Science.gov

Sample records for kromudledningen ved qaqortoq

  1. ABC and VED Analysis in Medical Stores Inventory Control.

    PubMed

    Gupta, R; Gupta, K K; Jain, B R; Garg, R K

    2007-10-01

    The basic principle of inventory control is ABC based on cost criteria and VED on criticality. Based on ABC-VED matrix, economic analysis of drug expenditure of priced vocabulary of medical stores (PVMS) section 01 for the year 2003 of a 190 bedded service hospital was under taken. Out of 493 drugs in PVMS section 01, only 325 drugs were being used in the reference hospital. The total cost of drugs used was Rupees 55,23,503. Of these 325 drugs, 47(14.4%) drugs were Category A, consuming 70% of total expenditure, 73 (22.46 %) drugs Category B consuming 20% and rest 205 drugs (63.7 %) Category C drugs cost only 10% of expenditure. VED categorization done by consensus opinion of medical officers, found 24 (7.3%) drugs vital, 160 (49.3%) essential and rest 141 (43.3 %) desirable. On coupling the two techniques ABC-VED matrix was made and drugs were classified in to Category I (AV+BV+CV+AE+AD) comprising 68 drugs, Category II (BE + CE +BD) 159 and Category III (CD) 98 drugs. The management of Category I drugs was monitored by top management resulting in better control on the annual expenses and at the same time making available the vital Category II by middle and Category III at lower mangerial level.

  2. Life and consciousness – The Vedāntic view

    PubMed Central

    Shanta, Bhakti Niskama

    2015-01-01

    In the past, philosophers, scientists, and even the general opinion, had no problem in accepting the existence of consciousness in the same way as the existence of the physical world. After the advent of Newtonian mechanics, science embraced a complete materialistic conception about reality. Scientists started proposing hypotheses like abiogenesis (origin of first life from accumulation of atoms and molecules) and the Big Bang theory (the explosion theory for explaining the origin of universe). How the universe came to be what it is now is a key philosophical question. The hypothesis that it came from Nothing (as proposed by Stephen Hawking, among others), proves to be dissembling, since the quantum vacuum can hardly be considered a void. In modern science, it is generally assumed that matter existed before the universe came to be. Modern science hypothesizes that the manifestation of life on Earth is nothing but a mere increment in the complexity of matter — and hence is an outcome of evolution of matter (chemical evolution) following the Big Bang. After the manifestation of life, modern science believed that chemical evolution transformed itself into biological evolution, which then had caused the entire biodiversity on our planet. The ontological view of the organism as a complex machine presumes life as just a chance occurrence, without any inner purpose. This approach in science leaves no room for the subjective aspect of consciousness in its attempt to know the world as the relationships among forces, atoms, and molecules. On the other hand, the Vedāntic view states that the origin of everything material and nonmaterial is sentient and absolute (unconditioned). Thus, sentient life is primitive and reproductive of itself – omne vivum ex vivo – life comes from life. This is the scientifically verified law of experience. Life is essentially cognitive and conscious. And, consciousness, which is fundamental, manifests itself in the gradational forms of all

  3. Life and consciousness - The Vedāntic view.

    PubMed

    Shanta, Bhakti Niskama

    2015-01-01

    In the past, philosophers, scientists, and even the general opinion, had no problem in accepting the existence of consciousness in the same way as the existence of the physical world. After the advent of Newtonian mechanics, science embraced a complete materialistic conception about reality. Scientists started proposing hypotheses like abiogenesis (origin of first life from accumulation of atoms and molecules) and the Big Bang theory (the explosion theory for explaining the origin of universe). How the universe came to be what it is now is a key philosophical question. The hypothesis that it came from Nothing (as proposed by Stephen Hawking, among others), proves to be dissembling, since the quantum vacuum can hardly be considered a void. In modern science, it is generally assumed that matter existed before the universe came to be. Modern science hypothesizes that the manifestation of life on Earth is nothing but a mere increment in the complexity of matter - and hence is an outcome of evolution of matter (chemical evolution) following the Big Bang. After the manifestation of life, modern science believed that chemical evolution transformed itself into biological evolution, which then had caused the entire biodiversity on our planet. The ontological view of the organism as a complex machine presumes life as just a chance occurrence, without any inner purpose. This approach in science leaves no room for the subjective aspect of consciousness in its attempt to know the world as the relationships among forces, atoms, and molecules. On the other hand, the Vedāntic view states that the origin of everything material and nonmaterial is sentient and absolute (unconditioned). Thus, sentient life is primitive and reproductive of itself - omne vivum ex vivo - life comes from life. This is the scientifically verified law of experience. Life is essentially cognitive and conscious. And, consciousness, which is fundamental, manifests itself in the gradational forms of all

  4. Performance of viscoelastic dampers (VED) under various temperatures and application of magnetorheological dampers (MRD) for seismic control of structures

    NASA Astrophysics Data System (ADS)

    Bhatti, Abdul Qadir

    2013-08-01

    A number of studies have been carried out to investigate the performance of viscoelastic dampers (VEDs) and magnetorheological dampers (MRDs) in controlling the seismic response of buildings, but very few of them regarding the effect of temperature on the behavior of those dampers. The energy absorption properties of the VEDs are dependent on the ambient temperature, excitation frequency and strain amplitude. Several mathematical models have been investigated for reproducing the experimental behavior of single degree of freedom VEDs and MEDs. Of these, only the fractional derivative model can reflect the influence of temperature which is, however, so complex that it is difficult to apply in structural analysis. In order to verify the effect of temperature, two case studies of structural element have been conducted: once using VED and once using MRD. Kelvin-Voigt mathematical model applied, they were investigated and after analyzing the results, the force vs. displacement showed that MRD achieved a high force capacity and a better performance than VED. Furthermore, the effect of the temperature in case of VED observed via plotting the dissipated energy hysteresis at different temperatures. These results validate the effect of the temperature as the lower the temperature the more viscous the dashpot element becomes, hence improving damping, but this is up to a specific low temperature.

  5. ABC and VED Analysis of the Pharmacy Store of a Tertiary Care Teaching, Research and Referral Healthcare Institute of India.

    PubMed

    Devnani, M; Gupta, Ak; Nigah, R

    2010-04-01

    The ABC and VED (vital, essential, desirable) analysis of the pharmacy store of Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, was conducted to identify the categories of items needing stringent management control. The annual consumption and expenditure incurred on each item of pharmacy for the year 2007-08 was analyzed and inventory control techniques, i.e. ABC, VED and ABC-VED matrix analysis, were applied. The drug formulary of the pharmacy consisted of 421 items. The total annual drug expenditure (ADE) on items issued in 2007-08 was Rs. 40,012,612. ABC analysis revealed 13.78%, 21.85% and 64.37% items as A, B and C category items, respectively, accounting for 69.97%, 19.95% and 10.08% of ADE of the pharmacy. VED analysis showed 12.11%, 59.38% and 28.51% items as V, E, and D category items, respectively, accounting for 17.14%, 72.38% and 10.48% of ADE of the pharmacy. On ABC-VED matrix analysis, 22.09%, 54.63% and 23.28% items were found to be category I, II and III items, respectively, accounting for 74.21%, 22.23% and 3.56% of ADE of the pharmacy. The ABC and VED techniques need to be adopted as a routine practice for optimal use of resources and elimination of out-of-stock situations in the hospital pharmacy.

  6. ABC and VED Analysis of the Pharmacy Store of a Tertiary Care Teaching, Research and Referral Healthcare Institute of India

    PubMed Central

    Devnani, M; Gupta, AK; Nigah, R

    2010-01-01

    The ABC and VED (vital, essential, desirable) analysis of the pharmacy store of Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, was conducted to identify the categories of items needing stringent management control. The annual consumption and expenditure incurred on each item of pharmacy for the year 2007-08 was analyzed and inventory control techniques, i.e. ABC, VED and ABC-VED matrix analysis, were applied. The drug formulary of the pharmacy consisted of 421 items. The total annual drug expenditure (ADE) on items issued in 2007-08 was Rs. 40,012,612. ABC analysis revealed 13.78%, 21.85% and 64.37% items as A, B and C category items, respectively, accounting for 69.97%, 19.95% and 10.08% of ADE of the pharmacy. VED analysis showed 12.11%, 59.38% and 28.51% items as V, E, and D category items, respectively, accounting for 17.14%, 72.38% and 10.48% of ADE of the pharmacy. On ABC-VED matrix analysis, 22.09%, 54.63% and 23.28% items were found to be category I, II and III items, respectively, accounting for 74.21%, 22.23% and 3.56% of ADE of the pharmacy. The ABC and VED techniques need to be adopted as a routine practice for optimal use of resources and elimination of out-of-stock situations in the hospital pharmacy. PMID:21264126

  7. Vedāntic view of life: Reply to Gustavo Caetano-Anollés

    PubMed Central

    2016-01-01

    ABSTRACT The author would like to thank Professor Gustavo Caetano-Anollés from Department of Crop Sciences, University of Illinois for his interest in his work. We may sometimes observe that there is a noticeable difference between the anecdote people narrate about the implications of a scientific paper and the real conclusion of the paper. Prof. Gustavo Caetano-Anollés's response1 is an ideal example of the same, where he has tried to make great hay about the implications of the article “Life and consciousness – The Vedāntic view.”2 The Vedāntic view subscribes neither to the views of ‘Creationist Movement’/‘Intelligent Design’, nor it supports some splendid anti-science proposal. Vedāntic view refutes the dominant reductionistic view of life in modern biology by proposing a viable alternative concept of ‘Organic Whole’ and thus serves a scientific critique to the nescience (avidyā) that is practiced on the name of science. PMID:27195069

  8. Vedāntic view of life: Reply to Gustavo Caetano-Anollés.

    PubMed

    Shanta, Bhakti Niskama

    2016-01-01

    The author would like to thank Professor Gustavo Caetano-Anollés from Department of Crop Sciences, University of Illinois for his interest in his work. We may sometimes observe that there is a noticeable difference between the anecdote people narrate about the implications of a scientific paper and the real conclusion of the paper. Prof. Gustavo Caetano-Anollés's response(1) is an ideal example of the same, where he has tried to make great hay about the implications of the article "Life and consciousness - The Vedāntic view."(2) The Vedāntic view subscribes neither to the views of 'Creationist Movement'/'Intelligent Design', nor it supports some splendid anti-science proposal. Vedāntic view refutes the dominant reductionistic view of life in modern biology by proposing a viable alternative concept of 'Organic Whole' and thus serves a scientific critique to the nescience (avidyā) that is practiced on the name of science.

  9. Terahertz-Regime, Micro-VEDs: Evaluation of Micromachined TWT Conceptual Designs

    NASA Technical Reports Server (NTRS)

    Booske, John H.; Kory, Carol L.; Gallagher, D.; van der Weide, Daniel W.; Limbach, S; Gustafson, P; Lee, W.-J.; Gallagher, S.; Jain, K.

    2001-01-01

    Summary form only given. The Terahertz (THz) region of the electromagnetic spectrum (approx.300-3000 GHz) has enormous potential for high-data-rate communications, spectroscopy, astronomy, space research, medicine, biology, surveillance, remote sensing, industrial process control, etc. The most critical roadblock to full exploitation of the THz band is lack of coherent radiation sources that are powerful (0.01-10.0 W continuous wave), efficient (>1 %), frequency agile (instantaneously tunable over 1% bandwidths or more), reliable, and relatively inexpensive. Micro-machined Vacuum Electron Devices (micro-VEDs) represent a promising solution. We describe prospects for miniature, THz-regime TWTs fabricated using micromachining techniques. Several approx.600 GHz conceptual designs are compared. Their expected performance has been analyzed using SD, 2.51), and 3D TWT codes. A folded waveguide (FWG) TWT forward-wave amplifier design is presented based on a Northrop Grumman (NGC) optimized design procedure. This conceptual device is compared to the simulated performance of a novel, micro-VED helix TWT. Conceptual FWG TWT backward-wave amplifiers and oscillators are also discussed. A scaled (100 GHz) FWG TWT operating at a relatively low voltage (-12 kV) is under development at NGC. Also, actual-size micromachining experiments are planned to evaluate the feasibility of arrays of micro-VED TWTs. Progress and results of these efforts are described. This work was supported, in part by AFOSR, ONR, and NSF.

  10. ABC-VED analysis of expendable medical stores at a tertiary care hospital.

    PubMed

    Kumar, Sushil; Chakravarty, A

    2015-01-01

    The modern system of medicine has evolved into a complex, sophisticated and expensive treatment modality in terms of cost of medicines and consumables. In any hospital, approximately 33% of total annual budget is spent on buying materials and supplies including medicines. ABC (Always, Better Control)-VED (Vital, Essential, Desirable) analysis of medical stores of a large teaching, tertiary care hospital of the Armed Forces was carried out to identify the categories of drugs needing focused managerial control. Annual consumption and expenditure data of expendable medical stores for one year was extracted from the drug expense book, followed by classification on its annual usage value. Subsequently, the factor of criticality was applied to arrive at a decision matrix for understanding the need for selective managerial control. The study revealed that out of 1536 items considered for the study, 6.77% (104), 19.27% (296) and 73.95% (1136) items were found to be A, B and C category items respectively. VED analysis revealed that vital items (V) accounted for 13.14% (201), essential items (E) for 56.37% (866) and desirable accounted for 30.49% items (469). ABC-VED matrix analysis of the inventory reveals that only 322 (21%) items out of an inventory of 1536 drugs belonging to category I will require maximum attention. Scientific inventory management tools need to be applied routinely for efficient management of medical stores, as it contributes to judicious use of limited resources and resultant improvement in patient care.

  11. Terahertz-Regime, Micro-VEDs: Evaluation of Micromachined TWT Conceptual Designs

    NASA Technical Reports Server (NTRS)

    Booske, John H.; Kory, Carol L.; Gallagher, D.; van der Weide, Daniel W.; Limbach, S; Gustafson, P; Lee, W.-J.; Gallagher, S.; Jain, K.

    2001-01-01

    Summary form only given. The Terahertz (THz) region of the electromagnetic spectrum (approx.300-3000 GHz) has enormous potential for high-data-rate communications, spectroscopy, astronomy, space research, medicine, biology, surveillance, remote sensing, industrial process control, etc. The most critical roadblock to full exploitation of the THz band is lack of coherent radiation sources that are powerful (0.01-10.0 W continuous wave), efficient (>1 %), frequency agile (instantaneously tunable over 1% bandwidths or more), reliable, and relatively inexpensive. Micro-machined Vacuum Electron Devices (micro-VEDs) represent a promising solution. We describe prospects for miniature, THz-regime TWTs fabricated using micromachining techniques. Several approx.600 GHz conceptual designs are compared. Their expected performance has been analyzed using SD, 2.51), and 3D TWT codes. A folded waveguide (FWG) TWT forward-wave amplifier design is presented based on a Northrop Grumman (NGC) optimized design procedure. This conceptual device is compared to the simulated performance of a novel, micro-VED helix TWT. Conceptual FWG TWT backward-wave amplifiers and oscillators are also discussed. A scaled (100 GHz) FWG TWT operating at a relatively low voltage (-12 kV) is under development at NGC. Also, actual-size micromachining experiments are planned to evaluate the feasibility of arrays of micro-VED TWTs. Progress and results of these efforts are described. This work was supported, in part by AFOSR, ONR, and NSF.

  12. Consciousness, cognition and the cognitive apparatus in the vedānta tradition.

    PubMed

    Balasubramanian, R

    2011-01-01

    A human being is a complex entity consisting of the Self (also known as Consciousness), mind, senses and the body. The Vedānta tradition holds that the mind, the senses and the body are essentially different from the Self or Consciousness. It is through consciousness that we are able to know the things of the world, making use of the medium of the mind and the senses. Furthermore, the mind, though material, is able to reveal things, borrowing the light from consciousness. From the phenomenological point of view, we have to answer the following questions: how does one know the mind/the mental operations/the cogitations of the mind? Does the mind know itself? Is it possible? There is, again, the problem of the intentionality of consciousness. Is consciousness intentional? According to Vedānta, consciousness by its very nature is not intentional, but it becomes intentional through the mind. The mind or the ego is not part of the consciousness; on the contrary, it is transcendent to consciousness. It is difficult to spell out the relation between consciousness and the mind. How does consciousness, which is totally different from the mind, get related to the mind in such a way that it makes the latter capable of comprehending the things of the world? The Vedānta tradition provides the answer to this question in terms of the knower-known relation. Consciousness is pure light, self-luminous by its very nature, that is, although it reveals other objects, it is not revealed by anything else. When Sartre describes it as nothingness, bereft of even ego, it is to show that it is pure light revealing objects outside it.

  13. Consciousness, Cognition and the Cognitive Apparatus in the Vedānta Tradition

    PubMed Central

    Balasubramanian, R.

    2011-01-01

    A human being is a complex entity consisting of the Self (also known as Consciousness), mind, senses and the body. The Vedānta tradition holds that the mind, the senses and the body are essentially different from the Self or Consciousness. It is through consciousness that we are able to know the things of the world, making use of the medium of the mind and the senses. Furthermore, the mind, though material, is able to reveal things, borrowing the light from consciousness. From the phenomenological point of view, we have to answer the following questions: how does one know the mind/the mental operations/the cogitations of the mind? Does the mind know itself? Is it possible? There is, again, the problem of the intentionality of consciousness. Is consciousness intentional? According to Vedānta, consciousness by its very nature is not intentional, but it becomes intentional through the mind. The mind or the ego is not part of the consciousness; on the contrary, it is transcendent to consciousness. It is difficult to spell out the relation between consciousness and the mind. How does consciousness, which is totally different from the mind, get related to the mind in such a way that it makes the latter capable of comprehending the things of the world? The Vedānta tradition provides the answer to this question in terms of the knower-known relation. Consciousness is pure light, self-luminous by its very nature, that is, although it reveals other objects, it is not revealed by anything else. When Sartre describes it as nothingness, bereft of even ego, it is to show that it is pure light revealing objects outside it. PMID:21694962

  14. ABC–VED analysis of expendable medical stores at a tertiary care hospital

    PubMed Central

    Kumar, Sushil; Chakravarty, A.

    2014-01-01

    Background The modern system of medicine has evolved into a complex, sophisticated and expensive treatment modality in terms of cost of medicines and consumables. In any hospital, approximately 33% of total annual budget is spent on buying materials and supplies including medicines. ABC (Always, Better Control)–VED (Vital, Essential, Desirable) analysis of medical stores of a large teaching, tertiary care hospital of the Armed Forces was carried out to identify the categories of drugs needing focused managerial control. Methods Annual consumption and expenditure data of expendable medical stores for one year was extracted from the drug expense book, followed by classification on its annual usage value. Subsequently, the factor of criticality was applied to arrive at a decision matrix for understanding the need for selective managerial control. Results The study revealed that out of 1536 items considered for the study, 6.77% (104), 19.27% (296) and 73.95% (1136) items were found to be A, B and C category items respectively. VED analysis revealed that vital items (V) accounted for 13.14% (201), essential items (E) for 56.37% (866) and desirable accounted for 30.49% items (469). ABC–VED matrix analysis of the inventory reveals that only 322 (21%) items out of an inventory of 1536 drugs belonging to category I will require maximum attention. Conclusion Scientific inventory management tools need to be applied routinely for efficient management of medical stores, as it contributes to judicious use of limited resources and resultant improvement in patient care. PMID:25609859

  15. Grasping at ontological straws: overcoming reductionism in the Advaita Vedānta-Neuroscience dialogue.

    PubMed

    Kaplan, Stephen

    2009-01-01

    Contemporary neuropsychology reveals that the parietal lobe contains neurons that are specifically attuned to the act of grasping and this act may be fundamental to the establishment of the phenomenal boundaries between subject and object. Furthermore, alterations to this process, such as the hypoactivation of this region during meditation or the hyperactivation associated with schizophrenia, may eliminate or confuse, respectively, the phenomenal boundaries between subject and object. Traversing disciplines, the Advaita Vedānta school of Hinduism traces some of its key terms for subject and object to the verbal root grah, to grasp. The subject is literally the grasper. Furthermore, the practice of asparśa yoga, the yoga of no-touch, is aimed at stopping, hypoactivating, the grasping process in order to transcend all subject-object boundaries. This paper will argue that while we have not uncovered an identity of thought, we have uncovered a confluence of ideas between these two disciplines. We will see that this confluence of ideas has not pitted the believer against the critic-not forced us into the great reductionism debate that has dominated so much of the interchange between religious studies and the sciences. This case study will illuminate some of the methodological ways around this reductionism battle and also the boundaries of both disciplines for the intellectual benefit of each.

  16. Training healthcare personnel for mass-casualty incidents in a virtual emergency department: VED II.

    PubMed

    Heinrichs, Wm Leroy; Youngblood, Patricia; Harter, Phillip; Kusumoto, Laura; Dev, Parvati

    2010-01-01

    Training emergency personnel on the clinical management of a mass-casualty incident (MCI) with prior chemical, biological, radioactive, nuclear, or explosives (CBRNE) -exposed patients is a component of hospital preparedness procedures. The objective of this research was to determine whether a Virtual Emergency Department (VED), designed after the Stanford University Medical Center's Emergency Department (ED) and populated with 10 virtual patient victims who suffered from a dirty bomb blast (radiological) and 10 who suffered from exposure to a nerve toxin (chemical), is an effective clinical environment for training ED physicians and nurses for such MCIs. Ten physicians with an average of four years of post-training experience, and 12 nurses with an average of 9.5 years of post-graduate experience at Stanford University Medical Center and San Mateo County Medical Center participated in this IRB-approved study. All individuals were provided electronic information about the clinical features of patients exposed to a nerve toxin or radioactive blast before the study date and an orientation to the "game" interface, including an opportunity to practice using it immediately prior to the study. An exit questionnaire was conducted using a Likert Scale test instrument. Among these 22 trainees, two-thirds of whom had prior Code Triage (multiple casualty incident) training, and one-half had prior CBRNE training, about two-thirds felt immersed in the virtual world much or all of the time. Prior to the training, only four trainees (18%) were confident about managing CBRNE MCIs. After the training, 19 (86%) felt either "confident" or "very confident", with 13 (59%) attributing this change to practicing in the virtual ED. Twenty-one (95%) of the trainees reported that the scenarios were useful for improving healthcare team skills training, the primary objective for creating them. Eighteen trainees (82%) believed that the cases also were instructive in learning about clinical

  17. Modelling Aṣṭādhyāyī: An Approach Based on the Methodology of Ancillary Disciplines (Vedāṅga)

    NASA Astrophysics Data System (ADS)

    Mishra, Anand

    This article proposes a general model based on the common methodological approach of the ancillary disciplines (Vedāṅga) associated with the Vedas taking examples from Śikṣā, Chandas, Vyākaraṇa and Prātiśā khya texts. It develops and elaborates this model further to represent the contents and processes of Aṣṭādhyāyī. Certain key features are added to my earlier modelling of Pāṇinian system of Sanskrit grammar. This includes broader coverage of the Pāṇinian meta-language, mechanism for automatic application of rules and positioning the grammatical system within the procedural complexes of ancillary disciplines.

  18. JPRS Report, West Europe

    DTIC Science & Technology

    1987-06-24

    They are Qaqortoq mayor Henrik Lund and Anders Brons of Egede & Brons. They will be Iceland’s consuls general in Greenland. The appointment of the...Minister Backs Policy, by Lars Henrik Bjorgum 92 TURKEY Overview of Need for Agricultural Reform (MILLIYET, 12 Mar 87) 94 THY New Delhi Line...development in women’s voting conduct, First Lieutenant and political scientist Carl- Henrik Hall pointed out in the latest issue of MILITAERT TIDSSKRIFT

  19. [Diabetes and alternative medicine: diabetic patients experiences with Ayur-Ved, "clinical ecology" and "cellular nutrition" methods].

    PubMed

    Vanelli, M; Chiari, G; Gugliotta, M; Capuano, C; Giacalone, T; Gruppi, L; Condò, M

    2002-04-01

    In the last two years we discovered that three of our patients with type 1 diabetes mellitus (0.8%) suffered an unexpected worsening in their glycemic control due to a reduction of their insulin dosage in favour of some "alternative" diabetes treatments using herbs, vitamins, fantastic diets and trace elements prescribed by non-medical practitioners. The first patient, a 6.6 year old boy, was admitted to hospital because of a severe ketoacidosis with first degree coma as a result of his parents having reduced his insulin dosage by 77% and replacing the insulin with an ayurvedic herbal preparation (Bardana Actium Lapp). The second patient, a 10.4 year old boy, was admitted to hospital after his teachers noticed that he appeared tired, thinner and polyuric. During hospital admission for mild ketoacidosis the mother, reluctant at first, finally confessed that her son was under the care of a "clinical ecologist". Having identified several food allergies this "clinical ecologist" had placed the child on a spartan diet of bread, water and salt, and had reduced his insulin dosage by 68%. The third patient, a 21 year old male, upon transfer to the Adult Diabetic Center, reported that he had been under the care of a pranotherapist for several years. The pranotherapist had prescribed a cellular nutrition preparation (called "Madonna drops"), a meditation program and also a 50% reduction in his insulin dosage. During this period his HbAlc values had increased from 6.4% to 12%. Current orthodox diabetes treatments are considered unsatisfactory by many people and it is thus not surprising that they search for "miracle" cures. It is important, however, that hospital staff do not ridicule the patients or their parents for trying these alternative therapies. Nevertheless, it would be useful for staff to discuss in advance these "therapies" with patients, highlighting their ineffectiveness and strongly discouraging cures that call for a reduction or elimination of the insulin treatment.

  20. ABC-VED Analysis of a Drug Store in the Department of Community Medicine of a Medical College in Delhi

    PubMed Central

    Anand, T.; Ingle, G. K.; Kishore, J.; Kumar, R

    2013-01-01

    A matrix based on coupling of cost (always, better and control) analysis and criticality (vital, essential and desirable) analysis was employed for drug inventory containing 129 items of drug store in the Department of Community Medicine of a Medical College in Delhi. The annual drug expenditure incurred on 129 drug items for the year 2010-2011 was found to be Rs. 4,35,847.85. On always, better and control analysis, 18.6, 24.0 and 57.4% drugs were found to be always, better and control category items, respectively, amounting for 69.1, 20.8 and 10.1% of annual drug expenditure. About 13.2 (17), 38.8 (50) and 48.0% (62) items were found to be vital, essential and desirable category items, respectively, amounting for 18.7, 49.5 and 31.8% of annual drug expenditure. Based on always, better and control-vital, essential and desirable matrix analysis there were 37 (28.68%) items in category I, 53 (41.09%) items in category II and 39 (30.23%) items in category III, amounting for 73.0, 22.2 and 4.8% of annual drug expenditure, respectively. To conclude, scientific inventory management tools are needed to be applied in routine for efficient management of the pharmacy stores as it contributes to not only in improvement in patient care but also judicious use of resources as well. PMID:23901172

  1. Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence.

    PubMed

    Lin, Hao-Cheng; Yang, Wen-Li; Zhang, Jun-Lan; Dai, Yu-Tian; Wang, Run

    2013-05-01

    Our previous study showed that vacuum erectile device (VED) therapy has improved erectile function in rats with bilateral cavernous nerve crush (BCNC) injuries. This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation (SO2) and to examine the effect of VED therapy on preventing penile shrinkage after BCNC. Thirty adult Sprague-Dawley rats were randomly assigned into three groups: group 1, sham surgery; group 2, BCNC; and group 3, BCNC+VED. Penile length and diameter were measured on a weekly basis. After 4 weeks of therapy, the penile blood was extracted by three methods for blood gas analysis (BGA): method 1, cavernous blood was aspirated at the flaccid state; method 2, cavernous blood was aspirated at the traction state; and method 3, cavernous blood was aspirated immediately after applying VED. SO2 values were tested by the blood gas analyzer. The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC (Penile shortening: BCNC group 1.9±1.1 mm; VED group 0.3±1.0 mm; P<0.01. Penile diameter reduction: BCNC group 0.28±0.14 mm; VED group 0.04±0.14 mm; P<0.01). The mean SO2±s.d. values were increased by VED application (88.25%±4.94%) compared to the flaccid (76.53%±4.16%) or traction groups (78.93%±2.56%) (P<0.05). The calculated blood constructs in the corpus cavernosum right after VED application were 62% arterial and 38% venous blood. These findings suggest that VED therapy can effectively preserve penile size in rats with BCNC injury. The beneficial effect of VED therapy is related to antihypoxia by increasing cavernous blood SO2.

  2. Vacuum erection devices revisited: its emerging role in the treatment of erectile dysfunction and early penile rehabilitation following prostate cancer therapy.

    PubMed

    Pahlajani, Geetu; Raina, Rupesh; Jones, Stephen; Ali, Marwan; Zippe, Craig

    2012-04-01

    Vacuum erection devices (VEDs) are becoming first-line therapies for the treatment of erectile dysfunction and preservation (rehabilitation) of erectile function following treatment for prostate cancer. Currently, there is limited efficacy of the use of phosphodiesterase type 5 inhibitors in elderly patients, or patients with moderate to severe diabetes, hypertension, and coronary artery disease. The article aims to study the role of VED in patients following prostate cancer therapy. Alternative therapies such as VED have emerged as one of the primary options for patients refractory to oral therapy. VED has also been successfully used in combination treatment with oral therapy and penile injections. More recently, there has been interest in the use of VED in early intervention protocols to encourage corporeal rehabilitation and prevention of postradical prostatectomy veno-occlusive dysfunction. This is evident by the preservation of penile length and girth that is seen with early use of the VED following radical prostatectomy. There are ongoing studies to help preserve penile length and girth with early use of VED following prostate brachytherapy and external beam radiation for prostate cancer. Recently, there has also been interest in the use of VED to help maintain penile length following surgical correction of Peyronie's disease and to increase penile size prior to implantation of the penile prosthesis. VEDs can be one of the options for penile rehabilitation after prostate cancer therapy. © 2010 International Society for Sexual Medicine.

  3. Vacuum therapy in penile rehabilitation after radical prostatectomy: review of hemodynamic and antihypoxic evidence

    PubMed Central

    Qian, Sheng-Qiang; Gao, Liang; Wei, Qiang; Yuan, Jiuhong

    2016-01-01

    Generally, hypoxia is a normal physiological condition in the flaccid penis, which is interrupted by regular nocturnal erections in men with normal erectile function.1 Lack of spontaneous and nocturnal erections after radical prostatectomy due to neuropraxia results in persistent hypoxia of cavernosal tissue, which leads to apoptosis and degeneration of cavernosal smooth muscle fibers. Therefore, overcoming hypoxia is believed to play a crucial role during neuropraxia. The use of a vacuum erectile device (VED) in penile rehabilitation is reportedly effective and may prevent loss of penile length. The corporal blood after VED use is increased and consists of both arterial and venous blood, as revealed by color Doppler sonography and blood gas analysis. A similar phenomenon was observed in negative pressure wound therapy (NPWT). However, NPWT employs a lower negative pressure than VED, and a hypoperfused zone, which increases in response to negative pressure adjacent to the wound edge, was observed. Nonetheless, questions regarding ideal subatmospheric pressure levels, modes of action, and therapeutic duration of VED remain unanswered. Moreover, it remains unclear whether a hypoperfused zone or PO2 gradient appears in the penis during VED therapy. To optimize a clinical VED protocol in penile rehabilitation, further research on the mechanism of VED, especially real-time PO2 measurements in different parts of the penis, should be performed. PMID:26289397

  4. Vacuum erection devices to treat erectile dysfunction and early penile rehabilitation following radical prostatectomy.

    PubMed

    Zippe, Craig D; Pahlajani, Geetu

    2008-11-01

    Vacuum erection devices (VED) are becoming first-line therapies for erectile dysfunction and preservation (rehabilitation) of erectile function following treatment for prostate cancer. Currently, phosphodiesterase-5 inhibitors have limited efficacy in elderly patients or patients with moderate to severe diabetes, hypertension, and coronary artery disease. Alternative therapies, such as VED, have emerged as a primary option for patients refractory to oral therapy. VED has also been successfully used in combination treatment with oral therapy and penile injections. More recently, there has been interest in the use of VED in early intervention protocols to encourage corporeal rehabilitation and prevention of post-radical prostatectomy venoocclusive dysfunction. This is evident by the preservation of penile length and girth seen with the early use of the VED following radical prostatectomy. There are ongoing studies to help preserve penile length and girth with early use of VED following prostate brachytherapy and external beam radiation for prostate cancer. Recently, there has also been interest in VED to help maintain penile length following surgical correction of Peyronie's disease and to increase penile size before implantation of the penile prosthesis.

  5. Vacuum therapy in penile rehabilitation after radical prostatectomy: review of hemodynamic and antihypoxic evidence.

    PubMed

    Qian, Sheng-Qiang; Gao, Liang; Wei, Qiang; Yuan, Jiuhong

    2016-01-01

    Generally, hypoxia is a normal physiological condition in the flaccid penis, which is interrupted by regular nocturnal erections in men with normal erectile function. [1] Lack of spontaneous and nocturnal erections after radical prostatectomy due to neuropraxia results in persistent hypoxia of cavernosal tissue, which leads to apoptosis and degeneration of cavernosal smooth muscle fibers. Therefore, overcoming hypoxia is believed to play a crucial role during neuropraxia. The use of a vacuum erectile device (VED) in penile rehabilitation is reportedly effective and may prevent loss of penile length. The corporal blood after VED use is increased and consists of both arterial and venous blood, as revealed by color Doppler sonography and blood gas analysis. A similar phenomenon was observed in negative pressure wound therapy (NPWT). However, NPWT employs a lower negative pressure than VED, and a hypoperfused zone, which increases in response to negative pressure adjacent to the wound edge, was observed. Nonetheless, questions regarding ideal subatmospheric pressure levels, modes of action, and therapeutic duration of VED remain unanswered. Moreover, it remains unclear whether a hypoperfused zone or PO 2 gradient appears in the penis during VED therapy. To optimize a clinical VED protocol in penile rehabilitation, further research on the mechanism of VED, especially real-time PO 2 measurements in different parts of the penis, should be performed.

  6. Molecular mechanisms of vacuum therapy in penile rehabilitation: a novel animal study.

    PubMed

    Yuan, Jiuhong; Lin, Haochen; Li, Ping; Zhang, Rongzheng; Luo, Annie; Berardinelli, Francesco; Dai, Yutian; Wang, Run

    2010-11-01

    Penile rehabilitation (PR) is widely applied after radical prostatectomy. Vacuum erectile device (VED) therapy is the one of three PR methods used in the clinical setting that improve erectile function (EF) and is the only PR method which may preserve penile length. However, its unknown mechanism hampered doctors' recommendations and patients' compliance. To assess the effects of VED therapy on erectile dysfunction (ED) in a rat model of bilateral cavernous nerve crush (BCNC) and to investigate the molecular mechanism of VED in postprostatectomy ED. This was an experimental study using Sprague-Dawley rats in three groups: sham, BCNC, and BCNC plus VED. Intervention included BCNC, electrical stimulation of the cavernous nerve (CNS), and VED therapy. At the end of a 4-wk period, CNS was used to assess EF by maximum intracavernosal pressure (ICP)/mean arterial pressure (MAP) ratio and duration (area under the curve [AUC]). For the structural analyses, whole rat penis was harvested. Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling assay was used for the assessment of apoptotic indices (AI). Immunohistochemistry was performed for endothelial nitric oxide synthase (eNOS), α-smooth muscle actin (ASMA), transforming growth factor beta 1 (TGF-β1), and hypoxia inducible factor-1α (HIF-1α). Staining for Masson's trichrome was utilized to calculate the smooth muscle/collagen ratios. EF was improved with VED therapy measured by ICP/MAP ratios and AUC. VED therapy reduced HIF-1α expression and AI significantly compared with control. Animals exposed to VED therapy had decreased TGF-β1 expression, increased smooth muscle/collagen ratios, and preserved ASMA and eNOS expression. To our knowledge, this is the first scientific study to suggest that VED therapy in the BCNC rat model preserves EF through antihypoxic, antiapoptotic, and antifibrotic mechanisms. Published by Elsevier B.V.

  7. Spontaneous Splenic Rupture in Vascular Ehlers-Danlos Syndrome.

    PubMed

    Batagini, Nayara Cioffi; Gornik, Heather; Kirksey, Lee

    2015-01-01

    Vascular Ehlers-Danlos Syndrome (VEDS) is a rare autosomal dominant collagen vascular disorder. Different from other Ehler-Danlos Syndrome subtypes, VEDS has poor prognosis due to severe fragility of connective tissues and association with life-threatening vascular and gastrointestinal complications. Spontaneous splenic rupture is a rare but hazardous complication related to this syndrome. To date, only 2 cases have been reported in the literature. Here we present another case of this uncommon complication, occurring in a 54-year-old woman in clinical follow-up for VEDS who presented with sudden onset of abdominal pain and hypotension.

  8. Recurrent arterial aneurysm rupture of the upper extremity in a patient with vascular-type Ehlers-Danlos syndrome.

    PubMed

    Nakanishi, Koji; Tajiri, Nobuhisa; Nakai, Mikizo; Shimizu, Shuji

    2014-10-01

    Arterial aneurysm rupture is one of the most critical complications in patients with vascular-type Ehlers-Danlos syndrome (vEDS). Here, we report a case of recurrent aneurysm rupture successfully treated by endovascular embolization. A 38-year old woman who underwent brachial artery ligation for a ruptured aneurysm was diagnosed postoperatively with vEDS. Impending rupture of a collateral artery aneurysm was encountered 5 months after the initial open surgery. Endovascular embolization with a liquid embolic agent was successfully performed. Given that arterial rupture can occur repeatedly in patients with vEDS, careful life-long follow-up is necessary.

  9. Oral phenotype and scoring of vascular Ehlers–Danlos syndrome: a case–control study

    PubMed Central

    Frank, Michael; Gogly, Bruno; Golmard, Lisa; Naveau, Adrien; Chérifi, Hafida; Emmerich, Joseph; Gaultier, Frédérick; Berdal, Ariane; Jeunemaitre, Xavier; Fournier, Benjamin P J

    2012-01-01

    Objective Vascular Ehlers–Danlos syndrome (vEDS) is a rare genetic condition related to mutations in the COL3A1 gene, responsible of vascular, digestive and uterine accidents. Difficulty of clinical diagnosis has led to the design of diagnostic criteria, summarised in the Villefranche classification. The goal was to assess oral features of vEDS. Gingival recession is the only oral sign recognised as a minor diagnostic criterion. The authors aimed to check this assumption since bibliographical search related to gingival recession in vEDS proved scarce. Design Prospective case–control study. Setting Dental surgery department in a French tertiary hospital. Participants 17 consecutive patients with genetically proven vEDS, aged 19–55 years, were compared with 46 age- and sex-matched controls. Observations Complete oral examination (clinical and radiological) with standardised assessment of periodontal structure, temporomandibular joint function and dental characteristics were performed. COL3A1 mutations were identified by direct sequencing of genomic or complementary DNA. Results Prevalence of gingival recession was low among patients with vEDS, as for periodontitis. Conversely, patients showed marked gingival fragility, temporomandibular disorders, dentin formation defects, molar root fusion and increased root length. After logistic regression, three variables remained significantly associated to vEDS. These variables were integrated in a diagnostic oral score with 87.5% and 97% sensitivity and specificity, respectively. Conclusions Gingival recession is an inappropriate diagnostic criterion for vEDS. Several new specific oral signs of the disease were identified, whose combination may be of greater value in diagnosing vEDS. PMID:22492385

  10. Effect of Penile Traction and Vacuum Erectile Device for Peyronie's Disease in an Animal Model.

    PubMed

    Lin, Haocheng; Liu, Chunhui; Wang, Run

    2017-09-08

    Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie's disease (PD). To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. Peyronie's plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups. In the VED group, vacuum pressure was applied to the cylinder to induce penile engorgement inside the cylinder for 1 minute. The penis was allowed to deflate completely for another 1 minute. This was repeated for five cycles (inflate and deflate). In the TD group, the rat penis was straightened by a suspended tension gauge at the same tension by clamping the prepuce. This was performed three times per day at 20 minutes per session, with 5-minute intervals between sessions. The entire treatment duration was 4 weeks. Penile curvature, intracavernosal pressure, and mean arterial pressure were measured. Immunohistochemistry for α-smooth muscle actin, transforming growth factor-β1 and mothers against decapentaplegic homolog 2/3 were performed. The TD and VED groups had less penile curvature compared with the control group (15.3 ± 5.3° for TD, 28.4 ± 6.8° for VED, 38.6 ± 10.5° for control; P < .001 for TD vs control, P < .05 for VED vs control). The TD group also had less penile curvature compared with the VED group (P < .05). The VED group had a higher ratio of intracavernosal pressure to mean arterial pressure compared with the two other groups (0.56 ± 0.10 for VED, 0.38 ± 0.06 for TD, 0.32 ± 0.07 for control; P < .001). The immunohistochemistry results showed the VED group had more preserved α-smooth muscle actin with less transforming growth factor-β1 and mothers against decapentaplegic homolog 2/3 than the TD and control groups in the corpus cavernosa. Various benefits can be observed with the TD and

  11. A pilot study to determine penile oxygen saturation before and after vacuum therapy in patients with erectile dysfunction after radical prostatectomy.

    PubMed

    Welliver, R Charles; Mechlin, Clay; Goodwin, Brianne; Alukal, Joseph P; McCullough, Andrew R

    2014-04-01

    Provoked and spontaneous nocturnal erections are thought to play a role in maintenance of male sexual health through oxygenation of the corpus cavernosa. Conversely, hypoxia is thought to be an etiological factor in the pathogenesis of cavernosal fibrosis and long-term erectile dysfunction. It has been hypothesized that the early penile hypoxia after radical prostatectomy (RP) may lead to fibrosis and consequently a decrease in stretched penile length and long-term erectile dysfunction. The aim of this study was to assess the changes in penile tissue oxygenation with vacuum erection device (VED) use. Twenty men between 2 and 24 months following RP were enrolled prospectively. Each man cycled a VED to achieve full erection 10 consecutive times over a period of approximately 2 minutes without constriction ring. Tissue oximetry was measured at baseline and immediately after VED using a tissue oximeter at five sites: right thigh, right corpora, glans, left corpora, and left thigh. Additional measurements were captured over the course of an hour. Mean age and time from surgery was 58.2 years and 12.6 months, respectively, and the average Sexual Health Inventory for Men score was 7. Use of the VED significantly increased both glanular and corporal oximetry relative to the baseline values for the entire 60 minutes. An initial increase of 55% was seen in corporal oxygenation with VED use. This is the first study demonstrating that a single, brief application of the VED without a constriction ring results in significant improvement in penile oxygen saturation. The use of a VED has significant benefits for patients both with regard to cost and invasiveness when compared with other penile rehabilitation protocols. © 2014 International Society for Sexual Medicine.

  12. [Brachial artery endothelial function in teenagers with obesity depending on severity of clinical, trophological and metabolic disorders].

    PubMed

    Maskova, G S; Chernaia, N L; Nagornova, E Iu; Fomina, O V; Byteva, T A

    2014-01-01

    We carried out complex examination of 68 adolescents aged 11-17 years with primary obesity which in addition to assessment of clinical-anamnestic, laboratory data and functional parameters of cardiovascular system included registration of reaction of brachial artery endothelium to reactive hyperemia. Vascular endothelial dysfunction (VED) was found in 66% of obese teenagers. Obesity in adolescents with VED was characterized by aggravated course with higher fat mass index (36.8 +/- 4.39%) and prevalence of hypothalamic (42%) and metabolic (8.8%) syndromes. Stable arterial hypertension (AH) found in 37% of examined adolescents was 1.5 times more often registered in those with VED. We distinguished 4 groups of adolescents with various degree of risk of development of cardiovascular disorders: with stable AH and VED (group I), with stable AH and normal function of vascular endothelium (group II), with normal or labile arterial pressure with VED (group III), with normal or labile arterial pressure with normal function of vascular endothelium. It is expedient to supplement examination of obese adolescents with assessment of the state of vascular endothelium aiming at determination of degree of risk of development of atherosclerosis and/or stable AH.

  13. Vessel enhancing diffusion: a scale space representation of vessel structures.

    PubMed

    Manniesing, Rashindra; Viergever, Max A; Niessen, Wiro J

    2006-12-01

    A method is proposed to enhance vascular structures within the framework of scale space theory. We combine a smooth vessel filter which is based on a geometrical analysis of the Hessian's eigensystem, with a non-linear anisotropic diffusion scheme. The amount and orientation of diffusion depend on the local vessel likeliness. Vessel enhancing diffusion (VED) is applied to patient and phantom data and compared to linear, regularized Perona-Malik, edge and coherence enhancing diffusion. The method performs better than most of the existing techniques in visualizing vessels with varying radii and in enhancing vessel appearance. A diameter study on phantom data shows that VED least affects the accuracy of diameter measurements. It is shown that using VED as a preprocessing step improves level set based segmentation of the cerebral vasculature, in particular segmentation of the smaller vessels of the vasculature.

  14. Spontaneous Dissection of the Renal Artery in Vascular Ehlers-Danlos Syndrome

    PubMed Central

    Pereira, Filipa; Cardoso, Teresa; Sá, Paula

    2015-01-01

    Ehlers-Danlos syndrome (EDS) is a rare heterogeneous group of connective tissue disorders. The vascular type (vEDS) is an autosomal dominant disorder caused by heterozygous mutations in the COL3A1 gene predisposing to premature arterial, intestinal, or uterine rupture. We report a case of a 38-year-old woman with a recent diagnosis of vEDS admitted in the Emergency Department with a suspicion of a pyelonephritis that evolved to a cardiopulmonary arrest. A fatal retroperitoneal hematoma related with a haemorrhagic dissection of the right renal artery was found after emergency surgery. This case highlights the need to be aware of the particular characteristics of vEDS, such as a severe vascular complication that can lead to a fatal outcome. PMID:26175915

  15. Total pleural covering technique for intractable pneumothorax in patient with Ehlers-Danlos syndrome.

    PubMed

    Kadota, Yoshihisa; Fukui, Eriko; Kitahara, Naoto; Okura, Eiji; Ohta, Mitsunori

    2016-07-01

    We report a patient with vascular-type Ehlers-Danlos syndrome (vEDS) who developed pneumothorax and was treated with a total pleural covering technique (TPC). A 24-year-old man developed repeat pneumothorax with intermittent hemo-sputum. Based on unusual radiological manifestations of lung lesions and physical findings, EDS was suspected as an underlying cause of the pneumothorax. Surgical treatment was performed using a mediastinal fat pad and TPC, and no relapse was seen up to 2 years after surgery. TPC is a less invasive surgical approach for selected patients with vEDS. Accurate underlying diagnosis of vEDS and systemic evaluation of vascular complications are necessary before planning surgery.

  16. [Penile rehabilitation with vacuum erection device for erectile dysfunction after radical prostatectomy].

    PubMed

    Shen, Yi-Jun; Ye, Ding-Wei; Yao, Xu-Dong; Zhang, Shi-Lin; Dai, Bo; Zhang, Hai-Liang; Zhu, Yao

    2012-08-01

    To investigate the efficacy and safety of vacuum erection device (VED) for erectile dysfunction (ED) after radical prostatectomy (RP). Six cases of ED after open RP were reviewed. Three of the patients started a daily rehabilitation protocol using VED 10 min/d within 3 months after RP (group A, early intervention), while the other 3 initiated the same protocol after 12 months (group B, late intervention). We compared the IIEF-5 scores as well as stretched penile lengths and mid-shaft circumferences before and after 3 and 6 months of VED rehabilitation. We also assessed the safety of the device and sexual satisfaction of the patients and their partners. The mean IIEF-5 score of the six cases was remarkably increased at 3 and 6 months of VED rehabilitation (P < 0.05), significantly higher in group A than in B at 3 months (8.7 +/- 0.6 vs 6.7 +/- 0.6, P < 0.05) and 6 months (13.0 +/- 1.0 vs 8.3 +/- 1.5, P < 0.05). After 6 months of VED rehabilitation, there were no significant changes in stretched penile length or mid-shaft circumference in group A, both significantly decreased in group B (P < 0.05), and sexual satisfaction of the patients and their partners were 83.3% and 50%, respectively. No serious adverse events were observed except mild complaint of pe- nile skin darkening in 1 case and numb feeling during the intercourse in 2. Early use of VED after RP improves erectile function and helps to preserve the length and mid-shaft circumference of the penis.

  17. Comparison of visual and computerized estrous detection and evaluation of influencing factors.

    PubMed

    Gaude, Ina; Kempf, Andreas; Strüve, Klaas Dietrich; Hoedemaker, Martina

    2017-09-01

    The aim of this study was to compare the automatic estrous detection system (AED) Heatime(®) with visual estrous detection (VED). The study was conducted on 139 Holstein Friesian cows in one dairy herd in Northern Germany. The cows were fitted with activity collars from d 21 postpartum until d 40 of gestation and a 30-min visual estrous observation was conducted three times a day. In addition, as a separate part of the VED, estrous detection by exclusive consideration of standing estrus (SE) was investigated. Ovulation detected by regular trans-rectal ultrasonography and serum progesterone analyses served as gold standard to calculate estrous detection rate (EDR) and reliability rate (RR) for each of the three estrous detection systems (AED, VED and SE). Change in body condition antepartum and postpartum, lameness, milk yield and milk fat- milk protein- ratio (FPR) on the expression and detection of estrus were investigated. Estrus was more precisely detected by the AED (EDR: 85.1%) than by VED (EDR: 52.2%) and SE (EDR: 22.3%) (P<0.05). The RR when using the three methods did not differ (P>0.05). Changes in body condition, lameness, milk yield or the FPR were not associated with the estrous detection rate by the AED. The estrous detection rate by VED in lame animals (EDR: 24.2%) was, however, less than in cows without any lameness (EDR: 52.7%; P<0.05). In conclusion, the AED Heatime(®) system can be effectively used for estrous detection and can be used to more precisely detect estrus than with VED. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Acute saline expansion increases nephron filtration and distal flow rate but maintains tubuloglomerular feedback responsiveness: role of adenosine A1 receptors

    PubMed Central

    Singh, Prabhleen; Deng, Aihua; Thomson, Scott C.; Vallon, Volker

    2012-01-01

    Temporal adaptation of tubuloglomerular feedback (TGF) permits readjustment of the relationship of nephron filtration rate [single nephron glomerular filtration rate (SNGFR)] and early distal tubular flow rate (VED) while maintaining TGF responsiveness. We used closed-loop assessment of TGF in hydropenia and after acute saline volume expansion (SE; 10% body wt over 1 h) to determine whether 1) temporal adaptation of TGF occurs, 2) adenosine A1 receptors (A1R) mediate TGF responsiveness, and 3) inhibition of TGF affects SNGFR, VED, or urinary excretion under these conditions. SNGFR was evaluated in Fromter-Wistar rats by micropuncture in 1) early distal tubules (ambient flow at macula densa), 2) recollected from early distal tubules while 12 nl/min isotonic fluid was added to late proximal tubule (increased flow to macula densa), and 3) from proximal tubules of same nephrons (zero flow to macula densa). SE increased both ambient SNGFR and VED compared with hydropenia, whereas TGF responsiveness (proximal-distal difference in SNGFR, distal SNGFR response to adding fluid to proximal tubule) was maintained, demonstrating TGF adaptation. A1R blockade completely inhibited TGF responsiveness during SE and made VED more susceptible to perturbation in proximal tubular flow, but did not alter ambient SNGFR or VED. Greater urinary excretion of fluid and Na+ with A1R blockade may reflect additional effects on the distal nephron in hydropenia and SE. In conclusion, A1R-independent mechanisms adjust SNGFR and VED to higher values after SE, which facilitates fluid and Na+ excretion. Concurrently, TGF adapts and stabilizes early distal delivery at the new setpoint in an A1R-dependent mechanism. PMID:22622464

  19. Inventory Analysis in a Private Dental Hospital in Bangalore, India.

    PubMed

    Gupta, Nitin; Krishnappa, Pushpanjali

    2016-11-01

    There are various approaches for inventory management. Of all the inventory control systems, ABC (Always, Better, Control) and VED (Vital, Essential, Desirable) matrix is most suitable for dental stores. We could not find any literature pertaining to inventory analysis in a private dental hospital. So, we conducted a study in a private dental hospital in Bangalore, Karnataka, India. The present study aimed at evolving an inventory control plan for a private dental institution by categorizing the materials utilizing an ABC-VED coupling matrix. The study analysed the annual consumption, the expenditure incurred for the dental consumables and developed a matrix based on ABC and VED analysis to narrow down the group of consumables for managerial monitoring. Of the 215 consumables used 13.5% (A category) consumed 70% of total annual expenditure. About 21% of the consumables (Category B) consumed 20% and 65.5% (C category) accounted for 10% of the annual expenditure. The VED analysis found 47% consumables as vital, 37.6% as essential and 15.4% as desirable category. ABC-VED matrix analysis categorized 51.6%, 33.5% and 14.8% of consumables as category I, II and III, respectively. Categorization by the ABC-VED coupling matrix model helps to narrow down on fewer consumables. The management of Category I consumables was monitored by top management resulting in better control on the annual expenses and at the same time making available the vital consumables. Category II was monitored by middle and Category III at lower managerial level.

  20. Inventory Analysis in a Private Dental Hospital in Bangalore, India

    PubMed Central

    Krishnappa, Pushpanjali

    2016-01-01

    Introduction There are various approaches for inventory management. Of all the inventory control systems, ABC (Always, Better, Control) and VED (Vital, Essential, Desirable) matrix is most suitable for dental stores. We could not find any literature pertaining to inventory analysis in a private dental hospital. So, we conducted a study in a private dental hospital in Bangalore, Karnataka, India. Aim The present study aimed at evolving an inventory control plan for a private dental institution by categorizing the materials utilizing an ABC-VED coupling matrix. Materials and Methods The study analysed the annual consumption, the expenditure incurred for the dental consumables and developed a matrix based on ABC and VED analysis to narrow down the group of consumables for managerial monitoring. Results Of the 215 consumables used 13.5% (A category) consumed 70% of total annual expenditure. About 21% of the consumables (Category B) consumed 20% and 65.5% (C category) accounted for 10% of the annual expenditure. The VED analysis found 47% consumables as vital, 37.6% as essential and 15.4% as desirable category. ABC-VED matrix analysis categorized 51.6%, 33.5% and 14.8% of consumables as category I, II and III, respectively. Conclusion Categorization by the ABC-VED coupling matrix model helps to narrow down on fewer consumables. The management of Category I consumables was monitored by top management resulting in better control on the annual expenses and at the same time making available the vital consumables. Category II was monitored by middle and Category III at lower managerial level. PMID:28050404

  1. Preservation of penile length after radical prostatectomy: early intervention with a vacuum erection device.

    PubMed

    Dalkin, B L; Christopher, B A

    2007-01-01

    Radical prostatectomy has been shown to have a potential negative impact on penile health. Stretched penile length (SPL), which most closely correlates with erect penile length, was significantly reduced in almost half of men undergoing surgery in several studies. The purpose of this study was to test whether early intervention after surgery with a vacuum erection device could prevent the changes in penile health, as defined by SPL, found in prior studies. Forty-two men with good preoperative sexual function undergoing nerve-sparing radical prostatectomy underwent measurement of SPL preoperative and at 3 months postoperative by a single investigator. Daily use of a vacuum erection device (VED) was begun the day after catheter removal, and continued for 90 days. Men kept a log of their compliance with daily VED use. A decrease in SPL of > or = 1.0 cm was considered significant. Out of 42 men, 39 completed the study. In men who used the VED >50% of possible days, only 1/36 (3%) had a decrease in SPL of > or = 1.0 cm. Of the three men with poor VED compliance, two (67%) had a reduction in SPL of > or = 1.0 cm. When compared to prior studies where 48% of men after surgery had a significant reduction in SPL, early intervention with the daily use of a VED resulted in a significantly lower risk of loss of penile length (P<0.0001). For men wishing to preserve penile health/length after surgery, early intervention with the daily use of a VED should be strongly recommended.

  2. Cervical artery dissections and type A aortic dissection in a family with a novel missense COL3A1 mutation of vascular type Ehlers-Danlos syndrome.

    PubMed

    Makrygiannis, Georgios; Loeys, Bart; Defraigne, Jean-Olivier; Sakalihasan, Natzi

    2015-11-01

    Cervical artery dissection (CeAD) is a rare condition. One of the causes is the vascular type of Ehlers-Danlos syndrome (vEDS). A novel missense mutation in COL3A1 was found in a young patient with CeAD as the single manifestation of vEDS. This is a heterozygous c.953G > A mutation in exon 14, disrupting the normal Gly-X-Y repeats of type III procollagen, by converting glycine to aspartic acid.

  3. Elastic and viscoelastic crustal deformations in Greenland due to ice mass changes

    NASA Astrophysics Data System (ADS)

    Khan, S. A.; Wahr, J.; Dam, T. V.; Larson, K. M.; Francis, O.; Leuliette, E. W.; Hamilton, G. S.; Stearns, L. A.

    2007-12-01

    We analyze data from ~10 continuous Global Positioning System (GPS) receivers and one tide gauge, all located along the edge of the Greenland ice sheet, to determine vertical uplift rates. We compare our results with predictions based on the ICE-5G deglaciation model of Peltier [2004]. Results from the GPS receiver at Kellyville and from the tide gauge at Nuuk, indicate that ICE-5G overestimates the subsidence rates at those locations by 1-2 mm/yr. Kellyville and Nuuk are located along the southwestern margin of the Greenland ice sheet, and the observed negative uplift rates are consistent with independent evidence that the ice margin along the southwestern edge readvanced during the last ~8 kyrs years to its current position. The ICE-5G glaciation- deglaciation history includes a readvance between the latitudes of 62 N and 72 N. The GPS measurements suggest the ICE-5G readvance may be too large. Our GPS results at Qaqortoq, located at the southern tip of Greenland, suggest a secular uplift rate of about -1 mm/yr, while ICE-5G predicts an uplift rate of 1 mm/yr. ICE-5G assumes no ice sheet readvance in south Greenland, including no readvance of the Qassimiut lobe (located at the southern tip of greenalnd) . The difference of 2 mm/yr can tentatively be explained as due to a ~60 km readvance of the Qassimiut lobe during the last ~3 kyrs. For the other GPS sites, the observed/predicted uplift rates are 3/-2 mm/yr at Kulusuk and indicate that ICE-5G does not exactly reproduce the correct rebound signal at those locations. The larger difference at Kulusuk, however, is probably due to the Earth's elastic response to ongoing changes in ice. The Kulusuk receiver is only ~90 km from the front of the Helheim glacier, where recent remote sensing observations have shown major periods of speedup between 2000 and 2005 [Howat et al., 2005] and thinning of the glacier by over 40 m from 2001 to 2003. We also analyze data from four continuous GPS receivers located between 0-150 km

  4. Sensitivity of the marine-terminating margins to Holocene climate change in south and southeast Greenland

    NASA Astrophysics Data System (ADS)

    Levy, L.; Larsen, N. K.; Kjaer, K. H.; Bjork, A. A.; Kjeldsen, K. K.; Funder, S.; Kelly, M. A.; Howley, J. A.

    2016-12-01

    The marine-terminating glaciers of the Greenland Ice Sheet (GrIS) are responding rapidly to present-day climate change. More than one-third of the GrIS's discharge flows to the ocean through the marine-terminating outlet glaciers of southeastern Greenland, making it a potentially important region of the ice sheet. Documenting how these outlet glaciers have responded to longer-term past climate change (i.e. the Holocene) allows for more accurate predictions of their response to future climate changes. Here, we present 36 new 10Be ages on boulders perched on bedrock and on bedrock that record the timing of ice marginal fluctuations in several fjords in southeast and south Greenland, a region where little is known about past ice fluctuations due to its relative inaccessibility. We show that at Skjoldungen Sund (63.4N), deglaciation was rapid, beginning by 10.1 ± 0.4 ka. Deglaciation occurred concurrently at Timmiarmiut Fjord (62.7N), 100 km to the south, at 10.3 ± 0.4 ka. We suggest that this was in response to the warming ocean and air temperatures of the early Holocene. Additionally, 10Be ages on boulders perched on bedrock just distal to the historic­ moraines in Timmiarmiut Fjord date to 1.7 ± 0.1 ka, indicating the presence of a late Holocene advance prior to the Little Ice Age. In southern Greenland, deglaciation at Lindenow Fjord (60.6N), which drains the Julienhåb ice cap, occurred at 11.2 ± 0.4 ka. The ice then retreated up-fjord at a rate of 70-100 m yr-1, comparable with modern retreat rates of 30-100 m yr-1. We hypothesize that the earlier deglaciation at Lindenow Fjord by 1 ka may indicate that the Julienhåb ice cap was more sensitive to early Holocene warming than the GrIS. Additional 10Be ages from Prins Christen Fjord and near Qaqortoq are forthcoming. These new 10Be ages provide a longer-term perspective of marine-terminating outlet glacier fluctuations in Greenland and show that the ice sheet responded sensitively to Holocene climate change.

  5. Simplified analysis of frame structures with viscoelastic dampers considering the effect of soil-structure interaction

    NASA Astrophysics Data System (ADS)

    Zhao, Xuefei; Wang, Shuguang; Du, Dongsheng; Liu, Weiqing

    2017-01-01

    In this study, simplified numerical models are developed to analyze the soil-structure interaction (SSI) effect on frame structures equipped with viscoelastic dampers (VEDs) based on pile group foundation. First, a single degree-of-freedom (SDOF) oscillator is successfully utilized to replace the SDOF energy dissipated structure considering the SSI effect. The equivalent period and damping ratio of the system are obtained through analogical analysis using the frequency transfer function with adoption of the modal strain energy (MSE) technique. A parametric analysis is carried out to study the SSI effect on the performance of VEDs. Then the equilibrium equations of the multi degree-of-freedom (MDOF) structure with VEDs considering SSI effect are established in the frequency domain. Based on the assumption that the superstructure of the coupled system possesses the classical normal mode, the MDOF superstructure is decoupled to a set of individual SDOF systems resting on a rigid foundation with adoption of the MSE technique through formula derivation. Numerical results demonstrate that the proposed methods have the advantage of reducing computational cost, however, retaining the satisfactory accuracy. The numerical method proposed herein can provide a fast evaluation of the efficiency of VEDs considering the SSI effect.

  6. Interdisciplinary evaluation of dysphagia: clinical swallowing evaluation and videoendoscopy of swallowing.

    PubMed

    Sordi, Marina de; Mourão, Lucia Figueiredo; Silva, Ariovaldo Armando da; Flosi, Luciana Claudia Leite

    2009-01-01

    Patients with dysphagia have impairments in many aspects, and an interdisciplinary approach is fundamental to define diagnosis and treatment. A joint approach in the clinical and videoendoscopy evaluation is paramount. To study the correlation between the clinical assessment (ACD) and the videoendoscopic (VED) assessment of swallowing by classifying the degree of severity and the qualitative/descriptive analyses of the procedures. cross-sectional, descriptive and comparative. held from March to December of 2006, at the Otolaryngology/Dysphagia ward of a hospital in the country side of São Paulo. 30 dysphagic patients with different disorders were assessed by ACD and VED. The data was classified by means of severity scales and qualitative/ descriptive analysis. the correlation between severity ACD and VED scales pointed to a statistically significant low agreement (KAPA = 0.4) (p=0,006). The correlation between the qualitative/descriptive analysis pointed to an excellent and statistically significant agreement (KAPA=0.962) (p<0.001) concerning the entire sample. the low agreement between the severity scales point to a need to perform both procedures, reinforcing VED as a doable procedure. The descriptive qualitative analysis pointed to an excellent agreement, and such data reinforces our need to understand swallowing as a process.

  7. Exploring the Meaningful Learning of Students in Second Life

    ERIC Educational Resources Information Center

    Keskitalo, Tuulikki; Pyykko, Elli; Ruokamo, Heli

    2011-01-01

    This study reports a case study in which a pedagogical model, namely the Global Virtual Education (GloVEd) model, which is based on the teaching-studying-learning process (TSL process) and the characteristics of meaningful learning, is developed and used to evaluate students' meaningful learning experiences during the Global Virtual Collaboration…

  8. Cloud/Mesoscale Model Development and Application Studies.

    DTIC Science & Technology

    1987-09-30

    rt t udy. Since ccmp,:etirFg his thesis thisJl task has recei4ved ~essempliasis, though our analysis of Derecho -type events associated with V’CCs... ambient wind. Parcel history can te observed spatially, varying as distance from the orographic barrier. With minimum unc-rtainty, we are thus able to

  9. A Rate-Dependent Viscoelastic Damage Model for Simulation of Solid Propellant Impacts

    NASA Astrophysics Data System (ADS)

    Matheson, Erik

    2005-07-01

    A viscoelastic deformation and damage model (VED) for solid rocket propellants has been developed based on an extensive set of mechanical properties experiments. Monotonic tensile tests performed at several strain rates showed rate and dilatation effects. During cyclic tensile tests, hysteresis and a rate-dependent shear modulus were observed. A tensile relaxation experiment showed significant stress decay in the sample. Taylor impact tests exhibited large dilatations without significant crack growth. Extensive modifications to a viscoelastic-viscoplastic model (VEP) necessary to capture these experimental results have led to development of the VED model. In particular, plasticity has been eliminated in the model, and the multiple Maxwell viscoelastic formulation has been replaced with a time-dependent shear modulus. Furthermore, the loading and unloading behaviors of the material are modeled independently. To characterize the damage and dilatation behavior, the Tensile Damage and Distention (TDD) model is run in conjunction with VED. The VED model is connected to a single-cell driver as well as to the CTH shock physics code. Simulations of tests show good comparisons with tensile tests and some aspects of the Taylor tests.

  10. A Rate-Dependent Viscoelastic Damage Model for Simulation of Solid Propellant Impacts

    NASA Astrophysics Data System (ADS)

    Matheson, E. R.; Nguyen, D. Q.

    2006-07-01

    A viscoelastic deformation and damage model (VED) for solid rocket propellants has been developed based on an extensive set of mechanical properties experiments. Monotonic tensile tests performed at several strain rates showed rate and dilatation effects. During cyclic tensile tests, hysteresis and a rate-dependent shear modulus were observed. A tensile relaxation experiment showed significant stress decay in the sample. Taylor impact tests exhibited large dilatations without significant crack growth. Extensive modifications to a viscoelastic-viscoplastic model (VEP) necessary to capture these experimental results have led to development of the VED model. In particular, plasticity has been eliminated in the model, and the multiple Maxwell viscoelastic formulation has been replaced with a time-dependent shear modulus. Furthermore, the loading and unloading behaviors of the material are modeled independently. To characterize the damage and dilatation behavior, the Tensile Damage and Distention (TDD) model is run in conjunction with VED. The VED model is connected to a single-cell driver as well as to the CTH shock physics code. Simulations of tests show good comparisons with tensile tests and some aspects of the Taylor tests.

  11. East Coast Air Combat Maneuvering Range (EC/ACMR) Ocean Tower Construction Completion Report.

    DTIC Science & Technology

    1978-03-01

    fahr ~cat ioni yard to the Vast -oat intallation sites was accomplished in two phases. The first phase invol!ved t ransportat ion of the derrick ha...meeting H. MEDICAl, No injuries, no serious disease . I. MORALE - Vcry Food 2. LT, MAYER, ROICC ACMR, SENDS. F. "- F-9

  12. JPRS Report, West Europe, Reference Aid, Glossary of Acronyms and Abbreviations of Norway

    DTIC Science & Technology

    1989-04-04

    alminnelig aim. mob. alminnelig mobilisering common, general, universal general mobilization ALP Anders Langes Parti (Norwegian party that favored...Univers itetet Home Guard Section at the University HVU Heimevernsavdeling ved Universitetet og hoyskolene i Oslo Home Guard Section at the... University and High Schools in Oslo hyg hygienisk sanitary; medical HYSB Haerens yrkesskole for bilteknisk befal Army Automobile Mechanics School

  13. Stressors and Coping in the Norwegian Aeromedical Detachment in Afghanistan 2008-2010

    DTIC Science & Technology

    2011-04-01

    Lärarhögskolan Stockholm. HLS Förlag. [4] Bache, M., & Hommelgaard, B. (1994). Danske FN- soldater – opplevelser og stressreaktioner. Unpublished report...College. [65] Widing, H., Davøen, L.M., Laberg, J.C., Johnsen, B.H., Brun,W. & Eid, J. (2002). Soldaters vurdering av egne militære ferdigheter ved

  14. MICRO-VERS. Micro-computer Software for the Vocational Education Reporting System. Version 3.1. Radio Shack TRS-80 Model III.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This manual is intended to accompany a software system for the TRS-80 Model III computer that is designed to aid local districts in completing vocational education enrollment claims and Vocational Education Data System (VEDS) reports. Part I, Introduction, gives a brief overview of the Microcomputer Vocational Education Reporting System…

  15. MICRO-VERS. Micro-computer Software for the Vocational Education Reporting System. User's Guide and Reference Manual. Version 3.1. Apple II.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This manual is intended to accompany a software system for the Apple II microcomputer that is designed to aid local districts in completing vocational education enrollment claims and Vocational Education Data System (VEDS) reports. Part I, Introduction, gives a brief overview of the Microcomputer Vocational Education Reporting System (MICRO-VERS),…

  16. A Comparative Analysis of the Relationships of Total Distribution Costs between Airlift and Sealift

    DTIC Science & Technology

    1974-01-16

    54 0. ORIGINATORS REPORT NUMUERISO 6. ROJCT O. /A 7 SR4-4A o.bI. OTm..iTR REPORT NO(Sl (Any pater, rnumepe that amay be sal Ved Al apert ) N/A 10...of Subsistence, and Quarters, Medical and Dental Expenses ..... • 2,160 Transportation and Handling of Supplies . • • . . . 442 Laundry Expenses

  17. A Study of the Relationship between Member Attitudes and Organizational Effectiveness in a Strategic Missile Wing (SAC) Operations Directorate.

    DTIC Science & Technology

    1978-09-01

    directly related to productivity and the ability to anticipate problems that might come up in the future., Tl research pr9ved that there are relationships...Vi. LIST OF FIGURES . .. .. .. .. .. . . .... vii Chapter I1. INTRODUCTION . . . . . . . . . . .* 1 Problem Statement . * . 2 Literature...Organizational Effectivenss ... .......... ... 8 2. Orthogonally Rotated Factors . . . . . . .. 28 3. Sample Canonical Correlaton Analysis Output . . 34 4

  18. Phylogenetic conservatism in plant phenology

    USGS Publications Warehouse

    Davies, T. Jonathan; Wolkovich, Elizabeth M.; Kraft, Nathan J. B.; Salamin, Nicolas; Allen, Jenica M.; Ault, Toby R.; Betancourt, Julio L.; Bolmgren, Kjell; Cleland, Elsa E.; Cook, Benjamin I.; Crimmins, Theresa M.; Mazer, Susan J.; McCabe, Gregory J.; Pau, Stephanie; Regetz, Jim; Schwartz, Mark D.; Travers, Steven E.

    2013-01-01

    Synthesis. Closely related species tend to resemble each other in the timing of their life-history events, a likely product of evolutionarily conser ved responses to environmental cues. The search for the underlying drivers of phenology must therefore account for species’ shared evolutionary histories.

  19. Evaluation of Epoxies to Provide Stress-Free Bonding of Pyroceram Mirrors.

    DTIC Science & Technology

    1979-03-01

    re-checked for distortion. In this case, the distortion remained at 6-7 fringes with a definite saddling of the surface. The only conclusion which...intorfesorar shown n Fig’ re 53, but the quntitative dOeqrad-lio ni TF could not be, predicted. Figure 55 is a plot of the MT-.’ responsce achie’ved for the

  20. Community College Journal for Research and Planning.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1981-01-01

    This journal, designed as a forum for the exchange of ideas among research and planning professionals, offers articles of research studies and practices. After Timothy Lightfield highlights upcoming professional association events, Janice S. Ancarrow's article, "The National Vocational Education Data Reporting and Accounting System (VEDS): Its…

  1. Hearings on Reauthorization of the Vocational Education Act of 1963. Part 10: Vocational Education Data System. Hearing before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor. House of Representatives. Ninety-Seventh Congress. First Session (December 10, 1981).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    This is a report of a hearing on December 10, 1981, before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor, House of Representatives, regarding reauthorization of the Vocational Education Act of 1963. It focuses on the vocational education data system known as VEDS. Testimony includes…

  2. Embolization of Life-Threatening Arterial Rupture in Patients with Vascular Ehlers–Danlos Syndrome

    SciTech Connect

    Okada, Takuya; Frank, Michael; Pellerin, Olivier Primio, Massimiliano Di Angelopoulos, Georgios; Boughenou, Marie-Fazia; Pagny, Jean-Yves; Messas, Emmanuel; Sapoval, Marc

    2013-05-09

    PurposeTo evaluate the safety and efficacy of transarterial embolization of life-threatening arterial rupture in patients with vascular Ehlers–Danlos syndrome (vEDS) in a single tertiary referral center.MethodsWe retrospectively analyzed transarterial embolization for vEDS performed at our institution from 2000 to 2012. The indication of embolization was spontaneous arterial rupture or pseudoaneurysm with acute bleeding. All interventions used a percutaneous approach through a 5F or less introducer sheath. Embolic agents were microcoils and glue in 3 procedures, glue alone in 2, and microcoils alone in 2.ResultsFive consecutive vEDS patients were treated by 7 embolization procedures (4 women, mean age 29.8 years). All procedures were successfully performed. Two patients required a second procedure for newly arterial lesions at a different site from the first procedure. Four of the five patients were still alive after a mean follow-up of 19.4 (range 1–74.7) months. One patient died of multiple organ failure 2 days after procedure. Minor procedural complications were observed in 3 procedures (43 %), all directly managed during the same session. Remote arterial lesions occurred after 3 procedures (43 %); one underwent a second embolization, and the other 2 were observed conservatively. Puncture site complication was observed in only one procedure (14 %).ConclusionEmbolization for vEDS is a safe and effective method to manage life-threatening arterial rupture.

  3. A Culture-Based Model for Strategic Implementation of Virtual Education Delivery

    ERIC Educational Resources Information Center

    Burn, Janice; Thongprasert, Nalinee

    2005-01-01

    This study was designed to examine the critical success factors for implementing Virtual Education Delivery (VED) in Thailand, and to identify ways to facilitate such adoption and lead to effective outcomes. The study incorporated an analysis of three specific factors related to Thai culture: high power distance "Bhun Khun", uncertainty…

  4. Tocotrienols are needed for normal bone calcification in growing female rats.

    PubMed

    Norazlina, Mohamed; Ima-Nirwana, Soelaiman; Abul Gapor, Mohd Top; Abdul Kadir Khalid, B

    2002-01-01

    In this study the effects of vitamin E deficiency and supplementation on bone calcification were determined using 4-month-old female Sprague-Dawley rats. The rats weighed between 180 and 200 g. The study was divided in three parts. In experiment I the rats were given normal rat chow (RC, control group), a vitamin E deficient (VED) diet or a 50% vitamin E deficient (50%VED) diet. In experiment 2 the rats were given VED supplemented with 30 mg/kg palm vitamin E (PVE30), 60 mg/kg palm vitamin E (PVE60) or 30 mg/kg pure alpha-tocopherol (ATF). In experiment 3 the rats were fed RC and given the same supplements as in experiment 2. The treatment lasted 8 months. Vitamin E derived from palm oil contained a mixture of ATF and tocotrienols. Rats on the VED and 50%VED diets had lower bone calcium content in the left femur compared to the RC group (91.6 +/- 13.3 mg and 118.3 +/- 26.0 mg cf 165.7 +/- 15.2 mg; P < 0.05) and L5 vertebra (28.3 +/- 4.0 mg and 39.5 +/- 6.2 mg compared with 51.4 +/- 5.8 mg; P < 0.05). Supplementing the VED group with PVE60 improved bone calcification in the left femur (133.6 +/- 5.0 mg compared with 91.6 +/- 13.3 mg; P < 0.05) and L5 vertebra (41.3 +/- 3.3 mg compared with 28.3 +/- 4.0 mg; P < 0.05) while supplementation with PVE30 improved bone calcium content in the L5 vertebra (35.6 +/- 3.1 mg compared with 28.3 +/- 4.0 mg; P < 0.05). However, supplementation with ATF did not change the lumbar and femoral bone calcium content compared to the VED group. Supplementing the RC group with PVE30, PVE60 or ATF did not cause any significant changes in bone calcium content. In conclusion, vitamin E deficiency impaired bone calcification. Supplementation with the higher dose of palm vitamin E improved bone calcium content, but supplementation with pure ATF alone did not. This effect may be attributed to the tocotrienol content of palm vitamin E. Therefore, tocotrienols play an important role in bone calcification.

  5. Pulsed Artificial Electrojet Generation

    NASA Astrophysics Data System (ADS)

    Papadopoulos, K.

    2008-12-01

    Traditional techniques for generating low frequency signals in the ULF/ELF range (.1-100 Hz) and rely on ground based Horizontal Electric Dipole (HED) antennas. It is, furthermore, well known that a Vertical Electric Dipole (VED) is by more than 50 dB more efficient than a HED with the same dipole current moment. However, the prohibitively long length of VED antennas in the ELF/ULF range coupled with voltage limitations due to corona discharge in the atmosphere make them totally impracticable. In this paper we discuss a novel concept, inspired by the physics of the equatorial electrojet, that allows for the conversion of a ground based HED to a VED in the E-region of the equatorial ionosphere with current moment comparable to the driving HED. The paper focuses in locations near the dip-equator, where the earth's magnetic is in predominantly in the horizontal direction. The horizontal electric field associated with a pulsed HED drives a large Hall current in the ionospheric E-region, resulting in a vertical current. It is shown that the pulsed vertical current in the altitude range 80-130 km, driven by a horizontal electric field of, approximately, .1 mV/m at 100 km altitude, is of the order of kA. This results in a pulsed VED larger than 106 A-m. Such a pulsed VED will drive ELF/ULF pulses with amplitude in excess of .1 nT at a lateral range larger than few hundred kilometers. This is by three orders of magnitude larger than the one expected by a HED with comparable current moment. The paper will conclude with the description of a sneak-through technique that allows for creating pulsed electric fields in the ionosphere much larger than expected from steady state oscillatory HED antennas.

  6. Molecular diagnosis in Vascular Ehlers-Danlos Syndrome Predicts Pattern of Arterial Involvement and Outcomes

    PubMed Central

    Shalhub, Sherene; Black, James H; Cecchi, Alana C.; Xu, Zhi; Griswold, Ben F; Safi, Hazim J; Milewicz, Dianna M.; McDonnell, Nazli B.

    2015-01-01

    OBJECTIVES The management of arterial pathology in individuals with vascular Ehlers-Danlos syndrome (vEDS) remains a challenge. Here we describe the correlation between COL3A1 gene mutation type and the clinical phenotype in individuals with vEDS. METHODS Individuals with confirmed molecular diagnoses of vEDS were enrolled in a multi institutional natural history study. Data collected included demographics, clinical and family histories, arterial pathology (aneurysm, dissection, and rupture), operative details, and autopsy reports. Individuals were classified into two cohorts based on the type of COL3A1 mutations and their effect on the amount of normal collagen produced: MIN group had mutations that lead to minimal (10–15%) production of normal type III collagen and HI group had haploinsufficiency mutations that lead to production of half the normal type III collagen. RESULTS A cohort of 68 (72%) individuals from 56 families had arterial pathology (44% male, 13% HI). The HI group was older at the time of their first vascular event (mean 42 years, range 26–58 vs. 33 years, range 8–62, P = .016). The HI group had a higher incidence of aortic pathology compared to the MIN group (56% vs. 21%. P = .025). Visceral arterial pathology was seen in 43 arteries in 23 individuals in the MIN group versus only a single artery in 5 individuals in the HI group. Emergent surgical procedures were more likely to be undertaken when vEDS diagnosis was not known (81% vs. 41%, P = .005) and the majority of these procedures were open surgical repair compared to endovascular repair (81% vs. 19%, P = .019). In the elective setting, there was equal use of open and endovascular repair. Post-operative complications were highest when the diagnosis of vEDS was not known (62% vs. 14%, P < .001) and when procedures were undertaken in an emergency setting (5% vs. 55% P < .001). There was no mortality due to arterial complications in the HI cohort and 21% in the MIN cohort (P = .132

  7. Peculiarities of the C2d3Π→a3Π band system intensities in gas discharges through CO-contained mixtures

    NASA Astrophysics Data System (ADS)

    Grigorian, G. M.

    2012-12-01

    The paper discusses the experimental results pointing to the efficient channel of the CO vibrational to the C2 electronic energy-transfer. The radiation spectra of the d3Πg electronic state of C2 molecule are investigated and the relation of their kinetics to a vibrational excitation of CO molecules in the He-CO-O2 plasma is discussed. The changes of CO vibrational energy distribution (VED) were imposed by an application of a laser resonator to the discharge tube under investigation. It was found that the modulation of laser radiation (and VED) led to a similar changes of the spontaneous radiation from d3Πg state of C2 molecules

  8. Introducing cholera vaccination in Asia, Africa and Haiti: a meeting report.

    PubMed

    Hall, Robert H; Sack, David A

    2015-01-15

    Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with OCV under nine distinctive field settings was reported from India, Bangladesh, Vietnam, Guinea, Haiti, and Thailand. Lead investigators from each of these projects presented their findings at a symposium chaired by Drs. David A. Sack and Robert H. Hall at the Vaccines for Enteric Diseases (VED) Conference in Bangkok on November 7, 2013. The objective of the symposium was to describe the unique features of each setting and project, share field experience of implementing cholera vaccination, discuss results, and identify constraints to the wider use of OCV. The VED provided a forum where >200 attendees engaged with this exciting and potentially decisive new development in the cholera field.

  9. Thermo-Mechanical Stress in High-Frequency Vacuum Electron Devices

    NASA Astrophysics Data System (ADS)

    Gamzina, Diana; Luhmann, Neville C.; Ravani, Bahram

    2017-01-01

    Analysis of the thermo-mechanical performance of high-frequency vacuum electron devices is essential to the advancement of RF sources towards high-power generation. Operation in an ultra-high vacuum environment, space restricting magnetic focusing, and limited material options are just some of the constraints that complicate thermal management in a high-power VED. An analytical method for evaluating temperature, stress, and deformation distribution in thin vacuum-to-cooling walls is presented, accounting for anisotropic material properties. Thin plate geometry is used and analytical expressions are developed for thermo-mechanical analysis that includes the microstructure effects of grain orientations. The method presented evaluates the maximum allowable heat flux that can be used to establish the power-handling limitation of high-frequency VEDs prior to full-scale design, accelerating time-to-manufacture.

  10. Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function.

    PubMed

    Basal, Seref; Wambi, Chris; Acikel, Cengizhan; Gupta, Mantu; Badani, Ketan

    2013-04-01

    WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Removing of prostate for the treatment of localized prostate cancer is associated with a variable loss of erectile function due to injury of the nerves of erection during operation. Some researchers have reported that after nerve-sparing radical prostatectomy (RP), the natural recovery time of erectile function is at least 2 years. Factors such as thermal damage, ischaemic injury, mechanically induced nerve stretching and the local inflammatory effects of surgical trauma may also impair the cavernous nerves during RP. The concept of penile rehabilitation was first studied by Montorsi et al. in 1997. They showed that the use of any drug or device at or after RP could maximize the recovery of erectile function. Penile rehabilitation programmes (PRPs) with vasoactive agents, such as oral phosphodiesterase-5 inhibitors (PDE5Is), intraurethral and intracavernosal vasoactive agents, and vacuum erection devices (VEDs) can protect erectile tissue integrity and prevent corporal smooth muscle atrophy and diminish collagen formation. The present findings are consistent with previous reports that PRPs have a significant beneficial effect on early erectile function recovery and that preoperative erectile function is one of the important predictors of erectile function after RP. Patients can be referred for penile rehabilitation if they have any degree of erectile function (mild, moderate or normal) before operation. We also showed that the combination of PDE5Is and VEDs for PRPs offers the shortest erectile function recovery period. To define the optimal penile rehabilitation programme (PRP) based on preoperative Sexual Health Inventory for Men (SHIM) scores after robot-assisted radical prostatectomy (RARP). The medical records of 203 patients who underwent bilateral nerve-sparing RARP between 2007 and 2011 were reviewed for the present retrospective study. According to patients' preoperative erection status, group 1

  11. Micromachined TWTs for THz Radiation Sources

    NASA Technical Reports Server (NTRS)

    Booske, John H.; vanderWeide, Daniel W.; Kory, Carol L.; Limbach, S.; Downey, Alan (Technical Monitor)

    2001-01-01

    The Terahertz (THz) region of the electromagnetic spectrum (about 300 - 3000 GHz in frequency or about 0.1 - 1 mm free space wavelength) has enormous potential for high-data-rate communications, spectroscopy, astronomy, space research, medicine, biology, surveillance, remote sensing, industrial process control, etc. It has been characterized as the most scientifically rich, yet under-utilized, region of the electromagnetic spectrum. The most critical roadblock to full exploitation of the THz band is lack of coherent radiation sources that are powerful (0.001 - 1.0 W continuous wave), efficient (> 1%), frequency agile (instantaneously tunable over 1% bandwidths or more), reliable, and comparatively inexpensive. To develop vacuum electron device (VED) radiation sources satisfying these requirements, fabrication and packaging approaches must be heavily considered to minimize costs, in addition to the basic interaction physics and circuit design. To minimize size of the prime power supply, beam voltage must be minimized, preferably 10 kV. Solid state sources satisfy the low voltage requirement, but are many orders of magnitude below power, efficiency, and bandwidth requirements. On the other hand, typical fast-wave VED sources in this regime (e.g., gyrotrons, FELs) tend to be large, expensive, high voltage and very high power devices unsuitable for most of the applications cited above. VEDs based on grating or inter-digital (ID) circuits have been researched and developed. However, achieving forward-wave amplifier operation with instantaneous fractional bandwidths > 1% is problematic for these devices with low-energy (< 15 kV) electron beams. Moreover, the interaction impedance is quite low unless the beam-circuit spacing is kept particularly narrow, often leading to significant beam interception. One solution to satisfy the THz source requirements mentioned above is to develop micromachined VEDs, or "micro-VEDs". Among other benefits, micro-machining technologies

  12. A Multidisciplinary Study of Ciguatoxin and Related Low Molecular Weight Toxins from Marine Source

    DTIC Science & Technology

    1986-08-01

    viscera (liver and intestines) of guinea pigs, and the fruit of the avocado . Authentic ClX ws not available at the time the experiments outlined below...iully Treatmet of the tissues with attract~s from tilapiao, kale,. guines, pig viscera and avocado produced respnes slimilar to those ctain’ved with...all ultimately caused death. Avocado extract differad only in the anmumt necessary to procduce these effects, 80 - 100 ug/kg in two animals. Copy .c

  13. Design Methodology and Experimental Verification of Serpentine/Folded Waveguide TWTs

    DTIC Science & Technology

    2016-03-17

    integration into the amplifier. The first of these is a small beam tunnel offset relative to the circuit bends, and the second is the slightly smaller... circuit topologies, which permit greater design flexibility than the basic serpen- tine/FW topologies, are also introduced, and their dispersion...challenging due to uncertainties in the fabrication and assembly of these small RF circuits . Serpentine and folded-waveguide (FW) TWTs are a class of VEDs

  14. High Power Density Spray Cooling

    DTIC Science & Technology

    1989-07-01

    storage causing a large surface tanperature increase. In this case, the surface temperature quickly excee the Leidenfrost taperature, and the surface become...heat content of the liquid on the heat transfer rate at surface temperatures below the Leidenfrost point. All ccmparisons are in the form of total...experiment. lpariments were begun at roam temperature and ramVed up continuously until Leidenfrost conditions were reached, after which the heaters were

  15. Coordinated Research Program in Pulsed Power Physics.

    DTIC Science & Technology

    1981-12-01

    LASER LABORATORY Department of Electrical Engineering TEXAS TECH UNIVERSJ Lubbock, Texas 79409 2c e pproVed f or ii ~~distribution ulmtd Unclassified...Department of Electrical Engineering Texas Tech University 230A7 Lubbock, Texas 79409 0/--/-77 II. CONTROLLING OFFICE NAME AND ADDRESS 12, REPORT DATE 14...Phenomena ..... .. 40 Project No. 4: Pulsed Power Surface Physics and Applications . 84 Project No. 5: Excited State Spectroscopy of Electrically Excited

  16. Shift and Scale Invariant Preprocessor.

    DTIC Science & Technology

    1981-12-01

    1982 THESIS D V SHIFT AND SCALE INVARIANT ?PREPROCESSOR by Norman E. Huston, Jr. December 1981 0 Thesis Advisor: L. A. Wilson Approved for public...SCHOOL December 1981 Author: - . 4 ,/ A pp ro0ved by: rYY. ( Thesis Advisor Co-Ad isor Chairman, De artment of 4n n eing Dean of Science and...large range of problems/disciplines. Fields where it is particularly common include optical imagery, acoustic signal processing , radiology, radio

  17. Verbal Emotional Disclosure of Traumatic Experiences in Adolescents: The Role of Social Risk Factors

    PubMed Central

    Pérez, Silvia; Peñate, Wenceslao; Bethencourt, Juan M.; Fumero, Ascensión

    2017-01-01

    It is well-known that traumatic events and adverse life situations are very important in both physical and psychological health. Prevalence studies suggested that adolescents experience at least one potentially traumatic event before reaching age 18. The paradigm of research centered on expressive writing has evidenced the beneficial effects that the emotional disclosure of previous traumas produces on physical health and psychological adjustment. The aims of the study are threefold: determining the prevalence of adverse or traumatic events; examining the extent to which psychopathological symptoms developed in those exposed to traumatic events; and exploring an verbal emotional disclosure (VED) paradigm in which variations on time spent talking about traumatic experiences to others resulted in a reduction of the psychological impact of trauma in a sample of Spanish adolescents. 422 volunteer adolescents participated, 226 boys and 192 girls, from 10 to 19 years old, all of them living in Tenerife. The mean age was 14.8 years (SD = 1.83). All of them completed the instruments used to assess the psychological impact of traumatic experiences and VED. The main results indicated that 77% of the participants had suffered a traumatic situation. The participants who have been exposed to traumatic events scored significantly higher in measures of post-traumatic stress, disorder, intrusive thoughts, avoidance behaviors, anxiety and depression, compared to those without trauma. Furthermore, results show a decrease in symptomatology scores as a function of time spent disclosing emotional experiences to others, particularly when disclosure occurred several times. In conclusion, stressful events or traumatic experiences and their concomitant emotional effects are highly prevalent in adolescents, and repeated VED to others appears to ameliorate their impact. VED shows greater therapeutic benefits when adolescents narrate the experience on several occasions and in an extensive way

  18. An Analysis of the Air Force Logistics Command (AFLC) Forecasting Method for Predicting Second Destination Transportation (SDT)

    DTIC Science & Technology

    1989-09-01

    Boston: PWS-Kent Publishing Company, 1988. 17. Pindyck , Robert S. and Daniel L. Rubinfeld. Econometric Models and Economic Forecasts (Second Edition...Mr. George T. Menker and his staff at HQ AFLC/DSXR. I am also deeply indebted to my advisor and friend Lt Col Robert E. Trempe for his technical...number) Thesis Advisor: Robert E. Trempe, Lt Col, USAF Instructor in Logistics Management Department of Logistics Management Appr ved for p lic re ease

  19. Forecasting Device Effectiveness. Volume 2. Procedures

    DTIC Science & Technology

    1985-06-01

    18 months, but who have not ser- ved as gunners. Alternatively, they might be enlistees who have just finished Basic Combat Training (BCT) and on the...34 trouble-shooting a complex : piece of equipment. Consider the number of internal decisions or calculations that must be made in choosing your answer...training system chunk: the material to be learned into small blocks or steps appropriate to the complexity of the subtas:S (tasks) and the capabilities

  20. A Large-Scale Quantitative Proteomic Approach to Identifying Sulfur Mustard-Induced Protein Phosphorylation Cascades

    DTIC Science & Technology

    2010-01-01

    Maryland 21010 ReceiVed July 31, 2009 Probing the Dynamic Effect of Cys-CdTe Quantum Dots toward Cancer Cells in Vitro. See article on pp 82–88...specific proteins, such as p53, NF-κB, Bcl- 2, and others (1). While these studies are effective at probing individual pathways, they do not put into... effective at answering a range of biological questions, from targeted studies to global analyses. For example, metabolic labeling approaches such as stable

  1. Problem Solving and Reasoning

    DTIC Science & Technology

    1988-01-01

    response fre- of homework or test problems that the class was lems were esented quencies in two tasks. Findings that fit this working on at the time...psychological models were th this students who receive these tasks as homework simpler, and the inferences about processes ved by assignments and...quantitative relations study of children from kindergarten through and stud, nts must be able to choose formulas third grade. The versions differ in

  2. The novel role of fenofibrate in preventing nicotine- and sodium arsenite-induced vascular endothelial dysfunction in the rat.

    PubMed

    Kaur, Jagdeep; Reddy, Krishna; Balakumar, Pitchai

    2010-09-01

    The present study investigated the effect of fenofibrate, an agonist of PPAR-alpha, in nicotine- and sodium arsenite-induced vascular endothelial dysfunction (VED) in rats. Nicotine (2 mg/kg/day, i.p., 4 weeks) and sodium arsenite (1.5 mg/kg/day, i.p., 2 weeks) were administered to produce VED in rats. The scanning electron microscopy study in thoracic aorta revealed that administration of nicotine or sodium arsenite impaired the integrity of vascular endothelium. Further, administration of nicotine or sodium arsenite significantly decreased serum and aortic concentrations of nitrite/nitrate and subsequently reduced acetylcholine-induced endothelium-dependent relaxation. Moreover, nicotine or sodium arsenite produced oxidative stress by increasing serum thiobarbituric acid reactive substances (TBARS) and aortic superoxide generation. However, treatment with fenofibrate (30 mg/kg/day, p.o.) or atorvastatin (30 mg/kg/day p.o., a standard agent) significantly prevented nicotine- and sodium arsenite-induced VED and oxidative stress by improving the integrity of vascular endothelium, increasing the concentrations of serum and aortic nitrite/nitrate, enhancing the acetylcholine-induced endothelium-dependent relaxation and decreasing serum TBARS and aortic superoxide anion generation. Conversely, co-administration of L-NAME (25 mg/kg/day, i.p.), an inhibitor of nitric oxide synthase, markedly attenuated these vascular protective effects of fenofibrate. The administration of nicotine or sodium arsenite altered the lipid profile by increasing serum cholesterol and triglycerides and consequently decreasing high-density lipoprotein levels, which were significantly prevented by treatment with fenofibrate or atorvastatin. It may be concluded that fenofibrate improves the integrity and function of vascular endothelium, and the vascular protecting potential of fenofibrate in preventing the development of nicotine- and sodium arsenite-induced VED may be attributed to its

  3. Comparison of a Follow-On Analysis and Initial Findings of a Survey of the Perceived Quality of Life of Air Force People

    DTIC Science & Technology

    1979-09-07

    being, his satis- faction or dissatisfaction with life , or happiness or unhappiness [17:11]. Dr. Ben-Chieh Liu has defined QOL as: . . . the output...FOLLOW-ON ANALYSIS AND INITIAL FINDINGS OF A SURVEY OF THE PERCEIVED QUALITY OF LIFE OF AIR FORCE PEOPLE , /•’ / William L./George; Captain...A FOLLOW-ON ANALYSIS AND INITIAL FINDINGS OF A SURVEY OF THE PERCLiVED QUALITY OF LIFE OF AIR FORCE PEOPLE 5 TYPE OF REPORT & PERIOO COVERED

  4. Two-Dimensional Confined Jet Thrust Vector Control: Operating Mechanisms and Performance

    DTIC Science & Technology

    1989-03-01

    Avdilability Codes Nsf / AvduI and Ior 4 01st Specia Appr-ved for public release; distribution unlimited Pr ef ace In this thesis, I continued the...exceptionally high quality test articles, also with impossible deadlines. - the von Karman Institute, Dr. M. Carbonaro provided me with theoretical and...Schlieren photographs and video tapes were used to study flow separation and internal shock structures. Nozzle performance parameters were determined for

  5. Assessment of Benefits and Drawbacks of Using Fuzzy Logic, Especially in Fire Control Systems

    DTIC Science & Technology

    1994-03-01

    classitied by :W. Pelt classitication date :September 20, 1993 jp:op:ved ci.’ :::: - - - - title :ongerubriceerd manage mentuittreksel :Ongerubriceerd...kanonsysteem het gebruik van "fuzzy reasoning" technieken voorkwam. Dit voorstel is gedaan door SIGNAAL, in een opdracht van de KM. Het TNO-FEL had een...van bet gebruik van fuzzy logic in vergelijking met ’conventionele’ methoden. Geconcludeerd wordt dat er in principe goede mogelijkhieden voor

  6. An Implementation of Wavelet Analysis

    DTIC Science & Technology

    1993-07-01

    CLASSIFIED AD-A273 162 * DISTO High Frequency, RAdar Pivilsion TECHNICAL REPORT SRL-0122-TR AN IMPLEMENTATION OF WAVELET ANALYSIS by DTIC C.J...Coleman ELECTE 0 EE1 I II, 44 H 93-28032 Tilldl I ~APPRO VED FOR PUBLIC RELEASE I UNCLASSIFIED l UNCLASSIFIED DSTOAV A U S T R A L I A SURVEILLANCE...5 6 SIGNAL STRUCTURE .................................................. 9 7 CO NCLUSIO N S

  7. Qualification Test Report. Fuel Pump Test Stand. 3C3965G05

    DTIC Science & Technology

    1991-10-01

    ACTION REQESTS XII. OONCUB ICNS APPEDIX A. VED ORR ATION TESY D SHEETS APPENDIX B. EEFINITICN OF tUt CREA I=CN LIMITS APPENDIX C. CRREATION ETA...LO-DISCH. OPM P4-FIL OUT PSIO T4mIGV INLET - BYPASS OPM PS-DZSCH. PSI0 TSmDISCH. Q3 - IGV IN OPM P6-FIL BPV PSID T&mCELL AM1. r = SERVO RET. GPM

  8. Implementation Document for Groundwater Intercept and Treatment System, Basin A Neck IRA. Volume 3: Engineering Drawings

    DTIC Science & Technology

    1989-08-01

    OR 1-000 LB. CONCENTRATED MOVING LOAD) 0. TOPOGRAPHICAL DATA IS ’ lEAN SEA -F4EL AND BASES .’.N OPERATING AND EQUIPMENT LAYDOAN AREA FLOORS = 250 osf...INEER APPR VED EQUAL) OINIE06 EQIPEN VNRY WIS EC0,OJPIE SEETI6 ."󈧒i)Vil 1ý21 3L SALE DSPLA LOO 6E T t CTER 20.. SAL.TV CAPAITY aE MANUFACTURIN CO

  9. The Shaped Charge Concept. Part 2. The History of Shaped Charges

    DTIC Science & Technology

    1990-09-01

    was called lde Beethoven and had a disamee of 180 an with 5,000 kg of high explosive. The Beethoven was designed for ums against ships mnd ground...foificauions. During the Normandy invasion, the Beethoven destroyed two batleships and four large uumrport ships. The Beethoven was the formunnir of die...large Gennan holov charge called the "MISTERIE?" (This is undoubtedl) the MISTEL which evo ved fhom the Beethoven charge discussed earlier). From the

  10. Verbal Emotional Disclosure of Traumatic Experiences in Adolescents: The Role of Social Risk Factors.

    PubMed

    Pérez, Silvia; Peñate, Wenceslao; Bethencourt, Juan M; Fumero, Ascensión

    2017-01-01

    It is well-known that traumatic events and adverse life situations are very important in both physical and psychological health. Prevalence studies suggested that adolescents experience at least one potentially traumatic event before reaching age 18. The paradigm of research centered on expressive writing has evidenced the beneficial effects that the emotional disclosure of previous traumas produces on physical health and psychological adjustment. The aims of the study are threefold: determining the prevalence of adverse or traumatic events; examining the extent to which psychopathological symptoms developed in those exposed to traumatic events; and exploring an verbal emotional disclosure (VED) paradigm in which variations on time spent talking about traumatic experiences to others resulted in a reduction of the psychological impact of trauma in a sample of Spanish adolescents. 422 volunteer adolescents participated, 226 boys and 192 girls, from 10 to 19 years old, all of them living in Tenerife. The mean age was 14.8 years (SD = 1.83). All of them completed the instruments used to assess the psychological impact of traumatic experiences and VED. The main results indicated that 77% of the participants had suffered a traumatic situation. The participants who have been exposed to traumatic events scored significantly higher in measures of post-traumatic stress, disorder, intrusive thoughts, avoidance behaviors, anxiety and depression, compared to those without trauma. Furthermore, results show a decrease in symptomatology scores as a function of time spent disclosing emotional experiences to others, particularly when disclosure occurred several times. In conclusion, stressful events or traumatic experiences and their concomitant emotional effects are highly prevalent in adolescents, and repeated VED to others appears to ameliorate their impact. VED shows greater therapeutic benefits when adolescents narrate the experience on several occasions and in an extensive way.

  11. Analysis of in vitro skin permeation of 22-oxacalcitriol having a complicated metabolic pathway.

    PubMed

    Yamaguchi, Koji; Mitsui, Tetsuya; Yamamoto, Toshinori; Shiokawa, Rie; Nomiyama, Yuko; Ohishi, Norihisa; Aso, Yoshinori; Sugibayashi, Kenji

    2006-04-01

    The purpose of this study is to analyze simultaneous skin permeation and metabolism of 22-oxacalcitriol (OCT) having several metabolites in skin by observing skin permeation of only unchanged OCT through excised rat skin. A diffusion model including metabolic processes was employed to express simultaneous skin permeation and metabolism of OCT. In vitro permeation experiments of OCT from Oxarol ointment through full-thickness and stripped rat skin were carried out using Franz-type diffusion cells. Time courses of unchanged OCT amounts in ointment, skin, and receptor fluid were determined and fitted to diffusion equations to obtain permeation parameters and a metabolic rate. Fitting curves of the skin permeation profile obtained by the model were sufficiently close to observed data of unchanged OCT amounts in ointment, skin, and receptor fluid. The following parameters were obtained: metabolic rate of 1.37 x 10(-1) h(-1), and diffusion constants of OCT in stratum corneum (SC) (D(SC)) and viable epidermis and dermis (VED) (D(VED)) of 1.50 x 10(-7) and 2.96 x 10(-4) cm2/h, respectively. The partition coefficient of OCT for SC/ointment (K(SC/D)) was 7 times greater than that of VED/ointment (K(VED/D)). The present analysis made it possible to calculate skin permeation parameters (partitioning, diffusivity, and metabolic rate) of OCT without requiring metabolic information, e.g., quantification of metabolites or identification of metabolic pathways. This would be widely applicable for drugs that are not suitable for conventional methods due to complicated metabolic pathways.

  12. Group Selection Methods and Contribution to the West Point Leadership Development System (WPLDS)

    DTIC Science & Technology

    2015-08-01

    Network Science Center Approved for public release; distribution is unlimited. U.S. Military...Academy Network Science Center Authorized a ~ ved for distribution: ~ WILLIAM PULllEYBLANK, Ph.D. /l~j) L fuA~oNY HNSON, Ph.D. Network Science ...Center Chair Director, Network Science Center Technical review by COL Howard D. Mcinvale, Ph.D., Department of Mathematical Sciences , U.S. Military

  13. The CCTC Quick-Reacting General War Gaming System (QUICK) Users Manual. Volume 3. Weapon Allocation Subsystem

    DTIC Science & Technology

    1978-04-15

    GENERAL Ld WAR GAMING SYSTEM (QUICK) VOLUME III WEAFON ALLOCATION SUBSYSTEM DEFENSE USERS MANUAL COMMUNICATIONS AGENCY FTHIS 2OCUP.ENT HiAS E APP)VED...GAMING SYSTEM Volume III Weapon Allocation Subsystem. SUBMITTED Bl("--- APPROVED BY: Q)C.. IIOMPSON 1ED EI A. RAF, . " Project Officel Captain, U.S...Volume III , provides detailed instructions for execution of the Weapon Allocatirn Subsystem and the modules it comprises. Companion documents are: a

  14. A Design-Aid and Cost Estimate Model for Suppressive Shielding Structures

    DTIC Science & Technology

    1975-12-01

    Dou.-ar-tmelrit Of the Army. Tns0ni has been reviewed aniid isý -a7pro-ved for relase Fr Lurther informlation on this. pr-oject contact Dr . Ccorr--e L...5 Ivaterial Parameters ......... .. 00. .......... 5 Economic Parameters . ........ . ................... . 6 The Cost Equation...pipes, etc. (sae Appendix B) The economic value of suppressive structures must be determiined before they can replace the concrete barriers. An economic

  15. Vestibular nuclei characterized by calcium-binding protein immunoreactivity and tract tracing in Gekko gecko

    PubMed Central

    Song, Jing; Wang, Wenbo; Carr, Catherine E.; Dai, Zhendong; Tang, Yezhong

    2014-01-01

    Immunohistochemical techniques were used to describe the distribution of the calcium binding proteins calretinin, calbindin and parvalbumin as well as synaptic vesicle protein 2 in the vestibular nuclei of the Tokay gecko (Gekko gecko). In addition, tract tracing was used to investigate connections between the vestibular nerves and brainstem nuclei. Seven vestibular nuclei were recognized: the nuclei cerebellaris lateralis (Cerl), vestibularis dorsolateralis (Vedl), ventrolateralis (Vevl), ventromedialis (Vevm), tangentialis (Vetg), ovalis (VeO) and descendens (Veds). Vestibular fibers entered the brainstem with the ascending branch projecting to Vedl and Cerl, the lateral descending branch to Veds, and the medial descending branch to ipsilateral Vevl. Cerl lay most rostral, in the cerebellar peduncle. Vedl, located rostrally, was ventral to the cerebellar peduncle, and consisted of loosely arranged multipolar and monopolar cells. Vevl was found at the level of the vestibular nerve root and contained conspicuously large cells and medium-sized cells. Veds is a large nucleus, the most rostral portion of which is situated lateral and ventral to Vevl, and occupies much of the dorsal brainstem extending caudally through the medulla. VeO is a spherically shaped cell group lateral to the auditory nucleus magnocellularis and dorsal to the caudal part of Vevl. Vevm and Vetg were small in the present study. Except for VeO, all other vestibular nuclei appear directly comparable to counterparts in other reptiles and birds based on their location, cytoarchitecture, and connections, indicating these are conserved features of the vestibular system. PMID:23201031

  16. Vacuum erection device in treatment of organic erectile dysfunction and penile vascular differences between patients with DM type I and DM type II.

    PubMed

    Pajovic, Bogdan; Dimitrovski, Antonio; Fatic, Nikola; Malidzan, Milos; Vukovic, Marko

    2017-03-01

    The aim of this study is to investigate changes in the vascular system and hemodynamics between patients with organic erectile dysfunction (ED) (DM type I and II), as well as to compare the quality of sexual life between those two groups after the treatment with vacuum erection device (VED). Study enrolled 50 males with DM, aged from 35 to 67 years, who have attended the urologic clinic due to inability to attain and maintain an erection of the penis sufficient to permit satisfactory sexual intercourse. Patients were using VED and six months later were assessed for therapy results. The International Index of Erectile Function (IIEF) was used to quantify erectile dysfunction. Alprostadil injection test was also used, with Doppler color flow imaging system, to evaluate the peak systolic velocity (PSV) and diameter of cavernosal artery (DCA). Significantly higher values of PSV were obtained in patients with DM type II. Also, DCA showed significant difference between two groups of patients. There was significant improvement in three items of IIEF after six months of treatment among both groups of examinees. Patients with DM type I had more serious risk for development of arteriogenic ED. VED could be a good alternative therapy for patients who denied peroral therapy.

  17. Vessel Enhancement and Segmentation of 4D CT Lung Image Using Stick Tensor Voting

    NASA Astrophysics Data System (ADS)

    Cong, Tan; Hao, Yang; Jingli, Shi; Xuan, Yang

    2016-12-01

    Vessel enhancement and segmentation plays a significant role in medical image analysis. This paper proposes a novel vessel enhancement and segmentation method for 4D CT lung image using stick tensor voting algorithm, which focuses on addressing the vessel distortion issue of vessel enhancement diffusion (VED) method. Furthermore, the enhanced results are easily segmented using level-set segmentation. In our method, firstly, vessels are filtered using Frangi's filter to reduce intrapulmonary noises and extract rough blood vessels. Secondly, stick tensor voting algorithm is employed to estimate the correct direction along the vessel. Then the estimated direction along the vessel is used as the anisotropic diffusion direction of vessel in VED algorithm, which makes the intensity diffusion of points locating at the vessel wall be consistent with the directions of vessels and enhance the tubular features of vessels. Finally, vessels can be extracted from the enhanced image by applying level-set segmentation method. A number of experiments results show that our method outperforms traditional VED method in vessel enhancement and results in satisfied segmented vessels.

  18. Candidate THz sources: The history and future (?) of velocity-modulated devices

    NASA Astrophysics Data System (ADS)

    Lee, Thomas H.

    2006-02-01

    Compelling applications for terahertz technology include medical diagnostics and imaging, extremely wideband communication (XWB), pollution monitoring and security threat detection. One impediment is a lack of practical sources in the 1-10THz frequency range. Room-temperature CW operation, high spectral purity, tunability, and power levels above the milliwatt range are additional requirements that compound the challenge. Continued scaling of feature sizes will enable traditional semiconductor devices to provide good small-signal performance at THz frequencies, but practically obtaining the desired output power levels is much less certain. Traditional coherent optical sources encounter downward frequency scaling difficulties as the energy state differences approach 25meV (corresponding to approximately 6THz, or 50μm free-space wavelength). Electronic devices dependent on velocity modulation obey rather different scaling laws and are strong candidates for bridging the "terahertz gap." As relatively few contemporary engineers are familiar with vacuum electronic devices (VEDs), and fewer still with velocity modulation, this paper reviews the history of velocity-modulated VEDs, starting with the observations of Barkhausen and Kurz in 1919, and proceeding to practical devices, such as the klystron, magnetron, traveling-wave tube (TWT) and backward-wave oscillator (BWO). We additionally consider how modern process technology enables a reconceiving of classical VEDs to produce devices capable of practical operation in the 1-10THz region.

  19. Size distribution and source of black carbon aerosol in urban Beijing during winter haze episodes

    NASA Astrophysics Data System (ADS)

    Wu, Yunfei; Wang, Xiaojia; Tao, Jun; Huang, Rujin; Tian, Ping; Cao, Junji; Zhang, Leiming; Ho, Kin-Fai; Han, Zhiwei; Zhang, Renjian

    2017-06-01

    Black carbon (BC) has important impact on climate and environment due to its light absorption ability, which greatly depends on its physicochemical properties including morphology, size and mixing state. The size distribution of the refractory BC (rBC) was investigated in urban Beijing in the late winter of 2014, during which there were frequent haze events, through analysis of measurements obtained using a single-particle soot photometer (SP2). By assuming void-free rBC with a density of 1.8 g cm-3, the mass of the rBC showed an approximately lognormal distribution as a function of the volume-equivalent diameter (VED), with a peak diameter of 213 nm. Larger VED values of the rBC were observed during polluted periods than on clean days, implying an alteration in the rBC sources, as the size distribution of the rBC from a certain source was relative stable, and VED of an individual rBC varied little once it was emitted into the atmosphere. The potential source contribution function analysis showed that air masses from the south to east of the observation site brought higher rBC loadings with more thick coatings and larger core sizes. The mean VED of the rBC presented a significant linear correlation with the number fraction of thickly coated rBC, extrapolating to be ˜ 150 nm for the completely non-coated or thinly coated rBC. It was considered as the typical mean VED of the rBC from local traffic sources in this study. Local traffic was estimated to contribute 35 to 100 % of the hourly rBC mass concentration with a mean of 59 % during the campaign. Lower local traffic contributions were observed during polluted periods, suggesting increasing contributions from other sources (e.g., coal combustion and biomass burning) to the rBC. Thus, the heavy pollution in Beijing was greatly influenced by other sources in addition to the local traffic.

  20. Predictive modeling of slope deposits and comparisons of two small areas in Northern Germany

    NASA Astrophysics Data System (ADS)

    Shary, Peter A.; Sharaya, Larisa S.; Mitusov, Andrew V.

    2017-08-01

    Methods for correct quantitative comparison of several terrains are important in the development and use of quantitative landscape evolution models, and they need to introduce specific modeling parameters. We introduce such parameters and compare two small terrains with respect to the link slope-valley for the description of slope deposits (colluvium) in them. We show that colluvium accumulation in small areas cannot be described by linear models and thus introduce non-linear models. Two small areas, Perdoel (0.29 ha) and Bornhöved (3.2 ha), are studied. Slope deposits in the both are mainly in dry valleys, with a total thickness Mtotal up to 2.0 m in Perdoel and up to 1.2 m in Bornhöved. Parent materials are mainly Pleistocene sands aged 30 kyr BP. Exponential models of multiple regression that use a 1-m LiDAR DEM (digital elevation model) explained 70-93% of spatial variability in Mtotal. Parameters DH12 and DV12 of horizontal and vertical distances are introduced that permit to characterize and compare conditions of colluvium formation for various terrains. The study areas differ 3.7 times by the parameter DH12 that describes a horizontal distance from thalwegs at which Mtotal diminishes 2.72 times. DH12 is greater in Bornhöved (29.7 m) than in Perdoel (8.12 m). We relate this difference in DH12 to the distinction between types of the link slope-valley: a regional type if catchment area of a region outside a given small area plays an important role, and a local type when accumulation of colluvium from valley banks within a small area is of more importance. We argue that the link slope-valley is regional in Perdoel and local in Bornhöved. Peaks of colluvium thickness were found on thalwegs of three studied valleys by both direct measurements in a trench, and model surfaces of Mtotal. A hypothesis on the formation mechanism of such peaks is discussed. The parameter DV12 describes a vertical distance from a peak of colluvium thickness along valley bottom at

  1. Skeletal muscle morphology, protein synthesis, and gene expression in Ehlers-Danlos syndrome.

    PubMed

    Nygaard, Rie H; Jensen, Jakob K; Voermans, Nicol C; Heinemeier, Katja M; Schjerling, Peter; Holm, Lars; Agergaard, Jakob; Mackey, Abigail L; Andersen, Jesper L; Remvig, Lars; Kjaer, Michael

    2017-08-01

    Patients with Ehlers-Danlos syndrome (EDS) are known to have genetically impaired connective tissue and skeletal muscle symptoms in form of pain, fatigue, and cramps; however earlier studies have not been able to link these symptoms to morphological muscle changes. We obtained skeletal muscle biopsies in patients with classic EDS [cEDS; n = 5 (Denmark)+ 8 (The Netherlands)] and vascular EDS (vEDS; n = 3) and analyzed muscle fiber morphology and content (Western blotting and muscle fiber type/area distributions) and muscle mRNA expression and protein synthesis rate (RT-PCR and stable isotope technique). The cEDS patients did not differ from healthy controls (n = 7-11) with regard to muscle fiber type/area, myosin/α-actin ratio, muscle protein synthesis rate, or mRNA expression. In contrast, the vEDS patients demonstrated higher expression of matrix proteins compared with cEDS patients (fibronectin and MMP-2). The cEDS patients had surprisingly normal muscle morphology and protein synthesis, whereas vEDS patients demonstrated higher mRNA expression for extracellular matrix remodeling in skeletal musculature compared with cEDS patients.NEW & NOTEWORTHY This study is the first of its kind to systematically investigate muscle biopsies from Ehlers-Danlos patients, focusing on muscle structure and function. These patients suffer from severe muscle symptoms, but in our study they show surprisingly normal muscle findings, which points toward indirect muscle symptoms originating from the surrounding connective tissue. These findings have basal physiological importance and implications for future physiotherapeutic treatment options for these patients. Copyright © 2017 the American Physiological Society.

  2. [Gerontological profile of an elderly population in Tabasco, México].

    PubMed

    Guerrero-Pérez, Ramiro; Quevedo-Tejero, Elsy Del Carmen; García-Rochín, Ramón; Zavala-González, Marco A

    2012-01-01

    Defining the gerontological profile of an elderly population in Tabasco, Mexico. This was an observational, retrospective, cross-sectional, descriptive study. The study population consisted of 35,745 elderly adults who were enrolled in the Mexican Older Adults' Institute (Instituto Nacional de las Personas Adultas Mayores-INAPAM) in Tabasco. Sampling was not used. The selection criteria invol ved elderly adults who were enrolled in INAPAM from January/2004-December/2006. Socio-demographic, sanitary and personal preferences were the variables considered. INAPAM's Mexican Survey of Senior Citizens' database for the study period was used for providing the necessary information; descriptive statistics were used for analysis. Some elderly adults were unable to work (11.9 %); those working did so in the countryside (10.5 %). Almost all of them had some sort of income (99.8 %): family support (46 %) or employment (22.3 %). A fifth of the population were illiterate (21 %). Most of them li ved with someone else (88.9 %) with a spouse (57.3 %) or children (45.9 %). Most li ved in their own houses (87.1 %), had basic services (94.3 %) and a stove, television and refrigerator (74.5 %). The frequently occurring diseases were osteo-degenerative (50.4 %), ophthalmic (39.2 %) dental (16.3 %), high blood pressure-related, Diabetes mellitus and tumours. Most had social security (63.3 %) but mostly used Mexican Ministry of Health services (28.7 %). They fostered the following values: health (81.2 %), family (72.4 %) and love (45.9 %); sharing family time was the most frequent free-time activity (72 %) followed by religious activities (56.4 %). The aforementioned features formed the gerontological profile for elderly adults in Tabasco; and the results of this series partially differed from that reported by other Mexican institutions.

  3. On the electromagnetic fields produced by marine frequency domain controlled sources

    NASA Astrophysics Data System (ADS)

    Chave, Alan D.

    2009-12-01

    In recent years, marine controlled source electromagnetics (CSEM) has found increasing use in hydrocarbon exploration due to its ability to detect thin resistive zones beneath the seafloor. Although it must be recognized that the quantitative interpretation of marine CSEM data over petroleum-bearing formations will typically require 2-D surveys and 2-D or 3-D modelling, the use of the 1-D approximation is useful under some circumstances and provides considerable insight into the physics of marine CSEM. It is the purpose of this paper to thoroughly explore the 1-D solutions for all four fundamental source types-vertical and horizontal, electric and magnetic dipole (VED, HED, VMD and HMD)-using a set of canonical reservoir models that encompass brine to weak to strong hydrocarbon types. The paper introduces the formalism to solve the Maxwell equations for a 1-D structure in terms of independent and unique toroidal and poloidal magnetic modes that circumscribe the salient diffusion physics. Green's functions for the two modes from which solutions for arbitrary source current distributions can be constructed are derived and used to obtain the electromagnetic (EM) fields produced by finite VED, HED, VMD and HMD sources overlying an arbitrary 1-D electrical structure. Field behaviour is analysed using the Poynting vector that represents the time-averaged flow of energy through the structure and a polarization ellipse decomposition of the triaxial seafloor EM field that is a complete field description. The behaviour of the two EM modes using unimodal VED and VMD sources is presented. The paper closes by extending these results to the bimodal HED and HMD sources.

  4. Vestibular nuclei characterized by calcium-binding protein immunoreactivity and tract tracing in Gekko gecko.

    PubMed

    Song, Jing; Wang, Wenbo; Carr, Catherine E; Dai, Zhendong; Tang, Yezhong

    2013-02-01

    Immunohistochemical techniques were used to describe the distribution of the calcium binding proteins calretinin, calbindin and parvalbumin as well as synaptic vesicle protein 2 in the vestibular nuclei of the Tokay gecko (Gekko gecko). In addition, tract tracing was used to investigate connections between the vestibular nerves and brainstem nuclei. Seven vestibular nuclei were recognized: the nuclei cerebellaris lateralis (Cerl), vestibularis dorsolateralis (Vedl), ventrolateralis (Vevl), ventromedialis (Vevm), tangentialis (Vetg), ovalis (VeO) and descendens (Veds). Vestibular fibers entered the brainstem with the ascending branch projecting to Vedl and Cerl, the lateral descending branch to Veds, and the medial descending branch to ipsilateral Vevl. Cerl lay most rostral, in the cerebellar peduncle. Vedl, located rostrally, was ventral to the cerebellar peduncle, and consisted of loosely arranged multipolar and monopolar cells. Vevl was found at the level of the vestibular nerve root and contained conspicuously large cells and medium-sized cells. Veds is a large nucleus, the most rostral portion of which is situated lateral and ventral to Vevl, and occupies much of the dorsal brainstem extending caudally through the medulla. VeO is a spherically shaped cell group lateral to the auditory nucleus magnocellularis and dorsal to the caudal part of Vevl. Vevm and Vetg were small in the present study. Except for VeO, all other vestibular nuclei appear directly comparable to counterparts in other reptiles and birds based on their location, cytoarchitecture, and connections, indicating these are conserved features of the vestibular system. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Possible vasculoprotective role of linagliptin against sodium arsenite-induced vascular endothelial dysfunction.

    PubMed

    Jyoti, Uma; Kansal, Sunil Kumar; Kumar, Puneet; Goyal, Sandeep

    2016-02-01

    Vascular endothelial dysfunction (VED) interrupts the integrity and function of endothelial lining through enhanced markers of oxidative stress and decrease endothelial nitric oxide synthase (eNOS) expression. The main aim of the present study has been designed to investigate the possible vasculoprotective role of linagliptin against sodium arsenite-induced VED. Sodium arsenite (1.5 mg/kg, i.p., 2 weeks) abrogated the acetylcholine-induced, endothelium-dependent vasorelaxation by depicting the decrease in serum nitrite/nitrate concentration, reduced glutathione level, and simultaneously enhance the thiobarbituric acid reactive substances (TBARS) level, superoxide level, and tumor necrosis factor-alpha. These elevated markers interrupt the integrity of endothelial lining of thoracic aorta which was assessed histologically. The study elicits dose dependent effect of linagliptin (1.5 mg/kg, i.p. and 3 mg/kg, i.p.) or atorvastatin (30 mg/kg, p.o.) treatment, improved the endothelium-dependent independent relaxation, improve the integrity of endothelium lining which was assessed histologically by enhancing the serum nitrite/nitrate level, reduced glutathione level and simultaneously decreasing the TBARS level, superoxide anion level and tumor necrosis factor-alpha (TNF-α) level. L-NAME (25 mg/kg, i.p.), eNOS inhibitor, abrogated the ameliorative potential of linagliptin. However, the ameliorative potential of linagliptin has been enhanced by l-arginine (200 mg/kg, i.p.) which elicits that ameliorative potential of linagliptin was through eNOS signaling cascade and it may be concluded that linagliptin 3 mg/kg, i.p. has more significantly activated the eNOS and decreased the oxidative markers than linagliptin 1.5 mg/kg, i.p. and prevented sodium arsenite-induced VED.

  6. Advanced Technology for Improved Quantum Device Properties Using Highly Strained Materials

    DTIC Science & Technology

    1989-06-15

    PREPARED BY: W.J. Schaff S.D. OffseyI DL)L.,C ;.. $T A H. Park At~pio-ved tc- ;p7ua~ic tel-e:a~o L.F. Eastman q uoig4 04 Table of Contents Page...Graded-Index Separate-Confinement Heterostructure Single Quantum Well Lasers Grown by Molecular Beam Epitaxy", S.D. Offsey, W.J. Schaff , P.J. Tasker, H...gle Confinement Single Quantum Well Lasers Grown by Molecular Beam Epitaxy", S.D. Offsey, W.J. Schaff , P.J. Tasker and L.F. Eastman, Device Research

  7. The CCTC Quick-Reacting General War Gaming System (QUICK). Program Maintenance Manual. Volume III. Weapon Allocation Subsystem. Change 2.

    DTIC Science & Technology

    1980-04-30

    A~ O-AOBI a c AND CONTPOL TOIECA L COMi WAIM.DhSO C /me lIs" ATg CCTC SIICKAZACTINS UISRAL AR "MINGSa IVUI SCV PRO-ETC(UI LMASI C L A M Z P II...of Changes. FOR THE DIRECTOR: 129 EnclosuresJ.OG P Change 2 Pages ector . fdor A is ation 7/ z / Tis docitn: is h,,1 Ted. Ved for public rc~cls ; its...BASE PREPARATION VdnPON/TARGET ITIICATIONT SUBSSTM JI2X PLANSET WaEAPON ALLOCATION SUBSYS TEM P’MPALOC ALOC PLAN GEERATION ETALALOC SORTIE GDIURATION

  8. Tidal and Lunar Data for Point Mugu, San Nicholas Island, and the Barking Sands Area during 1989

    DTIC Science & Technology

    1988-12-31

    daylight Autumnal Equinox 22 September 1720 PST Beginning of Autumn Day and night equal length Winter Solstice 21 December 1322 PST Beginning of...DTIC Ne uEC 2 2 1988 V COMPILED BYRICH DIXON GEOPHYSICS DivIsoN 31 DECEMBER 1988 APPRoVED FOR PUBLIC RELEASE; DISTRIBUTION Is UNLIMITED PACIFIC MISSILE...PAGE CO.’ Annual FROM TO 1988, December , 31 41 ., P, J-J TARY NOTATiON COSAT’ CODES 18 SUBJECT T ERMS (Continue on reverse if necessary and identify by

  9. Thermochemistry of Gaseous Compounds of Metals.

    DTIC Science & Technology

    1981-03-01

    Ifl////// EEEI/EEEEEEEEE/I/I/I/EEE//EE EEEEEEEEE//EEI EE/IEI/E//E//E AFOSR.TR. 8 1 -to3 FC March 1981 Final Technical Report 5 December 1977 to 4...ved) TABLE OF CONTENTS ABSTRACT ii Research Objectives 1 Technical Approach 2 Results 3 Professional Personnel 10 Publications 10 REFERENCES 11...8217. ". rA TO DT)C Ti t : ’ 1 ,., t., reviewed and is approv. IA AFR 190-12 (7b). Distri. , : ’, .. : l t d A. D. Biu,. Technical k:,)’orII1t.lon Officer

  10. The Influence of 8 Weeks of Whey-Protein and Leucine Supplementation on Physical and Cognitive Performance

    DTIC Science & Technology

    2010-01-01

    branchecl -chain mino ac ids ( BCAA ) may a lso improve cogni t ive per formance dur ing latigue. Blornstrand, Hassmdn, Eckblorn, and News- holme (1q91...1991) and Hassmdn, Blornstrand, Eck- blom, and Newsholme (1994) observecl that participants supplemented with BCAAs scored better on both mood lcvels...whey and casein, whey and BCAAs . or’ placebo ver’ I 0 weeks of R1’. ’fhey obser"ved a significant incrcase in l-RM BP in all 3 groups with no

  11. Is the daily use of vacuum erection device for a month before penile prosthesis implantation beneficial? a randomized controlled trial.

    PubMed

    Canguven, O; Talib, R A; Campbell, J; De Young, L; El Ansari, W; Al-Ansari, A

    2017-01-01

    Patient concerns about penile length after penile prosthesis (PP) implantation for erectile dysfunction (ED) have significant impact on patients and their partners. In addition, corporal fibrosis is associated with difficult PP implantation. The preoperative use of vacuum erectile devices (VED) is an uncommon physical treatment for such concerns. Therefore, the current randomized controlled study assessed two outcomes: whether pre-operative VED use for a month before surgery would significantly increase flaccid stretched penile length (SPL) on the day of surgery, and facilitate easier corporal dilatation intraoperatively. Fifty-one patients scheduled for PP implantation for ED were randomized to either intervention group (pre-operative VED use; 10-15 min/day for ≥30 days; Group A; n = 25), or control group (no intervention; Group B; n = 26). A research assistant (blinded to the treatment assignments) recorded SPL at baseline (initial consultation) and on day of surgery. The surgeons performing the PP implantation (also blinded to the treatment assignments) provided subjective assessments of the ease of corporal dilatation. Baseline patient characteristics, demographics, and comorbidities were the same in both groups. Baseline measurements (SPL-1) were 10.71 ± 1.28 and 10.87 ± 1.26 cm in Group A and Group B, respectively; and the day of surgery measurements (SPL-2) were 11.50 ± 1.33 and 11.06 ± 1.34 cm in Group A and Group B, respectively. In terms of outcomes: mean SPL increase in Group A was significantly more by a mean of 0.80 ± 0.38 cm (p < 0.05) compared to Group B; and surgeons' subjective report of surgical ease indicated smoother corporal dilatation for Group A compared to Group B. VED use (10-15 min/day during the month prior to PP implantation) was associated with significantly increased SPL on day of surgery, and facilitated easier corporal dilatation intraoperatively. Future studies should examine the long-term outcomes of

  12. Controlled Growth of Parallel Oriented ZnO Nanostructural Arrays on Ga2O3 Nanowires

    DTIC Science & Technology

    2008-11-01

    Controlled Growth of Parallel Oriented ZnO Nanostructural Arrays on Ga2O3 Nanowires Lena Mazeina,* Yoosuf N. Picard, and Sharka M. Prokes Electronics...Manuscript ReceiVed NoVember 6, 2008 ABSTRACT: Novel hierarchical ZnO- Ga2O3 nanostructures were fabricated via a two stage growth process. Nanowires of Ga2O3 ...nanobrushes (NBs) with Ga2O3 as the core and ZnO as the branches self-assembling symmetrically in six equiangular directions around the core

  13. A Systems Engineering Based Methodology for Analyzing Human Electrocortical Responses.

    DTIC Science & Technology

    1987-07-20

    D f Lh modeling provided a promising approach for hiandling obse ved r n the dcita. Model Parameter values were found to relate- tr S ...designed to be similar. Due to the nature of the two 121 FiR 5 5a0 Fig 5 0 0.. .. . . LO ° s .. . " R "R " - " - ,". ’. ’Io rpc ("IM O’CY 1. - g e -lip le e...w d - A’ --- • -A N - 46 .- - Iv e s -a S8ECT 32 -400 -1100 j ’.J - 00 000 - LIGHTS ONLY DECISION EASY DECISION HARD "* - U ".. FP[OUttu Y H

  14. Histogram Equalization with Variable Enhancement Degree for Preserving Mean Brightness

    NASA Astrophysics Data System (ADS)

    Kawakami, Takashi; Murahira, Kota; Taguchi, Akira

    The histogram equalization (HE) is one of the common methods used for improving contrast in digital images. However, this technique causes a fluctuation of mean brightness. The fluctuation leads to the flicker for video signal. In order to preserve the mean brightness, the dynamic histogram equalization (DHE) is proposed. In this letter, we propose a novel DHE which is called the DHE with variable enhancement degree (DHEwVED). This method can change from DHE to HE by turning one parameter. We also show the effectiveness of the proposed method.

  15. Duwamish Waterways Navigation Improvement Study: Review of Existing Information on Land-Use Plans and Aquatic Resources in and Adjacent to the Duwamish River and Elliott Bay, Washington

    DTIC Science & Technology

    1980-06-01

    STATEMENT A Apr,’.,ved for public rel*o,4 Distribution Unlimited TABLE OF CONTENTS Page INTRODUCTION ii A, LAND USE A-i to A-89 Summary A-2 Information...Sources A-3 1 Plans, Policies, and Related Documents A-4 Surveys and Inventories A-36 Environmental and Archaeological Assessments A-47 Other A-69 B...general with r.espect to content and location or provid& only a limited examination of pre-existinq data. Articles were abstracted or the author’s

  16. Visual Electricity Demonstrator

    NASA Astrophysics Data System (ADS)

    Lincoln, James

    2017-09-01

    The Visual Electricity Demonstrator (VED) is a linear diode array that serves as a dynamic alternative to an ammeter. A string of 48 red light-emitting diodes (LEDs) blink one after another to create the illusion of a moving current. Having the current represented visually builds an intuitive and qualitative understanding about what is happening in a circuit. In this article, I describe several activities for this device and explain how using this technology in the classroom can enhance the understanding and appreciation of physics.

  17. A Four-Phase Modulation System for Use with an Adaptive Array.

    DTIC Science & Technology

    1982-07-01

    channel, the signal-to- noise ratio out of the filter is given by P. PSS/ NIIF N B . (183) The signal-to-noise ratio in the ith channel for any timing off...set is then given by P5s S/N I = S/ NIIF P S (184) The output of the linear envelope detector is described by its mean and power spectral density. To...228) 11 p These values are independent of other parameters invol ved (such as S/ NIIF ) to the accuracy shown here. Note that Equation (227

  18. Mathematical Studies of Wavelet Inverse Reconstructions for Nondestructive Evaluation, Novel Dielectrics, and the Dispersion from Chaotic Motions in Water

    DTIC Science & Technology

    2007-11-02

    dispersion of water from a previous AFOSR grant. The wavelet studies were direct^ toward nondestructive evaluation using ultrasonic waves. The...novel dielectrics were mainly the PBGS, photonic band gap structures - periodic arrays of a dielectric with permitivity »^ embedded in a...n g au9lan°S irtHeXCePti1° nal "^ "^ *™^" °™«" much 0? Z Tnilf TeUt phaSe Space- This metn°° ^ved mucn of the noise from the

  19. Pathfinder. Volume 9, Number 1, January/February 2011

    DTIC Science & Technology

    2011-02-01

    Intelligence Agency team member Ken Brewer rece ved the Department of Defense Outstanding Employee with a Disability award Dec. 7 in Bethesda, Md...Personnel and Readiness, joined NGA Director Letitia A. Long in recognizing Brewer with this honor and presenting him with the award. “I am honored...to be named as one of the DOD’s Outstanding Employees with a Disability,” Brewer said. “This is an unforgettable moment in my life.” The award

  20. An Introduction to the Literature of Search Theory

    DTIC Science & Technology

    1981-06-01

    continuous space. His objective was to optimize allo- cation of search effort. Suppose that we have a search area divided into two parts A1 and A2 1...7 p,., Atop 110, Nasleda, Miesasir K., "Labot Supply of Whenr with AD Ans 212 pp Rol Husbiand StinploVed Either Pull Thme Or Part Vile, Wkso L...pp,. Hov ¶524 (DI~ehNred us the ltisenethonall Mgrrehi, Maurice, "A Targeting Problein Segars Theflory coulsleiso integrale Using Usea Geserllead

  1. Flying Qualities of Relaxed Static Stability Aircraft. Volume 2. Ramifications of Flight-Essential/Critical Heavily-Augmented Airplane Characteristics on Flying Qualities

    DTIC Science & Technology

    1982-09-01

    root variation am is perwltte4 to becout sort uaatlvs ( eeg ., cog. Wereeeixuly w~ved further fotowrd of the neutral potat). % w~a e t-period dh~a~a fs Cc...deg-sec) unit impulse. For sueh an input the pit~ch att.It~ tdc responses in !A’gure 11 appear with the same response shapes as those deacribed...this pair approaches the clewaical tm -degree-of-froedo. phugoid mode dwereint Z’ V/gZuAT &rglo I n this classic phugoid (Ref erence 22) the angle of

  2. Modeling of a viscoelastic damper and its application in structural control

    PubMed Central

    Ibrahim, Zainah; Ghodsi, S. S.; Khatibi, Hamed

    2017-01-01

    Conventional seismic rehabilitation methods may not be suitable for some buildings owing to their high cost and time-consuming foundation work. In recent years, viscoelastic dampers (VEDs) have been widely used in many mid- and high-rise buildings. This study introduces a viscoelastic passive control system called rotary rubber braced damper (RRBD). The RRBD is an economical, lightweight, and easy-to-assemble device. A finite element model considering nonlinearity, large deformation, and material damage is developed to conduct a parametric study on different damper sizes under pushover cyclic loading. The fundamental characteristics of this VED system are clarified by analyzing building structures under cyclic loading. The result show excellent energy absorption and stable hysteresis loops in all specimens. Additionally, by using a sinusoidal shaking table test, the effectiveness of the RRBD to manage the response displacement and acceleration of steel frames is considered. The RRBD functioned at early stages of lateral displacement, indicating that the system is effective for all levels of vibration. Moreover, the proposed damper shows significantly better performance in terms of the column compression force resulting from the brace action compared to chevron bracing (CB). PMID:28570657

  3. Development of a novel overmoded sub-terahertz inclined coaxial clinotron with asymmetric mode suppressed

    NASA Astrophysics Data System (ADS)

    Chen, Zaigao; Wang, Yue

    2017-10-01

    Overmoded coaxial high frequency structures can improve the power capacity of vacuum electron devices (VEDs) and make the fabrication and assembly of the devices easy in the terahertz band, but they also lead to mode competition and deleterious effect on the beam-wave interaction. The numerical investigation on the cold cavity characteristics indicates that the dispersion curve of the quasi-TEM mode almost overlaps with the dispersion curve of the high-order quasi-TE11 mode, and the 3-D numerical simulation results also illustrate that due to the mode competition, the quasi-TEM cannot be excited steadily in the VEDs with traditional coaxial SWSs with the available current density. In order to effectively suppress the mode competition of overmoded coaxial SWSs, novel inclined coaxial slow wave structures (SWSs) are proposed in this paper. As the overmoded ratio of the SWSs reaches 9.7, the 3D particle-in-cell simulation results indicate that this novel device can successfully produce the terahertz wave with the output power of 571 W at the operating frequency of 0.338 THz, and the frequency spectrum of the generated signal is very pure. The field distributions in the inclined coaxial SWSs illustrate that there is no asymmetric mode excited in the proposed device.

  4. Assessment of Ganga river ecosystem at Haridwar, Uttarakhand, India with reference to water quality indices

    NASA Astrophysics Data System (ADS)

    Bhutiani, R.; Khanna, D. R.; Kulkarni, Dipali Bhaskar; Ruhela, Mukesh

    2016-06-01

    The river Ganges is regarded as one of the most holy and sacred rivers of the world from time immemorial. The evaluation of river water quality is a critical element in the assessment of water resources. The quality/potability of water that is consumed defines the base line of protection against many diseases and infections. The present study aimed to calculate Water Quality Index (WQI) by the analysis of sixteen physico-chemical parameters on the basis of River Ganga index of Ved Prakash, weighted arithmetic index and WQI by National sanitation foundation (NSF) to assess the suitability of water for drinking, irrigation purposes and other human uses. These three water quality indices have been used to assess variation in the quality of the River Ganga at monitored locations over an 11-year period. Application of three different indexes to assess the water quality over a period of 11 years shows minor variations in water quality. Index values as per River Ganga Index by Ved Prakash et al. from 2000 to 2010 ranged between medium to good, Index values as per NSF Index for years 2000-2010 indicate good water quality, while Index values as per the weighted arithmetic index method for the study period indicate poor water quality.

  5. [The Contribution of Vascular Capacity and Blood Volume to Maintain Stable Blood Circulation during General Anesthesia].

    PubMed

    Shigemi, Kenji

    2016-05-01

    To maintain proper cardiac preload is one of the most effective procedures for the systemic circulation remaining stable. In particular, the balance between vascular capacity and total blood volume must be maintained within appropriate range by the administration of fluids, blood and/or vasoactive drugs with mean circulatory filling pressure (Pmcf), central venous pressure (CVP) or stroke volume variation (SVV). End-diastolic left ventricular volume (Ved) is theoretically the best index of cardiac preload; however, without transesophageal echocardbalanceiogram we cannot directly monitor Ved during anesthesia. The infused fluid volume remaining in intravascular space, the vascular capacity controlled by autonomic nervous system and/or vasoactive agents, and the unstressed blood volume properly mobilized to excess blood volume are the crucial factors to maintain cardiac output The knowledge of vascular physiology contribute the decision making to manipulate such factors to control blood circulation during general anesthesia. For example, CVP is usually maintained in the narrow range and seems to be stable; however, it must be changed just after the circulatory disturbances, such as acute bleeding, blood transfusion, and fluid infusion, and followed by gradual returning to initial value, because of the solid mechanism to preserve cardiac output

  6. Generalization of geometrical flux maximizing flow on Riemannian manifolds for improved volumetric blood vessel segmentation.

    PubMed

    Gooya, Ali; Liao, Hongen; Sakuma, Ichiro

    2012-09-01

    Geometric flux maximizing flow (FLUX) is an active contour based method which evolves an initial surface to maximize the flux of a vector field on the surface. For blood vessel segmentation, the vector field is defined as the vectors specified by vascular edge strengths and orientations. Hence, the segmentation performance depends on the quality of the detected edge vector field. In this paper, we propose a new method for level set based segmentation of blood vessels by generalizing the FLUX on a Riemannian manifold (R-FLUX). We consider a 3D scalar image I(x) as a manifold embedded in the 4D space (x, I(x)) and compute the image metric by pullback from the 4D space, whose metric tensor depends on the vessel enhancing diffusion (VED) tensor. This allows us to devise a non-linear filter which both projects and normalizes the original image gradient vectors under the inverse of local VED tensors. The filtered gradient vectors pertaining to the vessels are less sensitive to the local image contrast and more coherent with the local vessel orientation. The method has been applied to both synthetic and real TOF MRA data sets. Comparisons are made with the FLUX and vesselsness response based segmentations, indicating that the R-FLUX outperforms both methods in terms of leakage minimization and thiner vessel delineation.

  7. An aerostat-supported ELF/VLF transmitter

    NASA Astrophysics Data System (ADS)

    Field, E. C., Jr.; Kies, L. R.; Bannister, P. R.; Ingram, R. F.; Hopkins, W. D.; Roberts, M. A.

    1989-03-01

    A demonstration of an aerostat-supported extremely low frequency/very low frequency (ELF/VLF) transmitting antenna was performed. At ELF the vertical electric dipole (VED) antenna radiated at least 100,000 times more power than would a horizontal electric dipole having the same moment. That efficiency was achieved with an altitude of 12,500 feet (3810 m). Calculations show that the radiated power will increase as the fourth power of aerostat altitude. The tether antenna exhibited a corona onset voltage of 180 kV and was resistant to the degrading effects of ELF corona. Prolonged in-corona operation is therefore possible. The antenna was continuously tuned, despite changes in height and capacitance caused by the aerostat flight dynamics. The huge 300-H ELF tuning inductor posed no problem. Enhanced VED moments were achieved at ELF by operation at voltages up to 260 kV, 40% above the corona onset voltage. At VLF the antenna emulated a monopole that had a radiation efficiency greater than 90%. The measured bandwidths were large: 1.5 kHz at 23 kHz and 3.5 kHz at 34 kHz. The antenna height exceeded one-quarter wavelength at VLF, so the antenna could be tuned capacitively and required relatively low base voltages. At both VLF and ELF the measured fields agreed closely with predictions.

  8. Medical Store Management: An Integrated Economic Analysis of a Tertiary Care Hospital in Central India

    PubMed Central

    Mahatme, MS; Dakhale, GN; Hiware, SK; Shinde, AT; Salve, AM

    2012-01-01

    Economic analysis plays a pivotal role in the management of medical store. The main objectives of this study were to consider always better control-vital, essential and desirable (ABC-VED) analysis with economic order quantity (EOQ), comparison of indexed cost and the actual cost, and to assess the expenditure for the forthcoming years. Based on cost and criticality, a matrix of nine groups by combining ABC and VED analysis was formulated. Drug categories were narrowed down for prioritization to direct supervisory monitoring. The subgroups AE and AV of the categories category I and II should be ordered based on EOQ. The difference between the actual annual drug expenditure (ADE) and the derived indexed cost using the cost inflation index (CII) was calculated. Linear regression was used to assess the expenditure for the forth coming years. The total ADE for the financial year of 2010–2011 was Rs. 1,91,44,253 which was only 7.68% of annual hospital expenditure. Using the inflation index, the indexed cost of acquisition of ADE for year 2010–2011 was Rs. 1,95,10,387. The difference between the two was estimated to be 2.11%. Thus, the CII justifies the demand of increased budget for next year and prompts us for cautious use of drugs. By taking into consideration the ADE of last 10 years, we have forecasted the budget for forthcoming years which will help significantly for making policies according to the available budget. PMID:22754264

  9. Design of Visco-Elastic Dampers for RC Frame for Site-Specific Earthquake

    NASA Astrophysics Data System (ADS)

    Kamatchi, P.; Rama Raju, K.; Ravisankar, K.; Iyer, Nagesh R.

    2016-12-01

    Number of Reinforced Concrete (RC) framed buildings have got damaged at Ahmedabad city, India located at about 240 km away from epicenter during January 2001, 7.6 moment magnitude (Mw) Bhuj earthquake. In the present study, two dimensional nonlinear time history dynamic analyses of a typical 13 storey frame assumed to be located at Ahmedabad is carried out with the rock level and surface level site-specific ground motion for scenario earthquake of Mw 7.6 from Bhuj. Artificial ground motions are generated using extended finite source stochastic model with seismological parameters reported in literature for 2001 Bhuj earthquake. Surface level ground motions are obtained for a typical soil profile of 100 m depth reported in literature through one dimensional equivalent linear wave propagation analyses. From the analyses, failure of frame is observed for surface level ground motions which indicates that, in addition to the in-adequacy of the cross sections and reinforcement of the RC members of the frame chosen, the rich energy content of the surface level ground motion near the fundamental time period of the frame has also contributed for the failure of frame. As a part of retrofitting measure, five Visco-elastic Dampers (VED) in chevron bracing are added to frame. For the frame considered in the present study, provision of VED is found to be effective to mitigate damage for the soil site considered.

  10. Comparison of vessel enhancement algorithms applied to Time-of-Flight MRA images for cerebrovascular segmentation.

    PubMed

    Phellan, Renzo; Forkert, Nils D

    2017-09-07

    Vessel enhancement algorithms are often used as a preprocessing step for vessel segmentation in medical images to improve the overall segmentation accuracy. Each algorithm uses different characteristics to enhance vessels, such that the most suitable algorithm may vary for different applications. This paper presents a comparative analysis of the accuracy gains in vessel segmentation generated by the use of nine vessel enhancement algorithms: Multiscale vesselness using the formulas described by Erdt (MSE), Frangi (MSF), and Sato (MSS), optimally oriented ux (OOF), ranking orientations responses path operator (RORPO), the regularized Perona-Malik approach (RPM), vessel enhanced diffusion (VED), hybrid diffusion with continuous switch (HDCS), and the white top hat algorithm (WTH). The filters were evaluated and compared based on time-of-flight MRA datasets and corresponding manual segmentations from _ve healthy subjects and ten patients with an arteriovenous malformation. Additionally, five synthetic angiographic datasets with corresponding ground truth segmentation were generated with three different noise levels (low, medium, high) and also used for comparison. The parameters for each algorithm and subsequent segmentation were optimized using leave-one-out cross evaluation. The Dice coefficient, Matthews correlation coefficient, area under the ROC curve, number of connected components, and true positives were used for comparison. The results of this study suggest that vessel enhancement algorithms do not always lead to more accurate segmentation results compared to segmenting non-enhanced images directly. Multiscale vesselness algorithms, such as MSE, MSF, and MSS proved to be robust to noise, while diffusion-based filters, such as RPM, VED, and HDCS ranked in the top of the list in scenarios with medium or no noise. Filters that assume tubular-shapes, such as MSE, MSF, MSS, OOF, RORPO, and VED show a decrease in accuracy when considering patients with an AVM

  11. Extending color primary set in spectral vector error diffusion by multilevel halftoning

    NASA Astrophysics Data System (ADS)

    Norberg, Ole; Nyström, Daniel

    2013-02-01

    Ever since its origin in the late 19th century, a color reproduction technology has relied on a trichromatic color reproduction approach. This has been a very successful method and also fundamental for the development of color reproduction devices. Trichromatic color reproduction is sufficient to approximate the range of colors perceived by the human visual system. However, tricromatic systems only have the ability to match colors when the viewing illumination for the reproduction matches that of the original. Furthermore, the advancement of digital printing technology has introduced printing systems with additional color channels. These additional color channels are used to extend the tonal range capabilities in light and dark regions and to increase color gamut. By an alternative approach the addition color channels can also be used to reproduce the spectral information of the original color. A reproduced spectral match will always correspond to original independent of lighting situation. On the other hand, spectral color reproductions also introduce a more complex color processing by spectral color transfer functions and spectral gamut mapping algorithms. In that perspective, spectral vector error diffusion (sVED) look like a tempting approach with a simple workflow where the inverse color transfer function and halftoning is performed simultaneously in one single operation. Essential for the sVED method are the available color primaries, created by mixing process colors. Increased numbers of as well as optimal spectral characteristics of color primaries are expected to significantly improve the color accuracy of the spectral reproduction. In this study, sVED in combination with multilevel halftoning has been applied on a ten channel inkjet system. The print resolution has been reduced and the underlying physical high resolution of the printer has been used to mix additional primaries. With ten ink channels and halfton cells built-up by 2x2 micro dots where each

  12. Identification of GI cancers utilising rapid mid-infrared spectral imaging

    NASA Astrophysics Data System (ADS)

    Nallala, Jayakrupakar; Lloyd, Gavin R.; Kendall, Catherine; Barr, Hugh; Shepherd, Neil; Stone, Nick

    2016-03-01

    Pathologists find it notoriously difficult to provide both inter- and intra-observer agreement on a diagnosis of early gastrointestinal cancers. Vibrational spectroscopic approaches have shown their value in providing molecular compositional data from tissue samples and therefore enabling the identification of disease specific changes, when combined with multivariate techniques. Mid-infrared microscopic imaging is undergoing rapid developments in sources, detectors and spectrometers. Here we explore the use of high magnification FTIR for GI cancers and consider how the MINERVA (MId- to NEaR infrared spectroscopy for improVed medical diAgnostics) project, which is developing discrete frequency IR imaging tools will enable histopathologists to obtain rapid molecular images form unstained tissue sections.

  13. Electron Spectroscopy Data for the High-Temperature Superconductors. What can We Learn from it?

    DTIC Science & Technology

    1988-12-01

    and Qp. We also include the inter-site repulsion energies Uap and Up,* (i.e. between neighboring Cu-0 and 0-0 atoms). An important parameter is the...TABLE I (cont.) Stateb Energy expression Calc. E. Exp. E. Remark eVed eV€ Cu LsNtsY ARS, cvl cdp cc+c,+Qd+ Uap ;K+a ce +9 ZjpVlO main,’L ce+17 E3,+18 main...B. at al. PhZ_..!Rpv. 1987, B35, 8804. 28. Klopman, G. J. Am. Chem. Soc. 1964 , 86, 4550. 29. Brower J.S. at al. Phys. Rev. Lett. 1988, 60, 1073. 30

  14. The treatment of erectile dysfunction in patients with neurogenic disease

    PubMed Central

    Brant, William O.

    2016-01-01

    Erectile dysfunction (ED) related to compromise of the nervous system is an increasingly common occurrence. This may be due to the multifactorial nature of ED, the myriad of disorders affecting the neurotransmission of erectogenic signals, and improved awareness and diagnosis of ED. Nevertheless, neurogenic ED remains poorly understood and characterized. Disease related factors such as depression, decreased physical and mental function, the burden of chronic illness, and loss of independence may preclude sexual intimacy and lead to ED as well. The amount of data regarding treatment options in subpopulations of differing neurologic disorders remains scarce except for men with spinal cord injury. The treatment options including phosphodiesterase inhibitors, intracavernosal or intraurethral vasoactive agents, vacuum erection devices (VED) and penile prosthetic implantation remain constant. This review discusses the options in specific neurologic conditions, and briefly provides insight into new and future developments that may reshape the management of neurogenic ED. PMID:26904415

  15. A Low Cost Traveling Wave Tube for Wireless Communications

    NASA Technical Reports Server (NTRS)

    Vancil, Bernard Kenneth; Wintucky, Edwin G.; Williams, W. D. (Technical Monitor)

    2002-01-01

    Demand for high data rate wireless communications is pushing up amplifier power, bandwidth and frequency requirements. Some systems are using vacuum electron devices again because solid-state power amplifiers are not able to efficiently meet the new requirements. The traveling wave tube is the VED of choice because of its excellent broadband capability as well as high power efficiency and frequency. But TWTs are very expensive on a per watt basis below about 200 watts of output power. We propose a new traveling wave tube that utilizes cathode ray tube construction technology and electrostatic focusing. We believe the tube can be built in quantity for under $1,000 each. We discuss several traveling wave tube slow wave circuits that lend themselves to the new construction. We will present modeling results and data on prototype devices.

  16. An evaluation of the accuracy of some radar wind profiling techniques

    NASA Technical Reports Server (NTRS)

    Koscielny, A. J.; Doviak, R. J.

    1983-01-01

    Major advances in Doppler radar measurement in optically clear air have made it feasible to monitor radial velocities in the troposphere and lower stratosphere. For most applications the three dimensional wind vector is monitored rather than the radial velocity. Measurement of the wind vector with a single radar can be made assuming a spatially linear, time invariant wind field. The components and derivatives of the wind are estimated by the parameters of a linear regression of the radial velocities on functions of their spatial locations. The accuracy of the wind measurement thus depends on the locations of the radial velocities. The suitability is evaluated of some of the common retrieval techniques for simultaneous measurement of both the vertical and horizontal wind components. The techniques considered for study are fixed beam, azimuthal scanning (VAD) and elevation scanning (VED).

  17. Laser Structures for Projectional Television and Other Applications

    DTIC Science & Technology

    1980-07-29

    crystal makes it more difc-24t to rem ove, the heet forited in the Oenaration. area. The theoretical, ef fcien~y q-? lasers excitVed by an electr.on...vari’ c.s drawbacks in the o f)erat io n o-i the Apparatus, and Makes it n ecess~ary to- uise, zrotecti-6p. agaihst ay radatin’On the oth~r habd...hydro- ehi PiOr. 3. Diagram 0-6f the- vave-c6hIduciz g laser- stuctuJ’.e-, The layers- forped had a thic’krness of-: 2O-1lam. ’~elayers had uneven surfaces

  18. Feasibility Study of Improved Methods for Riverbank Stabilization

    DTIC Science & Technology

    1964-11-01

    stabilization, that of sun drying, has been used for many cen- turies in making adobe . However, the hardening which o ccu1· s during this process is...lbwn • ••lty 0. tl4-0 "* ’ · otf.J, .)to ..... ,oo t O UO ... I r -o ... . ,. l lo:•t Stl 0 1’ •• hiCh d-~Uiy 0 t41·0.M-\\ 1, •oo. r., HIO )! • SOl > 10...This does not include an~r ballast to keep the mattress in place. The problem of impermeability is one that could be sol ved by mak- ing more

  19. Vascular Ehlers-Danlos syndrome: a rare disorder presenting with focal convulsions.

    PubMed

    Ahmed, Shakeel; Ali, Syed Rehan; Nadeem, Naila; Hamid, Muhammad

    2014-11-01

    Vascular Ehlers-Danlos Syndrome (VEDS), previously called Ehlers-Danlos syndrome type-IV, is a heterogeneous group of heritable connective tissue disorders characterized by thin, translucent skin, easy bruising, arterial, intestinal, and/or uterine fragility. There is large vessel involvement that leads to arterial rupture often preceded by aneurysm, arteriovenous fistulae, or dissection. Noninvasive imaging studies such as CT angiography and MR angiography are preferred as diagnostic studies for this condition. We are reporting a 4 years old girl who was presented with right sided unilateral convulsions and hypertension. CT angiogram showed stenosis with post-stenotic dilatation of coeliac and superior mesenteric arteries. There were extensive calcified plaques with atherosclerotic changes in the segment of right common iliac artery with aneurysmal dilatation of celiac, superior mesenteric and common iliac artery. Radiological findings were consistent with vascular Ehlers-Danlos syndrome. She was successfully managed with anti-hypertensive and anticonvulsants.

  20. Axisymmetric charge-conservative electromagnetic particle simulation algorithm on unstructured grids: Application to microwave vacuum electronic devices

    NASA Astrophysics Data System (ADS)

    Na, Dong-Yeop; Omelchenko, Yuri A.; Moon, Haksu; Borges, Ben-Hur V.; Teixeira, Fernando L.

    2017-10-01

    We present a charge-conservative electromagnetic particle-in-cell (EM-PIC) algorithm optimized for the analysis of vacuum electronic devices (VEDs) with cylindrical symmetry (axisymmetry). We exploit the axisymmetry present in the device geometry, fields, and sources to reduce the dimensionality of the problem from 3D to 2D. Further, we employ 'transformation optics' principles to map the original problem in polar coordinates with metric tensor diag (1 ,ρ2 , 1) to an equivalent problem on a Cartesian metric tensor diag (1 , 1 , 1) with an effective (artificial) inhomogeneous medium introduced. The resulting problem in the meridian (ρz) plane is discretized using an unstructured 2D mesh considering TEϕ-polarized fields. Electromagnetic field and source (node-based charges and edge-based currents) variables are expressed as differential forms of various degrees, and discretized using Whitney forms. Using leapfrog time integration, we obtain a mixed E - B finite-element time-domain scheme for the full-discrete Maxwell's equations. We achieve a local and explicit time update for the field equations by employing the sparse approximate inverse (SPAI) algorithm. Interpolating field values to particles' positions for solving Newton-Lorentz equations of motion is also done via Whitney forms. Particles are advanced using the Boris algorithm with relativistic correction. A recently introduced charge-conserving scatter scheme tailored for 2D unstructured grids is used in the scatter step. The algorithm is validated considering cylindrical cavity and space-charge-limited cylindrical diode problems. We use the algorithm to investigate the physical performance of VEDs designed to harness particle bunching effects arising from the coherent (resonance) Cerenkov electron beam interactions within micro-machined slow wave structures.

  1. Effects of transanal pelvic plexus stimulation on penile erection: clinical implications.

    PubMed

    Kayigil, Onder; Agras, Koray; Gurdal, Mesut; Serefoglu, Ege Can; Okulu, Emrah; Ucgul, Yusuf

    2007-01-01

    To determine the ability of transanal pelvic plexus stimulation (TPPS) in inducing penile tumescence in patients with non-neurogenic erectile dysfunction (ED) and to compare the erection degree with papaverine-induced erection. The cavernous electrical activity (CEA) in 21 men with non-neurogenic erectile dysfunction was measured during TPPS by electromyography of corpus cavernosum and the erection degree of penis (flaccid, semi-rigid, rigid) was noted. The stimulation amplitude was increased from 20 to 100 mA. All patients also underwent intracavernous papaverine injection and further CEA recordings were obtained. Twelve and nine patients were diagnosed with vasculogenic (VED) and non-vasculogenic ED (NVED), respectively. TPSS led to a penile erectile response in 12 patients (57%), whereas papaverine injection caused erection in 16 (76.2%) patients. The mean baseline CEA (16.9 +/- 9.1 mV) did not change with TPPS, but papaverine significantly decreased the mean CEA to 12.3 +/- 4.9 mV (P < 0.001). CEA recordings of 16 (76.2%) patients revealed a significant decrease after papaverine injection, however seven (33.3%) patients showed significant CEA decrease in response to TPPS. Both TPPS and papaverine were observed to have a higher effect in patients with NVED in terms of inducing penile erection and decreasing CEA compared to their effects in patients with VED. TPPS induces penile erection and decreases CEA for some extent, but to a lesser degree compared to papaverine. As further improvements are achieved in the methodology of TPPS, it may be a valuable method in the evaluation patients with erectile dysfunction.

  2. Coronary MR angiography using citrate-coated very small superparamagnetic iron oxide particles as blood-pool contrast agent: initial experience in humans.

    PubMed

    Wagner, Moritz; Wagner, Susanne; Schnorr, Jörg; Schellenberger, Eyk; Kivelitz, Dietmar; Krug, Lasse; Dewey, Marc; Laule, Michael; Hamm, Bernd; Taupitz, Matthias

    2011-10-01

    To evaluate very small superparamagnetic iron oxide particles (VSOP-C184) as blood-pool contrast agent for coronary MR angiography (CMRA) in humans. Six healthy volunteers and 14 patients with suspected coronary artery disease underwent CMRA after administration of VSOP-C184 at the following doses: 20 μmol Fe/kg (4 patients), 40 μmol Fe/kg (5 patients), 45 μmol Fe/kg (6 healthy volunteers), and 60 μmol Fe/kg (5 patients). In healthy volunteers, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and vessel edge definition (VED) of contrast-enhanced CMRA were compared with non-contrast-enhanced CMRA. In patients, a per-segment intention-to-diagnose evaluation of contrast-enhanced CMRA for detection of significant coronary stenosis (≥50%) was performed. Three healthy volunteers (45 μmol Fe/kg VSOP-C184) and two patients (60 μmol Fe/kg VSOP-C184) had adverse events of mild or moderate intensity. VSOP-C184 significantly increased CNR (15.1 ± 4.6 versus 6.9 ± 1.9; P = 0.010), SNR (21.7 ± 5.3 versus 15.4 ± 1.6; P = 0.048), and VED (2.3 ± 0.6 versus 1.2 ± 0.2; P < 0.001) compared with non-contrast-enhanced CMRA. In patients, contrast-enhanced CMRA yielded sensitivity, specificity, and diagnostic accuracy for detection of significant coronary stenosis of 86.7%, 71.0%, 73.1%, respectively. CMRA using VSOP-C184 was feasible and yielded moderate diagnostic accuracy for detection of significant coronary stenosis within this proof-of-concept setting. Copyright © 2011 Wiley-Liss, Inc.

  3. Catechin averts experimental diabetes mellitus-induced vascular endothelial structural and functional abnormalities.

    PubMed

    Bhardwaj, Pooja; Khanna, Deepa; Balakumar, Pitchai

    2014-03-01

    Diabetes mellitus is associated with an induction of vascular endothelial dysfunction (VED), an initial event that could lead to the pathogenesis of atherosclerosis and hypertension. Previous studies showed that catechin, a key component of green tea, possesses vascular beneficial effects. We investigated the effect of catechin hydrate in diabetes mellitus-induced experimental vascular endothelial abnormalities (VEA). Streptozotocin (50 mg/kg, i.p., once) administration to rats produced diabetes mellitus, which subsequently induced VEA in 8 weeks by markedly attenuating acetylcholine-induced endothelium-dependent relaxation in the isolated aortic ring preparation, decreasing aortic and serum nitrite/nitrate concentrations and impairing aortic endothelial integrity. These abnormalities in diabetic rats were accompanied with elevated aortic superoxide anion generation and serum lipid peroxidation in addition to hyperglycemia. Catechin hydrate treatment (50 mg/kg/day p.o., 3 weeks) markedly prevented diabetes mellitus-induced VEA and vascular oxidative stress. Intriguingly, in vitro incubation of L-NAME (100 μM), an inhibitor of nitric oxide synthase, or Wortmannin (100 nM), a selective inhibitor of phosphatidylinositol 3-kinase (PI3K), markedly prevented catechin hydrate-induced improvement in acetylcholine-provoked endothelium-dependent relaxation in the diabetic rat aorta. Moreover, catechin hydrate treatment considerably reduced the elevated level of serum glucose in diabetic rats. In conclusion, catechin hydrate treatment prevents diabetes mellitus-induced VED through the activation of endothelial PI3K signal and subsequent activation of eNOS and generation of nitric oxide. In addition, reduction in high glucose, vascular oxidative stress, and lipid peroxidation might additionally contribute to catechin hydrate-associated prevention of diabetic VEA.

  4. Eukaliuric diuresis and natriuresis in response to the KATP channel blocker U37883A: micropuncture studies on the tubular site of action.

    PubMed

    Huang, D Y; Osswald, H; Vallon, V

    1999-08-01

    1. Systemic application of U37883A, a blocker of ATP sensitive potassium (KATP) channels, elicits diuresis and natriuresis without significantly altering urinary potassium excretion. 2. To elucidate tubular sites of action upstream to the distal nephron, micropuncture experiments were performed in nephrons with superficial glomeruli of anaesthetized Munich-Wistar-Frömter rats during systemic application of U37883A (1, 5 or 15 mg kg-1 i.v.). 3. The observed eukaliuric diuresis and natriuresis in response to U37883A at 15 mg kg-1 was accompanied by an increase in early distal tubular flow rate (VED) from 10 - 18 nl min(-1) reflecting a reduction in fractional reabsorption of fluid up to this site (FR-fluid) of 13%. The latter proposed an effect on water-permeable segments such as the proximal tubule which could fully account for the observed reduction in fractional reabsorption of Na+ up to the early distal tubule (FR-Na+) of 8% and the increase in early distal tubular Na+ concentration ([Na+]ED) from 35 - 51 mM whereas [K+]ED was left unaltered. 4. In comparison, furosemide (3 mg kg-1 i.v.), which acts in the water-impermeable thick ascending limb, elicited diuresis, natriuresis and kaliuresis which were associated with a fall in FR-Na+ of 10% with no change in FR-fluid, and a rise in [Na+]ED from 42 - 117 mM and [K+]ED from 1.2 - 5.7 mM with no change in VED. 5. Direct late proximal tubular fluid collections confirmed a significant inhibition of fluid reabsorption in proximal convoluted tubule in response to systemic application of U37883A. 6. These findings suggest that the diuretic and natriuretic effect upstream to the distal tubule in response to systemic application of U37883A involves actions on water-permeable segments such as the proximal convoluted tubule.

  5. The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome.

    PubMed

    Frank, Michael; Albuisson, Juliette; Ranque, Brigitte; Golmard, Lisa; Mazzella, Jean-Michael; Bal-Theoleyre, Laurence; Fauret, Anne-Laure; Mirault, Tristan; Denarié, Nicolas; Mousseaux, Elie; Boutouyrie, Pierre; Fiessinger, Jean-Noël; Emmerich, Joseph; Messas, Emmanuel; Jeunemaitre, Xavier

    2015-12-01

    Vascular Ehlers-Danlos syndrome (vEDS) is a rare and severe autosomal dominant disorder caused by variants at the COL3A1 gene. Clinical characteristics and course of disease of 215 molecularly proven patients (146 index cases and 69 relatives) were analysed. We found 126 distincts variants that were divided into five groups: (1) Glycine substitutions (n=71), (2) splice-site and in-frame insertions-deletions (n=36), (3) variants leading to haplo-insufficiency (n=7), (4) non-glycine missense variants within the triple helix (n=4 variants), and (5) non-glycine missense variants or in-frame insertions-deletions, in the N- or C-terminal part of the protein (n=8). Overall, our cohort confirmed the severity of the disease with a median age at first complication of 29 years (IQR 22-39), the most frequent being arterial (48%) and digestive (24%) ruptures. Groups 2 and 1 were significantly more severe than groups 3-5, with extreme median ages at first major complication of 23-47 years. Patients of groups 3-5 had a less typical phenotype and remarkably absence of digestive events. The distribution of glycine-replacing amino acids was strongly biased towards more destabilizing residues of the collagen assembly. Thus the natural course of vEDS and the clinical phenotype of patients are influenced by the type of COL3A1 variant. This study also confirms that patients with variants located in the C- and N-termini or leading to haplo-insufficiency have milder course of the disease and less prevalent diagnostic criteria. These findings may help refine diagnostic strategy, genetic counselling and clinical care.

  6. The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers–Danlos syndrome

    PubMed Central

    Frank, Michael; Albuisson, Juliette; Ranque, Brigitte; Golmard, Lisa; Mazzella, Jean-Michael; Bal-Theoleyre, Laurence; Fauret, Anne-Laure; Mirault, Tristan; Denarié, Nicolas; Mousseaux, Elie; Boutouyrie, Pierre; Fiessinger, Jean-Noël; Emmerich, Joseph; Messas, Emmanuel; Jeunemaitre, Xavier

    2015-01-01

    Vascular Ehlers–Danlos syndrome (vEDS) is a rare and severe autosomal dominant disorder caused by variants at the COL3A1 gene. Clinical characteristics and course of disease of 215 molecularly proven patients (146 index cases and 69 relatives) were analysed. We found 126 distincts variants that were divided into five groups: (1) Glycine substitutions (n=71), (2) splice-site and in-frame insertions–deletions (n=36), (3) variants leading to haplo-insufficiency (n=7), (4) non-glycine missense variants within the triple helix (n=4 variants), and (5) non-glycine missense variants or in-frame insertions–deletions, in the N- or C-terminal part of the protein (n=8). Overall, our cohort confirmed the severity of the disease with a median age at first complication of 29 years (IQR 22–39), the most frequent being arterial (48%) and digestive (24%) ruptures. Groups 2 and 1 were significantly more severe than groups 3–5, with extreme median ages at first major complication of 23–47 years. Patients of groups 3–5 had a less typical phenotype and remarkably absence of digestive events. The distribution of glycine-replacing amino acids was strongly biased towards more destabilizing residues of the collagen assembly. Thus the natural course of vEDS and the clinical phenotype of patients are influenced by the type of COL3A1 variant. This study also confirms that patients with variants located in the C- and N-termini or leading to haplo-insufficiency have milder course of the disease and less prevalent diagnostic criteria. These findings may help refine diagnostic strategy, genetic counselling and clinical care. PMID:25758994

  7. Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart.

    PubMed

    Steendijk, P; Baan, J; Van der Velde, E T; Baan, J

    1998-09-01

    In this study we quantified the effects of a critical coronary stenosis on global systolic function using pressure-volume relations at baseline and during incremental dobutamine stress. The effects of coronary stenosis have previously been analyzed mainly in terms of regional (dys)function. Global hemodynamics are generally considered normal until coronary flow is substantially reduced. However, pressure-volume analysis might reveal mechanisms not fully exposed by potentially load-dependent single-beat parameters. Moreover, no systematic analysis by pressure-volume relations of the effects of dobutamine over a wide dose range has previously been presented. In 14 dogs left ventricular volume and pressure were measured by conductance and micromanometer catheters, and left circumflex coronary flow by Doppler probes. Measurements in control and with left circumflex stenosis were performed at baseline and at five levels of dobutamine (2.5 to 20 microg/kg/min). The end-systolic pressure-volume relation (ESPVR) dP/dtMAX vs. end-diastolic volume (dP/dtMAX - V(ED)) and the relation between stroke work and end-diastolic volume (preload recruitable stroke work [PRSW]) were derived from data obtained during gradual caval occlusion. In control, dobutamine gradually increased heart rate up to 20 microg/kg/min, the inotropic effect blunted at 15 microg/kg/min. With stenosis, the chronotropic effect was similar, however, contractile state was optimal at approximately 10 microg/kg/min and tended to go down at higher levels. At baseline, the positions of ESPVR and PRSW, but not of dP/dtMAX - V(ED), showed a significant decrease in function with stenosis. No differences between control and stenosis were present at 2.5 microg/kg/min; the differences were largest at 15 microg/kg/min. Pressure-volume relations and incremental dobutamine may be used to quantify the effects of critical coronary stenosis. The positions of these relations are more consistent and more useful indices than the

  8. Comparative Evaluation of Prevalence of Upper Cervical Vertebrae Anomalies in Cleft Lip/Palate Patients: A Retrospective Study

    PubMed Central

    Datana, Sanjeev; Kumar, Prasanna; Kumar Roy, Supriya; Londhe, Sanjay

    2014-01-01

    ABSTRACT% Purpose: The patients with cleft lip and palate have a higher risk of cervical vertebrae anomalies than do patients in general population. The aim of present study was to determine the prevalence of various upper cervical spine anomalies in different type of clefts. Procedures: Lateral cephalograms of 128 patients (66 males, 62 females) with cleft lip and palate, and 125 (60 males, 65 females) non syndromic patients without cleft lip and palate were selected at random from archive. Cephalograms of the patients were traced and the diagnosis of any cervical vertebrae anomaly was noted. Anomalies were categorized as either: posterior arch deficiency or fusions. Main findings: Prevalence of cervical vertebrae anomalies in the c lef t group was 20. 3% while it was 6.4% in the control group. Further cervical vertebrae anomalies were 16.6% in the CPO group, 19.1% in the BCLP group, and 22.2% in the UCLP group. Conclusion: A higher prevalence of cervical vertebrae anomalies was observed in cleft lip and palate patients. The prevalenc e obser ved is 3 times more in clef t group than c ontrol group. How to cite this article: Datana S, Bhalla A, Kumar P, Roy SK, Londhe S. Comparative Evaluation of Prevalence of Upper Cervical Vertebrae Anomalies in Cleft Lip/Palate Patients: A Retrospective Study. Int J Clin Pediatr Dent 2014;7(3):168-171. PMID:25709295

  9. Induction of human leukemia U937 cell apoptosis by an ethanol extract of Dendropanax morbifera Lev. through the caspase-dependent pathway.

    PubMed

    Lee, Joon Wοο; Park, Cheol; Han, Min Hο; Hong, Su Hyun; Lee, Tae Kyung; Lee, Shin Hwa; Kim, Gi-Young; Choi, Yung Hyun

    2013-09-01

    Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not yet been clearly elucidated. In the present study, we investigated the pro-apoptotic effects of an ethanol extract of D. morbifera stem bark (EEDM) on human leukemia U937 cells. EEDM markedly inhibited the growth of U937 cells by decreasing cell proliferation and inducing apoptosis. EEDM-induced apoptosis in U937 cells was associated with the upregulation of death receptor-related protein levels and downregulation of anti-apoptotic IAP family proteins. The increase in apoptosis was also associated with proteolytic activation of caspase-8, -9 and -3, inhibition of anti‑apoptotic Bcl-2 and Bcl-xL expression, Bid cleavage, and loss of MMP suggesting that apoptosis of U937 cells induced by EEDM was through the extrinsic and intrinsic pathways. However, a pan-caspase inhibitor, z-VED-fmk, significantly inhibited EEDM-induced U937 cell apoptosis indicating that the caspases were key regulators of apoptosis in response to EEDM in U937 cells. Our data suggest that D. morbifera may be a potential anticancer agent for cancer treatment.

  10. Induction of apoptosis by sarijang, a bamboo salt sauce, in U937 human leukemia cells through the activation of caspases

    PubMed Central

    CHOI, EUN-A; PARK, CHEOL; HAN, MIN-HO; LEE, JUN HYUK; KIM, GI-YOUNG; CHOI, BYUNG TAE; CHOI, YUNG HYUN

    2013-01-01

    Sarijang is a bamboo salt soy sauce, containing extracts of Rhynchosia nulubilis, sulfur-fed duck, dried bark of Ulmus davidiana and Allium sativum, which has been demonstrated to exert anti-inflammatory and antitumor activity. However, the cellular and molecular mechanisms of action of sarijang have not yet been elucidated. In the present study, we investigated the pro-apoptotic effects of sarijang in an in vitro U937 human leukemia cell model. Treatment with sarijang resulted in a concentration-dependent growth inhibition of the cells, coupled with the characteristic morphological features of apoptosis. The induction of the apoptotic cell death of the U937 cells by sarijang exhibited a correlation with the upregulation of death receptor 4 (DR4), the downregulation of members of the inhibitor of apoptosis protein (IAP) family, including survivin and cellular IAP (cIAP)-1, and the cleavage of Bid. Apoptosis-inducing concentrations of sarijang also induced the activation of caspases (caspase-3, -8 and -9), accompanied by proteolytic degradation of poly(ADP-ribose)-polymerase, β-catenin and phospholipase C-γ1. However, the apoptosis induced by sarijang was significantly inhibited by z-VED-fmk, a pan-caspase inhibitor, which demonstrated the importance of caspases in the process. These results suggested that sarijang may be a potential chemotherapeutic agent for use in the control of U937 human leukemia cells. Further studies are required to identify the active compounds in sarijang. PMID:24137193

  11. Kodymirus and the case for convergence of raptorial appendages in Cambrian arthropods.

    PubMed

    Lamsdell, James C; Stein, Martin; Selden, Paul A

    2013-09-01

    Kodymirus vagans Chlupáč and Havlíček in Sb Geol Ved Paleontol 6:7-20, 1965 is redescribed as an aglaspidid-like arthropod bearing a single pair of enlarged raptorial appendages, which are shown to be the second cephalic appendage. A number of early Palaeozoic arthropods, recognized from predominantly Cambrian Konservat-Lagerstätten, are known to have borne single pairs of large raptorial appendages. They are well established for the iconic yet problematic anomalocarids, the common megacheirans, and the ubiquitous bivalved Isoxys. Further taxa, such as fuxianhuiids and Branchiocaris, have been reported to have single pairs of specialized cephalic appendages, i.e., appendages differentiated from a largely homonomous limbs series, members of which act in metachronal motion. The homology of these raptorial appendages across these Cambrian arthropods has often been assumed, despite differences in morphology. Thus, anomalocaridids, for instance, have long multiarticulate "frontal appendages" consisting of many articles bearing an armature of paired serial spines, while megacheirans and Isoxys have short "great appendages" consisting of few articles with well-developed endites or elongate fingers. Homology of these appendages would require them to belong to the same cephalic segment. We argue based on morphological evidence that, to the contrary, the raptorial appendages of some of these taxa can be shown to belong to different cephalic segments and are the result of convergence in life habits. K. vagans is yet another important example for this, representing an instance for this morphology from a marginal marine environment.

  12. Adaptive regularization joint inversion of marine CSEM and MT data in vertically anisotropic stratified structures

    NASA Astrophysics Data System (ADS)

    Luo, M.; Li, Y.

    2016-12-01

    In inversion and interpretation of industrial EM data sets, it can be sufficient in a number of situations by assuming isotropy, however, the presence of electric anisotropy in the earth' s crust, due to thin layer interbedding or grain alignments in the sediments can significantly alter the response measured in the EM receiver. Ignoring anisotropy in interpreting marine CSEM data may lead to a distorted image of seabed conductivity structures, even misinterpretation. We present a joint inversion method for frequency domain marine CSEM data and MT data in vertically anisotropic stratified media. The inversion approach is based on the Gauss-Newton scheme. Due to the influence of ocean currents, the transmitter antenna will appear tilting and rotating. Applying superposition principle of electromagnetic field, we extend the scheme of Loseth and Ursin (2007) for calculating CSEM fields from a horizontal dipole source (HED) and/or a vertical dipole source (VED) in stratified media with vertical anisotropy to the general case of arbitrary orientation dipole source. The partial derivatives of the electromagnetic fileds (CSEM data) with respect to both the horizontal and vertical resistivity and apparent resistivity (MT data) with respect to the horizontal resistivity are analytically calculated. Based on the relationship between the horizontal resistivity and the vertical resistivity of the inversion model, an adaptive selection method for regularization factors is proposed to balance the effects of the data misfit and the structural constraint.

  13. Implications of Weak Link Effects on Thermal Characteristics of Transition-Edge Sensors

    NASA Technical Reports Server (NTRS)

    Bailey, C. N.; Adams, J. S.; Bandler, S. R.; Brekosky, R. P.; Chevenak, J. A.; Eckart, M. E.; Finkbeiner, F. M.; Kelley, R. L.; Kally, D. P.; Kilbourne, C. A.; hide

    2012-01-01

    Weak link behavior in transition-edge sensor (TES) microcalorimeters creates the need for a more careful characterization of a device's thermal characteristics through its transition. This is particularly true for small TESs where a small change in the bias current results in large changes in effective transition temperature. To correctly interpret measurements, especially complex impedance, it is crucial to know the temperature-dependent thermal conductance, G(T), and heat capacity, C(T), at each point through the transition. We present data illustrating these effects and discuss how we overcome the challenges that are present in accurately determining G and T from I-V curves. We also show how these weak link effects vary wi.th TES size. Additionally, we use this improVed understanding of G(T) to determine that, for these TES microcalorimeters. Kaptiza boundary resistance dominates the G of devices with absorbers while the electron-phonon coupling also needs to be considered when determining G for devices without absorbers

  14. Brain enhancing ingredients from Āyurvedic medicine: quintessential example of Bacopa monniera, a narrative review.

    PubMed

    Singh, Hemant K

    2013-02-06

    Āyurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of Āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of Āyurveda viz. Carak and Suśruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Suśruta had believed that these in combination with rasayana (rejuvenating) plants could enable an individual to lead a healthy life of 100 years.

  15. Robustness of tomographic reconstructors versus real atmospheric profiles in the ELT perspective

    NASA Astrophysics Data System (ADS)

    Gendron, E.; Morel, C.; Osborn, J.; Martin, O.; Gratadour, D.; Vidal, F.; Le Louarn, M.; Rousset, G.

    2014-08-01

    In this article we revisit a subject that has partly already been examined in previous studies: the behavior of tomographic reconstructors in adaptive optics systems, facing to an atmospheric profile (C2n(h)) different from the one they've been optimized for. We develop a new approach for that. The current usual approach is to simulate the performance of the reconstructor when slightly varying the C2n(h) profile around a nominal one, and show how far the deviation may go. This has the disadvantage that, as the parameter space for potential errors on the C2n(h) profile is basically infinite, it is particularly uneasy to span. Our approach consists in deriving a sort of sensitivity function, that we call vertical error distribution (VED), from the knowledge of any tomographic reconstructor. This function can be computed even for non-tomographic reconstructors, ground-layers reconstructors, single-conjugate AO reconstructors, etc. In any case, it allows us to derive the error when applied to a particular C2n(h) profile, have a direct, global visualization of the error variation with layer altitude, for any number at any altitude. This also allows us to understand what a given reconstructor is sensitive to, at what altitudes or altitude range, or explain why some GLAO reconstructors may perform better than optimized MMSE tomographic reconstructors if low-altitude layers pop up. We also discuss the case of ELTs and apply our approach to large scale reconstructors.

  16. Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction.

    PubMed

    Varadharaj, Saradhadevi; Porter, Kyle; Pleister, Adam; Wannemacher, Jacob; Sow, Angela; Jarjoura, David; Zweier, Jay L; Khayat, Rami N

    2015-02-01

    The mechanism of vascular endothelial dysfunction (VED) and cardiovascular disease in obstructive sleep apnea (OSA) is unknown. We performed a comprehensive evaluation of endothelial nitric oxide synthase (eNOS) function directly in the microcirculatory endothelial tissue of OSA patients who have very low cardiovascular risk status. Nineteen OSA patients underwent gluteal biopsies before, and after effective treatment of OSA. We measured superoxide (O2(•-)) and nitric oxide (NO) in the microcirculatory endothelium using confocal microscopy. We evaluated the effect of the NOS inhibitor l-Nitroarginine-Methyl-Ester (l-NAME) and the NOS cofactor tetrahydrobiopterin (BH4) on endothelial O2(•-) and NO in patient endothelial tissue before and after treatment. We found that eNOS is dysfunctional in OSA patients pre-treatment, and is a source of endothelial O2(•-) overproduction. eNOS dysfunction was reversible with the addition of BH4. These findings provide a new mechanism of endothelial dysfunction in OSA patients and a potentially targetable pathway for treatment of cardiovascular risk in OSA. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Low cost mobile explosive/drug detection devices

    SciTech Connect

    Gozani, T.; Bendahan, J.

    1999-06-10

    Inspection technologies based on Thermal Neutron Analysis (TNA) and/or Fast Neutron Analysis (FNA) are the basis for relatively compact and low-cost, material-sensitive devices for a wide variety of inspection needs. The TNA allows the use of either isotropic neutron sources such as a {sup 252}Cf, or electronic neutron generators such as the d-T sealed neutron generator tubes. The latter could be used in a steady state mode or in slow (>{mu}s) pulsing mode, to separate the thermal neutron capture signatures following the pulse from the combination of the FNA plus TNA signatures during the pulse. Over the years, Ancore Corporation has built and is continuing to develop a variety of inspection devices based on its TNA and FNA technologies: SPEDS--an explosive detection device for small parcels, portable electronics, briefcases and other similar carry-on items; MDS - a system for the detection or confirmation of buried mines; VEDS - a system for the detection of varied amounts of explosives and/or drugs concealed in passenger vehicles, pallets, lightly loaded trucks or containers, etc.; ACD - a device to clear alarms from a primary, non-specific explosive detection system for passenger luggage. The principle and performance of these devices will be shown and discussed.

  18. Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure.

    PubMed

    Duque, Gustavo Salgado; Silva, Dayse Aparecida da; Albuquerque, Felipe Neves de; Schneider, Roberta Siuffo; Gimenez, Alinne; Pozzan, Roberto; Rocha, Ricardo Mourilhe; Albuquerque, Denilson Campos de

    2016-11-01

    pacientes com IC de etiologia isquêmica de uma população do Rio de Janeiro e sua associação com achados ecocardiográficos. Avaliação genética do polimorfismo I/D da ECA associada a análise de dados clínicos, laboratoriais e ecocardiográficos de 99 pacientes. Foram encontrados 53 alelos I, 145 alelos D, quanto aos genótipos da ECA: 49,5% DD, 47,48% DI, 3,02% II. O tratamento medicamentoso foi otimizado com 98% usando betabloqueadores e 84,8%, IECA ou bloqueador do receptor de angiotensina. Achados ecocardiográficos: diferença entre os diâmetros diastólicos do ventrículo esquerdo (ΔVED): 2,98±8,94 (DD) vs. 0,68±8,12 (DI) vs. -11,0±7,00 (II), p=0,018; piora evolutiva do diâmetro sistólico do VE (VES): 65,3 % DD vs. 19,0 % DI vs. 0,0 % II, p=0,01; do diâmetro diastólico do VE (VED): 65,3 % DD vs. 46,8 % DI vs. 0,0 % II, p=0,03; e da fração de ejeção do VE (FEVE): 67,3 % DD vs. 40,4 % DI vs. 33,3 % II, p=0,024. Correlação com alelo D: ΔFEVE, ΔVES, ΔVED. Foram identificados mais pacientes com piora evolutiva da FEVE e dos diâmetros cavitários do VE no genótipo DD, seguido do DI, sendo o II o de melhor evolução. O mesmo padrão foi observado na ΔVED.

  19. Recreational Industry in the North of European Russia: Case Assessment, Komi Republic

    NASA Astrophysics Data System (ADS)

    Yakovleva, M. P.; Kuchkina, E.; Iyevlev, N.; Lyaskovsky, S.

    2012-12-01

    At the past AGU Annual Meeting in 2011, we presented information about development of the recreation industry in European Russia within the "Silver Ring" Project (http://neespi.org/web-content/meetings/AGU_2011/Yakovleva-poster.pdf). This Project can be considered as a system of actions directed to a comprehensive socio-economic development of the Northwest of the Russian Federation that includes 11 provinces ("oblast", "republic", "okrug") of the country. Among the provinces included in the Project, The Komi Republic is one of the most interesting regions. The Komi Republic is located in the North of European Russia within the gridbox restricted by 59N - 69N latitudes and 45E - 66E longitudes. The region is populated by indigenous northern nations: Komi, Russians, Karels, Ved', Permyaks, and others. It is characterized as an ecologically clean territory, has a small population density, is rich with natural reserves, and has abundant forest and water resources. Flora and fauna of the Republic are unique and attractive. Rich biodiversity and abundance of fish and game allow hunting and sport fishing. As of January 1, 2010, The Komi Republic has 240 territories of special environmental protection ("zakazniki") with restricted human activity. This allows a diversity of field trips devoted to in-depth studies of regional ecosystems as well as tourist visits aiming to enjoy unique nature and ethnic-cultures of the North.

  20. Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children.

    PubMed

    Qi, Y-J; Niu, Q-L; Zhu, X-L; Zhao, X-Z; Yang, W-W; Wang, X-J

    2016-12-01

    To investigate the relationship between vitamin A deficiency (VAD), vitamin E deficiency (VED) and infectious diseases. We chose 684 cases of healthy children age 5 months-12 years from our hospital, measured their VA, VE from vein under the light proof condition with high-pressure liquid chromatography. Thereafter, the children who get the acute respiratory tract infection (ARI) or diarrhea two weeks later were registered. After the two weeks trial (N=684 cases), the VA level of children with ARI was lower than that of children without ARI (0.23±0.02 mg/ml/0.33±0.01 mg/ml), p<0.05. Moreover, the VE level of children with ARI was significantly lower than that of children without ARI (p<0.05). Most interestingly, the proportion of children with diarrhea accompanied with decreased VA level in serum was higher than that of children without diarrhea, indicating that VA level <0.2 mg/L more easily affected acute respiratory tract infection. We were able to demonstrate that Children who presented vitamin A deficiency were easier to get the acute respiratory tract infection (ARI) and diarrhea. Children who presented vitamin E deficiency were easier to get the acute respiratory tract infection (ARI). Vitamin A and vitamin E deficiencies are one of the important factors related to occurrences of acute infectious diseases in children.

  1. Orbiting transmitter and antenna for spaceborne communications at ELF/VLF to submerged submarines

    NASA Technical Reports Server (NTRS)

    Bannister, P. R.; Harrison, J. K.; Rupp, C. C.; King, R. W. P.; Cosmo, M. L.; Lorenzini, E. C.; Dyer, C. J.; Grossi, M. D.

    1993-01-01

    An orbital emplacement for the transmitter and the antenna of a communications link at ELF (30 to 300 Hz) and VLF (3 kHz to 30 kHz) to submerged submarines has been considered since the very inception of the space age. However, only recently has space technology reached a sufficient level of maturity for system designers to undertake serious studies of this link configuration. The optimistic outlook stems from recent space technology developments, such as the design and construction by NASA of long orbiting tethers, and the testing, onboard Shuttle Orbiter ATLANTIS, of the first spaceborne 20 km metal wire. This is known as the Tethered Satellite System-1 (TSS-1), a space mission that might be possibly followed by other flights, with tether lengths that could reach 100 km. Once deployed at a height of, say, 300 km, from a Shuttle Orbiter, or from another suitable platform, a long, thin tether aligns itself along the local vertical by virtue of the gradient of the Earth gravity field. If made of metal, the tether can function as a VED (Vertical Electric Dipole) transmitting antenna at ELF and VLF.

  2. Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

    PubMed Central

    Singh, Hemant K.

    2013-01-01

    Āyurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of Āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of Āyurveda viz. Carak and Suśruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Suśruta had believed that these in combination with rasayana (rejuvenating) plants could enable an individual to lead a healthy life of 100 years. PMID:23389306

  3. Combination therapy for erectile dysfunction: an update review

    PubMed Central

    Dhir, Rohit R; Lin, Hao-Cheng; Canfield, Steven E; Wang, Run

    2011-01-01

    The introduction of oral phosphodiesterase-5 inhibitors (PDE5Is) in the late 1990s and early 2000s revolutionized the field of sexual medicine and PDE5Is are currently first-line monotherapy for erectile dysfunction (ED). However, a significant proportion of patients with complex ED will be therapeutic non-responders to PDE5I monotherapy. Combination therapy has recently been adopted for more refractory cases of ED, but a critical evaluation of current combination therapies is lacking. A thorough PubMed and Cochrane Library search was conducted focusing on the effectiveness of combination therapies for ED in therapeutic non-responders to PDE5I therapy. Journal articles spanning the time period between January 1990 and December 2010 were reviewed. Criteria included all pertinent review articles, randomized controlled trials, cohort studies and retrospective analyses. References from retrieved articles were also manually scanned for additional relevant publications. Published combination therapies include PDE5I plus vacuum erectile device (VED), intraurethral medication, intracavernosal injection (ICI), androgen supplement, α-blocker or miscellaneous combinations. Based on this review, some of these combination treatments appeared to be quite effective in preliminary testing. Caution must be advised, however, as the majority of combination therapy articles in the last decade have numerous limitations including study biases and small subject size. Regardless of limitations, present combination therapy research provides a solid foundation for future studies in complex ED management. PMID:21423198

  4. Anxiety disorders in ancient Indian literature

    PubMed Central

    Sheth, Hitesh C.; Gandhi, Zindadil; Vankar, G. K.

    2010-01-01

    In western literature, the oldest description of symptoms of PTSD, an anxiety group of disorder, is seen in Homer’s Iliad written around 720 BC. According to Shay, Achilles was suffering from symptoms of PTSD. However, in the Indian literature it was mentioned around 5000 BC. The description of a PTSD-like syndrome is seen in the Ramayana, although it was not described as PTSD or by any other similar name. Ravana’s brother Marrich was having symptoms of PTSD after he was grievously hurt by Lord Rama’s arrow and was almost dead. This traumatic event threatened his physical integrity. He developed all the symptoms of PTSD, like hyper-arousal, re-experiencing the events and avoidance. He also gave up his natural work of harassing the monk and got engaged in meditation and austerities. His symptoms lasted for many years till Lord Rama killed him, while he was masquerading as a golden deer to deceive Sita. In another ancient epic Shrimad Bhagavatam, Maharshi Ved Vyasa described the symptoms of Generalized Anxiety Disorder (GAD). The demon King Kansha developed GAD-like symptoms, when Lord Krishna killed all his demons and threatened to kill him. He developed symptoms of GAD, like excessive worry about the attack from his arch foe Krishna, difficulty in concentration and difficulty in falling asleep. Like Marrich, the symptoms of Kansha also lasted until Lord Krishna killed him. PMID:21180424

  5. Implications of Weak Link Effects on Thermal Characteristics of Transition-Edge Sensors

    NASA Technical Reports Server (NTRS)

    Bailey, C. N.; Adams, J. S.; Bandler, S. R.; Brekosky, R. P.; Chevenak, J. A.; Eckart, M. E.; Finkbeiner, F. M.; Kelley, R. L.; Kally, D. P.; Kilbourne, C. A.; Porter, F. S.; Sadleir, J. E.; Smith, S. J.

    2012-01-01

    Weak link behavior in transition-edge sensor (TES) microcalorimeters creates the need for a more careful characterization of a device's thermal characteristics through its transition. This is particularly true for small TESs where a small change in the bias current results in large changes in effective transition temperature. To correctly interpret measurements, especially complex impedance, it is crucial to know the temperature-dependent thermal conductance, G(T), and heat capacity, C(T), at each point through the transition. We present data illustrating these effects and discuss how we overcome the challenges that are present in accurately determining G and T from I-V curves. We also show how these weak link effects vary wi.th TES size. Additionally, we use this improVed understanding of G(T) to determine that, for these TES microcalorimeters. Kaptiza boundary resistance dominates the G of devices with absorbers while the electron-phonon coupling also needs to be considered when determining G for devices without absorbers

  6. Realism Assessment of Sonic Boom Simulators

    NASA Technical Reports Server (NTRS)

    Sullivan, Brenda M.; Davies, Patrica; Hodgdon, Kthleen K.; Salamone, Joseph A., III; Pilon, Anthony

    2008-01-01

    Developments in small supersonic aircraft design are predicted to result in low-intensity sonic booms. Booms generated by current aircraft are similar to those that led to the ban on commercial supersonic fli ght over the US, so are unsuitable for parametric studies of psychoac oustic response to low-intensity booms. Therefore, simulators have be en used to study the impact of predicted low-intensity sonic booms. H owever, simulators have been criticized because, when simulating conv entional-level booms, the sounds were observed to be unrealistic by p eople experienced in listening to sonic booms. Thus, two studies were conducted to measure the perceived realism of three sonic boom simul ators. Experienced listeners rated the realism of conventional sonic boom signatures when played in these simulators. The effects on percei ved realism of factors such as duration of post-boom noise, exclusion of very low frequency components, inclusion of ground reflections, a nd type of simulator were examined. Duration of post-boom noise was f ound to have a strong effect on perceived realism, while type of simu lator had a weak effect. It was determined that post-boom noise had t o be at least 1.5 seconds long for the sound to be rated very realist ic. Loudness level did not affect realism for the range of sounds pla yed in the tests (80-93 dB ASEL).

  7. Realism Assessment of Sonic Boom Simulators

    NASA Technical Reports Server (NTRS)

    Sullivan, Brenda M.; Davies, Patrica; Hodgdon, Kthleen K.; Salamone, Joseph A., III; Pilon, Anthony

    2008-01-01

    Developments in small supersonic aircraft design are predicted to result in low-intensity sonic booms. Booms generated by current aircraft are similar to those that led to the ban on commercial supersonic fli ght over the US, so are unsuitable for parametric studies of psychoac oustic response to low-intensity booms. Therefore, simulators have be en used to study the impact of predicted low-intensity sonic booms. H owever, simulators have been criticized because, when simulating conv entional-level booms, the sounds were observed to be unrealistic by p eople experienced in listening to sonic booms. Thus, two studies were conducted to measure the perceived realism of three sonic boom simul ators. Experienced listeners rated the realism of conventional sonic boom signatures when played in these simulators. The effects on percei ved realism of factors such as duration of post-boom noise, exclusion of very low frequency components, inclusion of ground reflections, a nd type of simulator were examined. Duration of post-boom noise was f ound to have a strong effect on perceived realism, while type of simu lator had a weak effect. It was determined that post-boom noise had t o be at least 1.5 seconds long for the sound to be rated very realist ic. Loudness level did not affect realism for the range of sounds pla yed in the tests (80-93 dB ASEL).

  8. Specificity of Atmosphere Correction of Satellite Ocean Color Data in Far-Eastern Region

    NASA Astrophysics Data System (ADS)

    Trusenkova, O.; Kachur, V.; Aleksanin, A. I.

    2016-02-01

    It was carried out an error analysis of satellite reflectance coefficients (Rrs) of MODIS/AQUA colour data for two atmospheric correction algorithms (NIR, MUMM) in the Far-Eastern region. Some sets of unique data of in situ and satellite measurements have been analysed. A set has some measurements with ASD spectroradiometer for each satellite pass. The measurement allocations were selected so the Chlorophyll-a concentration has high variability. Analysis of arbitrary set demonstrated that the main error component is systematic error, and it has simple relations on Rrs values. The reasons of such error behavior are considered. The most probable explanation of the large errors of oceanic color parameters in the Far-Eastern region is the ability of high concentrations of continental aerosol. A comparison of satellite and in situ measurements at AERONET stations of USA and South Korea regions has been made. It was shown that for NIR-correction of the atmosphere influence the error values in these two regions have differences up to 10 times for almost the same water turbidity and relatively good accuracy of computation of aerosol optical thickness. The study was supported by grant Russian Scientific Foundation No. 14-50-00034, by grant of Russian Foundation of Basic Research No.15-35-21032-mol-a-ved, and by Program of Basic Research "Far East" of Far Eastern Branch of Russian Academy of Sciences.

  9. Vitamin E deficiency reduced lumbar bone calcium content in female rats.

    PubMed

    Norazlina, M; Chua, C W; Ima-Nirwana, S

    2004-12-01

    Vitamin E deficiency has been found to impair bone calcification. This study was done to determine the effects of vitamin E deficiency and supplementation on parathyroid hormone, i.e. the hormone involved in bone regulation. Female Sprague-Dawley rats were divided into 4 groups: 1) normal rat chow (RC), 2) vitamin E deficiency (VED), vitamin E deficient rats supplemented with 3) 60 mg/kg alpha-tocotrienol (ATT) and 4) 60 mg/kg (alpha-tocopherol (ATF). Treatment was carried out for 3 months. Vitamin E deficiency caused hypocalcaemia during the first month of the treatment period, increased the parathyroid hormone level in the second month and decreased the bone calcium content in the 4th lumbar bone at the end of the treatment. Vitamin E supplementation (ATT and ATF) failed to improve these conditions. The bone formation marker, osteocalcin, and the bone resorption marker, deoxypyridinoline did not change throughout the study period. In conclusion vitamin E deficiency impaired bone calcium homeostasis with subsequent secondary hyperparathyroidism and vertebral bone loss. Replacing the vitamin E with pure ATF or pure ATT alone failed to correct the changes seen.

  10. Two models of inventory control with supplier selection in case of multiple sourcing: a case of Isfahan Steel Company

    NASA Astrophysics Data System (ADS)

    Rabieh, Masood; Soukhakian, Mohammad Ali; Mosleh Shirazi, Ali Naghi

    2016-03-01

    Selecting the best suppliers is crucial for a company's success. Since competition is a determining factor nowadays, reducing cost and increasing quality of products are two key criteria for appropriate supplier selection. In the study, first the inventories of agglomeration plant of Isfahan Steel Company were categorized through VED and ABC methods. Then the models to supply two important kinds of raw materials (inventories) were developed, considering the following items: (1) the optimal consumption composite of the materials, (2) the total cost of logistics, (3) each supplier's terms and conditions, (4) the buyer's limitations and (5) the consumption behavior of the buyers. Among diverse developed and tested models—using the company's actual data within three pervious years—the two new innovative models of mixed-integer non-linear programming type were found to be most suitable. The results of solving two models by lingo software (based on company's data in this particular case) were equaled. Comparing the results of the new models to the actual performance of the company revealed 10.9 and 7.1 % reduction in total procurement costs of the company in two consecutive years.

  11. Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs.

    PubMed

    Schnorr, Jörg; Wagner, Susanne; Abramjuk, Claudia; Wojner, Ines; Schink, Tania; Kroencke, Thomas J; Schellenberger, Eyk; Hamm, Bernd; Pilgrimm, Herbert; Taupitz, Matthias

    2004-09-01

    VSOP-C184 at a dose of 0.045 mmol Fe/kg has been shown to be an efficient blood pool contrast medium for equilibrium magnetic resonance angiography (MRA) that can be administered as a bolus. The present study was performed to determine whether VSOP-C184 is also suitable for first-pass MRA. Fifteen MRA examinations at 1.5 T were performed in minipigs using a fast 3D fast low-angle shot (FLASH) sequence (repetition time = 4.5 ms, echo time = 1.7 ms, excitation angle = 25 degrees, matrix 256, body phased-array coil). The citrate-stabilized iron oxide preparation VSOP-C184 was investigated (total particle diameter: 7.0 +/- 0.15 nm; core size: 4 nm) and compared with gadopentetate dimeglumine (Gd-DTPA). The following doses were tested: VSOP-C184: 0.015, 0.025, and 0.035 mmol Fe/kg; Gd-DTPA: 0.1 and 0.2 mmol Gd/kg; n = 3 examinations/dose. Data were analyzed quantitatively (signal enhancement (ENH) and vessel edge definition (VED)) and qualitatively. First-pass MRA using the 3 doses of VSOP-C184 yielded the following ENH: aorta: 9.4 +/- 2.6; 12.31 +/- 1.2; 16.53 +/- 1.7; renal arteries: 7.6 +/- 2.2; 9.9 +/- 1.0; 13.2 +/- 0.5. The values for the 2 doses of Gd-DTPA were aorta: 12.9 +/- 1.0; 16.8 +/- 2.2; renal arteries: 11.2 +/- 1.23; 11.3 +/- 1.7. VED for the 3 doses of VSOP-C184 was aorta: 106.3 +/- 31.0; 135.3 +/- 58.8; 141.3 +/- 71.0; renal arteries: 102.2 +/- 24.3; 146.8 +/- 63.0; 126.9 +/- 37.6 and for the 2 doses of Gd-DTPA, aorta: 157.2 +/- 47.8; 164.2 +/- 36.8; renal arteries: 165.9 +/- 30.4; 170.3 +/- 38.2 respectively. The differences between VSOP-C184 and Gd-DTPA are clinically not relevant and statistically not significant (p > or = .05). Qualitative evaluation of image quality, contrast, and delineation of vessels showed the results obtained with VSOP-C184 at doses of 0.025 and 0.035 mmol Fe/kg to be similar to those of Gd-DTPA at 0.1 and 0.2 mmol Gd/kg. VSOP-C184 is suitable for first-pass MRA at doses of 0.025 and 0.035 mmol Fe/kg and thus, in addition to

  12. Towards the mid-infrared optical biopsy

    NASA Astrophysics Data System (ADS)

    Seddon, Angela B.; Benson, Trevor M.; Sujecki, Slawomir; Abdel-Moneim, Nabil; Tang, Zhuoqi; Furniss, David; Sojka, Lukasz; Stone, Nick; Jayakrupakar, Nallala; Lloyd, Gavin R.; Lindsay, Ian; Ward, Jon; Farries, Mark; Moselund, Peter M.; Napier, Bruce; Lamrini, Samir; Møller, Uffe; Kubat, Irnis; Petersen, Christian R.; Bang, Ole

    2016-03-01

    We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the midinfrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy (`opsy' look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR- infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).

  13. Competitive Low Pressure Oxygen Plasma Interactions with Different= Carbon-Carbon Double Bonds

    NASA Astrophysics Data System (ADS)

    Patiño, P.; Sifontes, A.; Gambús, G.

    1999-10-01

    Recently we have shown advances from reactions of O(^3P) with both, l ong-chain hydrocarbons and refinery residuum. The oxidation products of t he process, a mixture of alcohols, epoxides and carbonyl compounds, might have potential properties as additives in formulating fuels. This work s hows the results of the interactions of an oxygen plasma with double bond s, both olefin and aromatic, in the same compound. The reactions have bee n carried out by making the plasma, created by a high voltage glow discha rge, reach the low vapor pressure surface of liquid 4-phenyl-1-butene. Th is (3 mL) was cooled down to -45 ^oC in a glass reactor, applied power was 24 W, at an oxygen pressure of 20 Pa. Products were analyzed by IR, N MR and mass spectroscopies. Conversions were studied as a function of the reaction time, this ranging from 5 to 120 minutes. At short times the O( ^3P) atoms produced in the discharge only reacted with the alkene fra ction of the hydrocarbon, 4-phenyl-1,2-epoxibutane (52%) and 4-phenyl-bu tanal (48%) being the products. Reactions on the benzene ring were obser ved from about 30 minutes on, the corresponding phenols having being prod uced at ratios ortho:para:meta :: 4:1:0.7. At 120 minutes, the ol efin have been completely oxidized and a low fraction of the non-equivale nt two methylene groups have reacted to produce alcohols and ketones.

  14. Developing of the database of meteorological and radiation fields for Moscow region (urban reanalysis) for 1981-2014 period with high spatial and temporal resolution. Strategy and first results.

    NASA Astrophysics Data System (ADS)

    Konstantinov, Pavel; Varentsov, Mikhail; Platonov, Vladimir; Samsonov, Timofey; Zhdanova, Ekaterina; Chubarova, Natalia

    2017-04-01

    The main goal of this investigation is to develop a kind of "urban reanalysis" - the database of meteorological and radiation fields under Moscow megalopolis for period 1981-2014 with high spatial resolution. Main meteorological fields for Moscow region are reproduced with COSMO_CLM regional model (including urban parameters) with horizontal resolution 1x1 km. Time resolution of output fields is 1 hour. For radiation fields is quite useful to calculate SVF (Sky View Factor) for obtaining losses of UV radiation in complex urban conditions. Usually, the raster-based SVF analysis the shadow-casting algorithm proposed by Richens (1997) is popular (see Ratti and Richens 2004, Gal et al. 2008, for example). SVF image is obtained by combining shadow images obtained from different directions. An alternative is to use raster-based SVF calculation similar to vector approach using digital elevation model of urban relief. Output radiation field includes UV-radiation with horizontal resolution 1x1 km This study was financially supported by the Russian Foundation for Basic Research within the framework of the scientific project no. 15-35-21129 _mol_a_ved and project no 15-35-70006 mol_a_mos References: 1. Gal, T., Lindberg, F., and Unger, J., 2008. Computing continuous sky view factors using 3D urban raster and vector databases: comparison and application to urban climate. Theoretical and applied climatology, 95 (1-2), 111-123. 2. Richens, P., 1997. Image processing for urban scale environmental modelling. In: J.D. Spitler and J.L.M. Hensen, eds. th Intemational IBPSA Conference Building Simulation, Prague. 3. Ratti, C. and Richens, P., 2004. Raster analysis of urban form. Environment and Planning B: Planning and Design, 31 (2), 297-309.

  15. Effects of Vitamin C or E on the Pro-inflammatory Cytokines, Heat Shock Protein 70 and Antioxidant Status in Broiler Chicks under Summer Conditions.

    PubMed

    Jang, In-Surk; Ko, Young-Hyun; Moon, Yang-Soo; Sohn, Sea-Hwan

    2014-05-01

    The present study was carried out to investigate the effects of dietary antioxidants on pro-inflammatory cytokines, heat shock protein (HSP) and antioxidant status in broiler chicks under summer conditions. A total of 162, 3-d-old broiler chicks were randomly assigned to a basal diet (CON) and the basal diet supplemented with vitamin C (200 mg/kg diet, VCD) or vitamin E (100 mg/kg, VED) until 35 day of age. All birds were exposed to summer diurnal heat stress at average daily fluctuations of temperature between 32°C to 34°C at day to 27°C to 29°C at night for the entire feeding periods. There was no significant difference in body weight, feed to gain ratio and the relative organ weight except the thymus in response to dietary vitamin C or E supplementation. However, the mRNA expression of interleukin (IL)-1β, IL-6, interferon (IFN)-γ, Toll like receptor (TLR)-4 and HSP70 in the liver of birds fed diet containing vitamin C significantly (p<0.05) decreased compared with those in birds fed basal diet. Dietary vitamin E also showed a significant (p<0.05) decrease in the mRNA expression of IL-6 and HSP70 compared with a basal diet. Total antioxidant status (TAS) in serum of birds fed vitamin C supplemented diet was significantly (p<0.05) higher with than that in birds a basal diet. Lipid peroxidation in serum and liver resulted in a significant (p<0.05) decrease in response to dietary vitamin C or E supplementation. In conclusion, dietary supplementation with antioxidant vitamins, especially vitamin C resulted in a significant decrease in the mRNA expression of pro-inflammatory cytokines and HSP70, and higher antioxidant parameters than that of birds on the basal diet under summer conditions.

  16. Continuous quality improvement in intensive care medicine. The GiViTI Margherita Project - Report 2005.

    PubMed

    Boffelli, S; Rossi, C; Anghileri, A; Giardino, M; Carnevale, L; Messina, M; Neri, M; Langer, M; Bertolini, G

    2006-06-01

    The assessment of the quality of intensive care medicine is mandatory in the modern healthcare system. In Italy, the GiViTI (Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva) network is working in this field since 1991 and it now involves 295 out of the about 450 Italian intensive care units (ICU). In 2002 GiViTI launched a project for the continuous quality assessment and improvement that is now joined by 180 ICUs. Data collected in 2005 are analyzed and presented. All admitted patients were entered in a validated software, which performs a multitude of validity checks during the data entry. Data were further reviewed by the co-ordinating center; patients admitted in months with more than 10% of incomplete or inconsistent records in each ICU were excluded from the analysis. Each year, a multivariate logistic regression model is fitted to identify predictors of hospital mortality. Starting from the SAPS 2 and the 2004 GiViTI model predictions of hospital mortality, two calibration tables and curves are presented. In 2005, 180 Italian ICUs collected data on 55 246 patients. After excluding those admitted in months with an unjustified lower recruitment rate or with less than 90% of complete and consistent data, we had 52 816 (95.6%) valid cases. Although the rough hospital mortality in 2005 was 1% higher than in 2004 (22.6% vs 21.5%), the adjusted mortality shows a statistically significant 4% reduction (obser-ved-to-expected ratio: 0.96; 95% CI: 0.94-0.97). Italian ICUs in 2005 performed better than in 2004, at a parity of patient severity.

  17. Fatigue test results of the rotating steel blades of steam turbine K-25-0.6 GEO with ion-plasma coating

    NASA Astrophysics Data System (ADS)

    Kachalin, G. V.; Mednikov, A. F.; Tkhabisimov, A. B.; Arkad'ev, D. A.; Temkin, S. G.; Senina, N. A.

    2016-12-01

    Fatigue test results of the rotating steel blades of the fourth stage of the K-25-0.6 low pressure cylinder Geo steam turbine manufactured in the Kaluga Turbine Plant (hereinafter, KTP) with the ion-plasma coating were presented. Coating formation was carried out at the National Research University (MPEI) on the Gefest vacuum pilot plant by the magnetron sputtering method. Characteristics of the obtained coating were analyzed with the use of the scientific-research equipment of the National Research University (MPEI). Fatigue tests of the rotating blades and determination of the fatigue strength of the material with the ion-plasma coating were carried out on the electrodynamic vibration machines VEDS-400A in the KTP structural laboratory. The following characteristics were obtained after tests: Ti-TiN composition, 10-11 μm thickness, 1200 HV 0.05 microhardness. Fatigue tests showed that destruction, regardless of availability or nonavailability of the coating, took place by cross-section in the root zone both on the leading and trailing edges of the blade, i.e., in the most stressed zones. It was found out that the maximum stresses during tests were revealed in the root section along the trailing edge on the blade pressure side, and the less stresses were on the leading edge. Fatigue strength of the working blades after coating formation increased by 12% minimum. Results of the fatigue tests prove the previously obtained data concerning 10-12% increase of the fatigue strength of the blade steel with the ion-plasma coating and allow claiming that the process of their formation exerts the positive influence on the fatigue characteristics of the blade materials.

  18. Theoretical, Computational, and Experimental Studies of a Metamaterial-Enhanced Resistive Wall Amplifier

    NASA Astrophysics Data System (ADS)

    Rowe, Raymond Tyler

    This project focuses on a specific vacuum electron device (VED), the resistive wall amplifier (RWA). The RWA passes a velocity-modulated electron beam near a resistive surface to amplify electromagnetic signals. It was originally introduced in 1950 and received limited further theoretical and experimental investigation. The original investigators demonstrated that if the admittance of the RWA's wall was resistive or resistive-inductive (as seen by the electron beam), the device would support a growing space charge wave and produce gain. However, when constructing a practical device a dielectric substrate is necessary to support the resistive medium. The addition of a dielectric introduces a capacitive component to the wall's admittance (less inductive), reducing the device's performance. This work investigates how metamaterials (MTMs) can improve the RWA performance. MTMs are composite structures engineered to have electromagnetic (EM) properties that are not readily available in nature (e.g., negative permittivity and/or permeability). The metamaterial enhanced resistive wall amplifier (MERWA) was theoretically, computationally, and experimentally investigated in this work. The analytic theory investigation revealed how the addition of an epsilon negative (ENG) medium liner could make the wall's admittance more inductive and enhance the gain-bandwidth product of a RWA. We then examined how a periodic, inductively-meandered, metal wire array could be used as an ENG MTM medium for the MERWA. Finally, we developed and analyzed a relativistic analytic theory MERWA model. The computational portion of the MERWA investigation included EM and particle-in-cell (PIC) studies of the ENG-medium-lined RWA and the inductively-meandered, metal-wire-array, MTM-lined MERWA realization. The computational simulation results agreed well with the analytic theory predictions. Finally, the experimental investigation of the MERWA included design, fabrication, assembly and measurements of

  19. Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium.

    PubMed

    Manosroi, A; Jantrawut, P; Manosroi, J

    2008-08-06

    The objective of this study was to develop a novel elastic bilayer vesicle entrapped with the non-steroidal anti-inflammatory drug (NSAID), diclofenac diethylammonium (DCFD) for topical use. Eighteen bilayer vesicular formulations composing of DPPC or Tween 61 or Span 60 mixed with cholesterol (at 1:1, 3:7 and 1:1 molar ratios, respectively) and ethanol at 0-25% (v/v), by chloroform film method with sonication were developed. The elastic Tween 61 niosomes which gave no sedimentation, no layer separation, unchanged particle sizes (about 200 nm) were selected to entrap DCFD. The entrapment efficiency of the drug in the conventional and elastic Tween 61 niosomes was 65 and 93%, respectively. At least 87% of DCFD determined by HPLC remained in elastic Tween 61 niosomes when kept at 4, 27 and 45 degrees C for 3 months. The deformability index values of the elastic niosomes were 13.76 and 3.44 times higher than the conventional niosomes entrapped and not entrapped with the drug, respectively, indicating the higher flexibility of the elastic vesicle especially, when entrapped with the drug. Transdermal absorption through excised rat skin was performed by vertical Franz diffusion cell at 32+/-2 degrees C for 6h. Gel containing elastic niosomes exhibited fluxes of DCFD in the stratum corneum (SC), deeper skin layer (viable epidermis and dermis, VED) and receiver chamber at 191.27+/-9.52, 16.97+/-2.77 and 3.76+/-0.54 microg/(cm2 h), whereas the commercial emulgel, containing an equivalent DCFD, gave 60.84+/-13.63, 7.33+/-1.70 and 0.14+/-0.01 microg/(cm2 h), respectively. The in vivo anti-inflammatory activity was evaluated by ethyl phenylpropiolate (EPP)-induced rat ear edema (n=3). DCFD entrapped in the developed elastic niosomes and incorporated in gel gave the same ear edema inhibition percentages of 23.81% at 30 min, but 2 and 9 times more inhibition percentages at 45 and 60 min than the commercial emulgel, respectively. This result has not only demonstrated the

  20. Misho mafic complex - A part of paleotethyan oceanic crust or a magmatism in continental rift?

    NASA Astrophysics Data System (ADS)

    Azimzadeh, Zohreh; Jahangiri, Ahmad; Saccani, Emilio; Dilek, Yildirim

    2013-04-01

    Misho Mafic Complex (NW Iran) represents a significant component of the West Cimmerian domain in Paleo-Tethys. The Misho Mafic Complex (MMC) consists of gabbro (mainly) and norıte,olivine gabbro, anorthosite and diorite with the east- west sereight. MMC has ıntrussıved ın Kahar sedımrtery Infta- Cambrıan rocks, crosscut by abundant basaltic dykes and the overlying basaltic sheeted dyke complex. Kahar sedimentary rocks are representing the northern margin of Gondwana. Misho mafic complex are covered by Permian sedimentary rocks. The gabbros and basaltic dykes have MORB affinities. MMC formed as a product of interactions between a depleted MORB-type asthenosphere and plume-type material. Mafic rocks represent an early Carboniferous magmatic event developed during the continental break-up of the northern edge of Gondwanaland that led to the opening of Paleotethys. Alternatively, these magmas may have been emplaced into the continental crust at the continental margin soon after the oceanic crust was formed (that is the oceanic crust was still narrow). There is no data for discriminating between these two hypotheses. In first hypothesis MMC is a part of ophiolites related to paleotethyan oceanic crust and the rocks that were above this crustal level should have necessarily been eroded. In another hypothesis Misho complex represents an aborted rift in a triple junction. Above a mantle plume, the continental crust breaks along three directions at 120 degrees. But, soon after, the extension proceeds along two of these three direction. Between them is formed the oceanic crust. The continental extension along the third direction is aborted. Here no oceanic crust if formed and there is only rifted, thinned continental crust. But, also in the aborted branch MORB magmatism can occur for short time. In this hypothesis, the Misho complex was never associated with oceanic crust, but was anyway associated with the opening of the Paleotethys. This magmatism was originally

  1. Tango in the Mid-Jurassic: 10,000-Yr Geomagnetic Field Reversals

    NASA Astrophysics Data System (ADS)

    Steiner, M.

    2001-12-01

    A continuous magnetostratigraphic signature of Layer 2A from Jurassic Quiet Zone (JQZ) oceanic crust now is known from two separate paleo-magnetic data sets. Measurement/demagnetization along the length of the entire core at 5-cm intervals generated ~100,000 data points, whereas a suite of 472 discrete samples also were taken from throughout the core. Both data sets display the same magnetization pattern, a series of repeated sinusoidal inclination changes downhole. Six inter-vals of maximum inclination (three positive, three negative) are obser-ved. Maximum inclination intervals of +/-40° are separated by regions of smoothly varying intermediate inclination values. Despite lack of azmuithal orientation of the core, downhole magnetic logging (Larson et al., in prep.) shows full ~360° directional change in the magnetization vector. Therefore, the maximum inclination regions represent polarity intervals of the geomagnetic field, and six polarity intervals in stacked sequence are contained in the upper 400 m thickness of Layer 2A at this site. The time duration spanned by these six reversals was estimated from recent seismic studies of young ocean crustal construction on the East Pacific Rise (EPR). Estimates of completion of construction of Layer 2A within 1-3 km from the rise crest and typical EPR half-spreading rates of 5-8 cm/yr suggest that the studied 400 m of ocean crust represents 37,000-60,000 years. The fast construction of EPR crust implies that the Middle Jurassic geomagnetic field was reversing at a phenomenal rate of 5000-10,000 years. These data establish that the `quiet' signature in the oldest portion of the lineated magnetic anomaly patterns in the ocean crust is due to exceedingly rapid reversals of the geomagnetic field, because succes-sive, superposed opposite-polarity magnetic signatures will essentially cancel one another out at the sea surface. The width of the 'quiet' magnetic signature in the western Pacific Ocean implies that the 5000

  2. Potent enhancement of transdermal absorption and stability of human tyrosinase plasmid (pAH7/Tyr) by Tat peptide and an entrapment in elastic cationic niosomes.

    PubMed

    Manosroi, Jiradej; Khositsuntiwong, Narinthorn; Manosroi, Worapaka; Götz, Friedrich; Werner, Rolf G; Manosroi, Aranya

    2013-01-01

    Enhancement of transdermal absorption through rat skin and stability of the human tyrosinase plasmid (P) using Tat (T) and an entrapment in elastic cationic niosomes (E) were described. E (Tween61:cholesterol:DDAB at 1:1:0.5 molar ratio) were prepared by the freeze-dried empty liposomes (FDELs) method using 25% ethanol. TP was prepared by a simple mixing method. TPE was prepared by loading T and P in E at the T:P:E ratio of 0.5:1:160 w/w/w. For gel formulations, P, TP, PE and TPE were incorporated into Carbopol 980 gel (30 µg of plasmid per 1 g of gel). For the transdermal absorption studies, the highest cumulative amounts and fluxes of the plasmid in viable epidermis and dermis (VED) were observed from the TPE of 0.31 ± 0.04 µg/cm(2) and 1.86 ± 0.24 µg/cm(2)/h (TPE solution); and 4.29 ± 0.40 µg/cm(2) and 25.73 ± 2.40 µg/cm(2)/h (TPE gel), respectively. Only plasmid from the PE and TPE could be found in the receiving solution with the cumulative amounts and fluxes at 6 h of 0.07 ± 0.01 µg/cm(2) and 0.40 ± 0.08 µg/cm(2)/h (PE solution); 0.10 ± 0.01 µg/cm(2) and 0.60 ± 0.06 µg/cm(2)/h (TPE solution); 0.88 ± 0.03 µg/cm(2) and 5.30 ± 0.15 µg/cm(2)/h (PE gel); and 1.02 ± 0.05 µg/cm(2) and 6.13 ± 0.28 µg/cm(2)/h (TPE gel), respectively. In stability studies, the plasmid still remained at 4 ± 2 °C and 25 ± 2 °C of about 48.00-65.20% and 27.40-51.10% (solution); and 12.34-38.31% and 8.63-36.10% (gel), respectively, whereas at 45 ± 2 °C, almost all the plasmid was degraded. These studies indicated the high potential application of Tat and an entrapment in elastic cationic niosomes for the development of transdermal gene delivery system.

  3. Morphological and functional preservation of pre-antral follicles after vitrification of macaque ovarian tissue in a closed system

    PubMed Central

    Ting, A. Y.; Yeoman, R. R.; Campos, J. R.; Lawson, M. S.; Mullen, S. F.; Fahy, G. M.; Zelinski, M. B.

    2013-01-01

    STUDY QUESTION What are the appropriate conditions to vitrify the macaque ovarian cortex in a large-volume, closed system that will preserve functional pre-antral follicles? SUMMARY ANSWER The combination of glycerol, ethylene glycol (EG) and polymers with cooling in liquid nitrogen (LN2) vapor and a two-step warming procedure was able to preserve tissue and follicle morphology as well as function of a small population of secondary follicles in the macaque ovarian cortex following vitrification in a closed system. WHAT IS KNOWN ALREADY For prepubertal cancer patients or those who require immediate cancer therapy, ovarian tissue cryopreservation offers the only hope for future fertility. However, the efficacy of live birth from the transplantation of cryopreserved ovarian tissue is still unclear. In addition, live birth from cryopreserved ovarian tissue has only been demonstrated after tissue autotransplantation, which poses the risk of transmitting metastatic cancer cells back to the cancer survivor in certain cancers. STUDY DESIGN, SIZE, DURATION Non-human primate model, n = 4, randomized, control versus treatment. End-points were collected from tissue histology, tissue culture (48 h) and isolated secondary follicle culture (6 weeks). PARTICIPANTS/MATERIALS, SETTING, METHODS Two vitrification solutions (VSs) containing EG + glycerol (VEG) and EG + dimethylsulfoxide (VED) were examined for vitrification, devitrification and thermodynamic properties. Once the optimal VS was determined, macaque ovarian cortical pieces (3 × 3 × 0.5 mm3) were divided into fresh and two vitrified groups (VEG and VED). For the vitrification groups, tissues were exposed to 1/4, 1/2 and 1× VS for 5 min/step as well as 1× VS + polymers for 1 min at 37°C, loaded into high-security straws with 1 ml of VS + polymers, heat sealed and cooled in LN2 vapor. Samples were warmed in a 40°C water bath and cryoprotective agents were diluted with 1, 0.5, 0.25 and 0 M sucrose. Tissues were fixed

  4. Podzol development in S Norway - a soil chronosequence of 31 pedons covering soil ages from 85 to 9650 years

    NASA Astrophysics Data System (ADS)

    Sauer, Daniela; Svendgård-Stokke, Siri; Sperstad, Ragnhild; Sørensen, Rolf; Fuchs, Markus; Gebers, Henrik; Schülli-Maurer, Isabelle

    2013-04-01

    horizons. The mineralogical composition of the parent material is dominated by quartz and feldspars, whereby the feldspar grains show features of proceeding weathering with time. In addition to podzolisation features, illuvial clay is observed below the Bs horizons. Apparently, the sand is sufficiently buffered during the first millennia of soil formation so that acidification proceeds slowly enough to allow for clay translocation prior to podzolisation. Reference Sørensen, R., Høeg, H.I., Henningsmoen, K.E., Skog, G., Labowsky, S.F., Stabell, B. (2012): Utviklingen av det senglasiale og tidlig preboreale landskapet og vegetasjonen omkring steinalderboplassene ved Pauler, Larvik kommune, Vestfold. In: Jaksland, L. (Ed.), E18 Brunlaneprospektet. Varia 79. Kulturhistorisk Museum, University of Oslo.

  5. Micromorphological changes over time observed in the Vestfold Podzol chronosequence, SE Norway

    NASA Astrophysics Data System (ADS)

    Sauer, Daniela; Musztyfaga, Elżbieta; Sørensen, Rolf; Svendgård-Stokke, Siri; Rennert, Thilo; Sperstad, Ragnhild; Fuchs, Markus

    2016-04-01

    addition, micromorphological analysis shows that clay translocation took place prior to strong acidification and podzolisation in many profiles. In some rare cases, clay coatings are observed even on top of spodic material, suggesting that - at least to minor extent - translocation of coarse clay may take place even contemporarily to podzolisation. This apparent contradiction can be explained by different depths of mobilisation of metal-organic complexes and clay. Apparently, even when the upper, strongly acid part of the soils is already subject to podzolisation, acidification and Al saturation at some depth are still not as advanced as further up in the profile and still allow for clay mobilisation. In addition, cappings of coarse clay and fine silt on top of larger grains suggest that water flushing through the coarse voids of the sandy material, e.g., after snow-melt, may sweep down also clay particles in a not completely dispersed state. In this way, clay translocation might take place also outside the pH range that is usually considered suitable for clay migration. Reference Sørensen, R., Høeg, H.I., Henningsmoen, K.E., Skog, G., Labowsky, S.F., Stabell, B., 2012. Utviklingen av det senglasiale og tidlig preboreale landskapet og vegetasjonen omkring steinalderboplassene ved Pauler, Larvik kommune, Vestfold. In: Jaksland, L. (Ed.), E18 Brunlaneprospektet. Varia 79. Kulturhistorisk Museum, University of Oslo.

  6. Offshore influence of coastal upwelling off Mauritania, NW Africa, as recorded by diatoms in sediment traps at 2195 m water depth

    NASA Astrophysics Data System (ADS)

    Lange, Carina B.; Romero, Oscar E.; Wefer, Gerold; Gabric, Albert J.

    1998-06-01

    taxa in the sediments. In an attempt to contrast coastal vs. oceanic upwelling, we compared the Cap Blanc trap results (a coastal/open-ocean transition site) with the patterns recorded previously in sediment traps from the Guinea Basin (GBN3; an open-ocean equatorial upwelling site). Enhanced fluxes at both sites corresponded in time with the occurrence of upwelling (i.e. spring and early summer for CB1, and early spring and summer for GBN3). Total, opal and lithogenic mean daily fluxes were 2.4, 1.6 and 6.3 times higher at CB1 than at GBN3. Diatom and silicoflagellate fluxes were 8.9 and 1.6 times higher at GBN3. On a yearly basis, the diatom flora for CB1 can be characterized as "coastal with oceanic influence", and for GBN3 as "open ocean with moderate coastal influence". Chain-forming and colonial diatoms with individual cell diameters of >5 μm dominated the coastal upwelling site ( Thalassionema nitzschioides and Chaetoceros), while small (<5 μm) solitary diatoms ( Nitzschia bicapitata) dominated the open ocean equatorial upwelling regime. Comparable relative abundances of freshwater diatoms were noted at both trap sites; their seasonal distribution within each geographical area was attributed to the Saharan dust transport patterns involved. While diatom indicators of coastal upwelling were readily preser ved in the surface sediments off Cap Blanc, the assemblage in the Guinea Basin sediments differed greatly from that in the traps with the summer signal for equatorial upwelling being removed from the sediment. We conclude that significant differences between the assemblages trapped at both sites support the usefulness of these data as sensitive indicators of dissimilar oceanographic settings.

  7. Anhydrobiosis vs. aging: comparative genomics of protein repair L-isoaspartyl methyltransferases in the sleeping chironomid. .

    NASA Astrophysics Data System (ADS)

    Gusev, Oleg; Kikawada, Takahiro; Shagimardanova, Elena; Suetsugu, Yoshitaka; Ayupov, Rustam

    and larval stages. Finally, the expression of Pimt1 gene in both chironomids was not changed in response to desiccation, while the clustered PvPimt2-12 showed strong up-regulation in response to water loss and other abiotic stresses. The abundance of PvPimt2-12 mRNAs was maximal in anhydrobiotic larvae, and it resembles the case of plant seeds where accumulation of PIMT provides additional protection for proteins during long dry storage. Predicted proteins of PvPimT2-12 contain conservative L-isoaspartyl methyltransferase functional domain. At the same time the length and structure of N- and C- terminals of the predicted proteins show significant variation, suggesting different substrate preferences or other specific properties of different Pv-PIMT Furthermore, the multi-member family in Pv is the first observation of drastic expansion and evolution of Pimt genes in general, and particularly in a single insect species. This work was supported by Russian Foundation for Basic Research (№ 12-08-33157 mol_a_ved and № 14-04-01657_A).

  8. Fluid composition and evolution in coesite-bearing rocks (Dora-Maira massif, Western Alps): implications for element recycling during subduction

    NASA Astrophysics Data System (ADS)

    Philippot, Pascal; Chevallier, Pierre; Chopin, Christian; Dubessy, Jean

    1995-08-01

    Fluid inclusions and F, Cl concentration of hydrous minerals were analysed in the coesite-pyrope quartzite, the interlayered jadeite quartzite and their country-rock gneiss from the Dora-Maira massif using a combination of microthermometry, Raman spectrometry, synchrotron X-ray microfiuorescence and electron microprobe analysis. Three populations of fluid inclusions were recognized texturally and can be related to distinct metamorphic stages. A low-salinity aqueous fluid occurs in the retrogressed country gneiss and as late secondary inclusions in jadeite quartzite and chloritized pyrope. An earlier secondary population is found in matrix quartz of the jadeite- and pyro-pe-quartzites. This population can be related to the early decompression and so to incipient breakdown of garnet into phlogopite-bearing assemblages. The inclusion fluid is highly saline (up to 84 wt% equivalent NaCl) and contains Na, Ca, Fe, Cu and Zn as major cations. In pyrope quartzite, additional K was found in these brines, which locally coexist with CO2-rich inclusions. The oldest fluid inclusions are preserved in kyanite grains included in fresh pyrope and in pyrope itself. In pyrope, all inclusions have decrepitated and contain magnesite, an Mg-phosphate, sheet-silicate(s), a chloride and an opaque phase, with no fluid preser ved. In contrast, the kyanite inclusions in pyrope preserve primary H2O-CO2 low-salinity fluid inclusions, probably owing to the low compressibility of the kyanite inclusions and host garnet. In spite of in-situ re-equilibration, these inclusions can be interpreted as relics of the dehydration fluid that attended pyrope growth. These correlations between textural and chemical fluid inclusion data and metamorphic stages are consistent with the fluid composition calculated from the halogen content of different generations of phlogopite and biotite. The preservation of different fluid compositions, both in time and space, is evidence for local control and possibly origin

  9. Investigations of the air flow velocity field structure above the wavy surface under severe wind conditions by particle image velosimetry technique.

    NASA Astrophysics Data System (ADS)

    Troitskaya, Yuliya; Kandaurov, Alexander; Sergeev, Daniil; Ermakova, Olga

    2013-04-01

    both method were in a good agreement. The application of PIV method enabled us measuring wind velocity profiles much closer to water surface than in the case of contact method. As a result there exists the logarithmic parts in velocity profiles, which yield turbulent momentum flux from the slope and also the equivalent 10-m wind speed and the surface drag coefficient. It was shown that similarly to [2] the surface drag coefficient tends to saturate at wind velocities exceeding 25 m/s. The decrease of the water surface drag coefficient with wind velocity increase was not observed. This work was supported by RFBR (project 11-05-12047-ofi-m, 13-05-00865-a, 12-05-33070 mol-a-ved, 12-05-31435 mol-a, 12-05-01064-a). References 1. Canny, J. A. Computational approach to edge detection/ J.A. Canny// IEEE Trans. Pattern Analysis and Machine Intelligence. - 1986. - V. 8(6). - P. 679-698.. 2. Troitskaya, Y. I., D. A. Sergeev, A. A. Kandaurov, G. A. Baidakov, M. A. Vdovin, and V. I. Kazakov Laboratory and theoretical modeling of air-sea momentum transfer under severe wind conditions J.Geophys. Res., 117, C00J21, doi:10.1029/2011JC007778.

  10. Objectives and Outcomes

    SciTech Connect

    Segalman, D.J.

    1998-11-30

    I have recently become involved in the ABET certification process under the new system - ABET 2000. This system relies heavily on concepts of Total Quality Management (TQM). It encourages each institution to define its objectives in terms of its own mission and then create a coherent program based on it. The prescribed steps in setting up the new system at an engineering institution are: o identification of constituencies G definition of mission. It is expected that the department's mission will be consistent with that of the overall institution, but containing some higher resolution language appropriate to that particular discipline of the engineering profession. o statement of objectives consistent with the mission 3G~~\\vED " enumeration of desired, and preferably measurable, outcomes of the process that would ~ `=. verify satisfaction of the objectives. ~~~ 07 !398 o establish performance standards for each outcome. o creation of appropriate feedback loops to assure that the objectives are still consistent with Q$YT1 the mission, that the outcomes remain consistent with the objectives, and that the curriculum and the teaching result in those outcomes. It is my assertion that once the institution verbalizes a mission, enumerated objectives naturally flow from that mission. (We shall try to demonstrate by example.) Further, if the mission uses the word "engineer", one would expect that word also to appear in at least one of the objectives. The objective of producing engineers of any sort must -by decree - involve the presence of the ABET criteria in the outcomes list. In other words, successful satisfaction of the ABET items a-k are a necessary subset of the measure of success in producing engineers. o We shall produce bachelor level engineers whose training in the core topics of chemical (or electrical, or mechanical) engineering is recognized to be among the best in the nation. o We shall provide an opportunity for our students to gain a

  11. [Macular choroidal blood flow in concurrent age-related macular degeneration and primary open-angle glaucoma].

    PubMed

    Panova, I E; Ermak, E M; Shaimova, T A; Shaimova, V A

    2016-01-01

    олическая скорость (peak systolic velocity — Vps), конечная диастолическая скорость (end-diastolic velocity — Ved), усредненная по времени максимальная скорость кровотока (time-averaged maximum velocity — Vtamax), индекс резистентности (resistive index — RI). Результаты. Установлено, что в 1-й, 3-й группах и подгруппе 2А формируется гипоперфузионный тип хориоидального кровотока в макулярной зоне (снижение Vtamax) с развитием некомпенсированного перфузионного дефицита на фоне напряжения механизмов ауторегуляции (снижение Vps, Ved, сниженные или нормальные значения RI). У больных подгруппы 2Б достоверно чаще формируется гиперперфузионный тип хориоидального кровотока (повышение Vps, Ved, Vtamax, RI). Заключение. Сочетанная патология — ВМД и ПОУГ — характеризуется гипоперфузионным типом хориоидального кровотока в макулярной зоне, что приводит к нарушению трофики нейросенсорной сетчатки и предопределяет возможность утяжеления течения ВМД с прогрессированием атрофической формы.