Meunier, N.; Lafon, M.; Maeght, P.; Grimaud, F.; Roudier, Th.
I will review the history and status of the data archive BASS2000 and will concentrate my presentation on the BASS2000-Tarbes data base, which contains a very large volume of THEMIS data, i.e. spectropolarimetric data. I will insist the implementation of the processing of MTR-THEMIS (multi-line spectropolarimetry) data by the BASS2000 team, which has been our main project in 2006. New data levels are Stokes profiles and clean spectra, maps of continuum intensity and line-center intensity, Dopplergrams, magnetograms and vector magnetic field maps. I will also present the tools and services that we are providing.
Aibar Solana, Alberto; Bois, Julien E.; Zaragoza, Javier; Bru, Noëlle; Paillard, Thierry; Generelo, Eduardo
Purpose: The aim of this study was to determine and compare the correlates of objective sedentary behavior (SB) and nonschool self-reported SB in adolescents from 2 midsized cities, 1 in France (Tarbes) and 1 in Spain (Huesca). Stability of objective SB and nonschool self-reported SB were also assessed at different time points during 1 academic…
Herpes simplex virus g134.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin...Invest 2002;109:871–82. Kuruppu D, Tanabe KK. Viral oncolysis by herpes simplex virus and other viruses. Cancer Biology & Therapy. 2005; 4(5...524-31 Kuruppu D, Brownell A, Zhu A, Yu M, Wang X, Kulu Y, Fuchs B, Kawasaki H, Tanabe KK. Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Research. 2007; 67(7): 3295.
Pétrus, M; Bonaz, S; Causse, E; Micheau, P; Rhabbour, M; Netter, J C; Bildstein, G
The authors report a sery of 16 cases of intolerance to the benzoates in children. Sixteen children (9 boys and 7 girls) were directed to the Hospital of Tarbes from June 1995 to July 1995, for recurring urticaria (7/16) combined with asthma (1/16), atopic eczema (2/16), dermorespiratory syndrome (2/16) and asthma (1/16). All were subject to an immunological examination comprising alimentation inquiry, prick test, IgE determination, RAST, oral provocation test to benzoates, which establishes the diagnosis, whose confirmation is certified by the benefit of the food eviction. To conclusion, the authors underline several points: the presumable underestimation of the intolerance, the often mentioned atopic familial context, the observed pathology (urticaria, asthma, eczema), the importance of the provocation test. Finally, besides food such as grey shrimps, sodas and antibiotic syrups, one finds benzoates in the antiallergic syrups initially prescribed as a preventive measure.
Shams, Qamar A.; Zuckerwar, Allan J.; Sullivan, Nicholas T.; Knight, Howard K.
Sensor technologies can make a significant impact on the detection of aircraft-generated vortices in an air space of interest, typically in the approach or departure corridor. Current state-of-the art sensor technologies do not provide three-dimensional measurements needed for an operational system or even for wake vortex modeling to advance the understanding of vortex behavior. Most wake vortex sensor systems used today have been developed only for research applications and lack the reliability needed for continuous operation. The main challenges for the development of an operational sensor system are reliability, all-weather operation, and spatial coverage. Such a sensor has been sought for a period of last forty years. Acoustic sensors were first proposed and tested by National Oceanic and Atmospheric Administration (NOAA) early in 1970s for tracking wake vortices but these acoustic sensors suffered from high levels of ambient noise. Over a period of the last fifteen years, there has been renewed interest in studying noise generated by aircraft wake vortices, both numerically and experimentally. The German Aerospace Center (DLR) was the first to propose the application of a phased microphone array for the investigation of the noise sources of wake vortices. The concept was first demonstrated at Berlins Airport Schoenefeld in 2000. A second test was conducted in Tarbes, France, in 2002, where phased microphone arrays were applied to study the wake vortex noise of an Airbus 340. Similarly, microphone phased arrays and other opto-acoustic microphones were evaluated in a field test at the Denver International Airport in 2003. For the Tarbes and Denver tests, the wake trajectories of phased microphone arrays and lidar were compared as these were installed side by side. Due to a built-in pressure equalization vent these microphones were not suitable for capturing acoustic noise below 20 Hz. Our group at NASA Langley Research Center developed and installed an
Manzoor, Maleeha; Anwar, Farooq; Saari, Nazamid; Ashraf, Muhammad
Variations of phenolics, antioxidant activity, and mineral contents in peel and pulp of five apple (Malus domestica Borkh.) cultivars from Pakistan, namely Red Delicious, Golden Delicious, Kashmiri Amri, Kala Kulu and Sky Spur were appraised. The mean extract yield of antioxidant components obtained with 80:20 methanol-water (v/v), was found to be 22.1 g/100 g for peel and 14.2 g/100 g for pulp on a dry weight basis. The amounts of total phenolics and total flavonoids in peel and pulp of different cultivars of apple ranged from 1,907.5-2,587.9 mg gallic acid equivalent/100 g DW and 1,214.3-1,816.4 mg catechin equivalent/100 g DW and 1,185.2-1,475.5 mg GAE/100 g DW and 711.8-999.3 mg CE/100 g DW, respectively. The inhibition of linoleic acid peroxidation and DPPH scavenging activity of the extracts varied from 71.7-84.9 and 66.6-80.8% in peel, and 43.9-52.8 and 42.9-51.1% in pulp, respectively. Reducing power of the tested fruit part extracts at concentration 12.5 mg/mL ranged from 2.54-2.89 and 1.37-1.73, respectively. With regard to minerals analysis, both fruit parts showed the amount of K to be the highest, followed by Mg, Ca, Fe, Na and Zn. The results revealed that peel of the tested apple cultivars in this study had superior antioxidant capacity and mineral concentration than the pulp, indicating significant variations between the parts tested. Thus, consumption of apple fruits along with peel might be recommended to gaining better nutritive benefits.
Hermida, Lucía; Sánchez, José Luis; López, Laura; Berthet, Claude; Dessens, Jean; García-Ortega, Eduardo; Merino, Andrés
Hail precipitation is characterized by enhanced spatial and temporal variability. Association Nationale d'Etude et de Lutte contre les Fléaux Atmosphériques (ANELFA) installed hailpad networks in the Atlantic and Midi-Pyrénées regions of France. Historical data of hail variables from 1990 to 2010 were used to characterize variability. A total of 443 stations with continuous records were chosen to obtain a first approximation of areas most affected by hail. The Cressman method was selected for this purpose. It was possible to find relationships between spatial distributions of the variables, which are supported by obtained Pearson correlations. Monthly and annual trends were examined using the Mann-Kendall test for each of the total affected hailpads. There were 154 pads with a positive trend; most were located between Tarbes and Saint-Gaudens. We found 177 pads with a negative trend, which were largely south of a pine forest in Landes. The remainder of the study area showed an elevated spatial variability with no pattern, even between relatively close hailpads. A similar pattern was found in Lérida (Spain) and Southeast France. In the entire area, monthly trends were predominantly negative in June, July, and August, whereas May had a positive trend; again, however, there was no spatial pattern. There was a high concentration of hailpads with positive trend near the Pyrenees, probably owing to orographic effects, and if we apply cluster analysis with the Mann-Kendall values, the spatial variability is accentuated for stations at higher altitude. PMID:24307872
In 2009, the Centre National d'Etudes Spatiales (CNES) carried out an assessment study on a "Fresnel telescope" concept based on a two-spacecraftformation flying configuration. This concept uses a binary Fresnel zone plate, and the principle of diffraction focusing, which allows high resolution optical imaging for astrophysics. In addition to CNES, the Laboratoire d'Astrophysique de Toulouse Tarbes (LATT) was deeply involved at two levels: through Research & Technology (R&T) studies to simulate and validate on a test bench the Fresnel concept performance, and through active participation in the CNES team for the optical aspects and to define the astrophysical fields of Fresnel-based space missions. The study was conducted within the technical limitations that resulted from a compromise between the R&T state of the art and the potential scientific domains of interest. The main technical limitations are linked to the size of the primary Fresnel array and to its usable spectral bandwidth. In this framework, the study covers ambitious architectures, correlating the technology readiness of the main critical components with the time-scale and programmatic horizons. The possible scientific topics arise from this range of missions. In this paper, I present a mission launched by a Soyuz, dedicated to astrophysics in the Ultra Violet (UV) band: 120 to 300 nm using a 4-m Fresnel array. It could be competitive in the next fifteen years, whereas a 10-m aperture mission in different bands; UV, visible or Infra Red (IR) (up to 6 μm) could be achievable in the future. Larger missions, using a primary array larger than 20 m, request technologies not yet available but that will probably be based on new inflatable structures with membranes, as already tested in the USA for other ends.
Kobayashi, Makoto; Matsumoto, Toshihide; Ryuge, Shinichiro; Yanagita, Kengo; Nagashio, Ryo; Kawakami, Yoshitaka; Goshima, Naoki; Jiang, Shi-Xu; Saegusa, Makoto; Iyoda, Akira; Satoh, Yukitoshi; Masuda, Noriyuki; Sato, Yuichi
To develop sero-diagnostic markers for lung cancer, we generated monoclonal antibodies using pulmonary adenocarcinoma (AD)-derived A549 cells as antigens by employing the random immunization method. Hybridoma supernatants were immunohistochemically screened for antibodies with AMeX-fixed and paraffin-embedded A549 cell preparations. Positive clones were monocloned twice through limiting dilutions. From the obtained monoclonal antibodies, we selected an antibody designated as KU-Lu-5 which showed intense membrane staining of A549 cells. Based on immunoprecipitation and MADLI TOF/TOF-MS analysis, this antibody was recognized as carbonic anhydrase XII (CAXII). To evaluate the utility of this antibody as a sero-diagnostic marker for lung cancer, we performed dot blot analysis with a training set consisting of sera from 70 lung cancer patients and 30 healthy controls. The CAXII expression levels were significantly higher in lung cancer patients than in healthy controls in the training set (P<0.0001), and the area under the curve of ROC was 0.794, with 70.0% specificity and 82.9% sensitivity. In lung cancers, expression levels of CAXII were significantly higher in patients with squamous cell carcinoma (SCC) than with AD (P = 0.035). Furthermore, CAXII was significantly higher in well- and moderately differentiated SCCs than in poorly differentiated ones (P = 0.027). To further confirm the utility of serum CAXII levels as a sero-diagnostic marker, an additional set consisting of sera from 26 lung cancer patients and 30 healthy controls was also investigated by dot blot analysis as a validation study. Serum CAXII levels were also significantly higher in lung cancer patients than in healthy controls in the validation set (P = 0.030). Thus, the serum CAXII levels should be applicable markers discriminating lung cancer patients from healthy controls. To our knowledge, this is the first report providing evidence that CAXII may be a novel sero-diagnostic marker for
Zhang, Jiapu; Zhang, Yuanli
Prion diseases, traditionally referred to as transmissible spongiform encephalopathies (TSEs), are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species, manifesting as scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad-cow disease) in cattle, chronic wasting disease in deer and elk, and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and kulu in humans, etc. These neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (PrP(C)) into insoluble abnormally folded infectious prions (PrP(Sc)), and the conversion of PrP(C) to PrP(Sc) is believed to involve conformational change from a predominantly α-helical protein to one rich in β-sheet structure. Such a conformational change may be amenable to study by molecular dynamics (MD) techniques. For rabbits, classical studies show that they have a low susceptibility to be infected by PrP(Sc), but recently it was reported that rabbit prions can be generated through saPMCA (serial automated Protein Misfolding Cyclic Amplification) in vitro and the rabbit prion is infectious and transmissible. In this paper, we first do a detailed survey on the research advances of rabbit prion protein (RaPrP) and then we perform MD simulations on the NMR and X-ray molecular structures of rabbit prion protein wild-type and mutants. The survey shows to us that rabbits were not challenged directly in vivo with other known prion strains and the saPMCA result did not pass the test of the known BSE strain of cattle. Thus, we might still look rabbits as a prion resistant species. MD results indicate that the three α-helices of the wild-type are stable under the neutral pH environment (but under low pH environment the three α-helices have been unfolded into β-sheets), and the three α-helices of the mutants (I214V and S173N) are unfolded into rich β-sheet structures under
Borges de Araújo, Camila Guedes; Oliveira do Nascimento Holanda, Aldenora; de Souza Rocha, Cinthya Vivianne; Soares do Nascimento, Ayla Patricia; Simplício Revoredo, Camila Maria; Borges da Silva, Benedito; do Nascimento Nogueira, Nadir; do Nascimento Marreiro, Dilina
Introducción: diversos estudios muestran alteraciones en el metabolismo del zinc en mujeres con cáncer de mama. Este mineral posee acción antioxidante, y los disturbios en sus parámetros bioquímicos están relacionados con peor pronóstico de la enfermedad y agravamiento del proceso carcinogénico. Objetivos: este estudio evaluó la actividad de la enzima superóxido dismutasa y los parámetros bioquímicos relativos al zinc e investigó la existencia de correlación entre esas variables y el marcador del estrés oxidativo en estas pacientes. Métodos: este fue un estudio caso-control con 66 mujeres, con edad ente 20 y 50 años, distribuidas en: grupo caso (mujeres con cáncer de mama, n = 34) y grupo control (mujeres saludables, n = 32). La ingestión del zinc fue realizada por medio del registro alimentario de tres días, utilizando el programa Nutwin versión 1.5. Las concentraciones de zinc plasmático y eritrocitario fueron determinadas según el método de espectrofotometría de absorción atómica de llama (λ = 213,9). La actividad de la superóxido dismutasa fue evaluada por el método colorimétrico de Griess y fueron analizadas sustancias reactivas al ácido tiobarbitúrico (TBARS). Resultados y discusión: los valores medios de la ingestión de zinc, superóxido dismutasa y TARBS eran superiores a los recomendados para las participantes del estudio, con una diferencia estadística para la enzima superóxido dismutasa (p > 0,05). La media de las concentraciones plasmática y eritrocitaria de zinc fueron reducidos en ambos grupos (p > 0.05). Conclusiones: por lo tanto, se puede suponer que la ingesta de zinc en mujeres con cáncer de mama no influye en las concentraciones plasmáticas y eritrocitarias de ese mineral. La elevada actividad de la superóxido dismutasa en las mujeres con cáncer de mama puede ser debida a un mecanismo de regulación compensatorio mediante el estrés oxidativo presente en esa enfermedad.
Tafferner, A.; Birke, L.; Frech, M.
A central task of the ongoing DLR project "Wirbelschleppe" (Wake Vortex) is to forecast meteorological quantities which influence the behaviour of wake vortices of landing aircraft. In the first place these are wind, temperature and turbulence, resp. the vertical shear thereof, which impact the lateral drift and turbulent decay of wake vortices. For this purpose the nowcasting system NOWVIV has been developed at DLR. It combines operational forecasts of the Lokal Modell (LM; Doms and Schaettler 1999) of the German weather service DWD with a high-resolution forecasting system. For the latter, the NOAA/FSL version of the mesoscale model MM5 (Grell et al. 2000) has been adapted to particular sites. Orography, land use, and soil type have been generated from available data sources for a 80 km square domain centered on a particular airport with a horizontal resolution of 2.1 km. As a good representation of the boundary layer is of particular importance for predicting wake vortex impact variables, the vertical spacing of model layers has been selected rather small throughout the lower model atmosphere, starting with 20 m at the ground and increasing to about 60 m at 2 km height. NOWVIV delivers vertical profiles of vortex impact variables, which are used by the wake prediction model ``P2P'' developed at DLR (Holzaepfel 2002) to predict wake vortex behaviour. During the two field campaigns ``WakeOP'' and ``WakeTOUL'' in April/May 2001 and May/June 2002 which aimed at measuring (by lidar) and predicting wake vortex behaviour of landing aircraft, NOWVIV has been run in an operational mode for the airports of Oberpfaffenhofen (Germany) and Tarbes (France). A statistical evaluation of the NOWVIV forecasting performance during these campaigns achieved satisfactory results as compared to local measurements of wind and temperature from radio acoustic sounding instruments (Frech et al. 2002). However, there are uncertainties in the daily variation of the boundary layer. Also, the
). A preprint is available here and also as astro-ph0409323. Notes : This press release is issued simultaneously by ESO and CNRS (in French). : The team consists of Gael Chauvin and Christophe Dumas (ESO-Chile), Anne-Marie Lagrange and Jean-Luc Beuzit (LAOG, Grenoble, France), Benjamin Zuckerman and Inseok Song (UCLA, Los Angeles, USA), David Mouillet (LAOMP, Tarbes, France) and Patrick Lowrance (IPAC, Pasadena, USA). The American members of the team acknowledge funding in part by NASA's Astrobiology Institute. : The NACO facility (from NAOS/Nasmyth Adaptive Optics System and CONICA/Near-Infrared Imager and Spectrograph) at the 8.2-m VLT Yepun telescope on Paranal offers the capability to produce diffraction-limited near-infrared images of astronomical objects. It senses the radiation in this wavelength region with the N90C10 dichroic; 90 percent of the flux is transmitted to the wavefront sensor and 10 percent to the near-infrared camera CONICA. This mode is particularly useful for sharp imaging of red and very-low-mass stellar or substellar objects. The adaptive optics corrector (NAOS) was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA), Laboratoire d'Astrophysique de Grenoble (LAOG) and the LESIA and GEPI laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. : What is the difference between a small brown dwarf and an exoplanet ? The border line between the two is still being investigated but it appears that a brown dwarf object is formed in the same way as stars, i.e. by contraction in an interstellar cloud while planets are formed within stable circumstellar disks via collision/accretion of planetesimals or disk instabilities. This implies that brown