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Sample records for kulu riho tarbe

  1. BASS2000-Tarbes: current status and THEMIS data processing .

    NASA Astrophysics Data System (ADS)

    Meunier, N.; Lafon, M.; Maeght, P.; Grimaud, F.; Roudier, Th.

    I will review the history and status of the data archive BASS2000 and will concentrate my presentation on the BASS2000-Tarbes data base, which contains a very large volume of THEMIS data, i.e. spectropolarimetric data. I will insist the implementation of the processing of MTR-THEMIS (multi-line spectropolarimetry) data by the BASS2000 team, which has been our main project in 2006. New data levels are Stokes profiles and clean spectra, maps of continuum intensity and line-center intensity, Dopplergrams, magnetograms and vector magnetic field maps. I will also present the tools and services that we are providing.

  2. Anthropogenically accelerated mass movement, Kulu Valley, Himachal Pradesh, India

    NASA Astrophysics Data System (ADS)

    Sah, M. P.; Mazari, R. K.

    1998-12-01

    A devastating landslide occurred on 12 September 1995 near Luggar Bhatti, Kulu, Himachal Pradesh, and killed 65 people. An estimated 0.96×10 6 m 3 of unconsolidated mass slid SSE down the terminal part of a thick alluvial fan of Quaternary age on the left bank of the Beas River. About 0.03×10 6 m 3 of dislodged material formed a 15-m high and 150-m long hump at the bottom of the failed slope; a shallow sag pond developed in the rear. The slide occurred after heavy rains on 3-6 September in the region when the Beas rose to a bankfull position. Factors involved in this toppling-cum-debris slide include steep slope, continuous seepage with high pore water pressure in unconsolidated material, a road-cut obliterating the foot of the fan slope, and impinging by the Beas River during the flood. A survey in the area showed that a variety of mass movement processes were triggered by the heavy rains in September; the most predominant being a series of slope failures on the outside of meander loops and bank erosion caused by turbulence of the overflowing Beas River. Extensive damage was sustained by National Highway-21 (NH-21), a bridge ramp near Bhuntar, a suspension bridge at Kulu and two other bridges upstream. Most damage occurred in the Manali area where massive buildings were washed away by the flash flood. This paper examines the factors and processes responsible for triggering widespread mass movement and related damages in the Kulu Valley. Whereas some smaller events occurred in the early and middle part of this century, the recurrence and intensity of mass movements are recent phenomena attributed mainly to escalating socio-economic development, growth of tourism, and population pressure. Some long term policy is suggested for mitigation of landslides and other denudational processes in relation to impelling human factors.

  3. Introduction to the XV International Symposium on Very High Energy Cosmic Ray Interactions

    NASA Astrophysics Data System (ADS)

    Jones, Lawrence W.

    2009-12-01

    A brief history of this conference series is noted, with particular reference to the most recent meeting in Weihai, China in 2006 and the meeting in Tarbes in 1990. The historically relevant emulsion chamber results are recalled, and the promise of the CERN Large Hadron Collider experiments in this area of physics is discussed.

  4. Adolescents' Sedentary Behaviors in Two European Cities

    ERIC Educational Resources Information Center

    Aibar Solana, Alberto; Bois, Julien E.; Zaragoza, Javier; Bru, Noëlle; Paillard, Thierry; Generelo, Eduardo

    2015-01-01

    Purpose: The aim of this study was to determine and compare the correlates of objective sedentary behavior (SB) and nonschool self-reported SB in adolescents from 2 midsized cities, 1 in France (Tarbes) and 1 in Spain (Huesca). Stability of objective SB and nonschool self-reported SB were also assessed at different time points during 1 academic…

  5. A Compilation of Moored Instrument Data and Associated Oceanographic Observations. Volume XXX. Gulf Stream Extension and Norwegian Sea Overflow Intrusion Experiments, 1979 - 1980.

    DTIC Science & Technology

    1982-10-01

    XXX (GULF STREAM EXTENSION AND -NORWEGIAN SEA OVERFLOW INTRUSION CA EXPERIMENTS) 1979 - 1980 by Ellen Levy, Susan A. Tarbe~l’ and. 3October 1982...MOORED INSTRUMENT DATA AND ASSOCIATED OCEANOGRAPHIC OBSERVATIONS, VOLUME Technical XXX (GULF STREAM EXTENSION AND NORWEGIAN SEA 6. PERFORMING ORG...8217 WHOI-82-43 A COMPILATION OF MOORED INSTRUMENT DATA AND ASSOCIATED OCEANOGPAPHIC OBSERVATIONS, VOLUME XXX (GULF STREAM

  6. Adolescents' Sedentary Behaviors in Two European Cities

    ERIC Educational Resources Information Center

    Aibar Solana, Alberto; Bois, Julien E.; Zaragoza, Javier; Bru, Noëlle; Paillard, Thierry; Generelo, Eduardo

    2015-01-01

    Purpose: The aim of this study was to determine and compare the correlates of objective sedentary behavior (SB) and nonschool self-reported SB in adolescents from 2 midsized cities, 1 in France (Tarbes) and 1 in Spain (Huesca). Stability of objective SB and nonschool self-reported SB were also assessed at different time points during 1 academic…

  7. Viral Oncolytic Therapeutics for Neoplastic Meningitis

    DTIC Science & Technology

    2012-07-01

    Herpes simplex virus g134.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin...Invest 2002;109:871–82. Kuruppu D, Tanabe KK. Viral oncolysis by herpes simplex virus and other viruses. Cancer Biology & Therapy. 2005; 4(5...524-31 Kuruppu D, Brownell A, Zhu A, Yu M, Wang X, Kulu Y, Fuchs B, Kawasaki H, Tanabe KK. Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Research. 2007; 67(7): 3295.

  8. [Clinico-immunological study of 16 cases of benzoate intolerance in children].

    PubMed

    Pétrus, M; Bonaz, S; Causse, E; Micheau, P; Rhabbour, M; Netter, J C; Bildstein, G

    1997-02-01

    The authors report a sery of 16 cases of intolerance to the benzoates in children. Sixteen children (9 boys and 7 girls) were directed to the Hospital of Tarbes from June 1995 to July 1995, for recurring urticaria (7/16) combined with asthma (1/16), atopic eczema (2/16), dermorespiratory syndrome (2/16) and asthma (1/16). All were subject to an immunological examination comprising alimentation inquiry, prick test, IgE determination, RAST, oral provocation test to benzoates, which establishes the diagnosis, whose confirmation is certified by the benefit of the food eviction. To conclusion, the authors underline several points: the presumable underestimation of the intolerance, the often mentioned atopic familial context, the observed pathology (urticaria, asthma, eczema), the importance of the provocation test. Finally, besides food such as grey shrimps, sodas and antibiotic syrups, one finds benzoates in the antiallergic syrups initially prescribed as a preventive measure.

  9. Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136).

    PubMed

    Zhang, Jiapu; Zhang, Yuanli

    2013-06-01

    Prion diseases, traditionally referred to as transmissible spongiform encephalopathies, are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species, manifesting as scrapie in sheep, bovine spongiform encephalopathy (or 'mad-cow' disease) in cattle, and Creutzfeldt-Jakob disease, Gerstmann-Strussler-Scheinker syndrome, fatal familial insomnia (FFI), and Kulu in humans, etc. These neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (PrP(C)) into insoluble abnormally folded infectious prions (PrP(Sc)). The hydrophobic region PrP(109-136) controls the formation of diseased prions: the normal PrP(113-120) AGAAAAGA palindrome is an inhibitor/blocker of prion diseases and the highly conserved glycine-xxx-glycine motif PrP(119-131) can inhibit the formation of infectious prion proteins in cells. This article gives detailed reviews on the PrP(109-136) region and presents the studies of its three-dimensional structures and structural dynamics.

  10. Geodetic observations of accelerating ice loss in Greenland

    NASA Astrophysics Data System (ADS)

    Bevis, M. G.; Khan, S. A.; Brown, A. K.; Kendrick, E. C.; Wahr, J. M.; Knudsen, P.; Willis, M. J.; van Dam, T. M.

    2012-12-01

    The long-lived CGPS stations established in Kellyville (KELY), Kulusuk (KULU) and Thule (THU1/2/3) in the 1990's have all recorded large accelerations in the vertical displacement of the earth's crust from the mid-1990's to the present day. Since PGR proceeds at an effectively constant rate at the decadal timescale, these accelerations must manifest earth's instantaneous response to accelerations in ice loss. Since the deployment of the Greenland GPS Network (GNET), which took place in 2007-2009, bedrock motion is being measured at ~ 50 GPS stations located near the margins of the Greenland Ice Sheet. A great many of the GNET stations recorded a pulse of enhanced uplift during the record-breaking summer of 2010. In this presentation we show that many of these stations are recording more sustained accelerations. That is, at many GNET stations, especially in South Greenland, the rate of uplift since early 2010 is much greater than the rate of uplift observed from 2007 to early 2010. Thus the enhanced ice loss observed in the unusually hot and prolonged summer of 2010, was part of a longer-term acceleration in ice loss. We show how this conclusion is confirmed by concurrent accelerations in the horizontal components of crustal displacement.

  11. Wake Vortex Detection: Phased Microphone vs. Linear Infrasonic Array

    NASA Technical Reports Server (NTRS)

    Shams, Qamar A.; Zuckerwar, Allan J.; Sullivan, Nicholas T.; Knight, Howard K.

    2014-01-01

    Sensor technologies can make a significant impact on the detection of aircraft-generated vortices in an air space of interest, typically in the approach or departure corridor. Current state-of-the art sensor technologies do not provide three-dimensional measurements needed for an operational system or even for wake vortex modeling to advance the understanding of vortex behavior. Most wake vortex sensor systems used today have been developed only for research applications and lack the reliability needed for continuous operation. The main challenges for the development of an operational sensor system are reliability, all-weather operation, and spatial coverage. Such a sensor has been sought for a period of last forty years. Acoustic sensors were first proposed and tested by National Oceanic and Atmospheric Administration (NOAA) early in 1970s for tracking wake vortices but these acoustic sensors suffered from high levels of ambient noise. Over a period of the last fifteen years, there has been renewed interest in studying noise generated by aircraft wake vortices, both numerically and experimentally. The German Aerospace Center (DLR) was the first to propose the application of a phased microphone array for the investigation of the noise sources of wake vortices. The concept was first demonstrated at Berlins Airport Schoenefeld in 2000. A second test was conducted in Tarbes, France, in 2002, where phased microphone arrays were applied to study the wake vortex noise of an Airbus 340. Similarly, microphone phased arrays and other opto-acoustic microphones were evaluated in a field test at the Denver International Airport in 2003. For the Tarbes and Denver tests, the wake trajectories of phased microphone arrays and lidar were compared as these were installed side by side. Due to a built-in pressure equalization vent these microphones were not suitable for capturing acoustic noise below 20 Hz. Our group at NASA Langley Research Center developed and installed an

  12. Variations of antioxidant characteristics and mineral contents in pulp and peel of different apple (Malus domestica Borkh.) cultivars from Pakistan.

    PubMed

    Manzoor, Maleeha; Anwar, Farooq; Saari, Nazamid; Ashraf, Muhammad

    2012-01-04

    Variations of phenolics, antioxidant activity, and mineral contents in peel and pulp of five apple (Malus domestica Borkh.) cultivars from Pakistan, namely Red Delicious, Golden Delicious, Kashmiri Amri, Kala Kulu and Sky Spur were appraised. The mean extract yield of antioxidant components obtained with 80:20 methanol-water (v/v), was found to be 22.1 g/100 g for peel and 14.2 g/100 g for pulp on a dry weight basis. The amounts of total phenolics and total flavonoids in peel and pulp of different cultivars of apple ranged from 1,907.5-2,587.9 mg gallic acid equivalent/100 g DW and 1,214.3-1,816.4 mg catechin equivalent/100 g DW and 1,185.2-1,475.5 mg GAE/100 g DW and 711.8-999.3 mg CE/100 g DW, respectively. The inhibition of linoleic acid peroxidation and DPPH scavenging activity of the extracts varied from 71.7-84.9 and 66.6-80.8% in peel, and 43.9-52.8 and 42.9-51.1% in pulp, respectively. Reducing power of the tested fruit part extracts at concentration 12.5 mg/mL ranged from 2.54-2.89 and 1.37-1.73, respectively. With regard to minerals analysis, both fruit parts showed the amount of K to be the highest, followed by Mg, Ca, Fe, Na and Zn. The results revealed that peel of the tested apple cultivars in this study had superior antioxidant capacity and mineral concentration than the pulp, indicating significant variations between the parts tested. Thus, consumption of apple fruits along with peel might be recommended to gaining better nutritive benefits.

  13. A space Fresnel imager concept assessment study led by CNES for astrophysical applications

    NASA Astrophysics Data System (ADS)

    Hinglais, Emmanuel

    2011-06-01

    In 2009, the Centre National d'Etudes Spatiales (CNES) carried out an assessment study on a "Fresnel telescope" concept based on a two-spacecraftformation flying configuration. This concept uses a binary Fresnel zone plate, and the principle of diffraction focusing, which allows high resolution optical imaging for astrophysics. In addition to CNES, the Laboratoire d'Astrophysique de Toulouse Tarbes (LATT) was deeply involved at two levels: through Research & Technology (R&T) studies to simulate and validate on a test bench the Fresnel concept performance, and through active participation in the CNES team for the optical aspects and to define the astrophysical fields of Fresnel-based space missions. The study was conducted within the technical limitations that resulted from a compromise between the R&T state of the art and the potential scientific domains of interest. The main technical limitations are linked to the size of the primary Fresnel array and to its usable spectral bandwidth. In this framework, the study covers ambitious architectures, correlating the technology readiness of the main critical components with the time-scale and programmatic horizons. The possible scientific topics arise from this range of missions. In this paper, I present a mission launched by a Soyuz, dedicated to astrophysics in the Ultra Violet (UV) band: 120 to 300 nm using a 4-m Fresnel array. It could be competitive in the next fifteen years, whereas a 10-m aperture mission in different bands; UV, visible or Infra Red (IR) (up to 6 μm) could be achievable in the future. Larger missions, using a primary array larger than 20 m, request technologies not yet available but that will probably be based on new inflatable structures with membranes, as already tested in the USA for other ends.

  14. Coronagraphy at Pic du Midi: Present state and future projects

    NASA Astrophysics Data System (ADS)

    Koechlin, L.

    2012-12-01

    The Pic du Midi coronagraph (CLIMSO) is a group of four instruments in parallel, taking images of the whole solar photosphere and low corona. It provides series of 2048*2048 pixels images taken nominally at 1 minute time intervals, all year long, weather permitting. A team of ≃q 60 persons, by groups of 2 or 3 each week, operate the instruments. Their work is programmed in collaboration with Institut de Recherches en astrophysique et planétologie (IRAP) of Observatoire Midi Pyrénées (OMP), and with Programme National Soleil Terre (PNST). The four instruments of CLIMSO (L1, C1, L2 and C2) collect images of the Sun as following: 1) L1 : photosphere in H-α (656.28 nm) ; 2) L2 : photosphere in Ca-II (393.37 nm) ; 3) C1 : prominences in H-α ; 4) C2 : prominences in He-I (1083.0 nm). The data taken are stored in fits format images and mpeg films. They are available publicly on data bases such as BASS 2000 Meudon ({http://bass2000.obspm.fr/home.php?lang=en} and BASS2000 Tarbes ({http://bass2000.bagn.obs-mip.fr/base/sun/index.php}). Several solar studies are carried in relation with these data. In addition to the raw fits images, new images will soon be sent to the data bases: they will be calibrated in solar surface emittance, expressed in W/m^2/nm/steradian. Series of mpeg films for each day are presented in superposed color layers, so as to visualize the multispectral information better. New instrumental developments are planned for the next years and already financed. They will use spectropolarimetry to measure the magnetic field and radial velocities in the photosphere and corona. The data will cover the entire solar disc and have a sample rate of one map per minute.

  15. Climatic trends in hail precipitation in France: spatial, altitudinal, and temporal variability.

    PubMed

    Hermida, Lucía; Sánchez, José Luis; López, Laura; Berthet, Claude; Dessens, Jean; García-Ortega, Eduardo; Merino, Andrés

    2013-01-01

    Hail precipitation is characterized by enhanced spatial and temporal variability. Association Nationale d'Etude et de Lutte contre les Fléaux Atmosphériques (ANELFA) installed hailpad networks in the Atlantic and Midi-Pyrénées regions of France. Historical data of hail variables from 1990 to 2010 were used to characterize variability. A total of 443 stations with continuous records were chosen to obtain a first approximation of areas most affected by hail. The Cressman method was selected for this purpose. It was possible to find relationships between spatial distributions of the variables, which are supported by obtained Pearson correlations. Monthly and annual trends were examined using the Mann-Kendall test for each of the total affected hailpads. There were 154 pads with a positive trend; most were located between Tarbes and Saint-Gaudens. We found 177 pads with a negative trend, which were largely south of a pine forest in Landes. The remainder of the study area showed an elevated spatial variability with no pattern, even between relatively close hailpads. A similar pattern was found in Lérida (Spain) and Southeast France. In the entire area, monthly trends were predominantly negative in June, July, and August, whereas May had a positive trend; again, however, there was no spatial pattern. There was a high concentration of hailpads with positive trend near the Pyrenees, probably owing to orographic effects, and if we apply cluster analysis with the Mann-Kendall values, the spatial variability is accentuated for stations at higher altitude.

  16. Climatic Trends in Hail Precipitation in France: Spatial, Altitudinal, and Temporal Variability

    PubMed Central

    Hermida, Lucía; Sánchez, José Luis; López, Laura; Berthet, Claude; Dessens, Jean; García-Ortega, Eduardo; Merino, Andrés

    2013-01-01

    Hail precipitation is characterized by enhanced spatial and temporal variability. Association Nationale d'Etude et de Lutte contre les Fléaux Atmosphériques (ANELFA) installed hailpad networks in the Atlantic and Midi-Pyrénées regions of France. Historical data of hail variables from 1990 to 2010 were used to characterize variability. A total of 443 stations with continuous records were chosen to obtain a first approximation of areas most affected by hail. The Cressman method was selected for this purpose. It was possible to find relationships between spatial distributions of the variables, which are supported by obtained Pearson correlations. Monthly and annual trends were examined using the Mann-Kendall test for each of the total affected hailpads. There were 154 pads with a positive trend; most were located between Tarbes and Saint-Gaudens. We found 177 pads with a negative trend, which were largely south of a pine forest in Landes. The remainder of the study area showed an elevated spatial variability with no pattern, even between relatively close hailpads. A similar pattern was found in Lérida (Spain) and Southeast France. In the entire area, monthly trends were predominantly negative in June, July, and August, whereas May had a positive trend; again, however, there was no spatial pattern. There was a high concentration of hailpads with positive trend near the Pyrenees, probably owing to orographic effects, and if we apply cluster analysis with the Mann-Kendall values, the spatial variability is accentuated for stations at higher altitude. PMID:24307872

  17. Molecular dynamics studies on the NMR and X-ray structures of rabbit prion proteins.

    PubMed

    Zhang, Jiapu; Zhang, Yuanli

    2014-02-07

    Prion diseases, traditionally referred to as transmissible spongiform encephalopathies (TSEs), are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species, manifesting as scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad-cow disease) in cattle, chronic wasting disease in deer and elk, and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and kulu in humans, etc. These neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (PrP(C)) into insoluble abnormally folded infectious prions (PrP(Sc)), and the conversion of PrP(C) to PrP(Sc) is believed to involve conformational change from a predominantly α-helical protein to one rich in β-sheet structure. Such a conformational change may be amenable to study by molecular dynamics (MD) techniques. For rabbits, classical studies show that they have a low susceptibility to be infected by PrP(Sc), but recently it was reported that rabbit prions can be generated through saPMCA (serial automated Protein Misfolding Cyclic Amplification) in vitro and the rabbit prion is infectious and transmissible. In this paper, we first do a detailed survey on the research advances of rabbit prion protein (RaPrP) and then we perform MD simulations on the NMR and X-ray molecular structures of rabbit prion protein wild-type and mutants. The survey shows to us that rabbits were not challenged directly in vivo with other known prion strains and the saPMCA result did not pass the test of the known BSE strain of cattle. Thus, we might still look rabbits as a prion resistant species. MD results indicate that the three α-helices of the wild-type are stable under the neutral pH environment (but under low pH environment the three α-helices have been unfolded into β-sheets), and the three α-helices of the mutants (I214V and S173N) are unfolded into rich β-sheet structures under

  18. CAXII Is a Sero-Diagnostic Marker for Lung Cancer

    PubMed Central

    Kobayashi, Makoto; Matsumoto, Toshihide; Ryuge, Shinichiro; Yanagita, Kengo; Nagashio, Ryo; Kawakami, Yoshitaka; Goshima, Naoki; Jiang, Shi-Xu; Saegusa, Makoto; Iyoda, Akira; Satoh, Yukitoshi; Masuda, Noriyuki; Sato, Yuichi

    2012-01-01

    To develop sero-diagnostic markers for lung cancer, we generated monoclonal antibodies using pulmonary adenocarcinoma (AD)-derived A549 cells as antigens by employing the random immunization method. Hybridoma supernatants were immunohistochemically screened for antibodies with AMeX-fixed and paraffin-embedded A549 cell preparations. Positive clones were monocloned twice through limiting dilutions. From the obtained monoclonal antibodies, we selected an antibody designated as KU-Lu-5 which showed intense membrane staining of A549 cells. Based on immunoprecipitation and MADLI TOF/TOF-MS analysis, this antibody was recognized as carbonic anhydrase XII (CAXII). To evaluate the utility of this antibody as a sero-diagnostic marker for lung cancer, we performed dot blot analysis with a training set consisting of sera from 70 lung cancer patients and 30 healthy controls. The CAXII expression levels were significantly higher in lung cancer patients than in healthy controls in the training set (P<0.0001), and the area under the curve of ROC was 0.794, with 70.0% specificity and 82.9% sensitivity. In lung cancers, expression levels of CAXII were significantly higher in patients with squamous cell carcinoma (SCC) than with AD (P = 0.035). Furthermore, CAXII was significantly higher in well- and moderately differentiated SCCs than in poorly differentiated ones (P = 0.027). To further confirm the utility of serum CAXII levels as a sero-diagnostic marker, an additional set consisting of sera from 26 lung cancer patients and 30 healthy controls was also investigated by dot blot analysis as a validation study. Serum CAXII levels were also significantly higher in lung cancer patients than in healthy controls in the validation set (P = 0.030). Thus, the serum CAXII levels should be applicable markers discriminating lung cancer patients from healthy controls. To our knowledge, this is the first report providing evidence that CAXII may be a novel sero-diagnostic marker for

  19. RELATIONSHIP BETWEEN ZINCEMIA, SUPEROXIDE DISMUTASE ACTIVITY AND MARKER OF OXIDATIVE STRESS IN WOMEN WITH BREAST CANCER.

    PubMed

    Borges de Araújo, Camila Guedes; Oliveira do Nascimento Holanda, Aldenora; de Souza Rocha, Cinthya Vivianne; Soares do Nascimento, Ayla Patricia; Simplício Revoredo, Camila Maria; Borges da Silva, Benedito; do Nascimento Nogueira, Nadir; do Nascimento Marreiro, Dilina

    2015-08-01

    Introducción: diversos estudios muestran alteraciones en el metabolismo del zinc en mujeres con cáncer de mama. Este mineral posee acción antioxidante, y los disturbios en sus parámetros bioquímicos están relacionados con peor pronóstico de la enfermedad y agravamiento del proceso carcinogénico. Objetivos: este estudio evaluó la actividad de la enzima superóxido dismutasa y los parámetros bioquímicos relativos al zinc e investigó la existencia de correlación entre esas variables y el marcador del estrés oxidativo en estas pacientes. Métodos: este fue un estudio caso-control con 66 mujeres, con edad ente 20 y 50 años, distribuidas en: grupo caso (mujeres con cáncer de mama, n = 34) y grupo control (mujeres saludables, n = 32). La ingestión del zinc fue realizada por medio del registro alimentario de tres días, utilizando el programa Nutwin versión 1.5. Las concentraciones de zinc plasmático y eritrocitario fueron determinadas según el método de espectrofotometría de absorción atómica de llama (λ = 213,9). La actividad de la superóxido dismutasa fue evaluada por el método colorimétrico de Griess y fueron analizadas sustancias reactivas al ácido tiobarbitúrico (TBARS). Resultados y discusión: los valores medios de la ingestión de zinc, superóxido dismutasa y TARBS eran superiores a los recomendados para las participantes del estudio, con una diferencia estadística para la enzima superóxido dismutasa (p > 0,05). La media de las concentraciones plasmática y eritrocitaria de zinc fueron reducidos en ambos grupos (p > 0.05). Conclusiones: por lo tanto, se puede suponer que la ingesta de zinc en mujeres con cáncer de mama no influye en las concentraciones plasmáticas y eritrocitarias de ese mineral. La elevada actividad de la superóxido dismutasa en las mujeres con cáncer de mama puede ser debida a un mecanismo de regulación compensatorio mediante el estrés oxidativo presente en esa enfermedad.

  20. Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication.

    PubMed

    Qian, Ziliang; Yin, Yanbin; Zhang, Yong; Lu, Lingyi; Li, Yixue; Jiang, Ying

    2006-04-05

    Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell wall, and its biosynthesis is not yet well characterized. Studies in Bacillus subtilis have discovered two different pathways of teichoic acid biosynthesis, in two strains W23 and 168 respectively, namely teichoic acid ribitol (tar) and teichoic acid glycerol (tag). The genes involved in these two pathways are also characterized, tarA, tarB, tarD, tarI, tarJ, tarK, tarL for the tar pathway, and tagA, tagB, tagD, tagE, tagF for the tag pathway. With the genome sequences of several MRSA strains: Mu50, MW2, N315, MRSA252, COL as well as methicillin susceptible strain MSSA476 available, a comparative genomic analysis was performed to characterize teichoic acid biosynthesis in these S. aureus strains. We identified all S. aureus tar and tag gene orthologs in the selected S. aureus strains which would contribute to teichoic acids sythesis. Based on our identification of genes orthologous to tarI, tarJ, tarL, which are specific to tar pathway in B. subtilis W23, we also concluded that tar is the major teichoic acid biogenesis pathway in S. aureus. Further analyses indicated that the S. aureus tar genes, different from the divergon organization in B. subtilis, are organized into several clusters in cis. Most interesting, compared with genes in B. subtilis tar pathway, the S. aureus tar specific genes (tarI,J,L) are duplicated in all six S. aureus genomes. In the S. aureus strains we analyzed, tar (teichoic acid ribitol) is the main teichoic acid biogenesis pathway. The tar genes are organized into several genomic groups in cis and the genes specific to tar (relative to tag): tarI, tarJ, tarL are duplicated. The genomic organization of the S. aureus tar pathway suggests their regulations are different when compared to B. subtilis tar or tag pathway, which are

  1. Structurally distinct domains in the Indian NW-Himalaya, constrained by AFT and ZHe thermochronology

    NASA Astrophysics Data System (ADS)

    Deeken, Anke; Hourigan, Jeremy K.; Thiede, Rasmus T.; Sobel, Edward R.; Strecker, Manfred R.

    2010-05-01

    The Himalayan orogen is commonly divided into orogen-parallel, faultbound structural units that extend along the entire length of the orogen. However, significant along-strike variations of the Himalayan architecture occure, and topography, local relief and the distribution of precipitation vary from west to east. We apply apatite fission-track (AFT) and zircon (U-Th)/He (ZHe) thermochronometry to constrain spatial and temporal variations in exhumation, and along strike variations in the timing and magnitude of deformation in the Indian NW-Himalaya. We present ca. 28 new AFT and 30 new ZHe cooling ages from the Chamba-Zanskar region that is situated between the Kishtwar and the Larji-Kulu-Rampur windows. The approximately 100 km long sampling transect across the High Himalaya is oriented perpendicular to the major structures of the Himalayan orogen. The transect extends from the southern Himalayan front, that is characterised by concentrated monsoonal precipitation, to the arid interior of the orogen. The bedrock samples were collected in the hanging wall of the MCT from 3 vertical profiles, which span between 2400 m and 3600 m. Our new cooling ages constrain the exhumation history of the Chamba-Zanskar region spanning from the Miocene until present. ZHe and AFT cooling ages range between 6.4 and 18.1 Ma, and 1.7 and 9.3 Ma, respectively. Our new data reveal spatial-temporal variation in the exhumation between the frontal range and the more internal compartments of the High Himalaya. AFT ages, and to some degree ZHe ages at the southernmost frontal range are all young (<3.7 Ma and <9.2 Ma, respectively) despite the high vertical offset (2870 m) between the samples. At the internal ranges to the north, ZHe ages as well as AFT ages are older (9.4-18.1 Ma and 3.8-9.3 Ma, respectively), and sytematically increase with sample elevation. Our preliminary interpretation of these observations is that as a consequence of moderate exhumation rates at earlier times (Miocene

  2. Long-term erosion and exhumation rates across different climatic zones in the Indian NW-Himalaya

    NASA Astrophysics Data System (ADS)

    Deeken, A.; Hourigan, J. K.; Thiede, R. C.; Sobel, E. R.; Strecker, M. R.

    2009-12-01

    Concepts have been developed that explain the changeover from tectonically to erosionally controlled exhumation processes in the tectonic evolution of the Himalayan orogen. However, the degree to which climate-driven erosion controls the late Cenozoic development of the southern Himalayan front is still a matter of debate. The Himalaya forms an orographic barrier with strong gradients both perpendicular to and along strike of the orogen. Thus, quantifying whether or not precipitation, erosion, and deformation patterns are correlated over geologic time should provide important insights into the tectonic evolution of the orogen. To constrain spatial and temporal variations in erosion and along strike variations in the timing and magnitude of deformation in the NW-Himalaya, we are establishing a data set of multiple low-temperature thermochronometers. Together with previous published data, our new apatite fission track (AFT) and zircon (U-Th)/He ages (ZHe) ages will be integrated with 3D-thermo-kinematic modeling. On a first sampling campaign, we collected 40 bedrock samples from the hanging wall of the MCT along an approximately 100 km long, strike perpendicular transect across the High Himalaya of the Chamba/Zanskar region that is situated between the Kishtwar- and the Larji-Kulu-Rampur-Windows. It extends from the southern Himalayan front, that is characterised by concentrated monsoonal precipitation, to the arid interior of the orogen. We present ca. 33 new AFT and 30 new ZHe from 3 elevation transects, which span between 2400 m and 3600 m. Our data constrain the exhumation history of the Chamba/Zanskar region spanning from the Miocene until present. ZHe and AFT ages range between 6.3 and 18.1 Ma, and 1.7 and 9.3 Ma, respectively. Our new data reveal spatiotemporal variation in the exhumation between the frontal range and the more internal compartments of the High Himalaya. At the internal ranges to the north, ZHe ages (9.4-18.1 Ma) as well as AFT ages (3.8-9.3 Ma

  3. Molecular dynamics studies on the buffalo prion protein.

    PubMed

    Zhang, Jiapu; Wang, Feng; Chatterjee, Subhojyoti

    2016-01-01

    It was reported that buffalo is a low susceptibility species resisting to transmissible spongiform encephalopathies (TSEs) (same as rabbits, horses, and dogs). TSEs, also called prion diseases, are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of species (except for rabbits, dogs, horses, and buffalo), manifesting as scrapie in sheep and goats; bovine spongiform encephalopathy (BSE or "mad-cow" disease) in cattle; chronic wasting disease in deer and elk; and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and Kulu in humans etc. In molecular structures, these neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (PrP(C)), predominantly with α-helices, into insoluble abnormally folded infectious prions (PrP(Sc)), rich in β-sheets. In this article, we studied the molecular structure and structural dynamics of buffalo PrP(C) (BufPrP(C)), in order to understand the reason why buffalo is resistant to prion diseases. We first did molecular modeling of a homology structure constructed by one mutation at residue 143 from the NMR structure of bovine and cattle PrP(124-227); immediately we found that for BufPrP(C)(124-227), there are five hydrogen bonds (HBs) at Asn143, but at this position, bovine/cattle do not have such HBs. Same as that of rabbits, dogs, or horses, our molecular dynamics studies also revealed there is a strong salt bridge (SB) ASP178-ARG164 (O-N) keeping the β2-α2 loop linked in buffalo. We also found there is a very strong HB SER170-TYR218 linking this loop with the C-terminal end of α-helix H3. Other information, such as (i) there is a very strong SB HIS187-ARG156 (N-O) linking α-helices H2 and H1 (if mutation H187R is made at position 187, then the hydrophobic core of PrP(C) will be exposed (L.H. Zhong (2010). Exposure of hydrophobic core in human prion protein pathogenic mutant H187R. Journal of

  4. Application of the "Behind the Barriers" resilience conceptual model to a flooded rail transport system

    NASA Astrophysics Data System (ADS)

    Gonzva, Michael; Barroca, Bruno

    2017-04-01

    The vulnerability of guided transport systems facing natural hazards is a burning issue for the urban risks management. Experience feedbacks on guided transport systems show they are particularly vulnerable to natural risks, especially flood risks. Besides, the resilience concept is used as a systemic approach for making an accurate analysis of the effect of these natural risks on rail guided transport systems. In this context, several conceptual models of resilience are elaborated for presenting the various possible resilience strategies applied to urban technical systems. One of this resilience conceptual model is the so-called "Behind The Barriers" model based on the identification of four complementary types of resilience: (i) cognitive resilience, linked to knowledge of the risk and the potential failures; (ii) functional resilience, representing the capacity of a system to protect itself from damage while continuing to provide services; (iii) correlative resilience, that characterises the relationship between service demand and the capacity of the system to respond; (iv) organisational resilience, expressing the capacity to mobilise an area much wider than the one affected. In addition to the work already published during the 7th Resilience Engineering Symposium, the purpose of this paper is to offer an application of a resilience conceptual model, the "Behind the Barriers" model, relating to a specific urban technical system, the public guided transport system, and facing a particular risk, a flood hazard. To do that, the paper is focused on a past incident on a French Intercity railway line as a studied case. Indeed, on June 18th and 19th 2013, the rise of the level of the "Gave de Pau" river, located in the municipality of Coarraze, caused many disorders on the intercity line serving the cities of Tarbes, Pau and Lourdes . Among the disorders caused by the flooding, about 100 meters of railway embankments were collapsed. With a constraint to reopen the

  5. NOWVIV - Nowcasting wake vortex impact variables

    NASA Astrophysics Data System (ADS)

    Tafferner, A.; Birke, L.; Frech, M.

    2003-04-01

    A central task of the ongoing DLR project "Wirbelschleppe" (Wake Vortex) is to forecast meteorological quantities which influence the behaviour of wake vortices of landing aircraft. In the first place these are wind, temperature and turbulence, resp. the vertical shear thereof, which impact the lateral drift and turbulent decay of wake vortices. For this purpose the nowcasting system NOWVIV has been developed at DLR. It combines operational forecasts of the Lokal Modell (LM; Doms and Schaettler 1999) of the German weather service DWD with a high-resolution forecasting system. For the latter, the NOAA/FSL version of the mesoscale model MM5 (Grell et al. 2000) has been adapted to particular sites. Orography, land use, and soil type have been generated from available data sources for a 80 km square domain centered on a particular airport with a horizontal resolution of 2.1 km. As a good representation of the boundary layer is of particular importance for predicting wake vortex impact variables, the vertical spacing of model layers has been selected rather small throughout the lower model atmosphere, starting with 20 m at the ground and increasing to about 60 m at 2 km height. NOWVIV delivers vertical profiles of vortex impact variables, which are used by the wake prediction model ``P2P'' developed at DLR (Holzaepfel 2002) to predict wake vortex behaviour. During the two field campaigns ``WakeOP'' and ``WakeTOUL'' in April/May 2001 and May/June 2002 which aimed at measuring (by lidar) and predicting wake vortex behaviour of landing aircraft, NOWVIV has been run in an operational mode for the airports of Oberpfaffenhofen (Germany) and Tarbes (France). A statistical evaluation of the NOWVIV forecasting performance during these campaigns achieved satisfactory results as compared to local measurements of wind and temperature from radio acoustic sounding instruments (Frech et al. 2002). However, there are uncertainties in the daily variation of the boundary layer. Also, the

  6. Is This Speck of Light an Exoplanet?

    NASA Astrophysics Data System (ADS)

    2004-09-01

    ). A preprint is available here and also as astro-ph0409323. Notes [1]: This press release is issued simultaneously by ESO and CNRS (in French). [2]: The team consists of Gael Chauvin and Christophe Dumas (ESO-Chile), Anne-Marie Lagrange and Jean-Luc Beuzit (LAOG, Grenoble, France), Benjamin Zuckerman and Inseok Song (UCLA, Los Angeles, USA), David Mouillet (LAOMP, Tarbes, France) and Patrick Lowrance (IPAC, Pasadena, USA). The American members of the team acknowledge funding in part by NASA's Astrobiology Institute. [3]: The NACO facility (from NAOS/Nasmyth Adaptive Optics System and CONICA/Near-Infrared Imager and Spectrograph) at the 8.2-m VLT Yepun telescope on Paranal offers the capability to produce diffraction-limited near-infrared images of astronomical objects. It senses the radiation in this wavelength region with the N90C10 dichroic; 90 percent of the flux is transmitted to the wavefront sensor and 10 percent to the near-infrared camera CONICA. This mode is particularly useful for sharp imaging of red and very-low-mass stellar or substellar objects. The adaptive optics corrector (NAOS) was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA), Laboratoire d'Astrophysique de Grenoble (LAOG) and the LESIA and GEPI laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. [4]: What is the difference between a small brown dwarf and an exoplanet ? The border line between the two is still being investigated but it appears that a brown dwarf object is formed in the same way as stars, i.e. by contraction in an interstellar cloud while planets are formed within stable circumstellar disks via collision/accretion of planetesimals or disk instabilities. This implies that brown