Sample records for laboratories ma60 acrysof

  1. AcrySof Natural SN60AT versus AcrySof SA60AT intraocular lens in patients with color vision defects.

    PubMed

    Raj, Shetal M; Vasavada, Abhay R; Nanavaty, Mayank A

    2005-12-01

    To determine whether implantation of the AcrySof Natural intraocular lens (IOL) worsened the severity of existing color deficit in congenital partial red-green color deficient individuals (CPRG). A prospective controlled randomized double-masked analysis of 30 consecutive patients with CPRG defect and bilateral cataracts received a Natural IOL (test group) in 1 eye and a single-piece AcrySof IOL (control group) in the other eye. Patients were tested unilaterally to detect CPRG defect using Ishihara pseudoisochromatic plates and the Farnsworth D-15 test. Plates 1 to 21 measured the Ishihara error score; plates 22 to 25 indicated severity of defect based on clarity of both numerals as partial mild/moderate (both visible), partial severe defect (only 1 visible). The D-15 test is based on number of diametrical crossings on the circular diagram; severity is graded as mild (1 crossing), moderate (2 crossings), or severe (>2 crossings). Tests were performed before and after IOL implantation at 1, 3, and 6 months. At mean follow-up of 6.13 months +/- 1.2 (SD), analysis of variance test judged the difference in error scores and cross tabulation represented change in number of diametrical crossings. The mean age was 62.3 +/- 8.5 years. All patients were men. Before IOL implantation, all patients had moderate CPRG defect on both tests. The Ishihara error score in the test and control groups did not reveal statistically significant differences (P = .505 and P = .119, respectively). With D-15, none of the patients in the test or control group showed >2 crossings. The implantation of AcrySof Natural IOL did not worsen the preexisting severity of color defect in CPRG individuals.

  2. Light scatter on the surface of AcrySof intraocular lenses: part I. Analysis of lenses retrieved from pseudophakic postmortem human eyes.

    PubMed

    Yaguchi, Shigeo; Nishihara, Hitoshi; Kambhiranond, Waraporn; Stanley, Daniel; Apple, David J

    2008-01-01

    To investigate the cause of light scatter measured on the surface of AcrySof intraocular lenses (Alcon Laboratories, Inc., Fort Worth, TX) retrieved from pseudophakic postmortem human eyes. Ten intraocular lenses (Alcon AcrySofModel MA60BM) were retrieved postmortem and analyzed for light scatter before and after removal of surface-bound biofilms. Six of the 10 lenses exhibited light scatter that was clearly above baseline levels. In these 6 lenses, both peak and average pixel density were reduced by approximately 80% after surface cleaning. The current study demonstrates that a coating deposited in vivo on the lens surface is responsible for the light scatter observed when incident light is applied.

  3. Light scatter on the surface of AcrySof intraocular lenses: part II. Analysis of lenses following hydrolytic stability testing.

    PubMed

    Yaguchi, Shigeo; Nishihara, Hitoshi; Kambhiranond, Waraporn; Stanley, Daniel; Apple, David

    2008-01-01

    To investigate the surface light scatter and optical quality of AcrySof lenses (Alcon Laboratories, Inc., Fort Worth, TX) following simulated aging of 20 years. AcrySof lenses were exposed to exaggerated thermal conditions to simulate up to 20 years of aging and were tested for surface light scatter and optical quality (modulation transfer function). There were no significant differences from baseline for either the surface light scatter or optical quality of the lenses over time. The current study demonstrated that surface light scatter on AcrySof lenses did not increase under conditions simulating 20 years of aging. Because the simulated aging environment contained no protein, this work indirectly supports the finding that surface light scatter is due to the deposition of a biomaterial on the lens surface rather than changes in the material. Optical performance integrity of the test lenses was maintained under severe environmental conditions.

  4. Distance vision after bilateral implantation of AcrySof toric intraocular lenses: a randomized, controlled, prospective trial

    PubMed Central

    Zhang, Jin-Song; Zhao, Jiang-Yue; Sun, Qi; Ma, Li-Wei

    2011-01-01

    AIM To evaluate the distance vision of Chinese patients with cataracts and corneal astigmatism after implantation of bilateral AcrySof toric intraocular lens (IOL) versus bilateral AcrySof spherical IOL. METHODS This study randomized 60 patients into equal groups to receive toric IOL or spherical IOL. IOL powers targeting emmetropia were selected for 93% of toric IOL patients and for 90% of spherical IOL patients. Assessments included monocular and binocular distance vision, with and without best correction. Patients also completed surveys about their distance vision. RESULTS Preoperatively, the two study groups were similar in age, in distance visual acuity, and in the magnitude of corneal astigmatism. At 6 months postoperative, binocular uncorrected distance vision was 0.06±0.14 logMAR in the AcrySof toric IOL group, significantly better than the 0.14±0.11 logMAR in the spherical IOL group (P<0.05). For eyes with emmetropia as a target, the equivalent of 20/20 uncorrected vision was more likely (P<0.001) in the toric IOL group (36% of eyes) than in the spherical IOL group (4% of eyes). No patients in the emmetropia/toric IOL group used distance glasses, as compared to 52% of patients in the emmetropia/spherical IOL group. All patients were satisfied or highly satisfied. Quality of distance vision was rated higher by toric IOL patients than by spherical IOL patients (P<0.05). CONCLUSION Bilateral AcrySof toric IOL is superior to bilateral spherical IOL in providing uncorrected distance vision to cataract patients with corneal astigmatism. PMID:22553636

  5. Sulcus implantation of a 3-piece, 6.0 mm optic, hydrophobic foldable acrylic intraocular lens in phacoemulsification complicated by posterior capsule rupture.

    PubMed

    Brazitikos, Periklis D; Balidis, Miltiadis O; Tranos, Paris; Androudi, Sofia; Papadopoulos, Nick T; Tsinopoulos, Ioannis T; Karabatakis, Vasilios; Stangos, Nikolaos T

    2002-09-01

    To evaluate the safety of implanting a 3-piece, 6.0 mm optic, foldable acrylic intraocular lens (IOL) in cases of posterior capsule rupture during phacoemulsification. Department of Ophthalmology, Ahepa Hospital, Aristotle University Medical School, and Interbalkan Medical Center, Thessaloniki, Greece. This prospective noncomparative case series included 28 eyes (28 patients) having phacoemulsification complicated by extensive posterior capsule rupture with or without vitreous loss. In all eyes, a 3-piece, 6.0 mm optic, foldable acrylic IOL (AcrySof MA60BM, Alcon) was implanted in the sulcus. Postoperative examination included best corrected visual acuity (BCVA), anterior segment biomicroscopy, IOL centralization and position, intraocular pressure (IOP), and fundus biomicroscopy. The follow-up was 6 months. The most common postoperative complications were transient corneal edema in 12 eyes and increased IOP in 11 eyes. Slight asymptomatic decentralization from the center of the pupil (1.0 to 2.0 mm) and pseudophacodonesis were observed in 5 eyes each. Friction of the IOL with the iris occurred in 1 eye. Clinically significant cystoid macular edema occurred in 3 eyes. The final BCVA was between 20/15 and 20/25 in 18 patients, 20/30 in 2, between 20/40 and 20/50 in 4, and between 20/60 and 20/200 in 4. AcrySof IOL implantation in the sulcus during phacoemulsification complicated by posterior capsule rupture preserved the advantages of small-incision surgery. The postoperative behavior and centralization of the IOLs resembled those of poly(methyl methacrylate) lenses.

  6. Scanning electron microscopic and histologic evaluation of the AcrySof SA30AL acrylic intraocular lens. Manufacturing quality and morphology in the capsular bag.

    PubMed

    Escobar-Gomez, Marcela; Apple, David J; Vargas, Luis G; Werner, Liliana; Arthur, Stella N; Pandey, Suresh K; Izak, Andrea M; Schmidbauer, Josef M

    2003-01-01

    To evaluate the properties of the AcrySof(R) SA30AL (Alcon Laboratories, Inc.) single-piece foldable posterior chamber intraocular lens (IOL). Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA. Two nonimplanted clinical-quality AcrySof IOLs were examined by gross, light, and scanning electron microscopy (SEM). In addition, 2 eyes implanted with this IOL obtained post-mortem, the first such eyes accessioned in our laboratory and the first described to date, were examined using the Miyake-Apple posterior photographic technique and by histologic sections. Scanning electron microscopy of the SA30AL IOL showed excellent surface finish. The edge of the optic was square (truncated) and had a matte (velvet or ground-glass) appearance, a feature that may minimize edge glare and other visual phenomena. A well-fabricated square or truncated optic edge was demonstrated. Miyake-Apple analysis revealed that the SA30AL IOL showed appropriate fit and configuration within the capsular bag. Histologic correlation of the IOL's square edge and its relation to the capsular bag and adjacent Soemmering's ring were noted. The AcrySof SA30AL IOL is a well-fabricated lens that situates well in the capsular bag. The truncated optic and its relationship to adjacent structures show a morphological profile that has been shown to be highly efficacious in reducing the rate of posterior capsule opacification.

  7. 40 CFR 60.535 - Laboratory accreditation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Wood Heaters § 60.535 Laboratory accreditation. (a)(1) A laboratory may apply for accreditation by the Administrator to conduct wood heater certification tests pursuant to § 60.533. The application shall be in writing to: Emission Measurement Branch (MD-13), U.S. EPA, Research Triangle Park, NC 27711, Attn: Wood...

  8. 40 CFR 60.535 - Laboratory accreditation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Wood Heaters § 60.535 Laboratory accreditation. (a)(1) A laboratory may apply for accreditation by the Administrator to conduct wood heater certification tests pursuant to § 60.533. The application shall be in writing to: Emission Measurement Branch (MD-13), U.S. EPA, Research Triangle Park, NC 27711, Attn: Wood...

  9. 40 CFR 60.535 - Laboratory accreditation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Wood Heaters § 60.535 Laboratory accreditation. (a)(1) A laboratory may apply for accreditation by the Administrator to conduct wood heater certification tests pursuant to § 60.533. The application shall be in writing to: Emission Measurement Branch (MD-13), U.S. EPA, Research Triangle Park, NC 27711, Attn: Wood...

  10. 40 CFR 60.535 - Laboratory accreditation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Wood Heaters § 60.535 Laboratory accreditation. (a)(1) A laboratory may apply for accreditation by the Administrator to conduct wood heater certification tests pursuant to § 60.533. The application shall be in writing to: Emission Measurement Branch (MD-13), U.S. EPA, Research Triangle Park, NC 27711, Attn: Wood...

  11. 40 CFR 60.535 - Laboratory accreditation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Wood Heaters § 60.535 Laboratory accreditation. (a)(1) A laboratory may apply for accreditation by the Administrator to conduct wood heater certification tests pursuant to § 60.533. The application shall be in writing to: Emission Measurement Branch (MD-13), U.S. EPA, Research Triangle Park, NC 27711, Attn: Wood...

  12. Suppression of retroviral MA deletions by the amino-terminal membrane-binding domain of p60src.

    PubMed Central

    Wills, J W; Craven, R C; Weldon, R A; Nelle, T D; Erdie, C R

    1991-01-01

    The molecular mechanism by which retroviral Gag proteins are directed to the plasma membrane for the formation of particles (budding) is unknown, but it is widely believed that the MA domain, located at the amino terminus, plays a critical role. Consistent with this idea, we found that small deletions in this segment of the Rous sarcoma virus Gag protein completely blocked particle formation. The mutant proteins appear to have suffered only localized structural damage since they could be rescued (i.e., packaged into particles) when coexpressed with Gag proteins that are competent for particle formation. To our surprise, the effects of the MA deletions could be completely suppressed by fusing as few as seven residues of the myristylated amino terminus of the oncoprotein p60src to the beginning of the mutant Gag proteins. Particles produced by the chimeras were of the same density as the wild type. Two myristylated peptides having sequences distinct from that of p60src were entirely unable to suppress MA deletions, indicating that myristate alone is not a sufficient membrane targeting signal. We hypothesize that the amino terminus of p60src suppresses the effects of MA deletions by diverting the Rous sarcoma virus Gag protein from its normal site of assembly to the Src receptor for particle formation. Images PMID:1710290

  13. Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

    PubMed

    Ortega Suero, G; Sola-Valls, N; Escudero, D; Saiz, A; Graus, F

    Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. 60 Years of Great Science (Oak Ridge National Laboratory)

    DOE R&D Accomplishments Database

    2003-01-01

    This issue of Oak Ridge National Laboratory Review (vol. 36, issue 1) highlights Oak Ridge National Laboratory's contributions in more than 30 areas of research and related activities during the past 60 years and provides glimpses of current activities that are carrying on this heritage.

  15. A 60 mA DC H- multi cusp ion source developed at TRIUMF

    NASA Astrophysics Data System (ADS)

    Jayamanna, K.; Ames, F.; Bylinskii, I.; Lovera, M.; Minato, B.

    2018-07-01

    This paper describes the latest high-current multi cusp type ion source developed at TRIUMF, which is capable of producing a negative hydrogen ion beam (H-) of 60 mA of direct current at 140V and 90A arc. The results achieved to date including emittance measurements and filament lifetime issues are presented. The low current version of this ion source is suitable for medical cyclotrons as well as accelerators and the high current version is intended for producing large neutral hydrogen beams for fusion research. The description of the source magnetic configuration, the electron filter profile and the differential pumping techniques given in the paper will allow the building of an arc discharge H- ion source with similar properties.

  16. In vitro optical quality of monofocal aspheric toric intraocular lenses: effect of cylindrical power.

    PubMed

    Ferrer-Blasco, Teresa; Domínguez-Vicent, Alberto; García-Lázaro, Santiago; Diez, María Amparo; Alfonso, José F; Esteve-Taboada, José J

    2018-06-01

    To assess the in vitro optical quality of monofocal aspheric toric intraocular lenses (IOLs) as a function of the cylindrical power. The in vitro optical quality of the AcrySof IQ Toric IOLs SN6AT2, SN6AT3, SN6AT4, SN6AT5 and SN6AT6 (Alcon Laboratories Inc., Forth Worth, TX, USA) was assessed with an instrument conceived for measuring Zernike's coefficients at 3.0- and 5.0-mm apertures. As a reference, the aspheric monofocal lens AcrySof IQ Aspheric SN60WF (Alcon Laboratories Inc., Forth Worth, TX, USA) was also measured. The area of visibility and cut-off frequency were used to describe the modulation transfer function (MTF) of each lens; meanwhile, the light in the bucket and the diameter of a circular area centred on the point-spread function (PSF) peak that captures 50% of the light energy were used to describe the PSF of each lens. Finally, an image simulation was computed from the Zernike values with reference purposes. Small differences were found on the metrics used for describing the MTF and PSF of the lenses at both tested apertures, but these were not statistically significant (p > 0.05). Furthermore, the image simulation showed that these differences would not have clinical relevance at all. The optical performance of the AcrySof IQ toric IOLs in terms of MTF and PSF is good and seems to be independent of the cylindrical power and similar to a non-toric aspheric lens.

  17. Near visual acuity for everyday activities with accommodative and monofocal intraocular lenses.

    PubMed

    Sanders, Donald R; Sanders, Monica L

    2007-10-01

    To determine the levels of functional near visual acuity required for everyday social reading activities and to compare the levels to those attained with accommodative and monofocal intraocular lenses (LOLs). Font size equivalencies of an Early Treatment Diabetic Retinopathy Study near chart and a variety of commonly read print objects were determined and correlated to the findings of distance-corrected near vision measurements with 2 accommodative (Tetraflex, 1CU) and 1 monofocal (Acrysof MA30) IOLs. The smallest print objects studied were sweetener packets with type between 20/40 (Jaeger [J] 5) and 20/50 (J6). Type in classified ads, stock quotations, and pocket bibles was 20/50 (J6), type in a telephone directory was 20/63 (J8), and type in standard newspapers, journals, and magazines was 20/80 (J9). Tested monocularly, 88% of Tetraflex, 40% of ICU, and 7% of Acrysof MA30 eyes had distance-corrected near vision sufficient to read newspaper and telephone directory print, and 63% of Tetraflex, 30% of 1CU, and 0% of Acrysof MA30 eyes could read classified ads, stock quotations, and pocket bibles, respectively. Tested binocularly after bilateral implantation, 96% of Tetraflex patients could read telephone directory print and 89% could read ads, stock quotations, and pocket bibles. Functional near visual acuity is not equivalent to the bottom-line objective at 20/20 (J1) near visual acuity. No print size was found at or smaller than 20/40 (J5), indicating that a requirement of nearly perfect near visual acuity, while desirable, may not be necessary for patients' social reading needs for accommodative IOLs.

  18. Experimental Physical Sciences Vistas: MaRIE (draft)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shlachter, Jack

    To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materialsmore » science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national

  19. Perspective: C60+ and laboratory spectroscopy related to diffuse interstellar bands

    NASA Astrophysics Data System (ADS)

    Campbell, E. K.; Maier, J. P.

    2017-04-01

    In the last 30 years, our research has focused on laboratory measurements of the electronic spectra of organic radicals and ions. Many of the species investigated were selected based on their potential astrophysical relevance, particularly in connection with the identification of appealing candidate molecules for the diffuse interstellar absorptions. Notably, carbon chains and derivatives containing hydrogen and nitrogen atoms in their neutral and ionic forms were studied. These data could be obtained after developing appropriate techniques to record spectra at low temperatures relevant to the interstellar medium. The measurement of gas phase laboratory spectra has enabled direct comparisons with astronomical data to be made and though many species were found to have electronic transitions in the visible where the majority of diffuse bands are observed, none of the absorptions matched the prominent interstellar features. In 2015, however, the first carrier molecule was identified: C60 + . This was achieved after the measurement of the electronic spectrum of C60 + -He at 6K in a radiofrequency ion trap.

  20. The disruption of H and L ordinary chondrite parent bodies at 60 Ma

    NASA Astrophysics Data System (ADS)

    Blackburn, T.; Alexander, C.; Carlson, R.; Elkins-Tanton, L. T.

    2016-12-01

    A working timeline for the history of ordinary chondrites (OCs) includes chondrule formation as early as 1-2 Ma after our Solar System's earliest forming solids (CAIs), followed by rapid accretion into undifferentiated planetesimals that were heated internally by 26Al decay and cooled over a period of tens of millions of years. There remains conflict, however, between metallographic cooling rates and radioisotopic thermochronometric data over the sizes and lifetimes of the chondrite parent bodies, as well as the timing of impact related disruption. The importance of establishing the timing of parent body disruption is heightened by the use of meteorites as recorders of asteroid belt wide disruption events as suggested by various dynamical models. Here we attempt to resolve these records with new Pb-phosphate dates for 9 previously unstudied OCs. These new results, along with previously published Pb-phosphate and metallographic data, are interpreted with a series of numerical models designed to simulate the thermal evolution for a chondrite parent body that is disrupted by impact prior to forming smaller unsorted "rubble piles". One model that could satisfy both the available thermochronologic and Ni-metal data takes into account subtle differences in closure temperatures for each system. It requires that disruption occur early enough such that the Ni-metal system can record the cooling rate associated with a rubble pile (<70 Ma), yet late enough that the Pb-phosphate system can record an onion shell structure (>30 Ma). For this 30-70 Ma timeline, reaccretion into smaller rubble piles will ensure that the originally deeply buried and hot Type 6 samples will always cool faster as a result of disruption, yielding nearly uniform ages that date parent body disruption. This is consistent with the available Pb-phosphate data, where all but one Type 6 chondrite (H, n=3; L, n=4) records a uniform cooling age (4508 ± 5 Ma). Our model results suggest that a disruption at

  1. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  2. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  3. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  4. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  5. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  6. Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.

    PubMed

    Palmeira dos Santos, Caroline; Pereira, Gustavo J S; Barbosa, Christiano M V; Jurkiewicz, Aron; Smaili, Soraya S; Bincoletto, Claudia

    2014-06-01

    As the molecular mechanisms of Cytarabine,one of the most important drugs used in the leukaemia’s treatment, are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) as autophagy inhibitors, we aim to evaluate the contribution of an autophagic mechanism to Cytarabine (AraC)-induced death of HL60 leukaemia cells. Trypan blue exclusion and AnnexinV/PI assays were used to evaluate HL60 cell death under AraC treatment in the presence or absence of 3MA and CQ. Western blotting and immunofluorescence experiments were performed to show the involvement of apoptosis and autophagy protein expressions. Phenotypic characterization of HL60-treated cells was performed by using immunophenotyping. Clonogenic assays were applied to analyse clonal function of HL60-treated cells. We observed that although autophagy inhibition by 3MA, but not CQ, increased the death of HL60 AraC cells after 24 h of treatment, no significant differences between AraC and AraC + 3MA-treated groups were observed by using clonogenic assay. In addition, increased number of immature (CD34(+)/CD38(−)Lin(−/low)) HL60 cells was found in AraC and AraC-3MA groups when compared with control untreated cells. Although AraC anti-leukaemia effects could be potentiated by 3MA autophagy inhibition after 24 h of exposure, leukaemia cell resistance, the main causes of treatment failure, is also promoted by autophagy initial stage impairment by 3MA, denoting the complex role of autophagy in leukaemia cells’ response to chemotherapy.

  7. Volcano-tectonic evolution of the Castle Mountains: 22 to 14 MA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Capps, R.C.

    1993-04-01

    The alkali-calcic Castle Mountains Volcanic rocks (CMV) are host to major gold mineralization. They are located about 100 km south of Las Vegas, Nevada and are on the boundary between the Basin and Range Province and Colorado River extensional corridor (35[degree]18 minutes 45 seconds N, 115[degree]05 minutes 10 seconds W). New data show the following chronology. 22 Ma. A regional rhyolite ash-flow tuff, the Castle Mountain Tuff member, was deposited on a Proterozoic-Paleozoic basement of low relief. <22 Ma - > 17 Ma. Normal faulting (N30--60[degree]W, 60--65[degree]NE) formed half-grabens. Latite and basalt flows, minor ash-flow tuffs, lahars and sediments (Jacksmore » Well member - JW) were deposited unconformably. JW magmas are enriched in light REE compared to the younger CMV. <17 Ma to 15.5 Ma. Oxidizing upper portions (796 C) of a shallowly emplaced silicic melt erupted to form the high-silica rhyolite dome complexes and intrusives (Linder Peak member - LP) of the NNE-striking Castle Mountains. NW-striking transverse structures caused discontinuities in strike direction of the subvolcanic intrusive and domes and helped form a synvolcanic depression. During a hiatus in volcanism, early Hart Peak member (HP) sediments were deposited marginal to the Castle Mountains. Major gold mineralization and widespread hydrothermal alteration occurred at about 15.5 Ma. 16 Ma to 14 Ma. Early HP volcaniclastic sediments, rhyolite pyroclastic-surge tuff, and basaltic flows, were deposited during late hydrothermal alteration and then fractured and displaced by NNE-striking normal faults, especially in the eastern and northeastern CMV. < 14 Ma. Tectonically significant flat-lying boulder conglomerate and unconformably overlying, largely andesitic flows fill depressions in the Castle Mountains and the Piute Range to the east.« less

  8. Instrumental studies on silicone oil adsorption to the surface of intraocular lenses

    NASA Astrophysics Data System (ADS)

    Kim, Chun Ho; Joo, Choun-Ki; Chun, Heung Jae; Yoo, Bok Ryul; Noh, Dong Il; Shim, Young Bock

    2012-12-01

    The purpose of this study was to examine the degree of adherence of silicone oil to various intraocular lenses (IOLs) through comparison of the physico-chemical properties of the oil and IOLs. Four kinds of IOLs comprising various biomaterials were examined: PMMA (720A™), PHEMA (IOGEL 1103™), Acrysof (MA60BM™), and silicone (SI30NB™). Each lens was immersed in silicone oil or carboxylated silicone (CS-PDMS) oil for 72 h. For determination of the changes in chemical and elemental compositions on the surfaces of IOLs caused by the contact with silicone oil, IOLs were washed and rinsed with n-pentane to remove as much of the adsorbed silicone oil as possible, then subjected to Fourier transform infrared spectroscopic (FTIR) and X-ray photoelectron spectroscopic (XPS) analyses. The results of FTIR studies strongly indicate that washing with n-pentane completely removed the adhered silicone oil on the surfaces of PHEMA and Acrysof IOLs, whereas the residual silicone oil was detected on the surfaces of PMMA and silicone IOLs. XPS studies showed that silicone oil coverage of PMMA lenses was 12%, even after washing with n-pentane. In the case of silicone IOLs, the relative O1s peak area of carboxyl group in the residual CS-PDMS oil was found to be ˜2.7%. Considering that 2.8% carboxyl group-substituted silicone oil was used in the present study, CS-PDMS oil covered the entire surface of the silicone IOLs.

  9. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    NASA Astrophysics Data System (ADS)

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; Hwang, Ho Seong; Utsumi, Yousuke; Diaferio, Antonaldo

    2018-04-01

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ∼20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. We evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at the lowest richness. Three massive galaxy clusters (M ∼ 2 × 1013 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.

  10. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    DOE PAGES

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; ...

    2018-04-05

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ~20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. Here, we evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at themore » lowest richness. Three massive galaxy clusters (M ~ 2 × 10 13 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.« less

  11. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ~20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. Here, we evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at themore » lowest richness. Three massive galaxy clusters (M ~ 2 × 10 13 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.« less

  12. Modern dosimetric tools for 60Co irradiation at high containment laboratories

    PubMed Central

    Twardoski, Barri; Feldmann, Heinz; Bloom, Marshall E.; Ward, Joe

    2011-01-01

    Purpose To evaluate an innovative photo-fluorescent film as a routine dosimetric tool during 60Co irradiations at a high containment biological research laboratory, and to investigate whether manufacturer-provided chamber exposure rates can be used to accurately administer a prescribed dose to biological specimens. Materials and methods Photo-fluorescent, lithium fluoride film dosimeters and National Institutes of Standards and Technology (NIST) transfer dosimeters were co-located in a self-shielded 60Co irradiator and exposed to γ-radiation with doses ranging from 5–85 kGy. Film dose-response relationships were developed for varying temperatures simulating conditions present when irradiating infectious biological specimens. Dose measurement results from NIST transfer dosimeters were compared to doses predicted using manufacturer-provided irradiator chamber exposure rates. Results The film dosimeter exhibited a photo-fluorescent response signal that was consistent and nearly linear in relationship to γ-radiation exposure over a wide dose range. The dosimeter response also showed negligible effects from dose fractionization and humidity. Significant disparities existed between manufacturer-provided chamber exposure rates and actual doses administered. Conclusion This study demonstrates the merit of utilizing dosimetric tools to validate the process of exposing dangerous and exotic biological agents to γ-radiation at high containment laboratories. The film dosimeter used in this study can be utilized to eliminate potential for improperly administering γ-radiation doses. PMID:21961968

  13. Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.

    PubMed

    Sahashi, K; Sakai, K; Mano, K; Hirose, G

    2003-09-01

    A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.

  14. A comparison of visual outcomes in three different types of monofocal intraocular lenses

    PubMed Central

    Shetty, Vijay; Haldipurkar, Suhas S; Gore, Rujuta; Dhamankar, Rita; Paik, Anirban; Setia, Maninder Singh

    2015-01-01

    AIM To compare the visual outcomes (distance and near) in patients opting for three different types of monofocal intraocular lens (IOL) (Matrix Aurium, AcrySof single piece, and AcrySof IQ lens). METHODS The present study is a cross-sectional analysis of secondary clinical data collected from 153 eyes (52 eyes in Matrix Aurium, 48 in AcrySof single piece, and 53 in AcrySof IQ group) undergoing cataract surgery (2011-2012). We compared near vision, distance vision, distance corrected near vision in these three types of lenses on day 15 (±3) post-surgery. RESULTS About 69% of the eyes in the Matrix Aurium group had good uncorrected distance vision post-surgery; the proportion was 48% and 57% in the AcrySof single piece and AcrySof IQ group (P=0.09). The proportion of eyes with good distance corrected near vision were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). Similarly, The proportion with good “both near and distance vision” were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). It was only the Matrix Aurium group which had significantly better both “distance and near vision” compared with the AcrySof IQ group (odds ratio: 5.87, 95% confidence intervals: 1.68 to 20.56). CONCLUSION Matrix Aurium monofocal lenses may be a good option for those patients who desire to have a good near as well as distance vision post-surgery. PMID:26682168

  15. A comparison of visual outcomes in three different types of monofocal intraocular lenses.

    PubMed

    Shetty, Vijay; Haldipurkar, Suhas S; Gore, Rujuta; Dhamankar, Rita; Paik, Anirban; Setia, Maninder Singh

    2015-01-01

    To compare the visual outcomes (distance and near) in patients opting for three different types of monofocal intraocular lens (IOL) (Matrix Aurium, AcrySof single piece, and AcrySof IQ lens). The present study is a cross-sectional analysis of secondary clinical data collected from 153 eyes (52 eyes in Matrix Aurium, 48 in AcrySof single piece, and 53 in AcrySof IQ group) undergoing cataract surgery (2011-2012). We compared near vision, distance vision, distance corrected near vision in these three types of lenses on day 15 (±3) post-surgery. About 69% of the eyes in the Matrix Aurium group had good uncorrected distance vision post-surgery; the proportion was 48% and 57% in the AcrySof single piece and AcrySof IQ group (P=0.09). The proportion of eyes with good distance corrected near vision were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). Similarly, The proportion with good "both near and distance vision" were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). It was only the Matrix Aurium group which had significantly better both "distance and near vision" compared with the AcrySof IQ group (odds ratio: 5.87, 95% confidence intervals: 1.68 to 20.56). Matrix Aurium monofocal lenses may be a good option for those patients who desire to have a good near as well as distance vision post-surgery.

  16. Economic considerations related to choice of intraocular lens (IOL) and posterior capsule opacification frequency - a comparison of three different IOLs.

    PubMed

    Cullin, Felix; Busch, Tobias; Lundström, Mats

    2014-03-01

    To evaluate the posterior capsule opacification (PCO) rates in three different modern standard intraocular lenses (IOL) and analyse the related cost. Retrospective study of medical records from 1527 patients who underwent uneventful cataract surgery by phacoemulsification with posterior chamber implantation of either AcrySof SN60 (n = 375), Akreos Adapt (n = 350) or Tecnis Acryl IOL (n = 801). All surgeries were performed by the same surgeon using the same surgical technique and equipment. Primary end-point was neodymium:yttrium-aluminium-garnet (Nd:YAG) capsulotomy for visual impairment secondary to PCO. Cost of IOL material and Nd:YAG capsulotomy for PCO was then evaluated and compared between the IOLs. Mean follow-up was 41.5 months, and the only statistically significant variable of developing PCO was IOL type and individual follow-up time. Nd:YAG capsulotomy was performed in 7.47% in the AcrySof group, 17.71% in the Akreos group and 3.75% in the Tecnis group. Average cost for Nd:YAG capsulotomy per surgery was €18.75 in the AcrySof SN60 group, €44.25 in the Akreos Adapt group and €9.25 in the Tecnis Acryl group. The combined cost of cataract surgery and PCO treatment was €9.81 higher in for the Akreos Adapt group than the other two combined. This retrospective study shows that the risk of PCO and Nd:YAG capsulotomy is significantly higher in hydrophilic Akreos IOL compared with both AcrySof and Tecnis hydrophobic IOLs. The increased risk of PCO in the hydrophilic IOL is related to higher total average costs for cataract surgery. © 2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.

  17. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR... Medicare Advantage (MA) Organizations § 495.204 Incentive payments to qualifying MA organizations for MA...

  18. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR... Medicare Advantage (MA) Organizations § 495.204 Incentive payments to qualifying MA organizations for MA...

  19. Spectral measurements of Terrestrial Mars Analogues: support for the ExoMars - Ma_Miss instrument

    NASA Astrophysics Data System (ADS)

    De Angelis, S.; De Sanctis, M. C.; Ammannito, E.; Di Iorio, T.; Carli, C.; Frigeri, A.; Capria, M. T.; Federico, C.; Boccaccini, A.; Capaccioni, F.; Giardino, M.; Cerroni, P.; Palomba, E.; Piccioni, G.

    2013-09-01

    The Ma_Miss (Mars Multispectral Imager for Subsurface Studies) instrument onboard of ExoMars 2018 mission to Mars will investigate the Martian subsoil down to a depth of 2 meters [1]. Ma_Miss is a miniaturized spectrometer, completely integrated within the drilling system of the ExoMars Pasteur rover; it will acquire spectra in the range 0.4-2.2μm, from the excavated borehole wall. The spectroscopic investigation of the subsurface materials will give us precious information about mineralogical, petrologic and geological processes, and will give insights about materials that have not been modified by surface processes such as erosion, weathering or oxidation. Spectroscopic measurements have been performed on Terrestrial Mars Analogues with the Ma_Miss laboratory model (breadboard). Moreover spectroscopic investigation of different sets of Terrestrial Mars Analogues is being carried on with different laboratory setups, as a support for the ExoMars-Ma_Miss instrument.

  20. Multi-MA reflex triode research.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Swanekamp, Stephen Brian; Commisso, Robert J.; Weber, Bruce V.

    The Reflex Triode can efficiently produce and transmit medium energy (10-100 keV) x-rays. Perfect reflexing through thin converter can increase transmission of 10-100 keV x-rays. Gamble II experiment at 1 MV, 1 MA, 60 ns - maximum dose with 25 micron tantalum. Electron orbits depend on the foil thickness. Electron orbits from LSP used to calculate path length inside tantalum. A simple formula predicts the optimum foil thickness for reflexing converters. The I(V) characteristics of the diode can be understood using simple models. Critical current dominates high voltage triodes, bipolar current is more important at low voltage. Higher current (2.5more » MA), lower voltage (250 kV) triodes are being tested on Saturn at Sandia. Small, precise, anode-cathode gaps enable low impedance operation. Sample Saturn results at 2.5 MA, 250 kV. Saturn dose rate could be about two times greater. Cylindrical triode may improve x-ray transmission. Cylindrical triode design will be tested at 1/2 scale on Gamble II. For higher current on Saturn, could use two cylindrical triodes in parallel. 3 triodes in parallel require positive polarity operation. 'Triodes in series' would improve matching low impedance triodes to generator. Conclusions of this presentation are: (1) Physics of reflex triodes from Gamble II experiments (1 MA, 1 MV) - (a) Converter thickness 1/20 of CSDA range optimizes x-ray dose; (b) Simple model based on electron orbits predicts optimum thickness from LSP/ITS calculations and experiment; (c) I(V) analysis: beam dynamics different between 1 MV and 250 kV; (2) Multi-MA triode experiments on Saturn (2.5 MA, 250 kV) - (a) Polarity inversion in vacuum, (b) No-convolute configuration, accurate gap settings, (c) About half of current produces useful x-rays, (d) Cylindrical triode one option to increase x-ray transmission; and (3) Potential to increase Saturn current toward 10 MA, maintaining voltage and outer diameter - (a) 2 (or 3) cylindrical triodes in parallel, (b

  1. [60]Fullerene Displacement from (Dihapto-Buckminster-Fullerene) Pentacarbonyl Tungsten(0): An Experiment for the Inorganic Chemistry Laboratory, Part II

    ERIC Educational Resources Information Center

    Cortes-Figueroa, Jose E.; Moore-Russo, Deborah A.

    2006-01-01

    The kinetics experiments on the ligand-C[subscript 60] exchange reactions on (dihapto-[60]fullerene) pentacarbonyl tungsten(0), ([eta][superscript 2]-C[subscript 60])W(CO)[subscript 5], form an educational activity for the inorganic chemistry laboratory that promotes graphical thinking as well as the understanding of kinetics, mechanisms, and the…

  2. Pigment dispersion and chronic intraocular pressure elevation after sulcus placement of 3-piece acrylic intraocular lens.

    PubMed

    Almond, M Camille; Wu, Michael C; Chen, Philip P

    2009-12-01

    A 55-year-old man had phacoemulsification and implantation of a 3-piece acrylic intraocular lens (IOL) (AcrySof MA60AC) in the right eye. One month postoperatively, the intraocular pressure (IOP) was 48 mm Hg and peripheral transillumination defects were noted in the iris circumferentially, with the IOL optic edge visible as a silhouette. Gonioscopy showed dense pigmentation of the trabecular meshwork in the right eye, but in the left eye, only mild trabecular meshwork pigment was seen, along with a concave peripheral iris insertion. At 21 months, the right eye required 3 medications for IOP control. While pigment dispersion has been widely reported after placement of 1-piece acrylic IOLs in the ciliary sulcus, we conclude that in susceptible individuals with a concave peripheral iris insertion, pigment dispersion can occur with sulcus placement of a 3-piece acrylic model despite its thinner optic and angulated haptics.

  3. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... I test components, in-process materials, and finished PET drug products? 212.60 Section 212.60 Food... materials, and finished PET drug products? (a) Testing procedures. Each laboratory used to conduct testing of components, in-process materials, and finished PET drug products must have and follow written...

  4. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for qualifying MA-EPs and qualifying MA...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... methodological proposal for estimating the portion of each qualifying MA EP's salary or revenue attributable to... enrollees of the MA organization in the payment year. The methodological proposal— (i) Must be approved by... account for the MA-enrollee related Part B practice costs of the qualifying MA EP. (iii) Methodological...

  5. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for qualifying MA-EPs and qualifying MA...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... methodological proposal for estimating the portion of each qualifying MA EP's salary or revenue attributable to... enrollees of the MA organization in the payment year. The methodological proposal— (i) Must be approved by... account for the MA-enrollee related Part B practice costs of the qualifying MA EP. (iii) Methodological...

  6. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... I test components, in-process materials, and finished PET drug products? 212.60 Section 212.60 Food... finished PET drug products? (a) Testing procedures. Each laboratory used to conduct testing of components, in-process materials, and finished PET drug products must have and follow written procedures for the...

  7. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... I test components, in-process materials, and finished PET drug products? 212.60 Section 212.60 Food... finished PET drug products? (a) Testing procedures. Each laboratory used to conduct testing of components, in-process materials, and finished PET drug products must have and follow written procedures for the...

  8. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... I test components, in-process materials, and finished PET drug products? 212.60 Section 212.60 Food... finished PET drug products? (a) Testing procedures. Each laboratory used to conduct testing of components, in-process materials, and finished PET drug products must have and follow written procedures for the...

  9. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... I test components, in-process materials, and finished PET drug products? 212.60 Section 212.60 Food... finished PET drug products? (a) Testing procedures. Each laboratory used to conduct testing of components, in-process materials, and finished PET drug products must have and follow written procedures for the...

  10. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  11. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  12. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  13. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  14. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  15. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  16. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  17. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  18. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  19. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull, MA to Race Point, MA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a... the east coast of Massachusetts from the easternmost radio tower at Hull, charted in approximate...

  20. The Otis Weather Test Facility at Otis ANGB, Falmouth, MA : an aviation weather resource

    DOT National Transportation Integrated Search

    2004-10-06

    The Otis Weather Test Facility (WTF) is located on the US Air National Guard Base, Cape Cod, MA. The Facility was originally established by the US Air Force Cambridge Research Laboratory [now Air Force Research Laboratory (AFRL)] in 1974 to develop a...

  1. MaRIE: Probing Dynamic Processes in Soft Materials Using Advanced Light Sources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sykora, Milan; Kober, Edward Martin

    Los Alamos National Laboratory has developed a concept for a new research facility, MaRIE: Matter-Radiation Interactions in Extremes. The key motivation for MaRIE is to develop new experimental capabilities needed to fill the existing gaps in our fundamental understanding of materials important for key National Nuclear Security Agency (NNSA) goals. MaRIE will bring two major new capabilities: (a) the ability to characterize the meso- and microstructure of materials in bulk as well as local dynamic response characteristics, and (b) the ability to characterize how this microstructure evolves under NNSA-relevant conditions and impacts the material’s performance in this regime.

  2. Roadmap to MaRIE March 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris William

    Los Alamos National Laboratory’s proposed MaRIE facility is slated to introduce the world’s highest energy hard x-ray free electron laser (XFEL). As the light source for the Matter-Radiation Interactions in Extremes experimental facility (MaRIE), the 42-keV XFEL, with bursts of x-ray pulses at gigahertz repetition for studying fast dynamical processes, will help accelerate discovery and design of the advanced materials needed to meet 21st-century national security and energy security challenges. Yet the science of free-electron lasers has a long and distinguished history at Los Alamos National Laboratory (LANL), where for nearly four decades Los Alamos scientists have been performing research,more » design, development, and collaboration work in FEL science. The work at Los Alamos has evolved from low-gain amplifier and oscillator FEL development to highbrightness photoinjector development, and later, self-amplified spontaneous emission (SASE) and high-gain amplifier FEL development.« less

  3. The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kippen, Karen Elizabeth; Montoya, Donald Raymond

    The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) andmore » its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.« less

  4. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128.

    PubMed

    Kim, Dong-Seon; Kim, Seung-Hyung; Kim, Bok-Kyu; Yang, Min Cheol; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma. Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges. MA and MA128 were orally administered 6 times a week for 4 weeks. At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis. We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma. In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-γ), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells. The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus.

  5. MA_MISS and terrestrial analogues for Mars

    NASA Astrophysics Data System (ADS)

    De Sanctis, M. C.; De Angelis, S.; Ammannito, E.; Di Iorio, T.; Carli, C.; Frigeri, A.; Boccaccini, A.; Battistelli, E.; Mugnolo, R.; MA MISS Team

    2012-09-01

    The MA_MISS instrument (Mars Multispectral Imager for Subsurface Studies) is a VIS-NIR spectrometer devoted to study the Martian subsoil within the ExoMars mission. This miniaturized spectrometer is integrated in drilling system of the ExoMars Pasteur Rover, and will investigate the Martian subsoil down to 2 m, in the spectral range 0.4 - 2.2 μm [1,2]. It will provide important information regarding the composition and mineralogy of the Martian subsoil, whose materials are expected to be less altered by erosion and other exogenous processes than surface rocks. With a view to doing laboratory spectroscopic measurements with the instrument breadboard, we performed preliminary laboratory measurements on Mars analogues using a spectrophotometer coupled with a goniometer.

  6. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  7. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  8. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  9. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  10. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  11. MA_MISS: Mars Multispectral Imager for Subsurface Studies

    NASA Astrophysics Data System (ADS)

    De Sanctis, M. C.; Coradini, A.; Ammannito, E.; Boccaccini, A.; Di Iorio, T.; Battistelli, E.; Capanni, A.

    2012-04-01

    through the different elements of the Drill by means of fiber optics and an optical rotary joint implemented in the roto-translation group of the Drill. Ma_Miss Optical Head has been tested in the breadboard to capture the diffused light from the observed target and transfer the signal to a laboratory spectrometer for analysis. The Optical Head of Ma_Miss has been tested after integration in ExoMars Drill. The drilling experiment has been carried out in realistic media (tuff, red brick). The test shows good performance of Optical Head illumination capability and of the window cleanliness during the drilling. Illumination spot is focused at the nominal distance of 0.2 mm from the sapphire window. During the ExoMars Pasteur Rover mission, the Ma_Miss experiment will allow collecting valuable data of the drilled stratigraphic column, will document "in-situ" the nature of the samples that will be delivered to the Pasteur Laboratory and will be able to identify hydrated minerals, sedimentary materials and different kind of diagnostic materials of Martian subsurface.

  12. In vivo chromatic aberration in eyes implanted with intraocular lenses.

    PubMed

    Pérez-Merino, Pablo; Dorronsoro, Carlos; Llorente, Lourdes; Durán, Sonia; Jiménez-Alfaro, Ignacio; Marcos, Susana

    2013-04-12

    To measure in vivo and objectively the monochromatic aberrations at different wavelengths, and the chromatic difference of focus between green and infrared wavelengths in eyes implanted with two models of intraocular lenses (IOL). EIGHTEEN EYES PARTICIPATED IN THIS STUDY: nine implanted with Tecnis ZB99 1-Piece acrylic IOL and nine implanted with AcrySof SN60WF IOL. A custom-developed laser ray tracing (LRT) aberrometer was used to measure the optical aberrations, at 532 nm and 785 nm wavelengths. The monochromatic wave aberrations were described using a fifth-order Zernike polynomial expansion. The chromatic difference of focus was estimated as the difference between the equivalent spherical errors corresponding to each wavelength. Wave aberration measurements were highly reproducible. Except for the defocus term, no significant differences in high order aberrations (HOA) were found between wavelengths. The average chromatic difference of focus was 0.46 ± 0.15 diopters (D) in the Tecnis group, and 0.75 ± 0.12 D in the AcrySof group, and the difference was statistically significant (P < 0.05). Chromatic difference of focus in the AcrySof group was not statistically significantly different from the Longitudinal chromatic aberration (LCA) previously reported in a phakic population (0.78 ± 0.16 D). The impact of LCA on retinal image quality (measured in terms of Strehl ratio) was drastically reduced when considering HOA and astigmatism in comparison with a diffraction-limited eye, yielding the differences in retinal image quality between Tecnis and AcrySof IOLs not significant. LRT aberrometry at different wavelengths is a reproducible technique to evaluate the chromatic difference of focus objectively in eyes implanted with IOLs. Replacement of the crystalline lens by the IOL did not increase chromatic difference of focus above that of phakic eyes in any of the groups. The AcrySof group showed chromatic difference of focus values very similar to physiological

  13. Power and Professionalism: Reconstruction of Medical Educators' Practice by Way of a MA(Ed).

    ERIC Educational Resources Information Center

    Elmer, Roger

    England's King Alfred's College offers a MA(Ed) professional enquiry for teachers. In 1997, four medical doctors expressed interest in developing educational perspectives. Critical examination of the MA(Ed) indicated close parallels with the work of medical educators. The congruity was in an educational philosophy: people's internal values and…

  14. 17 CFR 240.15Ba1-5 - Amendments to Form MA and Form MA-I.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Amendments to Form MA and Form MA-I. 240.15Ba1-5 Section 240.15Ba1-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Amendments to Form MA and Form MA-I. (a) When amendment is required—Form MA. A registered municipal advisor...

  15. Designs and Plans for MAIZE: a 1 MA LTD-Driven Z-Pinch

    NASA Astrophysics Data System (ADS)

    Gilgenbach, R. M.; Gomez, M. R.; Zier, J.; Tang, W.; French, D. M.; Hoff, B. W.; Jordan, N.; Cruz, E.; Lau, Y. Y.; Fowler-Guzzardo, T.; Meisel, J.; Mazarakis, M. G.; Cuneo, M. E.; Johnston, M. D.; Mehlhorn, T. A.; Kim, A. A.; Sinebryukhov, V. A.

    2007-11-01

    We present designs and experimental plans of the first 1 MA z-pinch in the USA to be driven by a Linear Transformer Driver (LTD). The Michigan Accelerator for Inductive Z-pinch Experiments, (MAIZE), is based on the LTD developed at the Institute for High Current Electronics, utilizing 80 capacitors and 40 spark gap switches to deliver a 1 MA, 100 kV pulse with <100 ns risetime. Designs will be presented of a low-inductance MITL terminated in a wire-array z-pinch. Initial, planned experiments will evaluate the LTD driving time-changing inductance of imploding 4-16 wire-array z-pinches. Wire ablation dynamics, axial-correlations and instability development will be explored. *This work was supported by U. S. DoE through Sandia National Laboratories award number 240985 to the University of Michigan. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  16. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

    PubMed

    Matsuhashi, Tetsuro; Sato, Takeya; Kanno, Shin-Ichiro; Suzuki, Takehiro; Matsuo, Akihiro; Oba, Yuki; Kikusato, Motoi; Ogasawara, Emi; Kudo, Tai; Suzuki, Kosuke; Ohara, Osamu; Shimbo, Hiroko; Nanto, Fumika; Yamaguchi, Hiroaki; Saigusa, Daisuke; Mukaiyama, Yasuno; Watabe, Akiko; Kikuchi, Koichi; Shima, Hisato; Mishima, Eikan; Akiyama, Yasutoshi; Oikawa, Yoshitsugu; Hsin-Jung, H O; Akiyama, Yukako; Suzuki, Chitose; Uematsu, Mitsugu; Ogata, Masaki; Kumagai, Naonori; Toyomizu, Masaaki; Hozawa, Atsushi; Mano, Nariyasu; Owada, Yuji; Aiba, Setsuya; Yanagisawa, Teruyuki; Tomioka, Yoshihisa; Kure, Shigeo; Ito, Sadayoshi; Nakada, Kazuto; Hayashi, Ken-Ichiro; Osaka, Hitoshi; Abe, Takaaki

    2017-06-01

    Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favorable effects in the clinic. We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). MA-5 increased ATP, rescued mitochondrial disease fibroblasts and prolonged the life span of the disease model "Mitomouse" (JASN, 2016). To investigate the potential of MA-5 on various mitochondrial diseases, we collected 25 cases of fibroblasts from various genetic mutations and cell protective effect of MA-5 and the ATP producing mechanism was examined. 24 out of the 25 patient fibroblasts (96%) were responded to MA-5. Under oxidative stress condition, the GDF-15 was increased and this increase was significantly abrogated by MA-5. The serum GDF-15 elevated in Mitomouse was likewise reduced by MA-5. MA-5 facilitates mitochondrial ATP production and reduces ROS independent of ETC by facilitating ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60. MA-5 reduced mitochondria fragmentation, restores crista shape and dynamics. MA-5 has potential as a drug for the treatment of various mitochondrial diseases. The diagnostic use of GDF-15 will be also useful in a forthcoming MA-5 clinical trial. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  17. Scaling of X pinches from 1 MA to 6 MA.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bland, Simon Nicholas; McBride, Ryan D.; Wenger, David Franklin

    This final report for Project 117863 summarizes progress made toward understanding how X-pinch load designs scale to high currents. The X-pinch load geometry was conceived in 1982 as a method to study the formation and properties of bright x-ray spots in z-pinch plasmas. X-pinch plasmas driven by 0.2 MA currents were found to have source sizes of 1 micron, temperatures >1 keV, lifetimes of 10-100 ps, and densities >0.1 times solid density. These conditions are believed to result from the direct magnetic compression of matter. Physical models that capture the behavior of 0.2 MA X pinches predict more extreme parametersmore » at currents >1 MA. This project developed load designs for up to 6 MA on the SATURN facility and attempted to measure the resulting plasma parameters. Source sizes of 5-8 microns were observed in some cases along with evidence for high temperatures (several keV) and short time durations (<500 ps).« less

  18. Sulfoxidation Regulation of Musa acuminata Calmodulin (MaCaM) Influences the Functions of MaCaM-Binding Proteins.

    PubMed

    Jiang, Guoxiang; Wu, Fuwang; Li, Zhiwei; Li, Taotao; Gupta, Vijai Kumar; Duan, Xuewu; Jiang, Yueming

    2018-06-01

    Sulfoxidation of methionine in proteins by reactive oxygen species can cause conformational alteration or functional impairment, and can be reversed by methionine sulfoxide reductase (Msr). Currently, only a few potential Msr substrates have been confirmed in higher plants. Here, we investigated Msr-mediated sulfoxidation regulation of calmodulin (CaM) and its underlying biological significance in relation to banana fruit ripening and senescence. Expression of MaCaM1 and MaMsrA7 was up-regulated with increased ripening and senescence. We verified that MaCaM1 interacts with MaMsrA7 in vitro and in vivo, and sulfoxidated MaCaM1 could be partly repaired by MaMsrA7 (MaMsrA7 reduces oxidized residues Met77 and Met110 in MaCaM1). Furthermore, we investigated two known CaM-binding proteins, catalase (MaCAT1) and MaHY5-1. MaHY5-1 acts as a transcriptional repressor of carotenoid biosynthesis-related genes (MaPSY1, MaPSY2 and MaPSY3) in banana fruit. MaCaM1 could enhance the catalytic activity of MaCAT1 and the transcriptional repression activity of MaHY5-1 toward MaPSY2. Mimicked sulfoxidation in MaCaM1 did not affect the physical interactions of the protein with MaHY5-1 and MaCAT1, but reduced the catalytic activity of MaCAT1 and the transcriptional repression activity of MaHY5-1. Our data suggest that sulfoxidation modification in MaCaM1 by MaMsrA7 regulates antioxidant response and gene transcription, thereby being involved in regulation of ripening and senescence of banana fruit.

  19. Gondwanaland from 650-500 Ma assembly through 320 Ma merger in Pangea to 185-100 Ma breakup: supercontinental tectonics via stratigraphy and radiometric dating

    NASA Astrophysics Data System (ADS)

    Veevers, J. J.

    2004-12-01

    Gondwanaland lasted from the 650-500 Ma (late Neoproterozoic-Cambrian) amalgamation of African and South American terranes to Antarctica-Australia-India through 320 Ma (mid-Carboniferous) merging with Laurussia in Pangea to breakup from 185 to 100 Ma (Jurassic and Early Cretaceous). Gondwanaland straddled the equator at 540 Ma, lay wholly in the Southern Hemisphere by 350 Ma, and then rotated clockwise so that at 250 Ma Australia reached the S pole and Africa the equator. By initial breakup of Pangea at 185 Ma, Gondwanaland had moved northward such that North Africa reached 35°N. The first clear picture of Gondwanaland, in the Cambrian, shows the assembly of continents with later Laurentian, European and Asian terranes along the "northern" margin, and with a trench along the "western" and "southern" margins, reflected by a 10,000-km-long chain of 530-500 Ma granites. The interior was crossed by the Prydz-Leeuwin and Mozambique Orogenic Belts. The shoreline lapped the flanks of uplifts generated during this complex terminal Pan-Gondwanaland (650-500 Ma) deformation, which endowed Gondwanaland with a thick, buoyant crust and lithosphere and a nonmarine siliciclastic facies. During the Ordovician, terranes drifted from Africa as the first of many transfers of material to the "northern" continents. Central Australia was crossed by the sea, and the eastern margin and ocean floor were flooded by grains of quartz (and 600-500 Ma zircon) from Antarctica. Ice centres in North Africa and southern South America/Africa waxed and waned in the latest Ordovician, Early Silurian, latest Devonian, and Early Carboniferous. In the mid-Carboniferous, Laurussia and Gondwanaland merged in the composite called Pangea by definitive right-lateral contact along the Variscan suture, with collisional stress and subsequent uplift felt as far afield as Australia. Ice sheets developed on the tectonic uplands of Gondwanaland south of 30°S. In the Early Permian, the self-induced heat beneath

  20. Characterization and expression profiles of MaACS and MaACO genes from mulberry (Morus alba L.)*

    PubMed Central

    Liu, Chang-ying; Lü, Rui-hua; Li, Jun; Zhao, Ai-chun; Wang, Xi-ling; Diane, Umuhoza; Wang, Xiao-hong; Wang, Chuan-hong; Yu, Ya-sheng; Han, Shu-mei; Lu, Cheng; Yu, Mao-de

    2014-01-01

    1-Aminocyclopropane-1-carboxylic acid synthase (ACS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) are encoded by multigene families and are involved in fruit ripening by catalyzing the production of ethylene throughout the development of fruit. However, there are no reports on ACS or ACO genes in mulberry, partly because of the limited molecular research background. In this study, we have obtained five ACS gene sequences and two ACO gene sequences from Morus Genome Database. Sequence alignment and phylogenetic analysis of MaACO1 and MaACO2 showed that their amino acids are conserved compared with ACO proteins from other species. MaACS1 and MaACS2 are type I, MaACS3 and MaACS4 are type II, and MaACS5 is type III, with different C-terminal sequences. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) expression analysis showed that the transcripts of MaACS genes were strongly expressed in fruit, and more weakly in other tissues. The expression of MaACO1 and MaACO2 showed different patterns in various mulberry tissues. MaACS and MaACO genes demonstrated two patterns throughout the development of mulberry fruit, and both of them were strongly up-regulated by abscisic acid (ABA) and ethephon. PMID:25001221

  1. The 300 mA SRF ERL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ben-Zvi, Ilan

    Energy Recovery Linacs (ERL) are important for a variety of applications, from high-power Free-Electron Lasers (FEL) to polarized-electron polarized-proton colliders. The ERL current is arguably the most important characteristic of ERLs for such applications. With that in mind, the Collider-Accelerator Department at Brookhaven National Laboratory embarked on the development of a 300 mA ERL to serve as an R and D test-bed for high-current ERL technologies. These include high-current, extremely well damped superconducting accelerating cavities, high-current superconducting laser-photocathode electron guns and high quantum-efficiency photocathodes. In this presentation I will cover these ERL related developments.

  2. Earth-Moon Impacts at 300 Ma and 500 Ma Ago

    NASA Technical Reports Server (NTRS)

    Zellner, N. E. B.; Delano, J. W.; Swindle, T. D.; Barra, F.; Whittet, D. C. B.; Spudis, P. D.

    2005-01-01

    Impact events have played an important role in the evolution of planets and small bodies in the Solar System. Meteorites, lunar melt rocks, and lunar impact glasses provide important information about the geology of the parent body and the age of the impacting episodes. Over 2400 impact glasses from 4 Apollo regolith samples have been geochemically analyzed and a subset has been dated by the (40)Ar/(39)Ar method. New results, consistent with 2 break-ups in the Asteroid Belt, are presented here. Our previous study reported that (40)Ar/(39)Ar ages from 9 impact glasses showed that the Moon experienced significant impacts at approx. 800 Ma and at approx. 3800 Ma ago, somewhere in the vicinity of the Apollo 16 landing site. Additionally, reported on Apollo 12 samples with ages around 800 Ma, together implying global bombardment events. New data on 7 glasses from regolith sample 66041,127 show that the Moon also experienced impact events at approx. 300 Ma and > 500 Ma ago, which may coincide with the break-ups in the Asteroid Belt of the L- and H-chrondrite parent bodies. Since meteoritic evidence for these breakups has been found on Earth, it follows that evidence should be found in lunar samples as well. Additional information is included in the original extended abstract.

  3. Discovery and utilization of sorghum genes (Ma5/Ma6)

    DOEpatents

    Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

    2012-11-13

    Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

  4. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (iii) Methodological proposals must be submitted to CMS by June of the payment year and must be... the payment year. (4) CMS requires the qualifying MA organization to develop a methodological proposal... MA organization in the payment year. The methodological proposal— (i) Must be approved by CMS; and...

  5. Clinical analysis of anti-Ma2-associated encephalitis.

    PubMed

    Dalmau, Josep; Graus, Francesc; Villarejo, Alberto; Posner, Jerome B; Blumenthal, Deborah; Thiessen, Brian; Saiz, Albert; Meneses, Patricio; Rosenfeld, Myrna R

    2004-08-01

    Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis, and therefore may be unrecognized. To facilitate its diagnosis we report a comprehensive clinical analysis of 38 patients with anti-Ma2 encephalitis. Thirty-four (89%) patients presented with isolated or combined limbic, diencephalic or brainstem dysfunction, and four with other syndromes. Considering the clinical and MRI follow-up, 95% of the patients developed limbic, diencephalic or brainstem encephalopathy. Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF hypocretin. Additional hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the patients. Eye movement abnormalities were prominent in 92% of the patients with brainstem dysfunction, but those with additional limbic or diencephalic deficits were most affected; 60% of these patients had vertical gaze paresis that sometimes evolved to total external ophthalmoplegia. Three patients developed atypical parkinsonism, and two a severe hypokinetic syndrome with a tendency to eye closure and dramatic reduction of verbal output. Neurological symptoms preceded the tumour diagnosis in 62% of the patients. Brain MRI abnormalities were present in 74% of all patients and 89% of those with limbic or diencephalic dysfunction. Among the 34 patients with cancer, 53% had testicular germ-cell tumours. Two patients without evidence of cancer had testicular microcalcification and one cryptorchidism, risk factors for testicular germ-cell tumours. After neurological syndrome development, 17 of 33 patients received oncological treatment (nine also immunotherapy), 10 immunotherapy alone, and six no treatment. Overall, 33% of the patients had neurological improvement, three with complete recovery; 21% had long-term stabilization, and 46% deteriorated. Features

  6. Evaluation of rotation and visual outcomes after implantation of monofocal and multifocal toric intraocular lenses.

    PubMed

    Garzón, Nuria; Poyales, Francisco; de Zárate, Begoña Ortíz; Ruiz-García, Jose Luis; Quiroga, Juan Antonio

    2015-02-01

    To evaluate rotational stability and its influence on postoperative visual acuity of different monofocal and multifocal toric intraocular lenses (IOLs). A prospective interventional study was designed. Ninety-one patients with a mean age of 71.65 ± 11.82 years were implanted with toric IOLs after phacoemulsification. Three monofocal toric IOLs (the Lentis LT [Oculentis, Berlin, Germany], enVista [Bausch & Lomb, Rochester, NY], and AcrySof IQ [Alcon Laboratories, Inc., Fort Worth, TX]) and one multifocal toric IOL (AcrySof IQ ReSTOR; Alcon Laboratories, Inc.) were implanted. Preoperative and postoperative images were taken to calculate the misalignment due to the marking method. To evaluate rotation in the different follow-up visits, another photograph was taken 1 hour and 1, 7 and 30 days postoperatively. Refraction, uncorrected distance visual acuity (UDVA), and corrected distance visual acuity were measured 30 days postoperatively. Postoperative UDVA was 0.1 logMAR or better in 64.6% of eyes implanted with monofocal IOLs and 46.4% of eyes implanted with multifocal IOLs. The enVista toric IOL showed the best UDVA compared to the other monofocal IOLs, with 81% of eyes with 0.1 logMAR or better. The mean misalignment in the total group studied was 0.07° ± 0.60°; 69.6% of monofocal IOLs and 67.9% of multifocal IOLs showed less than 5° of rotation. A correlation was found between postoperative UDVA and rotation in the monofocal and multifocal IOLs implanted (r = 0.439 [P < .011] and = 0.787 [P = .001], respectively). At 1 month postoperatively, UDVA was slightly more affected by IOL rotation in multifocal than monofocal toric IOLs. The marking method was also effective. Copyright 2015, SLACK Incorporated.

  7. The Ma_Miss instrument performance, I: Analysis of rocks powders by Martian VNIR spectrometer

    NASA Astrophysics Data System (ADS)

    De Angelis, Simone; De Sanctis, Maria Cristina; Ammannito, Eleonora; Carli, Cristian; Di Iorio, Tatiana; Altieri, Francesca

    2014-10-01

    The ExoMars/Ma_Miss instrument is a miniaturized spectrometer that will observe the Martian subsoil in the visible and near infrared range (VNIR, 0.4-2.2 μm) with high spatial resolution, 120 μm. It will be integrated in the Drilling system of the Pasteur Rover of the ExoMars 2018 mission, and will acquire reflectance spectra of the borehole wall performed by the Drill, at various depths down to 2 m. The laboratory breadboard instrument consists of the main subsystems: illumination system, optical fibres for illumination and signal collection, and optical elements for light focusing. It has been interfaced with a commercial spectrometer, the FieldSpec Pro©. The primary aim of this work is to compare the VNIR measurements and spectral parameters derived from the spectra acquired with the Ma_Miss breadboard and with a second laboratory setup. Reflectance spectra have been acquired on a set of six rock powder samples representative of Martian soil. Nine different grain size ranges of each sample have been measured with the breadboard and five spectral parameters were used to explore the Ma_Miss spectra. Those data were compared with spectra acquired by the FieldSpec Pro® coupled with a goniometer. The analyses of these spectral parameters evidence the correlation between the VNIR continuum slope and the grain size, and the correlation between the reflectance and the grain size; both the parameters tend to decrease as the grain size increases. The trends observed with Ma_Miss breadboard for NIR and VNIR slopes and for the reflectance are clearly consistent with the trends observed with the spectro-goniometer setup, although small differences are seen that can be explained with the different viewing geometries of the two instruments. Ma_Miss proves to have great capabilities for extracting spectroscopic information to constrain the mineralogy and some physical parameters of the analysed material.

  8. MaRIE: A facility for time-dependent materials science at the mesoscale

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris William; Kippen, Karen Elizabeth

    To meet new and emerging national security issues the Laboratory is stepping up to meet another grand challenge—transitioning from observing to controlling a material’s performance. This challenge requires the best of experiment, modeling, simulation, and computational tools. MaRIE is the Laboratory’s proposed flagship experimental facility intended to meet the challenge.

  9. Comparison between bilateral implantation of a trifocal intraocular lens and blended implantation of two bifocal intraocular lenses

    PubMed Central

    Vilar, César; Hida, Wilson Takashi; de Medeiros, André Lins; Magalhães, Klayny Rafaella Pereira; de Moraes Tzelikis, Patrick Frensel; Chaves, Mario Augusto Pereira Dias; Motta, Antônio Francisco Pimenta; Carricondo, Pedro Carlos; Alves, Milton Ruiz; Nosé, Walton

    2017-01-01

    Purpose To compare visual outcomes and performance between bilateral implantation of a diffractive trifocal intraocular lens (IOL) Acrysof®PanOptix® TFNT00 and blended implantation of two different near add power bifocal IOLs: Acrysof® Restor® SV25T0 in dominant eye and Acrysof® Restor® SN6AD1 in the nondominant eye. Methods This prospective, nonrandomized, consecutive and comparative study assessed 20 patients (40 eyes) who had bilateral cataract surgery performed using the IOLs described. Patients were divided into groups, bilateral trifocal implant and blended implant. Evaluation included measurement of binocular uncorrected and corrected distance visual acuity at 4 m (UDVA, CDVA) and uncorrected intermediate (60 cm) and near (at 40 cm) visual acuity; contrast sensitivity (CS) and visual defocus curve. Results Postoperative CDVA comparison showed no statistical significance between groups. UDVA was significantly better in the trifocal groups. Under photopic conditions, the trifocal group had better CS in higher frequencies with and without glare. The binocular defocus curve demonstrated a trifocal behavior in both groups, with the bilateral trifocal group exhibiting better performance for intermediate vision. Conclusion Both lens combinations were able to provide good near, intermediate and distance vision, with the trifocal group showing significantly better performance at intermediate distances and better CS under photopic conditions. PMID:28814826

  10. MoMaS reactive transport benchmark using PFLOTRAN

    NASA Astrophysics Data System (ADS)

    Park, H.

    2017-12-01

    MoMaS benchmark was developed to enhance numerical simulation capability for reactive transport modeling in porous media. The benchmark was published in late September of 2009; it is not taken from a real chemical system, but realistic and numerically challenging tests. PFLOTRAN is a state-of-art massively parallel subsurface flow and reactive transport code that is being used in multiple nuclear waste repository projects at Sandia National Laboratories including Waste Isolation Pilot Plant and Used Fuel Disposition. MoMaS benchmark has three independent tests with easy, medium, and hard chemical complexity. This paper demonstrates how PFLOTRAN is applied to this benchmark exercise and shows results of the easy benchmark test case which includes mixing of aqueous components and surface complexation. Surface complexations consist of monodentate and bidentate reactions which introduces difficulty in defining selectivity coefficient if the reaction applies to a bulk reference volume. The selectivity coefficient becomes porosity dependent for bidentate reaction in heterogeneous porous media. The benchmark is solved by PFLOTRAN with minimal modification to address the issue and unit conversions were made properly to suit PFLOTRAN.

  11. Three-year incidence of Nd:YAG capsulotomy and posterior capsule opacification and its relationship to monofocal acrylic IOL biomaterial: a UK Real World Evidence study.

    PubMed

    Ursell, Paul G; Dhariwal, Mukesh; Majirska, Katarina; Ender, Frank; Kalson-Ray, Shoshannah; Venerus, Alessandra; Miglio, Cristiana; Bouchet, Christine

    2018-06-11

    To evaluate 3-year incidence of Nd:YAG capsulotomy and PCO and compare the effect of different IOL materials. Data were retrospectively collected from seven UK ophthalmology clinics using Medisoft electronic medical records. Eyes from patients ≥65 years undergoing cataract surgery with implantation of acrylic monofocal IOLs during 2010-2013 and 3-year follow-up were analysed. Nd:YAG capsulotomy and PCO incidence proportions were reported for 3 IOL cohorts: AcrySof, other hydrophobic and hydrophilic acrylic IOLs. Unadjusted/adjusted odds ratios (OR) of Nd:YAG capsulotomy were calculated through logistic regression for non-AcrySof cohorts versus AcrySof. A sub-group analysis in single-piece IOLs (>90% of sample eyes) was also performed. The AcrySof cohort included 13,329 eyes, non-AcrySof hydrophobic 19,025 and non-AcrySof hydrophilic 19,808. The 3-year Nd:YAG capsulotomy incidence (95% CI) for AcrySof (2.4%, 2.2-2.7%) was approximately two times lower than non-AcrySof hydrophobic IOLs (4.4%, 4.1-4.7%) and approximately fourfold lower than non-AcrySof hydrophilic IOLs (10.9%, 10.5-11.3%). Trends were similar in PCO incidence (AcrySof: 4.7%; non-AcrySof hydrophobic: 6.3%; non-AcrySof hydrophilic: 14.8%). Also in the analysis restricted to single-piece IOLs, the pattern remained (2.4% vs 5.1% vs. 10.9%, respectively). Adjusted regression analysis showed a approximately two and fivefold increased odds of Nd:YAG for non-AcrySof hydrophobic and hydrophilic acrylic IOLs respectively vs. AcrySof IOLs. Nd:YAG capsulotomy ORs were similar and remained statistically significant in the single-piece IOL sub-group. Real-world evidence shows that within 3 years following implantation, AcrySof IOLs are significantly superior in reducing Nd:YAG capsulotomy and PCO incidence compared to other hydrophilic and hydrophobic acrylic IOLs.

  12. 62ma6-55

    NASA Image and Video Library

    2012-02-02

    62-MA6-55 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury Atlas 6 (MA-6) spaceflight, poses for a photo with the Mercury "Friendship 7" spacecraft during preflight activities. Photo credit: NASA

  13. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  14. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  15. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  16. Mapping Nearby Galaxies at APO: The MaNGA IFU Galaxy Survey

    NASA Astrophysics Data System (ADS)

    Law, David R.; MaNGA Team

    2014-01-01

    MaNGA is a new survey that will begin in August 2014 as part of SDSS-IV with the aim of obtaining integral-field spectroscopy for an unprecedented sample of 10,000 nearby galaxies. MaNGA's key goals are to understand the "life cycle" of present day galaxies from imprinted clues of their birth and assembly, through their ongoing growth via star formation and merging, to their death from quenching at late times. To achieve these goals, MaNGA will channel the impressive capabilities of the SDSS-III BOSS spectrographs in a fundamentally new direction by marshaling the unique power of 2D spectroscopy. MaNGA will deploy 17 pluggable Integral Field Units (IFUs) made by grouping fibers into hexagonal bundles ranging from 19 to 127 fibers each. The spectra obtained by MaNGA will cover the wavelength range 3600-10,000 Angstroms (with a velocity resolution of ~ 60 km/s) and will characterize the internal composition and the dynamical state of a sample of 10,000 galaxies with stellar masses greater than 10^9 Msun and an average redshift of z ~ 0.03. Such IFU observations enable a leap forward because they provide an added dimension to the information available for each galaxy. MaNGA will provide two-dimensional maps of stellar velocity and velocity dispersion, mean stellar age and star formation history, stellar metallicity, element abundance ratio, stellar mass surface density, ionized gas velocity, ionized gas metallicity, star formation rate, and dust extinction for a statistically powerful sample. This legacy dataset will address urgent questions in our understanding of galaxy formation, including 1) The formation history of galaxy subcomponents, including the disk, bulge, and dark matter halo, 2) The nature of present-day galaxy growth via merging and gas accretion, and 3) The processes responsible for terminating star formation in galaxies. Finally, MaNGA will also play a vital role in the coming era of advanced IFU instrumentation, serving as the low-z anchor for

  17. FE-60 and the evolution of eucrites

    NASA Technical Reports Server (NTRS)

    Shukolyukov, A.; Lugmair, G. W.

    1993-01-01

    We have recently presented evidence for the existence of live Fe-60 in the early solar system. This evidence comes from observations of 2.4 to 50 epsilon unit (1 part in 10(exp 4)) relative excesses of Ni-60 measured in samples from the eucrite Chervony Kut (CK). These isotopic excesses have been produced by the decay of the short-lived radionuclide Fe-60 (T(sub 1/2) = 1.5 Ma). Because CK originates from a planetesimal which was totally molten and its high Fe/Ni ratio is due to a planet-wide Fe-Ni fractionation during metal-silicate segregation, the presence of the Fe-60 decay product indicates the large scale abundance of Fe-60 in the early solar system and its presence during differentiation of this planetesimal. The observed variable Ni-60 excesses in different bulk samples and mineral separates from CK can only be understood if some Fe-60 was still alive at the time when basaltic magma had solidified on the eucrite parent body. The lack of a correlation between Ni-60 and the respective Fe/Ni ratios in different mineral fractions from CK indicates a metamorphic remobilization of Ni after essentially all Fe-60 has decayed. However, Ni-60 from three bulk samples from different locations within the meteorite appears to correlate reasonably well with the respective Fe/Ni ratios. If we regard this correlation as an isochron then its slope yields a Fe-60/Fe-56 ratio f (3.9 +/- 0.6) x 10(exp -9) and an initial Ni-60 of 3.2 plus or minus 0.9 epsilon units at the time of crystallization of CK. Estimates based on these values and a approximately 10 Ma time interval between CK solidification and formation of the earliest condensates in the solar system followed by rapid accretion of planetary bodies indicate that the decay of Fe-60 could produce sufficient heat to melt these planetesimals. If Al-26 was present on a planetary scale as Fe-60 and at abundances close to values observed in Allende inclusions then melting of small early formed planets is inevitable. As an

  18. Phase B - final definition and preliminary design study for the initial Atmospheric Cloud Physics Laboratory (ACPL): A spacelab mission payload. Work breakdown structure for phase C/D DR-MA-06 (preliminary issue)

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The Work Breakdown Structure (WBS) and Dictionary (DR-MA-06) for initial and subsequent flights of the Atmospheric Cloud Physics Laboratory (ACPL) is presented. An attempt is made to identify specific equipment and components in each of the eleven subsystems; they are listed under the appropriate subdivisions of the WBS. The reader is cautioned that some of these components are likely to change substantially during the course of the study, and the list provided should only be considered representative.

  19. [Herbological studies on Chinese crude drug Ma-huang. Part 1-On the botanical origin of Ma-huang in ancient China and the origin of Japanese Ma-huang].

    PubMed

    Yoshizawa, Chieko; Kitade, Makiko; Mikage, Masayuki

    2005-01-01

    The botanical origin of a Chinese crude drug Ma-huang in ancient China and the origin of Japanese Ma-huang were herbologically studied. The results showed that the plants of Ephedra sinica Stapf, E. intermedia Schrenk & C. A. Meyer and E. equisetina Bunge were used as Ma-huang in China, and the first species was considered to be of high quality. The characters of Mao-zhou Ma-huang and Tong-zhou Ma-huang printed in Tu-jing-ben-cao, published in the Song Dynasty in China, were identified as E. likiangensis Florin and E. intermedia, respectively, and both species were recognized as excellent Ma-huang in the Ming Dynasty. The word origin of Katsune-kusa, the Japanese name for Ma-huang in the Heian Era, was etymologically considered as meaning the plant having reddish brown roots. In Japan, the plant of Equisetum ramosissimum Desf. var.japonicum Milde, of the family Equisetaceae, was substituted for Ma-huang in the middle of Edo Era, and it was designated that this action was based on the confusion of Ephedra plants and Equisetum plants those days in China.

  20. New developments and applications of intense pulsed radiation sources at Sandia National Laboratories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cook, D.

    In the past thirty-six months, tremendous strides have been made in x-ray production using high-current z-pinches. Today, the x-ray energy (1.9 MJ) and power (200 TW) output of the Z accelerator (formerly PBFA-II) is the largest available in the laboratory. These z-pinch x-ray sources are being developed for research into the physics of high energy density plasmas of interest in weapon behavior and in inertial confinement fusion. Beyond the Z accelerator current of 20 MA, an extrapolation to the X-1 accelerator level of 60 MA may have the potential to drive high-yield ICF reactions at affordable cost if several challengingmore » technical problems can be overcome. New developments have also taken place at Sandia in the area of high current, mm-diameter electron beams for advanced hydrodynamic radiography. On SABRE, x-ray spot diameters were less than 2 mm with a dose of 100 R at 1 meter in a 40 ns pulse.« less

  1. Construction and Initial Tests of MAIZE: 1 MA LTD-Driven Z-Pinch *

    NASA Astrophysics Data System (ADS)

    Gilgenbach, R. M.; Gomez, M. R.; Zier, J. C.; Tang, W.; French, D. M.; Lau, Y. Y.; Mazarakis, M. G.; Cuneo, M. E.; Johnston, M. D.; Oliver, B. V.; Mehlhorn, T. A.; Kim, A. A.; Sinebryukhov, V. A.

    2008-11-01

    We report construction and initial testing of a 1-MA Linear Transformer Driver (LTD), The Michigan Accelerator for Inductive Z-pinch Experiments, (MAIZE). This machine, the first of its type to reach the USA, is based on the joint HCEI, Sandia Laboratories, and UM development effort. The compact LTD uses 80 capacitors and 40 spark gap switches, in 40 ``bricks'', to deliver 1 MA, 100 kV pulses with 70 ns risetime into a matched resistive load. Test results will be presented for a single brick and the full LTD. Design and construction will be presented of a low-inductance MITL. Experimental research programs under design and construction at UM include: a) Studies of Magneto-Raleigh-Taylor Instability of planar foils, and b) Vacuum convolute studies including cathode and anode plasma. Theory and simulation results will be presented for these planned experiments. Initial experimental designs and moderate-current feasibility experiments will be discussed. *Research supported by U. S. DoE through Sandia National Laboratories award document numbers 240985, 768225, 790791 and 805234 to the UM. MRG supported by NNSA Fellowship and JCZ supported by NPSC Fellowship / Sandia National Labs.

  2. Component geochronology in the polyphase ca. 3920 Ma Acasta Gneiss

    USGS Publications Warehouse

    Mojzsis, Stephen J.; Cates, Nicole L.; Caro, Guillaume; Trail, Dustin; Abramov, Oleg; Guitreau, Martin; Blichert-Toft, Janne; Hopkins, Michelle D.; Bleeker, Wouter

    2014-01-01

    The oldest compiled U–Pb zircon ages for the Acasta Gneiss Complex in the Northwest Territories of Canada span about 4050–3850 Ma; yet older ca. 4200 Ma xenocrystic U–Pb zircon ages have also been reported for this terrane. The AGC expresses at least 25 km2 of outcrop exposure, but only a small subset of this has been documented in the detail required to investigate a complex history and resolve disputes over emplacement ages. To better understand this history, we combined new ion microprobe235,238U–207,206Pb zircon geochronology with whole-rock and zircon rare earth element compositions ([REE]zirc), Ti-in-zircon thermometry (Tixln) and 147Sm–143Nd geochronology for an individual subdivided ∼60 cm2 slab of Acasta banded gneiss comprising five separate lithologic components. Results were compared to other variably deformed granitoid-gneisses and plagioclase-hornblende rocks from elsewhere in the AGC. We show that different gneissic components carry distinct [Th/U]zirc vs. Tixln and [REE]zirc signatures correlative with different zircon U–Pb age populations and WR compositions, but not with 147Sm–143Nd isotope systematics. Modeled  [REE] from lattice-strain theory reconciles only the ca. 3920 Ma zircons with the oldest component that also preserves strong positive Eu∗ anomalies. Magmas which gave rise to the somewhat older (inherited) ca. 4020 Ma AGC zircon age population formed at ∼IW (iron–wüstite) to Ma emplacement age for the AGC is contemporaneous with bombardment of the inner solar system. Analytical bombardment simulations show that crustal re-working from the impact epoch potentially affected the precursors to the Acasta gneisses.

  3. 60Ma of legume nodulation. What's new? What's changing?

    PubMed

    Sprent, Janet I

    2008-01-01

    Current evidence suggests that legumes evolved about 60 million years ago. Genetic material for nodulation was recruited from existing DNA, often following gene duplication. The initial process of infection probably did not involve either root hairs or infection threads. From this initial event, two branched pathways of nodule developmental processes evolved, one involving and one not involving the development of infection threads to 'escort' bacteria to young nodule cells. Extant legumes have a wide range of nodule structures and at least 25% of them do not have infection threads. The latter have uniform infected tissue whereas those that have infection threads have infected cells interspersed with uninfected (interstitial) cells. Each type of nodule may develop indeterminately, with an apical meristem, or show determinate growth. These nodule structures are host determined and are largely congruent with taxonomic position. In addition to variation on the plant side, the last 10 years have seen the recognition of many new types of 'rhizobia', bacteria that can induce nodulation and fix nitrogen. It is not yet possible to fit these into the emerging pattern of nodule evolution.

  4. [MaRS Project

    NASA Technical Reports Server (NTRS)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  5. The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source

    DOE PAGES

    Coates, Leighton; Cuneo, Matthew J.; Frost, Matthew J.; ...

    2015-07-18

    The Macromolecular Neutron Diffractometer (MaNDi) is located on beamline 11B of the Spallation Neutron Source at Oak Ridge National Laboratory. Moreover, the instrument is a neutron time-of-flight wavelength-resolved Laue diffractometer optimized to collect diffraction data from single crystals. Finally, the instrument has been designed to provide flexibility in several instrumental parameters, such as beam divergence and wavelength bandwidth, to allow data collection from a range of macromolecular systems.

  6. 40Ar/39Ar dating of the Mumbai tholeiites and Panvel flexure: intense 62.5 Ma onshore-offshore Deccan magmatism during India-Laxmi Ridge-Seychelles breakup

    NASA Astrophysics Data System (ADS)

    Pande, Kanchan; Yatheesh, Vadakkeyakath; Sheth, Hetu

    2017-08-01

    Mumbai, located on the western Indian continental margin, exposes Danian-age Deccan magmatic units of diverse compositions, dipping seaward due to the Panvel flexure. The Ghatkopar-Powai tholeiitic sequence contains seaward-dipping (thus pre-flexure) flows and subvertical (thus post-flexure) dykes. We present new 40Ar/39Ar ages of 62.4 ± 0.7 and 62.4 ± 0.3 Ma (2σ) on two flows, and 62.2 ± 0.3, 62.8 ± 0.3 and 61.8 ± 0.2 Ma on three dykes, showing that this sequence is much younger than the main 66-65 Ma Deccan sequence in the Western Ghats escarpment. The mutually indistinguishable ages of the Ghatkopar-Powai tholeiites overlap with available 40Ar/39Ar ages of 62.6 ± 0.6 and 62.9 ± 0.2 Ma for the seaward-dipping Dongri rhyolite flow and 62.2 ± 0.6 Ma for the Saki Naka trachyte intrusion, both from the uppermost Mumbai stratigraphy. The weighted mean of these eight 40Ar/39Ar ages is 62.4 ± 0.1 Ma (2 SEM), relative to an MMhb-1 monitor age of 523.1 ± 2.6 Ma (2σ), and indicates essentially contemporaneous volcanism, intrusion and tectonic flexure. This age also coincides with the rift-to-drift transition of the Seychelles and Laxmi Ridge-India breakup and the emplacement of the Raman-Panikkar-Wadia seamount chain in the axial part of the Laxmi Basin. Pre-rift magmatism is seen in the 64.55 Ma Jogeshwari basalt in Mumbai and 63.5-63.0 Ma intrusions in the Seychelles. Post-rift magmatism is seen in the 60.8-60.9 Ma Manori trachyte and Gilbert Hill basalt intrusions in Mumbai and 60-61 Ma syenitic intrusions in the Seychelles. The Mumbai area thus preserves the pre-, syn- and post-rift onshore tectonomagmatic record of the breakup between the Seychelles and the Laxmi Ridge-India. Voluminous submarine volcanism forming the Raman, Panikkar and Wadia seamounts in the Laxmi Basin represents the offshore syn-rift magmatism.

  7. Stormwater Pollution Prevention Plan for the TA-60-01 Heavy Equipment Shop, Los Alamos National Laboratory, Revision 3, January 2018

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burgin, Jillian Elizabeth

    This Storm Water Pollution Prevention Plan (SWPPP) was developed in accordance with the provisions of the Clean Water Act (33 U.S.C. §§1251 et seq., as amended), and the Multi-Sector General Permit for Storm Water Discharges Associated with Industrial Activity (U.S. EPA, June 2015) issued by the U.S. Environmental Protection Agency (EPA) for the National Pollutant Discharge Elimination System (NPDES) and using the industry specific permit requirements for Sector P-Land Transportation and Warehousing as a guide. This SWPPP applies to discharges of stormwater from the operational areas of the TA-60-01 Heavy Equipment Shop at Los Alamos National Laboratory. Los Alamos Nationalmore » Laboratory (also referred to as LANL or the “Laboratory”) is owned by the Department of Energy (DOE), and is operated by Los Alamos National Security, LLC (LANS). Throughout this document, the term “facility” refers to the TA-60-01 Heavy Equipment Shop and associated areas. The current permit expires at midnight on June 4, 2020.« less

  8. Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes

    PubMed Central

    Murphy, Sinead M; Khan, Usman; Alifrangis, Constantine; Hazell, Steven; Hrouda, David; Blake, Julian; Ball, Joanna; Gabriel, Carolyn; Markarian, Pierre; Rees, Jeremy; Karim, Abid; Seckl, Michael J; Lunn, Michael P; Reilly, Mary M

    2013-01-01

    Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours.1, 2 Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis.2, 3 We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis. PMID:21205983

  9. COOPER - PRELAUNCH (MA-9)

    NASA Image and Video Library

    1963-04-23

    S63-07521 (15 May 1963) --- Astronaut L. Gordon Cooper Jr., pilot of the Mercury-Atlas 9 (MA-9) Earth-orbital space mission, is assisted into his "Faith 7" Mercury spacecraft during the prelaunch countdown. MA-9 was launched on May 15, 1963, and the flight lasted for 34 hours and 20 minutes. Photo credit: NASA

  10. A Laboratory Study of X-to-Frequency Converters.

    ERIC Educational Resources Information Center

    Kartalopoulos, Stamatios V.

    1979-01-01

    Describes a laboratory demonstration that can be used to convert an analog quantity into frequency, which can then be converted into a binary measure using either an oscilloscope or a frequency counter. (MA)

  11. In vivo longitudinal chromatic aberration of pseudophakic eyes.

    PubMed

    Siedlecki, Damian; Jóźwik, Agnieszka; Zając, Marek; Hill-Bator, Aneta; Turno-Kręcicka, Anna

    2014-02-01

    To present the results of longitudinal chromatic aberration measurements on two groups of pseudophakic eyes in comparison to healthy eyes. The longitudinal chromatic aberration of the eye, defined as chromatic difference of refraction with disabled accommodation, was measured with the use of a visual refractometer with a custom-designed target illuminator consisting of a narrow-band RGB diode (blue λb = 470 ± 15 nm; green λg = 525 ± 18 nm; red λr = 660 ± 10 nm). The measurements were performed on nine eyes implanted with AcrySof IQ SN60WF, 14 eyes implanted with AcrySof SA60AT, and 10 phakic eyes under cycloplegia. The mean values of the longitudinal chromatic aberration between 470 and 660 nm for the control group was 1.12 ± 0.14 D. For SA60AT group, it was 1.45 ± 0.42 D whereas for SN60WF it was 1.17 ± 0.52 D. The statistical test showed significant difference between SA60AT and the control group (p < 0.05) and no significant difference between SN60WF and the control groups (p = 0.64). The study showed that the longitudinal chromatic aberration in vivo can be easily and reliably estimated with an adapted visual refractometer. The two groups of pseudophakic eyes measured in this study showed different values of chromatic aberration. Its magnitude for SA60AT group was significantly larger than for the control group whereas for SN60WF the difference was not significant. The optical material used for intraocular lens design may have significant influence on the magnitude of the chromatic aberration of the pseudophakic eye, and therefore on its optical and visual performance in polychromatic light.

  12. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis.

    PubMed

    Chung, Tae Ho; Kang, Tae Jin; Cho, Won-Kyung; Im, Ga Young; Lee, Geum Seon; Yang, Min Cheol; Cho, Chang-Won; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule.

  13. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

    PubMed Central

    Chung, Tae Ho; Kang, Tae Jin; Cho, Won-Kyung; Im, Ga Young; Lee, Geum Seon; Yang, Min Cheol; Cho, Chang-Won; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule. PMID:22454683

  14. MA transmutation performance in the optimized MYRRHA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Malambu, E.; Van den Eynde, G.; Fernandez, R.

    MYRRHA (multi-purpose hybrid research reactor for high-tech applications) is a multipurpose research facility currently being developed at SCK-CEN. It will be able to work in both critical and subcritical modes and, cooled by lead-bismuth eutectic. In this paper the minor actinides (MA) transmutation capabilities of MYRRHA are investigated. (Pu + Am, U) MOX fuel and (Np + Am + Cm, Pu) Inert Matrix Fuel test samples have been loaded in the central channel of the MYRRHA critical core and have been irradiated during five cycles, each one consisting of 90 days of operation at 100 MWth and 30 days ofmore » shutdown. The reactivity worth of the test fuel assembly was about 1.1 dollar. A wide range of burn-up level has been achieved, extending from 42 to 110 MWd/kg HM, the samples with lower MA-to-Pu ratios reaching the highest burn-up. This study has highlighted the importance of the initial MA content, expressed in terms of MA/Pu ratio, on the transmutation rate of MA elements. For (Pu + Am, U) MOX fuel samples, a net build-up of MA is observed when the initial content of MA is very low (here, 1.77 wt% MA/Pu) while a net decrease in MA is observed in the sample with an initial content of 5 wt%. This suggests the existence of some 'equilibrium' initial MA content value beyond which a net transmutation is achievable.« less

  15. Effects of previous episodes of influenza and vaccination in preventing laboratory-confirmed influenza in Navarre, Spain, 2013/14 season.

    PubMed

    Castilla, Jesús; Navascués, Ana; Fernández-Alonso, Mirian; Reina, Gabriel; Albéniz, Esther; Pozo, Francisco; Álvarez, Nerea; Martínez-Baz, Iván; Guevara, Marcela; García-Cenoz, Manuel; Irisarri, Fátima; Casado, Itziar; Ezpeleta, Carmen

    2016-06-02

    We estimated whether previous episodes of influenza and trivalent influenza vaccination prevented laboratory-confirmed influenza in Navarre, Spain, in season 2013/14. Patients with medically-attended influenza-like illness (MA-ILI) in hospitals (n = 645) and primary healthcare (n = 525) were included. We compared 589 influenza cases and 581 negative controls. MA-ILI related to a specific virus subtype in the previous five seasons was defined as a laboratory-confirmed influenza infection with the same virus subtype or MA-ILI during weeks when more than 25% of swabs were positive for this subtype. Persons with previous MA-ILI had 30% (95% confidence interval (CI): -7 to 54) lower risk of MA-ILI, and those with previous MA-ILI related to A(H1N1)pdm09 or A(H3N2) virus, had a, respectively, 63% (95% CI: 16-84) and 65% (95% CI: 13-86) lower risk of new laboratory-confirmed influenza by the same subtype. Overall adjusted vaccine effectiveness in preventing laboratory-confirmed influenza was 31% (95% CI: 5-50): 45% (95% CI: 12-65) for A(H1N1)pdm09 and 20% (95% CI: -16 to 44) for A(H3N2). While a previous influenza episode induced high protection only against the same virus subtype, influenza vaccination provided low to moderate protection against all circulating subtypes. Influenza vaccine remains the main preventive option for high-risk populations.

  16. Gunbarrel mafic magmatic event: A key 780 Ma time marker for Rodinia plate reconstructions

    USGS Publications Warehouse

    Harlan, S.S.; Heaman, L.; LeCheminant, A.N.; Premo, W.R.

    2003-01-01

    Precise U-Pb baddeleyite dating of mafic igneous rocks provides evidence for a widespread and synchronous magmatic event that extended for >2400 km along the western margin of the Neoproterozoic Laurentian craton. U-Pb baddeleyite analyses for eight intrusions from seven localities ranging from the northern Canadian Shield to northwestern Wyoming-southwestern Montana are statistically indistinguishable and yield a composite U-Pb concordia age for this event of 780.3 ?? 1.4 Ma (95% confidence level). This 780 Ma event is herein termed the Gunbarrel magmatic event. The mafic magmatism of the Gunbarrel event represents the largest mafic dike swarm yet identified along the Neoproterozoic margin of Laurentia. The origin of the mafic magmatism is not clear, but may be related to mantle-plume activity or upwelling asthenosphere leading to crustal extension accompanying initial breakup of the supercontinent Rodinia and development of the proto-Pacific Ocean. The mafic magmatism of the Gunbarrel magmatic event at 780 Ma predates the voluminous magmatism of the 723 Ma Franklin igneous event of the northwestern Canadian Shield by ???60 m.y. The precise dating of the extensive Neoproterozoic Gunbarrel and Franklin magmatic events provides unique time markers that can ultimately be used for robust testing of Neoproterozoic continental reconstructions.

  17. 24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass, Climatic Building, First Floor Plan, Architectural. Drawing No. 35-07-01, Sheet 2 of 72, 1952, updated to 1985. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

  18. 25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass. Climatic Building, First Floor Plan, Refrigeration and Engineering. Drawing No. 35-07-01, Sheet 52 of 72, 1952. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

  19. Beta-Testing Agreement | Frederick National Laboratory for Cancer Research

    Cancer.gov

    Beta-Testing Agreements are appropriate forlimited term evaluation and applications development of new software, technology, or equipment platforms by the Frederick National Laboratory in collaboration with an external commercial partner. It ma

  20. Toric Intraocular Lens for Astigmatism Correction in Cataract Patients.

    PubMed

    Razmjoo, Hassan; Ghoreishi, Mohammad; Milasi, Azadeh Mohammadi; Peyman, Alireza; Jafarzadeh, Zahra; Mohammadinia, Mohadeseh; Kobra, Nasrollahi

    2017-01-01

    To assess the clinical consequences of AcrySof toric intraocular lens (IOL) and Hoya toric IOL implantation to correct preexisting corneal astigmatism in patients undergoing cataract surgery. In this study, we examined 55 eyes of 45 patients with at least 1.00 D corneal astigmatism who were scheduled for cataract surgery. After phacoemulsification, toric IOL was inserted and axis was aligned. We observed the patients, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), keratometry, manifest refraction, and IOL axis alignment 6 months after surgery. After 6 months, the UDVA was 0.17 ± 0.17 logMAR in the AcrySof group and 0.17 ± 0.18 logMar in the Hoya group. More than 78% of eyes in the AcrySof group and 80% of eyes in the Hoya toric IOL achieved a UDVA of 20/40 or better. In the AcrySof group, the mean preoperative corneal astigmatism was 2.73 ± 0.92 D. The mean postoperative refractive astigmatism was 0.84 ± 0.63 D. In the Hoya group, the preoperative corneal astigmatism was 2.58 ± 0.76 D and the postoperative refractive astigmatism was 0.87 ± 0.66 D ( P < 0.05). The mean AcrySof IOL axis rotation was 1.88° ± 3.05°. In the Hoya group, the mean axis rotation was 1.53° ± 3.66°. All changes in visual and refractive data before and after surgery were statistically significant ( P < 0.05). There was no significant difference between the two groups regarding refractive and visual outcome after surgery ( P > 0.05 for all). Implantation of AcrySof toric IOL and Hoya toric IOL was an effective way to correct preexisting corneal astigmatism in cataract surgery.

  1. USAARL NUH-60FS Acoustic Characterization

    DTIC Science & Technology

    2016-11-01

    Performance Division (APPD) previously acoustically characterized the Black Hawk flight simulator (NUH-60FS). Since that characterization, the NUH-60FS...greater than one for higher-level speakers. Black Hawk flight simulator, noise level, third octave band level UNCLAS UNCLAS UNCLAS SAR 52 Loraine St. Onge...Research Laboratory NUH-60FS Black Hawk Flight Simulator

  2. Effects of blue light-filtering intraocular lenses on the macula, contrast sensitivity, and color vision after a long-term follow-up.

    PubMed

    Kara-Junior, Newton; Espindola, Rodrigo F; Gomes, Beatriz A F; Ventura, Bruna; Smadja, David; Santhiago, Marcony R

    2011-12-01

    To evaluate the possible side effects and potential protection 5 years after implantation of an intraocular lens (IOL) with a blue-light filter (yellow tinted). Ophthalmology Department, University of São Paulo, São Paulo, Brazil. Prospective randomized clinical study. Patients with bilateral visually significant cataract randomly received an ultraviolet (UV) and blue light-filtering IOL (Acrysof Natural SN60AT) in 1 eye and an acrylic UV light-filtering only IOL (Acrysof SA60AT) in the fellow eye. The primary outcome measures were contrast sensitivity, color vision, and macular findings 5 years after surgery. The study enrolled 60 eyes of 30 patients. There were no significant clinical or optical coherence tomography findings in terms of age-related macular degeneration in any eye. There were no statistically significant differences in central macular thickness between the 2 IOL groups (P=.712). There were also no significant between-group differences under photopic or scotopic conditions at any spatial frequency studied. No statistically significant differences in the color discrimination test were found between the 2 IOL groups (P=.674). After 5 years, there were no significant differences in color perception, scotopic contrast sensitivity, or photopic contrast sensitivity between the blue light-filtering (yellow-tinted) IOL and the IOL with a UV-light filter only (untinted). The potential advantage of the tinted IOL in providing protection to macular cells remains unclear. Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  3. Initial 60Fe Abundance in the Solar Nebula Constrained by Delayed Onset of a Planetesimal Dynamo

    NASA Astrophysics Data System (ADS)

    Wang, H.; Weiss, B. P.; Crowley, J.

    2017-12-01

    The paleomagnetism of meteorites provides evidence for advecting metallic core dynamos and large-scale differentiation on their parent planetesimals. Their small sizes relative to planets enable new opportunities to understand the physics of dynamo generation. Wang et al. [2017] studied the paleomagnetism of three volcanic angrites (D'Orbigny, 4563.37±0.12 Ma; Sahara 99555, 4563.54±0.14 Ma; Asuka 881371, 4562.4±1.6 Ma) and one plutonic angrite (Angra dos Reis, 4556.51±0.11 Ma). Their results show that the older volcanic angrites recorded no detectable paleomagnetic field, while the younger plutonic angrite recorded a paleomagnetic field of 17 µT interpreted as evidence of a core dynamo on the angrite parent body (APB). This indicates that the initiation of the APB dynamo was delayed until sometime between 4 and 11 My after the formation of calcium aluminum-rich inclusions (CAIs) at 4567.30 ± 0.16 Ma. This late timing is consistent with recent planetesimal thermal evolution models invoking shallow magma oceans [Neumann et al. 2014], which predict that planetesimal dynamos would not initiate until the core began to crystallize. It is also consistent with thermal evolution models invoking large-scale magma oceans that considered thermal blanketing of the core by 26Al decay in the mantle [Roberts et al. 2013, Sterenborg and Crowley 2013], which would delay thermal convection dynamos until several My after accretion (occurred <0.25 My after CAIs for the APB [Schiller et al. 2015]) and differentiation. Because the presence of even a small amount of 60Fe in the core could effectively remove the thermal blanketing effect of mantle 26Al, we can use the delay in timing of the dynamo to constrain the abundance of 60Fe on the APB. Our planetesimal thermal evolution models show that if the initial solar nebula 60Fe/56Fe ratio was greater than 5×10-9, the APB core dynamo would have to start earlier than 4 My after CAIs, in contradiction to the paleomagnetic constraints

  4. Identification and characterization of novel NuMA isoforms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, Jin, E-mail: petersdu2112@hotmail.com; Xu, Zhe; Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing

    2014-11-21

    Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMAmore » isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.« less

  5. MaRIE X-Ray Free-Electron Laser Pre-Conceptual Design

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carlsten, Bruce E.; Barnes, Cris W.; Bishofberger, Kip A.

    2011-01-01

    The proposed Matter-Radiation Interactions in Extremes (MaRIE) facility at the Los Alamos National Laboratory will include a 50-keV X-Ray Free-Electron Laser (XFEL), a significant extension from planned and existing XFEL facilities. To prevent an unacceptably large energy spread arsing from energy diffusion, the electron beam energy should not exceed 20 GeV, which puts a significant constraint on the beam emittance. A 100-pC baseline design is presented along with advanced technology options to increase the photon flux and to decrease the spectral bandwidth through pre-bunching the electron beam.

  6. The banana fruit Dof transcription factor MaDof23 acts as a repressor and interacts with MaERF9 in regulating ripening-related genes

    PubMed Central

    Feng, Bi-hong; Han, Yan-chao; Xiao, Yun-yi; Kuang, Jian-fei; Fan, Zhong-qi; Chen, Jian-ye; Lu, Wang-jin

    2016-01-01

    The DNA binding with one finger (Dof) proteins, a family of plant-specific transcription factors, are involved in a variety of plant biological processes. However, little information is available on their involvement in fruit ripening. We have characterized 25 MaDof genes from banana fruit (Musa acuminata), designated as MaDof1–MaDof25. Gene expression analysis in fruit subjected to different ripening conditions revealed that MaDofs were differentially expressed during different stages of ripening. MaDof10, 23, 24, and 25 were ethylene-inducible and nuclear-localized, and their transcript levels increased during fruit ripening. Moreover, yeast two-hybrid and bimolecular fluorescence complementation analyses demonstrated a physical interaction between MaDof23 and MaERF9, a potential regulator of fruit ripening reported in a previous study. We determined that MaDof23 is a transcriptional repressor, whereas MaERF9 is a transcriptional activator. We suggest that they might act antagonistically in regulating 10 ripening-related genes, including MaEXP1/2/3/5, MaXET7, MaPG1, MaPME3, MaPL2, MaCAT, and MaPDC, which are associated with cell wall degradation and aroma formation. Taken together, our findings provide new insight into the transcriptional regulation network controlling banana fruit ripening. PMID:26889012

  7. 9 CFR 439.60 - Notification and hearings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ACCREDITATION OF NON-FEDERAL CHEMISTRY LABORATORIES § 439.60 Notification and hearings. Accreditation of any laboratory will be refused, suspended, or revoked under the conditions previously described in this Part 439. The owner or operator of the laboratory will be sent written notice of the refusal, suspension, or...

  8. Kinetics of Cyclic Oxidation and Cracking and Finite Element Analysis of MA956 and Sapphire/MA956 Composite System

    NASA Technical Reports Server (NTRS)

    Lee, Kang N.; Arya, Vinod K.; Halford, Gary R.; Barrett, Charles A.

    1996-01-01

    Sapphire fiber-reinforced MA956 composites hold promise for significant weight savings and increased high-temperature structural capability, as compared to unreinforced MA956. As part of an overall assessment of the high-temperature characteristics of this material system, cyclic oxidation behavior was studied at 1093 C and 1204 C. Initially, both sets of coupons exhibited parabolic oxidation kinetics. Later, monolithic MA956 exhibited spallation and a linear weight loss, whereas the composite showed a linear weight gain without spallation. Weight loss of the monolithic MA956 resulted from the linking of a multiplicity of randomly oriented and closely spaced surface cracks that facilitated ready spallation. By contrast, cracking of the composite's oxide layer was nonintersecting and aligned nominally parallel with the orientation of the subsurface reinforcing fibers. Oxidative lifetime of monolithic MA956 was projected from the observed oxidation kinetics. Linear elastic, finite element continuum, and micromechanics analyses were performed on coupons of the monolithic and composite materials. Results of the analyses qualitatively agreed well with the observed oxide cracking and spallation behavior of both the MA956 and the Sapphire/MA956 composite coupons.

  9. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  10. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  11. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  12. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a contribution into an...

  13. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  14. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  15. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  16. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Prompt payment by MA organization. 422.520 Section... Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide that the MA...

  17. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Prompt payment by MA organization. 422.520 Section... Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide that the MA...

  18. Reconstruction of Northeast Asian Deformation Integrated with Western Pacific Plate Subduction since 200 Ma

    NASA Astrophysics Data System (ADS)

    Liu, S.; Gurnis, M.; Ma, P.; Zhang, B.

    2017-12-01

    The configuration and kinematics of continental deformation and its marginal plate tectonics on the Earth's surface are intrinsic manifestations of plate-mantle coupling. The complex interactions of plate boundary forces result in plate motions that are dominated by slab pull and ridge push forces and the effects of mantle drag; these interactions also result in continental deformation with a complex basin-mountain architecture and evolution. The kinematics and evolution of the western Pacific subduction and northeast Asian continental-margin deformation are a first-order tectonic process whose nature and chronology remains controversial. This paper implements a "deep-time" reconstruction of the western Pacific subduction, continental accretion or collision and basin-mountain deformation in northeast Asia since 200 Ma based on a newly revised global plate model. The results demonstrate a NW-SE-oriented shortening from 200-137 Ma, a NWW-SEE-oriented extension from 136-101 Ma, a nearly N-S-oriented extension and uplift with a short-term NWW-SEE-oriented compressional inversion in northeast China from 100-67 Ma, and a NW-SE- and nearly N-S-oriented extension from 66 Ma to the present day. The western Pacific oceanic plate subducted forward under East Asia along Mudanjiang-Honshu Island during the Jurassic, and the trenches retreated to the Sikhote-Alin, North Shimanto, and South Shimanto zones from ca. 137-128 Ma, ca. 130-90 Ma, and in ca. 60 Ma, respectively. Our time-dependent analysis of plate motion and continental deformation coupling suggests that the multi-plate convergent motion and ocean-continent convergent orogeny were induced by advance subduction during the Jurassic and earliest Cretaceous. Our analysis also indicates that the intra-continent rifting and back-arc extension were triggered by trench retreat during the Cretaceous and that the subduction of oceanic ridge and arc were triggered by trench retreat during the Cenozoic. Therefore, reconstructing

  19. An Overview of the MaRIE X-FEL and Electron Radiography LINAC RF Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bradley, Joseph Thomas III; Rees, Daniel Earl; Scheinker, Alexander

    The purpose of the Matter-Radiation Interactions in Extremes (MaRIE) facility at Los Alamos National Laboratory is to investigate the performance limits of materials in extreme environments. The MaRIE facility will utilize a 12 GeV linac to drive an X-ray Free-Electron Laser (FEL). Most of the same linac will also be used to perform electron radiography. The main linac is driven by two shorter linacs; one short linac optimized for X-FEL pulses and one for electron radiography. The RF systems have historically been the one of the largest single component costs of a linac. We will describe the details of themore » different types of RF systems required by each part of the linacs. Starting with the High Power RF system, we will present our methodology for the choice of RF system peak power and pulselength with respect to klystron parameters, modulator parameters, performance requirements and relative costs. We will also present an overview of the Low Level RF systems that are proposed for MaRIE and briefly describe their use with some proposed control schemes.« less

  20. European Fiber Optics. USAF Laboratory Experts’ Visit,

    DTIC Science & Technology

    1979-12-01

    emitting at 480 ma. AE-Telefunken Telecomunications and Cable Systems Division Postfach 1120 7150 Backnang, Germany Principal Contact: Dr. K. D. 4chenkel...alignment purposes. Standard Telecomunication Laboratories, Inc. (STL) London Road Harlow, Essex 017 9NA, England Principal Contact: Dr. M. Chown - Manager

  1. Transfer of Methamphetamine (MA) into Breast Milk and Urine of Postpartum Women who Smoked MA Tablets during Pregnancy: Implications for Initiation of Breastfeeding.

    PubMed

    Chomchai, Chulathida; Chomchai, Summon; Kitsommart, Ratchada

    2016-05-01

    Methamphetamine (MA) use by pregnant women remains a growing problem in South East Asia. After delivery, a negative maternal urine MA assay is assumed to reflect the absence of MA in breast milk and marks breastfeeding initiation. To date, no data exist that describe the relationship between the peripartum and postpartum transfer of MA into breast milk and its urinary excretion in women, following recreational use by smoking. This study aimed to determine the pharmacokinetic of smoked MA in breast milk and its relationship to urinary MA excretion in postpartum women who tested positive for MA before delivery. Timed urine and breast milk samples of 33 women who had positive urine drug screens for MA prior to delivery were analyzed for MA using Acquity Ultra Performance Liquid Chromatography (Waters, Milford, Massachusetts, USA) with the ACQUITY UPLC Photodiode Array Detector (Waters). Those participants with 4 or more timed breast milk samples were included for pharmacokinetic calculation using log-linear trapezoidal rule. Pharmacokinetic data from 2 women were analyzed. The half-life values for MA in the breast milk were 11.3 and 40.3 hours. The absolute infant doses were 21.3 and 51.7 µg/kg/day. Methamphetamine disappears from breast milk approximately 1 day before the maternal urine MA becomes negative. Smoked MA shows a similar breast milk pharmacokinetic pattern to previously reported intravenous MA. Breastfeeding can be safely initiated in mothers whose urine MA screen has turned negative for ≥ 24 hours. However, concurrent maternal substance use treatment and screening is necessary for continued promotion of lactation. © The Author(s) 2015.

  2. Oversight of High-Containment Biological Laboratories: Issues for Congress

    DTIC Science & Technology

    2009-03-27

    construction of two BSL-4 National Biocontainment Laboratories ( NBLs ) and thirteen BSL-3 Regional Biocontainment Laboratories (RBLs). The NBLs and...Congressional Research Service 13 to assist public health efforts during a bioterrorism emergency.50 The two NBLs are being built in Boston, MA, and Galveston...TX.51 The RBLs are geographically dispersed throughout the United States.52 The NBLs and RBLs are being constructed through a grant-making process

  3. Oversight of High-Containment Biological Laboratories: Issues for Congress

    DTIC Science & Technology

    2009-05-04

    construction of two BSL-4 National Biocontainment Laboratories ( NBLs ) and thirteen BSL-3 Regional Biocontainment Laboratories (RBLs). The NBLs and RBLs...Research Service 13 to assist public health efforts during a bioterrorism or emerging infectious disease emergency.50 The two NBLs are being built in...Boston, MA, and Galveston, TX.51 The RBLs are geographically dispersed throughout the United States.52 The NBLs and RBLs are being constructed

  4. The case for nearly continuous extension of the West Antarctic Rift System, 105-25 Ma (Invited)

    NASA Astrophysics Data System (ADS)

    Wilson, D. S.; Luyendyk, B. P.

    2010-12-01

    It is a common perception that extension in the West Antarctic Rift System (WARS) was a two-phase process, with a Cretaceous phase ending when the Campbell Plateau rifted from West Antarctica (~80 Ma), and a mid-Cenozoic phase synchronous with sea floor spreading in the Adare trough (~45-25 Ma). Several lines of evidence indicate that significant extension probably occurred in the intervening 80-45 Ma interval. The strongest evidence comes from subsidence rates on the Central High and Coulman High structures in the central-western Ross Sea, where DSDP Site 270 and other areas with shallow basement have subsided 1 km or more since Oligocene time. With sediment load, these subsidence rates are reasonable for thermal subsidence resulting from extension with a stretching factor of about 2.0-2.5 at about 50-70 Ma, but are hard to reconcile with an extension age around 90 Ma. The seismic velocity structure of the WARS inferred from global surface-wave dispersion is similar to that of oceanic lithosphere of age 40-60 Ma [Ritzwoller et al., 2001 JGR]. Geometric relations of sea floor between Adare Trough and Iselen Bank, northwest Ross Sea, suggest sea floor spreading of about 130 km during early Cenozoic, before the Adare Trough spreading episode started. Numerous cooling ages in the Transantarctic Mountains in the range of 55-45 Ma [Fitzgerald, 1992 Tectonics; Miller et al., 2010 Tectonics] support the interpretation of significant extension prior to 45 Ma. Present crustal thickness of about 22 km near DSDP Site 270 [Trey et al., 1999 Tectonophysics] suggests a pre-extension crustal thickness exceeding 50 km. A simple overall interpretation follows that the WARS has a tectonic history similar to the Basin and Range of western North America: a thick-crust orogenic highland extended for many tens of million years. The main difference between the WARS and the Basin and Range is the post-tectonic cooling and subsidence in the WARS.

  5. Stormwater Pollution Prevention Plan for the TA-60-02 Salvage Warehouse, Los Alamos National Laboratory, Revision 3, January 2018

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burgin, Jillian Elizabeth

    This Storm Water Pollution Prevention Plan (SWPPP) was developed in accordance with the provisions of the Clean Water Act (33 U.S.C. §§1251 et seq., as amended), and the Multi-Sector General Permit for Storm Water Discharges Associated with Industrial Activity (U.S. EPA, June 2015) issued by the U.S. Environmental Protection Agency (EPA) for the National Pollutant Discharge Elimination System (NPDES) and using the industry specific permit requirements for Sector P-Land Transportation and Warehousing as a guide. The applicable stormwater discharge permit is EPA General Permit Registration Number NMR053915 (Los Alamos National Security (LANS) (U.S. EPA, June 2015). Contents of the Junemore » 4, 2015 Multi-sector General Permit can be viewed at: https://www.epa.gov/sites/production/files/2015- 10/documents/msgp2015_finalpermit.pdf This SWPPP applies to discharges of stormwater from the operational areas of the TA-60-02 Salvage and Warehouse facility at Los Alamos National Laboratory. Los Alamos National Laboratory (also referred to as LANL or the “Laboratory”) is owned by the Department of Energy (DOE), and is operated by Los Alamos National Security, LLC (LANS). Throughout this document, the term “facility” refers to the TA-60-02 Salvage/ Warehouse and associated areas. The current permit expires at midnight on June 4, 2020. A copy of the facility NOI and LANS Delegation of Authority Letter are located in Appendix C of this SWPPP.« less

  6. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan must make...) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual deductible at...

  7. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  8. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  9. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a) An...

  10. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan must make...) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual deductible at...

  11. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  12. Introductory Oceanography Taught as a Laboratory Science--An Experiment That Worked.

    ERIC Educational Resources Information Center

    Anderson, Franz E.

    1979-01-01

    Describes a college level introductory oceanography course that incorporates a hands-on laboratory component. The activities include the determination of density and buoyancy, light transmission in sea water, and wave refraction. (MA)

  13. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  14. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  15. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  16. MIT Lincoln Laboratory Annual Report 2014

    DTIC Science & Technology

    2014-01-01

    NAME(S) AND ADDRESS(ES) Massachusetts Institute of Technology,Lincoln Laboratory,244 Wood Street,Lexington,MA,02420 8. PERFORMING ORGANIZATION...microseconds) transmon qubits. Juan Montoya, Andrew Benedick, and Scot Shaw use prototype technology to demonstrate a new optical phased array beam...really care about. In fact, the Woods Hole Oceanographic Institution, which is designing and building UUVs, is interested in the systems the

  17. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response.

    PubMed

    Fan, Zhong-Qi; Chen, Jian-Ye; Kuang, Jian-Fei; Lu, Wang-Jin; Shan, Wei

    2017-01-01

    The regulation of ICE1 protein stability is important to ensure effective cold stress response, and is extensively studied in Arabidopsis . Currently, how ICE1 stability in fruits under cold stress is controlled remains largely unknown. Here, we reported the possible involvement of a SEVEN IN ABSENTIA (SINA) ubiquitin ligase MaSINA1 from banana fruit in affecting MaICE1 stability. MaSINA1 was identified based on a yeast two-hybrid screening using MaICE1 as bait. Further yeast two-hybrid, pull-down, bimolecular fluorescence complementation (BiFC) and co-immunoprecipitation (CoIP) assays confirmed that MaSINA1 interacted with MaICE1. The expression of MaSINA1 was repressed by cold stress. Subcellular localization analysis in tobacco leaves showed that MaSINA1 was localized predominantly in the nucleus. In vitro ubiquitination assay showed that MaSINA1 possessed E3 ubiquitin ligase activity. More importantly, in vitro and semi- in vivo experiments indicated that MaSINA1 can ubiquitinate MaICE1 for the 26S proteasome-dependent degradation, and therefore suppressed the transcriptional activation of MaICE1 to MaNAC1, an important regulator of cold stress response of banana fruit. Collectively, our data reveal a mechanism in banana fruit for control of the stability of ICE1 and for the negative regulation of cold stress response by a SINA E3 ligase via the ubiquitin proteasome system.

  18. Report on Operations of the Air Force Geophysics Laboratory Infrared Array Spectrometer

    DTIC Science & Technology

    1993-01-25

    AIR FORCE GEOPHYSICS LABORATORY INFRARED ARRAY... LABORATORY Directorate of Geophysics AIR FORCE MATERIEL COMMAND HANSCOM AIR FORCE BASE, MA 01731-3010 93-27655IEEE|EIIE1ENI This technical report has...ACKNOWLEDGMENT We are grateful to the Air Force Office of Scientific Research , especially Henry Radowski. for their financial corn- mitment to this project.

  19. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  20. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  1. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  2. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  3. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  4. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  5. Preliminary experiments to estimate the PE.MA.M (PElagic MArine Mesocosm) offshore behaviour

    NASA Astrophysics Data System (ADS)

    Albani, Marta; Piermattei, Viviana; Stefanì, Chiara; Marcelli, Marco

    2016-04-01

    The phytoplankton community is controlled not only by local environmental conditions but also by physical processes occurring on different temporal and spatial scales. Hydrodynamic local conditions play an important role in marine ecosystems. Several studies have shown that hydrodynamic conditions can influence the phytoplankton settling velocity, vertical and horizontal distribution and formation of cyanobacterial blooms. Mesocosms are useful structures to simulate marine environment at mesoscale resolution; allowing to closely approximate biotic or abiotic parameters of interest directly in nature. In this work an innovative structure named PE.MA.M (PElagic MArine Mesocosm) is presented and tested. Laboratory experiments have been conducted in order to observe seasonal variations of biomass behaviour in two different hydrodynamic conditions: outside as well as whithin the PE.MA.M. We have evaluated whether it is possible to isolate a natural system from external water mass hydrodynamic exchanges and to assume that phytoplankton cells' transition is limited at the net and sea interface. Preliminary experiments test the isolating capacity of the net, to determine the currents' attenuation rate and to estimate the possible PE.MA.M. offshore behaviour. In the first investigation, we monitored the diffusion of phytoplankton cells. The PE.MA.M. exterior and interior were simulated using a plexiglass tank divided into two half-tanks (Aout-Bin) by a septum consisting of a net like a PE.MA.M. The tank was filled up with 10 L of water and only the half-tank Aout was filled up with 10 ml of phytoplankton culture (Clorella sp.). We monitored the chlorophyll concentrations for 24 hours. The two tanks had similar concentrations after 4 hours (2.70322 mg/m³ Aout and 2.37245 mg/m3 Bin) and this constant relationship was maintened until the end of the test. In the second investigation we used clod cards to measure water motions.We conducted two experiments within tank, the first

  6. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Disenrollment by the MA organization. 422.74... § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA plan it...

  7. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 422.112 are met for that individual through the MA plan's established provider network. The MA...; (4) Has been a member of an Employer Group Health Plan (EGHP) that includes the elected MA plan, even... are met for that individual through the MA plan's established provider network. The MA organization...

  8. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area for an MA...

  9. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area for an MA...

  10. Upbeat nystagmus in anti-Ma2 encephalitis.

    PubMed

    Garcia-Reitboeck, Pablo; Thompson, Graham; Johns, Paul; Al Wahab, Yasir; Omer, Salah; Griffin, Colette

    2014-02-01

    Anti-Ma2 encephalitis is a paraneoplastic disorder characterised by brainstem and/or limbic involvement. Eye movement abnormalities can occur in this condition, often with confusion or somnolence. We describe a patient with progressive oscillopsia (with upbeat nystagmus) and unsteadiness, followed by acute pancreatitis. She did not respond to immunomodulatory treatment and subsequently died of complications related to pancreatitis and sepsis. There was no tumour identified at autopsy, but the anti-Ma2 antibodies in her serum and the discovery of a brainstem-predominant inflammatory infiltrate at autopsy strongly suggest a paraneoplastic disorder. Our case illustrates that upbeat nystagmus can be a predominant feature in anti-Ma2 encephalitis; clinicians should consider testing for anti-Ma2 antibodies in patients with upbeat nystagmus of unknown cause.

  11. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

    PubMed

    Rosenfeld, M R; Eichen, J G; Wade, D F; Posner, J B; Dalmau, J

    2001-09-01

    Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. Preliminary studies suggested the existence of other Ma proteins and different patterns of immune response associated with distinct neurologic symptoms and cancers. In this study, our aim was to isolate the full-length sequence of Ma2 and new family members, identify the major autoantigen of the disorder, and extend the dinical-immunological analysis to 29 patients. Sera from selected patients were used to probe a brainstem cDNA library and isolate the entire Ma2 gene and a new family member, Ma3. Ma3 mRNA is ubiquitously expressed in brain, testis, and several systemic tissues. The variable cellular expression of Ma proteins and analysis of protein motifs suggest that these proteins play roles in the biogenesis of mRNA. Immunoblot studies identify Ma2 as the major autoantigen with unique epitopes recognized by all patients' sera. Eighteen patients had antibodies limited to Ma2: they developed limbic, hypothalamic, and brainstem encephalitis, and 78% had germ-cell tumors of the testis. Eleven patients had antibodies to Ma2 and additional antibodies to Ma1 and/or Ma3; they usually developed additional cerebellar symptoms and more intense brainstem dysfunction, and 82% of these patients had tumors other than germ-cell neoplasms. Overall, 17 of 24 patients (71%) with brain magnetic resonance imaging studies had abnormalities within or outside the temporal lobes, some as contrast-enhancing nodular lesions. A remarkable finding of immunity to Ma proteins is that neurologic symptoms may improve or resolve. This improvement segregated to a group of patients with antibodies limited to Ma2.

  12. Monte Carlo study of a 60Co calibration field of the Dosimetry Laboratory Seibersdorf.

    PubMed

    Hranitzky, C; Stadtmann, H

    2007-01-01

    The gamma radiation fields of the reference irradiation facility of the Dosimetry Laboratory Seibersdorf with collimated beam geometry are used for calibrating radiation protection dosemeters. A close-to-reality simulation model of the facility including the complex geometry of a 60Co source was set up using the Monte Carlo code MCNP. The goal of this study is to characterise the radionuclide gamma calibration field and resulting air-kerma distributions inside the measurement hall with a total of 20 m in length. For the whole range of source-detector-distances (SDD) along the central beam axis, simulated and measured relative air-kerma values are within +/-0.6%. Influences on the accuracy of the simulation results are investigated, including e.g., source mass density effects or detector volume dependencies. A constant scatter contribution from the lead ring-collimator of approximately 1% and an increasing scatter contribution from the concrete floor for distances above 7 m are identified, resulting in a total air-kerma scatter contribution below 5%, which is in accordance to the ISO 4037-1 recommendations.

  13. Ma and Japan.

    ERIC Educational Resources Information Center

    Di Mare, Lesley

    1990-01-01

    Examines the Japanese concept of "ma" (a gap or interval representing a collapse of time and space). Compares it to the Western perception of time and space. Discusses the implications it carries for the study of intercultural and intracultural communication. (SR)

  14. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Annual MA capitation rates. 422.306 Section 422.306....306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005 and each...

  15. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Annual MA capitation rates. 422.306 Section 422.306....306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005 and each...

  16. The evolution of the magmatic arc of Southern Peru (200-60 Ma), Arequipa area: insight from geochemical modeling

    NASA Astrophysics Data System (ADS)

    Demouy, S.; Benoit, M.; De Saint Blanquat, M.; Brunet, P.

    2012-12-01

    Cordilleran-type batholiths are built by prolonged arc activity along continental margins and may provide detailed magmatic records of the subduction system evolution. The magmas produced in subduction context involve both mantellic and crustal end members and are subject to various petrological processes. The MASH zones (Hildreth and Moorbath, 1988), at the basis of the continental crust, are the best places for the genesis of such hybrid magmas. The various geochemical signatures observed in the plutonic rocks, may also be attributed to source heterogeneities or generated by subsequent petrological processes. This study has focused in the Arequipa section of the Coastal Batholith of Southern Peru (200-60 Ma), in an area extending over 80x40 km. Major and trace elements as well as Sr and Nd isotopic analyses were performed in a set of 100 samples ranging from gabbro to granite. The obtained data highlight the wide heterogeneity of the geochemical signatures that is not related to the classification of the rocks. In first step, Rb/Sr systematic was used to isolate a set of samples plotting along a Paleocene isochron and defining a cogenetic suite. This suite appears to have evolved by simple fractional crystallization. By using reverse modeling, the parameters controlling the fractional crystallization process were defined, as partition coefficients, initial concentrations and amount of fractional crystallization. The other magmatic suites display a wide range of isotopic and geochemical signatures. To explain this heterogeneity, a model involving competition between fractional crystallization and magma mixing into MASH zones was proposed. A large range of hybrid magma types is potentially generated during the maturation of the system, but this range tends to disappear as fractionation and mixing occurs. Finally the model predicts the genesis of a homogeneous reservoir created at depth, from which magmas may evolve only by fractional crystallization. Therefore

  17. Untangling the mechanism of 3-methyladenine (3-MA) in enhancing the specific productivity: Transcriptome analysis of recombinant CHO cells treated with 3-MA.

    PubMed

    Baek, Eric; Lee, Jae Seong; Lee, Gyun Min

    2018-06-25

    3-Methyladenine (3-MA) is a chemical additive that enhances the specific productivity (q p ) in recombinant Chinese hamster ovary (rCHO) cell lines. Different from its widely known function of inhibiting autophagy, 3-MA has instead shown to increase autophagic flux in various rCHO cell lines. Thus, the mechanism by which 3-MA enhances the q p requires investigation. To evaluate the effect of 3-MA on transcriptome dynamics in rCHO cells, RNA-seq was performed with Fc-fusion protein-producing rCHO cells treated with 3-MA. By analyzing genes that were differentially expressed following the addition of 3-MA during culture, the role of 3-MA in the biological processes of rCHO cells was identified. One pathway markedly influenced by the addition of 3-MA was the unfolded protein response (UPR). Having a close relationship with autophagy, the UPR reestablishes protein folding homeostasis under endoplasmic reticulum (ER) stress. The addition of 3-MA increased the expression of key regulators of the UPR, such as Atf4, Ddit3, and Creb3l3, further supporting the idea that the enhancement of ER capacity acts as a key in increasing the q p . Consequently, the downstream effectors of UPR, which include autophagy-promoting genes, were upregulated as well. Hence, the role of 3-MA in increasing UPR pathway could have made a salient contribution to the increased autophagic flux in rCHO cells. Taken together, transcriptome analysis improved the understanding of the role of 3-MA in gene expression dynamics in rCHO cells and its mechanism in enhancing the q p . This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  18. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  19. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  20. INSERTION - ASTRONAUT CARPENTER - MERCURY-ATLAS (MA)-7 - CAPE

    NASA Image and Video Library

    1962-05-24

    S62-02846 (24 May 1962) --- Project Mercury astronaut M. Scott Carpenter, prime pilot for the Mercury-Atlas 7 (MA-7) mission, is assisted into the MA-7 spacecraft by techicians at Launch Pad 14, Cape Canaveral, Florida. MA-7 is the United States? second attempt in orbital flight around Earth. The spacecraft was designated the ?Aurora? 7. Photo credit: NASA

  1. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  2. Using Cellular Slime Molds in the High School Laboratory

    ERIC Educational Resources Information Center

    Haskins, P. B.

    1977-01-01

    Described is the life cycle of the cellular slime molds Acrasiales. Experiments that can be used to explore the aggregation, migration, and culmination activities of the organism are suggested. Laboratory procedures for culturing these slime molds and listings of biological supply houses and literature references are also given. (MA)

  3. MIT Lincoln Laboratory Annual Report 2012

    DTIC Science & Technology

    2012-01-01

    5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...ES) Massachusetts Institute of Technology,Lincoln Laboratory,244 Wood Street,Lexington,MA,02420-9108 8. PERFORMING ORGANIZATION REPORT NUMBER 9...spans a wide range of research areas, including high- performance detectors and focal planes, 3D integrated circuits, microelectromechanical devices

  4. New Constraints on Baja California-North America Relative Plate Motion Since 11 Ma

    NASA Astrophysics Data System (ADS)

    Bennett, S. E.; Skinner, L. A.; Darin, M. H.; Umhoefer, P. J.; Oskin, M. E.; Dorsey, R. J.

    2013-12-01

    Tectonic reconstructions of the Pacific-North America (PAC-NAM) plate boundary across the Gulf of California and Salton Trough (GCAST) constrain the controversial magnitude of Baja California microplate-North America (BCM-NAM) relative motion since middle Miocene time. We use estimates of total PAC-NAM relative dextral-oblique motion from the updated global plate-circuit model (Atwater and Stock, 2013; GSA Cordilleran Mtg) to resolve the proportion of this motion on faults east of the BCM. Modern GPS studies and offset of late Miocene cross-gulf geologic tie points both suggest that BCM has never been completely coupled to the Pacific plate. Thus, our preferred GCAST reconstruction uses 93% BCM-PAC coupling from the present back to 6 Ma. We assume BCM-PAC coupling of 60% between 6 and 7 Ma, and 25% between 7 and 11 Ma, to avoid unacceptable overlap of continental crustal blocks between Baja California and the Sierra Madre Occidental (on stable NAM). Using these coupling ratios and PAC-NAM stage Euler poles, we determine the azimuth and velocity of individual points on the BCM in 1 million year increments back to 11 Ma. This procedure accounts for minor clockwise rotation of BCM that occurred during oblique rifting, and shows how total BCM-NAM relative motion increases from north to south due to greater distance from the Euler pole. Finer-scale restoration of tectonic blocks along significant (>1 km offset) faults, across extensional (e.g. pull-apart and half-graben) basins, and by vertical-axis rotation is constrained by local geologic and marine-geophysical datasets and accomplished via the open-source Tectonic Reconstruct ArcGIS tool. We find that restoration across the Gulf of California completely closes marine basins and their terrestrial predecessors between 6 and 9 Ma. Latest Miocene opening of these basins was coincident with a ~10° clockwise azimuthal change from 8 to 6 Ma in PAC-NAM relative motion, as revealed by the global plate circuit model. The

  5. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  6. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  7. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  8. MaRIE Undulator & XFEL Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nguyen, Dinh Cong; Marksteiner, Quinn R.; Anisimov, Petr Mikhaylovich

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  9. [Ma2 antibody and multiple mononeuropathies].

    PubMed

    Ayrignac, X; Castelnovo, G; Landrault, E; Fayolle, H; Pers, Y-M; Honnorat, J; Campello, C; Figarella-Branger, D; Labauge, P

    2008-01-01

    Anti-Ma2 antibodies belong to a family of onconeuronal antibodies that target proteins expressed in brain, testis and several tumors. Previously observed in patients presenting with limbic encephalitis, they seem to be associated with several other paraneoplastic syndromes. We report the case of a 73-year-old woman presenting sensory and motor neuropathy associated with non-small-cell lung cancer who had Ma2-antibodies.

  10. Identifying the complex melting reaction from 20 Ma to 14 Ma in Tsona leucogranite in Southern Tibet: geochemistry, zircon U-Pb chronology and Hf isotopes evidence

    NASA Astrophysics Data System (ADS)

    Shi, Qingshang; Zhao, Zhidan; Liu, Dong; Zhu, Di-Cheng

    2017-04-01

    The Miocene leucogranites, the record of the evolution of the Himalayan-Tibetan Orogen, extensively intruded the Greater Himalayan Sequence (GHS), and distributed along the South Tibetan Detachment System (STDS) (Guo and Wilson, 2012). Here we present a study of geochemistry, zircon U-Pb chronology and Hf isotopes on the Yamarong leucogranites from Tsona area, Eastern Himalaya, to explore the petrogenesis of the rocks, including melting condition and mechanism, and source of fluid within the magmatism through time. Our new results include: (1) The age of the Yamarong leucogranites range from 14 Ma to 20 Ma (YM1510-1 = 19.7 ± 0.1 Ma, n = 13; YM1502-1 = 17.5 ± 0.1 Ma, n = 12; YM1412 =14.2 ± 0.1 Ma, n = 18), which suggest that the anataxis processes have lasted for more than 6 Ma. (2) The geochemical features are different between the rocks with changing ages, especially between 20 Ma and 17 Ma. The Rb/Sr value of 20 Ma leucogranites (4.1-6.84) is lower than that of 17 Ma samples (5.12-19.02). The 20 Ma leucogranites have higher Ba contents (188-337 ppm) than that of 17 Ma rocks (50-158ppm), which exhibit different trends in the Rb/Sr versus Ba plot, and reveal different melting reaction from 20 Ma to 17 Ma. (Inger and Harris, 1993) (3) The ɛHf(t) isotopes of 20 Ma leucogranites are lower (average ɛHf(t) = -12.5) than that of 17 Ma ones (average ɛHf(t) = -10), which implies differential dissolution of inherited zircon during two partial melting events possibly due to different fluid contribution (Gao et al., 2017); (4) The positive linear relationship of LREEs versus Th in the rocks, with relatively higher contents of Th and LREEs in the 20 Ma, and lower in the 17 Ma leucogranites, which suggests the relationship were mostly controlled by monazite. And this further indicates more monazite was dissolved from the source region in the early stage (˜20Ma) than the later (17Ma) (Gao et al., 2017). In summary, our study provides new evidence for the complex melting

  11. [Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].

    PubMed

    Yamamoto, Tomotaka; Tsuji, Shoji

    2010-08-01

    Anti-Ma2-associated encephalitis (or anti-Ma2 encephalitis) is a paraneoplastic neurological syndrome (PNS) characterized by isolated or combined limbic, diencephalic, or brainstem dysfunction. Anti-Ma2 antibodies detected in the serum or cerebrospinal fluid of patients are highly specific for this disease entity and belong to a group of well-characterized onconeuronal antibodies (or classical antibodies). The corresponding antigen, Ma2 is selectively expressed intracellularly in neurons and tumors as is the case with other onconeuronal antigens targeted by classical antibodies. However, in most cases the clinical pictures are different from those of classical PNS and this creates a potential risk of underdiagnosis. Although limbic dysfunction is the most common manifestation in patients with anti-Ma2 encephalitis which is one of the major causes of paraneoplastic limbic encephalitis (LE), it has been reported that less than 30% of the patients with anti-Ma2 LE exhibit clinical presentations typical of the classical description of LE. Of the remaining, many exhibit excessive daytime sleepiness, vertical ophthalmoparesis, or both associated with LE, because of frequent involvement of the diencephalon and/or upper brainstem. Anti-Ma2 LE can also be manifested as a pure psychiatric disturbance such as obsessive-compulsive disorder in a few cases. Some patients develop mesodiencephalic encephalitis with minor involvement of the limbic system, and some may manifest severe hypokinesis. About 40% of the patients with anti-Ma2 antibodies also have antibodies against different epitopes on Ma1, a homologue of Ma2. These patients may have predominant cerebellar and/or brainstem dysfunctions due to more extensive involvement of subtentorial structures. Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. While it can cause severe neurological deficits or death in a substantial

  12. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.

    PubMed

    Overeem, S; Dalmau, J; Bataller, L; Nishino, S; Mignot, E; Verschuuren, J; Lammers, G J

    2004-01-13

    Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

  13. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis

    PubMed Central

    Overeem, S.; Dalmau, J.; Bataller, L.; Nishino, S.; Mignot, E.; Verschuuren, J.; Lammers, G.J.

    2008-01-01

    Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with ideopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction. PMID:14718718

  14. Effect of astigmatism on visual acuity in eyes with a diffractive multifocal intraocular lens.

    PubMed

    Hayashi, Ken; Manabe, Shin-Ichi; Yoshida, Motoaki; Hayashi, Hideyuki

    2010-08-01

    To examine the effect of astigmatism on visual acuity at various distances in eyes with a diffractive multifocal intraocular lens (IOL). Hayashi Eye Hospital, Fukuoka, Japan. In this study, eyes had implantation of a diffractive multifocal IOL with a +3.00 diopter (D) addition (add) (AcrySof ReSTOR SN6AD1), a diffractive multifocal IOL with a +4.00 D add (AcrySof ReSTOR SN6AD3), or a monofocal IOL (AcrySof SN60WF). Astigmatism was simulated by adding cylindrical lenses of various diopters (0.00, 0.50, 1.00, 1.50, 2.00), after which distance-corrected acuity was measured at various distances. At most distances, the mean visual acuity in the multifocal IOL groups decreased in proportion to the added astigmatism. With astigmatism of 0.00 D and 0.50 D, distance-corrected near visual acuity (DCNVA) in the +4.00 D group and distance-corrected intermediate visual acuity (DCIVA) and DCNVA in the +3.00 D group were significantly better than in the monofocal group; the corrected distance visual acuity (CDVA) was similar. The DCNVA with astigmatism of 1.00 D was better in 2 multifocal groups; however, with astigmatism of 1.50 D and 2.00 D, the CDVA and DCIVA at 0.5m in the multifocal groups were significantly worse than in the monofocal group, although the DCNVA was similar. With astigmatism of 1.00 D or greater, the mean CDVA and DCNVA in the multifocal groups reached useful levels (20/40). The presence of astigmatism in eyes with a diffractive multifocal IOL compromised all distance visual acuities, suggesting the need to correct astigmatism of greater than 1.00 D. No author has a financial or proprietary interest in any material or method mentioned. Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  15. PuMA: the Porous Microstructure Analysis software

    NASA Astrophysics Data System (ADS)

    Ferguson, Joseph C.; Panerai, Francesco; Borner, Arnaud; Mansour, Nagi N.

    2018-01-01

    The Porous Microstructure Analysis (PuMA) software has been developed in order to compute effective material properties and perform material response simulations on digitized microstructures of porous media. PuMA is able to import digital three-dimensional images obtained from X-ray microtomography or to generate artificial microstructures. PuMA also provides a module for interactive 3D visualizations. Version 2.1 includes modules to compute porosity, volume fractions, and surface area. Two finite difference Laplace solvers have been implemented to compute the continuum tortuosity factor, effective thermal conductivity, and effective electrical conductivity. A random method has been developed to compute tortuosity factors from the continuum to rarefied regimes. Representative elementary volume analysis can be performed on each property. The software also includes a time-dependent, particle-based model for the oxidation of fibrous materials. PuMA was developed for Linux operating systems and is available as a NASA software under a US & Foreign release.

  16. 1982 Naval Research Laboratory Review,

    DTIC Science & Technology

    1983-01-01

    is a principal concern of NRL manage - small, specialized laboratories. ment. The Review also serves as a resource docu- NIRL’s position is unique in...us an oppor- it was founded-people-programs-progress- tunity to assess and report our contribution to the innovation ; and that this combination will...0 vi WtL 2004020/824 *%2 J M-A b. t L ~~ SE -A COORDINATION AND DUAL Leal RSPONSIILITY MANAGEMENT DCNM NNANPRDC WOCDTNS7RDC NWC NAVSA ASK RAM

  17. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Standards for MA organization marketing. 422.2268... § 422.2268 Standards for MA organization marketing. Link to an amendment published at 76 FR 54634, Sept. 1, 2011. In conducting marketing activities, MA organizations may not— (a) Provide cash or other...

  18. Laboratory spectra of C60 and related molecular structures

    NASA Technical Reports Server (NTRS)

    Janca, J.; Solc, M.; Vetesnik, M.

    1994-01-01

    The electronic spectra of fullerene structures in high frequency discharge are studied in the plasma chemistry laboratory of the Faculty of Science of Masaryk University in Brno. The ultraviolet and visual spectra are investigated in order to be compared with the diffuse interstellar bands and interpreted within the theory of quantum mechanics. The preliminary results of the study are presented here in the form of a poster.

  19. 29. Umbrella sheds behind South Station. Boston, Suffolk Co., MA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Umbrella sheds behind South Station. Boston, Suffolk Co., MA. Sec. 4116, MP 229.50. - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  20. 5. ATTLEBORO VIADUCT: PARK STREET ARCHES. ATTLEBORO,, BRISTOL CO., MA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ATTLEBORO VIADUCT: PARK STREET ARCHES. ATTLEBORO,, BRISTOL CO., MA. Sec. 4116, MP 197.38. - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  1. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Information about the MA program. Each MA organization must provide, on an annual basis, and in a format and...

  2. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  3. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Information about the MA program. Each MA organization must provide, on an annual basis, and in a format and...

  4. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  5. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  6. MA-9 - SPLASHDOWN

    NASA Image and Video Library

    1963-05-16

    S63-09630 (16 May 1963) --- The Mercury-Atlas 9 (MA-9) "Faith 7" spacecraft, with astronaut L. Gordon Cooper Jr. aboard, nears splashdown in the Pacific Ocean to conclude a 22-orbit mission lasting 34 hours and 20.5 minutes. The capsule's parachute is fully deployed in this view. Photo credit: NASA

  7. Treatment of anti-Ma2/Ta paraneoplastic syndrome.

    PubMed

    Kraker, Jessica

    2009-01-01

    The paraneoplastic syndrome caused by Ma2/Ta antibodies alone (not in conjunction with Ma1 or Ma3 antibodies) varies in presentation from classic limbic encephalitis. The Ma2 syndrome may present with symptoms referable to the brainstem, diencephalon, and limbic system. These clinical symptoms are accompanied by MRI changes and abnormal electroencephalographic findings. It is important to recognize when the encephalitic syndrome is secondary to Ma2 paraneoplastic antibodies, as the patients improve or stabilize most often when the underlying carcinoma is treated. Treatment of the paraneoplastic syndrome begins with recognition of the symptoms, such as memory impairment, seizures, sleep disturbances, bradykinesia or hypokinesia, and eye movement abnormalities. If a primary tumor is discovered during the workup, it should be removed and treated with the most up-to-date oncologic treatment available. In addition to oncologic treatment, the syndrome may be treated with an immunosuppressant regimen to optimize the neurologic outcome. Leaving the patient untreated will result in decline and eventual death from the cancer itself or from complications of the paraneoplastic syndrome.

  8. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA plan unless the... Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c) Individuals eligible...

  9. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  10. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  11. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  12. Reconciling Conflicting Geologic and Thermochronologic Interpretations Via Multiple Apatite Thermochronometers (AHe, AFT, and 4He/3He): 6 Ma Incision of the Westernmost Grand Canyon

    NASA Astrophysics Data System (ADS)

    Winn, C.; Karlstrom, K. E.; Shuster, D. L.; Kelley, S.; Fox, M.

    2017-12-01

    The application of low-temperature apatite thermochronology to the incision history of the Grand Canyon has led to conflicting hypotheses of either a 70 Ma ("old") or <6 Ma ("young") Grand Canyon. This controversy is best captured in the westernmost segment of the Grand Canyon, where several lines of evidence favor a "young" Canyon: 1) North-derived Paleocene Hindu Fanglomerate was deposited across the present track of the Canyon; 2) The Separation Point basalt (19 Ma) is stranded between high relief tributaries and the main stem of the Colorado River; 3) Relief generation in tributaries and on plateaus adjacent to the Canyon took place after 17 Ma; and 4) The late Miocene-Pliocene Muddy Creek Formation shows that no far-traveled materials entered the Grand Wash Trough until after 6 Ma. Some interpretations of apatite thermochronology data conflict with these lines of evidence and indicate a much older ( 70 Ma) westernmost Grand Canyon. We reconcile this conflict by applying apatite (U-Th)/He ages (AHe), 4He/3He thermochronometry, and apatite fission track ages and lengths (AFT) to the same sample at a key location. Using HeFTy, t-T paths that predict these data show cooling from ˜100 °C to 40-60 °C at 70-50 Ma, long-term residence at 40-60 °C from 50-10 Ma, and cooling to surface temperatures after 10 Ma, indicating young incision. New AFT (5) and AHe (3) datasets are also presented here. When datasets are examined separately, AHe data show t-T paths that cool to surface temperatures during the Laramide, consistent with an "old" Canyon. When multiple methods are applied, t-T paths instead show young incision. This inconsistency demonstrates the age of the Grand Canyon controversy. Here we reconcile the difference in t-T paths by adjusting model parameters to account for uncertainty in the rate of radiation damage annealing in apatite during burial heating and the resulting variations in He retentivity. In this area, peak burial conditions during the Laramide

  13. Science in 60 – The Hunt for Antarctic Meteorites

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lanza, Nina

    2015-12-08

    She's the "coolest" thing in science, searching the ice sheets of Antarctica for meteorites from outer space. Los Alamos National Laboratory scientist Nina Lanza has signed up to spend nearly six weeks in a tent on the Antarctic ice sheet. Why would anyone do such a thing? For science, obviously! In the premiere episode of Los Alamos National Laboratory's "Science in 60" video series, Lanza gives us the low-down in 60 seconds on the why and how of hunting meteorites on the ice.

  14. Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

    PubMed

    Chantegrel, B; Deshayes, C; Doutheau, A; Steghens, J P

    2002-10-01

    Racemic 1,4-dihydroxynonane mercapturic acid (DHN-MA) and 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA) are synthesized on a 400-mg scale (overall yield approximately 40%) by a two-step sequence involving Michael addition of N-acetyl-L-cysteine to methyl 4-hydroxynon-2(E)-enoate or methyl 9,9,9-trideutero-4-hydroxynon-2 (E)-enoate, followed by reduction of the intermediate adducts with lithium borohydride. The requisite starting methyl esters are obtained, respectively, from heptanal or 7,7,7-trideuteroheptanal and methyl 4-chlorophenylsulfinylacetate via a sulfoxide piperidine and carbonyl reaction described in the literature. The 7,7,7-trideuteroheptanal is easily prepared by classical methods in four steps from 6-bromo-1-hexanol. 13C NMR data indicate that DHN-MA as well as d3-DHN-MA are obtained as mixtures of four diastereomers. Preliminary results show that d3-DHN-MA could be used as an internal standard for mass spectrometric quantification of DHN-MA in human urine.

  15. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  16. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  17. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  18. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  19. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  20. Tensile bond strength between auto-polymerized acrylic resin and acrylic denture teeth treated with MF-MA solution.

    PubMed

    Thongrakard, Ticha; Wiwatwarrapan, Chairat

    2016-08-01

    This study evaluated the effect of chemical surface treatment using methyl formate-methyl acetate (MF-MA) solution on the tensile bond strength between acrylic denture teeth and auto-polymerized acrylic resin. Seventy maxillary central incisor acrylic denture teeth for each of three different brands (Yamahachi New Ace; Major Dent; Cosmo HXL) were embedded with incisal edge downwards in auto-polymerized resin in polyethylene pipes and ground with silicone carbide paper on their ridge lap surfaces. The teeth of each brand were divided into seven groups (n=10): no surface treatment (control group), MF-MA solution at a ratio of 25:75 (v/v) for 15 seconds, 30 seconds, 60 seconds, 120 seconds, 180 seconds, and MMA for 180 seconds. Auto-polymerized acrylic resin (Unifast Trad) was applied to the ground surface and polymerized in a pressure cooker. A tensile strength test was performed with a universal testing machine. Statistical analysis of the results was performed using two-way analysis of variance (ANOVA) and post-hoc Dunnett T3 test (α=.05). The surface treatment groups had significantly higher mean tensile bond strengths compared with the control group (P<.05) when compared within the same brand. Among the surface treatment groups of each brand, there were no significantly different tensile bond strengths between the MF-MA groups and the MMA 180 second group (P>.05), except for the Yamahachi New Ace MF-MA 180-second group (P<.05). 15-second MF-MA solution can be an alternative chemical surface treatment for repairing a denture base and rebonding acrylic denture teeth with auto-polymerized acrylic resin, for both conventional and cross-linked teeth.

  1. The Harvard Fatigue Laboratory: Contributions to World War II

    ERIC Educational Resources Information Center

    Folk, G. Edgar

    2010-01-01

    The war contributions of the Harvard Fatigue Laboratory in Cambridge, MA, were recorded in 169 Technical Reports, most of which were sent to the Office of the Quartermaster General. Earlier reports were sent to the National Research Council and the Office of Scientific Research and Development. Many of the reports from 1941 and later dealt with…

  2. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3.

    PubMed

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([ 11 C]MA2) and a fluorine-18 ([ 18 F]MA3) labeled analog of a highly potent N -arylamide oxadiazole CB2 agonist (EC 50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC 50 : 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for h CB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC 50 values when compared to the originally reported trifluoromethyl analog 12 . [ 11 C]MA2 and [ 18 F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [ 11 C]MA2 and [ 18 F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

  3. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

    PubMed Central

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M.

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([11C]MA2) and a fluorine-18 ([18F]MA3) labeled analog of a highly potent N-arylamide oxadiazole CB2 agonist (EC50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC50: 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for hCB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC50 values when compared to the originally reported trifluoromethyl analog 12. [11C]MA2 and [18F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [11C]MA2 and [18F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted. PMID:27713686

  4. MaRIE theory, modeling and computation roadmap executive summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lookman, Turab

    The confluence of MaRIE (Matter-Radiation Interactions in Extreme) and extreme (exascale) computing timelines offers a unique opportunity in co-designing the elements of materials discovery, with theory and high performance computing, itself co-designed by constrained optimization of hardware and software, and experiments. MaRIE's theory, modeling, and computation (TMC) roadmap efforts have paralleled 'MaRIE First Experiments' science activities in the areas of materials dynamics, irradiated materials and complex functional materials in extreme conditions. The documents that follow this executive summary describe in detail for each of these areas the current state of the art, the gaps that exist and the road mapmore » to MaRIE and beyond. Here we integrate the various elements to articulate an overarching theme related to the role and consequences of heterogeneities which manifest as competing states in a complex energy landscape. MaRIE experiments will locate, measure and follow the dynamical evolution of these heterogeneities. Our TMC vision spans the various pillar science and highlights the key theoretical and experimental challenges. We also present a theory, modeling and computation roadmap of the path to and beyond MaRIE in each of the science areas.« less

  5. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Termination of contract by the MA organization. 422... Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to substantially...

  6. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Termination of contract by the MA organization. 422... Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to substantially...

  7. Relationship between methamphetamine use history and segmental hair analysis findings of MA users.

    PubMed

    Han, Eunyoung; Lee, Sangeun; In, Sanghwan; Park, Meejung; Park, Yonghoon; Cho, Sungnam; Shin, Junguk; Lee, Hunjoo

    2015-09-01

    The aim of this study was to investigate the relationship between methamphetamine (MA) use history and segmental hair analysis (1 and 3cm sections) and whole hair analysis results in Korean MA users in rehabilitation programs. Hair samples were collected from 26 Korean MA users. Eleven of the 26 subjects used cannabis with MA and two used cocaine, opiates, and MDMA with MA. Self-reported single dose of MA from the 26 subjects ranged from 0.03 to 0.5g/one time. Concentrations of MA and its metabolite amphetamine (AP) in hair were determined by gas chromatography mass spectrometry (GC/MS) after derivatization. The method used was well validated. Qualitative analysis from all 1cm sections (n=154) revealed a good correlation between positive or negative results for MA in hair and self-reported MA use (69.48%, n=107). In detail, MA results were positive in 66 hair specimens of MA users who reported administering MA, and MA results were negative in 41 hair specimens of MA users who denied MA administration in the corresponding month. Test results were false-negative in 10.39% (n=16) of hair specimens and false-positive in 20.13% (n=31) of hair specimens. In false positive cases, it is considered that after MA cessation it continued to be accumulated in hair still, while in false negative cases, self-reported histories showed a small amount of MA use or MA use 5-7 months previously. In terms of quantitative analysis, the concentrations of MA in 1 and 3cm long hair segments and in whole hair samples ranged from 1.03 to 184.98 (mean 22.01), 2.26 to 89.33 (mean 18.71), and 0.91 to 124.49 (mean 15.24)ng/mg, respectively. Ten subjects showed a good correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 7 among 10 subjects ranged from 0.71 to 0.98 (mean 0.85). Four subjects showed a low correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 4 subjects ranged from 0.36 to 0.55. Eleven subjects showed a poor

  8. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  9. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  10. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  11. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  12. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  13. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  14. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  15. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  16. Chaparral Model 60 Infrasound Sensor Evaluation.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Slad, George William; Merchant, Bion J.

    2016-03-01

    Sandia National Laboratories has tested and evaluated an infrasound sensor, the Model 60 manufactured by Chaparral Physics, a Division of Geophysical Institute of the University of Alaska, Fairbanks. The purpose of the infrasound sensor evaluation was to determine a measured sensitivity, transfer function, power, self-noise, dynamic range, and seismic sensitivity. The Model 60 infrasound sensor is a new sensor developed by Chaparral Physics intended to be a small, rugged sensor used in more flexible application conditions.

  17. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Election of coverage under an MA plan. 422.62... § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  18. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Election of coverage under an MA plan. 422.62... § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  19. Great Indian Desert photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06447 (15-16 May 1963) --- The Great Indian Desert, located west of New Delhi, India, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  20. Folsomia Candida--An Ideal Organism for Population Studies in the Laboratory

    ERIC Educational Resources Information Center

    Usher, M. B.; Stoneman, C. F.

    1977-01-01

    Folsomia candida is presented as an ideal organism for population studies that can be carried out cheaply and easily in school laboratory conditions. Means of identifying, obtaining, and culturing these organisms are described together with some indication of the kinds of investigations which can be performed. (Author/MA)

  1. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  2. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  3. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  4. 76 FR 58105 - Regulated Navigation Area; Saugus River, Lynn, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ...-AA11 Regulated Navigation Area; Saugus River, Lynn, MA AGENCY: Coast Guard, DHS. ACTION: Temporary... River in Lynn, MA. Establishing this temporary rule will allow the necessary stabilization work to be... on the Energy Systems Pipeline Bridge on the Saugus River in Lynn, MA. The regulated area encompasses...

  5. Mass and Reliability System (MaRS)

    NASA Technical Reports Server (NTRS)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  6. Mass and Reliability Source (MaRS) Database

    NASA Technical Reports Server (NTRS)

    Valdenegro, Wladimir

    2017-01-01

    The Mass and Reliability Source (MaRS) Database consolidates components mass and reliability data for all Oribital Replacement Units (ORU) on the International Space Station (ISS) into a single database. It was created to help engineers develop a parametric model that relates hardware mass and reliability. MaRS supplies relevant failure data at the lowest possible component level while providing support for risk, reliability, and logistics analysis. Random-failure data is usually linked to the ORU assembly. MaRS uses this data to identify and display the lowest possible component failure level. As seen in Figure 1, the failure point is identified to the lowest level: Component 2.1. This is useful for efficient planning of spare supplies, supporting long duration crewed missions, allowing quicker trade studies, and streamlining diagnostic processes. MaRS is composed of information from various databases: MADS (operating hours), VMDB (indentured part lists), and ISS PART (failure data). This information is organized in Microsoft Excel and accessed through a program made in Microsoft Access (Figure 2). The focus of the Fall 2017 internship tour was to identify the components that were the root cause of failure from the given random-failure data, develop a taxonomy for the database, and attach material headings to the component list. Secondary objectives included verifying the integrity of the data in MaRS, eliminating any part discrepancies, and generating documentation for future reference. Due to the nature of the random-failure data, data mining had to be done manually without the assistance of an automated program to ensure positive identification.

  7. Target Plate Material Influence on Fullerene-C60 Laser Desorption/Ionization Efficiency

    NASA Astrophysics Data System (ADS)

    Zeegers, Guido P.; Günthardt, Barbara F.; Zenobi, Renato

    2016-04-01

    Systematic laser desorption/ionization (LDI) experiments of fullerene-C60 on a wide range of target plate materials were conducted to gain insight into the initial ion formation in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The positive and negative ion signal intensities of precursor, fragment, and cluster ions were monitored, varying both the laser fluence (0-3.53 Jcm-2) and the ion extraction delay time (0-950 ns). The resulting species-specific ion signal intensities are an indication for the ionization mechanisms that contribute to LDI and the time frames in which they operate, providing insight in the (MA)LDI primary ionization. An increasing electrical resistivity of the target plate material increases the fullerene-C60 precursor and fragment anion signal intensity. Inconel 625 and Ti90/Al6/V4, both highly electrically resistive, provide the highest anion signal intensities, exceeding the cation signal intensity by a factor ~1.4 for the latter. We present a mechanism based on transient electrical field strength reduction to explain this trend. Fullerene-C60 cluster anion formation is negligible, which could be due to the high extraction potential. Cluster cations, however, are readily formed, although for high laser fluences, the preferred channel is formation of precursor and fragment cations. Ion signal intensity depends greatly on the choice of substrate material, and careful substrate selection could, therefore, allow for more sensitive (MA)LDI measurements.

  8. Target Plate Material Influence on Fullerene-C60 Laser Desorption/Ionization Efficiency.

    PubMed

    Zeegers, Guido P; Günthardt, Barbara F; Zenobi, Renato

    2016-04-01

    Systematic laser desorption/ionization (LDI) experiments of fullerene-C60 on a wide range of target plate materials were conducted to gain insight into the initial ion formation in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The positive and negative ion signal intensities of precursor, fragment, and cluster ions were monitored, varying both the laser fluence (0-3.53 Jcm(-2)) and the ion extraction delay time (0-950 ns). The resulting species-specific ion signal intensities are an indication for the ionization mechanisms that contribute to LDI and the time frames in which they operate, providing insight in the (MA)LDI primary ionization. An increasing electrical resistivity of the target plate material increases the fullerene-C60 precursor and fragment anion signal intensity. Inconel 625 and Ti90/Al6/V4, both highly electrically resistive, provide the highest anion signal intensities, exceeding the cation signal intensity by a factor ~1.4 for the latter. We present a mechanism based on transient electrical field strength reduction to explain this trend. Fullerene-C60 cluster anion formation is negligible, which could be due to the high extraction potential. Cluster cations, however, are readily formed, although for high laser fluences, the preferred channel is formation of precursor and fragment cations. Ion signal intensity depends greatly on the choice of substrate material, and careful substrate selection could, therefore, allow for more sensitive (MA)LDI measurements. Graphical Abstract ᅟ.

  9. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... availability, service area, and quality. (ii) Coordinated care plans may include mechanisms to control... requirements of sections 138 and 220 of the Internal Revenue Code. (3) MA private fee-for-service plan. An MA... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  10. HoCaMA: Home Care Hybrid Multiagent Architecture

    NASA Astrophysics Data System (ADS)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  11. United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 10. Wright Laboratory

    DTIC Science & Technology

    1993-01-01

    LABORATORIES 5800 Uplander Way Culver City, CA 90230-6608 Program Director, RDL Program Manager , AFOSR Gary Moore Col. Hal Rhoades Program Manager , RDL...Laboratory: PL/RK Aerospace Engineering University of Cinc nati Vol-Page No: 8-10 Cincinnati, OH 45221-0000 Burns, Paul Field: Electrical Engineering as...Laboratory: PL/GP Electrical Engineering Boston University Vol-Page No: a- 5 Boston, MA 2215-0000 GSRP Participant Data Stauffer, Joseph Field: Management MS

  12. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance General § 308.550 Certificate, Form MA-320. Wherever any provision of this subpart...

  13. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  14. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  15. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that...

  16. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  17. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that...

  18. In-vivo measurement of relationship between applied current amplitude and current density magnitude from 10 mA to 110 mA.

    PubMed

    DeMonte, Tim P; Wang, Dinghui; Ma, Weijing; Gao, Jia-Hong; Joy, Michael L G

    2009-01-01

    Current density imaging (CDI) is a magnetic resonance imaging (MRI) technique used to quantitatively measure current density vectors throughout the volume of an object/subject placed in the MRI system. Electrical current pulses are applied externally to the object/subject and are synchronized with the MRI sequence. In this work, CDI is used to measure average current density magnitude in the torso region of an in-vivo piglet for applied current pulse amplitudes ranging from 10 mA to 110 mA. The relationship between applied current amplitude and current density magnitude is linear in simple electronic elements such as wires and resistors; however, this relationship may not be linear in living tissue. An understanding of this relationship is useful for research in defibrillation, human electro-muscular incapacitation (e.g. TASER(R)) and other bioelectric stimulation devices. This work will show that the current amplitude to current density magnitude relationship is slightly nonlinear in living tissue in the range of 10 mA to 110 mA.

  19. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  20. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  1. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  2. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  3. Changing the S and MA [Safety and Mission Assurance] Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W., Jr.

    2010-01-01

    Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

  4. 78 FR 58882 - Safety Zone; Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ...-AA00 Safety Zone; Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION...: Chelsea River, Boston Inner Harbor, Boston, MA. Since the implementation of the regulation, physical... Chelsea, MA and East Boston, MA. Several petroleum-product transfer facilities are located on the Chelsea...

  5. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  6. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  7. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  8. Vaccines against stimulants: cocaine and MA

    PubMed Central

    Kosten, Thomas; Domingo, Coreen; Orson, Frank; Kinsey, Berma

    2014-01-01

    While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using a distinctly different mechanism of eliciting an antibody response that blocks the pharmacological effects of drugs. We provide a review of vaccine-based approaches to treating stimulant addictions; specifically and cocaine addictions. This selective review article focuses on the one cocaine vaccine that has been into clinical trials and presents new data related to pre-clinical development of a methamphetamine (MA) vaccine. We also review the mechanism of action for vaccine induced antibodies to abused drugs, which involves kinetic slowing of brain entry as well as simple blocking properties. We present pre-clinical innovations for MA vaccines including hapten design, linkage to carrier proteins and new adjuvants beyond alum. We provide some new information on hapten structures and linkers and variations in protein carriers. We consider a carrier, outer membrance polysaccharide coat protein (OMPC), that provides some self-adjuvant through lipopolysaccharide components and provide new results with a monophosopholipid adjuvant for the more standard carrier proteins with cocaine and MA. The review then covers the clinical trials with the cocaine vaccine TA-CD. The clinical prospects for advances in this field over the next few years include a multi-site cocaine vaccine clinical trial to be reported in 2013 and phase 1 clinical trials of a MA vaccine in 2014. PMID:23509915

  9. Vaccines against stimulants: cocaine and MA.

    PubMed

    Kosten, Thomas; Domingo, Coreen; Orson, Frank; Kinsey, Berma

    2014-02-01

    While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using a distinctly different mechanism of eliciting an antibody response that blocks the pharmacological effects of drugs. We provide a review of vaccine-based approaches to treating stimulant addictions; specifically and cocaine addictions. This selective review article focuses on the one cocaine vaccine that has been into clinical trials and presents new data related to pre-clinical development of a methamphetamine (MA) vaccine. We also review the mechanism of action for vaccine induced antibodies to abused drugs, which involves kinetic slowing of brain entry as well as simple blocking properties. We present pre-clinical innovations for MA vaccines including hapten design, linkage to carrier proteins and new adjuvants beyond alum. We provide some new information on hapten structures and linkers and variations in protein carriers. We consider a carrier, outer membrance polysaccharide coat protein (OMPC), that provides some self-adjuvant through lipopolysaccharide components and provide new results with a monophosopholipid adjuvant for the more standard carrier proteins with cocaine and MA. The review then covers the clinical trials with the cocaine vaccine TA-CD. The clinical prospects for advances in this field over the next few years include a multi-site cocaine vaccine clinical trial to be reported in 2013 and phase 1 clinical trials of a MA vaccine in 2014. © 2013 The British Pharmacological Society.

  10. 78 FR 48085 - Safety Zones; Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ...-AA00 Safety Zones; Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION... for the Chelsea River, Boston Inner Harbor, Boston, MA. Since the implementation of the regulation... spanned the Chelsea River providing a means for vehicles to travel between Chelsea, MA and East Boston, MA...

  11. Letrozole in the extended adjuvant setting: MA.17

    PubMed Central

    2007-01-01

    Relapse after completing adjuvant tamoxifen therapy is a persistent threat for women with hormone-responsive breast cancer. Third-generation aromatase inhibitors, such as letrozole, provide a new option for extended adjuvant hormonal therapy after 5 years of tamoxifen. MA.17 was conducted to determine whether letrozole improves outcome after discontinuation of tamoxifen. Postmenopausal women with hormone receptor-positive breast cancer (N = 5,187) were randomized to letrozole 2.5 mg or placebo once daily for 5 years. At a median follow-up of 30 months, letrozole significantly improved disease-free survival (DFS; P < 0.001), the primary end point, compared with placebo (hazard ratio [HR] for recurrence or contralateral breast cancer 0.58; 95% confidence interval [CI] 0.45, 0.76] P < 0.001). Furthermore, letrozole significantly improved distant DFS (HR = 0.60; 95% CI 0.43, 0.84; P = 0.002) and, in women with node-positive tumors, overall survival (HR = 0.61; 95% CI 0.38, 0.98; P = 0.04). Clinical benefits, including an overall survival advantage, were also seen in women who crossed over from placebo to letrozole after unblinding, indicating that tumors remain sensitive to hormone therapy despite a prolonged period since discontinuation of tamoxifen. The efficacy and safety of letrozole therapy beyond 5 years is being assessed in a re-randomization study, following the emergence of new data suggesting that clinical benefit correlates with the duration of letrozole. MA.17 showed that letrozole is extremely well-tolerated relative to placebo. Letrozole should be considered for all women completing tamoxifen; new results from the post-unblinding analysis suggest that letrozole treatment should also be considered for all disease-free women for periods up to 5 years following completion of adjuvant tamoxifen. PMID:17912635

  12. Indus River above Hyderabad photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06455 (15-16 May 1963) --- Indus River above Hyderabad, photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  13. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES..., Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may make or change his...

  14. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES..., Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may make or change his...

  15. Astronauts Carpenter and Glenn relax following breakfast during MA-6 activity

    NASA Image and Video Library

    1962-02-01

    S64-10801 (1962) --- Astronauts M. Scott Carpenter (far left) and John H. Glenn Jr. relax following breakfast during Mercury Atlas 6 (MA-6) preflight activity. Glenn is the MA-6 pilot. Carpenter is the MA-6 backup pilot. Photo credit: NASA

  16. Autoclaving practice in microbiology laboratories: report of a survey. The Public Health Laboratory Service Subcommittee on laboratory autoclaves.

    PubMed Central

    1978-01-01

    The performance of autoclaves in 27 laboratories, operated in accordance with the normal routine of local practice, has been monitored using thermometric equipment. Sterilising performance was unsatisfactory on 10 of 62 occasions, and cooling was inadequate on 52 of 60 occasions. PMID:649767

  17. Geology and complex collapse mechanisms of the 3.72 Ma Hannegan caldera, North Cascades, Washington, USA

    USGS Publications Warehouse

    Tucker, D.; Hildreth, W.; Ullrich, T.; Friedman, R.

    2007-01-01

    Contiguous ring faults of the 8 ?? 3.5 km Hannegan caldera enclose the Hannegan volcanics in the Cascade arc of northern Washington. The caldera collapsed in two phases, which each erupted rhyolitic ignimbrite (72.3%-75.2% SiO2). The first collapse phase, probably trap-door style, erupted the ???900-m-thick ignimbrite of Hannegan Peak at 3.722 ?? 0.020 Ma. This single cooling unit, generally welded, has an uppermost facies of nonwelded ignimbrite and fine ash. A short period of localized sedimentation followed. Eruption of the ignimbrite of Ruth Mountain then led to a second trap-door collapse as the first-phase partial ring fault propagated to the south to completely enclose the caldera. Wallrock breccias are intercalated as lenses and megabreccia blocks in both ignimbrites. The minimum intracaldera volume is 55-60 km3. No base is exposed, nor are outflow sheets preserved. Caldera collapse and glacial erosion have removed precaldera volcanic rocks, which survive only as intracaldera breccias. Rhyolite dikes and pods, one of which yielded a 40Ar/39Ar age of 3.72 ?? 0.34 Ma, intrude the ring fault and caldera fill. Dacite-andesite domes, dikes, and lava flows were emplaced subsequently; one lava flow gives a 40Ar/39Ar age of 2.96 ?? 0.20 Ma. The quartz diorite of Icy Peak and the granite of Nooksack Cirque (plutons with 206Pb/238U zircon ages of 3.42 ?? 0.10 Ma and 3.36 ?? 0.20 Ma, respectively) intrude caldera fill and basement rocks on the southwest margin of the caldera. Both plutons are now exceptionally well expose on high, glacially sculpted peaks within the caldera, indicating erosion of at least 1 km of intracaldera fill. Hannegan caldera anchors the northeast end of a linear NE-SW age-progressive migration of magmatic focus from the Chilliwack batholith to the active Mount Baker volcano. ?? 2006 Geological Society of America.

  18. 76 FR 77591 - Proposed Collection; Comment Request for Form 1099-MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... 1099-MA AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Form 1098-MA, Mortgage Assistance Payments. DATES: Written comments should be received on or before... INFORMATION: Title: Mortgage Assistance Payments. OMB Number: 1545-2221. Form Number: Form 1099-MA. Abstract...

  19. MaRIE 1.0: A briefing to Katherine Richardson-McDaniel, Staff Member for U. S. Senator Martin Heinrich (D-NM)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris William

    At the request of Katherine Richardson-McDaniel, Staff Member to U.S. Senator Martin Heinrich (D-NM), a high-level briefing was requested about MaRIE 1.0, the Matter-Radiation Interactions in Extremes effort at Los Alamos National Laboratory. What it would be, the mission need motivation, the scientific challenge, and the current favorable impact on both programs and people are shown in viewgraph form.

  20. MaGate Simulator: A Simulation Environment for a Decentralized Grid Scheduler

    NASA Astrophysics Data System (ADS)

    Huang, Ye; Brocco, Amos; Courant, Michele; Hirsbrunner, Beat; Kuonen, Pierre

    This paper presents a simulator for of a decentralized modular grid scheduler named MaGate. MaGate’s design emphasizes scheduler interoperability by providing intelligent scheduling serving the grid community as a whole. Each MaGate scheduler instance is able to deal with dynamic scheduling conditions, with continuously arriving grid jobs. Received jobs are either allocated on local resources, or delegated to other MaGates for remote execution. The proposed MaGate simulator is based on GridSim toolkit and Alea simulator, and abstracts the features and behaviors of complex fundamental grid elements, such as grid jobs, grid resources, and grid users. Simulation of scheduling tasks is supported by a grid network overlay simulator executing distributed ant-based swarm intelligence algorithms to provide services such as group communication and resource discovery. For evaluation, a comparison of behaviors of different collaborative policies among a community of MaGates is provided. Results support the use of the proposed approach as a functional ready grid scheduler simulator.

  1. Science in 60 – The Hunt for Antarctic Meteorites

    ScienceCinema

    Lanza, Nina

    2018-01-16

    She's the "coolest" thing in science, searching the ice sheets of Antarctica for meteorites from outer space. Los Alamos National Laboratory scientist Nina Lanza has signed up to spend nearly six weeks in a tent on the Antarctic ice sheet. Why would anyone do such a thing? For science, obviously! In the premiere episode of Los Alamos National Laboratory's "Science in 60" video series, Lanza gives us the low-down in 60 seconds on the why and how of hunting meteorites on the ice.

  2. Oxide-dispersion-strengthened turbine blades, volume 1. [MA6000 alloy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Millan, P.P. Jr.; Mays, J.C.

    1986-10-01

    The objective of Project 4 was to develop a high-temperature, uncooled gas turbine blade using MA6000 alloy. The program objectives were achieved. Production scale up of the MA6000 alloy was achieved with a fair degree of tolerance to nonoptimum processing. The blade manufacturing process was also optimized. The mechanical, environmental, and physical property evaluations of MA6000 were conducted. The ultimate tensile strength, to about 704 C (130 F), is higher than DS MAR-M 247 but with a corresponding lower tensile elongation. Also, above 982 C (180 F) MA6000 tensile strength does not decrease as rapidly as MAR-M 247 because themore » ODS mechanism still remains active. Based on oxidation resistance and diffusional stability considerations, NiCrAlY coatings are recommended. CoCrAly coating should be applied on top of a thin NiCrAlY coating. Vibration tests, whirlpit tests, and a high-rotor-rig test were conducted to ensure successful completion of the engine test of the MA6000 TFE731 high pressure turbine blades. The results of these tests were acceptable. In production quantities, the cost of the Project 4 MA6000 blade is estimated to be about twice that of a cast DS MAR-M 247 blade.« less

  3. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  4. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  5. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  6. In-cell RNA structure probing with SHAPE-MaP.

    PubMed

    Smola, Matthew J; Weeks, Kevin M

    2018-06-01

    This protocol is an extension to: Nat. Protoc. 10, 1643-1669 (2015); doi:10.1038/nprot.2015.103; published online 01 October 2015RNAs play key roles in many cellular processes. The underlying structure of RNA is an important determinant of how transcripts function, are processed, and interact with RNA-binding proteins and ligands. RNA structure analysis by selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) takes advantage of the reactivity of small electrophilic chemical probes that react with the 2'-hydroxyl group to assess RNA structure at nucleotide resolution. When coupled with mutational profiling (MaP), in which modified nucleotides are detected as internal miscodings during reverse transcription and then read out by massively parallel sequencing, SHAPE yields quantitative per-nucleotide measurements of RNA structure. Here, we provide an extension to our previous in vitro SHAPE-MaP protocol with detailed guidance for undertaking and analyzing SHAPE-MaP probing experiments in live cells. The MaP strategy works for both abundant-transcriptome experiments and for cellular RNAs of low to moderate abundance, which are not well examined by whole-transcriptome methods. In-cell SHAPE-MaP, performed in roughly 3 d, can be applied in cell types ranging from bacteria to cultured mammalian cells and is compatible with a variety of structure-probing reagents. We detail several strategies by which in-cell SHAPE-MaP can inform new biological hypotheses and emphasize downstream analyses that reveal sequence or structure motifs important for RNA interactions in cells.

  7. Texture and anisotropy of the mechanical properties of MA14 and MA2-1 alloys produced by granular metallurgy

    NASA Astrophysics Data System (ADS)

    Betsofen, S. Ya.; Konkevich, V. Yu.; Osintsev, O. E.; Avdyukhina, A. A.; Voskresenskaya, I. I.; Grushin, I. A.

    2015-10-01

    The contribution of texture to the anisotropy of the mechanical properties of semifinished products from MA14 and MA2-1 alloys prepared by capsule-free pressing of granules is quantitatively evaluated using inverse pole figures and calculated Taylor orientation factors for basal slip. It is shown that the texture intensity and the anisotropy of the mechanical properties of the pressed semiproducts are lower than those of the semiproducts from an ingot and the compressive yield strength is substantially higher.

  8. The Marshall Grazing Incidence X-ray Spectrometer (MaGIXS)

    NASA Astrophysics Data System (ADS)

    Winebarger, A. R.; Savage, S. L.; Kobayashi, K.; Champey, P. R.; McKenzie, D. E.; Golub, L.; Testa, P.; Reeves, K.; Cheimets, P.; Cirtain, J. W.; Walsh, R. W.; Bradshaw, S. J.; Warren, H.; Mason, H. E.; Del Zanna, G.

    2017-12-01

    For over four decades, X-ray, EUV, and UV spectral observations have been used to measure physical properties of the solar atmosphere. At wavelengths below 10 nm, however, observations of the solar corona with simultaneous spatial and spectral resolution are limited, and not since the late 1970's have spatially resolved solar X-ray spectra been measured. Because the soft X-ray regime is dominated by emission lines formed at high temperatures, X-ray spectroscopic techniques yield insights to fundamental physical processes that are not accessible by any other means. Using a novel implementation of corrective optics, the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS) will measure, for the first time, the solar spectrum from 0.6- 2.4 nm with a 6 arcsec resolution over an 8 arcmin slit. The MaGIXS mission will address on of the fundamental problems of coronal physics: the nature of coronal heating. There are several observables in the MaGIXS wavelength range that will constrain the heating frequency and hence discriminate between competing coronal heating theories. In this presentation, we will present the MaGIXS scientific motivation and provide an update on instrument development. MaGIXS will be launched from White Sands Missile Range in the summer of 2019.

  9. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

    PubMed Central

    Yue, Kan; Santiago, Grissel Trujillo-de; Alvarez, Mario Moisés; Tamayol, Ali; Annabi, Nasim; Khademhosseini, Ali

    2015-01-01

    Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing. PMID:26414409

  10. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Continuation of enrollment for MA local plans. 422... Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a local plan furnishes...

  11. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Continuation of enrollment for MA local plans. 422... Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a local plan furnishes...

  12. Creep shear behavior of the oxide dispersion strengthened superalloy MA 6000E

    NASA Technical Reports Server (NTRS)

    Glasgow, T. K.

    1981-01-01

    The shear rupture life of the oxide dispersion strengthened (ODS) superalloy MA 6000E was determined at 650 and 760 C was 250 MPa. Comparisons were made at 760 C with the conventional cast superalloy B-1900+Hf, the ODS alloy MA 754, and the directionally solidified eutectic alloy gamma/gamma prime-delta was 170 MPa, and for B-1900+Hf was 360 MPa. The ODS alloy MA 6000E and gamma/gamma prime-delta failed with very little indication of ductile accommodation. Both MA 754 and B-1900+Hf showed some ductile tearing. Fracture surfaces of the ODS alloy MA 754 showed discontinuities similar size, shape, and roughness to its grain structure, but the fracture surfaces of MA 6000E were much smoother than its grain boundaries.

  13. MaGa, a web-based collaborative database for gas emissions: a tool to improve the knowledge on Earth degassing

    NASA Astrophysics Data System (ADS)

    Frigeri, A.; Cardellini, C.; Chiodini, G.; Frondini, F.; Bagnato, E.; Aiuppa, A.; Fischer, T. P.; Lehnert, K. A.

    2014-12-01

    The study of the main pathways of carbon flux from the deep Earth requires the analysis of a large quantity and variety of data on volcanic and non-volcanic gas emissions. Hence, there is need for common frameworks to aggregate available data and insert new observations. Since 2010 we have been developing the Mapping Gas emissions (MaGa) web-based database to collect data on carbon degassing form volcanic and non-volcanic environments. MaGa uses an Object-relational model, translating the experience of field surveyors into the database schema. The current web interface of MaGa allows users to browse the data in tabular format or by browsing an interactive web-map. Enabled users can insert information as measurement methods, instrument details as well as the actual values collected in the field. Measurements found in the literature can be inserted as well as direct field observations made by human-operated instruments. Currently the database includes fluxes and gas compositions from active craters degassing, diffuse soil degassing and fumaroles both from dormant volcanoes and open-vent volcanoes from literature survey and data about non-volcanic emission of the Italian territory. Currently, MaGa holds more than 1000 volcanic plume degassing fluxes, data from 30 sites of diffuse soil degassing from italian volcanoes, and about 60 measurements from fumarolic and non volcanic emission sites. For each gas emission site, the MaGa holds data, pictures, descriptions on gas sampling, analysis and measurement methods, together with bibliographic references and contacts to researchers having experience on each site. From 2012, MaGa developments started to be focused towards the framework of the Deep Earth Carbon Degassing research initiative of the Deep Carbon Observatory. Whithin the DECADE initiative, there are others data systems, as EarthChem and the Smithsonian Institution's Global Volcanism Program. An interoperable interaction between the DECADE data systems is being

  14. Network Management and FDIR for SpaceWire Networks (N-MaSS)

    NASA Astrophysics Data System (ADS)

    Montano, Giuseppe; Jameux, David; Cook, Barry; Peel, Rodger; McCormick, Ecaterina; Walker, Paul; Kollias, Vangelis; Pogkas, Nikos

    2014-08-01

    The SpaceWire network management layer, which manages network topology and routing, is not yet standardised. This paper presents the European Space Agency (ESA) N-MaSS study, which focuses on implementation and standardisation of Fault Detection, Isolation and Recovery (FDIR) functions within the SpaceWire network management layer. N-MaSS provides an autonomous FDIR solution. It is defined at the SpaceWire network layer in order to achieve efficient re-use for heterogeneous missions, allowing for the incorporation of legacy equipment. The N-MaSS FDIR functions identify SpaceWire link and node failures and provide recovery using redundant nodes.This paper provides an overview of the overall N- MaSS study. In particular, the following topics are discussed: (a) how user requirements have been captured from the industry, SpaceWire Working Group and ESA; (b) how the N-MaSS architecture was organically shaped on the basis of the requirements captured; (c) how the N-MaSS concept is currently being implemented in a demonstrator and verified.

  15. Diet of Theropithecus from 4 to 1 Ma in Kenya

    PubMed Central

    Cerling, Thure E.; Chritz, Kendra L.; Jablonski, Nina G.; Leakey, Meave G.; Manthi, Fredrick Kyalo

    2013-01-01

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0–2.5 Ma) and T. oswaldi (2.0–1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets. PMID:23733967

  16. The Harvard Fatigue Laboratory: contributions to World War II.

    PubMed

    Folk, G Edgar

    2010-09-01

    The war contributions of the Harvard Fatigue Laboratory in Cambridge, MA, were recorded in 169 Technical Reports, most of which were sent to the Office of the Quartermaster General. Earlier reports were sent to the National Research Council and the Office of Scientific Research and Development. Many of the reports from 1941 and later dealt with either physical fitness of soldiers or the energetic cost of military tasks in extreme heat and cold. New military emergency rations to be manufactured in large quantities were analyzed in the Fatigue Laboratory and then tested in the field. Newly designed cold weather clothing was tested in the cold chamber at -40 degrees F, and desired improvements were made and tested in the field by staff and soldiers in tents and sleeping bags. Electrically heated clothing was designed for high-altitude flight crews and tested both in laboratory chambers and field tests before being issued. This eye witness account of the Harvard Fatigue Laboratory during World War II was recorded by Dr. G. Edgar Folk, who is likely the sole surviving member of that famous laboratory.

  17. The Construction of the Siam Photon Laboratory and Its Ripple Effects

    NASA Astrophysics Data System (ADS)

    Ishii, Takehiko

    2004-03-01

    The Siam Photon Laboratory of the National Synchrotron Research Center(NSRC) is a synchrotron radiation research facility built for promoting the scientific and technological research activity of the country and enhancing the human resources development. The accelerator complex was originally owned by the SORTEC Laboratory in Tsukuba and transferred to NSRC gratis. The storage ring design was renewed and the construction of the whole accelerator complex with the reformed storage ring was completed two years ago. In the course of the construction, we found many problems distinctive of second hand machines. The maximum stored current and the beam lifetime at present are 210mA and 6hr at 100mA, respectively. One beam line for photoemission experiments has been opened to outside users. First experimental studies made on Ni(111) by our staff members has been completed. Since the project started from scratch, NSRC was asked to carry out all work necessary for opening the facility to outside users, The work includes collecting users and setting up the users organization. In industrial applications, for instance, we have to find either some government or private sectors who are interested in the fundamantal technological research using synchrotorn radiation. Then, the training of users from the relevant organizations will start. After the establishment of the Siam Photon Laboratory, the trend of the promotion of pertinent research has increased. More fundamental human resources development including the graduate school education is underway around the Siam Photon Laboratory. The growth of enterprises as a part of the infrastructure is slow but steady.

  18. Fullerene C60 coated silicon nanowires as anode materials for lithium secondary batteries.

    PubMed

    Arie, Arenst Andreas; Lee, Joong Kee

    2012-04-01

    A Fullerene C60 film was introduced as a coating layer for silicon nanowires (Si NWs) by a plasma assisted thermal evaporation technique. The morphology and structural characteristics of the materials were studied by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). SEM observations showed that the shape of the nanowire structure was maintained after the C60 coating and the XPS analysis confirmed the presence of the carbon coating layer. The electrochemical characteristics of C60 coated Si NWs as anode materials were examined by charge-discharge tests and electrochemical impedance measurements. With the C60 film coating, Si NW electrodes exhibited a higher initial coulombic efficiency of 77% and a higher specific capacity of 2020 mA h g(-1) after the 30th cycle at a current density of 100 microA cm(-2) with cut-off voltage between 0-1.5 V. These improved electrochemical characteristics are attributed to the presence of the C60 coating layer which suppresses side reaction with the electrolyte and maintains the structural integrity of the Si NW electrodes during cycle tests.

  19. 12. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF POWER HOUSE EQUIPMENT. Drawing No. 9053. Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  20. 14. Power copy of drawing, August 21, 1915. POWER PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Power copy of drawing, August 21, 1915. POWER PLANT EXTENSION, GENERAL PLANS. Drawing No. 4415, Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  1. 13. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photo copy of drawing, Feb. 5, 1912. ARRANGEMENT OF POWER HOUSE EQUIPMENT. Drawing No. 9053. Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  2. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  3. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  4. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  5. Tibetan Plateau photographed during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06440 (15-16 May 1963) --- View of the Tibetan Plateau in north-central Tibet, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. The center of the photograph is near 91 degrees east longitude and 34 degrees 30 minutes north latitude. This view includes lakes and snow-covered highlands. Photo credit: NASA

  6. Convective removal of the Tibetan Plateau mantle lithosphere by 26 Ma

    NASA Astrophysics Data System (ADS)

    Lu, Haijian; Tian, Xiaobo; Yun, Kun; Li, Haibing

    2018-04-01

    During the late Oligocene-early Miocene there were several major geological events in and around the Tibetan Plateau (TP). First, crustal shortening deformation ceased completely within the TP before 25 Ma and instead adakitic rocks and potassic-ultrapotassic volcanics were emplaced in the Lhasa terrane since 26-25 Ma. Several recent paleoelevation reconstructions suggest an Oligocene-early Miocene uplift of 1500-3000 m for the Qiangtang (QT) and Songpan-Ganzi (SG) terranes, although the exact timing is unclear. As a possible response to this uplift, significant desertification occurred in the vicinity of the TP at 26-22 Ma, and convergence between India and Eurasia slowed considerably at 26-20 Ma. Subsequently, E-W extension was initiated no later than 18 Ma in the Lhasa and QT terranes. In contrast, the tectonic deformation around the TP was dominated by radial expansion of shortening deformation since 25-22 Ma. The plateau-wide near-synchroneity of these events calls for an internally consistent model which can be best described as convective removal of the lower mantle lithosphere. Geophysical and petrochemical evidence further confirms that this extensive removal occurred beneath the QT and SG terranes. The present review concludes that, other than plate boundary stress, the internal stress within the TP lithosphere could have contributed to rapid wholesale uplift and a series of concomitant tectonic events, accompanied by major aridification, since 26 Ma.

  7. Expanding pore sizes of ZIF-8-derived nitrogen-doped microporous carbon via C60 embedding: toward improved anode performance for the lithium-ion battery.

    PubMed

    Guan, Jian; Zhong, Xiongwu; Chen, Xiang; Zhu, Xianjun; Li, Panlong; Wu, Jianhua; Lu, Yalin; Yu, Yan; Yang, Shangfeng

    2018-02-01

    Porous carbon and nanocarbons have been extensively applied as anode materials for high-energy density lithium-ion batteries (LIBs). However, as another representative nanocarbon, fullerenes, such as C 60 , have been scarcely utilized in LIBs because of their poor electrochemical reversibility. Herein, we designed a novel C 60 -embedded nitrogen-doped microporous carbon material (denoted as C 60 @N-MPC), which was derived from a zeolitic imidazolate framework-8 (ZIF-8) precursor, demonstrating its promising application as a superior anode material for LIB. We first embedded C 60 in situ into a ZIF-8 matrix via a facile solid-state mechanochemical route, which acted as a precursor and was transformed to C 60 @N-MPC after carbonization. The C 60 @N-MPC was applied as a novel anode for LIBs, showing an improved reversible specific capacity of ≈1351 mA h g -1 at 0.1 A g -1 and a better rate capacity (≈1077 mA h g -1 at 1 A g -1 after 400 cycles) relative to those based on the unmodified N-MPC anode. The role of C 60 in the superior lithium storage performance of C 60 @N-MPC was elucidated, revealing that C 60 functioned as a pore expander for N-MPC with 3-20 nm mesopores (versus sub-1 nm micropores for the unmodified N-MPC), which facilitated the rapid diffusion of the organic electrolyte.

  8. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Closing report, Form MA-313. 308.533 Section 308.533 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313. This...

  9. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

  10. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

  11. MaRGEE: Move and Rotate Google Earth Elements

    NASA Astrophysics Data System (ADS)

    Dordevic, Mladen M.; Whitmeyer, Steven J.

    2015-12-01

    Google Earth is recognized as a highly effective visualization tool for geospatial information. However, there remain serious limitations that have hindered its acceptance as a tool for research and education in the geosciences. One significant limitation is the inability to translate or rotate geometrical elements on the Google Earth virtual globe. Here we present a new JavaScript web application to "Move and Rotate Google Earth Elements" (MaRGEE). MaRGEE includes tools to simplify, translate, and rotate elements, add intermediate steps to a transposition, and batch process multiple transpositions. The transposition algorithm uses spherical geometry calculations, such as the haversine formula, to accurately reposition groups of points, paths, and polygons on the Google Earth globe without distortion. Due to the imminent deprecation of the Google Earth API and browser plugin, MaRGEE uses a Google Maps interface to facilitate and illustrate the transpositions. However, the inherent spatial distortions that result from the Google Maps Web Mercator projection are not apparent once the transposed elements are saved as a KML file and opened in Google Earth. Potential applications of the MaRGEE toolkit include tectonic reconstructions, the movements of glaciers or thrust sheets, and time-based animations of other large- and small-scale geologic processes.

  12. MaRIE: an experimental facility concept revolutionizing materials in extremes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris W

    The Matter-Radiation Interactions in Extremes (MaRIE) project intends to create an experimental facility that will revolutionize the control of materials in extremes. That control extends to extreme regimes where solid material has failed and begins to flow - the regimes of fluid dynamics and turbulent mixing. This presentation introduces the MaRIE facility concept, demonstrates examples of the science case that determine its functional requirements, and kicks-off the discussion of the decadal scientific challenges of mixing in extremes, including those MaRIE might address.

  13. Analysis of rocks particulates by VNIR spectroscopy with Ma_Miss instrument breadboard.

    NASA Astrophysics Data System (ADS)

    De Angelis, Simone; Altieri, Francesca; Giardino, Marco; Ammannito, Eleonora; Carli, Cristian; Frigeri, Alessandro; De Sanctis, Maria Cristina

    Ma_Miss (Mars Multispectral Imager for Subsurface Studies) miniaturized spectrometer will investigate the Martian subsurface in the Visible and Near Infrared spectral range 0.4-2.2 mum, with 120 mum spatial resolution, and 20 nm of spectral resolution. It will be integrated in the Drill of the Pasteur Rover of the ExoMars 2018 mission, and will acquire spectra of the borehole wall performed by the Drill in the subsoil, at depths down to 2 meters. The main objective of Exomars mission is the search of present or past life and the investigation about the conditions favourable to the development of life. So the characterization of the possible water geochemical environment is the primary goal: thus objectives will be the search for hydrated silicates as well as carbonate or sulphate layers. The goal of Ma_Miss is the study of the Martian subsurface, and its principal scientific objectives are: the determination of the subsurface mineralogy and the reconstraction of a stratigraphic column or sequence, by means of Visible and Near Infrared reflectance spectroscopy; the characterization of physical properties of materials. The instrument breadboard is operative at the IAPS/INAF laboratory; it consists of the main subsystems except the spectrometer, that is a commercial spectrometer (FieldSpec Pro ©): a 5 W lamp supplies the illumination; an optical fibres bundle carries the light from the lamp to the Optical Head, which has the double task of focusing the light on the observed target and of collecting the scattered light from the target. The illumination spot on the target is 1 mm in diameter, while the light is recollected from a 120-mum spot. A single optical fibre carries the collected light from the Optical Head to the spectrometer. The interface between the Optical Head and the external wall is the Sapphire Window, which has high hardness and transparency. The light is focused on the wall at a distance of less than 1 mm outside the Sapphire Window. In this work

  14. Influence of surface light scattering in hydrophobic acrylic intraocular lenses on laser beam transmittance.

    PubMed

    Shiraya, Tomoyasu; Kato, Satoshi; Minami, Keiichiro; Miyata, Kazunori

    2017-02-01

    The aim of this study was to experimentally examine the changes in the transmittances of photocoagulation lasers when surface light scattering increases in AcrySof intraocular lenses (IOLs). SA60AT IOLs (Alcon) were acceleratingly aging for 0, 3, 5, and 10 years to simulate surface light scattering, and the surface light-scattering intensities of both IOL surfaces were measured using a Scheimpflug photographer. The powers of laser beams that passed from a laser photocoagulator through the aged IOLs were measured at 532, 577, and 647 nm. Changes in the laser power and transmittance with the years of aging and the intensities of surface light scattering were examined. Although the intensity of surface light scattering increased with the years of aging, the laser power did not change with the years of aging (P > 0.30, Kruskal-Wallis test). There were no significant changes in the laser transmittance with the years of aging or the laser wavelength (P > 0.30 and 0.57, respectively). The intensity of surface light scattering revealed no significant association with the laser transmittance at any wavelength (P > 0.37, liner regression). The increases in the surface light scattering of the AcrySof IOLs would not influence retinal photocoagulation treatments for up to 10 years after implantation.

  15. Evaluation of Optical Quality: Ocular Scattering and Aberrations in Eyes Implanted with Diffractive Multifocal or Monofocal Intraocular Lenses.

    PubMed

    Liao, Xuan; Lin, Jia; Tian, Jing; Wen, BaiWei; Tan, QingQing; Lan, ChangJun

    2018-06-01

    To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes from 57 cataract patients were bilaterally or unilaterally implanted with monofocal (AcrySof IQ SN60WF) or multifocal (AcrySof IQ ReSTOR SN6AD1) IOLs. Respectively, 40 eyes of 27 patients were implanted with monofocal IOLs, and 40 eyes of 30 patients were implanted with multifocal IOLs. Ocular high-order aberration (HOA) values were obtained using Hartmann-Shack aberrometer; objective scatter index (OSI), modulation transfer function (MTF) cutoff, Strehl ratio (SR), and contrast visual acuity OV at 100%, 20%, and 9% were measured using Objective Quality Analysis System II (OQAS II). Ocular aberrations performed similar in both groups (p > 0.05). However, significantly higher values of OSI and lower values of MTF cutoff, SR and OV were found in the SN6AD1 group (p < 0.05). Both ocular scattering and wave-front aberrations play essential role in retinal image quality, which may be overestimated when only aberrations were taken into account. Combining the effect of ocular scattering with HOA will result in a more accurate assessment of the visual and optical quality.

  16. 15. Power copy of drawing, August 21, 1915. POWER PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Power copy of drawing, August 21, 1915. POWER PLANT EXTENSION, GENERAL PLANS. Drawing No. PA-A-36692, Facilities Engineering, Army Materials Technology Laboratory, Watertown, Massachusetts. - Watertown Arsenal, Building No. 60, Arsenal Street, Watertown, Middlesex County, MA

  17. MERCURY-ATLAS (MA)-9 - ASTRONAUT COOPER - EARTH-SKY VIEW - TIBET

    NASA Image and Video Library

    1963-05-15

    S63-06454 (15-16 May 1963) --- Tibetan Lake Country North of Katmandu, west of Ihasa, photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  18. Exploring African Aridification and Wet/dry Cycles Over the Last 3 MA

    NASA Astrophysics Data System (ADS)

    Meyers, C.; Tierney, J. E.; DeMenocal, P. B.

    2011-12-01

    Marine sediment records document a gradual increase in aeolian dust supply from Africa over the last 3 Ma in the Atlantic, Gulf of Aden, and Mediterranean (Larrasoaña et al., 2003, deMenocal 2004), with 'steps' in period and amplitude at ~2.8 Ma, ~1.7 Ma, and ~1.0 Ma. However, Mediterranean sapropel sequences document regular, precession-paced wet/dry cycles from changes in the strength of the African monsoon and Nile runoff since at least the Miocene (Rossignol-Strick, 1985, Krijgsman et al., 1995, Lourens et al., 1996). The influence of long-term drying trends in Africa on the movements and strength of the African monsoon over the late Pliocene and Pleistocene is not understood. We have constructed a biomarker-based African climate record by analyzing concentrations and δ D from long-chain, saturated fatty acid methyl esters (FAMEs) in eastern Mediterranean ODP Site 967 sediments from 2.8 - 3.1 Ma and 1.6 - 1.8 Ma. Long-chain fatty acids are produced in the leaf waxes of terrestrial plants (Eglinton and Hamilton, 1967) and are transported to marine sediments via aeolian and fluvial action. Sapropel sediments corresponding with precession minima and enhanced Nile River runoff (Rossignol-Strick, 1985) contain much higher concentrations of FAMEs than carbonate-rich sediments. Comparisons of the two intervals will be presented to illustrate changes in monsoon strength from 3 Ma to 1.6 Ma.

  19. Monitoring tectonic uplift and paleoenvironmental reconstruction for marine terraces near Maǧaracik and Samandaǧ, Hatay Province, Turkey.

    PubMed

    Florentin, Jonathan A; Blackwell, Bonnie A B; Tüysüz, Okan; Tarı, Ufuk; Can Genç, Ş; İmren, Caner; Mo, Shirley; Huang, Yiwen E W; Blickstein, Joel I B; Skinner, Anne R; Kim, Maria

    2014-06-01

    Near Hatay, the Antakya-Samandağ-Cyprus Fault (ASCF), East Anatolian and Dead Sea Fault Zones, the large faults that form the edges of the African, Anatolian, Cyprus and Arabian Plates, all produce large earthquakes, which have decimated Hatay repeatedly. Near Samandağ, Hatay, differential vertical displacement on the ASCF has uplifted the southeastern side relative to northwestern side, producing large fault scarps that parallel the Asi (Orontes) River. Tectonic uplift coupled with Quaternary sealevel fluctuations has produced several stacked marine terraces stranded above current sealevel. This study dated 24 mollusc samples from 10 outcrops on six marine terraces near Samandağ electron spin resonance (ESR). Ages were calculated using time-averaged and volumetrically averaged external dose rates, modelled by assuming typical water depths for the individual species and sediment thicknesses estimated from geological criteria. Uplift rates were then calculated for each fault block. At all the Mağaracık terraces, the dates suggest that many shells were likely reworked. On the 30 m terrace at Mağaracık IV (UTM 766588-3999880), Lithophagus burrows with in situ shells cross the unconformity. One such shell dated to 62 ± 6 ka, setting the minimum possible age for the terrace. For all the Mağaracık terraces at ∼30 m above mean sealevel (amsl), the youngest ages for the reworked shells, which averaged 60 ± 3 ka for six separate analyses, sets the maximum possible age for this unit. Thus, the terrace must date to 60-62 ± 3 ka, at the MIS 3/4 boundary when temperatures and sealevels were fluctuating rapidly. Older units dating to MIS 7, 6, and 5 likely were being eroded to supply some fossils found in this terrace. At Mağaracık Dump (UTM 765391-4001048), ∼103 m amsl, Ostrea and other shells were found cemented in growth position to the limestone boulders outcropping there <2.0 m above a wave-eroded notch. If the oysters grew at the same time as the wave

  20. Consecutive C[subscript 60] Fullerene Dissociation from Ir([eta][superscript 2]-C[subscript 60])(CO)(Cl)(PPh[subscript 3])[subscript 2] and the Oxidative Addition of Benzene

    ERIC Educational Resources Information Center

    Felix, Tamara; Cortes-Figueroa, Jose E.

    2010-01-01

    This laboratory activity is a mechanistic exploration of the interactions between electronically deficient organometallic compounds and solvent molecules. Simple kinetics experiments designed to explore the mechanism of C[subscript 60] fullerene-benzene exchange on Ir(([eta][superscript 2]-C[subscript 60])(CO)(Cl)(PPh[subscript 3])[subscript 2]…

  1. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    NASA Astrophysics Data System (ADS)

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-08-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10-20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules.

  2. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    PubMed Central

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-01-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10–20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules. PMID:27503340

  3. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  4. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  5. Secondary membrane formation after cataract surgery with primary intraocular lens implantation in children.

    PubMed

    Bar-Sela, Shai M; Har-Noy, Nurit Birman; Spierer, Abraham

    2014-08-01

    To evaluate the risk factors for secondary membrane (SM) formation after congenital cataract surgery with intraocular lens (IOL) implantation. A retrospective non-interventional comparative study. Thirty-nine patients (63 eyes) aged 1-135 months. The study included patients who underwent cataract extraction and primary IOL implantation between 1994 and 2001 at the University Hospital. The postoperative follow-up was 6-24 months. Thirty-three eyes received a poly(methyl methacrylate) (PMMA) IOL without square edges, 29 eyes received a hydrophobic acrylic IOL with truncated square edges (AcrySof), and there was no data for IOL type in one eye. Thirty-nine eyes had primary posterior capsulotomy (PPC) and anterior vitrectomy (AV) and in 24 eyes the posterior capsule was left intact. Cox proportional hazard regression analysis was performed to identify significant risk factors for SM formation, and Wilcoxon test to evaluate the difference in time from surgery to SM formation. SM developed in 24 eyes (38 %)--58 % of eyes with an intact posterior capsule and 26 % of eyes having PPC and AV, 42 % of eyes with a PMMA IOL, and 34 % of eyes with an AcrySof lens. In multivariate Cox regression analysis intraoperative PPC and AV (P = 0.02) and AcrySof lens implantation (P = 0.097) were associated with decreased postoperative incidence of SM formation. Median time until SM development was 2.9 months with PMMA IOLs (range 1-17 months) and 6 months with AcrySof lenses (range 1-21.8 months) (P = 0.037). Posterior capsule management as well as IOL design and material influence the incidence and the timing of SM formation after primary IOL implantation in children.

  6. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  7. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  8. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  9. The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study

    PubMed Central

    Ray, Lara A; Bujarski, Spencer; Courtney, Kelly E; Moallem, Nathasha R; Lunny, Katy; Roche, Daniel; Leventhal, Adam M; Shoptaw, Steve; Heinzerling, Keith; London, Edythe D; Miotto, Karen

    2015-01-01

    Methamphetamine (MA) use disorder is a serious psychiatric condition for which there are no FDA-approved medications. Naltrexone (NTX) is an opioid receptor antagonist with demonstrated efficacy, albeit moderate, for the treatment of alcoholism and opioid dependence. Preclinical and clinical studies suggest that NTX may be useful for the treatment of MA use disorder. To inform treatment development, we conducted a double-blind, randomized, crossover, placebo-controlled human laboratory study of NTX. Non-treatment-seeking individuals meeting DSM-IV criteria for MA abuse or dependence (n=30) completed two separate 5-day inpatient stays. During each admission, participants completed testing sessions comprised of MA cue-reactivity and intravenous MA administration (30 mg) after receiving oral NTX (50 mg) or placebo for 4 days. This study tested the hypotheses that NTX would (a) attenuate cue-induced MA craving, and (b) reduce subjective responses to MA administration. Results largely supported the study hypotheses such that (a) NTX significantly blunted cue-induced craving for MA and (b) attenuated several of the hedonic subjective effects of MA, including craving, during controlled MA administration and as compared with placebo. NTX decreased overall subjective ratings of ‘crave drug,' ‘stimulated,' and ‘would like drug access,' decreased the the post-MA administration timecourse of ‘anxious' and increased ratings of ‘bad drug effects,' as compared with placebo. These findings support a potential mechanism of action by showing that NTX reduced cue-induced craving and subjective responses to MA. This is consistent with positive treatment studies of NTX for amphetamine dependence, as well as ongoing clinical trials for MA. PMID:25801501

  10. 78 FR 6782 - Safety Zone-Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ...-AA00 Safety Zone--Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION....120, Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. This advance notice allows the Coast... Commercial Street, Boston, MA 02109: March 6, 2013, from 11:00 a.m. to 12:00 p.m.; April 24, 2013, from 11:00...

  11. 6 Ma age of carving Westernmost Grand Canyon: Reconciling geologic data with combined AFT, (U-Th)/He, and 4He/3He thermochronologic data

    NASA Astrophysics Data System (ADS)

    Winn, Carmen; Karlstrom, Karl E.; Shuster, David L.; Kelley, Shari; Fox, Matthew

    2017-09-01

    Conflicting hypotheses about the timing of carving of the Grand Canyon involve either a 70 Ma (;old;) or <6 Ma (;young;) Grand Canyon. This paper evaluates the controversial westernmost segment of the Grand Canyon where the following lines of published evidence firmly favor a ;young; Canyon. 1) North-derived Paleocene Hindu Fanglomerate was deposited across the present track of the westernmost Grand Canyon, which therefore was not present at ∼55 Ma. 2) The 19 Ma Separation Point basalt is stranded between high relief side canyons feeding the main stem of the Colorado River and was emplaced before these tributaries and the main canyon were incised. 3) Geomorphic constraints indicate that relief generation in tributaries and on plateaus adjacent to the westernmost Grand Canyon took place after 17 Ma. 4) The late Miocene-Pliocene Muddy Creek Formation constraint shows that no river carrying far-traveled materials exited at the mouth of the Grand Canyon until after 6 Ma. Interpretations of previously-published low-temperature thermochronologic data conflict with these lines of evidence, but are reconciled in this paper via the integration of three methods of analyses on the same sample: apatite (U-Th)/He ages (AHe), 4He/3He thermochronometry (4He/3He), and apatite fission-track ages and lengths (AFT). HeFTy software was used to generate time-temperature (t-T) paths that predict all new and published 4He/3He, AHe, and AFT data to within assumed uncertainties. These t-T paths show cooling from ∼100 °C to 40-60 °C in the Laramide (70-50 Ma), long-term residence at 40-60 °C in the mid-Tertiary (50-10 Ma), and cooling to near-surface temperatures after 10 Ma, and thus support young incision of the westernmost Grand Canyon. A subset of AHe data, when interpreted alone (i.e. without 4He/3He or AFT data), are better predicted by t-T paths that cool to surface temperatures during the Laramide, consistent with an ;old; Grand Canyon. However, the combined AFT, AHe, and 4He

  12. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  13. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  14. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  15. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  16. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained from...

  17. Ma2 antibodies: an evaluation of commercially available detection methods.

    PubMed

    Johannis, Wibke; Renno, Joerg H; Wielckens, Klaus; Voltz, Raymond

    2011-01-01

    Ma2 antibodies belong to the onconeuronal antibodies which define a "definite" paraneoplastic neurological syndrome (PNS). Because of the clinical relevance, use of two separate methods (indirect immunofluorescence technique--IFT--and immunoblot) is advocated; however, with an increasing number of commercially available assay systems, usually only one assay is performed. We compared IFT and three commercially available immunoblots (ravo Diagnostika, Euroimmun, Milenia Biotec) on sera from 35 patients with clinically suspected PNS. 17 were Ma2 antibody associated as defined by consensus result (showing positive reactivity in 2 assays), 18 were Ma2 antibody negative controls. Sensitivity/specificity for single assays were for IFT 94%/94%, for ravo Diagnostika PNS blot 88%/100%, for Euroimmun Neuronal Antigens Profile blot 100%/89%, and for Milenia Biotec MTR blot 94%/100%. Our data confirm, although all tests performed well, a combination of 2 independent assays is still advisable for Ma2 antibody detection in order to achieve higher sensitivity and specificity rates.

  18. Cold Gas in Quenched Dwarf Galaxies using HI-MaNGA

    NASA Astrophysics Data System (ADS)

    Bonilla, Alaina

    2017-01-01

    MaNGA (Mapping of Nearby Galaxies at Apache Point Observatory) is a 6-year Sloan Digital Sky Survey fourth generation (SDSS-IV) project that will obtain integral field spectroscopy of a catalogue of 10,000 nearby galaxies. In this study, we explore the properties of the passive dwarf galaxy sample presented in Penny et al. 2016, making use of MaNGA IFU (Integral Field Unit) data to plot gas emission, stellar velocity, and flux maps. In addition, HI-MaNGA, a legacy radio-survey of MaNGA, collects single dish HI data retrieved from the GBT (Green Bank Telescope), which we use to study the the 21cm emission lines present in HI detections. Studying the HI content of passive dwarves will help us reveal the processes that are preventing star formation, such as possible AGN feedback. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from the Sloan Foundation to the Astrophysical Research Consortium.

  19. Diffusion welding of MA 6000 and a conventional nickel-base superalloy

    NASA Technical Reports Server (NTRS)

    Moore, T. J.; Glasgow, T. K.

    1985-01-01

    A feasibility study of diffusion welding the oxide dispersion strengthened (ODS) alloy MA 6000 to itself and to conventional Ni-base superalloy Udimet 700 was conducted. Butt joints between MA 6000 pieces and lap joints between Udimet 700 and the ODS alloy were produced by hot pressing for 1.25 hr at temperatures ranging from 1000 to 1200 C (1832-2192 F) in vacuum. Following pressing, all weldments were heat treated and machined into mechanical property test specimens. While three different combinations of recrystallized and unrecrystallized MA 6000 butt joints were produced, the unrecrystallized to unrecrystallized joint was most successful as determined by mechanical properties and microstructural examination. Failure to weld the recrystallized material probably related to a lack of adequate deformation at the weld interface. While recrystallized MA 6000 could be diffusion welded to Udimet 700 in places, complete welding over the entire lap joint was not achieved, again due to the lack of sufficient deformation at the faying surfaces. Several methods are proposed to promote the intimate contact necessary for diffusion welding MA 6000 to itself and to superalloys.

  20. On the Alignment and Focusing of the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS)

    NASA Technical Reports Server (NTRS)

    Champey, Patrick; Winebarger, Amy; Kobayashi, Ken; Savage, Sabrina; Cirtain, Jonathan; Cheimets, Peter; Hertz, Edward; Golub, Leon; Ramsey, Brian; McCracken, Jeff

    2016-01-01

    The Marshall Grazing Incidence X-ray Spectrometer (MaGIXS) is a NASA sounding rocket instrument that is designed to observe soft X-ray emissions from 24 - 6.0 A (0.5 - 2.0 keV energies) in the solar atmosphere. For the rst time, high-temperature, low-emission plasma will be observed directly with 5 arcsecond spatial resolution and 22 mA spectral resolution. The unique optical design consists of a Wolter - I telescope and a 3-optic grazing- incidence spectrometer. The spectrometer utilizes a nite conjugate mirror pair and a blazed planar, varied line spaced grating, which is directly printed on a silicon substrate using e-beam lithography. The grating design is being nalized and the grating will be fabricated by the Massachusetts Institute of Technology (MIT) and Izentis LLC. Marshall Space Flight Center (MSFC) is producing the nickel replicated telescope and spectrometer mirrors using the same facilities and techniques as those developed for the ART-XC and FOXSI mirrors. The Smithsonian Astrophysical Observatory (SAO) will mount and align the optical sub-assemblies based on previous experience with similar instruments, such as the Hinode X-Ray Telescope (XRT). The telescope and spectrometer assembly will be aligned in visible light through the implementation of a theodolite and reference mirrors, in addition to the centroid detector assembly (CDA) { a device designed to align the AXAF-I nested mirrors. Focusing of the telescope and spectrometer will be achieved using the X-ray source in the Stray Light Facility (SLF) at MSFC. We present results from an alignment sensitivity analysis performed on the on the system and we also discuss the method for aligning and focusing MaGIXS.

  1. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  2. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  3. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Risk sharing with regional MA organizations for... for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA regional plan offered...

  4. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  5. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  6. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  7. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  8. Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

    M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

  9. Safety in laboratories: Indian scenario.

    PubMed

    Mustafa, Ajaz; Farooq, A Jan; Qadri, Gj; S A, Tabish

    2008-07-01

    Health and safety in clinical laboratories is becoming an increasingly important subject as a result of emergence of highly infectious diseases such as Hepatitis and HIV. A cross sectional study was carried out to study the safety measures being adopted in clinical laboratories of India. Heads of laboratories of teaching hospitals of India were subjected to a standardized, pretested questionnaire. Response rate was 44.8%. only 60% of laboratories had person in-charge of safety in laboratory. Seventy three percent of laboratories had safety education program regarding hazards. In 91% of laboratories staff is using protective clothing while working in laboratories. Hazardous material regulations are followed in 78% of laboratories. Regular health check ups are carried among laboratory staff in 43.4% of laboratories.Safety manual is available in 56.5% of laboratories. 73.9% of laboratories are equipped with fire extinguishers. Fume cupboards are provided in 34.7% of laboratories and they are regularly checked in 87.5% of these laboratories. In 78.26% of laboratories suitable measures are taken to minimize formation of aerosols.In 95.6% of laboratories waste is disposed off as per bio-medical waste management handling rules. Laboratory of one private medical college was accredited with NABL and safety parameters were better in that laboratory. Installing safety engineered devices apparently contributes to significant decrease in injuries in laboratories; laboratory safety has to be a part of overall quality assurance programme in hospitals. Accreditation has to be made necessary for all laboratories.

  10. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  11. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  12. Explorer 1 60th Anniversary

    NASA Image and Video Library

    2018-01-31

    Michael Watkins, Director of NASA's Jet Propulsion Laboratory, left, Susan Finley, who began working at NASA's Jet Propulsion Laboratory in January 1958 as a "human computer", center, and Thomas Zurbuchen, Associate Administrator for NASA's Science Mission Directorate, right, pose for a picture with a replica of the Explorer 1 satellite during an event celebrating the 60th Anniversary of the Explorer 1 mission and the discovery of Earth's radiation belts, Wednesday, Jan. 31, 2018, at the National Academy of Sciences in Washington. The first U.S. satellite, Explorer 1, was launched from Cape Canaveral on January 31, 1958. The 30-pound satellite would yield a major scientific discovery, the Van Allen radiation belts circling our planet, and begin six decades of groundbreaking space science and human exploration. (NASA/Joel Kowsky)

  13. Southern portion of Taiwan photographed during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06437 (15-16 May 1963) --- The southern portion of the island of Taiwan (Formosa), Formosa Straight and the Pacific Ocean, looking northeast, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  14. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from MARAD's underwriting agent or MARAD. ...

  15. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  16. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  17. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  18. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  19. Tibet-Kashmir, looking northwest, photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06444 (15-16 May 1963) --- Tibet-Kashmir, looking northwest, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr. during his 22-orbit MA-9 spaceflight. Lake Ch'in-Tzu-Hu is at upper right, Lake Yen-K'o-Ling-Ts is at lower left center. The Korakaram Range is at upper center portion of the picture. Photo credit: NASA

  20. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Payments to MA organizations for graduate medical... Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time that...

  1. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Payments to MA organizations for graduate medical... Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time that...

  2. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  3. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  4. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  5. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  6. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  7. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond A, Form MA-308. 308.528 Section 308.528 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The...

  8. 46 CFR 308.529 - Surety Bond B, Form MA-309.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond B, Form MA-309. 308.529 Section 308.529 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309. An...

  9. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  10. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  11. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  12. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  13. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false How an MA organization must effectuate expedited..., Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an expedited request for service...

  14. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  15. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false How an MA organization must effectuate expedited..., Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an expedited request for service...

  16. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis.

    PubMed

    Mathew, R M; Vandenberghe, R; Garcia-Merino, A; Yamamoto, T; Landolfi, J C; Rosenfeld, M R; Rossi, J E; Thiessen, B; Dropcho, E J; Dalmau, J

    2007-03-20

    To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age < 50 years, 4) absence of other tumors, and 5) new testicular enlargement or risk factors for germ-cell tumors, mainly cryptorchidism or ultrasound evidence of testicular microcalcifications. All orchiectomy specimens showed intratubular-germ cell neoplasms unclassified type (IGCNU) and other abnormalities including microcalcifications, atrophy, fibrosis, inflammatory infiltrates, or hypospermatogenesis. Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy.

  17. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis

    PubMed Central

    Mathew, R.M.; Vandenberghe, R.; Garcia-Merino, A.; Yamamoto, T.; Landolfi, J.C.; Rosenfeld, M.R.; Rossi, J.E.; Thiessen, B.; Dropcho, E.J.; Dalmau, J.

    2007-01-01

    Objective: To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Methods: Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Results: Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age < 50 years, 4) absence of other tumors, and 5) new testicular enlargement or risk factors for germ-cell tumors, mainly cryptorchidism or ultrasound evidence of testicular microcalcifications. All orchiectomy specimens showed intratubular-germ cell neoplasms unclassified type (IGCNU) and other abnormalities including microcalcifications, atrophy, fibrosis, inflammatory infiltrates, or hypospermatogenesis. Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. Conclusions: In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy. PMID:17151337

  18. [The medical theory of Lee Je-ma and its character].

    PubMed

    Lee, Kyung-Lock

    2005-12-01

    Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  19. MERCURY-ATLAS (MA)-6 - ASTRONAUT GLENN - LT. O'HARA, DELORES (DEE)

    NASA Image and Video Library

    1962-03-09

    S62-00469 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury-Atlas 6 (MA-6) Earth-orbital space mission, confers with astronaut nurse Dolores B. O'Hara, R.N., during MA-6 prelaunch preparations. Photo credit: NASA

  20. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    NASA Astrophysics Data System (ADS)

    Weijmans, A.-M.; MaNGA Team

    2016-10-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  1. Formation of buckminsterfullerene (C60) in interstellar space

    PubMed Central

    Berné, Olivier; Tielens, A. G. G. M.

    2012-01-01

    Buckminsterfullerene (C60) was recently confirmed as the largest molecule identified in space. However, it remains unclear how and where this molecule is formed. It is generally believed that C60 is formed from the buildup of small carbonaceous compounds in the hot and dense envelopes of evolved stars. Analyzing infrared observations, obtained by Spitzer and Herschel, we found that C60 is efficiently formed in the tenuous and cold environment of an interstellar cloud illuminated by strong ultraviolet (UV) radiation fields. This implies that another formation pathway, efficient at low densities, must exist. Based on recent laboratory and theoretical studies, we argue that polycyclic aromatic hydrocarbons are converted into graphene, and subsequently C60, under UV irradiation from massive stars. This shows that alternative—top-down—routes are key to understanding the organic inventory in space. PMID:22198841

  2. Formation of buckminsterfullerene (C60) in interstellar space.

    PubMed

    Berné, Olivier; Tielens, A G G M

    2012-01-10

    Buckminsterfullerene (C(60)) was recently confirmed as the largest molecule identified in space. However, it remains unclear how and where this molecule is formed. It is generally believed that C(60) is formed from the buildup of small carbonaceous compounds in the hot and dense envelopes of evolved stars. Analyzing infrared observations, obtained by Spitzer and Herschel, we found that C(60) is efficiently formed in the tenuous and cold environment of an interstellar cloud illuminated by strong ultraviolet (UV) radiation fields. This implies that another formation pathway, efficient at low densities, must exist. Based on recent laboratory and theoretical studies, we argue that polycyclic aromatic hydrocarbons are converted into graphene, and subsequently C(60), under UV irradiation from massive stars. This shows that alternative--top-down--routes are key to understanding the organic inventory in space.

  3. Formation of buckminsterfullerene (C60) in interstellar space

    NASA Astrophysics Data System (ADS)

    Berné, Olivier; Tielens, Alexander G. G. M.

    2012-01-01

    Buckminsterfullerene (C60) was recently confirmed to be the largest molecule identified in space. However, it remains unclear how, and where this molecule is formed. It is generally believed that C60 is formed from the build up of small carbonaceous compounds, in the hot and dense envelopes of evolved stars. Analyzing infrared observations, obtained by Spitzer and Herschel, we found that C60 is efficiently formed in the tenuous and cold environment of an interstellar cloud illuminated by strong ultraviolet (UV) radiation fields. This implies that another formation pathway, efficient at low densities, must exist. Based on recent laboratory and theoretical studies, we argue that Polycyclic Aromatic Hydrocarbons are converted into graphene, and subsequently C60, under UV irradiation from massive stars. This shows that alternative - top-down - routes are key to understanding the organic inventory in space.

  4. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for beneficiaries enrolled in MA MSA... Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  5. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  6. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  7. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  8. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for beneficiaries enrolled in MA MSA... Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  9. Using superconducting undulator for enhanced imaging capabilities of MaRIE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yampolsky, Nikolai

    MaRIE x-ray free electron laser (FEL) is envisioned to deliver a burst of closely spaced in time pulses for enabling the capability of studying the dynamic processes in a sample. MaRIE capability can be largely enhanced using the superconducting undulator, which has the capability of doubling its period. This technology will allow reaching the photon energy as low as ~200-500 eV. As a result, the MaRIE facility will have a broader photon energy range enabling a larger variety of experiments. The soft x-ray capability is more likely to achieve the 3D imaging of dynamic processes in noncrystal materials than themore » hard x-ray capability alone.« less

  10. Moon/Mars Landing Commemorative Release: Gusev Crater and Ma'adim Vallis

    NASA Technical Reports Server (NTRS)

    1998-01-01

    , buried craters, and huge mesas near the mouth of Ma'adim Vallis--are composed of sediment that eroded out of the highlands to the south of Gusev Crater. In 1995, the Exobiology Program Office at NASA Headquarters produced a report, An Exobiological Strategy for Mars Exploration (NASA SP-530), that included Gusev Crater as a possible priority site for future Mars exploration because it might once have been a lake.

    At 12:17 a.m. (PDT) on April 24, 1998-- during Mars Global Surveyor's 259th orbit--MOC obtained the high resolution image of Gusev Crater and Ma'adim Vallis shown above, in part to test some of the proposed hypotheses. The raw image has a scale of 7.3 meters (24 feet) per pixel. At this scale, there are no obvious shorelines that would indicate the past presence of a lake in either Ma'adim Vallis or Gusev Crater. There are several alternative explanations for this absence, including:

    It is possible that any lake in Gusev occurred so long ago that erosion by wind and hillslope processes have long since removed such features.

    It is possible that 7.3 meters per pixel is insufficient to identify key diagnostic lake features.

    It is possible that a lake once existed, but that shore- and near-shore processes as they occur in terrestrial lake environments did not occur on Mars.

    It is possible no lake ever existed.

    When Mars Global Surveyor achieves its Mapping Orbit in March 1999, MOC will have the ability to obtain pictures with resolutions around 1.5 meters (5 feet) per pixel. Sometime during the mapping mission, it may be possible to image Gusev Crater again to look for potential lake features and possible future landing sites.

    Malin Space Science Systems and the California Institute of Technology built the MOC using spare hardware from the Mars Observer mission. MSSS operates the camera from its facilities in San Diego, CA. The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor

  11. Astronaut Kenneth Reightler, STS-60 pilot, during egress training

    NASA Image and Video Library

    1993-12-10

    Astronaut Kenneth S. Reightler, pilot for the STS-60 mission, prepares to simulate egress from a troubled Space Shuttle using Crew Escape System (CES) pole. The action came during emergency egress training in JSC's Shuttle mockup and integration laboratory.

  12. Proposal MaMBA - Moon and Mars Base Analog

    NASA Astrophysics Data System (ADS)

    Heinicke, Christiane; Foing, Bernard

    2017-04-01

    Despite impressive progress in robotic exploration of celestial bodies, robots are believed to never reach the effectiveness and efficiency of a trained human. Consequently, ESA proposes to build an international Moon Village in roughly 15 years and NASA plans for the first manned mission to Mars shortly after. One of the challenges still remaining is the need for a shelter, a habitat which allows human spacefarers to safely live and work on the surface of a celestial body. Although various prototype habitats have been built and inhabited during the last decade, they typically share two fundamental flaws: First, they usually consist of a single space, which may become uninhabitable after depressurization due to just one single catastrophic event. Second, none of the habitats provides shielding against radiation, one of the major health concerns for spacefaring crews. Project MaMBA will address these two problems at the root and build an underground habitat comprised of five connected, but independent modules. The habitat will serve for testing technologies like life support, power systems, and interplanetary communication. Special attention will be given to the development of the geoscience laboratory module. In addition to the technological aspects, the envisioned habitat will serve as a unique test ground for studies on the effects of underground habitation on a crew.

  13. MERCURY-ATLAS (MA)-9 - EARTH-SKY VIEW - INDIA - EARTH RESOURCES (ER)

    NASA Image and Video Library

    1963-05-16

    S63-06435 (15-16 May 1963) --- Part of the Ganges delta near Calcutta, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  14. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  15. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  16. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  17. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  18. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  19. MaMBA - a functional Moon and Mars Base Analog

    NASA Astrophysics Data System (ADS)

    Heinicke, C.; Foing, B.

    2017-09-01

    Despite impressive progress in robotic exploration of celestial bodies, robots are believed to never reach the effectiveness and efficiency of a trained human. Consequently, ESA proposes to build an international Moon Village in roughly 15 years and NASA plans for the first manned mission to Mars shortly after. One of the challenges still remaining is the need for a shelter, a habitat which allows human spacefarers to safely live and work on the surface of a celestial body. Although a number of prototype habitats has been built during the last decades and inhabited for various durations (e.g. MDRS, FMARS, HI-SEAS, M.A.R.S.), these habitats are typically equipped for studies on human factors and would not function in an extraterrestrial environment. Project MaMBA (Moon and Mars Base Analog) aims to build the first functional habitat based on the lessons learned from intermediate and long duration missions at the mentioned habitats. The habitat will serve for testing technologies like life support, power systems, and interplanetary communi­cation. Special attention will be given to the develop­ment of the geoscience laboratory module. Crews will live and work inside the habitat to ensure its functionality.

  20. 77 FR 19573 - Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...-AA00 Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS... zone on the navigable waters of the Boston Inner Harbor in the vicinity of Anthony's Pier 4, Boston, MA... Boston Inner Harbor in the vicinity of Anthony's Pier 4, Boston, MA. The Captain of the Port (COTP...

  1. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  2. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  3. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  4. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  5. Ma'adim Vallis From the Top

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is a still from an animation showing the geography of Ma'adim Vallis, a valley or channel that enters Gusev Crater. The view of the crater is from the northwest, which is not the direction from which Spirit approached the crater as it landed.

  6. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

  7. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  8. 75 FR 34929 - Safety Zones: Neptune Deep Water Port, Atlantic Ocean, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zones: Neptune Deep Water Port, Atlantic Ocean, Boston, MA AGENCY: Coast Guard, DHS. ACTION..., Boston, MA; Final Rule (USCG-2009-0589), to protect vessels from the hazard posed by the presence of the... read as follows: Sec. 165.T01-0542 Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA. (a...

  9. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  10. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  11. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

  12. MaGnET: Malaria Genome Exploration Tool.

    PubMed

    Sharman, Joanna L; Gerloff, Dietlind L

    2013-09-15

    The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

  13. [How do hospital clinical laboratories and laboratory testing companies cooperate and build reciprocal relations?].

    PubMed

    Kawano, Seiji

    2014-12-01

    As the 2nd Joint Symposium of the Japanese Society of Laboratory Medicine and the Japanese Association of Laboratory Pathologists, the symposium on clinical test out-sourcing and branch laboratories was held at the 60th General Meeting of the Japanese Society of Laboratory Medicine on November 2nd, 2013 in Kobe. For the symposium, we conducted a questionnaire survey on the usage of clinical test out-sourcing and the introduction of branch laboratories to clinical laboratories of Japanese university hospitals, both private and public, between July 25th and August 20th, 2013. Seventy-two hospitals responded to the questionnaire survey, consisting of 41 public medical school hospitals and 31 private ones. According to the survey, the selection of each clinical test for out-sourcing was mainly determined by the capacities of hospital clinical laboratories and their equipment, as well as the profitability of each test. The main concerns of clinical laboratory members of university hospitals involved the continuity of measurement principles, traceability, and standardization of reference values for each test. They strongly requested the interchangeability and computerization of test data between laboratory testing companies. A branch laboratory was introduced to six hospitals, all of which were private medical college hospitals, out of 72 university hospitals, and eight of the other hospitals were open to its introduction. The merits and demerits of introducing a branch laboratory were also discussed. (Review).

  14. Visual simulation through an aspheric aberration-correcting intraocular lens in subjects with different corneal profiles using adaptive optics.

    PubMed

    Ruiz-Alcocer, Javier; Madrid-Costa, David; García-Lázaro, Santiago; Albarrán-Diego, César; Ferrer-Blasco, Teresa

    2013-07-01

    The aim of this study was to analyse the visual quality of the AcrySof IQ SN60WF(®) intraocular lens (IOL) when combined with different corneal profiles. Ten eyes of 10 participants with no prior history of refractive or cataract surgery were evaluated. An adaptive optics visual simulator was used to simulate the wavefront aberration pattern of an aspheric aberration-correcting IOL (AcrySof IQ SN60WF(®)). Normal corneas (group A), low and high myopic corneal ablations (groups B and C, respectively) and low and high hyperopic corneal ablations (groups D and E, respectively) were also simulated. Monocular distance visual acuities at 100, 50 and 10 per cent of contrast were measured. At 100, 50 and 10 per cent contrast, no differences were found between groups A and B (p > 0.06 for all contrasts). Group A obtained better values than groups C, D and E for all contrasts (p = 0.031, p = 0.038, p = 0.032 at 100, 50 and 10 per cent of contrast, respectively). At the same time, group B obtained better values than groups C, D and E (p = 0.041, p = 0.042, p = 0.036 at 100, 50 and 10 per cent of contrast, respectively). Within the five groups, the worst results were always obtained for group E (p = 0.017, p = 0.021 and p = 0.025 at 100, 50 and 10 per cent of contrast, respectively). The results suggest that the aspheric aberration-correcting IOL studied provides comparable results, when it is combined with normal corneas and with corneas with simulated low myopic ablations. When negative amounts of residual spherical aberration after cataract surgery are expected to be achieved, IOLs with more positive spherical aberration should be considered. © 2013 The Authors. Clinical and Experimental Optometry © 2013 Optometrists Association Australia.

  15. East-looking view across Atlantic waters during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06434 (15-16 May 1963) --- East looking view across Atlantic waters toward Africa, showing Mauritania and Spanish Sahara photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  16. New Regimes of Implosions of Larger Sized Wire Arrays With and Without Modified Central Plane at 1.5-1.7 MA Zebra

    NASA Astrophysics Data System (ADS)

    Safronova, A. S.; Kantsyrev, V. L.; Esaulov, A. A.; Weller, M. E.; Shrestha, I.; Shlyaptseva, V. V.; Stafford, A.; Keim, S. F.; Petkov, E. E.; Lorance, M.; Chuvatin, A. S.; Coverdale, C. A.; Jones, B.

    2013-10-01

    The recent experiments at 1.5-1.7 MA on Zebra at UNR with larger sized planar wires arrays (compared to the wire loads at 1 MA current) have demonstrated higher linear radiation yield and electron temperatures as well as advantages of better diagnostics access to observable plasma regions. Such multi-planar wire arrays had two outer wire planes from mid-Z material to create a global magnetic field (gmf) and mid-Z plasma flow between them. Also, they included a modified central plane with a few Al wires at the edges to influence gmf and to create Al plasma flow in the perpendicular direction. The stationary shock waves which existed over tens of ns on shadow images and the early x-ray emissions before the PCD peak on time-gated spectra were observed. The most recent experiments with similar loads but without the central wires demonstrated a very different regime of implosion with asymmetrical jets and no precursor formation. This work was supported by NNSA under DOE Cooperative Agreement DE-NA0001984 and in part by DE-FC52-06NA27616. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  17. Anti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple's disease.

    PubMed

    Castle, James; Sakonju, Ai; Dalmau, Josep; Newman-Toker, David E

    2006-10-01

    A 39-year-old man presented with a history of several months of progressive personality changes, social withdrawal, bradykinesia, mutism, dysphagia, worsening gait, and difficulty with daily living activities. Examination revealed an atypical parkinsonian appearance with incomplete supranuclear ophthalmoplegia and an unusual oculomotor disorder characterized by both low-amplitude, intermittent opsoclonus, and slow, nystagmoid intrusions. Routine laboratory testing, autoimmune and infectious serologies, brain MRI, lumbar puncture, electroencephalogram, whole-body CT scan, paraneoplastic serologies, small bowel biopsy, 18F-fluorodeoxyglucose positron emission tomography CT scan, brain biopsy, and testicular ultrasound. Anti-Ma2 paraneoplastic encephalitis in association with metastatic testicular cancer; initially misdiagnosed as CNS Whipple's disease. Corticosteroids, intravenous immunoglobulins, orchiectomy, muscle relaxants, mycophenolate mofetil, plasmapheresis, and bleomycin, etoposide and platinum chemotherapy.

  18. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  19. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  20. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  1. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  2. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  3. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  4. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  5. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  6. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  7. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  8. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Source of payment and effect of MA plan election on... Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA...

  9. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Source of payment and effect of MA plan election on... Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA...

  10. Anti-ma2 paraneoplastic encephalitis in association with recurrent cervical cancer.

    PubMed

    Ney, Douglas E; Messersmith, Wells; Behbakht, Kian

    2014-07-01

    Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes. This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy.

  11. A regional 17-18 MA thermal event in Southwestern Arizona

    NASA Technical Reports Server (NTRS)

    Brooks, W. E.

    1985-01-01

    A regional thermal event in southwestern Arizona 17 to 18 Ma ago is suggested by discordances between fission track (FT) and K-Ar dates in Tertiary volcanic and sedimentary rocks, by the abundance of primary hydrothermal orthoclase in quenched volcanic rocks, and by the concentration of Mn, Ba, Cu, Ag, and Au deposits near detachment faults. A high condont alteration index (CAI) of 3 to 7 is found in Paleozoic rocks of southwestern Arizona. The high CAI may have been caused by this mid-Tertiary thermal event. Resetting of temperature-sensitive TF dates (2) 17 to 18 Ma with respect to K-Ar dates of 24 and 20 Ma has occurred in upper plate volcanic rocks at the Harcuvar and Picacho Peak detachments. Discordances between FT and K-Ar dates are most pronounced at detachment faults. However, on a regional scale Ft dates from volcanic and sedimentary rocks approach 17 to 18 Ma event in areas away from known detachment faults. Effects of detachment faulting on the K-Ar system suggest that dates of correlative rocks will be younger as the detachment fault is approached.

  12. Evaluation overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project.

    PubMed

    Davison, Kirsten K; Falbe, Jennifer; Taveras, Elsie M; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E; Franckle, Rebecca L; Ganter, Claudia; Baidal, Jennifer Woo; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

    2015-02-01

    The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2-12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15-40% of children consumed no vegetables on the previous day, 25-75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50-75% had a television in the room where they slept, and 50-80% obtained insufficient sleep. There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control.

  13. 60. FIFTH FLOOR PLAN, SECTIONS AND DETAILS OF 1937 ADDITION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. FIFTH FLOOR PLAN, SECTIONS AND DETAILS OF 1937 ADDITION TO BUILDINGS No. 2 and 4, DATED JUNE 24, 1937: SCHMIDT, GARDEN AND ERICKSON, ARCHITECTS - Underwriters' Laboratories, 207-231 East Ohio Street, Chicago, Cook County, IL

  14. 78 FR 2708 - Massachusetts Disaster # MA-00050

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13431 and 13432] Massachusetts Disaster MA-00050 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major [[Page 2709

  15. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  16. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  17. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  18. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  19. Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

    NASA Astrophysics Data System (ADS)

    Zhang, Chuan; Schempp, Alwin

    2009-10-01

    A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

  20. Recurrent Early Cretaceous, Indo-Madagascar (89-86 Ma) and Deccan (66 Ma) alkaline magmatism in the Sarnu-Dandali complex, Rajasthan: 40Ar/39Ar age evidence and geodynamic significance

    NASA Astrophysics Data System (ADS)

    Sheth, Hetu; Pande, Kanchan; Vijayan, Anjali; Sharma, Kamal Kant; Cucciniello, Ciro

    2017-07-01

    The Sarnu-Dandali alkaline complex in Rajasthan, northwestern India, is considered to represent early, pre-flood basalt magmatism in the Deccan Traps province, based on a single 40Ar/39Ar age of 68.57 Ma. Rhyolites found in the complex are considered to be 750 Ma Malani basement. Our new 40Ar/39Ar ages of 88.9-86.8 Ma (for syenites, nephelinite, phonolite and rhyolite) and 66.3 ± 0.4 Ma (2σ, melanephelinite) provide clear evidence that whereas the complex has Deccan-age (66 Ma) components, it is dominantly an older (by 20 million years) alkaline complex, with rhyolites included. Basalt is also known to underlie the Early Cretaceous Sarnu Sandstone. Sarnu-Dandali is thus a periodically rejuvenated alkaline igneous centre, active twice in the Late Cretaceous and also earlier. Many such centres with recurrent continental alkaline magmatism (sometimes over hundreds of millions of years) are known worldwide. The 88.9-86.8 Ma 40Ar/39Ar ages for Sarnu-Dandali rocks fully overlap with those for the Indo-Madagascar flood basalt province formed during continental breakup between India (plus Seychelles) and Madagascar. Recent 40Ar/39Ar work on the Mundwara alkaline complex in Rajasthan, 120 km southeast of Sarnu-Dandali, has also shown polychronous emplacement (over ≥ 45 million years), and 84-80 Ma ages obtained from Mundwara also arguably represent post-breakup stages of the Indo-Madagascar flood basalt volcanism. Remnants of the Indo-Madagascar province are known from several localities in southern India but hitherto unknown from northwestern India 2000 km away. Additional equivalents buried under the vast Deccan Traps are highly likely.

  1. External quality assurance performance of clinical research laboratories in sub-saharan Africa.

    PubMed

    Amukele, Timothy K; Michael, Kurt; Hanes, Mary; Miller, Robert E; Jackson, J Brooks

    2012-11-01

    Patient Safety Monitoring in International Laboratories (JHU-SMILE) is a resource at Johns Hopkins University that supports and monitors laboratories in National Institutes of Health-funded international clinical trials. To determine the impact of the JHU-SMILE quality assurance scheme in sub-Saharan African laboratories, we reviewed 40 to 60 months of external quality assurance (EQA) results of the College of American Pathologists (CAP) in these laboratories. We reviewed the performance of 8 analytes: albumin, alanine aminotransferase, creatinine, sodium, WBC, hemoglobin, hematocrit, and the human immunodeficiency virus antibody rapid test. Over the 40- to 60-month observation period, the sub-Saharan laboratories had a 1.63% failure rate, which was 40% lower than the 2011 CAP-wide rate of 2.8%. Seventy-six percent of the observed EQA failures occurred in 4 of the 21 laboratories. These results demonstrate that a system of remote monitoring, feedback, and audits can support quality in low-resource settings, even in places without strong regulatory support for laboratory quality.

  2. Semiconductor laser joint study program with Rome Laboratory

    NASA Astrophysics Data System (ADS)

    Schaff, William J.; Okeefe, Sean S.; Eastman, Lester F.

    1994-09-01

    A program to jointly study vertical-cavity surface emitting lasers (VCSEL) for high speed vertical optical interconnects (VOI) has been conducted under an ES&E between Rome Laboratory and Cornell University. Lasers were designed, grown, and fabricated at Cornell University. A VCSEL measurement laboratory has been designed, built, and utilized at Rome Laboratory. High quality VCSEL material was grown and characterized by fabricating conventional lateral cavity lasers that emitted at the design wavelength of 1.04 microns. The VCSEL's emit at 1.06 microns. Threshold currents of 16 mA at 4.8 volts were obtained for 30 microns diameter devices. Output powers of 5 mW were measured. This is 500 times higher power than from the light emitting diodes employed previously for vertical optical interconnects. A new form of compositional grading using a cosinusoidal function has been developed and is very successful for reducing diode series resistance for high speed interconnection applications. A flip-chip diamond package compatible with high speed operation of 16 VCSEL elements has been designed and characterized. A flip-chip device binding effort at Rome Laboratory was also designed and initiated. This report presents details of the one-year effort, including process recipes and results.

  3. 33 CFR 100.113 - Provincetown Harbor Swim for Life, Provincetown, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Provincetown Harbor Swim for Life, Provincetown, MA. 100.113 Section 100.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... for Life, Provincetown, MA. (a) Regulated Area. All waters of Provincetown Harbor within 200 feet of...

  4. 33 CFR 100.116 - Swim Buzzards Bay Day, New Bedford, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Swim Buzzards Bay Day, New Bedford, MA. 100.116 Section 100.116 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., New Bedford, MA. (a) Regulated Area. All waters of the Acushnet River, within 200 feet of...

  5. 33 CFR 100.116 - Swim Buzzards Bay Day, New Bedford, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Swim Buzzards Bay Day, New Bedford, MA. 100.116 Section 100.116 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., New Bedford, MA. (a) Regulated Area. All waters of the Acushnet River, within 200 feet of...

  6. Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor.

    PubMed

    Roelofs, Maarke J E; van den Berg, Martin; Bovee, Toine F H; Piersma, Aldert H; van Duursen, Majorie B M

    2015-03-02

    Although much information on the endocrine activity of bisphenol A (BPA) is available, a proper human hazard assessment of analogues that are believed to have a less harmful toxicity profile is lacking. Here the possible effects of BPA, bisphenol F (BPF), bisphenol S (BPS), as well as the brominated structural analogue and widely used flame retardant tetrabromobisphenol A (TBBPA) on human glucocorticoid and androgen receptor (GR and AR) activation were assessed. BPA, BPF, and TBBPA showed clear GR and AR antagonism with IC50 values of 67 μM, 60 μM, and 22 nM for GR, and 39 μM, 20 μM, and 982 nM for AR, respectively, whereas BPS did not affect receptor activity. In addition, murine MA-10 Leydig cells exposed to the bisphenol analogues were assessed for changes in secreted steroid hormone levels. Testicular steroidogenesis was altered by all bisphenol analogues tested. TBBPA effects were more directed towards the male end products and induced testosterone synthesis, while BPF and BPS predominantly increased the levels of progestagens that are formed in the beginning of the steroidogenic pathway. The MA-10 Leydig cell assay shows added value over the widely used H295R steroidogenesis assay because of its fetal-like characteristics and specificity for the physiologically more relevant testicular Δ4 steroidogenic pathway. Therefore, adding an in vitro assay covering fetal testicular steroidogenesis, such as the MA-10 cell line, to the panel of tests used to screen potential endocrine disruptors, is highly recommendable. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  8. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  9. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  10. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  11. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  12. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  13. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  14. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  15. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  16. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  17. Evaluation Overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) Project

    PubMed Central

    Falbe, Jennifer; Taveras, Elsie M.; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E.; Franckle, Rebecca L.; Ganter, Claudia; Woo Baidal, Jennifer; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

    2015-01-01

    Abstract Background: The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2–12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. Methods/Design: The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. Results: At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15–40% of children consumed no vegetables on the previous day, 25–75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50–75% had a television in the room where they slept, and 50–80% obtained insufficient sleep. Conclusions: There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control. PMID:25575095

  18. RadNet Air Data From Boston, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Boston, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  19. RadNet Air Data From Worcester, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Worcester, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  20. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody.

    PubMed

    Barnett, M; Prosser, J; Sutton, I; Halmagyi, G M; Davies, L; Harper, C; Dalmau, J

    2001-02-01

    A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

  1. Onset of the Sveconorwegian orogeny: 1220-1130 Ma bimodal magmatism, sedimentation and granulite-facies metamorphism

    NASA Astrophysics Data System (ADS)

    Bingen, Bernard; Viola, Giulio; Engvik, Ane K.; Solli, Arne

    2013-04-01

    The Grenville orogen of Laurentia and the Sveconorwegian orogen of Baltica are generally interpreted as long-lived, hot, collisional orogens resulting from collision of a possibly joined Laurentia-Baltica margin with another major plate, possibly Amazonia. Here we report new mapping, petrologic and SIMS U-Pb geochronological data from S Norway, to address the pre- to early-Sveconorwegian evolution between 1220 and 1130 Ma. The Sveconorwegian belt includes from west to east the Telemarkia terrane characterized by 1520-1480 Ma magmatism and the Idefjorden terrane characterized by Gothian active margin 1660-1520 Ma magmatism. The Idefjorden terrane is thrusted eastwards onto the parauthochthonous Eastern Segment. The Kongsberg and Bamble are two small terranes between the Idefjorden and Telemarkia terranes. They have a strong N-S and NE-SW structural grain, respectively, and are thrust westwards on top of the Telemarkia terrane. Basement metavolcanic and metaplutonic rocks in the Kongsberg terrane range from c. 1534 to 1500 Ma (5 new samples) and in Bamble from c. 1572 to 1460 Ma, overlapping with both the Telemarkia and Idefjorden terranes. New and published data show the following: (1) In Telemark, a c. 1200 Ma granitoid from the Flåvatn complex and a c. 1195 Ma granite sheet in the bimodal Nissedal supracrustals demonstrate that 1220-1180 Ma comparatively juvenile magmatism is the dominant rock type over much of southern part of Telemark. (2) A rhyolite dated at 1155 Ma complement available data showing low grade bimodal mafic-felsic volcanism interlayered with immature clastic sediments in central Telemark between 1169 and 1145 Ma (the ex-Bandak group). These supracrustals are intruded by c. 1153-1144 Ma A-type granite plutons. (3) Ten samples of foliated commonly porphyritic ganitoid and one granite dyke in gabbro collected in Kongsberg and along the Kongsberg-Telemark boundary demonstrate that c. 1171-1147 Ma bimodal plutonism occurred in Kongsberg. This

  2. High-resolution reconstructions of Pacific-North America plate motion: 20 Ma to present

    NASA Astrophysics Data System (ADS)

    DeMets, C.; Merkouriev, S.

    2016-11-01

    We present new rotations that describe the relative positions and velocities of the Pacific and North America plates at 22 times during the past 19.7 Myr, offering ≈1-Myr temporal resolution for studies of the geotectonic evolution of western North America and other plate boundary locations. Derived from ≈18 000 magnetic reversal, fracture zone and transform fault identifications from the Pacific-Antarctic-Nubia-North America plate circuit and the velocities of 935 GPS sites on the Pacific and North America plates, the new rotations and GPS-derived angular velocity indicate that the rate of motion between the two plates increased by ≈70 per cent from 19.7 to 9±1 Ma, but changed by less than 2 per cent since 8 Ma and even less since 4.2 Ma. The rotations further suggest that the relative plate direction has rotated clockwise for most of the past 20 Myr, with a possible hiatus from 9 to 5 Ma. This conflicts with previously reported evidence for a significant clockwise change in the plate direction at ≈8-6 Ma. Our new rotations indicate that Pacific plate motion became obliquely convergent with respect to the San Andreas Fault of central California at 5.2-4.2 Ma, in agreement with geological evidence for a Pliocene onset of folding and faulting in central California. Our reconstruction of the northern Gulf of California at 6.3 Ma differs by only 15-30 km from structurally derived reconstructions after including 3-4 km Myr-1 of geodetically measured slip between the Baja California Peninsula and Pacific plate. This implies an approximate 15-30 km upper bound for plate non-rigidity integrated around the global circuit at 6.3 Ma. A much larger 200±54 km discrepancy between our reconstruction of the northern Gulf of California at 12 Ma and that estimated from structural and marine geophysical observations suggests that faults in northwestern Mexico or possibly west of the Baja California Peninsula accommodated large amounts of obliquely divergent dextral shear

  3. Are laboratory tests always needed? Frequency and causes of laboratory overuse in a hospital setting.

    PubMed

    Cadamuro, Janne; Gaksch, Martin; Wiedemann, Helmut; Lippi, Giuseppe; von Meyer, Alexander; Pertersmann, Astrid; Auer, Simon; Mrazek, Cornelia; Kipman, Ulrike; Felder, Thomas K; Oberkofler, Hannes; Haschke-Becher, Elisabeth

    2018-04-01

    Inappropriate utilization of laboratory resources is an increasing concern especially in high-throughput facilities. Until now, no reliable information has been published addressing to which extent laboratory results are actually used for clinical decision-making. Therefore, we aimed to close this gap using a novel retrospective approach including a survey of clinicians and nurses. We retrospectively evaluated the number of re-orders for potassium (K), lactate dehydrogenase (LD), aspartate-aminotransferase (AST), activated partial thromboplastin-time (APTT) and prothrombin-time/INR (PT/INR), after the initial order had to be cancelled due to preanalytical non-conformities. We analyzed subgroups regarding time to re-order, ward and sample priority (urgent vs. routine). Subsequently, we surveyed clinicians and nurses, asking for their estimate of the amount of failed re-orders as well as for possible reasons. From initially cancelled tests, only ~20% of K, LD, AST and ~30% of APTT and PT/INR tests were re-ordered within 24 h. 70% of the investigated clinical chemistry and 60% of coagulation tests were re-ordered one week after cancellation or not at all. Survey participants quite accurately estimated these numbers. Routine laboratory panels, short stay of out-patients, obsolete test results and avoiding additional phlebotomies were the main reasons for not re-ordering cancelled tests. Overall, 60-70% of test results in the investigated assays ordered in a high throughput laboratory are potentially inappropriate or of doubtful clinically importance. Although clinicians and nurses are aware of this situation, it is the duty of laboratory specialists to overcome overutilization in close collaboration with all involved healthcare workers. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  4. Stormwater Pollution Prevention Plan - TA-60 Material Recycling Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sandoval, Leonard Frank

    This Storm Water Pollution Prevention Plan (SWPPP) was developed in accordance with the provisions of the Clean Water Act (33 U.S.C. §§1251 et seq., as amended), and the Multi-Sector General Permit for Storm Water Discharges Associated with Industrial Activity (U.S. EPA, June 2015) issued by the U.S. Environmental Protection Agency (EPA) for the National Pollutant Discharge Elimination System (NPDES) and using the industry specific permit requirements for Sector P-Land Transportation and Warehousing as a guide. This SWPPP applies to discharges of stormwater from the operational areas of the TA- 60 Material Recycling Facility at Los Alamos National Laboratory. Los Alamosmore » National Laboratory (also referred to as LANL or the “Laboratory”) is owned by the Department of Energy (DOE), and is operated by Los Alamos National Security, LLC (LANS). Throughout this document, the term “facility” refers to the TA-60 Material Recycling Facility. The current permit expires at midnight on June 4, 2020.« less

  5. Predicting Sediment Thickness on Vanished Ocean Crust Since 200 Ma

    NASA Astrophysics Data System (ADS)

    Dutkiewicz, A.; Müller, R. D.; Wang, X.; O'Callaghan, S.; Cannon, J.; Wright, N. M.

    2017-12-01

    Tracing sedimentation through time on existing and vanished seafloor is imperative for constraining long-term eustasy and for calculating volumes of subducted deep-sea sediments that contribute to global geochemical cycles. We present regression algorithms that incorporate the age of the ocean crust and the mean distance to the nearest passive margin to predict sediment thicknesses and long-term decompacted sedimentation rates since 200 Ma. The mean sediment thickness decreases from ˜220 m at 200 Ma to a minimum of ˜140 m at 130 Ma, reflecting the replacement of old Panthalassic ocean floor with young sediment-poor mid-ocean ridges, followed by an increase to ˜365 m at present-day. This increase reflects the accumulation of sediments on ageing abyssal plains proximal to passive margins, coupled with a decrease in the mean distance of any parcel of ocean crust to the nearest passive margin by over 700 km, and a doubling of the total passive margin length at present-day. Mean long-term sedimentation rates increase from ˜0.5 cm/ky at 160 Ma to over 0.8 cm/ky today, caused by enhanced terrigenous sediment influx along lengthened passive margins, superimposed by the onset of ocean-wide carbonate sedimentation. Our predictive algorithms, coupled to a plate tectonic model, provide a framework for constraining the seafloor sediment-driven eustatic sea-level component, which has grown from ˜80 to 210 m since 120 Ma. This implies a long-term sea-level rise component of 130 m, partly counteracting the contemporaneous increase in ocean basin depth due to progressive crustal ageing.

  6. Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

    NASA Astrophysics Data System (ADS)

    De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

    2017-07-01

    The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

  7. MaGnET: Malaria Genome Exploration Tool

    PubMed Central

    Sharman, Joanna L.; Gerloff, Dietlind L.

    2013-01-01

    Summary: The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive ‘exploration-style’ visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein–protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Availability and Implementation: Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org Contact: joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23894142

  8. Anti-Ma2 Paraneoplastic Encephalitis in Association with Recurrent Cervical Cancer

    PubMed Central

    Messersmith, Wells; Behbakht, Kian

    2014-01-01

    Background Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. Case Report We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes. Conclusions This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy. PMID:25045381

  9. Paleomagnetism of the 1210 Ma Gnowangerup-Fraser dyke swarm, Western Australia

    NASA Astrophysics Data System (ADS)

    Pisarevsky, S. A.; Li, Z. X.; Wingate, M. T. D.; Tohver, E.

    2012-04-01

    The Gnowangerup-Fraser mafic dyke swarm is part of the Marnda Moorn LIP and subparallel to the southern and southeastern margins of the Yilgarn Craton. Some dykes become progressively recrystallized towards the craton margin and others are strongly deformed within the orogen, implying that at least some dykes were emplaced prior to the youngest deformation in the Albany-Fraser Orogen. Five dykes have previously yielded U-Pb ages between 1203 and 1218 Ma, and the primary nature of the magnetic directions in a 1212 Ma Fraser dyke is supported by a positive baked-contact test. We collected paleomagnetism samples from 19 dykes, along the Phillips and Fitzgerald Rivers, and near Ravensthorpe. AF demagnetisation revealed a stable bipolar remanence in 13 dykes. The mean paleomagnetic pole is almost identical to the VGP of the 1212 Ma Fraser dyke. The combined robust paleopole places the West Australian Craton in a near-polar position at 1210 Ma. Comparison with coeval Laurentian paleopoles indicates that Laurentia and Australia were widely separated at that time.

  10. MaMiCo: Software design for parallel molecular-continuum flow simulations

    NASA Astrophysics Data System (ADS)

    Neumann, Philipp; Flohr, Hanno; Arora, Rahul; Jarmatz, Piet; Tchipev, Nikola; Bungartz, Hans-Joachim

    2016-03-01

    The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling the spatially adaptive Lattice Boltzmann framework waLBerla with four molecular dynamics (MD) codes: the light-weight Lennard-Jones-based implementation SimpleMD, the node-level optimized software ls1 mardyn, and the community codes ESPResSo and LAMMPS. We detail interface implementations to connect each solver with MaMiCo. The coupling for each waLBerla-MD setup is validated in three-dimensional channel flow simulations which are solved by means of a state-based coupling method. We provide sequential and strong scaling measurements for the four molecular-continuum simulations. The overhead of MaMiCo is found to come at 10%-20% of the total (MD) runtime. The measurements further show that scalability of the hybrid simulations is reached on up to 500 Intel SandyBridge, and more than 1000 AMD Bulldozer compute cores.

  11. Changing the Safety and Mission Assurance (S and MA) Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W.; Safie, Fayssal M.

    2010-01-01

    This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

  12. Paleomagnetic evidence for rapid vertical-axis rotation in the Peruvian Cordillera ca. 8 Ma

    NASA Astrophysics Data System (ADS)

    Rousse, Sonia; Gilder, Stuart; Farber, Daniel; McNulty, Brendan; Torres, Victor R.

    2002-01-01

    Paleomagnetic results from 31 Neogene sites in the Peruvian Andes yield primary magnetizations, as demonstrated by positive fold and reversal tests. Strata dated as 18 9 Ma record a significant counterclockwise rotation (-11° ± 5°), whereas unconformably overlying younger strata (7 6 Ma) are not rotated. The age of rotation thus is between 9 and 7 Ma, a period that coincides with the widespread Quechua 2 deformation phase. Moreover, eight independent studies on 107 9 Ma rocks from Peru between 9°S and 15°S reveal similar and significant rotations (-15° ± 6°). This suggests that the region rotated during a 2 m.y. period of deformation ca. 8 Ma, when the Andes underwent rapid uplift and important deformation commenced in the Subandean zone.

  13. LIFTOFF - MERCURY-ATLAS (MA)-9 - CAPE

    NASA Image and Video Library

    1963-01-01

    S63-07603 (15 May 1963) --- This is the launch of Mercury-Atlas 9 (MA-9) on May 15, 1963, at 8:04 a.m. (EST) carrying astronaut L. Gordon Cooper Jr., pilot. Astronaut Cooper made 22 orbits in 34 hours and 19 minutes, in the spacecraft designated the ?Faith 7". Photo credit: NASA

  14. Tactical Target Identification (TTI) Laboratory Simulation. Volume I.

    DTIC Science & Technology

    1980-03-01

    hi r 4> 5! hi - L 0 his0OG 2 ww -" S. - iii m1 tao -J-W - C;ao.h woo -4- ma 49 WKS ’-&#60-. S w0’ ii- 0 I-) 00-d > 01 t~o- W ZE S acuI w C o~ 0E0’owj...u 1 m I oL K 0 L - - - - ( o -- Ua4-fc( aL .0o - w Cu .- * -1 u a w u >- :>.4 ai > -5 a WQ >a a aLI 0 OL 5-0 ;pI- I. > .-. I-. Mi Qa. "LA - v *- 0 -u

  15. Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

    NASA Astrophysics Data System (ADS)

    Gonzalez Ortiz, Andrea

    2017-01-01

    We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

  16. Sandia National Laboratories: News: Image Gallery

    Science.gov Websites

    Environmental Management System Pollution Prevention History 60 impacts Diversity Locations Facts & Figures Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers

  17. Guidance, Navigation and Control Digital Emulation Technology Laboratory. Volume 1. Part 2. Task 1: Digital Emulation Technology Laboratory

    DTIC Science & Technology

    1991-09-27

    AD-A241 692 II I] II I11 ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATOIRY REPORT NO. AR-0142-91-001 September 27, 1991... DIGITAL EMULATION TECHNOLOGY LABORATORY Contract No. DASG60-89-C-0142 Sponsored By The United States Army ? trategic Defense Command COMPUTER...ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATORY September 27, 1991 Authors Thomas R. Collins and Stephen R. Wachtel

  18. Northwest view of Pakistan, eastern Iran and Afghanistan during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06443 (15-16 May 1963) --- A northwest-looking view across Pakistan, eastern Iran and Afghanistan as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  19. National survey on intra-laboratory turnaround time for some most common routine and stat laboratory analyses in 479 laboratories in China.

    PubMed

    Fei, Yang; Zeng, Rong; Wang, Wei; He, Falin; Zhong, Kun; Wang, Zhiguo

    2015-01-01

    To investigate the state of the art of intra-laboratory turnaround time (intra-TAT), provide suggestions and find out whether laboratories accredited by International Organization for Standardization (ISO) 15189 or College of American Pathologists (CAP) will show better performance on intra-TAT than non-accredited ones. 479 Chinese clinical laboratories participating in the external quality assessment programs of chemistry, blood gas, and haematology tests organized by the National Centre for Clinical Laboratories in China were included in our study. General information and the median of intra-TAT of routine and stat tests in last one week were asked in the questionnaires. The response rate of clinical biochemistry, blood gas, and haematology testing were 36% (479/1307), 38% (228/598), and 36% (449/1250), respectively. More than 50% of laboratories indicated that they had set up intra-TAT median goals and almost 60% of laboratories declared they had monitored intra-TAT generally for every analyte they performed. Among all analytes we investigated, the intra-TAT of haematology analytes was shorter than biochemistry while the intra-TAT of blood gas analytes was the shortest. There were significant differences between median intra-TAT on different days of the week for routine tests. However, there were no significant differences in median intra-TAT reported by accredited laboratories and non-accredited laboratories. Many laboratories in China are aware of intra-TAT control and are making effort to reach the target. There is still space for improvement. Accredited laboratories have better status on intra-TAT monitoring and target setting than the non-accredited, but there are no significant differences in median intra-TAT reported by them.

  20. National survey on intra-laboratory turnaround time for some most common routine and stat laboratory analyses in 479 laboratories in China

    PubMed Central

    Fei, Yang; Zeng, Rong; Wang, Wei; He, Falin; Zhong, Kun

    2015-01-01

    Introduction To investigate the state of the art of intra-laboratory turnaround time (intra-TAT), provide suggestions and find out whether laboratories accredited by International Organization for Standardization (ISO) 15189 or College of American Pathologists (CAP) will show better performance on intra-TAT than non-accredited ones. Materials and methods 479 Chinese clinical laboratories participating in the external quality assessment programs of chemistry, blood gas, and haematology tests organized by the National Centre for Clinical Laboratories in China were included in our study. General information and the median of intra-TAT of routine and stat tests in last one week were asked in the questionnaires. Results The response rate of clinical biochemistry, blood gas, and haematology testing were 36% (479 / 1307), 38% (228 / 598), and 36% (449 / 1250), respectively. More than 50% of laboratories indicated that they had set up intra-TAT median goals and almost 60% of laboratories declared they had monitored intra-TAT generally for every analyte they performed. Among all analytes we investigated, the intra-TAT of haematology analytes was shorter than biochemistry while the intra-TAT of blood gas analytes was the shortest. There were significant differences between median intra-TAT on different days of the week for routine tests. However, there were no significant differences in median intra-TAT reported by accredited laboratories and non-accredited laboratories. Conclusions Many laboratories in China are aware of intra-TAT control and are making effort to reach the target. There is still space for improvement. Accredited laboratories have better status on intra-TAT monitoring and target setting than the non-accredited, but there are no significant differences in median intra-TAT reported by them. PMID:26110033

  1. SCHeMA web-based observation data information system

    NASA Astrophysics Data System (ADS)

    Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

    2016-04-01

    It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by

  2. New Constraints on the Abundance of 60Fe in the Early Solar System

    NASA Astrophysics Data System (ADS)

    Trappitsch, Reto; Boehnke, Patrick; Stephan, Thomas; Telus, Myriam; Savina, Michael R.; Pardo, Olivia; Davis, Andrew M.; Dauphas, Nicolas; Pellin, Michael J.; Huss, Gary R.

    2018-04-01

    Establishing the abundance of the extinct radionuclide 60Fe (half-life 2.62 Ma) in the early solar system is important for understanding the astrophysical context of solar system formation. While bulk measurements of early solar system phases show a low abundance consistent with galactic background, some in situ measurements by secondary ion mass spectrometry (SIMS) imply a higher abundance, which would require injection from a nearby supernova (SN). Here we present in situ nickel isotopic analyses by resonance ionization mass spectrometry (RIMS) in a chondrule from the primitive meteorite Semarkona (LL3.00). The same chondrule had been previously analyzed by SIMS. Despite improved precision compared to SIMS, the RIMS nickel isotopic data do not reveal any resolved excesses of 60Ni that could be unambiguously ascribed to in situ 60Fe decay. Linear regression of 60Ni/58Ni versus 56Fe/58Ni yields an initial 60Fe/56Fe ratio for this chondrule of (3.8 ± 6.9) × 10‑8, which is consistent with both the low initial value found by bulk measurements and the low end of the range of initial ratios inferred from some in situ work. The same regression also gives a solar initial 60Ni/58Ni ratio, which shows that this sample was not disturbed by nickel mobilization, thus agreeing with a low initial 60Fe/56Fe ratio. These findings agree with a re-evaluation of previous SIMS measurements of the same sample. Supernova injection of 60Fe into the solar system or its parental cloud material is therefore not necessary to account for the measured solar system’s initial amount of 60Fe.

  3. Teacher MA Attainment Rates, 1970-2000

    ERIC Educational Resources Information Center

    Larsen, S. Eric

    2010-01-01

    The share of female teachers in the U.S. with an MA more than doubled between 1970 and 2000. This increase is puzzling, as it is much larger than that of other college-educated women, and it occurred over a period of declining teacher aptitude. I estimate the contribution of changes in teacher demographic characteristics, increases in the returns…

  4. Isomeric and Isotopic Effects on the Electronic Spectrum of {{\\rm{C}}}_{60}^{+}–He: Consequences for Astronomical Observations of {{\\rm{C}}}_{60}^{+}

    NASA Astrophysics Data System (ADS)

    Campbell, E. K.; Maier, J. P.

    2018-05-01

    Laboratory measurements are reported that enable a more accurate determination of the characteristics of the near-infrared absorptions of {{{C}}}60+ below 10 K. These data were obtained by photofragmentation of {{{C}}}60+{--}{He} complexes in a cryogenic trap. Asymmetry in the profiles of the observed 9577 and 9632 Å absorption bands of {{{C}}}60+{--}{He} is caused by the attachment of the weakly bound helium atom to hexagonal or pentagonal faces of {{{C}}}60+. The implication is that the FWHM of the bands in the electronic spectrum of {{{C}}}60+ below 10 K is 1.4 Å. The effect of 13C isotopes on the {{{C}}}60+ electronic spectrum is experimentally evaluated by measurement of {}12{{{C}}}60+{--}{He}, {}13{{{C}}}112{{{C}}}59+{--}{He}, and {}13{{{C}}}212{{{C}}}58+{--}{He}. Data on the 9365 Å absorption band indicate a wavelength shift of about 0.3 Å between the former and latter. This result is consistent with models used to interpret the vibrational isotope effect in the Raman spectrum of neutral C60. The influence of 13C isotopes on the 9348, 9365, 9428, 9577, and 9632 Å diffuse interstellar bands is expected to be minor considering other broadening factors that affect astronomical observations. The presented data also provide more accurate relative intensities of the five interstellar bands attributed to {{{C}}}60+.

  5. Explorer 1 60th Anniversary

    NASA Image and Video Library

    2018-01-31

    Michael Watkins, Director of NASA's Jet Propulsion Laboratory, left, Susan Finley, who began working at NASA's Jet Propulsion Laboratory in January 1958 as a "human computer", center, and Thomas Zurbuchen, Associate Administrator for NASA's Science Mission Directorate, right, reenact the famous picture of Dr. William H. Pickering, Dr. James A. van Allen, and Dr. Wernher von Braun, hoisting a model of Explorer 1 above their heads at a press conference announcing the satellite's success with a replica of the Explorer 1 satellite during an event celebrating the 60th Anniversary of the Explorer 1 mission and the discovery of Earth's radiation belts, Wednesday, Jan. 31, 2018, at the National Academy of Sciences in Washington. The first U.S. satellite, Explorer 1, was launched from Cape Canaveral on January 31, 1958. The 30-pound satellite would yield a major scientific discovery, the Van Allen radiation belts circling our planet, and begin six decades of groundbreaking space science and human exploration. (NASA/Joel Kowsky)

  6. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody

    PubMed Central

    Barnett, M; Prosser, J; Sutton, I; Halmagyi, G; Davies, L; Harper, C; Dalmau, J

    2001-01-01

    A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

 PMID:11160472

  7. Kuznetsov-Ma waves train generation in a left-handed material

    NASA Astrophysics Data System (ADS)

    Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

    2015-03-01

    We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

  8. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

    PubMed

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M; Weissman, Jonathan S; Rouskin, Silvi

    2017-01-01

    Coupling of structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structure studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduce biases and necessitate population-average assessments of RNA structure. Here we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase. DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low-abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in noncanonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms. These applications illustrate DMS-MaPseq's capacity to dramatically expand in vivo analysis of RNA structure.

  9. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo

    PubMed Central

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M.; Weissman, Jonathan S.; Rouskin, Silvi

    2017-01-01

    Coupling structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structural studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduces biases and necessitates population-average assessments of RNA structure. Here we present dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase (TGIRT). DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in non-canonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs to their mature isoforms. These applications illustrate DMS-MaPseq’s capacity to dramatically expand in vivo analysis of RNA structure. PMID:27819661

  10. 75 FR 3764 - Massachusetts Disaster # MA-00024

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12020 and 12021] Massachusetts Disaster MA-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 01/15/2010. Incident: Mystic...

  11. 77 FR 76584 - Massachusetts Disaster # MA-00051

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13420 and 13421] Massachusetts Disaster MA-00051 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/12/2012. Incident...

  12. 76 FR 30748 - Massachusetts Disaster #MA-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declarations 12597 and 12598] Massachusetts Disaster MA-00033 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/19/2011. Incident...

  13. 76 FR 65557 - Massachusetts Disaster #MA-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12884 and 12885] Massachusetts Disaster MA-00043 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 10/13/2011. [[Page 65558...

  14. 77 FR 76585 - Massachusetts Disaster # MA-00052

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13417 and 13418] Massachusetts Disaster MA-00052 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/11/2012. Incident...

  15. 77 FR 2600 - Massachusetts Disaster #MA-00046

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12984 and 12985] Massachusetts Disaster MA-00046 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  16. 77 FR 33263 - Massachusetts Disaster #MA-00048

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13078 and 13079] Massachusetts Disaster MA-00048 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/29/2012. Incident: Lake...

  17. 76 FR 13697 - Massachusetts Disaster #MA-00032

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12484 and 12485] Massachusetts Disaster MA-00032 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  18. 78 FR 25336 - Massachusetts Disaster #MA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13549 and 13550] Massachusetts Disaster MA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Massachusetts...

  19. 77 FR 12350 - Massachusetts Disaster #MA-00047

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13021 and 13022] Massachusetts Disaster MA-00047 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 02/21/2012. Incident...

  20. 76 FR 36952 - Massachusetts Disaster #MA-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12639 and 12640] Massachusetts Disaster MA-00037 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...