Lawrence Livermore National Laboratory safeguards and security quarterly progress report to the U.S. Department of Energy. Quarter ending December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, G.; Mansur, D.L.; Ruhter, W.D.

The Lawrence Livermore National Laboratory (LLNL) carries out safeguards and security activities for the Department of Energy (DOE), Office of Safeguards and Security (OSS), as well as other organizations, both within and outside the DOE. This document summarizes the activities conducted for the OSS during the First Quarter of Fiscal Year 1997 (October through December, 1996). The nature and scope of the activities carried out for OSS at LLNL require a broad base of technical expertise. To assure projects are staffed and executed effectively, projects are conducted by the organization at LLNL best able to supply the needed technical expertise.more » These projects are developed and managed by senior program managers. Institutional oversight and coordination is provided through the LLNL Deputy Director`s office. At present, the Laboratory is supporting OSS in four areas: (1) safeguards technology; (2) safeguards and material accountability; (3) computer security--distributed systems; and (4) physical and personnel security support. The remainder of this report describes the activities in each of these four areas. The information provided includes an introduction which briefly describes the activity, summary of major accomplishments, task descriptions with quarterly progress, summaries of milestones and deliverables and publications published this quarter.« less

Heavy Ion Fusion Science Virtual National Laboratory 4th Quarter 2009 Milestone Report: Measure and simulate target temperature and dynamic response in optimized NDCX-I configurations with initial diagnostics suite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bieniosek, F.M.; Barnard, J.J.; Henestroza, E.

2009-09-30

This milestone has been met. The effort contains two main components: (1) Experimental results of warm dense matter target experiments on optimized NDCX-I configurations that include measurements of target temperature and transient target behavior. (2) A theoretical model of the target response to beam heating that includes an equilibrium heating model of the target foil and a model for droplet formation in the target for comparison with experimental results. The experiments on ion-beam target heating use a 300-350-keV K{sup +} pulsed beam from the Neutralized Compression Drift Experiment (NDCX-I) accelerator at LBNL. The NDCX-I accelerator delivers an uncompressed pulse beammore » of several microseconds with a typical power density of >100 kW/cm{sup 2} over a final focus spot size of about 1 mm. An induction bunching module the NDCX-I compresses a portion of the beam pulse to reach a much higher power density over 2 nanoseconds. Under these conditions the free-standing foil targets are rapidly heated to temperatures to over 4000 K. We model the target thermal dynamics using the equation of heat conduction for the temperature T(x,t) as a function of time (t) and spatial dimension along the beam direction (x). The competing cooling processes release energy from the surface of the foil due to evaporation, radiation, and thermionic (Richardson) emission. A description of the experimental configuration of the target chamber and results from initial beam-target experiments are reported in our FY08 4th Quarter and FY09 2nd Quarter Milestone Reports. The WDM target diagnostics include a high-speed multichannel optical pyrometer, optical streak camera, VISAR, and high-speed gated cameras. The fast optical pyrometer is a unique and significant new diagnostic which provides valuable information on the temperature evolution of the heated target.« less

Assessment of an Engineering Technology Outreach Program for 4th-7th Grade Girls

ERIC Educational Resources Information Center

Dell, Elizabeth M.; Christman, Jeanne; Garrick, Robert D.

2011-01-01

This paper describes a workshop led by female Engineering Technology students, with support from female faculty, to provide an introduction to Engineering Technology to 4th-7th grade girls through a series of interactive laboratory experiments. This outreach program was developed to improve attitudes towards science and engineering in middle…

Smith Newton Vehicle Performance Evaluation – 4th Quarter 2013; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-01-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

17. 4th floor roof, view south, 4th and 5th floor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. 4th floor roof, view south, 4th and 5th floor setback to left and atrium structure to right - Sheffield Farms Milk Plant, 1075 Webster Avenue (southwest corner of 166th Street), Bronx, Bronx County, NY

45 CFR 265.4 - When are quarterly reports due?

Code of Federal Regulations, 2010 CFR

2010-10-01

... COLLECTION AND REPORTING REQUIREMENTS § 265.4 When are quarterly reports due? (a) Each State must file the TANF Data Report and the TANF Financial Report (or, as applicable, the Territorial Financial Report... 45 Public Welfare 2 2010-10-01 2010-10-01 false When are quarterly reports due? 265.4 Section 265...

Quarterly environmental data summary for first quarter 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the first quarter of 1999 is enclosed. The data presented in this constitute the QEDS. The data, except for air monitoring data and site KPA generated data (uranium analyses), were received from the contract laboratories, verified by the Weldon Spring Site verification group and merged into the database during the first quarter of 1999. KPA results for on-site total uranium analyses performed during first quarter 1999 are included. Air monitoring data presented are the most recent completemore » sets of quarterly data.« less

12 CFR 997.4 - Calculation of the quarterly present-value determination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Calculation of the quarterly present-value determination. 997.4 Section 997.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD NON-BANK SYSTEM ENTITIES RESOLUTION FUNDING CORPORATION OBLIGATIONS OF THE BANKS § 997.4 Calculation of the quarterly present-value...

iMAST Quarterly, Number 4, 1999

DTIC Science & Technology

1999-01-01

ELEMENT NUMBER 6 . AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Penn State... 6 Calendar of Events .............................................. 8 Good-bye We are rapidly approaching the end of 1999 and...U.Ed. ARL 00- 6 DIRECTOR’S CORNER iMAST Quarterly 1999 No. 4 3 FEATURE ARTICLE Focus on Environmentally Friendly Technologies Automated Paint

Hawaiian Volcano Observatory 1960 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1959 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1971 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1961 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1958 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1962 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1970 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1973 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1966 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1965 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1964 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1957 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1972 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1969 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1967 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1968 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

Hawaiian Volcano Observatory 1963 Quarterly Administrative Report

USGS Publications Warehouse

Nakata, Jennifer S.

2007-01-01

INTRODUCTORY NOTE The Hawaiian Volcano Observatory Summaries have been published in the current format since 1956. The Quarterly Summaries (1956 through 1973) and the Annual Summaries (1974 through 1985) were originally published as Administrative Reports. These reports have been compiled and published as U.S. Geological Survey Open-File Reports. The quarterly reports have been combined and published as one annual summary. All the summaries from 1956 to the present are now available as .pdf files at http://www.usgs.gov/pubprod. The earthquake summary data are presented as a listing of origin time, depth, magnitude, and other location parameters. Network instrumentation, field station sites, and location algorithms are described. Tilt and other deformation data are included until Summary 77, January to December 1977. From 1978, the seismic and deformation data are published separately, due to differing schedules of data reduction. There are eight quarters - from the fourth quarter of 1959 to the third quarter of 1961 - that were never published. Two of these (4th quarter 1959, 1st quarter 1960) have now been published, using handwritten notes of Jerry Eaton (HVO seismologist at the time) and his colleagues. The seismic records for the remaining six summaries went back to California in 1961 with Jerry Eaton. Other responsibilities intervened, and the seismic summaries were never prepared.

45 CFR 265.4 - When are quarterly reports due?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true When are quarterly reports due? 265.4 Section 265.4 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES DATA COLLECTION AND REPORTING REQUIREMENTS § 265.4 When are...

27 CFR 53.157 - Deposit requirement for deposits made for calendar quarters prior to July 1, 1995.

Code of Federal Regulations, 2010 CFR

2010-04-01

... calendar quarter, the person deposits any underpayment for the month by the 9th day of the second month... quarter, the person deposits any underpayment for such month by the 9th day of the second month following... month in a calendar quarter, the person deposits any underpayment for such month by the 9th day of the...

THE FIRST LASING OF 193 NM SASE, 4TH HARMONIC HGHG AND ESASE AT THE NSLS SDL.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANG, X.J.; SHEN Y.; WATANABE, T.

2006-08-28

The first lasing of three types of single-pass high-gain FELs, SASE at 193 nm, 4th harmonic HGHG at 199 nm and ESASE at the Source Development Lab (SDL) of Brookhaven National Laboratory (BNL) is reported. The saturation of 4th harmonic HGHG and ESASE FELs was observed. We also observed the spectral broadening and instability of the 4th harmonic HGHG.

166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH AVE. FROM BUILDING 44 SHOWING, FROM LEFT TO RIGHT, BUILDING 46, 48, 55, AND 50 (PART OF ENLISTED BARRACKS COMPLEX), AND BUILDINGS 17, 16, 484, 483, 374, AND 375 (IN THE WAREHOUSE COMPLEX). - Quonset Point Naval Air Station, Roger Williams Way, North Kingstown, Washington County, RI

Collaborative study for the establishment of the 4(th) International Standard for Streptomycin.

PubMed

Jorajuria, S; Raphalen, C; Dujardin, V; Daas, A

2015-01-01

An international collaborative study was organised to establish the 4(th) World Health Organization (WHO) International Standard (IS) for Streptomycin. Fourteen laboratories from different countries participated. Potencies of the candidate material were estimated by microbiological assays with sensitive micro-organisms. To ensure continuity between consecutive batches, the 3(rd) IS for Streptomycin was used as a reference. Based on the results of the study, the 4(th) IS for Streptomycin was adopted at the meeting of the WHO Expert Committee for Biological Standardization (ECBS) in 2015 with an assigned potency of 76 000 International Units (IU) per vial. The 4(th) IS for Streptomycin is available from the European Directorate for the Quality of Medicines & HealthCare (EDQM).

Celebrating the 125th anniversary of the American Psychological Association: A quarter century of neuropsychology.

PubMed

Brown, Gregory G; Anderson, Vicki; Bigler, Erin D; Chan, Agnes S; Fama, Rosemary; Grabowski, Thomas J; Zakzanis, Konstantine K

2017-11-01

The American Psychological Association (APA) celebrated its 125th anniversary in 2017. As part of this celebration, the APA journal Neuropsychology has published in its November 2017 issue 11 papers describing some of the advances in the field of neuropsychology over the past 25 years. The papers address three broad topics: assessment and intervention, brain imaging, and theory and methods. The papers describe the rise of new assessment and intervention technologies, the impact of evidence for neuroplasticity on neurorehabilitation. Examples of the use of mathematical models of cognition to investigate latent neurobehavioral processes, the development of the field of neuropsychology in select international countries, the increasing sophistication of brain imaging methods, the recent evidence for localizationist and connectionist accounts of neurobehavioral functioning, the advances in neurobehavioral genomics, and descriptions of newly developed statistical models of longitudinal change. Together the papers convey evidence of the vibrant growth in the field of neuropsychology over the quarter century since APA's 100th anniversary in 1992. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

The WSTIAC Quarterly. Volume 9, Number 4

DTIC Science & Technology

2010-04-28

elements of command– Major Eric D. Trias Captain Bryan M. Bell US Air Force You have to know the past to understand the present. — Carl Sagan This article is...Quarterly, Volume 9, Number 4 3 INTRODUCTION Carl von Clausewitz defined war as “…an act of violence intended to compel our opponent to fulfill our will...controlled systems. NOTES & REFERENCES ‡ Joint Pub 3-13 provides the doctrinal foundation for the conduct of IO in joint operations. [1] von Clausewitz, Carl

Trustee Quarterly: Volume 5, Numbers 1-4, 1980-1981.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1981-01-01

These four issues of "Trustee Quarterly" present 31 articles on topics of concern to community college trustees, including finance, administration, and mission. Specific articles cover: (1) the board chair's political role (E. M. Duffy); (2) evaluation and goal setting (M. Hays); (3) collective bargaining (K. L. Hunt and W. Hamilton); (4) long-…

Preferential susceptibility of Th9 and Th2 CD4+ T cells to X4-tropic HIV-1 infection.

PubMed

Orlova-Fink, Nina; Chowdhury, Fatema Z; Sun, Xiaoming; Harrington, Sean; Rosenberg, Eric S; Yu, Xu G; Lichterfeld, Mathias

2017-10-23

The functional polarization of CD4 T cells determines their antimicrobial effector profile, but may also impact the susceptibility to infection with HIV-1. Here, we analyzed the susceptibility of CD4 T cells with different functional polarization to infection with X4 and R5-tropic HIV-1. CD4 T cells with a Th1, Th2, Th17, and Th9 polarization were subjected to in-vitro infection assays with X4, R5, or vesicular stomatitis virus-G protein-pseudotyped HIV-1. In addition, we sorted differentially polarized CD4 T-cell subsets from individuals treated with antiretroviral therapy and analyzed the tropism of viral env sequences. Th9-polarized CD4 T cells and, to a lesser extent, Th2-polarized CD4 T cells expressed higher surface levels of CXCR4, and are more permissive to X4-tropic infection in vitro. In contrast, Th1 and Th17 CD4 T cells exhibited stronger surface expression of CCR5, and were more susceptible to infection with R5-tropic viruses. Correspondingly, the distribution of X4-tropic viral sequences in antiretroviral therapy-treated HIV-1-infected patients was biased toward Th9/Th2 cells, whereas R5-tropic sequences were more frequently observed in Th17 cells. CD4 T-cell polarization is associated with a distinct susceptibility to X4 and R5-tropic HIV-1 infection.

Quarterly environmental data summary for first quarter 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-05-01

In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the first quarter of 1998 is enclosed. The data presented in this letter and attachment constitute the QEDS. The data were received from the contract laboratories, verified by the Weldon Spring Site verification group and, except for air monitoring data and site KPA generated data (uranium analyses), merged into the data base during the first quarter of 1998. Air monitoring data presented are the most recent complete sets of quarterly data. Air data are not stored inmore » the data base, and KPA data are not merged into the regular data base. Significant data, defined as data values that have exceeded defined {open_quotes}above normal{close_quotes} Level 2 values, are discussed in this letter for Environmental Monitoring Plan (EMP) generated data only. Above normal Level 2 values are based, in ES&H procedures, on historical high values, DOE Derived Concentration Guides (DCGs), NPDES limits and other guidelines. The procedures also establish actions to be taken in the event that {open_quotes}above normal{close_quotes} data occur. All data received and verified during the first quarter were within a permissible range of variability except for those detailed below. Above normal occurrences are cited for groundwater, air, and NPDES data. There were none for springs or surface water. The following discussion offers a brief summary of the data merged during the first quarter that exceeded the above normal criteria and updates on past reported above normal data. The attached tables present the most recent data for air and the data merged into the data base during the first quarter 1998 for groundwater, NPDES, surface water, and springs. Graphs showing concentrations of selected contaminants of concern at some of the critical locations have also been included in this QEDS. The graphs are discussed in the separate

Storm Peak Laboratory 5th-6th Grade Climate and Weather Program

NASA Astrophysics Data System (ADS)

McCubbin, I. B.; Hallar, A. G.

2008-12-01

Storm Peak Laboratory (SPL) has created a place-based elementary school program, which has been implemented at five elementary schools in Northwest Colorado. Real understanding, not factual recall, is the primary goal and developing a desire to be lifelong learners in science is a secondary goal. The specific objectives of the program include the following: 1) Develop a weather and climate curriculum that teaches skills required by Colorado Student Assessment Program (CSAP). 2) Provide a hands-on place-based educational experience where students have an opportunity to use scientific equipment. 3) Provide students a three-day program that consists of an introduction, field program, and follow-up to help students grasp concepts and apply them to other school studies. 4) Provide all participating students with understanding of climate and weather 5) Build foundations for students to understand climate change. 6) Disseminate to alpine regions across the Western US, potentially impacting thousands of students that will experience the impacts of climate change during their lifetime. The SPL program spans three days for each school and includes five elementary schools. During the first day, a scientist and educators from SPL visit each classroom for two hours to introduce the concepts of climate and weather as well as teach students how to use scientific equipment. During the field program on the second day, students measure and record information about temperature, pressure, relative humidity, wind speed, and particle concentration while they travel to SPL via the gondola and chair lifts (in winter) or 4WD Suburbans (in fall). Once at the laboratory, students will meet with both SPL scientists and educators to tour the facility, discuss SPL research activities, and explore application of these activities to their curriculum. An alternative winter snowshoe program at the top of the gondola is offered to students who do not ski, where students have a program on snow

Frontiers: Research highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-31

This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

Frontiers: Research Highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

DOE R&D Accomplishments Database

1996-01-01

This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

English Leadership Quarterly, 2001-2002.

ERIC Educational Resources Information Center

Kiernan, Henry, Ed.; Wilcox, Bonita L., Ed.

2002-01-01

This 24th volume of "English Leadership Quarterly" contains articles on topics of interest to those in positions of leadership in departments (elementary, secondary, or college) where English is taught. Each issue focuses on a different theme. Articles in Volume 24 Number 1 focus on matters of thinking and are: "A New Way of…

Environmental Restoration Operations: Consolidated Quarterly Report January -March 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the January, February, and March 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwatermore » [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III. This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent.« less

ACCT Trustee Quarterly; Volume 6, Numbers 1-4, l981-1982.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1982-01-01

These four issues of "ACCT Trustee Quarterly" present 35 articles on topics of concern to community college trustees, including finance, administration, and mission. Specific articles cover: (1) public relations (C. Akemann and M. Hopkins); (2) president selection (A. Bailey); (3) board/president relations (D. Bryant); (4) educators as trustees…

REACTOR PHYSICS QUARTERLY REPORT JANUARY, FEBRUARY, MARCH 1970

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmid, L. C.; Clayton, E. D.; Heineman, R. E.

1970-05-01

The objective of the Reactor Physics Quarterly Report is to inform the scientific community in a timely manner of the technical progress made on the many phases of reactor physics work within the laboratory. The report contains brief technical discussions of accomplishments in all areas where significant progress has been made during the quarter.

Caudal lumbar vertebral fractures in California Quarter Horse and Thoroughbred racehorses.

PubMed

Collar, E M; Zavodovskaya, R; Spriet, M; Hitchens, P L; Wisner, T; Uzal, F A; Stover, S M

2015-09-01

To gain insight into the pathophysiology of equine lumbar vertebral fractures in racehorses. To characterise equine lumbar vertebral fractures in California racehorses. Retrospective case series and prospective case-control study. Racehorse post mortem reports and jockey injury reports were retrospectively reviewed. Vertebral specimens from 6 racehorses affected with lumbar vertebral fractures and 4 control racehorses subjected to euthanasia for nonspinal fracture were assessed using visual, radiographic, computed tomography and histological examinations. Lumbar vertebral fractures occurred in 38 Quarter Horse and 29 Thoroughbred racehorses over a 22 year period, primarily involving the 5th and/or 6th lumbar vertebrae (L5-L6; 87% of Quarter Horses and 48% of Thoroughbreds). Lumbar vertebral fractures were the third most common musculoskeletal cause of death in Quarter Horses and frequently involved a jockey injury. Lumbar vertebral specimens contained anatomical variations in the number of vertebrae, dorsal spinous processes and intertransverse articulations. Lumbar vertebral fractures examined in 6 racehorse specimens (5 Quarter Horses and one Thoroughbred) coursed obliquely in a cranioventral to caudodorsal direction across the adjacent L5-L6 vertebral endplates and intervertebral disc, although one case involved only one endplate. All cases had evidence of abnormalities on the ventral aspect of the vertebral bodies consistent with pre-existing, maladaptive pathology. Lumbar vertebral fractures occur in racehorses with pre-existing pathology at the L5-L6 vertebral junction that is likely predisposes horses to catastrophic fracture. Knowledge of these findings should encourage assessment of the lumbar vertebrae, therefore increasing detection of mild vertebral injuries and preventing catastrophic racehorse and associated jockey injuries. © 2014 EVJ Ltd.

Joint Force Quarterly. Issue 59, 4th Quarter 2010

DTIC Science & Technology

2010-10-01

also be used as part of stealth technology in helicopters to create white noise to cancel or hide the sound of the rotor blades . These magnets are... deficit , the size of the defense budget, and the need to reduce and control costs: DOD Directive 1200.17 recognized that the Reserve Components...Senator Frank Church, inves- tigating intelligence blunders that surfaced in the wake of the Watergate investigation. Now a RAND researcher with many

Joint Force Quarterly. Issue 43, 4th Quarter 2006

DTIC Science & Technology

2006-01-01

plan in Iraq, and it echoed the millennial slogan, “It’s the economy, stupid!” Naomi Klein offers the poignant observa- tion that injecting greed and...closer study. Alternatively, creating a two-tier market system that makes the cost of business unsus- tainable for informal market entrepreneurs is one

Joint Force Quarterly. Issue 55, 4th Quarter 2009

DTIC Science & Technology

2009-01-01

average 1 hour per response, including the time for reviewing instructions, searching existing data sources , gathering and maintaining the data needed...to critique systems theory from some of its source documents, he could have accessed the many works of scientists and philosophers such as Russell...numerous sources , including writings of some leading systems theorists. It is simply false to claim, as Professor Czarnecki does (and many systems

Joint Force Quarterly. Issue 63, 4th Quarter 2011

DTIC Science & Technology

2011-10-01

wondrous trinity” for use in the current threat environment, Mr. Owens could refer to my piece entitled “The Age of Irregular Warfare: So What...listen, but its future enemy did. When it comes to good ideas, neither rank nor age confers a monopoly. JFQ is intended to stay at the vanguard, to...will need to evolve with an emphasis on rejuvenating and sustaining the country’s economic vitality while relying increasingly on credible forms of

The Leap into 4th Grade

ERIC Educational Resources Information Center

Anderson, Mike

2011-01-01

Fourth grade is a pivotal year, in which students commonly face increased academic demands. According to Anderson, teachers can help students make a smooth transition to 4th grade by introducing these new challenges in ways that are in line with 4th graders' common developmental characteristics: incredible energy and emotion, industriousness and…

Energy and Environmental Insecurity (Joint Force Quarterly, Issue 55, 4th Quarter 2009)

DTIC Science & Technology

2009-01-01

Energy and Environmental Insecurity By r i c h a r D B . a n D r e s Dr. Richard B. Andres is Energy and Environment Security and Policy Chair in...security, they are as likely referring to carbon emissions as to energy self -reliance and affordable oil. Moreover, the solutions that the international...2009 4. TITLE AND SUBTITLE Energy and Environmental Insecurity 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

Consolidated Quarterly Report: Number of potential release sites subject to corrective action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2017-04-01

This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent. The 12 sites in the corrective action process are listed in Table I-1.

Francis Bitter National Laboratory quarterly progress report, July 1, 1972--September 30, 1972

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1972-10-31

Reports on research projects at Francis Bitter National Magnet Laboratory are presented on 19 different topics including the following: far infrared magneto-optics; quantum optics; soft x-rays and laser-produced plasmas; magneto-optical theory; magnetism and superconductivity; Mossbauer effect studies; superconducting thin films; amorphous semiconductors and superconductivity; nuclear magnetic resonance of biomolecules; low magnetic fields; superconducting medical magnet; magnetically guided catheters; magnetic separation; high current switching; development of guided electromagnetic flight; Alcator; high voltage discharges in cryocables; and low temperature thermometry in high magnetic fields. The Magnet Research and Technology Program and reports of visiting scientists are also included in this report. Reportsmore » on some research not supported by NSF are included, and the supporting agencies are indicated. A list of publications and speeches presented at meetings during the quarter covered by this report are included in an appendix.« less

Ab initio studies of Th3N4, Th2N3 and Th2N2(NH)

NASA Astrophysics Data System (ADS)

Obodo, K. O.; Chetty, N.

2014-09-01

Using density functional theory within the Perdew-Burke-Ernzerhof generalized gradient approximation [GGA (PBE)] implemented in the VASP codes, we investigate the structural, elastic and electronic properties of Th3N4, Th2N3 and Th2N2(NH). The calculated structural properties of these thorium-based nitrides are in good agreement with experimental data. We observe that all the Th-N based compounds that we considered are energetically favorable and elastically stable. We find that Th3N4 is semiconducting with a band gap of 1.59 eV, which compares well with the experimental band gap of 1.7 eV and we find Th2N3 to be metallic. Th2N2(NH), which is crystallographically equivalent to Th2N3, is insulating with a band gap of 2.12 eV. This is due to the -(NH) group that effects a shifting of the energy bands that results in the opening of a gap at the Fermi-level. The Th-N based compounds that we considered are predominantly ionic.

Weldon Spring Site Remedial Action Project Federal Facilities Agreement: Quarterly environmental data summary for third quarter 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-11-06

In support of the Weldon Spring Site Remedial Action Project Federal Facilities Agreement, a copy of the Quarterly Environmental Data Summary (QEDS) for the third quarter of 1998 is enclosed. The data presented in this letter and attachment constitute the QEDS. The data, except for air monitoring data and site KPA generated data (uranium analyses), were received from the contract laboratories, verified by the Weldon Spring Site verification group, and merged into the database during the third quarter of 1998. Air monitoring data presented are the most recent complete sets of quarterly data. Significant data, defined as data values thatmore » have exceeded defined above normal Level 2 values, are discussed in this letter for Environmental Monitoring Plan (EMP) generated data only. Above normal Level 2 values are based, in ES and H procedures, on historical high values, DOE Derived Concentration Guides (DCGs), NPDES limits, and other guidelines. The procedures also establish actions to be taken in the event that above normal data occur.« less

Trapping of Li(+) Ions by [ThFn](4-n) Clusters Leading to Oscillating Maxwell-Stefan Diffusivity in the Molten Salt LiF-ThF4.

PubMed

Chakraborty, Brahmananda; Kidwai, Sharif; Ramaniah, Lavanya M

2016-08-18

A molten salt mixture of lithium fluoride and thorium fluoride (LiF-ThF4) serves as a fuel as well as a coolant in the most sophisticated molten salt reactor (MSR). Here, we report for the first time dynamic correlations, Onsager coefficients, Maxwell-Stefan (MS) diffusivities, and the concentration dependence of density and enthalpy of the molten salt mixture LiF-ThF4 at 1200 K in the composition range of 2-45% ThF4 and also at eutectic composition in the temperature range of 1123-1600 K using Green-Kubo formalism and equilibrium molecular dynamics simulations. We have observed an interesting oscillating pattern for the MS diffusivity for the cation-cation pair, in which ĐLi-Th oscillates between positive and negative values with the amplitude of the oscillation reducing as the system becomes rich in ThF4. Through the velocity autocorrelation function, vibrational density of states, radial distribution function analysis, and structural snapshots, we establish an interplay between the local structure and multicomponent dynamics and predict that formation of negatively charged [ThFn](4-n) clusters at a higher ThF4 mole % makes positively charged Li(+) ions oscillate between different clusters, with their range of motion reducing as the number of [ThFn](4-n) clusters increases, and finally Li(+) ions almost get trapped at a higher ThF4% when the electrostatic force on Li(+) exerted by various surrounding clusters gets balanced. Although reports on variations of density and enthalpy with temperature exist in the literature, for the first time we report variations of the density and enthalpy of LiF-ThF4 with the concentration of ThF4 (mole %) and fit them with the square root function of ThF4 concentration, which will be very useful for experimentalists to obtain data over a range of concentrations from fitting the formula for design purposes. The formation of [ThFn](4-n) clusters and the reduction in the diffusivity of the ions at a higher ThF4% may limit the

Joint Force Quarterly (Issue 71, 4th Quarter, October 2013)

DTIC Science & Technology

2013-01-01

for a better future and two perspectives in the on-going debate on missile defense in Europe. Drawing on...commended the students for their critical thinking skills and writing talent. In the winning Secretary of Defense essay, Colonel Jonathan Rice...Leadership: Priorities for 21st Century Defense T he Nation and its allies face a strategic turning point that necessitates the optimization of joint and

Joint Force Quarterly. Issue 75, 4th Quarter, October 2014

DTIC Science & Technology

2014-10-01

deployment and retrograde as Operation Enduring Freedom winds down. Manning has varied in step with movement tempo, from the initial cadre of 42 to a high...Additionally, T.X. Hammes of the National Defense University pro- motes a distant blockade of China that “establishes a set of concentric rings that denies...Development (USAID) for construction of the Ring Road because it was deemed a “vital economic trade link” and a “key component to stability and

Joint Force Quarterly. Issue 67, 4th Quarter, October 2012

DTIC Science & Technology

2012-10-01

a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2012 2...Defense Douglas N. Hime Naval War College Mark H. Jacobsen Marine Corps Command and Staff College Daniel T. Kuehl Information Resources Management...Norris Air Command and Staff College Col Mark Pizzo, USMC (Ret.) National War College James A . Schear Office of the Secretary of Defense LtGen Bernard

Joint Force Quarterly. Issue 51, 4th Quarter, October 2008

DTIC Science & Technology

2008-10-01

and Japanese forces to conduct operations in the event of a WMD attack, to include consequence management operations. Recent activities have...strategic challenges. As a supple- ment, we hosted regular professional devel- opment activities, such as Friday afternoon cinema presentations where a

The 4th Thermodynamic Principle?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montero Garcia, Jose de la Luz; Novoa Blanco, Jesus Francisco

2007-04-28

It should be emphasized that the 4th Principle above formulated is a thermodynamic principle and, at the same time, is mechanical-quantum and relativist, as it should inevitably be and its absence has been one of main the theoretical limitations of the physical theory until today.We show that the theoretical discovery of Dimensional Primitive Octet of Matter, the 4th Thermodynamic Principle, the Quantum Hexet of Matter, the Global Hexagonal Subsystem of Fundamental Constants of Energy and the Measurement or Connected Global Scale or Universal Existential Interval of the Matter is that it is possible to be arrived at a global formulationmore » of the four 'forces' or fundamental interactions of nature. The Einstein's golden dream is possible.« less

20. TYPICAL VIEW OF FRONT WINDOWS FROM 4TH TO 9TH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. TYPICAL VIEW OF FRONT WINDOWS FROM 4TH TO 9TH FLOOR WITH WHITE GLAZED TERRA COTTA SILL AND HEADERS. MULLIONS ARE ORANGE BROWN BRICKS LIKE THE WALLS. BRICKS ARE IN FLEMISH BOND PATTERN. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

Education Statistics Quarterly. Volume 5, Issue 4, 2004. NCES 2005-610

ERIC Educational Resources Information Center

National Center for Education Statistics, 2004

2004-01-01

The "Quarterly" offers an accessible, convenient overview of all NCES products released in a given quarter. Each issue includes: short publications (those less than 15 pages in length) in their entirety, executive summaries of longer publications, descriptive paragraphs of other NCES products, as well as notices about training and funding…

Comparing Science Learning among 4th-, 5th-, and 6th-Grade Students: STS versus Textbook-Based Instruction

ERIC Educational Resources Information Center

Yager, Robert E.; Choi, AeRan; Yager, Stuart O.; Akcay, Hakan

2009-01-01

Fifteen 4th-, 5th-, and 6th-grade teachers from five school districts each taught two sections of science--one with a Science-Technology-Society (STS) approach and the other with a more traditional textbook approach in which basic science concepts were the major organizers. Local, current, and personally relevant issues provided the context and…

Defense Attache Saigon: RNAVF Quarterly Assessment. 2nd Quarter FY74.

DTIC Science & Technology

1974-02-01

Military Assistance Command Vietnam MAP Military Assistance Program UNCLASSIFIED F IUNCLASSIFIES MASI Military Assistance Service Funded MATT Military Air...8217 operating the school. The average yearly budget is 2,~4oo,000 piasters, whiuh averages out to less than five cents per student per day. This is... average daily cargo handling rate of 959 M/T for the 2nd quarter FY711 shows continued improvement over the 773 M/T rate attained during the 1st quarter

Calorimetry exchange program amendment to 3rd quarter CY92 report LLNL isotopic data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnett, T.M.

1996-08-01

This report is a series of ammendments to the Calorimetry Exchange Quarterly Data Report for third quarter CY1992. The ammendment is needed due to reporting errors encountered in the Lawrence Livermore National Laboratory isotopic data.

Barratt inside new crew quarters in Kibo

NASA Image and Video Library

2009-09-02

ISS020-E-037855 (2 Sept. 2009) --- NASA astronaut Michael Barratt, Expedition 20 flight engineer, works inside a newly installed crew quarters compartment in the Kibo laboratory of the International Space Station while Space Shuttle Discovery (STS-128) remains docked with the station.

Thermodynamic assessment of the LiF-ThF4-PuF3-UF4 system

NASA Astrophysics Data System (ADS)

Capelli, E.; Beneš, O.; Konings, R. J. M.

2015-07-01

The LiF-ThF4-PuF3-UF4 system is the reference salt mixture considered for the Molten Salt Fast Reactor (MSFR) concept started with PuF3. In order to obtain the complete thermodynamic description of this quaternary system, two binary systems (ThF4-PuF3 and UF4-PuF3) and two ternary systems (LiF-ThF4-PuF3 and LiF-UF4-PuF3) have been assessed for the first time. The similarities between CeF3/PuF3 and ThF4/UF4 compounds have been taken into account for the presented optimization as well as in the experimental measurements performed, which have confirmed the temperatures predicted by the model. Moreover, the experimental results and the thermodynamic database developed have been used to identify potential compositions for the MSFR fuel and to evaluate the influence of partial substitution of ThF4 by UF4 in the salt.

Increase Reading Fluency of 4th and 5th Grade Students with Learning Disabilities Using Readers' Theatre

ERIC Educational Resources Information Center

Mountford, Kathy A.

2007-01-01

The following Action Research Project Report is to improve the oral reading fluency of the 4th and 5th grade students with learning disabilities. The targeted population participating in this study consisted of a total of ten participants of which five were 4th grade students and five were 5th grade students located in a middle class community…

USNAVSO/4th Fleet

Science.gov Websites

. FOURTH Fleet (USNAVSO/FOURTHFLT) employs maritime forces in cooperative maritime security operations in €­(Hidden)‬ USNAVSO/4th Fleet News Retrieving Data Links Secretary of the Navy Chief of Naval Operations Department of Defense U.S. Southern Command SOCIAL MEDIA Quick Links US Navy Recruiting | No Fear Act Data

Conference scene: Summary of the 6th Conference of the Romanian Association of Medical Laboratories with international participation.

PubMed

Carasevici, Eugen

2011-10-01

The Romanian Association of Medical Laboratories (RAML) conferences have acquired a reputation for standing out as the most prominent and efficient meetings in the national community of laboratory medicine, being a landmark of the development in this field in Romania and an active affiliation to international forums. This year, the conference setting was Piatra Neamt, in the northeast part of Romania, which produced a friendly and stimulating professional environment. As in previous years, leading experts in the fields of laboratory medicine attended the event. This year, we enjoyed the opportunity to have such distinguished guests as the members of the executive board of International Federation of Clinical Chemistry and Laboratory Medicine (IFCC); Graham Beastall, IFCC President; Päivi Hannele Laitinen, IFCC secretary; and Grazyna Sypniewska, IFCC Communication and Publication Division, and editor of the electronic journal of the IFCC. As usual, the conference program included all aspects of clinical laboratory activity, with a special focus on technology development, instrumentation and laboratory management. Fully aware of the fact that the complexity and depth of laboratory practice have undergone an impressive and rapid evolution, the specific goals of the event were to increase knowledge in the fundamentals of new molecular investigation, areas which show the tendency to become routine in our daily activity. In addition, laboratory management and the place of medical laboratories in the process of translational medicine were subjects of focus. The 6th Conference of the Romanian Association of Medical Laboratories was held from Wednesday 1st to Saturday 4th of June 2011. A total of 273 participants from all local branches of the Association attended. The scientific program included seven plenary sessions where 22 lectures and 18 short communications were delivered, and three poster sessions with 44 poster presentations. Session topics covered issues of

Systematically frameshifting by deletion of every 4th or 4th and 5th nucleotides during mitochondrial transcription: RNA self-hybridization regulates delRNA expression.

PubMed

Seligmann, Hervé

2016-01-01

In mitochondria, secondary structures punctuate post-transcriptional RNA processing. Recently described transcripts match the human mitogenome after systematic deletions of every 4th, respectively every 4th and 5th nucleotides, called delRNAs. Here I explore predicted stem-loop hairpin formation by delRNAs, and their associations with delRNA transcription and detected peptides matching their translation. Despite missing 25, respectively 40% of the nucleotides in the original sequence, del-transformed sequences form significantly more secondary structures than corresponding randomly shuffled sequences, indicating biological function, independently of, and in combination with, previously detected delRNA and thereof translated peptides. Self-hybridization decreases delRNA abundances, indicating downregulation. Systematic deletions of the human mitogenome reveal new, unsuspected coding and structural informations. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

50 Years of "Reading Research Quarterly" (1965-2014): Looking Back, Moving Forward

ERIC Educational Resources Information Center

Reutzel, D. Ray; Mohr, Kathleen A. J.

2015-01-01

This issue of "Reading Research Quarterly" ("RRQ") marks the journal's golden (50th) anniversary and 200th published issue. Given this historic milestone, an understanding of the journal's content and impact might inform its readership about the field of literacy broadly and the contribution of "RRQ" in…

EMSL Quarterly Highlights Report Second Quarter, Fiscal Year 2010 (January 1, 2010 through March 31, 2010)

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, Staci A.; Showalter, Mary Ann; Manke, Kristin L.

2010-04-20

The Environmental Molecular Sciences Laboratory (EMSL) is a U.S. Department of Energy (DOE) national scientific user facility located at Pacific Northwest National Laboratory (PNNL) in Richland, Washington. EMSL is operated by PNNL for the DOE-Office of Biological and Environmental Research. At one location, EMSL offers a comprehensive array of leading-edge resources and expertise. Access to the instrumentation and expertise is obtained on a peer-reviewed proposal basis. Staff members work with researchers to expedite access to these capabilities. The "EMSL Quarterly Highlights Report" documents current research and activities of EMSL staff and users.

Renewable Energy Finance Tracking Initiative (REFTI): Snapshot of Recent Geothermal Financing Terms, Fourth Quarter 2009 - Second Half 2011

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowder, T.; Hubbell, R.; Mendelsohn, M.

This report is a review of geothermal project financial terms as reported in the National Renewable Energy Laboratory's Renewable Energy Finance Tracking Initiative (REFTI). The data were collected over seven analysis periods from the fourth quarter (Q4) of 2009 to the second half (2H) of 2011.

Augmented Reality for Close Quarters Combat

ScienceCinema

None

2018-01-16

Sandia National Laboratories has developed a state-of-the-art augmented reality training system for close-quarters combat (CQB). This system uses a wearable augmented reality system to place the user in a real environment while engaging enemy combatants in virtual space (Boston Dynamics DI-Guy). Umbra modeling and simulation environment is used to integrate and control the AR system.

The 4th order GISS model of the global atmosphere

NASA Technical Reports Server (NTRS)

Kalnay-Rivas, E.; Bayliss, A.; Storch, J.

1977-01-01

The new GISS 4th order model of the global atmosphere is described. It is based on 4th order quadratically conservative differences with the periodic application of a 16th order filter on the sea level pressure and potential temperature equations, a combination which is approximately enstrophy conserving. Several short range forecasts indicate a significant improvement over 2nd order forecasts with the same resolution (approximately 400 km). However the 4th order forecasts are somewhat inferior to 2nd order forecasts with double resolution. This is probably due to the presence of short waves in the range between 1000 km and 2000 km, which are computed more accurately by the 2nd order high resolution model. An operation count of the schemes indicates that with similar code optimization, the 4th order model will require approximately the same amount of computer time as the 2nd order model with the same resolution. It is estimated that the 4th order model with a grid size of 200 km provides enough accuracy to make horizontal truncation errors negligible over a period of a week for all synoptic scales (waves longer than 1000 km).

Nonanalytic Laboratory Automation: A Quarter Century of Progress.

PubMed

Hawker, Charles D

2017-06-01

Clinical laboratory automation has blossomed since the 1989 AACC meeting, at which Dr. Masahide Sasaki first showed a western audience what his laboratory had implemented. Many diagnostics and other vendors are now offering a variety of automated options for laboratories of all sizes. Replacing manual processing and handling procedures with automation was embraced by the laboratory community because of the obvious benefits of labor savings and improvement in turnaround time and quality. Automation was also embraced by the diagnostics vendors who saw automation as a means of incorporating the analyzers purchased by their customers into larger systems in which the benefits of automation were integrated to the analyzers.This report reviews the options that are available to laboratory customers. These options include so called task-targeted automation-modules that range from single function devices that automate single tasks (e.g., decapping or aliquoting) to multifunction workstations that incorporate several of the functions of a laboratory sample processing department. The options also include total laboratory automation systems that use conveyors to link sample processing functions to analyzers and often include postanalytical features such as refrigerated storage and sample retrieval.Most importantly, this report reviews a recommended process for evaluating the need for new automation and for identifying the specific requirements of a laboratory and developing solutions that can meet those requirements. The report also discusses some of the practical considerations facing a laboratory in a new implementation and reviews the concept of machine vision to replace human inspections. © 2017 American Association for Clinical Chemistry.

Applied Meteorology Unit (AMU) Quarterly Report

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Wheeler, Mark

2011-01-01

This Quarter's Highlights include reports on the following tasks: (1) Mr. Wheeler completed a study for the 30th Weather Squadron at Vandenberg Air Force Base in California in which he found precursors in weather observations that will help the forecasters determine when they will get strong wind gusts at their northern towers. The final report is now on the AMU website at http://science.ksc.nasa.gov/amu/final-reports/30ws-north-base-winds.pdf. (2) continued work on the second phase of verifying the performance of the MesoNAM weather model at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). (3) continued work to improve the AMU peak wind tool by analyzing wind tower data to determine peak wind behavior during times of onshore and offshore flow. (4) continued updating lightning c1imatologies for KSC/CCAFS and other airfields around central Florida and created new c1imatologies for moisture and stability thresholds.

RTO Technical Publications: A Quarterly Listing

NASA Technical Reports Server (NTRS)

2005-01-01

A quarterly listing of RTO technical publications is presented. The topics include: Handbook on the Analysis of Smaller-Scale Contingency Operations in Long Term Defence Planning; 2) Radar Polarimetry and Interferometry; 3) Combat Casualty Care in Ground-Based Tactical Situations: Trauma Technology and Emergency Medical Procedures; and 4) RTO Technical Publications: A Quarterly Listing

H-division quarterly report, October--December 1977. [Lawrence Livermore Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-02-10

The Theoretical EOS Group develops theoretical techniques for describing material properties under extreme conditions and constructs equation-of-state (EOS) tables for specific applications. Work this quarter concentrated on a Li equation of state, equation of state for equilibrium plasma, improved ion corrections to the Thomas--Fermi--Kirzhnitz theory, and theoretical estimates of high-pressure melting in metals. The Experimental Physics Group investigates properties of materials at extreme conditions of pressure and temperature, and develops new experimental techniques. Effort this quarter concerned the following: parabolic projectile distortion in the two-state light-gas gun, construction of a ballistic range for long-rod penetrators, thermodynamics and sound velocities inmore » liquid metals, isobaric expansion measurements in Pt, and calculation of the velocity--mass profile of a jet produced by a shaped charge. Code development was concentrated on the PELE code, a multimaterial, multiphase, explicit finite-difference Eulerian code for pool suppression dynamics of a hypothetical loss-of-coolant accident in a nuclear reactor. Activities of the Fluid Dynamics Group were directed toward development of a code to compute the equations of state and transport properties of liquid metals (e.g. Li) and partially ionized dense plasmas, jet stability in the Li reactor system, and the study and problem application of fluid dynamic turbulence theory. 19 figures, 5 tables. (RWR)« less

CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production.

PubMed

Romagnani, Paola; Maggi, Laura; Mazzinghi, Benedetta; Cosmi, Lorenzo; Lasagni, Laura; Liotta, Francesco; Lazzeri, Elena; Angeli, Roberta; Rotondi, Mario; Filì, Lucia; Parronchi, Paola; Serio, Mario; Maggi, Enrico; Romagnani, Sergio; Annunziato, Francesco

2005-12-01

Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells. We sought to investigate the in vitro effects of CXCL10 and CXCL4 on the production of TH1 or TH2 cytokines. The cytokine profile of antigen-specific human CD4+ T-cell lines obtained in the absence or presence of CXCL10 or CXCL4 was evaluated by means of quantitative RT-PCR, flow cytometry, and ELISA. CXCL10 upregulated IFN-gamma and downregulated IL-4, IL-5, and IL-13 production, whereas CXCL4 downregulated IFN-gamma and upregulated TH2 cytokines. Similar effects were also observed on polyclonally activated pure naive CD4+ T cells. The opposite effects of CXCL10 and CXCL4 on TH1 and TH2 cytokine production were inhibited by an anti-CXCR3 antibody able to neutralize both CXCR3-A and CXCR3-B and were apparently related to the activation of distinct signal transduction pathways. Moreover, CXCL10 upregulated mRNA levels of T-box expressed in T cells and downregulated GATA-3 expression, whereas CXCL4 downregulated T-box expressed in T cells and upregulated GATA-3. Finally, CXCL4, but not CXCL10, induced direct activation of IL-5 and IL-13 promoters. CXCL10 and CXCL4 exert opposite effects on the production of human TH1 and TH2 cytokines, likely through their respective interaction with CXCR3-A or CXCR3-B and the consequent activation of different signal transduction pathways. This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy.

The Savannah River Site`s Groundwater Monitoring Program: Third quarter 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, C.D.

1993-02-04

The Environmental Protection Department/Environmental Monitoring Section (EPD/EMS) administers the Savannah River Site`s (SRS) Groundwater Monitoring Program. During third quarter 1992, EPD/EMS conducted extensive sampling of monitoring wells. Table 1 lists those well series with constituents in the groundwater above Flag 2 during third quarter 1992, organized by location. Results from all laboratory analyses are used to generate this table. Specific conductance and pH data from the field also are included in this table.

1. North side of quarters (executive officer's quarters), looking southeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. North side of quarters (executive officer's quarters), looking southeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

5. East side of quarters (executive officer's quarters), looking west ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. East side of quarters (executive officer's quarters), looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. West side of quarters (executive officer's quarters), looking east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. West side of quarters (executive officer's quarters), looking east - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

3. Southwest side of quarters (executive officer's quarters), looking northeast ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters (executive officer's quarters), looking northeast - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

PubMed Central

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y.; Serody, Jonathan S.; Chen, Xian; Xu, Xiaojiang; Wade, Paul A.; Cook, Donald N.; Ting, Jenny P.; Wan, Yisong Y.

2017-01-01

Th17 cells are critically involved in host defense, inflammation, and autoimmunity1–5. TGF-β is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed RORγt expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-β signaling in a RORγt-dependent manner. Ectopic Smad4 expression suppressed the RORγt expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-β neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-β stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-β-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of RORγt to license Th17 differentiation. This study reveals a critical mechanism by which TGF-β controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. PMID:29072299

3. Southwest side of quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Southwest side of quarters R (commanding officer's quarters), looking east - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

6. Interior of quarters (executive officer's quarters), living room, looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Interior of quarters (executive officer's quarters), living room, looking west - Naval Air Station Chase Field, Quarters S, Essex Street, .45 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

1. Northeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Northeast side of Quarters R (commanding officer's quarters), looking west - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

2. Southeast side of Quarters R (commanding officer's quarters), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Southeast side of Quarters R (commanding officer's quarters), looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Subjective depth of field in presence of 4th-order and 6th-order Zernike spherical aberration using adaptive optics technology.

PubMed

Benard, Yohann; Lopez-Gil, Norberto; Legras, Richard

2010-12-01

To study the impact on the subjective depth of field of 4th-order spherical aberration and its combination with 6th-order spherical aberration and analyze the accuracy of image-quality metrics in predicting the impact. Laboratoire Aimé Cotton, Centre National de la Recherche Scientifique, Université Paris-Sud, Orsay, France. Case series. Subjective depth of field was defined as the range of defocus at which the target (3 high-contrast letters at 20/50) was perceived acceptable. Depth of field was measured using 0.18 diopter (D) steps in young subjects with the addition of the following spherical aberration values: ±0.3 μm and ±0.6 μm 4th-order spherical aberration with 3.0 mm and 6.0 mm pupils and ±0.3 μm 4th-order spherical aberration with ±0.1 μm 6th-order spherical aberration for 6.0 mm pupils. The addition of ±0.3 and ±0.6 μm 4th-order spherical aberration increased depth of field by 30% and 45%, respectively. The combination of 4th-order spherical aberration and 6th-order spherical aberration of opposite signs increased depth of field more than 4th-order spherical aberration alone (ie, 63%), while the combination of 4th-order spherical aberration and 6th-order spherical aberration of the same signs did not (ie, 24%). Whereas the midpoint of the depth of field could be predicted by image-quality metrics, none was found a good predictor of objectionable depth of field. Subjective depth of field increased when 4th-order spherical aberration and 6th-order spherical aberration of opposite signs were added but could not be predicted with image-quality metrics. Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

5. Interior of Quarters R (commanding officer's quarters), living room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Interior of Quarters R (commanding officer's quarters), living room, looking northwest - Naval Air Station Chase Field, Quarters R, Essex Street, .43 mile South-Southeast of intersection of Texas State Highway 202 & Independence Street, Beeville, Bee County, TX

Trustee Quarterly; Volume 10, Numbers 1-4, 1985-86.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1986-01-01

These four issues of "ACCT Trustee Quarterly" contain articles on topics of current concern to community college trustees. The first issue contains articles on strategic long-range planning, successful chairman of the board techniques, linkages between community colleges and business and industry, board/president relations, performance appraisals…

Temperature-resolved study of three [M(M'O4)4(TBPO)4] complexes (MM' = URe, ThRe, ThTc).

PubMed

Helliwell, Madeleine; Collison, David; John, Gordon H; May, Iain; Sarsfield, Mark J; Sharrad, Clint A; Sutton, Andrew D

2006-02-01

The crystal structures of the title complexes were measured at several temperatures between room temperature and 100 K. Each sample shows reversible crystal-to-crystal phase transitions as the temperature is varied. The behaviour of [U(ReO4)4(TBPO)4] (I) and [Th(ReO4)4(TBPO)4] (II) (TBPO = tri-n-butylphosphine oxide) is very similar; at room temperature, crystals of (I) and (II) are isostructural, with space group I42m, and reducing the temperature to 100 K causes a lowering of the space-group symmetry to C-centred cells, space groups Cc for (I) and Cmc2(1) for (II). The variation of lattice symmetry of [Th(TcO4)4(TBPO)4] (III) was found to be somewhat different, with the body-centred cubic space group, I43m, occurring at 293 K, a reduction of symmetry at 230 K to the C-centred orthorhombic space group, Cmc2(1), and a further transition to the primitive orthorhombic space group, Pbc2(1), below 215 K. Elucidation of the correct space-group symmetry and the subsequent refinement was complicated in some cases by the twinning by pseudo-merohedry that arises from the lowering of the space-group symmetry, occurring as the temperature is reduced. All three of the crystal structures determined at room temperature have high atomic displacement parameters, particularly of the (n)Bu groups, and (III) shows disorder of some of the O atoms. The structures in the space group Cmc2(1), show some disorder of nBu groups, but are otherwise reasonably well ordered; the structures of (I) in Cc and (III) in Pbc2(1) are ordered, even to the ends of the alkyl chains. Inter-comparison of the structures measured below 293 K, using the program OFIT from the SHELXTL package, showed that generally, they are remarkably alike, with weighted r.m.s. deviations of the M, M' and P atoms of less than 0.1 A, as are the 293 K structures of (I) and (II) with their low-temperature counterparts. However, the structure of (III) measured in the space group Cmc2(1) is significantly different from both the

Applied Meteorology Unit (AMU) Quarterly Report First Quarter FY-04

NASA Technical Reports Server (NTRS)

Bauman, William; Wheeler, Mark; Labert, Winifred; Jonathan Case; Short, David

2004-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the First Quarter of Fiscal Year 2004 (October - December 2003). Tasks reviewed are: (1) Objective Lightning Probability Forecast, (2) Mesonet Temperature and Wind Climatology, (3) Severe Weather Forecast Decision Aid and (4) Anvil Transparency Relationship to Radar Reflectivity

Kinetics of Cathode Processes in Separation of Thorium from Molten Salts. Part I. Investigation of ThF$sub 4$ and ThF$sub 4$-CaF$sub 2$; KINETYKA PROCESU KATODOWEGO PRZY OSADZANIU TORU ZE STOPIONYCH SOLI. CZESC I. BADANIA ThF$sub 4$ I ThF$sub 4$-CaF$sub 2$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mints, S.; Rafal'skii, V.

1961-09-01

The current-intensity curves of non-electrolyzed salts and the curves of time-intensity and current-intensity in electrolyzed salts were plotted for molten ThF/sub 4/ and ThF /sub 4/CaF/sub 2/. The intensity of salt disintegration was determined, and electric conductivity in electrolyte was observed. (trauth)

A novel acute HIV infection staging system based on 4th generation immunoassay.

PubMed

Ananworanich, Jintanat; Fletcher, James L K; Pinyakorn, Suteeraporn; van Griensven, Frits; Vandergeeten, Claire; Schuetz, Alexandra; Pankam, Tippawan; Trichavaroj, Rapee; Akapirat, Siriwat; Chomchey, Nitiya; Phanuphak, Praphan; Chomont, Nicolas; Michael, Nelson L; Kim, Jerome H; de Souza, Mark

2013-05-29

Fourth generation (4thG) immunoassay (IA) is becoming the standard HIV screening method but was not available when the Fiebig acute HIV infection (AHI) staging system was proposed. Here we evaluated AHI staging based on a 4thG IA (4thG staging). Screening for AHI was performed in real-time by pooled nucleic acid testing (NAT, n=48,828 samples) and sequential enzyme immunoassay (EIA, n=3,939 samples) identifying 63 subjects with non-reactive 2nd generation EIA (Fiebig stages I (n=25), II (n=7), III (n=29), IV (n=2)). The majority of samples tested (n=53) were subtype CRF_01AE (77%). NAT+ subjects were re-staged into three 4thG stages: stage 1 (n=20; 4th gen EIA-, 3rd gen EIA-), stage 2 (n=12; 4th gen EIA+, 3rd gen EIA-), stage 3 (n=31; 4th gen EIA+, 3rd gen EIA+, Western blot-/indeterminate). 4thG staging distinguishes groups of AHI subjects by time since presumed HIV exposure, pattern of CD8+ T, B and natural killer cell absolute numbers, and HIV RNA and DNA levels. This staging system further stratified Fiebig I subjects: 18 subjects in 4thG stage 1 had lower HIV RNA and DNA levels than 7 subjects in 4thG stage 2. Using 4th generation IA as part of AHI staging distinguishes groups of patients by time since exposure to HIV, lymphocyte numbers and HIV viral burden. It identifies two groups of Fiebig stage I subjects who display different levels of HIV RNA and DNA, which may have implication for HIV cure. 4th generation IA should be incorporated into AHI staging systems.

9 CFR 391.4 - Laboratory services rate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Laboratory services rate. 391.4 Section 391.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FEES AND CHARGES FOR INSPECTION SERVICES AND LABORATORY ACCREDITATION § 391.4 Laboratory...

Science Books: A Quarterly Review, Volume 8, Number 4.

ERIC Educational Resources Information Center

American Association for the Advancement of Science, Washington, DC.

This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in kindergartens, elementary schools, secondary schools, and in the first two years of college. Also included are selected advanced and professional books useful for reference by students and faculty members. Annotations are…

The AMTEX Partnership{sup trademark}. Second quarter report. Fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemon, D.K.; Quisenberry, R.K.

1996-03-01

This quarterly report details activities of the AMTEX Partnership {sup TM} which is a collaborative research and development program among the U.S. Integrated Textile Industry, the Department of Energy (DOE), the national laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating U.S. jobs.

Promoting Maternal and Infant Health in the 4th Trimester

ERIC Educational Resources Information Center

Verbiest, Sarah B.; Tully, Kristin P.; Stuebe, Alison M.

2017-01-01

The "4th trimester" refers to the transition period after childbirth when infants are adjusting to life outside the womb and mothers are adjusting to new parenthood. This critical period is marked by significant biological, psychological, and social changes, which are currently insufficiently supported. The 4th trimester perspective…

Science Books, A Quarterly Review, Volume 6 Number 4.

ERIC Educational Resources Information Center

Deason, Hilary J.

1971-01-01

For the improvement of science education and to facilitate the public understanding of science, the American Association for the Advancement of Science publishes this quarterly review of science books. Evaluations and annotations are given for trade books, textbooks, and reference works in the pure and applied sciences. Books are for students in…

Science Books, A Quarterly Review, Volume 7 Number 4.

ERIC Educational Resources Information Center

American Association for the Advancement of Science, Washington, DC.

"Science Books" is published quarterly to review trade books, textbooks, and reference works in the pure and applied sciences for students in the elementary school, secondary school, and first two years of college. It includes selected advanced and professional books useful for reference by students and faculty members. The approximately 200…

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2013 CFR

2013-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2011 CFR

2011-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2012 CFR

2012-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2014 CFR

2014-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

12 CFR 1410.3 - Calculation and reporting of premiums due.

Code of Federal Regulations, 2010 CFR

2010-01-01

... September 30, 2008) and the premium payment for the 4th Quarter 2008 (defined for purposes of this section... this section) to the insured bank during the 3rd Quarter 2008 or 4th Quarter 2008, respectively. (2) In... premium payment for the 4th Quarter 2008 (having been reduced by the Corporation acting under section 5.55...

Viability of bovine demi- and quarter-embryos after transfer.

PubMed

Bredbacka, P; Huhtinen, M; Aalto, J; Rainio, V

1992-07-01

The viability of bovine demi- and quarter-embryos was investigated. Early compacting morulae were nonsurgically flushed from superovulated donor cows and were bisected by two microneedles. One of the halves was then split further into two quarters. Each demi- and quarter-embryo was placed in an evacuated zona pellucida. One demi- or two quarter-embryos were transferred non-surgically into cow or heifer recipients. Viability was measured by ultrasound scanning of the fetuses on Days 35, 48 and 60 of pregnancy. The pregnancy rates at Day 60 were 46.2% (6/13) for heifers and 33.3% (4/12) for cows after the transfer of a single demi-embryo. The transfer of two quarter-embryos resulted in a pregnancy rate of 61.5% (8/13) for heifers and 8.3% (1/12) for cows. Seven (53.8%) and four (33.3%) live fetuses were found on Day 60 following the transfer of demi-embryos into heifers and cows, respectively. The transfer of quarter-embryos resulted in 10 fetuses (38.5%) in the heifer recipients and only one fetus (4.2%) in the cow recipients. The results of this study suggest that heifers are more suitable than cows as recipients for quarter-embryos.

Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays.

PubMed

Keen, P; Conway, D P; Cunningham, P; McNulty, A; Couldwell, D L; Davies, S C; Smith, D E; Gray, J; Holt, M; O'Connor, C C; Read, P; Callander, D; Prestage, G; Guy, R

2017-01-01

The Trinity Biotech Uni-Gold HIV test (Uni-Gold) is often used as a supplementary rapid test in testing algorithms. To evaluate the operational performance of the Uni-Gold as a first-line screening test among gay and bisexual men (GBM) in a setting where 4th generation HIV laboratory assays are routinely used. We compared the performance of Uni-Gold with conventional HIV serology conducted in parallel among GBM attending 22 testing sites. Sensitivity was calculated separately for acute and established infection, defined using 4th generation screening Ag/Ab immunoassay (EIA) and Western blot results. Previous HIV testing history and results of supplementary 3rd generation HIV Ab EIA, and p24 antigen EIA were used to further characterise cases of acute infection. Of 10,793 specimens tested with Uni-Gold and conventional serology, 94 (0.90%, 95%CI:0.70-1.07) were confirmed as HIV-positive by conventional serology, and 37 (39.4%) were classified as acute infection. Uni-Gold sensitivity was 81.9% overall (77/94, 95%CI:72.6-89.1); 56.8% for acute infection (21/37, 95%CI:39.5-72.9) and 98.2% for established infection (56/57, 95%CI:90.6-100.0). Of 17 false non-reactive Uni-Gold results, 16 were acute infections, and of these seven were p24 antigen reactive but antibody negative. Uni-Gold specificity was 99.9% (10,692/10,699, 95%CI:99.9-100.0), PPV was 91.7% (95%CI:83.6-96.6) and NPV was 99.8% (95%CI:99.7-99.9), respectively. In this population, Uni-Gold had good specificity and sensitivity was high for established infections when compared to 4th generation laboratory assays, however sensitivity was lower in acute infections. Where rapid tests are used in populations with a high proportion of acute infections, additional testing strategies are needed to detect acute infections. Copyright © 2016 Elsevier B.V. All rights reserved.

The 1992 4th NASA SERC Symposium on VLSI Design

NASA Technical Reports Server (NTRS)

Whitaker, Sterling R.

1992-01-01

Papers from the fourth annual NASA Symposium on VLSI Design, co-sponsored by the IEEE, are presented. Each year this symposium is organized by the NASA Space Engineering Research Center (SERC) at the University of Idaho and is held in conjunction with a quarterly meeting of the NASA Data System Technology Working Group (DSTWG). One task of the DSTWG is to develop new electronic technologies that will meet next generation electronic data system needs. The symposium provides insights into developments in VLSI and digital systems which can be used to increase data systems performance. The NASA SERC is proud to offer, at its fourth symposium on VLSI design, presentations by an outstanding set of individuals from national laboratories, the electronics industry, and universities. These speakers share insights into next generation advances that will serve as a basis for future VLSI design.

International Space Station USOS Crew Quarters Development

NASA Technical Reports Server (NTRS)

Broyan, James Lee, Jr.; Borrego, Melissa Ann; Bahr, Juergen F.

2008-01-01

The International Space Station (ISS) United States Operational Segment (USOS) currently provides a Temporary Sleep Station (TeSS) as crew quarters for one crewmember in the Laboratory Module. The Russian Segment provides permanent crew quarters (Kayutas) for two crewmembers in the Service Module. The TeSS provides limited electrical, communication, and ventilation functionality. A new permanent rack sized USOS ISS Crew Quarters (CQ) is being developed. Up to four CQs can be installed into the Node 2 element to increase the ISS crewmember size to six. The new CQs will provide private crewmember space with enhanced acoustic noise mitigation, integrated radiation reduction material, controllable airflow, communication equipment, redundant electrical systems, and redundant caution and warning systems. The rack sized CQ is a system with multiple crewmember restraints, adjustable lighting, controllable ventilation, and interfaces that allow each crewmember to personalize their CQ workspace. Providing an acoustically quiet and visually isolated environment, while ensuring crewmember safety, is critical for obtaining crewmember rest and comfort to enable long term crewmember performance. The numerous human factor, engineering, and program considerations during the concept, design, and prototyping are outlined in the paper.

[The comparison of 4th, 5th and 6th year medical students knowledge of rules and practical skills in the interpretation of electrocardiograms at Jagiellonian University].

PubMed

Pudło, Joanna; Wierdak, Mateusz; Macioł, Karolina; Gumul, Katarzyna; Lelakowski, Jacek

2012-01-01

The electrocardiogram (ECG) examination is one of the most frequent administered diagnostic tests. It is commonly ordered by General Practitioners, and it has became a routinely administered examination during admission to the hospital. During their studies, medical students has numerous opportunities to review and interpret the results of these tests. The aim of our research was to statistically compare and contrast the knowledge of the rules and practical skills in the interpretation of ECGs in 4th, 5th and 6th year medical students at Jagiellonian University. We wanted to better define in which year the students acquire the most of their clinical skills and determine if 6th year students have sufficient knowledge and skills to adequately perform in their future career. We additionally wanted to understand from which source students draw their knowledge of the ECG. The population of 249- 4th, 5th and 6th year medical students of Jagiellonian University were asked to reply to an anonymous questionnaire. The questionnaire was comprised of three parts. The fist part contains four simple ECGs (STEMI, RBBB, PVC, normogram--sinus rhythm). The second part contained six questions regarding their theoretical knowledge. The third part contained seven questions which evaluated the students' background and approach to the problem. Students filled the questionnaire without prior preparation to avoid the short-term "examination knowledge". The question that was most frequent answered correctly was question regarding the proper time (in milliseconds) of QRS complex (24.1%). Differences in the percentage of correct answers to questionnaire amongst 4th and 5th year students were statistically uncharacteristic. The percentage of correct answers of 6th year students increased by about 16% (p < 0.0001). The comparison of answers between 6th year students - who in prior semester completed a cardiology course (group A 6th year) and 6th year students who did not yet complete cardiology

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

PubMed Central

Janosko, Krisztina; Holbrook, Michael R.; Adams, Ricky; Barr, Jason; Bollinger, Laura; Newton, Je T'aime; Ntiforo, Corrie; Coe, Linda; Wada, Jiro; Pusl, Daniela; Jahrling, Peter B.; Kuhn, Jens H.; Lackemeyer, Matthew G.

2016-01-01

Biosafety level 4 (BSL-4) suit laboratories are specifically designed to study high-consequence pathogens for which neither infection prophylaxes nor treatment options exist. The hallmarks of these laboratories are: custom-designed airtight doors, dedicated supply and exhaust airflow systems, a negative-pressure environment, and mandatory use of positive-pressure (“space”) suits. The risk for laboratory specialists working with highly pathogenic agents is minimized through rigorous training and adherence to stringent safety protocols and standard operating procedures. Researchers perform the majority of their work in BSL-2 laboratories and switch to BSL-4 suit laboratories when work with a high-consequence pathogen is required. Collaborators and scientists considering BSL-4 projects should be aware of the challenges associated with BSL-4 research both in terms of experimental technical limitations in BSL-4 laboratory space and the increased duration of such experiments. Tasks such as entering and exiting the BSL-4 suit laboratories are considerably more complex and time-consuming compared to BSL-2 and BSL-3 laboratories. The focus of this particular article is to address basic biosafety concerns and describe the entrance and exit procedures for the BSL-4 laboratory at the NIH/NIAID Integrated Research Facility at Fort Detrick. Such procedures include checking external systems that support the BSL-4 laboratory, and inspecting and donning positive-pressure suits, entering the laboratory, moving through air pressure-resistant doors, and connecting to air-supply hoses. We will also discuss moving within and exiting the BSL-4 suit laboratories, including using the chemical shower and removing and storing positive-pressure suits. PMID:27768063

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures.

PubMed

Janosko, Krisztina; Holbrook, Michael R; Adams, Ricky; Barr, Jason; Bollinger, Laura; Newton, Je T'aime; Ntiforo, Corrie; Coe, Linda; Wada, Jiro; Pusl, Daniela; Jahrling, Peter B; Kuhn, Jens H; Lackemeyer, Matthew G

2016-10-03

Biosafety level 4 (BSL-4) suit laboratories are specifically designed to study high-consequence pathogens for which neither infection prophylaxes nor treatment options exist. The hallmarks of these laboratories are: custom-designed airtight doors, dedicated supply and exhaust airflow systems, a negative-pressure environment, and mandatory use of positive-pressure ("space") suits. The risk for laboratory specialists working with highly pathogenic agents is minimized through rigorous training and adherence to stringent safety protocols and standard operating procedures. Researchers perform the majority of their work in BSL-2 laboratories and switch to BSL-4 suit laboratories when work with a high-consequence pathogen is required. Collaborators and scientists considering BSL-4 projects should be aware of the challenges associated with BSL-4 research both in terms of experimental technical limitations in BSL-4 laboratory space and the increased duration of such experiments. Tasks such as entering and exiting the BSL-4 suit laboratories are considerably more complex and time-consuming compared to BSL-2 and BSL-3 laboratories. The focus of this particular article is to address basic biosafety concerns and describe the entrance and exit procedures for the BSL-4 laboratory at the NIH/NIAID Integrated Research Facility at Fort Detrick. Such procedures include checking external systems that support the BSL-4 laboratory, and inspecting and donning positive-pressure suits, entering the laboratory, moving through air pressure-resistant doors, and connecting to air-supply hoses. We will also discuss moving within and exiting the BSL-4 suit laboratories, including using the chemical shower and removing and storing positive-pressure suits.

Different modulation by histamine of IL-4 and interferon-gamma (IFN-γ) release according to the phenotype of human Th0, Th1 and Th2 clones

PubMed Central

LAGIER, B; LEBEL, B; BOUSQUET, J; PÈNE, J

1997-01-01

Histamine, an important inflammatory mediator in allergic diseases and asthma, has been reported to have modulator effects on T cells, suggesting that the bronchial microenvironment may regulate the function of resident T cells. We examined the effect of histamine on the release of the Th2-associated cytokines IL-4 and IL-5 and the Th1-associated cytokine IFN-γ by 30 CD4+ T cell clones from peripheral blood or bronchial biopsy of one atopic subject. Based on the IL-4/IFN-γ ratio, the clones were ascribed to the Th2 (ratio >1), Th0 (ratio ⩾ 0.1 and ⩽1) or Th1 (ratio <0.1) phenotype. Histamine inhibited IFN-γ production by Th1-like cells (P<0.02, Kruskall–Wallis), especially from bronchial biopsy, but had no effect on IL-4 release. Regarding Th0 clones, histamine inhibited IL-4 production (P<0.02) in a dose-dependent manner and slightly inhibited IFN-γ production, but had no effect on Th2-like cells. Histamine had a heterogeneous and insignificant effect on IL-5 production. The H2-receptor antagonist ranitidine completely reversed the inhibition of IL-4 and IFN-γ production, whereas the agonist dimaprit mimicked this effect. In contrast, H1- and H3-receptor agonists and antagonists had no significant effect. These data demonstrate that histamine has different effects on IL-4 and IFN-γ release by T helper cells according to their phenotype via H2-receptors. This study extends the immunomodulatory effects of histamine which may contribute to the perpetuation of airway inflammation in asthma. PMID:9182905

Comparison of Visual Assessment of Breast Density in BI-RADS 4th and 5th Editions With Automated Volumetric Measurement.

PubMed

Youk, Ji Hyun; Kim, So Jung; Son, Eun Ju; Gweon, Hye Mi; Kim, Jeong-Ah

2017-09-01

The purpose of this study was to compare visual assessments of mammographic breast density by radiologists using BI-RADS 4th and 5th editions in correlation with automated volumetric breast density measurements. A total of 337 consecutive full-field digital mammographic examinations with standard views were retrospectively assessed by two radiologists for mammographic breast density according to BI-RADS 4th and 5th editions. Fully automated measurement of the volume of fibroglandular tissue and total breast and percentage breast density was performed with a commercially available software program. Interobserver and intraobserver agreement was assessed with kappa statistics. The distributions of breast density categories for both editions of BI-RADS were compared and correlated with volumetric data. Interobserver agreement on breast density category was moderate to substantial (κ = 0.58-0.63) with use of BI-RADS 4th edition and substantial (κ = 0.63-0.66) with use of the 5th edition but without significant difference between the two editions. For intraobserver agreement between the two editions, the distributions of density category were significantly different (p < 0.0001), the proportions of dense breast increased, and the proportion of fatty breast decreased with use of the 5th edition compared with the 4th edition (p < 0.0001). All volumetric breast density data, including percentage breast density, were significantly different among density categories (p < 0.0001) and had significant correlation with visual assessment for both editions of BI-RADS (p < 0.01). Assessment using BI-RADS 5th edition revealed a higher proportion of dense breast than assessment using BI-RADS 4th edition. Nevertheless, automated volumetric density assessment had good correlation with visual assessment for both editions of BI-RADS.

Safety in the Chemical Laboratory: An Undergraduate Chemical Laboratory Safety Course.

ERIC Educational Resources Information Center

Nicholls, L. Jewel

1982-01-01

Describes a two-quarter hour college chemistry course focusing on laboratory safety. Includes lists of topics/assignments, problem sets (toxicology, storage, and energy) and videotapes, films, and slide sets used in the course. (JN)

Successful 4th kidney transplantation: a case report from Iran.

PubMed

Nourbala, Mohammad Hossein; Ghadian, Alireza; Einollahi, Behzad; Azarabadi, Mehdi

2013-05-21

Kidney transplantation is generally considered the best option for most patients with end-stage renal disease requiring renal replacement therapy, even for patients with graft failure. Here, we describe a case of a 49-year-old man who received his 1st kidney transplant the United Kingdom from his brother when he was 18 years old in. Thirty-one year after the first transplant, he underwent successful 4th living-unrelated kidney transplantation with no serious complications at our transplant center. He continued to have excellent allograft function and his latest serum creatinine 33 months after his 4th transplant was 1.2 mg/dL. To our knowledge, this is the first case of 4th kidney transplantation from Iran.

Accidental fires in clinical laboratories.

PubMed

Hoeltge, G A; Miller, A; Klein, B R; Hamlin, W B

1993-12-01

The National Fire Protection Association, Quincy, Mass, estimates that 169 fires have occurred annually in health care, medical, and chemical laboratories. On the average, there are 13 civilian injuries and $1.5 million per year in direct property damage. Most fires in which the cause or ignition source can be identified originate in malfunctioning electrical equipment (41.6%) or in the facility's electrical distribution system (14.7%). The prevalence of fire safety deficiencies was measured in the College of American Pathologists Laboratory Accreditation Program. Of the 1732 inspected laboratories, 5.5% lacked records of electrical receptacle polarity and ground checks in the preceding year. Of these inspected laboratories, 4.7% had no or incomplete documentation of electrical safety checks on laboratory instruments. There was no evidence of quarterly fire exit drills in 9% of the laboratories. Deficiencies were also found in precautionary labeling (6.8%), in periodic review of safe work practices (4.2%), in the use of safety cans (3.7%), and in venting of flammable liquid storage areas (2.8%). Fire preparedness would be improved if all clinical laboratories had smoke detectors and automatic fire-extinguishing systems. In-service training courses in fire safety should be targeted to the needs of specific service areas.

Relationships between Grade Levels, Personal Factors, and Instructional Variation among 4th-12th Grade Teachers

ERIC Educational Resources Information Center

White, Jacquelyn M.

2011-01-01

The purpose of this quantitative correlational study was to investigate relationships between grade levels, personal factors of teachers, and instructional variety used by 4th-12th grade teachers in Kern County, California. The population under investigation included 2,844 teachers. 235 elementary, middle school/junior high, and secondary teachers…

ACCT Trustee Quarterly; Volume 8, Numbers 1-4, 1983-1984.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1984-01-01

These four issues of "ACCT Trustee Quarterly" contain articles on topics of current concern to community college trustees. The first issue contains articles on high technology, humanistic management, a legislative history of the "Apple" Bill, trustee-president relations, educational quality, part-time instructors, and health promotion through…

75 FR 34636 - Safety Zone; Jameson Beach 4th of July Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

...-AA00 Safety Zone; Jameson Beach 4th of July Fireworks Display AGENCY: Coast Guard, DHS. ACTION... waters of Lake Tahoe, for the Jameson Beach 4th of July Fireworks Display. This safety zone is... Safety Zone; Jameson Beach 4th of July Fireworks Display. (a) Location. This temporary safety zone is...

4TH Marine Division Operation Plan Number 49-44

DTIC Science & Technology

1944-12-26

information if it does not display a currently valid OMB control number. 1. REPORT DATE MAY 1972 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND...assigned (Annex DOG to Adm 0 No. ;44-44,. (2) 4th Tk Bn (less Cos A, B, & C), on landing, be prepared to assume control of Tk Elms as released and Spt...the Atk. (3) 41th Ned Bn, on landing Bn Ho and on Div order, assume control of Cos A, B, and C ashore, prepared to land the remainder of the Bn on Div

EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

2009-02-02

The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

Disinfection in the laboratory: theory and practice in disinfection policy in late C19th and early C20th England.

PubMed

Whyte, Rebecca

2015-03-01

This article examines the relationship between theory and practice in nineteenth century English public health disinfection practice. Disinfection undertaken by local authorities and practised on objects, spaces and people became an increasingly common public health practice in the last quarter of the nineteenth century, and was part of a newly developed public health system of 'stamping out' disease as described by Hardy. Despite disinfection's key role in public health policy, it has thus far not received significant investigation or historiographical attending. This article explores the development of disinfection policy at local level, highlighting that despite commentators assumptions that increasingly exacting standards of disinfection required professional oversight rather than that of the 'amateur' public, there was a significant gap between laboratory based knowledge and evidence derived from practical experience. Laboratory conditions could not replicate those found in day-to-day disinfection, and there were myriad debates about how to create a mutually understandable scientific standard for testing. Despite increasing efforts to bring local disinfection in line with new ideas promulgated by central government and disinfection researchers, the mismatches between the two meant that there was greater divergence. This tension lay at the heart of the changes in disinfection theory and practice in the second half of the nineteenth century, and illustrate the complexities of the impact of germ theory on public health policy. Copyright © 2015 Elsevier Ltd. All rights reserved.

Implementing a laboratory automation system: experience of a large clinical laboratory.

PubMed

Lam, Choong Weng; Jacob, Edward

2012-02-01

Laboratories today face increasing pressure to automate their operations as they are challenged by a continuing increase in workload, need to reduce expenditure, and difficulties in recruitment of experienced technical staff. Was the implementation of a laboratory automation system (LAS) in the Clinical Biochemistry Laboratory at Singapore General Hospital successful? There is no simple answer, so the following topics comparing and contrasting pre- and post-LAS have been explored: turnaround time (TAT), laboratory errors, and staff satisfaction. The benefits and limitations of LAS from the laboratory experience were also reviewed. The mean TAT for both stat and routine samples decreased post-LAS (30% and 13.4%, respectively). In the 90th percentile TAT chart, a 29% reduction was seen in the processing of stat samples on the LAS. However, no significant difference in the 90th percentile TAT was observed with routine samples. It was surprising to note that laboratory errors increased post-LAS. Considerable effort was needed to overcome the initial difficulties associated with adjusting to a new system, new software, and new working procedures. Although some of the known advantages and limitations of LAS have been validated, the claimed benefits such as improvements in TAT, laboratory errors, and staff morale were not evident in the initial months.

The AMTEX Partnership{trademark}. First quarter report, Fiscal year 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-12-01

The AMTEX Partnership is a collaborative research and development program among the US Integrated Textile Industry, DOE, the National Laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating US jobs. Topics in this quarters report include: computer-aided fabric evaluation, cotton biotechnology, demand activated manufacturing architecture, electronic embedded fingerprints, on-line process control in flexible fiber manufacturing, rapid cutting, sensors for agile manufacturing, and textile resource conservation.

Strategic Studies Quarterly. Volume 6, Number 4, Winter 2012

DTIC Science & Technology

2012-01-01

surfaced in Australia, where a disgruntled employee rigged a computerized control system at a water treatment plant and...strategy" refers to a multilinear whole-of-government method geared to overcome the resistance and effects of a rival’s A2/AD strategy. r * Anti-Access...counterspace tech- nologies, and long-range surface -to-air missiles. To a force that intends to [44] STRATEGIC STUDIES QUARTERLY ♦ WINTER 2012

Acquisition Review Quarterly: Vol. 4, No. 2, Spring 1997

DTIC Science & Technology

1997-01-01

universities including the University of Southern California, the University of Chicago, George Mason Uni- versity, and the George Washington University...of competition in its were master’s theses from the Air Force analysis. Institute of Technology. Greer and Liao (1983) investigated con- Brost (1982...Postgradu- The Quarterly Journal of Economics, ate School, Monterey, CA, September. 681-707. Brost , E. J. (1982, September). A compara- Beltramo. M. N

ACCT Trustee Quarterly; Volume 9, Numbers 1-4, 1984-1985.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1985-01-01

These four issues of "ACCT Trustee Quarterly" contain articles on topics of current concern to community college trustees. The first issue contains the report of the Ad Hoc Committee on Excellence in Education of the Illinois Community College Trustees Association, and articles on merit pay in higher education, underrepresentation of…

ACCT Trustee Quarterly; Volume 7, Numbers 1-4, 1982-1983.

ERIC Educational Resources Information Center

Hutchins, Sally, Ed.

1983-01-01

These four issues of "ACCT Trustee Quarterly" contain articles on topics of current concern to community college trustees. Issue 1, a special issue, focuses on community college relations with the state and federal governments, providing articles on the need for a national employment policy, liaison with Congress, restoring local control, the…

Early Fuel Cell Market Deployments: ARRA and Combined (IAA, DLA, ARRA): Quarter 4 2013 Composite Data Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurtz, J.; Sprik, S.

2014-06-01

This report includes the composite data products (CDPs) for early fuel cell market deployments in quarter 4 of 2013. Results are presented for ARRA (projects funded by the American Recovery and Reinvestment Act of 2009 [ARRA]) and Combined (projects funded by DOE Interagency Agreements [IAA], Department of Defense Defense Logistics Agency [DLA], and ARRA).

Test Collection Bulletin. A Quarterly Digest of Information on Tests. Vol. 10, Nos. 1, 2, 3, and 4.

ERIC Educational Resources Information Center

Rosen, Pamela, Ed.

These quarterly bulletins provide brief annotations of tests recently acquired by the Educational Testing Service Test Collection. The tests are grouped into these categories: (1) achievement, (2) aptitude, (3) personality, interest, attitudes, and opinions, (4) sensory-motor and miscellaneous. Entries of particular interest to those working with…

Residential Group Care Quarterly. Volume 7, Number 4, Spring 2007

ERIC Educational Resources Information Center

Shenk, Emily, Ed.

2007-01-01

"Residential Group Care Quarterly" is published four times a year by the Child Welfare League of America (CWLA). The Child Welfare League of America is the nation's oldest and largest membership-based child welfare organization. It is committed to engaging people everywhere in promoting the wellbeing of children, youth, and their families, and…

76 FR 37649 - Safety Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display AGENCY: Coast Guard, DHS... annual July 4th Fireworks Display (Tahoe City 4th of July Fireworks Display). This action is necessary to... INFORMATION: The Coast Guard will enforce the safety zone for the annual Tahoe City 4th of July Fireworks in...

Environmental Restoration (ER) Consolidated Quarterly Report_April to June 2017_ October 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2017-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the April, May, and June 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwatermore » [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III.« less

Effectiveness of oxfendazole against early and later 4th-stage Strongylus vulgaris in ponies.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P; Ducharme, N G; Baird, J D

1986-03-01

Twenty pony foals (reared worm free), 6.5 to 10 weeks of age, were inoculated with Strongylus vulgaris and allocated to 5 groups, each with 4 foals. One week after inoculation, 1 group of 4 foals was given oxfendazole (OFZ) at a dosage rate of 10 mg/kg of body weight, another group was given 2 such treatments 48 hours apart, and a 3rd group was given a placebo. All treatments were administered by stomach tube. Three weeks later, foals were euthanatized and necropsied in a test for efficacy against early 4th-stage larvae. Oxfendazole was 80% and 94.9% effective against early 4th-stage S vulgaris with 1 and 2 doses, respectively. A 4th group of 4 foals was given 2 treatments of OFZ, 48 hours apart, about 8 weeks after inoculation, and a 5th group was given a placebo. These foals were euthanatized and necropsied 5 weeks after treatment in a test for efficacy against later 4th-stage larvae. Two doses of OFZ were 96.6% effective against later 4th-stage larvae.

Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.

PubMed

Wu, Lin; Pan, Lifeng; Wei, Zhiyi; Zhang, Mingjie

2011-02-11

The unconventional myosin VIIa (MYO7A) is one of the five proteins that form a network of complexes involved in formation of stereocilia. Defects in these proteins cause syndromic deaf-blindness in humans [Usher syndrome I (USH1)]. Many disease-causing mutations occur in myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail that binds to another USH1 protein, Sans. We report the crystal structure of MYO7A MyTH4-FERM domains in complex with the central domain (CEN) of Sans at 2.8 angstrom resolution. The MyTH4 and FERM domains form an integral structural and functional supramodule binding to two highly conserved segments (CEN1 and 2) of Sans. The MyTH4-FERM/CEN complex structure provides mechanistic explanations for known deafness-causing mutations in MYO7A MyTH4-FERM. The structure will also facilitate mechanistic and functional studies of MyTH4-FERM domains in other myosins.

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-04

NASA Technical Reports Server (NTRS)

Bauman, William; Wheeler, Mark; Lambert, Winifred; Case, Jonathan; Short, David

2004-01-01

This report summarizes the Applied Meteorology Unit (A MU) activities for the fourth quarter of Fiscal Year 2004 (July -Sept 2004). Tasks covered are: (1) Objective Lightning Probability Forecast: Phase I, (2) Severe Weather Forecast Decision Aid, (3) Hail Index, (4) Shuttle Ascent Camera Cloud Obstruction Forecast, (5) Advanced Regional Prediction System (ARPS) Optimization and Training Extension and (5) User Control Interface for ARPS Data Analysis System (ADAS) Data Ingest.

Pathogen group specific risk factors for clinical mastitis, intramammary infection and blind quarters at the herd, cow and quarter level in smallholder dairy farms in Jimma, Ethiopia.

PubMed

Tolosa, T; Verbeke, J; Ayana, Z; Piepers, S; Supré, K; De Vliegher, S

2015-07-01

A cross-sectional study on clinical mastitis, intramammary infection (IMI) and blind quarters was conducted on 50 smallholder dairy farms in Jimma, Ethiopia. A questionnaire was performed, and quarters of 211 cows were sampled and bacteriologically cultured. Risk factors at the herd, cow, and quarter level for clinical mastitis and (pathogen-specific) intramammary infection were studied using multilevel modeling. As well, factors associated with quarters being blind were studied. Eleven percent of the cows and 4% of the quarters had clinical mastitis whereas 85% of the cows and 51% of the quarters were infected. Eighteen percent of the cows had one or more blind quarter(s), whereas 6% of the quarters was blind. Non-aureus staphylococci were the most frequently isolated pathogens in both clinical mastitis cases and IMI. The odds of clinical mastitis was lower in herds where heifers were purchased in the last year [odds ratio (OR) with 95% confidence interval: 0.11 (0.01-0.90)], old cows (>4 years) [OR: 0.45 (0.18-1.14)], and quarters not showing teat injury [OR: 0.23 (0.07-0.77)]. The odds of IMI caused by any pathogen was higher in herds not practicing teat drying before milking (opposed to drying teats with 1 towel per cow) [OR: 1.68 (1.05-2.69)], cows in later lactation (>180 DIM opposed to ≤90 DIM) [OR: 1.81 (1.14-2.88)], cows with a high (>3) body condition score (BCS) [OR: 1.57 (1.06-2.31)], right quarters (opposed to a left quarter position) [OR: 1.47 (1.10-1.98)], and quarters showing teat injury [OR: 2.30 (0.97-5.43)]. Quarters of cows in herds practicing bucket-fed calf feeding (opposed to suckling) had higher odds of IMI caused by Staphylococcus aureus [OR: 6.05 (1.31-27.90)]. Except for BCS, IMI caused by non-aureus staphylococci was associated with the same risk factors as IMI caused by any pathogen. No access to feed and water immediately after milking [OR: 2.41 (1.26-4.60)], higher parity [OR: 3.60 (1.20-10.82)] and tick infestation [OR: 2.42 (1

75 FR 34639 - Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

...-AA00 Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA AGENCY: Coast Guard... Cockrell's Creek in the vicinity of Reedville, Virginia in support of the Reedville July 4th Celebration... notice of proposed rulemaking (NPRM) entitled Reedville July 4th Celebration, Cockrell's Creek, Reedville...

76 FR 60805 - Quarterly Update to Annual Listing of Foreign Government Subsidies on Articles of Cheese Subject...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... DEPARTMENT OF COMMERCE International Trade Administration Quarterly Update to Annual Listing of... Administration, International Trade Administration, Department of Commerce. DATES: Effective Date: September 30... Administration, International Trade Administration, U.S. Department of Commerce, 14th Street and Constitution Ave...

4. LOOKING NORTHEAST TOWARDS LOCKS. 19TH CENTURY GRAVITY LOCKS ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. LOOKING NORTHEAST TOWARDS LOCKS. 19TH CENTURY GRAVITY LOCKS ON RIGHT. 20TH CENTURY ELECTRIC LIFT LOCKS ON LEFT. - New York State Barge Canal, Lockport Locks, Richmond Avenue, Lockport, Niagara County, NY

18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

75 FR 17699 - Quarterly Update to Annual Listing of Foreign Government Subsidies on Articles of Cheese Subject...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... DEPARTMENT OF COMMERCE International Trade Administration Quarterly Update to Annual Listing of... Administration, International Trade Administration, Department of Commerce. EFFECTIVE DATE: April 7, 2010. FOR..., International Trade Administration, U.S. Department of Commerce, 14th Street and Constitution Ave., NW...

75 FR 26157 - Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

...-AA00 Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA AGENCY: Coast Guard... Reedville July 4th Celebration event. This action is intended to restrict vessel traffic movement on... established in the interest of public safety during the Reedville July 4th Celebration event and will be...

Color duplex assessment of 4th and 5th internal mammary artery perforators: the pedicles of the medially based lower pole breast flaps.

PubMed

Abdel-Monem, Kareem; Elshahat, Ahmed; Abou-Gamrah, Sherif; Eldin Abol-Atta, Hossam; Abd Eltawab, Reda; Massoud, Karim

2012-01-01

Reconstruction of a breast after mastectomy using the contralateral lower pole breast flap is an appealing procedure because it uses the tissues that were going to be excised during reduction of the sound breast to achieve symmetry. Literature mentioned that these flaps are supplied by the lower internal mammary artery perforators (IMAPs) with no further details. The aim of this study was to determine the site, size, and number of the 4th and 5th IMAPs by using preoperative color Duplex ultrasound and intraoperative exploration. Twenty breasts in 10 patients who presented for reduction mammoplasty were included in this study. Preoperative color duplex was used to determine IMAPs in the 4th and 5th intercostal spaces. These perforators were localized intraoperatively. Intravenous fluorescein injection was used to determine the perfusion of the lower pole breast flap on the basis of these perforators. Statistically, the 4th IMAPs diameters were significantly larger than the 5th IMAPs diameters (P < .05). The lower pole breast flap was perfused through these perforators. Color Duplex ultrasound is an accurate tool to preoperatively determine the 4th and 5th IMAPs.

Color Duplex Assessment of 4th and 5th Internal Mammary Artery Perforators: The Pedicles of the Medially Based Lower Pole Breast Flaps

PubMed Central

Abdel-Monem, Kareem; Elshahat, Ahmed; Abou-Gamrah, Sherif; Eldin Abol-Atta, Hossam; Abd Eltawab, Reda; Massoud, Karim

2012-01-01

Objective: Reconstruction of a breast after mastectomy using the contralateral lower pole breast flap is an appealing procedure because it uses the tissues that were going to be excised during reduction of the sound breast to achieve symmetry. Literature mentioned that these flaps are supplied by the lower internal mammary artery perforators (IMAPs) with no further details. The aim of this study was to determine the site, size, and number of the 4th and 5th IMAPs by using preoperative color Duplex ultrasound and intraoperative exploration. Method: Twenty breasts in 10 patients who presented for reduction mammoplasty were included in this study. Preoperative color duplex was used to determine IMAPs in the 4th and 5th intercostal spaces. These perforators were localized intraoperatively. Intravenous fluorescein injection was used to determine the perfusion of the lower pole breast flap on the basis of these perforators. Results: Statistically, the 4th IMAPs diameters were significantly larger than the 5th IMAPs diameters (P < .05). The lower pole breast flap was perfused through these perforators. Conclusion: Color Duplex ultrasound is an accurate tool to preoperatively determine the 4th and 5th IMAPs. PMID:22292100

Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis.

PubMed

Wang, Hanru; Brook, Caitlin L; Whittaker, Alexandra L; Lawrence, Andrew; Yazbeck, Roger; Howarth, Gordon S

2013-08-01

Mucositis is a debilitating intestinal side effect of chemotherapeutic regimens. Probiotics have been considered a possible preventative treatment for mucositis. Streptococcus thermophilus TH-4 (TH-4), a newly identified probiotic, has been shown to partially alleviate mucositis induced by administration of the antimetabolite chemotherapy drug, methotrexate in rats; likely mediated through a mechanism of folate production. However, its effects against other classes of chemotherapy drug have yet to be determined. The authors investigated the effects of TH-4 in a rat model of mucositis induced by the anthracycline chemotherapy drug, doxorubicin. Gastrointestinal damage was induced in female Dark Agouti rats (148.3 ± 1.5 g) by intraperitoneal injection of doxorubicin (20 mg/kg). Animals recieved a daily oral gavage of TH-4 at 10(9) cfu/ml or skim milk (vehicle) from days 0 to 8. At day 6, rats were injected with either saline or doxorubicin. At kill, small intestinal tissues were collected for determination of sucrase and myeloperoxidase (MPO) activities and histological assessment. Body weight was significantly decreased by doxorubicin compared with normal controls (p < 0.05). Histological parameters, such as crypt depth and villus height, were also significantly decreased by doxorubicin. TH-4 partially prevented the loss of body weight induced by doxorubicin (2.3% compared with 4%), but provided no further therapeutic benefit. The minimal amelioration of doxorubicin-induced mucositis by TH-4 further supports folate production as a likely mechanism of TH-4 action against methotrexate-induced mucositis. Further studies into TH-4 are required to confirm its applicability to other conventional chemotherapy regimens.

English Leadership Quarterly, 1994.

ERIC Educational Resources Information Center

Strickland, James, Ed.; Kiernan, Henry, Ed.

1994-01-01

These 4 issues of the English Leadership Quarterly comprise volume 16, published during 1994. Articles in number 1 deal with practical advice, and include: "The Law of Privacy and the Writing Teacher" (Ben T. Allen); Beware of Teachers Who Laminate Their Lesson Plans and Other Useful Suggestions about Teaching" (Robert Perrin);…

16. 4th floor roof, view west, north side of setback ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. 4th floor roof, view west, north side of setback to left and delivery stair bulkhead to right - Sheffield Farms Milk Plant, 1075 Webster Avenue (southwest corner of 166th Street), Bronx, Bronx County, NY

Hydroacoustic Studies Using HydroCAM - Station-centric Integration of Models and Observations Quarterly Report No.4 July 2003 - September 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Upton, Zachary, M.; Pulli, Jay, J.

2003-10-13

OAK B272 Quarterly technical report summarizing BBN's efforts to improve DOE's hydroacoustic modeling and analysis capability for nuclear explosion monitoring. BBN's work during the third quarter of 2003 was focused on preparations for and participation in the 2003 Seismic Research Review Meeting, unit testing and bug fixes to HydroCAM 4.1, data collection and analysis, and procuring high-resolution bathymetric data. In an attempt to save money, BBN scaled back its labor in the third quarter, delaying some deliverables but saving contract funding in case our next increment is delayed. We have succeeded in finding the correct Naval contact that can helpmore » us procure high-resolution bathymetry data. Although these data may require the release of a classified version of HydroCAM, we are optimistic that we will be able to acquire and integrate high-resolution bathymetric data near the Indian Ocean IMS stations. HydroCAM 4.1, which includes the ability to make blockage predictions using varying resolution bathymetric data, has completed unit testing and is now under integration (release) testing. We hope to deliver that functionality to DOE and AFTAC in November. BBN improved its database of hydroacoustic events in the Indian Ocean by including meta-data for associated arrivals. For each earthquake event, BBN is now picking the direct arrival at each station (Diego Garcia North and South, and Cape Leeuwin) and associating that arrival with the origin information that we are compiling. The data for 2001, 2002 and 2003 (to date) will be delivered to LLNL for integration into the Knowledge Base during the fourth quarter of 2003.« less

Thermodynamic assessment of the LiF-NaF-BeF2-ThF4-UF4 system

NASA Astrophysics Data System (ADS)

Capelli, E.; Beneš, O.; Konings, R. J. M.

2014-06-01

The present study describes the full thermodynamic assessment of the LiF-NaF-BeF2-ThF4-UF4 system which is one of the key systems considered for a molten salt reactor fuel. The work is an extension of the previously assessed LiF-NaF-ThF4-UF4 system with addition of BeF2 which is characterized by very low neutron capture cross section and a relatively low melting point. To extend the database the binary BeF2-ThF4 and BeF2-UF4 systems were optimized and the novel data were used for the thermodynamic assessment of BeF2 containing ternary systems for which experimental data exist in the literature. The obtained database is used to optimize the molten salt reactor fuel composition and to assess its properties with the emphasis on the melting behaviour.

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

33 CFR 165.166 - Safety Zone: Macy's July 4th Fireworks, East River, NY.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Macy's July 4th... § 165.166 Safety Zone: Macy's July 4th Fireworks, East River, NY. (a) Regulated area. The following area.... on July 4th. If the event is cancelled due to inclement weather then this section is in effect from 6...

Kids & Family Reading Report™. 4th Edition

ERIC Educational Resources Information Center

Scholastic Inc., 2013

2013-01-01

This report presents the 4th Edition of Scholastic's biannual study of children's and parents' attitudes and behaviors about reading. Much has changed since the first "Kids & Family Reading Report" was issued in 2006, but literacy remains the critical skill needed for school success. Today's children are growing up in a world full of…

Trustee Quarterly, 2000-2001.

ERIC Educational Resources Information Center

Trustee Quarterly, 2001

2001-01-01

This document contains 4 issues of the Trustee Quarterly: fall 2000, spring 2001, summer 2001, and fall 2001. The fall 2000 issue contains seven features and six departments. Among the features are: "The New Economy: Who Will Lead the Education Movement," by Rucker; "Community Colleges Tackle IT Staffing Challenges," by Matina; and "Looking at…

Modeling of Synergy Between 4th and 6th Harmonic Absorptions of Fast Waves on Injected Beams in DIII-D Tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, M.; Pinsker, R. I.; Chan, V. S.

2011-12-23

In recent moderate to high harmonic fast wave heating and current drive experiments in DIII-D, a synergy effect was observed when the 6{sup th} harmonic 90 MHz fast wave power is applied to the plasma preheated by neutral beams and the 4{sup th} harmonic 60 MHz fast wave. In this paper, we investigate how the synergy can occur using ORBIT-RF coupled with AORSA. Preliminary simulations suggest that damping of 4{sup th} harmonic FW on beam ions accelerates them above the injection energy, which may allow significant damping of 6{sup th} harmonic FW on beam ion tails to produce synergy.

Impacts of a Discussion-Based Academic Language Program on Classroom Interactions in 4th through 7th Grades

ERIC Educational Resources Information Center

LaRusso, Maria; Jones, Stephanie M.; Kim, Ha Yeon; Kim, James; Donovan, Suzanne; Snow, Catherine

2016-01-01

This paper presents an exploratory analysis of treatment-control differences in the quality of classroom interactions in 4th through 7th grade urban classrooms. Word Generation (WG) is a research-based academic language program for middle school students designed to teach novel vocabulary and literacy through language arts, math, science, and…

The risk of a second diagnostic window with 4th generation HIV assays: Two cases.

PubMed

Niederhauser, C; Ströhle, A; Stolz, M; Müller, F; Tinguely, C

2009-08-01

Despite the improved sensitivity of the 4th generation combined antigen/antibody HIV assays, detection of HIV in the early phase of an infection may still be ineffective. Description of two cases that highlight the existence of the "second diagnostic window phase" observed with commonly used sensitive 4th generation HIV assays. Samples were screened with different 4th generation HIV assays. HIV infection was confirmed with an HIV I/II antibody assay, a HIV-1 p24 antigen assay, the INNO-LIA HIV I/II Score Line immunoassay and HIV-1 PCR. In both investigated cases, the limitations of the 4th generation HIV assays within the second diagnostic window were apparent. The overall sensitivity of the commercial 4th generation HIV assays is currently higher than the 3rd generation HIV assays. Nevertheless, the rare occurrence of a second diagnostic window with 4th generation HIV assays strongly suggests that the following up testing algorithms need to be adjusted accordingly.

Results For The Third Quarter Calendar Year 2016 Tank 50H Salt Solution Sample

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, C.

2016-10-13

In this memorandum, the chemical and radionuclide contaminant results from the Third Quarter Calendar Year 2016 (CY16) sample of Tank 50H salt solution are presented in tabulated form. The Third Quarter CY16 Tank 50H samples (a 200 mL sample obtained 6” below the surface (HTF-5-16-63) and a 1 L sample obtained 66” from the tank bottom (HTF-50-16-64)) were obtained on July 14, 2016 and received at Savannah River National Laboratory (SRNL) on the same day. Prior to obtaining the samples from Tank 50H, a single pump was run at least 4.4 hours, and the samples were pulled immediately after pumpmore » shut down. The information from this characterization will be used by Defense Waste Processing Facility (DWPF) & Saltstone Facility Engineering for the transfer of aqueous waste from Tank 50H to the Saltstone Production Facility, where the waste will be treated and disposed of in the Saltstone Disposal Facility. This memorandum compares results, where applicable, to Saltstone Waste Acceptance Criteria (WAC) limits and targets. Data pertaining to the regulatory limits for Resource Conservation and Recovery Act (RCRA) metals will be documented at a later time per the Task Technical and Quality Assurance Plan (TTQAP) for the Tank 50H saltstone task. The chemical and radionuclide contaminant results from the characterization of the Third Quarter CY16 sampling of Tank 50H were requested by Savannah River Remediation (SRR) personnel and details of the testing are presented in the SRNL TTQAP.« less

Education Statistics Quarterly. Volume 6, Issue 4, 2004. NCES 2006-613

ERIC Educational Resources Information Center

National Center for Education Statistics, 2006

2006-01-01

The "Quarterly" offers a comprehensive overview of work done across all of the National Center for Education Statistics (NCES). Each issue includes short publications and summaries covering all NCES publications and data products released in a given time period as well as notices about training and funding opportunities. In addition,…

Learning in the Workplace. Quarterly News. Volume 1, Nos. 1-4.

ERIC Educational Resources Information Center

Learning in the Workplace, 1990

1990-01-01

This document contains the first four issues of a quarterly publication on workplace literacy and learning in the workplace. The September 1989 issues feature the following articles or excerpts: "Workplace Literacy--Initiatives for Growth in the 90s"; "Yes! There Is a Cure for the Babblespeak Blues" (Nore); "Review: The…

CSSEDC Quarterly. 1989.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1989-01-01

These four issues of the CSSEDC Quarterly (Conference for Secondary School English Department Chairpersons) represent the quarterly for 1989. Articles in number 1 deal with professional development, and include: "Sharing Expertise within a Department" (Martha R. Dolly); "Empowerment Develops a Computer Writing Center" (Norman…

75 FR 35649 - Safety Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... Zone; Northern California Annual Fireworks Events, July 4th Fireworks Display AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the Tahoe City 4th of... safety zone for the annual Tahoe City 4th of July Fireworks in 33 CFR 165.1191 on July 4, 2010, from 9 a...

Preliminary Study on LiF4-ThF4-PuF4 Utilization as Fuel Salt of miniFUJI Molten Salt Reactor

NASA Astrophysics Data System (ADS)

Waris, Abdul; Aji, Indarta K.; Pramuditya, Syeilendra; Widayani; Irwanto, Dwi

2016-08-01

miniFUJI reactor is molten salt reactor (MSR) which is one type of the Generation IV nuclear energy systems. The original miniFUJI reactor design uses LiF-BeF2-ThF4-233UF4 as a fuel salt. In the present study, the use of LiF4-ThF4-PuF4 as fuel salt instead of LiF-BeF2-ThF4-UF4 will be discussed. The neutronics cell calculation has been performed by using PIJ (collision probability method code) routine of SRAC 2006 code, with the nuclear data library is JENDL-4.0. The results reveal that the reactor can attain the criticality condition with the plutonium concentration in the fuel salt is equal to 9.16% or more. The conversion ratio diminishes with the enlarging of plutonium concentration in the fuel. The neutron spectrum of miniFUJI MSR with plutonium fuel becomes harder compared to that of the 233U fuel.

12 CFR 327.12 - Prepayment of quarterly risk-based assessments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Prepayment of quarterly risk-based assessments... STATEMENTS OF GENERAL POLICY ASSESSMENTS In General § 327.12 Prepayment of quarterly risk-based assessments. (a) Requirement to prepay assessment. On December 30, 2009, each insured depository institution shall...

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

PubMed Central

Araya, Natsumi; Sato, Tomoo; Ando, Hitoshi; Tomaru, Utano; Yoshida, Mari; Coler-Reilly, Ariella; Yagishita, Naoko; Yamauchi, Junji; Hasegawa, Atsuhiko; Kannagi, Mari; Hasegawa, Yasuhiro; Takahashi, Katsunori; Kunitomo, Yasuo; Tanaka, Yuetsu; Nakajima, Toshihiro; Nishioka, Kusuki; Utsunomiya, Atae; Jacobson, Steven; Yamano, Yoshihisa

2014-01-01

Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma. Evidence suggests that HTLV-1, via the viral protein Tax, exploits CD4+ T cell plasticity and induces transcriptional changes in infected T cells that cause suppressive CD4+CD25+CCR4+ Tregs to lose expression of the transcription factor FOXP3 and produce IFN-γ, thus promoting inflammation. We hypothesized that transformation of HTLV-1–infected CCR4+ T cells into Th1-like cells plays a key role in the pathogenesis of HAM/TSP. Here, using patient cells and cell lines, we demonstrated that Tax, in cooperation with specificity protein 1 (Sp1), boosts expression of the Th1 master regulator T box transcription factor (T-bet) and consequently promotes production of IFN-γ. Evaluation of CSF and spinal cord lesions of HAM/TSP patients revealed the presence of abundant CD4+CCR4+ T cells that coexpressed the Th1 marker CXCR3 and produced T-bet and IFN-γ. Finally, treatment of isolated PBMCs and CNS cells from HAM/TSP patients with an antibody that targets CCR4+ T cells and induces cytotoxicity in these cells reduced both viral load and IFN-γ production, which suggests that targeting CCR4+ T cells may be a viable treatment option for HAM/TSP. PMID:24960164

4th Rare Disease South Eastern Europe (See) Meeting Skopje, Macedonia (November 14th, 2015).

PubMed

Gucev, Zoran; Tasic, Velibor; Polenakovic, Momir

2015-01-01

The 4th meeting on rare diseases in South Eastern Europe (SEE) was held in Skopje, at the Macedonian Academy of Sciences and Arts (MASA) on the 14(th) of November 2015. The focuses were metabolic, rare brain diseases as well as the rare dysmorphic syndrome. The authors of the report are particularly keen on stating that one of the main goals of the meeting, namely to help the treatment of patients with rare disease has begun to bear fruits. The talk on an iminosugar-based pharmacological chaperone compound as a drug candidate for the treatment of GM1-gangliosidosis and mucopolysaccharidosis IVB (Morquio disease type B) was enlightening. To date, there is no treatment available to be offered to patients, but chaperones lead mutated proteins to adopt a native-like conformation and to successfully traffic to their normal cellular destination. DORPHAN is developing an iminosugar-based pharmacological chaperone compound for the treatment of GM1-gangliosidosis and mucopolysaccharidosis IVB. A talk on recent developments in the laboratory diagnosis of mucopolysaccharidoses (MPS) was particularly interesting, covering the laboratory diagnosis of the MPS diseases by a strategy of clinical examination, biochemical analysis of urine samples, enzyme tests and genetic characterization of underlying mutations. New techniques were developed, including analysis of urinary glycosaminoglycans with tandem mass spectrometry, miniaturized enzyme tests or novel synthetic substrates for enzyme assays using mass spectrometry detection of products using dried blood spots. Feasibility and cost-effectiveness of these methods in newborn screening programs have been demonstrated. Neuromuscular RDs, and especially familial amyloid polyneuropathy (FAP) were a topic of the Bulgarian colleagues. Diagnosis, screening and the role of microglia were also topics of particular interest. In summary, this year RD meeting was exciting and productive on a wide range of diseases and on a novel insights on

Activation of CH4 by Th(+) as studied by guided ion beam mass spectrometry and quantum chemistry.

PubMed

Cox, Richard M; Armentrout, P B; de Jong, Wibe A

2015-04-06

The reaction of atomic thorium cations with CH4 (CD4) and the collision-induced dissociation (CID) of ThCH4(+) with Xe are studied using guided ion beam tandem mass spectrometry. In the methane reactions at low energies, ThCH2(+) (ThCD2(+)) is the only product; however, the energy dependence of the cross-section is inconsistent with a barrierless exothermic reaction as previously assumed on the basis of ion cyclotron resonance mass spectrometry results. The dominant product at higher energies is ThH(+) (ThD(+)), with ThCH3(+) (ThCD3(+)) having a similar threshold energy. The latter product subsequently decomposes at still higher energies to ThCH(+) (ThCD(+)). CID of ThCH4(+) yields atomic Th(+) as the exclusive product. The cross-sections of all product ions are modeled to provide 0 K bond dissociation energies (in eV) of D0(Th(+)-H) ≥ 2.25 ± 0.18, D0(Th(+)-CH) = 6.19 ± 0.16, D0(Th(+)-CH2) ≥ 4.54 ± 0.09, D0(Th(+)-CH3) = 2.60 ± 0.30, and D0(Th(+)-CH4) = 0.47 ± 0.05. Quantum chemical calculations at several levels of theory are used to explore the potential energy surfaces for activation of methane by Th(+), and the effects of spin-orbit coupling are carefully considered. When spin-orbit coupling is explicitly considered, a barrier for C-H bond activation that is consistent with the threshold measured for ThCH2(+) formation (0.17 ± 0.02 eV) is found at all levels of theory, whereas this barrier is observed only at the BHLYP and CCSD(T) levels otherwise. The observation that the CID of the ThCH4(+) complex produces Th(+) as the only product with a threshold of 0.47 eV indicates that this species has a Th(+)(CH4) structure, which is also consistent with a barrier for C-H bond activation. This barrier is thought to exist as a result of the mixed ((4)F,(2)D) electronic character of the Th(+) J = (3)/2 ground level combined with extensive spin-orbit effects.

CSSEDC Quarterly. 1990.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1990-01-01

These four issues of the CSSEDC Quarterly (Conference for Secondary School English Department Chairpersons) represent the quarterly for 1990. Articles in number 1 deal with student teachers and include: "Student Teaching: Smoothing Out the Rough Spots" (Susan B. Argyle and Fred C. Feitler); "A Partnership for Urban Student…

Quarterly Coal Distribution

EIA Publications

2017-01-01

The Quarterly Coal Distribution Report (QCDR) provides detailed U.S. domestic coal distribution data by coal origin state, coal destination state, mode of transportation, and consuming sector. Quarterly data for all years are preliminary and will be superseded by the release of the corresponding Annual Coal Distribution Report.

77 FR 40266 - Safety Zone; Conneaut 4th of July Festival, Lake Erie, Conneaut, OH

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... 1625-AA00 Safety Zone; Conneaut 4th of July Festival, Lake Erie, Conneaut, OH AGENCY: Coast Guard, DHS... the Conneaut 4th of July Festival Fireworks display. This temporary safety zone is necessary to... vessels during the Conneaut 4th of July Festival Fireworks. This zone will be effective and enforced from...

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.

PubMed

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-05-02

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome.

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster

PubMed Central

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-01-01

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome. PMID:17318176

4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions.

PubMed

Puppala, Manohar; Zhao, Xinghua; Casemore, Denise; Zhou, Bo; Aridoss, Gopalakrishnan; Narayanapillai, Sreekanth; Xing, Chengguo

2016-03-15

4H-Chromene-based compounds, for example, CXL017, CXL035, and CXL055, have a unique anticancer potential that they selectively kill multi-drug resistant cancer cells. Reported herein is the extended structure-activity relationship (SAR) study, focusing on the ester functional group at the 4th position and the conformation at the 6th position. Sharp SARs were observed at both positions with respect to cellular cytotoxic potency and selectivity between the parental HL60 and the multi-drug resistant HL60/MX2 cells. These results provide critical guidance for future medicinal optimization. Copyright © 2016. Published by Elsevier Ltd.

77 FR 39172 - Safety Zone: Skagway Harbor, Skagway, AK for 4th of July Fireworks

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

...-AA00 Safety Zone: Skagway Harbor, Skagway, AK for 4th of July Fireworks AGENCY: Coast Guard, DHS... of the Small Boat Harbor, Skagway, Alaska, to limit access for the duration of the 4th of July... Inlet for the City of Skagway, Alaska, sponsored 4th of July fireworks display. A no-action alternative...

The Quarterly of the National Writing Project and the Center for the Study of Writing. Vol 11 No. 1-4.

ERIC Educational Resources Information Center

Sperling, Melanie, Ed.; Ylvisaker, Miriam, Ed.

1989-01-01

These four issues of The Quarterly of the National Writing Project cover the calendar year 1989. The January 1989 issue contains the following articles: (1) "The Unteachables" (J. Juska); (2) "Changing the Model" (M. Griffith and others); (3) "Literate Cultures: Multi-Voiced Classrooms" (M. Roemer); (4) "Despite…

Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia

PubMed Central

Saito, S; Sakai, M; Sasaki, Y; Tanebe, K; Tsuda, H; Michimata, T

1999-01-01

We calculated the percentage of Th1, Th2, Th0 cells and the Th1:Th2 cell ratio of peripheral blood from normal pregnant subjects and preeclampsia patients using flow cytometry which can analyse both the surface marker, CD4, and intracellular cytokines, interleukin (IL)-4 and interferon (IFN)-γ. In normal pregnancy, the percentage of Th1 cells was significantly lower in the third trimester, and the ratios of Th1:Th2 were significantly lower in the second and third trimester than in nonpregnant subjects. In contrast, the percentage of Th1 cells and the ratios of Th1:Th2 in preeclampsia were significantly higher than in normal third trimester pregnant subjects. The percentage of Th2 cells in preeclampsia was significantly lower than in third trimester of normal pregnancy. Additionally, peripheral blood mononuclear cells from these subjects and patients were cultured with phytohemagglutinin stimulation, and IL-4 and IFN-γ concentrations were determined in the supernatant by enzymed linked immunosorbent assays. The percentage of Th1 and Th2, and the ratios of Th1:Th2 were correlated with cytokine (IFN-γ and IL-4) secretion level. These results demonstrated that Th2 cells were predominant in the second and third trimesters of normal pregnancy, but Th1 cells predominated in preeclamptic patients. PMID:10469061

Applied Meteorology Unit (AMU) Quarterly Report. First Quarter FY-05

NASA Technical Reports Server (NTRS)

Bauman, William; Wheeler, Mark; Lambert, Winifred; Case, Jonathan; Short, David

2005-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the first quarter of Fiscal Year 2005 (October - December 2005). Tasks reviewed include: (1) Objective Lightning Probability Forecast: Phase I, (2) Severe Weather Forecast Decision Aid, (3) Hail Index, (4) Stable Low Cloud Evaluation, (5) Shuttle Ascent Camera Cloud Obstruction Forecast, (6) Range Standardization and Automation (RSA) and Legacy Wind Sensor Evaluation, (7) Advanced Regional Prediction System (ARPS) Optimization and Training Extension, and (8) User Control Interface for ARPS Data Analysis System (ADAS) Data Ingest

Applied Meteorology Unit (AMU) Quarterly Report - Fourth Quarter FY-09

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

2009-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the fourth quarter of Fiscal Year 2009 (July - September 2009). Tasks reports include: (1) Peak Wind Tool for User Launch Commit Criteria (LCC), (2) Objective Lightning Probability Tool. Phase III, (3) Peak Wind Tool for General Forecasting. Phase II, (4) Update and Maintain Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS), (5) Verify MesoNAM Performance (6) develop a Graphical User Interface to update selected parameters for the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLlT)

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

PubMed

Chen, Q; Muramoto, K; Masaaki, N; Ding, Y; Yang, H; Mackey, M; Li, W; Inoue, Y; Ackermann, K; Shirota, H; Matsumoto, I; Spyvee, M; Schiller, S; Sumida, T; Gusovsky, F; Lamphier, M

2010-05-01

Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17 cells, which infiltrate and damage tissues and induce inflammation. Prostaglandin E(2) (PGE(2)) enhances the Th17 response, exacerbates collagen-induced arthritis (CIA) and promotes inflammatory pain. The current study investigated whether selective antagonism of the PGE(2) EP(4) receptor would suppress Th1/Th17 cell development and inflammatory arthritis in animal models of RA. Effects of PGE(2) and a novel EP(4) receptor antagonist ER-819762 on Th1 differentiation, interleukin-23 (IL-23) production by dendritic cells (DCs), and Th17 development were assessed in vitro. The effect of ER-819762 was evaluated in CIA and glucose-6-phosphate isomerase (GPI)-induced arthritis models. In addition, the effects of ER-819762 on pain were evaluated in a model of chronic inflammatory pain induced by complete Freund's adjuvant (CFA) in the rat. Stimulation of the EP(4) receptor enhanced Th1 differentiation via phosphatidylinositol 3 kinase signalling, selectively promoted Th17 cell expansion, and induced IL-23 secretion by activated DCs, effects suppressed by ER-819762 or anti-PGE(2) antibody. Oral administration of ER-19762 suppressed Th1 and Th17 cytokine production, suppressed disease in collagen- and GPI-induced arthritis in mice, and suppressed CFA-induced inflammatory pain in rats. PGE(2) stimulates EP(4) receptors to promote Th1 differentiation and Th17 expansion and is critically involved in development of arthritis in two animal models. Selective suppression of EP(4) receptor signalling may have therapeutic value in RA both by modifying inflammatory arthritis and by relieving pain.

Crew Quarters Modifications

NASA Image and Video Library

2018-03-30

Modifications and upgrades are underway inside the Astronaut Crew Quarters in the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The crew quarters are being prepared for the next generation of space explorers. The historic facility housed Apollo and space shuttle astronauts before and after their missions into space.

Oak Ridge National Laboratory [ORNL] Review, Vol. 25, Nos. 3 and 4, 1992 [The First Fifty Years

DOE R&D Accomplishments Database

Krause, C.(ed.)

1992-01-01

In observation of the 50th anniversary of Oak Ridge National Laboratory, this special double issue of the Review contains a history of the Laboratory, complete with photographs, drawings, and short accompanying articles. Table of contents include: Wartime Laboratory; High-flux Years; Accelerating Projects; Olympian Feats; Balancing Act; Responding to Social Needs; Energy Technologies; Diversity and Sharing; Global Outreach; Epilogue

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY 2014 First Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Sanborn, Scott E.; Simmons, Kevin L.

2014-02-19

The CRADA between PNNL, Autodesk, Toyota and Magna has been effective since October 28th, 2013. The whole team including CRADA and subcontract partners kicked off the project technically on November 1st, 2013. This report describes work performed during the first quarter of FY 2014. The following technical progresses have been made toward project milestones: 1) The project kickoff meeting was organized at PlastiComp, Inc. in Winona on November 13th, 2013 involving all the project partners. During this meeting the research plan and Gantt chart were discussed and refined. The coordination of the research activities among the partners was also discussedmore » to ensure that the deliverables and timeline will be met. 2) Autodesk delivered a research version of ASMI to PNNL for process modeling using this tool under the project. PNNL installed this research version on a PNNL computer and tested it. Currently, PNNL is using ASMI to prepare the models for PlastiComp plaques. 3) PlastiComp has compounded long carbon-fiber reinforced polypropylene and polyamide 6,6 compounds for rheological and thermal characterization tests by the Autodesk laboratories in Melbourne, Australia. 4) Initial mold flow analysis was carried out by PlastiComp to confirm that the 3D complex part selected by Toyota as a representative automotive part is moldable. 5) Toyota, Magna, PlastiComp and PNNL finalized the planning for molding the Toyota 3D complex part. 6) Purdue University worked with PNNL to update and specify the test matrix for characterization of fiber length/orientation. 7) Purdue University developed tools to automate the data collection and analysis of fiber length and orientation measurements. 8) Purdue University designed and specified equipment to replace the need for equipment using the technology established by the University of Leeds at General Motors.« less

11. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO NORTHEAST, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO NORTHEAST, WITH WRAPPER (LEFT), PRESS (CENTER), AND CUTTER (RIGHT, BEHIND CHUTE); BUCKET CONVEYOR AT RIGHT MOVED WASTE FROM PRESS TO 5TH FLOOR FOR RE-MANUFACTURE - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

Guanine nucleotide-binding protein α subunit hypofunction in children with short stature and disproportionate shortening of the 4th and 5th metacarpals.

PubMed

Inta, Ioana Monica; Choukair, Daniela; Bender, Sebastian; Kneppo, Carolin; Knauer-Fischer, Sabine; Meyenburg, Kahina; Ivandic, Boris; Pfister, Stefan M; Bettendorf, Markus

2014-01-01

GNAS encodes the α subunit of the stimulatory G protein (Gsα). Maternal inherited Gsα mutations cause pseudohypoparathyroidism type Ia (PHP-Ia), associated with shortening of the 4th and 5th metacarpals. Here we investigated the Gsα pathway in short patients with distinct shortening of the 4th and 5th metacarpals. In 571 children with short stature and 4 patients with PHP-Ia metacarpal bone lengths were measured. In identified patients we analysed the Gsα protein function in platelets, performed GNAS sequencing, and epigenetic analysis of four significant differentially methylated regions. In 51 patients (8.9%) shortening of the 4th and 5th metacarpals was more pronounced than their height deficit. No GNAS coding mutations were identified in 20 analysed patients, except in 2 PHP-Ia patients. Gsα activity was reduced in all PHP-Ia patients and in 25% of the analysed patients. No significant methylation changes were identified. Our findings suggest that patients with short stature and distinct metacarpal bone shortening could be part of the wide variety of PHP/PPHP, therefore it was worthwhile analysing the Gsα protein function and GNAS gene in these patients in order to further elucidate the phenotype and genotype of Gsα dysfunction.

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

49 CFR 228.101 - Distance requirement for employee sleeping quarters; definitions used in this subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Distance requirement for employee sleeping... OF SERVICE OF RAILROAD EMPLOYEES; RECORDKEEPING AND REPORTING; SLEEPING QUARTERS Construction of Railroad-Provided Sleeping Quarters § 228.101 Distance requirement for employee sleeping quarters...

Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice.

PubMed

Zeis, M; Uharek, L; Hartung, G; Glass, B; Steinmann, J; Schmitz, N

2001-01-01

The transfer of allogeneic lymphocytes contained in a hematopoietic stem cell graft confers an immune-mediated antileukemic effect, termed the graft-vs-leukemia (GVL) effect. Graft-vs-host disease (GVHD), the most detrimental complication of allogeneic BMT, largely resides within the same lymphocyte population. Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells. The objective of the current study was to assess the potential of Th1- and Th2-type CD4+ T cells in mediating GVHD and GVL effects in a fully allogeneic murine transplant model. BALB/c (H-2d) mice were given a dose of A20 (H-2d, B-cell leukemia) cells two days prior to lethal total body irradiation (TBI) and transplantation of fully mismatched (C57BL/6, H-2b) T-cell depleted (anti-Thy1.2, CD90) bone marrow (TCD-BM) cells. Graded numbers of either unmanipulated, Th1- or Th2-polarized highly enriched CD4+ donor type T cells (10(6) or 10(7)) were administered 2 h posttransplant. Infusion of 10(6) of unmanipulated, Th1-, or Th2-primed CD4+ T cells resulted in moderate GVHD-related mortality (40%, 50%, 10%) and significantly improved long-term survival (50%, 45%, 46% surviving the observation period of 120 days) as compared to animals receiving TCD-BM alone (18%). The administration of 10(7) unmanipulated or Th1-type CD4+ T cells given shortly after transplantation led to death of all mice within 50 days due to fatal acute GVHD. In contrast, the adoptive transfer of 10(7) Th2-primed CD4+ T cells resulted in significant improvement of long-term survival (80%) compared to the TCD-BM group. This powerful GVL effect was associated with a substantially lower incidence of lethal acute GVHD (10%) if compared to the results of transplantation of Th1-type CD4+ T cells. These results demonstrate that allogeneic Th2-type CD4+ T cells given post BMT can induce GVL effects in a cell-dose-dependent manner without

29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PAY Interpretations Authorized Basic Rates § 548.306 Average earnings for year or quarter year... regular rates of pay during the current quarter year, and (ii) such average hourly remuneration during the... 29 Labor 3 2011-07-01 2011-07-01 false Average earnings for year or quarter year preceding the...

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation.

PubMed

Carrión, Flavio; Nova, Estefania; Luz, Patricia; Apablaza, Felipe; Figueroa, Fernando

2011-03-30

Mesenchymal stem cells (MSCs) are multipotent progenitors with broad immunosuppressive properties. However, their therapeutic use in autoimmune disease models has shown dissimilar effects when applied at different stages of disease. We therefore investigated the effect of the addition of MSCs on the differentiation of Th1, Treg and Th17 cells in vitro, at different states of CD4(+) T cell activation. CD4(+) T lymphocytes purified by negative selection from mouse C57BL/6 splenocytes were cultured under Th1, Th17 and Treg inducing conditions with IL-12, TGF-β+IL-6 or TGF-β, respectively. C57BL/6 bone marrow derived MSCs were added to CD4(+) T cell cultures at day 0 or after 3 days of T cell polarizing activation. Intracellular cytokines for Th1, Th17 and Treg cells were quantitated at day 6 by flow cytometry. While early addition (day 0) of MSCs suppressed all CD4(+) T cell lineages, addition at day 3 only decreased IFN-γ production by Th1 polarized cells by 64% (p<0.05) while markedly increased IL-17 production by Th17 polarized cells by 50% (p<0.05) and left IL-10 production by Treg polarized cells unchanged. MSCs exhibit their typical suppressive phenotype when added early to cell cultures in the presence of CD4(+) T cell polarizing stimuli. However, once T cell activation has occurred, MSCs show an opposite stimulating effect on Th17 cells, while leaving Treg IL-10 producing cells unchanged. These results suggest that the therapeutic use of MSCs in vivo might exert opposing effects on disease activity, according to the time of therapeutic application and the level of effector T cell activation. Copyright © 2010 Elsevier B.V. All rights reserved.

76 FR 37650 - Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

...-AA00 Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA AGENCY: Coast... the 4th of July Festival Berkeley Marina Fireworks Display. Unauthorized persons or vessels are... display. Background and Purpose The City of Berkeley Marina will sponsor the 4th of July Festival Berkeley...

PREFACE: 4th International Conference on Safe Production and Use of Nanomaterials (Nanosafe2014)

NASA Astrophysics Data System (ADS)

Tardif, F.; Damlencourt, J.-F.; Schuster, F.; Gaultier, V.

2015-05-01

This volume contains a collection of contributions presented at the 4th International Conference on Safe Production and Use of Nanomaterials (NANOSAFE 2014) held in Grenoble, France, from 18th to 20th November 2014. The issues of fast progress in the field of Nanosafety are up to the potential benefits that nanotechnology can bring to mankind. Making more efficient - more sustainable - easier to share mineral resources, increasing the yields of new energy technologies, enabling drugs that act selectively and locally are just few examples of the wide range of nanomaterial applications that currently benefit humanity. Nevertheless, the dynamic development of nanomaterials requires the adhesion from the general public who rightly demand major progresses in Nanosafety as a prerequisite. This is our exciting responsibility and challenge! Following the successful outcome of the three past international conferences on safe production and use of nanomaterials: Nanosafe 2008, 2010 and 2012, the organizing committee has the pleasure to welcoming you again to Minatec, Grenoble with some of the most famous specialists in the field. This year, two new topics have been added dealing with the "New Application of Nanomaterials" and "Nano-responsible Development" in addition to the usual issues addressed in previous Nanosafe conferences such as Expology, Detection and Characterization, Toxicology, Environmental Interactions, Nanomaterials Release, Life Cycle Analysis, Regulation and Standardization, Risk Management. The debates in 2012 proved highly successful so this formula has been kept in 2014 with 3 round tables: Nano-Responsible Development, Risks and Benefits for the Environment, Toxicology Progress. In this 4th edition, there were more than 330 registered participants from 28 different countries including 160 oral presentation covering the whole Nanosafety issues in 12 sessions, satellite workshops and round tables. This high number of participants makes this edition one of

Upregulation of bacterial-specific Th1 and Th17 responses that are enriched in CXCR5+CD4+ T cells in non-small cell lung cancer.

PubMed

Ma, Qin-Yun; Huang, Da-Yu; Zhang, Hui-Jun; Wang, Shaohua; Chen, Xiao-Feng

2017-11-01

The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examined the Th1 and Th17 responses toward several bacterial antigens, in CD4 + T cells sourced from the peripheral blood (PB), the lung cancer (LC) tissue, and the gastrointestinal (GI) tract of non-small cell lung cancer (NSCLC) patients. Compared to healthy controls, the NSCLC patients presented significantly higher frequencies of Th1 and Th17 cells reacting to Streptococcus salivarius and S. agalactiae, in the PB, LC, and GI tract. Further investigation showed that the upregulation in anti-bacteria response was likely antigen-specific for two reasons. Firstly, the frequencies of Th1 and Th17 cells reacting to Escherichia coli, a typical GI bacterium, were not upregulated in the PB and the LC of NSCLC patients. Secondly, the S. salivarius and S. agalactiae responses could be partially blocked by Tü39, a MHC class II blocking antibody, suggesting that antigen-specific interaction between CD4 + T cells and antigen-presenting cells was required. We also found that S. salivarius and S. agalactiae could potently activate the monocytes to secrete higher levels of interleukin (IL)-6, IL-12, and tumor necrosis factor, which were Th1- and Th17-skewing cytokines. Interestingly, whereas CXCR5 + CD4 + T cells represented <20% of total CD4 + T cells, they represented 17%-82% of bacteria-specific Th1 or Th17 cells. Together, these data demonstrated that NSCLC patients presented a significant upregulation of bacterial-specific Th1 and Th17 responses that were enriched in CXCR5 + CD4 + T cells. Copyright © 2017 Elsevier B.V. All rights reserved.

NASA Astrophysics E/PO: A Quarter Century of Discovery and Inspiration with the Hubble Space Telescope

NASA Astrophysics Data System (ADS)

Jirdeh, Hussein; Straughn, Amber; Smith, Denise Anne; Eisenhamer, Bonnie

2015-08-01

April 24, 2015 marked the 25th anniversary of the launch of the Hubble Space Telescope. In its quarter-century in orbit, the Hubble Space Telescope has transformed the way we understand the Universe, helped us find our place among the stars, and paved the way to incredible advancements in science and technology.In this presentation, we explain how NASA and ESA, including the Space Telescope Science Institute (STScI) and partners, is using the 25th anniversary of Hubble’s launch as a unique opportunity to communicate to students, educators, and the public the significance of the past quarter-century of discovery with the Hubble Space Telescope. We describe the various programs, resources, and experiences we are utilizing to enhancethe public understanding of Hubble’s many contributions to the scientific world. These include educator professional development opportunities, exhibits, events, traditional and social media, and resources for educators (formal k-12, informal, and higher education). We also highlight how we are capitalizing on Hubble’s cultural popularity to make the scientific connection to NASA’s next Great Observatory, the James Webb Space Telescope.This presentation highlights many of the opportunities by which students, educators, and the public are joining in the anniversary activities, both in-person and online. Find out more at hubble25th.org and follow #Hubble25 on social media.

41 CFR 302-6.1 - What are “temporary quarters?”

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true What are âtemporary quarters?â 302-6.1 Section 302-6.1 Public Contracts and Property Management Federal Travel Regulation... TRANSPORTATION EXPENSES 6-ALLOWANCE FOR TEMPORARY QUARTERS SUBSISTENCE EXPENSES General Rules § 302-6.1 What are...

77 FR 30242 - Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

...-AA00 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY AGENCY: Coast... vessels from a portion of the Niagara River during the City of Tonawanda July 4th Celebration fireworks... read as follows: Sec. 165.T09-0352 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River...

Communicating Science to Impact Learning? A Phenomenological Inquiry into 4th and 5th Graders' Perceptions of Science Information Sources

ERIC Educational Resources Information Center

Gelmez Burakgazi, Sevinc; Yildirim, Ali; Weeth Feinstein, Noah

2016-01-01

Rooted in science education and science communication studies, this study examines 4th and 5th grade students' perceptions of science information sources (SIS) and their use in communicating science to students. It combines situated learning theory with uses and gratifications theory in a qualitative phenomenological analysis. Data were gathered…

ThMYC4E, candidate Blue aleurone 1 gene controlling the associated trait in Triticum aestivum

PubMed Central

Chen, Wenjie; Zhang, Bo; Wang, Daowen; Liu, Dengcai; Zhang, Huaigang

2017-01-01

Blue aleurone is a useful and interesting trait in common wheat that was derived from related species. Here, transcriptomes of blue and white aleurone were compared for isolating Blue aleurone 1 (Ba1) transferred from Thinopyrum ponticum. In the genes involved in anthocyanin biosynthesis, only a basic helix-loop-helix (bHLH) transcription factor, ThMYC4E, had a higher transcript level in blue aleurone phenotype, and was homologous to the genes on chromosome 4 of Triticum aestivum. ThMYC4E carried the characteristic domains (bHLH-MYC_N, HLH and ACT-like) of a bHLH transcription factor, and clustered with genes regulating anthocyanin biosynthesis upon phylogenetic analysis. The over-expression of ThMYC4E regulated anthocyanin biosynthesis with the coexpression of the MYB transcription factor ZmC1 from maize. ThMYC4E existed in the genomes of the addition, substitution and near isogenic lines with the blue aleurone trait derived from Th. ponticum, and could not be detected in any germplasm of T. urartu, T. monococcum, T. turgidum, Aegilops tauschii or T. aestivum, with white aleurone. These results suggested that ThMYC4E was candidate Ba1 gene controlling the blue aleurone trait in T. aestivum genotypes carrying Th. ponticum introgression. The ThMYC4E isolation aids in better understanding the genetic mechanisms of the blue aleurone trait and in its more effective use during wheat breeding. PMID:28704468

50th anniversary of Clinical Chemistry and Laboratory Medicine--a historical overview.

PubMed

Körber, Friedrich; Plebani, Mario

2013-01-01

In the early 1960s, Joachim Brugsch, one of the founders of Clinical Chemistry and Laboratory Medicine (CCLM) (then Zeitschrift für Klinische Chemie), had the idea to found a journal in the upcoming field of clinical chemistry. He approached Ernst Schütte, who was associated with the De Gruyter publishing house through another journal, to participate, and Schütte thus became the second founder of this Journal. The aim was to create a vehicle allowing the experts to express their opinions and raise their voices more clearly than they could in a journal that publishes only original experimental papers, a laborious and difficult, but important endeavor, as the profession of clinical chemistry was still in the early stages of development at this time. The first issue of this Journal was published in early 1963, and today, we are proud to celebrate the 50th anniversary of CCLM. This review describes the development of this Journal in light of the political situation of the time when it was founded, the situation of the publisher Walter De Gruyter after the erection of the Berlin Wall, and the development of clinical chemistry, and later on, laboratory medicine as a well-acknowledged discipline and profession.

Native American Students' Understanding of Geologic Time Scale: 4th-8th Grade Ojibwe Students' Understanding of Earth's Geologic History

ERIC Educational Resources Information Center

Nam, Younkyeong; Karahan, Engin; Roehrig, Gillian

2016-01-01

Geologic time scale is a very important concept for understanding long-term earth system events such as climate change. This study examines forty-three 4th-8th grade Native American--particularly Ojibwe tribe--students' understanding of relative ordering and absolute time of Earth's significant geological and biological events. This study also…

75 FR 38721 - Safety Zone; Munising 4th of July Fireworks, South Bay, Lake Superior, Munising, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-AA00 Safety Zone; Munising 4th of July Fireworks, South Bay, Lake Superior, Munising, MI AGENCY: Coast... portion of South Bay during the Munising 4th of July Fireworks display, July 4, 2010. This temporary... from hazards associated with the Munising 4th of July Fireworks display. Based on the explosive hazards...

75 FR 34379 - Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...-AA00 Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI AGENCY: Coast... of Lake Huron during the Mackinac Island 4th of July Fireworks display on July 4, 2010. This... and vessels during the setup, and launching of fireworks in conjunction with the Mackinac Island 4th...

English Leadership Quarterly. 1991.

ERIC Educational Resources Information Center

Strickland, James, Ed.

1991-01-01

These four issues of the English Leadership Quarterly represent the quarterly for 1991. Articles in number 1 deal with whole language and include: "CEL: Shorter and Better" (Myles D. Eley); "Toward a New Philosophy of Language Learning" (Kathleen Strickland); "Whole Language: Implications for Secondary Classrooms"…

10. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO SOUTHWEST, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. 4TH FLOOR, HOTEL SOAP LINE No. 6 TO SOUTHWEST, WITH AUTOMATIC CUTTER (LEFT), PRESS (CENTER), AND WRAPPER (RIGHT); LARGE CHUTE AT CENTER FROM 5TH FLOOR BINS TO 3RD FLOOR SOAP MILLS; OVERHEAD AND FLOOR (LOWER RIGHT) FINISHED GOODS CONVEYORS TO G BLOCK (HAER NO. NJ-71-NN) - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY REQUIREMENTS FOR INDUSTRIAL RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly...

Th(As(III)4As(V)4O18): a mixed-valent oxoarsenic(III)/arsenic(V) actinide compound obtained under extreme conditions.

PubMed

Yu, Na; Klepov, Vladislav V; Kegler, Philip; Bosbach, Dirk; Albrecht-Schmitt, Thomas E; Alekseev, Evgeny V

2014-08-18

A high-temperature/high-pressure method was employed to investigate phase formation in the Th(NO3)4·5H2O-As2O3-CsNO3 system. It was observed that an excess of arsenic(III) in starting system leads to the formation of Th(As(III)4As(V)4O18), which is representative of a rare class of mixed-valent arsenic(III)/arsenic(V) compounds. This compound was studied with X-ray diffraction, energy-dispersive X-ray, and Raman spectroscopy methods. Crystallographic data show that Th(As(III)4As(V)4O18) is built from (As(III)4As(V)4O18)(4-) layers connected through Th atoms. The arsenic layers are found to be isoreticular to those in previously reported As2O3 and As3O5(OH), and the geometric differences between them are discussed. Bands in the Raman spectrum are assigned with respect to the presence of AsO3 and AsO4 groups.

The school nutrition program's role in weight management of 4th grade elementary students

USDA-ARS?s Scientific Manuscript database

We are attempting to uncover the school nutrition program's role in weight management of 4th grade elementary students. Data was collected within a time frame for the food frequency questionnaire (FFQ) set at two months at the WT Cheney Elementary School and South Wood Elementary for 4th grade stud...

Results for the first quarter calendar year 2017 tank 50H salt solution sample

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, C. L.

2017-04-12

In this memorandum, the chemical and radionuclide contaminant results from the First Quarter Calendar Year 2017 (CY17) sample of Tank 50H salt solution are presented in tabulated form. The First Quarter CY17 Tank 50H samples [a 200 mL sample obtained 6” below the surface (HTF-50-17-7) and a 1 L sample obtained 66” from the tank bottom (HTF-50-17-8)] were obtained on January 15, 2017 and received at Savannah River National Laboratory (SRNL) on January 16, 2017. Prior to obtaining the samples from Tank 50H, a single pump was run at least 4.4 hours and the samples were pulled immediately after pumpmore » shut down. All volatile organic analysis (VOA) and semi-volatile organic analysis (SVOA) were performed on the surface sample and all other analyses were performed on the variable depth sample. The information from this characterization will be used by Savannah River Remediation (SRR) for the transfer of aqueous waste from Tank 50H to the Saltstone Production Facility, where the waste will be treated and disposed of in the Saltstone Disposal Facility. This memorandum compares results, where applicable, to Saltstone Waste Acceptance Criteria (WAC) limits and targets. The chemical and radionuclide contaminant results from the characterization of the First Quarter CY17 sampling of Tank 50H were requested by SRR personnel and details of the testing are presented in the SRNL Task Technical and Quality Assurance Plan (TTQAP). This memorandum is part of Deliverable 2 from SRR request. Data pertaining to the regulatory limits for Resource Conservation and Recovery Act (RCRA) metals will be documented at a later time per the TTQAP for the Tank 50H saltstone task.« less

10 CFR 34.29 - Quarterly inventory.

Code of Federal Regulations, 2010 CFR

2010-01-01

... RADIOGRAPHIC OPERATIONS Equipment § 34.29 Quarterly inventory. (a) Each licensee shall conduct a quarterly physical inventory to account for all sealed sources and for devices containing depleted uranium received... 10 Energy 1 2010-01-01 2010-01-01 false Quarterly inventory. 34.29 Section 34.29 Energy NUCLEAR...

75 FR 35294 - Safety Zone; Marquette 4th of July Fireworks, Marquette Harbor, Lake Superior, Marquette, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-22

...-AA00 Safety Zone; Marquette 4th of July Fireworks, Marquette Harbor, Lake Superior, Marquette, MI... vessels from a portion of Marquette Harbor during the Marquette 4th of July Fireworks display. This... vessels during the setup and launching of fireworks in conjunction with the Marquette 4th of July...

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry.

PubMed

Sousa, Maria Emília; Araújo, Maria João; do Vale, Maria Luísa; Andrade, Paula B; Branco, Paula; Gomes, Paula; Moreira, Rui; Pinho E Melo, Teresa M V D; Freitas, Victor

2016-03-17

For the first time under the auspices of Sociedade Portuguesa de Química, the competences of two important fields of Chemistry are brought together into a single event, the 11st National Organic Chemistry Meeting and the the 4th National Medicinal Chemistry Meeting, to highlight complementarities and to promote new synergies. Abstracts of plenary lectures, oral communications, and posters presented during the meeting are collected in this report.

[A development of Byzantine Christian charities during the 4(th)-7(th) centuries and the birth of the hospital].

PubMed

Nam, Sung Hyun

2015-04-01

This study aims to examine the beginning and the development of Christian Charities during the 4(th)-6(th) centuries which would eventually result in the birth of the hospital in modern sense in the first half of the 7(th) century. For this purpose, I looked carefully into various primary sources concerning the early Christian institutions for the poor and the sick. Above all, it's proper to note that the first xenodocheion where hospitality was combined with a systematic caring, is concerned with the Trinitarian debate of the 4(th) century. In 356, Eustathios, one of the leaders of homoiousios group, established xenodocheion to care for the sick and the lepers in Sebaste of Armenia, whereas his opponent Aetios, doctor and leader of the heteroousios party, was reckoned to have combined the medical treatment with his clerical activities. Then, Basil of Caesarea, disciple of Eustathios of Sebaste, also founded in 372 a magnificent benevolent complex named 'Basileias' after its founder. I scrupulously analysed several contemporary materials mentioning the charitable institution of Caesarea which was called alternatively katagogia, ptochotropheion, xenodocheion. John Chrysostome also founded several nosokomeia in Constantinople at the end of the 4(th) century and the beginning of the 5(th) century. Apparently, the contemporary sources mention that doctors existed for these Charities, but there is no sufficient proof that these 'Christian Hospitals,' Basileias or nosokomeia of Constantinople were hospitals in modern sense. Imperial constitutions began to mention ptochotropheion, xenodocheion and orphanotropheion since the second half of the 5(th) century and then some Justinian laws evoked nosokomium, brephotrophia, gerontocomia. These laws reveal that 'Christian Hospitals' were well clarified and deeply rooted in Byzantine society already in these periods. And then, new benevolent institutions emerged in the 6(th) century: nosokomeia for a specific class and

Occidental vertical modified in situ process for the recovery of oil from oil shale. Phase II. Quarterly progress report, September 1, 1980-November 30, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-01-01

The major activities at OOSI's Logan Wash site during the quarter were: mining the voids at all levels for Retorts 7 and 8; blasthole drilling; tracer testing MR4; conducting the start-up and burner tests on MR3; continuing the surface facility construction; and conducting Retorts 7 and 8 related Rock Fragmentation tests. Environmental monitoring continued during the quarter, and the data and analyses are discussed. Sandia National Laboratory and Laramie Energy Technology Center (LETC) personnel were active in the DOE support of the MR3 burner and start-up tests. In the last section of this report the final oil inventory for Retortmore » 6 production is detailed. The total oil produced by Retort 6 was 55,696 barrels.« less

Quarterly Journal of Studies on Alcohol, Volume 32 Number 4, Part B, Documentation.

ERIC Educational Resources Information Center

Keller, Mark, Ed.

1971-01-01

Abstracts of current research related to alcohol problems and allied subjects are contained in this quarterly journal. Subject areas cover physiology-biochemistry, metabolism of alcohol, determination of alcohol, psychology, psychiatry, treatment of alcoholism, intoxication and its treatment, medical complications in alcoholism, social aspects,…

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.

PubMed

Luz-Crawford, Patricia; Kurte, Monica; Bravo-Alegría, Javiera; Contreras, Rafael; Nova-Lamperti, Estefania; Tejedor, Gautier; Noël, Danièle; Jorgensen, Christian; Figueroa, Fernando; Djouad, Farida; Carrión, Flavio

2013-06-04

Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be fully elucidated. One of the underlying mechanisms studied recently is the ability of MSCs to generate T regulatory (Treg) cells in vitro and in vivo from activated peripheral blood mononuclear cells (PBMC), T-CD4+ and also T-CD8(+) cells. In the present work we investigated the capacity of MSCs to generate Treg cells using T-CD4(+) cells induced to differentiate toward the proinflammatory Th1 and Th17 lineages. MSCs were obtained from mouse bone marrow and characterized according to their surface antigen expression and their multilineage differentiation potential. CD4(+) T cells isolated from mouse spleens were induced to differentiate into Th1 or Th17 cells and co-cultured with MSCs added at day 0, 2 or 4 of the differentiation processes. After six days, CD25, Foxp3, IL-17 and IFN-γ expression was assessed by flow cytometry and helios and neuropilin 1 mRNA levels were assessed by RT-qPCR. For the functional assays, the 'conditioned' subpopulation generated in the presence of MSCs was cultured with concanavalin A-activated CD4(+) T cells labeled with carboxyfluorescein succinimidyl ester. Finally, we used the encephalomyelitis autoimmune diseases (EAE) mouse model, in which mice were injected with MSCs at day 18 and 30 after immunization. At day 50, the mice were euthanized and draining lymph nodes were extracted for Th1, Th17 and Treg detection by flow cytometry. MSCs were able to suppress the proliferation, activation and differentiation of CD4(+) T cells induced to differentiate into Th1 and Th17 cells. This substantial suppressive effect was associated with an increase of the percentage of functional induced CD4(+)CD25(+)Foxp3(+) regulatory T cells and IL-10 secretion. However

Electric Power Quarterly, July-September 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-01-29

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. The data presented in this report were collected and published by the Energy Information Administration (EIA), to fulfill its responsibilities as specified in the Federal Energy Administration Act of 1974 (P.L. 93-275) as amended. This edition of the EPQ contains monthly data for the third quarter of 1985.

Report on the 4th International IUPAP Women in Physics Conference

NASA Astrophysics Data System (ADS)

Correa, Cynthia

2011-10-01

Stellenbosch, South Africa was the site of the 4^th International Union of Pure and Applied Physics (IUPAP) International Conference on Women in Physics, which took place on April 5^th-8^th. This conference brought together the diverse contributions of 250 female physicist attendees from nearly 60 countries worldwide to dissect the challenges faced by female physicists worldwide and to propose strategies to attract and retain more girls and women to the field. Having served as a member of the U.S. Delegation, I will discuss the resolutions reached and highlight the most important results of Global Survey of Physicists, where nearly 15,000 physicists shine light on how gender affects their lives and careers.

4th integrated transportation management systems (ITMS) conference : conference proceedings

DOT National Transportation Integrated Search

2001-08-01

This report documents the proceedings from the 4th Integrated Transportation Management Systems (ITMS) Conference, ITMS: A Key Strategy to Optimize Surface Transportation System Performance, held in Newark, New Jersey on July 15-18, 2001. The Confere...

4th International Plant Biomechanics Conference Proceedings (Abstracts)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frank W. Telewski; Lothar H. Koehler; Frank W. Ewers

2003-07-20

The 4th International Plant Biomechanics Conference facilitated an interdisciplinary exchange between scientists, engineers, and educators addressing the major questions encountered in the field of Plant Biomechanics. Subjects covered by the conference include: Evolution; Ecology; Mechanoreception; Cell Walls; Genetic Modification; Applied Biomechanics of Whole Plants, Plant Products, Fibers & Composites; Fluid Dynamics; Wood & Trees; Fracture Mechanics; Xylem Pressure & Water Transport; Modeling; and Introducing Plant Biomechanics in Secondary School Education.

The Effects of Cooperative Learning Strategies on Vocabulary Skills of 4th Grade Students

ERIC Educational Resources Information Center

Bilen, Didem; Tavil, Zekiye Müge

2015-01-01

This study was carried out to investigate the effects of cooperative learning strategies on the vocabulary skills of 4th grade students. The study was also designed to ascertain the attitudes of the students in the experimental group towards cooperative learning. Out of 96 4th grade students enrolled in the private school where the study took…

4th integrated transportation management systems (ITMS) conference : white papers

DOT National Transportation Integrated Search

2001-07-01

This report provides the technical papers prepared for the 4th Integrated Transportation Management Systems (ITMS) Conference held in Newark, New Jersey on July 15-18, 2001. The Conference was sponsored by the Transportation Research Board (TRB), the...

11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry

PubMed Central

Sousa, Maria Emília; Araújo, Maria João; do Vale, Maria Luísa; Andrade, Paula B.; Branco, Paula; Gomes, Paula; Moreira, Rui; Pinho e Melo, Teresa M.V.D.; Freitas, Victor

2016-01-01

For the first time under the auspices of Sociedade Portuguesa de Química, the competences of two important fields of Chemistry are brought together into a single event, the 11st National Organic Chemistry Meeting and the the 4th National Medicinal Chemistry Meeting, to highlight complementarities and to promote new synergies. Abstracts of plenary lectures, oral communications, and posters presented during the meeting are collected in this report. PMID:27102166

9 CFR 391.4 - Laboratory services rate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Laboratory services rate. 391.4 Section 391.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FEES AND CHARGES FOR INSPECTION SERVICES...

[How do hospital clinical laboratories and laboratory testing companies cooperate and build reciprocal relations?].

PubMed

Kawano, Seiji

2014-12-01

As the 2nd Joint Symposium of the Japanese Society of Laboratory Medicine and the Japanese Association of Laboratory Pathologists, the symposium on clinical test out-sourcing and branch laboratories was held at the 60th General Meeting of the Japanese Society of Laboratory Medicine on November 2nd, 2013 in Kobe. For the symposium, we conducted a questionnaire survey on the usage of clinical test out-sourcing and the introduction of branch laboratories to clinical laboratories of Japanese university hospitals, both private and public, between July 25th and August 20th, 2013. Seventy-two hospitals responded to the questionnaire survey, consisting of 41 public medical school hospitals and 31 private ones. According to the survey, the selection of each clinical test for out-sourcing was mainly determined by the capacities of hospital clinical laboratories and their equipment, as well as the profitability of each test. The main concerns of clinical laboratory members of university hospitals involved the continuity of measurement principles, traceability, and standardization of reference values for each test. They strongly requested the interchangeability and computerization of test data between laboratory testing companies. A branch laboratory was introduced to six hospitals, all of which were private medical college hospitals, out of 72 university hospitals, and eight of the other hospitals were open to its introduction. The merits and demerits of introducing a branch laboratory were also discussed. (Review).

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

PubMed

Zander, Ryan A; Vijay, Rahul; Pack, Angela D; Guthmiller, Jenna J; Graham, Amy C; Lindner, Scott E; Vaughan, Ashley M; Kappe, Stefan H I; Butler, Noah S

2017-11-14

Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria. To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T cells in experimental models. We found that populations of both Th1- and Tfh-like Plasmodium-specific memory CD4 T cells persist. Unexpectedly, Th1-like memory cells exhibit phenotypic and functional features of Tfh cells during recall and provide potent B cell help and protection following transfer, characteristics that are enhanced following ligation of the T cell co-stimulatory receptor OX40. Our findings delineate critical functional attributes of Plasmodium-specific memory CD4 T cells and identify a host-specific factor that can be targeted to improve resolution of acute malaria and provide durable, long-term protection against Plasmodium parasite re-exposure. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

General Chemistry Collection for Students (CD-ROM), Abstract of Special Issue 16, 4th Edition

NASA Astrophysics Data System (ADS)

2000-07-01

The General Chemistry Collection contains both new and previously published JCE Software programs that are intended for use by introductory-level chemistry students. These peer-reviewed programs for Macintosh and for Windows are available on a single CD-ROM for convenient distribution to and access by students, and the CD may be adopted for students to purchase as they would a textbook. General Chemistry Collection covers a broad range of topics providing students with interesting information, tutorials, and simulations that will be useful to them as they study chemistry for the first time. There are 22 programs included in the General Chemistry Collection 4th Edition. Their titles and the general chemistry topics they cover are listed in Table 1. Features in This Edition General Chemistry Collection, 4th edition includes:

• Lessons for Introductory Chemistry and INQUAL-S, two new programs not previously published by JCE Software (abstracts appear below)
• Writing Electron Dot Structures (1) and Viscosity Measurement: A Virtual Experiment for Windows (2), two programs published individually by JCE Software
• Periodic Table Live! LE, a limited edition of Periodic Table Live!, 2nd Edition (3) (this replaces Chemistry Navigator (4) and Illustrated Periodic Table (5))
• Many of the programs from previous editions (6)1

75 FR 34374 - Safety Zone; Stockton Ports Baseball Club/City of Stockton, 4th of July Fireworks Display...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...-AA00 Safety Zone; Stockton Ports Baseball Club/City of Stockton, 4th of July Fireworks Display... July 4th fireworks display. This safety zone is established to ensure the safety of participants and... will sponsor the Stockton Ports Baseball Club/City of Stockton 4th of July Fireworks Display on July 4...

Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma.

PubMed

Shi, Yu-heng; Shi, Guo-chao; Wan, Huan-ying; Jiang, Li-hua; Ai, Xiang-yan; Zhu, Hai-xing; Tang, Wei; Ma, Jia-yun; Jin, Xiao-yan; Zhang, Bo-ying

2011-07-05

Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4(+) T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells in patients with allergic asthma. Twenty-two patients with mild asthma, 17 patients with moderate to severe asthma and 20 healthy donors were enrolled. All patients were allergic to house dust mites. Plasma total IgE, pulmonary function and Asthma Control Questionnaire were assessed. The proportions of peripheral blood Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells were determined by flow cytometry. The expression of cytokines in plasma and in the culture supernatant of peripheral blood mononuclear cells was determined by enzyme linked, immunosorbent assay. The frequency of blood Th2 cells and IL-4 levels in plasma and culture supernatant of peripheral blood mononuclear cells were increased in all patients with allergic asthma. The frequency of Th17 cells and the plasma and culture supernatant levels of IL-17 were increased, whereas the frequency of CD4(+)CD25(+) Treg cells and plasma IL-10 levels were decreased in patients with moderate to severe asthma. Dermatophagoides pteronyssinus specific IgE levels were positively correlated with the percentage of blood Th2 cells and plasma IL-4 levels. Forced expiratory volume in the first second was negatively correlated with the frequency of Th17 cells and plasma IL-17 levels, and positively correlated with the frequency of Treg cells. However, mean Asthma Control Questionnaire scores were positively correlated with the frequency of Th17 cells and plasma IL-17 levels, and negatively correlated with the frequency of Treg cells. Imbalances in Th1/Th2 and Th17/Treg were found in patients with allergic asthma. Furthermore, elevated Th17 cell responses, the absence of Tregs and an imbalance in Th17/Treg levels were associated with moderate to severe asthma.

[Anti-feeding activity of total ginsenoside from Panax ginseng to 4th-instar Mythimna separata larvae].

PubMed

Tan, Shi-qiang; Ma, Lin; Xu, Yong-hua; Lei, Feng-jie; Zhang, Ai-hua; Zhang, Lian-xue

2015-07-01

This paper is in order to study the anti-feeding and growth inhibition activity of toatal ginsenoside of ginseng stems and leaves against 4th-instar Mythimna separata larvae. Simulating natural growing condition indoors, on the base, To study the anti-feeding and growth inhibition activity of toatal ginsenoside against 4th-instar M. separata larvae by leaf disc test. The toatal ginsenoside appeared to be of significant antifeeding activity against 4th-instar M. separata larvae. The 4th-instar M. separata larvae fed on the leaves of Sorghum bicolor treated with 20, 10, 5 g · L(-1) toatal ginsenoside. At 8 h, non-selective anti-feeding rate were 88.67%, 64.40% and 47.36%, and selective anti-feeding rate were 62.49% , 44.29% and 34.19%; Compared with the photographic, The toatal ginsenoside conld make the development period had prolonged 13h in treated group. The toatal ginsenoside had significant inhibition effect on feeding and growth and development against 4th-instar M. separata larvae, and inhibition effect increases as the increase of concentration ginsenoside.

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends.

PubMed

Bertolaccini, Maria Laura; Amengual, Olga; Andreoli, Laura; Atsumi, Tatsuya; Chighizola, Cecilia B; Forastiero, Ricardo; de Groot, Philip; Lakos, Gabriella; Lambert, Marc; Meroni, Pierluigi; Ortel, Thomas L; Petri, Michelle; Rahman, Anisur; Roubey, Robert; Sciascia, Savino; Snyder, Melissa; Tebo, Anne E; Tincani, Angela; Willis, Rohan

2014-09-01

Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil). Copyright © 2014 Elsevier B.V. All rights reserved.

9 CFR 391.4 - Laboratory services rate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Laboratory services rate. 391.4 Section 391.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... dividing the Office of Public Health Science (OPHS) previous fiscal year's regular direct pay by OPHS...

9 CFR 391.4 - Laboratory services rate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Laboratory services rate. 391.4 Section 391.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... dividing the Office of Public Health Science (OPHS) previous fiscal year's regular direct pay by OPHS...

9 CFR 391.4 - Laboratory services rate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Laboratory services rate. 391.4 Section 391.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... dividing the Office of Public Health Science (OPHS) previous fiscal year's regular direct pay by OPHS...

Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function.

PubMed

Karim, Ahmad Faisal; Reba, Scott M; Li, Qing; Boom, W Henry; Rojas, Roxana E

2017-09-01

We have recently demonstrated that mycobacterial ligands engage Toll like receptor 2 (TLR2) on CD4 + T cells and up-regulate T-cell receptor (TCR) triggered Th1 responses in vitro and in vivo. To better understand the role of T-cell expressed TLR2 on CD4 + T-cell differentiation and function, we conducted a gene expression analysis of murine naïve CD4 + T-cells stimulated in the presence or absence of TLR2 co-stimulation. Unexpectedly, naïve CD4 + T-cells co-stimulated via TLR2 showed a significant up-regulation of Il9 mRNA compared to cells co-stimulated via CD28. Under TH9 differentiation, we observed up-regulation of TH9 differentiation, evidenced by increases in both percent of IL-9 secreting cells and IL-9 in culture supernatants in the presence of TLR2 agonist both in polyclonal and Ag85B cognate peptide specific stimulations. Under non-polarizing conditions, TLR2 engagement on CD4 + T-cells had minimal effect on IL-9 secretion and TH9 differentiation, likely due to a prominent effect of TLR2 signaling on IFN-γ secretion and TH1 differentiation. We also report that, TLR2 signaling in CD4 + T cells increased expression of transcription factors BATF and PU.1, known to positively regulate TH9 differentiation. These results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Expression of tyrosine hydroxylase in CD4+ T cells contributes to alleviation of Th17/Treg imbalance in collagen-induced arthritis.

PubMed

Wang, Xiao-Qin; Liu, Yan; Cai, Huan-Huan; Peng, Yu-Ping; Qiu, Yi-Hua

2016-12-01

Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. However, the role of T cell-expressed TH in rheumatoid arthritis (RA) is less clear. Herein, we aimed to show the contribution of TH expression by CD4 + T cells to alleviation of helper T (Th)17/regulatory T (Treg) imbalance in collagen-induced arthritis (CIA), a mouse model of RA. CIA was prepared by intradermal injection of collagen type II (CII) at tail base of DBA1/J mice. Expression of TH in the spleen and the ankle joints was measured by real-time polymerase chain reaction and Western blot analysis. Percentages of TH-expressing Th17 and Treg cells in splenic CD4 + T cells were determined by flow cytometry. Overexpression and knockdown of TH gene in CD4 + T cells were taken to evaluate effects of TH on Th17 and Treg cells in CIA. TH expression was upregulated in both the inflamed tissues (spleen and ankle joints) and the CD4 + T cells of CIA mice. In splenic CD4 + T cells, the cells expressing TH were increased during CIA. These cells that expressed more TH in CIA were mainly Th17 cells rather than Treg cells. TH gene overexpression in CD4 + T cells from CIA mice reduced Th17 cell percentage as well as Th17-related transcription factor and cytokine expression and secretion, whereas TH gene knockdown enhanced the Th17 cell activity. In contrast, TH gene overexpression increased Treg-related cytokine expression and secretion in CD4 + T cells of CIA mice, while TH gene knockdown decreased the Treg cell changes. Collectively, these findings show that CIA induces TH expression in CD4 + T cells, particularly in Th17 cells, and suggest that the increased TH expression during CIA represents an anti-inflammatory mechanism.

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

PubMed

Pelly, Victoria S; Coomes, Stephanie M; Kannan, Yashaswini; Gialitakis, Manolis; Entwistle, Lewis J; Perez-Lloret, Jimena; Czieso, Stephanie; Okoye, Isobel S; Rückerl, Dominik; Allen, Judith E; Brombacher, Frank; Wilson, Mark S

2017-06-05

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4 + Foxp3 + regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex-T reg Th2 cells develop and contribute to type-2 immunity. Using multigene reporter and fate-reporter systems, we demonstrate that a significant proportion of Th2 cells derive from Foxp3 + cells after Heligmosomoides polygyrus infection and airway allergy. Ex-Foxp3 Th2 cells exhibit characteristic Th2 effector functions and provide immunity to H. polygyrus Through selective deletion of Il4ra on Foxp3 + cells, we further demonstrate IL-4 is required for the development of ex-Foxp3 Th2 cells. Collectively, our findings indicate that converting T reg cells into Th2 cells could concomitantly enhance Th2 cells and limit T reg cell-mediated suppression. © 2017 Pelly et al.

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

PubMed Central

Coomes, Stephanie M.; Kannan, Yashaswini; Entwistle, Lewis J.; Perez-Lloret, Jimena; Czieso, Stephanie

2017-01-01

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4+Foxp3+ regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex–T reg Th2 cells develop and contribute to type-2 immunity. Using multigene reporter and fate-reporter systems, we demonstrate that a significant proportion of Th2 cells derive from Foxp3+ cells after Heligmosomoides polygyrus infection and airway allergy. Ex-Foxp3 Th2 cells exhibit characteristic Th2 effector functions and provide immunity to H. polygyrus. Through selective deletion of Il4ra on Foxp3+ cells, we further demonstrate IL-4 is required for the development of ex-Foxp3 Th2 cells. Collectively, our findings indicate that converting T reg cells into Th2 cells could concomitantly enhance Th2 cells and limit T reg cell–mediated suppression. PMID:28507062

Normal limits of pediatric Frank lead electrocardiograms. Differences in data obtained in 4th or 5th intercostal spaces.

PubMed

Robert, A; Derwael-Barchy, C; Fesler, R; Brasseur, L A; Brohet, C R

1984-01-01

Frank lead electrocardiograms (VCGs) were recorded from 970 young subjects in order to establish normal limits for pediatric VCGs. In 245 children and 231 adolescents, the thoracic electrodes were located at the levels of the 4th and of the 5th intercostal space with subjects in supine position. Pairwise comparisons of 211 linear and angular parameters were made, using the 4th interspace as the reference. In children, there were 155 parameters with statistically significant differences and 56 parameters without significant differences between levels 4 and 5. In adolescents, corresponding figures were 158 parameters with significant differences and 53 without. Results for selected measurements showed an increase of the amplitude of Q and R waves in leads X and Y, a decrease of Q and R waves in lead Z and an increase of maximal spatial and planar QRS vectors, with the QRS loop being more anteriorly oriented by shifting the electrodes from level 4 to level 5. The mean differences in amplitude and orientation were generally small and of little practical value. However, the percentile distribution of the differences indicated that substantial changes in either direction can occur in some subjects. Thus, quantitative analysis of the pediatric Frank VCGs can be critically affected by modification of electrode placement. It is suggested that normal limits should be determined for each recording level and that criteria for analysis should be applied only to VCGs recorded at the same specified level.

77 FR 39422 - Eighth Coast Guard District Annual Safety Zones; Niceville July 4th Fireworks Show; Boggy Bayou...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

...-AA00 Eighth Coast Guard District Annual Safety Zones; Niceville July 4th Fireworks Show; Boggy Bayou... Guard will enforce a Safety Zone for the Niceville July 4th Fireworks Show in Boggy Bayou, Niceville... July 4th Fireworks Show. During the enforcement period, entry into, transiting or anchoring in the...

29. VIEW OF 4TH FLOOR'S TELEPHONE RACKS WITH CABLE TRAYS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. VIEW OF 4TH FLOOR'S TELEPHONE RACKS WITH CABLE TRAYS ABOVE. THESE ARE NEWER APPARATUS AND NOT ORIGINAL. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

1. WEST AND NORTH (OBLIQUE VIEW) SIDES, FROM ACROSS 4TH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. WEST AND NORTH (OBLIQUE VIEW) SIDES, FROM ACROSS 4TH STREET, LOOKING SOUTHEAST. - Oakland Naval Supply Center, Warehouse, North of A Street, between Fourth & Maritime Streets, Oakland, Alameda County, CA

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility shall file an updated Electric Quarterly..., file by January 31. Electric Quarterly Reports must be prepared in conformance with the Commission's...

The AMTEX Partnership{trademark}. Fourth quarter FY95 report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-09-01

The AMTEX Partnership{trademark} is a collaborative research and development program among the US Integrated Textile Industry, the Department of Energy (DOE), the national laboratories, other federal agencies and laboratories, and universities. The goal of AMTEX is to strengthen the competitiveness of this vital industry, thereby preserving and creating US jobs. The operations and program management of the AMTEX Partnership{trademark} is provided by the Program Office. This report is produced by the Program Office on a quarterly basis and provides information on the progress, operations, and project management of the partnership. Progress is reported on the following projects: computer-aided fabric evaluation;more » cotton biotechnology; demand activated manufacturing architecture; electronic embedded fingerprints; on-line process control for flexible fiber manufacturing; rapid cutting; sensors for agile manufacturing; and textile resource conservation.« less

Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine.

PubMed

Nagayama, Yuji; Mizuguchi, Hiroyuki; Hayakawa, Takao; Niwa, Masami; McLachlan, Sandra M; Rapoport, Basil

2003-04-01

Graves' hyperthyroidism has long been considered to be a Th2-type autoimmune disease because it is directly mediated by autoantibodies against the thyrotropin receptor (TSHR). However, several lines of evidence have recently challenged this concept. The present study evaluated the Th1/Th2 paradigm in Graves' disease using a recently established murine model involving injection of adenovirus expressing the TSHR (AdCMVTSHR). Coinjection with adenovirus expressing IL-4 (AdRGDCMVIL-4) decreased the ratio of Th1/Th2-type anti-TSHR Ab subclasses (IgG2a/IgG1) and suppressed the production of IFN-gamma by splenocytes in response to TSHR Ag. Importantly, immune deviation toward Th2 was accompanied by significant inhibition of thyroid-stimulating Ab production and reduction in hyperthyroidism. However, in a therapeutic setting, injection of AdRGDCMVIL-4 alone or in combination with AdCMVTSHR into hyperthyroid mice had no beneficial effect. In contrast, coinjection of adenoviruses expressing IL-12 and the TSHR promoted the differentiation of Th1-type anti-TSHR immune responses as demonstrated by augmented Ag-specific IFN-gamma secretion from splenocytes without changing disease incidence. Coinjection of adenoviral vectors expressing IL-4 or IL-12 had no effect on the titers of anti-TSHR Abs determined by ELISA or thyroid-stimulating hormone-binding inhibiting Ig assays, suggesting that Ab quality, not quantity, is responsible for disease induction. Our observations demonstrate the critical role of Th1 immune responses in a murine model of Graves' hyperthyroidism. These data may raise a cautionary note for therapeutic strategies aimed at reversing Th2-mediated autoimmune responses in Graves' disease in humans.

Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995more » commitments.« less

Quarterly coal report, October--December 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-23

The Quarterly Coal Report (QCR) provides comprehensive information about US coal production, distribution, exports, imports, receipts, prices, consumption, and stocks to a wide audience, including Congress, Federal and State agencies, the coal industry, and the general public. Coke production, consumption, distribution, imports, and exports data are also provided. The data presented in the QCR are collected and published by the Energy Information Administration (EIA) to fulfill data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 (Public Law 93-275), as amended. This report presents detailed quarterly data for October through December 1994 and aggregated quarterlymore » historical data for 1986 through the third quarter of 1994. Appendix A displays, from 1986 on, detailed quarterly historical coal imports data, as specified in Section 202 of the Energy Policy and Conservation Amendments Act of 1985 (Public Law 99-58). Appendix B gives selected quarterly tables converted to metric tons.« less

Second Quarter Hanford Seismic Report for Fiscal Year 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rohay, Alan C.; Sweeney, Mark D.; Hartshorn, Donald C.

2010-06-30

The Hanford Seismic Assessment Program (HSAP) provides an uninterrupted collection of high-quality raw and processed seismic data from the Hanford Seismic Network for the U.S. Department of Energy and its contractors. The HSAP is responsible for locating and identifying sources of seismic activity and monitoring changes in the historical pattern of seismic activity at the Hanford Site. The data are compiled, archived, and published for use by the Hanford Site for waste management, natural phenomena hazards assessments, and engineering design and construction. In addition, the HSAP works with the Hanford Site Emergency Services Organization to provide assistance in the eventmore » of a significant earthquake on the Hanford Site. The Hanford Seismic Network and the Eastern Washington Regional Network consist of 44 individual sensor sites and 15 radio relay sites maintained by the Hanford Seismic Assessment Team. The Hanford Seismic Network recorded 90 local earthquakes during the second quarter of FY 2010. Eighty-one of these earthquakes were detected in the vicinity of Wooded Island, located about eight miles north of Richland just west of the Columbia River. The Wooded Island events recorded this quarter were a continuation of the swarm events observed during the 2009 and 2010 fiscal years and reported in previous quarterly and annual reports (Rohay et al; 2009a, 2009b, 2009c, and 2010). Most of the events were considered minor (coda-length magnitude [Mc] less than 1.0) with only 1 event in the 2.0-3.0 range; the maximum magnitude event (3.0 Mc) occurred February 4, 2010 at depth 2.4 km. The average depth of the Wooded Island events during the quarter was 1.6 km with a maximum depth estimated at 3.5 km. This placed the Wooded Island events within the Columbia River Basalt Group (CRBG). The low magnitude of the Wooded Island events has made them undetectable to all but local area residents. The Hanford Strong Motion Accelerometer (SMA) network was triggered

Electric power quarterly, January-March 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1984-07-01

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. These data are published to provide meaningful, timely, objective, and accurate energy information for a wide audience including Congress, Federal and State agencies, industry, and the general public.

75 FR 33170 - Safety Zone; City of Martinez 4th of July Fireworks, Martinez, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0371] RIN 1625-AA00 Safety Zone; City of Martinez 4th of July Fireworks, Martinez, CA AGENCY: Coast Guard, DHS. ACTION... of Martinez 4th of July Fireworks, Martinez, CA. (a) Location. This temporary safety zone is...

Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells.

PubMed

Pyo, Myoung Yun; Yoon, Soo Jeong; Yu, Yeonsil; Park, Sunyoung; Jin, Mirim

2014-01-01

Allergic disease is dominated by Th2 immune responses. Interleukin (IL)-4 and IL-13, representative Th2 cytokines, play pivotal roles in the pathogenic activation of the Th2 immune response. In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-γ, or IL-12. IL-4 and IL-13 mRNA levels and luciferase activation in cells transiently transfected with IL-4 and IL-13 promoter reporter plasmids were significantly inhibited by C3G, suggesting that suppression might be, at least in part, regulated at the transcriptional level. Data from western blot and reverse transcription-polymerase chain reaction analyses of transcription factors involved in cytokine expression suggested that expression of GATA-3, but not T-bet, was downregulated in the nucleus by C3G. Taken together, our data indicate that C3G may has potential as an anti-allergic agent suppressing Th2 activation by downregulating Th2 cytokines and the GATA3 transcription factor in allergies.

Rapid stimulation of sodium intake combining aldosterone into the 4th ventricle and the blockade of the lateral parabrachial nucleus.

PubMed

Gasparini, S; Melo, M R; Leite, G F; Nascimento, P A; Andrade-Franzé, G M F; Menani, J V; Colombari, E

2017-03-27

Chronic infusion of aldosterone into the 4th ventricle (4th V) induces robust daily sodium intake, whereas acute injection of aldosterone into the 4th V produces no sodium intake. The inhibitory mechanism of the lateral parabrachial nucleus (LPBN) restrains sodium intake induced by different natriorexigenic stimuli and might affect the acute response to aldosterone into the 4th V. In the present study, 1.8% NaCl and water intake was tested in rats treated with acute injections of aldosterone into the 4th V combined with the blockade of the inhibitory mechanisms with injections of moxonidine (α 2 adrenergic/imidazoline agonist) or methysergide (a serotonergic antagonist) into the LPBN. Male Holtzman rats with stainless steel cannulas implanted in the 4th V and bilaterally in the LPBN were used. Aldosterone (250 or 500ng) into the 4th V combined with vehicle into the LPBN induced no 1.8% NaClintake compared to control (1.5±1.1 and 1.1±0.4, respectively, vs. vehicle into 4th V: 1.0±0.5ml/2h). However, aldosterone (250 or 500ng) into the 4th V combined with moxonidine (0.5nmol) into the LPBN induced strong ingestion of 1.8% NaCl (12.7±4.6 and 17.6±3.7ml/2h, respectively). Aldosterone (250ng) into the 4th V combined with methysergide (4μg) into the LPBN also induced 1.8% NaCl intake (17.6±5.4ml/2h). These data suggest that the inhibitory mechanisms of the LPBN counteract the facilitation of sodium intake produced by aldosterone injected into the 4th, restraining sodium intake in this condition. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Next Generation Hydrogen Station Composite Data Products: Retail Stations, Data through Quarter 4 of 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sprik, Sam; Kurtz, Jennifer; Ainscough, Chris

This publication includes 86 composite data products (CDPs) produced for next generation hydrogen stations, with data through the fourth quarter of 2016. These CDPs include data from retail stations only.

Next Generation Hydrogen Station Composite Data Products: Retail Stations, Data through Quarter 4 of 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sprik, Samuel; Kurtz, Jennifer M; Saur, Genevieve

This publication includes 98 composite data products (CDPs) produced for next generation hydrogen stations, with data through the fourth quarter of 2017. These CDPs include data from retail stations only.

18. DETAILED OFFSHORE VIEW OF 4TH TEE, LOOKING NORTHWEST, SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. DETAILED OFFSHORE VIEW OF 4TH TEE, LOOKING NORTHWEST, SHOWING TRANSITION FROM WOOD BENTS TO CONCRETE BENTS - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

19 CFR 159.34 - Certified quarterly rate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.34 Certified quarterly rate. (a) Countries for which quarterly rate is certified. For the currency of each of the following... York for such foreign currency for a day in that quarter: Australia, Austria, Belgium, Brazil, Canada...

Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy

PubMed Central

Shen, Jie; Li, Zhangfang; Li, Wenting; Ge, Ying; Xie, Min; Lv, Meng; Fan, Yanfei; Chen, Zhi; Zhao, Defu; Han, Yajuan

2015-01-01

To determine serum cytokine profiles in Graves' disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 GD + active TAO, 20 GD + TAO, and 10 healthy controls. Liquid chip assay was used to measure serum Th1/Th2/Th17 cytokines including IFN-γ (interferon-gamma), TNF-α (tumor necrosis factor-alpha), IL-1α (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, and IL-17 and two chemokines: RANTES (regulated upon activation, normal T cell expressed and secreted) and IP-10 (IFN-γ-induced protein 10). Serum levels of TSH (thyroid stimulating hormone) receptor autoantibodies (TRAb) were measured using an enzyme linked immunosorbent assay. Compared with healthy controls, TAO patients showed significantly elevated serum levels of IFN-γ, TNF-α, IL-1α, IL-4, IL-6, IL-17, and IP-10. Comparing active and inactive TAO, serum Th1 cytokines IFN-γ and TNF-α were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO. Serum Th17 cytokine IL-17 was elevated in GD but reduced in both active and inactive TAO. A positive correlation was found between TRAb and IFN-γ, TNF-α, IL-1α, IL-2, IL-4, and IL-6. Taken together, serum Th1/Th2/Th17 cytokines and chemokines reflect TAO disease activity and may be implicated in TAO pathogenesis. PMID:26089587

97. VIEW NORTHWEST OF 4TH FLOOR OF BUILDING 112; NOTE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

97. VIEW NORTHWEST OF 4TH FLOOR OF BUILDING 112; NOTE REMNANTS OF BEARING SUPPORTS FOR OVERHEAD BELT AND PULLEY POWER TRANSMISSION SYSTEM - Scovill Brass Works, 59 Mill Street, Waterbury, New Haven County, CT

4th floor sacking deck looking east from 1945 elevator to ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4th floor sacking deck looking east from 1945 elevator to 1913 elevator indicating spout used to load bulk grain into rail cars - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

Report of the 4th European Zebrafish Principal Investigator Meeting.

PubMed

Lopes, Susana S; Distel, Martin; Linker, Claudia; Fior, Rita; Monteiro, Rui; Bianco, Isaac H; Portugues, Ruben; Strähle, Uwe; Saúde, Leonor

2016-12-01

The European Zebrafish Principal Investigator Meeting (EZPM) is an ideal forum for group leaders using this fantastic animal model not only to discuss science but also to strengthen their interactions, to push forward technological advances, and to define guidelines for the use of this fish in research. The city of Lisbon (Portugal) was voted by the European group leaders to be the setting for the 4th EZPM, and the organizing committee, composed by Leonor Saúde (iMM Lisboa, PT), Susana Lopes (CEDOC, PT), Michael Orger (Champalimaud Foundation, PT), Rui Oliveira (ISPA, PT), and António Jacinto (CEDOC, PT), was very enthusiastic to organize a productive event. The 4th EZPM took place from March 15 to 19 at Pavilhão do Conhecimento, a Science Museum and Educational Center winner of The Great Prize FAD of Arquitecture 1999 and The Society for Environmental Graphic Design Award 2011. Over 5 days, 135 group leaders (89 men and 46 women) coming from 19 different European countries and also from the United States, Turkey, Israel, Chile, and Singapore presented and discussed their recent research achievements. In addition to the scientific oral and poster presentations, the group leaders gathered in very lively community sessions on morphants versus mutants (chaired by Didier Stainier, Max Planck Institute for Heart and Lung Research, DE), funding issues (chaired by Uwe Strahle, KIT-ITG, DE), and gender equality (chaired by Corinne Houart, KCL, United Kingdom). One of the highlights of the 4th EZPM was the guided visit to Oceanário de Lisboa, an international award-winning place that celebrates life with a stunning display of living aquatic creatures.

Quarterly Progress Report (January 1 to March 31, 1950)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brookhaven National Laboratory

This is the first of a series of Quarterly Reports. These reports will deal primarily with the progress made in our scientific program during a three months period. Those interested in matters pertaining to organization, administration, complete scientific program, personnel and other matters not directly involved in current scientific progress are referred to our Annual Progress Report which is issued in January. We have attempted to describe new information that appears significant, or of interest, to other scientists within the Atomic Energy Commission Laboratories. No effort has been made, however, to detail progress in each and every research project. Littlemore » or no reference will therefore be found to the projects in which progress during the current period is considered too inconclusive. Since our organizational structure is departmental, the work described herein is arranged in the following sequence: (1) Accelerator Project; (2) Biology Department; (3) Chemistry Department; (4) Instrumentation and Health Physic8 Department; (5) Medical Department; (6) Physics Department; and (7) Reactor Science and Engineering Department.« less

5. Double crib barn, main floor, 4th room from northeast, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Double crib barn, main floor, 4th room from northeast, southeast and southwest walls - Wilkins Farm, Barn, South side of Dove Hollow Road, 6000 feet east of State Route 259, Lost City, Hardy County, WV

Temporary Laboratory Office in Huntsville Industrial Center Building

NASA Technical Reports Server (NTRS)

1964-01-01

Temporary quarters in the Huntsville Industrial Center (HIC) building located in downtown Huntsville, Alabama, as Marshall Space Flight Center (MSFC) grew. This image shows drafting specialists from the Propulsion and Vehicle Engineering Laboratory at work in the HIC building.

Charactering baseline shift with 4th polynomial function for portable biomedical near-infrared spectroscopy device

NASA Astrophysics Data System (ADS)

Zhao, Ke; Ji, Yaoyao; Pan, Boan; Li, Ting

2018-02-01

The continuous-wave Near-infrared spectroscopy (NIRS) devices have been highlighted for its clinical and health care applications in noninvasive hemodynamic measurements. The baseline shift of the deviation measurement attracts lots of attentions for its clinical importance. Nonetheless current published methods have low reliability or high variability. In this study, we found a perfect polynomial fitting function for baseline removal, using NIRS. Unlike previous studies on baseline correction for near-infrared spectroscopy evaluation of non-hemodynamic particles, we focused on baseline fitting and corresponding correction method for NIRS and found that the polynomial fitting function at 4th order is greater than the function at 2nd order reported in previous research. Through experimental tests of hemodynamic parameters of the solid phantom, we compared the fitting effect between the 4th order polynomial and the 2nd order polynomial, by recording and analyzing the R values and the SSE (the sum of squares due to error) values. The R values of the 4th order polynomial function fitting are all higher than 0.99, which are significantly higher than the corresponding ones of 2nd order, while the SSE values of the 4th order are significantly smaller than the corresponding ones of the 2nd order. By using the high-reliable and low-variable 4th order polynomial fitting function, we are able to remove the baseline online to obtain more accurate NIRS measurements.

Atmospheric Radiation Measurement Program Climate Research Facility Operation quarterly report July 1 - September 30, 2010.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sisterson, D. L.

2010-10-26

Individual raw datastreams from instrumentation at the Atmospheric Radiation Measurement (ARM) Climate Research Facility fixed and mobile sites are collected and sent to the Data Management Facility (DMF) at Pacific Northwest National Laboratory (PNNL) for processing in near real-time. Raw and processed data are then sent approximately daily to the ARM Archive, where they are made available to users. For each instrument, we calculate the ratio of the actual number of data records received daily at the Archive to the expected number of data records. The results are tabulated by (1) individual datastream, site, and month for the current yearmore » and (2) site and fiscal year (FY) dating back to 1998. The U.S. Department of Energy (DOE) requires national user facilities to report time-based operating data. The requirements concern the actual hours of operation (ACTUAL); the estimated maximum operation or uptime goal (OPSMAX), which accounts for planned downtime; and the VARIANCE [1-(ACTUAL/OPSMAX)], which accounts for unplanned downtime. The OPSMAX time for the fourth quarter of FY2010 for the Southern Great Plains (SGP) site is 2097.60 hours (0.95 2208 hours this quarter). The OPSMAX for the North Slope of Alaska (NSA) locale is 1987.20 hours (0.90 2208) and for the Tropical Western Pacific (TWP) locale is 1876.80 hours (0.85 2208). The first ARM Mobile Facility (AMF1) deployment in Graciosa Island, the Azores, Portugal, continues, so the OPSMAX time this quarter is 2097.60 hours (0.95 x 2208). The differences in OPSMAX performance reflect the complexity of local logistics and the frequency of extreme weather events. It is impractical to measure OPSMAX for each instrument or datastream. Data availability reported here refers to the average of the individual, continuous datastreams that have been received by the Archive. Data not at the Archive are caused by downtime (scheduled or unplanned) of the individual instruments. Therefore, data availability is directly

A thermodynamic study of the gaseous thorium carbides, ThC, ThC2, ThC3, ThC4, ThC5, and ThC6

NASA Astrophysics Data System (ADS)

Gupta, Satish K.; Gingerich, Karl A.

1980-02-01

Six gaseous carbides of thorium, ThCn(n=1-6), have been identified in a Knudsen effusion mass spectrometric investigation of the vapor phase above a thorium-uranium-rhodium-graphite system at high temperatures. The partial pressures of the thorium containing species were measured as a function of temperature in the 2300-2700 °K range. Third law enthalpies for the reactions Th(g)+nC(graphite) =ThCn, n=1 to 6, and of various other homogeneous and heterogeneous reactions were evaluated. By combining the experimental enthalpies with appropriate thermodynamic data taken from literature, the following values for the atomization energies ΔH °at,298, and standard heats of formation ΔH °f,298 of thorium carbides have been derived:

Fine PM2.5 around July 4th

EPA Pesticide Factsheets

Data used in these analyses was obtained from publically-available sources, specifically the EPA's AirNow website (https://www.epa.gov/outdoor-air-quality-data). The dataset provided includes the subset of data from AirNow that was used in our analyses.This dataset is associated with the following publication:Dickerson, A., A. Benson, B. Buckley, and E. Chan. Concentrations of individual fine particulate matter components in the United States around July 4th. Air Quality, Atmosphere & Health. Springer Netherlands, NETHERLANDS, 1-10, (2016).

TID Test Results for 4th Generation iPad(TradeMark)

NASA Technical Reports Server (NTRS)

Guertin, S. M.; Allen, G. R.; McClure, S. S.; LaBel, K. A.

2013-01-01

TID testing of 4th generation iPads is reported. Of iPad subsystems, results indicate that the charging circuitry and display drivers fail at lowest TID levels. Details of construction are investigated for additional testing of components.

29. 4TH STREET FROM NEAR ITS INTERSECTION WITH J STREET, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. 4TH STREET FROM NEAR ITS INTERSECTION WITH J STREET, LOOKING NORTH, WITH WAREHOUSE 333 AT LEFT AND WAREHOUSES 433, 432 & 431 AT RIGHT. - Oakland Naval Supply Center, Maritime Street at Seventh Street, Oakland, Alameda County, CA

Electric power quarterly, July-September 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-02-04

The Electric Power Quarterly (EPQ) provides information on electric utilities at the plant level. The information concerns the following: cost, quantity, and quality of fossil fuel receipts; net generation; fuel consumption; and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. In this report, data collected on Form EIA-759 regarding electric utilities' net generation, fuel consumption, and fuel stocks are presented on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Form 423 are presented on a plant-by-plant basis. The EPQ presents a quarterly summary of disturbances andmore » unusual occurrences affecting the electric power industry collected by the Office of International Affairs and Energy Emergencies (IE) on Form IE-417.« less

4. Exterior view of Systems Integration Laboratory Building (T28), looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Exterior view of Systems Integration Laboratory Building (T-28), looking northwest. - Air Force Plant PJKS, Systems Integration Laboratory, Systems Integration Laboratory Building, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

2nd Quarter Transportation Report FY 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gregory, L.

2014-07-01

This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the second quarter of fiscal year (FY) 2014 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. This report also includes annual summaries for FY 2014 in Tables 4 and 5. Tabular summaries are provided which includemore » the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report do not include minor volumes of non-radioactive materials that were approved for disposal. Volume reports showing cubic feet (ft3) generated using the Low-Level Waste Information System may vary slightly due to differing rounding conventions.« less

Magendie and Luschka: Holes in the 4th ventricle.

PubMed

Engelhardt, Eliasz

2016-01-01

Cerebrospinal fluid (CSF) is a complex liquid formed mainly by the choroid plexuses. After filling the ventricular system where it circulates, CSF flows out to the subarachnoid spaces through openings in the 4 th ventricle. Following numerous studies on CSF pathways, these openings were first discovered in the 19 th century by two notable researchers, François Magendie and Hubert von Luschka, who described the median and lateral openings subsequently named after them. Even after the studies of Axel Key and Gustav Magnus Retzius confirming these openings, their existence was questioned by many anatomists, yet acknowledged by others. Finally gaining the acceptance of all, recognition of the holes endures to the present day. Interest in these openings may be attributed to the several congenital or acquired pathological conditions that may affect them, usually associated with hydrocephalus. We report some historical aspects of these apertures and their discoverers.

4th level of 1913 elevator indicating sacking scale, part of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4th level of 1913 elevator indicating sacking scale, part of the bagging system and nate to the sewing machine. Discharge spout for the grain bin to the left - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

Immobilization of Alkali Metal Fluorides via Recrystallization in a Cationic Lamellar Material, [Th(MoO4)(H2O)4Cl]Cl·H2O.

PubMed

Lin, Jian; Bao, Hongliang; Qie, Meiying; Silver, Mark A; Yue, Zenghui; Li, Xiaoyun; Zhu, Lin; Wang, Xiaomei; Zhang, Linjuan; Wang, Jian-Qiang

2018-06-05

Searching for cationic extended materials with a capacity for anion exchange resulted in a unique thorium molybdate chloride (TMC) with the formula of [Th(MoO 4 )(H 2 O) 4 Cl]Cl·H 2 O. The structure of TMC is composed of zigzagging cationic layers [Th(MoO 4 )(H 2 O) 4 Cl] + with Cl - as interlamellar charge-balancing anions. Instead of performing ion exchange, alkali thorium fluorides were formed after soaking TMC in AF (A = Na, K, and Cs) solutions. The mechanism of AF immobilization is elucidated by the combination of SEM-EDS, PXRD, FTIR, and EXAFS spectroscopy. It was observed that four water molecules coordinating with the Th 4+ center in TMC are vulnerable to competition with F - , due to the formation of more favorable Th-F bonds compared to Th-OH 2 . This leads to a single crystal-to-polycrystalline transformation via a pathway of recrystallization to form alkali thorium fluorides.

Navistar eStar Vehicle Performance Evaluation - 4th Quarter 2012; Energy Efficiency & Renewable Energy (EERE), Vehicle Technologies Office (VTO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2013-05-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Navistar will build and deploy all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

Reading Development and Achievement of 4th-Grade Hmong Students

ERIC Educational Resources Information Center

Mahowald, Megan; Loughnane, Megan

2016-01-01

Researchers and practitioners alike have noted that Hmong students in the United States do not achieve as well as their monolingual peers and other bilingual students. The current mixed-methods study is designed to describe reading development and achievement of 4th-grade Hmong students in one large, urban school district. This study explores the…

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

PubMed

Duechting, Andrea; Przybyla, Anna; Kuerten, Stefanie; Lehmann, Paul V

2017-09-12

During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively. Traditionally, these cytokines are measured within 6 h in flow cytometry. We show here that 6 h of stimulation is sufficient to detect peptide-induced production of IFN-γ, but 24 h are required to reveal the full frequency of protein antigen-specific Th1 cells. Also the detection of IL-2 producing Th1 cells requires 24 h stimulation cultures. Measurements of IL-4 producing Th2 cells requires 48-h cultures and 96 h are required for frequency measurements of IL-5 and IL-17 secreting T cells. Therefore, accounting for the differential secretion kinetics of these cytokines is critical for the accurate determination of the frequencies and ratios of antigen-specific Th1, Th2, and Th17 cells.

Microbiota of Cow’s Milk; Distinguishing Healthy, Sub-Clinically and Clinically Diseased Quarters

PubMed Central

Oikonomou, Georgios; Bicalho, Marcela Lucas; Meira, Enoch; Rossi, Rodolfo Elke; Foditsch, Carla; Machado, Vinicius Silva; Teixeira, Andre Gustavo Vieira; Santisteban, Carlos; Schukken, Ynte Hein; Bicalho, Rodrigo Carvalho

2014-01-01

The objective of this study was to use pyrosequencing of the 16S rRNA genes to describe the microbial diversity of bovine milk samples derived from clinically unaffected quarters across a range of somatic cell counts (SCC) values or from clinical mastitis, culture negative quarters. The obtained microbiota profiles were used to distinguish healthy, subclinically and clinically affected quarters. Two dairy farms were used for the collection of milk samples. A total of 177 samples were used. Fifty samples derived from healthy, culture negative quarters with a SCC of less than 20,000 cells/ml (group 1); 34 samples derived from healthy, culture negative quarters, with a SCC ranging from 21,000 to 50,000 cells/ml (group 2); 26 samples derived from healthy, culture negative quarters with a SCC greater than 50,000 cells/ml (group 3); 34 samples derived from healthy, culture positive quarters, with a SCC greater than 400,000 (group 4, subclinical); and 33 samples derived from clinical mastitis, culture negative quarters (group 5, clinical). Bacterial DNA was isolated from these samples and the 16S rRNA genes were individually amplified and pyrosequenced. All samples analyzed revealed great microbial diversity. Four bacterial genera were present in every sample obtained from healthy quarters (Faecalibacterium spp., unclassified Lachnospiraceae, Propionibacterium spp. and Aeribacillus spp.). Discriminant analysis models showed that samples derived from healthy quarters were easily discriminated based on their microbiota profiles from samples derived from clinical mastitis, culture negative quarters; that was also the case for samples obtained from different farms. Staphylococcus spp. and Streptococcus spp. were among the most prevalent genera in all groups while a general multivariable linear model revealed that Sphingobacterium and Streptococcus prevalences were associated with increased 10 log SCC. Conversely, Nocardiodes and Paenibacillus were negatively correlated, and a

4. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO EAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. INTERIOR OF BUILDING 313, SHOWING LABORATORY. VIEW TO EAST. - Rocky Mountain Arsenal, Laboratory Building, 510 feet South of December Seventh Avenue; 175 feet East of D Street, Commerce City, Adams County, CO

Electric Power Quarterly, July-September 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-01-01

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. In this report, data collected on Form EIA-759 regarding electric utilities' net generation, fuel consumption, and fuel stocks are presented on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Federal Energy Regulatory Commission (FERC) Form 423 are presented on a plant-by-plant basis.

Electric Power Quarterly, October-December 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-04-01

The Electric Power Quarterly (EPQ) provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption, and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. In this report, data collected on Form EIA-759 regarding electric utilities' net generation, fuel consumption, and fuel stocks are presented on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Federal Energy Regulatory Commission (FERC) Form 423 are presented on a plant-by-plant basis.

Laboratory hematology in the history of Clinical Chemistry and Laboratory Medicine.

PubMed

Hoffmann, Johannes J M L

2013-01-01

For the occasion of the 50th anniversary of the journal Clinical Chemistry and Laboratory Medicine (CCLM), an historic overview of papers that the journal has published in the field of laboratory hematology (LH) is presented. All past volumes of CCLM were screened for papers on LH and these were categorized. Bibliographic data of these papers were also analyzed. CCLM published in total 387 LH papers. The absolute number of LH papers published annually showed a significant increase over the years since 1985. Also the share of LH papers demonstrated a steady increase (overall mean 5%, but mean 8% over the past 4 years). The most frequent category was coagulation and fibrinolysis (23.5%). Authors from Germany contributed the most LH papers to the journal (22.7%), followed by the Netherlands and Italy (16.3 and 13.2%, respectively). Recent citation data indicated that other publications cited LH review papers much more frequently than other types of papers. The history of the journal reflects the emergence and development of laboratory hematology as a separate discipline of laboratory medicine.

77 FR 38486 - Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... 1625-AA00 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY AGENCY... safety zone on the Niagara River, Tonawanda, New York. This safety zone is intended to restrict vessels from a portion of the Niagara River during the City of Tonawanda July 4th Celebration fireworks on July...

Atmospheric Radiation Measurement program climate research facility operations quarterly report April 1 - June 30, 2007.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sisterson, D. L.

2007-07-26

Individual raw data streams from instrumentation at the Atmospheric Radiation Measurement (ARM) Program Climate Research Facility (ACRF) fixed and mobile sites are collected and sent to the Data Management Facility (DMF) at Pacific Northwest National Laboratory (PNNL) for processing in near real time. Raw and processed data are then sent daily to the ACRF Archive, where they are made available to users. For each instrument, we calculate the ratio of the actual number of data records received daily at the Archive to the expected number of data records. The results are tabulated by (1) individual data stream, site, and monthmore » for the current year and (2) site and fiscal year (FY) dating back to 1998. The U.S. Department of Energy requires national user facilities to report time-based operating data. The requirements concern the actual hours of operation (ACTUAL); the estimated maximum operation or uptime goal (OPSMAX), which accounts for planned downtime; and the VARIANCE [1 - (ACTUAL/OPSMAX)], which accounts for unplanned downtime. The OPSMAX time for the third quarter of FY 2007 for the Southern Great Plains (SGP) site is 2,074.8 hours (0.95 x 2,184 hours this quarter). The OPSMAX for the North Slope Alaska (NSA) locale is 1,965.6 hours (0.90 x 2,184), and that for the Tropical Western Pacific (TWP) locale is 1,856.4 hours (0.85 x 2,184). The OPSMAX time for the ARM Mobile Facility (AMF) is 2,074.8 hours (0.95 x 2,184). The differences in OPSMAX performance reflect the complexity of local logistics and the frequency of extreme weather events. It is impractical to measure OPSMAX for each instrument or data stream. Data availability reported here refers to the average of the individual, continuous data streams that have been received by the Archive. Data not at the Archive are caused by downtime (scheduled or unplanned) of the individual instruments. Therefore, data availability is directly related to individual instrument uptime. Thus, the average percent of

4. Photocopy of old 19th century photo showing a steam ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of old 19th century photo showing a steam engine in active use. Original photo in files of Insurance Company of North America, Philadelphia, Pa. Exact date not known. - Philadelphia Hose Company No. 1, Seventh & Filbert Streets, Philadelphia, Philadelphia County, PA

55. TOP (4TH) FLOOR OF 187380 WING LOOKING NORTH, WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. TOP (4TH) FLOOR OF 1873-80 WING LOOKING NORTH, WEST SIDE. NOTE SECTION, LEFT SIDE, MIDDLEGROUND, WHERE SMALL HIGH WINDOWS INDICATE POINT AT WHICH 1852 WING JOINS THIS WING. - Boston Manufacturing Company, 144-190 Moody Street, Waltham, Middlesex County, MA

Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories.

PubMed

Wurtz, N; Papa, A; Hukic, M; Di Caro, A; Leparc-Goffart, I; Leroy, E; Landini, M P; Sekeyova, Z; Dumler, J S; Bădescu, D; Busquets, N; Calistri, A; Parolin, C; Palù, G; Christova, I; Maurin, M; La Scola, B; Raoult, D

2016-08-01

Laboratory-acquired infections due to a variety of bacteria, viruses, parasites, and fungi have been described over the last century, and laboratory workers are at risk of exposure to these infectious agents. However, reporting laboratory-associated infections has been largely voluntary, and there is no way to determine the real number of people involved or to know the precise risks for workers. In this study, an international survey based on volunteering was conducted in biosafety level 3 and 4 laboratories to determine the number of laboratory-acquired infections and the possible underlying causes of these contaminations. The analysis of the survey reveals that laboratory-acquired infections have been infrequent and even rare in recent years, and human errors represent a very high percentage of the cases. Today, most risks from biological hazards can be reduced through the use of appropriate procedures and techniques, containment devices and facilities, and the training of personnel.

45. Master plan of 4th floor, building 1, U.S. Naval ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Master plan of 4th floor, building 1, U.S. Naval supply activities, New York, Brooklyn, New York, public works department, March 2, 1953. Drawing #BK-S1-4. Scale 1/16=1. - U.S. Navy Fleet Supply Base, Storehouse No. 1, 830 Third Avenue, Brooklyn, Kings County, NY

P(4-vinyl pyridine) hydrogel use for the removal of UO(2)(2+) and Th(4+) from aqueous environments.

PubMed

Ozay, Ozgur; Ekici, Sema; Aktas, Nahit; Sahiner, Nurettin

2011-12-01

4-vinyl pyridine (4-VP) based hydrogels with 2-hydroxyethylmetacrylate (HEMA) and magnetic composites were prepared and tested for use in the removal of UO(2)(2+) and Th(4+) ions from aqueous environments. It was found that the absorption of these metal ions from aqueous environments decreased with an increase in the amount of HEMA contained within p(4-VP-co-HEMA) hydrogels between 0.498 mmol for pure p(4-VP) and 0.027 mmol for pure p(HEMA). The characterization of the hydrogels was determined by swelling experiments, FT-IR and thermal analysis. The effects of initial metal ion concentration, hydrogel amount and the temperature of the medium on absorption of the ions were investigated. Langmuir and Freundlich isotherms were constructed for the absorption of UO(2)(2+) and Th(4+). Both isotherms demonstrated that these metal ions complied with monolayer absorption kinetics. Copyright © 2011 Elsevier Ltd. All rights reserved.

Teaching systems thinking to 4th and 5th graders using Environmental Dashboard display technology.

PubMed

Clark, Shane; Petersen, John E; Frantz, Cindy M; Roose, Deborah; Ginn, Joel; Rosenberg Daneri, Daniel

2017-01-01

Tackling complex environmental challenges requires the capacity to understand how relationships and interactions between parts result in dynamic behavior of whole systems. There has been convincing research that these "systems thinking" skills can be learned. However, there is little research on methods for teaching these skills to children or assessing their impact. The Environmental Dashboard is a technology that uses "sociotechnical" feedback-information feedback designed to affect thought and behavior. Environmental Dashboard (ED) combines real-time information on community resource use with images and words that reflect pro-environmental actions of community members. Prior research indicates that ED supports the development of systems thinking in adults. To assess its impact on children, the technology was installed in a primary school and children were passively exposed to ED displays. This resulted in no measurable impact on systems thinking skills. The next stage of this research examined the impact of actively integrating ED into lessons on electricity in 4th and 5th grade. This active integration enhanced both content-related systems thinking skills and content retention.

Teaching systems thinking to 4th and 5th graders using Environmental Dashboard display technology

PubMed Central

Clark, Shane; Frantz, Cindy M.; Roose, Deborah; Ginn, Joel; Rosenberg Daneri, Daniel

2017-01-01

Tackling complex environmental challenges requires the capacity to understand how relationships and interactions between parts result in dynamic behavior of whole systems. There has been convincing research that these “systems thinking” skills can be learned. However, there is little research on methods for teaching these skills to children or assessing their impact. The Environmental Dashboard is a technology that uses “sociotechnical” feedback–information feedback designed to affect thought and behavior. Environmental Dashboard (ED) combines real-time information on community resource use with images and words that reflect pro-environmental actions of community members. Prior research indicates that ED supports the development of systems thinking in adults. To assess its impact on children, the technology was installed in a primary school and children were passively exposed to ED displays. This resulted in no measurable impact on systems thinking skills. The next stage of this research examined the impact of actively integrating ED into lessons on electricity in 4th and 5th grade. This active integration enhanced both content-related systems thinking skills and content retention. PMID:28448586

Critical Value Reporting at Egyptian Laboratories.

PubMed

Mosallam, Rasha; Ibrahim, Samaa Zenhom

2015-06-12

To examine critical value reporting policies and practices and to identify critical value ranges for selected common laboratory assays at inpatient division of laboratories of Alexandria hospitals. A cross-sectional descriptive study design was used. Subjects were from inpatient division of all laboratories of Alexandria hospitals (40 laboratories). Data were collected using a questionnaire composed of 4 sections. The first section explored hospital and laboratory characteristics. The second section assessed policies and procedures of critical value reporting. The third section explored the reporting process. The fourth section explored critical value ranges for selected common laboratory assays. Written procedure for reporting of critical values was present in 77.5% of laboratories and a comprehensive list of critical values in 72.55%. For laboratories having a critical value list, the number of tests in the list ranged from 7 to 40. Three-fifths of laboratories had a policy for assessing the timeliness of reporting and 3 quarters stated that the laboratory policy requires feedback (60.0% and 75.0%, respectively). The hospital laboratory physician was responsible for critical value reporting followed by the laboratory technician (75.0% and 50.0%, respectively). The call is received mainly by nurses and physicians ordering the test (67.5% and 55.0%, respectively) and the channel of reporting is mainly the telephone or through sending test report to the ward (67.5% and 50.0%, respectively). Wireless technologies are used in reporting in only 10.0% of hospitals. The cutoff limits for reporting different assays showed considerable interlaboratory variation. Critical value policies and practices showed interinstitutional variation with deficiencies in some reporting practices. Selection of critical assays for notification and setting the limits of notification exhibited wide variation as well.

Registration of High Angular Resolution Diffusion MRI Images Using 4th Order Tensors⋆

PubMed Central

Barmpoutis, Angelos; Vemuri, Baba C.; Forder, John R.

2009-01-01

Registration of Diffusion Weighted (DW)-MRI datasets has been commonly achieved to date in literature by using either scalar or 2nd-order tensorial information. However, scalar or 2nd-order tensors fail to capture complex local tissue structures, such as fiber crossings, and therefore, datasets containing fiber-crossings cannot be registered accurately by using these techniques. In this paper we present a novel method for non-rigidly registering DW-MRI datasets that are represented by a field of 4th-order tensors. We use the Hellinger distance between the normalized 4th-order tensors represented as distributions, in order to achieve this registration. Hellinger distance is easy to compute, is scale and rotation invariant and hence allows for comparison of the true shape of distributions. Furthermore, we propose a novel 4th-order tensor re-transformation operator, which plays an essential role in the registration procedure and shows significantly better performance compared to the re-orientation operator used in literature for DTI registration. We validate and compare our technique with other existing scalar image and DTI registration methods using simulated diffusion MR data and real HARDI datasets. PMID:18051145

Laboratory Findings Suggesting an Association Between BoHV-4 and Bovine Abortions in Southern Belgium.

PubMed

Delooz, L; Czaplicki, G; Houtain, J Y; Dal Pozzo, F; Saegerman, C

2017-08-01

Abortions cause heavy economic losses for the bovine sector. The use of a standardized panel of analyses covering a large spectrum of pathogens responsible of abortion in cattle allowed demonstrating the direct involvement of at least one pathogen in 57% of analysed abortions in the southern part of Belgium. This result suggests a margin of improvement in the diagnostic efficacy. In order to evaluate the interest to broaden the list of pathogens included in the panel of analyses, the implication of bovine herpesvirus 4 (BoHV-4) in abortion was assessed by two different studies. In the first study, coupled serology was performed after abortion on 714 dams to identify specific seroconversion against BoHV-4. The overall seroconversion in cows was 19.5%, with a higher frequency in primiparous compared to multiparous females. In addition, the type of breed (beef cattle) and the time period from the fourth quarter 2008 until the last quarter 2009 were significantly related to the seroconversion of cows. The second study investigated the virus ability to infect the foetus. In this study, 368 cases of bovine abortions were specifically tested for BoHV-4, using PCR on foetus tissues and ELISA on dam and foetus sera. The results showed a maternal seroprevalence of 64.7%, a foetal seroprevalence of 0.8% and a PCR prevalence in foetuses of 1.1%, demonstrating the ability of BoHV-4 to infect the foetus. © 2016 Blackwell Verlag GmbH.

Identification of 4th intercostal space using sternal notch to xiphoid length for accurate electrocardiogram lead placement.

PubMed

Day, Kevin; Oliva, Isabel; Krupinski, Elizabeth; Marcus, Frank

2015-01-01

Precordial ECG lead placement is difficult in obese patients with increased chest wall soft tissues due to inaccurate palpation of the intercostal spaces. We investigated whether the length of the sternum (distance between the sternal notch and xiphoid process) can accurately predict the location of the 4th intercostal space, which is the traditional location for V1 lead position. Fifty-five consecutive adult chest computed tomography examinations were reviewed for measurements. The sternal notch to right 4th intercostal space distance was 67% of the sternal notch to xiphoid process length with an overall correlation of r=0.600 (p<0.001). The above measurement may be utilized to locate the 4th intercostal space for accurate placement of the precordial electrodes in adults in whom the 4th intercostal space cannot be found by physical exam. Copyright © 2015 Elsevier Inc. All rights reserved.

4. Photocopy of early 20th century photo of the bridge. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of early 20th century photo of the bridge. Donated to HAER for its collection at the Library of Congress; donation courtesy of the Erie Railroad Company. - Erie Railway, Moodna Creek Viaduct, Moodna Creek, Orrs Mill Road, Salisbury Mills, Orange County, NY

Th40 cells (CD4+CD40+ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells

PubMed Central

Vaitaitis, Gisela M.; Yussman, Martin G.; Waid, Dan M.; Wagner, David H.

2017-01-01

CD40-CD154 interaction is critically involved in autoimmune diseases, and CD4 T cells play a dominant role in the Experimental Autoimmune Encephalomyelitis (EAE) model of Multiple Sclerosis (MS). CD4 T cells expressing CD40 (Th40) are pathogenic in type I diabetes but have not been evaluated in EAE. We demonstrate here that Th40 cells drive a rapid, more severe EAE disease course than conventional CD4 T cells. Adoptively transferred Th40 cells are present in lesions in the CNS and are associated with wide spread demyelination. Primary Th40 cells from EAE-induced donors adoptively transfer EAE without further in-vitro expansion and without requiring the administration of the EAE induction regimen to the recipient animals. This has not been accomplished with primary, non-TCR-transgenic donor cells previously. If co-injection of Th40 donor cells with Freund’s adjuvant (CFA) in the recipient animals is done, the disease course is more severe. The CFA component of the EAE induction regimen causes generalized inflammation, promoting expansion of Th40 cells and infiltration of the CNS, while MOG-antigen shapes the antigen-specific TCR repertoire. Those events are both necessary to precipitate disease. In MS, viral infections or trauma may induce generalized inflammation in susceptible individuals with subsequent disease onset. It will be important to further understand the events leading up to disease onset and to elucidate the contributions of the Th40 T cell subset. Also, evaluating Th40 levels as predictors of disease onset would be highly useful because if either the generalized inflammation event or the TCR-honing can be interrupted, disease onset may be prevented. PMID:28192476

78 FR 59093 - Quarterly Rail Cost Adjustment Factor

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

...)] Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2013 rail cost adjustment factor (RCAF) and cost index filed by the Association of American Railroads. The fourth quarter 2013 RCAF...

U.S. Dietary and Physical Activity Guideline Knowledge and Corresponding Behaviors among 4th and 5th Grade Students: A Multi-Site Pilot Study

ERIC Educational Resources Information Center

Bea, Jennifer W.; Martinez, Stephanie; Armstrong-Florian, Traci; Farrell, Vanessa; Martinez, Cathy; Whitmer, Evelyn; Hartz, Vern; Blake, Samuel; Nicolini, Ariana; Misner, Scottie

2014-01-01

Knowledge of U.S. dietary and physical activity recommendations and corresponding behaviors were surveyed among 4th and 5th graders in five Arizona counties to determine the need for related education in SNAP-Ed eligible schools. A <70% target response rate was the criterion. Participants correctly identified recommendations for: fruit, 20%;…

5 CFR 332.311 - Quarterly examinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Quarterly examinations. 332.311 Section... AND SELECTION THROUGH COMPETITIVE EXAMINATION Period of Competition and Eligibility Acceptance of Applications After Closing Date of Examinations § 332.311 Quarterly examinations. (a) A 10-point preference...

Electric Power Quarterly, January-March 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-07-21

The ''Electric Power Quarterly (EPQ)'' provides information on electric utilities at the plant level. The information concerns the following: cost, quantity, and quality of fossil fuel receipts; net generation; fuel consumption; and fuel stocks. The ''EPQ'' contains monthly data and quarterly totals for the reporting quarter. In this report, data collected on Form EIA-759 regarding electric utilities' net generation, fuel consumption, and fuel stocks are presented on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Federal Energy Regulatory Commission (FERC) Form 423 are presented on a plant-by-plant basis.

10 CFR 34.69 - Records of quarterly inventory.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INDUSTRIAL RADIOGRAPHIC OPERATIONS Recordkeeping Requirements § 34.69 Records of quarterly inventory. (a) Each licensee shall maintain records of the quarterly inventory of sealed sources and of devices... 10 Energy 1 2010-01-01 2010-01-01 false Records of quarterly inventory. 34.69 Section 34.69 Energy...

STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge

PubMed Central

Dulek, Daniel E.; Newcomb, Dawn C.; Toki, Shinji; Goliniewska, Kasia; Cephus, Jacqueline; Reiss, Sara; Bates, John T.; Crowe, James E.; Boyd, Kelli L.; Moore, Martin L.; Zhou, Weisong

2014-01-01

ABSTRACT Immune-mediated lung injury is a hallmark of lower respiratory tract illness caused by respiratory syncytial virus (RSV). STAT4 plays a critical role in CD4+ Th1 lineage differentiation and gamma interferon (IFN-γ) protein expression by CD4+ T cells. As CD4+ Th1 differentiation is associated with negative regulation of CD4+ Th2 and Th17 differentiation, we hypothesized that RSV infection of STAT4−/− mice would result in enhanced lung Th2 and Th17 inflammation and impaired lung Th1 inflammation compared to wild-type (WT) mice. We performed primary and secondary RSV challenges in WT and STAT4−/− mice and used STAT1−/− mice as a positive control for the development of RSV-specific lung Th2 and Th17 inflammation during primary challenge. Primary RSV challenge of STAT4−/− mice resulted in decreased T-bet and IFN-γ expression levels in CD4+ T cells compared to those of WT mice. Lung Th2 and Th17 inflammation did not develop in primary RSV-challenged STAT4−/− mice. Decreased IFN-γ expression by NK cells, CD4+ T cells, and CD8+ T cells was associated with attenuated weight loss and enhanced viral clearance with primary challenge in STAT4−/− mice compared to WT mice. Following secondary challenge, WT and STAT4−/− mice also did not develop lung Th2 or Th17 inflammation. In contrast to primary challenge, secondary RSV challenge of STAT4−/− mice resulted in enhanced weight loss, an increased lung IFN-γ expression level, and an increased lung RSV-specific CD8+ T cell response compared to those of WT mice. These data demonstrate that STAT4 regulates the RSV-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses to RSV challenge. IMPORTANCE STAT4 is a protein critical for both innate and adaptive immune responses to viral infection. Our results show that STAT4 regulates the immune response to primary and secondary challenge with RSV but does not restrain RSV

Myosin MyTH4-FERM structures highlight important principles of convergent evolution.

PubMed

Planelles-Herrero, Vicente José; Blanc, Florian; Sirigu, Serena; Sirkia, Helena; Clause, Jeffrey; Sourigues, Yannick; Johnsrud, Daniel O; Amigues, Beatrice; Cecchini, Marco; Gilbert, Susan P; Houdusse, Anne; Titus, Margaret A

2016-05-24

Myosins containing MyTH4-FERM (myosin tail homology 4-band 4.1, ezrin, radixin, moesin, or MF) domains in their tails are found in a wide range of phylogenetically divergent organisms, such as humans and the social amoeba Dictyostelium (Dd). Interestingly, evolutionarily distant MF myosins have similar roles in the extension of actin-filled membrane protrusions such as filopodia and bind to microtubules (MT), suggesting that the core functions of these MF myosins have been highly conserved over evolution. The structures of two DdMyo7 signature MF domains have been determined and comparison with mammalian MF structures reveals that characteristic features of MF domains are conserved. However, across millions of years of evolution conserved class-specific insertions are seen to alter the surfaces and the orientation of subdomains with respect to each other, likely resulting in new sites for binding partners. The MyTH4 domains of Myo10 and DdMyo7 bind to MT with micromolar affinity but, surprisingly, their MT binding sites are on opposite surfaces of the MyTH4 domain. The structural analysis in combination with comparison of diverse MF myosin sequences provides evidence that myosin tail domain features can be maintained without strict conservation of motifs. The results illustrate how tuning of existing features can give rise to new structures while preserving the general properties necessary for myosin tails. Thus, tinkering with the MF domain enables it to serve as a multifunctional platform for cooperative recruitment of various partners, allowing common properties such as autoinhibition of the motor and microtubule binding to arise through convergent evolution.

Urban Planning Aspects of Museum Quarters as an Architectural Medium for Creative Cities

NASA Astrophysics Data System (ADS)

Kochergina, Ekaterina

2017-10-01

Since the second half of the 20th century, urban environment has experienced significant transformation. Splash of interactivity, bottom-up initiations with development of creative sector of city economy and participatory planning, irretrievably changed the attitude to the urban medium. One of the most intensively growing field - creative industry - provided cities with numerous cultural clusters, which boosted urban economic development and social cohesion. Supported in many cases by gentrification and revitalization, these processes brought renovation of brownfield and more comprehensive approaches to urban design. Understanding of the economic benefits made city managers start an active promotion of creative clusters and their intensive integration into urban life, involving the main museums and cultural institutions. Thus, a new type of cultural clusters - Museum Quarter - appeared. Holding the position of cultural flagman in the historical heart of the city, Museum Quarters (MQs) pretend to take on an important role both in urban planning structure and in social life. Furthermore, such role usually has strong influence on the surrounding districts, in a positive or negative way. Although basic principles are still applied for all types of cultural districts, the phenomena of “Museum Quarters” due to the complexity of planning, operating and maintenance issues, stepped far above basic cultural clusters, requiring substantially new attitude to the planning of such urban entities. Five clusters were chosen for this study: MQs in Vienna, Berlin, Amsterdam, Copenhagen and the currently developing project in Budapest. The main purpose of this paper is to elaborate the principles for the practical implementation of Museum Quarters by the definition and classification of their specific urban planning aspects. The complexity of target object - Museum Quarter - and its multi-level relationships with the whole city, require from the research interdisciplinary

4th level of 1945 warehouse indicating drag conveyor. From here ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4th level of 1945 warehouse indicating drag conveyor. From here screenings were pumped from the elevator leg to this conveyor. The grains were ground, then conveyed back down to the first floor for bagging. - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

94. VIEW OF PILINGS ON SOUTHEAST SIDE, WITH 4TH TEE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

94. VIEW OF PILINGS ON SOUTHEAST SIDE, WITH 4TH TEE IN THE BACKGROUND, FACING WEST-SOUTHWEST FROM SOUTHEAST CORNER OF THE TACKLE BOX. RAMP OF PIER EXTENSION IS VISIBLE ON RIGHT - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

Improving 4th Grade Primary School Students' Reading Comprehension Skills

ERIC Educational Resources Information Center

Bulut, Aydin

2017-01-01

The aim of this study was to carry out action research to investigate reading comprehension skills when using the SQ3R reading comprehension strategy. To that end, this strategy was used for improving the reading comprehension skills of 7 primary school 4th grade students who had problems with these skills. An action plan was prepared for 3hours a…

T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

PubMed Central

Zhu, Jinfang

2015-01-01

Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during type 2 immune responses, are critical for protective immunity against infections of extracellular parasites and are responsible for asthma and many other allergic inflammatory diseases. Although many immune cell types within the myeloid lineage compartment including basophils, eosinophils and mast cells are capable of producing at least one of these cytokines, the production of these “type 2 immune response-related” cytokines by lymphoid lineages, CD4 T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) in particular, are the central events during type 2 immune responses. In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells. The similarities and differences in the differentiation of Th2 cells, IL-4-producing T follicular helper (Tfh) cells and ILC2s as well as their relationships will also be discussed. PMID:26044597

Electric Power Quarterly, January-March 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-07-01

The Electric Power Quarterly (EPQ), a new series in the EIA statistical publications, provides electric utilities' plant-level information about the cost, quantity, and quality of fossil fuel receipts, net generation, fuel consumption and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. The data presented in this report were collected and published by the EIA to fulfill its responsibilities as specified in the Federal Energy Administration Act of 1974 (P.L. 93-275). This edition of the EPQ contains monthly data for the first quarter of 1983. In this report, data collected on Form EIA-759 regarding electricmore » utilities' net generation, fuel consumption, and fuel stocks are presented for the first time on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Federal Energy Regulatory Commission (FERC) Form 423 are presented on a plant-by-plant basis.« less

Framework for leadership and training of Biosafety Level 4 laboratory workers.

PubMed

Le Duc, James W; Anderson, Kevin; Bloom, Marshall E; Estep, James E; Feldmann, Heinz; Geisbert, Joan B; Geisbert, Thomas W; Hensley, Lisa; Holbrook, Michael; Jahrling, Peter B; Ksiazek, Thomas G; Korch, George; Patterson, Jean; Skvorak, John P; Weingartl, Hana

2008-11-01

Construction of several new Biosafety Level 4 (BSL-4) laboratories and expansion of existing operations have created an increased international demand for well-trained staff and facility leaders. Directors of most North American BSL-4 laboratories met and agreed upon a framework for leadership and training of biocontainment research and operations staff. They agreed on essential preparation and training that includes theoretical consideration of biocontainment principles, practical hands-on training, and mentored on-the-job experiences relevant to positional responsibilities as essential preparation before a person's independent access to a BSL-4 facility. They also agreed that the BSL-4 laboratory director is the key person most responsible for ensuring that staff members are appropriately prepared for BSL-4 operations. Although standardized certification of training does not formally exist, the directors agreed that facility-specific, time-limited documentation to recognize specific skills and experiences of trained persons is needed.

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2010 CFR

2010-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and on GPO...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2011 CFR

2011-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2012 CFR

2012-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

26 CFR 1.461-1 - General rule for taxable year of deduction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... quarter, 1964 Apr. 1 300,000 2d quarter, 1964 July 1 300,000 3d quarter, 1964 Oct. 1 300,000 4th quarter... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www...

Natural gas imports and exports. Second quarter report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-31

The Office of Natural Gas and Petroleum Import and Export Activities prepares quarterly reports summarizing the data provided by companies authorized to import or export natural gas. Companies are required, as a condition of their authorizations, to file quarterly reports. This report is for the second quarter of 1997 (April through June).

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility as well as each non-public utility with more than a de minimis market presence shall file an updated Electric Quarterly Report with the...

18 CFR 35.10b - Electric Quarterly Reports.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Electric Quarterly... Application § 35.10b Electric Quarterly Reports. Each public utility as well as each non-public utility with more than a de minimis market presence shall file an updated Electric Quarterly Report with the...

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

PubMed

Renand, Amedee; Archila, Luis D; McGinty, John; Wambre, Erik; Robinson, David; Hales, Belinda J; Thomas, Wayne R; Kwok, William W

2015-12-01

In human subjects, allergen tolerance has been observed after high-dose allergen exposure or after completed allergen immunotherapy, which is related to the accumulation of anti-inflammatory IgG4. However, the specific T-cell response that leads to IgG4 induction during chronic allergen exposure remains poorly understood. We sought to evaluate the relationship between cat allergen-specific T-cell frequency, cat allergen-specific IgE and IgG4 titers, and clinical status in adults with cat allergy with and without cat ownership and the cellular mechanism by which IgG4 is produced. Fel d 1-, Fel d 4-, Fel d 7-, and Fel d 8-specific T-cell responses were characterized by CD154 expression after antigen stimulation. In allergic subjects without cat ownership, the frequency of cat allergen (Fel d 1 and Fel d 4)-specific TH2 (sTH2) cells correlates with higher IgE levels and is linked to asthma. Paradoxically, we observed that subjects with cat allergy and chronic cat exposure maintain a high frequency of sTH2 cells, which correlates with higher IgG4 levels and low sensitization. B cells from allergic, but not nonallergic subjects, are able to produce IgG4 after cognate interactions with sTH2 clones and Fel d 1 peptide or the Fel d 1 recombinant protein. These experiments suggest that (1) allergen-experienced B cells with the capacity to produce IgG4 are present in allergic subjects and (2) cat allergen exposure induces an IgG4 response in a TH2 cell-dependent manner. Thus IgG4 accumulation could be mediated by chronic activation of the TH2 response, which in turn drives desensitization. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. All rights reserved.

Structural study of dehydration mechanisms of NH4Th(NO3)5·9H2O

NASA Astrophysics Data System (ADS)

Knyazev, A. V.; Komshina, M. E.; Baranov, E. V.; Savushkin, I. A.; Nipruk, O. V.; Lukoyanov, A. Yu.

2017-12-01

The new pentanitrate thorium compounds NH4Th(NO3)5·nH2O were synthesized and their crystal structures were determined by X-ray diffraction analysis: space group P21/n, a = 10.5476(5), b = 14.0444(7), c = 15.5287(8) Å, β = 109.4999(7)°, Z = 4; R = 0.0246 (NH4Th(NO3)5·9H2O); space group P212121, a = 8.7039(4), b = 11.9985(6), c = 16.3531(8) Å, Z = 4; R = 0.0259 (NH4Th(NO3)5·5H2O). Features of structural changes in the dehydration were revealed. Conditions of thermal decomposition of the thorium compound were established using differential scanning calorimetry. The compound was investigated by IR spectroscopy and its bands are assigned.

Publications of the Jet Propulsion Laboratory, 1984

NASA Technical Reports Server (NTRS)

1985-01-01

The Jet Propulsion Laboratory (JPL) bibliography 39-26 describes and indexes by primary author the externally distributed technical reporting, released during calendar year 1984, that resulted from scientific and engineering work performed, or managed, by the Jet Propulsion Laboratory. Three classes of publications are included: (1) JPL Publications (82-, 83-, 84-series, etc.), in which the information is complete for a specific accomplishment; (2) articles from the quarterly Telecommunications and Data Acquisition (TDA) Program Report (42-series); and (3) articles published in the open literature.

Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting The TGFβ/Smad3 pathway.

PubMed

Luo, Zhenlong; Ji, Yudong; Tian, Dean; Zhang, Yong; Chang, Sheng; Yang, Chao; Zhou, Hongmin; Chen, Zhonghua Klaus

2018-06-08

Galectin-7 (Gal-7) has been associated with cell proliferation and apoptosis. It is known that Gal-7 antagonises TGFβ-mediated effects in hepatocytes by interacting with Smad3. Previously, we have demonstrated that Gal-7 is related to CD4+ T cells responses; nevertheless, its effect and functional mechanism on CD4+ T cells responses remain unclear. The murine CD4+ T cells were respectively cultured with Gal-7, anti-CD3/CD28 mAbs, or with anti-CD3/CD28 mAbs & Gal-7. The effects of Gal-7 on proliferation and the phenotypic changes in CD4+ T cells were assessed by flow cytometry. The cytokines from CD4+ T cells were analysed by quantitative real-time PCR. Subcellular localisation and expression of Smad3 were determined by immunofluorescence staining and Western blot, respectively. Gal-7 enhanced the proliferation of activated CD4+ T cells in a dose- and β-galactoside-dependent manner. Additionally, Gal-7 treatment did not change the ratio of Th2 cells in activated CD4+ T cells, while it increased the ratio of Th1 cells. Gal-7 also induced activated CD4+ T cells to produce a higher level of IFN-γ and TNF-α and a lower level of IL-10. Moreover, Gal-7 treatment significantly accelerated nuclear export of Smad3 in activated CD4+ T cells. These results revealed a novel role of Gal-7 in promoting proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting the TGFβ/Smad3 pathway. Copyright © 2018 Elsevier Ltd. All rights reserved.

Contamination with HIV antibody may be responsible for false positive results in specimens tested on automated platforms running HIV 4th generation assays in a region of high HIV prevalence.

PubMed

Hardie, Diana Ruth; Korsman, Stephen N; Hsiao, Nei-Yuan; Morobadi, Molefi Daniel; Vawda, Sabeehah; Goedhals, Dominique

2017-01-01

In South Africa where the prevalence of HIV infection is very high, 4th generation HIV antibody/p24 antigen combo immunoassays are the tests of choice for laboratory based screening. Testing is usually performed in clinical pathology laboratories on automated analysers. To investigate the cause of false positive results on 4th generation HIV testing platforms in public sector laboratories, the performance of two automated platforms was compared in a clinical pathology setting, firstly on routine diagnostic specimens and secondly on known sero-negative samples. Firstly, 1181 routine diagnostic specimens were sequentially tested on Siemens and Roche automated 4th generation platforms. HIV viral load, western blot and follow up testing were used to determine the true status of inconclusive specimens. Subsequently, known HIV seronegative samples from a single donor were repeatedly tested on both platforms and an analyser was tested for surface contamination with HIV positive serum to identify how suspected specimen contamination could be occurring. Serial testing of diagnostic specimens yielded 163 weakly positive or discordant results. Only 3 of 163 were conclusively shown to indicate true HIV infection. Specimen contamination with HIV antibody was suspected, based on the following evidence: the proportion of positive specimens increased on repeated passage through the analysers; viral loads were low or undetectable and western blots negative or indeterminate on problem specimens; screen negative, 2nd test positive specimens tested positive when reanalysed on the screening assay; follow up specimens (where available) were negative. Similarly, an increasing number of known negative specimens became (repeatedly) sero-positive on serial passage through one of the analysers. Internal and external analyser surfaces were contaminated with HIV serum, evidence that sample splashes occur during testing. Due to the extreme sensitivity of these assays, contamination with minute

Environmental Sciences Laboratory dedication, February 26-27, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auerbach, S.I.; Millemann, N.T.

1980-09-01

The dedication of the new Environmental Sciences Laboratory coincided with the 25th year of the establishment of the science of ecology at Oak Ridge National Laboratory. That quarter century witnessed the evolution of ecology from an obscure, backwater discipline of biology to a broadly used, everyday household word. The transition reflected broad and basic changes in our social and cultural view of the world. This was brought about as a result of the awareness developed in our society of the importance of the environment, coupled with efforts of ecologists and other environmental scientists who identified, clarified, and formulated the issuesmore » and challenges of environmental protection for both the lay public and the scientific community. In many respects, the activities in ecology at ORNL were a microcosm of the broader social scene; the particular problems of the environment associated with atomic energy needed to be defined in scientific terms and articulated in both the specific and general sense for a larger audience which was unfamiliar with the field and somewhat alien to its concepts and philosophy. The success of this effort is reflected in the existence of the new Environmental Sciences Laboratory. This dedication volume brings together the thoughts and reflections of many of these scientists whose efforts contributed in a unique and individualistic fashion not only to ORNL but also to the national identification of ecology and its importance to the achievement of our national goals. Their remarks and presentations are not only a pleasant and personally gratifying recapitulation of the past and of ORNL's contributions to ecology but also portend some of the challenges to ecology in the future.« less

Improvements in Cystic Fibrosis Quarterly Visits, Lung Function Tests, and Respiratory Cultures.

PubMed

Wooldridge, Jamie L; Mason, Susan; Brusatti, Judith; Albers, Gary M; Noyes, Blakeslee E

2015-12-01

The Cystic Fibrosis (CF) Foundation recommends patients attend clinic ≥4 times per year with 4 respiratory cultures and 2 pulmonary function tests (PFTs). However, nationally only 57.4% of patients met these guidelines in 2012. We used a quality improvement program with a goal of 75% of our patients meeting this care guideline by 2012. A 2-stage program was started in 2011. Stage 1: education of patients/caregivers on importance of quarterly visits. Stage 2: quarterly tracking system of patient appointments. Data on clinic visits, respiratory cultures, and PFTs were collected from the CF registry from January 2009 through December 2013. Statistical process control charts were used to track improvements. The average number of clinic visits increased significantly from 4.6 ± 2.3 in 2009 to 6.3 ± 4.6 in 2013 (P < .0001). The percentage of patients ages 6 through 18 completing a clinic visit, PFT, and respiratory culture per quarter increased significantly from 76.2% during 2009 to 86.4% in 2013. The percentage of patients completing ≥4 clinic visits with 4 respiratory cultures and 2 PFTs improved significantly from 47.5% in 2009 to 71.0% in 2013 (P < .0001). A tracking system of patient appointments significantly improved adherence to the care guidelines better than education alone. The multiple-stage quality improvement program we implemented may be modifiable and able to be integrated in other CF centers or other multiple disciplinary chronic illness care centers. Copyright © 2015 by the American Academy of Pediatrics.

Framework for Leadership and Training of Biosafety Level 4 Laboratory Workers

PubMed Central

Anderson, Kevin; Bloom, Marshall E.; Estep, James E.; Feldmann, Heinz; Geisbert, Joan B.; Geisbert, Thomas W.; Hensley, Lisa; Holbrook, Michael; Jahrling, Peter B.; Ksiazek, Thomas G.; Korch, George; Patterson, Jean; Skvorak, John P.; Weingartl, Hana

2008-01-01

Construction of several new Biosafety Level 4 (BSL-4) laboratories and expansion of existing operations have created an increased international demand for well-trained staff and facility leaders. Directors of most North American BSL-4 laboratories met and agreed upon a framework for leadership and training of biocontainment research and operations staff. They agreed on essential preparation and training that includes theoretical consideration of biocontainment principles, practical hands-on training, and mentored on-the-job experiences relevant to positional responsibilities as essential preparation before a person’s independent access to a BSL-4 facility. They also agreed that the BSL-4 laboratory director is the key person most responsible for ensuring that staff members are appropriately prepared for BSL-4 operations. Although standardized certification of training does not formally exist, the directors agreed that facility-specific, time-limited documentation to recognize specific skills and experiences of trained persons is needed. PMID:18976549

75 FR 38718 - Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-AA00 Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI... restrict vessels from a portion of the St. Mary's River during the Sault Sainte Marie 4th of July Fireworks... the setup and launching of fireworks in conjunction with the Sault Sainte Marie 4th of July Fireworks...

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices.

PubMed

Mazur, Steven; Holbrook, Michael R; Burdette, Tracey; Joselyn, Nicole; Barr, Jason; Pusl, Daniela; Bollinger, Laura; Coe, Linda; Jahrling, Peter B; Lackemeyer, Matthew G; Wada, Jiro; Kuhn, Jens H; Janosko, Krisztina

2016-10-03

Work in a biosafety level 4 (BSL-4) containment laboratory requires time and great attention to detail. The same work that is done in a BSL-2 laboratory with non-high-consequence pathogens will take significantly longer in a BSL-4 setting. This increased time requirement is due to a multitude of factors that are aimed at protecting the researcher from laboratory-acquired infections, the work environment from potential contamination and the local community from possible release of high-consequence pathogens. Inside the laboratory, movement is restricted due to air hoses attached to the mandatory full-body safety suits. In addition, disinfection of every item that is removed from Class II biosafety cabinets (BSCs) is required. Laboratory specialists must be trained in the practices of the BSL-4 laboratory and must show high proficiency in the skills they are performing. The focus of this article is to outline proper procedures and techniques to ensure laboratory biosafety and experimental accuracy using a standard viral plaque assay as an example procedure. In particular, proper techniques to work safely in a BSL-4 environment when performing an experiment will be visually emphasized. These techniques include: setting up a Class II BSC for experiments, proper cleaning of the Class II BSC when finished working, waste management and safe disposal of waste generated inside a BSL-4 laboratory, and the removal of inactivated samples from inside a BSL-4 laboratory to the BSL-2 laboratory.

40 CFR 75.64 - Quarterly reports.

Code of Federal Regulations, 2013 CFR

2013-07-01

... placed in long-term cold storage (as defined in § 72.2 of this chapter), quarterly reports are not... the unit). For units placed into long-term cold storage during a reporting quarter, the exemption from... long-term cold storage. For any provisionally-certified monitoring system, § 75.20(a)(3) shall apply...

40 CFR 75.64 - Quarterly reports.

Code of Federal Regulations, 2012 CFR

2012-07-01

... placed in long-term cold storage (as defined in § 72.2 of this chapter), quarterly reports are not... the unit). For units placed into long-term cold storage during a reporting quarter, the exemption from... long-term cold storage. For any provisionally-certified monitoring system, § 75.20(a)(3) shall apply...

40 CFR 75.64 - Quarterly reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... placed in long-term cold storage (as defined in § 72.2 of this chapter), quarterly reports are not... the unit). For units placed into long-term cold storage during a reporting quarter, the exemption from... long-term cold storage. For any provisionally-certified monitoring system, § 75.20(a)(3) shall apply...

40 CFR 75.64 - Quarterly reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... placed in long-term cold storage (as defined in § 72.2 of this chapter), quarterly reports are not... the unit). For units placed into long-term cold storage during a reporting quarter, the exemption from... long-term cold storage. For any provisionally-certified monitoring system, § 75.20(a)(3) shall apply...

Tested Studies for Laboratory Teaching. Proceedings of the Workshop/Conference of the Association for Biology Laboratory Education (ABLE) (12th, Springfield, Missouri, June 4-8, 1990). Volume 12.

ERIC Educational Resources Information Center

Goldman, Corey A., Ed.

The focus of the Association for Biology Laboratory Education (ABLE) is to improve the undergraduate biology laboratory experience by promoting the development and dissemination of interesting, innovative, and reliable laboratory exercises. This proceedings volume includes 13 papers: "Non-Radioactive DNA Hybridization Experiments for the…

Primary Murine CD4+ T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation

PubMed Central

Janardhan, Sujit V.; Marks, Reinhard; Gajewski, Thomas F.

2014-01-01

Constitutive Ras signaling has been shown to augment IL-2 production, reverse anergy, and functionally replace many aspects of CD28 co-stimulation in CD4+ T cells. These data raise the possibility that introduction of active Ras into primary T cells might result in improved functionality in pathologic situations of T cell dysfunction, such as cancer or chronic viral infection. To test the biologic effects of active Ras in primary T cells, CD4+ T cells from Coxsackie-Adenovirus Receptor Transgenic mice were transduced with an adenovirus encoding active Ras. As expected, active Ras augmented IL-2 production in naive CD4+ T cells. However, when cells were cultured for 4 days under conditions to promote effector cell differentiation, active Ras inhibited the ability of CD4+ T cells to acquire a Th1 or Th2 effector cytokine profile. This differentiation defect was not due to deficient STAT4 or STAT6 activation by IL-12 or IL-4, respectively, nor was it associated with deficient induction of T-bet and GATA-3 expression. Impaired effector cytokine production in active Ras-transduced cells was associated with deficient demethylation of the IL-4 gene locus. Our results indicate that, despite augmenting acute activation of naïve T cells, constitutive Ras signaling inhibits the ability of CD4+ T cells to properly differentiate into Th1/Th2 effector cytokine-producing cells, in part by interfering with epigenetic modification of effector gene loci. Alternative strategies to potentiate Ras pathway signaling in T cells in a more regulated fashion should be considered as a therapeutic approach to improve immune responses in vivo. PMID:25397617

6th International Conference on Biophysics & Synchrotron Radiation. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moffat, Keith

1999-08-03

The 6th International Conference on Biophysics and Synchrotron Rdiation was held at the Advanced Photon Source, Argonne National Laboratory, from August 4-8, 1998, with pre-conference activities on August 3. Over 300 attendees and 65 presenters participated in the conference that was collaboratively hosted by the University of Chicago, Center for Advanced Radiation Sources and the Advanced Photon Source.

75 FR 20373 - Quarterly IRS Interest Rates Used in Calculating Interest on Overdue Accounts and Refunds on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... DEPARTMENT OF HOMELAND SECURITY Customs and Border Protection Quarterly IRS Interest Rates Used in... quarterly Internal Revenue Service interest rates used to calculate interest on overdue accounts..., the interest rates for overpayments will be 3 percent for corporations and 4 percent for non...

Proceedings of the 4th fire in eastern oak forests conference

Treesearch

Daniel C. Dey; Michael C. Stambaugh; Stacy L. Clark; Callie J., eds. Schweitzer

2012-01-01

Contains 14 full-length papers and 40 abstracts of posters that were presented at the 4th Fire in Eastern Oak Forests conference, held in Springfield, MO, May 17-19, 2011. The conference was attended by over 250 people from 65 different organizations and entities, representing 22 states and 1 Canadian province.

FOREWORD: 4th International Colloquium on Atomic Spectra and Oscillator Strengths for Astrophysical and Laboratory Plasmas

NASA Astrophysics Data System (ADS)

Leckrone, David S.; Sugar, Jack

1993-01-01

In 1983 the Atomic Spectroscopy Group at the University of Lund organized a conference at Lund the purpose of which was to establish a dialogue between scientists whose research made use of basic atomic data, and scientists whose research produced such data. The data in question include complete descriptions of atomic and ionic spectra, accurate transition wavelengths and relative intensities, energy levels, lifetimes, oscillator strengths, line shapes, and nuclear effects (hyperfine structure and isotope shifts). The "consumers" in urgent need of new or improved atomic data included astrophysicsts, laboratory plasma physicists, and spectrochemists. The synergism between these specialists and the theoretical and experimental atomic physicists resulted in a highly successful meeting, attended by approximately 70 people. The rapid advances foreseen at that time in all of these areas of observational, experimental and theoretical science stimulated planning for a second conference on this subject in 1986 at the University of Toledo, and subsequently a third meeting was held at the Royal Netherlands Academy of Arts and Sciences in Amsterdam in 1989. Again attendance at the latter two meetings totaled approximately 70 researchers. The participants in Amsterdam agreed to re-convene at the National Institute of Standards and Technology (NIST) in Gaithersburg, Maryland, in 1992, maintaining the frequency of these conferences at one every three years. The present Topical Issue of Physica Scripta consists of 31 invited reviews given at the Gaithersburg meeting. Extended abstracts of 63 poster papers from the meeting are being published in NIST Special Publication SP850. Approximately 170 scientists attended the Gaithersburg conference, representing a substantial growth in the size of meetings in this series. One session of the conference was devoted to an informal workshop, at which any participant could give a brief oral statement about his or her most immediate data need

78 FR 23866 - Safety Zone; Crescent City 4th of July Fireworks; Crescent City Harbor, Crescent City, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-23

...-AA00 Safety Zone; Crescent City 4th of July Fireworks; Crescent City Harbor, Crescent City, CA AGENCY... a temporary safety zone in the navigable waters near Crescent City, CA in support of the Crescent City 4th of July Fireworks on July 4, 2013. This safety zone is necessary to ensure the safety of...

Crime rates and sedentary behavior among 4th grade Texas school children.

PubMed

Brown, H Shelton; Pérez, Adriana; Mirchandani, Gita G; Hoelscher, Deanna M; Kelder, Steven H

2008-05-14

Although per capita crime has generally fallen over the period which coincides with the obesity epidemic, it has not fallen uniformly across communities. It also has not fallen enough to allay fears on the part of parents. Over the past 30 years, technological changes have made the indoor alternatives to playing outside, where children are more vulnerable to criminal activity, more enjoyable (cable TV, video games, and the internet) and comfortable (the spread of air conditioning to low income neighborhoods). We determined whether indoor sedentary behavior patterns are associated with community crime statistics. 4th graders in the U.S. are typically 9 or 10 years old. We used data from the 2004-2005 Texas School Physical Activity and Nutrition (SPAN) survey linked with U.S. Department of Justice, Office of Justice Programs, Bureau of Justice Statistics data for the years 2000 through 2005 and Texas State data on sexual offenders. The probability-based sample included a total of 7,907 children in grade four. Multistage probability sampling weights were used. The dependent variables included were hours of TV watching, video game playing, computer use and total indoor sedentary behavior after school. Incremental Relative Rates were computed for community crime rates including robberies, all violent crimes, murders, assaults, property crimes, rapes, burglaries, larcenies and motor vehicle thefts as well as for sexual offenders living in the neighborhood. The neighborhood refers to the areas where the students at each school live. In the case of sexual offenders, sexual offenders per capita are estimated using the per capita rate in the zip code of the school attended; all other crime statistics are estimated by the crimes per capita in the police department jurisdiction covering the school attended. After controlling for sex, age, and African-American and Hispanic, cross-sectional associations were determined using multivariate Poisson regression. 4th grade boys were

Crime rates and sedentary behavior among 4th grade Texas school children

PubMed Central

Brown, H Shelton; Pérez, Adriana; Mirchandani, Gita G; Hoelscher, Deanna M; Kelder, Steven H

2008-01-01

Introduction Although per capita crime has generally fallen over the period which coincides with the obesity epidemic, it has not fallen uniformly across communities. It also has not fallen enough to allay fears on the part of parents. Over the past 30 years, technological changes have made the indoor alternatives to playing outside, where children are more vulnerable to criminal activity, more enjoyable (cable TV, video games, and the internet) and comfortable (the spread of air conditioning to low income neighborhoods). We determined whether indoor sedentary behavior patterns are associated with community crime statistics. 4th graders in the U.S. are typically 9 or 10 years old. Methods We used data from the 2004–2005 Texas School Physical Activity and Nutrition (SPAN) survey linked with U.S. Department of Justice, Office of Justice Programs, Bureau of Justice Statistics data for the years 2000 through 2005 and Texas State data on sexual offenders. The probability-based sample included a total of 7,907 children in grade four. Multistage probability sampling weights were used. The dependent variables included were hours of TV watching, video game playing, computer use and total indoor sedentary behavior after school. Incremental Relative Rates were computed for community crime rates including robberies, all violent crimes, murders, assaults, property crimes, rapes, burglaries, larcenies and motor vehicle thefts as well as for sexual offenders living in the neighborhood. The neighborhood refers to the areas where the students at each school live. In the case of sexual offenders, sexual offenders per capita are estimated using the per capita rate in the zip code of the school attended; all other crime statistics are estimated by the crimes per capita in the police department jurisdiction covering the school attended. After controlling for sex, age, and African-American and Hispanic, cross-sectional associations were determined using multivariate Poisson regression

Computational mechanics research and support for aerodynamics and hydraulics at TFHRC year 1 quarter 4 progress report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lottes, S.A.; Kulak, R.F.; Bojanowski, C.

2011-12-09

The computational fluid dynamics (CFD) and computational structural mechanics (CSM) focus areas at Argonne's Transportation Research and Analysis Computing Center (TRACC) initiated a project to support and compliment the experimental programs at the Turner-Fairbank Highway Research Center (TFHRC) with high performance computing based analysis capabilities in August 2010. The project was established with a new interagency agreement between the Department of Energy and the Department of Transportation to provide collaborative research, development, and benchmarking of advanced three-dimensional computational mechanics analysis methods to the aerodynamics and hydraulics laboratories at TFHRC for a period of five years, beginning in October 2010. Themore » analysis methods employ well-benchmarked and supported commercial computational mechanics software. Computational mechanics encompasses the areas of Computational Fluid Dynamics (CFD), Computational Wind Engineering (CWE), Computational Structural Mechanics (CSM), and Computational Multiphysics Mechanics (CMM) applied in Fluid-Structure Interaction (FSI) problems. The major areas of focus of the project are wind and water effects on bridges - superstructure, deck, cables, and substructure (including soil), primarily during storms and flood events - and the risks that these loads pose to structural failure. For flood events at bridges, another major focus of the work is assessment of the risk to bridges caused by scour of stream and riverbed material away from the foundations of a bridge. Other areas of current research include modeling of flow through culverts to assess them for fish passage, modeling of the salt spray transport into bridge girders to address suitability of using weathering steel in bridges, CFD analysis of the operation of the wind tunnel in the TFCHR wind engineering laboratory, vehicle stability under high wind loading, and the use of electromagnetic shock absorbers to improve vehicle stability

United States housing, third quarter 2013

Treesearch

Delton Alderman

2017-01-01

The U.S. housing construction market’s third quarter was subdued, as all sectors moderated or declined. Once again, consensus expectations were for aggregate housing market gains, and these expectations were not realized. Overall starts, housing under construction, and completion data indicated quarterly improvement. Viewed from a recent his¬torical context, all...

Results for the Fourth Quarter Calendar Year 2015 Tank 50H Salt Solution Sample

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, C.

In this memorandum, the chemical and radionuclide contaminant results from the Fourth Quarter Calendar Year 2015 (CY15) sample of Tank 50H salt solution are presented in tabulated form. The Fourth Quarter CY15 Tank 50H samples were obtained on October 29, 2015 and received at Savannah River National Laboratory (SRNL) on October 30, 2015. The information from this characterization will be used by Defense Waste Processing Facility (DWPF) & Saltstone Facility Engineering for the transfer of aqueous waste from Tank 50H to the Salt Feed Tank in the Saltstone Production Facility, where the waste will be treated and disposed of inmore » the Saltstone Disposal Facility. This memorandum compares results, where applicable, to Saltstone Waste Acceptance Criteria (WAC) limits and targets. Data pertaining to the regulatory limits for Resource Conservation and Recovery Act (RCRA) metals will be documented at a later time per the Task Technical and Quality Assurance Plan (TTQAP) for the Tank 50H saltstone task. The chemical and radionuclide contaminant results from the characterization of the Fourth Quarter Calendar Year 2015 (CY15) sampling of Tank 50H were requested by SRR personnel and details of the testing are presented in the SRNL Task Technical and Quality Assurance Plan.« less

Asteroid Lightcurve Analysis at Via Capote Observatory: 4th Quarter 2009

NASA Astrophysics Data System (ADS)

Brinsfield, James W.

2010-04-01

Nine asteroids were observed and their lightcurves periods and amplitudes were measured at the Via Capote Observatory from 2009 September through December 2009: 449 Hamburga (18.263 ± 0.004 h; 0.09 mag), 527 Euryanthe (26.06 ± 0.01 h; 0.12 mag), 1023 Thomana (17.65 ± 0.01 h; 0.38 mag), 1345 Potomac (11.41 ± 0.01 h; 0.24 mag), 1398 Donnera (7.23 ± 0.01 h; 0.15 mag), 1564 Srbija (9.135 ± 0.001 h; 0.17 mag), 1994 Shane (8.220 ± 0.001 h; 0.26 mag), 2888 Hodgson (6.905 ± 0.001 h; 0.14 mag), and 15967 Clairearmstrong (5.90 ± 0.01 h; 0.33 mag).

4. Exterior view of Components Test Laboratory (T27), looking northeast. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Exterior view of Components Test Laboratory (T-27), looking northeast. The building wing on the left houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault, and that on the right houses Test Cell 10 (environmental). - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

Navistar eStar Vehicle Performance Evaluation – 4th Quarter 2013; Energy Efficiency & Renewable Energy (EERE), Vehicle Technologies Office (VTO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-01-01

The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Navistar will build and deploy all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

American Association of Women in Community and Junior Colleges Quarterly; Vol. XVI, Nos. 1-4.

ERIC Educational Resources Information Center

AAWCJC Quarterly, 1992

1992-01-01

The American Association of Women in Community and Junior Colleges (AAWCJC), an affiliated council of the American Association of Community and Junior Colleges (AACJC), produces the "Quarterly" to disseminate information pertinent to the AAWCJC membership and to provide a forum for the discussion of current issues and events. Each issue of the…

2. View to northeast showing quarters and outbuildings, L to ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. View to northeast showing quarters and outbuildings, L to R: Service Building (HABS No. VA-1287-D), Medical Officer's Quarters C (in background), Garage (HABS No. VA-1287-F), and Medical Officer's Quarters B - Portsmouth Naval Hospital, Medical Officer's Quarters C, West side Williamson Drive, 400 feet South of Rixey Drive, Portsmouth, Portsmouth, VA

77 FR 51705 - Rescission of Quarterly Financial Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... No. FMCSA-2012-0020] RIN-2126-AB48 Rescission of Quarterly Financial Reporting Requirements AGENCY...: FMCSA withdraws its June 27, 2012, direct final rule eliminating the quarterly financial reporting... future proposing the elimination of the quarterly financial reporting requirements for Form QFR and Form...

Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis

PubMed Central

Sallin, Michelle A.; Sakai, Shunsuke; Kauffman, Keith D.; Young, Howard A.; Zhu, Jinfang; Barber, Daniel L.

2017-01-01

SUMMARY Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1 polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL-12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of CD69+CD103+ tissue resident phenotype effectors in lung. In contrast, Th1 cell-derived IFNγ inhibits the accumulation of intravascular CX3CR1+KLRG1+ Th1 cells. Thus, although IL-12 and T-bet are essential host survival factors, they simultaneously oppose lung CD4 T cell responses at several levels, demonstrating the dual nature of Th1 polarization in tuberculosis. PMID:28355562

Sharpening the U-Th Chronometer: Progress and Outlook

NASA Astrophysics Data System (ADS)

McLean, N. M.; Condon, D. J.; Henderson, G. M.; Richards, D. A.; Noble, S.; Mason, A.

2013-12-01

Uranium is incorporated into a variety of natural materials when they form, including carbonates like speleothems and corals. The two most abundant naturally occurring uranium isotopes, 238U and 235U, decay to 206Pb and 207Pb over long timescales with half-lives of 4.5 and 0.7 billion years respectively, but transition through several intermediate daughter isotopes with shorter half-lives first. Fractionation between these daughter isotopes, including 234U, 230Th, and 231Pa, and their parent isotopes, followed by their time-dependent return to secular equilibrium over the course of up to ~800 kyr, forms the basis for U-series geochronology, and allows speleothems and corals to be precisely dated. These carbonates often additionally incorporate chemical and isotopic signatures (e.g., trace elements, δ18O and δ13C) from the environment in which they form, and thus are some of the best dated paleoclimate archives, offering clues about past and future conditions for life on Earth. Over the past decade, the analytical precision of U-series isotope measurements has improved dramatically, largely due to the steadily increasing sensitivity of multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). Analytical uncertainties in U-Th dates now approach or are better than 0.1% (2σ), for instance ×100 years for a speleothem or coral that is 130 kyr old (Cheng et al., 2013). However, the accuracy of U-series dates also depends on the accuracy of tracer calibrations, reference solutions and data reduction protocols, which has not kept pace in many laboratories. This means that dates measured in different labs, while impressively precise, may not be directly comparable. To address issues of inter-laboratory bias and improve the accuracy and inter-comparability of U-Th dates, we have instigated work in three related directions. First, we report on the mixing of three synthetic U-Th age solutions, created by combining high-purity mono-isotopic solutions to

Postanesthetic recumbency associated with hyperkalemic periodic paralysis in a quarter horse.

PubMed

Robertson, S A; Green, S L; Carter, S W; Bolon, B N; Brown, M P; Shields, R P

1992-10-15

Anesthesia and surgery in a Quarter Horse affected with hyperkalemic periodic paralysis resulted in euthanasia after 7 days of postoperative recumbency. Initial recovery was uneventful after extensive sinus surgery, but within 2 hours, the horse had severe muscle weakness. Plasma electrolyte concentrations were within the normal range during the period of recumbency. There was no clinical or laboratory evidence of severe muscle damage. Despite treatment with acetazolamide, isoproterenol, and intensive nursing, the horse was unable to stand for more than a few seconds and developed severe decubital ulcers. Ultrastructural examination revealed nemaline rods and swollen mitochondria in disrupted myofibers.

24th geotechnical laboratory testing short course

DOT National Transportation Integrated Search

2008-02-01

This is a 3-day workshop/short course to teach practicing professionals techniques and procedures for conducting high quality geotechnical laboratory tests. Transportation facility design and construction begins with an investigation of the type, ext...

Central Precocious Puberty: Adult Height in Girls Treated with Quarterly or Monthly Gonadotropin-Releasing Hormone Analog Triptorelin.

PubMed

Bertelloni, Silvano; Massart, Francesco; Einaudi, Silvia; Wasniewska, Malgorzata; Miccoli, Mario; Baroncelli, Giampiero I

2015-01-01

Treatment with quarterly gonadotropin-releasing hormone (GnRH) analogs may improve compliance and optimize outcome in girls with central precocious puberty (CPP), but long-term comparative data between the new and the monthly formulations are very scarce. A group of girls with idiopathic CPP (n = 13; age 7.9 ± 0.6 years) were treated from the beginning with quarterly triptorelin (11.25 mg/90 days) and followed up to the achievement of adult height (AH). A group of girls with idiopathic CPP (n = 12; age 8.0 ± 0.6 years) treated with monthly triptorelin (3.75 mg/28 days) served as controls. The AH (157.1 ± 4.9 cm) of girls treated with quarterly triptorelin was not significantly different from their mid-parental height (159.7 ± 3.8 cm) and significantly increased in comparison with predicted AH (average tables) at the beginning of GnRH analog therapy. The AH of girls treated with quarterly triptorelin was not significantly different in comparison with that of girls treated with the monthly formulation (158.1 ± 6.6 cm; mid-parental height 158.4 ± 5.0 cm). Treatment with quarterly triptorelin formulation permitted to achieve an AH adequate for mid-parental height in girls with CPP. Significant differences of AH between girls with CPP treated with quarterly or monthly formulations were not found. © 2015 S. Karger AG, Basel.

Can astronomy enhance UNESCO World Heritage recognition? The paradigm of 4th Dynasty Egyptian pyramids

NASA Astrophysics Data System (ADS)

Belmonte, Juan Antonio

2015-08-01

The pyramids of Egypt, notably those of the 4th Dinasty as Giza, have always be considered an unmistikable part of human world heritage as the only surviving wonders of the Ancient World. Their majesty, technical hability and innovative character have always beeen considered as representative of ancient Egyptian ingenuity. However, past and present fringe theories about the pyramids and astronomy have always polluted the role of our discipline in the design, construction and symbolism of these impressive monuments. This is indeed unfear. Fortunately, things have started to change in the last couple of decades and now astronomy is interpreted as a neccessary tool for the correct interpretation of the astral eschatology present in the 5th and 6th Dynasty Texts of the Pyramids. Although the pyramid complexes of the 4th Dynasty are mute, there is however recent research showing that a strong astral symbolism could be hidden in many aspects of the complex architecture and in the design of these exceptional monuments. This idea comes from several hints obtained not only from planning and construction, but also from epigraphy and the analysis of celestial and local landscapes. Chronology also plays a most relevant role on this. The pyramid complexes of the 4th Dynasty at Meidum, Dahshur, Giza and Abu Rowash -- all of which enjoy UNESCO World Heritage recognition -- willl be scrutinized. As a consequence, we will show how astronomy can certainly enhance the face value of these extraordinary monuments as a definitive proof of the ancient Egyptian quest for Ma'at, i.e. their perennial obsesion for Cosmic Order.

75 FR 37823 - Quarterly IRS Interest Rates Used in Calculating Interest on Overdue Accounts and Refunds on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Quarterly IRS Interest Rates... the public of the quarterly Internal Revenue Service interest rates used to calculate interest on... beginning July 1, 2010, the interest rates for overpayments will be 3 percent for corporations and 4 percent...

75 FR 419 - Quarterly IRS Interest Rates Used in Calculating Interest on Overdue Accounts and Refunds on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Quarterly IRS Interest Rates... the public of the quarterly Internal Revenue Service interest rates used to calculate interest on... beginning January 1, 2010, the interest rates for overpayments will be 3 percent for corporations and 4...

76 FR 41283 - Quarterly IRS Interest Rates Used in Calculating Interest on Overdue Accounts and Refunds on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Quarterly IRS Interest Rates... the public of the quarterly Internal Revenue Service interest rates used to calculate interest on... beginning July 1, 2011, the interest rates for overpayments will be 3 percent for corporations and 4 percent...

76 FR 20697 - Quarterly IRS Interest Rates Used in Calculating Interest on Overdue Accounts and Refunds on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Quarterly IRS Interest Rates... the public of the quarterly Internal Revenue Service interest rates used to calculate interest on... beginning April 1, 2011, the interest rates for overpayments will be 3 percent for corporations and 4...

[Development of cell content and shedding of Prototheca spp. in milk from infected udder quarters of cows].

PubMed

Tenhagen, B A; Hille, A; Schmidt, A; Heuwieser, W

2005-02-01

It was the objective of this study to analyse shedding patterns and somatic cell counts in cows and quarters infected with Prototheca spp. and to evaluate two approaches to identify infected animals by somatic cell count (SCC) or by bacteriological analysis of pooled milk samples. Five lactating dairy cows, chronically infected with Prototheca spp. in at least one quarter were studied over 11 weeks to 13 months. Quarter milk samples and a pooled milk sample from 4 quarters were collected aseptically from all quarters of the cows on a weekly basis. Culture results of quarter milk and pooled samples were compared using cross tabulation. SCC of quarter milk samples and of pooled samples were related to the probability of detection in the infected quarters and cows, respectively. Shedding of Prototheca spp. was continuous in 2 of 8 quarters. In the other quarters negative samples were obtained sporadically or over a longer period (1 quarter). Overall, Prototheca spp. were isolated from 83.6% of quarter milk samples and 77.0% of pooled milk samples of infected quarters and cows. Somatic cell counts were higher in those samples from infected quarters that contained the algae than in negative samples (p < 0.0001). The same applied for composite samples from infected cows. Positive samples had higher SCC than negative samples. However, Prototheca spp. were also isolated from quarter milk and pooled samples with physiological SCC (i.e. < 10(5)/ml). Infected quarters that were dried off did not develop acute mastitis. However, drying off had no effect on the infection, i.e. samples collected at calving or 8 weeks after dry off still contained Prototheca spp. Results indicate that pre-selection of cows to be sampled for Prototheca spp. by SCC and the use of composite samples are probably inadequate in attempts to eradicate the disease. However, due to intermittent shedding of the algae in some cows, single herd sampling using quarter milk samples probably also fails to detect

PREFACE: 4th International Conference on Mathematical Modeling in Physical Sciences (IC-MSquare2015)

NASA Astrophysics Data System (ADS)

Vlachos, Dimitrios; Vagenas, Elias C.

2015-09-01

The 4th International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place in Mykonos, Greece, from Friday 5th June to Monday 8th June 2015. The Conference was attended by more than 150 participants and hosted about 200 oral, poster, and virtual presentations. There were more than 600 pre-registered authors. The 4th IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics etc. The scientific program was rather intense as after the Keynote and Invited Talks in the morning, three parallel oral and one poster session were running every day. However, according to all attendees, the program was excellent with a high quality of talks creating an innovative and productive scientific environment for all attendees. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee.

First Quarter Hanford Seismic Report for Fiscal Year 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rohay, Alan C.; Sweeney, Mark D.; Hartshorn, Donald C.

2010-03-29

The Hanford Seismic Network and the Eastern Washington Regional Network consist of 44 individual sensor sites and 15 radio relay sites maintained by the Hanford Seismic Assessment Team. The Hanford Seismic Network recorded 81 local earthquakes during the first quarter of FY 2010. Sixty-five of these earthquakes were detected in the vicinity of Wooded Island, located about eight miles north of Richland just west of the Columbia River. The Wooded Island events recorded this quarter is a continuation of the swarm events observed during fiscal year 2009 and reported in previous quarterly and annual reports (Rohay et al; 2009a, 2009b,more » 2009c, and 2009d). Most of the events were considered minor (coda-length magnitude [Mc] less than 1.0) with only 1 event in the 2.0-3.0 range; the maximum magnitude event (2.5 Mc) occurred on December 22 at depth 2.1 km. The average depth of the Wooded Island events during the quarter was 1.4 km with a maximum depth estimated at 3.1 km. This placed the Wooded Island events within the Columbia River Basalt Group (CRBG). The low magnitude of the Wooded Island events has made them undetectable to all but local area residents. The Hanford SMA network was triggered several times by these events and the SMA recordings are discussed in section 6.0. During the last year some Hanford employees working within a few miles of the swarm area and individuals living directly across the Columbia River from the swarm center have reported feeling many of the larger magnitude events. Strong motion accelerometer (SMA) units installed directly above the swarm area at ground surface measured peak ground accelerations approaching 15% g, the largest values recorded at Hanford. This corresponds to strong shaking of the ground, consistent with what people in the local area have reported. However, the duration and magnitude of these swarm events should not result in any structural damage to facilities. The USGS performed a geophysical survey using satellite

United States housing, second quarter 2013

Treesearch

Delton Alderman

2017-01-01

The U.S. housing market’s quarter two results were disap¬pointing compared with the first quarter. Although overall expected gains did not materialize, certain sectors improved slightly. Housing under construction, completions, and new and existing home sales exhibited slight increases. Overall permit data declined, and the decrease in starts was due primarily to a...

United States housing, fourth quarter 2013

Treesearch

Delton Alderman

2017-01-01

In the beginning of 2013, the U.S. housing construction market indicated increases in all sectors; yet, by the fourth quarter’s end, only housing under construction improved. Moderation and declines are to be expected in the fourth quarter, as winter is setting in. Permits, starts, housing under construction, completions, and new and existing house sales all exceeded...

Comparison of turnaround time and total cost of HIV testing before and after implementation of the 2014 CDC/APHL Laboratory Testing Algorithm for diagnosis of HIV infection.

PubMed

Chen, Derrick J; Yao, Joseph D

2017-06-01

Updated recommendations for HIV diagnostic laboratory testing published by the Centers for Disease Control and Prevention and the Association of Public Health Laboratories incorporate 4th generation HIV immunoassays, which are capable of identifying HIV infection prior to seroconversion. The purpose of this study was to compare turnaround time and cost between 3rd and 4th generation HIV immunoassay-based testing algorithms for initially reactive results. The clinical microbiology laboratory database at Mayo Clinic, Rochester, MN was queried for 3rd generation (from November 2012 to May 2014) and 4th generation (from May 2014 to November 2015) HIV immunoassay results. All results from downstream supplemental testing were recorded. Turnaround time (defined as the time of initial sample receipt in the laboratory to the time the final supplemental test in the algorithm was resulted) and cost (based on 2016 Medicare reimbursement rates) were assessed. A total of 76,454 and 78,998 initial tests were performed during the study period using the 3rd generation and 4th generation HIV immunoassays, respectively. There were 516 (0.7%) and 581 (0.7%) total initially reactive results, respectively. Of these, 304 (58.9%) and 457 (78.7%) were positive by supplemental testing. There were 10 (0.01%) cases of acute HIV infection identified with the 4th generation algorithm. The most frequent tests performed to confirm an HIV-positive case using the 3rd generation algorithm, which were reactive initial immunoassay and positive HIV-1 Western blot, took a median time of 1.1 days to complete at a cost of $45.00. In contrast, the most frequent tests performed to confirm an HIV-positive case using the 4th generation algorithm, which included a reactive initial immunoassay and positive HIV-1/-2 antibody differentiation immunoassay for HIV-1, took a median time of 0.4 days and cost $63.25. Overall median turnaround time was 2.2 and 1.5 days, and overall median cost was $63.90 and $72.50 for

DB4US: A Decision Support System for Laboratory Information Management

PubMed Central

Hortas, Maria Luisa; Baena-García, Manuel; Lana-Linati, Jorge; González, Carlos; Redondo, Maximino; Morales-Bueno, Rafael

2012-01-01

Background Until recently, laboratory automation has focused primarily on improving hardware. Future advances are concentrated on intelligent software since laboratories performing clinical diagnostic testing require improved information systems to address their data processing needs. In this paper, we propose DB4US, an application that automates information related to laboratory quality indicators information. Currently, there is a lack of ready-to-use management quality measures. This application addresses this deficiency through the extraction, consolidation, statistical analysis, and visualization of data related to the use of demographics, reagents, and turn-around times. The design and implementation issues, as well as the technologies used for the implementation of this system, are discussed in this paper. Objective To develop a general methodology that integrates the computation of ready-to-use management quality measures and a dashboard to easily analyze the overall performance of a laboratory, as well as automatically detect anomalies or errors. The novelty of our approach lies in the application of integrated web-based dashboards as an information management system in hospital laboratories. Methods We propose a new methodology for laboratory information management based on the extraction, consolidation, statistical analysis, and visualization of data related to demographics, reagents, and turn-around times, offering a dashboard-like user web interface to the laboratory manager. The methodology comprises a unified data warehouse that stores and consolidates multidimensional data from different data sources. The methodology is illustrated through the implementation and validation of DB4US, a novel web application based on this methodology that constructs an interface to obtain ready-to-use indicators, and offers the possibility to drill down from high-level metrics to more detailed summaries. The offered indicators are calculated beforehand so that they

DB4US: A Decision Support System for Laboratory Information Management.

PubMed

Carmona-Cejudo, José M; Hortas, Maria Luisa; Baena-García, Manuel; Lana-Linati, Jorge; González, Carlos; Redondo, Maximino; Morales-Bueno, Rafael

2012-11-14

Until recently, laboratory automation has focused primarily on improving hardware. Future advances are concentrated on intelligent software since laboratories performing clinical diagnostic testing require improved information systems to address their data processing needs. In this paper, we propose DB4US, an application that automates information related to laboratory quality indicators information. Currently, there is a lack of ready-to-use management quality measures. This application addresses this deficiency through the extraction, consolidation, statistical analysis, and visualization of data related to the use of demographics, reagents, and turn-around times. The design and implementation issues, as well as the technologies used for the implementation of this system, are discussed in this paper. To develop a general methodology that integrates the computation of ready-to-use management quality measures and a dashboard to easily analyze the overall performance of a laboratory, as well as automatically detect anomalies or errors. The novelty of our approach lies in the application of integrated web-based dashboards as an information management system in hospital laboratories. We propose a new methodology for laboratory information management based on the extraction, consolidation, statistical analysis, and visualization of data related to demographics, reagents, and turn-around times, offering a dashboard-like user web interface to the laboratory manager. The methodology comprises a unified data warehouse that stores and consolidates multidimensional data from different data sources. The methodology is illustrated through the implementation and validation of DB4US, a novel web application based on this methodology that constructs an interface to obtain ready-to-use indicators, and offers the possibility to drill down from high-level metrics to more detailed summaries. The offered indicators are calculated beforehand so that they are ready to use when the user

1. CARRIAGE HOUSE (left) AND SLAVE QUARTERS, SOUTH FRONT. A ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. CARRIAGE HOUSE (left) AND SLAVE QUARTERS, SOUTH FRONT. A kitchen was included in the quarters. - Charles Fraser House, Carriage House & Slave Quarters, 55 King Street, Charleston, Charleston County, SC

Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients.

PubMed

Dutra, Walderez O; Correa-Oliveira, Rodrigo; Dunne, David; Cecchini, Luiza Fosenca; Fraga, Lúcia; Roberts, Morven; Soares-Silveira, Alda Maria; Webster, Michelle; Yssel, Hans; Gollob, Kenneth J

2002-07-06

Human resistance to re-infection with S. mansoni is correlated with high levels of anti-soluble adult worm antigens (SWAP) IgE. Although it has been shown that IL-4 and IL-5 are crucial in establishing IgE responses in vitro, the active in vivo production of these cytokines by T cells, and the degree of polarization of Th2 vs. Th0 in human schistosomiasis is not known. To address this question, we determined the frequency of IL-4 and IFN-gamma or IL-5 and IL-2 producing lymphocytes from schistosomiasis patients with high or low levels of IgE anti-SWAP. Our analysis showed that high and low IgE-producers responded equally to schistosomiasis antigens as determined by proliferation. Moreover, patients from both groups displayed similar percentages of circulating lymphocytes. However, high IgE-producers had an increased percentage of activated CD4+ T cells as compared to the low IgE-producers. Moreover, intracellular cytokine analysis, after short-term stimulation with anti-CD3/CD28 mAbs, showed that IgE high-producers display an increase in the percentage of T lymphocytes expressing IL-4 and IL-5 as compared to IgE low-responders. A coordinate control of the frequency of IL-4 and IL-5 producing lymphocytes in IgE high, but not IgE low-responders, was observed. High IgE phenotype human schistosomiasis patients exhibit a coordinate regulation of IL-4 and IL-5 producing cells and the lymphocyte derived IL-4 comes from true polarized Th2 like cells, in the absence of measurable Th0 cells as measured by co-production of IL-4 and IFN-gamma.

Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients

PubMed Central

Dutra, Walderez O; Correa-Oliveira, Rodrigo; Dunne, David; Cecchini, Luiza Fosenca; Fraga, Lúcia; Roberts, Morven; Soares-Silveira, Alda Maria; Webster, Michelle; Yssel, Hans; Gollob, Kenneth J

2002-01-01

Background Human resistance to re-infection with S. mansoni is correlated with high levels of anti-soluble adult worm antigens (SWAP) IgE. Although it has been shown that IL-4 and IL-5 are crucial in establishing IgE responses in vitro, the active in vivo production of these cytokines by T cells, and the degree of polarization of Th2 vs. Th0 in human schistosomiasis is not known. To address this question, we determined the frequency of IL-4 and IFN-γ or IL-5 and IL-2 producing lymphocytes from schistosomiasis patients with high or low levels of IgE anti-SWAP. Results Our analysis showed that high and low IgE-producers responded equally to schistosomiasis antigens as determined by proliferation. Moreover, patients from both groups displayed similar percentages of circulating lymphocytes. However, high IgE-producers had an increased percentage of activated CD4+ T cells as compared to the low IgE-producers. Moreover, intracellular cytokine analysis, after short-term stimulation with anti-CD3/CD28 mAbs, showed that IgE high-producers display an increase in the percentage of T lymphocytes expressing IL-4 and IL-5 as compared to IgE low-responders. A coordinate control of the frequency of IL-4 and IL-5 producing lymphocytes in IgE high, but not IgE low-responders, was observed. Conclusions High IgE phenotype human schistosomiasis patients exhibit a coordinate regulation of IL-4 and IL-5 producing cells and the lymphocyte derived IL-4 comes from true polarized Th2 like cells, in the absence of measurable Th0 cells as measured by co-production of IL-4 and IFN-γ. PMID:12100735

22. VIEW SHOWING CREW'S QUARTERS IN FORECASTLE, LOOKING FORWARD FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. VIEW SHOWING CREW'S QUARTERS IN FORECASTLE, LOOKING FORWARD FROM DOOR IN PORT SIDE OF BULKHEAD; BUNK FRAME, (LEFT IN VIEW), REMAINS OF SMALL CAST IRON STOVE NEAR DECK STANCHION (CENTER OF VIEW) - Bugeye "Louise Travers", Intersection of Routes 2 & 4, Solomons, Calvert County, MD

Electric Power Quarterly, October-December 1985. [Glossary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-05-05

The Electric Power Quarterly (EPQ) provides information on electric utilities at the plant level. The information concerns the following: cost, quantity, and quality of fossil fuel receipts; net generation; fuel consumption; and fuel stocks. The EPQ contains monthly data and quarterly totals for the reporting quarter. Data collected on Form EIA-759 regarding electric utilities' net generation, fuel consumption, and fuel stocks are presented on a plant-by-plant basis. In addition, quantity, cost, and quality of fossil fuel receipts collected on the Federal Energy Regulatory Commission (FERC) Form 423 are presented on a plant-by-plant basis.

Oral immunization with F4 fimbriae and CpG formulated with carboxymethyl starch enhances F4-specific mucosal immune response and modulates Th1 and Th2 cytokines in weaned pigs.

PubMed

Delisle, Benjamin; Calinescu, Carmen; Mateescu, Mircea Alexandru; Fairbrother, John Morris; Nadeau, Éric

2012-01-01

F4 fimbriae are a potential candidate for an oral subunit vaccine for prevention of post-weaning diarrhea in swine due to infection with F4-positive enterotoxigenic Escherichia coli. However, large quantities of F4 fimbriae are required to induce a specific antibody response. The aim of the present study was to evaluate the effect of supplementation of F4 fimbriae with Cytosine-phosphate-Guanosine-oligodeoxynucleotide (CpG-A D19) or with complete cholera toxin (CT) as adjuvants on the F4-specific antibody response and cytokine production in weaned pigs following oral administration of F4 fimbrial antigen formulated with Carboxymethyl Starch (CMS). Oral dosage forms of F4 fimbriae alone or supplemented with CpG-A D19 or with CT were formulated with CMS as monolithic tablets, obtained by direct compression, and administered to weaned pigs. Blood and faecal samples were collected to determine the systemic and mucosal immune status of animals at various times until necropsy. During necropsy, contents of the jejunum and ileum were collected for determination of mucosal F4 specific antibodies. Segments of jejunum and ileum were also used to measure mRNA cytokine production. The presence of CpG in the formulation of the fimbriae significantly increased F4-specific immunoglobulin (Ig) IgM and IgG levels in intestinal secretions, and enhanced Th1 (Interferon-gamma / IFN-γ, Tumour Necrosis Factor-alpha / TNF-α, Interleukin-12p40 / IL-12p40, IL-1β) and Th2 (IL-4, IL-6) cytokine production in intestinal tissues. Supplementation with CT did not result in induction of F4-specific antibodies in secretions, although a significant Th1 response (IFN-α, IFN-γ, IL-18) was detected in tissues. Neither F4-specific systemic antibodies, nor intestinally secreted IgA were detected throughout the immunization trial for all groups. CpG-A D19 appeared to be a promising adjuvant for an oral F4 subunit vaccine formulated with CMS excipient as monolithic tablets. This matrix afforded gastro

Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T cell subsets in multiple sclerosis patients.

PubMed

Sacramento, Priscila M; Monteiro, Clarice; Dias, Aleida S O; Kasahara, Taissa M; Ferreira, Thaís B; Hygino, Joana; Wing, Ana Cristina; Andrade, Regis M; Rueda, Fernanda; Sales, Marisa C; Vasconcelos, Claudia Cristina; Bento, Cleonice A M

2018-05-02

Excessive levels of pro-inflammatory cytokines in the central nervous system (CNS) are associated with reduced serotonin (5-HT) synthesis, a neurotransmitter with diverse immune effects. In this study, we evaluated the ability of exogenous 5-HT to modulate the T-cell behavior of patients with multiple sclerosis (MS), a demyelinating autoimmune disease mediated by Th1 and Th17 cytokines. Here, 5-HT attenuated, in vitro, T-cell proliferation and Th1 and Th17 cytokines production in cell cultures from MS patients. Additionally, 5-HT reduced IFN-γ and IL-17 release by CD8 + T-cells. By contrast, 5-HT increased IL-10 production by CD4 + T-cells from MS patients. A more accurate analysis of these IL-10-secreting CD4 + T-cells revealed that 5-HT favors the expansion of FoxP3 + CD39 + regulatory T cells (Tregs) and type 1 regulatory T cells. Notably, this neurotransmitter also elevated the frequency of Treg17 cells, a novel regulatory T-cell subset. The effect of 5-HT in up-regulating CD39 + Treg and Treg17 cells was inversely correlated with the number of active brain lesions. Finally, in addition to directly reducing cytokine production by purified Th1 and Th17 cells, 5-HT enhanced in vitro Treg function. In summary, our data suggest that serotonin may play a protective role in the pathogenesis of MS. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Report of the 4th Workshop for Technology Transfer for Intelligent Compaction Consortium.

DOT National Transportation Integrated Search

2016-03-01

On October 2728, 2015, the Kentucky Transportation Cabinet (KYTC) hosted the 4th workshop for : the Technology Transfer for Intelligent Compaction Consortium (TTICC), a Transportation Pooled Fund : (TPF5(233)) initiative designed to identify, s...

Pinus densiflora bark extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by regulating Th1/Th2 balance and skin barrier function.

PubMed

Lee, Jun Woo; Wu, Qianwen; Jang, Young Pyo; Choung, Se Young

2018-06-01

Korean red pine (Pinus densiflora) bark has been traditionally used in Korea and other parts of East Asia to relieve inflammatory diseases. Although many studies using P. densiflora bark have been reported, its effect on atopic dermatitis (AD) has not been elucidated. Thus, we investigated whether the P. densiflora bark extract (PBE) has potential to attenuate AD symptoms and elucidated the molecular mechanism. Oral administration of PBE to mice with 2,4-dinitrochlorobenzene (DNCB)-induced AD lessened dermatitis scores and scratching behavior and significantly reduced measures of epidermal thickness, infiltration of mast cells and eosinophils, levels of immunoglobulin E (IgE), and IgG 1 /IgG 2a ratio in serum. PBE not only inhibited IL-4, IL-5, and IL-13 but also increased IFN-γ in splenic production. Furthermore, PBE significantly suppressed mRNA expression of thymic stromal lymphopoietin and further downregulated the mRNA expression of Th2 and Th17 cytokines such as IL-4, IL-13, IL-17, IL-31, and TNF-α. In addition, the protein expressions of filaggrin, involucrin, and loricrin in lesional skin were recovered by PBE. These results suggest that PBE attenuates DNCB-induced AD via regulating Th1/Th2 balance and skin barrier function. Copyright © 2018 John Wiley & Sons, Ltd.

Chemical and structural evolution in the Th-SeO3(2-)/SeO4(2-) system: from simple selenites to cluster-based selenate compounds.

PubMed

Xiao, Bin; Langer, Eike; Dellen, Jakob; Schlenz, Hartmut; Bosbach, Dirk; Suleimanov, Evgeny V; Alekseev, Evgeny V

2015-03-16

While extensive success has been gained in the structural chemistry of the U-Se system, the synthesis and characterization of Th-based Se structures are widely unexplored. Here, four new Th-Se compounds, α-Th(SeO3)2, β-Th(SeO3)2, Th(Se2O5)2, and Th3O2(OH)2(SeO4)3, have been obtained from mild hydrothermal or low-temperature (180-220 °C) flux conditions and were subsequently structurally and spectroscopically characterized. The crystal structures of α-Th(SeO3)2 and β-Th(SeO3)2 are based on ThO8 and SeO3 polyhedra, respectively, featuring a three-dimensional (3D) network with selenite anions filling in the Th channels along the a axis. Th(Se2O5)2 is a 3D framework composed of isolated ThO8 polyhedra interconnected by [Se2O5](2-) dimers. Th3O2(OH)2(SeO4)3 is also a 3D framework constructed by octahedral hexathorium clusters [Th6(μ3-O)4(μ3-OH)4](12+), which are interlinked by selenate groups SeO4(2-). The positions of the vibrational modes associated with both Se(IV)O3(2-) and Se(VI)O4(2-) units, respectively, were determined for four compounds, and the Raman spectra of α- and β-Th(SeO3)2 are compared and discussed in detail.

17 CFR 274.130 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 274.130 Section 274.130 Commodity... INVESTMENT COMPANY ACT OF 1940 Forms for Reports § 274.130 Form N-Q, quarterly schedule of portfolio holdings...

17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered...

Some boundary-value problems for anisotropic quarter plane

NASA Astrophysics Data System (ADS)

Arkhypenko, K. M.; Kryvyi, O. F.

2018-04-01

To solve the mixed boundary-value problems of the anisotropic elasticity for the anisotropic quarter plane, a method based on the use of the space of generalized functions {\\Im }{\\prime }({\\text{R}}+2) with slow growth properties was developed. The two-dimensional integral Fourier transform was used to construct the system of fundamental solutions for the anisotropic quarter plane in this space and a system of eight boundary integral relations was obtained, which allows one to reduce the mixed boundary-value problems for the anisotropic quarter plane directly to systems of singular integral equations with fixed singularities. The exact solutions of these systems were found by using the integral Mellin transform. The asymptotic behavior of solutions was investigated at the vertex of the quarter plane.

Physician satisfaction with clinical laboratory services: a College of American Pathologists Q-probes study of 138 institutions.

PubMed

Jones, Bruce A; Bekeris, Leonas G; Nakhleh, Raouf E; Walsh, Molly K; Valenstein, Paul N

2009-01-01

Monitoring customer satisfaction is a valuable component of a laboratory quality improvement program. To survey the level of physician satisfaction with hospital clinical laboratory services. Participating institutions provided demographic and practice information and survey results of physician satisfaction with defined aspects of clinical laboratory services, rated on a scale of 1 (poor) to 5 (excellent). One hundred thirty-eight institutions participated in this study and submitted a total of 4329 physician surveys. The overall satisfaction score for all institutions ranged from 2.9 to 5.0. The median overall score for all participants was 4.1 (10th percentile, 3.6; 90th percentile, 4.5). Physicians were most satisfied with the quality/reliability of results and staff courtesy, with median values of excellent or good ratings of 89.9%. Of the 5 service categories that received the lowest percentage values of excellent/good ratings (combined scores of 4 and 5), 4 were related to turnaround time for inpatient stat, outpatient stat, routine, and esoteric tests. Surveys from half of the participating laboratories reported that 96% to 100% of physicians would recommend the laboratory to other physicians. The category most frequently selected as the most important category of laboratory services was quality/reliability of results (31.7%). There continues to be a high level of physician satisfaction and loyalty with clinical laboratory services. Test turnaround times are persistent categories of dissatisfaction and present opportunities for improvement.

Summary of the 4th Nordic Symposium on Digital Pathology.

PubMed

Lundström, Claes; Waltersson, Marie; Persson, Anders; Treanor, Darren

2017-01-01

The Nordic symposium on digital pathology (NDP) was created to promote knowledge exchange across stakeholders in health care, industry, and academia. In 2016, the 4 th NDP installment took place in Linköping, Sweden, promoting development and collaboration in digital pathology for the benefit of routine care advances. This article summarizes the symposium, gathering 170 attendees from 13 countries. This summary also contains results from a survey on integrated diagnostics aspects, in particular radiology-pathology collaboration.