Sample records for laboratory analyses documentation

  1. [The maintenance of automatic analysers and associated documentation].

    PubMed

    Adjidé, V; Fournier, P; Vassault, A

    2010-12-01

    The maintenance of automatic analysers and associated documentation taking part in the requirements of the ISO 15189 Standard and the French regulation as well have to be defined in the laboratory policy. The management of the periodic maintenance and documentation shall be implemented and fulfilled. The organisation of corrective maintenance has to be managed to avoid interruption of the task of the laboratory. The different recommendations concern the identification of materials including automatic analysers, the environmental conditions to take into account, the documentation provided by the manufacturer and documents prepared by the laboratory including procedures for maintenance.

  2. Auditing of chromatographic data.

    PubMed

    Mabie, J T

    1998-01-01

    During a data audit, it is important to ensure that there is clear documentation and an audit trail. The Quality Assurance Unit should review all areas, including the laboratory, during the conduct of the sample analyses. The analytical methodology that is developed should be documented prior to sample analyses. This is an important document for the auditor, as it is the instrumental piece used by the laboratory personnel to maintain integrity throughout the process. It is expected that this document will give insight into the sample analysis, run controls, run sequencing, instrument parameters, and acceptance criteria for the samples. The sample analysis and all supporting documentation should be audited in conjunction with this written analytical method and any supporting Standard Operating Procedures to ensure the quality and integrity of the data.

  3. Review and comparison of quality standards, guidelines and regulations for laboratories.

    PubMed

    Datema, Tjeerd A M; Oskam, Linda; Klatser, Paul R

    2012-01-01

    The variety and number of laboratory quality standards, guidelines and regulations (hereafter: quality documents) makes it difficult to choose the most suitable one for establishing and maintaining a laboratory quality management system. There is a need to compare the characteristics, suitability and applicability of quality documents in view of the increasing efforts to introduce quality management in laboratories, especially in clinical diagnostic laboratories in low income and middle income countries. This may provide valuable insights for policy makers developing national laboratory policies, and for laboratory managers and quality officers in choosing the most appropriate quality document for upgrading their laboratories. We reviewed the history of quality document development and then selected a subset based on their current use. We analysed these documents following a framework for comparison of quality documents that was adapted from the Clinical Laboratory Standards Institute guideline GP26 Quality management system model for clinical laboratory services . Differences were identified between national and international, and non-clinical and clinical quality documents. The most salient findings were the absence of provisions on occurrence management and customer service in almost all non-clinical quality documents, a low number of safety requirements aimed at protecting laboratory personnel in international quality documents and no requirements regarding ethical behaviour in almost all quality documents. Each laboratory needs to investigate whether national regulatory standards are present. These are preferred as they most closely suit the needs of laboratories in the country. A laboratory should always use both a standard and a guideline: a standard sums up the requirements to a quality management system, a guideline describes how quality management can be integrated in the laboratory processes.

  4. QUALITY CONTROLS FOR PCR

    EPA Science Inventory

    The purpose of this presentation is to present an overview of the quality control (QC) sections of a draft EPA document entitled, "Quality Assurance/Quality Control Guidance for Laboratories Performing PCR Analyses on Environmental Samples." This document has been prepared by th...

  5. Emergency Response Capability Baseline Needs Assessment Compliance Assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharry, John A.

    2013-09-16

    This document is the second of a two-part analysis of Emergency Response Capabilities of Lawrence Livermore National Laboratory. The first part, 2013 Baseline Needs Assessment Requirements Document established the minimum performance criteria necessary to meet mandatory requirements. This second part analyses the performance of Lawrence Livermore Laboratory Emergency Management Department to the contents of the Requirements Document. The document was prepared based on an extensive review of information contained in the 2009 BNA, the 2012 BNA document, a review of Emergency Planning Hazards Assessments, a review of building construction, occupancy, fire protection features, dispatch records, LLNL alarm system records, firemore » department training records, and fire department policies and procedures.« less

  6. Fatigue crack growth behavior of railroad tank car steel TC-128B subjected to various environments. Volume 2 : appendices

    DOT National Transportation Integrated Search

    2006-12-01

    This is Volume II-Appendices of Fatigue Crack Growth Behavior of Railroad Tank Car Steel TC-128B Subjected to Various Environments. This document contains miscellaneous supporting documentation, fatigue crack growth laboratory data, and analyses.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wood, Craig; Halpern, Jonathan; Wrons, Ralph

    This Supplemental Information Source Document for Waste Management was prepared in support of future analyses including those that may be performed as part of the Sandia National Laboratories, New Mexico (SNL/NM) Site-Wide Environmental Impact Statement. This document presents information about waste management practices at SNL/NM, including definitions, inventory data, and an overview of current activities.

  8. Inorganic Analyses in Water Quality Control Programs. Training Manual.

    ERIC Educational Resources Information Center

    Office of Water Program Operations (EPA), Cincinnati, OH. National Training and Operational Technology Center.

    This document is a lecture/laboratory manual dealing with the analysis of selected inorganic pollutants. The manual is an instructional aid for classroom presentations to those with little or no experience in the field, but having one year (or equivalent) of college level inorganic chemistry and having basic laboratory skills. Topics include:…

  9. Organic Analyses in Water Quality Control Programs. Training Manual.

    ERIC Educational Resources Information Center

    Office of Water Program Operations (EPA), Cincinnati, OH. National Training and Operational Technology Center.

    This document is a lecture/laboratory manual dealing with the analysis of selected organic pollutants. It is intended for use by those having little or no experience in the field, but having one year (or equivalent) of college organic chemistry, and having basic laboratory skills (volumetric glassware, titration, analytical and trip balances).…

  10. Emergency Response Capability Baseline Needs Assessment - Compliance Assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharry, John A.

    This document was prepared by John A. Sharry, LLNL Fire Marshal and Division Leader for Fire Protection and was reviewed by LLNL Emergency Management Department Head, James Colson. This document is the second of a two-part analysis on Emergency Response Capabilities of Lawrence Livermore National Laboratory. The first part, 2016 Baseline Needs Assessment Requirements Document established the minimum performance criteria necessary to meet mandatory requirements. This second part analyses the performance of Lawrence Livermore Laboratory Emergency Management Department to the contents of the Requirements Document. The document was prepared based on an extensive review of information contained in the 2016more » BNA, a review of Emergency Planning Hazards Assessments, a review of building construction, occupancy, fire protection features, dispatch records, LLNL alarm system records, fire department training records, and fire department policies and procedures. The 2013 BNA was approved by NNSA’s Livermore Field Office on January 22, 2014.« less

  11. Changing patterns of daily precipitation totals at the Coweeta Hydrologic Laboratory, North Carolina, USA

    Treesearch

    T. P. Burt; C. Ford Miniat; S. H. Laseter; W. T. Swank

    2017-01-01

    A pattern of increasing frequency and intensity of heavy rainfall over land has been documented for several temperate regions and is associated with climate change. This study examines the changing patterns of daily precipitation at the Coweeta Hydrologic Laboratory, North Carolina, USA, since 1937 for four rain gauges across a range of elevations. We analyse...

  12. Sampling surface and subsurface particle-size distributions in wadable gravel-and cobble-bed streams for analyses in sediment transport, hydraulics, and streambed monitoring

    Treesearch

    Kristin Bunte; Steven R. Abt

    2001-01-01

    This document provides guidance for sampling surface and subsurface sediment from wadable gravel-and cobble-bed streams. After a short introduction to streams types and classifications in gravel-bed rivers, the document explains the field and laboratory measurement of particle sizes and the statistical analysis of particle-size distributions. Analysis of particle...

  13. National Aquatic Resource Surveys (NARS) Technical Support and Research

    EPA Science Inventory

    OW has overall responsibility for all operational aspects of the National Aquatic Resource Surveys (NARS) and funds all field operations, laboratory analyses, and information management. They are responsible for preparation of all documents, including QAPP, field operation manual...

  14. High-Explosives Applications Facility (HEAF)

    NASA Astrophysics Data System (ADS)

    Morse, J. L.; Weingart, R. C.

    1989-03-01

    This Safety Analysis Report (SAR) reviews the safety and environmental aspects of the High Explosives Applications Facility (HEAF). Topics covered include the site selected for the HEAF, safety design criteria, operations planned within the facility, and the safety and environmental analyses performed on this project to date. Provided in the Summary section is a review of hazards and the analyses, conclusions, and operating limits developed in this SAR. Appendices provide supporting documents relating to this SAR. This SAR is required by the LLNL Health and Safety Manual and DOE Order 5481.1B(2) to document the safety analysis efforts. The SAR was assembled by the Hazards Control Department, B-Division, and HEAF project personnel. This document was reviewed by B Division, the Chemistry Department, the Hazards Control Department, the Laboratory Associate Director for Administration and Operations, and the Associate Directors ultimately responsible for HEAF operations.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, G.L.

    This data package satisfies the requirement for a format IV, final report. It is a follow-up to the 45-day safety screen report for tank AP-104. Evaporator candidate feed from tank 241-AP-104 (hereafter referred to as AP-104) was characterized for physical, inorganic, organic and radiochemical parameters by the Westinghouse Hanford Company, 222-S Laboratory, and by the Battelle Pacific Northwest National Laboratory (PNNL), Analytical Chemistry Laboratory (ACL) as directed by the Tank Sample and Analysis Plan (TSAP), References 1 through 4. Preliminary data in the form of summary analytical tables were provided to the project in advance of this final report tomore » enable early estimation of evaporator operational parameters, using the Predict modeling program. Laboratory analyses at ACL Laboratory was performed according to the TSAP. Analyses were performed at the 222-S Laboratory as defined and specified in the TSAP and the Laboratory`s Quality Assurance Plan, References 5 and 6. Any deviations from the instructions documented in the TSAP are discussed in this narrative and are supported with additional documentation. SAMPLING The TSAP, section 2, provided sampling information for waste samples collected from tank AP-104. The bottle-on-a-string method was used to collect liquid grab samples from the tank. Each glass sample bottle was amber, precleaned, and contained approximately 100 milliliters. Each bottle was closed with a teflon seal cap (or teflon septum for volatile organic analysis samples). Field blank samples were prepared by placing deionized water into sampling bottles, lowering the unclosed bottles into the riser for a period of time, retrieving them from the riser, and then closing the bottles with the same types of caps used for the tank samples. None of the samples were preserved by acidification. Upon receipt, the sample bottles destined for organic analyses were placed in a refrigerator. No attempt was made during sampling to assure the complete filling of the bottles so as to exclude all headspace. These actions were consistent with safety procedures, which attempt to limit personnel exposure to hazardous ionizing radiation.« less

  16. Hanford waste-form release and sediment interaction: A status report with rationale and recommendations for additional studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Serne, R.J.; Wood, M.I.

    1990-05-01

    This report documents the currently available geochemical data base for release and retardation for actual Hanford Site materials (wastes and/or sediments). The report also recommends specific laboratory tests and presents the rationale for the recommendations. The purpose of this document is threefold: to summarize currently available information, to provide a strategy for generating additional data, and to provide recommendations on specific data collection methods and tests matrices. This report outlines a data collection approach that relies on feedback from performance analyses to ascertain when adequate data have been collected. The data collection scheme emphasizes laboratory testing based on empiricism. 196more » refs., 4 figs., 36 tabs.« less

  17. [Building and implementation of management system in laboratories of the National Institute of Hygiene].

    PubMed

    Rozbicka, Beata; Brulińska-Ostrowska, Elzbieta

    2008-01-01

    The rules of good laboratory practice have always been observed in the laboratories of National Institute of Hygiene (NIH) and the reliability of the results has been carefully cared after when performing tests for clients. In 2003 the laboratories performing analyses related to food safety were designated as the national reference laboratories. This, added to the necessity of compliance with work standards and requirements of EU legislation and to the need of confirmation of competence by an independent organisation, led to a decision to seek accreditation of Polish Centre of Accreditation (PCA). The following stages of building and implementation of management system were presented: training, modifications of Institute's organisational structure, elaboration of management system's documentation, renovation and refurbishment of laboratory facilities, implementation of measuring and test equipment's supervision, internal audits and management review. The importance of earlier experiences and achievements with regard to validation of analytical methods and guarding of the quality of the results through organisation and participation in proficiency tests was highlighted. Current status of accreditation of testing procedures used in NIH laboratories that perform analyses in the field of chemistry, microbiology, radiobiology and medical diagnostic tests was presented.

  18. Enhanced Verification Test Suite for Physics Simulation Codes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamm, J R; Brock, J S; Brandon, S T

    2008-10-10

    This document discusses problems with which to augment, in quantity and in quality, the existing tri-laboratory suite of verification problems used by Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratories (SNL). The purpose of verification analysis is demonstrate whether the numerical results of the discretization algorithms in physics and engineering simulation codes provide correct solutions of the corresponding continuum equations. The key points of this document are: (1) Verification deals with mathematical correctness of the numerical algorithms in a code, while validation deals with physical correctness of a simulation in a regime of interest.more » This document is about verification. (2) The current seven-problem Tri-Laboratory Verification Test Suite, which has been used for approximately five years at the DOE WP laboratories, is limited. (3) Both the methodology for and technology used in verification analysis have evolved and been improved since the original test suite was proposed. (4) The proposed test problems are in three basic areas: (a) Hydrodynamics; (b) Transport processes; and (c) Dynamic strength-of-materials. (5) For several of the proposed problems we provide a 'strong sense verification benchmark', consisting of (i) a clear mathematical statement of the problem with sufficient information to run a computer simulation, (ii) an explanation of how the code result and benchmark solution are to be evaluated, and (iii) a description of the acceptance criterion for simulation code results. (6) It is proposed that the set of verification test problems with which any particular code be evaluated include some of the problems described in this document. Analysis of the proposed verification test problems constitutes part of a necessary--but not sufficient--step that builds confidence in physics and engineering simulation codes. More complicated test cases, including physics models of greater sophistication or other physics regimes (e.g., energetic material response, magneto-hydrodynamics), would represent a scientifically desirable complement to the fundamental test cases discussed in this report. The authors believe that this document can be used to enhance the verification analyses undertaken at the DOE WP Laboratories and, thus, to improve the quality, credibility, and usefulness of the simulation codes that are analyzed with these problems.« less

  19. Trace-element analyses of core samples from the 1967-1988 drillings of Kilauea Iki lava lake, Hawaii

    USGS Publications Warehouse

    Helz, Rosalind Tuthill

    2012-01-01

    This report presents previously unpublished analyses of trace elements in drill core samples from Kilauea Iki lava lake and from the 1959 eruption that fed the lava lake. The two types of data presented were obtained by instrumental neutron-activation analysis (INAA) and energy-dispersive X-ray fluorescence analysis (EDXRF). The analyses were performed in U.S. Geological Survey (USGS) laboratories from 1989 to 1994. This report contains 93 INAA analyses on 84 samples and 68 EDXRF analyses on 68 samples. The purpose of the study was to document trace-element variation during chemical differentiation, especially during the closed-system differentiation of Kilauea Iki lava lake.

  20. SCALE: A modular code system for performing standardized computer analyses for licensing evaluation. Functional modules F1--F8 -- Volume 2, Part 1, Revision 4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Greene, N.M.; Petrie, L.M.; Westfall, R.M.

    SCALE--a modular code system for Standardized Computer Analyses Licensing Evaluation--has been developed by Oak Ridge National Laboratory at the request of the US Nuclear Regulatory Commission. The SCALE system utilizes well-established computer codes and methods within standard analysis sequences that (1) allow an input format designed for the occasional user and/or novice, (2) automate the data processing and coupling between modules, and (3) provide accurate and reliable results. System development has been directed at problem-dependent cross-section processing and analysis of criticality safety, shielding, heat transfer, and depletion/decay problems. Since the initial release of SCALE in 1980, the code system hasmore » been heavily used for evaluation of nuclear fuel facility and package designs. This revision documents Version 4.2 of the system. The manual is divided into three volumes: Volume 1--for the control module documentation; Volume 2--for functional module documentation; and Volume 3--for documentation of the data libraries and subroutine libraries.« less

  1. Nuclear security

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dingell, J.D.

    1991-02-01

    The Department of Energy's (DOE) Lawrence Livermore National Laboratory, located in Livermore, California, generates and controls large numbers of classified documents associated with the research and testing of nuclear weapons. Concern has been raised about the potential for espionage at the laboratory and the national security implications of classified documents being stolen. This paper determines the extent of missing classified documents at the laboratory and assesses the adequacy of accountability over classified documents in the laboratory's custody. Audit coverage was limited to the approximately 600,000 secret documents in the laboratory's custody. The adequacy of DOE's oversight of the laboratory's secretmore » document control program was also assessed.« less

  2. Results of initial analyses of the salt (macro) batch 10 tank 21H qualification samples

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.

    2017-01-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 10 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 10 composite sample indicates that the material does not display any unusual characteristics or observations, such as floating solids, the presence of large amount of solids, or unusual colors. Further sample results will be reported in a futuremore » document. This memo satisfies part of Deliverable 3 of the Technical Task Request (TTR).« less

  3. Results of initial analyses of the salt (macro) batch 11 Tank 21H qualification samples

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 11 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 11 composite sample indicates that the material does not display any unusual characteristics or observations, such as floating solids, the presence of large amounts of solids, or unusual colors. Further sample results will be reported in a futuremore » document. This memo satisfies part of Deliverable 3 of the Technical Task Request (TTR).« less

  4. Laboratory Directed Research and Development Program FY98

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, T.; Chartock, M.

    1999-02-05

    The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL or Berkeley Lab) Laboratory Directed Research and Development Program FY 1998 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The LBNL LDRD program is a critical tool for directing the Laboratory's forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program providesmore » the resources for LBNL scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances LBNL's core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. All projects are work in forefront areas of science and technology. Areas eligible for support include the following: Advanced study of hypotheses, concepts, or innovative approaches to scientific or technical problems; Experiments and analyses directed toward ''proof of principle'' or early determination of the utility of new scientific ideas, technical concepts, or devices; and Conception and preliminary technical analyses of experimental facilities or devices.« less

  5. USACE Extreme Sea levels

    DTIC Science & Technology

    2014-03-14

    with expected changes due to climate change. (tropicals and extra-tropicals) Ivan provided some good information on work being done on tropical...Pattiaratchi, C., Jensen, J., 2013. Estimating extreme water level probabilities: a comparison of the direct methods and recommendations for best practise ...sites: site-by-site analyses. Proudman Oceanographic Laboratory , Internal Document, No. 65, 229pp. Dixon, M.J., Tawn, J.A. (1995) Extreme sea-levels

  6. Improving the Plasticity of LIMS Implementation: LIMS Extension through Microsoft Excel

    NASA Technical Reports Server (NTRS)

    Culver, Mark

    2017-01-01

    A Laboratory Information Management System (LIMS) is a databasing software with many built-in tools ideal for handling and documenting most laboratory processes in an accurate and consistent manner, making it an indispensable tool for the modern laboratory. However, a lot of LIMS end users will find that in the performance of analyses that have unique considerations such as standard curves, multiple stages incubations, or logical considerations, a base LIMS distribution may not ideally suit their needs. These considerations bring about the need for extension languages, which can extend the functionality of a LIMS. While these languages do provide the implementation team the functionality required to accommodate these special laboratory analyses, they are usually too complex for the end user to modify to compensate for natural changes in laboratory operations. The LIMS utilized by our laboratory offers a unique and easy-to-use choice for an extension language, one that is already heavily relied upon not only in science but also in most academic and business pursuits: Microsoft Excel. The validity of Microsoft Excel as a pseudo programming language and its usability and versatility as a LIMS extension language will be discussed. The NELAC implications and overall drawbacks of this LIMS configuration will also be discussed.

  7. Hanford analytical sample projections FY 1998--FY 2002

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joyce, S.M.

    1998-02-12

    Analytical Services projections are compiled for the Hanford site based on inputs from the major programs for the years 1998 through 2002. Projections are categorized by radiation level, protocol, sample matrix and program. Analyses requirements are also presented. This document summarizes the Hanford sample projections for fiscal years 1998 to 2002. Sample projections are based on inputs submitted to Analytical Services covering Environmental Restoration, Tank Waste Remediation Systems (TWRS), Solid Waste, Liquid Effluents, Spent Nuclear Fuels, Transition Projects, Site Monitoring, Industrial Hygiene, Analytical Services and miscellaneous Hanford support activities. In addition, details on laboratory scale technology (development) work, Sample Management,more » and Data Management activities are included. This information will be used by Hanford Analytical Services (HAS) and the Sample Management Working Group (SMWG) to assure that laboratories and resources are available and effectively utilized to meet these documented needs.« less

  8. LANL Environmental ALARA Program Status Report for CY 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whicker, Jeffrey Jay; Mcnaughton, Michael; Ruedig, Elizabeth

    2017-02-24

    Los Alamos National Laboratory (LANL) ensures that radiation exposures to members of the public and the environment from LANL operations, past and present, are below regulatory thresholds and are as low as reasonably achievable (ALARA) through compliance with DOE Order 458.1 Radiation Protection for the Public and the Environment, and LANL Policy 412 Environmental Radiation Protection (LANL2016a). In 2007, a finding (RL.2-F-1) and observation (RL.2-0-1) in the NNSA/ LASO report, September 2007, Release of Property (Land) Containing Residual Radioactive Material Self-Assessment Report, indicated that LANL had no policy or documented process in place for the release of property containing residualmore » radioactive material. In response, LANL developed PD410, Los Alamos National Laboratory Environmental ALARA Program. The most recent version of this document became effective in 2014 (LANL 2014a). The document provides program authorities, responsibilities, descriptions, processes, and thresholds for conducting qualitative and quantitative ALARA analyses for prospective and actual radiation exposures to the public and t o the environment resulting from DOE activities conducted on the LANL site.« less

  9. LANL Environmental ALARA Program Status Report for CY 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whicker, Jeffrey Jay; Mcnaughton, Michael; Gillis, Jessica Mcdonnel

    2016-03-29

    Los Alamos National Laboratory (LANL) ensures that radiation exposures to members of the public and the environment from LANL operations, past and present, are below regulatory thresholds and are as low as reasonably achievable (ALARA) through compliance with DOE Order 458.1 Radiation Protection for the Public and the Environment, and LANL Policy 412 Environmental Radiation Protection. In 2007, a finding (RL.2-F-1) and observation (RL.2-0-1) in the NNSA/ LASO report, September 2007, Release of Property (Land) Containing Residual Radioactive Material Self-Assessment Report, indicated that LANL had no policy or documented process in place for the release of property containing residual radioactivemore » material. In response, LANL developed PD410, Los Alamos National Laboratory Environmental ALARA Program. The most recent version of this document became effective on September 28, 2011. The document provides program authorities, responsibilities, descriptions, processes, and thresholds for conducting qualitative and quantitative ALARA analyses for prospective and actual radiation exposures to the public and t o the environment resulting from DOE activities conducted on the LANL site.« less

  10. Parameters for determining inoculated pack/challenge study protocols.

    PubMed

    2010-01-01

    The National Advisory Committee on Microbiological Criteria for Foods developed guidelines for conducting challenge studies on pathogen inhibition and inactivation studies in a variety of foods. The document is intended for use by the food industry, including food processors, food service operators, and food retailers; federal, state, and local food safety regulators; public health officials; food testing laboratories; and process authorities. The document is focused on and limited to bacterial inactivation and growth inhibition and does not make specific recommendations with respect to public health. The Committee concluded that challenge studies should be designed considering the most current advances in methodologies, current thinking on pathogens of concern, and an understanding of the product preparation, variability, and storage conditions. Studies should be completed and evaluated under the guidance of an expert microbiologist in a qualified laboratory and should include appropriate statistical design and data analyses. This document provides guidelines for choice of microorganisms for studies, inoculum preparation, inoculum level, methods of inoculation, incubation temperatures and times, sampling considerations, and interpreting test results. Examples of appropriately designed growth inhibition and inactivation studies are provided.

  11. Ergonomics investigation of retail ice cream operations.

    PubMed

    Dempsey, P G; McGorry, R R; Cotnam, J; Braun, T W

    2000-04-01

    A comprehensive ergonomics evaluation of retail ice cream shops, including field and laboratory data collection, was conducted using a human:workplace model approach to ergonomics practice. The goal of the evaluation was to provide recommendations to enhance the health, safety, and productivity of shop employees. Active and passive surveillance and facility walk-throughs were used to guide the selection of analyses. A primary focus of the investigation was quantifying the task demands of scooping ice cream, which have not been documented in the literature. This goal was accomplished through the use of a custom-designed instrumented ice cream scoop. Data were collected at an ice cream shop under typical conditions, while the laboratory experiment investigated task demands of ice cream scooping over a range of realistic temperatures. Manual materials handling task analyses and anthropometric evaluations comprised the majority of other analyses performed. Recommendations are presented that are applicable to the operation of retail ice cream shops that serve hard (i.e., scooped) ice cream.

  12. Manager's handbook for software development, revision 1

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Methods and aids for the management of software development projects are presented. The recommendations are based on analyses and experiences of the Software Engineering Laboratory (SEL) with flight dynamics software development. The management aspects of the following subjects are described: organizing the project, producing a development plan, estimating costs, scheduling, staffing, preparing deliverable documents, using management tools, monitoring the project, conducting reviews, auditing, testing, and certifying.

  13. Software engineering laboratory series: Annotated bibliography of software engineering laboratory literature

    NASA Technical Reports Server (NTRS)

    Morusiewicz, Linda; Valett, Jon

    1992-01-01

    This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: (1) the Software Engineering Laboratory; (2) the Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. This document contains an index of these publications classified by individual author.

  14. Annotated bibliography of Software Engineering Laboratory literature

    NASA Technical Reports Server (NTRS)

    Morusiewicz, Linda; Valett, Jon

    1993-01-01

    This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. Nearly 200 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: the Software Engineering Laboratory; the Software Engineering Laboratory: software development documents; software tools; software models; software measurement; technology evaluations; Ada technology; and data collection. This document contains an index of these publications classified by individual author.

  15. Guidelines for the identification of unknown samples for laboratories performing forensic analyses for chemical terrorism.

    PubMed

    Magnuson, Matthew L; Satzger, R Duane; Alcaraz, Armando; Brewer, Jason; Fetterolf, Dean; Harper, Martin; Hrynchuk, Ronald; McNally, Mary F; Montgomery, Madeline; Nottingham, Eric; Peterson, James; Rickenbach, Michael; Seidel, Jimmy L; Wolnik, Karen

    2012-05-01

    Since the early 1990s, the FBI Laboratory has sponsored Scientific Working Groups to improve discipline practices and build consensus among the forensic community. The Scientific Working Group on the Forensic Analysis of Chemical, Biological, Radiological and Nuclear Terrorism developed guidance, contained in this document, on issues forensic laboratories encounter when accepting and analyzing unknown samples associated with chemical terrorism, including laboratory capabilities and analytical testing plans. In the context of forensic analysis of chemical terrorism, this guidance defines an unknown sample and addresses what constitutes definitive and tentative identification. Laboratory safety, reporting issues, and postreporting considerations are also discussed. Utilization of these guidelines, as part of planning for forensic analysis related to a chemical terrorism incident, may help avoid unfortunate consequences not only to the public but also to the laboratory personnel. 2011 American Academy of Forensic Sciences. Published 2011. This article is a U.S. Government work and is in the public domain in the U.S.A.

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poloski, Adam P.; Wells, Beric E.; Tingey, Joel M.

    The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment and Immobilization Plant (WTP) will process and treat radioactive waste that is stored in tanks at the Hanford Site. Piping, pumps, and mixing vessels have been selected to transport, store, and mix the high-level waste slurries in the WTP. This report addresses the analyses performed by the Rheology Working Group (RWG) and Risk Assessment Working Group composed of Pacific Northwest National Laboratory (PNNL), Bechtel National Inc. (BNI), CH2M HILL, DOE Office of River Protection (ORP) and Yasuo Onishi Consulting, LLC staff on data obtained from documented Hanford wastemore » analyses to determine a best-estimate of the rheology of the Hanford tank wastes and their settling behavior. The actual testing activities were performed and reported separately in referenced documentation. Because of this, many of the required topics below do not apply and are so noted.« less

  17. Results Of Initial Analyses Of The Salt (Macro) Batch 9 Tank 21H Qualification Samples

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T.

    2015-10-08

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 9 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 9 composite sample indicates that the material does not display any unusual characteristics. Further results on the chemistry and other tests will be issued in the future.

  18. Annotated bibliography of software engineering laboratory literature

    NASA Technical Reports Server (NTRS)

    Kistler, David; Bristow, John; Smith, Don

    1994-01-01

    This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. Nearly 200 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: (1) The Software Engineering Laboratory; (2) The Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. This document contains an index of these publications classified by individual author.

  19. Recommended HSE-7 documents hierarchy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klein, R.B.; Jennrich, E.A.; Lund, D.M.

    1990-12-12

    This report recommends a hierarchy of waste management documents at Los Alamos National Laboratory (LANL or Laboratory''). The hierarchy addresses documents that are required to plan, implement, and document waste management programs at Los Alamos. These documents will enable the waste management group and the six sections contained within that group to satisfy requirements that are imposed upon them by the US Department of Energy (DOE), DOE Albuquerque Operations, US Environmental Protection Agency, various State of New Mexico agencies, and Laboratory management.

  20. Recommended HSE-7 documents hierarchy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klein, R.B.; Jennrich, E.A.; Lund, D.M.

    1990-12-12

    This report recommends a hierarchy of waste management documents at Los Alamos National Laboratory (LANL or ``Laboratory``). The hierarchy addresses documents that are required to plan, implement, and document waste management programs at Los Alamos. These documents will enable the waste management group and the six sections contained within that group to satisfy requirements that are imposed upon them by the US Department of Energy (DOE), DOE Albuquerque Operations, US Environmental Protection Agency, various State of New Mexico agencies, and Laboratory management.

  1. Annotated bibliography of software engineering laboratory literature

    NASA Technical Reports Server (NTRS)

    Groves, Paula; Valett, Jon

    1990-01-01

    An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is given. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: the Software Engineering Laboratory; the Software Engineering Laboratory-software development documents; software tools; software models; software measurement; technology evaluations; Ada technology; and data collection. Subject and author indexes further classify these documents by specific topic and individual author.

  2. Non-structural Components influencing Hospital Disaster Preparedness in Malaysia

    NASA Astrophysics Data System (ADS)

    Samsuddin, N. M.; Takim, R.; Nawawi, A. H.; Rosman, M. R.; SyedAlwee, S. N. A.

    2018-04-01

    Hospital disaster preparedness refers to measures taken by the hospital’s stakeholders to prepare, reduce the effects of disaster and ensure effective coordination during incident response. Among the measures, non-structural components (i.e., medical laboratory equipment & supplies; architectural; critical lifeline; external; updated building document; and equipment & furnishing) are critical towards hospital disaster preparedness. Nevertheless, over the past few years these components are badly affected due to various types of disasters. Hence, the objective of this paper is to investigate the non-structural components influencing hospital’s disaster preparedness. Cross-sectional survey was conducted among thirty-one (31) Malaysian hospital’s employees. A total of 6 main constructs with 107 non-structural components were analysed and ranked by using SPSS and Relative Importance Index (RII). The results revealed that 6 main constructs (i.e. medical laboratory equipment & supplies; architectural; critical lifeline; external; updated building document; and equipment & furnishing) are rated as ‘very critical’ by the respondents. Among others, availability of medical laboratory equipment and supplies for diagnostic and equipment was ranked first. The results could serve as indicators for the public hospitals to improve its disaster preparedness in terms of planning, organising, knowledge training, equipment, exercising, evaluating and corrective actions through non-structural components.

  3. Sampling and analysis plan for sludge located on the floor and in the pits of the 105-K basins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    BAKER, R.B.

    1998-11-20

    This Sampling and Analysis Plan (SAP) provides direction for the sampling of the sludge found on the floor and in the remote pits of the 105-K Basins to provide: (1) basic data for the sludges that have not been characterized to-date and (2) representative Sludge material for process tests to be made by the SNF Project/K Basins sludge treatment process subproject. The sampling equipment developed will remove representative samples of the radioactive sludge from underwater at the K Basins, depositing them in shielded containers for transport to the Hanford Site laboratories. Included in the present document is the basic backgroundmore » logic for selection of the samples to meet the requirements established in the Data Quality Objectives (DQO), HNF-2033, for this sampling activity. The present document also includes the laboratory analyses, methods, procedures, and reporting that will be required to meet the DQO.« less

  4. Tank 241-AZ-102 Privatization Push Mode Core Sampling and Analysis Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    RASMUSSEN, J.H.

    1999-08-02

    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AZ-102. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AZ-102 required to satisfy the Data Quality Objectives For TWRS Privatization Phase I: Confirm Tank TIS An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO) (Nguyen 1999a), Data Quality Objectives For TWRS Privatization Phase 1: Confirm Tank TIS An Appropriate Feed Source For Low-Activity Waste Feed Batch X (LAW DQO) (Nguyen 1999b), Low Activity Waste andmore » High Level Waste Feed Data Quality Objectives (L&H DQO) (Patello et al. 1999) and Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO) (Bloom 1996). The Tank Characterization Technical Sampling Basis document (Brown et al. 1998) indicates that these issues, except the Equipment DQO apply to tank 241-AZ-102 for this sampling event. The Equipment DQO is applied for shear strength measurements of the solids segments only. Poppiti (1999) requires additional americium-241 analyses of the sludge segments. Brown et al. (1998) also identify safety screening, regulatory issues and provision of samples to the Privatization Contractor(s) as applicable issues for this tank. However, these issues will not be addressed via this sampling event. Reynolds et al. (1999) concluded that information from previous sampling events was sufficient to satisfy the safety screening requirements for tank 241 -AZ-102. Push mode core samples will be obtained from risers 15C and 24A to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples, composite the liquids and solids, perform chemical analyses, and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AZ-102 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plan.« less

  5. Annotated bibliography of Software Engineering Laboratory literature

    NASA Technical Reports Server (NTRS)

    Morusiewicz, Linda; Valett, Jon D.

    1991-01-01

    An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is given. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. All materials have been grouped into eight general subject areas for easy reference: The Software Engineering Laboratory; The Software Engineering Laboratory: Software Development Documents; Software Tools; Software Models; Software Measurement; Technology Evaluations; Ada Technology; and Data Collection. Subject and author indexes further classify these documents by specific topic and individual author.

  6. [Point-of-care-testing--the intensive care laboratory].

    PubMed

    Müller, M M; Hackl, W; Griesmacher, A

    1999-01-01

    After successful centralization of laboratory analyses since more than 30 years, advances in biosensors, microprocessors, measurement of undiluted whole blood and miniaturization of laboratory analyzers are leading nowadays more and more to a re-decentralization in the laboratory medicine. Point-of-care-testing (POCT), which is defined as any laboratory test performed outside central or decentralized laboratories, is becoming more and more popular. The theoretical advantages of POCT are faster turn-around-times (TAT), more rapid medical decisions, avoidance of sample identification and sample transport problems and the need of only small specimen volumes. These advantages are frequently mentioned, but are not associated with a clear clinical benefit. The disadvantages of POCT such as incorrect handling and/or maintenance of the analyzers by nontrained clinical staff, inadequate or even absent calibrations and/or quality controls, lack of cost-effectiveness because of an increased number of analyzers and more expensive reagents, insufficient documentation and difficult comparability of the obtained POCT-results with routine laboratory results, are strongly evident. According to the authors' opinion the decision for the establishing of POCT has only to be made in a close co-operation between physicians and laboratorians in order to vouch for necessity and high quality of the analyses. Taking the local situation into consideration (24-h-central laboratory, etc.) the spectrum of parameters measured by means of POCT should be rigorously restricted to the vital functions. Such analytes should be: hemoglobin or hematocrit, activated whole blood clotting time, blood gases, sodium, potassium, ionized calcium, glucose, creatinine, ammonia and lactate.

  7. Microbiological methods for the water recovery systems test, revision 1.1

    NASA Technical Reports Server (NTRS)

    Rhoads, Tim; Kilgore, M. V., Jr.; Mikell, A. T., Jr.

    1990-01-01

    Current microbiological parameters specified to verify microbiological quality of Space Station Freedom water quality include the enumeration of total bacteria, anaerobes, aerobes, yeasts and molds, enteric bacteria, gram positives, gram negatives, and E. coli. In addition, other parameters have been identified as necessary to support the Water Recovery Test activities to be conducted at the NASA/MSFC later this year. These other parameters include aerotolerant eutrophic mesophiles, legionellae, and an additional method for heterotrophic bacteria. If inter-laboratory data are to be compared to evaluate quality, analytical methods must be eliminated as a variable. Therefore, each participating laboratory must utilize the same analytical methods and procedures. Without this standardization, data can be neither compared nor validated between laboratories. Multiple laboratory participation represents a conservative approach to insure quality and completeness of data. Invariably, sample loss will occur in transport and analyses. Natural variance is a reality on any test of this magnitude and is further enhanced because biological entities, capable of growth and death, are specific parameters of interest. The large variation due to the participation of human test subjects has been noted with previous testing. The resultant data might be dismissed as 'out of control' unless intra-laboratory control is included as part of the method or if participating laboratories are not available for verification. The purpose of this document is to provide standardized laboratory procedures for the enumeration of certain microorganisms in water and wastewater specific to the water recovery systems test. The document consists of ten separate cultural methods and one direct count procedure. It is not intended nor is it implied to be a complete microbiological methods manual.

  8. [On the way to national reference system of laboratory medicine].

    PubMed

    Muravskaia, N P; Men'shikov, V V

    2014-10-01

    The application of standard samples and reference techniques of implementation of measurements is needed for a valid support of reliability of analyses applied in clinical diagnostic laboratories. They play role of landmarks under metrologic monitoring, calibration of devices and control of quality of results. The article presents analysis of shortcomings interfering with formation of national reference system in Russia harmonized with possibilities provided by international organizations. Among them are the joint Committee on metrologic monitoring in laboratory medicine under the auspices of the International Bureau of Weights and Measures, the International Federation of clinical chemistry and laboratory medicine, etc. The results of the recent development of national normative documents, standard samples and techniques assisted by the authors of article are considered. They are the first steps to organization of national reference system which would comprise all range of modern analytical technologies of laboratory medicine. The national and international measures are proposed to enhance the promptest resolving of task of organization of national reference system for laboratory medicine in the interests of increasing of effectiveness of medical care to citizen of Russia.

  9. Guide to data collection

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Guidelines and recommendations are presented for the collection of software development data. Motivation and planning for, and implementation and management of, a data collection effort are discussed. Topics covered include types, sources, and availability of data; methods and costs of data collection; types of analyses supported; and warnings and suggestions based on software engineering laboratory (SEL) experiences. This document is intended as a practical guide for software managers and engineers, abstracted and generalized from 5 years of SEL data collection.

  10. NLS Flight Simulation Laboratory (FSL) documentation

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Flight Simulation Laboratory (FSL) Electronic Documentation System design consists of modification and utilization of the MSFC Integrated Engineering System (IES), translation of the existing FSL documentation to an electronic format, and generation of new drawings to represent the Engine Flight Simulation Laboratory design and implementation. The intent of the electronic documentation is to provide ease of access, local print/plot capabilities, as well as the ability to correct and/or modify the stored data by network users who are authorized to access this information.

  11. A Numerical Method for Computing the Transonic Fan Duct Flow over a Centerbody into an Exterior Free Stream - Program Tea-343,

    DTIC Science & Technology

    1974-09-24

    Transonic Flows with Imbedded Shock Waves", Boeing Scientific Research Laboratories Document D1-82-1053 (1971); also as invited lecture series for AGARD...Past Thin Lifting Airfoils", Boeing Scientific Research Laboratories Document D180-2298-1, June 1971. 5. Krupp, J. A. and Ia-man, 9. M., "Computation...Aerodynamics and Marine Sciences Laboratory, Boeing Scientific Research Laboratories, June 1971. 7. Krupp, J. A., "Documentation for Program TSONIC", Technical

  12. Quality-assurance plan for the analysis of suspended sediment by the U.S. Geological Survey in Montana

    USGS Publications Warehouse

    Dodge, Kent A.; Lambing, John H.

    2006-01-01

    A quality-assurance plan has been developed for use by the sediment laboratory of the U.S. Geological Survey Montana Water Science Center in conducting activities related to the analysis of suspended sediment. The plan documents quality-assurance policies for sediment-laboratory certification, personnel responsibilities and training, documentation requirements, and laboratory safety. The plan also documents quality-assurance procedures related to laboratory equipment and supplies, sample management, sample analysis, analytical quality control, and data management.

  13. 222-S Laboratory Quality Assurance Plan. Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meznarich, H.K.

    1995-07-31

    This Quality Assurance Plan provides,quality assurance (QA) guidance, regulatory QA requirements (e.g., 10 CFR 830.120), and quality control (QC) specifications for analytical service. This document follows the U.S Department of Energy (DOE) issued Hanford Analytical Services Quality Assurance Plan (HASQAP). In addition, this document meets the objectives of the Quality Assurance Program provided in the WHC-CM-4-2, Section 2.1. Quality assurance elements required in the Guidelines and Specifications for Preparing Quality Assurance Program Plans (QAMS-004) and Interim Guidelines and Specifications for Preparing Quality Assurance Project Plans (QAMS-005) from the US Environmental Protection Agency (EPA) are covered throughout this document. A qualitymore » assurance index is provided in the Appendix A. This document also provides and/or identifies the procedural information that governs laboratory operations. The personnel of the 222-S Laboratory and the Standards Laboratory including managers, analysts, QA/QC staff, auditors, and support staff shall use this document as guidance and instructions for their operational and quality assurance activities. Other organizations that conduct activities described in this document for the 222-S Laboratory shall follow this QA/QC document.« less

  14. Results and analysis of saltstone cores taken from saltstone disposal unit cell 2A

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reigel, M. M.; Hill, K. A.

    2016-03-01

    As part of an ongoing Performance Assessment (PA) Maintenance Plan, Savannah River Remediation (SRR) has developed a sampling and analyses strategy to facilitate the comparison of field-emplaced samples (i.e., saltstone placed and cured in a Saltstone Disposal Unit (SDU)) with samples prepared and cured in the laboratory. The primary objectives of the Sampling and Analyses Plan (SAP) are; (1) to demonstrate a correlation between the measured properties of laboratory-prepared, simulant samples (termed Sample Set 3), and the field-emplaced saltstone samples (termed Sample Set 9), and (2) to validate property values assumed for the Saltstone Disposal Facility (SDF) PA modeling. Themore » analysis and property data for Sample Set 9 (i.e. six core samples extracted from SDU Cell 2A (SDU2A)) are documented in this report, and where applicable, the results are compared to the results for Sample Set 3. Relevant properties to demonstrate the aforementioned objectives include bulk density, porosity, saturated hydraulic conductivity (SHC), and radionuclide leaching behavior.« less

  15. Tank 241-T-204, core 188 analytical results for the final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nuzum, J.L.

    TANK 241-T-204, CORE 188, ANALYTICAL RESULTS FOR THE FINAL REPORT. This document is the final laboratory report for Tank 241 -T-204. Push mode core segments were removed from Riser 3 between March 27, 1997, and April 11, 1997. Segments were received and extruded at 222-8 Laboratory. Analyses were performed in accordance with Tank 241-T-204 Push Mode Core Sampling and analysis Plan (TRAP) (Winkleman, 1997), Letter of instruction for Core Sample Analysis of Tanks 241-T-201, 241- T-202, 241-T-203, and 241-T-204 (LAY) (Bell, 1997), and Safety Screening Data Qual@ Objective (DO) ODukelow, et al., 1995). None of the subsamples submitted for totalmore » alpha activity (AT) or differential scanning calorimetry (DC) analyses exceeded the notification limits stated in DO. The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group and are not considered in this report.« less

  16. Using synchrotron X-ray microtomography to characterize the pore network of reservoir rocks: A case study on carbonates

    NASA Astrophysics Data System (ADS)

    Arzilli, F.; Cilona, A.; Mancini, L.; Tondi, E.

    2016-09-01

    In this work we propose a new methodology to calculate pore connectivity in granular rocks. This method is useful to characterize the pore networks of natural and laboratory compaction bands (CBs), and compare them with the host rock pore network. Data were collected using the synchrotron X-ray microtomography technique and quantitative analyses were carried out using the Pore3D software library. The porosity was calculated from segmented tridimensional images of deformed and pristine rocks. A process of skeletonization of the pore space was used to obtain the number of connected pores within the rock volume. By analyzing the skeletons the differences between natural and laboratory CBs were highlighted. The natural CB has a lower porosity than to the laboratory one. In natural CBs, the grain contacts appear welded, whereas laboratory CBs show irregular pore shape. Moreover, we assessed for the first time how pore connectivity evolves as a function of deformation, documenting the mechanism responsible for pore connectivity drop within the CBs.

  17. Tank 241-U-103, grab samples 3U-99-1, 3u-99-2 and 3U-99-3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    STEEN, F.H.

    This document is the final report for tank 241-U-103 grab samples. Three grab samples were collected from riser 13 on March 12, 1999 and received by the 222-S laboratory on March 15, 1999. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan for Fiscal year 1999 (TSAP) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO). The analytical results are presented in the data summary report. None of the subsamples submitted for differential scanning calorimetry (DSC), total organic carbon (TOC) and plutonium 239 (Pu239) analyses exceeded the notification limits as stated in TSAP.

  18. Doping control analysis at the Rio 2016 Olympic and Paralympic Games.

    PubMed

    Pereira, Henrique Marcelo Gualberto; Sardela, Vinicius Figueiredo; Padilha, Monica Costa; Mirotti, Luciana; Casilli, Alessandro; de Oliveira, Fabio Azamor; de Albuquerque Cavalcanti, Gustavo; Rodrigues, Lucas Martins Lisandro; de Araujo, Amanda Lessa Dutra; Levy, Rachel Santos; Teixeira, Pedro Antonio Castelo; de Oliveira, Felipe Alves Gomes; Duarte, Ana Carolina Giordani; Carneiro, Ana Carolina Dudenhoeffer; Evaristo, Joseph Albert Medeiros; Dos Santos, Gustavo Ramalho Cardoso; da Costa, Giovanni Carlo Verissimo; de Lima Castro, Fernando; Nogueira, Fabio Cesar Sousa; Scalco, Fernanda Bertão; Pizzatti, Luciana; de Aquino Neto, Francisco Radler

    2017-11-01

    This paper summarises the results obtained from the doping control analyses performed during the Summer XXXI Olympic Games (August 3-21, 2016) and the XV Paralympic Games (September 7-18, 2016). The analyses of all doping control samples were performed at the Brazilian Doping Control Laboratory (LBCD), a World Anti-Doping Agency (WADA)-accredited laboratory located in Rio de Janeiro, Brazil. A new facility at Rio de Janeiro Federal University (UFRJ) was built and fully operated by over 700 professionals, including Brazilian and international scientists, administrative staff, and volunteers. For the Olympic Games, 4913 samples were analysed. In 29 specimens, the presence of a prohibited substance was confirmed, resulting in adverse analytical findings (AAFs). For the Paralympic Games, 1687 samples were analysed, 12 of which were reported as AAFs. For both events, 82.8% of the samples were urine, and 17.2% were blood samples. In total, more than 31 000 analytical procedures were conducted. New WADA technical documents were fully implemented; consequently, state-of-the-art analytical toxicology instrumentation and strategies were applied during the Games, including different types of mass spectrometry (MS) analysers, peptide, and protein detection strategies, endogenous steroid profile measurements, and blood analysis. This enormous investment yielded one of the largest Olympic legacies in Brazil and South America. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  19. Condition assessment of a highly porous limestone fortress: damage categories and structural integrity

    NASA Astrophysics Data System (ADS)

    Török, Ákos; Czinder, Balázs; Farkas, Orsolya; Görög, Péter; Kopecskó, Katalin; Lógó, János; Rozgonyi-Boissinot, Nikoletta; Vásárhelyi, Balázs

    2016-04-01

    An emblematic monument the Citadella fortress of Budapest has been studied in details to assess the condition of stone structure. The fortress is a large stone structure of 220 m in length and 60 m in width. The height of the porous limestone walls are in between 12-16 metres. The fortress was completed in 1854 but has been partly rebuilt due to changes in function and war related structural damages. The present paper provides an overview of the lithology, weathering forms and structural condition of the fortress related to a forthcoming restoration-reconstruction project. To assess the condition of stone both on site and laboratory analyses were performed. Lithological varieties were documented. Major identified lithotypes are porous oolitic limestone, less porous bioclastic limestone and fine grained highly porous limestone. To identify wet zones portable moisture meter was applied. Surface strength and weathering grade were also assessed using Schmidt hammer and Duroscop. Decay features were diagnosed and mapped. The most common forms are white weathering crusts, scaling and blistering of crusts as well as granular disintegration. Black weathering crusts were also recognized. Laboratory tests were focused on mechanical properties of stones and on mineralogical and chemical compositional analyses. Small samples of stone were collected and tested by optical microscopy, SEM-EDX, XRD and Thermogravimetric analyses. Laboratory analyses proved that the major salt responsible for the damage of external walls is gypsum, although significant amount of halite and hygroscopic salts were found both on the external walls and in the interior parts of the fortress. During structural analyses displacement of walls, tilting and major amount of cracks were recognized. Loss of material and subsidence also caused problems and at some places unstable wall sections were recognized.

  20. Annotated bibliography of software engineering laboratory literature

    NASA Technical Reports Server (NTRS)

    Buhler, Melanie; Valett, Jon

    1989-01-01

    An annotated bibliography is presented of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. The bibliography was updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials were grouped into eight general subject areas for easy reference: (1) The Software Engineering Laboratory; (2) The Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. Subject and author indexes further classify these documents by specific topic and individual author.

  1. Evaluation of the enterovirus laboratory surveillance system in Denmark, 2010 to 2013.

    PubMed

    Condell, Orla; Midgley, Sofie; Christiansen, Claus Bohn; Chen, Ming; Chen Nielsen, Xiaohui; Ellermann-Eriksen, Svend; Mølvadgaard, Mette; Schønning, Kristian; Vermedal Hoegh, Silje; Andersen, Peter Henrik; Voldstedlund, Marianne; Fischer, Thea Kølsen

    2016-05-05

    The primary aim of the Danish enterovirus (EV) surveillance system is to document absence of poliovirus infection. The conflict in Syria has left many children unvaccinated and movement from areas with polio cases to Europe calls for increased awareness to detect and respond to virus-transmission in a timely manner. We evaluate the national EV laboratory surveillance, to generate recommendations for system strengthening. The system was analysed for completeness of viral typing analysis and clinical information and timeliness of specimen collection, laboratory results and reporting of clinical information. Of 23,720 specimens screened, 2,202 (9.3%) were EV-positive. Submission of cerebrospinal fluid and faecal specimens from primary diagnostic laboratories was 79.5% complete (845/1,063), and varied by laboratory and patient age. EV genotypes were determined in 68.5% (979/1,430) of laboratory-confirmed cases, clinical information was available for 63.1% (903/1,430). Primary diagnostic results were available after a median of 1.4 days, typing results after 17 days, detailed clinical information after 33 days. The large number of samples typed demonstrated continued monitoring of EV-circulation in Denmark. The system could be strengthened by increasing the collection of supplementary faecal specimens, improving communication with primary diagnostic laboratories, adapting the laboratory typing methodology and collecting clinical information with electronic forms.

  2. Updated operational protocols for the U.S. Geological Survey Precipitation Chemistry Quality Assurance Project in support of the National Atmospheric Deposition Program

    USGS Publications Warehouse

    Wetherbee, Gregory A.; Martin, RoseAnn

    2017-02-06

    The U.S. Geological Survey Branch of Quality Systems operates the Precipitation Chemistry Quality Assurance Project (PCQA) for the National Atmospheric Deposition Program/National Trends Network (NADP/NTN) and National Atmospheric Deposition Program/Mercury Deposition Network (NADP/MDN). Since 1978, various programs have been implemented by the PCQA to estimate data variability and bias contributed by changing protocols, equipment, and sample submission schemes within NADP networks. These programs independently measure the field and laboratory components which contribute to the overall variability of NADP wet-deposition chemistry and precipitation depth measurements. The PCQA evaluates the quality of analyte-specific chemical analyses from the two, currently (2016) contracted NADP laboratories, Central Analytical Laboratory and Mercury Analytical Laboratory, by comparing laboratory performance among participating national and international laboratories. Sample contamination and stability are evaluated for NTN and MDN by using externally field-processed blank samples provided by the Branch of Quality Systems. A colocated sampler program evaluates the overall variability of NTN measurements and bias between dissimilar precipitation gages and sample collectors.This report documents historical PCQA operations and general procedures for each of the external quality-assurance programs from 2007 to 2016.

  3. International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants.

    PubMed

    Gosselin, Robert C; Adcock, Dorothy M; Bates, Shannon M; Douxfils, Jonathan; Favaloro, Emmanuel J; Gouin-Thibault, Isabelle; Guillermo, Cecilia; Kawai, Yohko; Lindhoff-Last, Edelgard; Kitchen, Steve

    2018-03-01

    This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH) for providing haemostasis-related guidance documents for clinical laboratories. This inaugural coagulation ICSH document was developed by an ad hoc committee, comprised of international clinical and laboratory direct acting oral anticoagulant (DOAC) experts. The committee developed consensus recommendations for laboratory measurement of DOACs (dabigatran, rivaroxaban, apixaban and edoxaban), which would be germane for laboratories assessing DOAC anticoagulation. This guidance document addresses all phases of laboratory DOAC measurements, including pre-analytical (e.g. preferred time sample collection, preferred sample type, sample stability), analytical (gold standard method, screening and quantifying methods) and post analytical (e.g. reporting units, quality assurance). The committee addressed the use and limitations of screening tests such as prothrombin time, activated partial thromboplastin time as well as viscoelastic measurements of clotting blood and point of care methods. Additionally, the committee provided recommendations for the proper validation or verification of performance of laboratory assays prior to implementation for clinical use, and external quality assurance to provide continuous assessment of testing and reporting method. Schattauer GmbH Stuttgart.

  4. Annotated bibliography of Software Engineering Laboratory literature

    NASA Technical Reports Server (NTRS)

    1985-01-01

    An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is presented. More than 100 publications are summarized. These publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials are grouped into five general subject areas for easy reference: (1) the software engineering laboratory; (2) software tools; (3) models and measures; (4) technology evaluations; and (5) data collection. An index further classifies these documents by specific topic.

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Prather, J. C.; Smith, S. K.; Watson, C. R.

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of themore » software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives.« less

  6. Laboratory Biosafety and Biosecurity Risk Assessment Technical Guidance Document

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Astuto-Gribble, Lisa M; Caskey, Susan Adele

    2014-07-01

    The purpose of this document is threefold: 1) to describe the laboratory bio safety and biosecurity risk assessment process and its conceptual framework; 2) provide detailed guidance and suggested methodologies on how to conduct a risk assessment; and 3) present some practical risk assessment process strategies using realistic laboratory scenarios.

  7. Guide for Training Medical Laboratory Technicians. Fourth Edition.

    ERIC Educational Resources Information Center

    American Medical Technologists, Park Ridge, IL.

    This document is intended to assist educators in the development of medical laboratory technician training programs. The following elements are included in the document: (1) an introduction; (2) the American Medical Technologists' Code of Ethics; (3) suggested curricula for medical laboratory technician programs for a 12-month course and an…

  8. Tank 241-AY-101 Privatization Push Mode Core Sampling and Analysis Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    TEMPLETON, A.M.

    2000-01-12

    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AY-101. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AY-101 required to satisfy Data Quality Objectives For RPP Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO) (Nguyen 1999a), Data Quality Objectives For TWRS Privatization Phase I : Confirm Tank T Is An Appropriate Feed Source For Low-Activity Waste Feed Batch X (LAW DQO) (Nguyen 1999b), Low Activitymore » Waste and High-Level Waste Feed Data Quality Objectives (L and H DQO) (Patello et al. 1999), and Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO) (Bloom 1996). Special instructions regarding support to the LAW and HLW DQOs are provided by Baldwin (1999). Push mode core samples will be obtained from risers 15G and 150 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples; composite the liquids and solids; perform chemical analyses on composite and segment samples; archive half-segment samples; and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AY-101 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plans and are not within the scope of this SAP.« less

  9. Tank 241-AY-101 Privatization Push Mode Core Sampling and Analysis Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    TEMPLETON, A.M.

    2000-05-19

    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AY-101. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AY-101 required to satisfy ''Data Quality Objectives For RPP Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO)' (Nguyen 1999a), ''Data Quality Objectives For TWRS Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For Low-Activity Waste Feed Butch X (LAW DQO) (Nguyen 1999b)'', ''Low Activity Wastemore » and High-Level Waste Feed Data Quality Objectives (L&H DQO)'' (Patello et al. 1999), and ''Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO)'' (Bloom 1996). Special instructions regarding support to the LAW and HLW DQOs are provided by Baldwin (1999). Push mode core samples will be obtained from risers 15G and 150 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples; composite the liquids and solids; perform chemical analyses on composite and segment samples; archive half-segment samples; and provide sub-samples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AY-101 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plans and are not within the scope of this SAP.« less

  10. Definition of an XML markup language for clinical laboratory procedures and comparison with generic XML markup.

    PubMed

    Saadawi, Gilan M; Harrison, James H

    2006-10-01

    Clinical laboratory procedure manuals are typically maintained as word processor files and are inefficient to store and search, require substantial effort for review and updating, and integrate poorly with other laboratory information. Electronic document management systems could improve procedure management and utility. As a first step toward building such systems, we have developed a prototype electronic format for laboratory procedures using Extensible Markup Language (XML). Representative laboratory procedures were analyzed to identify document structure and data elements. This information was used to create a markup vocabulary, CLP-ML, expressed as an XML Document Type Definition (DTD). To determine whether this markup provided advantages over generic markup, we compared procedures structured with CLP-ML or with the vocabulary of the Health Level Seven, Inc. (HL7) Clinical Document Architecture (CDA) narrative block. CLP-ML includes 124 XML tags and supports a variety of procedure types across different laboratory sections. When compared with a general-purpose markup vocabulary (CDA narrative block), CLP-ML documents were easier to edit and read, less complex structurally, and simpler to traverse for searching and retrieval. In combination with appropriate software, CLP-ML is designed to support electronic authoring, reviewing, distributing, and searching of clinical laboratory procedures from a central repository, decreasing procedure maintenance effort and increasing the utility of procedure information. A standard electronic procedure format could also allow laboratories and vendors to share procedures and procedure layouts, minimizing duplicative word processor editing. Our results suggest that laboratory-specific markup such as CLP-ML will provide greater benefit for such systems than generic markup.

  11. Results of initial analyses of the salt (macro) batch 9 tank 21H qualification samples

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.

    2015-10-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 9 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 9 composite sample indicates that the material does not display any unusual characteristics or observations, such as floating solids, the presence of large amount of solids, or unusual colors. Further results on the chemistry and other tests willmore » be issued in the future.« less

  12. Noble gas isotopes in mineral springs within the Cascadia Forearc, Wasihington and Oregon

    USGS Publications Warehouse

    McCrory, Patricia A.; Constantz, James E.; Hunt, Andrew G.

    2014-01-01

    This U.S. Geological Survey report presents laboratory analyses along with field notes for a pilot study to document the relative abundance of noble gases in mineral springs within the Cascadia forearc of Washington and Oregon. Estimates of the depth to the underlying Juan de Fuca oceanic plate beneath the sample sites are derived from the McCrory and others (2012) slab model. Some of these springs have been previously sampled for chemical analyses (Mariner and others, 2006), but none currently have publicly available noble gas data. Helium isotope values as well as the noble gas values and ratios presented below will be used to determine the sources and mixing history of these mineral waters.

  13. Machinery safety of lathe machine using SHARP-systemic human action reliability procedure: a pilot case study in academic laboratory

    NASA Astrophysics Data System (ADS)

    Suryoputro, M. R.; Sari, A. D.; Sugarindra, M.; Arifin, R.

    2017-12-01

    This research aimed to understand the human reliability analysis, to find the SHARP method with its functionality on case study and also emphasize the practice in Lathe machine, continued with identifying improvement that could be made to the existing safety system. SHARP comprises of 7 stages including definition, screening, breakdown, representation, impact assessment, quantification and documentation. These steps were combined and analysed using HIRA, FTA and FMEA. HIRA analysed the lathe at academic laboratory showed the level of the highest risk with a score of 9 for the activities of power transmission parts and a score of 6 for activities which shall mean the moving parts required to take action to reduce the level of risk. Hence, the highest RPN values obtained in the power transmission activities with a value of 18 in the power transmission and then the activities of moving parts is 12 and the activities of the operating point of 8. Thus, this activity has the highest risk of workplace accidents in the operation. On the academic laboratory the improvement made on the engineering control initially with a machine guarding and completed with necessary administrative controls (SOP, work permit, training and routine cleaning) and dedicated PPEs.

  14. Development of a prediction model on the acceptance of electronic laboratory notebooks in academic environments.

    PubMed

    Kloeckner, Frederik; Farkas, Robert; Franken, Tobias; Schmitz-Rode, Thomas

    2014-04-01

    Documentation of research data plays a key role in the biomedical engineering innovation processes. It makes an important contribution to the protection of intellectual property, the traceability of results and fulfilling the regulatory requirement. Because of the increasing digitalization in laboratories, an electronic alternative to the commonly-used paper-bound notebooks could contribute to the production of sophisticated documentation. However, compared to in an industrial environment, the use of electronic laboratory notebooks is not widespread in academic laboratories. Little is known about the acceptance of an electronic documentation system and the underlying reasons for this. Thus, this paper aims to establish a prediction model on the potential preference and acceptance of scientists either for paper-based or electronic documentation. The underlying data for the analysis originate from an online survey of 101 scientists in industrial, academic and clinical environments. Various parameters were analyzed to identify crucial factors for the system preference using binary logistic regression. The analysis showed significant dependency between the documentation system preference and the supposed workload associated with the documentation system (p<0.006; odds ratio=58.543) and an additional personal component. Because of the dependency of system choice on specific parameters it is possible to predict the acceptance of an electronic laboratory notebook before implementation.

  15. 49 CFR 40.109 - What documentation must the laboratory keep, and for how long?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What documentation must the laboratory keep, and for how long? 40.109 Section 40.109 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.109...

  16. 49 CFR 40.109 - What documentation must the laboratory keep, and for how long?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false What documentation must the laboratory keep, and for how long? 40.109 Section 40.109 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.109...

  17. 49 CFR 40.109 - What documentation must the laboratory keep, and for how long?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false What documentation must the laboratory keep, and for how long? 40.109 Section 40.109 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.109...

  18. 49 CFR 40.109 - What documentation must the laboratory keep, and for how long?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What documentation must the laboratory keep, and for how long? 40.109 Section 40.109 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.109...

  19. 49 CFR 40.109 - What documentation must the laboratory keep, and for how long?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false What documentation must the laboratory keep, and for how long? 40.109 Section 40.109 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.109...

  20. The AMINO experiment: exposure of amino acids in the EXPOSE-R experiment on the International Space Station and in laboratory

    NASA Astrophysics Data System (ADS)

    Bertrand, Marylène; Chabin, Annie; Colas, Cyril; Cadène, Martine; Chaput, Didier; Brack, Andre; Cottin, Herve

    2015-01-01

    In order to confirm the results of previous experiments concerning the chemical behaviour of organic molecules in the space environment, organic molecules (amino acids and a dipeptide) in pure form and embedded in meteorite powder were exposed in the AMINO experiment in the EXPOSE-R facility onboard the International Space Station. After exposure to space conditions for 24 months (2843 h of irradiation), the samples were returned to the Earth and analysed in the laboratory for reactions caused by solar ultraviolet (UV) and other electromagnetic radiation. Laboratory UV exposure was carried out in parallel in the Cologne DLR Center (Deutsches Zentrum für Luft und Raumfahrt). The molecules were extracted from the sample holder and then (1) derivatized by silylation and analysed by gas chromatography coupled to a mass spectrometer (GC-MS) in order to quantify the rate of degradation of the compounds and (2) analysed by high-resolution mass spectrometry (HRMS) in order to understand the chemical reactions that occurred. The GC-MS results confirm that resistance to irradiation is a function of the chemical nature of the exposed molecules and of the wavelengths of the UV light. They also confirm the protective effect of a coating of meteorite powder. The most altered compounds were the dipeptides and aspartic acid while the most robust were compounds with a hydrocarbon chain. The MS analyses document the products of reactions, such as decarboxylation and decarbonylation of aspartic acid, taking place after UV exposure. Given the universality of chemistry in space, our results have a broader implication for the fate of organic molecules that seeded the planets as soon as they became habitable as well as for the effects of UV radiation on exposed molecules at the surface of Mars, for example.

  1. Neutronics Analyses of the Minimum Original HEU TREAT Core

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kontogeorgakos, D.; Connaway, H.; Yesilyurt, G.

    2014-04-01

    This work was performed to support the feasibility study on the potential conversion of the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory from the use of high-enriched uranium (HEU) fuel to the use of low-enriched uranium (LEU) fuel. The analyses were performed by the GTRI Reactor Conversion staff at the Argonne National Laboratory (ANL). The objective of this study was to validate the MCNP model of the TREAT reactor with the well-documented measurements which were taken during the start-up and early operation of TREAT. Furthermore, the effect of carbon graphitization was also addressed. The graphitization level was assumedmore » to be 100% (ANL/GTRI/TM-13/4). For this purpose, a set of experiments was chosen to validate the TREAT MCNP model, involving the approach to criticality procedure, in-core neutron flux measurements with foils, and isothermal temperature coefficient and temperature distribution measurements. The results of this study extended the knowledge base for the TREAT MCNP calculations and established the credibility of the MCNP model to be used in the core conversion feasibility analysis.« less

  2. Quality assurance and quality control for thermal/optical analysis of aerosol samples for organic and elemental carbon.

    PubMed

    Chow, Judith C; Watson, John G; Robles, Jerome; Wang, Xiaoliang; Chen, L-W Antony; Trimble, Dana L; Kohl, Steven D; Tropp, Richard J; Fung, Kochy K

    2011-12-01

    Accurate, precise, and valid organic and elemental carbon (OC and EC, respectively) measurements require more effort than the routine analysis of ambient aerosol and source samples. This paper documents the quality assurance (QA) and quality control (QC) procedures that should be implemented to ensure consistency of OC and EC measurements. Prior to field sampling, the appropriate filter substrate must be selected and tested for sampling effectiveness. Unexposed filters are pre-fired to remove contaminants and acceptance tested. After sampling, filters must be stored in the laboratory in clean, labeled containers under refrigeration (<4 °C) to minimize loss of semi-volatile OC. QA activities include participation in laboratory accreditation programs, external system audits, and interlaboratory comparisons. For thermal/optical carbon analyses, periodic QC tests include calibration of the flame ionization detector with different types of carbon standards, thermogram inspection, replicate analyses, quantification of trace oxygen concentrations (<100 ppmv) in the helium atmosphere, and calibration of the sample temperature sensor. These established QA/QC procedures are applicable to aerosol sampling and analysis for carbon and other chemical components.

  3. Constructing New Expertise: Private and Public Initiatives for Safe Food (Brussels in the First Half of the Nineteenth Century)

    PubMed Central

    Scholliers, Peter

    2014-01-01

    In 1856, the mayor of Brussels proposed the establishment of a municipal laboratory with a chemist to analyse food and beverages to restrain fraud. His proposal was accepted and a laboratory – possibly one of the first municipal laboratories in Europe – was set up. The laboratory still exists today. This paper aims at tracing the conditions in which it emerged, situating it within the laissez-faire context of the time. It was brought into existence by a liberal administration, in a period of little interventionism replete with unencumbered private interests (those of bakers, butchers, grocers, millers, pharmacists, doctors and so on). What will be considered here is the general mood with regard to food fraud, fair trade, correct price, and the quality of food in the first half of the nineteenth century. On a broader level, this contribution addresses the frictions between private and public initiative, while focusing on the process of construction of expertise. The paper makes use of contemporary documents such as reviews, newspapers, association reports and city council chronicles. PMID:25284894

  4. Constructing new expertise: private and public initiatives for safe food (Brussels in the first half of the nineteenth century).

    PubMed

    Scholliers, Peter

    2014-10-01

    In 1856, the mayor of Brussels proposed the establishment of a municipal laboratory with a chemist to analyse food and beverages to restrain fraud. His proposal was accepted and a laboratory - possibly one of the first municipal laboratories in Europe - was set up. The laboratory still exists today. This paper aims at tracing the conditions in which it emerged, situating it within the laissez-faire context of the time. It was brought into existence by a liberal administration, in a period of little interventionism replete with unencumbered private interests (those of bakers, butchers, grocers, millers, pharmacists, doctors and so on). What will be considered here is the general mood with regard to food fraud, fair trade, correct price, and the quality of food in the first half of the nineteenth century. On a broader level, this contribution addresses the frictions between private and public initiative, while focusing on the process of construction of expertise. The paper makes use of contemporary documents such as reviews, newspapers, association reports and city council chronicles.

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brunett, A. J.; Fei, T.; Strons, P. S.

    The Transient Reactor Test Facility (TREAT), located at Idaho National Laboratory (INL), is a test facility designed to evaluate the performance of reactor fuels and materials under transient accident conditions. The facility, an air-cooled, graphite-moderated reactor designed to utilize fuel containing high-enriched uranium (HEU), has been in non-operational standby status since 1994. Currently, in support of the missions of the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Material Management and Minimization (M3) Reactor Conversion Program, a new core design is being developed for TREAT that will utilize low-enriched uranium (LEU). The primary objective of this conversion effort ismore » to design an LEU core that is capable of meeting the performance characteristics of the existing HEU core. Minimal, if any, changes are anticipated for the supporting systems (e.g. reactor trip system, filtration/cooling system, etc.); therefore, the LEU core must also be able to function with the existing supporting systems, and must also satisfy acceptable safety limits. In support of the LEU conversion effort, a range of ancillary safety analyses are required to evaluate the LEU core operation relative to that of the existing facility. These analyses cover neutronics, shielding, and thermal hydraulic topics that have been identified as having the potential to have reduced safety margins due to conversion to LEU fuel, or are required to support the required safety analyses documentation. The majority of these ancillary tasks have been identified in [1] and [2]. The purpose of this report is to document the ancillary safety analyses that have been performed at Argonne National Laboratory during the early stages of the LEU design effort, and to describe ongoing and anticipated analyses. For all analyses presented in this report, methodologies are utilized that are consistent with, or improved from, those used in analyses for the HEU Final Safety Analysis Report (FSAR) [3]. Depending on the availability of historical data derived from HEU TREAT operation, results calculated for the LEU core are compared to measurements obtained from HEU TREAT operation. While all analyses in this report are largely considered complete and have been reviewed for technical content, it is important to note that all topics will be revisited once the LEU design approaches its final stages of maturity. For most safety significant issues, it is expected that the analyses presented here will be bounding, but additional calculations will be performed as necessary to support safety analyses and safety documentation. It should also be noted that these analyses were completed as the LEU design evolved, and therefore utilized different LEU reference designs. Preliminary shielding, neutronic, and thermal hydraulic analyses have been completed and have generally demonstrated that the various LEU core designs will satisfy existing safety limits and standards also satisfied by the existing HEU core. These analyses include the assessment of the dose rate in the hodoscope room, near a loaded fuel transfer cask, above the fuel storage area, and near the HEPA filters. The potential change in the concentration of tramp uranium and change in neutron flux reaching instrumentation has also been assessed. Safety-significant thermal hydraulic items addressed in this report include thermally-induced mechanical distortion of the grid plate, and heating in the radial reflector.« less

  6. Creating and Evaluating a Hypertext System of Documenting Analytical Test Methods in a Chemical Plant Quality Assurance Laboratory.

    ERIC Educational Resources Information Center

    White, Charles E., Jr.

    The purpose of this study was to develop and implement a hypertext documentation system in an industrial laboratory and to evaluate its usefulness by participative observation and a questionnaire. Existing word-processing test method documentation was converted directly into a hypertext format or "hyperdocument." The hyperdocument was designed and…

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carlsbad Field Office

    The Performance Demonstration Program (PDP) for headspace gases distributes blind audit samples in a gas matrix for analysis of volatile organic compounds (VOCs). Participating measurement facilities (i.e., fixed laboratories, mobile analysis systems, and on-line analytical systems) are located across the United States. Each sample distribution is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD) (DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardousmore » Waste Facility Permit (NM4890139088-TSDF) issued by the New Mexico Environment Department (NMED). The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the Headspace Gas (HSG) PDP. Participating measurement facilities analyze blind audit samples of simulated TRU waste package headspace gases according to the criteria set by this PDP Plan. Blind audit samples (hereafter referred to as PDP samples) are used as an independent means to assess each measurement facility’s compliance with the WAP quality assurance objectives (QAOs). To the extent possible, the concentrations of VOC analytes in the PDP samples encompass the range of concentrations anticipated in actual TRU waste package headspace gas samples. Analyses of headspace gases are required by the WIPP to demonstrate compliance with regulatory requirements. These analyses must be performed by measurement facilities that have demonstrated acceptable performance in this PDP. These analyses are referred to as WIPP analyses and the TRU waste package headspace gas samples on which they are performed are referred to as WIPP samples in this document. Participating measurement facilities must analyze PDP samples using the same procedures used for routine waste characterization analyses of WIPP samples.« less

  8. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carlsbad Field Office

    The Performance Demonstration Program (PDP) for headspace gases distributes sample gases of volatile organic compounds (VOCs) for analysis. Participating measurement facilities (i.e., fixed laboratories, mobile analysis systems, and on-line analytical systems) are located across the United States. Each sample distribution is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD) (DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardous Waste Facility Permit (NM4890139088-TSDF) issuedmore » by the New Mexico Environment Department (NMED). The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the Headspace Gas (HSG) PDP. Participating measurement facilities analyze blind audit samples of simulated TRU waste package headspace gases according to the criteria set by this PDP Plan. Blind audit samples (hereafter referred to as PDP samples) are used as an independent means to assess each measurement facility’s compliance with the WAP quality assurance objectives (QAOs). To the extent possible, the concentrations of VOC analytes in the PDP samples encompass the range of concentrations anticipated in actual TRU waste package headspace gas samples. Analyses of headspace gases are required by the WIPP to demonstrate compliance with regulatory requirements. These analyses must be performed by measurement facilities that have demonstrated acceptable performance in this PDP. These analyses are referred to as WIPP analyses and the TRU waste package headspace gas samples on which they are performed are referred to as WIPP samples in this document. Participating measurement facilities must analyze PDP samples using the same procedures used for routine waste characterization analyses of WIPP samples.« less

  9. Affirmative Action Plans, January 1, 1994--December 31, 1994. Revision

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-02-16

    This document is the Affirmative Action Plan for January 1, 1994 through December 31, 1994 for the Lawrence Berkeley Laboratory, University of California (``LBL`` or ``the Laboratory.``) This is an official document that will be presented upon request to the Office of Federal Contract Compliance Programs, US Department of Labor. The plan is prepared in accordance with the Executive Order 11246 and 41 CFR Section 60-1 et seq. covering equal employment opportunity and will be updated during the year, if appropriate. Analyses included in this volume as required by government regulations are based on statistical comparisons. All statistical comparisons involvemore » the use of geographic areas and various sources of statistics. The geographic areas and sources of statistics used here are in compliance with the government regulations, as interpreted. The use of any geographic area or statistic does not indicate agreement that the geographic area is the most appropriate or that the statistic is the most relevant. The use of such geographic areas and statistics is intended to have no significance outside the context of this Affirmative Action Plan, although, of course, such statistics and geographic areas will be used in good faith with respect to this Affirmative Action Plan.« less

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Campbell, J.A.; Clauss, S.A.; Grant, K.E.

    The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work.

  11. In-Tank Processing (ITP) Geotechnical Summary Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cumbest, R.J.

    A geotechnical investigation has been completed for the In Tank Processing Facility (ITP) which consists of buildings 241-96H and 241-32H; and Tanks 241-948H, 241-949H, 241-950H, and 241-951H. The investigation consisted of a literature search for relevant technical data, field explorations, field and laboratory testing, and analyses. This document presents a summary of the scope and results to date of the investigations and engineering analyses for these facilities. A final geotechnical report, which will include a more detailed discussion and all associated boring logs, laboratory test results, and analyses will be issued in October 1994.The purpose of the investigation is tomore » obtain geotechnical information to evaluate the seismic performance of the foundation materials and embankme nts under and around the ITP. The geotechnical engineering objectives of the investigation are to: 1) define the subsurface stratigraphy, 2) obtain representative engineering properties of the subsurface materials, 3) assess the competence of the subsurface materials under static and dynamic loads, 4) derive properties for seismic soil-structure interaction analysis, 5) evaluate the areal and vertical extent of horizons that might cause dynamic settlement or instability, and 6) determine settlement at the foundation level of the tanks.« less

  12. Summary of flat-plate solar array project documentation: Abstracts of published documents, 1975-1986, revision 1

    NASA Technical Reports Server (NTRS)

    Phillips, M. J.

    1986-01-01

    Abstracts of final reports, or the latest quarterly or annual, of the Flat-Plate Solar Array (FSA) Project Contractor of Jet Propulsion Laboratory (JPL) in-house activities are presented. Also presented is a list of proceedings and publications, by author, of work connected with the project. The aim of the program has been to stimulate the development of technology that will enable the private sector to manufacture and widely use photovoltaic systems for the generation of electricity in residential, commercial, industrial, and Government applications at a cost per watt that is competitive with utility generated power. FSA Project activities have included the sponsoring of research and development efforts in silicon refinement processes, advanced silicon sheet growth techniques, higher efficiency solar cells, solar cell/module fabrication processes, encapsulation, module/array engineering and reliability, and economic analyses.

  13. Geothermal NEPA Database on OpenEI (Poster)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Young, K. R.; Levine, A.

    2014-09-01

    The National Renewable Energy Laboratory (NREL) developed the Geothermal National Environmental Policy Act (NEPA) Database as a platform for government agencies and industry to access and maintain information related to geothermal NEPA documents. The data were collected to inform analyses of NEPA timelines, and the collected data were made publically available via this tool in case others might find the data useful. NREL staff and contractors collected documents from agency websites, during visits to the two busiest Bureau of Land Management (BLM) field offices for geothermal development, and through email and phone call requests from other BLM field offices. Theymore » then entered the information into the database, hosted by Open Energy Information (http://en.openei.org/wiki/RAPID/NEPA). The long-term success of the project will depend on the willingness of federal agencies, industry, and others to populate the database with NEPA and related documents, and to use the data for their own analyses. As the information and capabilities of the database expand, developers and agencies can save time on new NEPA reports by accessing a single location to research related activities, their potential impacts, and previously proposed and imposed mitigation measures. NREL used a wiki platform to allow industry and agencies to maintain the content in the future so that it continues to provide relevant and accurate information to users.« less

  14. Assessment Report Sandia National Laboratories Fuel Cycle Technologies Quality Assurance Evaluation of FY15 SNL FCT M2 Milestone Deliverables

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Appel, Gordon John

    Sandia National Laboratories (SNL) Fuel Cycle Technologies (FCT) program activities are conducted in accordance with FCT Quality Assurance Program Document (FCT-QAPD) requirements. The FCT-QAPD interfaces with SNL approved Quality Assurance Program Description (SNL-QAPD) as explained in the Sandia National Laboratories QA Program Interface Document for FCT Activities (Interface Document). This plan describes SNL's FY16 assessment of SNL's FY15 FCT M2 milestone deliverable's compliance with program QA requirements, including SNL R&A requirements. The assessment is intended to confirm that SNL's FY15 milestone deliverables contain the appropriate authenticated review documentation and that there is a copy marked with SNL R&A numbers.

  15. ERLN Radiation Focus Area

    EPA Pesticide Factsheets

    As part of the Environmental Response Laboratory Network, the National Air and Radiation Environmental Laboratory (NAREL) here provides your laboratory with access to radiation-specific laboratory guidance documents and training courses.

  16. Research: increasing value, reducing waste 2

    PubMed Central

    Ioannidis, John P A; Greenland, Sander; Hlatky, Mark A; Khoury, Muin J; Macleod, Malcolm R; Moher, David; Schulz, Kenneth F; Tibshirani, Robert

    2015-01-01

    Correctable weaknesses in the design, conduct, and analysis of biomedical and public health research studies can produce misleading results and waste valuable resources. Small effects can be difficult to distinguish from bias introduced by study design and analyses. An absence of detailed written protocols and poor documentation of research is common. Information obtained might not be useful or important, and statistical precision or power is often too low or used in a misleading way. Insufficient consideration might be given to both previous and continuing studies. Arbitrary choice of analyses and an overemphasis on random extremes might affect the reported findings. Several problems relate to the research workforce, including failure to involve experienced statisticians and methodologists, failure to train clinical researchers and laboratory scientists in research methods and design, and the involvement of stakeholders with conflicts of interest. Inadequate emphasis is placed on recording of research decisions and on reproducibility of research. Finally, reward systems incentivise quantity more than quality, and novelty more than reliability. We propose potential solutions for these problems, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems. PMID:24411645

  17. Experiments with the Dragon Machine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    R.E. Malenfant

    2005-08-12

    The basic characteristics of a self-sustaining chain reaction were demonstrated with the Chicago Pile in 1943, but it was not until early 1945 that sufficient enriched material became available to experimentally verify fast-neutron cross-sections and the kinetic characteristics of a nuclear chain reaction sustained with prompt neutrons alone. However, the demands of wartime and the rapid decline in effort following the cessation of hostilities often resulted in the failure to fully document the experiments or in the loss of documentation as personnel returned to civilian pursuits. When documented, the results were often highly classified. Even when eventually declassified, the datamore » were often not approved for public release until years later.2 Even after declassification and approval for public release, the records are sometimes difficult to find. Through a fortuitous discovery, a set of handwritten notes by ''ORF July 1945'' entitled ''Dragon - Research with a Pulsed Fission Reactor'' was found by William L. Myers in an old storage safe at Pajarito Site of the Los Alamos National Laboratory3. Of course, ORF was identified as Otto R. Frisch. The document was attached to a page in a nondescript spiral bound notebook labeled ''494 Book'' that bore the signatures of Louis Slotin and P. Morrison. The notes also reference an ''Idea LS'' that can only be Louis Slotin. The discovery of the notes led to a search of Laboratory Archives, the negative files of the photo lab, and the Report Library for additional details of the experiments with the Dragon machine that were conducted between January and July 1945. The assembly machine and the experiments were carefully conceived and skillfully executed. The analyses--without the crutch of computers--display real insight into the characteristics of the nuclear chain reaction. The information presented here provides what is believed to be a complete collection of the original documentation of the observations made with the Dragon Machine in early 1945.« less

  18. The effect of a Lean quality improvement implementation program on surgical pathology specimen accessioning and gross preparation error frequency.

    PubMed

    Smith, Maxwell L; Wilkerson, Trent; Grzybicki, Dana M; Raab, Stephen S

    2012-09-01

    Few reports have documented the effectiveness of Lean quality improvement in changing anatomic pathology patient safety. We used Lean methods of education; hoshin kanri goal setting and culture change; kaizen events; observation of work activities, hand-offs, and pathways; A3-problem solving, metric development, and measurement; and frontline work redesign in the accessioning and gross examination areas of an anatomic pathology laboratory. We compared the pre- and post-Lean implementation proportion of near-miss events and changes made in specific work processes. In the implementation phase, we documented 29 individual A3-root cause analyses. The pre- and postimplementation proportions of process- and operator-dependent near-miss events were 5.5 and 1.8 (P < .002) and 0.6 and 0.6, respectively. We conclude that through culture change and implementation of specific work process changes, Lean implementation may improve pathology patient safety.

  19. Students' motivation toward laboratory work in physiology teaching.

    PubMed

    Dohn, Niels Bonderup; Fago, Angela; Overgaard, Johannes; Madsen, Peter Teglberg; Malte, Hans

    2016-09-01

    The laboratory has been given a central role in physiology education, and teachers report that it is motivating for students to undertake experimental work on live animals or measuring physiological responses on the students themselves. Since motivation is a critical variable for academic learning and achievement, then we must concern ourselves with questions that examine how students engage in laboratory work and persist at such activities. The purpose of the present study was to investigate how laboratory work influences student motivation in physiology. We administered the Lab Motivation Scale to assess our students' levels of interest, willingness to engage (effort), and confidence in understanding (self-efficacy). We also asked students about the role of laboratory work for their own learning and their experience in the physiology laboratory. Our results documented high levels of interest, effort, and self-efficacy among the students. Correlation analyses were performed on the three motivation scales and exam results, yet a significant correlation was only found between self-efficacy in laboratory work and academic performance at the final exam. However, almost all students reported that laboratory work was very important for learning difficult concepts and physiological processes (e.g., action potential), as the hands-on experiences gave a more concrete idea of the learning content and made the content easier to remember. These results have implications for classroom practice as biology students find laboratory exercises highly motivating, despite their different personal interests and subject preferences. This highlights the importance of not replacing laboratory work by other nonpractical approaches, for example, video demonstrations or computer simulations. Copyright © 2016 The American Physiological Society.

  20. Use of a Rapid Ethylene Glycol Assay: a 4-Year Retrospective Study at an Academic Medical Center.

    PubMed

    Rooney, Sydney L; Ehlers, Alexandra; Morris, Cory; Drees, Denny; Davis, Scott R; Kulhavy, Jeff; Krasowski, Matthew D

    2016-06-01

    Ethylene glycol (EG) is a common cause of toxic ingestions. Gas chromatography (GC)-based laboratory assays are the gold standard for diagnosing EG intoxication. However, GC requires specialized instrumentation and technical expertise that limits feasibility for many clinical laboratories. The objective of this retrospective study was to determine the utility of incorporating a rapid EG assay for management of cases with suspected EG poisoning. The University of Iowa Hospitals and Clinics core clinical laboratory adapted a veterinary EG assay (Catachem, Inc.) for the Roche Diagnostics cobas 8000 c502 analyzer and incorporated this assay in an osmolal gap-based algorithm for potential toxic alcohol/glycol ingestions. The main limitation is that high concentrations of propylene glycol (PG), while readily identifiable by reaction rate kinetics, can interfere with EG measurement. The clinical laboratory had the ability to perform GC for EG and PG, if needed. A total of 222 rapid EG and 24 EG/PG GC analyses were documented in 106 patient encounters. Of ten confirmed EG ingestions, eight cases were managed entirely with the rapid EG assay. PG interference was evident in 25 samples, leading to 8 GC analyses to rule out the presence of EG. Chart review of cases with negative rapid EG assay results showed no evidence of false negatives. The results of this study highlight the use of incorporating a rapid EG assay for the diagnosis and management of suspected EG toxicity by decreasing the reliance on GC. Future improvements would involve rapid EG assays that completely avoid interference by PG.

  1. Using the U.S. Geological Survey National Water Quality Laboratory LT-MDL to Evaluate and Analyze Data

    USGS Publications Warehouse

    Bonn, Bernadine A.

    2008-01-01

    A long-term method detection level (LT-MDL) and laboratory reporting level (LRL) are used by the U.S. Geological Survey?s National Water Quality Laboratory (NWQL) when reporting results from most chemical analyses of water samples. Changing to this method provided data users with additional information about their data and often resulted in more reported values in the low concentration range. Before this method was implemented, many of these values would have been censored. The use of the LT-MDL and LRL presents some challenges for the data user. Interpreting data in the low concentration range increases the need for adequate quality assurance because even small contamination or recovery problems can be relatively large compared to concentrations near the LT-MDL and LRL. In addition, the definition of the LT-MDL, as well as the inclusion of low values, can result in complex data sets with multiple censoring levels and reported values that are less than a censoring level. Improper interpretation or statistical manipulation of low-range results in these data sets can result in bias and incorrect conclusions. This document is designed to help data users use and interpret data reported with the LTMDL/ LRL method. The calculation and application of the LT-MDL and LRL are described. This document shows how to extract statistical information from the LT-MDL and LRL and how to use that information in USGS investigations, such as assessing the quality of field data, interpreting field data, and planning data collection for new projects. A set of 19 detailed examples are included in this document to help data users think about their data and properly interpret lowrange data without introducing bias. Although this document is not meant to be a comprehensive resource of statistical methods, several useful methods of analyzing censored data are demonstrated, including Regression on Order Statistics and Kaplan-Meier Estimation. These two statistical methods handle complex censored data sets without resorting to substitution, thereby avoiding a common source of bias and inaccuracy.

  2. Performance Audit of the U.S. Geological Survey, Energy Resource Program Inorganic Geochemistry Laboratory

    USGS Publications Warehouse

    Luppens, James A.; Janke, Louis G.; McCord, Jamey D.; Bullock, John H.; Brazeau, Lisa; Affronter, Ronald H.

    2007-01-01

    A performance audit of the U.S. Geological Survey (USGS), Energy Resource Program (ERP) Inorganic Geochemistry Laboratory (IGL) was conducted between August, 2003 and October, 2005. The goals were to ensure that a high level of analytical performance was maintained and identify any areas that could be enhanced. The audit was subdivided into three phases. Phase 1 was a preliminary assessment of current performance based on recent performance on CANSPEX samples. IGL performance was also compared to laboratories world-wide with similar scope. Phase 2 consisted of the implementation of the recommended changes made in Phase 1. Phase 3 of the audit consisted of a reassessment effort to evaluate the effectiveness of the recommendations made in the Phase 1 and an on-site audit of the laboratory facilities. Phases 1 and 3 required summary reports that are included in Appendices A and B of this report. The audit found that the IGL was one of the top two laboratories compared for trace element analyses. Several recommendations to enhance performance on major and minor elemental parameters were made and implemented. Demonstrated performance improvements as a result of the recommended changes were documented. Several initiatives to sustain the performance improvements gained from the audit have been implemented.

  3. Analysis of Data in Accordance with Space Flight Mission Environmental Requirements

    NASA Technical Reports Server (NTRS)

    Shei, Monica

    2011-01-01

    The Environmental Assurance Program sets forth standards to ensure that all flight hardware is compatible with the environments that will be encountered during a spacecraft mission. It outlines the design, test and analysis, and risk control standards for the mission and certifies that it will survive in any external or self-induced environments that the spacecraft may experience. The Environmental Requirements Document (ERD) is the most important document in the Environmental Assurance Program, providing the design and test requirements for the project's flight system, subsystems, assemblies, and instruments. This summer's project was to assist Environmental Requirements Engineers (ERE's) in completing the Environmental Assurance Program Summary Report for both the Juno Project and Mars Science Laboratory (MSL) Project. The Summary Report is a document summarizing the environmental tests and analyses of each spacecraft at both the assembly and system level. It compiles a source of all relevant information such as waivers and Problem/Failure Reports (PFRs) into a single report for easy reference of how well the spacecraft met the requirements of the project.

  4. Conservation and Renewable Energy Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vaughan, K.H.

    1991-05-01

    This bibliography lists reports and selected papers published under the Oak Ridge National Laboratory Conservation and Renewable Energy Program from 1986 through February 1991. Information on documents published prior to 1986 can be obtained from ORNL. Most of the documents in the bibliography are available from Oak Ridge National Laboratory.

  5. Environmental resource document for the Idaho National Engineering Laboratory. Volume 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Irving, J.S.

    This document contains information related to the environmental characterization of the Idaho National Engineering Laboratory (INEL). The INEL is a major US Department of Energy facility in southeastern Idaho dedicated to nuclear research, waste management, environmental restoration, and other activities related to the development of technology. Environmental information covered in this document includes land, air, water, and ecological resources; socioeconomic characteristics and land use; and cultural, aesthetic, and scenic resources.

  6. Properties and Units in the Clinical Laboratory Sciences. IX. Properties and Units in Trace Elements (IUPAC-IFCC Technical report 1997). International Union of Pure and Applied Chemistry and International Federation of Clinical Chemistry. rita.cornelis@rug.ac.be.

    PubMed

    Cornelis, R; Fuentes-Arderiu, X; Bruunshuus, I; Templeton, D

    1997-12-10

    This document is the first recommendation on the presentation of trace elements and their values in clinical laboratory sciences from IFCC and IUPAC. It forms part of the ongoing effort to standardize requests and reporting of laboratory data for transmission across cultural and linguistic domains, without attempting to standardize the language used by clinicians and laboratory practitioners. Subsequent documents deal with syntax, kinds-of-property, and properties and units used in other areas of clinical laboratory sciences.

  7. DATA QUALITY OBJECTIVES FOR SELECTING WASTE SAMPLES FOR THE BENCH STEAM REFORMER TEST

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    BANNING DL

    2010-08-03

    This document describes the data quality objectives to select archived samples located at the 222-S Laboratory for Fluid Bed Steam Reformer testing. The type, quantity and quality of the data required to select the samples for Fluid Bed Steam Reformer testing are discussed. In order to maximize the efficiency and minimize the time to treat Hanford tank waste in the Waste Treatment and Immobilization Plant, additional treatment processes may be required. One of the potential treatment processes is the fluid bed steam reformer (FBSR). A determination of the adequacy of the FBSR process to treat Hanford tank waste is required.more » The initial step in determining the adequacy of the FBSR process is to select archived waste samples from the 222-S Laboratory that will be used to test the FBSR process. Analyses of the selected samples will be required to confirm the samples meet the testing criteria.« less

  8. Illinois Occupational Skill Standards: Clinical Laboratory Science/Biotechnology Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended to serve as a guide for workforce preparation program providers, details the Illinois Occupational Skill Standards for clinical laboratory occupations programs. The document begins with a brief overview of the Illinois perspective on occupational skill standards and credentialing, the process used to develop the…

  9. \\tLaboratory Environmental Sample Disposal Information Document - Companion to Standardized Analytical Methods for Environmental Restoration Following Homeland Security Events (SAM) – Revision 5.0

    EPA Pesticide Factsheets

    Document is intended to provide general guidelines for use byEPA and EPA-contracted laboratories when disposing of samples and associated analytical waste following use of the analytical methods listed in SAM.

  10. In situ treatment of VOCs by recirculation technologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siegrist, R.L.; Webb, O.F.; Ally, M.R.

    1993-06-01

    The project described herein was conducted by Oak Ridge National Laboratory (ORNL) to identify processes and technologies developed in Germany that appeared to have near-term potential for enhancing the cleanup of volatile organic compound (VOC) contaminated soil and groundwater at DOE sites. Members of the ORNL research team identified and evaluated selected German technologies developed at or in association with the University of Karlsruhe (UoK) for in situ treatment of VOC contaminated soils and groundwater. Project activities included contacts with researchers within three departments of the UoK (i.e., Applied Geology, Hydromechanics, and Soil and Foundation Engineering) during fall 1991 andmore » subsequent visits to UoK and private industry collaborators during February 1992. Subsequent analyses consisted of engineering computations, groundwater flow modeling, and treatment process modeling. As a result of these project efforts, two processes were identified as having near-term potential for DOE: (1) the vacuum vaporizer well/groundwater recirculation well and (2) the porous pipe/horizontal well. This document was prepared to summarize the methods and results of the assessment activities completed during the initial year of the project. The project is still ongoing, so not all facets of the effort are completely described in this document. Recommendations for laboratory and field experiments are provided.« less

  11. A Survey of Equipment in the Singing Voice Studio and Its Perceived Effectiveness by Vocologists and Student Singers.

    PubMed

    Gerhard, Julia; Rosow, David E

    2016-05-01

    Speech-language pathologists have long used technology for the clinical measurement of the speaking voice, but present research shows that vocal pedagogues and voice students are becoming more accepting of technology in the studio. As a result, the equipment and technology used in singing voice studios by speech-language pathologists and vocal pedagogues are changing. Although guides exist regarding equipment and technology necessary for developing a voice laboratory and private voice studio, there are no data documenting the current implementation of these items and their perceived effectiveness. This study seeks to document current trends in equipment used in voice laboratories and studios. Two separate surveys were distributed to 60 vocologists and approximately 300 student singers representative of the general singing student population. The surveys contained questions about the inventory of items found in voice studios and perceived effectiveness of these items. Data were analyzed using descriptive analyses and statistical analyses when applicable. Twenty-six of 60 potential vocologists responded, and 66 student singers responded. The vocologists reported highly uniform inventories and ratings of studio items. There were wide-ranging differences between the inventories reported by the vocologist and student singer groups. Statistically significant differences between ratings of effectiveness of studio items were found for 11 of the 17 items. In all significant cases, vocologists rated usefulness to be higher than student singers. Although the order of rankings of vocologists and student singers was similar, a much higher percentage of vocologists report the items as being efficient and effective than students. The historically typical studio items, including the keyboard and mirror, were ranked as most effective by both vocologists and student singers. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  12. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to meet... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or...

  13. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to meet... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or...

  14. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to meet... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or...

  15. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to meet... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or...

  16. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to meet... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or...

  17. Occupational safety and health status of medical laboratories in Kajiado County, Kenya.

    PubMed

    Tait, Fridah Ntinyari; Mburu, Charles; Gikunju, Joseph

    2018-01-01

    Despite the increasing interest in Occupational Safety and Health (OSH), seldom studies are available on OSH in medical laboratories from developing countries in general although a high number of injuries occur without proper documentation. It is estimated that every day 6,300 people die as a result of occupational accidents or work-related diseases resulting in over 2.3 million deaths per year. Medical laboratories handle a wide range of materials, potentially dangerous pathogenic agents and exposes health workers to numerous potential hazards. This study evaluated the status of OSH in medical laboratories in Kajiado County, Kenya. The objectives included establishment of biological, chemical and physical hazards; reviewing medical laboratories control measures; and enumerating factors hindering implementation of good practices in OSH. This was a cross-sectional descriptive study research design. Observation check lists, interview schedules and structured questionnaires were used. The study was carried out in 108 medical laboratories among 204 sampled respondents. Data was analysed using statistical package for social science (SPSS) 20 software. The commonest type of hazards in medical laboratories include; bacteria (80%) for Biological hazards; handling un-labelled and un-marked chemicals (38.2%) for chemical hazards; and laboratory equipment's dangerously placed (49.5%) for Physical hazards. According to Pearson's Product Moment Correlation analysis, not-wearing personal protective equipment's was statistically associated with exposure to hazards. Individual control measures were statistically significant at 0.01 significance level. Only 65.1% of the factors influencing implementation of OSH in medical laboratories were identified. Training has the highest contribution to good OSH practices.

  18. Detection of Campylobacter in human faecal samples in Fiji.

    PubMed

    Devi, Aruna; Wilkinson, Jenny; Mahony, Timothy; Vanniasinkam, Thiru

    2014-01-01

    Data on campylobacteriosis in developed countries are well documented; in contrast, few studies on campylobacteriosis have been conducted in developing countries. This study was undertaken to test for Campylobacter in human faecal samples sent to the two major pathology laboratories in Fiji. A total of 408 diarrhoeal faecal samples were collected from the two major hospital pathology laboratories in Central Fiji (Suva) and Western Fiji (Lautoka) between December 2012 and February 2013 and from June to July 2013. Samples were analysed for the presence of Campylobacter using polymerase chain reaction (PCR) based methods. Campylobacter was detected in 241/408 (59.1%) of samples tested using PCR. Samples from children aged less than five accounted for 21.6% of positive cases. Campylobacter was detected in 59.1% of diarrhoeal samples collected from the two main laboratories in Fiji. A high proportion of children under five years with Campylobacter has been reported in other countries and could be due to parents being more likely to seek medical attention. Further studies are required to confirm the species of Campylobacter that are predominantly associated with gastroenteritis in Fiji.

  19. Recommendation for the review of biological reference intervals in medical laboratories.

    PubMed

    Henny, Joseph; Vassault, Anne; Boursier, Guilaine; Vukasovic, Ines; Mesko Brguljan, Pika; Lohmander, Maria; Ghita, Irina; Andreu, Francisco A Bernabeu; Kroupis, Christos; Sprongl, Ludek; Thelen, Marc H M; Vanstapel, Florent J L A; Vodnik, Tatjana; Huisman, Willem; Vaubourdolle, Michel

    2016-12-01

    This document is based on the original recommendation of the Expert Panel on the Theory of Reference Values of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), updated guidelines were recently published under the auspices of the IFCC and the Clinical and Laboratory Standards Institute (CLSI). This document summarizes proposals for recommendations on: (i) The terminology, which is often confusing, noticeably concerning the terms of reference limits and decision limits. (ii) The method for the determination of reference limits according to the original procedure and the conditions, which should be used. (iii) A simple procedure allowing the medical laboratories to fulfill the requirements of the regulation and standards. The updated document proposes to verify that published reference limits are applicable to the laboratory involved. Finally, the strengths and limits of the revised recommendations (especially the selection of the reference population, the maintenance of the analytical quality, the choice of the statistical method used…) will be briefly discussed.

  20. School Science Laboratories. A Guide to Some Hazardous Substances. A Supplement to the National Institute for Occupational Safety and Health Manual of Safety and Health Hazards in the School Science Laboratory.

    ERIC Educational Resources Information Center

    Council of State Science Supervisors, Washington, DC.

    The purpose of this document is to identify potentially hazardous substances that may be in use in many school laboratories and to provide an inventory of these substances so that science teachers may take the initiative in providing for the proper storage, handling, use, and if warranted, removal of hazardous materials. The document consists of…

  1. Final Radiological Assessment of External Exposure for CLEAR-Line Americium Recovery Operations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Davis, Adam C.; Belooussova, Olga N.; Hetrick, Lucas Duane

    2014-11-12

    Los Alamos National Laboratory is currently planning to implement an americium recovery program. The americium, ordinarily isotopically pure 241Am, would be extracted from existing Pu materials, converted to an oxide and shipped to support fabrication of americium oxide-beryllium neutron sources. These operations would occur in the currently proposed Chloride Extraction and Actinide Recovery (CLEAR) line of glove boxes. This glove box line would be collocated with the currently-operational Experimental Chloride Extraction Line (EXCEL). The focus of this document is to provide an in-depth assessment of the currently planned radiation protection measures and to determine whether or not further design workmore » is required to satisfy design-goal and ALARA requirements. Further, this document presents a history of americium recovery operations in the Department of Energy and high-level descriptions of the CLEAR line operations to provide a basis of comparison. Under the working assumptions adopted by this study, it was found that the evaluated design appears to mitigate doses to a level that satisfies the ALARA-in-design requirements of 10 CFR 835 as implemented by the Los Alamos National Laboratory procedure P121. The analyses indicate that extremity doses would also meet design requirements. Dose-rate calculations were performed using the radiation transport code MCNP5 and doses were estimated using a time-motion study developed in consort with the subject matter expert. A copy of this report and all supporting documentation are located on the Radiological Engineering server at Y:\\Rad Engineering\\2013 PROJECTS\\TA-55 Clear Line.« less

  2. Sandia National Laboratories/New Mexico Environmental Baseline update--Revision 1.0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-07-01

    This report provides a baseline update to provide the background information necessary for personnel to prepare clear and consise NEPA documentation. The environment of the Sandia National Laboratories is described in this document, including the ecology, meteorology, climatology, seismology, emissions, cultural resources and land use, visual resources, noise pollution, transportation, and socioeconomics.

  3. An Analysis of the Laboratory Assisting Occupation.

    ERIC Educational Resources Information Center

    McGee, Patricia; And Others

    The general purpose of the occupational analysis is to provide workable, basic information dealing with the many and varied duties performed in the laboratory assistant occupation. The document opens with a brief introduction followed by a job description. The bulk of the document is presented in table form. Eleven duties are broken down into a…

  4. Annotated Bibliography of Human Factors Laboratory Reports (1945-1968) Supplement #4, 1979-1983.

    ERIC Educational Resources Information Center

    Naval Training Equipment Center, Orlando, FL. Human Factors Lab.

    A complete bibliographic reference and an abstract are provided for each of 66 publications of the Human Factors Laboratory from 1979 through 1983, including in-house and contractor-developed documents. Documents are indexed by source, author, and subject matter. Publications address such topics as adaptive training, air combat maneuvering,…

  5. Annotated bibliography of Software Engineering Laboratory (SEL) literature

    NASA Technical Reports Server (NTRS)

    Card, D.

    1982-01-01

    An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is presented. More than 75 publications are summarized. An index of these publications by subject is also included. These publications cover many areas of software engineering and range from research reports to software documentation.

  6. ISO/IEC 17025 laboratory accreditation of NRC Acoustical Standards Program

    NASA Astrophysics Data System (ADS)

    Wong, George S. K.; Wu, Lixue; Hanes, Peter; Ohm, Won-Suk

    2004-05-01

    Experience gained during the external accreditation of the Acoustical Standards Program at the Institute for National Measurement Standards of the National Research Council is discussed. Some highlights include the preparation of documents for calibration procedures, control documents with attention to reducing future paper work and the need to maintain documentation or paper trails to satisfy the external assessors. General recommendations will be given for laboratories that are contemplating an external audit in accordance to the requirements of ISO/IEC 17025.

  7. Integration of scanned document management with the anatomic pathology laboratory information system: analysis of benefits.

    PubMed

    Schmidt, Rodney A; Simmons, Kim; Grimm, Erin E; Middlebrooks, Michael; Changchien, Rosy

    2006-11-01

    Electronic document management systems (EDMSs) have the potential to improve the efficiency of anatomic pathology laboratories. We implemented a novel but simple EDMS for scanned documents as part of our laboratory information system (AP-LIS) and collected cost-benefit data with the intention of discerning the value of such a system in general and whether integration with the AP-LIS is advantageous. We found that the direct financial benefits are modest but the indirect and intangible benefits are large. Benefits of time savings and access to data particularly accrued to pathologists and residents (3.8 h/d saved for 26 pathologists and residents). Integrating the scanned document management system (SDMS) into the AP-LIS has major advantages in terms of workflow and overall simplicity. This simple, integrated SDMS is an excellent value in a practice like ours, and many of the benefits likely apply in other practice settings.

  8. 76 FR 19309 - Solicitation of Letters of Interest To Participate in National Environmental Policy Act Pilot...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... environmental analyses and documents required under NEPA to determine the extent to which these approaches improve the quality, timeliness, and cost effectiveness of such analyses and documents. The pilot project will focus only on NEPA analyses and documents associated with petitions for nonregulated status for GE...

  9. List of DOE radioisotope customers with summary of radioisotope shipments FY 1978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burlison, J.S.; Laidler, R.I.

    1979-05-01

    The purpose of the document is to list DOE's radioisotopes production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc.

  10. 42 CFR 493.1239 - Standard: General laboratory systems quality assessment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of general laboratory systems quality assessment reviews with appropriate staff. (c) The laboratory must document all general laboratory systems quality assessment activities. [68 FR 3703, Jan. 24, 2003... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: General laboratory systems quality...

  11. Superfund Contract Laboratory Program

    EPA Pesticide Factsheets

    The Contract Laboratory Program (CLP) is a national network of EPA personnel, commercial laboratories, and support contractors whose primary mission is to provide data of known and documented quality to the Superfund program.

  12. Preliminary Assessment of the Impact on Reactor Vessel dpa Rates Due to Installation of a Proposed Low Enriched Uranium (LEU) Core in the High Flux Isotope Reactor (HFIR)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daily, Charles R.

    2015-10-01

    An assessment of the impact on the High Flux Isotope Reactor (HFIR) reactor vessel (RV) displacements-per-atom (dpa) rates due to operations with the proposed low enriched uranium (LEU) core described by Ilas and Primm has been performed and is presented herein. The analyses documented herein support the conclusion that conversion of HFIR to low-enriched uranium (LEU) core operations using the LEU core design of Ilas and Primm will have no negative impact on HFIR RV dpa rates. Since its inception, HFIR has been operated with highly enriched uranium (HEU) cores. As part of an effort sponsored by the National Nuclearmore » Security Administration (NNSA), conversion to LEU cores is being considered for future HFIR operations. The HFIR LEU configurations analyzed are consistent with the LEU core models used by Ilas and Primm and the HEU balance-of-plant models used by Risner and Blakeman in the latest analyses performed to support the HFIR materials surveillance program. The Risner and Blakeman analyses, as well as the studies documented herein, are the first to apply the hybrid transport methods available in the Automated Variance reduction Generator (ADVANTG) code to HFIR RV dpa rate calculations. These calculations have been performed on the Oak Ridge National Laboratory (ORNL) Institutional Cluster (OIC) with version 1.60 of the Monte Carlo N-Particle 5 (MCNP5) computer code.« less

  13. Electron/proton spectrometer certification documentation analyses

    NASA Technical Reports Server (NTRS)

    Gleeson, P.

    1972-01-01

    A compilation of analyses generated during the development of the electron-proton spectrometer for the Skylab program is presented. The data documents the analyses required by the electron-proton spectrometer verification plan. The verification plan was generated to satisfy the ancillary hardware requirements of the Apollo Applications program. The certification of the spectrometer requires that various tests, inspections, and analyses be documented, approved, and accepted by reliability and quality control personnel of the spectrometer development program.

  14. SCALE: A modular code system for performing Standardized Computer Analyses for Licensing Evaluation. Volume 1, Part 2: Control modules S1--H1; Revision 5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    SCALE--a modular code system for Standardized Computer Analyses Licensing Evaluation--has been developed by Oak Ridge National Laboratory at the request of the US Nuclear Regulatory Commission. The SCALE system utilizes well-established computer codes and methods within standard analysis sequences that (1) allow an input format designed for the occasional user and/or novice, (2) automated the data processing and coupling between modules, and (3) provide accurate and reliable results. System development has been directed at problem-dependent cross-section processing and analysis of criticality safety, shielding, heat transfer, and depletion/decay problems. Since the initial release of SCALE in 1980, the code system hasmore » been heavily used for evaluation of nuclear fuel facility and package designs. This revision documents Version 4.3 of the system.« less

  15. RAM simulation model for SPH/RSV systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schryver, J.C.; Primm, A.H.; Nelson, S.C.

    1995-12-31

    The US Army`s Project Manager, Crusader is sponsoring the development of technologies that apply to the Self-Propelled Howitzer (SPH), formerly the Advanced Field Artillery System (AFAS), and Resupply Vehicle (RSV), formerly the Future Armored Resupply Vehicle (FARV), weapon system. Oak Ridge National Laboratory (ORNL) is currently performing developmental work in support of the SPH/PSV Crusader system. Supportive analyses of reliability, availability, and maintainability (RAM) aspects were also performed for the SPH/RSV effort. During FY 1994 and FY 1995 OPNL conducted a feasibility study to demonstrate the application of simulation modeling for RAM analysis of the Crusader system. Following completion ofmore » the feasibility study, a full-scale RAM simulation model of the Crusader system was developed for both the SPH and PSV. This report provides documentation for the simulation model as well as instructions in the proper execution and utilization of the model for the conduct of RAM analyses.« less

  16. Radioactive Waste Management Complex low-level waste radiological performance assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maheras, S.J.; Rood, A.S.; Magnuson, S.O.

    This report documents the projected radiological dose impacts associated with the disposal of radioactive low-level waste at the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. This radiological performance assessment was conducted to evaluate compliance with applicable radiological criteria of the US Department of Energy and the US Environmental Protection Agency for protection of the public and the environment. The calculations involved modeling the transport of radionuclides from buried waste, to surface soil and subsurface media, and eventually to members of the public via air, groundwater, and food chain pathways. Projections of doses were made for both offsitemore » receptors and individuals inadvertently intruding onto the site after closure. In addition, uncertainty and sensitivity analyses were performed. The results of the analyses indicate compliance with established radiological criteria and provide reasonable assurance that public health and safety will be protected.« less

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steiner, J.L.; Lime, J.F.; Elson, J.S.

    One dimensional TRAC transient calculations of the process inherent ultimate safety (PIUS) advanced reactor design were performed for a pump-trip SCRAM. The TRAC calculations showed that the reactor power response and shutdown were in qualitative agreement with the one-dimensional analyses presented in the PIUS Preliminary Safety Information Document (PSID) submitted by Asea Brown Boveri (ABB) to the US Nuclear Regulatory Commission for preapplication safety review. The PSID analyses were performed with the ABB-developed RIGEL code. The TRAC-calculated phenomena and trends were also similar to those calculated with another one-dimensional PIUS model, the Brookhaven National Laboratory developed PIPA code. A TRACmore » pump-trip SCRAM transient has also been calculated with a TRAC model containing a multi-dimensional representation of the PIUS intemal flow structures and core region. The results obtained using the TRAC fully one-dimensional PIUS model are compared to the RIGEL, PIPA, and TRAC multi-dimensional results.« less

  18. Environmental Response Laboratory Network (ERLN) Laboratory Requirements

    EPA Pesticide Factsheets

    The Environmental Response Laboratory Network requires its member labs follow specified quality systems, sample management, data reporting, and general, in order to ensure consistent analytical data of known and documented quality.

  19. Tank 241-AP-105, cores 208, 209 and 210, analytical results for the final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nuzum, J.L.

    1997-10-24

    This document is the final laboratory report for Tank 241-AP-105. Push mode core segments were removed from Risers 24 and 28 between July 2, 1997, and July 14, 1997. Segments were received and extruded at 222-S Laboratory. Analyses were performed in accordance with Tank 241-AP-105 Push Mode Core Sampling and Analysis Plan (TSAP) (Hu, 1997) and Tank Safety Screening Data Quality Objective (DQO) (Dukelow, et al., 1995). None of the subsamples submitted for total alpha activity (AT), differential scanning calorimetry (DSC) analysis, or total organic carbon (TOC) analysis exceeded the notification limits as stated in TSAP and DQO. The statisticalmore » results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group, and are not considered in this report. Appearance and Sample Handling Two cores, each consisting of four segments, were expected from Tank 241-AP-105. Three cores were sampled, and complete cores were not obtained. TSAP states core samples should be transported to the laboratory within three calendar days from the time each segment is removed from the tank. This requirement was not met for all cores. Attachment 1 illustrates subsamples generated in the laboratory for analysis and identifies their sources. This reference also relates tank farm identification numbers to their corresponding 222-S Laboratory sample numbers.« less

  20. 42 CFR 493.1233 - Standard: Complaint investigations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1233 Standard: Complaint investigations. The laboratory must have a system in place to ensure that it documents all complaints and problems reported to the laboratory...

  1. Improved compliance by BPM-driven workflow automation.

    PubMed

    Holzmüller-Laue, Silke; Göde, Bernd; Fleischer, Heidi; Thurow, Kerstin

    2014-12-01

    Using methods and technologies of business process management (BPM) for the laboratory automation has important benefits (i.e., the agility of high-level automation processes, rapid interdisciplinary prototyping and implementation of laboratory tasks and procedures, and efficient real-time process documentation). A principal goal of the model-driven development is the improved transparency of processes and the alignment of process diagrams and technical code. First experiences of using the business process model and notation (BPMN) show that easy-to-read graphical process models can achieve and provide standardization of laboratory workflows. The model-based development allows one to change processes quickly and an easy adaption to changing requirements. The process models are able to host work procedures and their scheduling in compliance with predefined guidelines and policies. Finally, the process-controlled documentation of complex workflow results addresses modern laboratory needs of quality assurance. BPMN 2.0 as an automation language to control every kind of activity or subprocess is directed to complete workflows in end-to-end relationships. BPMN is applicable as a system-independent and cross-disciplinary graphical language to document all methods in laboratories (i.e., screening procedures or analytical processes). That means, with the BPM standard, a communication method of sharing process knowledge of laboratories is also available. © 2014 Society for Laboratory Automation and Screening.

  2. Proper laboratory notebook practices: protecting your intellectual property.

    PubMed

    Nickla, Jason T; Boehm, Matthew B

    2011-03-01

    A laboratory notebook contains a wealth of knowledge that can be critical for establishing evidence in support of intellectual property rights and for refuting claims of research misconduct. The proper type, organization, use, maintenance, and storage of laboratory notebooks should be a priority for everyone at research institutions. Failure to properly document research activities can lead to serious problems, including the loss of valuable patent rights. Consequences of improper laboratory notebook practices can be harsh; numerous examples are described in court cases and journal articles, indicating a need for research institutions to develop strict policies on the proper use and storage of research documentation.

  3. Increasing value and reducing waste in research design, conduct, and analysis.

    PubMed

    Ioannidis, John P A; Greenland, Sander; Hlatky, Mark A; Khoury, Muin J; Macleod, Malcolm R; Moher, David; Schulz, Kenneth F; Tibshirani, Robert

    2014-01-11

    Correctable weaknesses in the design, conduct, and analysis of biomedical and public health research studies can produce misleading results and waste valuable resources. Small effects can be difficult to distinguish from bias introduced by study design and analyses. An absence of detailed written protocols and poor documentation of research is common. Information obtained might not be useful or important, and statistical precision or power is often too low or used in a misleading way. Insufficient consideration might be given to both previous and continuing studies. Arbitrary choice of analyses and an overemphasis on random extremes might affect the reported findings. Several problems relate to the research workforce, including failure to involve experienced statisticians and methodologists, failure to train clinical researchers and laboratory scientists in research methods and design, and the involvement of stakeholders with conflicts of interest. Inadequate emphasis is placed on recording of research decisions and on reproducibility of research. Finally, reward systems incentivise quantity more than quality, and novelty more than reliability. We propose potential solutions for these problems, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Smart Electronic Laboratory Notebooks for the NIST Research Environment.

    PubMed

    Gates, Richard S; McLean, Mark J; Osborn, William A

    2015-01-01

    Laboratory notebooks have been a staple of scientific research for centuries for organizing and documenting ideas and experiments. Modern laboratories are increasingly reliant on electronic data collection and analysis, so it seems inevitable that the digital revolution should come to the ordinary laboratory notebook. The most important aspect of this transition is to make the shift as comfortable and intuitive as possible, so that the creative process that is the hallmark of scientific investigation and engineering achievement is maintained, and ideally enhanced. The smart electronic laboratory notebooks described in this paper represent a paradigm shift from the old pen and paper style notebooks and provide a host of powerful operational and documentation capabilities in an intuitive format that is available anywhere at any time.

  5. Smart Electronic Laboratory Notebooks for the NIST Research Environment

    PubMed Central

    Gates, Richard S.; McLean, Mark J.; Osborn, William A.

    2015-01-01

    Laboratory notebooks have been a staple of scientific research for centuries for organizing and documenting ideas and experiments. Modern laboratories are increasingly reliant on electronic data collection and analysis, so it seems inevitable that the digital revolution should come to the ordinary laboratory notebook. The most important aspect of this transition is to make the shift as comfortable and intuitive as possible, so that the creative process that is the hallmark of scientific investigation and engineering achievement is maintained, and ideally enhanced. The smart electronic laboratory notebooks described in this paper represent a paradigm shift from the old pen and paper style notebooks and provide a host of powerful operational and documentation capabilities in an intuitive format that is available anywhere at any time. PMID:26958447

  6. Intranet-based quality improvement documentation at the Veterans Affairs Maryland Health Care System.

    PubMed

    Borkowski, A; Lee, D H; Sydnor, D L; Johnson, R J; Rabinovitch, A; Moore, G W

    2001-01-01

    The Pathology and Laboratory Medicine Service of the Veterans Affairs Maryland Health Care System is inspected biannually by the College of American Pathologists (CAP). As of the year 2000, all documentation in the Anatomic Pathology Section is available to all staff through the VA Intranet. Signed, supporting paper documents are on file in the office of the department chair. For the year 2000 CAP inspection, inspectors conducted their document review by use of these Web-based documents, in which each CAP question had a hyperlink to the corresponding section of the procedure manual. Thus inspectors were able to locate the documents relevant to each question quickly and efficiently. The procedure manuals consist of 87 procedures for surgical pathology, 52 procedures for cytopathology, and 25 procedures for autopsy pathology. Each CAP question requiring documentation had from one to three hyperlinks to the corresponding section of the procedure manual. Intranet documentation allows for easier sharing among decentralized institutions and for centralized updates of the laboratory documentation. These documents can be upgraded to allow for multimedia presentations, including text search for key words, hyperlinks to other documents, and images, audio, and video. Use of Web-based documents can improve the efficiency of the inspection process.

  7. Specimen rejection in laboratory medicine: Necessary for patient safety?

    PubMed

    Dikmen, Zeliha Gunnur; Pinar, Asli; Akbiyik, Filiz

    2015-01-01

    The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the rejection criteria of the laboratory. In this study, we aimed to evaluate the sample rejection ratios according to the types of pre-preanalytical errors and collection areas. The samples sent to the emergency laboratory were recorded during 12 months between January to December, 2013 in which 453,171 samples were received and 27,067 specimens were rejected. Rejection ratios was 2.5% for biochemistry tests, 3.2% for complete blood count (CBC), 9.8% for blood gases, 9.2% for urine analysis, 13.3% for coagulation tests, 12.8% for therapeutic drug monitoring, 3.5% for cardiac markers and 12% for hormone tests. The most frequent rejection reasons were fibrin clots (28%) and inadequate volume (9%) for biochemical tests. Clotted samples (35%) and inadequate volume (13%) were the major causes for coagulation tests, blood gas analyses and CBC. The ratio of rejected specimens was higher in the EDs (40%) compared to ICUs (30%) and inpatient services (28%). The highest rejection ratio was observed in neurology ICU (14%) among the ICUs and internal medicine inpatient service (10%) within inpatient clinics. We detected an overall specimen rejection rate of 6% in emergency laboratory. By documentation of rejected samples and periodic training of healthcare personnel, we expect to decrease sample rejection ratios below 2%, improve total quality management of the emergency laboratory and promote patient safety.

  8. College of American Pathologists' laboratory standards for next-generation sequencing clinical tests.

    PubMed

    Aziz, Nazneen; Zhao, Qin; Bry, Lynn; Driscoll, Denise K; Funke, Birgit; Gibson, Jane S; Grody, Wayne W; Hegde, Madhuri R; Hoeltge, Gerald A; Leonard, Debra G B; Merker, Jason D; Nagarajan, Rakesh; Palicki, Linda A; Robetorye, Ryan S; Schrijver, Iris; Weck, Karen E; Voelkerding, Karl V

    2015-04-01

    The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical testing. The number of laboratories offering NGS-based tests has also grown considerably in the past few years, despite the fact that specific Clinical Laboratory Improvement Amendments of 1988/College of American Pathologists (CAP) laboratory standards had not yet been developed to regulate this technology. To develop a checklist for clinical testing using NGS technology that sets standards for the analytic wet bench process and for bioinformatics or "dry bench" analyses. As NGS-based clinical tests are new to diagnostic testing and are of much greater complexity than traditional Sanger sequencing-based tests, there is an urgent need to develop new regulatory standards for laboratories offering these tests. To develop the necessary regulatory framework for NGS and to facilitate appropriate adoption of this technology for clinical testing, CAP formed a committee in 2011, the NGS Work Group, to deliberate upon the contents to be included in the checklist. Results . -A total of 18 laboratory accreditation checklist requirements for the analytic wet bench process and bioinformatics analysis processes have been included within CAP's molecular pathology checklist (MOL). This report describes the important issues considered by the CAP committee during the development of the new checklist requirements, which address documentation, validation, quality assurance, confirmatory testing, exception logs, monitoring of upgrades, variant interpretation and reporting, incidental findings, data storage, version traceability, and data transfer confidentiality.

  9. Software Engineering Laboratory (SEL) relationships, models, and management rules

    NASA Technical Reports Server (NTRS)

    Decker, William; Hendrick, Robert; Valett, Jon D.

    1991-01-01

    Over 50 individual Software Engineering Laboratory (SEL) research results, extracted from a review of published SEL documentation, that can be applied directly to managing software development projects are captured. Four basic categories of results are defined and discussed - environment profiles, relationships, models, and management rules. In each category, research results are presented as a single page that summarizes the individual result, lists potential uses of the result by managers, and references the original SEL documentation where the result was found. The document serves as a concise reference summary of applicable research for SEL managers.

  10. Waste certification program plan for Oak Ridge National Laboratory. Revision 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1997-09-01

    This document defines the waste certification program (WCP) developed for implementation at Oak Ridge National Laboratory (ORNL). The document describes the program structure, logic, and methodology for certification of ORNL wastes. The purpose of the WCP is to provide assurance that wastes are properly characterized and that the Waste Acceptance Criteria (WAC) for receiving facilities are met. The program meets the waste certification requirements for mixed (both radioactive and hazardous) and hazardous [including polychlorinated biphenyls (PCB)] waste. Program activities will be conducted according to ORNL Level 1 document requirements.

  11. Purple Computational Environment With Mappings to ACE Requirements for the General Availability User Environment Capabilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barney, B; Shuler, J

    2006-08-21

    Purple is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Lawrence Livermore National Laboratory (LLNL). The Purple Computational Environment documents the capabilities and the environment provided for the FY06 LLNL Level 1 General Availability Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and Sandia National Laboratories, but also documents needs of the LLNL and Alliance users working in the unclassified environment. Additionally,more » the Purple Computational Environment maps the provided capabilities to the Trilab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the General Availability user environment capabilities of the ASC community. Appendix A lists these requirements and includes a description of ACE requirements met and those requirements that are not met for each section of this document. The Purple Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the Tri-lab community.« less

  12. Test Plan for the Wake Steering Experiment at the Scaled Wind Farm Technology (SWiFT) Facility.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Naughton, Brian Thomas

    This document is a test plan describing the objectives, configuration, procedures, reporting, roles, and responsibilities for conducting the joint Sandia National Laboratories and National Renewable Energy Laboratory Wake Steering Experiment at the Sandia Scaled Wind Farm Technology (SWiFT) facility near Lubbock, Texas in 2016 and 2017 . The purpose of this document is to ensure the test objectives and procedures are sufficiently detailed such that al l involved personnel are able to contribute to the technical success of the test. This document is not intended to address safety explicitly which is addressed in a separate document listed in the referencesmore » titled Sandia SWiFT Facility Site Operations Manual . Both documents should be reviewed by all test personnel.« less

  13. Software validation applied to spreadsheets used in laboratories working under ISO/IEC 17025

    NASA Astrophysics Data System (ADS)

    Banegas, J. M.; Orué, M. W.

    2016-07-01

    Several documents deal with software validation. Nevertheless, more are too complex to be applied to validate spreadsheets - surely the most used software in laboratories working under ISO/IEC 17025. The method proposed in this work is intended to be directly applied to validate spreadsheets. It includes a systematic way to document requirements, operational aspects regarding to validation, and a simple method to keep records of validation results and modifications history. This method is actually being used in an accredited calibration laboratory, showing to be practical and efficient.

  14. Quality Assurance Specifications for Planetary Protection Assays

    NASA Astrophysics Data System (ADS)

    Baker, Amy

    As the European Space Agency planetary protection (PP) activities move forward to support the ExoMars and other planetary missions, it will become necessary to increase staffing of labo-ratories that provide analyses for these programs. Standardization of procedures, a comprehen-sive quality assurance program, and unilateral training of personnel will be necessary to ensure that the planetary protection goals and schedules are met. The PP Quality Assurance/Quality Control (QAQC) program is designed to regulate and monitor procedures performed by labora-tory personnel to ensure that all work meets data quality objectives through the assembly and launch process. Because personnel time is at a premium and sampling schedules are often de-pendent on engineering schedules, it is necessary to have flexible staffing to support all sampling requirements. The most productive approach to having a competent and flexible work force is to establish well defined laboratory procedures and training programs that clearly address the needs of the program and the work force. The quality assurance specification for planetary protection assays has to ensure that labora-tories and associated personnel can demonstrate the competence to perform assays according to the applicable standard AD4. Detailed subjects included in the presentation are as follows: • field and laboratory control criteria • data reporting • personnel training requirements and certification • laboratory audit criteria. Based upon RD2 for primary and secondary validation and RD3 for data quality objectives, the QAQC will provide traceable quality assurance safeguards by providing structured laboratory requirements for guidelines and oversight including training and technical updates, standardized documentation, standardized QA/QC checks, data review and data archiving.

  15. One Moon, many measurements 1: Radiance values

    NASA Astrophysics Data System (ADS)

    Pieters, C. M.; Boardman, J. W.; Ohtake, M.; Matsunaga, T.; Haruyama, J.; Green, R. O.; Mall, U.; Staid, M. I.; Isaacson, P. J.; Yokota, Y.; Yamamoto, S.; Besse, S.; Sunshine, J. M.

    2013-09-01

    Several modern optical instruments orbited the Moon during 2008 and 2009 onboard the SELENE and Chandrayaan-1 spacecraft and provided a welcomed feast of spectroscopic data to be used for scientific analyses. The different spatial and spectral resolutions of these sensors along with diverse illumination geometry during data acquisition make each set of data unique, and each instrument contributes special value to integrated science analyses. In order to provide the maximum science benefit, we have undertaken a careful cross-validation of radiance data among these orbital instruments and also a set of systematic data acquired using Earth-based telescopes. Most radiance values at 750 nm fall between 0 and 100 W/(m2 μm sr), but a small important fraction can be up to ×2 to ×3 that value, with the largest values occurring at the highest spatial resolution. All instruments are in agreement about overall spectral properties of lunar materials, but small systematic differences are documented between instruments. Lunar radiance values measured with remote sensors for landing sites are all not as high as that estimated from laboratory measurements of returned soil. This is largely because laboratory measurements of lunar soils cannot retain or duplicate the fine structure of lunar regolith found in the natural space environment.

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dimmick, Ross

    This document contains updates to the Supplemental Information Sandia National Laboratories/New Mexico Site-Wide Environmental Impact Statement Source Documents that were developed in 2010. In general, this addendum provides calendar year 2010 data, along with changes or additions to text in the original documents.

  17. Cyber Incidents Involving Control Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robert J. Turk

    2005-10-01

    The Analysis Function of the US-CERT Control Systems Security Center (CSSC) at the Idaho National Laboratory (INL) has prepared this report to document cyber security incidents for use by the CSSC. The description and analysis of incidents reported herein support three CSSC tasks: establishing a business case; increasing security awareness and private and corporate participation related to enhanced cyber security of control systems; and providing informational material to support model development and prioritize activities for CSSC. The stated mission of CSSC is to reduce vulnerability of critical infrastructure to cyber attack on control systems. As stated in the Incident Managementmore » Tool Requirements (August 2005) ''Vulnerability reduction is promoted by risk analysis that tracks actual risk, emphasizes high risk, determines risk reduction as a function of countermeasures, tracks increase of risk due to external influence, and measures success of the vulnerability reduction program''. Process control and Supervisory Control and Data Acquisition (SCADA) systems, with their reliance on proprietary networks and hardware, have long been considered immune to the network attacks that have wreaked so much havoc on corporate information systems. New research indicates this confidence is misplaced--the move to open standards such as Ethernet, Transmission Control Protocol/Internet Protocol, and Web technologies is allowing hackers to take advantage of the control industry's unawareness. Much of the available information about cyber incidents represents a characterization as opposed to an analysis of events. The lack of good analyses reflects an overall weakness in reporting requirements as well as the fact that to date there have been very few serious cyber attacks on control systems. Most companies prefer not to share cyber attack incident data because of potential financial repercussions. Uniform reporting requirements will do much to make this information available to Department of Homeland Security (DHS) and others who require it. This report summarizes the rise in frequency of cyber attacks, describes the perpetrators, and identifies the means of attack. This type of analysis, when used in conjunction with vulnerability analyses, can be used to support a proactive approach to prevent cyber attacks. CSSC will use this document to evolve a standardized approach to incident reporting and analysis. This document will be updated as needed to record additional event analyses and insights regarding incident reporting. This report represents 120 cyber security incidents documented in a number of sources, including: the British Columbia Institute of Technology (BCIT) Industrial Security Incident Database, the 2003 CSI/FBI Computer Crime and Security Survey, the KEMA, Inc., Database, Lawrence Livermore National Laboratory, the Energy Incident Database, the INL Cyber Incident Database, and other open-source data. The National Memorial Institute for the Prevention of Terrorism (MIPT) database was also interrogated but, interestingly, failed to yield any cyber attack incidents. The results of this evaluation indicate that historical evidence provides insight into control system related incidents or failures; however, that the limited available information provides little support to future risk estimates. The documented case history shows that activity has increased significantly since 1988. The majority of incidents come from the Internet by way of opportunistic viruses, Trojans, and worms, but a surprisingly large number are directed acts of sabotage. A substantial number of confirmed, unconfirmed, and potential events that directly or potentially impact control systems worldwide are also identified. Twelve selected cyber incidents are presented at the end of this report as examples of the documented case studies (see Appendix B).« less

  18. Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    FULLER, R.K.

    1999-02-23

    This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects.more » The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.« less

  19. Final report for 105-N Basin sediment disposition task, phase 2 -- samples BOMPC8 and BOMPC9

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Esch, R.A.

    1998-02-05

    This document is the final report deliverable for Phase 2 analytical work for the 105-N Basin Sediment Disposition Task. On December 23, 1997, ten samples were received at the 222-S Laboratory as follows: two (2) bottles of potable water, six (6) samples for process control testing and two (2) samples for characterization. Analyses were performed in accordance with the Letter of Instruction for Phase 2 Analytical Work for the 105-N Basin Sediment Disposition Task (Logan and Kessner, 1997) (Attachment 7) and 105-N Basin Sediment Disposition Phase-Two Sampling and Analysis Plan (SAP) (Smith, 1997). The analytical results are included in Tablemore » 1. This document provides the values of X/Qs for the onsite and offsite receptors, taking into account the building wake and the atmospheric stability effects. X/Qs values for the potential fire accident were also calculated. In addition, the unit dose were calculated for the mixtures of isotopes.« less

  20. 42 CFR 493.1425 - Standard; Testing personnel responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laboratory's quality control policies, document all quality control activities, instrument and procedural... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1425 Standard; Testing personnel...

  1. Photovoltaic module certification and laboratory accreditation criteria development

    NASA Astrophysics Data System (ADS)

    Osterwald, Carl R.; Zerlaut, Gene; Hammond, Robert; D'Aiello, Robert

    1996-01-01

    This paper overviews a model product certification and test laboratory accreditation program for photovoltaic (PV) modules that was recently developed by the National Renewable Energy Laboratory and Arizona State University. The specific objective of this project was to produce a document that details the equipment, facilities, quality assurance procedures, and technical expertise an accredited laboratory needs for performance and qualification testing of PV modules, along with the specific tests needed for a module design to be certified. The document was developed in conjunction with a criteria development committee consisting of representatives from 30 U.S. PV manufacturers, end users, standards and codes organizations, and testing laboratories. The intent is to lay the groundwork for a future U.S. PV certification and accreditation program that will be beneficial to the PV industry as a whole.

  2. Antidoping programme and biological monitoring before and during the 2014 FIFA World Cup Brazil

    PubMed Central

    Baume, Norbert; Jan, Nicolas; Emery, Caroline; Mandanis, Béatrice; Schweizer, Carine; Giraud, Sylvain; Leuenberger, Nicolas; Marclay, François; Nicoli, Raul; Perrenoud, Laurent; Robinson, Neil; Dvorak, Jiri; Saugy, Martial

    2015-01-01

    Background The FIFA has implemented an important antidoping programme for the 2014 FIFA World Cup. Aim To perform the analyses before and during the World Cup with biological monitoring of blood and urine samples. Methods All qualified players from the 32 teams participating in the World Cup were tested out-of-competition. During the World Cup, 2–8 players per match were tested. Over 1000 samples were collected in total and analysed in the WADA accredited Laboratory of Lausanne. Results The quality of the analyses was at the required level as described in the WADA technical documents. The urinary steroid profiles of the players were stable and consistent with previously published papers on football players. During the competition, amphetamine was detected in a sample collected on a player who had a therapeutic use exemption for attention deficit hyperactivity disorder. The blood passport data showed no significant difference in haemoglobin values between out-of-competition and postmatch samples. Conclusions Logistical issues linked to biological samples collection, and the overseas shipment during the World Cup did not impair the quality of the analyses, especially when used as the biological passport of football players. PMID:25878079

  3. Procedures of Exercise Physiology Laboratories

    NASA Technical Reports Server (NTRS)

    Bishop, Phillip A.; Fortney, Suzanne; Greenisen, Michael; Siconolfi, Steven F.; Bamman, Marcas M.; Moore, Alan D., Jr.; Squires, William

    1998-01-01

    This manual describes the laboratory methods used to collect flight crew physiological performance data at the Johnson Space Center. The Exercise Countermeasures Project Laboratory is a standard physiology laboratory; only the application to the study of human physiological adaptations to spaceflight is unique. In the absence of any other recently published laboratory manual, this manual should be a useful document staffs and students of other laboratories.

  4. List of Laboratories Approved by EPA for the Fourth Unregulated Contaminant Monitoring Rule (UCMR 4)

    EPA Pesticide Factsheets

    This document provides a list of laboratories that met the Unregulated Contaminant Monitoring Rule 4 (UCMR 4) Laboratory Approval Program application and Proficiency Testing (PT) criteria for the methods indicated.

  5. List of Laboratories Approved by EPA for the Third Unregulated Contaminant Monitoring Rule (UCMR 3)

    EPA Pesticide Factsheets

    This document provides a list of laboratories that met the Unregulated Contaminant Monitoring Rule 3 (UCMR 3) Laboratory Approval Program application and Proficiency Testing (PT) criteria for the methods indicated.

  6. ISDP salt batch #2 supernate qualification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.; Nash, C. A.; Fink, S. D.

    2009-01-05

    This report covers the laboratory testing and analyses of the second Integrated Salt Disposition Project (ISDP) salt supernate samples, performed in support of initial radioactive operations of Actinide Removal Process (ARP) and Modular Caustic-Side Solvent Extraction Unit (MCU). Major goals of this work include characterizing Tank 22H supernate, characterizing Tank 41H supernate, verifying actinide and strontium adsorption with a standard laboratory-scale test using monosodium titanate (MST) and filtration, and checking cesium mass transfer behavior for the MCU solvent performance when contacted with the liquid produced from MST contact. This study also includes characterization of a post-blend Tank 49H sample asmore » part of the Nuclear Criticality Safety Evaluation (NCSE). This work was specified by Task Technical Request and by Task Technical and Quality Assurance Plan (TTQAP). In addition, a sampling plan will be written to guide analytical future work. Safety and environmental aspects of the work were documented in a Hazard Assessment Package.« less

  7. Summary of the 1987 soil sampling effort at the Idaho National Engineering Laboratory Test Reactor Area Paint Shop Ditch

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wood, T.R.; Knight, J.L.; Hertzler, C.L.

    1989-08-01

    Sampling of the Test Reactor Area (TRA) Paint Shop Ditch at the Idaho National Engineering Laboratory was initiated in compliance with the Interim Agreement between the Department of Energy (DOE) and the Environmental Protection Agency (EPA). Sampling of the TRA Paint Shop Ditch was done as part of the Action Plan to achieve and maintain compliance with the Resource Conservation and Recovery Act (RCRA) and applicable regulations. It is the purpose of this document to provide a summary of the July 6, 1987 sampling activities that occurred in ditch west of Building TRA-662, which housed the TRA Paint Shop inmore » 1987. This report will give a narrative description of the field activities, locations of collected samples, discuss the sampling procedures and the chemical analyses. Also included in the scope of this report is to bring together data and reports on the TRA Paint Shop Ditch for archival purposes. 6 refs., 10 figs., 8 tabs.« less

  8. Evaluation of Using Caged Clams to Monitor Contaminated Groundwater Exposure in the Near-Shore Environment of the Hanford Site 300 Area

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larson, Kyle B.; Poston, Ted M.; Tiller, Brett L.

    2008-01-31

    The Asiatic clam (Corbicula fluminea) has been identified as an indicator species for locating and monitoring contaminated groundwater in the Columbia River. Pacific Northwest National Laboratory conducted a field study to explore the use of caged Asiatic clams to monitor contaminated groundwater upwelling in the 300 Area near-shore environment and assess seasonal differences in uranium uptake in relation to seasonal flow regimes of the Columbia River. Additional objectives included examining the potential effects of uranium accumulation on growth, survival, and tissue condition of the clams. This report documents the field conditions and procedures, laboratory procedures, and statistical analyses used inmore » collecting samples and processing the data. Detailed results are presented and illustrated, followed by a discussion comparing uranium concentrations in Asiatic clams collected at the 300 Area and describing the relationship between river discharge, groundwater indicators, and uranium in clams. Growth and survival, histology, and other sources of environmental variation also are discussed.« less

  9. In-tank precipitation facility (ITP) and H-Tank Farm (HTF) geotechnical report, WSRC-TR-95-0057, Revision 0, Volume 5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    A geotechnical study has been completed in H-Area for the In-Tank Precipitation Facility (ITP) and the balance of the H-Area Tank Farm (HTF) at the Savannah River Site (SRS) in South Carolina. The study consisted of subsurface field exploration, field and laboratory testing, and engineering analyses. The purpose of these investigations is to evaluate the overall stability of the H-Area tanks under static and dynamic conditions. The objectives of the study are to define the site-specific geological conditions at ITP and HTF, obtain engineering properties for the assessment of the stability of the native soils and embankment under static andmore » dynamic loads (i.e., slope stability, liquefaction potential, and potential settlements), and derive properties for soil-structure interaction studies. This document (Volume 5) contains the laboratory test results for the In-Tank Precipitation Facility (ITP) and H-Tank Farm (HTF) Geotechnical Report.« less

  10. Estimation of constitutive parameters for the Belridge Diatomite, South Belridge Diatomite Field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fossum, A.F.; Fredrich, J.T.

    1998-06-01

    A cooperative national laboratory/industry research program was initiated in 1994 that improved understanding of the geomechanical processes causing well casing damage during oil production from weak, compactible formations. The program focused on the shallow diatomaceous oil reservoirs located in California`s San Joaquin Valley, and combined analyses of historical field data, experimental determination of rock mechanical behavior, and geomechanical simulation of the reservoir and overburden response to production and injection. Sandia National Laboratories` quasi-static, large-deformation structural mechanics finite element code JAS3D was used to perform the three-dimensional geomechanical simulations. One of the material models implemented in JAS3D to simulate the time-independentmore » inelastic (non-linear) deformation of geomaterials is a generalized version of the Sandler and Rubin cap plasticity model (Sandler and Rubin, 1979). This report documents the experimental rock mechanics data and material cap plasticity models that were derived to describe the Belridge Diatomite reservoir rock at the South Belridge Diatomite Field, Section 33.« less

  11. Risk prediction for chronic kidney disease progression using heterogeneous electronic health record data and time series analysis.

    PubMed

    Perotte, Adler; Ranganath, Rajesh; Hirsch, Jamie S; Blei, David; Elhadad, Noémie

    2015-07-01

    As adoption of electronic health records continues to increase, there is an opportunity to incorporate clinical documentation as well as laboratory values and demographics into risk prediction modeling. The authors develop a risk prediction model for chronic kidney disease (CKD) progression from stage III to stage IV that includes longitudinal data and features drawn from clinical documentation. The study cohort consisted of 2908 primary-care clinic patients who had at least three visits prior to January 1, 2013 and developed CKD stage III during their documented history. Development and validation cohorts were randomly selected from this cohort and the study datasets included longitudinal inpatient and outpatient data from these populations. Time series analysis (Kalman filter) and survival analysis (Cox proportional hazards) were combined to produce a range of risk models. These models were evaluated using concordance, a discriminatory statistic. A risk model incorporating longitudinal data on clinical documentation and laboratory test results (concordance 0.849) predicts progression from state III CKD to stage IV CKD more accurately when compared to a similar model without laboratory test results (concordance 0.733, P<.001), a model that only considers the most recent laboratory test results (concordance 0.819, P < .031) and a model based on estimated glomerular filtration rate (concordance 0.779, P < .001). A risk prediction model that takes longitudinal laboratory test results and clinical documentation into consideration can predict CKD progression from stage III to stage IV more accurately than three models that do not take all of these variables into consideration. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association.

  12. Q fever in Spain: acute and chronic cases, 1981-1985.

    PubMed

    Tellez, A; Sainz, C; Echevarria, C; de Carlos, S; Fernandez, M V; Leon, P; Brezina, R

    1988-01-01

    Two hundred forty-nine cases of Q fever were documented at the laboratories of the Centro Nacional de Microbiología, Virología e Inmunología Sanitarias (CNMVIS) during the 5-year period 1981-1985. Two hundred thirty-four cases corresponded to acute infections, mostly sporadic but including two epidemics. The clinical presentation was respiratory in 74% of the cases and febrile in 18%. Fifteen cases, all but one of which were endocarditis, were categorized as chronic. The cases studied were referred from almost every region of Spain. The clinical and epidemiologic analyses and the number of cases reported permit only an approximation of the true incidence and characteristics of Q fever in Spain.

  13. Normalized-Difference Snow Index (NDSI)

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.; Riggs, George A.

    2010-01-01

    The Normalized-Difference Snow Index (NDSI) has a long history. 'The use of ratioing visible (VIS) and near-infrared (NIR) or short-wave infrared (SWIR) channels to separate snow and clouds was documented in the literature beginning in the mid-1970s. A considerable amount of work on this subject was conducted at, and published by, the Air Force Geophysics Laboratory (AFGL). The objective of the AFGL work was to discriminate snow cover from cloud cover using an automated algorithm to improve global cloud analyses. Later, automated methods that relied on the VIS/NIR ratio were refined substantially using satellite data In this section we provide a brief history of the use of the NDSI for mapping snow cover.

  14. Tank 241-AN-101, grab samples, 1AN-98-1, 1AN-98-2 and 1AN-98-3 analytical results for the final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    FULLER, R.K.

    1999-02-24

    This document is the final report for tank 241-AN-101 grab samples. Three grab samples 1AN-98-1, 1AN-98-2 and 1AN-98-3 were taken from riser 16 of tank 241-AN-101 on April 8, 1998 and received by the 222-S Laboratory on April 9, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program'' (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded.

  15. Life and Microgravity Spacelab (LMS)

    NASA Technical Reports Server (NTRS)

    Downey, James Patton (Compiler)

    1998-01-01

    This document reports the results and analyses presented at the Life and Microgravity Spacelab One Year Science Review meeting. The science conference was held in Montreal, Canada, on August 20-21, 1997, and was hosted by the Canadian Space Agency. The LMS payload flew on the Space Shuttle Columbia (STS-78) from June 20 - July 7, 1996. The LMS investigations were performed in a pressurized Spacelab module and the Shuttle middeck. Forty scientific experiments were performed in fields such as fluid physics, solidification of metals, alloys, and semiconductors, the growth of protein crystals, and animal, human, and plant life sciences. The results demonstrate the range of quality science that can be conducted utilizing orbital laboratories in microgravity.

  16. Heating and Cooling System Design for a Modern Transportable Container

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berger, Jason E.

    Sandia National Laboratories (SNL) has been tasked with the design of a modern transportable container (MTC) for use in high reliability transportation environments. The container is required to transport cargo capable of generating its own heat and operate under the United States’ climatic extremes. In response to these requirements, active heating and cooling is necessary to maintain a controlled environment inside the container. The following thesis project documents the design of an active heating, active cooling, and combined active heating and cooling system (now referred to as active heating and cooling systems) through computational thermal analyses, scoping of commercial systemmore » options, and mechanical integration with the container’s structure.« less

  17. Gearbox Reliability Collaborative Phase 3 Gearbox 3 Test

    DOE Data Explorer

    Keller, Jonathan (ORCID:0000000177243885)

    2016-12-28

    The GRC uses a combined gearbox testing, modeling, and analysis approach disseminating data and results to the industry and facilitating improvement of gearbox reliability. This test data describes the tests of GRC gearbox 3 in the National Wind Technology Center dynamometer and documents any modifications to the original test plan. It serves as a guide to interpret the publicly released data sets with brief analyses to illustrate the data. TDMS viewer and Solidworks software required to view data files. The National Renewable Energy Laboratory (NREL) Gearbox Reliability Collaborative (GRC) was established by the U.S. Department of Energy in 2006; its key goal is to understand the root causes of premature gearbox failures and improve their reliability.

  18. Gearbox Reliability Collaborative Phase 3 Gearbox 2 Test

    DOE Data Explorer

    Keller, Jonathan; Robb, Wallen

    2016-05-12

    The National Renewable Energy Laboratory (NREL) Gearbox Reliability Collaborative (GRC) was established by the U.S. Department of Energy in 2006; its key goal is to understand the root causes of premature gearbox failures and improve their reliability. The GRC uses a combined gearbox testing, modeling, and analysis approach disseminating data and results to the industry and facilitating improvement of gearbox reliability. This test data describes the tests of GRC gearbox 2 in the National Wind Technology Center dynamometer and documents any modifications to the original test plan. It serves as a guide to interpret the publicly released data sets with brief analyses to illustrate the data. TDMS viewer and Solidworks software required to view data files.

  19. Development of criteria for the use of asphalt-rubber as a Stress-Absorbing Membrane Interlayer (SAMI)

    NASA Astrophysics Data System (ADS)

    Newcomb, D. E.; McKeen, R. G.

    1983-12-01

    This report documents over 2 years of research efforts to characterize asphalt-rubber mixtures to be used in Stress-Absorbing Membrane Interlayers (SAMI). The purpose of these SAMIs is to retard or prevent reflection cracking in asphalt-concrete overlays. Several laboratory experiments and one field trial were conducted to define significant test methods and parameters for incorporation into construction design and specification documents. Test methods used in this study included a modified softening point test, force-ductility, and Schweyer viscosity. Variables investigated included (1) Laboratory-mixing temperature; (2) Rubber type; (3) Laboratory storage time; (4) Laboratory storage condition; (5) Laboratory batch replication; (6) Laboratory mixing time; (7) Field mixing time; (8) Laboratory test temperature; (9) Force-Ductility elongation rates; and (10) Asphalt grade. It was found that mixing temperature, mixing time, rubber type, and asphalt grade all have significant effects upon the behavior of asphalt-rubber mixtures. Significant variability was also noticed in different laboratory batch replications. Varying laboratory test temperature and force-ductility elongation rate revealed further differences in asphalt-rubber mixtures.

  20. Laboratory Safety Guide for Arkansas K-12 Schools.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    This document presents laboratory safety rules for Arkansas K-12 schools which were developed by the Arkansas Science Teachers Association (ASTA) and the Arkansas Department of Education (ADE). Contents include: (1) "Laboratory Safety Guide for Arkansas K-12 Schools"; (2) "Safety Considerations"; (3) "Safety Standards for Science Laboratories";…

  1. Differences in reporting of analyses in internal company documents versus published trial reports: comparisons in industry-sponsored trials in off-label uses of gabapentin.

    PubMed

    Vedula, S Swaroop; Li, Tianjing; Dickersin, Kay

    2013-01-01

    Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our objective was to compare the description of types of analyses and criteria for including participants in the publication (i.e., what was reported) with descriptions in the corresponding internal company documents (i.e., what was planned and what was done). Trials were for off-label uses of gabapentin sponsored by Pfizer and Parke-Davis, and documents were obtained through litigation. For each trial, we compared internal company documents (protocols, statistical analysis plans, and research reports, all unpublished), with publications. One author extracted data and another verified, with a third person verifying discordant items and a sample of the rest. Extracted data included the number of participants randomized and analyzed for efficacy, and types of analyses for efficacy and safety and their definitions (i.e., criteria for including participants in each type of analysis). We identified 21 trials, 11 of which were published randomized controlled trials, and that provided the documents needed for planned comparisons. For three trials, there was disagreement on the number of randomized participants between the research report and publication. Seven types of efficacy analyses were described in the protocols, statistical analysis plans, and publications, including ITT and six others. The protocol or publication described ITT using six different definitions, resulting in frequent disagreements between the two documents (i.e., different numbers of participants were included in the analyses). Descriptions of analyses conducted did not agree between internal company documents and what was publicly reported. Internal company documents provide extensive documentation of methods planned and used, and trial findings, and should be publicly accessible. Reporting standards for randomized controlled trials should recommend transparent descriptions and definitions of analyses performed and which study participants are excluded.

  2. Waste certification program plan for Oak Ridge National Laboratory. Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Orrin, R.C.

    1997-05-01

    This document defines the waste certification program developed for implementation at Oak Ridge National Laboratory (ORNL). The document describes the program structure, logic, and methodology for certification of ORNL wastes. The purpose of the waste certification program is to provide assurance that wastes are properly characterized and that the Waste Acceptance Criteria (WAC) for receiving facilities are met. The program meets the waste certification requirements outlined in US Department of Energy (DOE) Order 5820.2A, Radioactive Waste Management, and ensures that 40 CFR documentation requirements for waste characterization are met for mixed (both radioactive and hazardous) and hazardous (including polychlorinated biphenyls)more » waste. Program activities will be conducted according to ORNL Level 1 document requirements.« less

  3. Field and laboratory analyses of water from the Columbia aquifer in Eastern Maryland

    USGS Publications Warehouse

    Bachman, L.J.

    1984-01-01

    Field and laboratory analyses of pH, alkalinity, and specific conductance from water samples collected from the Columbia aquifer on the Delmarva Peninsula in eastern Maryland were compared to determine if laboratory analyses could be used for making regional water-quality interpretations. Kruskal-Wallis tests of field and laboratory data indicate that the difference between field and laboratory values is usually not enough to affect the outcome of the statistical tests. Thus, laboratory measurements of these constituents may be adequate for making certain regional water-quality interpretations, although they may result in errors if used for geochemical interpretations.

  4. EPA Contract Laboratory Program Statement of Work for Inorganic Superfund Methods Multi-Media, Multi-Concentration ISM02.3

    EPA Pesticide Factsheets

    This document contains analytical methods for the analysis of metals and cyanide in environmental samples. It also contains contractual requirements for laboratories participating in Superfund's Contract Laboratory Program.

  5. EPA Contract Laboratory Program Statement of Work for Inorganic Superfund Methods Multi-Media, Multi-Concentration ISM02.4

    EPA Pesticide Factsheets

    This document contains analytical methods for the analysis of metals and cyanide in environmental samples. It also contains contractual requirements for laboratories participating in Superfund's Contract Laboratory Program.

  6. Aviation System Analysis Capability Executive Assistant Analyses

    NASA Technical Reports Server (NTRS)

    Roberts, Eileen; Kostiuk, Peter

    1999-01-01

    This document describes the analyses that may be incorporated into the Aviation System Analysis Capability Executive Assistant. The document will be used as a discussion tool to enable NASA and other integrated aviation system entities to evaluate, discuss, and prioritize analyses.

  7. GC-C-IRMS in routine doping control practice: 3 years of drug testing data, quality control and evolution of the method.

    PubMed

    Polet, Michael; Van Eenoo, Peter

    2015-06-01

    In order to detect the misuse of endogenous anabolic steroids, doping control laboratories require methods that allow differentiation between endogenous steroids and their synthetic copies. Gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) is capable of measuring the carbon isotope ratio of urinary steroids and this allows differentiation between both. GC-C-IRMS and its application to doping control has evolved a lot during the last decade and so have the World Anti-Doping Agency (WADA) technical documents that describe how GC-C-IRMS should be applied. Especially the WADA technical document of 2014 introduced a number of obligatory quality controls and a fixed methodology that should be used by all the doping control laboratories. This document imposed more uniform methods between the laboratories in order to decrease the interlaboratory standard deviation and acquire similar results for the analysis of the same urine samples. In this paper, 3 years of drug testing data of our GC-C-IRMS method in routine doping control practice is described, with an emphasis on the new WADA technical document and its implementation. Useful data for other doping control laboratories is presented focussing on general method setup, quality control and data collected from routine samples. The paper concentrates on how IRMS results shift or remain similar by switching to the 2014 WADA technical document and gives insight in a straightforward approach to calculate the measurement uncertainty.

  8. An Inquiry into Testing of Information Retrieval Systems. Comparative Systems Laboratory Final Technical Report, Part III: CSL Related Studies.

    ERIC Educational Resources Information Center

    Zull, Carolyn Gifford, Ed.; And Others

    This third volume of the Comparative Systems Laboratory (CSL) Final Technical Report is a collection of relatively independent studies performed on CSL materials. Covered in this document are studies on: (1) properties of files, including a study of the growth rate of a dictionary of index terms as influenced by number of documents in the file and…

  9. Evidence Study Guide.

    DTIC Science & Technology

    1987-04-01

    involving novel scientific evidence, e.g., the drug-induced or hypnosis -induced interview of a witness. Although the rules on experts contain no reference...under the Fed.R.Evid. Among the evidence which Nil.R.Evid. 803(6) makes admissible are forensic laboratory reports and chain of custody documents. The...34 inclusion of forensic laboratory reports and chain of custody documents in this Mil.R.Evid. is in conflict with the legislative history of

  10. Correct coding for laboratory procedures during assisted reproductive technology cycles.

    PubMed

    2016-04-01

    This document provides updated coding information for services related to assisted reproductive technology procedures. This document replaces the 2012 ASRM document of the same name. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  11. A profile of sports science research (1983-2003).

    PubMed

    Williams, Stephen John; Kendall, Lawrence R

    2007-08-01

    A majority of sports science research is undertaken in universities and dedicated research centres, such as institutes of sport. Reviews of literature analysing and categorising research have been carried out, but categories identified have been limited to research design and data gathering techniques. Hence there is a need to include categories such as discipline, subjects and targeted sport. A study was conducted using document analysis method to gather data that described and categorised performance-based sports science research projects in Australian universities and institutes of sport. An instrument was designed that could be used by researchers to analyse and profile research in the area of sports science. The instrument contained six categories: targeted sport, primary study area, participant type, research setting, methodology and data gathering techniques. Research documents analysed consisted of 725 original unpublished research reports/theses. Results showed that over two-thirds of research projects were targeted to specific sports and, of this group, nearly half involved four sports: cycling, rowing, athletics and swimming. Overall, physiology was the most researched scientific discipline. The most frequently used research method was experimental design, and the most frequently used data gathering technique was physiological (performance) measures. Two-thirds of research was conducted in laboratory settings, and nearly half of the research was conducted with elite or sub-elite athletes as participants/subjects. The findings of this study provide an overall synopsis of performance-based sports science research conducted in Australia over the last 20 years, and should be of considerable importance in the ongoing development of sports science research policy in Australia.

  12. Sampling and analyses plan for tank 103 at the 219-S waste handling facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    FOWLER, K.D.

    1999-06-23

    This document describes the sampling and analysis activities associated with taking a Resource Conservation and Recovery Act (RCRA) protocol sample of the waste from Tank 103 at the 21 9-S Waste Handling Facility treatment storage, andlor disposal (TSD) unit at the 2224 Laboratory complex. This sampling and analyses is required based on negotiations between the State of Washington Department of Ecology (Ecology) and the Department of Energy, Richland Operations, (RL) in letters concerning the TPA Change Form M-32-98-01. In a letter from George H. Sanders, RL to Moses N. Jaraysi, Ecology, dated January 28,1999, it was noted that ''Prior tomore » the Tank 103 waste inventory transfer, a RCRA protocol sample of the waste will be obtained and tested for the constituents contained on the Part A, Form 3 Permit Application for the 219-S Waste Handling Facility.'' In the April 2, 1999 letter, from Brenda L. Becher-Khaleel, Ecology to James, E. Rasmussen, RL, and William O. Adair, FDH, Ecology states that the purpose of these analyses is to provide information and justification for leaving Tank 103 in an isolated condition in the 2194 TSD unit until facility closure. The data may also be used at some future date in making decisions regarding closure methodology for Tank 103. Ecology also notes that As Low As Reasonably Achievable (ALARA) concerns may force deviations from some SW-846 protocol. Every effort will be made to accommodate requirements as specified. Deviations from SW-846 will be documented in accordance with HASQARD.« less

  13. Specimen rejection in laboratory medicine: Necessary for patient safety?

    PubMed Central

    Dikmen, Zeliha Gunnur; Pinar, Asli; Akbiyik, Filiz

    2015-01-01

    Introduction The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the rejection criteria of the laboratory. In this study, we aimed to evaluate the sample rejection ratios according to the types of pre-preanalytical errors and collection areas. Materials and methods The samples sent to the emergency laboratory were recorded during 12 months between January to December, 2013 in which 453,171 samples were received and 27,067 specimens were rejected. Results Rejection ratios was 2.5% for biochemistry tests, 3.2% for complete blood count (CBC), 9.8% for blood gases, 9.2% for urine analysis, 13.3% for coagulation tests, 12.8% for therapeutic drug monitoring, 3.5% for cardiac markers and 12% for hormone tests. The most frequent rejection reasons were fibrin clots (28%) and inadequate volume (9%) for biochemical tests. Clotted samples (35%) and inadequate volume (13%) were the major causes for coagulation tests, blood gas analyses and CBC. The ratio of rejected specimens was higher in the EDs (40%) compared to ICUs (30%) and inpatient services (28%). The highest rejection ratio was observed in neurology ICU (14%) among the ICUs and internal medicine inpatient service (10%) within inpatient clinics. Conclusions We detected an overall specimen rejection rate of 6% in emergency laboratory. By documentation of rejected samples and periodic training of healthcare personnel, we expect to decrease sample rejection ratios below 2%, improve total quality management of the emergency laboratory and promote patient safety. PMID:26527231

  14. NACA Conference on Aircraft Loads, Structures, and Flutter

    NASA Technical Reports Server (NTRS)

    1957-01-01

    This document contains reproductions of technical papers on some of the most recent research results on aircraft loads, flutter, and structures from the NACA laboratories. These papers were presented by members of the staff of the NACA laboratories at the Conference held at the Langley Aeronautical Laboratory March 5, 6, and 7, 1957. The primary purpose of this Conference was to convey to contractors of the military services and others concerned with the design of aircraft these recent research results and to provide those attending an opportunity to discuss the results. The papers in this document are in the same form in which they were presented at the Conference in order to facilitate their prompt distribution. The original presentation and this record are considered as complementary to, rather than as substitutes for, the Committee?s more complete and formal reports. Accordingly, if information from this document is utilized it is requested that this document not be listed as a reference. Individual reports dealing with most of the information presented at the Conference will subsequently be published by NACA and will therefore be suitable as reference material.

  15. Race horses vs work horses: Competition between the nuclear weapons labs in the 1950s

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Francis, S.

    1992-01-01

    This document provides a discussion of the missions and research programs of Los Alamos National Laboratory and Lawrence Livermore National Laboratory and details the competition between the two nuclear weapons laboratories in the 1950's. (FI)

  16. Race horses vs work horses: Competition between the nuclear weapons labs in the 1950s

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Francis, S.

    1992-06-01

    This document provides a discussion of the missions and research programs of Los Alamos National Laboratory and Lawrence Livermore National Laboratory and details the competition between the two nuclear weapons laboratories in the 1950`s. (FI)

  17. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  18. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  19. 40 CFR 262.214 - Laboratory management plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Waste Determination and Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain a... a site-specific document that describes how the eligible academic entity will manage unwanted...

  20. Sandia National Laboratories/New Mexico Environmental Information Document - Volume 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    BAYLISS, LINDA S.; GUERRERO, JOSEPH V.; JOHNS, WILLIAM H.

    This Sandia National Laboratories/New Mexico Environmental Information Document (EID) compiles information on the existing environment, or environmental baseline, for SNUNM. Much of the information is drawn from existing reports and databases supplemented by new research and data. The SNL/NM EID, together with the Sandia National Laboratories/New Mexico Facilities and Safety Information Document, provide a basis for assessing the environment, safety, and health aspects of operating selected facilities at SNL/NM. The environmental baseline provides a record of the existing physical, biological, and socioeconomic environment at SNL/NLM prior to being altered (beneficially or adversely) by proposed programs or projects. More specifically, themore » EID provides information on the following topics: Geology; Land Use; Hydrology and Water Resources; Air Quality and Meteorology; Ecology; Noise and Vibration; Cultural Resources; Visual Resources; Socioeconomic and Community Services; Transportation; Material Management; Waste Management; and Regulatory Requirements.« less

  1. Policies and practices pertaining to the selection, qualification requirements, and training programs for nuclear-reactor operating personnel at the Oak Ridge National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Culbert, W.H.

    1985-10-01

    This document describes the policies and practices of the Oak Ridge National Laboratory (ORNL) regarding the selection of and training requirements for reactor operating personnel at the Laboratory's nuclear-reactor facilities. The training programs, both for initial certification and for requalification, are described and provide the guidelines for ensuring that ORNL's research reactors are operated in a safe and reliable manner by qualified personnel. This document gives an overview of the reactor facilities and addresses the various qualifications, training, testing, and requalification requirements stipulated in DOE Order 5480.1A, Chapter VI (Safety of DOE-Owned Reactors); it is intended to be in compliancemore » with this DOE Order, as applicable to ORNL facilities. Included also are examples of the documentation maintained amenable for audit.« less

  2. Clinical protein mass spectrometry.

    PubMed

    Scherl, Alexander

    2015-06-15

    Quantitative protein analysis is routinely performed in clinical chemistry laboratories for diagnosis, therapeutic monitoring, and prognosis. Today, protein assays are mostly performed either with non-specific detection methods or immunoassays. Mass spectrometry (MS) is a very specific analytical method potentially very well suited for clinical laboratories. Its unique advantage relies in the high specificity of the detection. Any protein sequence variant, the presence of a post-translational modification or degradation will differ in mass and structure, and these differences will appear in the mass spectrum of the protein. On the other hand, protein MS is a relatively young technique, demanding specialized personnel and expensive instrumentation. Many scientists and opinion leaders predict MS to replace immunoassays for routine protein analysis, but there are only few protein MS applications routinely used in clinical chemistry laboratories today. The present review consists of a didactical introduction summarizing the pros and cons of MS assays compared to immunoassays, the different instrumentations, and various MS protein assays that have been proposed and/or are used in clinical laboratories. An important distinction is made between full length protein analysis (top-down method) and peptide analysis after enzymatic digestion of the proteins (bottom-up method) and its implication for the protein assay. The document ends with an outlook on what type of analyses could be used in the future, and for what type of applications MS has a clear advantage compared to immunoassays. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. High-resolution monitoring of marine protists based on an observation strategy integrating automated on-board filtration and molecular analyses

    NASA Astrophysics Data System (ADS)

    Metfies, Katja; Schroeder, Friedhelm; Hessel, Johanna; Wollschläger, Jochen; Micheller, Sebastian; Wolf, Christian; Kilias, Estelle; Sprong, Pim; Neuhaus, Stefan; Frickenhaus, Stephan; Petersen, Wilhelm

    2016-11-01

    Information on recent biomass distribution and biogeography of photosynthetic marine protists with adequate temporal and spatial resolution is urgently needed to better understand the consequences of environmental change for marine ecosystems. Here we introduce and review a molecular-based observation strategy for high-resolution assessment of these protists in space and time. It is the result of extensive technology developments, adaptations and evaluations which are documented in a number of different publications, and the results of the recently completed field testing which are introduced in this paper. The observation strategy is organized at four different levels. At level 1, samples are collected at high spatiotemporal resolution using the remotely controlled automated filtration system AUTOFIM. Resulting samples can either be preserved for later laboratory analyses, or directly subjected to molecular surveillance of key species aboard the ship via an automated biosensor system or quantitative polymerase chain reaction (level 2). Preserved samples are analyzed at the next observational levels in the laboratory (levels 3 and 4). At level 3 this involves molecular fingerprinting methods for a quick and reliable overview of differences in protist community composition. Finally, selected samples can be used to generate a detailed analysis of taxonomic protist composition via the latest next generation sequencing technology (NGS) at level 4. An overall integrated dataset of the results based on the different analyses provides comprehensive information on the diversity and biogeography of protists, including all related size classes. At the same time the cost of the observation is optimized with respect to analysis effort and time.

  4. Documenting the Physical Universe:Preserving the Record of SLAC from 1962 to 2005

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deken, Jean Marie; /SLAC

    2006-03-10

    Since 1905, Albert Einstein's ''miraculous year'', modern physics has advanced explosively. In 2005, the World Year of Physics, a session at the SAA Annual meeting discusses three institutional initiatives--Einstein's collected papers, an international geophysical program, and a research laboratory--to examine how physics and physicists are documented and how that documentation is being collected, preserved, and used. This paper provides a brief introduction to the research laboratory (SLAC), discusses the origins of the SLAC Archives and History Office, its present-day operations, and the present and future challenges it faces in attempting to preserve an accurate historical record of SLAC's activities.

  5. Analytical control test plan and microbiological methods for the water recovery test

    NASA Technical Reports Server (NTRS)

    Traweek, M. S. (Editor); Tatara, J. D. (Editor)

    1994-01-01

    Qualitative and quantitative laboratory results are important to the decision-making process. In some cases, they may represent the only basis for deciding between two or more given options or processes. Therefore, it is essential that handling of laboratory samples and analytical operations employed are performed at a deliberate level of conscientious effort. Reporting erroneous results can lead to faulty interpretations and result in misinformed decisions. This document provides analytical control specifications which will govern future test procedures related to all Water Recovery Test (WRT) Phase 3 activities to be conducted at the National Aeronautics and Space Administration/Marshall Space Flight Center (NASA/MSFC). This document addresses the process which will be used to verify analytical data generated throughout the test period, and to identify responsibilities of key personnel and participating laboratories, the chains of communication to be followed, and ensure that approved methodology and procedures are used during WRT activities. This document does not outline specifics, but provides a minimum guideline by which sampling protocols, analysis methodologies, test site operations, and laboratory operations should be developed.

  6. Phase 1 environmental report for the Advanced Neutron Source at Oak Ridge National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blasing, T.J.; Brown, R.A.; Cada, G.F.

    1992-02-01

    The US Department of Energy (DOE) has proposed the construction and operation of the Advanced Neutron Source (ANS), a 330-MW(f) reactor, at Oak Ridge National Laboratory (ORNL) to support neutron scattering and nuclear physics experiments. ANS would provide a steady-state source of neutrons that are thermalized to produce sources of hot, cold, and very coal neutrons. The use of these neutrons in ANS experiment facilities would be an essential component of national research efforts in basic materials science. Additionally, ANS capabilities would include production of transplutonium isotopes, irradiation of potential fusion and fission reactor materials, activation analysis, and production ofmore » medical and industrial isotopes such as {sup 252}Cf. Although ANS would not require licensing by the US Nuclear Regulatory Commission (NRC), DOE regards the design, construction, and operation of ANS as activities that would produce a licensable facility; that is, DOE is following the regulatory guidelines that NRC would apply if NRC were licensing the facility. Those guidelines include instructions for the preparation of an environmental report (ER), a compilation of available data and preliminary analyses regarding the environmental impacts of nuclear facility construction and operation. The ER, described and outlined in NRC Regulatory Guide 4.2, serves as a background document to facilitate the preparation of environmental impact statements (EISs). Using Regulatory Guide 4.2 as a model, this ANS ER provides analyses and information specific to the ANS site and area that can be adopted (and modified, if necessary) for the ANS EIS. The ER is being prepared in two phases. Phase 1 ER includes many of the data and analyses needed to prepare the EIS but does not include data or analyses of alternate sites or alternate technologies. Phase 2 ER will include the additional data and analyses stipulated by Regulatory Guide 4.2.« less

  7. Development of a competency based training programme to support multidisciplinary working in a combined biochemistry/haematology laboratory

    PubMed Central

    Woods, R; Longmire, W; Galloway, M; Smellie, W

    2000-01-01

    The aim of this study was to develop a competency based training programme to support multidisciplinary working in a combined biochemistry and haematology laboratory. The training programme was developed to document that staff were trained in the full range of laboratory tests that they were expected to perform. This programme subsequently formed the basis for the annual performance review of all staff. All staff successfully completed the first phase of the programme. This allowed laboratory staff to work unsupervised at night as part of a partial shift system. All staff are now working towards achieving a level of competence equivalent to the training level required for state registration by the Council for Professions Supplementary to Medicine. External evaluation of the training programme has included accreditation by the Council for Professions Supplementary to Medicine and reinspection by Clinical Pathology Accreditation (UK) Ltd. The development of a competency based training system has facilitated the introduction of multidisciplinary working in the laboratory. In addition, it enables the documentation of all staff to ensure that they are fully trained and are keeping up to date, because the continuing professional development programme in use in our laboratory has been linked to this training scheme. This approach to documentation of training facilitated a recent reinspection by Clinical Pathology Accreditation (UK) Ltd. Key Words: Keyword: multidisciplinary working • competency based training PMID:10889827

  8. Environmental Response Laboratory Network (ERLN) Data Submission Requirements

    EPA Pesticide Factsheets

    These Environmental Response Laboratory Network specifications are essential to the mission of providing consistent analytical data of know and documented quality for each Analytical Service Request (ASR).

  9. Indoor Air Vapor Intrusion Mitigation Approaches

    EPA Pesticide Factsheets

    The National Risk Management Research Laboratory has developed a technology transfer document regarding management and treatment of vapor intrusion into building structures. This document describes the range of mitigation technologies available.

  10. Reduction of Hazardous Waste from High School Chemistry Laboratories.

    ERIC Educational Resources Information Center

    Wahl, George H., Jr., Ed.

    This document provides teachers with sources of useful information and new ideas about the high school chemistry laboratory program. Chapters included are: (1) "Introduction" describing the philosophy and specific objectives of this project; (2) "Importance of Laboratory Work"; (3) "Chemistry Lab Outline" listing…

  11. 21 CFR 58.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.195 Retention of records. (a..., documentation records, raw data and specimens pertaining to a nonclinical laboratory study and required to be...

  12. Photographic Documentation of Emerald Spreadwing at TA-3, LANL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Foy, Bernard R.

    2017-06-20

    Los Alamos National Laboratory has a considerable amount of suitable habitat for odonates, or dragonflies and damselflies. Few of these have been properly documented, however. With photographic documentation, the quality and size of odonate habitat on land owned by the Department of Energy will become more apparent to land managers.

  13. Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin

    PubMed Central

    Vedula, S. Swaroop; Li, Tianjing; Dickersin, Kay

    2013-01-01

    Background Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our objective was to compare the description of types of analyses and criteria for including participants in the publication (i.e., what was reported) with descriptions in the corresponding internal company documents (i.e., what was planned and what was done). Trials were for off-label uses of gabapentin sponsored by Pfizer and Parke-Davis, and documents were obtained through litigation. Methods and Findings For each trial, we compared internal company documents (protocols, statistical analysis plans, and research reports, all unpublished), with publications. One author extracted data and another verified, with a third person verifying discordant items and a sample of the rest. Extracted data included the number of participants randomized and analyzed for efficacy, and types of analyses for efficacy and safety and their definitions (i.e., criteria for including participants in each type of analysis). We identified 21 trials, 11 of which were published randomized controlled trials, and that provided the documents needed for planned comparisons. For three trials, there was disagreement on the number of randomized participants between the research report and publication. Seven types of efficacy analyses were described in the protocols, statistical analysis plans, and publications, including ITT and six others. The protocol or publication described ITT using six different definitions, resulting in frequent disagreements between the two documents (i.e., different numbers of participants were included in the analyses). Conclusions Descriptions of analyses conducted did not agree between internal company documents and what was publicly reported. Internal company documents provide extensive documentation of methods planned and used, and trial findings, and should be publicly accessible. Reporting standards for randomized controlled trials should recommend transparent descriptions and definitions of analyses performed and which study participants are excluded. Please see later in the article for the Editors' Summary PMID:23382656

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    White Oak Dam is located in the White Oak Creek watershed which provides the primary surface drainage for Oak Ridge National Laboratory. A stability analysis was made on the dam by Syed Ahmed in January 1994 which included an evaluation of the liquefaction potential of the embankment and foundation. This report evaluates the stability of the dam and includes comments on the report prepared by Ahmed. Slope stability analyses were performed on the dam and included cases for sudden drawdown, steady seepage, partial pool and earthquake. Results of the stability analyses indicate that the dam is stable and failure ofmore » the structure would not occur for the cases considered. The report prepared by Ahmed leads to the same conclusions as stated above. Review of the report finds that it is complete, well documented and conservative in its selection of soil parameters. The evaluation of the liquefaction potential is also complete and this report is in agreement with the findings that the dam and foundation are not susceptible to liquefaction.« less

  15. Physical Property Analysis and Report for Sediments at 100-BC-5 Operable Unit, Boreholes C7505, C7506, C7507, and C7665

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lindberg, Michael J.

    2010-09-28

    Between October 14, 2009 and February 22, 2010 sediment samples were received from 100-BC Decision Unit for geochemical studies. This is an analytical data report for sediments received from CHPRC at the 100 BC 5 OU. The analyses for this project were performed at the 325 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibrationmore » requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.« less

  16. Noble gas isotopes in mineral springs and wells within the Cascadia forearc, Washington, Oregon, and California

    USGS Publications Warehouse

    McCrory, Patricia A.; Constantz, James E.; Hunt, Andrew G.

    2017-01-31

    IntroductionThis U.S. Geological Survey report presents laboratory analyses along with field notes for an exploratory study to document the relative abundance of noble gases in mineral springs and water wells within the Cascadia forearc of Washington, Oregon, and California (fig. 1). This report describes 14 samples collected in 2014 and 2015 and complements a previous report that describes 9 samples collected in 2012 and 2013 (McCrory and others, 2014b). Estimates of the depth to the underlying Juan de Fuca oceanic plate beneath sample sites are derived from the McCrory and others (2012) slab model. Some of the springs have been previously sampled for chemical analyses (Mariner and others, 2006), but none of the springs or wells currently has publicly available noble gas data. The helium and neon isotope values and ratios presented below are used to determine the sources and mixing history of these mineral and well waters (for example, McCrory and others, 2016).

  17. Information Quality in Regulatory Decision Making: Peer Review versus Good Laboratory Practice.

    PubMed

    McCarty, Lynn S; Borgert, Christopher J; Mihaich, Ellen M

    2012-07-01

    There is an ongoing discussion on the provenance of toxicity testing data regarding how best to ensure its validity and credibility. A central argument is whether journal peer-review procedures are superior to Good Laboratory Practice (GLP) standards employed for compliance with regulatory mandates. We sought to evaluate the rationale for regulatory decision making based on peer-review procedures versus GLP standards. We examined pertinent published literature regarding how scientific data quality and validity are evaluated for peer review, GLP compliance, and development of regulations. Some contend that peer review is a coherent, consistent evaluative procedure providing quality control for experimental data generation, analysis, and reporting sufficient to reliably establish relative merit, whereas GLP is seen as merely a tracking process designed to thwart investigator corruption. This view is not supported by published analyses pointing to subjectivity and variability in peer-review processes. Although GLP is not designed to establish relative merit, it is an internationally accepted quality assurance, quality control method for documenting experimental conduct and data. Neither process is completely sufficient for establishing relative scientific soundness. However, changes occurring both in peer-review processes and in regulatory guidance resulting in clearer, more transparent communication of scientific information point to an emerging convergence in ensuring information quality. The solution to determining relative merit lies in developing a well-documented, generally accepted weight-of-evidence scheme to evaluate both peer-reviewed and GLP information used in regulatory decision making where both merit and specific relevance inform the process.

  18. 75 FR 17281 - Changes in Hourly Fee Rates for Science and Technology Laboratory Services-Fiscal Years 2010-2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ..., residue chemistry, proximate analysis for composition, and biomolecular (DNA-based) testing. A user fee... provide greater clarity of reported test analyses and laboratory determinations. DATES: Effective April 7... analyses and laboratory determinations provided by AMS laboratory services apply only to the submitted...

  19. Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory.

    PubMed

    Wang, Qin; Zhou, Wei-Min; Zhang, Yong; Wang, Huan-Yu; Du, Hai-Jun; Nie, Kai; Song, Jing-Dong; Xiao, Kang; Lei, Wen-Wen; Guo, Jian-Qiang; Wei, He-Jiang; Cai, Kun; Wang, Yan-Hai; Wu, Jiang; Kamara, Gerard; Kamara, Idrissa; Wei, Qiang; Liang, Mi-Fang; Wu, Gui-Zhen; Dong, Xiao-Ping

    2016-06-23

    The outbreak of Ebola virus disease (EVD) in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus (EBOV) in 1976, and the countries most strongly affected were Sierra Leone, Guinea, and Liberia. The Sierra Leone-China Friendship Biological Safety Laboratory (SLE-CHN Biosafety Lab), a fixed Biosafety Level 3 laboratory in the capital city of Sierra Leone, was established by the Chinese government and has been active in EBOV detection since 11 March 2015. Complete management and program documents were created for the SLE-CHN Biosafety Lab, and it was divided into four zones (the green, yellow, brown, and red zones) based on the risk assessment. Different types of safe and appropriate personnel protection equipment (PPE) are used in different zones of the laboratory, and it fully meets the Biosafety Level 3 laboratory standards of the World Health Organization. Good preparedness, comprehensive risk assessment and operation documents, appropriate PPE, effective monitoring and intensive training, together with well-designed and reasonable laboratory sectioning are essential for guaranteeing biosafety.

  20. Dental Laboratory Technician.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center on Education and Training for Employment.

    This document, which is designed for use in developing a tech prep competency profile for the occupation of dental laboratory technician, lists technical competencies and competency builders for 13 units pertinent to the health technologies cluster in general and 8 units to the occupation of dental laboratory technician. The following skill areas…

  1. Medical Laboratory Technician.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center on Education and Training for Employment.

    This document, which is designed for use in developing a tech prep competency profile for the occupation of medical laboratory technician, lists technical competencies and competency builders for 18 units pertinent to the health technologies cluster in general and 8 units specific to the occupation of medical laboratory technician. The following…

  2. Conceptual design of the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Paisner, Jeffrey A.; Boyes, John D.; Kumpan, Steven A.; Lowdermilk, W. Howard; Sorem, Michael S.

    1995-12-01

    The Secretary of the U.S. Department of Energy (DOE) commissioned a conceptual design report (CDR) for the National Ignition Facility (NIF) in January 1993 as part of a key decision zero (KD0), justification of mission need. Motivated by the progress to date by the inertial confinement fusion (ICF) program in meeting the Nova technical contract goals established by the National Academy of Sciences in 1989, the Secretary requested a design using a solid-state laser driver operating at the third harmonic (0.35 micrometer) of neodymium (Nd) glass. The participating ICF laboratories signed a memorandum of agreement in August 1993, and established a project organization, including a technical team from the Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Sandia National Laboratories (SNL), and the Laboratory for Laser Energetics at the University of Rochester. Since then, we completed the NIF conceptual design, based on standard construction at a generic DOE defense program's site, and issued a 7,000-page, 27-volume CDR in May 1994. Over the course of the conceptual design study, several other key documents were generated, including a facilities requirements document, a conceptual design scope and plan, a target physics design document, a laser design cost basis document, a functional requirements document, an experimental plan for indirect drive ignition, and a preliminary hazards analysis (PHA) document. DOE used the PHA to categorize the NIF as a low-hazard, non-nuclear facility. On October 21, 1994 the Secretary of Energy issued a key decision one (KD1) for the NIF, which approved the project and authorized DOE to request Office of Management and Budget-approval for congressional line-item FY 1996 NIF funding for preliminary engineering design and for National Environmental Policy Act activities. In addition, the Secretary declared Livermore as the preferred site for constructing the NIF. In February 1995, the NIF Project was formally submitted to Congress as part of the President's FY 1996 budget. If funded as planned, the Project will cost approximately $1.1 billion and will be completed at the end of FY 2002.

  3. 6 CFR 37.15 - Physical security features for the driver's license or identification card.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... (3) Level 3. Inspection by forensic specialists. (d) Document security and integrity. States must... independent laboratory experienced with adversarial analysis of identification documents concerning one or...

  4. 6 CFR 37.15 - Physical security features for the driver's license or identification card.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... (3) Level 3. Inspection by forensic specialists. (d) Document security and integrity. States must... independent laboratory experienced with adversarial analysis of identification documents concerning one or...

  5. 6 CFR 37.15 - Physical security features for the driver's license or identification card.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... (3) Level 3. Inspection by forensic specialists. (d) Document security and integrity. States must... independent laboratory experienced with adversarial analysis of identification documents concerning one or...

  6. 6 CFR 37.15 - Physical security features for the driver's license or identification card.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... (3) Level 3. Inspection by forensic specialists. (d) Document security and integrity. States must... independent laboratory experienced with adversarial analysis of identification documents concerning one or...

  7. SUPPLEMENTAL ANALYSES FOR SOLVENT HOLD TANK SAMPLES MCU-11-314, MCU-11-315, MCU-11-316, MCU-11-317, MCU-11-318 AND MCU-11-319

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T.; Washington, A; . Fondeur, F.

    2011-09-29

    Savannah River National Laboratory (SRNL) periodically analyses solvent samples from Modular Caustic-Side Solvent Extraction Unit (MCU) in support of continuing operations. A quarterly analysis of the solvent is required to maintain solvent composition within specifications. Analytical results of the analyses of Solvent Hold Tank (SHT) samples MCU-11-314, MCU-11-315, MCU-11-316, MCU-11-317, MCU-11-318 and MCU-11-319 have been previously reported. MCU has experienced a modest decline in cesium removal efficiency while processing the current feed, 'Macrobatch 3'. While the target decontamination factor (DF) is 200, the fiscal year 2011 DF average is 161. The results of the prior solvent analysis report did notmore » identify a specific factor that would correlate with the poor cesium decontamination beyond a low concentration of the suppressor, trioctylamine. New analyses of the quarterly sample are reported in this document, as well as a cross-check of {sup 137}Cs measurements for SRNL and F/H lab. Furthermore, in an attempt to discover the reason for the decline in DF at MCU, SRNL was tasked with analyzing numerous Caustic Wash Tank (CWT) and chemical feed samples.« less

  8. 78 FR 15746 - Compendium of Analyses To Investigate Select Level 1 Probabilistic Risk Assessment End-State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0047] Compendium of Analyses To Investigate Select Level 1...) has issued for public comment a document entitled: Compendium of Analyses to Investigate Select Level... begin the search, select ``ADAMS Public Documents'' and then select ``Begin Web- based ADAMS Search...

  9. TREAT Transient Analysis Benchmarking for the HEU Core

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kontogeorgakos, D. C.; Connaway, H. M.; Wright, A. E.

    2014-05-01

    This work was performed to support the feasibility study on the potential conversion of the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory from the use of high enriched uranium (HEU) fuel to the use of low enriched uranium (LEU) fuel. The analyses were performed by the GTRI Reactor Conversion staff at the Argonne National Laboratory (ANL). The objective of this study was to benchmark the transient calculations against temperature-limited transients performed in the final operating HEU TREAT core configuration. The MCNP code was used to evaluate steady-state neutronics behavior, and the point kinetics code TREKIN was used tomore » determine core power and energy during transients. The first part of the benchmarking process was to calculate with MCNP all the neutronic parameters required by TREKIN to simulate the transients: the transient rod-bank worth, the prompt neutron generation lifetime, the temperature reactivity feedback as a function of total core energy, and the core-average temperature and peak temperature as a functions of total core energy. The results of these calculations were compared against measurements or against reported values as documented in the available TREAT reports. The heating of the fuel was simulated as an adiabatic process. The reported values were extracted from ANL reports, intra-laboratory memos and experiment logsheets and in some cases it was not clear if the values were based on measurements, on calculations or a combination of both. Therefore, it was decided to use the term “reported” values when referring to such data. The methods and results from the HEU core transient analyses will be used for the potential LEU core configurations to predict the converted (LEU) core’s performance.« less

  10. LANGUAGE LABORATORY SPECIFICATIONS. A PROCUREMENT GUIDE FOR THE PURCHASE OF LANGUAGE LABORATORY INSTALLATIONS IN WISCONSIN, NDEA, TITLE III.

    ERIC Educational Resources Information Center

    GRITTNER, FRANK; PAVLAT, RUSSELL

    THE KNOWLEDGE ACCUMULATED FROM THE EXPERIENCE OF INSTALLING MANY LANGUAGE LABORATORIES UNDER THE TITLE III, NDEA PROGRAM FORMS THE BASIS FOR THE GUIDELINES PRESENTED IN THIS BULLETIN. THE DOCUMENT INCLUDES A SUMMARY OF CONDITIONS DESIRABLE PRIOR TO THE PURCHASE OF A LABORATORY, SAMPLE SPECIFICATIONS FOR EACH COMPONENT OF THE LAB, SPECIFICATIONS…

  11. Whole Class Laboratories: More Examples

    ERIC Educational Resources Information Center

    Kouh, Minjoon

    2016-01-01

    Typically, introductory physics courses are taught with a combination of lectures and laboratories in which students have opportunities to discover the natural laws through hands-on activities in small groups. This article reports the use of Google Drive, a free online document-sharing tool, in physics laboratories for pooling experimental data…

  12. Basic Laboratory Skills. Training Module 5.300.2.77.

    ERIC Educational Resources Information Center

    Kirkwood Community Coll., Cedar Rapids, IA.

    This document is an instructional module package prepared in objective form for use by an instructor familiar with the basic chemical and microbiological laboratory equipment and procedures used in water and wastewater treatment plant laboratories. Included are objectives, instructor guides, student handouts and transparency masters. This module…

  13. Consumer-Oriented Laboratory Activities: A Manual for Secondary Science Students.

    ERIC Educational Resources Information Center

    Anderson, Jacqueline; McDuffie, Thomas E., Jr.

    This document provides a laboratory manual for use by secondary level students in performing consumer-oriented laboratory experiments. Each experiment includes an introductory question outlining the purpose of the investigation, a detailed discussion, detailed procedures, questions to be answered upon completing the experiment, and information for…

  14. Laboratory evaluation of detectors of explosives' effluents

    DOT National Transportation Integrated Search

    1972-11-30

    This document contains the classification, technical description and laboratory evaluation of five commercial detectors for explosives' effluents. It includes an outline of operating principles, test and evaluation procedures. The evaluation is based...

  15. Document Classification in Support of Automated Metadata Extraction Form Heterogeneous Collections

    ERIC Educational Resources Information Center

    Flynn, Paul K.

    2014-01-01

    A number of federal agencies, universities, laboratories, and companies are placing their documents online and making them searchable via metadata fields such as author, title, and publishing organization. To enable this, every document in the collection must be catalogued using the metadata fields. Though time consuming, the task of identifying…

  16. Management of technical date in Nihon Doro kodan

    NASA Astrophysics Data System (ADS)

    Hanada, Jun'ichi

    Nihon Doro Kodan Laboratory has collected and contributed technical data (microfiches, aerial photographs, books and literature) on plans, designs, constructions and maintenance of the national expressways and the ordinary toll roads since 1968. This work is systematized on computer to retrieve and contribute data faster. Now Laboratory operates Technical Data Management System which manages all of technical data and Technical Document Management System which manages technical documents. These systems stand on users' on-line retrieval and data accumuration by microfiches and optical disks.

  17. Idaho National Engineering Laboratory Waste Management Operations Roadmap Document

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bullock, M.

    1992-04-01

    At the direction of the Department of Energy-Headquarters (DOE-HQ), the DOE Idaho Field Office (DOE-ID) is developing roadmaps for Environmental Restoration and Waste Management (ER&WM) activities at Idaho National Engineering Laboratory (INEL). DOE-ID has convened a select group of contractor personnel from EG&G Idaho, Inc. to assist DOE-ID personnel with the roadmapping project. This document is a report on the initial stages of the first phase of the INEL`s roadmapping efforts.

  18. In vitro susceptibility of filamentous fungi to itraconazole, voriconazole and posaconazole by Clinical and Laboratory Standards Institute reference method and E-test.

    PubMed

    Kondori, N; Svensson, E; Mattsby-Baltzer, I

    2011-09-01

    The use of anti-fungal agents has increased dramatically in recent years and new drugs have been developed. Several methods are available for determinations of their specific biological activities, i.e. the standard method for minimum inhibitory concentration-determination is described in M-38 [Clinical and Laboratory Standards Institute document M-38 (CLSI M-38)]. However, alternative methods, such as the E-test, are currently available in Mycology laboratories. The susceptibilities of clinical isolates of Aspergillus spp. (n = 29), Fusarium spp. (n = 5), zygomycetes (n = 21) and Schizophyllum (n = 1) were determined for itraconazole, voriconazole and posaconazole, using the CLSI M-38-A broth dilution method and also by the E-test. A good overall agreement (83.7%) between the two methods for all drugs and organisms was observed. Analyses of voriconazole showed a better agreement (93%) between the methods than posaconazole and itraconazole (85% and 74% respectively). Aspergillus spp. were the most susceptible fungi to the anti-fungal agents tested in this study. Posaconazole was the most active drug against filamentous fungi in vitro, followed by itraconazole and voriconazole. The latter (voriconazole) demonstrated no significant in vitro activity against zygomycetes. © 2010 Blackwell Verlag GmbH.

  19. BioVeL: a virtual laboratory for data analysis and modelling in biodiversity science and ecology.

    PubMed

    Hardisty, Alex R; Bacall, Finn; Beard, Niall; Balcázar-Vargas, Maria-Paula; Balech, Bachir; Barcza, Zoltán; Bourlat, Sarah J; De Giovanni, Renato; de Jong, Yde; De Leo, Francesca; Dobor, Laura; Donvito, Giacinto; Fellows, Donal; Guerra, Antonio Fernandez; Ferreira, Nuno; Fetyukova, Yuliya; Fosso, Bruno; Giddy, Jonathan; Goble, Carole; Güntsch, Anton; Haines, Robert; Ernst, Vera Hernández; Hettling, Hannes; Hidy, Dóra; Horváth, Ferenc; Ittzés, Dóra; Ittzés, Péter; Jones, Andrew; Kottmann, Renzo; Kulawik, Robert; Leidenberger, Sonja; Lyytikäinen-Saarenmaa, Päivi; Mathew, Cherian; Morrison, Norman; Nenadic, Aleksandra; de la Hidalga, Abraham Nieva; Obst, Matthias; Oostermeijer, Gerard; Paymal, Elisabeth; Pesole, Graziano; Pinto, Salvatore; Poigné, Axel; Fernandez, Francisco Quevedo; Santamaria, Monica; Saarenmaa, Hannu; Sipos, Gergely; Sylla, Karl-Heinz; Tähtinen, Marko; Vicario, Saverio; Vos, Rutger Aldo; Williams, Alan R; Yilmaz, Pelin

    2016-10-20

    Making forecasts about biodiversity and giving support to policy relies increasingly on large collections of data held electronically, and on substantial computational capability and capacity to analyse, model, simulate and predict using such data. However, the physically distributed nature of data resources and of expertise in advanced analytical tools creates many challenges for the modern scientist. Across the wider biological sciences, presenting such capabilities on the Internet (as "Web services") and using scientific workflow systems to compose them for particular tasks is a practical way to carry out robust "in silico" science. However, use of this approach in biodiversity science and ecology has thus far been quite limited. BioVeL is a virtual laboratory for data analysis and modelling in biodiversity science and ecology, freely accessible via the Internet. BioVeL includes functions for accessing and analysing data through curated Web services; for performing complex in silico analysis through exposure of R programs, workflows, and batch processing functions; for on-line collaboration through sharing of workflows and workflow runs; for experiment documentation through reproducibility and repeatability; and for computational support via seamless connections to supporting computing infrastructures. We developed and improved more than 60 Web services with significant potential in many different kinds of data analysis and modelling tasks. We composed reusable workflows using these Web services, also incorporating R programs. Deploying these tools into an easy-to-use and accessible 'virtual laboratory', free via the Internet, we applied the workflows in several diverse case studies. We opened the virtual laboratory for public use and through a programme of external engagement we actively encouraged scientists and third party application and tool developers to try out the services and contribute to the activity. Our work shows we can deliver an operational, scalable and flexible Internet-based virtual laboratory to meet new demands for data processing and analysis in biodiversity science and ecology. In particular, we have successfully integrated existing and popular tools and practices from different scientific disciplines to be used in biodiversity and ecological research.

  20. Cielo Computational Environment Usage Model With Mappings to ACE Requirements for the General Availability User Environment Capabilities Release Version 1.1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vigil,Benny Manuel; Ballance, Robert; Haskell, Karen

    Cielo is a massively parallel supercomputer funded by the DOE/NNSA Advanced Simulation and Computing (ASC) program, and operated by the Alliance for Computing at Extreme Scale (ACES), a partnership between Los Alamos National Laboratory (LANL) and Sandia National Laboratories (SNL). The primary Cielo compute platform is physically located at Los Alamos National Laboratory. This Cielo Computational Environment Usage Model documents the capabilities and the environment to be provided for the Q1 FY12 Level 2 Cielo Capability Computing (CCC) Platform Production Readiness Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model ismore » focused on the needs of the ASC user working in the secure computing environments at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory, or Sandia National Laboratories, but also addresses the needs of users working in the unclassified environment. The Cielo Computational Environment Usage Model maps the provided capabilities to the tri-Lab ASC Computing Environment (ACE) Version 8.0 requirements. The ACE requirements reflect the high performance computing requirements for the Production Readiness Milestone user environment capabilities of the ASC community. A description of ACE requirements met, and those requirements that are not met, are included in each section of this document. The Cielo Computing Environment, along with the ACE mappings, has been issued and reviewed throughout the tri-Lab community.« less

  1. Interlaboratory comparability, bias, and precision for four laboratories measuring analytes in wet deposition, October 1983-December 1984

    USGS Publications Warehouse

    Brooks, Myron H.; Schroder, LeRoy J.; Willoughby, Timothy C.

    1987-01-01

    Four laboratories involved in the routine analysis of wet-deposition samples participated in an interlaboratory comparison program managed by the U.S. Geological Survey. The four participants were: Illinois State Water Survey central analytical laboratory in Champaign, Illinois; U.S. Geological Survey national water-quality laboratories in Atlanta, Georgia, and Denver, Colorado; and Inland Waters Directorate national water-quality laboratory in Burlington, Ontario, Canada. Analyses of interlaboratory samples performed by the four laboratories from October 1983 through December 1984 were compared.Participating laboratories analyzed three types of interlaboratory samples--natural wet deposition, simulated wet deposition, and deionized water--for pH and specific conductance, and for dissolved calcium, magnesium, sodium, sodium, potassium, chloride, sulfate, nitrate, ammonium, and orthophosphate. Natural wet-deposition samples were aliquots of actual wet-deposition samples. Analyses of these samples by the four laboratories were compared using analysis of variance. Test results indicated that pH, calcium, nitrate, and ammonium results were not directly comparable among the four laboratories. Statistically significant differences between laboratory results probably only were meaningful for analyses of dissolved calcium. Simulated wet-deposition samples with known analyte concentrations were used to test each laboratory for analyte bias. Laboratory analyses of calcium, magnesium, sodium, potassium, chloride, sulfate, and nitrate were not significantly different from the known concentrations of these analytes when tested using analysis of variance. Deionized-water samples were used to test each laboratory for reporting of false positive values. The Illinois State Water Survey Laboratory reported the smallest percentage of false positive values for most analytes. Analyte precision was estimated for each laboratory from results of replicate measurements. In general, the Illinois State Water Survey laboratory achieved the greatest precision, whereas the U.S. Geological Survey laboratories achieved the least precision.

  2. The UK Earth System Models Marine Biogeochemical Evaluation Toolkit, BGC-val

    NASA Astrophysics Data System (ADS)

    de Mora, Lee

    2017-04-01

    The Biogeochemical Validation toolkit, BGC-val, is a model and grid independent python-based marine model evaluation framework that automates much of the validation of the marine component of an Earth System Model. BGC-val was initially developed to be a flexible and extensible system to evaluate the spin up of the marine UK Earth System Model (UKESM). However, the grid-independence and flexibility means that it is straightforward to adapt the BGC-val framework to evaluate other marine models. In addition to the marine component of the UKESM, this toolkit has been adapted to compare multiple models, including models from the CMIP5 and iMarNet inter-comparison projects. The BGC-val toolkit produces multiple levels of analysis which are presented in a simple to use interactive html5 document. Level 1 contains time series analyses, showing the development over time of many important biogeochemical and physical ocean metrics, such as the Global primary production or the Drake passage current. The second level of BGC-val is an in-depth spatial analyses of a single point in time. This is a series of point to point comparison of model and data in various regions, such as a comparison of Surface Nitrate in the model vs data from the world ocean atlas. The third level analyses are specialised ad-hoc packages to go in-depth on a specific question, such as the development of Oxygen minimum zones in the Equatorial Pacific. In additional to the three levels, the html5 document opens with a Level 0 table showing a summary of the status of the model run. The beta version of this toolkit is available via the Plymouth Marine Laboratory Gitlab server and uses the BSD 3 clause license.

  3. Strategic establishment of an International Pharmacology Specialty Laboratory in a resource-limited setting.

    PubMed

    Mtisi, Takudzwa J; Maponga, Charles; Monera-Penduka, Tsitsi G; Mudzviti, Tinashe; Chagwena, Dexter; Makita-Chingombe, Faithful; DiFranchesco, Robin; Morse, Gene D

    2018-01-01

    A growing number of drug development studies that include pharmacokinetic evaluations are conducted in regions lacking a specialised pharmacology laboratory. This necessitated the development of an International Pharmacology Specialty Laboratory (IPSL) in Zimbabwe. The aim of this article is to describe the development of an IPSL in Zimbabwe. The IPSL was developed collaboratively by the University of Zimbabwe and the University at Buffalo Center for Integrated Global Biomedical Sciences. Key stages included infrastructure development, establishment of quality management systems and collaborative mentorship in clinical pharmacology study design and chromatographic assay development and validation. Two high performance liquid chromatography instruments were donated by an instrument manufacturer and a contract research organisation. Laboratory space was acquired through association with the Zimbabwe national drug regulatory authority. Operational policies, standard operating procedures and a document control system were established. Scientists and technicians were trained in aspects relevant to IPSL operations. A high-performance liquid chromatography method for nevirapine was developed with the guidance of the Clinical Pharmacology Quality Assurance programme and approved by the assay method review programme. The University of Zimbabwe IPSL is engaged with the United States National Institute of Allergy and Infectious Diseases Division of AIDS research networks and is poised to begin drug assays and pharmacokinetic analyses. An IPSL has been successfully established in a resource-limited setting through the efforts of an external partnership providing technical guidance and motivated internal faculty and staff. Strategic partnerships were beneficial in navigating challenges leading to laboratory development and training new investigators. The IPSL is now engaged in clinical pharmacology research.

  4. The importance of having a flexible scope ISO 15189 accreditation and quality specifications based on biological variation--the case of validation of the biochemistry analyzer Dimension Vista.

    PubMed

    Fernandez-Calle, Pilar; Pelaz, Sandra; Oliver, Paloma; Alcaide, Maria Jose; Gomez-Rioja, Ruben; Buno, Antonio; Iturzaeta, Jose Manuel

    2013-01-01

    Technological innovation requires the laboratories to ensure that modifications or incorporations of new techniques do not alter the quality of their results. In an ISO 15189 accredited laboratory, flexible scope accreditation facilitates the inclusion of these changes prior to accreditation body evaluation. A strategy to perform the validation of a biochemistry analyzer in an accredited laboratory having a flexible scope is shown. A validation procedure including the evaluation of imprecision and bias of two Dimension Vista analysers 1500 was conducted. Comparability of patient results between one of them and the lately replaced Dimension RxL Max was evaluated. All studies followed the respective Clinical and Laboratory Standards Institute (CLSI) protocols. 30 chemistry assays were studied. Coefficients of variation, percent bias and total error were calculated for all tests and biological variation was considered as acceptance criteria. Quality control material and patient samples were used as test materials. Interchangeability of the results was established by processing forty patients' samples in both devices. 27 of the 30 studied parameters met allowable performance criteria. Sodium, chloride and magnesium did not fulfil acceptance criteria. Evidence of interchangeability of patient results was obtained for all parameters except magnesium, NT-proBNP, cTroponin I and C-reactive protein. A laboratory having a well structured and documented validation procedure can opt to get a flexible scope of accreditation. In addition, performing these activities prior to use on patient samples may evidence technical issues which must be corrected to minimize their impact on patient results.

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lundergan, C. D.; Mead, P. L.

    This report is a compilation of 17 individual documents that together summarize the technical capabilities of Sandia Laboratories. Each document in this compilation contains details about a specific area of capability. Examples of application of the capability to research and development problems are provided. An eighteenth document summarizes the content of the other seventeen. Each of these documents was issued with a separate report number (SAND 74-0073A through SAND 74-0091, except -0078). (RWR)

  6. Survey of Forensic Document Examination Habit Areas: Degree of Use and Discriminatory Power

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G Sperry; PA Manzolillo; RC Hanlan

    Beginning in 1998, the Pacific Northwest National Laboratory (PNL), US Postal Inspection Service Forensic Laboratory (USPIS), and the Data Fusion Laboratory, Drexel University (DFL) have been collaborating on a large scale research project ''Handwriting Individuality--Moving From Art to Science''. In April 1998 a survey was distributed to the community of forensic document examiners (FDEs) requesting input on the habit areas used and their utility in distinguishing handwriting. The information obtained from this survey was intended to provide the data necessary to select the criteria and begin the evaluation of the handwriting samples currently in the project. Preliminary results of themore » survey were made available to the community at the American Society of Questioned Document Examiners (ASQDE) meeting in August 1998 and the American Academy of Forensic Sciences (AAFS) meeting in February 1999. This report provides final documentation of the survey and its results. This survey has two objectives: (1) to compile a list of handwriting features and characteristics used by professional forensic document examiners in the examination and comparison of handwriting and (2) to gather information about the significance of these features and characteristics. These objectives are met by having the FDEs provide an indication of their experience in the frequency of habit area evaluation and the utility of the habit area for discrimination.« less

  7. DATA QUALITY OBJECTIVES FOR SELECTING WASTE SAMPLES FOR BENCH-SCALE REFORMER TREATABILITY STUDIES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    BANNING DL

    2011-02-11

    This document describes the data quality objectives to select archived samples located at the 222-S Laboratory for Bench-Scale Reforming testing. The type, quantity, and quality of the data required to select the samples for Fluid Bed Steam Reformer testing are discussed. In order to maximize the efficiency and minimize the time to treat Hanford tank waste in the Waste Treatment and Immobilization Plant, additional treatment processes may be required. One of the potential treatment processes is the fluidized bed steam reformer. A determination of the adequacy of the fluidized bed steam reformer process to treat Hanford tank waste is required.more » The initial step in determining the adequacy of the fluidized bed steam reformer process is to select archived waste samples from the 222-S Laboratory that will be used in a bench scale tests. Analyses of the selected samples will be required to confirm the samples meet the shipping requirements and for comparison to the bench scale reformer (BSR) test sample selection requirements.« less

  8. Enhanced verification test suite for physics simulation codes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamm, James R.; Brock, Jerry S.; Brandon, Scott T.

    2008-09-01

    This document discusses problems with which to augment, in quantity and in quality, the existing tri-laboratory suite of verification problems used by Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratories (SNL). The purpose of verification analysis is demonstrate whether the numerical results of the discretization algorithms in physics and engineering simulation codes provide correct solutions of the corresponding continuum equations.

  9. Electric Vehicle and Wireless Charging Laboratory

    DOT National Transportation Integrated Search

    2018-03-23

    Wireless charging tests of electric vehicles (EV) have been conducted at the EVTC Wireless Laboratory located at the Florida Solar Energy Center, Cocoa, FL. These tests were performed to document testing protocols, evaluate standards and evaluate ope...

  10. MARLAP

    EPA Science Inventory

    MARLAP is being developed as a multi-agency guidance manual for project managers and radioanalytical laboratories. The document uses a performance based approach and will provide guidance and a framework to assure that laboratory radioanalytical data meets the specific project or...

  11. PHABSIM for Windows User's Manual and Exercises

    USGS Publications Warehouse

    Waddle, Terry

    2001-01-01

    This document is a combined self-study textbook and reference manual. The material is presented in the general order of a PHABSIM study placed within the context of an IFIM application. The document may also be used as reading material for a lecture-based course. This manual provides documentation of the various PHABSIM programs so every option of each program is treated.This text is not a guidebook for organization and implementation of a PHABSIM study. Use of PHABSIM should take place in the context of an IFIM application. See Bovee et al. (1998) for guidance in designing and performing a PHABSIM study as part of a larger IFIM application.The document concludes with a set of 12 laboratory exercises. Users are strongly encouraged to work through the laboratory exercises prior to applying the software to a study. Working through the exercises will enhance familiarity with the programs and answer many questions that may arise during a PHABSIM analysis.

  12. Hanford High-Level Waste Vitrification Program at the Pacific Northwest National Laboratory: technology development - annotated bibliography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larson, D.E.

    1996-09-01

    This report provides a collection of annotated bibliographies for documents prepared under the Hanford High-Level Waste Vitrification (Plant) Program. The bibliographies are for documents from Fiscal Year 1983 through Fiscal Year 1995, and include work conducted at or under the direction of the Pacific Northwest National Laboratory. The bibliographies included focus on the technology developed over the specified time period for vitrifying Hanford pretreated high-level waste. The following subject areas are included: General Documentation; Program Documentation; High-Level Waste Characterization; Glass Formulation and Characterization; Feed Preparation; Radioactive Feed Preparation and Glass Properties Testing; Full-Scale Feed Preparation Testing; Equipment Materials Testing; Meltermore » Performance Assessment and Evaluations; Liquid-Fed Ceramic Melter; Cold Crucible Melter; Stirred Melter; High-Temperature Melter; Melter Off-Gas Treatment; Vitrification Waste Treatment; Process, Product Control and Modeling; Analytical; and Canister Closure, Decontamination, and Handling« less

  13. Video Reports as a Novel Alternate Assessment in the Undergraduate Chemistry Laboratory

    ERIC Educational Resources Information Center

    Erdmann, Mitzy A.; March, Joe L.

    2014-01-01

    The increased use of video capable cellular phones to document everyday life presents educators with an exciting opportunity to extend this capability into the introductory laboratory. The study assessed whether students enrolled in a southeastern U.S. university's first-year laboratory course retained technical information at a higher rate after…

  14. Retrofit of waste-to-energy facilities equipped with electrostatic precipitators. Volume II: Field and Laboratory Reports, Part 1 of 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rigo, H.G.; Chandler, A.J.

    1996-04-01

    Volume II (part 1 of 2) of ''Retrofit of Waste-to-energy Facilities Equipped with Electrostatic Precipitators'' contains the documentation and raw data, including: (1) field reports, (2) analytic laboratory reports, (3) chain of custody forms, and (4) TCLP laboratory reports.

  15. The Shrub Sciences Laboratory at 25 Years: Retrospective and prospective

    Treesearch

    E. Durant McArthur

    2001-01-01

    The Shrub Sciences Laboratory celebrated its 25th anniversary with the symposium documented by these proceedings and a ceremony honoring people instrumental in its establishment: Mr. A. Perry Plummer represented Forest Service Research and Development and Dr. Howard C. Stutz represented Brigham Young University. The laboratory came into being because of the research...

  16. Microdamage healing in asphalt and asphalt concrete, Volume 2 : laboratory and field testing to assess and evaluate microdamage and microdamage healing

    DOT National Transportation Integrated Search

    2001-06-01

    Volume 2 documents laboratory and field testing that provides the evidence that microdamage healing is real and measurable and that it has a significant impact on pavement performance. Part of the laboratory experiments to evaluate the impact of rest...

  17. Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine.

    PubMed

    Wu, Alan H B; Christenson, Robert H; Greene, Dina N; Jaffe, Allan S; Kavsak, Peter A; Ordonez-Llanos, Jordi; Apple, Fred S

    2018-04-01

    This document is an essential companion to the third iteration of the National Academy of Clinical Biochemistry [NACB, 8 now the American Association for Clinical Chemistry (AACC) Academy] Laboratory Medicine Practice Guidelines (LMPG) on cardiac markers. The expert consensus recommendations were drafted in collaboration with the International Federation of Clinical Chemistry and Laboratory Medicine Task Force on Clinical Applications of Bio-Markers (IFCC TF-CB). We determined that there is sufficient clinical guidance on the use of cardiac troponin (cTn) testing from clinical practice groups. Thus, in this expert consensus document, we focused on clinical laboratory practice recommendations for high-sensitivity (hs)-cTn assays. This document utilized the expert opinion class of evidence to focus on the following 10 topics: ( a ) quality control (QC) utilization, ( b ) validation of the lower reportable analytical limits, ( c ) units to be used in reporting measurable concentrations for patients and QC materials, ( d ) 99th percentile sex-specific upper reference limits to define the reference interval; ( e ) criteria required to define hs-cTn assays, ( f ) communication with clinicians and the laboratory's role in educating clinicians regarding the influence of preanalytic and analytic problems that can confound assay results, ( g ) studies on hs-cTn assays and how authors need to document preanalytical and analytical variables, ( h ) harmonizing and standardizing assay results and the role of commutable materials, ( i ) time to reporting of results from sample receipt and sample collection, and ( j ) changes in hs-cTn concentrations over time and the role of both analytical and biological variabilities in interpreting results of serial blood collections. © 2017 American Association for Clinical Chemistry.

  18. Laboratory quality management system: road to accreditation and beyond.

    PubMed

    Wadhwa, V; Rai, S; Thukral, T; Chopra, M

    2012-01-01

    This review attempts to clarify the concepts of Laboratory Quality Management System (Lab QMS) for a medical testing and diagnostic laboratory in a holistic way and hopes to expand the horizon beyond quality control (QC) and quality assurance. It provides an insight on accreditation bodies and highlights a glimpse of existing laboratory practices but essentially it takes the reader through the journey of accreditation and during the course of reading and understanding this document, prepares the laboratory for the same. Some of the areas which have not been highlighted previously include: requirement for accreditation consultants, laboratory infrastructure and scope, applying for accreditation, document preparation. This section is well supported with practical illustrations and necessary tables and exhaustive details like preparation of a standard operating procedure and a quality manual. Concept of training and privileging of staff has been clarified and a few of the QC exercises have been dealt with in a novel way. Finally, a practical advice for facing an actual third party assessment and caution needed to prevent post-assessment pitfalls has been dealt with.

  19. US Army Research Laboratory Visualization Framework Architecture Document

    DTIC Science & Technology

    2018-01-11

    this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. Citation of...release; distribution is unlimited. 14. ABSTRACT Visualization of network science experimentation results is generally achieved using stovepipe...report documents the ARL Visualization Framework system design and specific details of its implementation. 15. SUBJECT TERMS visualization

  20. CLSI performance standards for antimicrobial susceptibility testing of bacteria isoloated from aquatic animals; second information supplement. CLSI document VET03/VET04-S2

    USDA-ARS?s Scientific Manuscript database

    The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI) approved documents VET03-A Methods for Antimicrobial Disk Susceptibility Testing of Bacte...

  1. Conceptual Design and Neutronics Analyses of a Fusion Reactor Blanket Simulation Facility

    DTIC Science & Technology

    1986-01-01

    Laboratory (LLL) ORNL Oak Ridge National Laboratory PPPL Princeton Plasma Physics Laboratory RSIC Reactor Shielding Information Center (at ORNL) SS...Module (LBM) to be placed in the TFTR at PPPL . Jassby et al. describe the program, including design, manufacturing techniques. neutronics analyses, and

  2. Cost challenges for laboratory medicine automation in Africa.

    PubMed

    Tanyanyiwa, Donald Moshen

    2010-01-01

    Automation in laboratory medicine is inevitable and the only way forward especially in Africa where the staff turnover is high due to migration of experienced staff to Europe and America. Described here are the common issues that laboratory Managers and Directors encounter when upgrading, replacing analytical systems as well as daily running of diagnostic laboratories. The rapid advancement driven by the first world where research facilities, resources and expertise are available has seen changes in the both the hardware and software utilised by analyzers every two to three years. The downside is that in the process of replacing/phasing out old analysers, the first world countries in some cases donate them to second and third world countries as refurbished analysers. Problems in obtaining spares ensue since the production of new analysers results in reduced production or even of old spares. Unavailability or delayed availability of spares results in suspension of diagnostic service by the recipient laboratory. In some areas costly modifications to the analysers or the location/building have had to done to suite local (African) conditions, hence the need for Laboratory managers to understand fully the analysers' operational requirements before purchasing or accepting donations.

  3. Methodology issues concerning the accuracy of kinematic data collection and analysis using the ariel performance analysis system

    NASA Technical Reports Server (NTRS)

    Wilmington, R. P.; Klute, Glenn K. (Editor); Carroll, Amy E. (Editor); Stuart, Mark A. (Editor); Poliner, Jeff (Editor); Rajulu, Sudhakar (Editor); Stanush, Julie (Editor)

    1992-01-01

    Kinematics, the study of motion exclusive of the influences of mass and force, is one of the primary methods used for the analysis of human biomechanical systems as well as other types of mechanical systems. The Anthropometry and Biomechanics Laboratory (ABL) in the Crew Interface Analysis section of the Man-Systems Division performs both human body kinematics as well as mechanical system kinematics using the Ariel Performance Analysis System (APAS). The APAS supports both analysis of analog signals (e.g. force plate data collection) as well as digitization and analysis of video data. The current evaluations address several methodology issues concerning the accuracy of the kinematic data collection and analysis used in the ABL. This document describes a series of evaluations performed to gain quantitative data pertaining to position and constant angular velocity movements under several operating conditions. Two-dimensional as well as three-dimensional data collection and analyses were completed in a controlled laboratory environment using typical hardware setups. In addition, an evaluation was performed to evaluate the accuracy impact due to a single axis camera offset. Segment length and positional data exhibited errors within 3 percent when using three-dimensional analysis and yielded errors within 8 percent through two-dimensional analysis (Direct Linear Software). Peak angular velocities displayed errors within 6 percent through three-dimensional analyses and exhibited errors of 12 percent when using two-dimensional analysis (Direct Linear Software). The specific results from this series of evaluations and their impacts on the methodology issues of kinematic data collection and analyses are presented in detail. The accuracy levels observed in these evaluations are also presented.

  4. [Modal failure analysis and effects in the detection of errors in the transport of samples to the clinical laboratory].

    PubMed

    Parés-Pollán, L; Gonzalez-Quintana, A; Docampo-Cordeiro, J; Vargas-Gallego, C; García-Álvarez, G; Ramos-Rodríguez, V; Diaz Rubio-García, M P

    2014-01-01

    Owing to the decrease in values of biochemical glucose parameter in some samples from external extraction centres, and the risk this implies to patient safety; it was decided to apply an adaptation of the «Health Services Failure Mode and Effects Analysis» (HFMEA) to manage risk during the pre-analytical phase of sample transportation from external centres to clinical laboratories. A retrospective study of glucose parameter was conducted during two consecutive months. The analysis was performed in its different phases: to define the HFMEA topic, assemble the team, graphically describe the process, conduct a hazard analysis, design the intervention and indicators, and identify a person to be responsible for ensuring completion of each action. The results of glucose parameter in one of the transport routes, were significantly lower (P=.006). The errors and potential causes of this problem were analysed, and criteria of criticality and detectability were applied (score≥8) in the decision tree. It was decided to: develop a document management system; reorganise extractions and transport routes in some centres; quality control of the sample container ice-packs, and the time and temperature during transportation. This work proposes quality indicators for controlling time and temperature of transported samples in the pre-analytical phase. Periodic review of certain laboratory parameters can help to detect problems in transporting samples. The HFMEA technique is useful for the clinical laboratory. Copyright © 2013 SECA. Published by Elsevier Espana. All rights reserved.

  5. IN SITU FIELD TESTING OF PROCESSES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J.S.Y. YANG

    2004-11-08

    The purpose of this scientific analysis report is to update and document the data and subsequent analyses from ambient field-testing activities performed in underground drifts and surface-based boreholes through unsaturated zone (UZ) tuff rock units. In situ testing, monitoring, and associated laboratory studies are conducted to directly assess and evaluate the waste emplacement environment and the natural barriers to radionuclide transport at Yucca Mountain. This scientific analysis report supports and provides data to UZ flow and transport model reports, which in turn contribute to the Total System Performance Assessment (TSPA) of Yucca Mountain, an important document for the license applicationmore » (LA). The objectives of ambient field-testing activities are described in Section 1.1. This report is the third revision (REV 03), which supercedes REV 02. The scientific analysis of data for inputs to model calibration and validation as documented in REV 02 were developed in accordance with the Technical Work Plan (TWP) ''Technical Work Plan for: Performance Assessment Unsaturated Zone'' (BSC 2004 [DIRS 167969]). This revision was developed in accordance with the ''Technical Work Plan for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654], Section 1.2.4) for better integrated, consistent, transparent, traceable, and more complete documentation in this scientific analysis report and associated UZ flow and transport model reports. No additional testing or analyses were performed as part of this revision. The list of relevant acceptance criteria is provided by ''Technical Work Plan for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654]), Table 3-1. Additional deviations from the TWP regarding the features, events, and processes (FEPs) list are discussed in Section 1.3. Documentation in this report includes descriptions of how, and under what conditions, the tests were conducted. The descriptions and analyses provide data useful for refining and confirming the understanding of flow, drift seepage, and transport processes in the UZ. The UZ testing activities included measurement of permeability distribution, quantification of the seepage of water into the drifts, evaluation of fracture-matrix interaction, study of flow along faults, testing of flow and transport between drifts, characterization of hydrologic heterogeneity along drifts, estimation of drying effects on the rock surrounding the drifts due to ventilation, monitoring of moisture conditions in open and sealed drifts, and determination of the degree of minimum construction water migration below drift. These field tests were conducted in two underground drifts at Yucca Mountain, the Exploratory Studies Facility (ESF) drift, and the cross-drift for Enhanced Characterization of the Repository Block (ECRB), as described in Section 1.2. Samples collected in boreholes and underground drifts have been used for additional hydrochemical and isotopic analyses for additional understanding of the UZ setting. The UZ transport tests conducted at the nearby Busted Butte site (see Figure 1-4) are also described in this scientific analysis report.« less

  6. Quality-Assurance/Quality-Control Manual for Collection and Analysis of Water-Quality Data in the Ohio District, US Geological Survey

    USGS Publications Warehouse

    Francy, D.S.; Jones, A.L.; Myers, Donna N.; Rowe, G.L.; Eberle, Michael; Sarver, K.M.

    1998-01-01

    The U.S. Geological Survey (USGS), Water Resources Division (WRD), requires that quality-assurance/quality-control (QA/QC) activities be included in any sampling and analysis program. Operational QA/QC procedures address local needs while incorporating national policies. Therefore, specific technical policies were established for all activities associated with water-quality project being done by the Ohio District. The policies described in this report provide Ohio District personnel, cooperating agencies, and others with a reference manual on QA/QC procedures that are followed in collecitng and analyzing water-quality samples and reporting water-quality information in the Ohio District. The project chief, project support staff, District Water-Quality Specialist, and District Laboratory Coordinator are all involved in planning and implementing QA/QC activities at the district level. The District Chief and other district-level managers provide oversight, and the Regional Water-Quality Specialist, Office of Water Quality (USGS headquarters), and the Branch of Quality Systems within the Office of Water Quality create national QA/QC polices and provide assistance to District personnel. In the literature, the quality of all measurement data is expressed in terms of precision, variability, bias, accuracy, completeness, representativeness, and comparability. In the Ohio District, bias and variability will be used to describe quality-control data generated from samples in the field and laboratory. Each project chief must plan for implementation and financing of QA/QC activities necessary to achieve data-quality objectives. At least 15 percent of the total project effort must be directed toward QA/QC activities. Of this total, 5-10 percent will be used for collection and analysis of quality-control samples. This is an absolute minimum, and more may be required based on project objectives. Proper techniques must be followed in the collection and processing of surface-water, ground-water, biological, precipitation, bed-sediment, bedload, suspended-sediment, and solid-phase samples. These techniques are briefly described in this report and are extensively documented. The reference documents listed in this report will be kept by the District librarian and District Water-Quality Specialist and updated regularly so that they are available to all District staff. Proper handling and documentation before, during, and after field activities are essential to ensure the integrity of the sample and to correct erroneous reporting of data results. Field sites are to be properly identified and entered into the data base before field data-collection activities begin. During field activities, field notes are to be completed and sample bottles appropriately labeled a nd stored. After field activities, all paperwork is to be completed promptly and samples transferred to the laboratory within allowable holding times. All equipment used by District personnel for the collection and processing of water-quality samples is to be properly operated, maintained, and calibrated by project personnel. This includes equipment for onsite measurement of water-quality characteristics (temperature, specific conductance, pH, dissolved oxygen, alkalinity, acidity, and turbidity) and equipment and instruments used for biological sampling. The District Water-Quality Specialist and District Laboratory Coordinator are responsible for preventive maintenance and calibration of equipment in the Ohio District laboratory. The USGS National Water Quality Laboratory in Arvada, Colo., is the primary source of analytical services for most project work done by the Ohio District. Analyses done at the Ohio District laboratory are usually those that must be completed within a few hours of sample collection. Contract laboratories or other USGS laboratories are sometimes used instead of the NWQL or the Ohio District laboratory. When a contract laboratory is used, the projec

  7. 77 FR 8298 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... a quantitative, comprehensive or even representative survey or study of the burdens associated with... existing registered money market fund: Documentation of credit risk analyses, and determinations regarding... for documentation of credit analyses and other determinations) = 2340 responses. (30 funds x 12...

  8. Paleomagnetic and Magnetostratigraphic Studies in Drilling Projects of Impact Craters - Recent Studies, Challenges and Perspectives

    NASA Astrophysics Data System (ADS)

    Fucugauchi, J. U.; Velasco-Villarreal, M.; Perez-Cruz, L. L.

    2013-05-01

    Paleomagnetic studies have long been successfully carried out in drilling projects, to characterize the borehole columns and to investigate the subsurface structure and stratigraphy. Magnetic susceptibility logging and magnetostratigraphic studies provide data for lateral correlation, formation evaluation, azimuthal core orientation, physical properties, etc., and are part of the tools available in the ocean and continental drilling programs. The inclusion of continuous core recovery in scientific drilling projects have greatly expanded the range of potential applications of paleomagnetic and rock magnetic studies, by allowing laboratory measurements on core samples. For this presentation, we concentrate on drilling studies of impact structures and their usefulness for documenting the structure, stratigraphy and physical properties at depth. There are about 170-180 impact craters documented in the terrestrial record, which is a small number compared to what is observed in the Moon, Mars, Venus and other bodies of the solar system. Of the terrestrial impact craters, only a few have been studied by drilling. Some craters have been drilled as part of industry exploration surveys and/or academic projects, including notably the Sudbury, Ries, Vredefort, Manson and many other craters. As part of the Continental ICDP program, drilling projects have been conducted on the Chicxulub, Bosumtwi, Chesapeake and El gygytgyn craters. Drilling of terrestrial craters has proved important in documenting the shallow stratigraphy and structure, providing insight on the cratering and impact dynamics. Questions include several that can only be addressed by retrieving core samples and laboratory analyses. Paleomagnetic, rock magnetic and fabric studies have been conducted in the various craters, which are here summarized with emphasis on the Chicxulub crater and Yucatan carbonate platform. Chicxulub is buried under a kilometer of younger sediments, making drilling an essential tool. Oil exploration included several boreholes, and additionally we have drilled 11 boreholes with continuous core recovery. Contributions and limitations of paleomagnetism for investigating the impact age, crater stratigraphy, cratering, ejecta emplacement, impact dynamics, hydrothermal system and post-impact processes are discussed.

  9. 9 CFR 590.580 - Laboratory tests and analyses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Laboratory tests and analyses. 590.580 Section 590.580 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sequence, frequency, and approved laboratory methods as prescribed by the AMS Science Division Director...

  10. 9 CFR 590.580 - Laboratory tests and analyses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Laboratory tests and analyses. 590.580 Section 590.580 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sequence, frequency, and approved laboratory methods as prescribed by the AMS Science Division Director...

  11. 9 CFR 590.580 - Laboratory tests and analyses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Laboratory tests and analyses. 590.580 Section 590.580 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sequence, frequency, and approved laboratory methods as prescribed by the AMS Science Division Director...

  12. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE (NELAC): CONSTITUTION, BYLAWS, AND STANDARDS

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  13. Los Alamos and Lawrence Livermore National Laboratories Code-to-Code Comparison of Inter Lab Test Problem 1 for Asteroid Impact Hazard Mitigation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weaver, Robert P.; Miller, Paul; Howley, Kirsten

    The NNSA Laboratories have entered into an interagency collaboration with the National Aeronautics and Space Administration (NASA) to explore strategies for prevention of Earth impacts by asteroids. Assessment of such strategies relies upon use of sophisticated multi-physics simulation codes. This document describes the task of verifying and cross-validating, between Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL), modeling capabilities and methods to be employed as part of the NNSA-NASA collaboration. The approach has been to develop a set of test problems and then to compare and contrast results obtained by use of a suite of codes, includingmore » MCNP, RAGE, Mercury, Ares, and Spheral. This document provides a short description of the codes, an overview of the idealized test problems, and discussion of the results for deflection by kinetic impactors and stand-off nuclear explosions.« less

  14. Department of Defense Enterprise Requirements and Acquisition Model

    DTIC Science & Technology

    2011-06-01

    Laboratories’ Center for Reengineering and Enabling Technology ( CRET ) to develop the APM. The APM is a compilation of policy, instructions, and...CDD Capabilities Development Document CBA Capabilities-Based Assessment CPD Capability Production Document CRET Center for Re-engineering

  15. Visualization of CDA laboratory reports and long term trends as a possible EHR application for patients and physicians.

    PubMed

    Obenaus, Manuel; Burgsteiner, Harald

    2014-01-01

    To increase the patient's acceptance of electronic health records and understanding for their laboratory findings a web application was developed which presents all parameters and possible deviations of standard values in a clear way and visualizes the time based trend of all recorded parameters graphically. Documents corresponding to the Clinical document architecture (CDA) R2 laboratory reports standard and a rapid prototyping framework called Groovy on Grails were used. This work shows, that it is possible to create a useful, standards based tool for patients and physicians with comparatively few resources - an application that could be in similar form a part of an electronic Health Record (EHR) system like the Austrian electronic Health Record (ELGA).

  16. Technical requirements for bioassay support services

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hickman, D.P.; Anderson, A.L.

    1991-05-01

    This document provides the technical basis for the Chem-Nuclear Geotech (Geotech) bioassay program. It includes information and details that can be used as a model in providing technical contents and requirements for bioassay laboratory support, either internally or in solicitations by Geotech to obtain subcontractor laboratory support. It provides a detailed summary and description of the types of bioassay samples to be expected in support of Geotech remedial projects for the US Department of Energy and the bioassay services and analytical requirements necessary to process such samples, including required limits of sensitivity. General responsibilities of the bioassay laboratory are alsomore » addressed, including quality assurance. Peripheral information of importance to the program is included in the appendices of this document. 7 tabs.« less

  17. FINAL REPORT FOR THE REDUCTION OF CHROME (VI) TO CHROME (III) IN THE SECONDARY WASTE STREAM OF THE EFFLUENT TREATMENT FACILITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DUNCAN JB; GUTHRIE MD

    2008-08-29

    This report documents the laboratory results of RPP-PLAN-35958, Test Plan for the Effluent Treatment Facility to Reduce Chrome (VI) to Chrome (III) in the Secondary Waste Stream With the exception of the electrochemical corrosion scans, all work was carried out at the Center for Laboratory Science (CLS) located at the Columbia Basin College. This document summarizes the work carried out at CLS and includes the electrochemical scans and associated corrosion rates for 304 and 316L stainless steel.

  18. Data Quality Objectives Supporting the Environmental Soil Monitoring Program for the Idaho National Laboratory Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haney, Thomas Jay

    This document describes the process used to develop data quality objectives for the Idaho National Laboratory (INL) Environmental Soil Monitoring Program in accordance with U.S. Environmental Protection Agency guidance. This document also develops and presents the logic that was used to determine the specific number of soil monitoring locations at the INL Site, at locations bordering the INL Site, and at locations in the surrounding regional area. The monitoring location logic follows the guidance from the U.S. Department of Energy for environmental surveillance of its facilities.

  19. Diagnosis of coccidioidomycosis by culture: safety considerations, traditional methods, and susceptibility testing.

    PubMed

    Sutton, Deanna A

    2007-09-01

    The recovery of Coccidioides spp. by culture and confirmation utilizing the AccuProbe nucleic acid hybridization method by GenProbe remain the definitive diagnostic method. Biosafety considerations from specimen collection through culture confirmation in the mycology laboratory are critical, as acquisition of coccidioidomycosis by laboratory workers is well documented. The designation of Coccidioides spp. as select agents of potential bioterrorism has mandated strict regulation of their transport and inventory. The genus appears generally susceptible, in vitro, although no defined breakpoints exist. Susceptibility testing may assist in documenting treatment failures.

  20. 77 FR 23515 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... from a quantitative, comprehensive or even representative survey or study of the burdens associated... existing registered money market fund: Documentation of credit risk analyses, and determinations regarding... for documentation of credit analyses and other determinations) = 2340 responses. (30 funds x 12...

  1. Supplement analysis for continued operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore. Volume 2: Comment response document

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1999-03-01

    The US Department of Energy (DOE), prepared a draft Supplement Analysis (SA) for Continued Operation of Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories, Livermore (SNL-L), in accordance with DOE`s requirements for implementation of the National Environmental Policy Act of 1969 (NEPA) (10 Code of Federal Regulations [CFR] Part 1021.314). It considers whether the Final Environmental Impact Statement and Environmental Impact Report for Continued Operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore (1992 EIS/EIR) should be supplement3ed, whether a new environmental impact statement (EIS) should be prepared, or no further NEPA documentation is required. The SAmore » examines the current project and program plans and proposals for LLNL and SNL-L, operations to identify new or modified projects or operations or new information for the period from 1998 to 2002 that was not considered in the 1992 EIS/EIR. When such changes, modifications, and information are identified, they are examined to determine whether they could be considered substantial or significant in reference to the 1992 proposed action and the 1993 Record of Decision (ROD). DOE released the draft SA to the public to obtain stakeholder comments and to consider those comments in the preparation of the final SA. DOE distributed copies of the draft SA to those who were known to have an interest in LLNL or SNL-L activities in addition to those who requested a copy. In response to comments received, DOE prepared this Comment Response Document.« less

  2. Software Engineering Laboratory Series: Proceedings of the Twentieth Annual Software Engineering Workshop

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  3. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 15

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  4. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 14

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  5. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 13

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  6. Finding Edges and Lines in Images.

    DTIC Science & Technology

    1983-06-01

    34 UNCLASSI FlED , SECURITY CLASSIFICATION OF THIS PAGE ("osen Data Entered) READ INSTRUCTIONSREPORT DOCUMENTATION PAGE BEFORE COMPLETING FORM I. REPORT...PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK Artificial Intelligence Laboratory AREA&WORKUNITNUMBERS 545 Technology Square...in the Artificial Intelligence Laboratory of the Massachusetts Institute of Technology. Support for the laboratory’s artificial intelligence research

  7. General Science, Ninth Grade: Theme III and Theme IV. Student Laboratory Manual. Experimental.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This document is the student laboratory manual that was designed to accompany some of the experimental activities found in the teacher's guide to this general science course for ninth graders. It contains laboratory worksheets for lessons on such topics as: (1) soil; (2) hazardous waste; (3) wildlife refuges; (4) the water cycle; (5) water…

  8. Writing Material in Chemical Physics Research: The Laboratory Notebook as Locus of Technical and Textual Integration

    ERIC Educational Resources Information Center

    Wickman, Chad

    2010-01-01

    This article, drawing on ethnographic study in a chemical physics research facility, explores how notebooks are used and produced in the conduct of laboratory science. Data include written field notes of laboratory activity; visual documentation of "in situ" writing processes; analysis of inscriptions, texts, and material artifacts produced in the…

  9. Mississippi Curriculum Framework for Medical Laboratory Technology Programs (CIP: 51.1004--Medical Laboratory Technology). Postsecondary Programs.

    ERIC Educational Resources Information Center

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the medical laboratory technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

  10. Indicators of recent geodynamic activity in the Książ Castle area (Świebodzice Unit, Sudetes) in the light of structural analysis and geodetic measurements

    NASA Astrophysics Data System (ADS)

    Kasza, Damian; Kowalski, Aleksander; Wojewoda, Jurand; Kaczorowski, Marek

    2018-01-01

    Abstract. Indicators of recent geodynamic activity in the Książ Castle area are registered by the measuring instruments of the SRC PAS (Space Research Centre of Polish Academy of Sciences) Geodynamic Laboratory at Książ. Over 40 years of continuous observations from quartz horizontal pendulums (since 1974) and over 10 years of observations from water-tube tiltmeters (since 2002) have documented irregularly repeatable strong signals related to the relative displacement of blocks in the rock substrate, on which Książ Castle is located. These signals have dip (rotational) and vertical strike-slip components. Also, the presence of a horizontal strike-slip component is evidenced by geometric anomalies (deformations) of the shape of the Pelcznica river valley, which directly correspond to the orientation of the main faults in the area. Recent geodynamic activity is documented by destruction of (the construction elements in the castle complex. Instrumental indicators of movement, geodetic measurements and structural analysis of the rock massif have allowed for constructing a model showing the main unconformity surfaces in the analysed rock massif. Sinistral, NE-SW and ENE-WSW-oriented strike-slip faults prevail in the laboratory corridors, along with perpendicular WNW-ESE and NW-SSE-oriented clextral and normal faults. Most dislocations are accompanied by zones of intense cataclasys, secondary silification, and Fe and Mn mineralization. Generally, the faults were formed due to reactivation of joint fractures cutting the steeply N-and S-dipping (at 75-90°) deposits of the Książ Conglomerate Formation.

  11. OHD/HL - Staff

    Science.gov Websites

    Laboratory Branches Hydrologic Software Engineering Branch (HSEB) Hydrologic Science and Modeling Branch (HSMB) General Info Publications Documentation Software Standard and Guidelines Contact Us HL Staff resources and services. Staff Directory Chief, Hydrology Laboratory; Chief, Hydrologic Software Engineering

  12. Trackless tack coat materials : a laboratory evaluation performance acceptance.

    DOT National Transportation Integrated Search

    2012-06-01

    The purpose of this study was to develop, demonstrate, and document laboratory procedures that could be used by the : Virginia Department of Transportation (VDOT) to evaluate non-tracking tack coat materials. The procedures would be used to : qualify...

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    David, S.A.; Goodwin, G.M.; Gardner, K.

    This document contains a listing of the written scientific information originating in the Materials Joining (formerly the Welding and Brazing Group), Metals and Ceramics Division, Oak Ridge National Laboratory during 1951 through June 1991. This registry of documents is as much as possible, in the order of issue date.

  14. Directory of Energy Information Administration model abstracts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1987-08-11

    This report contains brief statements from the model managers about each model's title, acronym, purpose, and status, followed by more detailed information on characteristics, uses, and requirements. Sources for additional information are identified. All models ''active'' through March 1987 are included. The main body of this directory is an alphabetical list of all active EIA models. Appendix A identifies major EIA modeling systems and the models within these systems, and Appendix B identifies active EIA models by type (basic, auxiliary, and developing). A basic model is one designated by the EIA Administrator as being sufficiently important to require sustained supportmore » and public scrutiny. An auxiliary model is one designated by the EIA Administrator as being used only occasionally in analyses, and therefore requires minimal levels of documentation. A developing model is one designated by the EIA Administrator as being under development and yet of sufficient interest to require a basic level of documentation at a future date. EIA also leases models developed by proprietary software vendors. Documentation for these ''proprietary'' models is the responsibility of the companies from which they are leased. EIA has recently leased models from Chase Econometrics, Inc., Data Resources, Inc. (DRI), the Oak Ridge National Laboratory (ORNL), and Wharton Econometric Forecasting Associates (WEFA). Leased models are not abstracted here. The directory is intended for the use of energy and energy-policy analysts in the public and private sectors.« less

  15. ADM guidance-Ceramics: guidance to the use of fractography in failure analysis of brittle materials.

    PubMed

    Scherrer, Susanne S; Lohbauer, Ulrich; Della Bona, Alvaro; Vichi, Alessandro; Tholey, Michael J; Kelly, J Robert; van Noort, Richard; Cesar, Paulo Francisco

    2017-06-01

    To provide background information and guidance as to how to use fractography accurately, a powerful tool for failure analysis of dental ceramic structures. An extended palette of qualitative and quantitative fractography is provided, both for in vivo and in vitro fracture surface analyses. As visual support, this guidance document will provide micrographs of typical critical ceramic processing flaws, differentiating between pre- versus post sintering cracks, grinding damage related failures and occlusal contact wear origins and of failures due to surface degradation. The documentation emphasizes good labeling of crack features, precise indication of the direction of crack propagation (dcp), identification of the fracture origin, the use of fractographic photomontage of critical flaws or flaw labeling on strength data graphics. A compilation of recommendations for specific applications of fractography in Dentistry is also provided. This guidance document will contribute to a more accurate use of fractography and help researchers to better identify, describe and understand the causes of failure, for both clinical and laboratory-scale situations. If adequately performed at a large scale, fractography will assist in optimizing the methods of processing and designing of restorative materials and components. Clinical failures may be better understood and consequently reduced by sending out the correct message regarding the fracture origin in clinical trials. Copyright © 2017 The Academy of Dental Materials. All rights reserved.

  16. Heterotrophic Archaea Contribute to Carbon Cycling in Low-pH, Suboxic Biofilm Communities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Justice, Nicholas B; Pan, Chongle; Mueller, Ryan

    Archaea are widely distributed and yet are most often not the most abundant members of microbial communities. Here, we document a transition from Bacteria- to Archaea-dominated communities in microbial biofilms sampled from the Richmond Mine acid mine drainage (AMD) system (pH 1.0,38 C) and in laboratory-cultivated biofilms. This transition occurs when chemoautotrophic microbial communities that develop at the air-solution interface sink to the sediment-solution interface and degrade under microaerobic and anaerobic conditions. The archaea identified in these sunken biofilms are from the class Thermoplasmata, and in some cases, the highly divergent ARMAN nanoarchaeal lineage. In several of the sunken biofilms,more » nanoarchaea comprise 10 to 25% of the community, based on fluorescent in situ hybridization and metagenomic analyses. Comparative community proteomic analyses show a persistence of bacterial proteins in sunken biofilms, but there is clear evidence for amino acid modifications due to acid hydrolysis. Given the low representation of bacterial cells in sunken biofilms based on microscopy, we infer that hydrolysis reflects proteins derived from lysed cells. For archaea, we detected 2,400 distinct proteins, including a subset involved in proteolysis and peptide uptake. Laboratory cultivation experiments using complex carbon substrates demonstrated anaerobic enrichment of Ferroplasma and Aplasma coupled to the reduction of ferric iron. These findings indicate dominance of acidophilic archaea in degrading biofilms and suggest that they play roles in anaerobic nutrient cycling at low pH.« less

  17. The effect of participation in an extended inquiry project on general chemistry student laboratory interactions, confidence, and process skills

    NASA Astrophysics Data System (ADS)

    Krystyniak, Rebecca A.

    2001-12-01

    This study explored the effect of participation by second-semester general chemistry students in an extended open-inquiry laboratory investigation on their use of science process skills and confidence in performing specific aspects of laboratory investigations. In addition, verbal interactions of a student lab team among team members and with their instructor over three open-inquiry laboratory sessions and two non-inquiry sessions were investigated. Instruments included the Test of Integrated Skills (TIPS), a 36-item multiple-choice instrument, and the Chemistry Laboratory Survey (CLS), a researcher co-designed 20-item 8-point instrument. Instruments were administered at the beginning and close of the semester to 157 second-semester general chemistry students at the two universities; students at only one university participated in open-inquiry activity. A MANCOVA was performed to investigate relationships among control and experimental students, TIPS, and CLS post-test scores. Covariates were TIPS and CLS pre-test scores and prior high school and college science experience. No significant relationships were found. Wilcoxen analyses indicated both groups showed increase in confidence; experimental-group students with below-average TIPS pre-test scores showed a significant increase in science process skills. Transcribed audio tapes of all laboratory-based verbal interactions were analyzed. Coding categories, developed using the constant comparison method, led to an inter-rater reliability of .96. During open-inquiry activities, the lab team interacted less often, sought less guidance from their instructor, and talked less about chemistry concepts than during non-inquiry activities. Evidence confirmed that students used science process skills and engaged in higher-order thinking during both types of activities. A four-student focus shared their experiences with open-inquiry activities, indicating that they enjoyed the experience, viewed it as worthwhile, and believed it helped them gain understanding of the nature of chemistry research. Research results indicate that participation in open-inquiry laboratory increases student confidence and, for some students, the ability to use science process skills. Evidence documents differences in student laboratory interactions and behavior that are attributable to the type of laboratory experience. Further research into aspects of open-inquiry laboratory experiences is recommended.

  18. Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.

    PubMed

    Culver, Bruce H; Graham, Brian L; Coates, Allan L; Wanger, Jack; Berry, Cristine E; Clarke, Patricia K; Hallstrand, Teal S; Hankinson, John L; Kaminsky, David A; MacIntyre, Neil R; McCormack, Meredith C; Rosenfeld, Margaret; Stanojevic, Sanja; Weiner, Daniel J

    2017-12-01

    The American Thoracic Society committee on Proficiency Standards for Pulmonary Function Laboratories has recognized the need for a standardized reporting format for pulmonary function tests. Although prior documents have offered guidance on the reporting of test data, there is considerable variability in how these results are presented to end users, leading to potential confusion and miscommunication. A project task force, consisting of the committee as a whole, was approved to develop a new Technical Standard on reporting pulmonary function test results. Three working groups addressed the presentation format, the reference data supporting interpretation of results, and a system for grading quality of test efforts. Each group reviewed relevant literature and wrote drafts that were merged into the final document. This document presents a reporting format in test-specific units for spirometry, lung volumes, and diffusing capacity that can be assembled into a report appropriate for a laboratory's practice. Recommended reference sources are updated with data for spirometry and diffusing capacity published since prior documents. A grading system is presented to encourage uniformity in the important function of test quality assessment. The committee believes that wide adoption of these formats and their underlying principles by equipment manufacturers and pulmonary function laboratories can improve the interpretation, communication, and understanding of test results.

  19. 7 CFR 93.12 - Analyses available and locations of laboratories.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

  20. 7 CFR 93.12 - Analyses available and locations of laboratories.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

  1. 7 CFR 93.12 - Analyses available and locations of laboratories.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

  2. 7 CFR 93.12 - Analyses available and locations of laboratories.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

  3. 7 CFR 93.12 - Analyses available and locations of laboratories.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AMS Science and Technology (S&T) Aflatoxin Laboratories: (1) USDA, AMS, S&T 1211 Schley Avenue, Albany... Science and Technology (S&T) Aflatoxin Laboratories at Madill, Oklahoma and Blakely, Georgia will perform... matter, and oil (fat) content. (2) All of the analyses described in paragraph (b)(1) of this section...

  4. Point-of-care testing of electrolytes and calcium using blood gas analysers: it is time we trusted the results.

    PubMed

    Mirzazadeh, Mehdi; Morovat, Alireza; James, Tim; Smith, Ian; Kirby, Justin; Shine, Brian

    2016-03-01

    Point-of-care testing allows rapid analysis of samples to facilitate prompt clinical decisions. Electrolyte and calcium abnormalities are common in acutely ill patients and can be associated with life-threatening consequences. There is uncertainty whether clinical decisions can be based on the results obtained from blood gas analysers or if laboratory results should be awaited. To assess the agreement between sodium, potassium and calcium results from blood gas and laboratory mainstream analysers in a tertiary centre, with a network consisting of one referral and two peripheral hospitals, consisting of three networked clinical biochemistry laboratories. Using the laboratory information management system database and over 11 000 paired samples in three hospital sites, the results of sodium, potassium and ionised calcium on blood gas analysers were studied over a 5-year period and compared with the corresponding laboratory results from the same patients booked in the laboratory within 1 h. The Pearson's linear correlation coefficient between laboratory and blood gas results for sodium, potassium and calcium were 0.92, 0.84 and 0.78, respectively. Deming regression analysis showed a slope of 1.04 and an intercept of -5.7 for sodium, slope of 0.93 and an intercept of 0.22 for potassium and a slope of 1.23 with an intercept of -0.55 for calcium. With some strict statistical assumptions, percentages of results lying outside the least significant difference were 9%, 26.7% and 20.8% for sodium, potassium and calcium, respectively. Most clinicians wait for the laboratory confirmation of results generated by blood gas analysers. In a large retrospective study we have shown that there is sufficient agreement between the results obtained from the blood gas and laboratory analysers to enable prompt clinical decisions to be made. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  5. Collected Software Engineering Papers, Volume 10

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This document is a collection of selected technical papers produced by participants in the Software Engineering Laboratory (SEL) from Oct. 1991 - Nov. 1992. The purpose of the document is to make available, in one reference, some results of SEL research that originally appeared in a number of different forums. Although these papers cover several topics related to software engineering, they do not encompass the entire scope of SEL activities and interests. Additional information about the SEL and its research efforts may be obtained from the sources listed in the bibliography at the end of this document. For the convenience of this presentation, the 11 papers contained here are grouped into 5 major sections: (1) the Software Engineering Laboratory; (2) software tools studies; (3) software models studies; (4) software measurement studies; and (5) Ada technology studies.

  6. VALIDATION GUIDELINES FOR LABORATORIES PERFORMING FORENSIC ANALYSIS OF CHEMICAL TERRORISM

    EPA Science Inventory

    The Scientific Working Group on Forensic Analysis of Chemical Terrorism (SWGFACT) has developed the following guidelines for laboratories engaged in the forensic analysis of chemical evidence associated with terrorism. This document provides a baseline framework and guidance for...

  7. 42 CFR 493.1495 - Standard; Testing personnel responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... samples are tested in the same manner as patient specimens; (3) Adhere to the laboratory's quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived...

  8. RECENT PUBLICATIONS - ISOTOPE HYDROLOGY LABORATORY (WATER QUALITY MANAGEMENT BRANCH, WSWRD, NRMRL)

    EPA Science Inventory

    NRMRL's Water Supply and Water Resouces Division's Isotope Hydrology Laboratory (IHL) produces and publishes highly specialized technical and scientific documents relating to IHL's research. The mission of IHL is to resolve environmental hydrology problems through research and ap...

  9. NATIONAL ENVIRONMENTAL LABORATORY ACCREDITATION CONFERENCE; CONSTITUTION, BYLAWS AND STANDARDS: APPROVED MAY 25, 2001

    EPA Science Inventory

    The principles and operating procedures for the National Environmental Laboratory Accreditation Conference (NELAC) are contained in the NELAC Constitution and Bylaws. The major portion of this document (standards) contains detailed requirements for accrediting environmental labo...

  10. Geoengineering properties of potential repository units at Yucca Mountain, southern Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tillerson, J.R.; Nimick, F.B.

    1984-12-01

    The Nevada Nuclear Waste Storage Investigations (NNWSI) Project is currently evaluating volcanic tuffs at the Yucca Mountain site, located on and adjacent to the Nevada Test Site, for possible use as a host rock for a radioactive waste repository. The behavior of tuff as an engineering material must be understood to design, license, construct, and operate a repository. Geoengineering evaluations and measurements are being made to develop confidence in both the analysis techniques for thermal, mechanical, and hydrothermal effects and the supporting data base of rock properties. The analysis techniques and the data base are currently used for repository design,more » waste package design, and performance assessment analyses. This report documents the data base of geoengineering properties used in the analyses that aided the selection of the waste emplacement horizon and in analyses synopsized in the Environmental Assessment Report prepared for the Yucca Mountain site. The strategy used for the development of the data base relies primarily on data obtained in laboratory tests that are then confirmed in field tests. Average thermal and mechanical properties (and their anticipated variations) are presented. Based upon these data, analyses completed to date, and previous excavation experience in tuff, it is anticipated that existing mining technology can be used to develop stable underground openings and that repository operations can be carried out safely.« less

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Watson, C.R.

    The SNODOG Glossary is used by the DOE-supported life-span beagle studies to describe medical observations in a standardized format. It is an adaptation of the human medical glossary, SNOMED, which lists 107,165 terms. Each of the five laboratories, Argonne National Laboratory, the Inhalation Toxicology Research Institute, the Pacific Northwest Laboratory, the University of California at Davis, and the University of Utah, has selected an appropriate subset from the published SNOMED glossary and added beagle and research-specific terms. The National Radiobiology Archives is the coordinator of these enhancements, and periodically distributes SNODOG to the respective laboratories. Information donated by Colorado Statemore » University and Oak Ridge National Laboratory has been related to SNODOG and is available in a standardized format. This document is designed for the database manager and the scientist who will be managing or coding medical observations. It is also designed for the scientist analyzing coded information. The document includes: an overview of the NRA and the SNODOG glossary, a discussion of hardware requirements, a review of the SNODOG code structure and printed lists of the 4,770 terms which have been used at least once. Instructions for obtaining electronic copies of the glossary and for nominating additional terms are provided. This document describes the origins and structure of the SNODOG codes, explains code usage at each participating institution, and presents a usage frequency tabulation of the terms for neoplasia. A diskette or magnetic tape containing 15,641 SNODOG codes and translations is available on request.« less

  12. SNODOG Glossary: Part 1, Introduction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Watson, C.R.

    The SNODOG Glossary is used by the DOE-supported life-span beagle studies to describe medical observations in a standardized format. It is an adaptation of the human medical glossary, SNOMED, which lists 107,165 terms. Each of the five laboratories, Argonne National Laboratory, the Inhalation Toxicology Research Institute, the Pacific Northwest Laboratory, the University of California at Davis, and the University of Utah, has selected an appropriate subset from the published SNOMED glossary and added beagle and research-specific terms. The National Radiobiology Archives is the coordinator of these enhancements, and periodically distributes SNODOG to the respective laboratories. Information donated by Colorado Statemore » University and Oak Ridge National Laboratory has been related to SNODOG and is available in a standardized format. This document is designed for the database manager and the scientist who will be managing or coding medical observations. It is also designed for the scientist analyzing coded information. The document includes: an overview of the NRA and the SNODOG glossary, a discussion of hardware requirements, a review of the SNODOG code structure and printed lists of the 4,770 terms which have been used at least once. Instructions for obtaining electronic copies of the glossary and for nominating additional terms are provided. This document describes the origins and structure of the SNODOG codes, explains code usage at each participating institution, and presents a usage frequency tabulation of the terms for neoplasia. A diskette or magnetic tape containing 15,641 SNODOG codes and translations is available on request.« less

  13. Blood gas testing and related measurements: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine.

    PubMed

    Dukić, Lora; Kopčinović, Lara Milevoj; Dorotić, Adrijana; Baršić, Ivana

    2016-10-15

    Blood gas analysis (BGA) is exposed to risks of errors caused by improper sampling, transport and storage conditions. The Clinical and Laboratory Standards Institute (CLSI) generated documents with recommendations for avoidance of potential errors caused by sample mishandling. Two main documents related to BGA issued by the CLSI are GP43-A4 (former H11-A4) Procedures for the collection of arterial blood specimens; approved standard - fourth edition, and C46-A2 Blood gas and pH analysis and related measurements; approved guideline - second edition. Practices related to processing of blood gas samples are not standardized in the Republic of Croatia. Each institution has its own protocol for ordering, collection and analysis of blood gases. Although many laboratories use state of the art analyzers, still many preanalytical procedures remain unchanged. The objective of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) is to standardize the procedures for BGA based on CLSI recommendations. The Working Group for Blood Gas Testing as part of the Committee for the Scientific Professional Development of the CSMBLM prepared a set of recommended protocols for sampling, transport, storage and processing of blood gas samples based on relevant CLSI documents, relevant literature search and on the results of Croatian survey study on practices and policies in acid-base testing. Recommendations are intended for laboratory professionals and all healthcare workers involved in blood gas processing.

  14. Blood gas testing and related measurements: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine

    PubMed Central

    Dukić, Lora; Kopčinović, Lara Milevoj; Dorotić, Adrijana; Baršić, Ivana

    2016-01-01

    Blood gas analysis (BGA) is exposed to risks of errors caused by improper sampling, transport and storage conditions. The Clinical and Laboratory Standards Institute (CLSI) generated documents with recommendations for avoidance of potential errors caused by sample mishandling. Two main documents related to BGA issued by the CLSI are GP43-A4 (former H11-A4) Procedures for the collection of arterial blood specimens; approved standard – fourth edition, and C46-A2 Blood gas and pH analysis and related measurements; approved guideline – second edition. Practices related to processing of blood gas samples are not standardized in the Republic of Croatia. Each institution has its own protocol for ordering, collection and analysis of blood gases. Although many laboratories use state of the art analyzers, still many preanalytical procedures remain unchanged. The objective of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) is to standardize the procedures for BGA based on CLSI recommendations. The Working Group for Blood Gas Testing as part of the Committee for the Scientific Professional Development of the CSMBLM prepared a set of recommended protocols for sampling, transport, storage and processing of blood gas samples based on relevant CLSI documents, relevant literature search and on the results of Croatian survey study on practices and policies in acid-base testing. Recommendations are intended for laboratory professionals and all healthcare workers involved in blood gas processing. PMID:27812301

  15. The importance of having a flexible scope ISO 15189 accreditation and quality specifications based on biological variation – the case of validation of the biochemistry analyzer Dimension Vista

    PubMed Central

    Fernandez-Calle, Pilar; Pelaz, Sandra; Oliver, Paloma; Alcaide, Maria Jose; Gomez-Rioja, Ruben; Buno, Antonio; Iturzaeta, Jose Manuel

    2013-01-01

    Introduction Technological innovation requires the laboratories to ensure that modifications or incorporations of new techniques do not alter the quality of their results. In an ISO 15189 accredited laboratory, flexible scope accreditation facilitates the inclusion of these changes prior to accreditation body evaluation. A strategy to perform the validation of a biochemistry analyzer in an accredited laboratory having a flexible scope is shown. Materials and methods: A validation procedure including the evaluation of imprecision and bias of two Dimension Vista analysers 1500 was conducted. Comparability of patient results between one of them and the lately replaced Dimension RxL Max was evaluated. All studies followed the respective Clinical and Laboratory Standards Institute (CLSI) protocols. 30 chemistry assays were studied. Coefficients of variation, percent bias and total error were calculated for all tests and biological variation was considered as acceptance criteria. Quality control material and patient samples were used as test materials. Interchangeability of the results was established by processing forty patients’ samples in both devices. Results: 27 of the 30 studied parameters met allowable performance criteria. Sodium, chloride and magnesium did not fulfil acceptance criteria. Evidence of interchangeability of patient results was obtained for all parameters except magnesium, NT-proBNP, cTroponin I and C-reactive protein. Conclusions: A laboratory having a well structured and documented validation procedure can opt to get a flexible scope of accreditation. In addition, performing these activities prior to use on patient samples may evidence technical issues which must be corrected to minimize their impact on patient results. PMID:23457769

  16. Software Engineering Laboratory Series: Proceedings of the Twenty-First Annual Software Engineering Workshop

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  17. Software Engineering Laboratory Series: Proceedings of the Twenty-Second Annual Software Engineering Workshop

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  18. [Quality Management System in Pathological Laboratory].

    PubMed

    Koyatsu, Junichi; Ueda, Yoshihiko

    2015-07-01

    Even compared to other clinical laboratories, the pathological laboratory conducts troublesome work, and many of the work processes are also manual. Therefore, the introduction of the systematic management of administration is necessary. It will be a shortcut to use existing standards such as ISO 15189 for this purpose. There is no standard specialized for the pathological laboratory, but it is considered to be important to a pathological laboratory in particular. 1. Safety nianagement of the personnel and environmental conditions. Comply with laws and regulations concerning the handling of hazardous materials. 2. Pre-examination processes. The laboratory shall have documented procedures for the proper collection and handling of primary samples. Developed and documented criteria for acceptance or rejection of samples are applied. 3. Examination processes. Selection, verification, and validation of the examination procedures. Devise a system that can constantly monitor the traceability of the sample. 4. Post-examination processes. Storage, retention, and disposal of clinical samples. 5. Release of results. When examination results fall within established alert or critical intervals, immediately notify the physicians. The important point is to recognize the needs of the client and be aware that pathological diagnoses are always "the final diagnoses".

  19. Evaluation of the implementation of a quality system in a basic research laboratory: viability and impacts.

    PubMed

    Fraga, Hilda Carolina de Jesus Rios; Fukutani, Kiyoshi Ferreira; Celes, Fabiana Santana; Barral, Aldina Maria Prado; Oliveira, Camila Indiani de

    2012-01-01

    To evaluate the process of implementing a quality management system in a basic research laboratory of a public institution, particularly considering the feasibility and impacts of this improvement. This was a prospective and qualitative study. We employed the norm "NIT DICLA 035--Princípios das Boas Práticas de Laboratório (BPL)" and auxiliary documents of Organisation for Economic Co-operation and Development to complement the planning and implementation of a Quality System, in a basic research laboratory. In parallel, we used the PDCA tool to define the goals of each phase of the implementation process. This study enabled the laboratory to comply with the NIT DICLA 035 norm and to implement this norm during execution of a research study. Accordingly, documents were prepared and routines were established such as the registration of non-conformities, traceability of research data and equipment calibration. The implementation of a quality system, the setting of a laboratory focused on basic research is feasible once certain structural changes are made. Importantly, impacts were noticed during the process, which could be related to several improvements in the laboratory routine.

  20. Preliminary Thermal Modeling of HI-Storm 100S-218 Version B Storage Modules at Hope Creek Cuclear Power Station ISFSI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cuta, Judith M.; Adkins, Harold E.

    2013-08-30

    As part of the Used Fuel Disposition Campaign of the U. S. Department of Energy, Office of Nuclear Energy (DOE-NE) Fuel Cycle Research and Development, a consortium of national laboratories and industry is performing visual inspections and temperature measurements of selected storage modules at various locations around the United States. This report documents thermal analyses in in support of the inspections at the Hope Creek Nuclear Generating Station ISFSI. This site utilizes the HI-STORM100 vertical storage system developed by Holtec International. This is a vertical storage module design, and the thermal models are being developed using COBRA-SFS (Michener, et al.,more » 1987), a code developed by PNNL for thermal-hydraulic analyses of multi assembly spent fuel storage and transportation systems. This report describes the COBRA-SFS model in detail, and presents pre-inspection predictions of component temperatures and temperature distributions. The final report will include evaluation of inspection results, and if required, additional post-test calculations, with appropriate discussion of results.« less

  1. Shallow subtidal survey of the Washington outer coast and Olympic National park to determine the distribution, fate, and effects of spilled bunker C fuel oil. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carney, D.; Kvitek, R.G.

    1990-12-01

    The report provides an evaluation of the impacts of the bunker C fuel oil spill on the shallow subtidal benthic communities of the Washington coast. The study is designed to provide a subtidal extension of the intertidal investigation performed by Battelle Laboratories. As such, the study sites and many of the methodologies are the same. There are four objectives of the study. They are: (1) to identify and define from existing data, the probable distribution of subtidal deposits along the Washington coast, (2) to document petroleum hydrocarbon contamination in shallow subtidal sediments in the Olympic National Park and along themore » Washington outer coast, (3) to characterize petroleum hydrocarbon contamination in molluscan and other species' tissues of opportunity in subtidal habitats along the Washington outer coast, and (4) to collect the initial faunal and sediment samples required for possible future analyses should oil-spill related hydrocarbons be detected from initial sediment and tissue analyses.« less

  2. Definition and documentation of engineering processes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McDonald, G.W.

    1997-11-01

    This tutorial is an extract of a two-day workshop developed under the auspices of the Quality Engineering Department at Sandia National Laboratories. The presentation starts with basic definitions and addresses why processes should be defined and documented. It covers three primary topics: (1) process considerations and rationale, (2) approach to defining and documenting engineering processes, and (3) an IDEFO model of the process for defining engineering processes.

  3. Impacts Analyses Supporting the National Environmental Policy Act Environmental Assessment for the Resumption of Transient Testing Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schafer, Annette L.; Brown, LLoyd C.; Carathers, David C.

    2014-02-01

    This document contains the analysis details and summary of analyses conducted to evaluate the environmental impacts for the Resumption of Transient Fuel and Materials Testing Program. It provides an assessment of the impacts for the two action alternatives being evaluated in the environmental assessment. These alternatives are (1) resumption of transient testing using the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory (INL) and (2) conducting transient testing using the Annular Core Research Reactor (ACRR) at Sandia National Laboratory in New Mexico (SNL/NM). Analyses are provided for radiologic emissions, other air emissions, soil contamination, and groundwater contamination that couldmore » occur (1) during normal operations, (2) as a result of accidents in one of the facilities, and (3) during transport. It does not include an assessment of the biotic, cultural resources, waste generation, or other impacts that could result from the resumption of transient testing. Analyses were conducted by technical professionals at INL and SNL/NM as noted throughout this report. The analyses are based on bounding radionuclide inventories, with the same inventories used for test materials by both alternatives and different inventories for the TREAT Reactor and ACRR. An upper value on the number of tests was assumed, with a test frequency determined by the realistic turn-around times required between experiments. The estimates provided for impacts during normal operations are based on historical emission rates and projected usage rates; therefore, they are bounding. Estimated doses for members of the public, collocated workers, and facility workers that could be incurred as a result of an accident are very conservative. They do not credit safety systems or administrative procedures (such as evacuation plans or use of personal protective equipment) that could be used to limit worker doses. Doses estimated for transportation are conservative and are based on transport of the bounding radiologic inventory that will be contained in any given test. The transportation analysis assumes all transports will contain the bounding inventory.« less

  4. Screening-Level Ecological Risk Assessment Methods, Revision 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mirenda, Richard J.

    2012-08-16

    This document provides guidance for screening-level assessments of potential adverse impacts to ecological resources from release of environmental contaminants at the Los Alamos National Laboratory (LANL or the Laboratory). The methods presented are based on two objectives, namely: to provide a basis for reaching consensus with regulators, managers, and other interested parties on how to conduct screening-level ecological risk investigations at the Laboratory; and to provide guidance for ecological risk assessors under the Environmental Programs (EP) Directorate. This guidance promotes consistency, rigor, and defensibility in ecological screening investigations and in reporting those investigation results. The purpose of the screening assessmentmore » is to provide information to the risk managers so informed riskmanagement decisions can be made. This document provides examples of recommendations and possible risk-management strategies.« less

  5. Requirement analysis for an electronic laboratory notebook for sustainable data management in biomedical research.

    PubMed

    Menzel, Julia; Weil, Philipp; Bittihn, Philip; Hornung, Daniel; Mathieu, Nadine; Demiroglu, Sara Y

    2013-01-01

    Sustainable data management in biomedical research requires documentation of metadata for all experiments and results. Scientists usually document research data and metadata in laboratory paper notebooks. An electronic laboratory notebook (ELN) can keep metadata linked to research data resulting in a better understanding of the research results, meaning a scientific benefit [1]. Besides other challenges [2], the biggest hurdles for introducing an ELN seem to be usability, file formats, and data entry mechanisms [3] and that many ELNs are assigned to specific research fields such as biology, chemistry, or physics [4]. We aimed to identify requirements for the introduction of ELN software in a biomedical collaborative research center [5] consisting of different scientific fields and to find software fulfilling most of these requirements.

  6. Publications of the JPL Solar Thermal Power Systems Project 1976 Through 1985

    NASA Technical Reports Server (NTRS)

    Panda, P. (Compiler); Gray, V. (Compiler); Marsh, C. (Compiler)

    1985-01-01

    Bibliographical listings are documentation products associated with the Solar Thermal Power Systems Project carried out by the Jet Propulsion Laboratory from 1976 to 1986. Documents are categorized as conference and journal papers, JPL external reports, JPL internal reports, or contractor reports (i.e., deliverable documents produced under contract to JPL). Alphabetical listings by titles are used in the bibliography itself to facilitate location of the document by subject. Two indexes are included for ease of reference; an author index; and a topical index.

  7. Wake Turbulence Mitigation for Departures (WTMD) Prototype System - Software Design Document

    NASA Technical Reports Server (NTRS)

    Sturdy, James L.

    2008-01-01

    This document describes the software design of a prototype Wake Turbulence Mitigation for Departures (WTMD) system that was evaluated in shadow mode operation at the Saint Louis (KSTL) and Houston (KIAH) airports. This document describes the software that provides the system framework, communications, user displays, and hosts the Wind Forecasting Algorithm (WFA) software developed by the M.I.T. Lincoln Laboratory (MIT-LL). The WFA algorithms and software are described in a separate document produced by MIT-LL.

  8. International Society for the Advancement of Cytometry Cell Sorter Biosafety Standards

    PubMed Central

    Holmes, Kevin L.; Fontes, Benjamin; Hogarth, Philip; Konz, Richard; Monard, Simon; Pletcher, Charles H.; Wadley, Robert B.; Schmid, Ingrid; Perfetto, Stephen P.

    2014-01-01

    Flow cytometric cell sorting of biological specimens has become prevalent in basic and clinical research laboratories. These specimens may contain known or unknown infectious agents, necessitating precautions to protect instrument operators and the environment from biohazards arising from the use of sorters. To this end the International Society of Analytical Cytology (ISAC) was proactive in establishing biosafety guidelines in 1997 (Schmid et al., Cytometry 1997;28:99–117) and subsequently published revised biosafety standards for cell sorting of unfixed samples in 2007 (Schmid et al., Cytometry Part A J Int Soc Anal Cytol 2007;71A:414–437). Since their publication, these documents have become recognized worldwide as the standard of practice and safety precautions for laboratories performing cell sorting experiments. However, the field of cytometry has progressed since 2007, and the document requires an update. The new Standards provides guidance: (1) for laboratory design for cell sorter laboratories; (2) for the creation of laboratory or instrument specific Standard Operating Procedures (SOP); and (3) on procedures for the safe operation of cell sorters, including personal protective equipment (PPE) and validation of aerosol containment. PMID:24634405

  9. 75 FR 10252 - Release of Draft Documents Related to the Review of the National Ambient Air Quality Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    .... This draft document describes the quantitative analyses that are being conducted as part of the review... primary (health-based) CO NAAQS, the Agency is conducting qualitative and quantitative assessments... results, observations, and related uncertainties associated with the quantitative analyses performed. An...

  10. Autobody Technology Curriculum Guide.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This Idaho state curriculum guide provides lists of tasks, performance objectives, and enabling objectives for instruction in auto body technology. Following a curriculum framework that explains major content, laboratory activities, and intended outcomes, the document lists all tasks covered in the curriculum. The bulk of the document consists of…

  11. NHEXAS PHASE I MARYLAND STUDY--LIST OF AVAILABLE DOCUMENTS: PROTOCOLS AND SOPS

    EPA Science Inventory

    This document lists available protocols and SOPs for the NHEXAS Phase I Maryland study. It identifies protocols and SOPs for the following study components: (1) Sample collection and field operations, (2) Sample analysis and general laboratory procedures, (3) Data Analysis Proced...

  12. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... quality control elements, where applicable, into the laboratory's documented standard operating procedure... quality control elements must be clearly documented in the written standard operating procedure for each... Methods contains QA/QC procedures in the Part 1000 section of the Standard Methods Compendium. The...

  13. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... quality control elements, where applicable, into the laboratory's documented standard operating procedure... quality control elements must be clearly documented in the written standard operating procedure for each... Methods contains QA/QC procedures in the Part 1000 section of the Standard Methods Compendium. The...

  14. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... quality control elements, where applicable, into the laboratory's documented standard operating procedure... quality control elements must be clearly documented in the written standard operating procedure for each... Methods contains QA/QC procedures in the Part 1000 section of the Standard Methods Compendium. The...

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goldsmith, John E. M.; Brennan, James S.; Brubaker, Erik

    A wide range of NSC (Neutron Scatter Camera) activities were conducted under this lifecycle plan. This document outlines the highlights of those activities, broadly characterized as system improvements, laboratory measurements, and deployments, and presents sample results in these areas. Additional information can be found in the documents that reside in WebPMIS.

  16. Cloud computing strategic framework (FY13 - FY15).

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arellano, Lawrence R.; Arroyo, Steven C.; Giese, Gerald J.

    This document presents an architectural framework (plan) and roadmap for the implementation of a robust Cloud Computing capability at Sandia National Laboratories. It is intended to be a living document and serve as the basis for detailed implementation plans, project proposals and strategic investment requests.

  17. BASIC Instructional Program: System Documentation.

    ERIC Educational Resources Information Center

    Dageforde, Mary L.

    This report documents the BASIC Instructional Program (BIP), a "hands-on laboratory" that teaches elementary programming in the BASIC language, as implemented in the MAINSAIL language, a machine-independent revision of SAIL which should facilitate implementation of BIP on other computing systems. Eight instructional modules which make up…

  18. ANAB, Certification and Scope of Accreditation (ISO/IEC 17025:2005) for the National Vehicle and Fuel Emissions Laboratory

    EPA Pesticide Factsheets

    This document certifies that the EPA National Vehicle and Fuel Emissions Laboratory has been assessed by the ANSI-ASQ National Accredation Board and accredited in meeting ISO-IEC 17025:2005 quality standards.

  19. Region 7 Laboratory Information Management System

    EPA Pesticide Factsheets

    This is metadata documentation for the Region 7 Laboratory Information Management System (R7LIMS) which maintains records for the Regional Laboratory. Any Laboratory analytical work performed is stored in this system which replaces LIMS-Lite, and before that LAST. The EPA and its contractors may use this database. The Office of Policy & Management (PLMG) Division at EPA Region 7 is the primary managing entity; contractors can access this database but it is not accessible to the public.

  20. Software to Manage the Unmanageable

    NASA Technical Reports Server (NTRS)

    2005-01-01

    In 1995, NASA s Jet Propulsion Laboratory (JPL) contracted Redmond, Washington-based Lucidoc Corporation, to design a technology infrastructure to automate the intersection between policy management and operations management with advanced software that automates document workflow, document status, and uniformity of document layout. JPL had very specific parameters for the software. It expected to store and catalog over 8,000 technical and procedural documents integrated with hundreds of processes. The project ended in 2000, but NASA still uses the resulting highly secure document management system, and Lucidoc has managed to help other organizations, large and small, with integrating document flow and operations management to ensure a compliance-ready culture.

  1. Data collection procedures for the Software Engineering Laboratory (SEL) database

    NASA Technical Reports Server (NTRS)

    Heller, Gerard; Valett, Jon; Wild, Mary

    1992-01-01

    This document is a guidebook to collecting software engineering data on software development and maintenance efforts, as practiced in the Software Engineering Laboratory (SEL). It supersedes the document entitled Data Collection Procedures for the Rehosted SEL Database, number SEL-87-008 in the SEL series, which was published in October 1987. It presents procedures to be followed on software development and maintenance projects in the Flight Dynamics Division (FDD) of Goddard Space Flight Center (GSFC) for collecting data in support of SEL software engineering research activities. These procedures include detailed instructions for the completion and submission of SEL data collection forms.

  2. The Desert Laboratory Repeat Photography Collection - An Invaluable Archive Documenting Landscape Change

    USGS Publications Warehouse

    Webb, Robert H.; Boyer, Diane E.; Turner, Raymond M.; Bullock, Stephen H.

    2007-01-01

    The Desert Laboratory Repeat Photography Collection, the largest collection of its kind in the world, is housed at the U.S. Geological Survey (USGS) in Tucson, Arizona. The collection preserves thousands of photos taken precisely in the same places but at different times. This archive of 'repeat photographs' documents changes in the desert landscape and vegetation of the American Southwest, and also includes images from northwestern Mexico and Kenya. These images are an invaluable asset to help understand the effects of climate variation and land-use practices on arid and semiarid environments.

  3. Universal computer test stand (recommended computer test requirements). [for space shuttle computer evaluation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Techniques are considered which would be used to characterize areospace computers with the space shuttle application as end usage. The system level digital problems which have been encountered and documented are surveyed. From the large cross section of tests, an optimum set is recommended that has a high probability of discovering documented system level digital problems within laboratory environments. Defined is a baseline hardware, software system which is required as a laboratory tool to test aerospace computers. Hardware and software baselines and additions necessary to interface the UTE to aerospace computers for test purposes are outlined.

  4. Apollo 16 photographic standards documentation

    NASA Technical Reports Server (NTRS)

    Bourque, P. F.

    1972-01-01

    The activities of the Photographic Technology Division, and particularly the Photo Science Office, the Precision Processing Laboratory, and the Motion Picture Laboratory, in connection with the scientific photography of the Apollo 16 manned space mission are documented. Described are the preflight activities involved in establishing a standard process for each of the flight films, the manned in which flight films were handled upon arrival at the Manned Spacecraft Center in Houston, Texas, and how the flight films were processed and duplicated. The tone reproduction method of duplication is described. The specific sensitometric and chemical process controls are not included.

  5. Idaho National Laboratory Cultural Resource Management Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Julie Braun Williams

    As a federal agency, the U.S. Department of Energy has been directed by Congress, the U.S. president, and the American public to provide leadership in the preservation of prehistoric, historic, and other cultural resources on the lands it administers. This mandate to preserve cultural resources in a spirit of stewardship for the future is outlined in various federal preservation laws, regulations, and guidelines such as the National Historic Preservation Act, the Archaeological Resources Protection Act, and the National Environmental Policy Act. The purpose of this Cultural Resource Management Plan is to describe how the Department of Energy, Idaho Operations Officemore » will meet these responsibilities at Idaho National Laboratory in southeastern Idaho. The Idaho National Laboratory is home to a wide variety of important cultural resources representing at least 13,500 years of human occupation in the southeastern Idaho area. These resources are nonrenewable, bear valuable physical and intangible legacies, and yield important information about the past, present, and perhaps the future. There are special challenges associated with balancing the preservation of these sites with the management and ongoing operation of an active scientific laboratory. The Department of Energy, Idaho Operations Office is committed to a cultural resource management program that accepts these challenges in a manner reflecting both the spirit and intent of the legislative mandates. This document is designed for multiple uses and is intended to be flexible and responsive to future changes in law or mission. Document flexibility and responsiveness will be assured through regular reviews and as-needed updates. Document content includes summaries of Laboratory cultural resource philosophy and overall Department of Energy policy; brief contextual overviews of Laboratory missions, environment, and cultural history; and an overview of cultural resource management practices. A series of appendices provides important details that support the main text.« less

  6. International Society for Analytical Cytology biosafety standard for sorting of unfixed cells.

    PubMed

    Schmid, Ingrid; Lambert, Claude; Ambrozak, David; Marti, Gerald E; Moss, Delynn M; Perfetto, Stephen P

    2007-06-01

    Cell sorting of viable biological specimens has become very prevalent in laboratories involved in basic and clinical research. As these samples can contain infectious agents, precautions to protect instrument operators and the environment from hazards arising from the use of sorters are paramount. To this end the International Society of Analytical Cytology (ISAC) took a lead in establishing biosafety guidelines for sorting of unfixed cells (Schmid et al., Cytometry 1997;28:99-117). During the time period these recommendations have been available, they have become recognized worldwide as the standard practices and safety precautions for laboratories performing viable cell sorting experiments. However, the field of cytometry has progressed since 1997, and the document requires an update. Initially, suggestions about the document format and content were discussed among members of the ISAC Biosafety Committee and were incorporated into a draft version that was sent to all committee members for review. Comments were collected, carefully considered, and incorporated as appropriate into a draft document that was posted on the ISAC web site to invite comments from the flow cytometry community at large. The revised document was then submitted to ISAC Council for review. Simultaneously, further comments were sought from newly-appointed ISAC Biosafety committee members. This safety standard for performing viable cell sorting experiments was recently generated. The document contains background information on the biohazard potential of sorting and the hazard classification of infectious agents as well as recommendations on (1) sample handling, (2) operator training and personal protection, (3) laboratory design, (4) cell sorter set-up, maintenance, and decontamination, and (5) testing the instrument for the efficiency of aerosol containment. This standard constitutes an updated and expanded revision of the 1997 biosafety guideline document. It is intended to provide laboratories involved in cell sorting with safety practices that take into account the enhanced hazard potential of high-speed sorting. Most importantly, it states that droplet-based sorting of infectious or hazardous biological material requires a higher level of containment than the one recommended for the risk group classification of the pathogen. The document also provides information on safety features of novel instrumentation, new options for personal protective equipment, and recently developed methods for testing the efficiency of aerosol containment.

  7. Energy and Environmental Issues in Eastern Europe and Central Asia: An Annotated Guide to Information Resources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gant, K.S.

    2000-10-09

    Energy and environmental problems undermine the potential for sustained economic development and contribute to political and economic instability in the strategically important region surrounding the Caspian and Black Seas. Many organizations supporting efforts to resolve problems in this region have found that consensus building--a prerequisite for action--is a difficult process. Reaching agreement on priorities for investment, technical collaboration, and policy incentives depends upon informed decision-making by governments and local stakeholders. And while vast quantities of data and numerous analyses and reports are more accessible than ever, wading through the many potential sources in search of timely and relevant data ismore » a formidable task. To facilitate more successful data searches and retrieval, this document provides annotated references to over 200 specific information sources, and over twenty primary search engines and data retrieval services, that provide relevant and timely information related to the environment, energy, and economic development around the Caspian and Black Seas. This document is an advance copy of the content that Oak Ridge National Laboratory (ORNL) plans to transfer to the web in HTML format to facilitate interactive search and retrieval of information using standard web-browser software.« less

  8. International Organization for Standardization (ISO) 15189.

    PubMed

    Schneider, Frank; Maurer, Caroline; Friedberg, Richard C

    2017-09-01

    The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international organization for standardization (ISO) 15189 standard for quality management specific to medical laboratories. CAP leaders offer an overview of ISO 15189 including its components, internal audits, occurrence management, document control, and risk management. The authors provide a comparison of its own ISO 15189 program, CAP 15189, to the CAP Laboratory Accreditation Program. The authors conclude with why laboratories should use ISO 15189. © The Korean Society for Laboratory Medicine.

  9. Design criteria for the light duty utility arm system end effectors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pardini, A.F.; Kiebel, G.R.

    1995-12-01

    The purpose of this document is to provide criteria for the design of end effectors that will be used as part of the Light Duty Utility Arm (LDUA) System. Actual component design, fabrication, testing, and inspection will be performed by various DOE laboratories, industry, and academia. This document augments WHC-SD-TD-FRD-003, `Functions and Requirements for the Light Duty Utility Arm Integrated System` (F). All requirements dictated in the F shall also be applicable in this document. Whenever conflicts arise between this document and the F, this document shall take precedence.

  10. Abbreviations, acronyms, and initialisms frequently used by Martin Marietta Energy Systems, Inc.. Second edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, J.T.

    1994-09-01

    Guidelines are given for using abbreviations, acronyms, and initialisms (AAIs) in documents prepared by US Department of Energy facilities managed by Martin Marietta Energy Systems, Inc., in Oak Ridge, Tennessee. The more than 10,000 AAIs listed represent only a small portion of those found in recent documents prepared by contributing editors of the Information Management Services organization of Oak Ridge National Laboratory, the Oak Ridge K-25 Site, and the Oak Ridge Y-12 Plant. This document expands on AAIs listed in the Document Preparation Guide and is intended as a companion document

  11. The JPL Library information retrieval system

    NASA Technical Reports Server (NTRS)

    Walsh, J.

    1975-01-01

    The development, capabilities, and products of the computer-based retrieval system of the Jet Propulsion Laboratory Library are described. The system handles books and documents, produces a book catalog, and provides a machine search capability. Programs and documentation are available to the public through NASA's computer software dissemination program.

  12. Use of a Digital Camera To Document Student Observations in a Microbiology Laboratory Class.

    ERIC Educational Resources Information Center

    Mills, David A.; Kelley, Kevin; Jones, Michael

    2001-01-01

    Points out the lack of microscopic images of wine-related microbes. Uses a digital camera during a wine microbiology laboratory to capture student-generated microscope images. Discusses the advantages of using a digital camera in a teaching lab. (YDS)

  13. Cocaine Use among the College Age Group: Biological and Psychological Effects--Clinical and Laboratory Research Findings.

    ERIC Educational Resources Information Center

    Nicholi, Armand M., Jr.

    1984-01-01

    Knowledge about cocaine's effect on the human mind and body is limited and not clearly documented. This article discusses various biological and psychological effects of the drug based on clinical and laboratory studies of man. (Author/DF)

  14. Environmental testing philosophy for a Sandia National Laboratories small satellite project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cap, J.S.; Rackley, N.G.

    1996-03-01

    Sandia National Laboratories is the system integrator on a small satellite project. Following the intent of the NASA GEVS document, an integrated test philosophy was formulated to certify the satellite for flight. The purpose of this paper is to present that philosophy.

  15. 10 More States Enact Laws on Vandalizing Animal Laboratories.

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    1991-01-01

    Twenty-two states now specifically outlaw such activities as entering a research laboratory without permission, releasing animals, disrupting experiments, and removing documents and photographs related to research. Several expand the definition of criminal activity to include videotaping or photographing facility interiors. Penalties vary by…

  16. Methods and Metrics for Evaluating Environmental Dredging at the Ashtabula River Area of Concern (AOC)

    EPA Science Inventory

    This report documents the objectives, approach, methodologies, results, and interpretation of a collaborative research study conducted by the National Risk Management Research Laboratory (NRMRL) and the National Exposure Research laboratory (NERL) of the U.S. Environmental Prote...

  17. Guidance for Human Subjects Research in the National Exposure Research Laboratory

    EPA Science Inventory

    This document provides guidance to investigators and managers associated with the U.S. Environmental Protection Agency (EPA) Office of Research and Development (ORD)’s National Exposure Research Laboratory (NERL) on the ethical conduct, regulatory review, and approval of all huma...

  18. Los Alamos Scientific Laboratory energy-related history, research, managerial reorganization proposals, actions taken, and results. History report, 1945--1979

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hammel, E.F.

    1997-03-01

    This report documents the development of major energy-related programs at the Los Alamos Scientific Laboratory between 1945 and 1979. Although the Laboratory`s primary mission during that era was the design and development of nuclear weapons and most of the Laboratory`s funding came from a single source, a number of factors were at work that led to the development of these other programs. Some of those factors were affected by the Laboratory`s internal management structure and organization; others were the result of increasing environmental awareness within the general population and the political consequences of that awareness; still others were related tomore » the increasing demand for energy and the increasing turmoil in the energy-rich Middle East. This report also describes the various activities in Los Alamos, in Washington, and in other areas of the world that contributed to the development of major energy-related programs at Los Alamos. The author has a unique historical perspective because of his involvement as a scientist and manager at the Los Alamos Scientific Laboratory during the time period described within the report. In addition, in numerous footnotes and references, he cites a large body of documents that include the opinions and perspectives of many others who were involved at one time or another in these programs. Finally the report includes a detailed chronology of geopolitical events that led to the development of energy-related programs at Los Alamos.« less

  19. Quality assurance and quality control in light stable isotope laboratories: A case study of Rio Grande, Texas, water samples

    USGS Publications Warehouse

    Coplen, T.B.; Qi, H.

    2009-01-01

    New isotope laboratories can achieve the goal of reporting the same isotopic composition within analytical uncertainty for the same material analysed decades apart by (1) writing their own acceptance testing procedures and putting them into their mass spectrometric or laser-based isotope-ratio equipment procurement contract, (2) requiring a manufacturer to demonstrate acceptable performance using all sample ports provided with the instrumentation, (3) for each medium to be analysed, prepare two local reference materials substantially different in isotopic composition to encompass the range in isotopic composition expected in the laboratory and calibrated them with isotopic reference materials available from the International Atomic Energy Agency (IAEA) or the US National Institute of Standards and Technology (NIST), (4) using the optimum storage containers (for water samples, sealing in glass ampoules that are sterilised after sealing is satisfactory), (5) interspersing among sample unknowns local laboratory isotopic reference materials daily (internationally distributed isotopic reference materials can be ordered at three-year intervals, and can be used for elemental analyser analyses and other analyses that consume less than 1 mg of material) - this process applies to H, C, N, O, and S isotope ratios, (6) calculating isotopic compositions of unknowns by normalising isotopic data to that of local reference materials, which have been calibrated to internationally distributed isotopic reference materials, (7) reporting results on scales normalised to internationally distributed isotopic reference materials (where they are available) and providing to sample submitters the isotopic compositions of internationally distributed isotopic reference materials of the same substance had they been analysed with unknowns, (8) providing an audit trail in the laboratory for analytical results - this trail commonly will be in electronic format and might include a laboratory information management system, (9) making at regular intervals a complete backup of laboratory analytical data (both of samples logged into the laboratory and of mass spectrometric analyses), being sure to store one copy of this backup offsite, and (10) participating in interlaboratory comparison exercises sponsored by the IAEA and other agencies at regular intervals. ?? Taylor & Francis.

  20. ISO 15189 accreditation: Requirements for quality and competence of medical laboratories, experience of a laboratory I.

    PubMed

    Guzel, Omer; Guner, Ebru Ilhan

    2009-03-01

    Medical laboratories are the key partners in patient safety. Laboratory results influence 70% of medical diagnoses. Quality of laboratory service is the major factor which directly affects the quality of health care. The clinical laboratory as a whole has to provide the best patient care promoting excellence. International Standard ISO 15189, based upon ISO 17025 and ISO 9001 standards, provides requirements for competence and quality of medical laboratories. Accredited medical laboratories enhance credibility and competency of their testing services. Our group of laboratories, one of the leading institutions in the area, had previous experience with ISO 9001 and ISO 17025 Accreditation at non-medical sections. We started to prepared for ISO 15189 Accreditation at the beginning of 2006 and were certified in March, 2007. We spent more than a year to prepare for accreditation. Accreditation scopes of our laboratory were as follows: clinical chemistry, hematology, immunology, allergology, microbiology, parasitology, molecular biology of infection serology and transfusion medicine. The total number of accredited tests is 531. We participate in five different PT programs. Inter Laboratory Comparison (ILC) protocols are performed with reputable laboratories. 82 different PT Program modules, 277 cycles per year for 451 tests and 72 ILC program organizations for remaining tests have been performed. Our laboratory also organizes a PT program for flow cytometry. 22 laboratories participate in this program, 2 cycles per year. Our laboratory has had its own custom made WEB based LIS system since 2001. We serve more than 500 customers on a real time basis. Our quality management system is also documented and processed electronically, Document Management System (DMS), via our intranet. Preparatory phase for accreditation, data management, external quality control programs, personnel related issues before, during and after accreditation process are presented. Every laboratory has to concentrate on patient safety issues related to laboratory testing and should perform quality improvement projects.

  1. 7 CFR 1717.1204 - Policies and conditions applicable to settlements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and records; and (v) All analyses, studies, opinions, memoranda, and other documents and information... to meet its financial obligations will be based on analyses and documentation by RUS of the borrower... satisfactory to RUS, an in-depth analysis supporting the borrower's contention that it is unable or will not be...

  2. International Organization for Standardization (ISO) 15189

    PubMed Central

    Schneider, Frank; Friedberg, Richard C.

    2017-01-01

    The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international organization for standardization (ISO) 15189 standard for quality management specific to medical laboratories. CAP leaders offer an overview of ISO 15189 including its components, internal audits, occurrence management, document control, and risk management. The authors provide a comparison of its own ISO 15189 program, CAP 15189, to the CAP Laboratory Accreditation Program. The authors conclude with why laboratories should use ISO 15189. PMID:28643484

  3. Petroleum storage tank cleaning using commercial microbial culture products

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schneider, D.R.; Entzeroth, L.C.; Timmis, A.

    1995-12-31

    The removal of paraffinic bottom accumulations from refinery storage tanks represents an increasingly costly area of petroleum storage management. Microorganisms can be used to reduce paraffinic bottoms by increasing the solubility of bottom material and by increasing the wax-carrying capacity of carrier oil used in the cleaning process. The economic savings of such treatments are considerable. The process is also intrinsically safer than alternative methods, as it reduces and even eliminates the need for personnel to enter the tank during the cleaning process. Both laboratory and field sample analyses can be used to document changes in tank material during themore » treatment process. These changes include increases in volatile content and changes in wax distribution. Several case histories illustrating these physical and chemical changes are presented along with the economics of treatment.« less

  4. Characterization of Three Carbon- and Nitrogen-Rich Particles from Comet 81P/WILD

    NASA Technical Reports Server (NTRS)

    Gallien, J.-P.; Khodja, H.; Herzog, G. F.; Taylor, S.; Koepsell, E.; Daghlian, C. P.; Flynn, G. J.; Sitnitsky, I.; Lanzirotti, A.; Sutton, S. R.; hide

    2007-01-01

    Comets may sample the early solar system s complement of volatile-forming elements - including C and N - more fully and reliably than do the terrestrial planets or asteroids. Until recently, all elemental analyses of unambiguously cometary material were carried out remotely. The return of the Stardust mission makes it possible to analyze documented material from P81/Wild 2 in the laboratory Wild 2 particles fragmented when they stopped in the aerogel collectors. We have studied three fragments thought to be rich in C and N by using several techniques: FTIR to characterize organic matter; synchrotron-induced x-ray fluorescence (SXRF) to determine Fe and certain element/Fe ratios; SEM to image sample morphology and to detect semiquantitatively Mg, Al, Si, Ca, and Fe; and nuclear reaction analysis (NRA) to measure C, N, O, and Si.

  5. Health check documentation of psychosocial factors using the WAI.

    PubMed

    Uronen, L; Heimonen, J; Puukka, P; Martimo, K-P; Hartiala, J; Salanterä, S

    2017-03-01

    Health checks in occupational health (OH) care should prevent deterioration of work ability and promote well-being at work. Documentation of health checks should reflect and support continuity of prevention and practice. To analyse how OH nurses (OHNs) undertaking health checks document psychosocial factors at work and use the Work Ability Index (WAI). Analysis of two consecutive OHN health check records and WAI scores with statistical analyses and annotations of 13 psychosocial factors based on a publicly available standard on psychosocial risk management: British Standards Institution specification PAS 1010, part of European Council Directive 89/391/EEC, with a special focus on work-related stress and workplace violence. We analysed health check records for 196 employees. The most frequently documented psychosocial risk factors were home-work interface, work environment and equipment, job content, workload and work pace and work schedule. The correlations between the number of documented risk and non-risk factors and WAI scores were significant: OHNs documented more risk factors in employees with lower WAI scores. However, documented psychosocial risk factors were not followed up, and the OHNs' most common response to detected psychosocial risks was an appointment with a physician. The number of psychosocial risk factors documented by OHNs correlated with subjects' WAI scores. However, the documentation was not systematic and the interventions were not always relevant. OHNs need a structure to document psychosocial factors and more guidance in how to use the documentation as a tool in their decision making in health checks. © The Author 2016. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  6. Arctic Climate Systems Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ivey, Mark D.; Robinson, David G.; Boslough, Mark B.

    2015-03-01

    This study began with a challenge from program area managers at Sandia National Laboratories to technical staff in the energy, climate, and infrastructure security areas: apply a systems-level perspective to existing science and technology program areas in order to determine technology gaps, identify new technical capabilities at Sandia that could be applied to these areas, and identify opportunities for innovation. The Arctic was selected as one of these areas for systems level analyses, and this report documents the results. In this study, an emphasis was placed on the arctic atmosphere since Sandia has been active in atmospheric research in themore » Arctic since 1997. This study begins with a discussion of the challenges and benefits of analyzing the Arctic as a system. It goes on to discuss current and future needs of the defense, scientific, energy, and intelligence communities for more comprehensive data products related to the Arctic; assess the current state of atmospheric measurement resources available for the Arctic; and explain how the capabilities at Sandia National Laboratories can be used to address the identified technological, data, and modeling needs of the defense, scientific, energy, and intelligence communities for Arctic support.« less

  7. Scrub typhus: audit of an outbreak.

    PubMed

    Krishna, Mani Ram; Vasuki, B; Nagaraju, K

    2015-06-01

    To document the epidemiological, clinical and laboratory profile of all children with scrub typhus at a tertiary care centre in Chennai between September 2010 and June 2011. The case records of all children admitted and diagnosed with scrub typhus between September 2010 and June 2011 were analysed to look for salient clinical and laboratory parameters. During the study period, 52 children were admitted with scrub typhus in the authors' hospital. The presenting complaints included fever in all cases. Other symptoms included swelling of legs (50 %) and vomiting (45 %). 13 % presented with CNS symptoms. The commonest physical findings included eschar (67 %), hepatomegaly (94 %), splenomegaly (73 %) and third spacing (67 %). Salient lab parameters included packed cell volume (PCV) <30 (48 %), leucocytosis (56 %), positive C-reactive protein (CRP) (92 %), hypoalbuminemia (79 %). Common complications included acute kidney injury (10 %) and peripheral gangrene (4 %). There was no mortality in the present case series. The clinical profile of children with scrub typhus in a tertiary care centre is reported. Eschar and hepatosplenomegaly with a high CRP value is helpful in diagnosis. All patients responded well to the treatment.

  8. Cross-Shear Implementation in Sliding-Distance-Coupled Finite Element Analysis of Wear in Metal-on-Polyethylene Total Joint Arthroplasty: Intervertebral Total Disc Replacement as an Illustrative Application

    PubMed Central

    Goreham-Voss, Curtis M.; Hyde, Philip J.; Hall, Richard M.; Fisher, John; Brown, Thomas D.

    2010-01-01

    Computational simulations of wear of orthopaedic total joint replacement implants have proven to valuably complement laboratory physical simulators, for pre-clinical estimation of abrasive/adhesive wear propensity. This class of numerical formulations has primarily involved implementation of the Archard/Lancaster relationship, with local wear computed as the product of (finite element) contact stress, sliding speed, and a bearing-couple-dependent wear factor. The present study introduces an augmentation, whereby the influence of interface cross-shearing motion transverse to the prevailing molecular orientation of the polyethylene articular surface is taken into account in assigning the instantaneous local wear factor. The formulation augment is implemented within a widely-utilized commercial finite element software environment (ABAQUS). Using a contemporary metal-on-polyethylene total disc replacement (ProDisc-L) as an illustrative implant, physically validated computational results are presented to document the role of cross-shearing effects in alternative laboratory consensus testing protocols. Going forward, this formulation permits systematically accounting for cross-shear effects in parametric computational wear studies of metal-on-polyethylene joint replacements, heretofore a substantial limitation of such analyses. PMID:20399432

  9. Comparison of the uncertainties of several European low-dose calibration facilities

    NASA Astrophysics Data System (ADS)

    Dombrowski, H.; Cornejo Díaz, N. A.; Toni, M. P.; Mihelic, M.; Röttger, A.

    2018-04-01

    The typical uncertainty of a low-dose rate calibration of a detector, which is calibrated in a dedicated secondary national calibration laboratory, is investigated, including measurements in the photon field of metrology institutes. Calibrations at low ambient dose equivalent rates (at the level of the natural ambient radiation) are needed when environmental radiation monitors are to be characterised. The uncertainties of calibration measurements in conventional irradiation facilities above ground are compared with those obtained in a low-dose rate irradiation facility located deep underground. Four laboratories quantitatively evaluated the uncertainties of their calibration facilities, in particular for calibrations at low dose rates (250 nSv/h and 1 μSv/h). For the first time, typical uncertainties of European calibration facilities are documented in a comparison and the main sources of uncertainty are revealed. All sources of uncertainties are analysed, including the irradiation geometry, scattering, deviations of real spectra from standardised spectra, etc. As a fundamental metrological consequence, no instrument calibrated in such a facility can have a lower total uncertainty in subsequent measurements. For the first time, the need to perform calibrations at very low dose rates (< 100 nSv/h) deep underground is underpinned on the basis of quantitative data.

  10. Type A Accident Investigation Board report on the January 17, 1996, electrical accident with injury in Technical Area 21 Tritium Science and Fabrication Facility Los Alamos National Laboratory. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-04-01

    An electrical accident was investigated in which a crafts person received serious injuries as a result of coming into contact with a 13.2 kilovolt (kV) electrical cable in the basement of Building 209 in Technical Area 21 (TA-21-209) in the Tritium Science and Fabrication Facility (TSFF) at Los Alamos National Laboratory (LANL). In conducting its investigation, the Accident Investigation Board used various analytical techniques, including events and causal factor analysis, barrier analysis, change analysis, fault tree analysis, materials analysis, and root cause analysis. The board inspected the accident site, reviewed events surrounding the accident, conducted extensive interviews and document reviews,more » and performed causation analyses to determine the factors that contributed to the accident, including any management system deficiencies. Relevant management systems and factors that could have contributed to the accident were evaluated in accordance with the guiding principles of safety management identified by the Secretary of Energy in an October 1994 letter to the Defense Nuclear Facilities Safety Board and subsequently to Congress.« less

  11. Space Sciences Laboratory Publications and Presentations

    NASA Technical Reports Server (NTRS)

    Summers, F. G. (Compiler)

    1998-01-01

    This document lists the significant publications and presentations of the Space Sciences Laboratory during the period January 1 - December 31, 1997. Entries in the main part of the document are categorized according to NASA Reports (arranged by report number), Open Literature, and Presentations (arranged alphabetically by title). Also included for completeness is an Appendix (arranged by page number) listing preprints issued by the Laboratory during this reporting period. Some of the preprints have not been published; those already published are so indicated. Most of the articles listed under Open Literature have appeared in refereed professional journals, books, monographs, or conference proceedings. Although many published abstracts are eventually expanded into full papers for publication in scientific and technical journals, they are often sufficiently comprehensive to include the significant results of the research reported. Therefore, published abstracts are listed separately in a subsection under Open Literature.

  12. WHO Expert Committee on Specifications for Pharmaceutical Preparations.

    PubMed

    2011-01-01

    The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines. Standards are developed by the Committee through worldwide consultation and an international consensus-building process. The following new guidelines were adopted and recommended for use: procedure for adoption of International Chemical Reference Substances; WHO good practices for pharmaceutical microbiology laboratories; good manufacturing practices: main principles for pharmaceutical products; good manufacturing practices for blood establishments (jointly with the Expert Committee on Biological Standardization); guidelines on good manufacturing practices for heating, ventilation and air-conditioning systems for non-sterile pharmaceutical dosage forms; good manufacturing practices for sterile pharmaceutical products; guidelines on transfer of technology in pharmaceutical manufacturing; good pharmacy practice: standards for quality of pharmacy services (joint FIP/WHO); model guidance for the storage and transport of time- and temperature-sensitive pharmaceutical products (jointly with the Expert Committee on Biological Standardization); procedure for prequalification of pharmaceutical products; guide on submission of documentation for prequalification of innovator finished pharmaceutical products approved by stringent regulatory authorities; prequalification of quality control laboratories: procedure for assessing the acceptability, in principle, of quality control laboratories for use by United Nations agencies; guidelines for preparing a laboratory information file; guidelines for drafting a site master file; guidelines on submission of documentation for a multisource (generic) finished product: general format: preparation of product dossiers in common technical document format.

  13. National Health Care Skill Standards.

    ERIC Educational Resources Information Center

    National Consortium on Health Science and Technology Education, Okemos, MI.

    This document presents the National Health Care Skill Standards, which were developed by the National Consortium on Health Science and Technology and West Ed Regional Research Laboratory, in partnership with educators and health care employers. The document begins with an overview of the purpose and benefits of skill standards. Presented next are…

  14. Shell Games. VORTEX: Virginia's Oyster Reef Teaching EXperience.

    ERIC Educational Resources Information Center

    Harding, Juliana M.; Mann, Roger; Clark, Vicki P.

    This document introduces Virginia's Oyster Reef Teaching EXperience (VORTEX), which is an interdisciplinary program focusing on the importance of oyster reef communities in the Chesapeake Bay ecosystem. The VORTEX program uses field and laboratory experiences supported by multimedia instruction. This document presents an overview on the biology of…

  15. 21 CFR 866.4700 - Automated fluorescence in situ hybridization (FISH) enumeration systems.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Automated fluorescence in situ hybridization (FISH... Laboratory Equipment and Reagents § 866.4700 Automated fluorescence in situ hybridization (FISH) enumeration... document entitled “Class II Special Controls Guidance Document: Automated Fluorescence in situ...

  16. 21 CFR 866.4700 - Automated fluorescence in situ hybridization (FISH) enumeration systems.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Automated fluorescence in situ hybridization (FISH... Laboratory Equipment and Reagents § 866.4700 Automated fluorescence in situ hybridization (FISH) enumeration... document entitled “Class II Special Controls Guidance Document: Automated Fluorescence in situ...

  17. 21 CFR 866.4700 - Automated fluorescence in situ hybridization (FISH) enumeration systems.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Automated fluorescence in situ hybridization (FISH... Laboratory Equipment and Reagents § 866.4700 Automated fluorescence in situ hybridization (FISH) enumeration... document entitled “Class II Special Controls Guidance Document: Automated Fluorescence in situ...

  18. 21 CFR 866.4700 - Automated fluorescence in situ hybridization (FISH) enumeration systems.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Automated fluorescence in situ hybridization (FISH... Laboratory Equipment and Reagents § 866.4700 Automated fluorescence in situ hybridization (FISH) enumeration... document entitled “Class II Special Controls Guidance Document: Automated Fluorescence in situ...

  19. 21 CFR 866.4700 - Automated fluorescence in situ hybridization (FISH) enumeration systems.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Automated fluorescence in situ hybridization (FISH... Laboratory Equipment and Reagents § 866.4700 Automated fluorescence in situ hybridization (FISH) enumeration... document entitled “Class II Special Controls Guidance Document: Automated Fluorescence in situ...

  20. Overview of the US EPA/SERDP/ESTCP: Laboratory, Field ...

    EPA Pesticide Factsheets

    Passive sampling can be used for applications at contaminated sediment sites including performing assessments of contaminant bioavailability (i.e., freely dissolved concentration (Cfree)), conducting remedial investigations and feasibility studies, and assessing the potential for contaminant bioaccumulation. Previous research articles and documents have discussed many aspects of passive sampling however no definitive guidance on the laboratory, field and analytical procedures for using passive sampling at contaminated sediment sites has been provided. The document discussed in this presentation provides passive sampler users with the guidance necessary to apply the technology to evaluate contaminated sediments. Contaminants discussed include polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and the metals, cadmium, copper, nickel, lead and zinc. The document is divided into sections including discussions of different types of samplers used commonly in the United States, the selection and use of performance reference compounds (PRCs), the extraction and instrumental analysis of passive samplers, data analysis and quality assurance/quality control, and a list of passive sampling related references. The document is not intended to serve as a series of standard operating procedures (SOPs) but rather seeks to provide users with the information needed to develop their own SOPs. The document also includes the names of selected passive sam

  1. 78 FR 56899 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... Request; Requests for Clinical Laboratory Improvement Amendments Categorization AGENCY: Food and Drug... Laboratory Improvement Amendments of 1988 (CLIA) Categorization--42 CFR 493.17 (OMB Control Number 0910-0607)--Extension. A guidance document entitled ``Guidance for Administrative Procedures for CLIA Categorization...

  2. Single Laboratory Validated Method for Determination of Cylindrospermopsin and Anatoxin-a in Ambient Freshwaters by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

    EPA Pesticide Factsheets

    This document is a standardized single laboratory validated liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the detection and quantification of cyanotoxins (combined intracellular and extracellular) in ambient freshwaters.

  3. Earth Control and Investigations: Training Course 1974.

    ERIC Educational Resources Information Center

    Department of the Interior, Denver, CO. Engineering and Research Center.

    This document contains the outlines of each of 34 lectures given in the Earth Control and Investigations course sponsored by the Denver Laboratories. Topics covered include construction control of earth dams, canals, and filters; field and laboratory test procedures; soil classification and logging; and field investigations. (DT)

  4. Laboratory Animal Welfare Supplement IV.

    ERIC Educational Resources Information Center

    Gluckstein, Fritz P., Comp.

    This document is the fourth supplement to a 1984 bibliography on laboratory animal welfare. Items presented were selected because they represent some of the most significant of those providing recent information or because they were considered useful. The period covered is October, 1986 through October, 1987. Monographs, conference proceedings,…

  5. Self Audits of Hazardous Waste Operations in Laboratories.

    ERIC Educational Resources Information Center

    Fischer, Kenneth E.

    1987-01-01

    Discusses the need for compliance with state and federal regulations regarding the handling of hazardous wastes in college chemistry laboratories. Addresses: (1) waste determination; (2) facility requirements; (3) use of the manifest, vendor, transporter, site selection requirements, and training; (4) contingency planning; and (5) documentation.…

  6. Annotated Bibliography of Human Factors Laboratory Reports (1945-1968). Supplement 4, 1979-1983.

    DTIC Science & Technology

    1984-01-01

    A complete bibliographic reference and an abstract are given for each publication of the Human Factors Laboratory from 1979 through 1983 including in-house and contractor - developed documents. Three indexes are provided: Index by Source, Author Index , and Subject Matter Index.

  7. Zero-gravity atmospheric Cloud Physics Experiment Laboratory; Programmatics report

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The programmatics effort included comprehensive analyses in four major areas: (1) work breakdown structure, (2) schedules, (3) costs, and (4) supporting research and technology. These analyses are discussed in detail in the following sections which identify and define the laboratory project development schedule, cost estimates, funding distributions and supporting research and technology requirements. All programmatics analyses are correlated among themselves and with the technical analyses by means of the work breakdown structure which serves as a common framework for program definition. In addition, the programmatic analyses reflect the results of analyses and plans for reliability, safety, test, and maintenance and refurbishment.

  8. Methodological Framework for Analysis of Buildings-Related Programs with BEAMS, 2008

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Elliott, Douglas B.; Dirks, James A.; Hostick, Donna J.

    The U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) develops official “benefits estimates” for each of its major programs using its Planning, Analysis, and Evaluation (PAE) Team. PAE conducts an annual integrated modeling and analysis effort to produce estimates of the energy, environmental, and financial benefits expected from EERE’s budget request. These estimates are part of EERE’s budget request and are also used in the formulation of EERE’s performance measures. Two of EERE’s major programs are the Building Technologies Program (BT) and the Weatherization and Intergovernmental Program (WIP). Pacific Northwest National Laboratory (PNNL) supports PAEmore » by developing the program characterizations and other market information necessary to provide input to the EERE integrated modeling analysis as part of PAE’s Portfolio Decision Support (PDS) effort. Additionally, PNNL also supports BT by providing line-item estimates for the Program’s internal use. PNNL uses three modeling approaches to perform these analyses. This report documents the approach and methodology used to estimate future energy, environmental, and financial benefits using one of those methods: the Building Energy Analysis and Modeling System (BEAMS). BEAMS is a PC-based accounting model that was built in Visual Basic by PNNL specifically for estimating the benefits of buildings-related projects. It allows various types of projects to be characterized including whole-building, envelope, lighting, and equipment projects. This document contains an overview section that describes the estimation process and the models used to estimate energy savings. The body of the document describes the algorithms used within the BEAMS software. This document serves both as stand-alone documentation for BEAMS, and also as a supplemental update of a previous document, Methodological Framework for Analysis of Buildings-Related Programs: The GPRA Metrics Effort, (Elliott et al. 2004b). The areas most changed since the publication of that previous document are those discussing the calculation of lighting and HVAC interactive effects (for both lighting and envelope/whole-building projects). This report does not attempt to convey inputs to BEAMS or the methodology of their derivation.« less

  9. Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo.

    PubMed

    Osadebe, Lynda; Hughes, Christine M; Shongo Lushima, Robert; Kabamba, Joelle; Nguete, Beatrice; Malekani, Jean; Pukuta, Elisabeth; Karhemere, Stomy; Muyembe Tamfum, Jean-Jacques; Wemakoy Okitolonda, Emile; Reynolds, Mary G; McCollum, Andrea M

    2017-09-01

    Human monkeypox (MPX) occurs at appreciable rates in the Democratic Republic of Congo (DRC). Infection with varicella zoster virus (VZV) has a similar presentation to that of MPX, and in areas where MPX is endemic these two illnesses are commonly mistaken. This study evaluated the diagnostic utility of two surveillance case definitions for MPX and specific clinical characteristics associated with laboratory-confirmed MPX cases. Data from a cohort of suspect MPX cases (identified by surveillance over the course of a 42 month period during 2009-2014) from DRC were used; real-time PCR diagnostic test results were used to establish MPX and VZV diagnoses. A total of 333 laboratory-confirmed MPX cases, 383 laboratory-confirmed VZV cases, and 36 cases that were determined to not be either MPX or VZV were included in the analyses. Significant (p<0.05) differences between laboratory-confirmed MPX and VZV cases were noted for several signs/symptoms including key rash characteristics. Both surveillance case definitions had high sensitivity and low specificities for individuals that had suspected MPX virus infections. Using 12 signs/symptoms with high sensitivity and/or specificity values, a receiver operator characteristic analysis showed that models for MPX cases that had the presence of 'fever before rash' plus at least 7 or 8 of the 12 signs/symptoms demonstrated a more balanced performance between sensitivity and specificity. Laboratory-confirmed MPX and VZV cases presented with many of the same signs and symptoms, and the analysis here emphasized the utility of including 12 specific signs/symptoms when investigating MPX cases. In order to document and detect endemic human MPX cases, a surveillance case definition with more specificity is needed for accurate case detection. In the absence of a more specific case definition, continued emphasis on confirmatory laboratory-based diagnostics is warranted.

  10. Drying results of K-Basin fuel element 1990 (Run 1)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marschman, S.C.; Abrefah, J.; Klinger, G.S.

    1998-06-01

    The water-filled K-Basins in the Hanford 100-Area have been used to store N-Reactor spent nuclear fuel (SNF) since the 1970s. Because some leaks in the basins have been detected and some of the fuel is breached due to handling damage and corrosion, efforts are underway to remove the fuel elements from wet storage. An Integrated Process Strategy (IPS) has been developed to package, dry, transport, and store these metallic uranium fuels in an interim storage facility on the Hanford Site (WHC 1995). Information required to support the development of the drying processes, and the required safety analyses, is being obtainedmore » from characterization tests conducted on fuel elements removed from the K-Basins. A series of whole element drying tests (reported in separate documents, see Section 8.0) have been conducted by Pacific Northwest National Laboratory (PNNL) on several intact and damaged fuel elements recovered from both the K-East and K-West Basins. This report documents the results of the first of those tests (Run 1), which was conducted on an N-Reactor inner fuel element (1990) that had been stored underwater in the K-West Basin (see Section 2.0). This fuel element was subjected to a combination of low- and high-temperature vacuum drying treatments that were intended to mimic, wherever possible, the fuel treatment strategies of the IPS. The testing was conducted in the Whole Element Furnace Testing System, described in Section 3.0, located in the Postirradiation Testing Laboratory (PTL, 327 Building). The test conditions and methodology are given in Section 4.0, and the experimental results provided in Section 5.0. These results are further discussed in Section 6.0.« less

  11. Improving Army Basic Research: Report of an Expert Panel on the Future of Army Laboratories

    DTIC Science & Technology

    2012-01-01

    commercial use only. Unauthorized posting of RAND electronic documents to a non-RAND website is prohibited. RAND electronic documents are protected under...complete. Copies may not be duplicated for commercial purposes. Unauthorized posting of RAND documents to a non-RAND website is prohibited. RAND...Inspired senior scientists and technologists with vision will be essential in research as well as in the design , development, evaluation, and

  12. Crew Systems Laboratory/Building 7. Historical Documentation

    NASA Technical Reports Server (NTRS)

    Slovinac, Patricia

    2011-01-01

    Building 7 is managed by the Crew and Thermal Systems Division of the JSC Engineering Directorate. Originally named the Life Systems Laboratory, it contained five major test facilities: two advanced environmental control laboratories and three human-rated vacuum chambers (8 , 11 , and the 20 ). These facilities supported flight crew familiarization and the testing and evaluation of hardware used in the early manned spaceflight programs, including Gemini, Apollo, and the ASTP.

  13. Laboratory Testing of Electro-Osmotic Pulse Technology to Reduce and Maintain Low Moisture Content in Concrete

    DTIC Science & Technology

    2009-02-01

    technology minimizes harmful effects to concrete and rebar and prevents over drying, pore blocking and electrode polarization. Principles of EOP...LABORATORY TESTING OF ELECTRO-OSMOTIC PULSE TECHNOLOGY TO REDUCE AND MAINTAIN LOW MOISTURE CONTENT IN CONCRETE Orange S. Marshall, Vincent F...Laboratory 2009 Army Corrosion Summit Clearwater Beach, FL 6 January 2009 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting

  14. XML syntax for clinical laboratory procedure manuals.

    PubMed

    Saadawi, Gilan; Harrison, James H

    2003-01-01

    We have developed a document type description (DTD) in Extensable Markup Language (XML) for clinical laboratory procedures. Our XML syntax can adequately structure a variety of procedure types across different laboratories and is compatible with current procedure standards. The combination of this format with an XML content management system and appropriate style sheets will allow efficient procedure maintenance, distributed access, customized display and effective searching across a large body of test information.

  15. Investigation into stutter ratio variability between different laboratories.

    PubMed

    Bright, Jo-Anne; Curran, James M

    2014-11-01

    The determination of parameters such as stutter ratio is important to inform a laboratory's forensic DNA profile interpretation strategy. As part of a large data analysis project to implement a continuous model of DNA profile interpretation we analysed stutter ratio data from eight different forensic laboratories for the Promega PowerPlex(®) 21 multiplex. This allowed a comparison of inter laboratory variation. The maximum difference for any one laboratory from the average of the best fit determined by the model was 0.31%. These results indicate that stutter ratios calculated from samples analysed using the same profiling kit are not expected to differ between laboratories, even those using different capillary electrophoresis platforms. A common set of laboratory parameters are able to be generated and used for profile interpretation at all laboratories using the same multiplex and cycle number, potentially reducing the need for individual laboratories to determine stutter ratios. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. Using a Theoretical Framework of Institutional Culture to Analyse an Institutional Strategy Document

    ERIC Educational Resources Information Center

    Jacobs, Anthea Hydi Maxine

    2016-01-01

    This paper builds on a conceptual analysis of institutional culture in higher education. A theoretical framework was proposed to analyse institutional documents of two higher education institutions in the Western Cape, for the period 2002 to 2012 (Jacobs 2012). The elements of this theoretical framework are "shared values and beliefs",…

  17. Radiological Laboratory Sample Analysis Guide for Incidents of National Significance – Radionuclides in Air

    EPA Science Inventory

    [The document describes the likely analytical decision paths that would be made by personnel at a radioanalytical laboratory following a radiological or nuclear incident, such as that caused by a terrorist attack. EPA’s responsibilities, as outlined in the National Response Frame...

  18. Regional Educational Laboratory Researcher-Practitioner Partnerships: Documenting the Research Alliance Experience. REL 2018-291

    ERIC Educational Resources Information Center

    Scher, Lauren; McCowan, Ronald; Castaldo-Walsh, Cynthia

    2018-01-01

    This report provides a detailed account of the Regional Educational Laboratory (REL) Program's experience establishing and supporting research-practice partnerships (called "research alliances") during its 2012-17 contract cycle. The report adds to the growing literature base on researcher-practitioner partnerships by sharing how the…

  19. Laboratory Safety Manual for Alabama Schools. Bulletin 1975. No. 20.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery.

    This document presents the Alabama State Department of Education guidelines for science laboratory safety, equipment, storage, chemical safety, rocket safety, electrical safety, safety with radioisotopes, and safety with biologicals. Also included is a brief bibliography, a teacher's checklist, a listing of laser facts and regulations, and a…

  20. Single Laboratory Validated Method for Determination of Microcystins and Nodularin in Ambient Freshwaters by Solid Phase Extraction and Liquid Chromatography/ Tandem Mass Spectrometry (LC/MS/MS)

    EPA Pesticide Factsheets

    This document is a standardized, single laboratory validated liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the detection of cyanotoxins—microsystins and nodularin (combined intracellular and extracellular)—in ambient freshwaters.

  1. Glossary of software engineering laboratory terms

    NASA Technical Reports Server (NTRS)

    1982-01-01

    A glossary of terms used in the Software Engineering Laboratory (SEL) is presented. The terms are defined within the context of the software development environment for flight dynamics at Goddard Space Flight Center. A concise reference for clarifying and understanding the language employed in SEL documents and data collection forms is provided.

  2. SUPERFUND TREATABILITY CLEARINGHOUSE: LABORATORY FEASIBILITY TESTING OF PROTOTYPE SOIL WASHING CONCEPTS

    EPA Science Inventory

    This draft document reports on laboratory testing of several washing solutions to decontaminate soils contaminated vith dioxins. The following extractants were evaluated; surfactant mixtures of 0.5% to 3% Adsee 799 and 0.5* to 3% Hyonic NP90 in distilled water, Freon TF with ...

  3. Learning to Think in a Math Lab.

    ERIC Educational Resources Information Center

    Charbonneau, Manon P.

    This document begins with a discussion of the author's approach to instruction in a mathematics laboratory. This discussion includes an enumeration of types of desirable or necessary equipment and advice on the management of a laboratory. The author examines issues related to achievement and readiness for more traditional school experiences in…

  4. Cleanup Verification Package for the 100-F-20, Pacific Northwest Laboratory Parallel Pits

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    M. J. Appel

    2007-01-22

    This cleanup verification package documents completion of remedial action for the 100-F-20, Pacific Northwest Laboratory Parallel Pits waste site. This waste site consisted of two earthen trenches thought to have received both radioactive and nonradioactive material related to the 100-F Experimental Animal Farm.

  5. Investigating Evolutionary Biology in the Laboratory.

    ERIC Educational Resources Information Center

    McComas, William F., Ed.

    This document presents a collection of useful laboratory-based activities for teaching about evolution. Some of the activities in this monograph are previously unpublished exercises, some are new versions of well-known labs, a few make useful classroom demonstrations, and several require somewhat sophisticated equipment. As a group, the activities…

  6. Enhanced Learning of Biotechnology Students by an Inquiry-Based Cellulase Laboratory

    ERIC Educational Resources Information Center

    Ketpichainarong, Watcharee; Panijpan, Bhinyo; Ruenwongsa, Pintip

    2010-01-01

    This study explored the effectiveness of an inquiry-based cellulase laboratory unit in promoting inquiry in undergraduate students in biotechnology. The following tools were used to assess the students' achievements and attitude: conceptual understanding test, concept mapping, students' documents, CLES questionnaire, students' self reflection, and…

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sailer, S.J.

    This Quality Assurance Project Plan (QAPJP) specifies the quality of data necessary and the characterization techniques employed at the Idaho National Engineering Laboratory (INEL) to meet the objectives of the Department of Energy (DOE) Waste Isolation Pilot Plant (WIPP) Transuranic Waste Characterization Quality Assurance Program Plan (QAPP) requirements. This QAPJP is written to conform with the requirements and guidelines specified in the QAPP and the associated documents referenced in the QAPP. This QAPJP is one of a set of five interrelated QAPjPs that describe the INEL Transuranic Waste Characterization Program (TWCP). Each of the five facilities participating in the TWCPmore » has a QAPJP that describes the activities applicable to that particular facility. This QAPJP describes the roles and responsibilities of the Idaho Chemical Processing Plant (ICPP) Analytical Chemistry Laboratory (ACL) in the TWCP. Data quality objectives and quality assurance objectives are explained. Sample analysis procedures and associated quality assurance measures are also addressed; these include: sample chain of custody; data validation; usability and reporting; documentation and records; audits and 0385 assessments; laboratory QC samples; and instrument testing, inspection, maintenance and calibration. Finally, administrative quality control measures, such as document control, control of nonconformances, variances and QA status reporting are described.« less

  8. Pacific Northwest Laboratory Institutional Plan FY 1995-2000

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-12-01

    This report serves as a document to describe the role PNL is positioned to take in the Department of Energy`s plans for its national centers in the period 1995-2000. It highlights the strengths of the facilities and personnel present at the laboratory, touches on the accomplishments and projects they have contributed to, and the direction being taken to prepare for the demands to be placed on DOE facilities in the near and far term. It consists of sections titled: director`s statement; laboratory mission and core competencies; laboratory strategic plan; laboratory initiatives; core business areas; critical success factors.

  9. Inter-laboratory comparison of X-ray fluorescence analyses of eruptive products of El Chichón Volcano, Chiapas, Mexico

    USGS Publications Warehouse

    Tilling, Robert I.; Bornhorst, Theodore J.; Taggart, Joseph E.; Rose, William I.; McGee, James J.

    1987-01-01

    An inter-laboratory comparison has been made of X-ray fluorescence analyses of 10 samples of lava and pumices from El Chichón Volcano, Chiapas, Mexico. Some determinations of major-element constituents agree within analytical uncertainty, whereas others exchibit significant bias. Analyses carried out at the Michigan Technological University (MTU) laboratory are systematically lower in MgO (26–48%), Fetotal(5–18%), CaO (4–15%) and higher in K2O (0–15%) than analyses made at the U.S. Geological Survey (USGS) Denver laboratory. These differences are ascribed in part to a complex combination of calibration assumptionsand mineralogical and particle-size effects inherent in the use of pressed rock-powder pellets in the analytical procedure of the MTU laboratory. Other, but as yet unknown, differences in sample preparation and/or analytical technique may also be important; effects related to natural sample inhomogeneityare believed to be insignificant. The inter-laboratory differences in the analytical data complicated accurate assessment of whether El Chichón magmas have changed composition during the past 300 000 a. Knowledge of such change is needed for understanding petrogenetic history and for such related studies as evaluation of volcanic hazards.

  10. Feasibility of hospital-initiated non-facilitator assisted advance care planning documentation for patients with palliative care needs.

    PubMed

    Kok, Maaike; van der Werff, Gertruud F M; Geerling, Jenske I; Ruivenkamp, Jaap; Groothoff, Wies; van der Velden, Annette W G; Thoma, Monique; Talsma, Jaap; Costongs, Louk G P; Gans, Reinold O B; de Graeff, Pauline; Reyners, Anna K L

    2018-05-24

    Advance Care Planning (ACP) and its documentation, accessible to healthcare professionals regardless of where patients are staying, can improve palliative care. ACP is usually performed by trained facilitators. However, ACP conversations would be more tailored to a patient's specific situation if held by a patient's clinical healthcare team. This study assesses the feasibility of ACP by a patient's clinical healthcare team, and analyses the documented information including current and future problems within the palliative care domains. This multicentre study was conducted at the three Groningen Palliative Care Network hospitals in the Netherlands. Patients discharged from hospital with a terminal care indication received an ACP document from clinical staff (non-palliative care trained staff at hospitals I and II; specialist palliative care nurses at hospital III) after they had held ACP conversations. An anonymised copy of this ACP document was analysed. Documentation rates of patient and contact details were investigated, and documentation of current and future problems were analysed both quantitatively and qualitatively. One hundred sixty ACP documents were received between April 2013 and December 2014, with numbers increasing for each consecutive 3-month time period. Advance directives were frequently documented (82%). Documentation rates of current problems in the social (24%), psychological (27%) and spiritual (16%) domains were low compared to physical problems (85%) at hospital I and II, but consistently high (> 85%) at hospital III. Of 545 documented anticipated problems, 92% were physical or care related in nature, 2% social, 5% psychological, and < 1% spiritual. Half of the anticipated non-physical problems originated from hospital III. Hospital-initiated ACP documentation by a patient's clinical healthcare team is feasible: the number of documents received per time period increased throughout the study period, and overall, documentation rates were high. Nonetheless, symptom documentation predominantly regards physical symptoms. With the involvement of specialist palliative care nurses, psychological and spiritual problems are addressed more frequently. Whether palliative care education for non-palliative care experts will improve identification and documentation of non-physical problems remains to be investigated.

  11. The quality of laboratory aspects of troponin testing in clinical practice guidelines and consensus documents needs to be improved.

    PubMed

    Aakre, Kristin M; Langlois, Michel R; Barth, Julian H; Misra, Shivani; Watine, Joseph; Oosterhuis, Wytze P

    2014-11-01

    The European Federation of Laboratory Medicine (EFLM) and the Union of European Medical Specialists (UEMS) joint Working Group on guidelines recently proposed a checklist to help standardize the description of laboratory investigations in clinical practice guidelines (CPG). Nine CPGs or consensus documents published from 2011 to 2013 describing the investigation of chest pain, diagnosis of acute coronary syndrome, or myocardial infarction were evaluated against the published checklist. Clinical use of troponin analysis are commonly dealt with but the publications present variable, vague and sometimes conflicting information regarding this laboratory test being very much relied on upon making a diagnosis of acute coronary syndrome. Most of the laboratory related checklist items are not considered or need to be updated e.g. suggested analytical quality goals are not applicable for the high sensitive assays and important interferences that may lead to false positive or negative diagnoses are commonly not mentioned. The current paper sums up important analytical and biological issues related to troponin assays and gives suggestions for analytical quality goals that could be included in CPG's. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. International Society for the Advancement of Cytometry cell sorter biosafety standards.

    PubMed

    Holmes, Kevin L; Fontes, Benjamin; Hogarth, Philip; Konz, Richard; Monard, Simon; Pletcher, Charles H; Wadley, Robert B; Schmid, Ingrid; Perfetto, Stephen P

    2014-05-01

    Flow cytometric cell sorting of biological specimens has become prevalent in basic and clinical research laboratories. These specimens may contain known or unknown infectious agents, necessitating precautions to protect instrument operators and the environment from biohazards arising from the use of sorters. To this end the International Society of Analytical Cytology (ISAC) was proactive in establishing biosafety guidelines in 1997 (Schmid et al., Cytometry 1997;28:99-117) and subsequently published revised biosafety standards for cell sorting of unfixed samples in 2007 (Schmid et al., Cytometry Part A J Int Soc Anal Cytol 2007;71A:414-437). Since their publication, these documents have become recognized worldwide as the standard of practice and safety precautions for laboratories performing cell sorting experiments. However, the field of cytometry has progressed since 2007, and the document requires an update. The new Standards provides guidance: (1) for laboratory design for cell sorter laboratories; (2) for the creation of laboratory or instrument specific Standard Operating Procedures (SOP); and (3) on procedures for the safe operation of cell sorters, including personal protective equipment (PPE) and validation of aerosol containment. Published © 2014 Wiley Periodicals Inc.

  13. 7 CFR 93.3 - Analyses available and location of laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Analyses available and location of laboratory. 93.3 Section 93.3 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY...

  14. 27 CFR 22.107 - Pathological laboratories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Pathological laboratories... Pathological laboratories. (a) Pathological laboratories, not operated by a hospital or sanitarium, may... sanitariums. If a pathological laboratory does not exclusively conduct analyses or tests for hospitals or...

  15. 27 CFR 22.107 - Pathological laboratories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Pathological laboratories... Pathological laboratories. (a) Pathological laboratories, not operated by a hospital or sanitarium, may... sanitariums. If a pathological laboratory does not exclusively conduct analyses or tests for hospitals or...

  16. Provision of Pre-Primary Education as a Basic Right in Tanzania: Reflections from Policy Documents

    ERIC Educational Resources Information Center

    Mtahabwa, Lyabwene

    2010-01-01

    This study sought to assess provision of pre-primary education in Tanzania as a basic right through analyses of relevant policy documents. Documents which were published over the past decade were considered, including educational policies, action plans, national papers, the "Basic Education Statistics in Tanzania" documents, strategy…

  17. Sandia National Laboratories Hazardous Waste (RCRA) Information Repository

    Science.gov Websites

    Albuquerque New Mexico. Hard copies of the documents are available for review at Zimmerman Library, located prefer to receive hard copy notices of updates, please download subscription form and mail this completed Select the 'print' button to get a hard copy of your document listings. Instructions for Zimmerman

  18. Solar Cell Calibration and Measurement Techniques

    NASA Technical Reports Server (NTRS)

    Bailey, Sheila; Brinker, Dave; Curtis, Henry; Jenkins, Phillip; Scheiman, Dave

    1997-01-01

    The increasing complexity of space solar cells and the increasing international markets for both cells and arrays has resulted in workshops jointly sponsored by NASDA, ESA and NASA. These workshops are designed to obtain international agreement on standardized values for the AMO spectrum and constant, recommend laboratory measurement practices and establish a set of protocols for international comparison of laboratory measurements. A working draft of an ISO standard, WDI 5387, 'Requirements for Measurement and Calibration Procedures for Space Solar Cells' was discussed with a focus on the scope of the document, a definition of primary standard cell, and required error analysis for all measurement techniques. Working groups addressed the issues of Air Mass Zero (AMO) solar constant and spectrum, laboratory measurement techniques, and the international round robin methodology. A summary is presented of the current state of each area and the formulation of the ISO document.

  19. Solar Cell Calibration and Measurement Techniques

    NASA Technical Reports Server (NTRS)

    Bailey, Sheila; Brinker, Dave; Curtis, Henry; Jenkins, Phillip; Scheiman, Dave

    2004-01-01

    The increasing complexity of space solar cells and the increasing international markets for both cells and arrays has resulted in workshops jointly sponsored by NASDA, ESA and NASA. These workshops are designed to obtain international agreement on standardized values for the AMO spectrum and constant, recommend laboratory measurement practices and establish a set of protocols for international comparison of laboratory measurements. A working draft of an ISO standard, WD15387, "Requirements for Measurement and Calibration Procedures for Space Solar Cells" was discussed with a focus on the scope of the document, a definition of primary standard cell, and required error analysis for all measurement techniques. Working groups addressed the issues of Air Mass Zero (AMO) solar constant and spectrum, laboratory measurement techniques, and te international round robin methodology. A summary is presented of the current state of each area and the formulation of the ISO document.

  20. Online database for documenting clinical pathology resident education.

    PubMed

    Hoofnagle, Andrew N; Chou, David; Astion, Michael L

    2007-01-01

    Training of clinical pathologists is evolving and must now address the 6 core competencies described by the Accreditation Council for Graduate Medical Education (ACGME), which include patient care. A substantial portion of the patient care performed by the clinical pathology resident takes place while the resident is on call for the laboratory, a practice that provides the resident with clinical experience and assists the laboratory in providing quality service to clinicians in the hospital and surrounding community. Documenting the educational value of these on-call experiences and providing evidence of competence is difficult for residency directors. An online database of these calls, entered by residents and reviewed by faculty, would provide a mechanism for documenting and improving the education of clinical pathology residents. With Microsoft Access we developed an online database that uses active server pages and secure sockets layer encryption to document calls to the clinical pathology resident. Using the data collected, we evaluated the efficacy of 3 interventions aimed at improving resident education. The database facilitated the documentation of more than 4 700 calls in the first 21 months it was online, provided archived resident-generated data to assist in serving clients, and demonstrated that 2 interventions aimed at improving resident education were successful. We have developed a secure online database, accessible from any computer with Internet access, that can be used to easily document clinical pathology resident education and competency.

  1. Documentation of Education for Teenagers in Residential Care: A Network of Blame and Critique

    ERIC Educational Resources Information Center

    Severinsson, Susanne

    2017-01-01

    This article presents analyses of documents from special schools in Sweden for students in the care of social welfare who have been assessed with social, emotional and behavioural difficulties. The aim is to use actor-network theory to analyse how blame and critique are handled in individual educational plans, and how responsibilities are produced…

  2. Security Policy for a Generic Space Exploration Communication Network Architecture

    NASA Technical Reports Server (NTRS)

    Ivancic, William D.; Sheehe, Charles J.; Vaden, Karl R.

    2016-01-01

    This document is one of three. It describes various security mechanisms and a security policy profile for a generic space-based communication architecture. Two other documents accompany this document- an Operations Concept (OpsCon) and a communication architecture document. The OpsCon should be read first followed by the security policy profile described by this document and then the architecture document. The overall goal is to design a generic space exploration communication network architecture that is affordable, deployable, maintainable, securable, evolvable, reliable, and adaptable. The architecture should also require limited reconfiguration throughout system development and deployment. System deployment includes subsystem development in a factory setting, system integration in a laboratory setting, launch preparation, launch, and deployment and operation in space.

  3. 40 CFR 240.211-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... measurements and laboratory analyses required by the responsible agency. (12) Complete records of monitoring... waste received and processed, summarized on a monthly basis. (2) A summary of the laboratory analyses including at least monthly averages. (3) Number and qualifications of personnel in each job category; total...

  4. PATRAM '92: 10th international symposium on the packaging and transportation of radioactive materials [Papers presented by Sandia National Laboratories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This document provides the papers presented by Sandia Laboratories at PATRAM '92, the tenth International symposium on the Packaging and Transportation of Radioactive Materials held September 13--18, 1992 in Yokohama City, Japan. Individual papers have been cataloged separately. (FL)

  5. 76 FR 22030 - Third Party Testing for Certain Children's Products; Toddler Beds: Requirements for Accreditation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Laboratory Accreditation Cooperation--Mutual Recognition Arrangement (ILAC-MRA), and the scope of the... and content of the ILAC-MRA approach and of the requirements of the ISO/IEC 17025:2005 laboratory... this document, it must be accredited by an ILAC-MRA signatory accrediting body, and the accreditation...

  6. Directory of AFRL/HEA Technical Publications Submitted to DTIC from 1969 to 2007

    DTIC Science & Technology

    2007-09-01

    Research Division ( AFRL /HEA) 2004 to 30 September 1007 – Air Force Research Laboratory , Warfighter Readiness Research Division ( AFRL /HEA...NUMBER 2003 AIR FORCE RESEARCH LABORATORY WARFIGHTER TRAINING RESEARCH DIVISION ( AFRL /HEA) TECHNICAL DOCUMENTS AUTHOR(S) AFRL -HE-AZ-TP-2003...NUMBER WORK UNIT NUMBER 2002 AIR FORCE RESEARCH

  7. 94-1 Research and development project lead laboratory support. Status report, January 1--March 31, 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dinehart, M.

    1996-09-01

    This document reports status and technical progress for Los Alamos National Laboratories 94-1 Research and Development projects. An introduction to the project structure and an executive summary are included. Projects described include Electrolytic Decontamination, Combustibles, Detox, Sand, Slag, and Crucible, Surveillance, and Core Technology.

  8. Efficient Model Posing and Morphing Software

    DTIC Science & Technology

    2014-04-01

    disclosure of contents or reconstruction of this document. Air Force Research Laboratory 711th Human Performance Wing Human ...Command, Air Force Research Laboratory 711th Human Performance Wing, Human Effectiveness Directorate, Bioeffects Division, Radio Frequency...13. SUPPLEMENTARY NOTES 14. ABSTRACT The absorption of electromagnetic energy within human tissue depends upon anatomical posture and body

  9. METHOD-SPECIFIC PRECISION AND BIAS RELATIONSHIPS DEVELOPED FROM DATA SUBMITTED DURING USEPA DRINKING WATER LABORATORY PERFORMANCE EVALUATION STUDIES

    EPA Science Inventory

    This paper documents the process used by the United States Environmental Protection Agency (USEPA) to estimate the mean and standard deviation of data reported by in-control drinking water laboratories during Water Supply (WS) studies. This process is then applied to the data re...

  10. METHOD-SPECIFIC PRECISION AND BIAS RELATIONSHIPS DEVELOPED FROM DATA SUBMITTED DURING USEPA WASTEWATER LABORATORY PERFORMANCE EVALUATION STUDIES

    EPA Science Inventory

    This paper documents the process used by the United States Environmental Protection Agency (USEPA) to estimate the mean and standard deviation of data reported by in-control wastewater laboratories during Water Pollution (WP) studies. This process is then applied to the data rep...

  11. 21 CFR 58.190 - Storage and retrieval of records and data.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Storage and retrieval of records and data. 58.190...) There shall be archives for orderly storage and expedient retrieval of all raw data, documentation... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.190 Storage...

  12. 21 CFR 58.190 - Storage and retrieval of records and data.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Storage and retrieval of records and data. 58.190...) There shall be archives for orderly storage and expedient retrieval of all raw data, documentation... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.190 Storage...

  13. 21 CFR 58.190 - Storage and retrieval of records and data.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Storage and retrieval of records and data. 58.190...) There shall be archives for orderly storage and expedient retrieval of all raw data, documentation... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.190 Storage...

  14. 21 CFR 58.190 - Storage and retrieval of records and data.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Storage and retrieval of records and data. 58.190...) There shall be archives for orderly storage and expedient retrieval of all raw data, documentation... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.190 Storage...

  15. 21 CFR 58.190 - Storage and retrieval of records and data.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Storage and retrieval of records and data. 58.190...) There shall be archives for orderly storage and expedient retrieval of all raw data, documentation... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.190 Storage...

  16. LABORATORY AND FIELD STUDIES TO EVALUATE RISKS TO LARVAL FISH FROM PHOTO-ACTIVATED TOXICITY OF PAHS

    EPA Science Inventory

    Hazard from photo-activation of PAHs has been well documented in aquatic organisms. Far less certain is the degree to which risk actually occurs in the field. This presentation outlines a series of laboratory and field experiments conducted to better understand the dosimetry and ...

  17. Increasing Student Attendance: Strategies From Research and Practice

    ERIC Educational Resources Information Center

    Railsback, Jennifer

    2004-01-01

    This booklet is one in a series of "hot topics" reports produced by the Northwest Regional Educational Laboratory. These reports briefly address current educational concerns and issues as indicated by requests for information that come to the Laboratory from the Northwest region and beyond. This document focuses on student attendance. During a…

  18. Engineering study for closure of 209E facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brevick, C.H.; Heys, W.H.; Johnson, E.D.

    1997-07-07

    This document is an engineering study for evaluating alternatives to determine the most cost effective closure plan for the 209E Facility, Critical Mass Laboratory. This laboratory is located in the 200 East Area of the Hanford Site and contains a Critical Assembly Room and a Mix room were criticality experiments were once performed.

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    ENVIRONMENT AND WASTE MANAGMENT SERVICES DIVISION; ET AL.

    Each year, Brookhaven National Laboratory (BNL), a multi-program national laboratory, prepares an annual Site Environmental Report (SER) in accordance with Order 231.1A, Environment, Safety and Health Reporting, of the U.S. Department of Energy (DOE). The SER is written to inform outside regulators, the public, and Laboratory employees of BNL's environmental performance during the calendar year in review, and to summarize BNL's on-site environmental data; environmental management performance; compliance with applicable DOE, Environmental Protection Agency (EPA), state, and local regulations; and environmental, restoration, and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of itsmore » environmental history since the Laboratory's inception in 1947. This report is intended to be a technical document. It is available in print and as a downloadable file on the BNL web page at http://www.bnl.ser.htm. A summary of the SER is also prepared each year to provide a general overview, and is distributed with a CD version of the full-length SER. The summary supports BNL's educational and community outreach program.« less

  20. Statistics of natural movements are reflected in motor errors.

    PubMed

    Howard, Ian S; Ingram, James N; Körding, Konrad P; Wolpert, Daniel M

    2009-09-01

    Humans use their arms to engage in a wide variety of motor tasks during everyday life. However, little is known about the statistics of these natural arm movements. Studies of the sensory system have shown that the statistics of sensory inputs are key to determining sensory processing. We hypothesized that the statistics of natural everyday movements may, in a similar way, influence motor performance as measured in laboratory-based tasks. We developed a portable motion-tracking system that could be worn by subjects as they went about their daily routine outside of a laboratory setting. We found that the well-documented symmetry bias is reflected in the relative incidence of movements made during everyday tasks. Specifically, symmetric and antisymmetric movements are predominant at low frequencies, whereas only symmetric movements are predominant at high frequencies. Moreover, the statistics of natural movements, that is, their relative incidence, correlated with subjects' performance on a laboratory-based phase-tracking task. These results provide a link between natural movement statistics and motor performance and confirm that the symmetry bias documented in laboratory studies is a natural feature of human movement.

  1. Orthodontic soldering techniques: aspects of quality assurance in the dental laboratory.

    PubMed

    Heidemann, Jutta; Witt, Emil; Feeg, Martin; Werz, Rainer; Pieger, Klaus

    2002-07-01

    In Germany, the dental technician is required by the Medical Products Act (MPG) to produce workpieces of high safety and quality and to document these properties. Soldering continues to be the prevailing joining technique in the dental laboratory, although problems arise from the susceptibility to corrosion and the low strength of soldered joints. This study aimed to reveal sources of defects in dental laboratory workpieces in order to achieve optimization in terms of quality assurance. The joints were produced by various dental technicians using three different soldering techniques. These joining techniques were investigated for their quality and their corrosion properties during immersion in ferric chloride, orthodontic appliance cleanser, and artificial saliva. Observance of the soldering instructions by the dental technicians was checked. Corrosion attack was confirmed by scanning electron microscopy and by measuring the ion concentrations of copper, silver and zinc in the corrosive agents, using atomic emission spectroscopy with stimulation by inductively coupled plasma (ICP-AES analysis). Incomplete filling of the soldering gap, porosities resulting from the production process, poor corrosion properties, and in particular a high variability of the measured values point to insufficient reliability of two soldering techniques. Variations in quality were also detected among the technicians' modes of operation. The analyses confirm the need for quality assurance of soldering techniques and for increased support for alternative joining techniques such as laser welding in the future. The results of the studies on laser welding are presented in a separate publication.

  2. National NIF Diagnostic Program Fiscal Year 2002 Second Quarter Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MacGowan, B

    Since October 2001 the development of the facility diagnostics for NIF has been funded by the NIF Director through the National NIF Diagnostic Program (NNDP). The current emphasis of the NNDP is on diagnostics for the early NIF quad scheduled to be available for experiment commissioning in FY03. During the past six months the NNDP has set in place processes for funding diagnostics, developing requirements for diagnostics, design reviews and monthly status reporting. Those processes are described in an interim management plan for diagnostics (''National NIF Diagnostic Program Interim Plan'', NIF-0081315, April 2002) and a draft Program Execution Plan (''Programmore » Execution Plan for the National NlF Diagnostic Program'', NIF-0072083, October 2001) and documents cited therein. Work has been funded at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Naval Research Laboratory (NRL), Sandia National Laboratories (SNL), Bechtel Nevada at Los Alamos and Santa Barbara. There are no major technical risks with the early diagnostics. The main concerns relate to integration of the diagnostics into the facility, all such issues are being worked. This report is organized to show the schedule and budget status and a summary of Change Control Board actions for the past six months. The following sections then provide short descriptions of the status of each diagnostic. Where design reviews or requirements documents are cited, the documents are available on the Diagnostics file server or on request.« less

  3. Upward Flame Propagation and Wire Insulation Flammability: 2006 Round Robin Data Analysis

    NASA Technical Reports Server (NTRS)

    Hirsch, David B.

    2007-01-01

    This viewgraph document reviews test results from tests of different material used for wire insulation for flame propagation and flammability. The presentation focused on investigating data variability both within and between laboratories; evaluated the between-laboratory consistency through consistency statistic h, which indicates how one laboratory s cell average compares with averages from other labs; evaluated the within-laboratory consistency through the consistency statistic k, which is an indicator of how one laboratory s within-laboratory variability compares with the variability of other labs combined; and extreme results were tested to determine whether they resulted by chance or from nonrandom causes (human error, instrument calibration shift, non-adherence to procedures, etc.)

  4. Guiding Documents for Environmental Education Centres: An Analysis in the Spanish Context

    ERIC Educational Resources Information Center

    Medir, Rosa Maria; Heras, Raquel; Geli, Anna Maria

    2014-01-01

    Guiding documents under the "PEC" acronym are commonly used in environmental education centres (EECs) in Spain. They are written documents that are seen as necessary tools to safeguard quality. In this study, we analyse the guiding documents of twenty-three EECs in the province of Girona (Catalonia, Spain) in order to understand their…

  5. Laboratory Directed Research and Development annual report, fiscal year 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-03-01

    The Department of Energy Order 413.2(a) establishes DOE`s policy and guidelines regarding Laboratory Directed Research and Development (LDRD) at its multiprogram laboratories. As described in 413.2, LDRD is research and development of a creative and innovative nature which is selected by the Laboratory Director or his or her designee, for the purpose of maintaining the scientific and technological vitality of the Laboratory and to respond to scientific and technological opportunities in conformance with the guidelines in this Order. DOE Order 413.2 requires that each laboratory submit an annual report on its LDRD activities to the cognizant Secretarial Officer through themore » appropriate Operations Office Manager. The report provided in this document represents Pacific Northwest National Laboratory`s LDRD report for FY 1997.« less

  6. Revised guidelines for good practice in IVF laboratories (2015).

    PubMed

    De los Santos, Maria José; Apter, Susanna; Coticchio, Giovanni; Debrock, Sophie; Lundin, Kersti; Plancha, Carlos E; Prados, Fernando; Rienzi, Laura; Verheyen, Greta; Woodward, Bryan; Vermeulen, Nathalie

    2016-04-01

    Which recommendations can be provided by the European Society of Human Reproduction and Embryology Special Interest Group (ESHRE SIG) Embryology to support laboratory specialists in the organization and management of IVF laboratories and the optimization of IVF patient care? Structured in 13 sections, the guideline development group formulated recommendations for good practice in the organization and management of IVF laboratories, and for good practice of the specific procedures performed within the IVF laboratory. NA. The guideline was produced by a group of 10 embryologists representing different European countries, settings and levels of expertise. The group evaluated the document of 2008, and based on this assessment, each group member rewrote one or more sections. Two 2-day meetings were organized during which each of the recommendations was discussed and rewritten until consensus within the guideline group was reached. After finalizing the draft, the members of the ESHRE SIG embryology were invited to review the guideline. NA. The guideline provides recommendations on the general organization of an IVF laboratory (staffing and direction, quality management, laboratory safety), and on the specific aspects of the procedures performed in IVF laboratories (Identification of patients and traceability of their reproductive cells, consumables, handling of biological material, oocyte retrieval, sperm preparation, insemination of oocytes, scoring for fertilization, embryo culture and transfer, and cryopreservation). A last section provides recommendations regarding an Emergency plan for IVF laboratories. Evidence on most of the issues described is scarce, and therefore it was decided not to perform a formal search for and assessment of scientific evidence. However, recommendations published in the EUTCD and relevant and recent documents, manuals and consensus papers were taken into account when formulating the recommendations. Despite the limitations, the guideline group is confident that this document will be helpful to directors and managers involved in the management and organization of IVF laboratories, but also to embryologists and laboratory technicians performing daily tasks. The guideline was developed and funded by ESHRE, covering expenses associated with the guideline meetings. The guideline group members did not receive payment. Dr Coticchio reports speaker's fees from IBSA and Cook, outside the submitted work; Dr Lundin reports grants from Vitrolife, personal fees from Merck Serono, non-financial support from Unisense, outside the submitted work; Dr. Rienzi reports personal fees from Merck Serono, personal fees from MSD, grants from GFI, outside the submitted work; the other authors had nothing to disclose. NA. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kelly, D L

    The US Department of Energy (DOE) has been conducting, through several of its operating contractors, an evaluation and testing program to qualify Type A radioactive material packagings per US Department of Transportation (DOT) Specification 7A (DOT-7A) of the Code of Federal Regulations (CFR), Title 49, Part 178 (49 CFR 178). This document summarizes the evaluation and testing performed for all of the packagings successfully qualified in this program. This document supersedes DOE Evaluation Document for DOT-7A Type A Packaging (Edling 1987), originally issued in 1987 by Monsanto Research Corporation Mound Laboratory (MLM), Miamisburg, Ohio, for the Department of Energy, Securitymore » Evaluation Program (I)P-4. Mound Laboratory issued four revisions to the document between November 1988 and December 1989. In September 1989, the program was transferred to Westinghouse Hanford Company (Westinghouse Hanford) in Richland, Washington. One additional revision was issued in March 1990 by Westinghouse Hanford. This revision reflects the earlier material and incorporates a number of changes. Evaluation and testing activities on 1208 three DOT-7A Program Dockets resulted in the qualification of three new packaging configurations, which are incorporated herein and summarized. This document presents approximately 300 different packagings that have been determined to meet the requirements for a DOT-7A, type A packaging per 49 CFR 178.350.« less

  8. Atmospheric Dispersal and Dispostion of Tephra From a Potential Volcanic Eruption at Yucca Mountain, Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G. Keating; W.Statham

    2004-02-12

    The purpose of this model report is to provide documentation of the conceptual and mathematical model (ASHPLUME) for atmospheric dispersal and subsequent deposition of ash on the land surface from a potential volcanic eruption at Yucca Mountain, Nevada. This report also documents the ash (tephra) redistribution conceptual model. The ASHPLUME conceptual model accounts for incorporation and entrainment of waste fuel particles associated with a hypothetical volcanic eruption through the Yucca Mountain repository and downwind transport of contaminated tephra. The ASHPLUME mathematical model describes the conceptual model in mathematical terms to allow for prediction of radioactive waste/ash deposition on the groundmore » surface given that the hypothetical eruptive event occurs. This model report also describes the conceptual model for tephra redistribution from a basaltic cinder cone. Sensitivity analyses and model validation activities for the ash dispersal and redistribution models are also presented. Analyses documented in this model report will improve and clarify the previous documentation of the ASHPLUME mathematical model and its application to the Total System Performance Assessment (TSPA) for the License Application (TSPA-LA) igneous scenarios. This model report also documents the redistribution model product outputs based on analyses to support the conceptual model.« less

  9. Hawaii Geothermal Project annotated bibliography: Biological resources of the geothermal subzones, the transmission corridors and the Puna District, Island of Hawaii

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, S.E.; Burgett, J.M.

    1993-10-01

    Task 1 of the Hawaii Geothermal Project Interagency Agreement between the Fish and Wildlife Service and the Department of Energy-Oak Ridge National Laboratory (DOE) includes an annotated bibliography of published and unpublished documents that cover biological issues related to the lowland rain forest in Puna, adjacent areas, transmission corridors, and in the proposed Hawaii Geothermal Project (HGP). The 51 documents reviewed in this report cover the main body of biological information for these projects. The full table of contents and bibliography for each document is included along with two copies (as requested in the Interagency Agreement) of the biological sectionsmore » of each document. The documents are reviewed in five main categories: (1) geothermal subzones (29 documents); (2) transmission cable routes (8 documents); (3) commercial satellite launching facility (Spaceport; 1 document); (4) manganese nodule processing facility (2 documents); (5) water resource development (1 document); and (6) ecosystem stability and introduced species (11 documents).« less

  10. B-52G crew noise exposure study

    NASA Astrophysics Data System (ADS)

    Decker, W. H.; Nixon, C. W.

    1985-08-01

    The B-52G aircraft produces acoustic environments that are potentially hazardous, interfere with voice communications and may degrade task performance. Numerous reports from aircrew of high noise levels at crew location have been documented for those B-52G aircraft that have been modified with the Offensive Avionics System. To alleviate and minimize the excessive noise exposures of aircrews, a study of the noise problem in the b-52G was deemed necessary. First, in-flight noise measurements were obtained at key personnel locations on a B-52G during a typical training mission. Then, extensive laboratory analyses were conducted on these in-flight noise data. The resulting noise exposure data were evaluated in terms of the various segments of and the total flight profile relative to allowable noise exposures. Finally, recommendations were developed for short term and long term approaches toward potential improvement in the B-52G noise exposure problem.

  11. Pontiac fever: isolation of the etiologic agent (Legionella pneumophilia) and demonstration of its mode of transmission.

    PubMed

    Kaufmann, A F; McDade, J E; Patton, C M; Bennett, J V; Skaliy, P; Feeley, J C; Anderson, D C; Potter, M E; Newhouse, V F; Gregg, M B; Brachman, P S

    1981-09-01

    Pontiac fever, a unique epidemiologic form of legionellosis, is characterized by a short (one- to two-day) incubation period and a self-limited grippe-like illness without pneumonia. In 1968, the first documented outbreak of this syndrome affected persons who had entered a health department building in Pontiac, Michigan. Epidemiologic analyses clearly implicated as airborne agent and suggested that evaporative condenser water aerosols being disseminated by a defective air conditioning system played a key role in the outbreak. Guinea pigs that were exposed in the building and to laboratory aerosols of evaporative condenser water developed bronchopneumonia. Legionella pneumophilia (serogroup 1) was isolated from the exposed guinea pigs' lungs. Paired acute and convalescent serum specimens from 37 patients were tested by the indirect fluorescent antibody technique using L. pneumophila serogroup 1 antigen, and 31 (84%) had rises in titer from less than 32 to greater than or equal to 64.

  12. Dynamic stability experiment of Maglev systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cai, Y.; Mulcahy, T.M.; Chen, S.S.

    1995-04-01

    This report summarizes the research performed on Maglev vehicle dynamic stability at Argonne National Laboratory during the past few years. It also documents magnetic-force data obtained from both measurements and calculations. Because dynamic instability is not acceptable for any commercial Maglev system, it is important to consider this phenomenon in the development of all Maglev systems. This report presents dynamic stability experiments on Maglev systems and compares their numerical simulation with predictions calculated by a nonlinear dynamic computer code. Instabilities of an electrodynamic system (EDS)-type vehicle model were obtained from both experimental observations and computer simulations for a five-degree-of-freedom Maglevmore » vehicle moving on a guideway consisting of double L-shaped aluminum segments attached to a rotating wheel. The experimental and theoretical analyses developed in this study identify basic stability characteristics and future research needs of Maglev systems.« less

  13. Dynamic stability of repulsive-force maglev suspension systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cai, Y.; Rote, D.M.; Mulcahy, T.M.

    1996-11-01

    This report summarizes the research performed on maglev vehicle dynamic stability at Argonne National Laboratory during the past few years. It also documents both measured and calculated magnetic-force data. Because dynamic instability is not acceptable for any commercial maglev system, it is important to consider this phenomenon in the development of all maglev systems. This report presents dynamic stability experiments on maglev systems and compares the results with predictions calculated by a nonlinear-dynamics computer code. Instabilities of an electrodynamic-suspension system type vehicle model were obtained by experimental observation and computer simulation of a five-degree-of-freedom maglev vehicle moving on a guidewaymore » that consists of a pair of L-shaped aluminum conductors attached to a rotating wheel. The experimental and theoretical analyses developed in this study identify basic stability characteristics and future research needs of maglev systems.« less

  14. Data management of a multilaboratory field program using distributed processing. [PRECP

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tichler, J.L.

    The PRECP program is a multilaboratory research effort conducted by the US Department of Energy as a part of the National Acid Precipitation Assessment Program (NAPAP). The primary objective of PRECP is to provide essential information for the quantitative description of chemical wet deposition as a function of air pollution loadings, geograpic location, and atmospheric processing. The program is broken into four closely interrelated sectors: Diagnostic Modeling; Field Measurements; Laboratory Measurements; and Climatological Evaluation. Data management tasks are: compile databases of the data collected in field studies; verify the contents of data sets; make data available to program participants eithermore » on-line or by means of computer tapes; perform requested analyses, graphical displays, and data aggregations; provide an index of what data is available; and provide documentation for field programs both as part of the computer database and as data reports.« less

  15. Evaluation Framework and Analyses for Thermal Energy Storage Integrated with Packaged Air Conditioning

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kung, F.; Deru, M.; Bonnema, E.

    2013-10-01

    Few third-party guidance documents or tools are available for evaluating thermal energy storage (TES) integrated with packaged air conditioning (AC), as this type of TES is relatively new compared to TES integrated with chillers or hot water systems. To address this gap, researchers at the National Renewable Energy Laboratory conducted a project to improve the ability of potential technology adopters to evaluate TES technologies. Major project outcomes included: development of an evaluation framework to describe key metrics, methodologies, and issues to consider when assessing the performance of TES systems integrated with packaged AC; application of multiple concepts from the evaluationmore » framework to analyze performance data from four demonstration sites; and production of a new simulation capability that enables modeling of TES integrated with packaged AC in EnergyPlus. This report includes the evaluation framework and analysis results from the project.« less

  16. A Summary of Numerous Strain-Gage Load Calibrations on Aircraft Wings and Tails in a Technological Format

    NASA Technical Reports Server (NTRS)

    Jenkins, Jerald M.; DeAngelis, V. Michael

    1997-01-01

    Fifteen aircraft structures that were calibrated for flight loads using strain gages are examined. The primary purpose of this paper is to document important examples of load calibrations on airplanes during the past four decades. The emphasis is placed on studying the physical procedures of calibrating strain-gaged structures and all the supporting analyses and computational techniques that have been used. The results and experiences obtained from actual data from 14 structures (on 13 airplanes and 1 laboratory test structure) are presented. This group of structures includes fins, tails, and wings with a wide variety of aspect ratios. Straight- wing, swept-wing, and delta-wing configurations are studied. Some of the structures have skin-dominant construction; others are spar-dominant. Anisotropic materials, heat shields, corrugated components, nonorthogonal primary structures, and truss-type structures are particular characteristics that are included.

  17. Idaho National Laboratory Cultural Resource Management Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lowrey, Diana Lee

    2009-02-01

    As a federal agency, the U.S. Department of Energy has been directed by Congress, the U.S. president, and the American public to provide leadership in the preservation of prehistoric, historic, and other cultural resources on the lands it administers. This mandate to preserve cultural resources in a spirit of stewardship for the future is outlined in various federal preservation laws, regulations, and guidelines such as the National Historic Preservation Act, the Archaeological Resources Protection Act, and the National Environmental Policy Act. The purpose of this Cultural Resource Management Plan is to describe how the Department of Energy, Idaho Operations Officemore » will meet these responsibilities at the Idaho National Laboratory. This Laboratory, which is located in southeastern Idaho, is home to a wide variety of important cultural resources representing at least 13,500 years of human occupation in the southeastern Idaho area. These resources are nonrenewable; bear valuable physical and intangible legacies; and yield important information about the past, present, and perhaps the future. There are special challenges associated with balancing the preservation of these sites with the management and ongoing operation of an active scientific laboratory. The Department of Energy, Idaho Operations Office is committed to a cultural resource management program that accepts these challenges in a manner reflecting both the spirit and intent of the legislative mandates. This document is designed for multiple uses and is intended to be flexible and responsive to future changes in law or mission. Document flexibility and responsiveness will be assured through annual reviews and as-needed updates. Document content includes summaries of Laboratory cultural resource philosophy and overall Department of Energy policy; brief contextual overviews of Laboratory missions, environment, and cultural history; and an overview of cultural resource management practices. A series of appendices provides important details that support the main text.« less

  18. Toward implementation of a regional quality assurance program in cytopathology: the Hong Kong experience.

    PubMed

    Ng, Wai-Kuen; Chiu, Conrad S C; Cheng, Yue; Chan, Eva T Y; Chiu, Fanny L L; Collins, Robert J

    2006-01-01

    To develop a local quality assurance program in cytopathology based on circulation of patient specimens on glass slides, with limited resources. A working group was set up for design and running of the program. Participation is on a laboratory basis. The scope and frequency of testing are defined. Well-documented cases (including gynecologic, nongynecologic and fine needle aspiration cytology) with commonly encountered diagnoses are collected. Consensus concerning the diagnosis, interpretive menu and scoring system is sought before the actual slide circulations using express mail. After returning their answers to the program organizer, the participating laboratories receive immediate feedback on their scores, with reference answers, explanatory notes, "whole-mount" images of glass slides and cumulative responses of peer laboratories for on-site checking. At the end of each year, an electronic file containing representative photomicrographs of all cases examined is provided to individual laboratories for their permanent records and training purposes. The program was launched in mid-2003. There were 24 and 27 participating laboratories from Hong Kong (and Macau) in 2003 and 2004, respectively. To date, >150 well-documented cytology cases are available in the slide pool and ready for circulation. As the revenue is mainly to cover the expenses of express mail, the program can be carried out at a relatively low cost. In order to have any cytology quality assurance program accepted by local laboratories, it has to be fair and practical. Strict confidentiality needs to be observed throughout the process. This program emphasizes both performance assessment and educational value. Adequate representation from experienced local cytology workers, detailed documentation support from authorities and assistance from dedicated staff are essential to the success of any external proficiency testing scheme. Regular review and evaluation are also necessary for continuous improvement. The Hong Kong experience can serve as an example of running a glass slide-based cytology quality assurance program in a small region with limited resources.

  19. Idaho National Laboratory Cultural Resource Management Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lowrey, Diana Lee

    As a federal agency, the U.S. Department of Energy has been directed by Congress, the U.S. president, and the American public to provide leadership in the preservation of prehistoric, historic, and other cultural resources on the lands it administers. This mandate to preserve cultural resources in a spirit of stewardship for the future is outlined in various federal preservation laws, regulations, and guidelines such as the National Historic Preservation Act, the Archaeological Resources Protection Act, and the National Environmental Policy Act. The purpose of this Cultural Resource Management Plan is to describe how the Department of Energy, Idaho Operations Officemore » will meet these responsibilities at the Idaho National Laboratory. This Laboratory, which is located in southeastern Idaho, is home to a wide variety of important cultural resources representing at least 13,500 years of human occupation in the southeastern Idaho area. These resources are nonrenewable; bear valuable physical and intangible legacies; and yield important information about the past, present, and perhaps the future. There are special challenges associated with balancing the preservation of these sites with the management and ongoing operation of an active scientific laboratory. The Department of Energy, Idaho Operations Office is committed to a cultural resource management program that accepts these challenges in a manner reflecting both the spirit and intent of the legislative mandates. This document is designed for multiple uses and is intended to be flexible and responsive to future changes in law or mission. Document flexibility and responsiveness will be assured through annual reviews and as-needed updates. Document content includes summaries of Laboratory cultural resource philosophy and overall Department of Energy policy; brief contextual overviews of Laboratory missions, environment, and cultural history; and an overview of cultural resource management practices. A series of appendices provides important details that support the main text.« less

  20. SOIL AND FILL LABORATORY SUPPORT - 1992 RADIOLOGICAL ANALYSES - FLORIDA RADON RESEARCH PROGRAM

    EPA Science Inventory

    The report gives results of soil analysis laboratory work by the University of Florida in support of the Florida Radon Research Program (FRRP). Analyses were performed on soil and fill samples collected during 1992 by the FRRP Research House Program and the New House Evaluation P...

  1. Communication and the laboratory physician

    PubMed Central

    Penistan, J. L.

    1973-01-01

    A clinical laboratory documentation system is described, suitable for community hospitals without computer services. The system is cumulative and is designed to provide the laboratory physician with the clinical information necessary for intelligent review and comment on the laboratory's findings. The mode of presentation of requests to the laboratory and lay-out of the reports to the clinicians are designed to make the two-way communication as close and personal as possible; to encourage the selection of those investigations likely to prove rewarding, and to discourage unnecessary investigation. The possibility of important data escaping notice is minimized. The system is economical in capital equipment, labour and supplies. PMID:4758594

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barr, G.E.; Borns, D.J.; Fridrich, C.

    A comprehensive collection of scenarios is presented that connect initiating tectonic events with radionuclide releases by logical and physically possible combinations or sequences of features, events and processes. The initiating tectonic events include both discrete faulting and distributed rock deformation developed through the repository and adjacent to it, as well as earthquake-induced ground motion and changes in tectonic stress at the site. The effects of these tectonic events include impacts on the engineered-barrier system, such as container rupture and failure of repository tunnels. These effects also include a wide range of hydrologic effects such as changes in pathways and flowmore » rates in the unsaturated and saturated zones, changes in the water-table configuration, and in the development of perched-water systems. These scenarios are intended go guide performance-assessment analyses and to assist principal investigators in how essential field, laboratory, and calculational studies are used. This suite of scenarios will help ensure that all important aspects of the system disturbance related to a tectonic scenario are captured in numerical analyses. It also provides a record of all options considered by project analysts to provide documentation required for licensing agreement. The final portion of this report discusses issues remaining to be addressed with respect to tectonic activity. 105 refs.« less

  3. Mineral composition of commonly consumed ethnic foods in Europe

    PubMed Central

    Khokhar, Santosh; Garduño-Diaz, Sara D.; Marletta, Luisa; Shahar, Danit R.; Ireland, Jane D.; Jansen-van der Vliet, Martine; de Henauw, Stefaan

    2012-01-01

    Background Ethnic foods are an integral part of food consumption in Europe contributing towards the overall nutrient intake of the population. Food composition data on these foods are crucial for assessing nutrient intake, providing dietary advice and preventing diseases. Objective To analyse selected minerals in authentic and modified ethnic foods commonly consumed in seven EU member states and Israel. Design A list of ethnic foods commonly consumed in selected European countries was generated, primary samples collected and composite sample prepared for each food, which were analysed for dietary minerals at accredited laboratories. Methods for sampling, analysis, data scrutiny and documentation were based on harmonised procedures. Results New data on 128 ethnic foods were generated for inclusion in the national databases of seven EU countries and Israel within the European Food Information Resource (EuroFIR), an EU Network of Excellence. The Na, K, Ca, P, Mg, Mn, Cl, Fe, Cu, Zn, Se and I contents of 39 foods is presented for the first time in this study. Conclusion The data will serve as an important tool in future national and international food consumption surveys, to target provision of dietary advice, facilitate implementation of policies and inform policymakers, health workers, food industry and researchers. PMID:22768018

  4. Oyster Reef Communities in the Chesapeake Bay: A Brief Primer. VORTEX: Virginia's Oyster Reef Teaching EXperience.

    ERIC Educational Resources Information Center

    Harding, Juliana M.; Mann, Roger; Clark, Vicki P.

    This document introduces Virginia's Oyster Reef Teaching EXperience (VORTEX), which is an interdisciplinary program focusing on the importance of oyster reef communities in the Chesapeake Bay ecosystem. The VORTEX program uses field and laboratory experience supported by multimedia instruction. This document presents an overview on the biology of…

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    David, S.A.; Goodwin, G.M.; Gardner, K.

    This document contains a listing of the written scientific information originating in the Materials Joining (formerly the Welding and Brazing Group), Metals and Ceramics Division, Oak Ridge National Laboratory during 1951 through June 1989. This registry of documents is as much as possible, in the order of issue date. A complete cross-referenced listing of the technical literature of the Metals and Ceramics Division is also available.

  6. Uniform Federal Policy for Quality Assurance Project Plans: Evaluating, Assessing, and Documenting Environmental Data Collection and Use Programs. Part 1. UFP-QAPP Manual

    DTIC Science & Technology

    2004-07-01

    sampler, project manager, data reviewer, statistician , risk assessor, assessment personnel, and laboratory QC manager. In addition, a complete copy of...sample • Corrective actions to be taken if the QC sample fails these criteria • A description of how the QC data and results are to be documented and...Intergovernmental Data Quality Task Force Uniform Federal Policy for Quality Assurance Project Plans Evaluating, Assessing, and Documenting

  7. Publications of the JPL Solar Thermal Power Systems Project, 1976 to 1983

    NASA Technical Reports Server (NTRS)

    Gray, V. (Compiler); Marsh, C. (Compiler); Panda, P. (Compiler)

    1984-01-01

    The bibliographical listings in this publication are documentation products associated with the solar thermal power system project carried out by the Jet Propulsion Laboratory from 1976 to 1983. Documents listed are categorized as conference and journal papers, JPL external reports, JPL internal reports, or contractor reports. Alphabetical listings by title were used in the bibliography itself to facilitate location of the document by subject. Two indexes are included for ease of reference: one, an author index; the other, a topical index.

  8. NASA visual thesaurus maintenance documentation

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The following document is presented in six sections: (1) introduction; (2) a diagram showing how the various routines are grouped together into functional modules; (3) a printout of all the layouts in the system along with their associated layout procedures; (4) listings of all the global procedures in the system; (5) a cross-reference of all identifiers used in the system; and (6) descriptions of the external procedures used in the system. The document was prepared at the Project ICON Image Scaling Laboratory.

  9. 7 CFR 94.5 - Charges for laboratory service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS... costs for analysis of mandatory egg product samples at Science and Technology Division laboratories... program. The costs for any other mandatory laboratory analyses and testing of an egg product's identity...

  10. 7 CFR 94.5 - Charges for laboratory service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS... costs for analysis of mandatory egg product samples at Science and Technology Division laboratories... program. The costs for any other mandatory laboratory analyses and testing of an egg product's identity...

  11. 7 CFR 94.5 - Charges for laboratory service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS... costs for analysis of mandatory egg product samples at Science and Technology Division laboratories... program. The costs for any other mandatory laboratory analyses and testing of an egg product's identity...

  12. 7 CFR 94.5 - Charges for laboratory service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS... costs for analysis of mandatory egg product samples at Science and Technology Division laboratories... program. The costs for any other mandatory laboratory analyses and testing of an egg product's identity...

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    This document comprises Pacific Northwest National Laboratory`s report for Fiscal Year 1996 on research and development programs. The document contains 161 project summaries in 16 areas of research and development. The 16 areas of research and development reported on are: atmospheric sciences, biotechnology, chemical instrumentation and analysis, computer and information science, ecological science, electronics and sensors, health protection and dosimetry, hydrological and geologic sciences, marine sciences, materials science and engineering, molecular science, process science and engineering, risk and safety analysis, socio-technical systems analysis, statistics and applied mathematics, and thermal and energy systems. In addition, this report provides an overview ofmore » the research and development program, program management, program funding, and Fiscal Year 1997 projects.« less

  14. Sandia National Laboratories Advanced Simulation and Computing (ASC) software quality plan. Part 1: ASC software quality engineering practices, Version 2.0.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sturtevant, Judith E.; Heaphy, Robert; Hodges, Ann Louise

    2006-09-01

    The purpose of the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan is to clearly identify the practices that are the basis for continually improving the quality of ASC software products. The plan defines the ASC program software quality practices and provides mappings of these practices to Sandia Corporate Requirements CPR 1.3.2 and 1.3.6 and to a Department of Energy document, ASCI Software Quality Engineering: Goals, Principles, and Guidelines. This document also identifies ASC management and software project teams responsibilities in implementing the software quality practices and in assessing progress towards achieving their software quality goals.

  15. Picatinny Arsenal 3000 Area Laboratory Complex Energy Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brown, Daryl R.; Goddard, James K.

    2010-05-01

    In response to a request by Picatinny Arsenal, the Pacific Northwest National Laboratory (PNNL) was asked by the Army to conduct an energy audit of the Arsenal’s 3000 Area Laboratory Complex. The objective of the audit was to identify life-cycle cost-effective measures that the Arsenal could implement to reduce energy costs. A “walk-through” audit of the facilities was conducted on December 7-8, 2009. Findings and recommendations are included in this document.

  16. Capillary blood sampling: national recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine

    PubMed Central

    Krleza, Jasna Lenicek; Dorotic, Adrijana; Grzunov, Ana; Maradin, Miljenka

    2015-01-01

    Capillary blood sampling is a medical procedure aimed at assisting in patient diagnosis, management and treatment, and is increasingly used worldwide, in part because of the increasing availability of point-of-care testing. It is also frequently used to obtain small blood volumes for laboratory testing because it minimizes pain. The capillary blood sampling procedure can influence the quality of the sample as well as the accuracy of test results, highlighting the need for immediate, widespread standardization. A recent nationwide survey of policies and practices related to capillary blood sampling in medical laboratories in Croatia has shown that capillary sampling procedures are not standardized and that only a small proportion of Croatian laboratories comply with guidelines from the Clinical Laboratory Standards Institute (CLSI) or the World Health Organization (WHO). The aim of this document is to provide recommendations for capillary blood sampling. This document has been produced by the Working Group for Capillary Blood Sampling within the Croatian Society of Medical Biochemistry and Laboratory Medicine. Our recommendations are based on existing available standards and recommendations (WHO Best Practices in Phlebotomy, CLSI GP42-A6 and CLSI C46-A2), which have been modified based on local logistical, cultural, legal and regulatory requirements. We hope that these recommendations will be a useful contribution to the standardization of capillary blood sampling in Croatia. PMID:26524965

  17. Capillary blood sampling: national recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine.

    PubMed

    Krleza, Jasna Lenicek; Dorotic, Adrijana; Grzunov, Ana; Maradin, Miljenka

    2015-01-01

    Capillary blood sampling is a medical procedure aimed at assisting in patient diagnosis, management and treatment, and is increasingly used worldwide, in part because of the increasing availability of point-of-care testing. It is also frequently used to obtain small blood volumes for laboratory testing because it minimizes pain. The capillary blood sampling procedure can influence the quality of the sample as well as the accuracy of test results, highlighting the need for immediate, widespread standardization. A recent nationwide survey of policies and practices related to capillary blood sampling in medical laboratories in Croatia has shown that capillary sampling procedures are not standardized and that only a small proportion of Croatian laboratories comply with guidelines from the Clinical Laboratory Standards Institute (CLSI) or the World Health Organization (WHO). The aim of this document is to provide recommendations for capillary blood sampling. This document has been produced by the Working Group for Capillary Blood Sampling within the Croatian Society of Medical Biochemistry and Laboratory Medicine. Our recommendations are based on existing available standards and recommendations (WHO Best Practices in Phlebotomy, CLSI GP42-A6 and CLSI C46-A2), which have been modified based on local logistical, cultural, legal and regulatory requirements. We hope that these recommendations will be a useful contribution to the standardization of capillary blood sampling in Croatia.

  18. The HIPPO Project Archive: Carbon Cycle and Greenhouse Gas Data

    NASA Astrophysics Data System (ADS)

    Christensen, S. W.; Aquino, J.; Hook, L.; Williams, S. F.

    2012-12-01

    The HIAPER (NSF/NCAR Gulfstream V Aircraft) Pole-to-Pole Observations (HIPPO) project measured a comprehensive suite of atmospheric trace gases and aerosols pertinent to understanding the global carbon cycle from the surface to the tropopause and approximately pole-to-pole over the Pacific Ocean. Flights took place over five missions during different seasons from 2009 to 2011. Data and documentation are available to the public from two archives: (1) NCAR's Earth Observing Laboratory (EOL) provides complete aircraft and flight operational data, and (2) the U.S. DOE's Carbon Dioxide Information Analysis Center (CDIAC) provides integrated measurement data products. The integrated products are more generally useful for secondary analyses. Data processing is nearing completion, although improvements to the data will continue to evolve and analyses will continue many years into the future. Periodic new releases of integrated measurement (merged) products will be generated by EOL when individual measurement data have been updated as directed by the Lead Principal Investigator. The EOL and CDIAC archives will share documentation and supplemental links and will ensure that the latest versions of data products are available to users of both archives. The EOL archive (http://www.eol.ucar.edu/projects/hippo/) provides the underlying investigator-provided data, including supporting data sets (e.g. operational satellite, model output, global observations, etc.), and ancillary flight operational information including field catalogs, data quality reports, software, documentation, publications, photos/imagery, and other detailed information about the HIPPO missions. The CDIAC archive provides integrated measurement data products, user documentation, and metadata through the HIPPO website (http://hippo.ornl.gov). These merged products were derived by consistently combining the aircraft state parameters for position, time, temperature, pressure, and wind speed with meteorological, atmospheric chemistry and aerosol measurements made by several teams of investigators. Files are in ASCII text format. Selected data products have been loaded into a relational database for customized data subsetting and export formatting. We anticipate adding model-generated products to the archive. Metadata records have been compiled into a searchable CDIAC index and have been submitted to climate change research metadata clearinghouses (e.g., GCMD). Each data product is given a complete bibliographic citation and a persistent identifier (DOI) to facilitate attribution and access. A data policy was adopted that balances the needs of the project investigators with the interests of the scientific user community.

  19. Chemicals of emerging concern in water and bottom sediment in Great Lakes areas of concern, 2010 to 2011-Collection methods, analyses methods, quality assurance, and data

    USGS Publications Warehouse

    Lee, Kathy E.; Langer, Susan K.; Menheer, Michael A.; Foreman, William T.; Furlong, Edward T.; Smith, Steven G.

    2012-01-01

    The U.S. Geological Survey (USGS) cooperated with the U.S. Environmental Protection Agency and the U.S. Fish and Wildlife Service on a study to identify the occurrence of chemicals of emerging concern (CECs) in water and bottom-sediment samples collected during 2010–11 at sites in seven areas of concern (AOCs) throughout the Great Lakes. Study sites include tributaries to the Great Lakes in AOCs located near Duluth, Minn.; Green Bay, Wis.; Roches­ter, N.Y.; Detroit, Mich.; Toledo, Ohio; Milwaukee, Wis.; and Ashtabula, Ohio. This report documents the collection meth­ods, analyses methods, quality-assurance data and analyses, and provides the data for this study. Water and bottom-sediment samples were analyzed at the USGS National Water Quality Laboratory in Denver, Colo., for a broad suite of CECs. During this study, 135 environmental and 23 field dupli­cate samples of surface water and wastewater effluent, 10 field blank water samples, and 11 field spike water samples were collected and analyzed. Sixty-one of the 69 wastewater indicator chemicals (laboratory method 4433) analyzed were detected at concentrations ranging from 0.002 to 11.2 micrograms per liter. Twenty-eight of the 48 pharmaceuticals (research method 8244) analyzed were detected at concentrations ranging from 0.0029 to 22.0 micro­grams per liter. Ten of the 20 steroid hormones and sterols analyzed (research method 4434) were detected at concentrations ranging from 0.16 to 10,000 nanograms per liter. During this study, 75 environmental, 13 field duplicate samples, and 9 field spike samples of bottom sediment were collected and analyzed for a wide variety of CECs. Forty-seven of the 57 wastewater indicator chemicals (laboratory method 5433) analyzed were detected at concentrations ranging from 0.921 to 25,800 nanograms per gram. Seventeen of the 20 steroid hormones and sterols (research method 6434) analyzed were detected at concentrations ranging from 0.006 to 8,921 nanograms per gram. Twelve of the 20 pharmaceuticals (research method 8244) analyzed were detected at concentrations ranging from 2.35 to 453.5 nanograms per gram. Six of the 11 antidepressants (research method 9008) analyzed were detected at concentrations ranging from 2.79 to 91.6 nanograms per gram.

  20. New nutritional composition data on selected traditional foods consumed in Black Sea Area countries.

    PubMed

    Costa, Helena S; Albuquerque, Tânia G; Sanches-Silva, Ana; Vasilopoulou, Effie; Trichopoulou, Antonia; D'Antuono, L Filippo; Alexieva, Iordanka; Boyko, Nadiya; Costea, Carmen; Fedosova, Katerina; Hayran, Osman; Karpenko, Dmitry; Kilasonia, Zaza; Finglas, Paul

    2013-11-01

    Traditional foods are an important part of the culture, history, identity and heritage of a region or country and are key elements in dietary patterns. In most countries there is limited information on the nutritional composition of such foods and therefore there is a need to investigate, register and promote traditional foods. One of the aims within the 'Sustainable exploitation of bioactive components from the Black Sea Area traditional foods' (BaSeFood) project is to generate for the first time new data on the nutritional composition of traditional foods from six Black Sea Area countries to promote their sustainable development and exploitation. Thirty-three traditional foods were analysed in an accredited laboratory to determine their nutritional composition, and the data were fully documented. The nutrient content varied widely because of the nature and variety of the analysed foods. The energy content ranged between 4 kcal per 100 g for kvass southern and 900 kcal per 100 g for mustard oil, with the exception of the analysed teas, which did not contribute to energy intake. The use of a common methodology for the study of traditional foods will enable countries to further investigate these foods. Moreover, a new nutritional knowledge base of traditional foods from Black Sea Area countries will contribute to promote local biodiversity and sustainable diets by maintaining healthy dietary patterns within local cultures. © 2013 Society of Chemical Industry.

  1. Combining computational analyses and interactive visualization for document exploration and sensemaking in jigsaw.

    PubMed

    Görg, Carsten; Liu, Zhicheng; Kihm, Jaeyeon; Choo, Jaegul; Park, Haesun; Stasko, John

    2013-10-01

    Investigators across many disciplines and organizations must sift through large collections of text documents to understand and piece together information. Whether they are fighting crime, curing diseases, deciding what car to buy, or researching a new field, inevitably investigators will encounter text documents. Taking a visual analytics approach, we integrate multiple text analysis algorithms with a suite of interactive visualizations to provide a flexible and powerful environment that allows analysts to explore collections of documents while sensemaking. Our particular focus is on the process of integrating automated analyses with interactive visualizations in a smooth and fluid manner. We illustrate this integration through two example scenarios: an academic researcher examining InfoVis and VAST conference papers and a consumer exploring car reviews while pondering a purchase decision. Finally, we provide lessons learned toward the design and implementation of visual analytics systems for document exploration and understanding.

  2. Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process.

    PubMed

    Kaltenthaler, Eva; Carroll, Christopher; Hill-McManus, Daniel; Scope, Alison; Holmes, Michael; Rice, Stephen; Rose, Micah; Tappenden, Paul; Woolacott, Nerys

    2017-06-01

    Evidence Review Groups (ERGs) critically appraise company submissions as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) process. As part of their critique of the evidence submitted by companies, the ERGs undertake exploratory analyses to explore uncertainties in the company's model. The aim of this study was to explore pre-defined factors that might influence or predict the extent of ERG exploratory analyses. The aim of this study was to explore predefined factors that might influence or predict the extent of ERG exploratory analyses. We undertook content analysis of over 400 documents, including ERG reports and related documentation for the 100 most recent STAs (2009-2014) for which guidance has been published. Relevant data were extracted from the documents and narrative synthesis was used to summarise the extracted data. All data were extracted and checked by two researchers. Forty different companies submitted documents as part of the NICE STA process. The most common disease area covered by the STAs was cancer (44%), and most ERG reports (n = 93) contained at least one exploratory analysis. The incidence and frequency of ERG exploratory analyses does not appear to be related to any developments in the appraisal process, the disease area covered by the STA, or the company's base-case incremental cost-effectiveness ratio (ICER). However, there does appear to be a pattern in the mean number of analyses conducted by particular ERGs, but the reasons for this are unclear and potentially complex. No clear patterns were identified regarding the presence or frequency of exploratory analyses, apart from the mean number conducted by individual ERGs. More research is needed to understand this relationship.

  3. Energy Return On Investment of Engineered Geothermal Systems Data

    DOE Data Explorer

    Mansure, Chip

    2012-01-01

    The project provides an updated Energy Return on Investment (EROI) for Enhanced Geothermal Systems (EGS). Results incorporate Argonne National Laboratory's Life Cycle Assessment and base case assumptions consistent with other projects in the Analysis subprogram. EROI is a ratio of the energy delivered to the consumer to the energy consumed to build, operate, and decommission the facility. EROI is important in assessing the viability of energy alternatives. Currently EROI analyses of geothermal energy are either out-of-date, of uncertain methodology, or presented online with little supporting documentation. This data set is a collection of files documenting data used to calculate the Energy Return On Investment (EROI) of Engineered Geothermal Systems (EGS) and erratum to publications prior to the final report. Final report is available from the OSTI web site (http://www.osti.gov/geothermal/). Data in this collections includes the well designs used, input parameters for GETEM, a discussion of the energy needed to haul materials to the drill site, the baseline mud program, and a summary of the energy needed to drill each of the well designs. EROI is the ratio of the energy delivered to the customer to the energy consumed to construct, operate, and decommission the facility. Whereas efficiency is the ratio of the energy delivered to the customer to the energy extracted from the reservoir.

  4. Perspectives of Education for Sustainable Development--Understanding and Introducing the Notion in Polish Educational Documents

    ERIC Educational Resources Information Center

    Czapla, Malgorzata; Berlinska, Agnieszka

    2011-01-01

    The aim of this article is to present an analysis of formal educational documents in the context of the sustainable development notion. This goal was realised by an analysis of the National Curriculum Framework documents from 2002 in comparison with the newest document from 2008. In addition, seven teaching programmes were analysed. On the grounds…

  5. Contents of microscopic fungi in dusts coming from cereal analysis laboratories.

    PubMed

    Szwajkowska-Michalek, Lidia; Stuper, Kinga; Lakomy, Piotr; Matysiak, Anna; Perkowski, Juliusz

    2010-01-01

    Microscopic fungi - components of bioaerosol found in the workplace environment of individuals employed in the agricultural sector - constitute a considerable hazard for their health. This study includes quantitative and qualitative analyses of mycobionta contained in 20 samples of dusts collected from laboratories conducting analyses of cereals. A total of 27 species of viable microscopic fungi were isolated. The most frequently isolated genera Penicillium and Aspergillus, accounting for 27 percent and 26 percent of analyzed isolates. The content of fungal biomass was determined quantitatively using a fungal marker, ergosterol (ERG). Concentrations of this metabolite for all samples ranged from 0.48 mg/kg-212.36 mg/kg. Based on the analyses, it may be stated that the concentration of microfungi in settled dust from laboratories conducting analyses of cereals was varied, and in several cases markedly exceeded admissible concentration levels.

  6. Evaluation of the effectiveness of an outreach clinical mentoring programme in support of paediatric HIV care scale-up in Botswana.

    PubMed

    Workneh, Gelane; Scherzer, Leah; Kirk, Brianna; Draper, Heather R; Anabwani, Gabriel; Wanless, R Sebastian; Jibril, Haruna; Gaetsewe, Neo; Thuto, Boitumelo; Tolle, Michael A

    2013-01-01

    Clinical mentoring by providers skilled in HIV management has been identified as a cornerstone of scaling-up antiretroviral treatment in Africa, particularly in settings where expertise is limited. However, little data exist on its effectiveness and impact on improving the quality-of-care and clinical outcomes, especially for HIV-infected children. Since 2008, the Botswana-Baylor Children's Clinical Centre of Excellence (COE) has operated an outreach mentoring programme at clinical sites around Botswana. This study is a retrospective review of 374 paediatric charts at four outreach mentoring sites (Mochudi, Phutadikobo, Molepolole and Thamaga) evaluating the effectiveness of the programme as reflected in a number of clinically-relevant areas. Charts from one visit prior to initiation of mentoring and from one visit after approximately one year of mentoring were assessed for statistically-significant differences (p<0.05) in the documentation of clinically-relevant indicators. Mochudi showed notable improvements in all indicators analysed, with particular improvements in documentation of pill count, viral load (VL) results, correct laboratory monitoring and correct antiretroviral therapy (ART) dosing (p<0.0001, p<0.0001, p<0.0001 and p<0.0001, respectively). Broad and substantial improvements were also seen in Molepolole, with the most improvement in disclosure documentation of all four sites. At Thamaga, improvements were restricted to CD4 documentation (p<0.001), recent VL and documented pill count (p<0.05 and p<0.05, respectively). Phuthadikobo showed the least amount of improvement across indicators, with only VL documentation and correct ART dosing showing statistically-significant improvements (p<0.05 and p<0.0001, respectively). These findings suggest that clinical mentoring may assist improvements in a number of important areas, including ART dosing and monitoring; adherence assessment and assurance; and disclosure. Clinical mentoring may be a valuable tool in scale-up of quality paediatric HIV care-and-treatment outside specialised centres. Further study will help refine approaches to clinical mentoring, including assuring mentoring translates into improved clinical outcomes for HIV-infected children.

  7. A controlled study of a simulated workplace laboratory for adults with attention deficit hyperactivity disorder.

    PubMed

    Fried, Ronna; Surman, Craig; Hammerness, Paul; Petty, Carter; Faraone, Stephen; Hyder, Laran; Westerberg, Diana; Small, Jacqueline; Corkum, Lyndsey; Claudat, Kim; Biederman, Joseph

    2012-12-30

    Despite an extant literature documenting that adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for significant difficulties in the workplace, there is little documentation of the underlying factors associated with these impairments. The main aim of this study was to examine specific deficiencies associated with ADHD on workplace performance in a simulated workplace laboratory relative to controls. Participants were 56 non-medicated young adults with DSM-IV ADHD and 63 age- and sex-matched controls without ADHD. Participants spent 10h in a workplace simulation laboratory. Areas assessed included: (1) simulated tasks documented in a government report (SCANS) often required in workplace settings (taxing vigilance; planning; cooperation; attention to detail), (2) observer ratings, and (3) self-reports. Robust findings were found in the statistically significant differences on self-report of ADHD symptoms found between participants with ADHD and controls during all workplace tasks and periods of the workday. Task performance was found to be deficient in a small number of areas, and there were a few statistically significant differences identified by observer ratings. Symptoms reported by participants with ADHD in the simulation including internal restlessness, intolerance of boredom and difficulty maintaining vigilance were significant and could adversely impact workplace performance over the long-term. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  8. Pre-examination factors affecting molecular diagnostic test results and interpretation: A case-based approach.

    PubMed

    Payne, Deborah A; Baluchova, Katarina; Peoc'h, Katell H; van Schaik, Ron H N; Chan, K C Allen; Maekawa, Masato; Mamotte, Cyril; Russomando, Graciela; Rousseau, François; Ahmad-Nejad, Parviz

    2017-04-01

    Multiple organizations produce guidance documents that provide opportunities to harmonize quality practices for diagnostic testing. The International Organization for Standardization ISO 15189 standard addresses requirements for quality in management and technical aspects of the clinical laboratory. One technical aspect addresses the complexities of the pre-examination phase prior to diagnostic testing. The Committee for Molecular Diagnostics of the International Federation for Clinical Chemistry and Laboratory Medicine (also known as, IFCC C-MD) conducted a survey of international molecular laboratories and determined ISO 15189 to be the most referenced guidance document. In this review, the IFCC C-MD provides case-based examples illustrating the value of select pre-examination processes as these processes relate to molecular diagnostic testing. Case-based examples in infectious disease, oncology, inherited disease and pharmacogenomics address the utility of: 1) providing information to patients and users, 2) designing requisition forms, 3) obtaining informed consent and 4) maintaining sample integrity prior to testing. The pre-examination phase requires extensive and consistent communication between the laboratory, the healthcare provider and the end user. The clinical vignettes presented in this paper illustrate the value of applying select ISO 15189 recommendations for general laboratory to the more specialized area of Molecular Diagnostics. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Chemical Studies of Free Radical Relocalization

    DTIC Science & Technology

    2015-01-13

    Park, NC 27709-2211 combustion intermediates, rel;ocalization, infrared spectroscopy , computational quantum chemistry REPORT DOCUMENTATION PAGE 11...organotransition metal catalysis are underway. Summary of important results: I. Laboratory Spectroscopy of Gas-phase Hydrocarbon Radicals. We have carried out line...combination of gas-phase laboratory spectroscopy , photochemical studies, and ab initio computations. (1) Spectroscopy . Survey scans between 1800 and

  10. Cloud Migration Experiment Configuration and Results

    DTIC Science & Technology

    2017-12-01

    ARL-TR-8248 ● DEC 2017 US Army Research Laboratory Cloud Migration Experiment Configuration and Results by Michael De Lucia...or reconstruction of the document. ARL-TR-8248 ● DEC 2017 US Army Research Laboratory Cloud Migration Experiment Configuration...and Results by Michael De Lucia Computational and Information Sciences Directorate, ARL Justin Wray and Steven S Collmann ICF International

  11. The CGE-PLATO Electronic Laboratory Instructional Programs. (August 1, 1972 Through June 30, 1975).

    ERIC Educational Resources Information Center

    Neal, J. P.

    Twelve PLATO lessons are reproduced in this document to show the status of computer guided experimentation (CGE) instructional programs. The lesson topics include a description of the CGE-PLATO instructional laboratory, an introduction to CGE-PLATO tests and special software routines, router lesson for two electrical engineering courses, and an…

  12. A Guide for Planning Facilities for Occupational Preparation Programs for Dental Laboratory Technicians. Research Series No. 34.

    ERIC Educational Resources Information Center

    Macconnell, James D., And Others

    The twelfth in a series also including guides for facilities for medical x-ray technologist, medical assistant, and medical secretary programs, the document is intended for use in the preparation of educational specifications for facilities for dental laboratory technician programs. Designed for use by those responsible for planning facilities,…

  13. Bringing Research into a First Semester Organic Chemistry Laboratory with the Multistep Synthesis of Carbohydrate-Based HIV Inhibitor Mimics

    ERIC Educational Resources Information Center

    Pontrello, Jason K.

    2015-01-01

    Benefits of incorporating research experiences into laboratory courses have been well documented, yet examples of research projects designed for the first semester introductory organic chemistry lab course are extremely rare. To address this deficiency, a Carbohydrate-Based human immunodeficiency virus (HIV) Inhibitor project consisting of a…

  14. 75 FR 22150 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal Agencies Correction In notice document 2010-7170 beginning on page 16813 in the issue of Friday, April 2...

  15. AFHRL/FT [Air Force Human Resources Laboratory/Flight Training] Capabilities in Undergraduate Pilot Training Simulation Research: Executive Summary.

    ERIC Educational Resources Information Center

    Matheny, W. G.; And Others

    The document presents a summary description of the Air Force Human Resource Laboratory's Flying Training Division (AFHRL/FT) research capabilities for undergraduate pilot training. One of the research devices investigated is the Advanced Simulator for Undergraduate Pilot Training (ASUPT). The equipment includes the ASUPT, the instrumented T-37…

  16. Laboratory Management for Cosmetology Instruction: A Management Guide for Teachers.

    ERIC Educational Resources Information Center

    Virginia Polytechnic Inst. and State Univ., Blacksburg. Div. of Vocational-Technical Education.

    A collection of materials to aid cosmetology teachers in organizing and managing laboratory/classrooms is presented in the document. The materials may be adapted for use in a variety of situations and have been compiled by a group of cosmetology instructors. Materials are presented in two ways, with the first providing a discussion of topics which…

  17. Regional Educational Laboratory Approaches to Educational Improvement: A Descriptive Synthesis.

    ERIC Educational Resources Information Center

    Mason, Ward S.

    This study describes the nine regional educational laboratories supported by the Office of Educational Research and Improvement (OERI). The labs are operating under 5-year contracts for 1986-1990. The study analyzed lab-produced documents, describing lab operation for the first 2 years of this period, highlighting the status of the program at the…

  18. Operational Concepts for a Generic Space Exploration Communication Network Architecture

    NASA Technical Reports Server (NTRS)

    Ivancic, William D.; Vaden, Karl R.; Jones, Robert E.; Roberts, Anthony M.

    2015-01-01

    This document is one of three. It describes the Operational Concept (OpsCon) for a generic space exploration communication architecture. The purpose of this particular document is to identify communication flows and data types. Two other documents accompany this document, a security policy profile and a communication architecture document. The operational concepts should be read first followed by the security policy profile and then the architecture document. The overall goal is to design a generic space exploration communication network architecture that is affordable, deployable, maintainable, securable, evolvable, reliable, and adaptable. The architecture should also require limited reconfiguration throughout system development and deployment. System deployment includes: subsystem development in a factory setting, system integration in a laboratory setting, launch preparation, launch, and deployment and operation in space.

  19. Tissues from the irradiated dog/mouse archive

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gayle Woloschak

    The purpose of this project is to organize the databases/information and organize and move the tissues from the long-term dog (4,000 dogs) and mouse (over 30,000 mice) radiation experiments done at Argonne National Laboratory during the 1970's and 80's to Northwestern University. These studies were done with the intention of understanding the effects of exposure to radiation at a variety of different doses, dose-rates, and radiation qualities on end-points such as life-shortening, carcinogenesis, cause of death, shifts in disease incidence and other biological parameters. Organ and tissue samples from these animals including cancers, metastases and other significant degenerative and inflammatorymore » lesions and those in a regular protocol of normal tissues were preserved in paraffin blocks, tissue impressions and sections and represent a great resource for the radiation biology community. These collections are particularly significant since these experiments are not likely to be repeated because of the extreme cost of monies and time for such large-scale animal studies. The long-term goal is to make these tissues and databases available to the wider scientific community so that questions such as tissue sensitivity, early and late effects, low dose and protracted dose responses of normal and tumor tissues, etc. can be examined and defined. Recent advances in biology particularly at the subcellular and molecular level now permit microarray-based gene expression array analyses from paraffin-embedded tissues (where RNA samples are significantly degraded), synchrotron-based studies of metal and other elemental distribution patterns in tissues, PCR-based analyses for mutation detection, and other similar approaches that were not available when the long¬ term animal studies were designed and initiated. Understanding the basis and progression of radiation damage should also permit rational approaches to prevention and mitigation of those damages. Therefore, as stated earlier, these tissues and their related documentation, represent a significant resource for future studies. For this project, we propose to accomplish the following objectives: (1) inventory and organize the tissues, blood smears, wet-tissues and paper-¬based information that is available in the tissue bank at Argonne National Laboratory; (2) convert the existing Oracle database of the mouse studies to MS Access( the dog data is already in this format which is far more user friendly and widely used in business and research) , (3) move the remaining samples and documentation from dogs that had been transferred from ANL to New Mexico (in Dr. F. Hahn's care) to Northwestern University and add these to the inventory; (4) move the tissues and Access database at Argonne National Laboratory to Northwestern University.« less

  20. List of DOE radioisotope customers with summary of radioisotope shipments, FY 1979

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burlison, J.S.

    1980-06-01

    The fifteenth edition of the radioisotope customer list was prepared at the request of the Division of Financial Services, Office of the Assistant Secretary for Environment, Department of Energy (DOE). This document lists DOE's radioisotope production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Rocky Flats Area Office; Savannah River Laboratory; and UNC Nuclear Industries, Inc. The information is divided into five sections: Isotope suppliers, facility, contracts and isotopes or services supplied; alphabetical list ofmore » customers, and isotopes purchased; alphabetical list of isotopes cross-referenced to customer numbers; geographical location of radioisotope customers; and radioisotope sales and transfers-FY 1979.« less

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