Distribution of Magma and Hydrothermal Fluids Beneath the Laguna del Maule Volcanic Field, Central Chile Using Magnetotelluric Data

NASA Astrophysics Data System (ADS)

Unsworth, M. J.; Cordell, D. R.; Diaz, D.; Reyes, V.

2016-12-01

Geodetic data has shown that the surface around the Laguna del Maule volcanic field in central Chile has been moving upwards at rates in excess of 19 cm/yr since 2007 over a 200 km2 area. It has been hypothesized that this ground deformation is due to the inflation of a magma body beneath the lake. InSAR deformation modeling and gravity inversion suggest that the depth to the magma body is between 3 km b.s.l. and 0 km (at sea level). This magma body is a likely source for the large number of rhyolitic eruptions at this location over the last 25 ka. A dense broadband magnetotelluric (MT) array was collected from 2009 to 2015 and inverted using the ModEM inversion algorithm to produce a three-dimensional electrical resistivity model. The presence of a large surface conductor (<0.5 Ωm; 2.3 km a.s.l.) spatially coincident with the lake bed has the potential to attenuate signal and decrease resolution beneath the area of inflation. Additional broadband MT data were collected in 2016 and this new data suggest there is a mid-depth, weakly conductive feature (5 Ωm; 1 km b.s.l.) coincident with the area of maximum inflation which is resolvable despite the low-resistivity surface layer. There are many conductive features which lie on the perimeter of the zone of inflation including a large low-resistivity zone (<5 Ωm) at 5 km depth (3 km b.s.l.) north-west of the lake and a large low-resistivity zone (<10 Ωm) at 5 km depth (3 km b.s.l) north of the lake. The complex, three-dimensional model structure is supported by phase tensor analysis showing poorly-defined strike and high beta skew values (>3) at periods >2 s. The conductive features identified could be interpreted as either hydrothermal systems or magma and further analysis will contribute to better understanding this dynamic system.

77 FR 49455 - Proclaiming Certain Lands as an Addition to and Becoming a Part of the Laguna Reservation for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

... Laguna, New Mexico. FOR FURTHER INFORMATION CONTACT: Ben Burshia, Bureau of Indian Affairs, Division of... membership. Pueblo of Laguna Indian Reservation Cibola County, New Mexico Those certain parcels of land known..., NEW MEXICO, DECEMBER 1999'', certified on December 2, 1999, by Garry P. Hugg, New Mexico Professional...

Imaging the Laguna del Maule Volcanic Field, central Chile using magnetotellurics: Evidence for crustal melt regions laterally-offset from surface vents and lava flows

NASA Astrophysics Data System (ADS)

Cordell, Darcy; Unsworth, Martyn J.; Díaz, Daniel

2018-04-01

Magnetotelluric (MT) data were collected at the Laguna del Maule volcanic field (LdMVF), located in central Chile (36°S, 70.5°W), which has been experiencing unprecedented upward ground deformation since 2007. These data were used to create the first detailed three-dimensional electrical resistivity model of the LdMVF and surrounding area. The resulting model was spatially complex with several major conductive features imaged at different depths and locations around Laguna del Maule (LdM). A near-surface conductor (C1; 0.5 Ωm) approximately 100 m beneath the lake is interpreted as a conductive smectite clay cap related to a shallow hydrothermal reservoir. At 4 km depth, a strong conductor (C3; 0.3 Ωm) is located beneath the western edge of LdM. The proximity of C3 to the recent Pleistocene-to-Holocene vents in the northwest LdMVF and nearby hot springs suggests that C3 is a hydrous (>5 wt% H2O), rhyolitic partial melt with melt fraction >35% and a free-water hydrothermal component. C3 dips towards, and is connected to, a deeper conductor (C4; 1 Ωm). C4 is located to the north of LdM at >8 km depth below surface and is interpreted as a long-lived, rhyolitic-to-andesitic magma reservoir with melt fractions less than 35%. It is hypothesized that the deeper magma reservoir (C4) is providing melt and hydrothermal fluids to the shallower magma reservoir (C3). A large conductor directly beneath the LdMVF is not imaged with MT suggesting that any mush volume beneath LdM must be anhydrous (<2 wt% H2O), low temperature and low melt fraction (<25%) in order to go undetected. The presence of large conductors to the north has important implications for magma dynamics as it suggests that material may have a significant lateral component (>10 km) as it moves from the deep magma reservoir (C4) to create small, ephemeral volumes of eruptible melt (C3). It is hypothesized that there may be a north-south contrast in physical processes affecting the growth of melt-rich zones

Large rock avalanches in southern Perù: the Cerro Caquilluco - Cerrillos Negros rock slide - avalanche (Tacna, Tomasiri, Perù)

NASA Astrophysics Data System (ADS)

Crosta, G.; Hermanns, R. L.; Murillo, P. V.

2012-04-01

The Andean bent which coincides with the Peruvian-Chilean border region is characterised by one of the largest relief contrasts on earth with depth of the subduction trench ranging from 5000 to 6000 m below sea level and mountain tops ranging from 5500 to 6300 m a.s.l.. The western flank of the Andes is subdivided in 4 major geologic zones (i.e. Coastal Cordillera, longitudinal Basin or depression, the Precordillera or western escarpment and western Cordillera). Local relief contrasts are also pronounced due to the incision of deep canyons into several million old uplifted surfaces, preserved because of the extremely dry climate with precipitation averaging a few mm and less per year. The Lluta collapse (minimum age of 2.5 Ma; volume 26 km3) is one of the largest non-volcanic non-marine landslides on Earth and has been mapped in that area (Wörner et al., 2002). Systematic mapping in northern Chile and Southern Peru has revealed that this is not the only gigantic landslide in the area but that further landslides of similar size occurred in the area, located both along the canyon slopes and along the western escarpment of the Cordillera. This suggests that landsliding has been a major factor in controlling erosion. This contribution describes first results on mapping a giant landslide complex in southern Perù called the Cerro Caquilluco - Cerrillos Negros Tomasiri rock slide - avalanche complex. The systematic mapping we have carried out in the area is presented in a further contribution to this conference. The Cerro Caquilluco - Cerrillos Negros Tomasiri rock slide - avalanche complex affected the upper part of a SW dipping paleosurface (8° to 9°) cut by a disconnected and regular primitive drainage network organized in a series of SW trending parallel valleys. This network developed within the lower Miocene pinkish tuffaceous deposits of the Huaylillas formation, whereas the main landslide scarp lies within the conglomerates of the Upper Moquegua formation

Winter distributions of North American Plovers in the Laguna Madre regions of Tamaulipas, Mexico and Texas, USA

USGS Publications Warehouse

Mabee, Todd J.; Plissner, Jonathan H.; Haig, Susan M.; Goossen, J.P.

2001-01-01

To determine the distribution and abundance of wintering plovers in the Laguna Madre of Texas and Tamaulipas, surveys were conducted in December 1997 and February 1998, along a 160 km stretch of barrier islands in Mexico and- 40 km of shoreline on South Padre Island, Texas. Altogether, 5,673 individuals, representing six plover species, were recorded during the surveys. Black-bellied Plovers Pluvialis squatarola were the most numerous (3 ,013 individuals) representing 53% of the total number of plovers observed. Numbers of Piping Charadriusm elodu, Snowy C . alexandrinus, Semipalmated C. semipalmatus and Wilson's Plovers C. wilsonia were 739, 1,345, 561, and 13 birds, respectively. Most individuals (97%) of all species except Wilson's Plovers were observed on bayside flats of the barrier islands. Similar numbers of Piping Plovers were recorded at South Padre Island, Texas, and in the Laguna Madre de Tamaulipas. Over 85% of the individuals of each of the other species were found in the more extensively surveyed Mexico portion of Laguna Madre. In Tamaulipas, most plover species were observed more often on algal flats than any other substrate. These results provide evidence of the value of these systems as wintering areas for plover species and indicate the need for more extensive survey efforts to determine temporal and spatial variation in the distribution of these species within the Laguna ecosystem.

Rapid uplift during 2007-2012 at Laguna del Maule volcanic field, Andean Southern Volcanic Zone, Chile

NASA Astrophysics Data System (ADS)

Le Mevel, H.; Feigl, K.; Ali, T.; Cordova V., M. L.; DeMets, C.; Singer, B. S.

2012-12-01

The Laguna del Maule (LdM) volcanic field includes an unusual concentration of post-glacial rhyolitic lava coulees and domes, dated between 24 to 2 thousand years old that cover more than 100 square kilometers and erupted from 24 vents that encircle a 20-km-diameter lake basin on the range crest. The recent concentration of rhyolite is unparalleled in the Southern Volcanic Zone of the Andes. Moreover, the western portion of the LdM volcanic field has experienced rapid uplift since 2007, leading to questions about the current configuration of the magmatic system and processes that drive the ongoing inflation. We aim to quantify the active deformation of the LdM volcanic field and its evolution with time. To do so, we use interferometric synthetic aperture radar (InSAR) data acquired by three satellite missions: Envisat in 2003 and 2004, ALOS between 2007 and 2010, and TerraSAR-X in 2012. An interferogram spanning March 2003 to February 2004 "shows no deformation" (Fournier et al., 2010). From 2007 through 2012, however, the shortening of the satellite-to-ground distance revealed a range change rate of greater than 200 mm/yr along the radar line of sight. The deformation includes a circular area 20 km in diameter centered on the western portion of the circle of young rhyolite domes. To analyze the InSAR results, we employ the General Inversion for Phase Technique (GIPhT; Feigl and Thurber, 2009; Ali and Feigl, 2012). We have considered several hypotheses to interpret this deformation. Artefacts such as orbital errors, atmospheric perturbations or topographic contribution cannot account for the observed signal. We also reject the hypothesis of uplift due to gravitational unloading of the crust based on our modeling of independently measured lake level variations over the observed time interval. We thus attribute the deformation to the intrusion of magma into the upper crust below the southwest region of the LdM volcanic field. The best fit to the InSAR data is

The microbial community at Laguna Figueroa, Baja California Mexico - From miles to microns

NASA Technical Reports Server (NTRS)

Stolz, J. F.

1985-01-01

The changes in the composition of the stratified microbial community in the sediments at Laguna Figeroa following floods are studied. The laguna which is located on the Pacific coast of the Baja California peninsula 200 km south of the Mexican-U.S. border is comprised of an evaporite flat and a salt marsh. Data collected from 1979-1983 using Landsat imagery, Skylab photographs, and light and transmission electron microscopy are presented. The flood conditions, which included 1-3 m of meteoric water covering the area and a remanent of 5-10 cm of siliciclastic and clay sediment, are described. The composition of the community prior to the flooding consisted of Microcoleus, Phormidium sp., a coccoid cynanobacteria, Phloroflexus, Ectothiorhodospira, Chloroflexus, Thiocapsa sp., and Chromatium. Following the floods Thiocapsa, Chromatium, Oscillatora sp., Spirulina sp., and Microcoleus are observed in the sediments.

The Cerrillos Uplift, the La Bajada Constriction, and Hydrogeologic Framework of the Santo Domingo Basin, Rio Grande Rift, New Mexico

USGS Publications Warehouse

Minor, Scott A.

2006-01-01

The geologic, geophysical, and hydrogeologic properties of the La Bajada constriction and Santo Domingo Basin, northern New Mexico, result from tectonic and volcanic processes of the late Tertiary and Quaternary Rio Grande rift. An integrated geologic and geophysical assessment in the La Bajada constriction allows development of a geologic framework that can provide input for regional ground-water flow models. These models then can provide better estimates of future water supplies in a region that largely subsists on aquifers in Rio Grande rift basins. The combination of surface geologic investigations (stratigraphic and structural studies; chapters A, B, C, and E), airborne geophysics (aeromagnetic and time-domain electromagnetic surveys; chapters D and F), ground geophysical measurements (gravity and magnetotelluric surveys; chapters D and F), and data from the few wells in the area (chapter G) provides new constraints on the hydrogeologic framework of this area. Summary results of our investigations are synthesized in chapter G. Through-going aquifers consisting of ancestral Rio Grande axial-river sand and gravel and of coarse western-piedmont gravel form the predominant ground-water pathways through the partly buried structural trough defining the La Bajada constriction between Espa?ola and Santo Domingo Basins. Thick, clay-rich Cretaceous marine shales of low hydraulic conductivity form a pervasive regional confining unit within the Cerrillos uplift on the southeast flank of the constriction. Numerous, dominantly north-northwest-striking, intrabasin faults that project part way across the La Bajada constriction create a matrix of laterally and vertically variable hydrogeologic compartments that locally partition and deflect ground-water flow parallel to faults.

Rapid uplift in Laguna del Maule volcanic field of the Andean Southern Volcanic zone (Chile) 2007-2012

NASA Astrophysics Data System (ADS)

Feigl, Kurt L.; Le Mével, Hélène; Tabrez Ali, S.; Córdova, Loreto; Andersen, Nathan L.; DeMets, Charles; Singer, Bradley S.

2014-02-01

The Laguna del Maule (LdM) volcanic field in Chile is an exceptional example of postglacial rhyolitic volcanism in the Southern Volcanic Zone of the Andes. By interferometric analysis of synthetic aperture radar (SAR) images acquired between 2007 and 2012, we measure exceptionally rapid deformation. The maximum vertical velocity exceeds 280 mm yr-1. Although the rate of deformation was negligible from 2003 January to 2004 February, it accelerated some time before 2007 January. Statistical testing rejects, with 95 per cent confidence, four hypotheses of artefacts caused by tropospheric gradients, ionospheric effects, orbital errors or topographic relief, respectively. The high rate of deformation is confirmed by daily estimates of position during several months in 2012, as measured by analysis of signals transmitted by the Global Positioning System (GPS) and received on the ground at three stations around the reservoir forming the LdM. The fastest-moving GPS station (MAU2) has a velocity vector of [-180 ± 4, 46 ± 2, 280 ± 4] mm yr-1 for the northward, eastward and upward components, respectively, with respect to the stable interior of the South America Plate. The observed deformation cannot be explained by changes in the gravitational load caused by variations in the water level in the reservoir. For the most recent observation time interval, spanning 44 d in early 2012, the model that best fits the InSAR observations involves an inflating sill at a depth of 5.2 ± 0.3 km, with length 9.0 ± 0.3 km, width 5.3 ± 0.4 km, dip 20 ± 3° from horizontal and strike 14 ± 5° clockwise from north, assuming a rectangular dislocation in a half-space with uniform elastic properties. During this time interval, the estimated rate of tensile opening is 1.1 ± 0.04 m yr-1, such that the rate of volume increase in the modelled sill is 51 ± 5 million m3 yr-1 or 1.6 ± 0.2 m3 s-1. From 2004 January to 2012 April the total increase in volume was at least 0.15 km3 over the 5.2-yr

Set-up of a decision support system to support sustainable development of the Laguna de Bay, Philippines.

PubMed

Nauta, Tjitte A; Bongco, Alicia E; Santos-Borja, Adelina C

2003-01-01

Over recent decades, population expansion, deforestation, land conversion, urbanisation, intense fisheries and industrialisation have produced massive changes in the Laguna de Bay catchment, Philippines. The resulting problems include rapid siltation of the lake, eutrophication, inputs of toxics, flooding problems and loss of biodiversity. Rational and systematic resolution of conflicting water use and water allocation interests is now urgently needed in order to ensure sustainable use of the water resources. With respect to the competing and conflicting pressures on the water resources, the Laguna Lake Development Authority (LLDA) needs to achieve comprehensive management and development of the area. In view of these problems and needs, the Government of the Netherlands was funding a two-year project entitled 'Sustainable Development of the Laguna de Bay Environment'.A comprehensive tool has been developed to support decision-making at catchment level. This consists of an ArcView GIS-database linked to a state-of-the-art modelling suite, including hydrological and waste load models for the catchment area and a three-dimensional hydrodynamic and water quality model (Delft3D) linked to a habitat evaluation module for the lake. In addition, MS Office based tools to support a stakeholder analysis and financial and economic assessments have been developed. The project also focused on technical studies relating to dredging, drinking water supply and infrastructure works. These aimed to produce technically and economically feasible solutions to water quantity and quality problems. The paper also presents the findings of a study on the development of polder islands in the Laguna de Bay, addressing the water quantity and quality problems and focusing on the application of the decision support system.

Possibilities For The LAGUNA Projects At The Fréjus Site

NASA Astrophysics Data System (ADS)

Mosca, Luigi

2010-11-01

The present laboratory (LSM) at the Fréjus site and the project of a first extension of it, mainly aimed at the next generation of dark matter and double beta decay experiments, are briefly reviewed. Then the main characteristics of the LAGUNA cooperation and Design Study network are summarized. Seven underground sites in Europe are considered in LAGUNA and are under study as candidates for the installation of Megaton scale detectors using three different techniques: a liquid Argon TPC (GLACIER), a liquid scintillator detector (LENA) and a Water Cerenkov (MEMPHYS), all mainly aimed at investigation of proton decay and properties of neutrinos from SuperNovae and other astrophysical sources as well as from accelerators (Super-beams and/or Beta-beams from CERN). One of the seven sites is located at Fréjus, near the present LSM laboratory, and the results of its feasibility study are presented and discussed. Then the physics potential of a MEMPHYS detector installed in this site are emphasized both for non-accelerator and for neutrino beam based configurations. The MEMPHYNO prototype with its R&D programme is presented. Finally a possible schedule is sketched.

History and current safety measures at Laguna Palcacocha, Huaraz, Peru

NASA Astrophysics Data System (ADS)

Salazar Checa, César; Cochachin, Alejo; Frey, Holger; Huggel, Christian; Portocarrero, César

2017-04-01

Laguna Palcacocha is a large glacier lake in the Cordillera Blanca, Peru, located in the Quillcay catchment, above the city of Huaraz, the local capital. On 13 December 1941, the moraine dam lake collapsed, probably after having been impacted by a large ice avalanche, and triggered a major outburst flood. This GLOF destroyed about a third of the city of Huaraz, causing about 2,000 casualties and is therefore one of the deadliest glacier lake outbursts known in history. In 1974, the Glaciology Unit of Peru, responsible for the studying, monitoring and mitigation works related to glacier hazards installed a reinforcement of the natural moraine dam of the newly filled Laguna Palcacocha, with an artificial drainage channel at 7 m below the crest of the reinforced dam. At that time, the lake had an area of 66,800 m2 and a volume of 0.5 x 106 m3. During the past decades, in the course of continued glacier retreat, Laguna Palcacocha has undergone an extreme growth. In February 2016, the lake had an area of 514,000 m2 (7.7 times the area of 1974) and a volume of more than 17 x 106 m3 (more than 34 times the volume of 1974). At the same time, the city of Huaraz, located 20 km downstream of the lake, grew significantly after its almost complete destruction by the 1970 earthquake. Today, about 120,000 people are living in the city. Due to the persisting possibility for large ice avalanches directly above the Palcacocha lake, this constitutes a high-risk situation, requiring new hazard and risk mitigation measures. As an immediate temporal measure, in order to bridge the time until the realization of a more permanent measure, a syphoning system has been installed in 2011, using about ten 700-m pipes with a 10-inch (25.4 cm) diameter. The aim of this syphoning attempt is to lower the lake level by about 7 m, and therefore reduce the lake volume on the one hand, and also reach a higher dam freeboard. However, the system is less effective than assumed, currently the lake level

Crustal seismicity associated to rpid surface uplift at Laguna del Maule Volcanic Complex, Southern Volcanic Zone of the Andes

NASA Astrophysics Data System (ADS)

Cardona, Carlos; Tassara, Andrés; Gil-Cruz, Fernando; Lara, Luis; Morales, Sergio; Kohler, Paulina; Franco, Luis

2018-03-01

Laguna del Maule Volcanic Complex (LMVC, Southern Andes of Chile) has been experiencing large rates (ca. 30 cm/yr) of surface uplift as detected since 2008 by satellite geodetic measurements. Previous works have modeled the source of this deformation as an inflating rectangular sub-horizontal sill underlying LMVC at 5 km depth, which is supposedly related to an active process of magmatic replenishment of a shallow silicic reservoir. However little is known about the tectonic context on which this activity is taking place, particularly its relation with crustal seismicity that could help understanding and monitoring the current deformation process. Here we present the first detailed characterization of the seismic activity taking place at LMVC and integrate it with structural data acquired in the field in order to illuminate the possible connection between the ongoing process of surface uplift and the activation of crustal faults. Our main finding is the recognition of repetitive volcano-tectonic (VT) seismic swarms that occur periodically between 2011 and 2014 near the SW corner of the sill modeled by InSAR studies. A cross-correlation analysis of the waveforms recorded for these VT events allows identifying three different seismic families. Families F1 and F3 share some common features in the stacked waveform and its locations, which markedly differ from those of family F2. Swarms belonging to this later family are more energetic and its energy was increasing since 2011 to a peak in January 2013, which coincide with maximum vertical velocities detected by local GPS stations. This points to a common process relating both phenomena. The location of VT seismic swarms roughly coincides with the intersection of a NE-SW lineament with a WNW-ESE lineament. The former shows clear field evidences of dextral strike-slip that are fully consistent with one nodal plane of focal mechanism for well-recorded F2 events. The conjugate nodal plane of these focal mechanisms could

Morphometric or morpho-anatomal and genetic investigations highlight allopatric speciation in Western Mediterranean lagoons within the Atherina lagunae species (Teleostei, Atherinidae)

NASA Astrophysics Data System (ADS)

Trabelsi, M.; Maamouri, F.; Quignard, J.-P.; Boussaïd, M.; Faure, E.

2004-12-01

Current distribution of Atherina lagunae poses an interesting biogeographical problem as this species inhabits widely separate circum-Mediterranean lagoons. Statistical analyses of 87 biometric parameters and genetic variation in a portion of the cytochrome b gene were examined in four populations of A. lagunae from Tunisian and French lagoons. The results suggested a subdivision into two distinct Atherinid groups: one included the French lagoonal sand smelts and the second included the Tunisian ones. Tunisian lagoonal sand smelts were distinguished from the French ones by the lower number of lateral line scales, vertebrae, pectorals and first dorsal fin rays and the higher number of lower and total gillrakers. In addition, A. lagunae from Tunisian lagoons are characterised by short preorbital length, developed operculum, broad interorbital space, larger head, robust body and a relatively small first dorsal fin which is positioned backwards. In addition, intraspecific sequence variation in a portion of the cytochrome b gene was examined in 87 individuals from Tunisia and France. The high correlation between the results of the molecular phylogenetic tree and biometric statistical data analysis suggested that two different sibling species or at least sub-species or semi-species have colonised the lagoons. In addition, our analyses suggested that the evolution of A. lagunae probably occurred in two steps including marine sympatric speciation within the large Atherina boyeri complex and a post-Pleistocene colonisation of the lagoons.

Magma injection into a long-lived reservoir to explain geodetically measured uplift: Application to the 2007-2014 unrest episode at Laguna del Maule volcanic field, Chile.

PubMed

Le Mével, Hélène; Gregg, Patricia M; Feigl, Kurt L

2016-08-01

Moving beyond the widely used kinematic models for the deformation sources, we present a new dynamic model to describe the process of injecting magma into an existing magma reservoir. To validate this model, we derive an analytical solution and compare its results to those calculated using the Finite Element Method. A Newtonian fluid characterized by its viscosity, density, and overpressure (relative to the lithostatic value) flows through a vertical conduit, intruding into a reservoir embedded in an elastic domain, leading to an increase in reservoir pressure and time-dependent surface deformation. We apply our injection model to Interferometric Synthetic Aperture Radar (InSAR) data from the ongoing unrest episode at Laguna del Maule (Chile) volcanic field that started in 2007. Using a grid search optimization, we minimize the misfit to the InSAR displacement data and vary the three parameters governing the analytical solution: the characteristic timescale τ P for magma propagation, the maximum injection pressure, and the inflection time when the acceleration switches from positive to negative. For a spheroid with semimajor axis a = 6200 m, semiminor axis c = 100 m, located at a depth of 4.5 km in a purely elastic half-space, the best fit to the InSAR displacement data occurs for τ P =9.5 years and an injection pressure rising up to 11.5 MPa for 2 years. The volume flow rate increased to 1.2 m 3 /s for 2 years and then decreased to 0.7 m 3 /s in 2014. In 7.3 years, at least 187 × 10 6 m 3 of magma was injected.

Magma injection into a long-lived reservoir to explain geodetically measured uplift: Application to the 2007-2014 unrest episode at Laguna del Maule volcanic field, Chile

NASA Astrophysics Data System (ADS)

Le Mével, Hélène; Gregg, Patricia M.; Feigl, Kurt L.

2016-08-01

Moving beyond the widely used kinematic models for the deformation sources, we present a new dynamic model to describe the process of injecting magma into an existing magma reservoir. To validate this model, we derive an analytical solution and compare its results to those calculated using the Finite Element Method. A Newtonian fluid characterized by its viscosity, density, and overpressure (relative to the lithostatic value) flows through a vertical conduit, intruding into a reservoir embedded in an elastic domain, leading to an increase in reservoir pressure and time-dependent surface deformation. We apply our injection model to Interferometric Synthetic Aperture Radar (InSAR) data from the ongoing unrest episode at Laguna del Maule (Chile) volcanic field that started in 2007. Using a grid search optimization, we minimize the misfit to the InSAR displacement data and vary the three parameters governing the analytical solution: the characteristic timescale τP for magma propagation, the maximum injection pressure, and the inflection time when the acceleration switches from positive to negative. For a spheroid with semimajor axis a = 6200 m, semiminor axis c = 100 m, located at a depth of 4.5 km in a purely elastic half-space, the best fit to the InSAR displacement data occurs for τP=9.5 years and an injection pressure rising up to 11.5 MPa for 2 years. The volume flow rate increased to 1.2 m3/s for 2 years and then decreased to 0.7 m3/s in 2014. In 7.3 years, at least 187 × 106 m3 of magma was injected.

Patagonian and Antarctic dust as recorded in the sediments of Laguna Potrok Aike (Patagonia, Argentina)

NASA Astrophysics Data System (ADS)

Haberzettl, Torsten; Stopp, Annemarie; Lisé-Pronovost, Agathe; Gebhardt, Catalina; Ohlendorf, Christian; Zolitschka, Bernd; von Eynatten, Hilmar; Kleinhanns, Ilka; Pasado Science Team

2010-05-01

Although an increasing number of terrestrial paleoclimatic records from southern South America has been published during the last decade, these archives mostly cover the Lateglacial and/or the Holocene. Only little is known about the Patagonian climate before the Last Glacial Maximum. Here, we present a continuous, high-resolution magnetic susceptibility record for the past 48 ka from the maar lake Laguna Potrok Aike (51°58' S, 70°23' W, southern Patagonia, Argentina). Magnetic susceptibility serves as an excellent parameter for the parallelization of sediment cores all over Laguna Potrok Aike including sediment cores taken within the ICDP (International Continental Scientific Drilling Program) project PASADO (Potrok Aike maar lake Sediment Archive Drilling prOject). Additionally, magnetic susceptibility is assumed to be a proxy for dust deposition in this lake. Distinct similarities were found between the independently dated magnetic susceptibility record from Laguna Potrok Aike and the non-sea-salt calcium (nss-Ca) flux from the EPICA Dome C ice core record (75°06'S, 123°24'E) the latter being a proxy for mineral dust deposition in Antarctica [1]. Comparison of the two records and variations in grain size of the Laguna Potrok Aike sediment records indicate a relatively high aeolian activity in southern South America during the glacial period. During the Holocene climatic conditions driving sediment deposition seem to have been more variable and less dominated by wind compared to glacial times. Although the source of the dust found in Antarctic ice cores often has been attributed to Patagonia [2], we present the first evidence for contemporaneity of aeolian deposition in both the target area (Antarctica) and the major source area (Patagonia). Considering the similarities of the two records, magnetic susceptibility might yield the potential for chronological information: transfer of the ice core age model to a lacustrine sediment record. This would be important

Expanding Geophysical and Geochemical Investigation of Causes of Extraordinary Unrest at the Laguna del Maule (Rhyolitic) Volcanic Field, Southern Andes, Chile

NASA Astrophysics Data System (ADS)

Singer, B. S.

2014-12-01

The Laguna del Maule Volcanic Field, Chile, includes an unusually large and recent concentration of silicic eruptions. Since 2007 the crust here has been inflating at an astonishing rate of 25 cm/yr. Findings thus far lead to the hypothesis that the silicic vents have tapped an extensive layer of crystal-poor, rhyolitic melt that began to form atop a magmatic mush zone that was established by ~20 ka with a renewed phase of rhyolite eruptions during the Holocene. Modeling of surface deformation, magnetotelluric data, and gravity changes suggest that magma is currently intruding at a depth of ~5 km. Swarms of volcano-tectonic and long period earthquakes, mostly of M < 2, have occurred beneath the most recent rhyolite coulees on the southwestern and southern margins of the 20 km diameter ring of silicic vents. With support from the US NSF and the Chilean government (SERNAGEOMIN and OVDAS) we are seizing the unique opportunity to investigate, over the next 5 years, the dynamics of this large rhyolitic system while magma migration, reservoir growth, and crustal deformation are actively underway. This collaboration involves scientists and students at: University of Wisconsin-Madison, Georgia Tech, Cornell, University of Alberta, Simon Fraser University, University of Chile-Santiago, CONICET/University of San Juan-Argentina, Nanyang Technological University-Singapore, SERNAGEOMIN, OVDAS, USGS, and SEGEMAR-Argentina. Team members will be introduced in this presentation. Our approach includes augmenting the OVDAS array of 6 permanent seisic stations with 40 additional instruments to conduct tomographic, receiver function and ambient noise studies. We continue to collect 4-D gravity data from 37 stations. Surface deformation is monitored via cGPS at 5 permanent receivers and InSAR data. A magnetotelluric survey across the Andes at 36o S is planned. Geochemical studies include mineral zoning and U-Th disequilibrium of zircons to constrain the timing of magma intrusion and

Ikaite precipitation in a lacustrine environment - implications for palaeoclimatic studies using carbonates from Laguna Potrok Aike (Patagonia, Argentina)

NASA Astrophysics Data System (ADS)

Oehlerich, Markus; Mayr, Christoph; Griesshaber, Erika; Lücke, Andreas; Oeckler, Oliver M.; Ohlendorf, Christian; Schmahl, Wolfgang W.; Zolitschka, Bernd

2013-07-01

The monoclinic mineral ikaite (CaCO3 · 6H2O) and its pseudomorphs are potentially important archives for palaeoenvironmental reconstructions. Natural ikaite occurs in a small temperature range near freezing point and is reported mainly from marine and only rarely from continental aquatic environments. Ikaite transforms to more stable anhydrous forms of CaCO3 after an increase in temperature or when exposed to atmospheric conditions. The knowledge about conditions for natural ikaite formation, its stable isotope fractionation factors and isotopic changes during transformation to calcite is very restricted. Here, for the first time, primary precipitation of idiomorphic ikaite and its calcite pseudomorphs are reported from a subsaline lake, Laguna Potrok Aike, in southern Argentina. The calculated stable oxygen isotope fractionation factor between lake water and ikaite-derived calcite (αPAI = 1.0324 at a temperature of 4.1 °C) is close to but differs from that of primarily inorganically precipitated calcite. Pseudomorphs after ikaite rapidly disintegrate into calcite powder that is indistinguishable from μm-sized calcite crystals in the sediment record of Laguna Potrok Aike suggesting an ikaite origin of sedimentary calcites. Therefore, the Holocene carbonates of Laguna Potrok Aike have the potential to serve as a recorder of past hydrological variation.

Limnology of Laguna Tortuguero, Puerto Rico

USGS Publications Warehouse

Quinones-Marquez, Ferdinand; Fuste, Luis A.

1978-01-01

The principal chemical, physical and biological characteristics, and the hydrology of Laguna Tortuguero, Puerto Rico, were studied from 1974-75. The lagoon, with an area of 2.24 square kilometers and a volume of about 2.68 million cubic meters, contains about 5 percent of seawater. Drainage through a canal on the north side averages 0.64 cubic meters per second per day, flushing the lagoon about 7.5 times per year. Chloride and sodium are the principal ions in the water, ranging from 300 to 700 mg/liter and 150 to 400 mg/liter, respectively. Among the nutrients, nitrogen averages about 1.7 mg/liter, exceeding phosphorus in a weight ratio of 170:1. About 10 percent of the nitrogen and 40 percent of the phosphorus entering the lagoon is retained. The bottom sediments, with a volume of about 4.5 million cubic meters, average 0.8 and 0.014 percent nitrogen and phosphorus, respectively. (Woodard-USGS)

Water quality mapping of Laguna de Bay and its watershed, Philippines

NASA Astrophysics Data System (ADS)

Saito, S.; Nakano, T.; Shin, K.; Maruyama, S.; Miyakawa, C.; Yaota, K.; Kada, R.

2011-12-01

Laguna de Bay (or Laguna Lake) is the largest lake in the Philippines, with a surface area of 900 km2 and its watershed area of 2920 km2 (Santos-Borja, 2005). It is located on the southwest part of the Luzon Island and its watershed contains 5 provinces, 49 municipalities and 12 cities, including parts of Metropolitan Manila. The water quality in Laguna de Bay has significantly deteriorated due to pollution from soil erosion, effluents from chemical industries, and household discharges. In this study, we performed multiple element analysis of water samples in the lake and its watersheds for chemical mapping, which allows us to evaluate the regional distribution of elements including toxic heavy metals such as Cd, Pb and As. We collected water samples from 24 locations in Laguna de Bay and 160 locations from rivers in the watersheds. The sampling sites of river are mainly downstreams around the lake, which covers from urbanized areas to rural areas. We also collected well water samples from 17 locations, spring water samples from 10 locations, and tap water samples from 21 locations in order to compare their data with the river and lake samples and to assess the quality of household use waters. The samples were collected in dry season of the study area (March 13 - 17 and May 2 - 9, 2011). The analysis was performed at the Research Institute for Humanity and Nature (RIHN), Japan. The concentrations of the major components (Cl, NO3, SO4, Ca, Mg, Na, and K) dissolved in the samples were determined with ion chromatograph (Dionex Corporation ICS-3000). We also analyzed major and trace elements (Li, B, Na, Mg, Al, Si, P, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn Ga, Ge, As, Se, Rb, Sr, Y, Zr, Mo, Ag, Cd, Sn, Sb, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, W, Pb and U) with inductively coupled plasma-mass spectrometry (ICP-MS, Agilent Technologies 7500cx). The element concentrations of rivers are characterized by remarkable regional variations. For

Condensate polisher prefiltration study for Laguna Verde Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia, A.; Oyen, L.C.; Nelson, R.A.

1995-05-01

This paper describes an analysis of the iron and copper in the condensate and the technical and economic assessment of the installation of condensate polisher prefilters in Comision Federal de Electricidad`s Laguna Verde Nuclear Generating Station (LVNGS) north of Veracruz, Mexico. LVNGS is a 654 MWe General Electric BWR plant; Unit 1 has been in commercial operation since July, 1990, and Unit 2 is scheduled to become operational in June, 1995. The primary purpose of this study was to (1) analyze the high iron and copper concentrations in the condensate and feedwater, (2) identify, assess, and evaluate techniques to reducemore » the iron and copper concentrations, and (3) perform a cost-benefit analysis of the installation of implementing the appropriate techniques.« less

Level-2 IPE for the Laguna Verde NPS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arellano, J.; De Loera, M.A.; Rea, R.

1996-12-31

In response to generic letter GL 88-20, Comision Federal de Electricidad and Instituto de Investigaciones Electricas have jointly developed the individual plant examination (IPE) for the Laguna Verde nuclear power station unit I (LVNPS). This plant is a 675-MW(electric) boiling water reactor (BWR/5) with a reinforced concrete Mark-II containment. The approach used to fulfill the IPE requirements was to make a level-1 probabilistic risk assessment (IPE level 1) plus a containment performance analysis including the behavior and release of the fission products to the environment (IPE level 2). This paper describes the level-2 portion of the LVNPS IPE, paying specialmore » attention to both some improvements to the traditional analytical methods and to the main results.« less

Water-quality reconnaissance of Laguna Tortuguero, Vega Baja, Puerto Rico, March 1999-May 2000

USGS Publications Warehouse

Soler-Lopez, Luis; Guzman-Rios, Senen; Conde-Costas, Carlos

2006-01-01

The Laguna Tortuguero, a slightly saline to freshwater lagoon in north-central Puerto Rico, has a surface area of about 220 hectares and a mean depth of about 1.2 meters. As part of a water-quality reconnaissance, water samples were collected at about monthly and near bi-monthly intervals from March 1999 to May 2000 at four sites: three stations inside the lagoon and one station at the artificial outlet channel dredged in 1940, which connects the lagoon with the Atlantic Ocean. Physical characteristics that were determined from these water samples were pH, temperature, specific conductance, dissolved oxygen, dissolved oxygen saturation, and discharge at the outlet canal. Other water-quality constituents also were determined, including nitrogen and phosphorus species, organic carbon, chlorophyll a and b, plankton biomass, hardness, alkalinity as calcium carbonate, and major ions. Additionally, a diel study was conducted at three stations in the lagoon to obtain data on the diurnal variation of temperature, specific conductance, dissolved oxygen, and dissolved oxygen saturation. The data analysis indicates the water quality of Laguna Tortuguero complies with the Puerto Rico Environmental Quality Board standards and regulations.

Identifying wells downstream from Laguna Dam that yield water that will be replaced by water from the Colorado River, Arizona and California

USGS Publications Warehouse

Owen-Joyce, Sandra J.

2000-01-01

This report summarizes a comprehensive study and development of the method documented in Owen-Joyce and others (2000). That report and one for the area upstream from Laguna Dam (Wilson and Owen-Joyce, 1994) document the accounting-surface method to identify wells that yield water that will be replaced by water from the Colorado River. Downstream from Laguna Dam, the Colorado River is the source for nearly all recharge to the river aquifer. The complex surface-water and ground-water system that exists in the area is, in part, the result of more than 100 years of water-resources development. Agriculture is the principal economy and is possible only with irrigation. The construction and operation of canals provides the means to divert and distribute Colorado River water to irrigate agricultural lands on the flood plains and mesas along the Colorado and Gila Rivers, in Imperial and Coachella Valleys, and in the area upstream from Dome along the Gila River. Water is withdrawn from wells for irrigation, dewatering, and domestic use. The area downstream from Laguna Dam borders additional areas of agricultural development in Mexico where Colorado River water also is diverted for irrigation.

Limnology in El Dorado: some surprising aspects of the regulation of phytoplankton productive capacity in a high-altitude Andean lake (Laguna de Guatavita, Colombia).

PubMed

Donato, Jhon; Jimenez, Paola; Reynolds, Colin

2012-09-01

High-altitude mountain lakes remain understudied, mostly because of their relative inaccessibility. Laguna de Guatavita, a small, equatorial, high-altitude crater lake in the Eastern Range of the Colombian Andes, was once of high cultural importance to pre-Columban inhabitants, the original location of the legendary El Dorado. We investigated the factors regulating the primary production in Laguna de Guatavita (4degrees58'50" N - 73degrees46'43" W, alt. 2 935m.a.s.l., area: 0.11km2, maximum depth: 30m), during a series of three intensive field campaigns, which were conducted over a year-long period in 2003-2004. In each, standard profiles of temperature, oxygen concentration and light intensity were determined on each of 16-18 consecutive days. Samples were collected and analysed for chlorophyll and for biologically-significant solutes in GF/F-filtered water (NH4+, NO3(-), NO2(-); soluble reactive phosphorus). Primary production was also determined, by oxygen generation, on each day of the campaign. Our results showed that the productive potential of the lake was typically modest (campaign averages of 45-90mg C/m2.h) but that many of the regulating factors were not those anticipated intuitively. The lake is demonstrably meromictic, reminiscent ofkarstic dolines in higher latitudes, its stratification being maintained by solute- concentration gradients. Light penetration is poor, attributable to the turbidity owing to fine calcite and other particulates in suspension. Net primary production in the mixolimnion of Laguna de Guavita is sensitive to day-to-day variations in solar irradiance at the surface. However, deficiencies in nutrient availability, especially nitrogen, also constrain the capacity of the lake to support a phytoplankton. We deduced that Laguna de Guatavita is something of a limnological enigma, atypical of the common anticipation of a "mountain lake". While doubtlessly not unique, comparable descriptions of similar sites elsewhere are sufficiently

Identification and dating of indigenous water storage reservoirs along the Rio San José at Laguna Pueblo, western New Mexico, USA

USGS Publications Warehouse

Huckleberry, Gary; Ferguson, T.J.; Rittenour, Tammy M.; Banet, Chris; Mahan, Shannon

2016-01-01

An investigation into indigenous water storage on the Rio San José in western New Mexico was conducted in support of efforts by the Pueblo of Laguna to adjudicate their water rights. Here we focus on stratigraphy and geochronology of two Native American-constructed reservoirs. One reservoir located near the community of Casa Blanca was formed by a ∼600 m (2000 feet) long stone masonry dam that impounded ∼1.6 × 106 m3 (∼1300 acre-feet) of stored water. Four optically stimulated luminescence (OSL) ages obtained on reservoir deposits indicate that the dam was constructed prior to AD 1825. The other reservoir is located adjacent to Old Laguna Pueblo and contains only a small remnant of its former earthen dam. The depth and distribution of reservoir deposits and a photogrammetric analyses of relict shorelines indicate a storage capacity of ∼6.5 × 106 m3 (∼5300 ac-ft). OSL ages from above and below the base of the reservoir indicate that the reservoir was constructed sometime after AD 1370 but before AD 1750. The results of our investigation are consistent with Laguna oral history and Spanish accounts demonstrating indigenous construction of significant water-storage reservoirs on the Rio San José prior to the late nineteenth century.

A 20,000-year record of environmental change from Laguna Kollpa Kkota, Bolivia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seltzer, G.O.; Abbott, M.B.

Most records of paleoclimate in the Bolivian Andes date from the last glacial-to-interglacial transition. However, Laguna Kollpa Kkota and other lakes like it, formed more than 20,000 yr BP when glaciers retreated and moraines dammed the drainage of the valleys they are located in. These lakes were protected from subsequent periods of glaciation because the headwalls of these valleys are below the level of the late-Pleistocene glacial equilibrium-line altitude. The chemical, mineral, and microfossil stratigraphies of these glacial lakes provide continuous records of environmental change for the last 20,000 years that can be used to address several problems in paleoclimatemore » specific to tropical-subtropical latitudes. Preliminary results from Laguna Kollpa Kkota indicate that glacial equilibrium-line altitudes were never depressed more than 600 m during the last 20,000 years, suggesting that temperatures were reduced only a few-degrees celsius over this time period. Sedimentation rates and the organic carbon stratigraphy of cores reflect an increase in moisture in the late Pleistocene just prior to the transition to a warmer and drier Holocene. The pollen and diatom concentrations in the sediments are sufficient to permit the high resolution analyses needed to address whether or not there were climatic reversals during the glacial-to-interglacial transition.« less

Chemistry of Hot Spring Pool Waters in Calamba and Los Banos and Potential Effect on the Water Quality of Laguna De Bay

NASA Astrophysics Data System (ADS)

Balangue, M. I. R. D.; Pena, M. A. Z.; Siringan, F. P.; Jago-on, K. A. B.; Lloren, R. B.; Taniguchi, M.

2014-12-01

Since the Spanish Period (1600s), natural hot spring waters have been harnessed for balneological purposes in the municipalities of Calamba and Los Banos, Laguna, south of Metro Manila. There are at more than a hundred hot spring resorts in Brgy. Pansol, Calamba and Tadlac, Los Banos. These two areas are found at the northern flanks of Mt. Makiling facing Laguna de Bay. This study aims to provide some insights on the physical and chemical characteristics of hot spring resorts and the possible impact on the lake water quality resulting from the disposal of used water. Initial ocular survey of the resorts showed that temperature of the pool water ranges from ambient (>300C) to as high as 500C with an average pool size of 80m3. Water samples were collected from a natural hot spring and pumped well in Los Banos and another pumped well in Pansol to determine the chemistry. The field pH ranges from 6.65 to 6.87 (Pansol springs). Cation analysis revealed that the thermal waters belonged to the Na-K-Cl-HCO3 type with some trace amount of heavy metals. Methods for waste water disposal are either by direct discharge down the drain of the pool or by discharge in the public road canal. Both methods will dump the waste water directly into Laguna de Bay. Taking in consideration the large volume of waste water used especially during the peak season, the effect on the lake water quality would be significant. It is therefore imperative for the environmental authorities in Laguna to regulate and monitor the chemistry of discharges from the pool to protect both the lake water as well as groundwater quality.

Trace metal partitioning in Thalassia testudinum and sediments in the Lower Laguna Madre, Texas.

PubMed

Whelan, Thomas; Espinoza, Jorge; Villarreal, Xiomara; Cottagoma, Maria

2005-01-01

Seagrass communities dominate the Laguna Madre, which accounts for 25% of the coastal region of Texas. Seagrasses are essential to the health of the Laguna Madre (LM) and have experienced an overall decline in coverage in the Lower Laguna Madre (LLM) since 1967. Little is known on the existing environmental status of the LLM. This study focuses on the trace metal chemistry of four micronutrient metals, Fe, Mn, Cu, and Zn, and two non-essential metals, Pb and As, in the globally important seagrass Thalassia testudinum. Seasonal trends show that concentrations of most essential trace metals increase in the tissue during the summer months. With the exception of (1) Cu in the vertical shoot and root, and (2) Mn in the roots, no significant positive correlation exists between the rhizosphere sediment and T. testudinum tissue. Iron indicates a negative correlation between the morphological units and the rhizosphere sediments. No other significant relationship was found between the sediments and the T. testudinum tissue. Mn was enriched up to 10-fold in the leaf tissue relative to the other morphological units and also enriched relative to the rhizosphere sediments. Both Cu and Mn appear to be enriched in leaf tissue compared to other morphological units and also enriched relative to the Cu and Mn in the rhizoshpere sediments. Sediments cores taken in barren areas were slightly elevated in Zn relative to the rhizosphere sediments, whereas no other metals showed statistical differences between barren sediment cores and rhizosphere sediments. However, no correlation was measured in T. testudinum tissue and Zn in rhizosphere sediments. Previous studies suggested that Fe/Mn ratios could indicate differences between seagrass environments. Our results indicate that there is an influence from the Rio Grande in the Fe/Mn signature in sediments, and that ratio is not reflected in the T. testudinum tissue. The results from this study show that the LLM contains trace metal

Field reconnaissance of the effects of the earthquake of April 13, 1973, near Laguna de Arenal, Costa Rica

USGS Publications Warehouse

Plafker, George

1973-01-01

At about 3:34 a.m. on April 13, 1973, a moderate-sized, but widely-felt, earthquake caused extensive damage with loss of 23 lives in a rural area of about 150 km2 centered just south of Laguna de Arenal in northwestern Costa Rica (fig. 1). This report summarizes the results of the writer's reconnaissance investigation of the area that was affected by the earthquake of April 13, 1973. A 4-day field study of the meizoseismal area was carried out during the period from April 28 through May 1 under the auspices of the U.S. Geological Survey. The primary objective of this study was to evaluate geologic factors that contributed to the damage and loss of life. The earthquake was also of special interest because of the possibility that it was accompanied by surface faulting comparable to that which occurred at Managua, Nicaragua, during the disastrous earthquake of December 23, 1972 (Brown, Ward, and Plafker, 1973). Such earthquake-related surface faulting can provide scientifically valuable information on active tectonic processes at shallow depths within the Middle America arc. Also, identification of active faults in this area is of considerable practical importance because of the planned construction of a major hydroelectrical facility within the meizoseismal area by the Instituto Costarricense de Electricidad (I.C.E.). The project would involve creation of a storage reservoir within the Laguna de Arenal basin and part of the Río Arenal valley with a 75 m-high earthfill dam across Río Arenal at a point about 10 km east of the outlet of Laguna de Arenal.

Carbonate Formation And Diagenesis In Pastos Grandes Laguna (Bolivia): Modern Analog For The South Atlantic Cretaceous Presalt Travertinoid Deposits

NASA Astrophysics Data System (ADS)

Muller, E.; Ader, M.; Gérard, E.; Virgone, A.; Gaucher, E.; Bougeault, C.; Durlet, C.; Moreira, M. A.; Virgile, R.; Vennin, E.; Agogué, H.; Hugoni, M.

2017-12-01

The Cretaceous Presalt travertinoid deposits of the South Atlantic are usually considered as "strange deposits" having poor equivalents in modern environments. Pastos Grandes Laguna, which is located in a 2.9 Ma caldera on the andean-bolivian Altiplano (at 4450 m), is intersected by active faults with hydrothermal fluids and presents a spherulitic plateform with similar sedimentological facies to the Presalt: halite and bedded evaporites, shrub-shaped calcites, ooids, pisolites and various stromatolites. Pastos Grandes Laguna is certainly one of the best modern analog of the Presalt for investigating the on going processes of carbonate deposition and diagenesis and the influence of biology. During two expeditions, we recovered samples of gas, water and microbial mats from the hydrothermal sources to the evaporating zones on the spherulitic plateform. These samples are being analyzed to determine 1) the influence of the gases emitted at the hydrothermal sources (chemical and isotopic composition) on the chemistry of the Laguna and the mineralogy of its sediments and 2) the role of ecosystems that develop in this environment on carbonate formation. Preliminary results on gas composition, corrected for the atmospheric contribution, indicates a magmatic source of CO2 partly mantellic associated with a small crustal contribution. Other initial results have so far indicated that CO2 gas emissions, evaporation, as well as photosynthesis and respiration play a role on water chemistry and carbonate precipitation. This study will contribute to the overall understanding of the role of organisms in sedimentation and the predictive diagenetic evolution of hydrothermal and lacustrine deposits.

Carbon and nitrogen isotope composition of core catcher samples from the ICDP deep drilling at Laguna Potrok Aike (Patagonia, Argentina)

NASA Astrophysics Data System (ADS)

Luecke, Andreas; Wissel, Holger; Mayr*, Christoph; Oehlerich, Markus; Ohlendorf, Christian; Zolitschka, Bernd; Pasado Science Team

2010-05-01

The ICDP project PASADO aims to develop a detailed paleoclimatic record for the southern part of the South American continent from sediments of Laguna Potrok Aike (51°58'S, 70°23'W), situated in the Patagonian steppe east of the Andean cordillera and north of the Street of Magellan. The precursor project SALSA recovered the Holocene and Late Glacial sediment infill of Laguna Potrok Aike and developed the environmental history of the semi-arid Patagonian steppe by a consequent interdisciplinary multi-proxy approach (e.g. Haberzettl et al., 2007). From September to November 2008 the ICDP deep drilling took place and successfully recovered in total 510 m of sediments from two sites resulting in a composite depth of 106 m for the selected main study Site 2. A preliminary age model places the record within the last 50.000 years. During the drilling campaign, the core catcher content of each drilled core run (3 m) was taken as separate sample to be shared and distributed between involved laboratories long before the main sampling party. A total of 70 core catcher samples describe the sediments of Site 2 and will form the base for more detailed investigations on the palaeoclimatic history of Patagonia. We here report on the organic carbon and nitrogen isotope composition of bulk sediment and plant debris of the core catcher samples. Similar investigations were performed for Holocene and Late Glacial sediments of Laguna Potrok Aike revealing insights into the organic matter dynamics of the lake and its catchment as well as into climatically induced hydrological variations with related lake level fluctuations (Mayr et al., 2009). The carbon and nitrogen content of the core catcher fine sediment fraction (<200 µm) is low to very low (around 1 % and 0.1 %, respectively) and requires particular attention in isotope analysis. The carbon isotope composition shows comparably little variation around a value of -26.0 per mil. The positive values of the Holocene and the Late

Salt lake Laguna de Fuente de Piedra (S-Spain) as Late Quaternary palaeoenvironmental archive

NASA Astrophysics Data System (ADS)

Höbig, Nicole; Melles, Martin; Reicherter, Klaus

2014-05-01

This study deals with Late Quaternary palaeoenvironmental variability in Iberia reconstructed from terrestrial archives. In southern Iberia, endorheic basins of the Betic Cordilleras are relatively common and contain salt or fresh-water lakes due to subsurface dissolution of Triassic evaporites. Such precipitation or ground-water fed lakes (called Lagunas in Spanish) are vulnerable to changes in hydrology, climate or anthropogenic modifications. The largest Spanish salt lake, Laguna de Fuente de Piedra (Antequera region, S-Spain), has been investigated and serves as a palaeoenvironmental archive for the Late Pleistocene to Holocene time interval. Several sediment cores taken during drilling campaigns in 2012 and 2013 have revealed sedimentary sequences (up to 14 m length) along the shoreline. A multi-proxy study, including sedimentology, geochemistry and physical properties (magnetic susceptibility) has been performed on the cores. The sedimentary history is highly variable: several decimetre thick silty variegated clay deposits, laminated evaporites, and even few-centimetre thick massive gypsum crystals (i.e., selenites). XRF analysis was focussed on valuable palaeoclimatic proxies (e.g., S, Zr, Ti, and element ratios) to identify the composition and provenance of the sediments and to delineate palaeoenvironmental conditions. First age control has been realized by AMS-radiocarbon dating. The records start with approximately 2-3 m Holocene deposits and reach back to the middle of MIS 3 (GS-3). The sequences contain changes in sedimentation rates as well as colour changes, which can be summarized as brownish-beige deposits at the top and more greenish-grey deposits below as well as highly variegated lamination and selenites below ca. 6 m depth. The Younger Dryas, Bølling/Allerød, and the so-called Mystery Interval/Last Glacial Maximum have presumably been identified in the sediment cores and aligned to other climate records. In general, the cores of the Laguna de

Congener-specific polychlorinated biphenyl patterns in eggs of aquatic birds from the lower Laguna Madre, Texas

USGS Publications Warehouse

Mora, Miguel A.

1996-01-01

Eggs from four aquatic bird species nesting in the Lower Laguna Madre, Texas, were collected to determine differences and similarities in the accumulation of congener-specific polychlorinated biphenyls (PCBs) and to evaluate PCB impacts on reproduction. Because of the different toxicities of PCB congeners, it is important to know which congeners contribute most to total PCBs. The predominant PCB congeners were 153, 138, 180, 110, 118, 187, and 92. Collectively, congeners 153, 138, and 180 accounted for 26 to 42% of total PCBs. Congener 153 was the most abundant in Caspian terns (Sterna caspia) and great blue herons (Ardea herodias) and congener 138 was the most abundant in snowy egrets (Egretta thula) and tricolored herons (Egretta tricolor). Principal component analysis indicated a predominance of higher chlorinated biphenyls in Caspian terns and great blue herons and lower chlorinated biphenyls in tricolored herons. Snowy egrets had a predominance of pentachlorobiphenyls. These results suggest that there are differences in PCB congener patterns in closely related species and that these differences are more likely associated with the species' diet rather than metabolism. Total PCBs were significantly greater (p < 0.05) in Caspian terns than in the other species. Overall, PCBs in eggs of birds from the Lower Laguna Madre were below concentrations known to affect bird reproduction.

Postglacial history of alpine vegetation, fire, and climate from Laguna de Río Seco, Sierra Nevada, southern Spain

NASA Astrophysics Data System (ADS)

Anderson, R. S.; Jiménez-Moreno, G.; Carrión, J. S.; Pérez-Martínez, C.

2011-06-01

The Sierra Nevada of southern Spain is a landscape with a rich biological and cultural heritage. The range was extensively glaciated during the late Pleistocene. However, the postglacial paleoecologic history of the highest range in southern Europe is nearly completely unknown. Here we use sediments from a small lake above present treeline - Laguna de Río Seco at 3020 m elevation - in a paleoecological study documenting over 11,500 calendar years of vegetation, fire and climate change, addressing ecological and paleoclimatic issues unique to this area through comparison with regional paleoecological sequences. The early record is dominated by Pinus pollen, with Betula, deciduous Quercus, and grasses, with an understory of shrubs. It is unlikely that pine trees grew around the lake, and fire was relatively unimportant at this site during this period. Aquatic microfossils indicate that the wettest conditions and highest lake levels at Laguna de Río Seco occurred before 7800 cal yr BP. This is in contrast to lower elevation sites, where wettest conditions occurred after ca 7800. Greater differences in early Holocene seasonal insolation may have translated to greater snowpack and subsequently higher lake levels at higher elevations, but not necessarily at lower elevations, where higher evaporation rates prevailed. With declining seasonality after ca 8000 cal yr BP, but continuing summer precipitation, lake levels at the highest elevation site remained high, but lake levels at lower elevation sites increased as evaporation rates declined. Drier conditions commenced regionally after ca 5700 cal yr BP, shown at Laguna de Río Seco by declines in wetland pollen, and increases in high elevation steppe shrubs common today ( Juniperus, Artemisia, and others). The disappearance or decline of mesophytes, such as Betula from ca 4000 cal yr BP is part of a regional depletion in Mediterranean Spain and elsewhere in Europe from the mid to late Holocene. On the other hand

Groundwater flow in a closed basin with a saline shallow lake in a volcanic area: Laguna Tuyajto, northern Chilean Altiplano of the Andes.

PubMed

Herrera, Christian; Custodio, Emilio; Chong, Guillermo; Lambán, Luis Javier; Riquelme, Rodrigo; Wilke, Hans; Jódar, Jorge; Urrutia, Javier; Urqueta, Harry; Sarmiento, Alvaro; Gamboa, Carolina; Lictevout, Elisabeth

2016-01-15

Laguna Tuyajto is a small, shallow saline water lake in the Andean Altiplano of northern Chile. In the eastern side it is fed by springs that discharge groundwater of the nearby volcanic aquifers. The area is arid: rainfall does not exceed 200mm/year in the rainiest parts. The stable isotopic content of spring water shows that the recharge is originated mainly from winter rain, snow melt, and to a lesser extent from some short and intense sporadic rainfall events. Most of the spring water outflowing in the northern side of Laguna Tuyajto is recharged in the Tuyajto volcano. Most of the spring water in the eastern side and groundwater are recharged at higher elevations, in the rims of the nearby endorheic basins of Pampa Colorada and Pampa Las Tecas to the East. The presence of tritium in some deep wells in Pampa Colorada and Pampa Las Tecas indicates recent recharge. Gas emission in recent volcanoes increase the sulfate content of atmospheric deposition and this is reflected in local groundwater. The chemical composition and concentration of spring waters are the result of meteoric water evapo-concentration, water-rock interaction, and mainly the dissolution of old and buried evaporitic deposits. Groundwater flow is mostly shallow due to a low permeability ignimbrite layer of regional extent, which also hinders brine spreading below and around the lake. High deep temperatures near the recent Tuyajto volcano explain the high dissolved silica contents and the δ(18)O shift to heavier values found in some of the spring waters. Laguna Tuyajto is a terminal lake where salts cumulate, mostly halite, but some brine transfer to the Salar de Aguas Calientes-3 cannot be excluded. The hydrogeological behavior of Laguna Tuyajto constitutes a model to understand the functioning of many other similar basins in other areas in the Andean Altiplano. Copyright © 2015 Elsevier B.V. All rights reserved.

Laguna Madre Water Purification using Biochar from Citrus Peels

NASA Astrophysics Data System (ADS)

Lopez, C.; Al-Qudah, O. M.

2017-12-01

Laguna Madre is an important lagoon in the coast of Texas. It is one of the seven hypersaline lagoons in the world. Due to inflow of water with extreme amounts of phosphorus and nitrates and the low inflow of freshwater, the lagoon has high amount of phosphorus and nitrates which can be harmful for fish and plants situated in the lagoon. The goal is to be able to perform a filtration method with citrus peels biochar, and then to evaluate and compare the produced biochar, zeolite, and activated carbon as an infiltration filter by assessing reductions of nitrogen and phosphorus compounds, as well as sum selected trace elements. Furthermore, the current research will investigate how long the cleaning capacity of biochar lasts and how the performance of the filter changes under an increased load of contaminants. The performance of biochar from different parent materials and recycling options for the used filter materials are also included in this research.

Selected Hydrologic, Water-Quality, Biological, and Sedimentation Characteristics of Laguna Grande, Fajardo, Puerto Rico, March 2007-February 2009

USGS Publications Warehouse

Soler-López, Luis R.; Santos, Carlos R.

2010-01-01

Laguna Grande is a 50-hectare lagoon in the municipio of Fajardo, located in the northeasternmost part of Puerto Rico. Hydrologic, water-quality, and biological data were collected in the lagoon between March 2007 and February 2009 to establish baseline conditions and determine the health of Laguna Grande on the basis of preestablished standards. In addition, a core of bottom material was obtained at one site within the lagoon to establish sediment depositional rates. Water-quality properties measured onsite (temperature, pH, dissolved oxygen, specific conductance, and water transparency) varied temporally rather than areally. All physical properties were in compliance with current regulatory standards established for Puerto Rico. Nutrient concentrations were very low and in compliance with current regulatory standards (less than 5.0 and 1.0 milligrams per liter for total nitrogen and total phosphorus, respectively). The average total nitrogen concentration was 0.28 milligram per liter, and the average total phosphorus concentration was 0.02 milligram per liter. Chlorophyll a was the predominant form of photosynthetic pigment in the water. The average chlorophyll-a concentration was 6.2 micrograms per liter. Bottom sediment accumulation rates were determined in sediment cores by modeling the downcore activities of lead-210 and cesium-137. Results indicated a sediment depositional rate of about 0.44 centimeter per year. At this rate of sediment accretion, the lagoon may become a marshland in about 700 to 900 years. About 86 percent of the community primary productivity in Laguna Grande was generated by periphyton, primarily algal mats and seagrasses, and the remaining 14 percent was generated by phytoplankton in the water column. Based on the diel studies the total average net community productivity equaled 5.7 grams of oxygen per cubic meter per day (2.1 grams of carbon per cubic meter per day). Most of this productivity was ascribed to periphyton and macrophytes

Looking for Biosignatures in Carbonate Microbialites from the Laguna Negra, Argentinian Andes

NASA Astrophysics Data System (ADS)

Boidi, F. J.; Gomez, F. J.; Fike, D. A.; Bradley, A. S.; Farías, M. E.; Beeler, S.

2015-12-01

The distinction between biotic and abiotic control on microbialites formation and its signatures is relevant since stromatolites are considered the oldest evidence for life on Earth and a target for astrobiological research. The Laguna Negra is a shallow hypersaline lake placed at the Andes, Northwest Argentina, where carbonate microbialites and microbial mats develop. It is a unique system where microbial influence on carbonate precipitation and potential preserved biosignatures in the microbialites can be studied. Here we compare three distinct microbialites systems: carbonate laminar crusts with no visible microbial mats, stromatolites and dm-size oncoids, both related with different microbial mats. Our goal is to unravel the biotic controls on their formation, and the biosignatures there recorded. Laminar crusts are composed of stacked regular and isopachous carbonate lamina. Oncoids laminae are typically characterized by irregular hybrid micro-textures, composed of alternating micritic and botryoidal laminae, and the stromatolites are mostly composed by irregular micritic laminae. Sulfur isotopes of carbonate associated sulphate show similar values but they show differences in the pyrite sulfur isotopes suggesting differences in the fractionation degree, possibly related to sulphate reducing bacteria and variable sulphate reservoirs in the case of stromatolites and oncoids. δ13C fractionation between organic carbon and carbonates suggests photosynthesis, but other metabolisms cannot yet be discarded. 16S rDNA data of the microbial communities associated with the carbonate structures indicate the presence of these taxonomic groups and those that are known to influence carbonate precipitation, particularly in the stromatolites associated microbial community. Our data indicate significant differences between the three systems in terms of stable isotopes, textures and associated microbial diversity, suggesting a microbial control on stromatolites and oncoids

Rapid uplift in Laguna del Maule volcanic field of the Andean Southern Volcanic Zone (Chile) measured by satellite radar interferometry

NASA Astrophysics Data System (ADS)

Feigl, K.; Ali, T.; Singer, B. S.; Pesicek, J. D.; Thurber, C. H.; Jicha, B. R.; Lara, L. E.; Hildreth, E. W.; Fierstein, J.; Williams-Jones, G.; Unsworth, M. J.; Keranen, K. M.

2011-12-01

The Laguna del Maule (LdM) volcanic field of the Andean Southern Volcanic Zone extends over 500 square kilometers and comprises more than 130 individual vents. As described by Hildreth et al. (2010), the history has been defined from sixty-eight Ar/Ar and K-Ar dates. Silicic eruptions have occurred throughout the past 3.7 Ma, including welded ignimbrite associated with caldera formation at 950 ka, small rhyolitic eruptions between 336 and 38 ka, and a culminating ring of 36 post-glacial rhyodacite and rhyolite coulees and domes that encircle the lake. Dating of five post-glacial flows implies that these silicic eruptions occurred within the last 25 kyr. Field relations indicate that initial eruptions comprised modest volumes of mafic rhyodacite magma that were followed by larger volumes of high silica rhyolite. The post-glacial flare-up of silicic magmatism from vents distributed around the lake, is unprecedented in the history of this volcanic field. Using satellite radar interferometry (InSAR), Fournier et al. (2010) measured uplift at a rate of more than 180 mm/year between 2007 and 2008 in a round pattern centered on the west side of LdM. More recent InSAR observations suggest that rapid uplift has continued from 2008 through early 2011. In contrast, Fournier et al. found no measurable deformation in an interferogram spanning 2003 through 2004. In this study, we model the deformation field using the General Inversion of Phase Technique (GIPhT), as described by Feigl and Thurber (2009). Two different models fit the data. The first model assumes a sill at ~5 km depth has been inflating at a rate of more than 20 million cubic meters per year since 2007. The second model assumes that the water level in the lake dropped at a rate of 20 m/yr from January 2007 through February 2010, thus reducing the load on an elastic simulation of the crust. The rate of intrusion inferred from InSAR is an order of magnitude higher than the average rate derived from well-dated arc

A comprehensive analysis of the performance characteristics of the Mount Laguna solar photovoltaic installation

NASA Technical Reports Server (NTRS)

Shumka, A.; Sollock, S. G.

1981-01-01

This paper represents the first comprehensive survey of the Mount Laguna Photovoltaic Installation. The novel techniques used for performing the field tests have been effective in locating and characterizing defective modules. A comparative analysis on the two types of modules used in the array indicates that they have significantly different failure rates, different distributions in degradational space and very different failure modes. A life cycle model is presented to explain a multimodal distribution observed for one module type. A statistical model is constructed and it is shown to be in good agreement with the field data.

Secondary forest succession and tree planting at the Laguna Cartagena and Cabo Rojo wildlife refuges in southwestern Puerto Rico

Treesearch

P.L. Weaver; J.J. Schwagerl

2008-01-01

Secondary forest succession and tree planting are contributing to the recovery of the Cabo Rojo refuge (Headquarters and Salinas tracts) and Laguna Cartagena refuge (Lagoon and Tinaja tracts) of the Fish and Wildlife Service in southwestern Puerto Rico. About 80 species, mainly natives, have been planted on 44 ha during the past 25 y in an effort to reduce the threat...

A High-Resolution Reconstruction of Late Holocene Environmental Change from Laguna Ek'Naab, Northern Holmul Region, Peten, Guatemala

NASA Astrophysics Data System (ADS)

Anderson, L.; Wahl, D.; Estrada-Belli, F.

2015-12-01

Widespread demographic shifts in the southern Maya lowlands at the end of the Classic period have been attributed to environmental change caused by human activity and/or climate variability. Fire was essential to landscape modification and was a primary agent of environmental change associated with prehispanic land use. While several studies have provided insight into the dynamic relationship between natural and anthropogenic drivers of change, defining the specific interplay between natural environmental change, human modification of the environment, and cultural response to changes remains a persistent challenge. Here we present the results of a multi-proxy study that reconstructs fire history, agricultural land use, and environmental change during and after Pre-Columbian Maya settlement. Results are interpreted in the context of settlement history as inferred from archaeological mapping around the study site. Our findings suggest landscape disturbance, as indicated by erosion, local burning, and nearby maize agriculture, was at its peak during the Early Classic period. This disturbance was likely due to large-scale settlement at the nearby site of Witzna'. All proxies indicate a slow decline in disturbance into the Late Classic period, beginning around 1300 cal yr BP. Cival and Chanchich, two proximal site centers to the south of Laguna Ek'Naab, supported their largest populations during the Late Preclassic and Late Classic, with little or no settlement during the Early Classic. The data from Laguna Ek'Naab suggests that Witzna' may have been an important center during the Early Classic. Whether the decreasing environmental degradation after 1240 cal yr BP is do to a decline in local population or changing land use strategies is not discernable based on the data thus far. However, the near complete absence of burning and continued decrease in erosion from 1240-1090 cal yr BP suggests little anthropogenic activity in the area. Burning resumes in the watershed

Distribution and community structure of ichthyoplankton in Laguna Madre seagrass meadows: Potential impact of seagrass species change

USGS Publications Warehouse

Tolan, J.M.; Holt, S.A.; Onuf, C.P.

1997-01-01

Seasonal ichthyoplankton surveys were made in the lower Laguna Madre, Texas, to compare the relative utilization of various nursery habitats (shoal grass, Halodule wrightii; manatee grass, Syringodium filiforme;, and unvegetated sand bottom) for both estuarine and offshore-spawned larvae. The species composition and abundance of fish larvae were determined for each habitat type at six locations in the bay. Pushnet ichthyoplankton sampling resulted in 296 total collections, yielding 107,463 fishes representing 55 species in 24 families. A broad spectrum of both the biotic and physical habitat parameters were examined to link the dispersion and distribution of both pre-settlement and post-settlement larvae to the utilization of shallow seagrass habitats. Sample sites were grouped by cluster analysis (Ward's minimum variance method) according to the similarity of their fish assemblages and subsequently examined with a multiple discriminant function analysis to identify important environmental variables. Abiotic environmental factors were most influential in defining groups for samples dominated by early larvae, whereas measures of seagrass complexity defined groups dominated by older larvae and juveniles. Juvenile-stage individuals showed clear habitat preference, with the more shallow Halodule wrightii being the habitat of choice, whereas early larvae of most species were widely distributed over all habitats. As a result of the recent shift of dominance from Halodule wrightii to Syringodium filiforme, overall reductions in the quality of nursery habitat for fishes in the lower Laguna Madre are projected.

Niebla ceruchis from Laguna Figueroa: dimorphic spore morphology and secondary compounds localized in pycnidia and apothecia

NASA Technical Reports Server (NTRS)

Enzien, M.; Margulis, L.

1988-01-01

During and after the floods of 1979-80 Niebla ceruchis growing epiphytically on Lycium brevipes was one of the dominant aspects of the vegetation in the coastal dunal complex bordering the microbial mats at Laguna Figueroa, Baja California Norte, Mexico. The lichen on denuded branches of Lycium was far more extensively distributed than Lycium lacking lichen. Unusual traits of this Niebla ceruchis strain, namely localization of lichen compounds in the mycobiont reproductive structures (pycnidia and apothecia) and simultaneous presence of bilocular and quadrilocular ascospores, are reported. The abundance of this coastal lichen cover at the microbial mat site has persisted through April 1988.

Characterizing the impacts of the 2006 New Year's flood in the Laguna de Santa Rosa floodplain, Sonoma County, CA

NASA Astrophysics Data System (ADS)

Flint, L. E.; Curtis, J. A.; Flint, A. L.

2006-12-01

The Laguna de Santa Rosa (Laguna), the largest tributary to the Russian River located in Sonoma County, California, occupies a relatively flat low-lying area west of the Santa Rosa Plain. From December 12, 2005 to January 6, 2006 the Laguna experienced heavy flooding, with peak flows on New Year's Day of over 185 m3/s, at a location that experiences median flows of less than 14 m3/s. The objectives of this study were to (1) analyze precipitation intensities and amounts for the region to establish the conditions under which flooding occurred, (2) measure and map inundation areas and floodplain sediment deposition, and (3) compare field data with a GIS sediment deposition potential map. Spatial variations in intensities and total volumes of precipitation correlate well with evidence of local flooding throughout the region, particularly in the mountains to the east and southeast of Santa Rosa. Total precipitation for the month of December was 200 percent of normal, and maximum hourly intensities reached 20 mm/hour during the storm. High water marks and floodplain deposition sites were mapped using kinematic GPS surveying with post-processed differential correction, and sediment deposition was measured. The surveyed data were superimposed on an available two-foot-interval contour map to create an inundation map and a GIS point coverage of sediment deposition. Landscape attributes relevant to floodplain sedimentation were assessed and a sediment deposition potential map was created at the 30-m scale using a matrix of landscape characteristics that included: land use; roughness (influenced by vegetation type and density); channel and hillslope sediment sources (influenced by soils, geology, and cutbank erosion); slope and topography; and geomorphic terrain type. A calculation of sediment deposition potential was developed within a GIS that accounts for all contributing factors and illustrates that floodplain deposition is dominated by localized sedimentation, reflecting

Microbial community composition and trophic role along a marked salinity gradient in Laguna Puilar, Salar de Atacama, Chile.

PubMed

Dorador, Cristina; Fink, Patrick; Hengst, Martha; Icaza, Gonzalo; Villalobos, Alvaro S; Vejar, Drina; Meneses, Daniela; Zadjelovic, Vinko; Burmann, Lisa; Moelzner, Jana; Harrod, Chris

2018-05-09

The geological, hydrological and microbiological features of the Salar de Atacama, the most extensive evaporitic sedimentary basin in the Atacama Desert of northern Chile, have been extensively studied. In contrast, relatively little attention has been paid to the composition and roles of microbial communities in hypersaline lakes which are a unique feature in the Salar. In the present study biochemical, chemical and molecular biological tools were used to determine the composition and roles of microbial communities in water, microbial mats and sediments along a marked salinity gradient in Laguna Puilar which is located in the "Los Flamencos" National Reserve. The bacterial communities at the sampling sites were dominated by members of the phyla Bacteroidetes, Chloroflexi, Cyanobacteria and Proteobacteria. Stable isotope and fatty acid analyses revealed marked variability in the composition of microbial mats at different sampling sites both horizontally (at different sites) and vertically (in the different layers). The Laguna Puilar was shown to be a microbially dominated ecosystem in which more than 60% of the fatty acids at particular sites are of bacterial origin. Our pioneering studies also suggest that the energy budgets of avian consumers (three flamingo species) and dominant invertebrates (amphipods and gastropods) use minerals as a source of energy and nutrients. Overall, the results of this study support the view that the Salar de Atacama is a heterogeneous and fragile ecosystem where small changes in environmental conditions may alter the balance of microbial communities with possible consequences at different trophic levels.

Method to identify wells that yield water that will be replaced by water from the Colorado River downstream from Laguna Dam in Arizona and California

USGS Publications Warehouse

Owen-Joyce, Sandra J.; Wilson, Richard P.; Carpenter, Michael C.; Fink, James B.

2000-01-01

Accounting for the use of Colorado River water is required by the U.S. Supreme Court decree, 1964, Arizona v. California. Water pumped from wells on the flood plain and from certain wells on alluvial slopes outside the flood plain is presumed to be river water and is accounted for as Colorado River water. The accounting-surface method developed for the area upstream from Laguna Dam was modified for use downstream from Laguna Dam to identify wells outside the flood plain of the lower Colorado River that yield water that will be replaced by water from the river. Use of the same method provides a uniform criterion of identification for all users pumping water from wells by determining if the static water-level elevation in the well is above or below the elevation of the accounting surface. Wells that have a static water-level elevation equal to or below the accounting surface are presumed to yield water that will be replaced by water from the Colorado River. Wells that have a static water-level elevation above the accounting surface are presumed to yield river water stored above river level. The method is based on the concept of a river aquifer and an accounting surface within the river aquifer. The river aquifer consists of permeable sediments and sedimentary rocks that are hydraulically connected to the Colorado River so that water can move between the river and the aquifer in response to withdrawal of water from the aquifer or differences in water-level elevations between the river and the aquifer. The subsurface limit of the river aquifer is the nearly impermeable bedrock of the bottom and sides of the basins that underlie the Yuma area and adjacent valleys. The accounting surface represents the elevation and slope of the unconfined static water table in the river aquifer outside the flood plain of the Colorado River that would exist if the river were the only source of water to the river aquifer. The accounting surface was generated by using water

Characterization of Pustular Mats and Related Rivularia-Rich Laminations in Oncoids From the Laguna Negra Lake (Argentina).

PubMed

Mlewski, Estela C; Pisapia, Céline; Gomez, Fernando; Lecourt, Lena; Soto Rueda, Eliana; Benzerara, Karim; Ménez, Bénédicte; Borensztajn, Stephan; Jamme, Frédéric; Réfrégiers, Matthieu; Gérard, Emmanuelle

2018-01-01

Stromatolites are organo-sedimentary structures that represent some of the oldest records of the early biosphere on Earth. Cyanobacteria are considered as a main component of the microbial mats that are supposed to produce stromatolite-like structures. Understanding the role of cyanobacteria and associated microorganisms on the mineralization processes is critical to better understand what can be preserved in the laminated structure of stromatolites. Laguna Negra (Catamarca, Argentina), a high-altitude hypersaline lake where stromatolites are currently formed, is considered as an analog environment of early Earth. This study aimed at characterizing carbonate precipitation within microbial mats and associated oncoids in Laguna Negra. In particular, we focused on carbonated black pustular mats. By combining Confocal Laser Scanning Microscopy, Scanning Electron Microscopy, Laser Microdissection and Whole Genome Amplification, Cloning and Sanger sequencing, and Focused Ion Beam milling for Transmission Electron Microscopy, we showed that carbonate precipitation did not directly initiate on the sheaths of cyanobacterial Rivularia , which dominate in the mat. It occurred via organo-mineralization processes within a large EPS matrix excreted by the diverse microbial consortium associated with Rivularia where diatoms and anoxygenic phototrophic bacteria were particularly abundant. By structuring a large microbial consortium, Rivularia should then favor the formation of organic-rich laminations of carbonates that can be preserved in stromatolites. By using Fourier Transform Infrared spectroscopy and Synchrotron-based deep UV fluorescence imaging, we compared laminations rich in structures resembling Rivularia to putatively chemically-precipitated laminations in oncoids associated with the mats. We showed that they presented a different mineralogy jointly with a higher content in organic remnants, hence providing some criteria of biogenicity to be searched for in the fossil

Characterization of Pustular Mats and Related Rivularia-Rich Laminations in Oncoids From the Laguna Negra Lake (Argentina)

PubMed Central

Mlewski, Estela C.; Pisapia, Céline; Gomez, Fernando; Lecourt, Lena; Soto Rueda, Eliana; Benzerara, Karim; Ménez, Bénédicte; Borensztajn, Stephan; Jamme, Frédéric; Réfrégiers, Matthieu; Gérard, Emmanuelle

2018-01-01

Stromatolites are organo-sedimentary structures that represent some of the oldest records of the early biosphere on Earth. Cyanobacteria are considered as a main component of the microbial mats that are supposed to produce stromatolite-like structures. Understanding the role of cyanobacteria and associated microorganisms on the mineralization processes is critical to better understand what can be preserved in the laminated structure of stromatolites. Laguna Negra (Catamarca, Argentina), a high-altitude hypersaline lake where stromatolites are currently formed, is considered as an analog environment of early Earth. This study aimed at characterizing carbonate precipitation within microbial mats and associated oncoids in Laguna Negra. In particular, we focused on carbonated black pustular mats. By combining Confocal Laser Scanning Microscopy, Scanning Electron Microscopy, Laser Microdissection and Whole Genome Amplification, Cloning and Sanger sequencing, and Focused Ion Beam milling for Transmission Electron Microscopy, we showed that carbonate precipitation did not directly initiate on the sheaths of cyanobacterial Rivularia, which dominate in the mat. It occurred via organo-mineralization processes within a large EPS matrix excreted by the diverse microbial consortium associated with Rivularia where diatoms and anoxygenic phototrophic bacteria were particularly abundant. By structuring a large microbial consortium, Rivularia should then favor the formation of organic-rich laminations of carbonates that can be preserved in stromatolites. By using Fourier Transform Infrared spectroscopy and Synchrotron-based deep UV fluorescence imaging, we compared laminations rich in structures resembling Rivularia to putatively chemically-precipitated laminations in oncoids associated with the mats. We showed that they presented a different mineralogy jointly with a higher content in organic remnants, hence providing some criteria of biogenicity to be searched for in the fossil

DNA barcoding of fishes of Laguna de Bay, Philippines.

PubMed

Aquino, Luis Miguel G; Tango, Jazzlyn M; Canoy, Reynand Jay C; Fontanilla, Ian Kendrich C; Basiao, Zubaida U; Ong, Perry S; Quilang, Jonas P

2011-08-01

Laguna de Bay, the largest lake in the Philippines, is an important part of the country's fisheries industry. It is also home to a number of endemic fishes including Gobiopterus lacustris (Herre 1927) of family Gobiidae, Leiopotherapon plumbeus (Kner 1864) of family Terapontidae, Zenarchopterus philippinus (Peters 1868) of family Hemiramphidae and Arius manillensis Valenciennes 1840 of family Ariidae. Over the years, a steady decline has been observed in the abundance and diversity of native fishes in the lake due to anthropogenic disturbances. In this study, a total of 71 specimens of 18 different species belonging to 18 genera, 16 families, and seven orders were DNA barcoded using the mitochondrial cytochrome c oxidase subunit I (COI) gene. All of the fish species were discriminated by their COI sequences and one endemic species G. lacustris, showing deep genetic divergence, was highlighted for further taxonomic investigation. Average Kimura 2-parameter genetic distances within species, family, and order were 1.33%, 18.91%, and 24.22%, respectively. These values show that COI divergence increases as taxa become less exclusive. All of the COI sequences obtained were grouped together according to their species designation in the Neighbor-joining tree that was constructed. This study demonstrated that DNA barcoding has great potential as a tool for fast and accurate species identification and also for highlighting species that warrant further taxonomic investigation.

Frequency of event deposits reflecting glacial/interglacial conditions during the last ca. 50,000 years in the south Patagonian maar lake Laguna Potrok Aike, Argentina

NASA Astrophysics Data System (ADS)

Kliem, Pierre; Hahn, Annette; Ohlendorf, Christian; Zolitschka, Bernd; Pasado Science Team

2010-05-01

Laguna Potrok Aike is a 100m deep maar lake located in the dry steppe of southern Patagonia. The catchment area of >200km² mainly consists of till from Bella Vista and Río Ciaike Glaciations as well as of alkali-olivine basalts of the Pali Aike Volcanic Field. Today's regional climate is affected by the Southern Hemispheric Westerlies and the rainshadow effect of the north-south striking Andean mountain chain. Since lakes are valuable terrestrial paleoclimate archives, sediments of Laguna Potrok Aike should reflect shifts of mid latitude wind and pressure fields as well as precipitation changes in southeastern South America. Aiming at the reconstruction of past climate, the deep drilling at Laguna Potrok Aike was accomplished in the framework of the ICDP project PASADO during Sept. to Dec. 2008. By correlation of three holes drilled at Site 2 ca. 700 m south of the lake's center, a composite profile of 106.09 mcd (meters composite depth) was established. According to the lowermost 14C-age of aquatic macro remains from 80.6 mcd, the entire record comprises at least 50,000 years. The initial lithological description indicates that 50.74 m (i.e. 47.8%) of the sediment record consists of remobilized sediment (turbidity currents; homogenites; ball and pillow structures, gravel layers, slumps). Such deposits are almost absent in the top 12 mcd, where laminated clays and silts dominate. Correlation with an existing piston core allows a temporal relation to the Holocene. Apart from obviously remobilized deposits Holocene sediments are distinguished from Late Glacial deposits by a lower frequency of coarse silt/fine sand layers within a silt/clay matrix. Frequency and thickness of remobilized deposits increase with sediment depth. Most reworked sections are composed of three units: (1) a dark, coarse and fining upward base overlain by (2) a homogeneous layer of silt and (3) clay capped by a relatively thin light colored clay layer. Such sequences were often described as

The ambient acoustic environment in Laguna San Ignacio, Baja California Sur, Mexico.

PubMed

Seger, Kerri D; Thode, Aaron M; Swartz, Steven L; Urbán, Jorge R

2015-11-01

Each winter gray whales (Eschrichtius robustus) breed and calve in Laguna San Ignacio, Mexico, where a robust, yet regulated, whale-watching industry exists. Baseline acoustic environments in LSI's three zones were monitored between 2008 and 2013, in anticipation of a new road being paved that will potentially increase tourist activity to this relatively isolated location. These zones differ in levels of both gray whale usage and tourist activity. Ambient sound level distributions were computed in terms of percentiles of power spectral densities. While these distributions are consistent across years within each zone, inter-zone differences are substantial. The acoustic environment in the upper zone is dominated by snapping shrimp that display a crepuscular cycle. Snapping shrimp also affect the middle zone, but tourist boat transits contribute to noise distributions during daylight hours. The lower zone has three source contributors to its acoustic environment: snapping shrimp, boats, and croaker fish. As suggested from earlier studies, a 300 Hz noise minimum exists in both the middle and lower zones of the lagoon, but not in the upper zone.

Response of shoal grass, Halodule wrightii, to extreme winter conditions in the Lower Laguna Madre, Texas

USGS Publications Warehouse

Hicks, D.W.; Onuf, C.P.; Tunnell, J.W.

1998-01-01

Effects of a severe freeze on the shoal grass, Halodule wrightii, were documented through analysis of temporal and spatial trends in below-ground biomass. The coincidence of the second lowest temperature (-10.6??C) in 107 years of record, 56 consecutive hours below freezing, high winds and extremely low water levels exposed the Laguna Madre, TX, to the most severe cold stress in over a century. H. wrightii tolerated this extreme freeze event. Annual pre- and post-freeze surveys indicated that below-ground biomass estimated from volume was Unaffected by the freeze event. Nor was there any post-freeze change in biomass among intertidal sites directly exposed to freezing air temperatures relative to subtidal sites which remained submerged during the freezing period.

Uranium mobility and accumulation along the Rio Paguate, Jackpile Mine in Laguna Pueblo, NM.

PubMed

Blake, Johanna M; De Vore, Cherie L; Avasarala, Sumant; Ali, Abdul-Mehdi; Roldan, Claudia; Bowers, Fenton; Spilde, Michael N; Artyushkova, Kateryna; Kirk, Matthew F; Peterson, Eric; Rodriguez-Freire, Lucia; Cerrato, José M

2017-04-19

The mobility and accumulation of uranium (U) along the Rio Paguate, adjacent to the Jackpile Mine, in Laguna Pueblo, New Mexico was investigated using aqueous chemistry, electron microprobe, X-ray diffraction and spectroscopy analyses. Given that it is not common to identify elevated concentrations of U in surface water sources, the Rio Paguate is a unique site that concerns the Laguna Pueblo community. This study aims to better understand the solid chemistry of abandoned mine waste sediments from the Jackpile Mine and identify key hydrogeological and geochemical processes that affect the fate of U along the Rio Paguate. Solid analyses using X-ray fluorescence determined that sediments located in the Jackpile Mine contain ranges of 320 to 9200 mg kg -1 U. The presence of coffinite, a U(iv)-bearing mineral, was identified by X-ray diffraction analyses in abandoned mine waste solids exposed to several decades of weathering and oxidation. The dissolution of these U-bearing minerals from abandoned mine wastes could contribute to U mobility during rain events. The U concentration in surface waters sampled closest to mine wastes are highest during the southwestern monsoon season. Samples collected from September 2014 to August 2016 showed higher U concentrations in surface water adjacent to the Jackpile Mine (35.3 to 772 μg L -1 ) compared with those at a wetland 4.5 kilometers downstream of the mine (5.77 to 110 μg L -1 ). Sediments co-located in the stream bed and bank along the reach between the mine and wetland had low U concentrations (range 1-5 mg kg -1 ) compared to concentrations in wetland sediments with higher organic matter (14-15%) and U concentrations (2-21 mg kg -1 ). Approximately 10% of the total U in wetland sediments was amenable to complexation with 1 mM sodium bicarbonate in batch experiments; a decrease of U concentration in solution was observed over time in these experiments likely due to re-association with sediments in the reactor. The findings

Onboard Science Insights and Vehicle Dynamics from Scale-Model Trials of the Titan Mare Explorer (TiME) Capsule at Laguna Negra, Chile.

PubMed

Lorenz, Ralph D; Cabrol, Nathalie A

2018-05-01

A scale model of the proposed Titan Mare Explorer capsule was deployed at the Planetary Lake Lander field site at Laguna Negra, Chile. The tests served to calibrate models of wind-driven drift of the capsule and to understand its attitude motion in the wave field, as well as to identify dynamic and acoustic signatures of shoreline approach. This information enables formulation of onboard trigger criteria for near-shore science data acquisition. Key Words: Titan-Vehicle dynamics-Science autonomy-Lake. Astrobiology 18, 607-618.

Laguna Negra Virus Infection Causes Hantavirus Pulmonary Syndrome in Turkish Hamsters (Mesocricetus brandti).

PubMed

Hardcastle, K; Scott, D; Safronetz, D; Brining, D L; Ebihara, H; Feldmann, H; LaCasse, R A

2016-01-01

Laguna Negra virus (LNV) is a New World hantavirus associated with severe and often fatal cardiopulmonary disease in humans, known as hantavirus pulmonary syndrome (HPS). Five hamster species were evaluated for clinical and serologic responses following inoculation with 4 hantaviruses. Of the 5 hamster species, only Turkish hamsters infected with LNV demonstrated signs consistent with HPS and a fatality rate of 43%. Clinical manifestations in infected animals that succumbed to disease included severe and rapid onset of dyspnea, weight loss, leukopenia, and reduced thrombocyte numbers as compared to uninfected controls. Histopathologic examination revealed lung lesions that resemble the hallmarks of HPS in humans, including interstitial pneumonia and pulmonary edema, as well as generalized infection of endothelial cells and macrophages in major organ tissues. Histologic lesions corresponded to the presence of viral antigen in affected tissues. To date, there have been no small animal models available to study LNV infection and pathogenesis. The Turkish hamster model of LNV infection may be important in the study of LNV-induced HPS pathogenesis and development of disease treatment and prevention strategies. © The Author(s) 2015.

Diurnal vocal activity of gray whales in Laguna San Ignacio, BCS, Mexico

NASA Astrophysics Data System (ADS)

Guerra, Melania; Thode, Aaron; Wisdom, Sheyna; Gonzalez, Sergio; Urban, Jorge; Sumich, James

2005-09-01

Three sets of portable horizontal acoustic arrays were deployed during a week in February 2005 to gather acoustic recordings of gray whales (Eschrichtius robustus) in Laguna San Ignacio, one of the three major breeding/calving lagoons in Baja California, Mexico. These arrays, which were constructed by attaching a pair of autonomous flash-memory acoustic sensors to a rope, were deployed for 36 consecutive hours on two occasions, spatially covering the narrowest point of the lagoon near Punta Piedra, the area of the highest concentration of whales. Additionally a single hydrophone was deployed off a small boat to record during friendly encounters with single whales and cow/calf pairs. Each recorder's time series was analyzed for Type 1 gray whale sounds (called pops), which are pulsive, broadband, and have substantial acoustic energy between 100 and 600 Hz. The number of automated acoustic detections per hour can be compared with population sizes estimated by two visual surveys conducted by scientists of the Autonomous University of Baja California Sur, La Paz. The results of several automated analyses of both the bottom-mounted and boat-deployed recordings will be presented, with a focus on potential diurnal patterns in the vocal activity.

Estimating floodplain sedimentation in the Laguna de Santa Rosa, Sonoma County, CA

USGS Publications Warehouse

Curtis, Jennifer A.; Flint, Lorraine E.; Hupp, Cliff R.

2013-01-01

We present a conceptual and analytical framework for predicting the spatial distribution of floodplain sedimentation for the Laguna de Santa Rosa, Sonoma County, CA. We assess the role of the floodplain as a sink for fine-grained sediment and investigate concerns regarding the potential loss of flood storage capacity due to historic sedimentation. We characterized the spatial distribution of sedimentation during a post-flood survey and developed a spatially distributed sediment deposition potential map that highlights zones of floodplain sedimentation. The sediment deposition potential map, built using raster files that describe the spatial distribution of relevant hydrologic and landscape variables, was calibrated using 2 years of measured overbank sedimentation data and verified using longer-term rates determined using dendrochronology. The calibrated floodplain deposition potential relation was used to estimate an average annual floodplain sedimentation rate (3.6 mm/year) for the ~11 km2 floodplain. This study documents the development of a conceptual model of overbank sedimentation, describes a methodology to estimate the potential for various parts of a floodplain complex to accumulate sediment over time, and provides estimates of short and long-term overbank sedimentation rates that can be used for ecosystem management and prioritization of restoration activities.

Climate variability during the deglaciation and Holocene in a high-altitude alpine lake deduced from the sedimentary record from Laguna Seca, Sierra Nevada, southern Iberian Peninsula

NASA Astrophysics Data System (ADS)

Camuera, Jon; Jiménez-Moreno, Gonzalo; José Ramos-Román, María; García-Alix, Antonio; Jiménez-Espejo, Francisco; Anderson, R. Scott

2017-04-01

High-resolution X-ray fluorescence (XRF), magnetic susceptibility (MS), color and lithological analyses have been carried out on a 3.6 m-long sediment core from Laguna Seca, a high-elevation dry lake from Sierra Nevada mountain range, southern Spain. This is the longest sedimentary record retrieved from an alpine lake in southern Iberian Peninsula. Besides, alpine lakes are very sensitive environments to climate changes and previous studies showed that Laguna Seca could provide an excellent record to identify millennial-scale climate variations during deglaciation and the whole Holocene. XRF analyses, in particular high calcium and low K/Ca ratios, show aridity phases, very well represented during Last Glacial Maximum (LGM) and the Younger Dryas (YD). Arid events are also shown at ca. 8.1 ka BP, ca. 4.4 ka BP and the latest Holocene. On the other hand, negative values in calcium and positive values in K/Ca appear in the Bølling-Allerød (BA) and during the early Holocene until ca. 6 ka BP, indicating more humidity and higher run-off. A progressive aridification trend is also observed in the Holocene, changing from more humid conditions during the early Holocene to more aridity during the late Holocene.

Sr Isotopes and Migration of Prairie Mammoths (Mammuthus columbi) from Laguna de las Cruces, San Luis Potosi, Mexico

NASA Astrophysics Data System (ADS)

Solis-Pichardo, G.; Perez-Crespo, V.; Schaaf, P. E.; Arroyo-Cabrales, J.

2011-12-01

Asserting mobility of ancient humans is a major issue for anthropologists. For more than 25 years, Sr isotopes have been used as a resourceful tracer tool in this context. A comparison of the 87Sr/86Sr ratios found in tooth enamel and in bone is performed to determine if the human skeletal remains belonged to a local or a migrant. Sr in bone approximately reflects the isotopic composition of the geological region where the person lived before death; whereas the Sr isotopic system in tooth enamel is thought to remain as a closed system and thus conserves the isotope ratio acquired during childhood. Sr isotope ratios are obtained through the geologic substrate and its overlying soil, from where an individual got hold of food and water; these ratios are in turn incorporated into the dentition and skeleton during tissue formation. In previous studies from Teotihuacan, Mexico we have shown that a three-step leaching procedure on tooth enamel samples is important to assure that only the biogenic Sr isotope contribution is analyzed. The same Sr isotopic tools can function concerning ancient animal migration patterns. To determine or to discard the mobility of prairie mammoths (Mammuthus columbi) found at Laguna de las Cruces, San Luis Potosi, México the leaching procedure was applied on six molar samples from several fossil remains. The initial hypothesis was to use 87Sr/86Sr values to verify if the mammoth population was a mixture of individuals from various herds and further by comparing their Sr isotopic composition with that of plants and soils, to confirm their geographic origin. The dissimilar Sr results point to two distinct mammoth groups. The mammoth population from Laguna de Cruces was then not a family unit because it was composed by individuals originated from different localities. Only one individual was identified as local. Others could have walked as much as 100 km to find food and water sources.

76 FR 11773 - Environmental Management Site-Specific Advisory Board, Northern New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Northern New Mexico... the Environmental Management Site-Specific Advisory Board (EM SSAB), Northern New Mexico. The Federal... Courtyard by Marriott, 3347 Cerrillos Road, Santa Fe, New Mexico 87507. FOR FURTHER INFORMATION CONTACT...

Analysis of the ecosystem structure of Laguna Alvarado, western Gulf of Mexico, by means of a mass balance model

NASA Astrophysics Data System (ADS)

Cruz-Escalona, V. H.; Arreguín-Sánchez, F.; Zetina-Rejón, M.

2007-03-01

Alvarado is one of the most productive estuary-lagoon systems in the Mexican Gulf of Mexico. It has great economic and ecological importance due to high fisheries productivity and because it serves as a nursery, feeding, and reproduction area for numerous populations of fishes and crustaceans. Because of this, extensive studies have focused on biology, ecology, fisheries (e.g. shrimp, oysters) and other biological components of the system during the last few decades. This study presents a mass-balanced trophic model for Laguna Alvarado to determine it's structure and functional form, and to compare it with similar coastal systems of the Gulf of Mexico and Mexican Pacific coast. The model, based on the software Ecopath with Ecosim, consists of eighteen fish groups, seven invertebrate groups, and one group each of sharks and rays, marine mammals, phytoplankton, sea grasses and detritus. The acceptability of the model is indicated by the pedigree index (0.5) which range from 0 to 1 based on the quality of input data. The highest trophic level was 3.6 for marine mammals and snappers. Total system throughput reached 2680 t km -2 year -1, of which total consumption made up 47%, respiratory flows made up 37% and flows to detritus made up 16%. The total system production was higher than consumption, and net primary production higher than respiration. The mean transfer efficiency was 13.8%. The mean trophic level of the catch was 2.3 and the primary production required to sustain the catch was estimated in 31 t km -2 yr -1. Ecosystem overhead was 2.4 times the ascendancy. Results suggest a balance between primary production and consumption. In contrast with other Mexican coastal lagoons, Laguna Alvarado differs strongly in relation to the primary source of energy; here the primary producers (seagrasses) are more important than detritus pathways. This fact can be interpreted a response to mangrove deforest, overfishing, etc. Future work might include the compilation of

Lateglacial and Holocene climatic changes in south-eastern Patagonia inferred from carbonate isotope records of Laguna Potrok Aike (Argentina)

NASA Astrophysics Data System (ADS)

Oehlerich, M.; Mayr, C.; Gussone, N.; Hahn, A.; Hölzl, S.; Lücke, A.; Ohlendorf, C.; Rummel, S.; Teichert, B. M. A.; Zolitschka, B.

2015-04-01

First results of strontium, calcium, carbon and oxygen isotope analyses of bulk carbonates from a 106 m long sediment record of Laguna Potrok Aike, located in southern Patagonia are presented. Morphological and isotopic investigations of μm-sized carbonate crystals in the sediment reveal an endogenic origin for the entire Holocene. During this time period the calcium carbonate record of Laguna Potrok Aike turned out to be most likely ikaite-derived. As ikaite precipitation in nature has only been observed in a narrow temperature window between 0 and 7 °C, the respective carbonate oxygen isotope ratios serve as a proxy of hydrological variations rather than of palaeotemperatures. We suggest that oxygen isotope ratios are sensitive to changes of the lake water balance induced by intensity variations of the Southern Hemisphere Westerlies and discuss the role of this wind belt as a driver for climate change in southern South America. In combination with other proxy records the evolution of westerly wind intensities is reconstructed. Our data suggest that weak SHW prevailed during the Lateglacial and the early Holocene, interrupted by an interval with strengthened Westerlies between 13.4 and 11.3 ka cal BP. Wind strength increased at 9.2 ka cal BP and significantly intensified until 7.0 ka cal BP. Subsequently, the wind intensity diminished and stabilised to conditions similar to present day after a period of reduced evaporation during the "Little Ice Age". Strontium isotopes (87Sr/86Sr ratio) were identified as a potential lake-level indicator and point to a lowering from overflow conditions during the Glacial (∼17 ka cal BP) to lowest lake levels around 8 ka cal BP. Thereafter the strontium isotope curve resembles the lake-level curve which is stepwise rising until the "Little Ice Age". The variability of the Ca isotope composition of the sediment reflects changes in the Ca budget of the lake, indicating higher degrees of Ca utilisation during the period with

Impact of Water Resorts Development along Laguna de Bay on Groundwater Resources

NASA Astrophysics Data System (ADS)

Jago-on, K. A. B.; Reyes, Y. K.; Siringan, F. P.; Lloren, R. B.; Balangue, M. I. R. D.; Pena, M. A. Z.; Taniguchi, M.

2014-12-01

Rapid urbanization and land use changes in areas along Laguna de Bay, one of the largest freshwater lake in Southeast Asia, have resulted in increased economic activities and demand for groundwater resources from households, commerce and industries. One significant activity that can affect groundwater is the development of the water resorts industry, which includes hot springs spas. This study aims to determine the impact of the proliferation of these water resorts in Calamba and Los Banos, urban areas located at the southern coast of the lake on the groundwater as a resource. Calamba, being the "Hot Spring Capital of the Philippines", presently has more than 300 resorts, while Los Banos has at least 38 resorts. Results from an initial survey of resorts show that the swimming pools are drained/ changed on an average of 2-3 times a week or even daily during peak periods of tourist arrivals. This indicates a large demand on the groundwater. Monitoring of actual groundwater extraction is a challenge however, as most of these resorts operate without water use permits. The unrestrained exploitation of groundwater has resulted to drying up of older wells and decrease in hot spring water temperature. It is necessary to strengthen implementation of laws and policies, and enhance partnerships among government, private sector groups, civil society and communities to promote groundwater sustainability.

The stratified microbial community at Laguna Figueroa, Baja California, Mexico: A possible model for prephanerozoic laminated microbial communities preserved in cherts

NASA Astrophysics Data System (ADS)

Stolz, John F.; Margulis, Lynn

1984-12-01

The microbial mat community of the evaporite flat at North Pond, Laguna Figueroa (Baja California, Mexico) was actively involved in the production of laminated sediments prior to 1978. Heavy rains in 1979 and 1980 flooded the mat with 1 and 3 meters of meteoric water respectively. The flooding deposited up to 10 cm of silicoclastic sediment over theMicrocoleus-dominated mat and resulted in the cessation of laminated sediment deposition. In 1982, the surface had been recolonized by species of cyanobacteria (Spirulina, Oscillatoria) and purple photosynthetic bacteria (Chromatium, Thiocapsa). The silicoclastic sediments and residual evaporites, which overlaid the laminated sediment, had been reworked into an anaerobic, sulfide-rich mud and contained well preserved sheaths of filamentous and coccoid bacteria.

Model Studies of the Portugues and Bucana Rivers Channelization, Puerto Rico. Hydraulic Model Investigation.

DTIC Science & Technology

1978-05-01

Two 1:30-scale physical hydraulic models of the Portugues and Bucana Rivers were used to determine the adequacy of the original designs for the flood...transmit all expected flood releases from the proposed Portugues and Cerrillos Dams. Modifications to transitions at entrances to the high-velocity

Oldest Known Eucalyptus Macrofossils Are from South America

PubMed Central

Zamaloa, María C.; Nixon, Kevin C.; González, Cynthia C.; Wilf, Peter; Cúneo, N. Rubén; Johnson, Kirk R.

2011-01-01

The evolutionary history of Eucalyptus and the eucalypts, the larger clade of seven genera including Eucalyptus that today have a natural distribution almost exclusively in Australasia, is poorly documented from the fossil record. Little physical evidence exists bearing on the ancient geographical distributions or morphologies of plants within the clade. Herein, we introduce fossil material of Eucalyptus from the early Eocene (ca. 51.9 Ma) Laguna del Hunco paleoflora of Chubut Province, Argentina; specimens include multiple leaves, infructescences, and dispersed capsules, several flower buds, and a single flower. Morphological similarities that relate the fossils to extant eucalypts include leaf shape, venation, and epidermal oil glands; infructescence structure; valvate capsulate fruits; and operculate flower buds. The presence of a staminophore scar on the fruits links them to Eucalyptus, and the presence of a transverse scar on the flower buds indicates a relationship to Eucalyptus subgenus Symphyomyrtus. Phylogenetic analyses of morphological data alone and combined with aligned sequence data from a prior study including 16 extant eucalypts, one outgroup, and a terminal representing the fossils indicate that the fossils are nested within Eucalyptus. These are the only illustrated Eucalyptus fossils that are definitively Eocene in age, and the only conclusively identified extant or fossil eucalypts naturally occurring outside of Australasia and adjacent Mindanao. Thus, these fossils indicate that the evolution of the eucalypt group is not constrained to a single region. Moreover, they strengthen the taxonomic connections between the Laguna del Hunco paleoflora and extant subtropical and tropical Australasia, one of the three major ecologic-geographic elements of the Laguna del Hunco paleoflora. The age and affinities of the fossils also indicate that Eucalyptus subgenus Symphyomyrtus is older than previously supposed. Paleoecological data indicate that the

Oppression in Argentina: The Mataco Case. IWGIA Document No. 21.

ERIC Educational Resources Information Center

Rodriguez, Nemesio J.

The Mataco Indians are members of the Mataco-Mataguayo family which included several different groups that to some extent were related culturally speaking. According to the National Indigenous Census, there are 21,800 Mataco in Argentina today. The six Mataco settlements, situated in the land belt which extends from Pozo del Mortero to Laguna Yema…

Deglaciation in the High Andes - a Record from Laguna Piuray (Cusco, Peru)

NASA Astrophysics Data System (ADS)

Nederbragt, A.; Thurow, J.; Brumsack, H.; Lowe, J.; Pearce, R.; Ramsey, C.

2007-12-01

The Peruvian Andes lie in a crucial location for paleoclimate investigation. Fluctuating Pacific and Atlantic air masses compete for long-term dominance of the region, with the El-Nino Southern Oscillation (ENSO) system causing further variability. A laminated glacial/interglacial sediment sequence (6m) exposed around the shores of Laguna Piuray, near Cusco, offers not only the potential to reconstruct the climate history of the area but also to test for strength and frequency of the Atlantic monsoonal and Pacific ENSO influence. A suite of continuous cores was collected from deep trenches. The sedimentary record is characterized by postglacial diatom-rich chalk overlying organic-rich clayey chalk. Between these units are 3 distinct organic layers (80% TOC) deposited between 12-14 cal. kyr BP (14C). The base of the record is probably as old as 25kyrs (U/Th). We obtained a multi- proxy record of the section including continuous XRF scanning data of the entire sequence, and stable isotopes, XRF, XRD, TOC, biogenic opal, and carbonate analysis of discrete samples as well as a relative paleotemperature record from analyses of soil biomarkers. All the data profiles we obtained show a pronounced increase in temperature and decrease in precipitation at 13.8kyrs and are in good correlation with published regional Andean records using single proxies. Our results confirm that the Deglaciation Cold Reversal in central South America is not identical to the Younger Dryas event in the Northern Hemisphere.

Incidence of organochlorine pesticides and the health condition of nestling ospreys (Pandion haliaetus) at Laguna San Ignacio, a pristine area of Baja California Sur, Mexico.

PubMed

Rivera-Rodríguez, Laura B; Rodríguez-Estrella, Ricardo

2011-01-01

We identified and quantified organochlorine (OC) pesticide residues in the plasma of 28 osprey (Pandion haliaetus) nestlings from a dense population in Laguna San Ignacio, a pristine area of Baja California Sur, Mexico, during the 2001 breeding season. Sixteen OC pesticides were identified and quantified. α-, β-, δ- and γ-hexachlorocyclohexane, heptaclor, heptachlor epoxide, endosulfan I and II, endosulfan-sulfate, p,p'-DDE, p,p'-DDD, aldrin, dieldrin, endrin, endrin aldehyde, and endrin ketone were the OCs found in the plasma of nestlings, ranging from 0.002 to 6.856 pg/μl (parts per billion). No differences were found in the concentration of pesticides between genders (P > 0.05). In our work, the concentrations detected in the plasma were lower than those reported to be a threat for the species and that affect the survival and reproduction of birds. The presence of OC pesticides in the remote Laguna San Ignacio osprey population is an indication of the ubiquitous nature of these contaminants. OCs are apparently able to travel long distances from their source to the study area. A significant relationship between hemoglobin and mean corpuscular hemoglobin concentrations and OC concentrations were found suggesting that a potential effect on the health of chicks may exist in this osprey population caused by the OC, e.g. anemia. The total proteins were positively correlated with α-BHC, endosulfan I, and p,p'-DDD. It has been suggested that OC also affects competitive interactions and population status over the long term in vertebrate species, and our results could be used as reference information for comparison with other more exposed osprey populations.

The microbial community at laguna Figueroa, Baja California Mexico: From miles to microns

NASA Astrophysics Data System (ADS)

Stolz, John F.

1985-12-01

Laguna Figueroa is a lagoonal complex on the Pacific coast of the Baja California penisula 200 km south of the Mexican-United States border. The hypersaline lagoon is 16 km long and 2 3 km wide with a salt marsh and evaporite flat and is separated from the ocean by a barrier dune and beach. At the salt marsh-evaporite flat interface a stratified microbial community dominated byMicrocoleus chthonoplastes is depositing laminated sediments. Similar stratiform deposits with associated microbial mat communities have been found in cherts of the Fig Tree Group, South Africa which are 3.4 GE in age. Heavy rains in the winters of 1978 1979 and 1979 1980 flooded the evaporite flat with 1 3 meters of meteoric water and buried the laminated sediment under 5 10 cm of siliciclastic and clay sediment. These flooding events had a dramatic effect on the composition of the mat community. TheMicrocoleus dominated community, with species ofChloroflexus sp. and anEctothiorhodospira-like filamentous purple phototroph, disappeared leaving a community dominated by the purple phototrophsChromatium sp. andThiocapsa sp. Recolonization of the surface by species of the cyanobacteriaOscillatoria sp. andSpirulina sp. preceded the return of theMicrocoleus community. Field conditions were monitored by ground based observations and supplemented with LandSat and Skylab imagery. The microbial community was studied with light microscopy and transmission electron microscopy. The change in dominating microbial species was correlated with the episodes of flooding.

Late Holocene Lake Level Fluctuations at Laguna Arapa, Peru and Connections to Human Demography

NASA Astrophysics Data System (ADS)

Hillman, A. L.; Abbott, M. B.; Werne, J. P.; Arkush, E.; Thompson, L. G.; Ferland, T.; Holmes, E.; Puhnaty, C.; Woods, A.

2016-12-01

The relationship between variations in hydroclimate and human demography on the Peruvian Altiplano has significant implications for understanding how people in the past have adapted to changes in freshwater resources. To investigate these human-environmental interactions, this project presents a 2,000 year sediment record from Laguna Arapa, a large lake that is <20 km NW of Lake Titicaca. Using sedimentology and stratigraphy as well as a suite of organic geochemical proxies including fecal 5β-stanols and leaf waxes (long chain n-alkanoic acids), we aim to tie together proxies of human population with indicators of regional hydroclimate. Preliminary results of sedimentology and stratigraphy show notable transitions from sand to silt to clay, suggesting rising lake level sequences at 500 and 700 AD. The last 1,300 years of sediment are characterized by alternating layers of organic rich material with abundant charcoal and black inorganic clay, suggesting intermittent periods of aridity and/or anthropogenic fire-setting. These layers are particularly frequent during the Medieval Climate Anomaly, which was characterized by dry and warm conditions. These results agree well with other records of hydroclimate from regional lakes as well as accumulation rate and temperature from the Quelccaya ice cap. Organic geochemical work is currently in progress and shows promise for linking together proxies of human demography with hydroclimate to understand the relationship between human settlement and climate change.

Distinguishing megathrust from intraplate earthquakes using lacustrine turbidites (Laguna Lo Encañado, Central Chile)

NASA Astrophysics Data System (ADS)

Van Daele, Maarten; Araya-Cornejo, Cristian; Pille, Thomas; Meyer, Inka; Kempf, Philipp; Moernaut, Jasper; Cisternas, Marco

2017-04-01

One of the main challenges in seismically active regions is differentiating paleo-earthquakes resulting from different fault systems, such as the megathrust versus intraplate faults in subductions settings. Such differentiation is, however, key for hazard assessments based on paleoseismic records. Laguna Lo Encañado (33.7°S; 70.3°W; 2492 m a.s.l.) is located in the Central Chilean Andes, 50 km east of Santiago de Chile, a metropole with about 7,000,000 inhabitants. During the last century the study area experienced 3 large megathrust earthquakes (1906, 1985 and 2010) and 2 intraplate earthquakes (1945 and 1958) (Lomnitz, 1960). While the megathrust earthquakes cause Modified Mercalli Intensities (MMIs) of VI to VII at the lake (Van Daele et al., 2015), the intraplate earthquakes cause peak MMIs up to IX (Sepúlveda et al., 2008). Here we present a turbidite record of Laguna Lo Encañado going back to 1900 AD. While geophysical data (3.5 kHz subbottom seismic profiles and side-scan sonar data) provides a bathymetry and an overview of the sedimentary environment, we study 15 short cores in order to understand the depositional processes resulting in the encountered lacustrine turbidites. All mentioned earthquakes triggered turbidites in the lake, which are all linked to slumps in proximal areas, and are thus resulting from mass wasting of the subaquatic slopes. However, turbidites linked to the intraplate earthquakes are additionally covered by turbidites of a finer-grained, more clastic nature. We link the latter to post-seismic erosion of onshore landslides, which need higher MMIs to be triggered than subaquatic mass movements (Howarth et al., 2014). While intraplate earthquakes can cause MMIs up to IX and higher, megathrust earthquakes do not cause sufficiently high MMIs at the lake to trigger voluminous onshore landslides. Hence, the presence of these post-seismic turbidites allows to distinguish turbidites triggered by intraplate earthquakes from those

Early and mid-Holocene age for the Tempanos moraines, Laguna San Rafael, Patagonian Chile

NASA Astrophysics Data System (ADS)

Harrison, Stephan; Glasser, Neil F.; Duller, Geoff A. T.; Jansson, Krister N.

2012-01-01

Data about the nature and timing of Holocene events from the Southern Hemisphere, especially in southern South America, are required to provide insight into the extent and nature of past climate change in a region where land-based records are restricted. Here we present the first use of single grain Optically Stimulated Luminescence (OSL) dating of a moraine sequence recording glacial advance along the western side of the Patagonian Icefields. Dates from the Tempanos moraines at Laguna San Rafael (LSR) show that the San Rafael Glacier (SRG) advanced to maximum Holocene positions during the period 9.3 to 9.7 ka and at 5.7 ka. Outwash lying beneath the moraine in its northern portion, dated to 7.7 ka, indicates that the glacier front was also advanced at this time. Since these advances span both the regional early Holocene warm-dry phase (11.5 ka to 7.8 ka) and the subsequent cooling and rise in precipitation in the mid-late Holocene (since 6.6 ka) we infer that the advances of the SRG are not simply climate-driven, but that the glacier has also probably responded strongly to non-climatic stimuli such as internal ice dynamics and the transition between calving and non-calving. Many westwards-flowing glaciers in Patagonia were probably calving during much of the Late Pleistocene and Holocene, so we conclude that establishing robust glacial chronologies where climatic and non-climatic factors cannot be distinguished is likely to remain a challenge.

Hydrologic, water-quality, and biological assessment of Laguna de las Salinas, Ponce, Puerto Rico, January 2003-September 2004

USGS Publications Warehouse

Soler-López, Luis R.; Gómez-Gómez, Fernando; Rodríguez-Martínez, Jesús

2005-01-01

The Laguna de Las Salinas is a shallow, 35-hectare, hypersaline lagoon (depth less than 1 meter) in the municipio of Ponce, located on the southern coastal plain of Puerto Rico. Hydrologic, water-quality, and biological data in the lagoon were collected between January 2003 and September 2004 to establish baseline conditions. During the study period, rainfall was about 1,130 millimeters, with much of the rain recorded during three distinct intense events. The lagoon is connected to the sea by a shallow, narrow channel. Subtle tidal changes, combined with low rainfall and high evaporation rates, kept the lagoon at salinities above that of the sea throughout most of the study. Water-quality properties measured on-site (temperature, pH, dissolved oxygen, specific conductance, and Secchi disk transparency) exhibited temporal rather than spatial variations and distribution. Although all physical parameters were in compliance with current regulatory standards for Puerto Rico, hyperthermic and hypoxic conditions were recorded during isolated occasions. Nutrient concentrations were relatively low and in compliance with current regulatory standards (less than 5.0 and 1.0 milligrams per liter for total nitrogen and total phosphorus, respectively). The average total nitrogen concentration was 1.9 milligrams per liter and the average total phosphorus concentration was 0.4 milligram per liter. Total organic carbon concentrations ranged from 12.0 to 19.0 milligrams per liter. Chlorophyll a was the predominant form of photosynthetic pigment in the water. The average chlorophyll a concentration was 13.4 micrograms per liter. Chlorophyll b was detected (detection limits 0.10 microgram per liter) only twice during the study. About 90 percent of the primary productivity in the Laguna de Las Salinas was generated by periphyton such as algal mats and macrophytes such as seagrasses. Of the average net productivity of 13.6 grams of oxygen per cubic meter per day derived from the diel

Puerto Rico, humedales [Puerto Rico, wetlands

USGS Publications Warehouse

Adams, D. Briane; Hefner, John M.; Dopazo, Teresa

1999-01-01

descanso y la alimentación de cientos de aves migratorias en ruta entre Norte y Suramérica. Antes del drenaje de los humedales costeros para propósitos agrícolas, pantanos de agua dulce como los de la Laguna Cartagena, Laguna Guánica y Ciénaga El Anegado proveían hábitat a más de 1 00 especies de aves residentes y migratorias . Los humedales de las tierras altas del área central son el último refugio de la cotorra puertorriqueña, una especie en peligro de extinción. Aún los humedales del área metropolitana de San Juan (Laguna La Torrecilla, Torrecilla Baja, Laguna de Piñones hasta Punta Vacía Talega) proveen un hábitat excelente para la vida silvestre, mantienen criaderos de peces de alto valor económico y proveen recreación y oportunidades educativas a la población urbana.Treintiocho especies de vertebrados, moluscos y crustáceos, y 46 especies de aves, algunos raros o en peligro de extinción como la mariquita, el alcatraz, el pato dominicano, el pato silbón y la paloma cabeciblanca han sido observados en el área . También las playas asociadas con estos humedales urbanos proveen sitios de anidaje para las tortugas carey de concha y tinglar, ambas en peligro de extinción (Del Llano y otros, 1986).

Lithologic controls on mineralization at the Lagunas Norte high-sulfidation epithermal gold deposit, northern Peru

NASA Astrophysics Data System (ADS)

Cerpa, Luis M.; Bissig, Thomas; Kyser, Kurt; McEwan, Craig; Macassi, Arturo; Rios, Hugo W.

2013-06-01

The 13.1-Moz high-sulfidation epithermal gold deposit of Lagunas Norte, Alto Chicama District, northern Peru, is hosted in weakly metamorphosed quartzites of the Upper Jurassic to Lower Cretaceous Chimú Formation and in overlying Miocene volcanic rocks of dacitic to rhyolitic composition. The Dafne and Josefa diatremes crosscut the quartzites and are interpreted to be sources of the pyroclastic volcanic rocks. Hydrothermal activity was centered on the diatremes and four hydrothermal stages have been defined, three of which introduced Au ± Ag mineralization. The first hydrothermal stage is restricted to the quartzites of the Chimú Formation and is characterized by silice parda, a tan-colored aggregate of quartz-auriferous pyrite-rutile ± digenite infilling fractures and faults, partially replacing silty beds and forming cement of small hydraulic breccia bodies. The δ34S values for pyrite (1.7-2.2 ‰) and digenite (2.1 ‰) indicate a magmatic source for the sulfur. The second hydrothermal stage resulted in the emplacement of diatremes and the related volcanic rocks. The Dafne diatreme features a relatively impermeable core dominated by milled slate from the Chicama Formation, whereas the Josefa diatreme only contains Chimú Formation quartzite clasts. The third hydrothermal stage introduced the bulk of the mineralization and affected the volcanic rocks, the diatremes, and the Chimú Formation. In the volcanic rocks, classic high-sulfidation epithermal alteration zonation exhibiting vuggy quartz surrounded by a quartz-alunite and a quartz-alunite-kaolinite zone is observed. Company data suggest that gold is present in solid solution or micro inclusions in pyrite. In the quartzite, the alteration is subtle and is manifested by the presence of pyrophyllite or kaolinite in the silty beds, the former resulting from relatively high silica activities in the fluid. In the quartzite, gold mineralization is hosted in a fracture network filled with coarse alunite

Linking microbial assemblages to paleoenvironmental conditions from the Holocene and Last Glacial Maximum times in Laguna Potrok Aike sediments, Argentina

NASA Astrophysics Data System (ADS)

Vuillemin, Aurele; Ariztegui, Daniel; Leavitt, Peter R.; Bunting, Lynda

2014-05-01

Laguna Potrok Aike is a closed basin located in the southern hemisphere's mid-latitudes (52°S) where paleoenvironmental conditions were recorded as temporal sedimentary sequences resulting from variations in the regional hydrological regime and geology of the catchment. The interpretation of the limnogeological multiproxy record developed during the ICDP-PASADO project allowed the identification of contrasting time windows associated with the fluctuations of Southern Westerly Winds. In the framework of this project, a 100-m-long core was also dedicated to a detailed geomicrobiological study which aimed at a thorough investigation of the lacustrine subsurface biosphere. Indeed, aquatic sediments do not only record past climatic conditions, but also provide a wide range of ecological niches for microbes. In this context, the influence of environmental features upon microbial development and survival remained still unexplored for the deep lacustrine realm. Therefore, we investigated living microbes throughout the sedimentary sequence using in situ ATP assays and DAPI cell count. These results, compiled with pore water analysis, SEM microscopy of authigenic concretions and methane and fatty acid biogeochemistry, provided evidence for a sustained microbial activity in deep sediments and pinpointed the substantial role of microbial processes in modifying initial organic and mineral fractions. Finally, because the genetic material associated with microorganisms can be preserved in sediments over millennia, we extracted environmental DNA from Laguna Potrok Aike sediments and established 16S rRNA bacterial and archaeal clone libraries to better define the use of DNA-based techniques in reconstructing past environments. We focused on two sedimentary horizons both displaying in situ microbial activity, respectively corresponding to the Holocene and Last Glacial Maximum periods. Sequences recovered from the productive Holocene record revealed a microbial community adapted to

Evaporative concentration of arsenic in groundwater: health and environmental implications, La Laguna Region, Mexico.

PubMed

Ortega-Guerrero, Adrián

2017-10-01

High arsenic concentrations in groundwater have been documented in La Laguna Region (LLR) in arid northern Mexico, where arsenic poisoning is both chronic and endemic. A heated debate has continued for decades on its origin. LLR consisted of a series of ancient connected lakes that developed at the end of a topographic depression under closed basin conditions. This study addresses the isotopic, chemical composition of the groundwater and geochemical modeling in the southeasternmost part of the LLR to determine the origin of arsenic. Groundwater samples were obtained from a carbonate and granular aquifers and from a clayey aquitard at terminal Viesca Lake. Results show that groundwater originated as meteoric water that reached the lakes mainly via abundant springs in the carbonate aquifer and perennial flooding of the Nazas-Aguanaval Rivers. Paleo-lake water underwent progressive evaporation as demonstrated by the enrichment of δ 18 O, δ 2 H and characteristic geochemical patterns in the granular aquifer and aquitard that resulted in highly saline (>90,000 mS/cm), arsenic-rich (up to 5000 μg/L) paleo-groundwater (>30,000 years BP). However, adsorption or co-precipitation on iron oxides, clay-mineral surfaces and organic carbon limited arsenic concentration in the groundwater. Arsenic-rich groundwater and other solutes are advancing progressively from the lacustrine margins toward the main granular aquifer, due to reversal of hydraulic gradients caused by intensive groundwater exploitation and the reduction in freshwater runoff provoked by dam construction on the main rivers. Desorption of arsenic will incorporate additional concentrations of arsenic into the groundwater and continue to have significant negative effects on human health and the environment.

Delta progradation and Neoglaciation, Laguna Parón, Cordillera Blanca, Peru

NASA Astrophysics Data System (ADS)

Seltzer, Geoffrey O.; Rodbell, Donald T.

2005-10-01

The history of Holocene glaciation serves as an important record of glacier mass balance and, therefore, of climatic change. The moraine record of Holocene glaciation in the tropical Andes, however, is fragmentary and poorly dated. In contrast, increases in the rate of accumulation of inorganic sediment in glacier-fed lakes have been linked to periods of Neoglaciation in many mountain regions. The interpretation of such a record of Neoglaciation from sediment cores in glacier-fed lakes in the tropical Andes can provide the continuity and chronologic control that is lacking in the existing moraine record. Unusual exposures of glacial lacustrine sediment in the Cordillera Blanca, Peru, provide a rare opportunity to assess the link between climatic change, glaciation, and lacustrine sedimentation.Intentional lowering of water levels in Laguna Parón (9°S, 77°44 W, 4200 m a.s.l.) in 1985 resulted in the incision and exposure of at least 20 m of deltaic deposits at the eastern end of the lake. Three deltaic units can be identified: horizontal topset beds, steeply dipping and deformed foreset beds, and horizontally laminated fine-grained sediment. Six radiocarbon ages ranging from 1800 +/- 210 to 465 +/- 95 14C yr BP on wood indicate that the average rate of delta progradation in the late Holocene has been approximately 290 m per 1000 yr. The lake formed during deglaciation at least 10 000 yr ago and if such a rate of progradation of the delta had prevailed over the entire Holocene, then the delta would be at least three times as extensive as it is today. Thus the rate of delta progradation has varied significantly over the Holocene. We suggest that the rate of delta progradation was at least three times greater when glaciers were in advanced positions. These positions are clearly delimited by Neoglacial moraines, which are within 1-2 km of the exposures studied and within 1 km of modern ice limits. The most recent increase in the rate of delta progradation is

DEL phenotype.

PubMed

Kwon, Dong H; Sandler, S G; Flegel, Willy A

2017-09-01

DEL red blood cells (RBCs) type as D- by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D- recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated with the RHD*DEL1 or RHD*01EL.01 allele. The prevalence of DEL phenotypes has been reported among D- Han Chinese (30%), Japanese (28%), and Korean (17%) populations. The prevalence of DEL phenotypes is significantly lower among D- Caucasian populations (0.1%). Among the 3-5 percent of African individuals who are D-, there are no reports of the DEL phenotype. Case reports from East Asia indicate that transfusion of DEL RBCs to D- recipients has been associated with D alloimmunization. East Asian immigrants constitute 2.1 percent of the 318.9 million persons residing in the United States, and an estimated 2.8 percent are blood donors. Using these statistics, we estimate that 68-683 units of DEL RBCs from donors of East Asian ancestry are transfused as D- annually in the United States. Given the reports from East Asia of D alloimmunization attributed to transfusion of DEL RBCs, one would expect an occasional report of D alloimmunization in the United States following transfusion of DEL RBCs to a D- recipient. If such cases do occur, the most likely reason that they are not detected is the absence of active post-transfusion monitoring for formation of anti-D.

Authorized and Operating Purposes of Corps of Engineers Reservoirs

DTIC Science & Technology

1992-07-01

Puerto Rico CERRILLOS DAM AND RESERVOIR Jacksonville E-9O PORTUGUES DAM AND RESERVOIR Jacksonville E-92 South Carolina HARTWELL DAM AND LAKE Savannah E...LAKE Missouri Kansas City E-12 POMONA LAKE Kansas Kansas City E-12 PORTUGUES DAM AND RESERVOIR Puerto Rico Jacksonville E-92 PRADO DAM (SANTA ANA...PROJECT Florida Jacksonville E-92 PORTUGUES DAM AND RESERVOIR Puerto Rico Jacksonville E-92 RODMAN LOCK AND DAM (CROSS FLORIDA BARGE CANAL Florida

Waterbirds and human-related threats to their conservation in Laguna Cuyutlán, Colima, México.

PubMed

Mellink, Eric; Riojas-López, Mónica

2009-01-01

Laguna Cuyutlán, the only large wetland in a span of 1,150 km along the Pacific coast of Mexico, has been neglected as to its importance for waterbird conservation. At least 25 waterbird species nest there, with some of their colonies being very relevant, and at least 61 waterbird species use the lagoon during their non-breeding season. This lagoon has been subject to several structural modifications, including levees and artificial channels which connect it to the sea, while water supply from continental sources has diminished, although its role has not been assessed yet. Salt extraction and artisanal fishery, the main economic activities, do not seem to pose a threat to waterbirds. Among potential threats to this acquatic ecosystem, are the raw sewage discharges that exist near urban areas, and pesticides from the surrounding agricultural lands might reach the lagoon. Seemingly, the most serious threat comes from waterway development in connection with a re-gasification plant to be built, and planned future port expansion, which could potentially increase water levels and alter important habitats for nesting and foraging. We recommend that: the area be declared an Important Bird Area; the development of the re-gasification plant and future port includes a levee to prevent alterations in water level in the remaining sections of the lagoon; supply of exogenous chemicals and waste products be prevented and monitored; alleged benefits from water interchange between the lagoon and the sea through artificial channels should be re-evaluated; and the role of fresh water supplies to the lagoon should be paid attention to.

Availability of ground water in parts of the Acoma and Laguna Indian Reservations, New Mexico

USGS Publications Warehouse

Dinwiddie, George A.; Motts, Ward Sundt

1964-01-01

The need for additional water has increased in recent years on the Acoma and Laguna Indian Reservations in west-central New Mexico because the population and per capita use of water have increased; the tribes also desire water for light industry, for more modern schools, and to increase their irrigation program. Many wells have been drilled in the area, but most have been disappointing because of small yields and poor chemical quality of the water. The topography in the Acoma and Laguna Indian Reservations is controlled primarily by the regional and local dip of alternating beds of sandstone and shale and by the igneous complex of Mount Taylor. The entrenched alluvial valley along the Rio San Jose, which traverses the area, ranges in width from about 0.4 mile to about 2 miles. The climate is characterized by scant rainfall, which occurs mainly in summer, low relative humidity, and large daily fluctuations of temperature. Most of the surface water enters the area through the Rio San Jose. The average annual streamflow past the gaging station Rio San Jose near Grants, N. Mex. is about 4,000 acre-feet. Tributaries to the Rio San Jose within the area probably contribute about 1,000 acre-feet per year. At the present time, most of the surface water is used for irrigation. Ground water is obtained from consolidated sedimentary rocks that range in age from Triassic to Cretaceous, and from unconsolidated alluvium of Quaternary age. The principal aquifers are the Dakota Sandstone, the Tres Hermanos Sandstone Member of the Mancos Shale, and the alluvium. The Dakota Sandstone yields 5 to 50 gpm (gallons per minute) of water to domestic and stock wells. The Tres Hermanos sandstone Member generally yields 5 to 20 gpm of water to domestic and stock wells. Locally, beds of sandstone in the Chinle and Morrison Formations, the Entrada Sandstone, and the Bluff Sandstone also yield small supplies of water to domestic and stock wells. The alluvium yields from 2 gpm to as much as 150

The diversity of Odonata and their endophytic ovipositions from the Upper Oligocene Fossillagerstätte of Rott (Rhineland, Germany)

PubMed Central

Petrulevičius, Julián F.; Wappler, Torsten; Nel, André; Rust, Jes

2011-01-01

Abstract A commented list of fossil Odonata from the Oligocene outcrop of Rott is given, together with descriptions of new traces of oviposition in plant tissues, very similar to ichnotaxa already known from the early Eocene Laguna del Hunco floras of Patagonia. The joint presences of odonatan larvae and traces of oviposition demonstrate the autochthony of these insects in the palaeolake of Rott, confirming the existence of a diverse and abundant aquatic entomofauna, a situation strikingly different to that in the contemporaneous Oligocene palaeolake of Céreste (France). PMID:22259267

Tdp studies and tests for C. A. Energia Electrica de Venezuela (enelven) at planta ramon laguna, units RL-17 and RL-10. Volume 2. Unit RL-10 boiler condition assessment report. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-03-28

The study, conducted by Babcock and Wilcox, was funded by the U.S. Trade and Development agency on behalf of Enelven. In order to maximize generated power output and minimize operating costs at Planta Ramon Laguna, tests were done to evaluate the condition of equipment at the plant. In order to identify any damage and determine the operating output of each unit, assessments were done of the furnaces, boilers, generators and boiler feed pumps being used in the plant. The report presents the results of these tests. This is the second of three volumes and it includes the following section: (1)more » Condition Assessment of Unit RL-10 Boiler.« less

Laguna Potrok Aike, Argentina: the first non-tropical environmental record in South America extending far beyond the Late-Glacial - a progress report

NASA Astrophysics Data System (ADS)

Zolitschka, B.; Anselmetti, F.; Ariztegui, D.; Corbella, H.; Francus, P.; Gebhardt, C.; Lücke, A.; Ohlendorf, C.; Schäbitz, F.; Pasado Science Team

2009-04-01

Within the framework of the ICDP-funded "Potrok Aike maar lake sediment archive drilling project" (PASADO) an international team of scientists carried out interdisciplinary research at the unique mid-Pleistocene (770 ka) maar lake of Laguna Potrok Aike in southern Patagonia (Province of Santa Cruz, Argentina). This lake is very sensitive to variations in southern hemispheric wind and pressure systems and thus holds a unique and continuous lacustrine record of climatic and ecological variability of global significance. Moreover, Southern Patagonia with its many active volcanoes is an ideal location to better understand the regional history of volcanism. These are two challenging geo-scientific themes that need to be tackled, especially as both of them have an increasing socio-economic relevance. Three months of drilling activities that finished last November 2008 were carried out by DOSECC from the drilling platform R/V "Kerry Kelts". More than 500 m of lacustrine sediments were recovered. This sedimentary archive will provide (1) new insights into the processes of regional back arc volcanism within the Pali Aike Volcanic Field itself as well as the more distant explosive volcanism of the Andean mountain chains; and, (2) high-resolution (decadal) quantitative climate and environmental reconstructions supported by multiple dating and stratigraphic correlations. Marine - ice core - terrestrial linkages will be emphasized as well as the incorporation of results from global climate modelling simulations for the last ca. 100 ka. The two drilled sites in the central deep basin of Laguna Potrok Aike have been selected based on four seismic surveys carried out between 2003 and 2005. Sediments were recovered at both drilled sites down to a subbottom depth of slightly more than 100 m using the GLAD800 drill rig with the hydraulic piston corer tool (HPC) at water depths varying between 95 and 100 m. The total core recovery is 94%. On-site core logging with the multi sensor

Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon.

PubMed

de Barros Lopes, Lívia; Guterres, Alexandro; Rozental, Tatiana; Carvalho de Oliveira, Renata; Mares-Guia, Maria Angélica; Fernandes, Jorlan; Figueredo, José Ferreira; Anschau, Inês; de Jesus, Sebastião; V Almeida, Ana Beatriz M; Cristina da Silva, Valéria; Gomes de Melo Via, Alba Valéria; Bonvicino, Cibele Rodrigues; D'Andrea, Paulo Sérgio; Barreira, Jairo Dias; Sampaio de Lemos, Elba Regina

2014-04-17

The purpose of this study was to identify the presence of rickettsia and hantavirus in wild rodents and arthropods in response to an outbreak of acute unidentified febrile illness among Indians in the Halataikwa Indian Reserve, northwest of the Mato Grosso state, in the Brazilian Amazon. Where previously surveillance data showed serologic evidence of rickettsia and hantavirus human infection. The arthropods were collected from the healthy Indian population and by flagging vegetation in grassland or woodland along the peridomestic environment of the Indian reserve. Wild rodents were live-trapped in an area bordering the reserve limits, due the impossibility of capturing wild animals in the Indian reserve. The wild rodents were identified based on external and cranial morphology and karyotype. DNA was extracted from spleen or liver samples of rodents and from invertebrate (tick and louse) pools, and the molecular characterization of the rickettsia was through PCR and DNA sequencing of fragments of two rickettsial genes (gltA and ompA). In relation to hantavirus, rodent serum samples were serologically screened by IgG ELISA using the Araraquara-N antigen and total RNA was extracted from lung samples of IgG-positive rodents. The amplification of the complete S segment was performed. A total of 153 wild rodents, 121 louse, and 36 tick specimens were collected in 2010. Laguna Negra hantavirus was identified in Calomys callidus rodents and Rickettsia bellii, Rickettsia amblyommii were identified in Amblyomma cajennense ticks. Zoonotic diseases such as HCPS and spotted fever rickettsiosis are a public health threat and should be considered in outbreaks and acute febrile illnesses among Indian populations. The presence of the genome of rickettsias and hantavirus in animals in this Indian reserve reinforces the need to include these infectious agents in outbreak investigations of febrile cases in Indian populations.

Holocene History of the Chocó Rain Forest from Laguna Piusbi, Southern Pacific Lowlands of Colombia

NASA Astrophysics Data System (ADS)

Behling, Hermann; Hooghiemstra, Henry; Negret, Alvaro José

1998-11-01

A high-resolution pollen record from a 5-m-long sediment core from the closed-lake basin Laguna Piusbi in the southern Colombian Pacific lowlands of Chocó, dated by 11 AMS 14C dates that range from ca. 7670 to 220 14C yr B.P., represents the first Holocene record from the Chocó rain forest area. The interval between 7600 and 6100 14C yr B.P. (500-265 cm), composed of sandy clays that accumulated during the initial phase of lake formation, is almost barren of pollen. Fungal spores and the presence of herbs and disturbance taxa suggest the basin was at least temporarily inundated and the vegetation was open. The closed lake basin might have formed during an earthquake, probably about 4400 14C yr B.P. From the interval of about 6000 14C yr B.P. onwards, 200 different pollen and spore types were identified in the core, illustrating a diverse floristic composition of the local rain forest. Main taxa are Moraceae/Urticaceae, Cecropia,Melastomataceae/Combretaceae, Acalypha, Alchornea,Fabaceae, Mimosa, Piper, Protium, Sloanea, Euterpe/Geonoma, Socratea,and Wettinia.Little change took place during that time interval. Compared to the pollen records from the rain forests of the Colombian Amazon basin and adjacent savannas, the Chocó rain forest ecosystem has been very stable during the late Holocene. Paleoindians probably lived there at least since 3460 14C yr B.P. Evidence of agricultural activity, shown by cultivation of Zea maissurrounding the lake, spans the last 1710 yr. Past and present very moist climate and little human influence are important factors in maintaining the stable ecosystem and high biodiversity of the Chocó rain forest.

Acerca del moho

EPA Pesticide Factsheets

El moho forma parte del medio ambiente natural. Afuera del hogar, el moho juega un papel en la naturaleza al desintegrar materias organicas tales como las hojas que se han caido o los arboles muertos. El moho puede crecer adentro del hogar cuando las espor

Produccion Gaseosa del Cometa Halley: Erupciones Y Fotodisociacion del Radical OH

NASA Astrophysics Data System (ADS)

Silva, A. M.; Mirabel, I. F.

1990-11-01

RESUMEN:En este trabajo informamos la detecci6n de 20 erupciones en la li'nea de =18cm (1667MHz) del radical OH en el Cometa Halley.Las observaciones incluyen todos los monitoreos existentes y se extienden desde 120 dias antes del perihelio hasta 90 dias despues.Se detectan bruscos crecimientos en el flujo medido,hasta un factor 1O,seguidos por decaimientos lentos asociados con la fotodisociaci6n del OH. Se obtuvieron valores para el tiempo de vida fotoquimico del OH y del H2O basandose en el modelo desarrollado previamente por Silva(1988). Esos tiempos de vida estan de acuerdo con predicciones teoricas y con las observaciones en el Ultravioleta, y los resultados, los que son fuertemente dependientes de la velocidad heliocentrica del Coineta (variando hasta un factor 6), han sido calculados para varios rangos de velocidad entre +28 y -28 km/seg. Key wo'L :

Morphological and geochemical variations of Cyprideis (Ostracoda) from modern waters of the northern Neotropics.

PubMed

Meyer, J; Wrozyna, C; Gross, M; Leis, A; Piller, W E

2017-01-01

The variability of modern Cyprideis salebrosa and Cyprideis americana (Ostracoda) from the northern Neotropics were investigated in order to understand site specific influences on the isotopic composition of their valves (δ 18 O, δ 13 C) in comparison to their host water and to connect this to morphological features of their valves (valve size, nodosity). C. salebrosa was found in a stream (Shell Creek, Florida) and a slightly brackish lake (Laguna del Rincon, Dominican Republic; salinity <0.7 psu) while C. americana occurred in a coastal lake with polyhaline waters (Parrotee Pond, Jamaica; salinity: >20 psu). Valve size and position of nodes differed between the two species. A reverse temperature dependency have been considered to influence Shell length (seasonally in Shell Creek, summer: 1076 µm; winter: 1092 µm, supposedly permanently in Laguna del Rincon, 1035 µm). But, regarding the small dataset other factors could not be excluded to influence ostracod valve size. A decline of node frequency of C. salebrosa is mainly related to an increase in salinity. Isotopic values of ostracod valves reflect the trend in stable isotopes of their host water. Variations in Cyprideis salebrosa δ 18 O and δ 13 C values signify differences in their host water. Offsets of ostracod valves to a theoretical calcite precipitated in their host water with an uncertain time lag (+0.015 to +2.63 ‰) needs to be clarified. This study presents a contribution to the understanding of environmental influences on modern ostracod shell characters as basis for paleontological applications.

Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

USGS Publications Warehouse

Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

1998-01-01

La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

Impact of Hot Spring Resort Development on the Groundwater Discharge in the Southeast Part of Laguna De Bay, Luzon, Philippines

NASA Astrophysics Data System (ADS)

Siringan, F. P.; Lloren, R. B.; Mancenido, D. L. O.; Jago-on, K. A. B.; Pena, M. A. Z.; Balangue-Tarriela, M. I. R.; Taniguchi, M.

2014-12-01

Direct groundwater seepage in a lake (DGSL) can be a major component to its water and nutrient budget. Groundwater extraction around a lake may affect the DGSL, thus it can be expected that it would also impact the lake. In the Philippines, Laguna de Bay which is the second largest freshwater lake in South-east Asia and used primarily for fisheries, is under significant water development pressure. Along the southern coast of the lake, in the Calamba-Los Banos area, rapid urbanization and development of the water resort industry, including hot spring spas, are expected to have led to a rapid increase in groundwater extraction. This study aims to establish the effect of this development to the DGSL in this part of the lake. As a first step, we utilized towed electrical resistivity (ER) profiling to identify and map the potential and type of groundwater seepage off the southern coast of the lake. SRTM digital elevation models and synthetic aperture radar images were used to delineate lineaments which are potential fractures that cut across the study area. ER profiles indicate widespread occurrence of GDL across the shallower parts of the lake. In the more offshore, deeper parts of the lake, DGSL appears to be more limited possibly due to more muddy sediments there. However, in this area, narrow, vertical high resistivity columns cut through the lake floor suggesting more discrete GDLs possibly controlled by faults.

Local climate change induced by groundwater overexploitation in a high Andean arid watershed, Laguna Lagunillas basin, northern Chile

NASA Astrophysics Data System (ADS)

Scheihing, Konstantin; Tröger, Uwe

2018-05-01

The Laguna Lagunillas basin in the arid Andes of northern Chile exhibits a shallow aquifer and is exposed to extreme air temperature variations from 20 to -25 °C. Between 1991 and 2012, groundwater levels in the Pampa Lagunillas aquifer fell from near-surface to 15 m below ground level (bgl) due to severe overexploitation. In the same period, local mean monthly minimum temperatures started a declining trend, dropping by 3-8 °C relative to a nearby reference station. Meanwhile, mean monthly maximum summer temperatures shifted abruptly upwards by 2.7 °C on average in around 1996. The observed air temperature downturns and upturns are in accordance with detected anomalies in land-surface temperature imagery. Two major factors may be causing the local climate change. One is related to a water-table decline below the evaporative energy potential extinction depth of 2 m bgl, which causes an up-heating of the bare soil surface and, in turn, influences the lower atmosphere. At the same time, the removal of near-surface groundwater reduces the thermal conductivity of the upper sedimentary layer, which consequently diminishes the heat exchange between the aquifer (constant heat source of 10 °C) and the lower atmosphere during nights, leading to a severe dropping of minimum air temperatures. The observed critical water-level drawdown was 2-3 m bgl. Future and existing water-production projects in arid high Andean basins with shallow groundwater should avoid a decline of near-surface groundwater below 2 m bgl and take groundwater-climate interactions into account when identifying and monitoring potential environmental impacts.

Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur

NASA Astrophysics Data System (ADS)

Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

1987-05-01

Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( λ = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

Microbial Diversity in Sediment Ecosystems (Evaporites Domes, Microbial Mats, and Crusts) of Hypersaline Laguna Tebenquiche, Salar de Atacama, Chile.

PubMed

Fernandez, Ana B; Rasuk, Maria C; Visscher, Pieter T; Contreras, Manuel; Novoa, Fernando; Poire, Daniel G; Patterson, Molly M; Ventosa, Antonio; Farias, Maria E

2016-01-01

We combined nucleic acid-based molecular methods, biogeochemical measurements, and physicochemical characteristics to investigate microbial sedimentary ecosystems of Laguna Tebenquiche, Atacama Desert, Chile. Molecular diversity, and biogeochemistry of hypersaline microbial mats, rhizome-associated concretions, and an endoevaporite were compared with: The V4 hypervariable region of the 16S rRNA gene was amplified by pyrosequencing to analyze the total microbial diversity (i.e., bacteria and archaea) in bulk samples, and in addition, in detail on a millimeter scale in one microbial mat and in one evaporite. Archaea were more abundant than bacteria. Euryarchaeota was one of the most abundant phyla in all samples, and particularly dominant (97% of total diversity) in the most lithified ecosystem, the evaporite. Most of the euryarchaeal OTUs could be assigned to the class Halobacteria or anaerobic and methanogenic archaea. Planctomycetes potentially also play a key role in mats and rhizome-associated concretions, notably the aerobic organoheterotroph members of the class Phycisphaerae. In addition to cyanobacteria, members of Chromatiales and possibly the candidate family Chlorotrichaceae contributed to photosynthetic carbon fixation. Other abundant uncultured taxa such as the candidate division MSBL1, the uncultured MBGB, and the phylum Acetothermia potentially play an important metabolic role in these ecosystems. Lithifying microbial mats contained calcium carbonate precipitates, whereas endoevoporites consisted of gypsum, and halite. Biogeochemical measurements revealed that based on depth profiles of O2 and sulfide, metabolic activities were much higher in the non-lithifying mat (peaking in the least lithified systems) than in lithifying mats with the lowest activity in endoevaporites. This trend in decreasing microbial activity reflects the increase in salinity, which may play an important role in the biodiversity.

Microbial Diversity in Sediment Ecosystems (Evaporites Domes, Microbial Mats, and Crusts) of Hypersaline Laguna Tebenquiche, Salar de Atacama, Chile

PubMed Central

Fernandez, Ana B.; Rasuk, Maria C.; Visscher, Pieter T.; Contreras, Manuel; Novoa, Fernando; Poire, Daniel G.; Patterson, Molly M.; Ventosa, Antonio; Farias, Maria E.

2016-01-01

We combined nucleic acid-based molecular methods, biogeochemical measurements, and physicochemical characteristics to investigate microbial sedimentary ecosystems of Laguna Tebenquiche, Atacama Desert, Chile. Molecular diversity, and biogeochemistry of hypersaline microbial mats, rhizome-associated concretions, and an endoevaporite were compared with: The V4 hypervariable region of the 16S rRNA gene was amplified by pyrosequencing to analyze the total microbial diversity (i.e., bacteria and archaea) in bulk samples, and in addition, in detail on a millimeter scale in one microbial mat and in one evaporite. Archaea were more abundant than bacteria. Euryarchaeota was one of the most abundant phyla in all samples, and particularly dominant (97% of total diversity) in the most lithified ecosystem, the evaporite. Most of the euryarchaeal OTUs could be assigned to the class Halobacteria or anaerobic and methanogenic archaea. Planctomycetes potentially also play a key role in mats and rhizome-associated concretions, notably the aerobic organoheterotroph members of the class Phycisphaerae. In addition to cyanobacteria, members of Chromatiales and possibly the candidate family Chlorotrichaceae contributed to photosynthetic carbon fixation. Other abundant uncultured taxa such as the candidate division MSBL1, the uncultured MBGB, and the phylum Acetothermia potentially play an important metabolic role in these ecosystems. Lithifying microbial mats contained calcium carbonate precipitates, whereas endoevoporites consisted of gypsum, and halite. Biogeochemical measurements revealed that based on depth profiles of O2 and sulfide, metabolic activities were much higher in the non-lithifying mat (peaking in the least lithified systems) than in lithifying mats with the lowest activity in endoevaporites. This trend in decreasing microbial activity reflects the increase in salinity, which may play an important role in the biodiversity. PMID:27597845

Espectroscopia del Cometa Halley

NASA Astrophysics Data System (ADS)

Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.

1987-05-01

Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

High plant diversity in Eocene South America: Evidence from Patagonia

USGS Publications Warehouse

Wilf, P.; Cuneo, N.R.; Johnson, K.R.; Hicks, J.F.; Wing, S.L.; Obradovich, J.D.

2003-01-01

Tropical South America has the highest plant diversity of any region today, but this richness is usually characterized as a geologically recent development (Neogene or Pleistocene). From caldera-lake beds exposed at Laguna del Hunco in Patagonia, Argentina, paleolatitude ~47oS, we report 102 leaf species. Radioisotopic and paleomagnetic analyses indicate that the flora was deposited 52 million years ago, the time of the early Eocene climatic optimum, when tropical plant taxa and warm, equable climates reached middle latitudes of both hemispheres. Adjusted for sample size, observed richness exceeds that of any other Eocene leaf flora, supporting an ancient history of high plant diversity in warm areas of South America.

Plasma Cholinesterase Activity in Female Green Turtles Chelonia mydas Nesting in Laguna de Terminos, Mexico Related to Organochlorine Pesticides in Their Eggs.

PubMed

Rivas-Hernández, Gerardo; May-Uc, Yaneli; Noreña-Barroso, Elsa; Cobos-Gasca, Víctor; Rodríguez-Fuentes, Gabriela

2018-01-01

The inhibition of cholinesterase (ChE) activity has been used as a biomarker of exposure to organophosphate and carbamate insecticides. ChE of nesting female green turtles (Chelonia mydas) were biochemically characterized using two substrates, acetylthiocholine iodide and butyrylthiocholine iodide, and three ChE inhibitors (eserine sulfate, BW284C51 and iso-OMPA). The results indicated that BChE is the predominant plasma ChE in female C. mydas, but with atypical properties that differ from those found in human BChE. Eggs from green turtles nesting at two sites in Laguna de Terminos contained µg g -1 (wet weight) quantities of organochlorine (OC) pesticides. Drins (aldrin, dieldrin, endrin, endrin ketone, endrin aldehyde) were found at the highest concentrations with no significant differences in the concentrations in eggs collected at the two sampling sites. A negative relationship was found between levels of OC pesticides in eggs and BChE activity in the plasma of female turtles laying the eggs. Since OC pesticides are not cholinesterase inhibitors, we hypothesized that this inverse relationship may be related to an antagonistic effect between OCs and organophosphate pesticides and mobilization of OCs from the fatty tissues of the female turtles into their eggs. However, further study is required to verify the hypothesis. It is also possible that other contaminants, such as petroleum hydrocarbons are responsible for the modulation of cholinesterase activity in female turtles.

Tdp studies and tests for C. A. Energia Electrica de Venezuela (enelven) at planta ramon laguna, units RL-17 and RL-10. Volume 1. Executive summary, RL-17 test report, and gas conversion proposals. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-03-28

The study, conducted by Babcock and Wilcox, was funded by the U.S. Trade and Development agency on behalf of Enelven. In order to maximize generated power output and minimize operating costs at Planta Ramon Laguna, tests were done to evaluate the condition of equipment at the plant. In order to identify any damage and determine the operating output of each unit, assessments were done of the furnaces, boilers, generators and boiler feed pumps being used in the plant. The report presents the results of these tests. This is the first of three volumes and it is divided into the followingmore » sections: (1) Executive Summary; (2) Hydrogen Damage Assessment; (3) RL-17 Gas Conversion Proposal; (4) RL-10 and RL-11 Gas Conversion Proposals.« less

Foraging behavior of redheads (Aythya americana) wintering in Texas and Louisiana

USGS Publications Warehouse

Woodin, M.C.; Michot, T.C.

2006-01-01

Redheads, Aythya americana, concentrate in large numbers annually in traditional wintering areas along the western and northern rim of the Gulf of Mexico. Two of these areas are the Laguna Madre of Texas and Chandeleur Sound of Louisiana. We collected data on 54,340 activities from 103 redhead flocks in Texas and 51,650 activities from 57 redhead flocks in Louisiana. Males and females fed similarly, differing neither in levels of feeding (percent of all birds in flock that were feeding) (p>0.90) nor in percentages of birds feeding by diving, tipping, dipping, or gleaning from the surface (p>0.10). The foraging level of redheads in the upper Laguna Madre region was relatively constant throughout two winters. Foraging of redheads in early winter in Louisiana was significantly greater than redhead foraging in the upper Laguna Madre, but by late winter, foraging by redheads in Louisiana had declined to the same level as that shown by redheads foraging in the upper Laguna Madre. The overall foraging level of redheads from Chandeleur Sound was greater (41%) than that of redheads in the upper Laguna Madre (26%), yet it was quite similar to the 46% foraging level reported for redheads from the lower Laguna Madre. Redheads in the upper Laguna Madre region of Texas fed more by diving than did those in the Chandeleur Sound and the lower Laguna Madre. Diving increased in frequency in late winter. Greater reliance by redheads on diving in January and February indicates that the birds altered their foraging to feed in deeper water, suggesting that the large concentrations of redheads staging at this time for spring migration may have displaced some birds to alternative foraging sites. Our results imply that the most likely period for food resources to become limiting for wintering redheads is when they are staging in late winter. ?? Springer 2006.

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

ERIC Educational Resources Information Center

LaGreca, Nancy

2012-01-01

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

Acoustic Response and Detection of Marine Mammals Using an Advanced Digital Acoustic Recording Tag(Rev 3)

DTIC Science & Technology

2007-03-13

Victor Gonzalez, University of La Laguna. Fieldwork was supported by University of La Laguna and Governments of El Hierro and the Canary Islands...team in El Hierro and the Field team in Liguria. Fieldwork support was provided by Universidad de La Laguna (ULL), BluWest, NATO Undersea Research...Center (NURC), and Governments of El Hierro and the Canary Islands. Some of Peter Madsen’s work was supported by a Steno Fellowship from the

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marina Del Rey, CA. 80.1118...

33 CFR 80.1118 - Marina Del Rey, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del Rey... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marina Del Rey, CA. 80.1118...

Manual del McVCO 1999

USGS Publications Warehouse

McChesney, P.J.

1999-01-01

El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

Rio San Jose Action Memo

EPA Pesticide Factsheets

This memorandum requests approval for a time-critical removal action at the II residential properties that compose the Rio San Jose Radiation Site located in Laguna, Mesita, Paraje, and Seama, Pueblo of Laguna located in Cibola County, New Mexico.

Ácaros del mango

USDA-ARS?s Scientific Manuscript database

Los ácaros constituyen un grupo abundante y diverso que ocupa diferentes hábitats en árboles frutales y la estructura y disposición del follaje y ramas del mango, contribuyen significativamente a que se presente gran diversidad de ácaros benéficos y dañinos asociados a esta especie frutal. En Colomb...

Torres del Paine National Park

NASA Image and Video Library

2017-12-08

Grinding glaciers and granite peaks mingle in Chile’s Torres del Paine National Park. The Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite captured this summertime image of the park on January 21, 2013. This image shows just a portion of the park, including Grey Glacier and the mountain range of Cordillera del Paine. The rivers of glacial ice in Torres del Paine National Park grind over bedrock, turning some of that rock to dust. Many of the glaciers terminate in freshwater lakes, which are rich with glacial flour that colors them brown to turquoise. Skinny rivers connect some of the lakes to each other (image upper and lower right). Cordillera del Paine rises between some of the wide glacial valleys. The compact mountain range is a combination of soaring peaks and small glaciers, most notably the Torres del Paine (Towers of Paine), three closely spaced peaks emblematic of the mountain range and the larger park. By human standards, the mountains of Cordillera del Paine are quite old. But compared to the Rocky Mountains (70 million years old), and the Appalachians (about 480 million years), the Cordillera del Paine are very young—only about 12 million years old. A study published in 2008 described how scientists used zircon crystals to estimate the age of Cordillera del Paine. The authors concluded that the mountain range was built in three pulses, creating a granite laccolith, or dome-shaped feature, more than 2,000 meters (7,000 feet) thick. NASA Earth Observatory image created by Jesse Allen and Robert Simmon, using Advanced Land Imager data from the NASA EO-1 team. Caption by Michon Scott. Instrument: EO-1 - ALI View more info: earthobservatory.nasa.gov/IOTD/view.php?id=80266 Credit: NASA Earth Observatory NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA�

A remote sensing assessment of the impact of the 2010 Maule, Chile earthquake (Mw 8.8) on the volcanoes of the southern Andes

NASA Astrophysics Data System (ADS)

Pritchard, M. E.; Welch, M.; Jay, J.; Button, N.

2011-12-01

del Maule and Cordón Caulle (which began a major eruption in June, 2011). The deformation rate at Laguna del Maule continues through 2011 at a similar high rate, accumulating more than 60 cm of vertical deformation since 2007 -- making it one of the largest deformation signals without recent eruption yet observed. The rate of uplift at Laguna del Maule seems to be unchanged before and after the 2010 Maule earthquake. The spatial and temporal deformation at Cordón Caulle is complex as noted by Fournier et al., 2010, but does not appear to have been changed by the Maule earthquake either. The reasons that the 2010 Maule earthquake did not strongly affect the closest volcanic arc in the southern Andes remains a mystery. Comparison with the 2004 Sumatra (Mw 9.2) and the 2011 Japan (Mw 9.0) earthquakes and their closest volcanic arcs could provide clues to the elusive links between large earthquakes and volcanic unrest.

76 FR 5196 - Aransas National Wildlife Refuge Complex, Aransas, Calhoun, and Refugio Counties, TX; Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... recreational development, the protection of natural resources, and the conservation of endangered or threatened.... We completed a thorough analysis of impacts on the human environment, which we included in the EA.../STRC/laguna/Index_Laguna.html . At the following libraries: Library Address Phone number Victoria...

Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR.

PubMed

Donaldson, Scott H; Pilewski, Joseph M; Griese, Matthias; Cooke, Jon; Viswanathan, Lakshmi; Tullis, Elizabeth; Davies, Jane C; Lekstrom-Himes, Julie A; Wang, Linda T

2018-01-15

Tezacaftor (formerly VX-661) is an investigational small molecule that improves processing and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro, and improves CFTR function alone and in combination with ivacaftor. To evaluate the safety and efficacy of tezacaftor monotherapy and of tezacaftor/ivacaftor combination therapy in subjects with cystic fibrosis homozygous for F508del or compound heterozygous for F508del and G551D. This was a randomized, placebo-controlled, double-blind, multicenter, phase 2 study (NCT01531673). Subjects homozygous for F508del received tezacaftor (10 to 150 mg) every day alone or in combination with ivacaftor (150 mg every 12 h) in a dose escalation phase, as well as in a dosage regimen testing phase. Subjects compound heterozygous for F508del and G551D, taking physician-prescribed ivacaftor, received tezacaftor (100 mg every day). Primary endpoints were safety through Day 56 and change in sweat chloride from baseline through Day 28. Secondary endpoints included change in percent predicted FEV 1 (ppFEV 1 ) from baseline through Day 28 and pharmacokinetics. The incidence of adverse events was similar across treatment arms. Tezacaftor (100 mg every day)/ivacaftor (150 mg every 12 h) resulted in a 6.04 mmol/L decrease in sweat chloride and 3.75 percentage point increase in ppFEV 1 in subjects homozygous for F508del, and a 7.02 mmol/L decrease in sweat chloride and 4.60 percentage point increase in ppFEV 1 in subjects compound heterozygous for F508del and G551D from baseline through Day 28 (P < 0.05 for all). These results support continued clinical development of tezacaftor (100 mg every day) in combination with ivacaftor (150 mg every 12 h) in subjects with cystic fibrosis. Clinical trial registered with www.clinicaltrials.gov (NCT01531673).

Kurt Gödels Brünner Verwandte

NASA Astrophysics Data System (ADS)

Müller, Dora

2007-11-01

The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

The novel c.247_249delTTC (p.F83del) GJB2 mutation in a family with prelingual sensorineural deafness.

PubMed

Petersen, Michael B; Grigoriadou, Maria; Koutroumpe, Maria; Kokotas, Haris

2012-07-01

Non-syndromic hearing loss is one of the most common hereditary determined diseases in human, and the disease is a genetically heterogeneous disorder. Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of non-syndromic recessive hearing impairment in many countries and are largely dependent on ethnic groups. Due to the high frequency of the c.35delG GJB2 mutation in the Greek population, we have previously suggested that Greek patients with sensorineural, non-syndromic deafness should be tested for the c.35delG mutation and the coding region of the GJB2 gene should be sequenced in c.35delG heterozygotes. Here we present on the clinical and molecular genetic evaluation of a family suffering from prelingual, sensorineural, non-syndromic deafness. A novel c.247_249delTTC (p.F83del) GJB2 mutation was detected in compound heterozygosity with the c.35delG GJB2 mutation in the proband and was later confirmed in the father, while the mother was homozygous for the c.35delG GJB2 mutation. We conclude that compound heterozygosity of the novel c.247_249delTTC (p.F83del) and the c.35delG mutations in the GJB2 gene was the cause of deafness in the proband and his father. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Estudio del CH interestelar

NASA Astrophysics Data System (ADS)

Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

Status of soil-transmitted helminth infections in schoolchildren in Laguna Province, the Philippines: Determined by parasitological and molecular diagnostic techniques.

PubMed

Mationg, Mary Lorraine S; Gordon, Catherine A; Tallo, Veronica L; Olveda, Remigio M; Alday, Portia P; Reñosa, Mark Donald C; Bieri, Franziska A; Williams, Gail M; Clements, Archie C A; Steinmann, Peter; Halton, Kate; Li, Yuesheng; McManus, Donald P; Gray, Darren J

2017-11-01

Soil-transmitted helminths (STH) are the most common parasitic infections in impoverished communities, particularly among children. Current STH control is through school-based mass drug administration (MDA), which in the Philippines is done twice annually. As expected, MDA has decreased the intensity and prevalence of STH over time. As a result, the common Kato Katz (KK) thick smear method of detecting STH is less effective because it lacks sensitivity in low intensity infections, making it difficult to measure the impact of deworming programs. A cross-sectional study was carried out over a four-week period from October 27, 2014 until November 20, 2014 in Laguna province, the Philippines. Stool samples were collected from 263 schoolchildren, to determine the prevalence of STH and compare diagnostic accuracy of multiplex quantitative polymerase chain reaction (qPCR) with the KK. A large discrepancy in the prevalence between the two techniques was noted for the detection of at least one type of STH infection (33.8% by KK vs. 78.3% by qPCR), Ascaris lumbricoides (20.5% by KK vs. 60.8% by qPCR) and Trichuris trichiura (23.6% by KK vs. 38.8% by qPCR). Considering the combined results of both methods, the prevalence of at least one type of helminth infection, A. lumbricoides, and T. trichiura were 83.3%, 67.7%, and 53.6%, respectively. Sensitivity of the qPCR for detecting at least one type of STH infection, A. lumbricoides, and T. trichiura were 94.1%, 89.9%, and 72.3% respectively; whereas KK sensitivity was 40.6%, 30.3%, and 44.0%, respectively. The qPCR method also detected infections with Ancylostoma spp. (4.6%), Necator americanus (2.3%), and Strongyloides stercoralis (0.8%) that were missed by KK. qPCR may provide new and important diagnostic information to improve assessment of the effectiveness and impact of integrated control strategies particularly in areas where large-scale STH control has led to low prevalence and/or intensity of infection.

Rock-magnetic proxies of wind intensity and dust since 51,200 cal BP from lacustrine sediments of Laguna Potrok Aike, southeastern Patagonia

NASA Astrophysics Data System (ADS)

Lisé-Pronovost, Agathe; St-Onge, Guillaume; Gogorza, Claudia; Haberzettl, Torsten; Jouve, Guillaume; Francus, Pierre; Ohlendorf, Christian; Gebhardt, Catalina; Zolitschka, Bernd

2015-02-01

The sedimentary archive from Laguna Potrok Aike is the only continuous record reaching back to the last Glacial period in continental southeastern Patagonia. Located in the path of the Southern Hemisphere westerly winds and in the source region of dust deposited in Antarctica during Glacial periods, southern Patagonia is a vantage point to reconstruct past changes in aeolian activity. Here we use high-resolution rock-magnetic and physical grain size data from site 2 of the International Continental scientific Drilling Program (ICDP) Potrok Aike maar lake Sediment Archive Drilling prOject (PASADO) in order to develop magnetic proxies of dust and wind intensity at 52°S since 51,200 cal BP. Rock-magnetic analysis indicates the magnetic mineral assemblage is dominated by detrital magnetite. Based on the estimated flux of magnetite to the lake and comparison with distal dust records from the Southern Ocean and Antarctica, kLF is interpreted as a dust indicator in the dust source of southern Patagonia at the millennial time scale, when ferrimagnetic grain size and coercivity influence are minimal. Comparison to physical grain-size data indicates that the median destructive field of isothermal remanent magnetization (MDFIRM) mostly reflects medium to coarse magnetite bearing silts typically transported by winds for short-term suspension. Comparison with wind-intensity proxies from the Southern Hemisphere during the last Glacial period and with regional records from Patagonia since the last deglaciation including marine, lacustrine and peat bog sediments as well as speleothems reveals similar variability with MDFIRM up to the centennial time scale. MDFIRM is interpreted as a wind-intensity proxy independent of moisture changes for southeastern Patagonia, with stronger winds capable of transporting coarser magnetite bearing silts to the lake.

Características del viento en estrellas Be derivadas del perfil Hα

NASA Astrophysics Data System (ADS)

Rohrmann, R.; Cidale, L.

El estudio teórico de perfiles Hα y su variabilidad en estrellas Be ha sido frecuentemente desarrollado en base a modelos de envolturas circunestelares inhomogéneas, donde la geometría del material es responsable de la forma del perfil dependiendo de la dirección de observación. Nosotros damos una interpretación alternativa y proponemos que la mayoría de las propiedades de esta línea tienen origen en la base de un viento estelar y de una estructura cromosférica anexa a la fotósfera. Encontramos que típicos perfiles Hα en Be, como son los llamados pole-on y winebottle, pueden ser reproducidos cualitativamente sin recurrir a la existencia de una envoltura asimétrica. Analizamos como la línea Hα permite identificar la posible estructura del viento en la región donde éste se inicia.

Tierra del Fuego, Argentina, South America

NASA Technical Reports Server (NTRS)

1991-01-01

The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

Earth observation taken by the Expedition 35 crew

NASA Image and Video Library

2013-04-20

ISS035-E-025019 (20 April 2013) --- One of the Expedition 35 crew members aboard the Earth-orbiting International Space Station used a 400 millimeter lens to record this photograph highlighting water of different color within sub basins of the Laguna (lake) Verde in the high Andes of northwest Argentina. The lake floor as a local low point lies at 4095 meters (13,438 feet) above sea level, whereas the peak of the local volcano west of the lake (not shown) reaches almost 3000 meters higher (or about 6818 meters, 22,368 feet). Laguna Verde (58 kilo meters wide, 36 kilometers long) often appears green, giving rise to its formal name. The image shows the turquoise tint in the central sub basin (image center), with a yellow to black tinge to water in the southern sub basin at image left (also known locally as Laguna Negra). The northernmost basin at image right appears quite black, and the large gray zone comprising much of the rest of Laguna Verde is likely a combination of shallow water, only inches deep, and sunglint reflecting off the water surface. The reason for the color differences lays in the fact the many different families of salt-loving organisms occupy hypersaline lakes such as Laguna Verde. These appear as different colors ? often bright -- depending on the salinities and temperatures of each water body or sub basin. The rest of the lake floor is dry and appears white from the build-up of thick salt deposits. Parallel lines around the southern sub basin (Laguna Negro) indicate prior shorelines of this shrinking water body ? evaporation removes water but leaves ephemeral shorelines marked with white salt.

Unidades del paisaje de Puerto Rico: la influencia del clima, el substrato y la topografia

Treesearch

William Gould; Michael E. Jimenez; Gary Potts; Maya Quinones; Sebastian Martinuzzi

2008-01-01

El mapa de unidades del paisaje de Puerto Rico representa variaciones climaticas, topograficas y del substrato mediante la integracion de seis zonas climaticas (Ewel y Whitmore, 1973), seis substratos (Bawiec, 2001; USGS, 2005), cinco posiciones topograficas, o topoformas (Martinuzzi et al. 2007), y cuerpos de agua (USGS 2005). Los substratos representan el conjunto...

English Non-Uniformity: A Non-Adult Form of Ethnic English.

ERIC Educational Resources Information Center

Stout, Steven Owen

The paper examines interpretive aspects of English non-uniformity among fifth and sixth grade Native Americans at Laguna Elementary School, Laguna, New Mexico. Speaker assessments of instances of uninflected "be" are ordered to form an implicational scale. The variability in the students' assessment pattern is compared to previous inter-ethnic…

Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

NASA Astrophysics Data System (ADS)

Davila Montanez, Melissa

Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

Estudio teórico del CO2. Orbitales de valencia y del ``core''

NASA Astrophysics Data System (ADS)

Olalla Gutiérrez, E.

Hemos calculado las intensidades de las transiciones E1 a los miembros de las series de Rydberg con origen en los orbitales ``no enlazantes'' del dióxido de carbono, especie de conocida relevancia atmosférica. Se han computado, asimismo, los continuos de fotoionización correspondientes a los distintos canales de ionización, representándolos como densidad espectral de fuerza de oscilador frente a la energía del fotón incidente; mostramos los resultados df/dE para la fotoionización total de esta especie en el intervalo 15-60 eV. Todos los cálculos se han llevado a cabo mediante la formulación Molecular del Método de los Orbitales de Defecto Cuántico, MQDO [1,2]. La calidad de los resultados que presentamos se ha evaluado en base a la comparación con los datos, tanto experimentales como teóricos, disponibles en la bibliografía. El acuerdo encontrado es altamente satisfactorio

The Instituto de Astrofísica de Canarias: 30 years of Research and Communication in Astronomy.

NASA Astrophysics Data System (ADS)

Del Puerto, Carmen; Rodriguez, Nayra; Rosenberg, Alfred; Beckman, John Etienne

2015-08-01

1985 was a year of inauguration for the Instituto de Astrofísica de Canarias (IAC). In that year its two observatories, the Observatorio del Roque de los Muchachos, on the island of La Palma, (where its 10.4m optical-NIR telescope vies with the world´s major instruments), and the Observatorio del Teide, on the island of Tenerife, as well as its headquarters in La Laguna, Tenerife, were all inaugurated. This young institution has rapidly become the leading research centre for astronomy in Spain and achieved research standards at a European and world level. The 30th anniversary celebrations this year give an opportunity to maximize its already very active outreach programmes. In February two shows, featuring IAC researchers, and with astronomical themes, were shown in the main theatre of the city of La Laguna, and during the year further entertainment, collaborating with Canarian musicians and artists, is planned. Two exhibitions have been designed combining the anniversary with celebrations of the International Year of Light: “Listen to the Universe”, in Tenerife, and “Thirty Journeys around the Sun”, in La Palma, which will be open to the public for most of the year. A new outreach magazine “Parallaxes” will be launched by the IAC, in both paper and digital editions, and will complement the current blog, and news websites of the institute, as well as its communications on Facebook and Twitter. Among the activities being organized in Tenerife will be the formal naming of traffic circles with names of the telescopes at the Observatories. In conjunction with the municipal wine cellars of the local city of Tegueste a new Canarian wine produced by innovative methods and with an astronomical motif on its label, is to be launched during the year. All of these activities are in addition to the somewhat more routine productions of videos on the research lines of the IAC, including exoplanets, solar stellar, and interstellar physics, galaxies, and cosmology.

Visiting the Gödel universe.

PubMed

Grave, Frank; Buser, Michael

2008-01-01

Visualization of general relativity illustrates aspects of Einstein's insights into the curved nature of space and time to the expert as well as the layperson. One of the most interesting models which came up with Einstein's theory was developed by Kurt Gödel in 1949. The Gödel universe is a valid solution of Einstein's field equations, making it a possible physical description of our universe. It offers remarkable features like the existence of an optical horizon beyond which time travel is possible. Although we know that our universe is not a Gödel universe, it is interesting to visualize physical aspects of a world model resulting from a theory which is highly confirmed in scientific history. Standard techniques to adopt an egocentric point of view in a relativistic world model have shortcomings with respect to the time needed to render an image as well as difficulties in applying a direct illumination model. In this paper we want to face both issues to reduce the gap between common visualization standards and relativistic visualization. We will introduce two techniques to speed up recalculation of images by means of preprocessing and lookup tables and to increase image quality through a special optimization applicable to the Gödel universe. The first technique allows the physicist to understand the different effects of general relativity faster and better by generating images from existing datasets interactively. By using the intrinsic symmetries of Gödel's spacetime which are expressed by the Killing vector field, we are able to reduce the necessary calculations to simple cases using the second technique. This even makes it feasible to account for a direct illumination model during the rendering process. Although the presented methods are applied to Gödel's universe, they can also be extended to other manifolds, for example light propagation in moving dielectric media. Therefore, other areas of research can benefit from these generic improvements.

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).

NASA Astrophysics Data System (ADS)

Menéndez, J. M.; Martín, I.; Velasco, A. M.

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

U.S. Fish and Wildlife Service refuges and other nearby reserves in Southwestern Puerto Rico

Treesearch

Peter L. Weaver; Joseph J. Schwagerl

2009-01-01

The main purpose of this paper is to summarize information about the Cabo Rojo and Laguna Cartagena National Wildlife Refuges in southwestern Puerto Rico. The Cabo Rojo (Headquarters and Salinas tracts) and Laguna Cartagena (Lagoon and Tinaja tracts) occupy 1174 ha and are part of the 10 231-ha Caribbean system of nine refuges. Their major geologic and physiographic...

27 CFR 9.201 - Sloughhouse.

Code of Federal Regulations, 2012 CFR

2012-04-01

... estuary and Alta Mesa Road, on the western boundary of section 4, T5N, R7E. From the beginning point... Dorado and Sacramento-Amador County line to the County line's intersection with the Laguna estuary, 0.75...) 17.5 miles along the meandering Laguna estuary, crossing over the Sloughhouse map, and return to the...

27 CFR 9.201 - Sloughhouse.

Code of Federal Regulations, 2013 CFR

2013-04-01

... estuary and Alta Mesa Road, on the western boundary of section 4, T5N, R7E. From the beginning point... Dorado and Sacramento-Amador County line to the County line's intersection with the Laguna estuary, 0.75...) 17.5 miles along the meandering Laguna estuary, crossing over the Sloughhouse map, and return to the...

27 CFR 9.201 - Sloughhouse.

Code of Federal Regulations, 2014 CFR

2014-04-01

... estuary and Alta Mesa Road, on the western boundary of section 4, T5N, R7E. From the beginning point... Dorado and Sacramento-Amador County line to the County line's intersection with the Laguna estuary, 0.75...) 17.5 miles along the meandering Laguna estuary, crossing over the Sloughhouse map, and return to the...

Tdp studies and tests for C. A. Energia Electrica de Venezuela (enelven) at planta ramon laguna, units RL-17 and RL-10. Volume 3. Unit RL-10 turbine generator condition assessment report and units RL-10 and RL-11 boiler feed pump conditon assessment report. Export trade information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-03-28

The study, conducted by Babcock and Wilcox, was funded by the U.S. Trade and Development agency on behalf of Enelven. In order to maximize generated power output and minimize operating costs at Planta Ramon Laguna, tests were done to evaluate the condition of equipment at the plant. In order to identify any damage and determine the operating output of each unit, assessments were done of the furnaces, boilers, generators and boiler feed pumps being used in the plant. The report presents the results of these tests. This is the last of three volumes and it is divided into the followingmore » sections: (1) Condition Assessment of Unit RL-10 Turbine-Generator; (2) Condition Assessment of Unit RL-10 and RL-11 Boiler Feed Pumps.« less

Gödel universes in string theory

NASA Astrophysics Data System (ADS)

Barrow, John D.; Dabrowski, Mariusz P.

1998-11-01

We show that homogeneous Gödel spacetimes need not contain closed timelike curves in low-energy-effective string theories. We find exact solutions for the Gödel metric in string theory for the full O(α') action including both dilaton and axion fields. The results are valid for bosonic, heterotic and super-strings. To first order in the inverse string tension α', these solutions display a simple relation between the angular velocity of the Gödel universe, Ω, and the inverse string tension of the form α'=1/Ω2 in the absence of the axion field. The generalization of this relationship is also found when the axion field is present.

Occurrences of ikaite and pseudomorphs after ikaite in Patagonian lakes - crystal morphologies and stable isotope composition

NASA Astrophysics Data System (ADS)

Oehlerich, Markus; Mayr, Christoph; Griesshaber, Erika; Ohlendorf, Christian; Zolitschka, Bernd; Sánchez-Pastor, Nuria; Kremer, Barbara; Lücke, Andreas; Oeckler, Oliver; Schmahl, Wolfgang

2010-05-01

Ikaite (CaCO3•6H2O), a hydrated calcium carbonate mineral occasionally found in marine sediments, has so far rarely been reported from non-marine sites. Modern ikaite and calcitic pseudomorphs after ikaite were recently discovered in Patagonian Argentina at the polymictic lakes of Laguna Potrok Aike (51°57´S, 70°23´W) and Laguna Cháltel (49°57´S, 71°07´W), respectively. Both lakes are of volcanic origin and have phosphorous-rich, alkaline waters, but differ in altitude (790 m asl and 110 m asl for Laguna Cháltel and Laguna Potrok Aike, respectively) and water temperature. The aim of this study is (1) to investigate conditions for the formation of ikaite and its transformation to more stable, water-free carbonate pseudomorphs after ikaite and (2) to assess the potential of ikaite and calcite pseudomorphs after ikaite as a paleoenvironmental tool in freshwater lakes. Crystallographic, morphological and isotopic characteristics of the pseudomorphs were investigated. Ikaite crystals were found (in September 2008) primarily on aquatic macrophytes and cyanobacteria colonies at Laguna Potrok Aike. Ikaite crystals transformed quickly to calcite pseudomorphs after ikaite after recovery from the cool lake water (4°C). The crystal structure of ikaite was investigated with single crystal X-ray diffraction on samples that were permanently kept cold (in the lake water). At Laguna Cháltel calcite pseudomorphs after ikaite were discovered in littoral sediment cores from 25 m water depth. The mm-sized, porous, polycrystalline calcium carbonate aggregates from the 104 cm long sediment core of Laguna Cháltel are morphologically pseudomorphs after ikaite. SEM and XRD analyses highlight that these pseudomorphs consist of several µm-small calcite crystals in a calcitic matrix. The shape of these micro-crystals changes from rounded to fibrous with increasing sediment depth. Some specimens show casts of cyanobacteria trichomes. The oxygen isotopic composition of calcite

Calidad de Imagen del Telescopio UNAM212

NASA Astrophysics Data System (ADS)

Cobos, F. J.; Teiada de Vargas, C.

1987-05-01

El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

Conservacion de truchas del Pacifico

Treesearch

Brooke E. Penaluna

2016-01-01

La historia de las truchas del Pacífico, pertenecientes al género Oncorhynchus, es una historia muy interesante que se basa en la persistencia y diversificación de sus especies debido, en gran parte, al dinamismo propio que existe en su medio ambiente. Desde el oeste de Norteamérica, extendiéndose hasta el este de Asia, las truchas del Pacífico han experimentado la...

Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)

USGS Publications Warehouse

Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

1996-01-01

A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

Policy Options to Address Crucial Communication Gaps in the Incident Command System

DTIC Science & Technology

2012-09-01

California Department of Forestry and Fire Protection COML Communications Unit Leader COMT Communication Technician EBRPD East Bay Regional Parks...Laguna Fire 1970 - One of California’s Worst Wildfires.” Available at http://www.cccarto.com/cal_wildfire/laguna/fire.html, Accessed August 10, 2012...NIMS - The Evolution of the National Incident Management System.” Fire Rescue Magazine, August 2011. 15 compatibility, and department emergency

Nevado del Huila, Columbia

NASA Technical Reports Server (NTRS)

2007-01-01

Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

Calidad del aire interior en las escuelas

EPA Pesticide Factsheets

EPA ha desarrollado el Programa de Herramientas de Calidad del Aire Interior para las Escuelas para reducir la exposición a los contaminantes ambientales en las mismas a través de la adopción voluntaria de las prácticas para manejar la calidad del aire int

Thickness of Santa Fe Group sediments in the Espanola Basin south of Santa Fe, New Mexico, as estimated from aeromagnetic data

USGS Publications Warehouse

Phillips, Jeffrey D.; Grauch, V.J.S.

2004-01-01

In the southern Espa?ola basin south of Santa Fe, New Mexico, weakly magnetic Santa Fe Group sediments of Oligocene to Pleistocene age, which represent the primary aquifers for the region, are locally underlain by moderately to strongly magnetic igneous and volcaniclastic rocks of Oligocene age. Where this relationship exists, the thickness of Santa Fe Group sediments, and thus the maximum thickness of the aquifers, can be estimated from quantitative analysis of high-resolution aeromagnetic data. These thickness estimates provide guidance for characterizing the ground-water resources in between scattered water wells in this area of rapid urban development and declining water supplies. This report presents one such analysis based on the two-step extended Euler method for estimating depth to magnetic sources. The results show the general form of a north-trending synclinal basin located between the Cerrillos Hills and Eldorado with northward thickening of Santa Fe Group sediments. The increase in thickness is gradual from the erosional edge on the south to a U-shaped Santa Fe embayment hinge line, north of which sediments thicken much more dramatically. Along the north-south basin axis, Santa Fe Group sediments thicken from 300 feet (91 meters) at the hinge line near latitude 35o32'30'N to 2,000 feet (610 meters) at the Cerrillos Road interchange at Interstate 25, north of latitude 35o36'N. The depth analysis indicates that, superimposed on this general synclinal form, there are many local areas where the Santa Fe Group sediments may be thickened by a few hundred feet, presumably due to erosional relief on the underlying Oligocene volcanic and volcaniclastic rocks. Some larger areas of greater apparent thickening occur where the presence of magnetic rocks directly underlying the Santa Fe Group is uncertain. Where magnetic rocks are absent beneath the Santa Fe Group, the thickness cannot be estimated from the aeromagnetic data.

Environmental Impact Analysis Process. Preliminary Draft Environmental Impact Statement Construction and Operation of Space Launch Complex 7. Volume 2. Appendices

DTIC Science & Technology

1988-11-15

3 Sincerely, William H. Ehorn3Suerintenent United States Department of the Interior FISH AND WILDLIFE SERVICE LAGUNA NIGUEL FIELD OFFICE 24000 Avila...Road Laguna Niguel, California 92656 Ma’ 19, 1988 Department of the Air Force Headquarters Space Division (AFSC) Los Angeles Air Force Station P. 0...agricultural supply, and ground water recharge. In addition, all minor streams and tributaries in the central coastal region, including Honda Creek and Jalama

May Gödel's Ideas Be Addressed Philosophically?

NASA Astrophysics Data System (ADS)

Dokulil, Miloš

2007-11-01

Gödel emphasised philosophy as an important tool in science. Much less is known about his religious background. We should bear in mind that our evaluational perspective differs very much from the one in which Gödel lived. He was personally sure that there must be another existence after death-an afterlife (''of unlimited life span''). As a ''Baptized Lutheran'' he did not include ''Trinity'' in his creed. He was also certain that mind is separate from matter. This text tries to include Libet's ''readiness potential'' into the debate concerning the specificity of the mind. Neither Gödel's identification of materialism with mechanism nor his vision of the ''spirit'' are a viable solution of the problem.

Sleeping site preferences in Sapajus cay Illiger 1815 (Primates: Cebidae) in a disturbed fragment of the Upper Paraná Atlantic Forest, Rancho Laguna Blanca, Eastern Paraguay.

PubMed

Smith, Rebecca L; Hayes, Sarah E; Smith, Paul; Dickens, Jeremy K

2018-01-01

Wild primates can spend up to half of their lives sleeping, during which time they are subjected to many of the same selective pressures that they face when awake. Choosing an appropriate sleeping site can thus have important fitness consequences. We examined the sleeping site preferences of wild hooded capuchins (Sapajus cay) in a small degraded fragment of the Upper Paraná Atlantic Forest at Rancho Laguna Blanca (RLB) in eastern Paraguay. Sleeping trees and sites were identified during 5 months of field observations and their physical characteristics were compared to those of non-sleeping trees and sites. Capuchins preferred larger emergent trees with more main and forked branches, no lianas and denser undergrowth directly below. These were found in sites of more mature forest with fewer small trees, less liana coverage and denser undergrowth but more fruiting trees. The species composition of the sleeping sites differed from that of the non-sleeping sites and was dominated by Albizia niopoides (Mimosaceae) as well as Peltophorum dubium (Fabaceae) and Anadenanthera colubrina (Fabaceae). The capuchins were found to sleep most often in these three tree species: 69.23% in Albizia niopoides (Mimosaceae), 11.54% in Peltophorum dubium (Fabaceae) and 11.54% in Anadenanthera colubrina (Fabaceae). We found evidence for the predator avoidance, thermoregulatory, social contact and feeding site proximity hypotheses. We found no support for parasite avoidance, given the reuse of sites, although the small size of the forest fragment may have restricted this. Their preference for older-growth forest suggests that selective logging impacts hooded capuchins. However, their persistence in a disturbed fragment shows they are highly adaptable, providing support for the value of conservation and reforestation of even small fragments of the Paraguayan Upper Paraná Atlantic Forest.

Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico

PubMed Central

Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

2012-01-01

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

Geologic map of the Tetilla Peak Quadrangle, Santa Fe and Sandoval counties, New Mexico

USGS Publications Warehouse

Sawyer, D.A.; Shroba, R.R.; Minor, S.A.; Thompson, R.A.

2002-01-01

Fe Group, mainly along the western border, in the hanging wall of the La Bajada fault zone, but locally extending 2-3 km east under the Cerros del Rio volcanic field; (3) older Tertiary volcanic and sedimentary rocks (Abiquiu?, Espinaso, and Galisteo Formations); (4) intrusive rocks of the Cerrillos intrusive center that are roughly coeval with the Espinaso volcanic rocks; and (5) Mesozoic sedimentary rocks ranging in age from the Upper Triassic Chinle Formation to the Upper Cretaceous Mancos Shale.

Geochemistry of thermal fluids in NW Honduras: New perspectives for exploitation of geothermal areas in the southern Sula graben

NASA Astrophysics Data System (ADS)

Capaccioni, Bruno; Franco, Tassi; Alberto, Renzulli; Orlando, Vaselli; Marco, Menichetti; Salvatore, Inguaggiato

2014-06-01

The results of a geochemical survey on thermal waters and, for the first time for this site, gas discharges in five geothermal sites (Azacualpa "La Cueva", Río Ulua, Río Gualcarque, El Olivar and Laguna de Agua Caliente) in NW Honduras are here presented and discussed. El Olivar and Laguna de Agua Caliente, in the southern part of the Sula graben are very close to a Quaternary basaltic field, whereas Azacualpa "La Cueva", Río Ulua and Río Gualcarque, located to the southwest of the Yojoa Lake, direcly emerge from the Cretaceous limestone deposits. The measured temperatures range between 37.5 and 104.8 °C. "Mature", alkaline, Na-SO4 thermal waters discharge from Azacualpa "La Cueva", while those from El Olivar and Laguna de Agua Caliente are "immature" and show a Na-HCO3 composition. Chemical equilibria of waters and gases from the Azacualpa "La Cueva" thermal springs indicate temperatures ranging from 150 to 200 °C. Conversely, gas discharges from El Olivar and Laguna de Agua Caliente have attained a partial chemical equilibrium in the liquid phase at slightly higher temperatures (200-250 °C), although gas-gas faster reactions involving CO seem to be adjusted in an isothermally separated vapor phase. Unlike Azacualpa, SiO2 geothermometer at El Olivar and Laguna de Agua Caliente indicates equilibrium temperatures for the liquid phase much lower than those calculated for the gas phase (≤ 120 °C). We conclude that thermal waters from the Azacualpa area likely represent the direct emergence of a water dominated reservoir having temperatures ≤ 150-200 °C. By contrast, at El Olivar and Laguna de Agua Caliente hot springs are supplied by a boiling shallow aquifer fed by a vapor phase rising from a steam-dominated zone. The above geochemical model is consistent with a geothermal reservoir hosted within the Cretaceous carbonate sequences of the Yojoa Group in the whole investigated sites. The reservoir extensively crops out in the Azacualpa area whereas the

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing...

El Atlas del Bosque Nacional El Yunque

Treesearch

Maya Quiñones; Isabel K. Parés-Ramos; William A. Gould; Grizelle Gonzalez; Kathleen McGinley; Pedro. Ríos

2018-01-01

Esta publicación es un esfuerzo colaborativo entre el Instituto Internacional de Dasonomía Tropical y el Bosque Nacional El Yunque para proveer mapas y análisis de información espacial actualizados sobre una importante reserva natural en Puerto Rico y el único bosque tropical dentro del Sistema de Bosques Nacionales de los Estados Unidos. El Atlas del Bosque Nacional...

Wirelessly controlled micro- and nanostructures for bioapplications

NASA Astrophysics Data System (ADS)

Lindo, Andre Machado

Apresentar uma contribuicao para a caracterizacao e compreensao do comportamento hidrodinâmico da laguna Ria de Aveiro, baseada num estudo experimental e num estudo de modelacao numerica, e o objectivo deste trabalho. As caracteristicas hidrologicas da Ria de Aveiro foram investigadas atraves da realizacao de varias campanhas de amostragem, tendo sido efectuadas medicoes de altura de agua, salinidade, temperatura da agua e velocidade da corrente em varias estacoes distribuidas ao longo de quatro canais principais da laguna. None

Hydrologic characteristics of lagoons at San Juan, Puerto Rico, during an October 1974 tidal cycle

USGS Publications Warehouse

Gómez-Gómez, Fernando; Ellis, S.R.

1983-01-01

Flow and water-quality changes were studied during a period of intense rainfall in the San Juan Lagoon system. The study covered a 25-hour period beginning 0900 hours 22 October, 1974. Precipitation during the study period averaged 70 millimeters. Sampling stations were located at Boca de Cangrejos, the main ocean outlet; Canal Pinones between Laguna de Pinones and Laguna La Torrecilla; Canal Suarez between Laguna San Jose, connects to Laguna La Torrecilla; and Cano de Martin Pena between Laguna San Jose and Bahia de San Juan. In addition water-elevation recording gages were installed at each lagoon. Water samples from the canal stations were analyzed for organic carbon, nitrogen and phosphorus species, and suspended sediment. Specific-conductance measurements were used with the chemical data to estimate the runoff contributions of nutrients. Runoff into the lagoon, system during the study period was about 2.8 million cubic meters, or about 70 percent of the average precipitation. The runoff contributed chemical loadings to the lagoons of 95,000 kilograms total-organic carbon; 2,700 kilograms of total phosphorus; and 10,000 kilograms of total Khjeldhal nitrogen. A comparison with a prior study during which there was no significant rain, show that dry-period loadings are less than 10 percent of the wet-period loadings. At the end of the study period the system had not reached equilibrium, and the lagoons retained 80 percent of the water inflows from 50 to 90 percent of the chemical loads. Nearly 95 percent of the water outflows occurred at the Boca de Cangrejos sea outlet. The three lagoons and interconnecting canals form a very complex hydraulic system that is difficult to study using traditional techniques. A model of the system will facilitate management to improve the quality of water in the lagoons.

Just add water and the Colorado River still reaches the sea.

PubMed

Glenn, Edward P; Flessa, Karl W; Cohen, Michael J; Nagler, Pamela L; Rowell, Kirsten; Zamora-Arroyo, Francisco

2007-07-01

A recent article in Environmental Management by All argued that flood flows in North America's Colorado River do not reach the Gulf of California because they are captured and evaporated in Laguna Salada, a below sea-level lakebed near the mouth of the river. We refute this hypothesis by showing that (1) due to its limited area, the Laguna Salada could have evaporated less than 10% of the flood flows that have occurred since 1989; (2) low flow volumes preferentially flow to the Gulf rather than Laguna Salada; (3) All's method for detecting water surface area in the Laguna Salada appears to be flawed because Landsat Thematic Mapper images of the lakebed show it to be dry when All's analyses said it was flooded; (4) direct measurements of salinity at the mouth of the river and in the Upper Gulf of California during flood flows in 1993 and 1998 confirm that flood waters reach the sea; and (5) stable oxygen isotope signatures in clam shells and fish otoliths recorded the dilution of seawater with fresh water during the 1993 and 1998 flows. Furthermore, All's conclusion that freshwater flows do not benefit the ecology of the marine zone is incorrect because the peer-reviewed literature shows that postlarval larval shrimp populations increase during floods, and the subsequent year's shrimp harvest increases. Furthermore, freshwater flows increase the nursery area for Gulf corvina (Cynoscion othonopterus), an important commercial fish that requires estuarine habitats with salinities in the range of 26-38 per thousand during its natal stages. Although flood flows are now much diminished compared to the pre-dam era, they are still important to the remnant wetland and riparian habitats of the Colorado River delta and to organisms in the intertidal and marine zone. Only a small fraction of the flood flows are evaporated in Laguna Salada.

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

33 CFR 110.65 - Indian River Bay, Del.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence 354...

Del-1 Expression as a Potential Biomarker in Triple-Negative Early Breast Cancer.

PubMed

Lee, Soo Jung; Lee, Jeeyeon; Kim, Wan Wook; Jung, Jin Hyang; Park, Ho Yong; Park, Ji-Young; Chae, Yee Soo

2018-01-01

A differential diagnostic role for plasma Del-1 was proposed for early breast cancer (EBC) in our previous study. We examined tumoral Del-1 expression and analyzed its prognostic impact among patients with EBC. Del-1 mRNA expression was assessed in breast epithelial and cancer cells. Meanwhile, the tumoral expression of Del-1 was determined based on tissue microarrays and immunohistochemistry results from 440 patients. While a high Del-1 mRNA expression was found in all the breast cancer cell lines, the expression was significantly higher in MDA-MB-231. Tumoral expression of Del-1 was also significantly associated with a negative expression of estrogen receptor or progesterone receptor, and low expression of Ki-67, particularly in the case of triple-negative breast cancer (TNBC) (p < 0.036). Furthermore, a correlation was found between Del-1 expression and an aggressive histological grade, nuclear mitosis, and polymorphism, suggesting a possible role in tumor progression. In the survival analysis, a worse distant disease-free survival trend was noted for the group overexpressing Del-1. While all the investigated breast cancer cell lines exhibited Del-1 expression, the expression rate and intensity were specifically prominent in TNBC. In addition, based on its relationship to an unfavorable histology and worse survival trend, Del-1 could act as a molecular target in TNBC patients. © 2018 S. Karger AG, Basel.

Forensic applicability of multi-allelic InDels with mononucleotide homopolymer structures.

PubMed

Zhang, Shu; Zhu, Qiang; Chen, Xiaogang; Zhao, Yuancun; Zhao, Xiaohong; Yang, Yiwen; Gao, Zehua; Fang, Ting; Wang, Yufang; Zhang, Ji

2018-04-27

Insertion/deletion polymorphisms (InDels), which possess the characteristics of low mutation rates and a short amplicon size, have been regarded as promising markers for forensic DNA analysis. InDels can be classified as bi-allelic or multi-allelic, depending on the number of alleles. Many studies have explored the use of bi-allelic InDels in forensic applications, such as individual identification and ancestry inference. However, multi-allelic InDels have received relatively little attention. In this study, InDels with 2-6 alleles and a minor allele frequency ≥0.01, in Chinese Southern Han (CHS), were retrieved from the 1000 Genomes Project Phase III. Based on the structural analysis of all retrieved InDels, 17 multi-allelic markers with mononucleotide homopolymer structures were selected and combined in one multiplex PCR reaction system. Sensitivity, species specificity and applicability in forensic case work of the multiplex were analyzed. A total of 218 unrelated individuals from a Chinese Han population were genotyped. The combined discriminatory power (CDP), the combined match probability (CMP) and the cumulative probability of exclusion (CPE) were 0.9999999999609, 3.91E-13 and 0.9956, respectively. The results demonstrated that this InDel multiplex panel was highly informative in the investigated population and most of the 26 populations of the 1000 Genomes Project. The data also suggested that multi-allelic InDel markers with monomeric base pair expansions are useful for forensic applications. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The Nd-, Sr- and Pb-isotopic character of lavas from Taal, Laguna de Bay and Arayat volcanoes, southwestern Luzon, Philippines: Implications for arc magma petrogenesis

USGS Publications Warehouse

Mukasa, S.B.; Flower, M.F.J.; Miklius, Asta

1994-01-01

Following the amalgamation of a collage of pre-Neogene terranes largely by strike-slip and convergence mechanisms to form the Philippine islands, volcanic chains, related to oppositely dipping subduction zones, developed along the eastern and western margins of the archipelago. There is ample field evidence that this volcanic activity, predominantly calc-alkaline in chemical character, had commenced by the Oligocene. Volcanoes resulting from subduction along the Manila-Negros trench in the west (e.g. Taal, Laguna de Bay and Arayat) form a high-angle linear array, trending away from the MORE field on Pb-isotopic covariation diagrams; have the highest Sr- and lowest Nd-isotopic compositions, of the two chains (but nevertheless plotting above bulk earth on the 87Sr/86Sr versus 143Nd/144Nd covariation diagram); and exhibit Sm/Nd and Rb/Sr values that are lower and higher, respectively, than the estimated values for bulk earth. While the Sm/Nd and Rb/Sr characteristics are common to both chains, volcanoes associated with the Philippine-East Luzon trench have Pb-isotopic compositions that fall in the Indian Ocean MORB field and that require time-integrated evolution in a high Th/U environment. They also have higher Nd- and lower Sr-isotopic ratios. The source materials of Philippine volcanoes, therefore, have undergone varied recent enrichments in LILE, as indicated by the decoupling of isotopic and elemental ratios. These enrichments, particularly for the western volcanoes, cannot be entirely due to small degrees of partial melting in the mantle wedge, considering that they were accompanied by elevations in radiogenic Pb. Elevated Pb ratios are best explained by the introduction of subducted, continentally derived sediments. The sedimentary component in the western volcanoes is probably the South China Sea sediments derived largely from Eurasia. That this component is not available in the Philippine-East Luzon trench is reflected by the fact that the eastern volcanoes

A new species of Acanthobothrium (Eucestoda: Onchobothriidae) in Aetobatus cf. narinari (Myliobatidae) from Campeche, México.

PubMed

Rodríguez-Ibarra, Erick; Pulido-Flores, Griselda; Violante-González, Juan; Monks, Scott

2018-01-01

The helminthological examination of nine individuals of Aetobatus cf. narinari (spotted eagle ray; raya pinta; arraia pintada) revealed the presence of an undescribed species of cestode of the genus Acanthobothrium. The stingrays were collected from four locations in México: Laguna Términos, south of Isla del Carmen and the marine waters north of Isla del Carmen and Champotón, in the State of Campeche, and Isla Holbox, State of Quintana Roo. The new species, nominated Acanthobothrium marquesi, is a category 3 species (i.e, the strobila is long, has more than 50 proglottids, the numerous testicles greater than 80, and has asymmetrically-lobed ovaries); at the present, the only category 3 species that has been reported in the Western Atlantic Ocean is Acanthobothrium tortum. Acanthobothrium marquesi n. sp. can be distinguished from A. tortum by length (26.1 cm vs. 10.6 cm), greater number of proglottids (1,549 vs. 656), a larger scolex (707 µm long by 872 µm wide vs. 699 µm long by 665 µm wide), larger bothridia (626 µm long by 274 µm wide vs. 563 µm long by 238 µm wide). This is the first report of a species of Acanthobothrium from the Mexican coast of the Gulf México.

Design, aerodynamics and autonomy of the DelFly.

PubMed

de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

2012-06-01

One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor.

Mejoras en la exactitud del reloj de ángulo horario del telescopio de 2,15 mts de CASLEO

NASA Astrophysics Data System (ADS)

Aballay, J. L.; Pereyra, P. F.; Marún, A. H.

Para aumentar la exactitud en el control del ángulo horario del telescopio, se está implementando el uso de un reloj con una precisión de 1/100 seg. En conjunto con el encoder que otorga la posición con un acierto de 0,012 seg. de arco, se podrá implementar otro dígito en el reloj de ángulo horario con la posibilidad de ver las décimas. Esto, sumado a la precisión ya lograda en declinación, permitirá realizar offsets con mayor exactitud.

Case Study: del Amo Bioventing

EPA Science Inventory

The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

NASA Astrophysics Data System (ADS)

Ramos Pastrana, Nilsa

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la

An evaluation of Delaware's DelTrac program : building an integrated transportation management system

DOT National Transportation Integrated Search

2004-06-01

The DelTrac deployment experience included both successes and unmet challenges. Programmatically, the DelTrac approach to managing ITS has been successful at creating a great deal of integration and cooperation between organizations at DelDOT. Stakeh...

El uso de la neuromodulación para el tratamiento del temblor

PubMed Central

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

2014-01-01

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

CHEK2 1100delC and male breast cancer in the Netherlands.

PubMed

Wasielewski, Marijke; den Bakker, Michael A; van den Ouweland, Ans; Meijer-van Gelder, Marion E; Portengen, Henk; Klijn, Jan G M; Meijers-Heijboer, Hanne; Foekens, John A; Schutte, Mieke

2009-07-01

Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors for female breast cancer. Mutations in BRCA1 and BRCA2 also are associated with male breast cancer (MBC). Similarly, it had been suggested in the original CHEK2 identification report that the CHEK2 1100delC mutation confers an increased risk for MBC. Here, we have evaluated the risk of CHEK2 1100delC for MBC by genotyping CHEK2 1100delC in 23 familial and 71 unselected Dutch MBC cases. None of the 23 familial MBC cases carried the CHEK2 1100delC mutation. In contrast, CHEK2 1100delC was present in 3 of the 71 (4.2%) unselected MBC cases, which was significantly more prevalent than the 1.1% Dutch population frequency assessed in 1,692 individuals (P = 0.05, OR = 4.1, 95% CI 1.2-14.3). Our data suggest that, in the Netherlands, CHEK2 1100delC is associated with an increased risk for MBC.

Field measurements of del13C in ecosystem respiration

NASA Astrophysics Data System (ADS)

van Asperen, Hella; Sabbatini, Simone; Nicolini, Giacomo; Warneke, Thorsten; Papale, Dario; Notholt, Justus

2014-05-01

Stable carbon isotope del13C-measurements are extensively used to study ecological and biogeochemical processes in ecosystems. Above terrestrial ecosystems, atmospheric del13C can vary largely due to photosynthetic fractionation. Photosynthetic processes prefer the uptake of the lighter isotope 12C (in CO2), thereby enriching the atmosphere in 13C and depleting the ecosystem carbon. At night, when ecosystem respiratory fluxes are dominant, 13C-depleted CO2 is respired and thereby depletes the atmospheric del13C-content. Different ecosystems and different parts of one ecosystem (type of plant, leaves, and roots) fractionate and respire with a different del13C-ratio signature. By determining the del13C-signature of ecosystem respiration in temporal and spatial scale, an analysis can be made of the composition of respiratory sources of the ecosystem. A field study at a dry cropland after harvest (province of Viterbo, Lazio, Italy) was performed in the summer of 2013. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure CO2-, CH4-, N2O-, CO- and del13C-concentrations. The FTIR was connected to 2 different flux measurements systems: a Flux Gradient system (sampling every half hour at 1.3m and 4.2m) and 2 flux chambers (measured every hour), providing a continuous data set of the biosphere-atmosphere gas fluxes and of the gas concentrations at different heights. Keeling plot intercept values of respiratory CO2, measured by the Flux Gradient system at night, were determined to be between -25‰ and -20‰. Keeling plot intercept values of respiratory CO2, measured by the flux chamber system, varied between -24‰ and -29‰, and showed a clear diurnal pattern, suggesting different (dominant) respiratory processes between day and night.

[Strengths and future of the Revista Médica del Instituto Mexicano del Seguro Social].

PubMed

Fajardo-Dolci, Germán

2014-01-01

The journals of medicine arose as a communication tool more than 200 years ago. At the beginning, their nature was local; later, their aim was to spread medical information along the nation; and, finally, they sought to reach the world distribution. The Revista Médica del Instituto Mexicano del Seguro Social was published for the first time 52 years ago, and it has walked its way from local to international distribution. This journal has 23 000 subscribers, it is included in Medline and it reached a 0.112 SCImago Journal Rank in 2012. Its website receives around 200 000 visits monthly and 45 % are foreign visits. In the future, the peer review system is going to be strengthened, and the journal is going to offer audio, video, and applications to reinforce interactive participation between authors, readers in order to reach modernity and draw young new attention.

Observation of intensity of cosmic rays and daily magnetic shifts near meridian 70° in the South America

NASA Astrophysics Data System (ADS)

Cordaro, E. G.; Gálvez, D.; Laroze, D.

2016-05-01

In analysis of experiments carried during September 2008 using secondary cosmic ray detectors located in Chacaltaya (Bolivia) and Niteroi (Brazil), Augusto et al. (2010) showed an increase in the intensity of charged particles which takes place 3 h after sunrise and lasts until 1 h after sunset, furthermore they said that during this period the solar magnetic field lines overtake the Earth‧s surface. These stations are located within the South Atlantic Magnetic Anomaly (SAMA), having both different magnetic rigidities. To reproduce data from the Niteroi and Chacaltaya stations, we record data during the same hours and days using our neutron monitors, muon telescopes and magnetometers within the stations Putre and Los Cerrillos. Our observation stations in Putre and Cerrillos are located at 18°11‧47.8″S, 69°33‧10.9″W at an altitude of 3600 m and 33°29‧42.3″S, 70°42‧59.81″W with 570 m height above sea level, respectively. These stations are located within the South Atlantic Anomaly (SAMA) and are separated approximately 1700 km from each other and 1700 km from the center of the anomaly. Our network is composed furthermore by two auxiliary Cosmic Ray and/or Geomagnetic stations located at different latitudes along 70°W meridian, LARC and O'Higgins stations, which are located within Antarctic territory, covering a broad part of the Southern Hemisphere. Our magnetometer data shows that for each of the components, shifts in the magnetic field intensity for every station (even for those out of the SAMA) lasted between 3 and 4 h after sunrise and 1 and 2 h past sunset, which are the periods when the geomagnetic field is modulated by the transit of the dayside to nightside and nightside to dayside. We believe that, although the magnetometric data indicates the magnetic reconnection for the Chilean region, there is no direct influence from the SAMA other than the lower rigidity cut-off that leads to an increased count rate. Other details about the

Glaucoma diagnostic capacity of optic nerve head haemoglobin measures compared with spectral domain OCT and HRT III confocal tomography.

PubMed

Mendez-Hernandez, Carmen; Rodriguez-Uña, Ignacio; Gonzalez-de-la Rosa, Manuel; Arribas-Pardo, Paula; Garcia-Feijoo, Julian

2016-11-01

The computer program laguna onhe determines optic nerve head haemoglobin (ONH Hb) on retinal photographs based on detecting colour differences. This study compares the diagnostic capacity of Laguna ONhE with that of spectral domain optical coherence tomography (OCT) and confocal tomography (HRT III). In a prospective, observational, cross-sectional study, glaucomatous (n = 66) and healthy (n = 52) eyes were examined by Spectralis OCT, HRT III and Laguna ONhE. The following Laguna ONhE variables were determined: ONH Hb across the vertical disc diameter (8&20 Hb), estimated cup-disc ratio (C/D) and the glaucoma discriminant function (GDF), which combines the slope of Hb amount with the mean in 8&20 Hb. The three diagnostic methods were compared by calculating areas under ROC curves (AUCs). Correlations between variables were assessed through Spearman's rho coefficient. Areas under ROC curves (AUCs) were 0.785 (95% CI: 0.700-0.863) for GDF, 0.807 (95% CI: 0.730-0.883) for OCT retinal nerve fibre layer thickness (OCT-RNFL) and 0.714 (95% CI: 0.618-0.810) and 0.721 (95% CI: 0.628-0.815) for the HRT III variable GPS (glaucoma probability score) and vertical C/D ratio, respectively. Glaucoma discriminant function (GDF) was correlated with OCT-RNFL (0.587, p 0.001; 0.507, p 0.045; and -0.119, p 0.713 for mild, moderate and advanced glaucoma, respectively), mostly so with inferior OCT-RNFL (0.622; p < 0.001). Glaucoma discriminant function (GDF)-HRT III correlations were lower (rim area 0.471, p < 0.0001; rim/disc area 0.426, p < 0.0001; vertical C/D -0.413, p < 0.0001; GPS -0.408, p < 0.0001; rim volume 0.341, p < 0.0001). Similar diagnostic power was observed for Laguna ONhE, Spectralis OCT and HRT III. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

ERIC Educational Resources Information Center

Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

2007-01-01

Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization…

Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

PubMed Central

Musner, Nicolò; Sidoli, Mariapaola; Zambroni, Desireè; Del Carro, Ubaldo; Ungaro, Daniela; D’Antonio, Maurizio; Feltri, Maria L.

2016-01-01

In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates in the ER lumen and induces a demyelinating neuropathy in Charcot–Marie–Tooth disease type 1B (CMT1B)–S63del mice. Accumulation of P0S63del in the ER triggers a persistent unfolded protein response. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER stress sensor that phosphorylates eukaryotic initiation factor 2 alpha (eIF2alpha) in order to attenuate protein synthesis. We have shown that increasing phosphophorylated-eIF2alpha (P-eIF2alpha) is a potent therapeutic strategy, improving myelination and motor function in S63del mice. Here, we explore the converse experiment: Perk haploinsufficiency reduces P-eIF2alpha in S63del nerves as expected, but surprisingly, ameliorates, rather than worsens S63del neuropathy. Motor performance and myelin abnormalities improved in S63del//Perk+/− compared with S63del mice. These data suggest that mechanisms other than protein translation might be involved in CMT1B/S63del neuropathy. In addition, Perk deficiency in other cells may contribute to demyelination in a non–Schwann-cell autonomous manner. PMID:27095827

Multiplex pyrosequencing of InDel markers for forensic DNA analysis.

PubMed

Bus, Magdalena M; Karas, Ognjen; Allen, Marie

2016-12-01

The capillary electrophoresis (CE) technology is commonly used for fragment length separation of markers in forensic DNA analysis. In this study, pyrosequencing technology was used as an alternative and rapid tool for the analysis of biallelic InDel (insertion/deletion) markers for individual identification. The DNA typing is based on a subset of the InDel markers that are included in the Investigator ® DIPplex Kit, which are sequenced in a multiplex pyrosequencing analysis. To facilitate the analysis of degraded DNA, the polymerase chain reaction (PCR) fragments were kept short in the primer design. Samples from individuals of Swedish origin were genotyped using the pyrosequencing strategy and analysis of the Investigator ® DIPplex markers with CE. A comparison between the pyrosequencing and CE data revealed concordant results demonstrating a robust and correct genotyping by pyrosequencing. Using optimal marker combination and a directed dispensation strategy, five markers could be multiplexed and analyzed simultaneously. In this proof-of-principle study, we demonstrate that multiplex InDel pyrosequencing analysis is possible. However, further studies on degraded samples, lower DNA quantities, and mixtures will be required to fully optimize InDel analysis by pyrosequencing for forensic applications. Overall, although CE analysis is implemented in most forensic laboratories, multiplex InDel pyrosequencing offers a cost-effective alternative for some applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

[Trattamento del disturbo da uso di alcol da un punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; De Rosa, Francesca; Solombrino, Simona; Scalese, Bruna; Ciccarelli, Rosaria; Attilia, Fabio; Vitali, Mario; Musetti, Alessia; Fiore, Marco; Ceccanti, Mauro

2018-01-01

RIASSUNTO. L'elaborazione del piano di trattamento rappresenta un momento molto delicato e complesso del processo terapeutico del disturbo da abuso di alcol (DUA). È la fase in cui le informazioni raccolte da un'équipe di professionisti (medici, psicologi e assistenti sociali) (modello bio-psico-sociale del DUA) vengono messe insieme per decidere il percorso terapeutico più adatto. Per quanto riguarda la parte psicologica, è di notevole importanza scegliere un trattamento clinico in grado di ridurre al minimo la mancata adesione al trattamento e, per i soggetti che rimangono in trattamento, di garantirne l'efficacia. Se da una parte, le tecniche psicoanalitiche e comportamentali hanno fornito le basi della terapia psicologica dell'alcolismo, dall'altra, gli approcci basati sull'evidenza scientifica sono stati elaborati a partire dai principi del colloquio motivazionale e della terapia cognitivo-comportamentale. In questo articolo viene fornita una panoramica dei trattamenti che sono risultati più efficaci nel trattare il DUA e delle modalità temporali più adeguate per monitorare l'efficacia del trattamento.

Multi-InDel Analysis for Ancestry Inference of Sub-Populations in China

PubMed Central

Sun, Kuan; Ye, Yi; Luo, Tao; Hou, Yiping

2016-01-01

Ancestry inference is of great interest in diverse areas of scientific researches, including the forensic biology, medical genetics and anthropology. Various methods have been published for distinguishing populations. However, few reports refer to sub-populations (like ethnic groups) within Asian populations for the limitation of markers. Several InDel loci located very tightly in physical positions were treated as one marker by us, which is multi-InDel. The multi-InDel shows potential as Ancestry Inference Marker (AIM). In this study, we performed a genome-wide scan for multi-InDels as AIM. After examining the FST distributions in the 1000 Genomes Database, 12 candidates were selected and validated for eastern Asian populations. A multiplexed assay was developed as a panel to genotype 12 multi-InDel markers simultaneously. Ancestry component analysis with STRUCTURE and principal component analysis (PCA) were employed to estimate its capability for ancestry inference. Furthermore, ancestry assignments of trial individuals were conducted. It proved to be very effective when 210 samples from Han and Tibetan individuals in China were tested. The panel consisting of multi-InDel markers exhibited considerable potency in ancestry inference, and was suggested to be applied in forensic practices and genetic population studies. PMID:28004788

Observaciones del CH interestelar y el continuo en 3,3 GHz

NASA Astrophysics Data System (ADS)

Olano, C. A.; Combi, J. A.; Pöppel, W.; Benaglia, P.; Sanz, A. J.; Bava, J. A.

Se informa sobre el proyecto que se lleva a cabo en el IAR con el propósito de observar las líneas hiperfinas del estado fundamental del CH y el continuo en la banda de 3,3 GHz. El nuevo receptor construído en nuestro laboratorio para tal fin se instaló sobre uno de los radiotelescopios, funcionando conjuntamente con los sistemas de procesamiento actuales del IAR. Los resultados de las primeras observaciones, realizadas tanto en las líneas espectrales como en el continuo sobre fuentes conocidas, fueron satisfactorios.

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.

PubMed

Muranen, Taru A; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno; Pharoah, Paul D P; Dunning, Alison M; Shah, Mitul; Luben, Robert; Bojesen, Stig E; Nordestgaard, Børge G; Schoemaker, Minouk; Swerdlow, Anthony; García-Closas, Montserrat; Figueroa, Jonine; Dörk, Thilo; Bogdanova, Natalia V; Hall, Per; Li, Jingmei; Khusnutdinova, Elza; Bermisheva, Marina; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Investigators, Nbcs; Peto, Julian; Dos Santos Silva, Isabel; Couch, Fergus J; Olson, Janet E; Hillemans, Peter; Park-Simon, Tjoung-Won; Brauch, Hiltrud; Hamann, Ute; Burwinkel, Barbara; Marme, Frederik; Meindl, Alfons; Schmutzler, Rita K; Cox, Angela; Cross, Simon S; Sawyer, Elinor J; Tomlinson, Ian; Lambrechts, Diether; Moisse, Matthieu; Lindblom, Annika; Margolin, Sara; Hollestelle, Antoinette; Martens, John W M; Fasching, Peter A; Beckmann, Matthias W; Andrulis, Irene L; Knight, Julia A; Investigators, kConFab/Aocs; Anton-Culver, Hoda; Ziogas, Argyrios; Giles, Graham G; Milne, Roger L; Brenner, Hermann; Arndt, Volker; Mannermaa, Arto; Kosma, Veli-Matti; Chang-Claude, Jenny; Rudolph, Anja; Devilee, Peter; Seynaeve, Caroline; Hopper, John L; Southey, Melissa C; John, Esther M; Whittemore, Alice S; Bolla, Manjeet K; Wang, Qin; Michailidou, Kyriaki; Dennis, Joe; Easton, Douglas F; Schmidt, Marjanka K; Nevanlinna, Heli

2017-05-01

CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). Using genotype data from 39,139 (624 1100delC carriers) BC patients and 40,063 (224) healthy controls from 32 BCAC studies, we analyzed the combined risk effects of CHEK2*1100delC and 77 common variants in terms of a polygenic risk score (PRS) and pairwise interaction. The PRS conferred odds ratios (OR) of 1.59 (95% CI: 1.21-2.09) per standard deviation for BC for CHEK2*1100delC carriers and 1.58 (1.55-1.62) for noncarriers. No evidence of deviation from the multiplicative model was found. The OR for the highest quintile of the PRS was 2.03 (0.86-4.78) for CHEK2*1100delC carriers, placing them in the high risk category according to UK NICE guidelines. The OR for the lowest quintile was 0.52 (0.16-1.74), indicating a lifetime risk close to the population average. Our results confirm the multiplicative nature of risk effects conferred by CHEK2*1100delC and the common susceptibility variants. Furthermore, the PRS could identify carriers at a high lifetime risk for clinical actions.Genet Med advance online publication 06 October 2016.

Seasonal variation in chaetognath and parasite species assemblages along the northeastern coast of the Yucatan Peninsula.

PubMed

Lozano-Cobo, Horacio; Prado-Rosas, María Del Carmen Gómez Del; Sánchez-Velasco, Laura; Gómez-Gutiérrez, Jaime

2017-03-30

Chaetognaths are abundant carnivores with broad distributions that are intermediate hosts of trophically transmitted parasites. Monthly variations in chaetognath and parasite species distributions, abundance, prevalence, and intensity related to seasonal environmental changes were recorded in 2004 and 2005 in Laguna Nichupté, a coral reef, and the adjoining continental shelf of Quintana Roo, Mexico. Of 12 chaetognath species plus Sagitta spp., only 5 (Ferosagitta hispida, Flaccisagitta enflata, Sagitta spp., Serratosagitta serratodentata, and Pterosagitta draco) were parasitized. These species were parasitized with 33 types of flatworms and unidentified cysts (likely protozoan ciliates), having an overall mean prevalence of 6%. Digenean metacercaria larvae numerically dominated the parasite assemblages. Cluster analysis defined 2 chaetognath species assemblages. One included 7 species inside Laguna Nichupté, where F. hispida was numerically dominant (98.9%); the other contained 13 chaetognath species in the continental shelf-coral reef region, where F. enflata was abundant (53%). Canonical correspondence analysis showed that Laguna Nichupté had highly variable and hostile conditions (relatively low salinity and high temperature) for chaetognath species except for F. hispida. The higher density of F. hispida promoted greater parasite diversity (23 types), dominated by Brachyphallus sp. metacercariae. F. enflata prevailed in the continental shelf-coral reef area, which had stable high salinity and relatively low temperature. Monilicaecum and unidentified digenean 'type g' infected 5 chaetognath species on the continental shelf. Distinct primary hosts (mollusks and copepods) and contrasting environmental conditions (salinity, dissolved oxygen concentration, and temperature) between Laguna Nichupté and the continental shelf promoted distinct chaetognath species assemblages, resulting in distinct parasite diversity and prevalence patterns.

The Cuernos del Paine mountains in Torres del Paine National Park, Chile, during NASA's AirSAR 2004 campaign

NASA Image and Video Library

2004-03-11

The Cuernos del Paine mountains in Torres del Paine National Park, Chile, during NASA's AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition in Central and South America by an international team of scientists that is using an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), located onboard NASA's DC-8 airborne laboratory. Scientists from many parts of the world are combining ground research with NASA's AirSAR technology to improve and expand on the quality of research they are able to conduct. Founded in 1959, Torres del Paine National Park encompasses 450,000 acres in the Patagonia region of Chile. This region is being studied by NASA using a DC-8 equipped with an Airborne Synthetic Aperture Radar (AirSAR) developed by scientists from NASA’s Jet Propulsion Laboratory. This is a very sensitive region that is important to scientists because the temperature has been consistently rising causing a subsequent melting of the region’s glaciers. AirSAR will provide a baseline model and unprecedented mapping of the region. This data will make it possible to determine whether the warming trend is slowing, continuing or accelerating. AirSAR will also provide reliable information on ice shelf thickness to measure the contribution of the glaciers to sea level.

Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

NASA Astrophysics Data System (ADS)

Cirigliano, D.; Vial, J. C.; Rovira, M.

A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

Uso Del Condón en Adolescentes Nahuas, un Modelo Explicativo.

PubMed

Tirado, María de Los Ángeles Meneses; Benavides-Torres, Raquel A; Navarro, Sergio Meneses; de la Colina, Juan Antonio Doncel; Rodríguez, Dora Julia Onofre; Hernández, Francisco Javier Baéz

2018-03-01

En México, la población indígena supera los siete millones de habitantes, en Puebla el grupo más representativo es el Náhuatl. Sin embargo, las condiciones de vida, salud, educación y transporte son precarias para esta población. En los adolescentes, las responsabilidades como el matrimonio, la familia y los compromisos ante la comunidad, favorecen conductas de riesgo sexual que dificultan su desarrollo económico, social y reproductivo. El objetivo fue proponer un modelo explicativo del uso del condón en adolescentes nahuas. Método. Bajo el marco de la teoría social cognitiva, el concepto de valores culturales de Leininger y el proceso de la sustracción teórica, se desarrolló este artículo. Se muestran las relaciones del modelo con las proposiciones y los factores que influyen en el uso del condón para este grupo específico. Finalmente, el modelo explica las variables de interés, los niveles de abstracción y las relaciones entre sí en el contexto náhuatl. El siguiente paso será implementar los indicadores empíricos para conocer el grado de influencia de los factores personales y ambientales hacia el uso del condón en adolescentes nahuas. Resultados que aportarán información para el desarrollo del conocimiento en enfermería y la reducción de riesgo sexual de esta población.

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.

PubMed

Muranen, Taru A; Greco, Dario; Fagerholm, Rainer; Kilpivaara, Outi; Kämpjärvi, Kati; Aittomäki, Kristiina; Blomqvist, Carl; Heikkilä, Päivi; Borg, Ake; Nevanlinna, Heli

2011-09-20

Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels.Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions, we identified

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications

PubMed Central

2011-01-01

Introduction Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. Methods In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. Results We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels. Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. Conclusions We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation

Max Brödel: his art, legacy, and contributions to neurosurgery through medical illustration.

PubMed

Patel, Smruti K; Couldwell, William T; Liu, James K

2011-07-01

Max Brödel is considered the father of modern medical illustration. This report reviews his contributions to neurosurgery as a medical illustrator. Max Brödel, a young artist from Leipzig, Germany, was hired at Johns Hopkins Hospital in 1894, where he illustrated an operative textbook of gynecology for Howard A. Kelly. Although Brödel did not have any formal medical training, he quickly acquired knowledge of anatomy, pathology, physiology, and surgery. Brödel's extraordinary illustrations were characterized by an aerial perspective that conveyed the surgeon's operative viewpoint and precise surgical anatomy. He masterfully incorporated tissue realism with cross-sectional anatomy to accentuate concepts while maintaining topographical accuracy. Brödel's reputation spread quickly and resulted in collaborations with prominent surgeons, such as Cushing, Halsted, and Dandy. Cushing, who also possessed artistic talent, became a pupil of Brödel and remained a very close friend. In 1911, Brödel was appointed the director of the Department of Art as Applied to Medicine at Johns Hopkins, the first academic department of its kind in the world. For the next several decades, he trained generations of renowned medical illustrators. Just as Osler, Halsted, and Cushing passed their skills and knowledge to future leaders of medicine and surgery, Brödel did the same for the field of medical illustration. The advancement of neurosurgical education has been greatly facilitated by Max Brödel's artistic contributions. His unique ability to synthesize art and medicine resulted in timeless illustrations that remain indispensable to surgeons. The art produced by his legacy of illustrators continues to flourish in neurosurgical literature today.

Genetic modifiers of CHEK2*1100delC associated breast cancer risk

PubMed Central

Muranen, Taru A.; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno; Pharoah, Paul D.P.; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Bojesen, Stig E.; Nordestgaard, Børge G.; Schoemaker, Minouk; Swerdlow, Anthony; García-Closas, Montserrat; Figueroa, Jonine; Dörk, Thilo; Bogdanova, Natalia V.; Hall, Per; Li, Jingmei; Khusnutdinova, Elza; Bermisheva, Marina; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Peto, Julian; dos Santos Silva, Isabel; Couch, Fergus J.; Olson, Janet E.; Hillemans, Peter; Park-Simon, Tjoung-Won; Brauch, Hiltrud; Hamann, Ute; Burwinkel, Barbara; Marme, Frederik; Meindl, Alfons; Schmutzler, Rita K.; Cox, Angela; Cross, Simon S.; Sawyer, Elinor J.; Tomlinson, Ian; Lambrechts, Diether; Moisse, Matthieu; Lindblom, Annika; Margolin, Sara; Hollestelle, Antoinette; Martens, John W.M.; Fasching, Peter A.; Beckmann, Matthias W.; Andrulis, Irene L.; Knight, Julia A.; Anton-Culver, Hoda; Ziogas, Argyrios; Giles, Graham G.; Milne, Roger L.; Brenner, Hermann; Arndt, Volker; Mannermaa, Arto; Kosma, Veli-Matti; Chang-Claude, Jenny; Rudolph, Anja; Devilee, Peter; Seynaeve, Caroline; Hopper, John L.; Southey, Melissa C.; John, Esther M.; Whittemore, Alice S.; Bolla, Manjeet K.; Wang, Qin; Michailidou, Kyriaki; Dennis, Joe; Easton, Douglas F.; Schmidt, Marjanka K.; Nevanlinna, Heli

2016-01-01

Purpose CHEK2*1100delC is a founder variant in European populations conferring a 2–3 fold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have investigated this empirically using data from the Breast Cancer Association Consortium (BCAC). Methods With genotype data of 39,139 (624 1100delC carriers) BC patients and 40,063 (224) healthy controls from 32 BCAC studies, we analyzed the combined risk effects of CHEK2*1100delC and 77 common variants in terms of a polygenic risk score (PRS) and pairwise interaction. Results The PRS conferred an odds ratio (OR) of 1.59 [95% CI 1.21–2.09] per standard deviation for BC for CHEK2*1100delC carriers and 1.58 [1.55–1.62] for non-carriers. No evidence for deviation from the multiplicative model was found. The OR for the highest quintile of the PRS was 2.03 [0.86–4.78] for CHEK2*1100delC carriers placing them to the high risk category according to UK NICE guidelines. OR for the lowest quintile was 0.52 [0.16–1.74], indicating life-time risk close to population average. Conclusion Our results confirm the multiplicative nature of risk effects conferred by CHEK2*1100delC and the common susceptibility variants. Furthermore, the PRS could identify the carriers at a high life-time risk for clinical actions. PMID:27711073

Gödel metrics with chronology protection in Horndeski gravities

NASA Astrophysics Data System (ADS)

Geng, Wei-Jian; Li, Shou-Long; Lü, H.; Wei, Hao

2018-05-01

Gödel universe, one of the most interesting exact solutions predicted by General Relativity, describes a homogeneous rotating universe containing naked closed time-like curves (CTCs). It was shown that such CTCs are the consequence of the null energy condition in General Relativity. In this paper, we show that the Gödel-type metrics with chronology protection can emerge in Einstein-Horndeski gravity. We construct such exact solutions also in Einstein-Horndeski-Maxwell and Einstein-Horndeski-Proca theories.

Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos

PubMed Central

Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

2014-01-01

Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

Determinacion de Caracteristicas Opticas del Telescopio OAN150

NASA Astrophysics Data System (ADS)

Galan, M. J.; Cobos, F. J.

1987-05-01

En el Observatorio de Calar Alto, en Almería, España, está ubicado un telescopio de 15O-cms de diámetro -construído por REOSC- perteneciente al Observatorio Astronómico Nacional, con sede en Madrid, España. La infraestructura técnica del OAN ha sido tradicionalmente débil y actualmente se está haciendo un esfuerzo por fortalecerla. Existe una información muy limitada del telescopio en general; de su óptica en particular se conocían los valores de los parámetros principales pero sin saber si éstos corresponden a valores teóricos ó de construcción. Por ello se consideró necesario iniciar una investigación para conocer en detalle los valores reales de las componentes ópticas del telescopio, obteniéndose algunos resultados de interés. El primario del telescopio OANl5O es aproximadamente F/3 y el siste ma en su conjunto es F/8.2, con su sistema corrector de campo. En términos generales, la imagen es satisfactoria en todo el campo y, sin sistema corrector, la imagen axial también es buena. En un futuro muy cercano se piensa diseñar instrumentación adicional para este telescopio. Conocer con mayor precisión sus características puede ser de gran utilidad para tal fin, pues se efectúan los cálculos considerando conjuntamente al telescopio y al instrumento.

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells

PubMed Central

Stanton, Bruce A.; Coutermarsh, Bonita; Barnaby, Roxanna; Hogan, Deborah

2015-01-01

Background P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in combination with VX-770, to increase FEV1 (forced expiratory volume in 1 second) by an average of 3-5% in CF patients homozygous for the F508del-CFTR mutation. We propose that P. aeruginosa infection of CF lungs reduces VX-809 + VX-770- stimulated F508del-CFTR Cl secretion, and thereby reduces the clinical efficacy of VX-809 + VX-770. Methods and Results F508del-CFBE cells and primary cultures of CF-HBE cells (F508del/F508del) were exposed to VX-809 alone or a combination of VX-809 + VX-770 for 48 hours and the effect of P. aeruginosa on F508del-CFTR Cl secretion was measured in Ussing chambers. The effect of VX-809 on F508del-CFTR abundance was measured by cell surface biotinylation and western blot analysis. PAO1, PA14, PAK and 6 clinical isolates of P. aeruginosa (3 mucoid and 3 non-mucoid) significantly reduced drug stimulated F508del-CFTR Cl secretion, and plasma membrane F508del-CFTR. Conclusion The observation that P. aeruginosa reduces VX-809 and VX-809 + VX-770 stimulated F508del CFTR Cl secretion may explain, in part, why VX-809 + VX-770 has modest efficacy in clinical trials. PMID:26018799

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.

PubMed

Stanton, Bruce A; Coutermarsh, Bonita; Barnaby, Roxanna; Hogan, Deborah

2015-01-01

P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in combination with VX-770, to increase FEV1 (forced expiratory volume in 1 second) by an average of 3-5% in CF patients homozygous for the F508del-CFTR mutation. We propose that P. aeruginosa infection of CF lungs reduces VX-809 + VX-770- stimulated F508del-CFTR Cl secretion, and thereby reduces the clinical efficacy of VX-809 + VX-770. F508del-CFBE cells and primary cultures of CF-HBE cells (F508del/F508del) were exposed to VX-809 alone or a combination of VX-809 + VX-770 for 48 hours and the effect of P. aeruginosa on F508del-CFTR Cl secretion was measured in Ussing chambers. The effect of VX-809 on F508del-CFTR abundance was measured by cell surface biotinylation and western blot analysis. PAO1, PA14, PAK and 6 clinical isolates of P. aeruginosa (3 mucoid and 3 non-mucoid) significantly reduced drug stimulated F508del-CFTR Cl secretion, and plasma membrane F508del-CFTR. The observation that P. aeruginosa reduces VX-809 and VX-809 + VX-770 stimulated F508del CFTR Cl secretion may explain, in part, why VX-809 + VX-770 has modest efficacy in clinical trials.

Genomic profiling of CHEK2*1100delC-mutated breast carcinomas.

PubMed

Massink, Maarten P G; Kooi, Irsan E; Martens, John W M; Waisfisz, Quinten; Meijers-Heijboer, Hanne

2015-11-09

CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high prevalence in the Netherlands. We performed copy number and gene expression profiling to investigate whether CHEK2*1100delC breast cancers harbor characteristic genomic aberrations, as seen for BRCA1 mutated breast cancers. We performed high-resolution SNP array and gene expression profiling of 120 familial breast carcinomas selected from a larger cohort of 155 familial breast tumors, including BRCA1, BRCA2, and CHEK2 mutant tumors. Gene expression analyses based on a mRNA immune signature was used to identify samples with relative low amounts of tumor infiltrating lymphocytes (TILs), which were previously found to disturb tumor copy number and LOH (loss of heterozygosity) profiling. We specifically compared the genomic and gene expression profiles of CHEK2*1100delC breast cancers (n = 14) with BRCAX (familial non-BRCA1/BRCA2/CHEK2*1100delC mutated) breast cancers (n = 34) of the luminal intrinsic subtypes for which both SNP-array and gene expression data is available. High amounts of TILs were found in a relatively small number of luminal breast cancers as compared to breast cancers of the basal-like subtype. As expected, these samples mostly have very few copy number aberrations and no detectable regions of LOH. By unsupervised hierarchical clustering of copy number data we observed a great degree of heterogeneity amongst the CHEK2*1100delC breast cancers, comparable to the BRCAX breast cancers. Furthermore, copy number aberrations were mostly seen at low frequencies in both the CHEK2*1100delC and BRCAX group of breast cancers. However, supervised class comparison identified copy number loss of chromosomal arm 1p to be associated with CHEK2*1100delC status. In conclusion, in contrast to basal-like BRCA1 mutated breast cancers, no apparent specific somatic copy number aberration (CNA) profile for CHEK2*1100delC breast cancers was found. With the possible exception of copy

Summary of a Gas Transport Tracer Test in the Deep Cerros Del Rio Basalts, Mesita del Buey, Los Alamos NM.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stauffer, Philip H.; Rahn, Thomas A.; Ortiz, John Philip

Here we describe results from a tracer test in the Cerros del Rio basalt beneath Mesita del Buey, Technical Area 54 (TA-54) at Los Alamos National Laboratory (LANL or the Laboratory). This report follows from plans outlined in our previous Tracer Test Work Plan (LANL 2016). These activities were conducted by LANL to further characterize subsurface properties of the Cerros del Rio basalts at Material Disposal Area (MDA) L (Figure 1.1-1). The work presented follows from the “Interim Measures Work Plan for Soil-Vapor Extraction of Volatile Organic Compounds from Material Disposal Area L, Technical Area 54, Revision 1,” submitted tomore » the New Mexico Environment Department (NMED) in September 2014 (LANL 2014). Remediation of the MDA L vapor plume by soil-vapor extraction (SVE) is recommended as part of the final remedy in the “Corrective Measures Evaluation Report for Material Disposal Area L, Solid Waste Management Unit 54-006, at Technical Area 54, Revision 2” to meet a remedial action objective of preventing groundwater from being impacted above a regulatory standard by the transport of volatile organic compounds (VOCs) to groundwater through soil vapor (LANL 2011).« less

Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis.

PubMed

Esposito, Speranza; Tosco, Antonella; Villella, Valeria R; Raia, Valeria; Kroemer, Guido; Maiuri, Luigi

2016-12-01

Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disease with chronic inflammation and recurrent bacterial infections, pancreatic insufficiency, and male infertility. Therapies aimed at restoring the CFTR defect have emerged. Thus, a small molecule which facilitates chloride channel opening, the potentiator Ivacaftor, has been approved for the treatment of CF patients bearing a particular class of rare CFTR mutations. However, small molecules that directly target the most common misfolded CFTR mutant, F508del, and improve its intracellular trafficking in vitro, have been less effective than expected when tested in CF patients, even in combination with Ivacaftor. Thus, new strategies are required to circumvent the F508del-CFTR defect. Airway and intestinal epithelial cells from CF patients bearing the F508del-CFTR mutation exhibit an impressive derangement of cellular proteostasis, with oxidative stress, overactivation of the tissue transglutaminase (TG2), and disabled autophagy. Proteostasis regulators such as cysteamine can rescue and stabilize a functional F508del-CFTR protein through suppressing TG2 activation and restoring autophagy in vivo in F508del-CFTR homozygous mice, in vitro in CF patient-derived cell lines, ex vivo in freshly collected primary patient's nasal cells, as well as in a pilot clinical trial involving homozygous F508del-CFTR patients. Here, we discuss how the therapeutic normalization of defective proteostasis can be harnessed for the treatment of CF patients with the F508del-CFTR mutation.

Estudio multifrecuencia del medio interestelar cercano a HD 192281

NASA Astrophysics Data System (ADS)

Arnal, E. M.; Cappa, C.; Cichowolski, S.; Pineault, S.; St-Louis, N.

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de 21-cm del Hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100 micrones, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5 Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

Estudio multifrecuencia del medio interestelar cercano a HD 192281

NASA Astrophysics Data System (ADS)

Arnal, E. M.; Cappa, C. E.; Cichowolski, S.; Pineault, S.; St-Louis, N.

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de λ˜21-cm del hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100μm, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5,Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

[La diagnosi del disturbo da uso di alcol dal punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; Porrari, Raffaella; Battagliese, Gemma; Capriglione, Ida; Cereatti, Federica; Iannuzzi, Silvia; Mauri, Benilde; Galli, Domenica; Fiore, Marco; Attilia, Maria Luisa; Ceccanti, Mauro

2018-01-01

RIASSUNTO. Il disturbo da uso di alcol (DUA) è uno dei disturbi psichiatrici più comuni nella popolazione generale. Il DUA è caratterizzato da un pattern di bere eccessivo, che si mantiene nonostante gli effetti negativi che l'alcol ha sul funzionamento lavorativo, sulla salute, sulle problematiche legali, sull'educazione e sulla vita sociale. Attualmente, il modello bio-psico-sociale è quello che spiega meglio il DUA. Infatti, molte ricerche hanno fornito evidenze su come il DUA sia una patologia multidimensionale. Variabili biologiche, psicologiche e socio-culturali entrano in gioco nell'eziologia, nella natura, nel mantenimento e nel cambiamento nel tempo del disturbo. La fase diagnostica è un momento importante del processo di cura, perché il successo del trattamento dipende in larga misura dall'esattezza e dall'adeguatezza della diagnosi. La diagnosi clinica si basa su una valutazione globale del funzionamento del paziente e utilizza il colloquio e gli strumenti psicometrici come mezzo di raccolta di informazioni. Questo articolo fornirà una panoramica delle dimensioni psicologiche più importanti da valutare e sui migliori strumenti psicometrici da usare per una diagnosi adeguata.

Historical bac-barrier shoreline changes, Padre Island National Seashore, Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prouty, J.S.

1989-09-01

Historical progradation rates of the Laguna Madre shoreline at Padre Island National Seashore have varied considerably, largely in response to rainfall fluctuations and perhaps grazing pressure. Analysis of aerial photographs indicates that near the northern margin of the National Seashore the shoreline prograded at an average rate of 26 ft/year between 1941 and 1950. The average rate of progradation increased to 42 ft/year between 1950 and 1964. Average rates then slowed in the late 1960s, and since 1969 the shoreline has prograded at an average rate of only 1 ft/year. Some areas of the shoreline are presently eroding. Early mapsmore » and accounts suggest that a century ago North Padre Island was largely vegetated. Overgrazing and a series of droughts in the late 19th and early 20th centuries denuded the island, and prevailing winds blew sand westward across the island into Laguna Madre. With higher than average rainfall in the past 2 decades and less grazing, the island has significantly revegetated. Winds now carry less sand to Laguna Madre; reduced sand supply is a major cause of present-day shoreline retreat.« less

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility*

PubMed Central

Mitzelfelt, Katie A.; Limphong, Pattraranee; Choi, Melinda J.; Kondrat, Frances D. L.; Lai, Shuping; Kolander, Kurt D.; Kwok, Wai-Meng; Dai, Qiang; Grzybowski, Michael N.; Zhang, Huali; Taylor, Graydon M.; Lui, Qiang; Thao, Mai T.; Hudson, Judith A.; Barresi, Rita; Bushby, Kate; Jungbluth, Heinz; Wraige, Elizabeth; Geurts, Aron M.; Benesch, Justin L. P.; Riedel, Michael; Christians, Elisabeth S.; Minella, Alex C.; Benjamin, Ivor J.

2016-01-01

Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to multisystem disorders featuring variable combinations of cataracts, cardiomyopathy, and skeletal myopathy. This study aimed to investigate the pathological mechanisms involved in an early-onset myofibrillar myopathy manifesting in a child harboring a homozygous recessive mutation in HSPB5, 343delT. To study HSPB5 343delT protein dynamics, we utilize model cell culture systems including induced pluripotent stem cells derived from the 343delT patient (343delT/343delT) along with isogenic, heterozygous, gene-corrected control cells (WT KI/343delT) and BHK21 cells, a cell line lacking endogenous HSPB5 expression. 343delT/343delT and WT KI/343delT-induced pluripotent stem cell-derived skeletal myotubes and cardiomyocytes did not express detectable levels of 343delT protein, contributable to the extreme insolubility of the mutant protein. Overexpression of HSPB5 343delT resulted in insoluble mutant protein aggregates and induction of a cellular stress response. Co-expression of 343delT with WT prevented visible aggregation of 343delT and improved its solubility. Additionally, in vitro refolding of 343delT in the presence of WT rescued its solubility. We demonstrate an interaction between WT and 343delT both in vitro and within cells. These data support a loss-of-function model for the myopathy observed in the patient because the insoluble mutant would be unavailable to perform normal functions of HSPB5, although additional gain-of-function effects of the mutant protein cannot be excluded. Additionally, our data highlight the solubilization of 343delT by WT, concordant with the recessive inheritance of the disease and absence of symptoms in carrier individuals. PMID:27226619

63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Del(20q) in patients with chronic lymphocytic leukemia: A therapy-related abnormality involving lymphoid or myeloid cells

PubMed Central

Yin, C. Cameron; Tang, Guilin; Lu, Gary; Feng, Xiaoli; Keating, Michael J.; Medeiros, L. Jeffrey; Abruzzo, Lynne V.

2015-01-01

Del(20q), a common cytogenetic abnormality in myeloid neoplasms, is rare in chronic lymphocytic leukemia. We report 64 patients with chronic lymphocytic leukemia and del(20q), as the sole abnormality in 40, a stemline abnormality in 21, and a secondary abnormality in 3 cases. FISH analysis revealed an additional high-risk abnormality, del(11q) or del(17p), in 27/64 (42%) cases. In most cases, the leukemic cells showed atypical cytologic features, unmutated IGHV genes and ZAP70 positivity. The del(20q) was detected only after chemotherapy in all 27 cases with initial karyotypes available. With a median follow-up of 90 months, 30 patients (47%) died, most as a direct consequence of chronic lymphocytic leukemia. Eight patients developed a therapy-related myeloid neoplasm, seven with a complex karyotype. Combined morphologic and FISH analysis for del(20q) performed in 12 cases without morphologic evidence of a myeloid neoplasm localized the del(20q) to the chronic lymphocytic leukemia cells in 5 (42%) cases, and to myeloid/erythroid cells in 7 (58)% cases. The del(20q) was detected in myeloid cells in all 4 cases of myelodysplastic syndrome. In aggregate, these data indicate that chronic lymphocytic leukemia with del(20q) acquired after therapy is heterogeneous. In cases with morphologic evidence of dysplasia, the del(20q) likely resides in the myeloid lineage. However, in cases without morphologic evidence of dysplasia, the del(20q) may represent clonal evolution and disease progression. Combining morphologic analysis with FISH for del(20q) or performing FISH on immunomagnetically-selected subpopulations to localize the cell population with this abnormality may help guide patient management. PMID:25953391

Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.

PubMed

Nagel, Jord H A; Peeters, Justine K; Smid, Marcel; Sieuwerts, Anieta M; Wasielewski, Marijke; de Weerd, Vanja; Trapman-Jansen, Anita M A C; van den Ouweland, Ans; Brüggenwirth, Hennie; van I Jcken, Wilfred F J; Klijn, Jan G M; van der Spek, Peter J; Foekens, John A; Martens, John W M; Schutte, Mieke; Meijers-Heijboer, Hanne

2012-04-01

CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with previous work, all CHEK2 1100delC mutant tumors clustered among the hormone receptor-positive breast cancers. In the hormone receptor-positive subset, a 40-gene CHEK2 signature was subsequently defined that significantly associated with CHEK2 1100delC breast cancers. The identification of a CHEK2 gene signature implies an unexpected biological homogeneity among the CHEK2 1100delC breast cancers. In addition, all 26 CHEK2 1100delC tumors classified as luminal intrinsic subtype breast cancers, with 8 luminal A and 18 luminal B tumors. This biological make-up of CHEK2 1100delC breast cancers suggests that a relatively limited number of additional susceptibility alleles are involved in the polygenic CHEK2 model. Identification of these as-yet-unknown susceptibility alleles should be aided by clues from the 40-gene CHEK2 signature.

Eruptive Massive Vector Particles of 5-Dimensional Kerr-Gödel Spacetime

NASA Astrophysics Data System (ADS)

Övgün, A.; Sakalli, I.

2018-02-01

In this paper, we investigate Hawking radiation of massive spin-1 particles from 5-dimensional Kerr-Gödel spacetime. By applying the WKB approximation and the Hamilton-Jacobi ansatz to the relativistic Proca equation, we obtain the quantum tunneling rate of the massive vector particles. Using the obtained tunneling rate, we show how one impeccably computes the Hawking temperature of the 5-dimensional Kerr-Gödel spacetime.

Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells.

PubMed

Yin, C Cameron; Tang, Guilin; Lu, Gary; Feng, Xiaoli; Keating, Michael J; Medeiros, L Jeffrey; Abruzzo, Lynne V

2015-08-01

Deletion 20q (Del(20q)), a common cytogenetic abnormality in myeloid neoplasms, is rare in chronic lymphocytic leukemia. We report 64 patients with chronic lymphocytic leukemia and del(20q), as the sole abnormality in 40, a stemline abnormality in 21, and a secondary abnormality in 3 cases. Fluorescence in situ hybridization (FISH) analysis revealed an additional high-risk abnormality, del(11q) or del(17p), in 25/64 (39%) cases. In most cases, the leukemic cells showed atypical cytologic features, unmutated IGHV (immunoglobulin heavy-chain variable region) genes, and ZAP70 positivity. The del(20q) was detected only after chemotherapy in all 27 cases with initial karyotypes available. With a median follow-up of 90 months, 30 patients (47%) died, most as a direct consequence of chronic lymphocytic leukemia. Eight patients developed a therapy-related myeloid neoplasm, seven with a complex karyotype. Combined morphologic and FISH analysis for del(20q) performed in 12 cases without morphologic evidence of a myeloid neoplasm localized the del(20q) to the chronic lymphocytic leukemia cells in 5 (42%) cases, and to myeloid/erythroid cells in 7 (58)% cases. The del(20q) was detected in myeloid cells in all 4 cases of myelodysplastic syndrome. In aggregate, these data indicate that chronic lymphocytic leukemia with del(20q) acquired after therapy is heterogeneous. In cases with morphologic evidence of dysplasia, the del(20q) likely resides in the myeloid lineage. However, in cases without morphologic evidence of dysplasia, the del(20q) may represent clonal evolution and disease progression. Combining morphologic analysis with FISH for del(20q) or performing FISH on immunomagnetically selected sub-populations to localize the cell population with this abnormality may help guide patient management.

62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION D, HIGHWAY 1. REDWOOD CLEARING ON EXISTING LINE, 1-DN-71-A #26, R.L.T. 11-1-34. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #538, KLAMATH RIVER BR. FROM SO. END, 12/23/55, C.J.T. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

Volcanic deformation in the Andes

NASA Astrophysics Data System (ADS)

Riddick, S.; Fournier, T.; Pritchard, M.

2009-05-01

We present the results from an InSAR survey of volcanic activity in South America. We use data from the Japanese Space Agency's ALOS L-band radar satellite from 2006-2009. The L-band instrument provides better coherence in densely vegetated regions, compared to the shorter wave length C-band data. The survey reveals volcano related deformation in regions, north, central and southern, of the Andes volcanic arc. Since observations are limited to the austral summer, comprehensive coverage of all volcanoes is not possible. Yet, our combined observations reveal volcanic/hydrothermal deformation at Lonquimay, Llaima, Laguna del Maule, and Chaitén volcanoes, extend deformation measurements at Copahue, and illustrate temporal complexity to the previously described deformation at Cerro Hudson and Cordón Caulle. No precursory deformation is apparent before the large Chaitén eruption (VEI_5) of 2 May 2008, (at least before 16 April) suggesting rapid magma movement from depth at this long dormant volcano. Subsidence at Ticsani Volcano occurred coincident with an earthquake swarm in the same region.

Digitalización de diapositivas del Sol en H α

NASA Astrophysics Data System (ADS)

Missio, H.; Montenegro, C.; Montenegro, R.

El objetivo de este trabajo ha sido el de obtener imágenes digitalizadas de las diapositivas tomadas del Sol en luz de hidrógeno de la línea correspondiente a Hα, y de esta manera llegar a convertir las mismas a un archivo digital para poder ser tratadas luego por computadora y poder contabilizar con exactitud, mediante un programa adecuado para tal fin, las zonas activas del Sol en la imagen digitalizada. En principio, para llegar a esto se pensó en la utilización de medios accesibles, y como detector se utilizó un fototransistor ubicado dentro de un soporte rectangular sobre dos ejes de desplazamiento X e Y. Se han obtenido con este procedimiento imágenes de buena calidad, construídas a partir de tres datos digitalizados en cada barrido que aportan la posición X e Y y la intensidad del pixel en ese punto indicada en 255 tonos de grises.

CHEK2 (∗) 1100delC Mutation and Risk of Prostate Cancer.

PubMed

Hale, Victoria; Weischer, Maren; Park, Jong Y

2014-01-01

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer. CHEK2 plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, of CHEK2 on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussed CHEK2 (∗)1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23-3.18) for unselected cases and 3.39 (1.78-6.47) for familial cases, indicating that CHEK2 (∗)1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2(∗)1100delC should be considered in men with a familial history of prostate cancer.

CHEK2 ∗1100delC Mutation and Risk of Prostate Cancer

PubMed Central

Park, Jong Y.

2014-01-01

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer. CHEK2 plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, of CHEK2 on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussed CHEK2 ∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating that CHEK2 ∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer. PMID:25431674

The Cuernos del Paine mountains in Torres del Paine National Park in Chile, photographed during NASA's AirSAR 2004 campaign

NASA Image and Video Library

2004-03-11

The Cuernos del Paine mountains in Torres del Paine National Park in Chile, photographed during NASA's AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition in Central and South America by an international team of scientists that is using an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), located onboard NASA's DC-8 airborne laboratory. Scientists from many parts of the world are combining ground research with NASA's AirSAR technology to improve and expand on the quality of research they are able to conduct. Founded in 1959, Torres del Paine National Park encompasses 450,000 acres in the Patagonia region of Chile. This region is being studied by NASA using a DC-8 equipped with an Airborne Synthetic Aperture Radar (AirSAR) developed by scientists from NASA’s Jet Propulsion Laboratory. This is a very sensitive region that is important to scientists because the temperature has been consistently rising causing a subsequent melting of the region’s glaciers. AirSAR will provide a baseline model and unprecedented mapping of the region. This data will make it possible to determine whether the warming trend is slowing, continuing or accelerating. AirSAR will also provide reliable information on ice shelf thickness to measure the contribution of the glaciers to sea level.

Surveillance for White-Nose Syndrome in the bat community at El Malpais National Monument, New Mexico, 2011

USGS Publications Warehouse

Valdez, Ernest W.

2012-01-01

From late winter to summer 2011, the U.S. Geological Survey Arid Lands Field Station conducted mist-netting efforts at El Malpais National Monument and on adjacent lands belonging to Bureau of Land Management and U.S. Forest Service to detect the occurrence of white-nose syndrome or causal fungal agent (Geomyces destructans). During this assessment, 421 bats belonging to 8 species were documented at El Malpais National Monument and adjacent lands. None of these captures showed evidence for the presence of white-nose syndrome or G. destructans, but it is possible that the subtle signs of some infections may not have been observed. Throughout the field efforts, Laguna de Juan Garcia was the only water source located on El Malpais National Monument and was netted on June 20 and 27, July 25, and August 2, 2011. During these dates, a total of 155 bats were captured, belonging to eight species including: Corynorhinus townsendii (Townsend's Big-Eared Bat), Eptesicus fuscus (Big Brown Bat), Lasionycterics noctivagans (Silver-Haired Bat), Myotis ciliolabrum (Small-Footed Myotis), M. evotis (Long-eared myotis), M. thysanodes (Fringed Myotis), M. volans (Long-Legged Myotis), and Tadarida brasiliensis (Brazilian Free-Tailed Bat). Overall, Laguna de Juan Garcia had the greatest number of captures (79 bats) during one night compared to the other sites netted on adjacent lands and had the greatest species diversity of 8 species netted, not including Euderma maculatum (Spotted Bat) that was detected by its audible calls as it flew overhead. Laguna de Juan Garcia is an important site to bats because of its accessibility by all known occurring species, including the less-maneuverable T. brasiliensis that is known to form large colonies in the park. Laguna de Juan Garcia is also important as a more permanent water source during drought conditions in the earlier part of the spring and summer, as observed in 2011.

Diurnal time-activity budgets of redheads (Aythya americana) wintering in seagrass beds and coastal ponds in Louisiana and Texas

USGS Publications Warehouse

Michot, T.C.; Woodin, M.C.; Adair, S.E.; Moser, E.B.

2006-01-01

Diurnal time-activity budgets were determined for wintering redheads (Aythya americana) from estuarine seagrass beds in Louisiana (Chandeleur Sound) and Texas (Laguna Madre) and from ponds adjacent to the Laguna Madre. Activities differed (p<0.0001) by location, month, and diurnal time period. Resting and feeding were the most frequent activities of redheads at the two estuarine sites, whereas drinking was almost nonexistent. Birds on ponds in Texas engaged most frequently in resting and drinking, but feeding was very infrequent. Redheads from the Louisiana estuarine site rested less than birds in Texas at either the Laguna Madre or freshwater ponds. Redheads in Louisiana fed more than birds in Texas; this was partially because of weather differences (colder temperatures in Louisiana), but the location effect was still significant even when we adjusted the model for weather effects. Redheads in Louisiana showed increased resting and decreased feeding as winter progressed, but redheads in Texas did not exhibit a seasonal pattern in either resting or feeding. In Louisiana, birds maintained a high level of feeding activity during the early morning throughout the winter, whereas afternoon feeding tapered off in mid- to late-winter. Texas birds showed a shift from morning feeding in early winter to afternoon feeding in late winter. Males and females at both Chandeleur Sound and Laguna Madre showed differences in their activities, but because the absolute difference seldom exceeded 2%, biological significance is questionable. Diurnal time-activity budgets of redheads on the wintering grounds are influenced by water salinities and the use of dietary fresh water, as well as by weather conditions, tides, and perhaps vegetation differences between sites. The opportunity to osmoregulate via dietary freshwater, vs. via nasal salt glands, may have a significant effect on behavioral allocations. ?? Springer 2006.

Herbivory on shoalgrass by wintering redheads in Texas

USGS Publications Warehouse

Mitchell, C.A.; Custer, T.W.; Zwank, P.J.

1994-01-01

An estimated 80% of redheads (Aythya americana) winter on the Laguna Madre of south Texas and Mexico and feed almost exclusively on shoalgrass (Halodule wrightii) rhizomes. Shoalgrass abundance has decreased by 60% over the past 30 years, and because the effects of shoalgrass loss on wintering redheads are unknown, we initiated a study to define habitat selection criteria and document the effect of wintering redheads on shoalgrass in the lower Laguna Madre, Texas. Redheads consumed an average of 75% of shoalgrass rhizome biomass at collection sites each winter. When rhizome biomass was grazed to a mean biomass of ltoreq 0.18 g dry mass/core (approximately 10 g dry mass/ml), shoalgrass did not recover to its previous level the following growing season. Thirty-three percent of the sites (10) were grazed below 0.18 g dry mass/core during both years of the study, while 64% (19) were grazed below 0.18 g during 1 or the other of the 2 winters. Ramet number was positively correlated (P lt 0.001, r-2 = 0.54) with rhizome biomass; however, this relationship was influenced by grazing intensity. Heavy grazing reduced the amount of rhizome attached to each ramet compared with ungrazed ramets. Grazing had no effect on root biomass (P = 0.388), rhizome moisture content (P = 0.553), or soil magnesium, phosphorous, and potassium (P = 0.102, 0.499, 0.162, respectively). Redhead presence increased (P = 0.042) soil nitrogen levels. Foraging areas selected by redheads within the lower Laguna Madre had lower (P = 0.026) salinities (24 ppt) than areas not selected (35 ppt). Redheads did not select foraging areas in relation to crude protein levels in rhizomes. Shoalgrass habitat in the Laguna Madre should be protected from further losses and enhanced where possible.

El ``Aula del Cel'': astronomy approaching high school

NASA Astrophysics Data System (ADS)

Ortiz-Gil, A.; Gómez Collado, M.; Gallego Calvente, A. T.

The “Aula del Cel” is a project carried out by the Astronomical Obsevatory of the University of Valencia, Spain. It offers high-school teachers a tool for teaching Astronomy to 10 to 17 year-old students. Different programs, experiments, and audiovisual presentations have been prepared by a team formed both by professional astronomers and teachers, and are offered in a format chosen to suit each particular age and curriculum group. Special sessions have been designed for students with special needs (for example blind or autistic children) in close contact with the pedagogical teams responsible for their education. Nearly three thousand students have already visited the “Aula del Cel” over the first six months that it has been offered to the school community.

CHEK2*1100delC homozygosity in the Netherlands—prevalence and risk of breast and lung cancer

PubMed Central

Huijts, Petra EA; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly MM; Wijnen, Juul; Berns, Els MJJ; Martens, John WM; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob AEM; Devilee, Peter; van Asperen, Christi J

2014-01-01

The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4–32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency. PMID:23652375

Primer registro para Peru del genero Nielsonia Young, 1977 (Hemiptera: Cicadellidae: Cicadellinae: Cicadellini)

USDA-ARS?s Scientific Manuscript database

En este articulo se reporta por primera vez para el Peru una especies del genero Nielsonia Young, 1977, de material procedente del Departamento de Tumbes. El genero ha sido reportada anteriormente de Ecuador, como unico registro para Sudamerica, y America Central. El unico especimen hembra encontra...

Ectopsocidae (Psocodea: 'Psocoptera') from Valle del Cauca and NNP Gorgona, Colombia.

PubMed

Manchola, Oscar Fernando Saenz; Obando, Ranulfo González; Aldrete, Alfonso N García

2014-04-14

The results of a survey of the psocid family Ectopsocidae in Valle del Cauca and NNP Gorgona, are here presented. Fifteen species were identified, in the genera Ectopsocus (14 species), and Ectopsocopsis (one species); four of the Ectopsocus species are new to science and are here described and illustrated. The male of E. thorntoni García Aldrete is here described. Records of Ectopsocopsis cryptomeriae (Enderlein), Ectopsocus briggsi McLachlan, E. californicus Banks, E. columbianus Badonnel, E. maindroni Badonnel, E. meridionalis Ribaga, E. pilosus Badonnel, E. richardsi Pearman, E. titschacki Jentsch, and E. vilhenai Badonnel, are provided. Ten species were found only in Valle del Cauca, two species were found only in the NNP Gorgona, and three species were found at both sites. The specimens studied are deposited in the Entomological Museum, Universidad del Valle, Santiago de Cali, Colombia (MUSENUV).

Desgarros del epitelio pigmentario de la retina: factores de riesgo, mecanismo y control terapéutico.

PubMed

Clemens, Christoph R; Eter, Nicole

2017-07-11

Los desgarros del epitelio pigmentario de la retina (EPR) se asocian en la mayoría de los casos con los desprendimientos vascularizados del EPR debido a una degeneración macular asociada a la edad (DMAE), y normalmente implican una pérdida adversa de la agudeza visual. Estudios recientes indican que ha habido un aumento en la incidencia de desgarros del EPR desde la introducción de fármacos anti-factor de crecimiento del endotelio vascular (anti-VEGF) así como una asociación temporal entre el desgarro y la inyección intravítrea. Dado que el número de pacientes con DMAE y el número de inyecciones anti-VEGF va en aumento, tanto la dificultad de prevenir desgarros del EPR como el tratamiento tras la formación de los desgarros han adquirido una mayor relevancia. De forma paralela, la evolución de la imagenología de la retina ha contribuido de manera significativa a comprender mejor el desarrollo de los desgarros del EPR en los últimos años. Esta revisión resume los conocimientos que se poseen actualmente sobre el desarrollo, los factores pronósticos y las estrategias terapéuticas de los desgarros del EPR antes y después de que estos se formen. © 2017 S. Karger AG, Basel.

Recent temperature trends in the South Central Andes reconstructed from sedimentary chrysophyte stomatocysts in Laguna Escondida (1742 m a.s.l., 38°28 S, Chile)

NASA Astrophysics Data System (ADS)

De Jong, R.; Schneider, T.; Hernández-Almeida, I.; Grosjean, M.

2016-02-01

In this study we present a quantitative, high resolution reconstruction of past austral winter length in the Chilean Andes at 38°S from AD 1920 to 2009. For Laguna Escondida, a nearly pristine lake situated on the flanks of the Andes at 1740 m above sea level, past variability in the duration of the winter season (Days T4 °C) was reconstructed. Because high elevation meteorological stations are absent in this region, the reconstruction provides novel insights into recent temperature trends in the central-southern Andes. As a cold-season temperature proxy, we used chrysophyte stomatocysts. This novel proxy for cold season temperature was so far applied successfully in the European Alps and Pyrenees but has not yet been tested in the Southern Hemisphere. The reconstruction in this study was based on a newly developed Transfer Function to estimate Days T4 °C (number of consecutive days with surface water temperatures at or below 4 °C) from sedimentary stomatocyst assemblages (R2boot = 0.8, RMSEPboot = 28.7 days (= half the standard deviation)). To develop a high quality TF model, sediment traps and thermistors were placed in thirty remote lakes along an altitude gradient (420-2040 m a.s.l.). Complete materials and data were collected in 24 lakes after one year. Detailed statistical analyses indicate that modern stomatocysts primarily respond to the length of the cold season. The TF model was then applied to the sedimentary stomatocysts from a 210Pb-dated short core of L. Escondida. Comparison to independent reanalysis data showed that reconstructed changes in Days T4°C provides detailed information on winter-spring temperature variability since AD 1920. The reconstruction shows that recent warming (onset in AD 1980) in the southern Chilean Andes was not exceptional in the context of the past century. This is in strong contrast to studies from the Northern Hemisphere. The finding is also in contrast to the cooling temperature trends which were detected using

33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Del.; naval restricted area. 334.110 Section 334.110 Navigation and Navigable Waters CORPS OF....110 Delaware Bay off Cape Henlopen, Del.; naval restricted area. (a) The area. Beginning at a point on... regulations in this section shall be enforced by the Commandant, Fourth Naval District, and such agencies as...

Modeling landscapes and past vegetation patterns of New Mexico's Rio Del Oso Valley

Treesearch

Richard D. Periman

2005-01-01

Humans have interacted with the landscape and ecosystem of New Mexico's Rio del Oso Valley for thousands of years. Throughout the Holocene, various cultures have dramatically affected and altered the Rio del Oso. An interdisciplinary research approach, incorporating geomorphology, paleobotany, archaeology, and history, provides a broad range of methodologies and...

El Alcalde José Carlos Aponte Dalmau del Municipio de Carolina es nombrado a formar parte del Comité Asesor de Gobiernos Locales de la EPA a nivel de todos los Estados Unidos

EPA Pesticide Factsheets

Comunicado de prensa de la EPA: El Alcalde José Carlos Aponte Dalmau del Municipio de Carolina es nombrado a formar parte del Comité Asesor de Gobiernos Locales de la EPA a nivel de todos los Estados Unidos

El bosque estatal del nuevo milenio antes y después del huracán Georges

Treesearch

A.E. Lugo; E. Román Nunci; M. Quinones; H. Marcano Vega; I. Vicéns

2005-01-01

We studied changes that occurred between 1997 and 2005 on a secondary wet subtropical urban forest in the University of Puerto Rico’s Botanical Garden (Bosque Estatal del Nuevo Milenio). Hurricane Georges passed south of the forest on November 21, 1998 with 127 km/h winds. The study consisted of identifying species in 40 plots of 254 m2 each, measuring the diameter at...

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.

PubMed

Maekawa, Tomoki; Hosur, Kavita; Abe, Toshiharu; Kantarci, Alpdogan; Ziogas, Athanasios; Wang, Baomei; Van Dyke, Thomas E; Chavakis, Triantafyllos; Hajishengallis, George

2015-09-16

Del-1 is an endothelial cell-secreted anti-inflammatory protein. In humans and mice, Del-1 expression is inversely related to that of IL-17, which inhibits Del-1 through hitherto unidentified mechanism(s). Here we show that IL-17 downregulates human endothelial cell expression of Del-1 by targeting a critical transcription factor, C/EBPβ. Specifically, IL-17 causes GSK-3β-dependent phosphorylation of C/EBPβ, which is associated with diminished C/EBPβ binding to the Del-1 promoter and suppressed Del-1 expression. This inhibitory action of IL-17 can be reversed at the GSK-3β level by PI3K/Akt signalling induced by D-resolvins. The biological relevance of this regulatory network is confirmed in a mouse model of inflammatory periodontitis. Intriguingly, resolvin-D1 (RvD1) confers protection against IL-17-driven periodontal bone loss in a Del-1-dependent manner, indicating an RvD1-Del-1 axis against IL-17-induced pathological inflammation. The dissection of signalling pathways regulating Del-1 expression provides potential targets to treat inflammatory diseases associated with diminished Del-1 expression, such as periodontitis and multiple sclerosis.

An unexpected effect of TNF-α on F508del-CFTR maturation and function

PubMed Central

Bitam, Sara; Urbach, Valérie; Sermet-Gaudelus, Isabelle; Hinzpeter, Alexandre; Edelman, Aleksander

2015-01-01

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a cAMP-dependent Cl - channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially functional protein. CFTR is expressed in many epithelia, with major consequences in the airways of patients with CF, characterized by both fluid transport abnormalities and persistent inflammatory responses. The relationship between the acute phase of inflammation and the expression of wild type (WT) CFTR or F508del-CFTR is poorly understood. The aim of the present study was to investigate this effect. The results show that 10 min exposure to TNF-alpha (0.5-50ng/ml) of F508del-CFTR-transfected HeLa cells and human bronchial cells expressing F508del-CFTR in primary culture (HBE) leads to the maturation of F508del-CFTR and induces CFTR chloride currents. The enhanced CFTR expression and function upon TNFα is sustained, in HBE cells, for at least 24 h. The underlying mechanism of action involves a protein kinase C (PKC) signaling pathway, and occurs through insertion of vesicles containing F508del-CFTR to the plasma membrane, with TNFα behaving as a corrector molecule. In conclusion, a novel and unexpected action of TNFα has been discovered and points to the importance of systematic studies on the roles of inflammatory mediators in the maturation of abnormally folded proteins in general and in the context of CF in particular. PMID:26594334

Weyl fermions in a family of Gödel-type geometries with a topological defect

NASA Astrophysics Data System (ADS)

Garcia, G. Q.; Oliveira, J. R. De S.; Furtado, C.

In this paper, we study Weyl fermions in a family of Gödel-type geometries in Einstein general relativity. We also consider that these solutions are embedded in a topological defect background. We solve the Weyl equation and find the energy eigenvalues and eigenspinors for all three cases of Gödel-type geometries where a topological defect is passing through them. We show that the presence of a topological defect in these geometries contributes to the modification of the spectrum of energy. The energy zero modes for all three cases of the Gödel geometries are discussed.

General nonextremal rotating charged Gödel black holes in minimal five-dimensional gauged supergravity.

PubMed

Wu, Shuang-Qing

2008-03-28

I present the general exact solutions for nonextremal rotating charged black holes in the Gödel universe of five-dimensional minimal supergravity theory. They are uniquely characterized by four nontrivial parameters: namely, the mass m, the charge q, the Kerr equal rotation parameter a, and the Gödel parameter j. I calculate the conserved energy, angular momenta, and charge for the solutions and show that they completely satisfy the first law of black hole thermodynamics. I also study the symmetry and separability of the Hamilton-Jacobi and the massive Klein-Gordon equations in these Einstein-Maxwell-Chern-Simons-Gödel black hole backgrounds.

La implantacion del enfoque constructivista en el aula de ciencia: Estudio de caso multiple

NASA Astrophysics Data System (ADS)

Arroyo Betancourt, Luz I.

Esta investigacion estudia la implantacion del enfoque constructivista en tres aulas de ciencia del contexto puertorriqueno. Se auscultaron las practicas educativas que utilizan maestras consideradas constructivistas y la correspondencia de sus practicas educativas con los elementos esenciales de la didactica que proponen los teoricos de los planteamientos constructivistas. Se ausculto, ademas, a que vision del enfoque constructivista responden las expresiones de las maestras acerca de su practica educativa y como compara con su quehacer, a la luz de los elementos esenciales de las visiones constructivistas piagetiana, social y radical. Se utilizo el diseno de estudio descriptivo de caso multiple. El estudio se baso en entrevistas a profundidad, revision de documentos y observacion no participativa a la sala de clases. El contexto fueron tres escuelas publicas de la Region Educativa de San Juan, una elemental, una intermedia y una superior. Los resultados confirmaron que la transicion hacia el enfoque constructivista es un proceso que toma tiempo, dedicacion y la participacion en adiestramientos y readiestramientos acerca del nuevo enfoque. Las maestras coinciden en la mayoria de las practicas educativas que utilizan para implantar el enfoque constructivista de ensenanza y difieren en algunas debido, probablemente, a que han tenido que adaptarlas a los correspondientes niveles de ensenanza: elemental, intermedio y superior. Dos de las maestras planifican por conceptos generadores, mientras que una de ellas planifica siguiendo la guia que recibe del Departamento de Educacion. Difieren ademas, en el enfasis que confieren al inquirir cientifico. Con relacion a la correspondencia entre la vision manifestada por las maestras a la luz de las visiones piagetiana, social y radical, aparentemente, las preguntas del protocolo de entrevistas no lograron evocar la informacion con suficiente profundidad, por lo que la investigadora tuvo que inferir las visiones de las

Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

PubMed Central

Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

2010-01-01

OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

An evening at "La Clinica del Pueblo".

PubMed

Shefsky, M L

1986-01-01

This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program.

The novel complex allele [A238V;F508del] of the CFTR gene: clinical phenotype and possible implications for cystic fibrosis etiological therapies.

PubMed

Diana, Anna; Polizzi, Angela Maria; Santostasi, Teresa; Ratclif, Luigi; Pantaleo, Maria Giuseppina; Leonetti, Giuseppina; Iusco, Danila Rosa; Gallo, Crescenzio; Conese, Massimo; Manca, Antonio

2016-06-01

Few mutations in cis have been annotated for F508del homozygous patients. Southern Italy patients who at a first analysis appeared homozygous for the F508del mutation (n=63) or compound heterozygous for the F508del and another mutation in the cystic fibrosis transmembrane conductance regulator gene (n=155) were searched for the A238V mutation in exon 6. The allelic frequency of the complex allele [A238V;F508del] was 0.04. When the whole data set was used (comprised also of 56 F508del/F508del and 34 F508del/other mutation controls), no differences reached the statistical significance in the clinical parameters, except chloride concentrations which were lower in [A238V;F508del]/other mutation compared with F508del/other mutation (P=0.03). The two study groups presented less complications than the control groups. Within the minimal data set (34 F508del/F508del, 27 F508del/other mutation, 4 [A238V;F508del]/F508del cases and 5 [A238V;F508del]/other mutation cases); that is, presenting all the variables in each patient, forced expiratory volume in 1 s and forced vital capacity presented a trend to lower levels in the study groups in comparison with the F508del/F508del group, and C-reactive protein approximated statistically significant higher levels in the [A238V;F508del]/other mutation as compared with F508del/F508del patients (P=0.09). The analysis of statistical dependence among the variables showed a significant anticorrelation between chloride and body mass index in the [A238V;F508del]/other mutation group. In conclusion, the complex allele [A238V;F508del] seems to be associated with less general complications than in the control groups, on the other hand possibly giving a worse pulmonary phenotype and higher systemic/local inflammatory response. These findings have implications for the correct recruitment and clinical response of F508del patients in the clinical trials testing the new etiological drugs for cystic fibrosis.

Comportamiento del Helio en estrellas químicamente peculiares

NASA Astrophysics Data System (ADS)

Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.

Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de

Misura de Massa e Larghezza degli Stati $$x_1$$ e $$x_2$$ del Charmonio Formati in Interazioni $$p - \\bar{p}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pallavicini, Marco

1995-01-01

Oggetto di questa tesi è la misura di alcune caratteristiche fisiche ( massa, larghezza, e larghezza parziale in p - p) degli stati 3 Pi e 3 A del charmonio, - overo del sistema legato di un quark "charm" e del suo antiquark-, nell'ambito dell'esperimento E-760, installato nell'accumulatore di antiprotoni del Fermilab (U.S.A).

Archivo de placas astrométricas del Observatorio de La Plata

NASA Astrophysics Data System (ADS)

di Sisto, R.; Orellana, R. B.

Se ha realizado una base de datos con las placas fotográficas obtenidas con el Astrográfico del Observatorio de La Plata. Se han clasificado un total de 3000 placas obtenidas para asteroides y cometas. El acceso a la base de datos se hará por FTP y la misma contendrá la siguiente información: fecha y tiempo de exposición, coordenadas del centro de placa, tipo de emulsión fotográfica, estado de la placa, objeto fotografiado.

Gonadal dysgenesis, Turner syndrome with 46,XX,del(18p)3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Telvi, L.; Ion, R.; Bernheim, A.

1994-09-01

The authors report a case of a female infant with gonadal dysgenesis, clinical features of Turner syndrome and a de novo del(18p). The factors controlling gonadal dysgenesis and Turner syndrome are unknown to date. The genes involved could be located not only on X chromosome but also on autosomes. The present case suggests that one of these genes is situated on the short arm of chromosome 18. We conclude that patients with del(18p) syndrome should be evaluated for gonadal dysgenesis.

Mejoras en el apuntado del telescopio de 2,15 mts de CASLEO

NASA Astrophysics Data System (ADS)

Aballay, J. L.; Casagrande, A. R.; Pereyra, P. F.; Marún, A. H.

Con el objeto de optimizar el funcionamiento del telescopio de 2,15 mts. de CASLEO, se están eliminando los motores de calar, de guía y mecánica asociada. Para ésto, se están diseñando dos electrónicas que gobernarán, solamente, el motor de slew y el de tracking. Con el control del motor de slew se realizarán las funciones de slew y calar, controlando desde una PC la placa que maneja las rampas de velocidad. De este modo, el movimiento será programado y por lo tanto, más suave y preciso. Con el control del motor de tracking, a través de un generador de frecuencias programable desde una PC, se proveerá los movimientos necesarios para el tracking y guía.

Sulfate Deposition in Regolith Exposed in Trenches on the Plains Between the Spirit Landing Site and Columbia Hills in Gusev Crater, Mars

NASA Technical Reports Server (NTRS)

Wang, Alian; Haskin, L. A.; Squyres, S. W.; Arvidson, R.; Crumpler, L.; Gellert, R.; Hurowitz, J.; Schroeder, C.; Tosca, N.; Herkenhoff, K.

2005-01-01

During its exploration within Gusev crater between sol 01 and sol 158, the Spirit rover dug three trenches (Fig. 1) to expose the subsurface regolith [1, 2, 9]. Laguna trench (approx. 6 cm deep, approx.203 m from the rim of Bonneville crater) was dug in Laguna Hollow at the boundary of the impact ejecta from Bonneville crater and the surrounding plains. The Big Hole trench (approx. 6-7 cm deep) and The Boroughs trench (approx. 11 cm deep) were dug in the plains between the Bonneville crater and the Columbia Hills (approx.556 m and approx.1698 m from the rim of Bonneville crater respectively). The top, wall and floor regolith of the three trenches were investigated using the entire set of Athena scientific instruments [10].

Wiggling Its Way to Discovery

NASA Technical Reports Server (NTRS)

2004-01-01

This image shows the Mars Exploration Rover Spirit's view from its new location inside the shallow depression dubbed 'Laguna Hollow.' To get a better look at the soil making up the hollow, Spirit drove forward a bit, wiggled its wheels, then turned and backed up. The result - a scrape on the floor and a clod of dirt stuck on one of Spirit's wheels - told scientists that the soil is sticky and reminiscent of that observed at the airbag drag mark nicknamed 'Magic Carpet.' Spirit will further investigate this disturbed patch of soil with its robotic arm beginning today (Feb. 19, 2004). It will also dig a trench at 'Laguna Hollow' with one of its wheels. This fish-eye image was taken by the rover's hazard-avoidance camera.

[Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

PubMed

Álvarez, Ivón

2016-01-01

In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal.

Electromagnetically Inferred Structure of the Caja del Rio Plateau, New Mexico

NASA Astrophysics Data System (ADS)

Layton, M. E.; Speed, C.; Shukla, M.; Vila, A.; Chon, E.; Kitamikado, C.; Feucht, D. W.; Bedrosian, P.; Pellerin, L.

2016-12-01

Magnetotelluric (MT) and transient electromagnetic (TEM) data were acquired by students from the Summer of Applied Geophysical Experience (SAGE) to construct structural models in and around the Caja del Rio Plateau, New Mexico. The Caja del Rio is located on the La Bajada-Jemez constriction that separates the Española and Santa Domingo basins in the Rio Grande Rift. The Rio Grande Rift, the result of tectonic extensional forces, extends approximately north-south across northern New Mexico. MT data collected in 2016 were merged with that from previous years to make up an 11 km north line and a 16 km south line extending from the west side of the Caja Del Rio to the east off the plateau in the Old Buckman Road area. The resistivity distributions revealed in one-dimensional (1-D) and two-dimensional (2-D) inverse models show some robust features. Models of the north are interpreted as a top resistive layer (<500m) of Tertiary volcanoclastic rock, to a central conductive layer (600-200m) of Mesozoic and Paleozoic sediments of the Santa Fe group to crystalline basement rock. Models for the south line show low resistivity for the first 3 to 5 km and then transitions into higher resistivity values consistent with the models for the north line. At a period of 100 seconds induction arrows (Parkinson's convention) point in the northwest direction towards the conductive Valles Caldera. The MT models are consistent with geologic interpretations of the stratigraphic units. In addition, models disclose an additional conductive layer below the basement that we interpret as the mid-crustal conductor. Transient electromagnetic (TEM) data were collected in seven locations atop the Caja del Rio plateau in an attempt to identify the basal contact of the Cerros del Rio volcanic field, which, in turn, allow for the thickness of these basaltic and andesitic deposits to be mapped across the plateau. One-dimensional inverse models produced from the TEM data were aligned and interpreted

Field Measurements of Respiratory Del13CO2 and Photodegradation

NASA Astrophysics Data System (ADS)

van Asperen, H.; Sabbatini, S.; Nicolini, G.; Warneke, T.; Papale, D.; Notholt, J.

2014-12-01

Carbon decomposition dynamics have been studied in a variety of ecosystems and its variation can mostly be explained in terms of environmental variables (e.g. temperature and precipitation). However, carbon dynamics in arid, water limited regions have shown to be very different and are still largely unknown. Several studies have indicated the importance of photodegradation, the direct breakdown of organic matter by sunlight, in these arid regions. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure concentrations of CO2, CH4, N2O, CO as well as del13C in CO2. The FTIR was connected to 2 different flux measurement systems: a Flux Gradient system and 2 flux chambers, providing a continuous data set of gas concentrations and biosphere-atmosphere gas fluxes at different heights and scales. Field measurements showed photodegradation induced carbon fluxes. Also, respiratory del13CO2 was determined by use of Keeling plots, and was determined to vary between -25‰ and -21‰. A clear diurnal pattern in respiratory del13CO2 was found, suggesting either different (dominant) respiratory processes between day and night or the effect of diffusive fractionation.

Ecos del Cosmos: A radio astroexperience at the Universitat de Valencia

NASA Astrophysics Data System (ADS)

Marco, E.; Ballesteros, F. J.; Ortiz-Gil, A.

2017-03-01

During the last three years Ecos del Cosmos has been a radio program dedicated to spreading astronomical hot news to the Universitat de València community and beyond, and also topics of general astronomical interest. To do this, this program by Ràdio Universitat has conducted live interviews with researchers, explored relationships of astronomy with humanities and society, performed contests and explained in a simple way the main monthly ephemerides. A version of Ecos del Cosmos was broadcasted in the Onda Cero’s summer program ''Jelo en verano''conducted by Arturo Tellez.

Pier Diego Siccardi (1880-1917) and the "Clinica del Lavoro" in the trench warfare.

PubMed

Riva, Michele Augusto; Caramella, Michela; Turato, Massimo; Cesana, Giancarlo

2017-12-14

The year 2017 marks the centenary of the death of the Italian scientist Pier Diego Siccardi (1880-1917), one of Luigi Devoto's assistants at the "Clinica del Lavoro" in Milan. To commemorate Siccardi and to describe the activities of the physicians of the "Clinica del Lavoro" during World War I. A comprehensive analysis was conducted on scientific papers written by Pier Diego Siccardi and by other physicians belonging to the Clinica del Lavoro, in the period 1915-1918. During the Great War, the Clinica del Lavoro became a military hospital, even though it indirectly maintained a role in Occupational Health, assisting women who had started to work to replace the men sent to the front. Devoto and his assistants were drafted as Army doctors, but continued their research activities while at the front; focusing on the diseases that affected the soldiers, mainly infections. Bleeding fevers and jaundice were endemic among Italian troops, but their etiology was unknown. Pier Diego Siccardi identified this syndrome as an infection caused by a spirochete, and was the first one to isolate the infectious agent. Siccardi prematurely died of the same disease as a consequence of a laboratory accident, which provided further confirmation for his research. The heroic life of Siccardi and his tragic death testify the important activities of the scientists of the "Clinica del Lavoro" in the years of the Great War.

DelPhiPKa web server: predicting pKa of proteins, RNAs and DNAs.

PubMed

Wang, Lin; Zhang, Min; Alexov, Emil

2016-02-15

A new pKa prediction web server is released, which implements DelPhi Gaussian dielectric function to calculate electrostatic potentials generated by charges of biomolecules. Topology parameters are extended to include atomic information of nucleotides of RNA and DNA, which extends the capability of pKa calculations beyond proteins. The web server allows the end-user to protonate the biomolecule at particular pH based on calculated pKa values and provides the downloadable file in PQR format. Several tests are performed to benchmark the accuracy and speed of the protocol. The web server follows a client-server architecture built on PHP and HTML and utilizes DelPhiPKa program. The computation is performed on the Palmetto supercomputer cluster and results/download links are given back to the end-user via http protocol. The web server takes advantage of MPI parallel implementation in DelPhiPKa and can run a single job on up to 24 CPUs. The DelPhiPKa web server is available at http://compbio.clemson.edu/pka_webserver. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.

PubMed

Xiang, He-ping; Geng, Xiao-ping; Ge, Wei-wei; Li, He

2011-11-01

Cell cycle checkpoint kinase 2 (CHEK2) gene has been inconsistently associated with colorectal cancer (CRC), particularly the 1100delC variant. To generate large-scale evidence on whether the CHEK2 1100delC variant is associated with CRC susceptibility we have conducted a meta-analysis. Data were collected from the following electronic databases: PubMed, Excerpta Medica Database and Chinese Biomedical Literature Database, with the last report up to November 2010. The odds ratio (OR) and its 95% confidence interval (95% CI) were used to assess the strength of association. We evaluated the contrast of carriers versus non-carriers. Meta-analysis was performed in a fixed/random effect model by using the software Review Manager 4.2. A total of six studies including 4194 cases and 10,010 controls based on the search criteria were involved in this meta-analysis. A significant association of the CHEK2 1100delC variant with unselected CRC was found (OR=2.11, 95% CI=1.41-3.16, P=0.0003). We also found an association of the CHEK2 1100delC variant with familial CRC (OR=2.80, 95% CI=1.74-4.51, P<0.0001). However, the association was not established for sporadic CRC (OR=1.45, 95% CI=0.49-4.30, P=0.50). This meta-analysis demonstrates that the CHEK2 1100delC variant may be an important CRC-predisposing gene, which increases CRC risk. Copyright © 2011. Published by Elsevier Ltd.

DelPhiForce web server: electrostatic forces and energy calculations and visualization.

PubMed

Li, Lin; Jia, Zhe; Peng, Yunhui; Chakravorty, Arghya; Sun, Lexuan; Alexov, Emil

2017-11-15

Electrostatic force is an essential component of the total force acting between atoms and macromolecules. Therefore, accurate calculations of electrostatic forces are crucial for revealing the mechanisms of many biological processes. We developed a DelPhiForce web server to calculate and visualize the electrostatic forces at molecular level. DelPhiForce web server enables modeling of electrostatic forces on individual atoms, residues, domains and molecules, and generates an output that can be visualized by VMD software. Here we demonstrate the usage of the server for various biological problems including protein-cofactor, domain-domain, protein-protein, protein-DNA and protein-RNA interactions. The DelPhiForce web server is available at: http://compbio.clemson.edu/delphi-force. delphi@clemson.edu. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

DelPhi web server v2: incorporating atomic-style geometrical figures into the computational protocol.

PubMed

Smith, Nicholas; Witham, Shawn; Sarkar, Subhra; Zhang, Jie; Li, Lin; Li, Chuan; Alexov, Emil

2012-06-15

A new edition of the DelPhi web server, DelPhi web server v2, is released to include atomic presentation of geometrical figures. These geometrical objects can be used to model nano-size objects together with real biological macromolecules. The position and size of the object can be manipulated by the user in real time until desired results are achieved. The server fixes structural defects, adds hydrogen atoms and calculates electrostatic energies and the corresponding electrostatic potential and ionic distributions. The web server follows a client-server architecture built on PHP and HTML and utilizes DelPhi software. The computation is carried out on supercomputer cluster and results are given back to the user via http protocol, including the ability to visualize the structure and corresponding electrostatic potential via Jmol implementation. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver.

Los plaguicidas y la contaminacion del medio ambiente Venezolano

USGS Publications Warehouse

Stickel, L.F.; Stickel, W.H.

1972-01-01

RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.

PubMed

Apostolou, Paraskevi; Fostira, Florentia; Papamentzelopoulou, Myrto; Michelli, Maria; Panopoulos, Christos; Fountzilas, George; Konstantopoulou, Irene; Voutsinas, Gerassimos E; Yannoukakos, Drakoulis

2015-04-01

The CHEK2 gene encodes a protein kinase that plays a crucial role in maintenance of genomic integrity and the DNA repair mechanism. CHEK2 germline mutations are associated with increased risk of breast cancer and other malignancies. From a clinical perspective, the most significant mutation identified is the c.1100delC mutation, which is associated with an approximately 25% lifetime breast cancer risk. The distribution of this mutation shows wide geographical variation; it is more prevalent in the Northern European countries and less common, or even absent, in Southern Europe. In order to estimate the frequency of the CHEK2 c.1100delC mutation in Greek breast cancer patients, we genotyped 2,449 patients (2,408 females and 41 males), which was the largest series ever tested for c.1100delC. The mean age of female and male breast cancer diagnosis was 49 and 59 years, respectively. All patients had previously tested negative for the Greek BRCA1 founder and recurrent mutations. The CHEK2 c.1100delC mutation was detected in 0.16% (4 of 2,408) of females, all of whom were diagnosed with breast cancer before the age of 50 years. Only one c.1100delC carrier was reported with breast cancer family history. The present study indicates that the CHEK2 c.1100delC mutation does not contribute substantially to hereditary breast cancer in patients of Greek descent. Copyright © 2015 Elsevier Inc. All rights reserved.

Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations

PubMed Central

Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan

2013-01-01

The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ∼2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5 MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ∼5 MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750–1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ∼650 years ago, and into the Iraqi–Jewish community ∼450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews. PMID:22763381

Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome

PubMed Central

Fan, Guang Yao; Ye, Yi; Hou, Yi Ping

2016-01-01

Detecting population structure and estimating individual biogeographical ancestry are very important in population genetics studies, biomedical research and forensics. Single-nucleotide polymorphism (SNP) has long been considered to be a primary ancestry-informative marker (AIM), but it is constrained by complex and time-consuming genotyping protocols. Following up on our previous study, we propose that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures. A validation study for the X chromosome Multi-InDel marker (X-Multi-InDel) as a novel AIM was conducted. Genetic polymorphisms and genetic distances among three Chinese populations and 14 worldwide populations obtained from the 1000 Genomes database were analyzed. A Bayesian clustering method (STRUCTURE) was used to discern the continental origins of Europe, East Asia, and Africa. A minimal panel of ten X-Multi-InDels was verified to be sufficient to distinguish human ancestries from three major continental regions with nearly the same efficiency of the earlier panel with 21 insertion-deletion AIMs. Along with the development of more X-Multi-InDels, an approach using this novel marker has the potential for broad applicability as a cost-effective tool toward more accurate determinations of individual biogeographical ancestry and population stratification. PMID:27535707

75 FR 14463 - Notice of Inventory Completion: U.S. Department of the Interior, Bureau of Indian Affairs...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

..., New Mexico; Pueblo of Isleta, New Mexico; Pueblo of Picuris, New Mexico; Pueblo of Pojoaque, New..., New Mexico; Pueblo of Laguna, New Mexico; Pueblo of Nambe, New Mexico; Pueblo of Picuris, New Mexico...

[The Revista Médica del IMSS in the 2017 Healthcare Book Fair].

PubMed

Ramiro-H, Manuel; Acosta-Pérez, L; Cruz-Aranda, J E; García-Damián, J J; Miguel-Reyes, R; González-Martínez, R

2017-01-01

On August, the second edition of the Healthcare Book Fair took place, sponsored by the Facultad de Medicina of UNAM. Again, the Revista Médica del Instituto Mexicano del Seguro Social participated with a stand where we promoted it, talked about the different indexes where our journal is included, explained its objective and scope, and finally talked about its nature as an open access journal, which is aimed to the clinical staff of the different health institutions of our country.

Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

NASA Astrophysics Data System (ADS)

Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

[La Medicina del Lavoro: 100 volumes].

PubMed

Zocchetti, C

2009-01-01

With these pages La Medicina del Lavoro starts its 100th volume, so we have yet another historical occasion to celebrate the oldest occupational health journal in the world that is still publishing. Over the last few years we have had many occasions to celebrate, for example several anniversaries of the Journal (the 80th volume in 1989, 90 years in 1992, 100 years in 2001); the centenary of the foundation of the Clinica del Lavoro "Luigi Devoto" of Milan in 2001; the celebration of the 300 years' anniversary of the publication of De Morbis Artificum Diatriba by Bernardino Ramazzini, and we obviously hope to continue for many years to come in this positive outlook. One hundred volumes makes for a very large collection, with the highs and lows ofthe Journal's history (here we mean the variations in number of pages and physical size of the Journal). It is thanks to the Editors-in-chief(there have been very few so we can cite them all: Luigi Devoto, 1901-1936; Luigi Preti, 1936-1941; Enrico Vigliani, 1943-1992; e Vito Foà, 1992 to the present); the contributors who in various ways and with varying degrees of commitment but always with an exceptional personal participation, that it has been possible to reach 100 volumes, starting with C. Moreschi who, along with Luigi Devoto, was the first and sole editor at the Journal's foundation; up to the present extended and impressive editorial board; the printers (from the first. Tipografia Cooperativa, Via dei Molini in Pavia, to the latest: Casa Editrice Mattioli in Fidenza); the sponsors, including the most evident who, via advertising (rather limited as a matter offact), directly gave information about themselves, but also those who have often been or are behind the scenes, ensuring fundamental support which is not visible; content. articles, news, events, reports, ideas, opinions, photographs, tables, numbers... etc, which are really impossible to sum up. But the true collection which, for obvious reasons, cannot be

Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

NASA Astrophysics Data System (ADS)

Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones δ<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

PubMed Central

Stefano, Daniela De; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; Gregorio, Fabiola De; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; Rosa, Giuseppe De; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

2014-01-01

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in CftrF508del homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation. PMID:25350163

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

PubMed

De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

2014-01-01

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

Screening for F508del as a first step in the molecular diagnosis of cystic fibrosis.

PubMed

Marson, Fernando Augusto de Lima; Bertuzzo, Carmen Silvia; Ribeiro, Maria Ângela Gonçalves de Oliveira; Ribeiro, Antônio Fernando; Ribeiro, José Dirceu

2013-01-01

To determine the relevance of screening for the F508del mutation of the cystic fibrosis transmembrane conductance regulator gene as a first step in the genetic diagnosis of cystic fibrosis (CF) by associating the genotype with various clinical variables. We evaluated 180 CF patients regarding the F508del mutation. The clinical data were obtained from the medical records of the patients and from interviews with their parents or legal guardians. Of the 180 patients studied, 65 (36.1%) did not carry the F508del mutation (group 0 [G0]), 67 (37.2%) were F508del heterozygous (G1), and 48 (26.7%) were F508del homozygous (G2). All three groups showed associations with the clinical variables. Homozygosis was associated with younger patients, younger age at CF diagnosis, and younger age at the first isolation of Pseudomonas aeruginosa (PA), as well as with higher prevalence of pancreatic insufficiency (PI) and non-mucoid PA (NMPA) colonization. In comparison with G1+G2 patients, G0 patients were older; first experienced clinical symptoms, digestive disease, and pulmonary disease at an older age; were older at CF diagnosis and at first PA isolation; and had a lower prevalence of PI and meconium ileus, as well as of colonization by NMPA, mucoid PA, and Burkholderia cepacia. In G1 patients, values were intermediate for age at CF diagnosis; age at first PA isolation, first pulmonary symptoms, and first clinical manifestations; MPA colonization; and OR for PI. The identification of F508del in 63.9% of the patients studied showed that this can be a useful tool as a first step in the genetic diagnosis of CF. The F508del genotype was associated with clinical severity of the disease, especially with the variables related to CF onset.

Seismic influence in the Quaternary uplift of the Central Chile coastal margin, preliminary results.

NASA Astrophysics Data System (ADS)

Valdivia, D.; del Valle, F.; Marquardt, C.; Elgueta, S.

2017-12-01

In order to quantify the influence of NW striking potentially seismogenic normal faults over the longitudinal variation of the Central Chile Coastal margin uplift, we measured Quaternary marine terraces, which represent the tectonic uplift of the coastal margin. Movement in margin oblique normal faults occurs by co-seismic extension of major subduction earthquakes and has occurred in the Pichilemu fault, generating a 7.0 Mw earthquake after the 2010 8.8 Mw Maule earthquake.The coastal area between 32° and 34° S was selected due to the presence of a well-preserved sequence of 2 to 5 Quaternary marine terraces. In particular, the margin oblique normal NW-trending, SW-dipping Laguna Verde fault, south of Valparaiso (33° S) puts in contact contrasting morphologies: to the south, a flat coast with wide marine terraces is carved in both, Jurassic plutonic rocks and Neogene semi-consolidated marine sediments; to the north, a steeper scarp with narrower marine terraces, over 120 m above the corresponding ones in the southern coast, is carved in Jurassic plutonic rocks.We have collected over 6 months microseimic data, providing information on seismic activity and underground geometry of the Laguna Verde fault. We collected ca. 100 systematic measurements of fringes at the base of paleo coastal scarps through field mapping and a 5 m digital elevation model. These fringes mark the maximum sea level during the terrace's carving.The heights of these fringes range between 0 and 250 masl. We estimate a 0.7 mm/yr slip rate for the Laguna Verde fault based on the height difference between corresponding terraces north- and southward, with an average uplift rate of 0.3 mm/yr for the whole area.NW striking normal faults, besides representing a potential seismic threat to the near population on one of the most densely populated areas of Chile, heavily controls the spatial variation of the coastal margin uplift. In Laguna Verde, the uplift rate differs more than three times northward

Hydrogeochemical exploration of geothermal prospects in the Tecuamburro Volcano region, Guatemala

USGS Publications Warehouse

Janik, C.J.; Goff, F.; Fahlquist, L.; Adams, A.I.; Alfredo, Roldan M.; Chipera, S.J.; Trujillo, P.E.; Counce, D.

1992-01-01

Chemical and isotopic analyses of thermal and nonthermal waters and of gases from springs and fumaroles are used to evaluate the geothermal potential of the Tecuamburro Volcano region, Guatemala. Chemically distinct geothermal surface manifestations generally occur in separate hydrogeologic areas within this 400 km2 region: low-pressure fumaroles with temperatures near local boiling occur at 1470 m elevation in a sulfur mine near the summit of Tecuamburro Volcano; non-boiling acid-sulfate hot springs and mud pots are restricted to the Laguna Ixpaco area, about 5 km NNW of the sulfur mine and 350-400 m lower in elevation; steam-heated and thermal-meteoric waters are found on the flanks of Tecuamburro Volcano and several kilometers to the north in the andesitic highland, where the Infernitos fumarole (97??C at 1180 m) is the primary feature; neutral-chloride hot springs discharge along Rio Los Esclavos, principally near Colmenares at 490 m elevation, about 8-10 km SE of Infernitos. Maximum geothermometer temperatures calculated from Colmenares neutral-chloride spring compositions are ???180??C, whereas maximum subsurface temperatures based on Laguna Ixpaco gas compositions are ???310??C. An exploration core hole drilled to a depth of 808 m about 0.3 km south of Laguna Ixpaco had a bottom-hole temperature of 238??C but did not produce sufficient fluids to confirm or chemically characterize a geothermal reservoir. Hydrogeochemical data combined with regional geologic interpretations indicate that there are probably two hydrothermal-convection systems, which are separated by a major NW-trending structural boundary, the Ixpaco fault. One system with reservoir temperatures near 300??C lies beneath Tecuamburro Volcano and consists of a large vapor zone that feeds steam to the Laguna Ixpaco area, with underlying hot water that flows laterally to feed a small group of warm, chloriderich springs SE of Tecuamburro Volcano. The other system is located beneath the Infernitos

A 150-year record of polycyclic aromatic compound (PAC) deposition from high Andean Cajas National Park, southern Ecuador.

PubMed

Bandowe, Benjamin A Musa; Fränkl, Lea; Grosjean, Martin; Tylmann, Wojciech; Mosquera, Pablo V; Hampel, Henrietta; Schneider, Tobias

2018-04-15

The temporal profiles of polycyclic aromatic compounds (PACs) in lake sediments reflect past changes in emissions, transport and deposition of these pollutants and, thus, record natural and anthropogenic processes. We document fluxes of PACs [(polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs) and azaarenes (AZAs)] deposited in two tropical high-altitude lakes in the Cajas National Park (Ecuadorian Andes, 2°50'S, 79°10'W). In remote and high elevation Laguna Fondococha (4130m a.s.l.), the temporal fluxes of OPAHs and AZAs were similar to those of PAHs suggesting similar sources. A significant increase of PAC deposition after the 1950s reflects Ecuador's economic development. PAH fluxes were relatively low (∑27PAHs (without retene and perylene): 0.86-11.21ngcm -2 yr -1 ) with a composition pattern typical for long-range atmospheric transport (high 9-fluorenone/fluorene ratios) and biomass burning (30% low molecular weight PAHs). PAHs diagnostic of high temperature combustion (industry, traffic) make up 20-25% of total PAHs. Perylene concentrations increase linearly with increasing sediment depth suggesting diagenetic in-situ production. At lower elevations (Laguna Llaviucu, 3140m a.s.l.) and closer to urban areas, PAC fluxes in the past decades were 4-5 times higher than in the remote high-elevation lake. Laguna Llaviucu also showed higher concentrations of high molecular weight pyrogenic PAHs and a greater diversity of AZAs. Individual OPAHs and AZAs reflect mainly combustion activities. In Laguna Llaviucu, which is at a lower elevation (3140m a.s.l.) and closer to the city, molecular ratios suggest short-range atmospheric transport and deposition of PACs. A very foggy climate (170 rainy days per year) with the precipitation maximum at 3500m removes PACs very efficiently (by wet deposition) from the atmosphere at very short distances from emission sources. This partly explains why L. Llaviucu shows higher fluxes of PACs than the higher elevation L

Identificación de los miembros del cúmulo NGC 2516

NASA Astrophysics Data System (ADS)

de Elía, G. C.; Orellana, R. B.

El cúmulo abierto NGC 2516 (α = 7h 58m y δ = -60o 45') tiene una edad de, aproximadamente, 150 Myr. El análisis de este sistema es particularmente importante en el Hemisferio Sur debido a su abundancia de estrellas peculiares y muy estudiado aplicando técnicas fotométricas, pero muy poco analizado desde el punto de vista astrométrico. A partir de una placa obtenida en el Observatorio Astronómico de La Plata y observaciones más actuales, nos hemos abocado al estudio de los movimientos propios de este cúmulo con el fin de determinar la pertenencia al mismo de las estrellas del campo de dicho cúmulo. Luego de llevar a cabo la determinación de los movimientos propios de todas las estrellas a partir de las posiciones obtenidas de la placa existente en el Observatorio de La Plata de 1914 y leídas con la MAMA en París, las observaciones realizadas con el círculo meridiano de San Fernando que se encuentra en el Observatorio Félix Aguilar de San Juan y las posiciones existentes en los catálogos AC 2000, Tycho, USNO y UCAC, programamos el método de Vasilevsky y Sanders para determinar la pertenencia de las estrellas de la región al cúmulo en cuestión. En un paso posterior, se realizó una modificación al método anterior para la determinación de los miembros. En esta modificación se consideró la densidad de las estrellas del cúmulo y la densidad de estrellas de campo. Esto permitió evaluar la pertenencia, no sólo a partir del movimiento propio de las estrellas, sino también a partir de la posición de las mismas con respecto al centro del cúmulo. También se consideró la dependencia de los parámetros con la magnitud. Los resultados así obtenidos fueron comparados con otras investigaciones de movimientos propios de la región del cúmulo. El movimiento propio absoluto del cúmulo fue comparado con el obtenido a partir de los catálogos estelares. Se encontró que los resultados coincidían para estrellas brillantes (magnitud más brillante que

75 FR 18086 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

..., 2009; The Hume, Mayor, City of Elk Sacramento Bee. Grove, 8401 Laguna Palms Way, Elk Grove, CA 95758... 1059). of Sacramento County 19, 2009; The Peters, Chair, (08-09-1760P). Sacramento Bee. Sacramento...

Characterization of Two Microbial Isolates from Andean Lakes in Bolivia

NASA Technical Reports Server (NTRS)

Demergasso, C.; Blamey, J.; Escudero, L.; Chong, G.; Casamayor, E. O.; Cabrol, N. A.; Grin, E. A.; Hock, A.; Kiss, A.; Borics, G.

2004-01-01

We are currently investigating the biological population present in the highest and least explored perennial lakes on earth in the Bolivian and Chilean Andes, including several volcanic crater lakes of more than 6000 m elevation, in combination of microbiological and molecular biological methods. Our samples were collected in saline lakes of the Laguna Blanca Laguna Verde area in the Bolivian Altiplano and in the Licancabur volcano crater (27 deg. 47 min S/67 deg. 47 min. W) in the ongoing project studying high altitude lakes. The main goal of the project is to look for analogies with Martian paleolakes. These Bolivian lakes can be described as Andean lakes following the classification of Chong. We have attempted to isolate pure cultures and phylogenetically characterize prokaryotes that grew under laboratory conditions. Sediment samples taken from the Licancabur crater lake (LC), Laguna Verde (LV), and Laguna Blanca (LB) were analyzed and cultured using enriched liquid media under both aerobic and anaerobic conditions. All cultures were incubated at room temperature (15 to 20 C) and under light exposure. For the reported isolates, 36 hours incubation were necessary for reaching optimal optical densities to consider them viable cultures. Ten serial dilutions starting from 1% inoculum were required to obtain a suitable enriched cell culture to transfer into solid media. Cultures on solid medium were necessary to verify the formation of colonies in order to isolate pure cultures. Different solid media were prepared using several combinations of both trace minerals and carbohydrates sources in order to fit their nutrient requirements. The microorganisms formed individual colonies on solid media enriched with tryptone, yeast extract and sodium chloride. Cells morphology was studied by optical and electronic microscopy. Rodshape morphologies were observed in most cases. Total bacterial genomic DNA was isolated from 50 ml late-exponential phase culture by using the CTAB

Modeling visibility in the Paso del Norte (PDN) Region

NASA Astrophysics Data System (ADS)

Medina Calderon, Richard

Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts on air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Region to obtain information of the type of aerosol particles present in the Region. The Single Scattering Albedo has also been retrieved using this methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Region. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso Del Norte Region.

Highly preferential association of NonF508del CF mutations with the M470 allele.

PubMed

Ciminelli, B M; Bonizzato, A; Bombieri, C; Pompei, F; Gabaldo, M; Ciccacci, C; Begnini, A; Holubova, A; Zorzi, P; Piskackova, T; Macek, M; Castellani, C; Modiano, G; Pignatti, P F

2007-01-01

On the basis of previous findings on random individuals, we hypothesized a preferential association of CF causing mutations with the M allele of the M470V polymorphic site of the CFTR gene. We have determined the M/V-CF mutation haplotype in a series of 201 North East Italian and 73 Czech CF patients who were not F508del homozygotes, as F508del was already known to be fully associated with the M allele. Out of 358 not F508del CF genes, 84 carried the V allele and 274 the less common M allele. In the N-E Italian population, MM subjects have a risk of carrying a CF causing mutation 6.9x greater than VV subjects when F508del is excluded and 15.4x when F508del is included. In the Czech population a similar, although less pronounced, association is observed. Besides the possible biological significance of this association, the possibility of exploiting it for a pilot screening program has been explored in a local North East Italian population for which CF patients were characterized for their CF mutation. General M470V genotyping followed by common CF mutation screening limited to couples in which each partner carries at least one M allele would need testing only 39% of the couples, which contribute 89% of the total risk, with a cost benefit.

Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

PubMed Central

Hogervorst, Frans; van Hien, Richard; Cornelissen, Sten; Broeks, Annegien; Adank, Muriel A.; Meijers, Hanne; Waisfisz, Quinten; Hollestelle, Antoinette; Schutte, Mieke; van den Ouweland, Ans; Hooning, Maartje; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Antoniou, Antonis C.; Arndt, Volker; Bermisheva, Marina; Bogdanova, Natalia V.; Bolla, Manjeet K.; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Burwinkel, Barbara; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Dunning, Alison M.; Fasching, Peter A.; Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Galle, Eva; García-Closas, Montserrat; Giles, Graham G.; Haeberle, Lothar; Hall, Per; Hillemanns, Peter; Hopper, John L.; Jakubowska, Anna; John, Esther M.; Jones, Michael; Khusnutdinova, Elza; Knight, Julia A.; Kosma, Veli-Matti; Kristensen, Vessela; Lee, Andrew; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Margolin, Sara; Meindl, Alfons; Milne, Roger L.; Muranen, Taru A.; Newcomb, Polly A.; Offit, Kenneth; Park-Simon, Tjoung-Won; Peto, Julian; Pharoah, Paul D.P.; Robson, Mark; Rudolph, Anja; Sawyer, Elinor J.; Schmutzler, Rita K.; Seynaeve, Caroline; Soens, Julie; Southey, Melissa C.; Spurdle, Amanda B.; Surowy, Harald; Swerdlow, Anthony; Tollenaar, Rob A.E.M.; Tomlinson, Ian; Trentham-Dietz, Amy; Vachon, Celine; Wang, Qin; Whittemore, Alice S.; Ziogas, Argyrios; van der Kolk, Lizet; Nevanlinna, Heli; Dörk, Thilo; Bojesen, Stig; Easton, Douglas F.

2016-01-01

Purpose CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. Patients and Methods CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies. Results Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center–based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10−20). The OR was higher for estrogen receptor (ER)–positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10−21]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10−4). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom. Conclusion These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into

Estudio fenomenologico del conocimiento curricular y conocimiento de contenido en maestros de matematica a nivel secundario

NASA Astrophysics Data System (ADS)

Cardona Tomassini, Ivan Javier

En esta investigacion se estudio el fenomeno del conocimiento de contenido y el conocimiento curricular de maestros de matermaticas y como estos dos componentes se reflejan en su conocimiento pedagogico del contenido. El conocimiento de contenido es el conocimiento que tienen los maestros de los contenidos de una disciplina y sobre la estructura de su organizacion (Shulman, 1986). El conocimiento curricular es el conocimiento que los maestros poseen sobre los componentes de un curriculo disenado para ensenar un topico de una materia especifica a un nivel particular, la variedad de instrumentos instruccionales disponibles para implementar el mismo y como utilizar los instrumentos curriculares disponibles (Ball & Bass, 2003; Choppin, 2009; Hill, Rowan, & Ball, 2005). Este estudio se enmarca en el paradigma cualitativo, teniendo como diseno el estudio fenomenologico (Lucca y Berrios, 2009; McMillan, 2004). Los participantes fueron seis maestros de matermaticas del nivel superior (10mo a 12mo grado). Al momento de la investigacion los participantes ensenaban en escuelas publicas o privadas de Puerto Rico. Para recolectar la informacion se utilizo un grupo focal en donde los maestros resolvieron seis ejercicios matematicos y posteriormente reflexionaron en forma grupal sobre las soluciones. Tambien se realizo un analisis de documentos de planificacion y se llevaron a cabo entrevistas semiestructuradas. Se exploraron los contenidos relacionados a la ecuacion de una recta, rectas verticales y horizontales, suma y multiplicacion de polinomios, resolucion de ecuaciones cuadraticas y distancia entre dos puntos del plano cartesiano. Los resultados muestran que los participantes tienen dominio procesal de los contenidos correspondientes a las rectas verticales y horizontales, la suma y multiplicacion de polinomios, el calculo distancia entre dos puntos del plano cartesiano. Sin embargo, se noto cierta dificultad en la explicacion conceptual de los contenidos relacionados a la

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.

PubMed

Schmidt, Marjanka K; Hogervorst, Frans; van Hien, Richard; Cornelissen, Sten; Broeks, Annegien; Adank, Muriel A; Meijers, Hanne; Waisfisz, Quinten; Hollestelle, Antoinette; Schutte, Mieke; van den Ouweland, Ans; Hooning, Maartje; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Antoniou, Antonis C; Arndt, Volker; Bermisheva, Marina; Bogdanova, Natalia V; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Burwinkel, Barbara; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dunning, Alison M; Fasching, Peter A; Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Galle, Eva; García-Closas, Montserrat; Giles, Graham G; Haeberle, Lothar; Hall, Per; Hillemanns, Peter; Hopper, John L; Jakubowska, Anna; John, Esther M; Jones, Michael; Khusnutdinova, Elza; Knight, Julia A; Kosma, Veli-Matti; Kristensen, Vessela; Lee, Andrew; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Margolin, Sara; Meindl, Alfons; Milne, Roger L; Muranen, Taru A; Newcomb, Polly A; Offit, Kenneth; Park-Simon, Tjoung-Won; Peto, Julian; Pharoah, Paul D P; Robson, Mark; Rudolph, Anja; Sawyer, Elinor J; Schmutzler, Rita K; Seynaeve, Caroline; Soens, Julie; Southey, Melissa C; Spurdle, Amanda B; Surowy, Harald; Swerdlow, Anthony; Tollenaar, Rob A E M; Tomlinson, Ian; Trentham-Dietz, Amy; Vachon, Celine; Wang, Qin; Whittemore, Alice S; Ziogas, Argyrios; van der Kolk, Lizet; Nevanlinna, Heli; Dörk, Thilo; Bojesen, Stig; Easton, Douglas F

2016-08-10

CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies. Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom. These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up. © 2016

Oak Canyon Action Memo

EPA Pesticide Factsheets

This memorandum requests approval for a time-critical removal action at the 27 residential properties that compose the Oak Canyon Site located in the Village of Paguate, Pueblo of Laguna, near Cibola County, New Mexico.

Effect of the F508del genotype on outcomes of endoscopic sinus surgery in children with cystic fibrosis.

PubMed

Do, Bao Anh Julie; Lands, Larry C; Saint-Martin, Christine; Mascarella, Marco A; Manoukian, John J; Daniel, Sam J; Nguyen, Lily H P

2014-07-01

Numerous authors have sought to describe genotype-phenotype correlations in cystic fibrosis (CF), notably to pancreatic insufficiency and lung disease. However, few studies have focused on the association between the F508del genotype and response to sinus surgery. The objective of this study is to assess the effect of the F508del genotype on sinonasal disease severity and outcomes following functional endoscopic sinus surgery (FESS) in a pediatric population. A retrospective chart review of 153 children with CF seen at a tertiary care pediatric hospital from 1995 to 2008 was performed. Patients were classified into one of three groups according to F508del genotype, either as homozygous, heterozygous or not carrying a F508del mutation. The sinonasal disease phenotype of the three groups was compared based on clinical and radiological findings, extent of endoscopic sinus surgery and rate of revision surgery. The relationship between the F508del genotype and pancreatic insufficiency was confirmed (p<0.05). There was no association between the F508del genotype and increased need for FESS (p=0.75). Moreover, no association was established between F508del homozygosity and presence of nasal polyps, Lund-Mackay score, extent of surgery or length of postoperative hospitalization. The rates of revision surgery did not differ significantly among the three genotypes analyzed (p=0.59). There is no clear association between the F508del genotype and an increased need for FESS, extent of surgery, or revision surgery. Given the phenotypic variability of sinonasal disease in patients with CF, a prospective study is needed to better understand outcomes following FESS and the contribution of gene modifiers to this effect. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

[Seventy years of medicine in the Instituto Mexicano del Seguro Social].

PubMed

Fajardo-Ortiz, Guillermo

2014-01-01

The purpose of these lines is to remember and refer some of the historical landmarks in the evolution of the medical services of the Instituto Mexicano del Seguro Social (IMSS, according to its initials in Spanish) since it was founded, in 1943. We also want to bring to the reader's attention that the dimensions and impacts on health that IMSS has achieved, throughout its history, have strengthened the citizenship, as well as social sustainability. Also, those impacts have determined the creation and the reinforcement of human capital in México. Throughout this concise balance, all the controversy surrounding the foundation of the Institute is being recalled (the protest in the Mexico City Zócalo, or the attack to an hospital in San Ángel -a neighborhood located in the Southwest of Mexico City-), as well as the way the IMSS incorporated several words into the vocabulary of Mexicans. We also remember the previous antecedent of the Revista Médica del Instituto Mexicano del Seguro Social, as well as the Revista de Enfermería, and the emblematic Archives of Medical Research. The IMSS has 70 years of achievements, seven decades covered.

Medición de densidades medias de meteoritos: test del método de inmersión

NASA Astrophysics Data System (ADS)

Steren, G.

Se evaluó una técnica simple para medir las densidades medias de meteoritos, basada en el Método de Arquímedes y que utiliza cuentas de vidrio de 40μ en lugar de un fluído esto presenta la ventaja de no ser intrusivo ni químicamente reactivo (D.Britt and G.Consolmagno, 1996, B.A.A.S.28,1106). El estudio, realizado en junio de este año por participantes de la VI Escuela de Verano del Observatorio del Vaticano, empleó 37 muestras de la colección del Observatorio del Vaticano, de las cuales 26 eran Condritas, 1 Pallasita y 1 Howardita; algunas de ellas ya habian sido estudiadas por otras técnicas aunque también se incluyeron muestras no estudiadas anteriormente.

A chemical corrector modifies the channel function of F508del-CFTR.

PubMed

Kim Chiaw, Patrick; Wellhauser, Leigh; Huan, Ling Jun; Ramjeesingh, Mohabir; Bear, Christine E

2010-09-01

The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing the biosynthetic defect in F508del-CFTR, thereby permitting its functional expression at the cell surface. The mechanism of action of chemical correctors remains unclear, but it has been suggested that certain correctors [including 4-cyclohexyloxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-325)] may act to promote trafficking by interacting directly with the mutant protein. To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hydroxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-186)], caused a modest but significant inhibition of cAMP-mediated halide flux. Furthermore, VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR in our ATPase activity assay, an effect that may account for the decrease in channel activity by temperature-rescued F508del-CFTR. These findings suggest that biosynthetic rescue mediated by VRT-325 may be conferred (at least in part) by direct modification of the structure of the mutant protein, leading to a decrease in its ATP-dependent conformational dynamics. Therefore, the challenge for therapy discovery will be the design of small molecules that bind to promote biosynthetic maturation of the major mutant without compromising its activity in

DK phocomelia phenotype (von Voss-Cherstvoy syndrome) caused by somatic mosaicism for del(13q).

PubMed

Bamforth, J S; Lin, C C

1997-12-31

DK phocomelia (von Voss-Cherstvoy syndrome) is a rare condition characterized by radial ray defects, occipital encephalocoele, and urogenital abnormalities. Lubinsky et al. [1994: Am J Med Genet 52:272-278] pointed out similarities between this and the del(13q) syndrome. To date, all reported cases of DK phocomelia have been apparently normal chromosomally. We report on a case of DK phocomelia in which the proposita had normal lymphocyte chromosomes, but was mosaic in fibroblasts for del(13)(q12). Fibroblast chromosomes studies on other cases of DK phocomelia have not been reported: this raises the possibility that some cases of DK phocomelia may be somatic mosaics for del(13)(q12).

Cirugía de los trastornos del comportamiento: el estado del arte

PubMed Central

Yampolsky, Claudio; Bendersky, Damián

2014-01-01

Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases.

PubMed

Adank, Muriel A; Verhoef, Senno; Oldenburg, Rogier A; Schmidt, Marjanka K; Hooning, Maartje J; Martens, John W M; Broeks, Annegien; Rookus, Matti; Waisfisz, Quinten; Witte, Birgit I; Jonker, Marianne A; Meijers-Heijboer, Hanne

2013-05-01

The CHEK2∗1100delC mutation confers a relative risk of two for breast cancer (BC) in the general population. This study aims to explore the excess cancer risk due to the CHEK2∗1100delC mutation within a familial non-BRCA1/2 breast cancer setting. Cancer incidences were compared between first degree relatives of 107 familial breast cancer patients positive for the CHEK2∗1100delC mutation (CHEK2 positive families) and first degree relatives of 314 familial breast cancer patients without the CHEK2∗1100delC mutation (CHEK2 negative families). All families were derived from the same pool of familial non-BRCA1/2 breast cancer families (n=2554). Medical information of 2188 first degree relatives of these families was analysed for cancer risk. CHEK2∗1100delC status of relatives was unknown. Increased breast cancer risk (hazard ratio (HR) 2.0 (95% confidence interval (CI): 1.4-2.7), p<0.001) was observed in sisters of CHEK2∗1100delC positive index cases compared to sisters of CHEK2∗1100delC negative index cases. HR was 1.6 (95% CI: 1.0-2.4) for mothers of CHEK2 positive versus negative index cases (p=0.041). For second primary breast cancers HR was increased in CHEK2∗1100delC positive index cases (HR 2.1, 95% CI: 1.3-3.3, p=0.003) and their sisters (HR 2.6, 95% CI: 1.1-6.1, p=0.025). There is an excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive non-BRCA1/2 familial breast cancer patients compared to non-CHEK2∗1100delC familial breast cancer relatives. Genotyping for the CHEK2∗1100delC mutation in a familial breast cancer setting contributes to optimal clinical surveillance in countries in which this mutation is prevalent. Carriers and female relatives are eligible for stringent breast surveillance programs. Copyright © 2013 Elsevier Ltd. All rights reserved.

Species identification in forensic samples using the SPInDel approach: A GHEP-ISFG inter-laboratory collaborative exercise.

PubMed

Alves, Cíntia; Pereira, Rui; Prieto, Lourdes; Aler, Mercedes; Amaral, Cesar R L; Arévalo, Cristina; Berardi, Gabriela; Di Rocco, Florencia; Caputo, Mariela; Carmona, Cristian Hernandez; Catelli, Laura; Costa, Heloísa Afonso; Coufalova, Pavla; Furfuro, Sandra; García, Óscar; Gaviria, Anibal; Goios, Ana; Gómez, Juan José Builes; Hernández, Alexis; Hernández, Eva Del Carmen Betancor; Miranda, Luís; Parra, David; Pedrosa, Susana; Porto, Maria João Anjos; Rebelo, Maria de Lurdes; Spirito, Matteo; Torres, María Del Carmen Villalobos; Amorim, António; Pereira, Filipe

2017-05-01

DNA is a powerful tool available for forensic investigations requiring identification of species. However, it is necessary to develop and validate methods able to produce results in degraded and or low quality DNA samples with the high standards obligatory in forensic research. Here, we describe a voluntary collaborative exercise to test the recently developed Species Identification by Insertions/Deletions (SPInDel) method. The SPInDel kit allows the identification of species by the generation of numeric profiles combining the lengths of six mitochondrial ribosomal RNA (rRNA) gene regions amplified in a single reaction followed by capillary electrophoresis. The exercise was organized during 2014 by a Working Commission of the Spanish and Portuguese-Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG), created in 2013. The 24 participating laboratories from 10 countries were asked to identify the species in 11 DNA samples from previous GHEP-ISFG proficiency tests using a SPInDel primer mix and control samples of the 10 target species. A computer software was also provided to the participants to assist the analyses of the results. All samples were correctly identified by 22 of the 24 laboratories, including samples with low amounts of DNA (hair shafts) and mixtures of saliva and blood. Correct species identifications were obtained in 238 of the 241 (98.8%) reported SPInDel profiles. Two laboratories were responsible for the three cases of misclassifications. The SPInDel was efficient in the identification of species in mixtures considering that only a single laboratory failed to detect a mixture in one sample. This result suggests that SPInDel is a valid method for mixture analyses without the need for DNA sequencing, with the advantage of identifying more than one species in a single reaction. The low frequency of wrong (5.0%) and missing (2.1%) alleles did not interfere with the correct species identification, which demonstrated the

Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors.

PubMed

Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J; de Jonge, Hugo R

2012-01-01

Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators.

CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis.

PubMed

Weischer, Maren; Heerfordt, Ida M; Bojesen, Stig E; Eigentler, Thomas; Garbe, Claus; Röcken, Martin; Hölmich, Lisbet Rosenkrantz; Schmidt, Henrik; Klyver, Helle; Bastholt, Lars; Nordestgaard, Børge G

2012-02-01

It is possible that reduced function of DNA repair and cell-cycle control genes increases the individual susceptibility to malignant melanoma. As CHEK2 is a cell-cycle master controller, we tested the hypothesis that heterozygosity for the frameshift alteration CHEK2*1100delC is associated with increased risk of malignant melanoma. First, we performed case-control studies of 1,152 Danish and 752 German individuals with malignant melanoma compared with 9,142 Danish and 3,718 German controls. Second, we performed a meta-analysis of CHEK2*1100delC and malignant melanoma, involving 2,619 cases and 17,481 controls. Third, we examined the risk of malignant melanoma associated with CHEK2*1100delC heterozygosity in an analysis stratified for sun exposure, as well as for subtype and location on the body. The odds ratios for malignant melanoma for CHEK2(*)1100del heterozygotes compared with those for noncarriers were 2.01 (95% confidence interval (CI), 1.03-3.91) in Danes, 1.42 (95% CI, 0.46-4.31) in Germans, and 1.79 (95% CI, 1.02-3.17) in Danes and Germans combined. In a meta-analysis, the odds ratio of malignant melanoma for CHEK2*1100delC heterozygotes compared with that for noncarriers was 1.81 (95% CI, 1.07-3.05). Stratifications did not alter these results. CHEK2*1100delC heterozygotes have a twofold risk of malignant melanoma compared with noncarriers.

Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.

PubMed

Iniesta, Maria D; Gorin, Michael A; Chien, Ling-Chen; Thomas, Samantha M; Milliron, Kara J; Douglas, Julie A; Merajver, Sofia D

2010-10-15

The CHEK2*1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations. The highest frequency has been described in Northern and Eastern European countries; the frequency may be much lower in North America. In this study, our aim was to determine the frequency of CHEK2*1100delC in members of breast cancer families who tested negative for a deleterious mutation in BRCA1/2 at the University of Michigan Comprehensive Cancer Center. We genotyped 102 members from 90 families for CHEK2*1100delC. Most of these families had several cases of breast cancer or ovarian cancer (or both), as well as multiple members with other cancer types in a single lineage. No CHEK2*1100delC mutations were detected in any of the 102 individuals, including 51 women diagnosed with breast cancer at an early age (<45 years), 8 women with bilateral breast cancer, 3 men with breast cancer, and 8 women with ovarian cancer. Our data are consistent with the reported very low frequency of CHEK2*1100delC mutations in North American populations (compared with Northern Europe), rendering CHEK2*1100delC such an unlikely culprit in BRCA1/2 negative families that routine testing of these families appears unwarranted. Copyright © 2010 Elsevier Inc. All rights reserved.

Mini-mastoidectomía para anastomosis hipogloso-facial con sección parcial del nervio hipogloso

PubMed Central

Campero, Álvaro; Ajler, Pablo; Socolovsky, Mariano; Martins, Carolina; Rhoton, Albert

2012-01-01

Introducción: La anastomosis hipogloso-facial es la técnica de elección para la reparación de la parálisis facial cuando no se dispone de un cabo proximal sano del nervio facial. La técnica de anastomosis mediante fresado mastoideo y sección parcial del hipogloso minimiza la atrofia lingual sin sacrificar resultados a nivel facial. Método: La porción mastoidea del nervio facial transcurre por la pared anterior de la AM, a un promedio de 18+/-3 mm de profundidad respecto de la pared lateral. Se debe reconocer la cresta supramastoidea, desde la cual se marca una línea vertical paralela al eje mayor de la AM, 1 cm por detrás de la pared posterior del CAE El fresado se comienza desde la línea medio mastoidea hasta la pared posterior del CAE. Una vez encontrado el nervio facial en el tercio medio del canal mastoideo, el mismo es seguido hacia proximal y distal. Resultados: El abordaje descripto permite acceder al nervio facial intratemporal en su porción mastoidea, y efectuar un fresado óseo sin poner en riesgo al nervio o a estructuras vasculares cercanas. Se trata de un procedimiento técnicamente más sencillo que los abordajes amplios habitualmente utilizados al hueso temporal; no obstante su uso debe ser restringido mayormente a la anastomosis hipogloso-facial. Conclusión: Esta es una técnica relativamente sencilla, que puede ser reproducida por cirujanos sin mayor experiencia en el tema, luego de su paso por el laboratorio de anatomía. PMID:23596555

Reproductive biology of the Del Norte salamander (Plethodon elongatus).

Treesearch

Clara A. Wheeler; Hartwell H. Welsh Jr.; Lisa M. Ollivier

2013-01-01

We examined seasonal reproductive patterns of the Del Norte Salamander, Plethodon elongatus, in mixed conifer and hardwood forests of northwestern California and southwestern Oregon. Seasonal size differences in reproductive structures suggested that maximum spermatogenic activity occurred during the late summer, with spermatozoa transfer to the...

New records of fishes at Isla del Coco, Costa Rica

USGS Publications Warehouse

Garrison, V.H.

1996-01-01

Isla del Coco lies at 5 degrees 32'N latitude, 87 degrees 04'W longitude and is the sole peak of the Cocos Ridge exposed above sea level. This isolated island formed approximately 2 million years ago. It rises 575 m above the surface of the sea and covers 46 km2 (Castillo et aI., 1988). Five hundred km to the NNE is Costa Rica; 630 km SSW are the Galapagos Islands; 650 km to the E is Isla Malpelo, Colombia; and approximately 8,000 km W lie the Line Islands. Costa Rica claimed Isla del Coco in 1832 and declared it a National Park in 1978. The area of the park was increased to include the adjacent waters 5 km offshore in 1984 and 25 km offshore in 1991.

26 CFR 301.7514-1 - Seals of office.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) South Texas District (Austin) Southern California District (Laguna Niguel) Southwest District (Phoenix...: Austin Cincinnati Memphis Kansas City Ogden Office of Director of Customer Service Centers in: Andover Atlanta Austin Baltimore Brookhaven Buffalo Cincinnati Cleveland Dallas Denver Fresno Indianapolis...

26 CFR 301.7514-1 - Seals of office.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) South Texas District (Austin) Southern California District (Laguna Niguel) Southwest District (Phoenix...: Austin Cincinnati Memphis Kansas City Ogden Office of Director of Customer Service Centers in: Andover Atlanta Austin Baltimore Brookhaven Buffalo Cincinnati Cleveland Dallas Denver Fresno Indianapolis...

26 CFR 301.7514-1 - Seals of office.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) South Texas District (Austin) Southern California District (Laguna Niguel) Southwest District (Phoenix...: Austin Cincinnati Memphis Kansas City Ogden Office of Director of Customer Service Centers in: Andover Atlanta Austin Baltimore Brookhaven Buffalo Cincinnati Cleveland Dallas Denver Fresno Indianapolis...

Baja Earthquake, Radar Image and Colored Height

NASA Image and Video Library

2010-04-05

The topography surrounding the Laguna Salada Fault in the Mexican state of Baja, California, is shown in this perspective view with data from NASA Shuttle Radar Topography Mission where a 7.2 earthquake struck on April 4, 2010.

The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population.

PubMed

Plonis, J; Kalniete, D; Nakazawa-Miklasevica, M; Irmejs, A; Vjaters, E; Gardovskis, J; Miklasevics, E

2015-12-01

Our objective was to determine: 1) whether the checkpoint kinase 2 ( CHEK2 ) del5395 (g.27417113-27422508 del, NC_000022.11) is a founder mutation in the Latvian population, 2) if there is an association between CHEK2 del5395 mutation and cancer risk, and 3) and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster) as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR). The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher's exact test. All p values were two-sided and the odds ratios (OR) calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32). In control groups, the del5395 mutation was most frequent (0.76%) in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer.

Seguridad del paciente en Radioterapia Intraoperatoria: Impacto de los elementos controlados por el Radiofisico

NASA Astrophysics Data System (ADS)

Tarjuelo, Juan Lopez

Introduccion: En la administracion de la radioterapia intervienen profesionales y equipos de tratamiento, por lo que existe el riesgo de error y se precisa que dicho equipamiento funcione conforme a lo esperado. A los radiofisicos les corresponde participar en las actividades de garantia o aseguramiento de la calidad, incluyendo el control de calidad de los equipos, y en la evaluacion de los riesgos asociados. La radioterapia intraoperatoria (RIO) es una tecnica radioterapica de intensificacion de dosis, altamente selectiva, dirigida a volumenes anatomicos restringidos durante el tratamiento quirurgico oncologico, basada en la administracion de una dosis absorbida alta por medio de un haz de electrones tras el examen visual directo del lecho tumoral. Como incorporar los ultimos avances en el refuerzo de la seguridad en radioterapia es una tarea ambiciosa y compleja, resulta mas concreta y de inmediata aplicacion su introduccion en la RIO. El objetivo es analizar los elementos que reducen los riesgos y aumentan la seguridad en la RIO y su dosimetria, y valorar la funcion del radiofisico en esta labor. Material y metodos: Se emplearon el planificador Radiance de GMV y el acelerador lineal de los tratamientos de RIO Elekta Precise, controlado con el verificador diario de haces Daily QA Check 1090 y medido con las camaras de ionizacion PPC 40, FC65-G y FC65-P de PTW-Freiburg, a su vez verificadas con fuentes radiactivas adecuadas de estroncio-90 modelos CDP y CDC de IBA Dosimetry. Se realizo un analisis de modos de fallo y efectos (failure mode and effect analysis, FMEA) con el fin de identificar los elementos que forman la RIO y aplicar las herramientas necesarias para la minimizacion de los riesgos y la mejora de la seguridad en la tecnica. Se estudiaron las verificaciones diarias de dicho acelerador Precise con el control estadistico de procesos (statistical process control, SPC) y se simularon intervenciones para devolverlo al estado llamado en control. El SPC

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.

PubMed

Liang, Mingming; Zhang, Yun; Sun, Chenyu; Rizeq, Feras Kamel; Min, Min; Shi, Tingting; Sun, Yehuan

2018-06-16

The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate. This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between 1100delC and breast cancer. Meta-analysis results suggested that 1100delC contributed to an increased breast cancer risk in overall populations (OR 2.89; 95% CI 2.63-3.16). Subgroup analysis found ORs of 3.13 (95% CI 1.94-5.07) for male breast cancer, 2.88 (95% CI 2.63-3.16) for female breast cancer, 2.87 (95% CI 1.85-4.47) for early-onset breast cancer, 2.92 (95% CI 2.65-3.22) for invasive breast cancer, and 3.21 (95% CI 2.41-4.29) for familial breast cancer. The sensitivity analysis suggested that results of this meta-analysis were generally robust. CHEK2*1100delC is associated with an increased risk of both female and male breast cancer.

Earth observations taken during STS-83 mission

NASA Image and Video Library

2016-08-24

STS083-749-084 (4-8 April 1997) --- Laguna Oja De Liebre, Baja, gray whale breeding ground Laguna Oja De Liebre, Baja (Scammons Lagoon) is located on the west coast in the plains of the central Baja. This lagoon and others like it along the Baja coast are used for breeding grounds for the gray whale. One group of gray whales inhabits the Sea of Okhotsk in summer, migrating south in winter then breed off southern Korea. The other summers in the Bering and Chukchi seas and travels south to winter breeding grounds along the coast of Baja California. The gray whale was hunted almost to extinction by 1925 but was placed under complete international protection and since the 1940s has increased in numbers. The white grids seen in the photo are commercial salt ponds.

Comprehensive dental services for an underserved and medically compromised population provided through a community partnership and service learning.

PubMed

Chávez, Elisa M; LaBarre, Eugene; Fredekind, Richard; Isakson, Paul

2010-01-01

The University of the Pacific, Arthur A. Dugoni School of Dentistry in San Francisco established a comprehensive dental care program at Laguna Honda Hospital, a public, skilled nursing facility. The program had three goals: (1) to provide dental students and residents an opportunity to provide oral health care for adults who were frail and medically compromised who could not come into the clinics, (2) to increase students' access to patients who needed removable prosthodontics, and (3) to fulfill Pacific's commitment to public service. Laguna Honda and Pacific pooled their resources to bring comprehensive dental care to patients who were not able to access the dental school clinics. The long-term goals are to restore and maintain the oral health of those who reside in the facility, and to educate future dentists to provide oral health care for similar populations.

[Genetic polymorphism and forensic application of 30 InDel loci of Han population in Beijing].

PubMed

Bai, Ru-Feng; Jiang, Li-Zhe; Zhang, Zhong; Shi, Mei-Sen

2013-12-01

To study the genetic diversities of 30 insertion-deletion (InDel) polymorphisms loci of Han population in Beijing, and to evaluate their forensic application, 210 unrelated healthy individuals of Han population in Beijing were investigated to determine the distributions of allele frequencies by using Investigator DIP system. The PCR products were detected with ABI 3130 XL Genetic Analyzer. Forensic parameters were calculated with relevant statistical analysis software. As a result, after the Bonferroni correction at a 95% significance level, there were no significant departures from Hardy-Weinberg equilibrium or significant linkage disequilibrium between the loci. The power of discrimination (DP) varies between 0.2690 (HLD118) and 0.6330 (HLD45), and the combined discrimination power (TDP) for the 30 InDel loci is 0.999999999985. The combined power of exclusion was 0.98771049 in trio cases (CPE(trio)) and 0.94579456 in duo cases (CPE(duo)). The parentage testing of 32 cases revealed no mutations happened to 30 InDel loci. Multiplex detection of the 30 InDel loci revealed a highly polymorphic genetic distribution in Beijing Han population, which represents a complementary tool in human identification studies, especially in challenging DNA cases.

Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene.

PubMed

Soejima, Mikiko; Agusa, Tetsuro; Iwata, Hisato; Fujihara, Junko; Kunito, Takashi; Takeshita, Haruo; Lan, Vi Thi Mai; Minh, Tu Binh; Takahashi, Shin; Trang, Pham Thi Kim; Viet, Pham Hung; Tanabe, Shinsuke; Koda, Yoshiro

2015-01-01

The haptoglobin (HP) gene deletion allele (HP(del)) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HP(del) in addition to the distribution of common HP genotypes in 293 Vietnamese. The HP(del) was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

CDC25AQ110del: A Novel Cell Division Cycle 25A Isoform Aberrantly Expressed in Non-Small Cell Lung Cancer

PubMed Central

Younis, Rania H.; Cao, Wei; Lin, Ruxian; Xia, Ronghui; Liu, Zhenqiu; Edelman, Martin J.; Mei, Yuping; Mao, Li; Ren, Hening

2012-01-01

Objective Lung cancer remains number one cause of cancer related deaths worldwide. Cell cycle deregulation plays a major role in the pathogenesis of Non-Small Cell Lung Cancer (NSCLC). CDC25A represents a critical cell cycle regulator that enhances cell cycle progression. In this study we aimed to investigate the role of a novel CDC25A transcriptional variant, CDC25AQ110del, on the regulation of the CDC25A protein, and its impact on prognosis of NSCLC patients. Methodology/Principal Findings Here we report a novel CDC25A transcript variant with codon 110 (Glutamine) deletion, that we termed CDC25AQ110del in NSCLC cells. In 9 (75%) of the 12 NSCLC cell lines, CDC25AQ110del expression accounted for more than 20% of the CDC25A transcripts. Biological effects of CDC25AQ110del were investigated in H1299 and HEK-293F cells using UV radiation, flowcytometry, cyclohexamide treatment, and confocal microscopy. Compared to CDC25Awt, CDC25AQ110del protein had longer half-life; cells expressing CDC25AQ110del were more resistant to UV irradiation and showed more mitotic activity. Taqman-PCR was used to quantify CDC25AQ110del expression levels in 88 primary NSCLC tumor/normal tissue pairs. In patients with NSCLC, Kaplan Meier curves showed tumors expressing higher levels of CDC25AQ110del relative to the adjacent lung tissues to have significantly inferior overall survival (P = .0018). Significance Here we identified CDC25AQ110del as a novel transcriptional variant of CDC25A in NSCLC. The sequence-specific nature of the abnormality could be a prognostic indicator in NSCLC patients as well as a candidate target for future therapeutic strategies. PMID:23071577

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

PubMed Central

Van Goor, Fredrick; Hadida, Sabine; Grootenhuis, Peter D. J.; Burton, Bill; Stack, Jeffrey H.; Straley, Kimberly S.; Decker, Caroline J.; Miller, Mark; McCartney, Jason; Olson, Eric R.; Wine, Jeffrey J.; Frizzell, Ray A.; Ashlock, Melissa; Negulescu, Paul A.

2011-01-01

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for proper function of the lung, pancreas, and other organs. Most patients with CF carry the F508del CFTR mutation, which causes defective CFTR protein folding and processing in the endoplasmic reticulum, resulting in minimal amounts of CFTR at the cell surface. One strategy to treat these patients is to correct the processing of F508del-CFTR with small molecules. Here we describe the in vitro pharmacology of VX-809, a CFTR corrector that was advanced into clinical development for the treatment of CF. In cultured human bronchial epithelial cells isolated from patients with CF homozygous for F508del, VX-809 improved F508del-CFTR processing in the endoplasmic reticulum and enhanced chloride secretion to approximately 14% of non-CF human bronchial epithelial cells (EC50, 81 ± 19 nM), a level associated with mild CF in patients with less disruptive CFTR mutations. F508del-CFTR corrected by VX-809 exhibited biochemical and functional characteristics similar to normal CFTR, including biochemical susceptibility to proteolysis, residence time in the plasma membrane, and single-channel open probability. VX-809 was more efficacious and selective for CFTR than previously reported CFTR correctors. VX-809 represents a class of CFTR corrector that specifically addresses the underlying processing defect in F508del-CFTR. PMID:21976485

DelPhi Web Server: A comprehensive online suite for electrostatic calculations of biological macromolecules and their complexes

PubMed Central

Sarkar, Subhra; Witham, Shawn; Zhang, Jie; Zhenirovskyy, Maxim; Rocchia, Walter; Alexov, Emil

2011-01-01

Here we report a web server, the DelPhi web server, which utilizes DelPhi program to calculate electrostatic energies and the corresponding electrostatic potential and ionic distributions, and dielectric map. The server provides extra services to fix structural defects, as missing atoms in the structural file and allows for generation of missing hydrogen atoms. The hydrogen placement and the corresponding DelPhi calculations can be done with user selected force field parameters being either Charmm22, Amber98 or OPLS. Upon completion of the calculations, the user is given option to download fixed and protonated structural file, together with the parameter and Delphi output files for further analysis. Utilizing Jmol viewer, the user can see the corresponding structural file, to manipulate it and to change the presentation. In addition, if the potential map is requested to be calculated, the potential can be mapped onto the molecule surface. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver. PMID:24683424

Combined effects of VX-770 and VX-809 on several functional abnormalities of F508del-CFTR channels.

PubMed

Kopeikin, Z; Yuksek, Z; Yang, H-Y; Bompadre, S G

2014-09-01

The most common cystic fibrosis-associated mutation, the deletion of phenylalanine 508 (F508del), results in channels with poor membrane expression and impaired function. VX-770, a clinically approved drug for treatment of CF patients carrying the G551D mutation, and VX-809, a corrector shown in vitro to increase membrane expression of mutant channels, are currently undergoing clinical trials, but functional data at the molecular level is still lacking. The effect of VX-770 and VX-809 on the multiple functional defects of F508del-CFTR was assessed via excised inside-out patch-clamp experiments. VX-770 completely restores the low opening-rate of F508del-CFTR, with smaller open-time increase, in temperature-corrected and VX-809-treated channels. The shorter locked-open time of hydrolysis-deficient F508del-CFTR is also prolonged by VX-770. VX-809 does not improve channel function by itself as previously reported. The results from these studies can be interpreted as an equilibrium shift toward the open-channel conformation of F508del-CFTR channels. Copyright © 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

[Bibliometric analysis of Revista Médica del IMSS in the Scopus database for the period between 2005-2013].

PubMed

García-Gómez, Francisco; Ramírez-Méndez, Fernando

2015-01-01

To analyze the number of articles of Revista Médica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) in the Scopus database and describe principal quantitative bibliometric indicators of scientific publications during the period between 2005 to 2013. Scopus database was used limited to the period between 2005 to 2013. The analysis cover mainly title of articles with the title of Revista Médica del Instituto Mexicano del Seguro Social and its possible modifications. For the analysis, Scopus, Excel and Access were used. 864 articles were published during the period between 2005 to 2013 in the Scopus database. We identified authors with the highest number of contributions including articles with the highest citation rate and forms of documents cited. We also divided articles by subjects, types of documents and other bibliometric indicators which characterize the publications. The use of Scopus brings the possibility of analyze with an external tool the visibility of the scientific production published in the Revista Médica del IMSS. The use of this database also contributes to identify the state of science in México, as well as in the developing countries.

A new species of bark beetle, Dendroctonus mesoamericanus sp nov. (Curculionidae: Scolytinae), in southern Mexico and Central America

Treesearch

Francisco Armendariz-Toledano; Alicia Nino; Brian T. Sullivan; Lawrence R. Kirkendall; Gerado Zunig

2015-01-01

The bark beetle Dendroctonus mesoamericanus sp. nov. is described from a population in Parque Nacional Lagunas de Montebello, La Trinitaria, Chiapas, Mexico. This species belongs to the D. frontalis complex, which includes D. adjunctus Blandford 1897, D. approximatus Dietz 1890, D....

Reconversion Militar del Ejercito en la Frontera Dominico-Haitiana (Military Restructuring of the Army on the Dominican-Haitian Border)

DTIC Science & Technology

2013-05-22

Estado Mayor del Ejército de EE. UU. en cumplimiento parcial de los requisitos para la obtención del grado de MAESTRÍA EN CIENCIAS Y ARTES...MILITARES Estudios Generales Por MAYOR FELIPE CÉSPEDES TEJERA, EJÉRCITO NACIONAL DOMINICANO Licenciado en Ciencias Sociales, Universidad...ANSI Std. Z39.18 ii MAESTRÍA EN ARTES Y CIENCIAS MILITARES PÁGINA DE APROBACIÓN DE LA TESIS Nombre del Candidato: Mayor Felipe Céspedes Tejera

Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.

PubMed

Saussereau, Emilie Lyne; Roussel, Delphine; Diallo, Siradiou; Debarbieux, Laurent; Edelman, Aleksander; Sermet-Gaudelus, Isabelle

2013-01-01

Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR) defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF). Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (V(TE)) to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal V(TE) in CF mice must be well characterized for correct interpretation. We performed V(TE) measurements in large-scale studies of two mouse models of CF--B6;129 cftr knockout and FVB F508del-CFTR--and their respective wild-type (WT) littermates. We assessed the repeatability of the test for cftr knockout mice and defined cutoff points distinguishing between WT and F508del-CFTR mice. We determined the typical V(TE) values for CF and WT mice and demonstrated the existence of residual CFTR activity in F508del-CFTR mice. We characterized intra-animal variability in B6;129 mice and defined the cutoff points for F508del-CFTR chloride secretion rescue. Hyperpolarization of more than -2.15 mV after perfusion with a low-concentration Cl(-) solution was considered to indicate a normal response. These data will make it possible to interpret changes in nasal V(TE) in mouse models of CF, in future preclinical studies.

Forensic efficiency and genetic variation of 30 InDels in Vietnamese and Nigerian populations.

PubMed

Du, Weian; Peng, Zhiyong; Feng, Chunlei; Zhu, Bofeng; Wang, Bangchao; Wang, Yue; Liu, Chao; Chen, Ling

2017-10-24

Insertion/deletion polymorphisms (InDels) are ubiquitous diallelic genetic markers that have drawn increasing attention from forensic researchers. Here, we investigated 30 InDel loci in Vietnamese and Nigerian populations and evaluated their usefulness in forensic genetics. The polymorphic information content of these populations ranged, respectively, from 0.164 to 0.375 and from 0.090 to 0.375 across loci. After Bonferroni correction, no significant deviation from Hardy-Weinberg equilibrium was found, except for HLD97 in the Nigerian population. The cumulative power of exclusion for all 30 loci in the Vietnamese and Nigerian populations was 0.9870 and 0.9676, respectively, indicating that this InDel set is not suitable for paternity testing in these populations, but could be included as a supplement. For the Vietnamese and the Nigerian populations, the mean observed heterozygosity was 0.5917 and 0.6268, and the combined discrimination power of the 30 loci was 0.9999999999767 and 0.9999999999603, respectively. These findings indicated that these InDels may be suitable for personal forensic identification in the studied populations. The results of D A distance, phylogenetic tree, principal component, and cluster analyses were consistent and indicated a clear pattern of regional distribution. Moreover, the Vietnamese population was shown to have close genetic relationships with the Guangdong Han and Shanghai Han populations.

Forensic efficiency and genetic variation of 30 InDels in Vietnamese and Nigerian populations

PubMed Central

Du, Weian; Peng, Zhiyong; Feng, Chunlei; Zhu, Bofeng; Wang, Bangchao; Wang, Yue; Liu, Chao; Chen, Ling

2017-01-01

Insertion/deletion polymorphisms (InDels) are ubiquitous diallelic genetic markers that have drawn increasing attention from forensic researchers. Here, we investigated 30 InDel loci in Vietnamese and Nigerian populations and evaluated their usefulness in forensic genetics. The polymorphic information content of these populations ranged, respectively, from 0.164 to 0.375 and from 0.090 to 0.375 across loci. After Bonferroni correction, no significant deviation from Hardy-Weinberg equilibrium was found, except for HLD97 in the Nigerian population. The cumulative power of exclusion for all 30 loci in the Vietnamese and Nigerian populations was 0.9870 and 0.9676, respectively, indicating that this InDel set is not suitable for paternity testing in these populations, but could be included as a supplement. For the Vietnamese and the Nigerian populations, the mean observed heterozygosity was 0.5917 and 0.6268, and the combined discrimination power of the 30 loci was 0.9999999999767 and 0.9999999999603, respectively. These findings indicated that these InDels may be suitable for personal forensic identification in the studied populations. The results of DA distance, phylogenetic tree, principal component, and cluster analyses were consistent and indicated a clear pattern of regional distribution. Moreover, the Vietnamese population was shown to have close genetic relationships with the Guangdong Han and Shanghai Han populations. PMID:29179488

Extracorporeal membrane oxygenation in children with heart disease and del22q11 syndrome: a review of the Extracorporeal Life Support Organization Registry.

PubMed

Prodhan, P; Gossett, J M; Rycus, P T; Gupta, P

2015-11-01

The study objective was to evaluate outcomes among children with del22q11 (DiGeorge) syndrome supported on ECMO for heart disease. The ELSO registry database was queried to include all children <18 years undergoing heart surgery for either common atrio-ventricular canal, tetralogy of Fallot, truncus arteriosus or transposition of the great vessels and interrupted aortic arch and requiring ECMO, from 1998-2011. The outcomes evaluated included mortality, ECMO duration and length of hospital stay in patients with del22q11 syndrome and with no del22q11 syndrome. Eighty-eight ECMO runs occurred in children with del22q11 syndrome while 2694 ECMO runs occurred in children without del22q11 syndrome. For patients with heart defects receiving ECMO, del22q11 syndrome did not confer a significant mortality risk or an increased risk of infectious complications before or while on ECMO support. Neither the duration of ECMO nor mechanical ventilation prior to ECMO deployment were prolonged in patients with del22q11 syndrome compared to the controls. © The Author(s) 2015.

Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

PubMed

Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

2014-01-01

Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate.

Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

PubMed Central

Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M.; McClean, Phillip E.

2013-01-01

Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

78 FR 30268 - Del Norte County Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... Schools and Community Self-Determination Act (Pub. L. 112-141) (the Act) and operates in compliance with... to review prior year project's progress. Should the Secure Rural Schools Act be reauthorized, the.... ADDRESSES: The meetings will be held at the Del Norte County Unified School District, Redwood Room, 301 West...

Towards a GLOF hazard map for the city of Huaraz, Cordillera Blanca, Peru

NASA Astrophysics Data System (ADS)

Frey, Holger; Huggel, Christian; E Chisolm, Rachel; Gonzales, César; Cochachin, Alejo; Portocarrero, César

2017-04-01

Huaraz, with 120,000 inhabitants, is the largest city at the foot of the Cordillera Blanca Mountain Range, Peru, and is located at the confluence of the Quillcay River with the main Santa River. Three moraine dammed glacier lakes are located in the headwaters of the Quillcay catchment, which pose a potential threat of glacier lake outburst floods (GLOFs) to Huaraz: Laguna Cuchillacocha (2.5 x 106 m3), Laguna Tullparaju (12 x 106 m3), and Laguna Palcacocha (17 x 106 m3). The latter burst out in 1941, causing one of the deadliest GLOFs known in history, with about 2000 casualties and destroying a third of the city of Huaraz. Currently, the presence of these lakes within potential runout distances of possibly very large ice or rock/ice-avalanches, combined with the large damage potential in the city of Huaraz, some 20 km downstream of the lakes and further potentially endangered infrastructures such as the city of Trujillo, large-scale irrigation projects and hydropower plants along the Santa River poses a high-risk situation, despite lake safety systems at all three lakes were constructed in the last century. At Laguna Palcacocha, temporary measures, such as syphoning and a permanent supervision by a team of observers are undertaken at Laguna Palcacocha. For the future, more permanent measures are planned, including non-structural measures, such as a sensor-based early warning system for the entire catchment. In this framework, a preliminary GLOF hazard map for the entire Quillcay catchment has been developed, based on physically-based numerical modeling. For each of the three lakes, three scenarios of different magnitudes and related probabilities were modeled. For each case, a series of models was used to simulate each part of the chain of interacting processes. The eventual GLOFs were simulated with FLO2D for Palcacocha and RAMMS for Tullparaju and Cuchillacocha. Small, medium and large scenarios were merged for all three lakes, in order to come up with a single

Reducing risks from hazardous glacier lakes in the Cordillera Blanca (Peru): Six decades of experience and perspectives for the future

NASA Astrophysics Data System (ADS)

Portocarrero, Cesar; Cochachin, Alejo; Frey, Holger; González, Cesar; Haeberli, Wilfried; Huggel, Christian

2016-04-01

Outbursts from glacier lakes at various spatial and temporal scales have had marked geomorphological effects in many mountain ranges. In many glacierized Andean mountain regions substrates of human settlements made out of flood and debris-flow deposits are testimonies of such events. Examples in the Cordillera Blanca, Peru, are the towns of Caraz, Carhuaz or parts of Huaraz. Continued glacier shrinking since the end of the Little Ice Age caused the formation or enlargement of numerous lakes. The outburst of Laguna Palcacocha, destroying the centre of Huaraz and causing more than 1800 losses of life in December 1941, marked the beginning of systematic risk reduction work in Peru. Corresponding efforts included glacier and lake inventories, hazard assessments, definition of high-risk situations, and completion of engineering work for lake-level lowering in more than 30 cases. The latter comprises outlet reinforcements on morainic dams as well as artificial tunnels in bedrock thresholds. This work has been remarkably efficient as documented in the latest case of the Laguna Huallcacocha (Carhuaz-Ancash), where the earlier made installations withstood the erosive power of an impact wave from an ice avalanche in 2015. In the case of the Laguna 513, the impact wave and far-reaching flood caused by a rock/ice avalanche from Nevado Hualcán in April 2010 showed that the risk had been essentially reduced by the preventive lake-level lowering in the early 1990s but not to zero. Risk assessments, planning, construction and non-structural risk reduction efforts continue. Work is in progress to increase the safety of Laguna Palcacocha where extensive assessments and model calculations had been carried out. Risks related to rock/ice avalanches into lakes from steep icy slopes and related to de-buttressing processes as well as long-term permafrost degradation increases. Based on morphological indications and numerical modelling (GlabTop) an inventory of possible future lakes

Casimir force in the Gödel space-time and its possible induced cosmological inhomogeneity

NASA Astrophysics Data System (ADS)

Khodabakhshi, Sh.; Shojai, A.

2017-07-01

The Casimir force between two parallel plates in the Gödel universe is computed for a scalar field at finite temperature. It is observed that when the plates' separation is comparable with the scale given by the rotation of the space-time, the force becomes repulsive and then approaches zero. Since it has been shown previously that the universe may experience a Gödel phase for a small period of time, the induced inhomogeneities from the Casimir force are also studied.

Combination of t(4;14), del(17p13), del(1p32) and 1q21 gain FISH probes identifies clonal heterogeneity and enhances the detection of adverse cytogenetic profiles in 233 newly diagnosed multiple myeloma.

PubMed

Smol, Thomas; Dufour, Annika; Tricot, Sabine; Wemeau, Mathieu; Stalnikiewicz, Laure; Bernardi, Franck; Terré, Christine; Ducourneau, Benoît; Bisiau, Hervé; Daudignon, Agnès

2017-01-01

Our aim was to set the FISH combination of del(17p13), t(4;14), 1q21 gain and del(1p32), four adverse cytogenetic factors rarely evaluated together, and compare our technical thresholds with those defined in the literature. Two hundred thirty-three patients with MM at diagnosis were studied using FISH to target 4 unfavorable cytogenetic abnormalities: 17p13 deletion, t(4;14) translocation, 1p32 deletion and 1q21 gain. Technical thresholds were determined for each probe using isolated CD138-expressing PC from patients without MM. The FISH analysis identified abnormalities in 79.0% of patients. Del(17p13) was detected in 15.0% of cases, t(4;14) in 11.5%, 1q21 gain in 37.8% and del(1p32) in 8.7%. Adding 1p32/1q21 FISH probes has enabled us to identify adverse cytogenetic profiles in 39.0% of patients without del(17p13) or t(4;14). Clonal heterogeneity was observed in 51.1% of patients as well as an increase in the number of adverse abnormalities when related clones were greater than or equal to 2 (85.1% against 45.6%). FISH allowed detecting accumulation of adverse abnormalities and clonal heterogeneity in MM with a combination of 4 probes. The impacts of these two parameters need to be evaluated, and could be included in future cytogenetic classifications.

El diseño final del espectrógrafo de banco (EBASIM) para CASLEO

NASA Astrophysics Data System (ADS)

Simmons, J.; Levato, H.

Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

[Effectiveness of azacitidine in chronic myelomonocytic leukemia harboring del(20q) - a case report].

PubMed

Manabe, Masahiro; Okita, Junya; Takakuwa, Teruhito; Harada, Naonori; Aoyama, Yasutaka; Kumura, Takeo; Ohta, Tadanobu; Furukawa, Yoshio; Mugitani, Atsuko

2014-06-01

A 7 1-year-old man was admitted to our hospital with leukocytosis and anemia. Chronic myelomonocytic leukemia (CMML)harboring del(20q)was diagnosed by peripheral blood examination and bone marrow aspiration. The patient was subsequently treated with azacitidine, which resulted in rapid disappearance of monocytosis and resolved his dependency on red cell transfusion. With regard to the chromosomal abnormality, although del(20q)is estimated to be encountered in approximately 0.7-1.0% of all CMML cases, its significance in prognosis has not been fully analyzed. Hence, more such cases need to be evaluated to elucidate the therapeutic outcome of CMML involving del(20q). In addition, the Wilms tumor-1(WT 1)level in the patient gradually decreased after the initiation of azacitidine therapy. This phenomenon of WT1 decrease synchronizing with the patient's clinical improvement might reflect therapeutic efficacy with regard to the clinical course, as had been observed in acute myeloid leukemia and myelodysplastic syndrome.

DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT

EPA Science Inventory

EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

ERIC Educational Resources Information Center

Karadima, Oscar

An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

Lack of effect of the alpha2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells.

PubMed

Montgomery, M D; Bylund, D B

2010-02-01

The alpha(2C)-adrenoceptor has multiple functions, including inhibiting release of noradrenaline from presynaptic nerve terminals. A human alpha(2C) polymorphism, Del322-325, a potential risk factor for heart failure, has been reported to exhibit reduced signalling in CHO cells. To further understand the role of the Del322-325 polymorphism on receptor signalling, we attempted to replicate and further study the reduced signalling in HEK293 cells. Human alpha(2C) wild-type (WT) and Del322-325 adrenoceptors were stably transfected into HEK293 cells. Radioligand binding was performed to determine affinities for both receptors. In intact cells, inhibition of forskolin-stimulated cyclic AMP production by WT and Del322-325 clones with a range of receptor densities (200-2320 fmol.mg(-1) protein) was measured following agonist treatment. Noradrenaline, brimonidine and clonidine exhibited similar binding affinities for WT and Del322-325. Brimonidine and clonidine also had similar efficacies and potencies for both receptors for the inhibition of cyclic AMP production at all receptor densities tested. A linear regression analysis comparing efficacy and potency with receptor expression levels showed no differences in slopes between WT and Del322-325. The alpha(2C) WT and Del322-325 adrenoceptors exhibited similar binding properties. Additionally, inhibition of cyclic AMP production by Del322-325 was similar to that of WT over a range of receptor densities. Therefore, in intact HEK293 cells, the alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype.

[Trattamento farmacologico del disturbo da uso di alcol. Evidenze scientifiche].

PubMed

Attilia, Fabio; Perciballi, Roberta; Rotondo, Claudia; Capriglione, Ida; Iannuzzi, Silvia; Attilia, Maria Luisa; Vitali, Mario; Alessandrini, Giovanni; Scamporrino, Maria Concetta Marcella; Fiore, Marco; Ceccanti, Mauro

2018-01-01

RIASSUNTO. La terapia farmacologica nei pazienti con disturbo da uso di alcol riveste un ruolo centrale nel progetto terapeutico, altamente contestualizzato in un approccio multidisciplinare. Sebbene i trattamenti non farmacologici per la dipendenza da alcol risultino ben strutturati e in continua evoluzione, dal punto di vista medico le possibilità di intervento sono realmente ristrette, con poche molecole a disposizione approvate per il disturbo da uso di alcol: nello specifico, l'acamprostato, il naltrexone e, più recentemente, il nalmefene tra gli anticraving; il disulfiram tra gli avversivanti. Nuovi approcci sperimentali stanno cercando di ampliare tale gamma attraverso l'utilizzo di farmaci off-label. Evidenze scientifiche devono supportare l'indicazione terapeutica, quest'ultima deve dimostrarsi "cucita" sulle esigenze del paziente e sulle comorbilità presenti tenendo conto del profilo bio-psico-sociale individuale. Fondamentale risulta il follow-up per valutare la ritenzione in trattamento e il monitoraggio degli outcome alcologici.

Pío del Río Hortega and the discovery of the oligodendrocytes

PubMed Central

Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

2015-01-01

Pío del Río Hortega (1882–1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal’s laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

CHEK2*1100delC Variant and BRCA1/2-Negative Familial Breast Cancer - A Family-Based Genetic Association Study

DTIC Science & Technology

2007-10-01

AD_________________ Award Number: DAMD17-03-1-0774 TITLE: CHEK2 *1100delC Variant and BRCA1/2...NUMBER CHEK2 *1100delC Variant and BRCA1/2-Negative Familial Breast Cancer - A Family- Based Genetic Association Study 5b. GRANT NUMBER DAMD17...association between the CHEK2 *1100delC gene variant and breast cancer among BRCA1/2-negative families. Vital to DNA replication and normal growth of breast

The Cuernos del Paine mountains in Torres del Paine National Park in Chile provide a backdrop to a herd of guanacos during NASA's AirSAR 2004 campaign

NASA Image and Video Library

2004-03-11

The Cuernos del Paine mountains in Torres del Paine National Park in Chile provide a backdrop to a herd of guanacos during NASA's AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition in Central and South America by an international team of scientists that is using an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), located onboard NASA's DC-8 airborne laboratory. Scientists from many parts of the world are combining ground research with NASA's AirSAR technology to improve and expand on the quality of research they are able to conduct. Founded in 1959, Torres del Paine National Park encompasses 450,000 acres in the Patagonia region of Chile. This region is being studied by NASA using a DC-8 equipped with an Airborne Synthetic Aperture Radar (AirSAR) developed by scientists from NASA’s Jet Propulsion Laboratory. This is a very sensitive region that is important to scientists because the temperature has been consistently rising causing a subsequent melting of the region’s glaciers. AirSAR will provide a baseline model and unprecedented mapping of the region. This data will make it possible to determine whether the warming trend is slowing, continuing or accelerating. AirSAR will also provide reliable information on ice shelf thickness to measure the contribution of the glaciers to sea level.

76 FR 23649 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition and Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... field research), the potential global population of free-ranging Morelet's crocodiles in 2004 was... will include monitoring and harvest of Morelet's crocodiles and hybrids for scientific research (CITES... Biosphere Reserve, Laguna de T[eacute]rminos Biosphere Reserve, Hampolol Wildlife Conservation and Research...

WATER COLUMN DATA AND SPECTRAL IRRADIANCE MODEL

EPA Science Inventory

Water samples collected monthly, for 18 months, from six sites in the Laguna Madre were analyzed to identify and quantify phytopigments using High Performance Liquid Chromatography (HPLC). In addition, water column pigment and nutrient data were acquired at 12 stations in Upper ...

Ground Wave Emergency Network. Final Operational Capability. Environmental Assessment for Southern Nevada Relay Node, Site No. RN 8W918NV

DTIC Science & Technology

1993-03-05

Supervisor, Fish and Wildlife Service, Ventura, California Field Supervisor, Fish and Wildlife Service, Laguna Nigel, California Assistant Regional...the weight regressions developed by Dr. Michael Weinstein for the tortoises at the Honda project. If a tortoise is determined to be underweight, the

STABLE CARBON ISOTOPE EVIDENCE FOR COUPLING BETWEEN SEDIMENTARY BACTERIA AND SEAGRASSES IN A SUB-TROPICAL LAGOON

EPA Science Inventory

We measured stable carbon isotope ratios (d13C) in phospholipid fatty acids (PLFAs) to identify the primary carbon source utilized by sedimentary bacteria in Lower Laguna Madre, Texas, which is a seagrass dominated lagoon. Comparisons were made between three differing habitat ty...

Baja Earthquake Perspective View

NASA Image and Video Library

2010-04-05

The topography surrounding the Laguna Salada Fault in the Mexican state of Baja, California, is shown in this combined radar image and topographic view with data from NASA Shuttle Radar Topography Mission where a 7.2 earthquake struck on April 4, 2010.

Generalized Gödel universes in higher dimensions and pure Lovelock gravity

NASA Astrophysics Data System (ADS)

Dadhich, Naresh; Molina, Alfred; Pons, Josep M.

2017-10-01

The Gödel universe is a homogeneous rotating dust with negative Λ which is a direct product of a three-dimensional pure rotation metric with a line. We would generalize it to higher dimensions for Einstein and pure Lovelock gravity with only one N th-order term. For higher-dimensional generalization, we have to include more rotations in the metric, and hence we shall begin with the corresponding pure rotation odd (d =2 n +1 )-dimensional metric involving n rotations, which eventually can be extended by a direct product with a line or a space of constant curvature for yielding a higher-dimensional Gödel universe. The considerations of n rotations and also of constant curvature spaces is a new line of generalization and is being considered for the first time.

Comparative oceanography of coastal lagoons

NASA Technical Reports Server (NTRS)

Kjerfve, Bjorn

1986-01-01

The hypothesis that physical lagoon characteristics and variability depend on the channel connecting the lagoon to the adjacent coastal ocean is evaluated. The geographical, hydrological, and oceanographic characteristics of 10 lagoon systems are described and analyzed; these oceanographic features are utilized to classify the lagoon systems. Choked lagoons (Laguna Joyuda, Coorong, Lake St.Lucia, Gippsland Lakes, Lake Songkla/Thale Luang/Thale Noi, and Lagoa dos Patos) are prevalent on coasts with high wave energy and low tidal range; restricted lagoons (Lake Pontchartrain and Laguna de Terminos) are located on low/medium wave energy coasts with a low tidal range; and leaky lagoons (Mississippi Sound and Belize Lagoon/Chetumal Bay) are connected to the ocean by wide tidal passes that transmit oceanic effects into the lagoon with a minimum of resistance. The data support the hypothesis that the nature of the connecting channel controls system functions.

The effect of the common c.2299delG mutation in USH2A on RNA splicing.

PubMed

Lenassi, Eva; Saihan, Zubin; Bitner-Glindzicz, Maria; Webster, Andrew R

2014-05-01

Recessive variants in the USH2A gene are an important cause of both Usher syndrome and nonsyndromic retinitis pigmentosa. A single base-pair deletion in exon 13 (c.2299delG, p.Glu767Serfs*21) is considered the most frequent mutation of USH2A. It is predicted to generate a premature termination codon and is presumed to lead to nonsense mediated decay. However the effect of this variant on RNA has not been formally investigated. It is not uncommon for exonic sequence alterations to cause aberrant splicing and the aim of the present report is to evaluate the effect of c.2299delG on USH2A transcripts. Nasal cells represent the simplest available tissue to study splicing defects in USH2A. Nasal brushing, RNA extraction from nasal epithelial cells and reverse transcription PCR were performed in five Usher syndrome patients who were homozygous for c.2299delG, two unaffected c.2299delG heterozygotes and seven control individuals. Primers to amplify between exons 12 and 15 and exons 10 and 14 were utilised. Significant variability was observed between different RT-PCR experiments. Importantly, in controls, PCR product of the expected size were amplified on all occasions (13/13 experiments); for patients this was true in only 4/14 experiments (Fisher exact test p = 0.0002). Bioinformatics tools predict the c.2299delG change to disrupt an exonic splicing enhancer and to create an exonic splicing silencer within exon 13. Here, we report an effect of the common c.2299delG mutation on splicing of exons 12 and 13 of USH2A. Future studies are expected to provide important insights into the contribution of this effect on the phenotype. Copyright © 2014 Elsevier Ltd. All rights reserved.

Cosmogenic Radionuclides in the Campo Del Cielo Iron Meteorite

NASA Technical Reports Server (NTRS)

Liberman, R. G.; FernandezNiello, J. O.; Reedy, R. C.; Fifield, L. K.; diTada, M. L.

2001-01-01

Cosmogenic Be-10, Al-26, Cl-36, Ca-41, and Ni-59 were measured in the Campo del Cielo iron meteorite. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented. Additional information is contained in the original extended abstract.

Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico

NASA Astrophysics Data System (ADS)

Cintron Aponte, Rommel

La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

Prevalence of 2314delG mutation in Spanish patients with Usher syndrome type II (USH2).

PubMed

Beneyto, M M; Cuevas, J M; Millán, J M; Espinós, C; Mateu, E; González-Cabo, P; Baiget, M; Doménech, M; Bernal, S; Ayuso, C; García-Sandoval, B; Trujillo, M J; Borrego, S; Antiñolo, G; Carballo, M; Nájera, C

2000-06-01

The Usher syndrome (USH) is a group of autosomal recessive diseases characterized by congenital sensorineural hearing loss and retinitis pigmentosa. Three clinically distinct forms of Usher syndrome have so far been recognized and can be distinguished from one another by assessing auditory and vestibular function. Usher syndrome type II (USH2) patients have congenital moderate-to-severe nonprogressive hearing loss, retinitis pigmentosa, and normal vestibular function. Genetic linkage studies have revealed genetic heterogeneity among the three types of USH, with the majority of USH2 families showing linkage to the USH2A locus in 1q41. The USH2A gene (MIM 276901) has been identified: three mutations, 2314delG, 2913delG, and 4353-54delC, were initially reported in USH2A patients, the most frequent of which is the 2314delG mutation. It has been reported that this mutation can give rise to typical and atypical USH2 phenotypes. USH2 cases represent 62% of all USH cases in the Spanish population, and 95% of these cases have provided evidence of linkage to the USH2A locus. In the present study, the three reported mutations were analyzed in 59 Spanish families with a diagnosis of USH type II. The 2314delG was the only mutation identified in our population: it was detected in 25% of families and 16% of USH2 chromosomes analyzed. This study attempts to estimate the prevalence of this common mutation in a homogeneous Spanish population.

An experiment of formation of charmoni states in annihilation P-Pbarra. Un esperimento di formazione di stati del charmonio in annichilazione P-Pbarra (in Italian)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pallavicini, Marco

1995-01-01

Oggetto di questa tesi e la misura di alcune caratteristiche fisiche (massa, larghezza, e larghezza parziale in p -more » $$\\bar{p}$$) degli stati 3P 1 e 3P 2 del charmonio, -ovvero del sistema legato di un quark "charm" e del suo antiquark-, nell'amito dell'esperimento E-760, installato nell'accumulatore di antiprotoni del Fermilab.« less

Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

NASA Astrophysics Data System (ADS)

Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

First Results of the Expedition to the Highest Lake on Earth: Studying a Martian Paleolake in Bolivia and the Survival Strategies Developed by Living Organisms

NASA Technical Reports Server (NTRS)

Cabrol, N. A.; Grin, E. A.; McKay, C. P.; Friedmann, I.; Diaz, D. Chong; Demergasso, C.; Kisse, K.; Grigorszky, I.; Friedmann, R. Ocampo; Murbach, M. S.

2003-01-01

Between October 16th and November 9th 2002, the first NASA Ames DDF Licancabur multidisciplinary expedition initiated the investigation of the biology and environment for life in the highest lake on Earth located at the summit of the Licancabur volcano (6017 m/20,056 ft) at the boundary of Chile and Bolivia. The low oxygen, low atmospheric pressure, high-UV radiation, average temperature, volcano-tectonic and hydrothermal environment make the site a close analog to Martian paleolakes 3.5 billion years ago. The overall goal of the project is to understand through a series of high altitude scientific expeditions what strategies life is using to defend itself against killer-level UV radiation and environmental extreme conditions at this altitude. Several other lakes are located at 4300 m at the foot of the Licancabur volcano (hereafter named laguna Blanca and Laguna Verde). They were also investigated using identical experiments and methods as for the summit lake in order to compare the results and better understand the evolution of survival strategies at transitioning elevations. The lagunas are geothermally heated and many springs provide water at various temperatures. Sources of heat are also suspected for the summit lake as its surface water temperature was measured during the successful ascent at +6 C in a -9 C ambient crater environment (with a wind chill factor of -25 C with a wind blowing almost constantly). Results of this project are expected to provide critical keys to help searching and identifying potential sites for life (extant/extinct) on Mars and developing instruments, experiments and technologies for future missions.

Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

ERIC Educational Resources Information Center

Ford-Guerrera, Rebecca

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math…

Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women.

PubMed

Rah, HyungChul; Jeon, Young Joo; Choi, Youngsok; Shim, Sung Han; Yoon, Tae Ki; Choi, Dong Hee; Cha, Sun Hee; Kim, Nam Keun

2012-11-01

The aim of our study was to investigate whether methylenetetrahydrofolate reductase (MTHFR) gene variant (MTHFR 677C>T) and thymidylate synthase (TS) gene variants (TS enhancer region [TSER] and TS 1494del6) confer a risk for premature ovarian failure (POF). We genotyped 136 POF patients and 236 controls among Korean women for the three single nucleotide polymorphism sites using polymerase chain reaction restriction fragment length polymorphism analysis. Differences in the MTHFR 677C>T, TSER, and TS 1494del6 genotype frequencies between POF patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as a measure of the strength of the association between genotypes and POF. The MTHFR 677CT and CT + TT variant genotypes were more frequent in POF patients than in controls (OR, 2.249; 95% CI, 1.317-3.843; and OR, 2.132; 95% CI, 1.268-3.585, respectively). The combined genotype frequencies of MTHFR 677CT + TT/TSER 3R3R and 677CT + TT/TS 1494del6 del6/del6 were higher in patients than in controls (OR, 2.300; 95% CI, 1.219-4.337; and OR, 3.314; 95% CI, 1.623-6.767, respectively). The T-3R-del6 and T-2R-del6 (MTHFR 677C>T/TSER/TS 1494del6) haplotypes were more frequent in patients (OR, 1.450; 95% CI, 1.050-2.002; and OR, 2.911; 95% CI, 1.191-7.117, respectively), whereas the C-2R-del6 haplotype was less frequent in patients (OR, 0.372; 95% CI, 0.152-0.912). The T-del6 (MTHFR 677/TS 1494del6) haplotype frequency was higher among patients (OR, 1.653; 95% CI, 1.206-2.266), whereas the C-del6 haplotype frequency was lower among patients (OR, 0.700; 95% CI, 0.516-0.950). We did not find an association between TSER or TS 1494del6 polymorphisms and POF. Our data suggest that the MTHFR 677T allele may increase the risk for POF, which could lead to the development of novel genetic markers for predicting the risk of POF in patients.

Prevalencia y tamizaje del Trastorno por Déficit de Atención con Hiperactividad en Costa Rica

PubMed Central

Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.

2015-01-01

Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno por Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado por el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados por los padres fue más baja que aquella de los maestros. El SNAP-IV completado por las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094

Systematically frameshifting by deletion of every 4th or 4th and 5th nucleotides during mitochondrial transcription: RNA self-hybridization regulates delRNA expression.

PubMed

Seligmann, Hervé

2016-01-01

In mitochondria, secondary structures punctuate post-transcriptional RNA processing. Recently described transcripts match the human mitogenome after systematic deletions of every 4th, respectively every 4th and 5th nucleotides, called delRNAs. Here I explore predicted stem-loop hairpin formation by delRNAs, and their associations with delRNA transcription and detected peptides matching their translation. Despite missing 25, respectively 40% of the nucleotides in the original sequence, del-transformed sequences form significantly more secondary structures than corresponding randomly shuffled sequences, indicating biological function, independently of, and in combination with, previously detected delRNA and thereof translated peptides. Self-hybridization decreases delRNA abundances, indicating downregulation. Systematic deletions of the human mitogenome reveal new, unsuspected coding and structural informations. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

New Mexico Pueblos Confront the Atomic Age.

ERIC Educational Resources Information Center

Barry, Tom

1979-01-01

While mineral development in Indian Country offers economic benefits, it can also pollute the air and water and destroy the land itself. Article describes three different approaches that Laguna, Acoma and Santo Domingo Pueblos are using to deal with exploitation of their natural resources. (DS)

Foreword

NASA Astrophysics Data System (ADS)

Benisty, Henri; Kawakami, Shojiro; Norris, David J.; Soukoulis, Costas M.

2004-10-01

The Fifth International Symposium on Photonic and Electromagnetic Crystal Structures (PECS-V) was held in Kyoto, Japan (2004). The Symposium followed the format of previous international meetings held at Laguna Beach, USA (1999), Sendai, Japan (2000), St. Andrews, UK (2001) and Los Angeles, USA (2002).

78 FR 64248 - Notice Pursuant to The National Cooperative Research and Production Act of 1993; DVD Copy Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

..., Shenzhen, PEOPLE'S REPUBLIC OF CHINA; Smart Electronics Manufacturing Service Philippine, Calamba City, Laguna, PHILIPPINES; SoJean International Co., Ltd., His-Chih City, Taipei Hsien, TAIWAN; and YuCha (Hong...; CyberLink Corporation, Shindian City, Taipei, TAIWAN; D&M Holdings Inc., Chuo-ku, Tokyo, JAPAN; Daesung...

SEAGRASS STRESS RESPONSE MODEL: THE IMPORTANCE OF LIGHT, TEMPERATURE, SEDIMENTATION AND GEOCHEMISTRY

EPA Science Inventory

Our objective is to define interactions between seagrass and water-column and sediment stressors. The model was developed and optimized for sediments in Thalassia testudinum seagrass beds of Lower Laguna Madre, Texas, USA and is composed of a plant sub-model and a sediment diagen...

Null geodesics and wave front singularities in the Gödel space-time

NASA Astrophysics Data System (ADS)

Kling, Thomas P.; Roebuck, Kevin; Grotzke, Eric

2018-01-01

We explore wave fronts of null geodesics in the Gödel metric emitted from point sources both at, and away from, the origin. For constant time wave fronts emitted by sources away from the origin, we find cusp ridges as well as blue sky metamorphoses where spatially disconnected portions of the wave front appear, connect to the main wave front, and then later break free and vanish. These blue sky metamorphoses in the constant time wave fronts highlight the non-causal features of the Gödel metric. We introduce a concept of physical distance along the null geodesics, and show that for wave fronts of constant physical distance, the reorganization of the points making up the wave front leads to the removal of cusp ridges.

Functional characterization of a basic helix-loop-helix (bHLH) transcription factor GhDEL65 from cotton (Gossypium hirsutum).

PubMed

Shangguan, Xiao-Xia; Yang, Chang-Qing; Zhang, Xiu-Fang; Wang, Ling-Jian

2016-10-01

Cotton fiber is proposed to share some similarity with the Arabidopsis thaliana leaf trichome, which is regulated by the MYB-bHLH-WD40 transcription complex. Although several MYB transcription factors and WD40 family proteins in cotton have been characterized, little is known about the role of bHLH family proteins in cotton. Here, we report that GhDEL65, a bHLH protein from cotton (Gossypium hirsutum), is a functional homologue of Arabidopsis GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) in regulating trichome development. Transcripts of GhDEL65 were detected in 0 ∼ 1 days post-anthesis (DPA) ovules and abundant in 3-DPA fibers, implying that GhDEL65 may act in early fiber development. Ectopic expression of GhDEL65 in Arabidopsis gl3 egl3 double mutant partly rescued the trichome development, and constitutive expression of GhDEL65 in wild-type plants led to increased trichome density on rosette leaves and stems, mainly by activating the transcription of two key positive regulators of trichome development, GLABRA1 (GL1) and GLABRA2 (GL2), and suppressed the expression of a R3 single-repeat MYB factor TRIPTYCHON (TRY). GhDEL65 could interact with cotton R2R3 MYB transcription factors GhMYB2 and GhMYB3, as well as the WD40 protein GhTTG3, suggesting that the MYB-bHLH-WD40 protein complex also exists in cotton fiber cell, though its function in cotton fiber development awaits further investigation. © 2016 Scandinavian Plant Physiology Society.

CONTAMINACIÓN AMBIENTAL, VARIABILIDAD CLIMÁTICA Y CAMBIO CLIMÁTICO: UNA REVISIÓN DEL IMPACTO EN LA SALUD DE LA POBLACIÓN PERUANA

PubMed Central

Gonzales, Gustavo F.; Zevallos, Alisson; Gonzales-Castañeda, Cynthia; Nuñez, Denisse; Gastañaga, Carmen; Cabezas, César; Naeher, Luke; Levy, Karen; Steenland, Kyle

2015-01-01

RESUMEN El presente artículo es una revisión sobre la contaminación del agua, el aire y el efecto del cambio climático en la salud de la población peruana. Uno de los principales contaminantes del aire es el material particulado menor de 2,5 μ (PM 2,5), en la ciudad de Lima, anualmente 2300 muertes prematuras son atribuibles a este contaminante. Otro problema es la contaminación del aire domiciliario por el uso de cocinas con combustible de biomasa, donde la exposición excesiva a PM 2,5 dentro de las casas es responsable de aproximadamente 3000 muertes prematuras anuales entre adultos, con otro número desconocido de muertes entre niños debido a infecciones respiratorias. La contaminación del agua tiene como principales causas los desagües vertidos directamente a los ríos, minerales (arsénico) de varias fuentes, y fallas de las plantas de tratamiento. En el Perú, el cambio climático puede impactar en la frecuencia y severidad del fenómeno de El Niño oscilación del sur (ENSO) que se ha asociado con un incremento en los casos de enfermedades como cólera, malaria y dengue. El cambio climático incrementa la temperatura y puede extender las áreas afectadas por enfermedades transmitidas por vectores, además de tener efecto en la disponibilidad del agua y en la contaminación del aire. En conclusión, el Perú, pasa por una transición de factores de riesgo ambientales, donde coexisten riesgos tradicionales y modernos, y persisten los problemas infecciosos y crónicos, algunos de los cuales se asocian con problemas de contaminación de agua y de aire. PMID:25418656

Impacto del Seguro Popular en el gasto catastrófico y de bolsillo en el México rural y urbano, 2005–2008

PubMed Central

Sosa-Rubí, Sandra G; Salinas-Rodríguez, Aarón; Galárraga, Omar

2016-01-01

Objetivo Estimar el efecto del Seguro Popular (SP) sobre la incidencia del gasto catastrófico en salud (GCS) y sobre el gasto de bolsillo en salud (GBS) en el mediano plazo. Material y métodos Con base en la Encuesta de Evaluación del Seguro Popular (2005–2008), se analizaron los resultados del efecto del SP en la cohorte rural para dos años de seguimiento (2006 y 2008) y en la cohorte urbana para un año (2008). Resultados A nivel conglomerado no se detectaron efectos del SP. A nivel hogar se encontró que el SP tiene un efecto protector en el GCS y en el GBS en consulta externa y hospitalización en zonas rurales; y efectos significativos en la reducción de GBS en consulta externa en zonas urbanas. Conclusiones El SP se muestra como un programa efectivo para proteger a los hogares contra gastos de bolsillo por motivos de salud en el mediano plazo. PMID:22282205

Wave maps from Gödel's universe

NASA Astrophysics Data System (ADS)

Barletta, Elisabetta; Dragomir, Sorin; Magliaro, Marco

2014-10-01

Using a result by Koch (1988 Trans. Am. Math. Soc. 307 827-41) we realize Gödel's universe G_{α }^{4}=({{{R}}^{4}},{{g}_{α}}) as the total space of a principal {R}-bundle over a strictly pseudo-convex CR manifold M3 and exploit the analogy between {{g}_{Yalpha;}} and Fefferman's metric {{F}_{θ}} (Fefferman 1976 Ann. Math. 103 395-416 104 393-4) to show that for any {R}-invariant wave map Φ of G_{α}^{4} into a Riemannian manifold N, the corresponding base map φ :{{M}^{3}}\\to N is subelliptic harmonic, with respect to a canonical choice of contact form θ on M3. We show that the subelliptic Jacobi operator J_{b}^{φ} of ϕ has a discrete Dirichlet spectrum on any bounded domain D\\subset {{M}^{3}} supporting the Poincaré inequality on \\mathop{W}\\limits^{\\circ }{}_{H}^{1,2}(D,{{φ}^{-1}}TN) and Kondrakov compactness, i.e. compactness of the embedding \\mathop{W}\\limits^{\\circ }{}_{H}^{1,2}(D,{{φ }^{-1}}TN)\\hookrightarrow {{L}^{2}}(D,{{φ}^{-1}}TN). We exhibit an explicit solution π :G_{α}^{4}\\to {{M}^{3}} to the wave map system on G_{α}^{4}, of index in{{d}^{Ω}}(π)\\geqslant 1 for any bounded domain Ω \\subset G_{α}^{4}. Mounoud's distance (Mounoud 2001 Differ. Geom. Appl. 15 47-57) d_{{{G}_{0}}, Ω }^{∞}({{g}_{α }}, {{F}_{θ}}) is bounded below by a constant depending only on the rotation frequency of Gödel's universe, thus giving a measure of the bias of {{g}_{α}} from being Fefferman like in the region Ω \\subset {{{R}}^{4}}.

Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)

USGS Publications Warehouse

Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio O.

1998-01-01

A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiersma, G.B.; Kohler, A.; Boelcke, C.

1985-10-01

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. Wemore » also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.« less

A Holocene Lake Record from Laguna Del Maule (LdM) in the Chilean Andes: Climatic and Volcanic Controls on Lake Depositional Dynamics

NASA Astrophysics Data System (ADS)

Valero-Garces, B. L.; Frugone Alvarez, M.; Barreiro-Lostres, F.; Carrevedo, M. L.; Latorre Hidalgo, C.; Giralt, S.; Maldonado, A.; Bernárdez, P.; Prego, R.; Moreno-Caballud, A.

2014-12-01

Central Chile is a tectonically active, drought-prone region sensitive to latitudinal variations in large-scale cold fronts associated with fluctuations of the Pacific subtropical high. Holocene high-resolution records of climate and volcanic events could help inform more on the frequency of extensive droughts as well as volcanic and seismic hazards. LdM is a high altitude, volcanic lake located in the Transition Southern Volcanic Zone (~36°S, 2200 m.a.s.l). The LdM volcanic field is a very seismically and volcanically active zone in the Andes, with several caldera-forming eruptions over the last 1.5 Ma, and intense postglacial activity. In 2013, we recovered over 40 m of sediment cores at four sites of LdM and collected > 20 km of seismic lines. The cores were imaged, their physical and geochemical properties analysed with a Geotek MSCL and XRF scanner respectively, and sampled for TOC, TIC, TS, TN, BioSi, and bulk mineralogy. The chronology was constructed with a Bayesian age-depth model including 210Pb-137Cs, the Quizapú volcanic ash (1932 AD) and 17 AMS 14C dates. The 4.8 m long composite sequence spans the Late glacial and Holocene.Sediments are massive to banded, quartz and plagioclase-rich silts with variable diatom (BioSi, 15- 30 %) and organic matter content (TOC, 1-5 %). Four main units have been defined based on sedimentological and geochemical composition. The transition from Unit 4 to 3 is ascribed to the onset of the Holocene; Unit 2 spans the mid Holocene, and Unit 1 the last 4 ka. Higher (lower) TOC, Br/Ti and Fe/Mn ratios in units 1 and 3 (2 and 4) suggest higher (lower) organic productivity in the lake and dominant oxic (anoxic) conditions at the bottom of the lake. Up to 17 ash and lapilli layers mark volcanic events, mostly grouped in units 1 and 3. Periods of higher lake productivity (units 1 and 3) are synchronous to higher frequency of volcanic events. Some climate transitions (LIA, 4ka, 8ka and 11ka) are evident in the LdM sequence underlining their paleohydrological regional significance.

Development and validation of an automated delirium risk assessment system (Auto-DelRAS) implemented in the electronic health record system.

PubMed

Moon, Kyoung-Ja; Jin, Yinji; Jin, Taixian; Lee, Sun-Mi

2018-01-01

A key component of the delirium management is prevention and early detection. To develop an automated delirium risk assessment system (Auto-DelRAS) that automatically alerts health care providers of an intensive care unit (ICU) patient's delirium risk based only on data collected in an electronic health record (EHR) system, and to evaluate the clinical validity of this system. Cohort and system development designs were used. Medical and surgical ICUs in two university hospitals in Seoul, Korea. A total of 3284 patients for the development of Auto-DelRAS, 325 for external validation, 694 for validation after clinical applications. The 4211 data items were extracted from the EHR system and delirium was measured using CAM-ICU (Confusion Assessment Method for Intensive Care Unit). The potential predictors were selected and a logistic regression model was established to create a delirium risk scoring algorithm to construct the Auto-DelRAS. The Auto-DelRAS was evaluated at three months and one year after its application to clinical practice to establish the predictive validity of the system. Eleven predictors were finally included in the logistic regression model. The results of the Auto-DelRAS risk assessment were shown as high/moderate/low risk on a Kardex screen. The predictive validity, analyzed after the clinical application of Auto-DelRAS after one year, showed a sensitivity of 0.88, specificity of 0.72, positive predictive value of 0.53, negative predictive value of 0.94, and a Youden index of 0.59. A relatively high level of predictive validity was maintained with the Auto-DelRAS system, even one year after it was applied to clinical practice. Copyright © 2017. Published by Elsevier Ltd.

La utilizacion de los mapas conceptuales en la ensenanza de biologia y su efecto sobre el dominio del proceso de fotosintesis en los estudiantes universitarios

NASA Astrophysics Data System (ADS)

Gonzalez Rivera, Maria M.

Se investigo el efecto de los mapas conceptuales sobre el dominio del proceso de fotosintesis en estudiantes universitarios. La investigacion utilizo dos estrategias: mapas conceptuales individuales y mapas conceptuales colaborativos, con el fin de investigar si existen diferencias significativas en el dominio del proceso de fotosintesis. El analisis de los datos incluyo aspectos cualitativos y cuantitativos. Se desprende del estudio que el 80% de los estudiantes describen la utilizacion de los mapas conceptuales como una experiencia beneficiosa. El 70% de los estudiantes expreso que los mapas conceptuales son utiles en el aprendizaje del proceso de fotosintesis y el 61% indico que facilitan la comprension de los conceptos. Los hallazgos mas importantes del analisis cuantitativo indican que los estudiantes que utilizaron los mapas conceptuales mejoraron significativamente su desempeno en la posprueba global. Se utilizo la prueba Mann-Whitney para investigar si existian diferencias significativas en la posprueba y preprueba global, el valor de W = 1945.0, para un valor p de 0.00, lo cual establece diferencias significativas. Para determinar si existian diferencias significativas entre la posprueba y preprueba del grupo individual, se realizo la prueba nuevamente. El valor de W correspondio a 490.5, que es significativo, con un valor p de 0.00. Se concluye que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo individual. Los datos proveen suficiente evidencia para sostener que los estudiantes que utilizaron la estrategia de mapas conceptuales individuales mejoraron el dominio del proceso de fotosintesis significativamente. Se realizo nuevamente la prueba para los resultados de posprueba y preprueba del grupo colaborativo. El valor de W correspondio a 446 con un valor p de 0.00. Se concluyo que existen diferencias significativas entre la ejecucion de la posprueba y preprueba del grupo colaborativo. Finalmente, se efectuo una

Reinstatement of the genus Colopalpus Pritchard and Baker (1958) and re-description of Colopalpus matthyssei Pritchard and Baker (1958), the type species of this genus (Acari, Tenuipalpidae)

USDA-ARS?s Scientific Manuscript database

Pritchard and Baker (1958) erected the genus Colopalpus with Tenuipalpus matthyssei (Pritchard and Baker) a species described from Laguna, The Philippines, as the type species. Meyer (1979) treated the genus as a junior synonym of Tenuipalpus Donnadieu. In this paper, we re-describe the female, male...

Western dwarf mistletoe infects understory Jeffrey pine seedlings on Cleveland National Forest, California

Treesearch

Robert F. Scharpf; Detlev Vogler

1986-01-01

Many young, understory Jeffrey pines (Pinus jeffreyi Grev. & Balf.) were found to be infected by western dwarf mistletoe (Arceuthobium campylopodum Engelm.) on Laguna Mountain, Cleveland National Forest, in southern California. Under heavily infected overstory, about three-fourths of the young pines (about 15 years old on the...

Evaluation of the Teaching Performance of University Lecturers: Comparison between Mexico and Spain

ERIC Educational Resources Information Center

Diaz, Matilde; Borges, Africa; Valadez, Dolores; Zambrano, Rogelio

2015-01-01

Comparative educational studies allow the study of the differences and similarities between different educational systems. This research, which consists on an educational evaluation, has studied the teaching behavior of ten university lecturers from a Spanish university--the University of La Laguna--, and seven from a Mexican…

COASTAL BEND BAYS & ESTUARIES PROGRAM IMPLEMENTATION REVIEW 2004

EPA Science Inventory

The Coastal Bend Bays & Estuaries Program, Inc. (CBBEP) is a nonprofit 501(c)(3)organization. The CBBEP project area encompasses 12 counties coincident with the Coastal Bend Council of Governments and extends from the Land-Cut in the Laguna Madre, through the Corpus Christi Bay s...

Pollen collection and honey bee forager distribution in cantaloupe

USDA-ARS?s Scientific Manuscript database

Honey bee (Apis mellifera, L.) pollen collection and forager distribution were examined during the summer of 2002 in a cantaloupe (Cucumis melo, L., Cruiser cv.) field provided with plastic mulch and drip irrigation. The experimental site was located near the INIFAP Campo Experimental La Laguna, Ma...

Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas

NASA Astrophysics Data System (ADS)

Landau, S. J.; Sisterna, P. D.; Vucetich, H.

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

Enrichments of the mantle sources beneath the Southern Volcanic Zone (Andes) by fluids and melts derived from abraded upper continental crust

NASA Astrophysics Data System (ADS)

Holm, Paul Martin; Søager, Nina; Dyhr, Charlotte Thorup; Nielsen, Mia Rohde

2014-05-01

Mafic basaltic-andesitic volcanic rocks from the Andean Southern Volcanic Zone (SVZ) exhibit a northward increase in crustal components in primitive arc magmas from the Central through the Transitional and Northern SVZ segments. New elemental and Sr-Nd-high-precision Pb isotope data from the Quaternary arc volcanic centres of Maipo (NSVZ) and Infernillo and Laguna del Maule (TSVZ) are argued to reflect mainly their mantle source and its melting. For the C-T-NSVZ, we identify two types of source enrichment: one, represented by Antuco in CSVZ, but also present northward along the arc, was dominated by fluids which enriched a pre-metasomatic South Atlantic depleted MORB mantle type asthenosphere. The second enrichment was by melts having the characteristics of upper continental crust (UCC), distinctly different from Chile trench sediments. We suggest that granitic rocks entered the source mantle by means of subduction erosion in response to the northward increasingly strong coupling of the converging plates. Both types of enrichment had the same Pb isotope composition in the TSVZ with no significant component derived from the subducting oceanic crust. Pb-Sr-Nd isotopes indicate a major crustal compositional change at the southern end of the NSVZ. Modelling suggests addition of around 2 % UCC for Infernillo and 5 % for Maipo.

Pre-Hispanic agricultural decline prior to the Spanish Conquest in southern Central America

NASA Astrophysics Data System (ADS)

Taylor, Zachary P.; Horn, Sally P.; Finkelstein, David B.

2013-08-01

Archeological and paleoenvironmental records from southern Central America attribute population collapse to the Spanish Conquest about 500 years ago. Paleoclimate records from the circum-Caribbean have shown evidence of severe, regional droughts that contributed to the collapse of the Mayan Civilization, but there are few records of these droughts in southern Central America and no records of their effects on prehistoric populations in the region. Here we present a high-resolution lake sediment record of prehistoric agricultural activities using bulk sediment stable carbon isotopes from Laguna Zoncho, Costa Rica. We find isotopic evidence that agriculture was nearly absent from the watershed approximately 220 years prior to the Spanish arrival in Costa Rica and identify two distinct periods of agricultural decline, 1150-970 and 860-640 cal yr BP, which correspond to severe droughts in central Mexico. We attribute decreases in agriculture to a weakened Central American monsoon, which would have shortened the growing season at Laguna Zoncho, reduced crop yields, and negatively affected prehistoric populations.

Inverse modeling of groundwater flow in the semiarid evaporitic closed basin of Los Monegros, Spain

NASA Astrophysics Data System (ADS)

Samper-Calvete, F. J.; García-Vera, M. A.

Monegros en la que existen toda una serie de lagunas salinas. La implantación del regadío en esta zona puede alterar el régimen hidrológico de las lagunas, provocar problemas de salinización de suelos y aguas y aumentar la salinidad del río Ebro. Con el fin de evaluar estos efectos se construyó un modelo numérico del flujo subterráneo. Con la información disponible se pueden distinguir dos acuíferos que están conectados mediante un acuitardo. El modelo de flujo se calibró en régimen estacionario utilizando el procedimiento de calibración automática de Carrera y Neuman (1986a) basado en el método de la máxima verosimilitud. El modelo finalmente calibrado es capaz de reproducir los niveles piezométricos medidos y es coherente con los resultados de los balances hidrológicos en las lagunas. La conductividad hidráulica media del modelo es superior en casi dos órdenes de magnitud a la media de las conductividades hidráulicas obtenidas en ensayos de campo a escala local. Este efecto de escala en la conductividad hidráulica es coherente con los resultados de Neuman (1994) y Sánchez-Vila et al. (1996) y confirma que dicho efecto también se observa en medios evaporíticos.

History and use of del Nido cardioplegia solution at Boston Children's Hospital.

PubMed

Matte, Gregory S; del Nido, Pedro J

2012-09-01

Cardioplegia is an integral and essential method of myocardial protection for patients of all ages requiring cardiac surgery in which the heart must be stopped. Numerous cardioplegia solutions and delivery methods have been developed. The del Nido cardioplegia solution has been in use for 18 years at Boston Children's Hospital. This is a unique four parts crystalloid to one part whole blood formulation that is generally used in a single-dose fashion. Although the formulation was originally developed for use in pediatric and infant patients, its use for adult cardiac surgery has been expanding. National and international inquiries to our institution regarding this cardioplegia have been increasing over the last 2 years. We present the developmental history, supporting theory, and current protocol for use of what is now referred to as del Nido cardioplegia.

F508del-CFTR rescue: a matter of cell stress response.

PubMed

Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

2013-01-01

Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature.

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

PubMed Central

Chothani, Daya L.; Vaghasiya, H. U.

2011-01-01

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.

NASA Astrophysics Data System (ADS)

Muñoz-Caro, Guillermo Manuel

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 μm, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Meningiomas del foramen magno: Reporte de 12 casos y revisión de la literatura

PubMed Central

Campero, Álvaro; Ajler, Pablo; Roman, Guillermo; Rivadeneira, Conrado

2017-01-01

Resumen Objetivo: El propósito del presente trabajo es presentar los resultados de 12 pacientes con diagnóstico de meningiomas del foramen magno (MFM), de localización anterior o lateral, operados con técnicas microquirúrgicas. Método: Desde Junio de 2005 a Diciembre de 2016, 12 pacientes con diagnóstico de MFM fueron intervenidos quirúrgicamente. Se evaluó: edad, sexo, localización de la lesión (anterior o lateral), sintomatología, tipo de abordaje utilizado y resultados postoperatorios. Resultados: De los pacientes intervenidos, 8 fueron mujeres y 4 varones. La edad promedio fue de 47 años. La localización fue anterior en 8 casos y lateral en 4 casos. La sintomatología más frecuente fue dolor occipito-cervical (8 casos), seguido de tetraparesia (3 casos). En los pacientes con MFM de localización anterior se realizó un abordaje extremo-lateral transcondilar (ELTC), mientras que en los tumores laterales el abordaje fue extremo-lateral retrocondilar (ELRC). En 10 casos la resección fue completa. En dos pacientes fue necesario dejar una pequeña lámina de meningioma sobre la arteria vertebral y a nivel del foramen yugular. Como complicaciones postoperatorias, 3 pacientes presentaron una paresia del XII nervio craneano y 2 pacientes paresia del XI nervio craneano; además, 1 paciente presentó una fístula de LCR. Conclusión: La cirugía de los MFM de localización anterior y lateral puede ser realizada de forma segura y efectiva. Es necesario: a) buen conocimiento anatómico de la región; b) disecar los músculos de la nuca en 2 planos, exponiendo el triángulo suboccipital y la arteria vertebral (AV); 3) realizar un abordaje ELRC en los tumores laterales, y ELTC en los tumores anteriores; y 4) buena técnica microquirúrgica. PMID:29142778

Contribución al flujo infrarrojo de las estrellas Be de la recombinación dielectrónica del MgII

NASA Astrophysics Data System (ADS)

Cruzado, A.; di Rocco, H.; Ringuelet, A.

Para evaluar la contribución del proceso de recombinación dielectrónica del átomo de MgII al exceso de flujo infrarrojo observado en las estrellas Be, calculamos la energía emitida en las líneas originadas por este proceso. Se evaluaron los efectos de las condiciones físicas del medio, como la temperatura electrónica y la densidad electrónica, sobre el flujo emitido. Se consideró también la influencia de una posible opacidad.

Synthetic Spectral Analysis of the Far Ultraviolet Spectra of the Old Nova HR Del

NASA Astrophysics Data System (ADS)

Robertson, Jordan; Sion, E.

2012-05-01

We present a synthetic spectral analysis of the archival IUE far ultraviolet spectra of the post-nova, HR Del (Nova Del 1967). The system has an estimated white dwarf mass of 0.55 Msun (Ritter and Kolb 2003), orbital period P_orb = 0.214165 days, estimated orbital inclination of 40 degrees (Keurster 1988) and distance determinations in the literature ranging from 970 pc to 285 pc. The spectra reveal P Cygni profiles indicative of wind outflow from the disk and closely resemble the IUE spectra of UX UMa nova-likes, which have never had recorded outbursts. We de-reddened the archival IUE spectra using E(B-V) = 0.16. Our synthetic spectral analysis utilized optically thick, steady state accretion disk models and white dwarf model atmospheres that we constructed using TLUSTY and SYNSPEC (Hubeny 1988, Hubeny and Lanz (1995). Our input parameters were the white dwarf mass, inclination and a range of accretion rates for which we found the best-fitting model. We report the results of our model fitting and compare HR Del with other post-novae at comparable times past their nova outburst. This work was supported by NSF grant 0807892 to Villanova University

La meridiana di Egnazio Danti nella Torre dei Venti in Vaticano: un'icona della riforma Gregoriana del calendario

NASA Astrophysics Data System (ADS)

Sigismondi, Costantino

2014-05-01

La Torre dei Venti domina l’angolo Sud Ovest del cortile della Pigna (nell'area dei Musei Vaticani), ed è inclusa negli ambienti dell'Archivio Segreto Vaticano. Non è aperta al pubblico, ma è universalmente nota per la fama che da oltre quattrocento anni la circonda, legata alle vicende della riforma Gregoriana del calendario. La meridiana tracciata da padre Egnazio Danti (1536-1586) nella torre dei Venti, fu visitata anche da Gregorio XIII, probabilmente il 21 marzo 1581 come suppone il padre Stein, per convincersi dell'anticipo ormai arrivato a dieci giorni dell'equinozio di primavera sulla data che il concilio di Nicea aveva fissato al 21 marzo per il computo pasquale. La ricognizione astrometrica del febbraio-marzo 2009 fatta dall'autore viene qui presentata.

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

PubMed

Chung, W Joon; Goeckeler-Fried, Jennifer L; Havasi, Viktoria; Chiang, Annette; Rowe, Steven M; Plyler, Zackery E; Hong, Jeong S; Mazur, Marina; Piazza, Gary A; Keeton, Adam B; White, E Lucile; Rasmussen, Lynn; Weissman, Allan M; Denny, R Aldrin; Brodsky, Jeffrey L; Sorscher, Eric J

2016-01-01

Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) comprise an important therapeutic strategy for cystic fibrosis lung disease. However, compounds that rescue the F508del mutant protein to wild type (WT) levels have not been identified. In this report, we consider obstacles to obtaining robust and therapeutically relevant levels of F508del CFTR. For example, markedly diminished steady state amounts of F508del CFTR compared to WT CFTR are present in recombinant bronchial epithelial cell lines, even when much higher levels of mutant transcript are present. In human primary airway cells, the paucity of Band B F508del is even more pronounced, although F508del and WT mRNA concentrations are comparable. Therefore, to augment levels of "repairable" F508del CFTR and identify small molecules that then correct this pool, we developed compound library screening protocols based on automated protein detection. First, cell-based imaging measurements were used to semi-quantitatively estimate distribution of F508del CFTR by high content analysis of two-dimensional images. We evaluated ~2,000 known bioactive compounds from the NIH Roadmap Molecular Libraries Small Molecule Repository in a pilot screen and identified agents that increase the F508del protein pool. Second, we analyzed ~10,000 compounds representing diverse chemical scaffolds for effects on total CFTR expression using a multi-plate fluorescence protocol and describe compounds that promote F508del maturation. Together, our findings demonstrate proof of principle that agents identified in this fashion can augment the level of endoplasmic reticulum (ER) resident "Band B" F508del CFTR suitable for pharmacologic correction. As further evidence in support of this strategy, PYR-41-a compound that inhibits the E1 ubiquitin activating enzyme-was shown to synergistically enhance F508del rescue by C18, a small

Updated Distribution Records for Anopheles vagus (Diptera: Culicidae) in the Republic of Philippines, and Considerations Regarding Its Secondary Vector Roles in Southeast Asia

DTIC Science & Technology

2011-01-01

larvae were collected from three habitats (rice fields, irrigation ditches and drainage ditches) in Laguna Province in July 2002 using a plastic dipper ...Wilkerson et al. (2003). The rDNA ITS2 was amplified, and polymerase chain reaction (PCR) products were directly sequenced using Big Dye 3.0 (Applied

Overwash Processes and Foredune Ecology, Nauset Spit, Massachusetts.

DTIC Science & Technology

1984-12-01

played a major role in the infilling of Laguna Madre behind Padre Island, Texas. Washover deposits were subsequently reworked by the wind, which...flowering grass that establishes mats of vegetation in the high marsh. Spa-tin patens var. monogyna is erect, somewhat taller , later flowering, and grows in

Cayler cardiofacial syndrome and del 22q11: Part of the CATCH22 phenotype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giannotti, A.; Digilio, M.C.; Marino, B.

1994-11-15

The authors report evidence supporting the hypothesis that del(22)(q11) can be a pathogenetic mechanism for the association between hypoplasia of the depressor anguli oris muscle (DAOM) and conotruncal cardiac malformations. A series of over 180 patients was investigated with deletions of 22q11 with conotruncal defects. About 2/3 of these patients had isolated, nonfamilial cardiac defects. Hemizygosity was searched using the HD7k probe and densitometric analysis. In the patients with molecular evidence of del(22)(q11), hemizygosity was confirmed also using fluorescence in situ hybridization (FISH) with SC11.1 probe. No deletion was found in the parents of hemizygous patients. 16 refs.

[Tierra del Fuego: the scientific-political construction of exclusion and counter-image of the ideal city dweller].

PubMed

Nacach, Gabriela

2012-01-01

Due to its late incorporation into the national State, the social, economic and political setting of the Argentine province Tierra del Fuego differed from that of the rest of the national territory. In the construction of dependent otherness, objectifications and representations were imposed by state-related and non-state-related institutions, among other agencies. In this context, the Salesian mission of La Candelaria and Ushuaia's Jail for recidivists stand out as spaces in which biopolitics was concretised. The native population and criminals in Tierra del Fuego were those to be subjugated. The thesis of the extinction of the Indian and the simultaneous exaltation of the criminal as the subject of progress identified the scientific and political mechanisms by which the exclusion of certain social groups (Tierra del Fuego's indigenous population) and the inclusion of others (criminals) were regulated.

Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.

PubMed

Chandran, Divya; Rickert, Joshua; Huang, Yingxiang; Steinwand, Michael A; Marr, Sharon K; Wildermuth, Mary C

2014-04-09

In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves. Copyright © 2014 Elsevier Inc. All rights reserved.

Taos Smart Growth Implementation Assistance: Concepts for the Paseo del Pueblo Sur Corridor

EPA Pesticide Factsheets

This report describes a technical assistance project with Taos, NM, to help make development along State Highway 68, the Paseo del Pueblo Sur commercial corridor, economically stronger and more attractive.

Analysis of density and epitopes of D antigen on the surface of erythrocytes from DEL phenotypic individuals carrying the RHD1227A allele.

PubMed

Gu, Juan; Sun, An-Yuan; Wang, Xue-Dong; Shao, Chao-Peng; Li, Zheng; Huang, Li-Hua; Pan, Zhao-Lin; Wang, Qing-Ping; Sun, Guang-Ming

2014-04-01

The characteristics of the D antigen are important as they influence the immunogenicity of D variant cells. Several studies on antigenic sites have been reported in normal D positive, weak D and partial D cases, including a comprehensive analysis of DEL types in Caucasians. The aim of this study was to assess D antigen density and epitopes on the erythrocyte surface of Asian type DEL phenotypic individuals carrying the RHD1227A allele in the Chinese population. A total of 154 DEL phenotypic individuals carrying the RHD1227A allele were identified through adsorption and elution tests and polymerase chain reaction analysis with sequence-specific primers in the Chinese population. D antigen density on the erythrocyte surface of these individuals was detected using a flow cytometric method. An erythrocyte sample with known D antigen density was used as a standard. Blood samples from D-negative and D-positive individuals were used as controls. In addition, D antigen epitopes on the erythrocyte surface of DEL individuals carrying the RHD1227A allele were investigated with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. The means of the median fluorescence intensity of D antigen on the erythrocyte membrane surface of D-negative, D-positive and DEL individuals were 2.14±0.25, 193.61±11.43 and 2.45±0.82, respectively. The DEL samples were estimated to have approximately 22 D antigens per cell. The samples from all 154 DEL individuals reacted positively with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. In this study, D antigen density on the erythrocyte surface of DEL individuals carrying the RHD1227A allele was extremely low, there being only very few antigenic molecules per cell, but the D antigen epitopes were grossly complete.

Tratamiento Quirúrgico de los Meningiomas del Foramen Óptico, Técnicay Resultados de una Serie de 18 Pacientes

PubMed Central

Goldschmidt, Ezequiel; Ajler, Pablo; Campero, Álvaro; Landriel, Federico; Sposito, Maximiliano; Carrizo, Antonio

2014-01-01

Introducción: los meningiomas del foramen óptico producen un rápido deterioro de la función visual aún cuando su tamaño es pequeño, por eso su diagnóstico y manejo difiere del resto de los meningiomas clinoideos. El propósito de este estudio es presentar la técnica y los resultados de nuestro manejo quirúrgico de meningiomas foraminales (MF). Pacientes y Métodos: se llevó a cabo una revisión de las historias clínicas de 47 pacientes con meningiomas primarios intraorbitarios. Se realizaron 52 cirugías en los pacientes con MF. Se empleó una craneotomía fronto-orbitaria, seguida de una descompresión extradural del canal óptico, resección del componente intraorbitario y exploración intradural del nervio óptico. Resultados: de los 12 pacientes con MF que presentaban la visión conservada, la agudeza visual fue preservada en 7 casos, mejoró en 2, y empeoró en 3. En 18 pacientes, el principal síntoma fue exoftalmos y en 35 pacientes ceguera unilateral. Ocurrieron 6 recurrencias, 2 a 10 años después de la resección quirúrgica. Cinco de ellos fueron reoperados. Se indicó radioterapia después de la recurrencia en 3 pacientes. Conclusión: el manejo de los MF continúa siendo controvertido y frecuentemente se propone un tratamiento conservador. Basados en nuestros hallazgos de frecuente extensión intracraneal, proponemos realizar una resección total o subtotal del tumor, preservando el nervio óptico en pacientes con visión prequirúrgica conservada. PMID:25165616

Heat flow and thermal processes in the Jornada delMuerto, New Mexico

NASA Technical Reports Server (NTRS)

Reiter, M.

1985-01-01

Most heat flow data in rifts are uncertain largely because of hydrologic disturbances in regions of extensive fracturing. Estimates of heat flow in deep petroleum tests within a large basin of the Rio Grande rift, which has suffered little syn-rift fracturing, may begin to provide clearer insight into the relationships between high heat flow and crustal thinning processes. The Jornada del Muerto is a large basin located in the Rio Grande rift of south central New Mexico. The region of interest within the Jornada del Muerto is centered about 30 km east of the town of Truth or Consequences, and is approximately 60 km north-south by 30 km east-west. High heat flows are estimated for the region. Values increase from about 90 mWm(-2) in the northern part of the study area to about 125 mWm(-2) in the southern part. These high heat flows are rather enigmatic because in the immediate vicinities of the sites there is little evidence of Cenozoic volcanism or syn-rift extensional tectonics. It is suggested that the geothermal anomaly in the southern Jornada del Muerto (approx. 125 to approx. 95 mWm(-2) results from some type of mass movement-heat transfer mechanism operating in the crust just below the elastic layer. This conclusion is consistent with the geologic and geophysical data which describe a thin crust, apparently devoid of features indicative of extensional-tectonics in the upper part of the lastic crust.

Cambios históricos en el aporte terrígeno de la cuenca del Río de la Plata sobre la plataforma interna Uruguaya

NASA Astrophysics Data System (ADS)

Marrero, Analía; Tudurí, Adriana; Pérez, Laura; Cuña, Caroline; Muniz, Pablo; Lopes Figueira, Rubens; Michaelovitch de Mahiques, Michel; Alves de Lima Ferreira, Paulo; Pittauerová, Daniela; Hanebuth, Till; García Rodríguez, Felipe

2014-12-01

El Río de la Plata (RdlP) presenta significativas variaciones naturales (hidrodinámicas y oceanográficas) asociadas a diferentes condiciones climáticas. El propósito de este trabajo es inferir los cambios de aportes continentales de sedimentos y su relación con las variaciones hidrológicas del Río de la Plata, a través del análisis de proxies sedimentológicos y geoquímicos en testigos de sedimentos de la plataforma interna uruguaya que registran los últimos 100 años, aproximadamente. A partir de la datación por 210Pb de dos testigos de sedimentos (GeoB 13813-4 y BAR1) se reconstruyó la geocronología del ambiente, y se relacionó con datos de las forzantes climáticas Pacific Decadal Oscillation, El Niño/La Niña Southern Oscillation, Atlantic Multidecadal Oscillation, y las anomalías hidrológicas de los ríos Paraná y Uruguay. Los valores más positivos y estables del Southern Oscillation Index, los cuales corresponden a fases La Niña, se observan en el periodo correspondiente entre 1910-1970, respecto al resto de la serie, donde se aprecia una mayor variabilidad y una tendencia hacia valores más negativos (eventos El Niño). Se hicieron dendrogramas (clustering) jerárquicos para ambos testigos. Para el testigo GeoB 13813-4, se utilizó la relación Ca/Ti y la granulometría, mientras que para BAR1 se recurrió a variables granulométricas y la tasa de sedimentación. El mayor aporte continental hacia la región de la plataforma adyacente al Río de la Plata registrado a partir del año 1970, podría ser el factor principal de los agrupamientos observados en los clusters para ambos testigos. Las agrupaciones mostraron una diferenciación en la década de 1970, lo que estaría asociado al aumento de los caudales de los ríos Paraná y Uruguay, durante las últimas tres décadas del siglo XX. Por otra parte se observa que la granulometría del testigo BAR1 presentó un mayor tamaño de grano y más variabilidad que en el caso del testigo Geo

Prevalence of 185delAG and 5382insC mutations in BRCA1, and 6174delT in BRCA2 in women of Ashkenazi Jewish origin in southern Brazil

PubMed Central

Dillenburg, Crisle Vignol; Bandeira, Isabel Cristina; Tubino, Taiana Valente; Rossato, Luciana Grazziotin; Dias, Eleonora Souza; Bittelbrunn, Ana Cristina; Leistner-Segal, Sandra

2012-01-01

Certain mutations in BRCA1 and BRCA2 genes are frequent in the Ashkenazi Jewish population. Several factors contribute to this increased frequency, including consanguineous marriages and an event known as a “bottleneck”, which occurred in the past and caused a drastic reduction in the genetic variability of this population. Several studies were performed over the years in an attempt to elucidate the role of BRCA1 and BRCA2 genes in susceptibility to breast cancer. The aim of this study was to estimate the carrier frequency of certain common mutations in the BRCA1 (185delAG and 5382insC) and BRCA2 (6174delT) genes in an Ashkenazi Jewish population from Porto Alegre, Brazil. Molecular analyses were done by PCR followed by RFLP (ACRS). The carrier frequencies for BRCA1 185delAG and 5382insC were 0.78 and 0 respectively, and 0.4 for the BRCA2 6174deT mutation. These findings are similar to those of some prior studies but differ from others, possibly due to excluding individuals with a personal or family history of cancer. Our sample was drawn from the community group and included individuals with or without a family or personal history of cancer. Furthermore, increased dispersion among Ashkenazi subpopulations may be the result of strong genetic drift and/or admixture. It is therefore necessary to consider the effects of local admixture on the mismatch distributions of various Jewish populations. PMID:23055798

Prevalence of 185delAG and 5382insC mutations in BRCA1, and 6174delT in BRCA2 in women of Ashkenazi Jewish origin in southern Brazil.

PubMed

Dillenburg, Crisle Vignol; Bandeira, Isabel Cristina; Tubino, Taiana Valente; Rossato, Luciana Grazziotin; Dias, Eleonora Souza; Bittelbrunn, Ana Cristina; Leistner-Segal, Sandra

2012-07-01

Certain mutations in BRCA1 and BRCA2 genes are frequent in the Ashkenazi Jewish population. Several factors contribute to this increased frequency, including consanguineous marriages and an event known as a "bottleneck", which occurred in the past and caused a drastic reduction in the genetic variability of this population. Several studies were performed over the years in an attempt to elucidate the role of BRCA1 and BRCA2 genes in susceptibility to breast cancer. The aim of this study was to estimate the carrier frequency of certain common mutations in the BRCA1 (185delAG and 5382insC) and BRCA2 (6174delT) genes in an Ashkenazi Jewish population from Porto Alegre, Brazil. Molecular analyses were done by PCR followed by RFLP (ACRS). The carrier frequencies for BRCA1 185delAG and 5382insC were 0.78 and 0 respectively, and 0.4 for the BRCA2 6174deT mutation. These findings are similar to those of some prior studies but differ from others, possibly due to excluding individuals with a personal or family history of cancer. Our sample was drawn from the community group and included individuals with or without a family or personal history of cancer. Furthermore, increased dispersion among Ashkenazi subpopulations may be the result of strong genetic drift and/or admixture. It is therefore necessary to consider the effects of local admixture on the mismatch distributions of various Jewish populations.

High precision ages from the Torres del Paine Intrusion, Chile

NASA Astrophysics Data System (ADS)

Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.

2006-12-01

The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic

77 FR 15800 - Notice of Inventory Completion: U.S. Fish and Wildlife Service, Southwest Regional Office...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... professional staff in consultation with the Hopi Tribe of Arizona; Pueblo of Acoma, New Mexico; Pueblo of Cochiti, New Mexico; Pueblo of Isleta, New Mexico; Pueblo of Jemez, New Mexico; Pueblo of Laguna, New Mexico; Pueblo of Nambe, New Mexico; Pueblo of Picuris, New Mexico; Pueblo of Pojoaque, New Mexico...

Contributions to the study of gasteromycetes of Puerto Rico

Treesearch

Angel M. Nieves-Rivera; D. Jean. Lodge; Orson K. Miller

1998-01-01

Battarrea stevenii and Tulostoma cf. meridionale, two cosmopolitan taxa are reported as new records for Puerto Rico. Both species were collected from the same disturbed subtropical dry forested area. A partial checklist of the taxa of macromycetes collected from Boquer*on Commonwealth- and Laguna Cartagena National Wildlife Refuges is also provided.

Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama

USGS Publications Warehouse

Lovelock, C.E.; Feller, Ilka C.; McKee, K.L.; Thompson, R.

2005-01-01

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.

PubMed

Adank, Muriel A; Jonker, Marianne A; Kluijt, Irma; van Mil, Saskia E; Oldenburg, Rogier A; Mooi, Wolter J; Hogervorst, Frans B L; van den Ouweland, Ans M W; Gille, Johan J P; Schmidt, Marjanka K; van der Vaart, Aad W; Meijers-Heijboer, Hanne; Waisfisz, Quinten

2011-12-01

Mutations in the CHEK2 gene confer a moderately increased breast cancer risk. The risk for female carriers of the CHEK2*1100delC mutation is twofold increased. Breast cancer risk for carrier women is higher in a familial breast cancer setting which is due to coinheritance of additional genetic risk factors. This study investigated the occurrence of homozygosity for the CHEK2*1100delC allele among familial breast cancer cases and the associated breast cancer risk. Homozygosity for the CHEK2*1100delC allele was identified in 8/2554 Dutch independent familial non-BRCA1/2 breast cancer cases. The genotype relative risk for breast cancer of homozygous and heterozygous familial breast cancer cases was 101.34 (95% CI 4.47 to 121 000) and 4.04 (95% CI 0.88 to 21.0), respectively. Female homozygotes appeared to have a greater than twofold increased breast cancer risk compared to familial CHEK2*1100delC heterozygotes (p=0.044). These results and the occurrence of multiple primary tumours in 7/10 homozygotes indicate a high cancer risk in homozygous women from non-BRCA1/2 families. Intensive breast surveillance is therefore justified in these homozygous women. It is concluded that diagnostic testing for biallelic mutations in CHEK2 is indicated in non-BRCA1/2 breast cancer families, especially in populations with a relatively high prevalence of deleterious mutations in CHEK2.

Optimal time travel in the Gödel universe

NASA Astrophysics Data System (ADS)

Natário, José

2012-04-01

Using the theory of optimal rocket trajectories in general relativity, recently developed in Henriques and Natário (2011), we present a candidate for the minimum total integrated acceleration closed timelike curve in the Gödel universe, and give evidence for its minimality. The total integrated acceleration of this curve is lower than Malament's conjectured value (Malament 1984), as was already implicit in the work of Manchak (Gen. Relativ. Gravit. 51-60, 2011); however, Malament's conjecture does seem to hold for periodic closed timelike curves.

78 FR 74008 - Amendment of Class E Airspace; Del Rio, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

... Laughlin Air Force Base (AFB). The FAA is taking this action to enhance the safety and management of... at Laughlin AFB, Del Rio, TX. An additional segment to the north is needed to contain approach category E military aircraft conducting circling approaches to the airport, to retain the safety and...

From badge of pride to cause of stigma: combatting mal del pinto in Mexico.

PubMed

Carrillo, Ana María

2013-03-01

Mal del pinto is a dermatological disease characterized by discoloured patches of skin on the face and body. It has been present in what is now the territory of Mexico from before the Spanish conquest up to recent times. Though early concerns for mal del pinto as a public health problem can be traced back to the late 19th century, no campaign to combat the disease was undertaken until the second half of the 20th. Thanks to the effectiveness of treatment with penicillin, the fight against this illness--which was once assumed as a symbol of pride--enjoyed a broader acceptance among the population that other health campaigns. Copyright © 2013 Elsevier Ltd. All rights reserved.

Simulation of flow in the upper North Coast Limestone Aquifer, Manati-Vega Baja area, Puerto Rico

USGS Publications Warehouse

Cherry, Gregory S.

2001-01-01

A two-dimensional computer ground-water model was constructed of the Manati-Vega Baja area to improve the understanding of the unconfined upper aquifer within the North Coast Province of Puerto Rico. The modeled area covers approximately 79 square miles within the municipios of Manati and Vega Baja and small portions of Vega Alta and Barceloneta. Steady-state two-dimensional ground-water simulations were correlated to conditions prior to construction of the Laguna Tortuguero outlet channel in 1940 and calibrated to the observed potentiometric surface in March 1995. At the regional scale, the unconfined Upper North Coast Limestone aquifer is a diffuse ground-water flow system through the Aguada and Aymamon limestone units. The calibrated model input parameters for aquifer recharge varied from 2 inches per year in coastal areas to 18 inches per year in the upland areas south of Manati and Vega Baja. The calibrated transmissivity values ranged from less than 500 feet squared per day in the upland areas near the southern boundary to 70,000 feet squared per day in the areas west of Vega Baja. Increased ground-water withdrawals from 1.0 cubic foot per second for 1940 conditions to 26.3 cubic feet per second in 1995, has reduced the natural ground-water discharge to springs and wetland areas, and induced additional recharge from the rivers. The most important regional drainage feature is Laguna Tortuguero, which is the major ground-water discharge body for the upper aquifer, and has a drainage area of approximately 17 square miles. The discharge to the sea from Laguna Tortuguero through the outlet channel has been measured on a bi-monthly basis since 1974. The outflow represents a combination of ground- and surface-water discharge over the drainage area. Hydrologic conditions, prior to construction of the Laguna Tortuguero outlet channel in 1943, can be considered natural conditions with minimal ground-water pumpage (1.0 cubic foot per second), and heads in the lagoon

Descripción del coronógrafo a ser instalado en Argentina (MICA)

NASA Astrophysics Data System (ADS)

Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

77 FR 4897 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

...-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, VA AGENCY: Coast... provide for the safety of life on navigable waters during the live-fire gun exercises on the M/V Del Monte... associated with the live-fire gun exercise. DATES: This rule is effective in the CFR on February 1, 2012...

76 FR 31848 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, Virginia

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, Virginia AGENCY... provide for the safety of life on navigable waters during the live-fire gun exercises on the M/V Del Monte... associated with the live-fire gun exercise. DATES: This rule will be effective from 11 a.m. June 6, 2011...

The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.

PubMed

Bertrand, Carol A; Mitra, Shalini; Mishra, Sanjay K; Wang, Xiaohui; Zhao, Yu; Pilewski, Joseph M; Madden, Dean R; Frizzell, Raymond A

2017-06-01

Several members of the SLC26A family of anion transporters associate with CFTR, forming complexes in which CFTR and SLC26A functions are reciprocally regulated. These associations are thought to be facilitated by PDZ scaffolding interactions. CFTR has been shown to be positively regulated by NHERF-1, and negatively regulated by CAL in airway epithelia. However, it is unclear which PDZ-domain protein(s) interact with SLC26A9, a SLC26A family member found in airway epithelia. We have previously shown that primary, human bronchial epithelia (HBE) from non-CF donors exhibit constitutive anion secretion attributable to SLC26A9. However, constitutive anion secretion is absent in HBE from CF donors. We examined whether changes in SLC26A9 constitutive activity could be attributed to a loss of CFTR trafficking, and what role PDZ interactions played. HEK293 coexpressing SLC26A9 with the trafficking mutant F508del CFTR exhibited a significant reduction in constitutive current compared with cells coexpressing SLC26A9 and wt CFTR. We found that SLC26A9 exhibits complex glycosylation when coexpressed with F508del CFTR, but its expression at the plasma membrane is decreased. SLC26A9 interacted with both NHERF-1 and CAL, and its interaction with both significantly increased with coexpression of wt CFTR. However, coexpression with F508del CFTR only increased SLC26A9's interaction with CAL. Mutation of SLC26A9's PDZ motif decreased this association with CAL, and restored its constitutive activity. Correcting aberrant F508del CFTR trafficking in CF HBE with corrector VX-809 also restored SLC26A9 activity. We conclude that when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. Copyright © 2017 the American Physiological Society.

Evaluation of HLA-G 14-bp ins/del and +3142G>C polymorphisms with susceptibility to recurrent spontaneous abortion.

PubMed

Hashemi, Mohammad; Mokhtari, Mojgan; Khazaeian, Safura; Bahari, Gholamreza; Rezaei, Maryam; Nakhaee, Alireza; Taheri, Mohsen

2017-06-01

HLA-G is critically important for successful implantation during pregnancy. Increasing evidence supposed that HLA-G plays a key role in tolerance of the semi-allogeneic graft in pregnancy by inhibiting the cytotoxic functions of T and NK cells. The present study aimed to evaluate the impact of HLA-G rs1063320 (+3142G>C) and 14-bp insertion (ins)/deletion (del) polymorphisms on recurrent spontaneous abortion (RSA). Genomic DNA from 93 RSA patients and 93 normal fertile women was isolated using the salting out method. Genotyping of HLA-G +3142G>C and 14-bp ins/del variants was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFP) and PCR method, respectively. The HLA-G +3142G>C polymorphism increased the risk of RSA in codominant (OR = 2.39, 95%CI = 1.27-4.49, p = 0.010, GC vs GG; OR = 3.28, 95%CI = 1.16-9.72, p = 0.040, CC vs GG) and dominant (OR = 2.52, 95%CI = 1.37-4.64, p = 0.004, GC + CC vs GG) tested inheritance models. HLA-G rs1063320 C allele was associated with increased risk of RSA (OR = 1.84, 95%CI = 1.20-2.83, p = 0.007). The del/del genotype as well as del allele of 14-bp ins/del variant increased that risk of RSA (OR = 3.02, 95%CI = 1.23-7.41, p = 0.025 and OR = 1.65, 95%CI = 1.09-2.50, p = 0.022, respectively). In summary, our results showed that HLA-G gene polymorphisms significantly increased the risk of RSA in a sample of the Iranian population. Copyright © 2017. Published by Elsevier B.V.

The Frequency of c.550delA Mutation of the CANP3 Gene in the Polish LGMD2A Population.

PubMed

Dorobek, Małgorzata; Ryniewicz, Barbara; Kabzińska, Dagmara; Fidziańska, Anna; Styczyńska, Maria; Hausmanowa-Petrusewicz, Irena

2015-11-01

Limb girdle muscular dystrophy 2A (LGMD2A) is the most frequent LGMD variant in the European population, representing about 40% of LGMD. The c.550delA mutation in the CANP3 (calcium activated neutral protease 3) gene is the most commonly reported mutation in LGMD2A. Prevalence of this mutation in the Polish population has not been previously investigated. The aim of this study was to identify and estimate the frequency of the c.550delA mutation in Polish LGMD2A patients. Polymerase chain reaction-sequencing analysis, restriction fragment length polymorphism polymerase chain reaction method. We analyzed 76 families affected with LGMD and identified 62 probands with mutations in the CANP3 gene. C.550delA was the most common mutation identified, being found in 78% of the LGMD2A families. The remaining mutations observed multiple times were as follows: c.598-612del15ntd; c.2242C>T; c.418dupC; c.1356insT, listed in terms of decreasing frequency. Two novel variants in the CANP3 gene, that is, c.700G>A Gly234Arg and c.661G>A Gly221Ser were also characterized. Overall, mutations in the LGMD2A gene were estimated to be present in 81% of patients with the LGMD phenotype who were without sarcoglycans and dysferlin deficiency on immunocytochemical analysis. The frequency of the heterozygous c.550delA mutation in the healthy Polish population was estimated at 1/124. The c.550delA is the most frequent CANP3 mutation in the Polish population, thus sequencing of exon 4 of this gene could identify the majority of LGMD2A patients in Poland.

Experience the magic of light and color: outreach activity by Universidad del Valle student chapter

NASA Astrophysics Data System (ADS)

Valdes, Claudia; Reyes, Camilo; Osorio, Alberto; Solarte, Efrain

2010-08-01

During 2007, the Universidad del Valle Student Chapter presented a proposal for developing an educational outreach activity for children from an underprivileged zone to the Optical Society of America Foundation (OSAF) and to SPIE. The activity was carried out jointly by OSA and SPIE Universidad del Valle Student Chapters in the hillsides of Santiago de Cali, in a zone known as "Pueblo Joven" during 2008. It was aimed to boys and girls with ages between 8 and 13 years and was called "Experience the magic of light and color". The main purpose was to bring the children some basic concepts on optics and to encourage them to explore science through optics. The Universidad del Valle Student Chapters designed a series of talks and practical workshops where children participated in hands-on experiments that easily explain the fundamental concepts of light phenomena. Afterwards the children presented their achievements in a small science fair offered to the community and tried to explain in their own words what they learned and built. In this work, we present the most successful experimental designs and the educational standards we tried to develop with this activity.

Characteristics of the Earth's orbit by observations of the setting Sun

NASA Astrophysics Data System (ADS)

Sclar, N.

2000-07-01

Measurements of the setting Sun were carried out over a period of 16 months at Aliso Pier in Laguna Beach, CA, USA. The measurements are treated with simple analyses to provide good estimates of the obliquity of the ecliptic, and the eccentricity, velocities and radii of the Earth's elliptical orbit about the Sun.

27 CFR 9.54 - Santa Ynez Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of the La Laguna and Sisquoc Land Grants with the Los Padres National Forest. (10) Then following the boundary of the Los Padres National Forest south, east, and south until it intersects with the eastern... Los Padres National Forest. (13) Then south and west following the boundary of the Los Padres National...

Rethinking stratigraphy and site formation of the Pleistocene deposit at Cueva Negra del Estrecho del Río Quípar (Caravaca de la Cruz, Spain)

NASA Astrophysics Data System (ADS)

Angelucci, Diego E.; Anesin, Daniela; López Martínez, Mariano; Haber Uriarte, María; Rodríguez Estrella, Tomás; Walker, Michael J.

2013-11-01

Cueva Negra del Estrecho del Río Quípar (Caravaca de la Cruz, Murcia, Spain), hereinafter Cueva Negra, is a key-site for understanding the early peopling of Europe. Since 1990, systematic excavation has revealed an intriguing assemblage of lithic and faunal remains, and hominin teeth. It was deposited 0.99-0.78 Ma according to palaeomagnetic and biostratigraphical data; pollen data indicate warm moist conditions. Recently, possible evidence of thermal alteration was detected in a deep part of the deposit. We report here on our revision of the Cueva Negra stratigraphy, and offer information on site formation processes, based on new field observations and preliminary data from soil micromorphology. The Cueva Negra succession comprises three main stratigraphical complexes. Complex 1 is late Holocene. Complexes 2 and 3 are Pleistocene and are formed mainly of alluvial sediment, with subordinate inputs from the cave walls. Complexes 2 and 3 were accumulated almost without interruption, being separated by an erosive surface truncating a thin alluvial soil developed at the top of Complex 3. Our initial micromorphological findings indicate that anthropic inputs are mostly in derived positions, very likely having undergone inward displacement from the mouth of the rock-shelter.

The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population.

PubMed

Marouf, Chaymaa; Hajji, Omar; Diakité, Brehima; Tazzite, Amal; Jouhadi, Hassan; Benider, Abdellatif; Nadifi, Sellama

2015-01-01

The cell-cycle checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects has been associated with increased risk for breast cancer. The CHEK2 1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations. The highest frequency has been described in Northern and Eastern European countries. However, the 1100delC mutation has been investigated in different case-control studies and none in Moroccan population. The aim of this study was to evaluate the prevalence of this variant and determine its contribution to the development of breast cancer in sporadic cases and also in members of breast cancer families who tested negative or positive for a deleterious mutation in BRCA1/BRCA2. In this case-control study we performed the CHEK2 1100delC mutation analysis by ASO-PCR in 134 breast cancer patients and 114 unaffected control individuals. Most of these families had several cases of breast cancer or ovarian cancer (or both). No CHEK2 1100delC mutations were detected in any of 134 individuals, including 59 women diagnosed with breast cancer at an early age (<40 years), 10 women with bilateral breast cancer, and 6 women with ovarian cancer. Our preliminary genetic analysis are consistent with the reported very low frequency of CHEK2 1100delC mutation in North American populations (compared with Northern Europe), rendering CHEK2 1100delC such as an unlikely to be major breast cancer susceptibility genes.

Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).

ERIC Educational Resources Information Center

Eduplan Informa, 1971

1971-01-01

This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

"Gioco del Mondo" an Alpine Hopscotch Game and Prehistoric Cosmology. (Italian Title: Il "Gioco del Mondo" e il cosmo preistorico)

NASA Astrophysics Data System (ADS)

Ragazzi, G.

2015-04-01

"Gioco del Mondo" ("Hopscotch game" in Anglo-Saxon countries), is a children's game in which the memory of a knowledge belonging to the prehistory of western thought is preserved. The path of the game is an image of the cosmos. The jumps allow the player to move from one region to another in the cosmos, in order to retrieve the pebble, wich is interpreted as a symbol of the human soul. The game is the imitation of a healing ritual in which a shaman brings back the soul kidnapped by a spirit from in his headquarters in a region of the cosmos.

Photography and Neobaroque Imaginary in Julio Cortázar's "Las babas del diablo": Can the Neobaroque Name a Photograph?

ERIC Educational Resources Information Center

Hakobyan, Liana

2018-01-01

This article examines Julio Cortázar's short story "Las babas del diablo" from a visual perspective and at the intersection of Roland Barthes's ideas on photography and Severo Sarduy's theory on the Neobaroque. I propose that in "Las babas del diablo" photography and the Neobaroque--two seemingly unrelated concepts--interact…

78 FR 52716 - Proposed Amendment of Class E Airspace; Del Rio, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

..., Del Rio, TX. An additional segment to the north is needed to contain approach category E military aircraft conducting circling approaches to the airport, to retain the safety and management of IFR aircraft... to enhance the safety and management of Instrument Flight Rules (IFR) operations for instrument...

Determining sex and life stage of Del Norte salamanders from external cues

Treesearch

Lisa Ollivier; Hartwell H. Welsh Jr

2003-01-01

Life stage determination for many western plethodontids often requires dissection of the specimen. Availability of reliable external measures that could be applied under field conditions would enhance future studies of the genus Plethodon. We examined preserved specimens of the Del Norte Salamander, Plethodon elongatus, taken from...

Aplicación del Teorema de Nekhorochev para tiempos de estabilidad en Mecánica Celeste

NASA Astrophysics Data System (ADS)

Miloni, O.; Núñez, J.; Brunini, A.

En Mecánica Celeste, uno de los problemas centrales consiste en la determinación de los tiempos de estabilidad. El teorema de Nekhorochev proporciona un método para dicho estudio, para un sistema determinado por un hamiltoniano descripto en las variables acción-ángulo. El trabajo consiste en la acotación tanto del potencial perturbador y de la matriz hessiana del hamiltoniano integrable para determinar luego el tiempo de estabilidad de dicho sistema, donde por estabilidad se entiende la separación en norma infinito en el espacio de las acciones.

History and Use of del Nido Cardioplegia Solution at Boston Children’s Hospital

PubMed Central

Matte, Gregory S.; del Nido, Pedro J.

2012-01-01

Abstract: Cardioplegia is an integral and essential method of myocardial protection for patients of all ages requiring cardiac surgery in which the heart must be stopped. Numerous cardioplegia solutions and delivery methods have been developed. The del Nido cardioplegia solution has been in use for 18 years at Boston Children’s Hospital. This is a unique four parts crystalloid to one part whole blood formulation that is generally used in a single-dose fashion. Although the formulation was originally developed for use in pediatric and infant patients, its use for adult cardiac surgery has been expanding. National and international inquiries to our institution regarding this cardioplegia have been increasing over the last 2 years. We present the developmental history, supporting theory, and current protocol for use of what is now referred to as del Nido cardioplegia. PMID:23198389

Estudio del comportamiento tribologico y de las interacciones de superficie de nuevos nanofluidos ionicos

NASA Astrophysics Data System (ADS)

Espinosa Rodriguez, Tulia

tribocorrosion processes. The formation of a coating layer on magnesium alloys from phosphonate imidazolium ionic liquids by immersion and by chronoamperometry has been described. The new coatings reduce the abrasive wear in the magnesium-aluminium alloy but they are not effective in the magnesium-zinc alloy, which prevent the formation of continuous coatings. Los liquidos ionicos son sales liquidas a temperatura ambiente o bajas temperaturas que presentan excelentes propiedades fisico-quimicas. En el presente trabajo se estudian como lubricantes en problemas tribologicos complejos como la lubricacion de metales contra si mismos, el desarrollo de lubricantes base agua y de nuevas superficies autolubricadas. Cuando no es posible reducir la friccion y desgaste mediante lubricacion, como en las aleaciones de magnesio, los liquidos ionicos se han estudiado como precursores de recubrimientos protectores. Se han determinado las interacciones superficiales y los procesos de corrosion sobre cobre y sobre acero con diferentes liquidos ionicos proticos y aproticos para desarrollar nuevos lubricantes y aditivos. En el contacto cobre/cobre, excepto el liquido ionico protico derivado del oleato, todos los liquidos ionicos estudiados presentan mejor comportamiento tribologico que el lubricante comercial Polialfaolefina 6. En el contacto acero/zafiro, los nuevos liquidos ionicos proticos son buenos lubricantes cuando se utilizan en estado puro, y, como aditivos en agua, generan peliculas adsorbidas sobre la superficie del metal reduciendo la friccion y el desgaste tras la evaporacion del agua. Para evitar el periodo de alta friccion inicial en presencia de agua, se han generado peliculas superficiales de liquido ionico sobre el acero en condiciones estaticas. El mejor comportamiento lubricante tanto en el contacto cobre/cobre como en el contacto acero/zafiro se obtiene para el liquido ionico protico derivado del anion adipato, con dos grupos carboxilicos. Las interacciones de los grupos

The Role of mDia1 in the Aberrant Innate Immune Signaling in del(5q) Myelodysplastic Syndromes

DTIC Science & Technology

2017-10-01

especially in cells with sensitized innate immune signaling8,9,20. To analyze whether treatment of DAMPs could induce the over-production of pro...AWARD NUMBER: W81XWH-15-1-0335 TITLE: The Role of mDia1 in the Aberrant Innate Immune Signaling in del(5q) Myelodysplastic Syndromes...TITLE AND SUBTITLE 5a. CONTRACT NUMBER WThe Role of mDia1 in the Aberrant Innate Immune Signaling in del(5q) Myelodysplastic Syndromes 5b. GRANT

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS

PubMed Central

Schneider, Rebekka K.; Ademà, Vera; Heckl, Dirk; Järås, Marcus; Mallo, Mar; Lord, Allegra M.; Chu, Lisa P.; McConkey, Marie E.; Kramann, Rafael; Mullally, Ann; Bejar, Rafael; Solé, Francesc; Ebert, Benjamin L.

2014-01-01

Summary The Casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage whereas homozygous deletion induces hematopoietic stem cell failure. Based on this finding, we found that heterozygous inactivation of Csnk1a1 sensitizes cells to a CSNK1 inhibitor relative to cells with two intact alleles. In addition, we identified recurrent somatic mutations in CSNK1A1 on the non-deleted allele of patients with del(5q) MDS. These studies demonstrate that CSNK1A1 plays a central role in the biology of del(5q) MDS and is a promising therapeutic target. PMID:25242043

The c.301_302delAG PROP1 gene mutation in Romanian patients with multiple pituitary hormone deficiency.

PubMed

Lazea, Cecilia; Grigorescu-Sido, Paula; Popp, Radu; Legendre, Marie; Amselem, Serge; Al-Khzouz, Camelia; Bucerzan, Simona; Creţ, Victoria; Crişan, Mirela; Brad, Cristian

2015-09-01

To establish the frequency of the c.301_302 delAG mutation of the PROP1 gene in Romanian patients with multiple pituitary hormone deficiency (MPHD). Somatic assessment, hormonal test, bone age, magnetic resonance imaging of the pituitary gland, and molecular diagnosis were performed in 26 patients with MPHD (7 patients with familial form of MPHD and 19 patients with sporadic form of MPHD). The c.301_302delAG mutation was detected in the homozygous state in 10 patients belonging to 5 unrelated families (7 patients with familial history of MPHD and 3 patients with sporadic form of MPHD). Those 10 patients presented variable pituitary hormone deficiency and pituitary morphology. The c.301_302delAG homozygous genotype had a high frequency of 38% (10/26), reaching 100% (7/7) in group with familial cases of MPHD and 16% (3/19) in group with sporadic forms of MPHD.

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide

PubMed Central

2012-01-01

Background While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chromosomal abnormalities with new karyotyping tools may better predict response to LEN. Design and methods We have studied clinical, molecular and cytogenetic features of 42 patients with MDS, myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes and secondary acute myeloid leukemia (sAML) without del[5q] by metaphase cytogenetics (MC) who underwent therapy with LEN. Results Fluorescence in situ hybridization (FISH) or single nucleotide polymorphism array (SNP-A)-based karyotyping marginally increased the diagnostic yield over MC, detecting 2/42 (4.8%) additional cases with del[5q], one of whom were responded to LEN. Responses were more often observed in patients with a normal karyotype by MC (60% vs abnormal MC; 17%, p = .08) and those with gain of chromosome 8 material by either of all 3 karyotyping methods (83% vs all other chromosomal abnormalities; 44% p = .11). However, 5 out of those 6 patients received combined LEN/AZA therapy and it may also suggest those with gain of chromosome 8 material respond well to AZA. The addition of FISH or SNP-A did not improve the predictive value of normal cytogenetics by MC. Mutational analysis of TET2, UTX, CBL, EZH2, ASXL1, TP53, RAS, IDH1/2, and DNMT-3A was performed on 21 of 41 patients, and revealed 13 mutations in 11 patients, but did not show any molecular markers of responsiveness to LEN. Conclusions Normal karyotype and gain of chromosome 8 material was predictive of response to LEN in non-del[5q] patients with myeloid malignancies. PMID:22390313

DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA.

PubMed

Mondragón, Liliana; Monroy, Zuraya; Ito, Ma Emily; Medina-Mora, Dra Ma Elena

2010-06-01

El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio.La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos.Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos.

Occurrence and fate of linear and branched alkylbenzenesulfonates and their metabolites in surface waters in the Philippines.

PubMed

Eichhorn, P; Flavier, M E; Paje, M L; Kneppe, T P

2001-03-26

Laguna de Bay in the Philippines is one of the largest freshwater lakes in Asia and is considered a primary source of drinking water, but also receives daily discharges of effluent from both domestic and industrial activities. Branched alkylbenzenesulfonates (ABS), which were banned in Europe and withdrawn from the market in the U.S. since the mid-1960s, but not in Southeast Asia, and linear alkylbenzenesulfonates (LAS) are anionic surfactants used in detergent formulations and are therefore main components of effluent discharges. The presence of both LAS and ABS in several water streams in the catchment area of Laguna de Bay was determined using liquid chromatography-mass spectrometry (LC-MS). The concentration levels of LAS (1.2-73 and 2.2-102 microg l(-1)) and ABS (1.1-75 and 1-66 microg l(-1)) in some tributaries of Laguna de Bay and its outlet (Pasig River) to Manila Bay were assessed in December 1999 and March 2000, respectively. The LAS/ABS ratio was calculated as an indication of the extent of the distribution and fate of these surfactants in the surface water. The nearer the location to the metropolitan area of Manila, the higher the levels of LAS and ABS detected in the waters. Moreover, the extent of biodegradation was investigated by monitoring their alkyl homologue distribution and the presence of sulfophenylcarboxylate (SPC) metabolites. Similarly, differences in the levels of SPC and the homologues were apparent at the different sampling points. Presumably, even the quite recalcitrant ABS form SPCs under the conditions present in Southeast Asia. Since wastewater treatment facilities are not well established in developing countries like the Philippines, the call for the use of environmentally friendly chemicals is of even higher significance.

Conservation status of the buff-breasted sandpiper: Historic and contemporary distribution and abundance in south America

USGS Publications Warehouse

Lanctot, Richard B.; Blanco, D.E.; Dias, Rafael A.; Isacch, Juan P.; Gill, Verena A.; Almeida, Juliana B.; Delhey, Kaspar; Petracci, Pablo F.; Bencke, Glayson A.; Balbueno, Rodrigo A.

2002-01-01

We present historic and contemporary information on the distribution and abundance of Buff-breasted Sandpipers (Tryngites subruficollis) in South America. Historic information was collated from the literature, area ornithologists, and museums, whereas contemporary data were derived from surveys conducted throughout the main wintering range in Argentina, Uruguay, and Brazil during the austral summers of 1999 and 2001. Variable circular plot sampling was used to estimate population densities. During 1999, the highest concentration of Buff-breasted Sandpipers in Argentina was in southern Bahía Samborombón (General Lavalle District) and areas north of Mar Chiquita coastal lagoon. During 2001, the highest concentrations in Brazil were at Ilha da Torotama and Lagoa do Peixe National Park. During 1999 and 2001, the highest concentrations of Buff-breasted Sandpipers in Uruguay were found along three lagoons (Laguna de Rocha, Laguna de Castillos, and Laguna Garzón) bordering the Atlantic Ocean. Population densities (birds/ha) of Buff-breasted Sandpipers were 0.11 (95% C.I. = 0.04–0.31) in Argentina, 1.62 (0.67–3.93) in Brazil, and 1.08 (0.37–3.18) in Uruguay. High turnover rates at survey sites, due to the formation of large, mobile flocks, contributed to moderately large confidence intervals around our population density estimates. Nevertheless, compared with historic accounts of Buff-breasted Sandpipers, our survey data indicate the population size of this species has declined substantially since the late 1800s and contemporary information suggests the species has continued to decline during the past three decades. Buff-breasted Sandpipers were found almost exclusively in pasturelands and appear to depend heavily upon intensive grazing by livestock, which maintain suitable short grass conditions. We discuss the need for protection of critical areas and proper range management to ensure appropriate habitat remains available for the species, and provide suggestions

Applicability of transfer tensor method for open quantum system dynamics.

PubMed

Gelzinis, Andrius; Rybakovas, Edvardas; Valkunas, Leonas

2017-12-21

Accurate simulations of open quantum system dynamics is a long standing issue in the field of chemical physics. Exact methods exist, but are costly, while perturbative methods are limited in their applicability. Recently a new black-box type method, called transfer tensor method (TTM), was proposed [J. Cerrillo and J. Cao, Phys. Rev. Lett. 112, 110401 (2014)]. It allows one to accurately simulate long time dynamics with a numerical cost of solving a time-convolution master equation, provided many initial system evolution trajectories are obtained from some exact method beforehand. The possible time-savings thus strongly depend on the ratio of total versus initial evolution lengths. In this work, we investigate the parameter regimes where an application of TTM would be most beneficial in terms of computational time. We identify several promising parameter regimes. Although some of them correspond to cases when perturbative theories could be expected to perform well, we find that the accuracy of such approaches depends on system parameters in a more complex way than it is commonly thought. We propose that the TTM should be applied whenever system evolution is expected to be long and accuracy of perturbative methods cannot be ensured or in cases when the system under consideration does not correspond to any single perturbative regime.

Draft Genome Sequence of the Polyextremophilic Halorubrum sp. Strain AJ67, Isolated from Hyperarsenic Lakes in the Argentinian Puna.

PubMed

Burguener, Germán F; Maldonado, Marcos J; Revale, Santiago; Fernández Do Porto, Darío; Rascován, Nicolás; Vázquez, Martín; Farías, María Eugenia; Marti, Marcelo A; Turjanski, Adrián Gustavo

2014-02-06

Halorubrum sp. strain AJ67, an extreme halophilic UV-resistant archaeon, was isolated from Laguna Antofalla in the Argentinian Puna. The draft genome sequence suggests the presence of potent enzyme candidates that are essential for survival under multiple environmental extreme conditions, such as high UV radiation, elevated salinity, and the presence of critical arsenic concentrations.

Evaluación de la utilidad diagnóstica de la versión española del cuestionario al informador «AD8»☆

PubMed Central

Pardo, C. Carnero; de la Vega Cotarelo, R.; Alcalde, S. López; Aparicio, C. Martos; Carrillo, R. Vílchez; Gavilán, E. Mora; Galvin, J.E.

2012-01-01

Introducción El AD8 es un cuestionario al informador breve que puede ser autoaplicado y facilita la identificación de deterioro cognitivo (DC); nuestro objetivo es evaluar la utilidad diagnóstica (UD) de una versión española. Material y métodos Estudio transversal en una muestra clínica de díadas paciente/ informador, 330 sujetos con sospecha de DC o demencia (DEM) y 71 controles. Se ha evaluado la consistencia interna (α de Cronbach) y la validez (correlaciones parciales con estadio GDS, Fototest e índice funcional [IF]). La UD se ha evaluado para no DC vs DC (GDS 3–4) por medio del área bajo la curva ROC (aROC) y se ha considerado mejor punto de corte aquel que hacía máximo el índice de Youden. Resultados En la muestra, 105 no tenían DC, 99 tenían DC sin DEM y 203 DEM. La consistencia interna es alta (α 0,90, IC del 95%, 0,89–0,92), al igual que las correlaciones con GDS (r = 0,72, p < 0,001), Fototest (r = −0,61, p < 0,001) e IF (r = 0,59, p < 0,001). El aROC del AD8 es 0,90 (IC del 95%, 0,86–0,93), sin diferencia significativa con la del Fototest (aROC 0,93, IC del 95%, 0,89–0,96); el mejor punto de corte es 3/4 con sensibilidad de 0,93 (IC del 95%, 0,88–0,96), especificidad de 0,81 (IC del 95%, 0,72–0,88) y el 88,8% de las clasificaciones correctas. El uso conjunto de AD8 y Fototest mejora de forma significativa la UD de ambos (aROC 0,96, IC del 95%, 0,93–0,98, p < 0,05). Conclusiones La versión española del AD8 conserva las cualidades psicométricas y la UD de la versión original; su uso combinado con el Fototest mejora de forma significativa la UD de ambos. PMID:22652137

The Torres del Paine intrusion as a model for a shallow magma chamber

NASA Astrophysics Data System (ADS)

Baumgartner, Lukas; Bodner, Robert; Leuthold, Julien; Muntener, Othmar; Putlitz, Benita; Vennemann, Torsten

2014-05-01

The shallow magmatic Torres del Paine Intrusive Complex (TPIC) belongs to a series of sub-volcanic and plutonic igneous bodies in Southern Chile and Argentina. This trench-parallel belt is located in a transitional position between the Patagonia Batholith in the West, and the alkaline Cenozoic plateau lavas in the East. While volumetrically small amounts of magmatism started around 28 my ago in the Torres del Paine area, and a second period occurred between 17-16 Ma, it peaked with the TPIC 12.59-12.43 Ma ago. The spectacular cliffs of the Torres del Paine National park provide a unique opportunity to study the evolution of a very shallow magma chamber and the interaction with its host rocks. Intrusion depth can be estimated based on contact metamorphic assemblages and granite solidus thermobarometry to 750±250 bars, corresponding to an intrusion depth of ca. 3km, ca. 500m above the base of the intrusion. Hornblende thermobarometry in mafic rocks agrees well with these estimates (Leuthold et al., 2014). The TPIC is composed of a granitic laccolith emplaced over 90ka (Michel et al., 2008) in 3 major, several 100m thick sheets, forming an overall thickness of nearly 2 km. Contacts are sharp between sheets, with the oldest sheet on the top and the youngest on the bottom (Michel et al., 2008). The granitic laccolith is under-plated by a ca. 400m thick mafic laccolith, built up over ca. 50ka (Leuthold et al. 2012), constructed from the bottom up. Granitic and mafic sheets are themselves composed of multiple metric to decametric pulses, mostly with ductile contacts between them, resulting in outcrop patterns resembling braided stream sediments. The contact of the TPIC with the Cretaceous flysch sediments document intrusion mechanism. Pre-existing sub-horizontal fold axes are rotated in the roof of the TPIC, clearly demonstrating ballooning of the roof; no ballooning was observed in the footwall of the intrusion. Extension during ballooning of the roof is indicated by

The acoustic repertoire of bottlenose dolphins (Tursiops truncatus) from the southern Gulf of Mexico

NASA Astrophysics Data System (ADS)

Bazua-Duran, Carmen

2005-04-01

Bottlenose dolphins live in a variety of habitats of the world's oceans using their acoustic repertoire to communicate and inspect their environment. This work investigates the acoustic repertoire of bottlenose dolphins that inhabit a coastal lagoon of the southern Gulf of Mexico, the Laguna de Terminos and how it may relate to the dolphins' general behavioral state and herd size, and to the general characteristics of the habitat, such as visibility, depth, and sea state. Preliminary results show that bottlenose dolphins produce by far more clicks than whistles in all behavioral states (feeding, resting, social, and travel) and herd sizes, which may correlate with the decreased visibility and shallow depth of the Laguna de Terminos. Additionally, silence was found during all behavioral states, but very seldom in herds of large size. These preliminary results suggest that bottlenose dolphins are choosing when and where to produce their phonations. Therefore, more detailed studies are needed to understand how these animals are using their acoustic sense to communicate and inspect their environment. [Work supported by CONACyT-Gobierno Edo. de Campeche and PAPIIT, UNAM.

First report of linear megaplasmids in the genus Micrococcus.

PubMed

Dib, Julian R; Wagenknecht, Martin; Hill, Russell T; Farías, María E; Meinhardt, Friedhelm

2010-01-01

High-altitude wetlands (above 4200m) in the northwest of Argentina are considered pristine and extreme environments. Micrococcus sp. A1, H5, and V7, isolated from such environments, were shown to contain linear megaplasmids, designated pLMA1, pLMH5, and pLMV7, respectively. As known from linear plasmids of other actinomycetes, all three plasmids were resistant to lambda exonuclease treatment, which is consistent with having terminal proteins covalently attached to their 5' DNA ends. Electrophoretic mobility, Southern analysis, and restriction endonuclease patterns revealed pLMA1 and pLMH5 being indistinguishable plasmids, even though they were found in different strains isolated from two distant wetlands - Laguna Azul and Laguna Huaca Huasi. Analysis of 16S rDNA sequences of Micrococcus sp. A1, H5, and V7 suggested a close relationship to Micrococcus luteus. Typing of isolates was performed using fingerprint patterns generated by BOX-PCR. Plasmid-deficient strains, generated from Micrococcus sp. A1, showed a significantly decreased resistance level for erythromycin. Copyright 2009 Elsevier Inc. All rights reserved.

Aquifer-storage change in the lower Canada del Oro Subbasin, Pima County, Arizona, 1996-98

USGS Publications Warehouse

Pool, D.R.

1999-01-01

Aquifer storage was monitored using gravity methods in the Lower Canada del Oro subbasin from 1996 through 1998 to determine areas of infiltration and amounts of recharge along the Canada del Oro Wash after major surface flow and to estimate aquifer-storage change and specific-yield values for the regional aquifer.  Both purposes were addressed by periodic monitoring of changes in aquifer storage and water levels at a network of gravity stations and monitor wells.  Water levels and gravity were also monitored near an active withdrawal well for several months for the purpose of estimating specific yield of the aquifer within the cone of water-leel depression at the well.

PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

PubMed

Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

2010-12-01

A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH.

El contexto de la familia y el vecindario en la salud de los ancianos del estudio EPESE hispano

PubMed Central

Reyes-Ortiz, Carlos A.; Camacho, María E.; Eschbach, Karl; Markides, Kyriakos S.

2014-01-01

RESUMEN En este artículo se discute el papel de la familia y el vecindario en la salud de los ancianos méjico-americanos del estudio EPESE (Established Populations for Epidemiologic Studies of the Elderly) hispano. La paradoja epidemiológica consiste en que, a pesar de estar en desventaja socioeconómica, los ancianos hispanos tienen mortalidad relativamente menor que los ancianos de raza blanca. Esto es especialmente cierto cuando el anciano vive en los vecindarios donde hay un porcentaje alto de méjico-americanos. La familia también juega un papel importante en estos ancianos al disminuir el riesgo de institucionalización o de morbilidad. Asimismo, el estrés originado en problemas económicos o al depender económicamente de la familia, habiendo inmigrado en edades tardías, puede sobrepasar la capacidad de amortiguamiento del estrés y afectar la salud del anciano méjico-americano. PMID:25190897

Study of InDel genetic markers with forensic and ancestry informative interest in PALOP's immigrant populations in Lisboa.

PubMed

Inácio, Ana; Costa, Heloísa Afonso; da Silva, Cláudia Vieira; Ribeiro, Teresa; Porto, Maria João; Santos, Jorge Costa; Igrejas, Gilberto; Amorim, António

2017-05-01

The migratory phenomenon in Portugal has become one of the main factors for the genetic variability. In the last few years, a new class of autosomal insertion/deletion markers-InDel-has attracted interest in forensic genetics. Since there is no data for InDel markers of Portuguese-speaking African countries (PALOP) immigrants living in Lisboa, our aim is the characterization of those groups of individuals by typing them with at least 30 InDel markers and to compare different groups of individuals/populations. We studied 454 bloodstain samples belonging to immigrant individuals from Angola, Guinea-Bissau, and Mozambique. DNA extraction was performed with the Chelex® 100 method. After extraction, all samples were typed with the Investigator® DIPplex method. Through the obtained results, allelic frequencies show that all markers are at Hardy-Weinberg equilibrium, and we can confirm that those populations show significant genetic distances between themselves, between them, and the host Lisboa population. Because of this, they introduce genetic variability in Lisboa population.

Population Differentiations and Phylogenetic Analysis of Tibet and Qinghai Tibetan Groups Based on 30 InDel Loci.

PubMed

Guo, Yuxin; Shen, Chunmei; Meng, Haotian; Dong, Qian; Kong, Tingting; Yang, Chunhua; Wang, Hongdan; Jin, Rui; Zhu, Bofeng

2016-12-01

In recent years, Insertion/Deletion (InDel) polymorphisms have become a hot area of forensic research. In this study, 30 InDel loci were selected to investigate the genetic polymorphisms of Tibetan groups, which are from Tibet Autonomous Region and Qinghai province of China, and explore the genetic relationships between Tibetan groups and other groups. Allele frequencies of the 30 InDel loci ranged from 0.1219 (HLD111) to 0.5609 (HLD57) in the Tibet Tibetan group and 0.1639 (HLD118) to 0.5655 (HLD124) in the Qinghai Tibetan group. The combined power of discrimination, matching probability, and power of exclusion were 0.999999999986, 0.999999988, and 0.9913 in the Tibet Tibetan group, respectively, and 0.99999999999204, 0.9999999796, and 0.9862 in the Qinghai Tibetan group. The results of principal component analysis, phylogenetic tree, and population structure demonstrated that the four Tibetan groups (Tibetan1, Tibetan2, Tibet, and Qinghai Tibetan groups) clustered together and had relatively close genetic relationships with nine Asian groups and then European and Amerindian groups.

Draft Genome Sequence of the Polyextremophilic Exiguobacterium sp. Strain S17, Isolated from Hyperarsenic Lakes in the Argentinian Puna.

PubMed

Ordoñez, Omar F; Lanzarotti, Esteban; Kurth, Daniel; Gorriti, Marta F; Revale, Santiago; Cortez, Néstor; Vazquez, Martin P; Farías, María E; Turjanski, Adrian G

2013-07-25

Exiguobacterium sp. strain S17 is a moderately halotolerant, arsenic-resistant bacterium that was isolated from Laguna Socompa stromatolites in the Argentinian Puna. The draft genome sequence suggests potent enzyme candidates that are essential for survival under multiple environmental extreme conditions, such as high levels of UV radiation, elevated salinity, and the presence of critical arsenic concentrations.

Sports Drove Silva to Teach Wellness

ERIC Educational Resources Information Center

Deschenie, Tina

2008-01-01

This article profiles teacher Leroy Silva (Laguna), 27, a.k.a. "Buster". Silva describes himself as an active guy who stays busy working out, playing basketball, softball, and more recently golf, soccer, and lacrosse. He teaches personal wellness and sports (not physical education), a job he began in 2006. Before that he was a trainer at…

Education for Rural Development: The Case of the UPCA/BNE Barrio Development School Project.

ERIC Educational Resources Information Center

Contado, Tito E.

The Barrio Development School, a 4-year action-research project which has been in operation for 2 years, is located at Masaya, Bay, Laguna, Philippines. Begun by the University of the Philippines, College of Agriculture, and the Board of National Education, it is a secondary school program for barrio youths who have decided to stay, live, and work…

A Multi-Scale Approach to Assess and Restore Ecosystems in a Watershed Context

DTIC Science & Technology

2013-09-01

Laguna Formation .. Mehrten Formation .. Metamorphic Rocks , Undifferentiated .. Modesto Formation. Upper Unit c=J North Merced Gravel .. Riverbank...distribution is unlimited. The US Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental...watershed assessment procedure that can be used to evaluate existing ecological conditions as well as proposed changes. The approach employs indicators

Draft Genome Sequence of the Polyextremophilic Halorubrum sp. Strain AJ67, Isolated from Hyperarsenic Lakes in the Argentinian Puna

PubMed Central

Burguener, Germán F.; Maldonado, Marcos J.; Revale, Santiago; Fernández Do Porto, Darío; Rascován, Nicolás; Vázquez, Martín; Farías, María Eugenia; Marti, Marcelo A.

2014-01-01

Halorubrum sp. strain AJ67, an extreme halophilic UV-resistant archaeon, was isolated from Laguna Antofalla in the Argentinian Puna. The draft genome sequence suggests the presence of potent enzyme candidates that are essential for survival under multiple environmental extreme conditions, such as high UV radiation, elevated salinity, and the presence of critical arsenic concentrations. PMID:24503991

Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657del5, in three Slav populations.

PubMed

Varon, R; Seemanova, E; Chrzanowska, K; Hnateyko, O; Piekutowska-Abramczuk, D; Krajewska-Walasek, M; Sykut-Cegielska, J; Sperling, K; Reis, A

2000-11-01

Nijmegen breakage syndrome (NBS) is a chromosomal instability disorder, clinically characterised by microcephaly, immunodeficiency, radiosensitivity and a very high predisposition to lymphoid malignancy. Recently, it was demonstrated that mutations in the NBS1 gene are responsible for NBS. Most of the NBS patients known so far are of Slav origin and carry a major founder mutation 657del5 in exon 6 of the NBS1 gene. In this study we estimated the prevalence of the 657del5 mutation in the Czech Republic, Poland and the Ukraine. We found an unexpectedly high carrier frequency of the 657del5 mutation (1/177) in the three Slav populations, a factor that may contribute to cancer frequency in those countries. In addition, we show that NBS patients are often diagnosed late and therefore receive inappropriate therapy.

Soilscapes in the dynamic tropical environments: The case of Sierra Madre del Sur

NASA Astrophysics Data System (ADS)

Krasilnikov, P. V.; García-Calderón, N. E.; Ibáñez-Huerta, A.; Bazán-Mateos, M.; Hernández-Santana, J. R.

2011-12-01

The paper gives an analysis of the pattern of soil cover of the Sierra Madre del Sur, one of the most complex physiographic regions of Mexico. It presents the results of the study of four latitudinal traverses across the region. We show that the distribution of soils in the Sierra Madre del Sur is associated with major climatic gradients, namely by vertical bioclimatic zonality in the mountains and by the effect of mountain shadow. Altitudinal distribution of soil-bioclimatic belts is complex due to non-uniform gradients of temperature and rainfall, and varies with the configuration of the mountain range. The distribution of soils is associated with the erosion and accumulation rates both on mountain slopes and in river valleys. The abundance of poorly developed soils in (semi)arid areas was ascribed to high erosion rate rather than to low pedogenetic potential. The formation of soil mosaic at a larger scale might be ascribed to the complex net of gully erosion and to the system of seismically triggered landslides of various ages. In the valleys, the distribution of soils depends upon the dynamics of sedimentation and erosion, which eventually exposes paleosols. Red-colored clayey sediments are remains of ancient weathering and pedogenesis. Their distribution is associated mainly with the intensity of recent slope processes. The soil cover pattern of the Sierra Madre del Sur cannot be explained by simplified schemes of bioclimatic zonality. The soil ranges can be explained by the distribution of climates, lithology, complex geological history of the region, and recent geomorphological processes.

Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California

USGS Publications Warehouse

Schiffman, P.; Williams, A.E.; Evarts, R.C.

1984-01-01

The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ??18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4??? (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ??18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500??C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center. ?? 1984.

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.

PubMed

Chao de la Barca, Juan Manuel; Simard, Gilles; Sarzi, Emmanuelle; Chaumette, Tanguy; Rousseau, Guillaume; Chupin, Stéphanie; Gadras, Cédric; Tessier, Lydie; Ferré, Marc; Chevrollier, Arnaud; Desquiret-Dumas, Valérie; Gueguen, Naïg; Leruez, Stéphanie; Verny, Christophe; Miléa, Dan; Bonneau, Dominique; Amati-Bonneau, Patrizia; Procaccio, Vincent; Hamel, Christian; Lenaers, Guy; Reynier, Pascal; Prunier-Mirebeau, Delphine

2017-02-01

Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood. Using a targeted metabolomic approach, we measured the concentrations of 188 metabolites in nine tissues, that is, brain, three types of skeletal muscle, heart, liver, retina, optic nerve, and plasma in symptomatic 11-month-old Opa1delTTAG/+ mice. Significant metabolic signatures were found only in the optic nerve and plasma of female mice. The optic nerve signature was characterized by altered concentrations of phospholipids, amino acids, acylcarnitines, and carnosine, whereas the plasma signature showed decreased concentrations of amino acids and sarcosine associated with increased concentrations of several phospholipids. In contrast, the investigation of 3-month-old presymptomatic Opa1delTTAG/+ mice showed no specific plasma signature but revealed a significant optic nerve signature in both sexes, although with a sex effect. The Opa1delTTAG/+ versus wild-type optic nerve signature was characterized by the decreased concentrations of 10 sphingomyelins and 10 lysophosphatidylcholines, suggestive of myelin sheath alteration, and by alteration in the concentrations of metabolites involved in neuroprotection, such as dimethylarginine, carnitine, spermine, spermidine, carnosine, and glutamate, suggesting a concomitant axonal metabolic dysfunction. Our comprehensive metabolomic investigations revealed in symptomatic as well as in presymptomatic Opa1delTTAG/+ mice, a specific sensitiveness of the optic nerve to Opa1 insufficiency, opening new routes for protective therapeutic strategies.

Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos

NASA Astrophysics Data System (ADS)

Cellone, S. A.

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Seven new species of Loneura Navás (Insecta: Psocodea: 'Psocoptera': Ptiloneuridae) from Valle del Cauca, Colombia.

PubMed

Nieto, Julián Alexander Mendivil; Aldrete, Alfonso Neri García; Obando, Ranulfo González

2017-02-06

Seven species of Loneura from natural areas of Valle del Cauca, Colombia, are described and illustrated. The female of L. andina is described for the first time. Two additional species, known only from the National Natural Park Gorgona (Cauca), are also recorded in Valle del Cauca. The new species are assigned to the infrageneric groups known in the genus. An identification key to males of Loneura is included.

Characterization of Rhodococcus sp. A5wh isolated from a high altitude Andean lake to unravel the survival strategy under lithium stress.

PubMed

Belfiore, Carolina; Curia, María V; Farías, María E

2017-11-24

Lithium (Li) is widely distributed in nature and has several industrial applications. The largest reserves of Li (over 85%) are in the so-called "triangle of lithium" that includes the Salar de Atacama in Chile, Salar de Uyuni in Bolivia and Salar del Hombre Muerto in Argentina. Recently, the use of microorganisms in metal recovery such as copper has increased; however, there is little information about the recovery of lithium. The strain Rhodococcus sp. A5 wh used in this work was previously isolated from Laguna Azul. The assays revealed that this strain was able to accumulate Li (39.52% of Li/g microbial cells in 180min) and that it was able to grow in its presence up to 1M. In order to understand the mechanisms implicated in Li tolerance, a proteomic approach was conducted. Comparative proteomic analyses of strain A5 wh exposed and unexposed to Li reveal that 17 spots were differentially expressed. The identification of proteins was performed by MALDI-TOF/MS, and the obtained results showed that proteins involved in stress response, transcription, translations, and metabolism were expressed under Li stress. This knowledge constitutes the first proteomic approach to elucidate the strategy followed by Rhodococcus to adapt to Li. Copyright © 2017 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA1

PubMed Central

Mondragón, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena

2010-01-01

El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

Spatial and temporal constraints on regional-scale groundwater flow in the Pampa del Tamarugal Basin, Atacama Desert, Chile

NASA Astrophysics Data System (ADS)

Jayne, Richard S.; Pollyea, Ryan M.; Dodd, Justin P.; Olson, Elizabeth J.; Swanson, Susan K.

2016-12-01

Aquifers within the Pampa del Tamarugal Basin (Atacama Desert, northern Chile) are the sole source of water for the coastal city of Iquique and the economically important mining industry. Despite this, the regional groundwater system remains poorly understood. Although it is widely accepted that aquifer recharge originates as precipitation in the Altiplano and Andean Cordillera to the east, there remains debate on whether recharge is driven primarily by near-surface groundwater flow in response to periodic flood events or by basal groundwater flux through deep-seated basin fractures. In addressing this debate, the present study quantifies spatial and temporal variability in regional-scale groundwater flow paths at 20.5°S latitude by combining a two-dimensional model of groundwater and heat flow with field observations and δ18O isotope values in surface water and groundwater. Results suggest that both previously proposed aquifer recharge mechanisms are likely influencing aquifers within the Pampa del Tamarugal Basin; however, each mechanism is operating on different spatial and temporal scales. Storm-driven flood events in the Altiplano readily transmit groundwater to the eastern Pampa del Tamarugal Basin through near-surface groundwater flow on short time scales, e.g., 100-101 years, but these effects are likely isolated to aquifers in the eastern third of the basin. In addition, this study illustrates a physical mechanism for groundwater originating in the eastern highlands to recharge aquifers and salars in the western Pampa del Tamarugal Basin over timescales of 104-105 years.

The p.Leu167del Mutation in APOE Gene Causes Autosomal Dominant Hypercholesterolemia by Down-regulation of LDL Receptor Expression in Hepatocytes.

PubMed

Cenarro, Ana; Etxebarria, Aitor; de Castro-Orós, Isabel; Stef, Marianne; Bea, Ana M; Palacios, Lourdes; Mateo-Gallego, Rocío; Benito-Vicente, Asier; Ostolaza, Helena; Tejedor, Teresa; Martín, César; Civeira, Fernando

2016-05-01

The p.Leu167del mutation in the APOE gene has been associated with hyperlipidemia. Our objective was to determine the frequency of p.Leu167del mutation in APOE gene in subjects with autosomal dominant hypercholesterolemia (ADH) in whom LDLR, APOB, and PCSK9 mutations had been excluded and to identify the mechanisms by which this mutant apo E causes hypercholesterolemia. The APOE gene was analyzed in a case-control study. The study was conducted at a University Hospital Lipid Clinic. Two groups (ADH, 288 patients; control, 220 normolipidemic subjects) were included. We performed sequencing of APOE gene and proteomic and cellular experiments. To determine the frequency of the p.Leu167del mutation and the mechanism by which it causes hypercholesterolemia. In the ADH group, nine subjects (3.1%) were carriers of the APOE c.500_502delTCC, p.Leu167del mutation, cosegregating with hypercholesterolemia in studied families. Proteomic quantification of wild-type and mutant apo E in very low-density lipoprotein (VLDL) from carrier subjects revealed that apo E3 is almost a 5-fold increase compared to mutant apo E. Cultured cell studies revealed that VLDL from mutation carriers had a significantly higher uptake by HepG2 and THP-1 cells compared to VLDL from subjects with E3/E3 or E2/E2 genotypes. Transcriptional down-regulation of LDLR was also confirmed. p.Leu167del mutation in APOE gene is the cause of hypercholesterolemia in the 3.1% of our ADH subjects without LDLR, APOB, and PCSK9 mutations. The mechanism by which this mutation is associated to ADH is that VLDL carrying the mutant apo E produces LDLR down-regulation, thereby raising plasma low-density lipoprotein cholesterol levels.

On the first occupational medicine initiatives in Mexico: The Real del Monte miners’ hospital.

PubMed

Gómez, José Luis; Rodríguez-Paz, Carlos Agustín

2018-01-01

Despite the legislation of Otto von Bismarck (1815-1898) on social security rights formulated in 1883 in Germany where it is stated that it is the duty of the State to promote the welfare of all members of society, particularly the weakest and most needy, using the means available to them, and the proposals of laws against accidents issued on April 30, 1904 in the State of Mexico in 1904, in the Mexico of the Porfirio Díaz era, providing workers with formal medical care was not contemplated, except in the case of some railway companies, hospitals for the care of patients with occupational diseases were not built. One of these exceptions was the Hospital del Mineral del Real del Monte de Pachuca, founded in the late nineteenth century and after the mining company passed to the Americans in 1906, it was agreed that the company acquired the hospital and equated it with the medical and surgical advances of the time for immediate care of injuries, especially of the orthopedic type, which enabled not only the healing of wounds, but also rehabilitation. This hospital is one of the oldest in Mexico with regard to three disciplines: orthopedics, occupational medicine and rehabilitation. It ceased to operate in 1982, and currently it is a museum with a rich collection of documents and instruments related to the aforementioned disciplines. Copyright: © 2018 SecretarÍa de Salud.

X-ray detection of Nova Del 2013 with Swift

NASA Astrophysics Data System (ADS)

Castro-Tirado, Alberto J.; Martin-Carrillo, Antonio; Hanlon, Lorraine

2013-08-01

Continuous X-ray monitoring by Swift of Nova Del 2013 (see CBET #3628) shows an increase of X-ray emission at the source location compared to previous observations (ATEL #5283, ATEL #5305) during a 3.9 ksec observation at UT 2013-08-22 12:05. With the XRT instrument operating in window timing mode, 744 counts were extracted from a 50 pixel long source region and 324 counts from a similar box for a background region, resulting in a 13-sigma detection with a net count rate of 0.11±0.008 counts/sec.

Evaporación dinámica del cinturón de asteroides original

NASA Astrophysics Data System (ADS)

Brunini, A.

Hemos integrado numéricamente un enjambre de 3000 partículas en la región del cinturón de asteroides, sujetas a las perturbaciones gravitatorias de Júpiter y Saturno. Al cabo de 107 años, se han formado ya todos los gaps de Kirkwood observados en el cinturón actual. El grupo en la resonancia 3/2 es, aunque en menor grado, también visible. Los tiempos de Lyapunov computados para los asteroides sobrevivientes, nos ha permitido encontrar la fracción de ellos que es capaz de sobrevivir por toda la edad del sistema solar, merced a la aplicacion de la relación empírica que vincula dichos tiempos al tiempo en el cual se manifiestan grandes transiciones orbitales. La fracción de supervivientes es de aproximadamente 1/100. El resto de la masa faltante en el cinturón, es atribuible a colisiones catastróficas con cometas en etapas primordiales.

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

Discovering research value in the Campo del Cielo, Argentina, meteorite craters

NASA Astrophysics Data System (ADS)

Cassidy, William A.; Renard, Marc L.

1996-07-01

The Campo del Cielo meteorite crater field in Argentina contains at least 20 small meteorite craters, but a recent review of the field data and a remote sensing study suggest that there may be more. The fall occurred ˜4000 years ago into a uniform loessy soil, and the craters are well enough preserved so that some of their parameters of impact can be determined after excavation. The craters were formed by multi-ton fragments of a type IA meteoroid with abundant silicate inclusions. Relative to the horizontal, the angle of infall was ˜9°. Reflecting the low angle of infall, the crater field is elongated with apparent dimensions of 3 × 18.5 km. The largest craters are near the center of this ellipse. This suggests that when the parent meteoroid broke apart, the resulting fragments diverged from the original trajectory in inverse relation to their masses and did not undergo size sorting due to atmospheric deceleration. The major axis of the crater field as we know it extends along N63°E, but the azimuths of infall determined by excavation of Craters 9 and 10 are N83.5°E and N75.5°E, respectively. This suggests that the major axis of the crater field is not yet well determined. The three or four largest craters appear to have been formed by impacts that disrupted the projectiles, scattering fragments around the outsides of the craters and leaving no large masses within them; these are relatively symmetrical in shape. Other craters are elongated features with multi-ton masses preserved within them and no fragmentation products outside. There are two ways in which field research on the Campo del Cielo crater field is found to be useful. (1) Studies exist that have been used to interpret impact craters on planetary surfaces other than the Earth. This occurrence of a swarm of projectiles impacting at known angles and similar velocities into a uniform target material provides an excellent field site at which to test the applicability of those studies. (2) Individual

Desarrollo de un instrumento para medir percepciones sobre el contexto de construccion del conocimiento cientifico de estudiantes universitarios de nuevo ingreso

NASA Astrophysics Data System (ADS)

Garcia-Ramirez, Jaime Antonio

En esta investigacion, se desarrollo un instrumento que permite medir percepciones relacionadas al contexto de constriccion del conocimiento cientifico. Se examinaron instrumentos existentes y se encontro que el VOSTS (Views on science, technology, and society), instrumento desarrollado empiricamente en Canada por Aikenhead, Ryan y Fleming, podia traducirse y validarse en el contexto cultural puertorriqueno. El instrumento es extenso, consta de 113 reactivos, cada uno con una premisa basica relacionada a la tematica ciencia, tecnologia y sociedad y un numero de alternativas relacionadas a la premisa que oscila entre siete y trece. Se delimito su utilizacion a los quince reactivos identificados por los autores como relacionados a la construccion social del conocimiento cientifico. Metodologicamente, se procedio a utilizar el modelo de adaptacion intercultural, que permite que el instrumento desarrollado satisfaga las dimensiones de equivalencia semantica, de contenido, tecnica, de criterio y conceptual, atemperado asi al instrumento original. Se cumplio con este proposito mediante la traduccion de la version original en ingles al espanol y viceversa. Se utilizaron comites para examinar la traduccion y la retro-traduccion del instrumento. Se realizo una prueba piloto con estudiantes universitarios de nuevo ingreso, utilizando el instrumento traducido para asegurar su intelegibilidad. La confiabilidad del instrumento se determino mediante la intervencion de un panel de expertos quienes clasificaron las distintas posiciones dentro de cada reactivo en: realista, con merito e ingenua; se transformaron estas opciones en valores numericos lo que permitio establecer una escala Likert para cada una. Se suministro el instrumento a una muestra de estudiantes universitarios de nuevo ingreso con caracteristicas similares a las de la poblacion puertorriquena en cuanto a ejecucion en las pruebas de aptitud verbal y matematica del College Board. Los resultados de sus contestaciones

Guía para la evaluación del riesgo de los polinizadores

EPA Pesticide Factsheets

La Guía para la evaluación del riesgo de los polinizadores de la EPA es parte de una estrategia de la evaluación de los riesgos que presentan los pesticidas para las abejas a fin de mejorar la protección de los polinizadores.

ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY

EPA Science Inventory

Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

Ozone studies in the Paso del Norte region

NASA Astrophysics Data System (ADS)

Becerra-Davila, Fernando

The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results

[Heterozygous carriers of Slavic mutation 657del5 of NBN gene in patients with colorectal cancer].

PubMed

Seemanová, Eva; Hoch, Jirí; Seeman, Pavel

2011-01-01

Nijmegen breakage syndrome (NBS) is one of the chromosomal instability syndromes due to DNA repair disorder. The syndrome is autosomal recessive determined, in homozygotes is characterized by many disorders including high predisposition to lymphoreticular malignancy in childhood and adolescence. Laboratory findings represent low level of immunoglobulins, B and T lymphocytes, increased sensitivity to the mutagens, especially hyperradiosensitivity and increased chromosomal instability. Heterozygotes show also elevated radiosensitivity and have an increased cancer risk in adult age. There is no predilection of the malignancy. Colorectal cancer was found often among the relatives of patients with NBS. Majority of the NBS patients are of the Central and Eastern European origin and carry the common founder mutation 657del5 in the NBN gene. The formation of second malignancy both in homozygotes and heterozygotes can be prevented by excluding any radiation. The aim of study is estimation of frequency of 657del5 heterozygotes among patients with colorectal cancer. Within a group of 161 patients with colorectal cancer 5 heterozygotes with 657del5 mutation were registered, e.g. 5-times higher incidence than expected. The elemental prevention in patients with proved positivity of Slavic mutation in NBN gene is to exclude any radiation.

Highly efficient and exact method for parallelization of grid-based algorithms and its implementation in DelPhi

PubMed Central

Li, Chuan; Li, Lin; Zhang, Jie; Alexov, Emil

2012-01-01

The Gauss-Seidel method is a standard iterative numerical method widely used to solve a system of equations and, in general, is more efficient comparing to other iterative methods, such as the Jacobi method. However, standard implementation of the Gauss-Seidel method restricts its utilization in parallel computing due to its requirement of using updated neighboring values (i.e., in current iteration) as soon as they are available. Here we report an efficient and exact (not requiring assumptions) method to parallelize iterations and to reduce the computational time as a linear/nearly linear function of the number of CPUs. In contrast to other existing solutions, our method does not require any assumptions and is equally applicable for solving linear and nonlinear equations. This approach is implemented in the DelPhi program, which is a finite difference Poisson-Boltzmann equation solver to model electrostatics in molecular biology. This development makes the iterative procedure on obtaining the electrostatic potential distribution in the parallelized DelPhi several folds faster than that in the serial code. Further we demonstrate the advantages of the new parallelized DelPhi by computing the electrostatic potential and the corresponding energies of large supramolecular structures. PMID:22674480

Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.

PubMed

Zhang, Shiyu; Phelan, Catherine M; Zhang, Phil; Rousseau, Francois; Ghadirian, Parviz; Robidoux, Andre; Foulkes, William; Hamel, Nancy; McCready, David; Trudeau, Maureen; Lynch, Henry; Horsman, Douglas; De Matsuda, Maria Lourdes Leon; Aziz, Zeba; Gomes, Magda; Costa, Mauricio Magalhaes; Liede, Alexander; Poll, Aletta; Sun, Ping; Narod, Steven A

2008-04-01

A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranean. The frequency of the 1100delC allele has not been measured in non-White populations. We measured the frequency of the CHEK2 founder allele in 3,882 breast cancer patients and 8,609 controls from various countries. The allele was not seen among Asian patients (from Pakistan or the Philippines) and was present in 1 of 155 cases from Brazil. Among White women, the allele was present in 1.5% of 825 familial cases of breast cancer and in 0.7% of 1,106 patients with nonfamilial breast cancer. The allele was equally frequent in Jewish and non-Jewish patients. We estimate that the CHEK2 1100delC allele is associated with an odds ratio of 2.6 for breast cancer, which corresponds to a lifetime risk of approximately 24% in Ontario.

En cumplimiento con la orden ejecutiva del presidente Trump sobre la Independencia Energética

EPA Pesticide Factsheets

Acciones reglamentarias tomadas por la EPA, incluyendo audiencias públicas, para implementar la Orden Ejecutiva sobre la Independencia Energética y la propuesta derogación del Plan de Energía Limpia.

Application of the Angular Overlap Model to Lanthanide Phthalocyanines (Aplicacion Del Modelo de Traslape Angular a Ftalocinaninas de Lantanidos)

DTIC Science & Technology

1989-07-15

metilicos. Esto trae a la teoria del campo ligante el concepto de grupos funcionales. En este trabajo se us6 el enfoque del MTA desarrollado por...susceptibilidades magne’ticas se hizo de acuerdo a la teoria de perturbaciones usando la ecuacio’n de Van Vleckc. Es importante recordar que a pesar de...en el anillo pirrolico la deslocalizacio’n en el grupo imina es peque? a, y el sistema no se altera mucho debido a la donaci6n W. A partir de lus

Impact of the F508del mutation on ovine CFTR, a Cl− channel with enhanced conductance and ATP-dependent gating

PubMed Central

Cai, Zhiwei; Palmai-Pallag, Timea; Khuituan, Pissared; Mutolo, Michael J; Boinot, Clément; Liu, Beihui; Scott-Ward, Toby S; Callebaut, Isabelle; Harris, Ann; Sheppard, David N

2015-01-01

Cross-species comparative studies are a powerful approach to understanding the epithelial Cl− channel cystic fibrosis transmembrane conductance regulator (CFTR), which is defective in the genetic disease cystic fibrosis (CF). Here, we investigate the single-channel behaviour of ovine CFTR and the impact of the most common CF mutation, F508del-CFTR, using excised inside-out membrane patches from transiently transfected CHO cells. Like human CFTR, ovine CFTR formed a weakly inwardly rectifying Cl− channel regulated by PKA-dependent phosphorylation, inhibited by the open-channel blocker glibenclamide. However, for three reasons, ovine CFTR was noticeably more active than human CFTR. First, single-channel conductance was increased. Second, open probability was augmented because the frequency and duration of channel openings were increased. Third, with enhanced affinity and efficacy, ATP more strongly stimulated ovine CFTR channel gating. Consistent with these data, the CFTR modulator phloxine B failed to potentiate ovine CFTR Cl− currents. Similar to its impact on human CFTR, the F508del mutation caused a temperature-sensitive folding defect, which disrupted ovine CFTR protein processing and reduced membrane stability. However, the F508del mutation had reduced impact on ovine CFTR channel gating in contrast to its marked effects on human CFTR. We conclude that ovine CFTR forms a regulated Cl− channel with enhanced conductance and ATP-dependent channel gating. This phylogenetic analysis of CFTR structure and function demonstrates that subtle changes in structure have pronounced effects on channel function and the consequences of the CF mutation F508del. Key points Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a gated pathway for chloride movement, causes the common life-shortening genetic disease cystic fibrosis (CF). Towards the development of a sheep model of CF, we have investigated the function of sheep CFTR. We found that

The USH2A c.2299delG mutation: dating its common origin in a Southern European population

PubMed Central

Aller, Elena; Larrieu, Lise; Jaijo, Teresa; Baux, David; Espinós, Carmen; González-Candelas, Fernando; Nájera, Carmen; Palau, Francesc; Claustres, Mireille; Roux, Anne-Françoise; Millán, José M

2010-01-01

Usher syndrome type II is the most common form of Usher syndrome. USH2A is the main responsible gene of the three known to be disease causing. It encodes two isoforms of the protein usherin. This protein is part of an interactome that has an essential role in the development and function of inner ear hair cells and photoreceptors. The gene contains 72 exons spanning over a region of 800 kb. Although numerous mutations have been described, the c.2299delG mutation is the most prevalent in several populations. Its ancestral origin was previously suggested after the identification of a common core haplotype restricted to 250 kb in the 5′ region that encodes the short usherin isoform. By extending the haplotype analysis over the 800 kb region of the USH2A gene with a total of 14 intragenic single nucleotide polymorphisms, we have been able to define 10 different c.2299delG haplotypes, showing high variability but preserving the previously described core haplotype. An exhaustive c.2299delG/control haplotype study suggests that the major source of variability in the USH2A gene is recombination. Furthermore, we have evidenced twice the amount of recombination hotspots located in the 500 kb region that covers the 3′ end of the gene, explaining the higher variability observed in this region when compared with the 250 kb of the 5′ region. Our data confirm the common ancestral origin of the c.2299delG mutation. PMID:20145675

Outbreak of Paratyphoid Fever Among Naval Personnel in Peru (Brote de Fiebre Paratifoidea Entre Personal de la Marina Del Peru.)

DTIC Science & Technology

1992-01-01

son menosde 2Okniquecaiusania nvar comun Cs la tifoidea cldsica producida por S parte de las infecciones hunanas La fiebre Isv’lht la parat-foidea. par...TITLE (Include Secunty Clasifi4tin) Brote de Fiebre Parutifoidea Entre Personal de la Marina del Peru 1.PERSON4AL AUTHORCS) Pazzagllia G; Wgnall FS...CLASSIFIATIO F THIS PAGE All othe~redmtons areobolete. ZINCLASSIITIED Best Avai~lable Copy BROTE Dl FIEBRE PARATIFOIDEA ENTRE PERSONAL DE1 LA MARINA DEL PERU G

How the early voltage clamp studies of José del Castillo inform "modern" neuroscience.

PubMed

Zottoli, Steven J

2012-10-01

The description of ionic currents that flow across the membrane of the squid giant axon during an action potential sparked an interest in determining whether there were similar currents in vertebrates. The preparation of choice was the node of Ranvier in single myelinated fibers in frog. José del Castillo spent 3 years on the United States mainland from 1956 to 1959. During that time, he collaborated with Jerome Y. Lettvin and John W. Moore. I discuss how these individuals met one another and some of their scientific discoveries using the voltage clamp to study squid giant axons and frog nodes. Much of this work was conducted at the Marine Biological Laboratory in Woods Hole, MA, and I attempt to convey a sense of the unique scientific "melting pot" that existed at the Marine Biological Laboratory and the broader effect that del Castillo had on "modern" neuroscience.

Early recovery of subtropical dry forest in southwestern Puerto Rico

Treesearch

Peter L. Weaver

2011-01-01

Tree cover and species composition were surveyed in 1998, 2003, and 2010 after the elimination of grazing and fire on the lower 32 hectares of the Tinaja tract at Laguna Cartagena National Wildlife Refuge in south-western Puerto Rico. Surveys of the secondary subtropical dry forest showed that stems increased 3.9 times, trees 6.7 times, basal area 3.3 times, and...

Grandma's Wicker Sewing Basket: Untangling the Narrative Threads in Silko's "Ceremony"

ERIC Educational Resources Information Center

Beidler, Peter G.; Nelson, Robert M.

2004-01-01

Leslie Marmon Silko's "Ceremony" is a novel about a young man who returns to the Laguna Reservation in 1948, after horrifying experiences on the Pacific front in World War II. He comes home in a psychological mess after being released from a prisoner of war camp. An attempt is made to enable teachers to help first-time readers untangle the various…

Baja California, Mexico

NASA Technical Reports Server (NTRS)

1981-01-01

An interesting view down the axis of Baja California, Mexico (26.5N, 113.0W). At the center of the Scene is Laguna Ojo de Liebre (Bay of Whales) which is a breeding area for the Pacific Grey Whale. The Sea of Cortez, also known as the Gulf of California, is to the left and the Pacific Ocean is to the right.

Containment Area Aquaculture Program. Economics and Marketing of Aquaculture in Dredged Material Containment Areas

DTIC Science & Technology

1993-09-01

project shrimp farm and to use the information learned from the demonstration to examine the economic feasibility of aquaculture in dredged material...aquaculture within the USACE. The Containment Area Aquaculture Program (CAAP) was thus initiated in 1986, as a development of the Environmental ...company. The work of Mariquest was completed in 1989 by Cultured Seafood Group, Inc., Laguna Vista, TX. The

Potential forensic use of a 33 X-InDel panel in the Argentinean population.

PubMed

Caputo, Mariela; Amador, M A; Santos, S; Corach, D

2017-01-01

Polymorphic genetic markers located on the X chromosome might become a complement in particular forensic identification when the biological kinship are deficient. We analyzed forensic statistical parameters of 33 X-chromosome InDel polymorphisms in a sample of 320 individuals from Argentina. The X-chromosome InDel polymorphism (X-InDel) panel was amplified in a single multiplex PCR reaction. Hardy-Weinberg Equilibrium was determined in the female cohort, whereas the male cohort was used to calculate linkage disequilibrium (LD) tested by an extension of Fisher's exact test, D', and Chi-square values. Regarding LD, 15 markers were organized and grouped into six blocks containing two or three linked loci each, namely block I (MID356-MID357), block II (MID448804-MID3703-MID218), block III (MID3705-MID3706-MID304737), block IV (MID197147-MID3754), block V (MID3664-MID284601-MID103547), and block VI (MID3763-MID3728). The haplotype diversity was higher than 0.99 in all cases. Blocks III and VI showed the highest match probability in the studied population, whereas block II showed the lowest. The accumulated power of discrimination was 99.9999991 % in women and 99.9992925 % in men. The mean exclusion chance in trios and duos were 99.9891736 and 99.6099391 %, respectively. Since 15 markers are associated as haplotypic blocks, for a conservative treatment of the data, statistical evaluation should consider their haplotypic frequencies and the remaining 18 markers can be evaluated as independent loci.

Aspetti deontologici e giuridici della Responsabilità professionale del chirurgo in Italia. Evoluzione storica a partire dal '900.

PubMed

Picardi, Nicola

2018-01-01

È pleonastico ricordare che ogni individuo raziocinante delle essere responsabile delle sue azioni: deve agire con la coscienza degli scopi che si propone evitando possibili conseguenze negative dei suoi atti. In ambito medico questo tipo di responsabilità è codificata con le norme della "deontologia". Per secoli l'arte terapeutica è stata praticata da individui dotati di una particolare vocazione ed una particolare cultura acquisita da Maestri dell'arte ancor prima che dalla propria esperienza, con nozioni di erboristeria e di elementari conoscenze anatomiche e di fisiologia, circondati da un'aura sacerdotale e da un rispetto derivante dal timore e dall'ammirazione per il coraggio e auspicabilmente dai successi, e facendo riferimento nell'occidente mediterraneo alle regole operative fissate nel Giuramento di Ippocrate, di significato tra il sacro ed il deontologico. Lo sviluppo delle tecniche anestesiologiche a partire dalla seconda metà dell'800 ha determinato l'ampliamento delle iniziative chirurgiche di tipo elettivo, a fianco con gli storici interventi in emergenza per la cura di lesioni traumatiche, ancor prima delle acquisizioni riguardanti le infezioni. Con l'espansione del campo di azione della chirurgia, le possibili complicanze ed i possibili insuccessi hanno fatto da contrappeso ai sentimenti di rispetto e di fiducia nei confronti dei chirurghi, giungendo a far assimilare in tali casi la loro opera quale causa all'origine di danni, provocati rientrando quindi nella categoria dei reati sottoposti alla Legge penale. Così, al termine deontologico di "responsabilità" valido per ogni iniziativa ed ogni professione, per i medici è venuto ad associarsi la qualifica di "professionale", con un significato di presunta colpevolezza. Da una parte le regole deontologiche si sono ampliate, ed hanno coinvolto direttamente il paziente nella fase decisionale delle terapie chirurgiche, formalizzate programmaticamente in moderni codici deontologici ed

High genetic structure and low mitochondrial diversity in bottlenose dolphins of the Archipelago of Bocas del Toro, Panama: A population at risk?

PubMed Central

Tezanos-Pinto, Gabriela; Islas-Villanueva, Valentina; Correa-Cárdenas, Camilo A.

2017-01-01

The current conservation status of the bottlenose dolphin (Tursiops truncatus) under the IUCN is ‘least concern’. However, in the Caribbean, small and localized populations of the ‘inshore form’ may be at higher risk of extinction than the ‘worldwide distributed form’ due to a combination of factors including small population size, high site fidelity, genetic isolation, and range overlap with human activities. Here, we study the population genetic structure of bottlenose dolphins from the Archipelago of Bocas del Toro in Panama. This is a small population characterized by high site fidelity and is currently heavily-impacted by the local dolphin-watching industry. We collected skin tissue samples from 25 dolphins to study the genetic diversity and structure of this population. We amplified a portion of the mitochondrial Control Region (mtDNA-CR) and nine microsatellite loci. The mtDNA-CR analyses revealed that dolphins in Bocas del Toro belong to the ‘inshore form’, grouped with the Bahamas-Colombia-Cuba-Mexico population unit. They also possess a unique haplotype new for the Caribbean. The microsatellite data indicated that the Bocas del Toro dolphin population is highly structured, likely due to restricted movement patterns. Previous abundance estimates obtained with mark-recapture methods reported a small population of 80 dolphins (95% CI = 72–87), which is similar to the contemporary effective population size estimated in this study (Ne = 73 individuals; CI = 18.0 - ∞; 0.05). The combination of small population size, high degree of genetic isolation, and intense daily interactions with dolphin-watching boats puts the Bocas del Toro dolphin to at high risk of extinction. Despite national guidelines to regulate the dolphin-watching industry in Bocas del Toro and ongoing educational programs for tour operators, only in 2012 seven animals have died due to boat collisions. Our results suggest that the conservation status of bottlenose dolphins in