Sample records for laitila vesa tanttu

  1. A new display stream compression standard under development in VESA

    NASA Astrophysics Data System (ADS)

    Jacobson, Natan; Thirumalai, Vijayaraghavan; Joshi, Rajan; Goel, James

    2017-09-01

    The Advanced Display Stream Compression (ADSC) codec project is in development in response to a call for technologies from the Video Electronics Standards Association (VESA). This codec targets visually lossless compression of display streams at a high compression rate (typically 6 bits/pixel) for mobile/VR/HDR applications. Functionality of the ADSC codec is described in this paper, and subjective trials results are provided using the ISO 29170-2 testing protocol.

  2. The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction

    PubMed Central

    Jackson, Andrew P.; Otto, Thomas D.; Darby, Alistair; Ramaprasad, Abhinay; Xia, Dong; Echaide, Ignacio Eduardo; Farber, Marisa; Gahlot, Sunayna; Gamble, John; Gupta, Dinesh; Gupta, Yask; Jackson, Louise; Malandrin, Laurence; Malas, Tareq B.; Moussa, Ehab; Nair, Mridul; Reid, Adam J.; Sanders, Mandy; Sharma, Jyotsna; Tracey, Alan; Quail, Mike A.; Weir, William; Wastling, Jonathan M.; Hall, Neil; Willadsen, Peter; Lingelbach, Klaus; Shiels, Brian; Tait, Andy; Berriman, Matt; Allred, David R.; Pain, Arnab

    2014-01-01

    Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic diversity in genes encoding VESA (ves1) through comparative analysis within and between three Babesia species, (B. bigemina, B. divergens and B. bovis). Ves1 structure diverges rapidly after speciation, notably through the evolution of shortened forms (ves2) from 5′ ends of canonical ves1 genes. Phylogenetic analyses show that ves1 genes are transposed between loci routinely, whereas ves2 genes are not. Similarly, analysis of sequence mosaicism shows that recombination drives variation in ves1 sequences, but less so for ves2, indicating the adoption of different mechanisms for variation of the two families. Proteomic analysis of the B. bigemina PR isolate shows that two dominant VESA1 proteins are expressed in the population, whereas numerous VESA2 proteins are co-expressed, consistent with differential transcriptional regulation of each family. Hence, VESA2 proteins are abundant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently different to those of VESA1, suggesting that their functions are distinct. PMID:24799432

  3. The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.

    PubMed

    Jackson, Andrew P; Otto, Thomas D; Darby, Alistair; Ramaprasad, Abhinay; Xia, Dong; Echaide, Ignacio Eduardo; Farber, Marisa; Gahlot, Sunayna; Gamble, John; Gupta, Dinesh; Gupta, Yask; Jackson, Louise; Malandrin, Laurence; Malas, Tareq B; Moussa, Ehab; Nair, Mridul; Reid, Adam J; Sanders, Mandy; Sharma, Jyotsna; Tracey, Alan; Quail, Mike A; Weir, William; Wastling, Jonathan M; Hall, Neil; Willadsen, Peter; Lingelbach, Klaus; Shiels, Brian; Tait, Andy; Berriman, Matt; Allred, David R; Pain, Arnab

    2014-06-01

    Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic diversity in genes encoding VESA (ves1) through comparative analysis within and between three Babesia species, (B. bigemina, B. divergens and B. bovis). Ves1 structure diverges rapidly after speciation, notably through the evolution of shortened forms (ves2) from 5' ends of canonical ves1 genes. Phylogenetic analyses show that ves1 genes are transposed between loci routinely, whereas ves2 genes are not. Similarly, analysis of sequence mosaicism shows that recombination drives variation in ves1 sequences, but less so for ves2, indicating the adoption of different mechanisms for variation of the two families. Proteomic analysis of the B. bigemina PR isolate shows that two dominant VESA1 proteins are expressed in the population, whereas numerous VESA2 proteins are co-expressed, consistent with differential transcriptional regulation of each family. Hence, VESA2 proteins are abundant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently different to those of VESA1, suggesting that their functions are distinct. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  4. Status of VESAS: a fully-electronic microwave imaging radiometer system

    NASA Astrophysics Data System (ADS)

    Schreiber, Eric; Peichl, Markus; Suess, Helmut

    2010-04-01

    Present applications of microwave remote sensing systems cover a large variety. One utilisation of the frequency range from 1 - 300 GHz is the domain of security and reconnaissance. Examples are the observation of critical infrastructures or the performance of security checks on people in order to detect concealed weapons or explosives, both being frequent threats in our world of growing international terrorism. The imaging capability of concealed objects is one of the main advantages of microwave remote sensing, because of the penetration performance of electromagnetic waves through dielectric materials in this frequency domain. The main physical effects used in passive microwave sensing rely on the naturally generated thermal radiation and the physical properties of matter, the latter being surface characteristics, chemical and physical composition, and the temperature of the material. As a consequence it is possible to discriminate objects having different material characteristics like ceramic weapons or plastic explosives with respect to the human body. Considering the use of microwave imaging with respect to people scanning systems in airports, railway stations, or stadiums, it is advantageous that passively operating devices generate no exposure on the scanned objects like actively operating devices do. For frequently used security gateways it is additionally important to have a high through-put rate in order to minimize the queue time. Consequently fast imaging systems are necessary. In this regard the conceptual idea of a fully-electronic microwave imaging radiometer system is introduced. The two-dimensional scanning mechanism is divided into a frequency scan in one direction and the method of aperture synthesis in the other. The overall goal here is to design a low-cost, fully-electronic imaging system with a frame rate of around one second at Ka band. This frequency domain around a center frequency of 37 GHz offers a well-balanced compromise between the achievable spatial resolution for a given size, and the penetration depth of the electromagnetic wave, which are conflictive requirements.

  5. The Sim-SEQ Project: Comparison of Selected Flow Models for the S-3 Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mukhopadhyay, Sumit; Doughty, Christine A.; Bacon, Diana H.

    Sim-SEQ is an international initiative on model comparison for geologic carbon sequestration, with an objective to understand and, if possible, quantify model uncertainties. Model comparison efforts in Sim-SEQ are at present focusing on one specific field test site, hereafter referred to as the Sim-SEQ Study site (or S-3 site). Within Sim-SEQ, different modeling teams are developing conceptual models of CO2 injection at the S-3 site. In this paper, we select five flow models of the S-3 site and provide a qualitative comparison of their attributes and predictions. These models are based on five different simulators or modeling approaches: TOUGH2/EOS7C, STOMP-CO2e,more » MoReS, TOUGH2-MP/ECO2N, and VESA. In addition to model-to-model comparison, we perform a limited model-to-data comparison, and illustrate how model choices impact model predictions. We conclude the paper by making recommendations for model refinement that are likely to result in less uncertainty in model predictions.« less

  6. Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors.

    PubMed

    Eichenberger, Ramon M; Ramakrishnan, Chandra; Russo, Giancarlo; Deplazes, Peter; Hehl, Adrian B

    2017-06-13

    Infections of dogs with virulent strains of Babesia canis are characterized by rapid onset and high mortality, comparable to complicated human malaria. As in other apicomplexan parasites, most Babesia virulence factors responsible for survival and pathogenicity are secreted to the host cell surface and beyond where they remodel and biochemically modify the infected cell interacting with host proteins in a very specific manner. Here, we investigated factors secreted by B. canis during acute infections in dogs and report on in silico predictions and experimental analysis of the parasite's exportome. As a backdrop, we generated a fully annotated B. canis genome sequence of a virulent Hungarian field isolate (strain BcH-CHIPZ) underpinned by extensive genome-wide RNA-seq analysis. We find evidence for conserved factors in apicomplexan hemoparasites involved in immune-evasion (e.g. VESA-protein family), proteins secreted across the iRBC membrane into the host bloodstream (e.g. SA- and Bc28 protein families), potential moonlighting proteins (e.g. profilin and histones), and uncharacterized antigens present during acute crisis in dogs. The combined data provides a first predicted and partially validated set of potential virulence factors exported during fatal infections, which can be exploited for urgently needed innovative intervention strategies aimed at facilitating diagnosis and management of canine babesiosis.

  7. Stereoscopic-3D display design: a new paradigm with Intel Adaptive Stable Image Technology [IA-SIT

    NASA Astrophysics Data System (ADS)

    Jain, Sunil

    2012-03-01

    Stereoscopic-3D (S3D) proliferation on personal computers (PC) is mired by several technical and business challenges: a) viewing discomfort due to cross-talk amongst stereo images; b) high system cost; and c) restricted content availability. Users expect S3D visual quality to be better than, or at least equal to, what they are used to enjoying on 2D in terms of resolution, pixel density, color, and interactivity. Intel Adaptive Stable Image Technology (IA-SIT) is a foundational technology, successfully developed to resolve S3D system design challenges and deliver high quality 3D visualization at PC price points. Optimizations in display driver, panel timing firmware, backlight hardware, eyewear optical stack, and synch mechanism combined can help accomplish this goal. Agnostic to refresh rate, IA-SIT will scale with shrinking of display transistors and improvements in liquid crystal and LED materials. Industry could profusely benefit from the following calls to action:- 1) Adopt 'IA-SIT S3D Mode' in panel specs (via VESA) to help panel makers monetize S3D; 2) Adopt 'IA-SIT Eyewear Universal Optical Stack' and algorithm (via CEA) to help PC peripheral makers develop stylish glasses; 3) Adopt 'IA-SIT Real Time Profile' for sub-100uS latency control (via BT Sig) to extend BT into S3D; and 4) Adopt 'IA-SIT Architecture' for Monitors and TVs to monetize via PC attach.

  8. UWGSP7: a real-time optical imaging workstation

    NASA Astrophysics Data System (ADS)

    Bush, John E.; Kim, Yongmin; Pennington, Stan D.; Alleman, Andrew P.

    1995-04-01

    With the development of UWGSP7, the University of Washington Image Computing Systems Laboratory has a real-time workstation for continuous-wave (cw) optical reflectance imaging. Recent discoveries in optical science and imaging research have suggested potential practical use of the technology as a medical imaging modality and identified the need for a machine to support these applications in real time. The UWGSP7 system was developed to provide researchers with a high-performance, versatile tool for use in optical imaging experiments with the eventual goal of bringing the technology into clinical use. One of several major applications of cw optical reflectance imaging is tumor imaging which uses a light-absorbing dye that preferentially sequesters in tumor tissue. This property could be used to locate tumors and to identify tumor margins intraoperatively. Cw optical reflectance imaging consists of illumination of a target with a band-limited light source and monitoring the light transmitted by or reflected from the target. While continuously illuminating the target, a control image is acquired and stored. A dye is injected into a subject and a sequence of data images are acquired and processed. The data images are aligned with the control image and then subtracted to obtain a signal representing the change in optical reflectance over time. This signal can be enhanced by digital image processing and displayed in pseudo-color. This type of emerging imaging technique requires a computer system that is versatile and adaptable. The UWGSP7 utilizes a VESA local bus PC as a host computer running the Windows NT operating system and includes ICSL developed add-on boards for image acquisition and processing. The image acquisition board is used to digitize and format the analog signal from the input device into digital frames and to the average frames into images. To accommodate different input devices, the camera interface circuitry is designed in a small mezzanine board