Science.gov

Sample records for lambda particles

  1. {Lambda} single particle energies

    SciTech Connect

    Usmani, Q.N.; Bodmer, A.R. |

    1999-11-01

    The {Lambda} single-particle energies B{sub {Lambda}} of hypernuclei (HN) are calculated microscopically using the Fermi hypernetted chain method to obtain for our {Lambda}N and {Lambda}NN potentials the {Lambda} binding D({rho}) to nuclear matter, and the effective mass m{sub {Lambda}}{sup {asterisk}}({rho}) at densities {rho}{le}{rho}{sub 0} ({rho}{sub 0} is normal nuclear density), and also the corresponding effective {Lambda}N and {Lambda}NN potentials. The {Lambda} core-nucleus potential U{sub {Lambda}}(r) is obtained by suitably folding these into the core density. The Schr{umlt o}dinger equation for U{sub {Lambda}} and m{sub {Lambda}}{sup {asterisk}} is solved for B{sub {Lambda}}. The fringing field (FF) due to the finite range of the effective potentials is theoretically required. We use a dispersive {Lambda}NN potential but also include a phenomenological {rho} dependence allowing for less repulsion for {rho}{lt}{rho}{sub 0}, i.e., in the surface. The best fits to the data with a FF give a large {rho} dependence, equivalent to an {ital A} dependent strength consistent with variational calculations of {sub {Lambda}}{sup 5}He, indicating an effective {Lambda}NN dispersive potential increasingly repulsive with {ital A} whose likely interpretation is in terms of dispersive plus two-pion-exchange {Lambda}NN potentials. The well depth is 29{plus_minus}1&hthinsp;MeV. The {Lambda}N space-exchange fraction corresponds to m{sub {Lambda}}{sup {asterisk}}({rho}){approx}0.75{endash}0.80 and a ratio of {ital p}- to {ital s}-state potentials of {approx}0.5{plus_minus}0.1. Charge symmetry breaking (CSB) is significant for heavy HN with a large neutron excess; with a FF the strength agrees with that obtained from the A=4&hthinsp;HN. The fits without FF are excellent but inconsistent with the requirement for a FF, with {sub {Lambda}}{sup 5}He, and also with the CSB sign for A=4. {copyright} {ital 1999} {ital The American Physical Society}

  2. {Lambda} single-particle energies

    SciTech Connect

    Bodmer, A.R.; Usmani, Q.N.; Sami, M.

    1995-08-01

    We are continuing our work on the {Lambda} hyperon single-particle (s.p.) energies and their interpretation in terms of the basic {Lambda}-nuclear interactions. In particular we are interpreting the results obtained by S.C. Pieper, A. Usmani and Q.N. Usmani. We obtain about 30 MeV for the repulsive contribution of the three-body {Lambda}NN forces in nuclear matter. We are able to exclude purely {open_quotes}dispersive{close_quotes} {Lambda}NN forces. We are investigating the mix of dispersive and two-pion-exchange {Lambda}NN forces which provide a fit to the s.p. data. For interactions, which provide a fit to the s.p. data, the {Lambda} binding energy as a function of the nuclear matter density shows characteristic saturation features with a maximum at a density not very different from that of normal nuclear matter. We obtain a more precise measure of the space-exchange part of the {Lambda}-nuclear force than was previously available, corresponding to an exchange parameter {approx_equal} 0.32. The space-exchange force is rather directly related to the effective mass of a {Lambda} in the nuclear medium and turns out to be about 70% of its free mass. As a result, we also obtain a much better value for the p-state {Lambda}-nucleus potential which is about 40% of the s-state potential. The A binding to nuclear matter is determined to be {approx_equal} 28 MeV.

  3. Microscopic calculations of {lambda} single-particle energies.

    SciTech Connect

    Usmani, Q. N.

    1998-02-12

    {Lambda} binding energy data for total baryon number A {le} 208 and for {Lambda} angular momenta {ell}{sub {Lambda}} {le} 3 are analyzed in terms of phenomenological (but generally consistent with meson-exchange) {Lambda}N and {Lambda}NN potentials. The Fermi-Hypernetted-Chain technique is used to calculate the expectation values for the {Lambda} binding to nuclear matter. Accurate effective {Lambda}N and {Lambda}NN potentials are obtained which are folded with the core nucleus nucleon densities to calculate the {Lambda} single particle potential U{sub {Lambda}}(r). We use a dispersive {Lambda}NN potential but also include an explicit {rho} dependence to allow for reduced repulsion in the surface, and the best fits have a large {rho} dependence giving consistency with the variational Monte Carlo calculations for {sub {Lambda}}{sup 5}He. The exchange fraction of the {Lambda}N space-exchange potential is found to be 0.2-0.3 corresponding to m{sub {Lambda}}* {approx_equal} (0.74-0.82)m{sub {Lambda}}. Charge symmetry breaking is found to be significant for heavy hypernuclei with a large neutron excess, with a strength consistent with that obtained from the A = 4 hypernuclei.

  4. The hydrophilic amino-terminal arm of reovirus core shell protein lambda1 is dispensable for particle assembly.

    PubMed

    Kim, Jonghwa; Zhang, Xing; Centonze, Victoria E; Bowman, Valorie D; Noble, Simon; Baker, Timothy S; Nibert, Max L

    2002-12-01

    The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses and rotaviruses, we used recombinant baculoviruses to coexpress reovirus core proteins lambda1, lambda2, and sigma2 in insect cells. The resulting core-like particles (CLPs) were purified and characterized. They were found to be similar to cores with regard to their sizes, morphologies, and protein compositions. Like cores, they could also be coated in vitro with the two major outer-capsid proteins, micro 1 and sigma3, to produce virion-like particles. Coexpression of core shell protein lambda1 and core nodule protein sigma2 was sufficient to yield CLPs that could withstand purification, whereas expression of lambda1 alone was not, indicating a required role for sigma2 as a previous study also suggested. In addition, CLPs that lacked lambda2 (formed from lambda1 and sigma2 only) could not be coated with micro 1 and sigma3, indicating a required role for lambda2 in the assembly of these outer-capsid proteins into particles. To extend the use of this system for understanding the core and its assembly, we addressed the hypothesis that the hydrophilic amino-terminal region of lambda1, which adopts an extended arm-like conformation around each threefold axis in the reovirus core crystal structure, plays an important role in assembling the core shell. Using a series of lambda1 deletion mutants, we showed that the amino-terminal 230 residues of lambda1, including its zinc finger, are dispensable for CLP assembly. Residues in the 231-to-259 region of lambda1, however, were required. The core crystal structure suggests that residues in the 231-to-259 region are necessary because they affect the interaction of lambda1 with the threefold and/or fivefold copies of

  5. Measurement of Lambda and Lambda(macro) particles in Au+Au collisions at the square root of S(NN) = 130 GeV.

    PubMed

    Adcox, K; Adler, S S; Ajitanand, N N; Akiba, Y; Alexander, J; Aphecetche, L; Arai, Y; Aronson, S H; Averbeck, R; Awes, T C; Barish, K N; Barnes, P D; Barrette, J; Bassalleck, B; Bathe, S; Baublis, V; Bazilevsky, A; Belikov, S; Bellaiche, F G; Belyaev, S T; Bennett, M J; Berdnikov, Y; Botelho, S; Brooks, M L; Brown, D S; Bruner, N; Bucher, D; Buesching, H; Bumazhnov, V; Bunce, G; Burward-Hoy, J; Butsyk, S; Carey, T A; Chand, P; Chang, J; Chang, W C; Chavez, L L; Chernichenko, S; Chi, C Y; Chiba, J; Chiu, M; Choudhury, R K; Christ, T; Chujo, T; Chung, M S; Chung, P; Cianciolo, V; Cole, B A; D'Enterria, D G; David, G; Delagrange, H; Denisov, A; Deshpande, A; Desmond, E J; Dietzsch, O; Dinesh, B V; Drees, A; Durum, A; Dutta, D; Ebisu, K; Efremenko, Y V; el-Chenawi, K; En'yo, H; Esumi, S; Ewell, L; Ferdousi, T; Fields, D E; Fokin, S L; Fraenkel, Z; Franz, A; Frawley, A D; Fung, S-Y; Garpman, S; Ghosh, T K; Glenn, A; Godoi, A L; Goto, Y; Greene, S V; Grosse Perdekamp, M; Gupta, S K; Guryn, W; Gustafsson, H-A; Haggerty, J S; Hamagaki, H; Hansen, A G; Hara, H; Hartouni, E P; Hayano, R; Hayashi, N; He, X; Hemmick, T K; Heuser, J M; Hibino, M; Hill, J C; Ho, D S; Homma, K; Hong, B; Hoover, A; Ichihara, T; Imai, K; Ippolitov, M S; Ishihara, M; Jacak, B V; Jang, W Y; Jia, J; Johnson, B M; Johnson, S C; Joo, K S; Kametani, S; Kang, J H; Kann, M; Kapoor, S S; Kelly, S; Khachaturov, B; Khanzadeev, A; Kikuchi, J; Kim, D J; Kim, H J; Kim, S Y; Kim, Y G; Kinnison, W W; Kistenev, E; Kiyomichi, A; Klein-Boesing, C; Klinksiek, S; Kochenda, L; Kochetkov, V; Koehler, D; Kohama, T; Kotchetkov, D; Kozlov, A; Kroon, P J; Kurita, K; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lajoie, J G; Lauret, J; Lebedev, A; Lee, D M; Leitch, M J; Li, X H; Li, Z; Lim, D J; Liu, M X; Liu, X; Liu, Z; Maguire, C F; Mahon, J; Makdisi, Y I; Manko, V I; Mao, Y; Mark, S K; Markacs, S; Martinez, G; Marx, M D; Masaike, A; Matathias, F; Matsumoto, T; McGaughey, P L; Melnikov, E; Merschmeyer, M; Messer, F; Messer, M; Miake, Y; Miller, T E; Milov, A; Mioduszewski, S; Mischke, R E; Mishra, G C; Mitchell, J T; Mohanty, A K; Morrison, D P; Moss, J M; Mühlbacher, F; Mukhopadhyay, D; Muniruzzaman, M; Murata, J; Nagamiya, S; Nagasaka, Y; Nagle, J L; Nakada, Y; Nandi, B K; Newby, J; Nikkinen, L; Nilsson, P; Nishimura, S; Nyanin, A S; Nystrand, J; O'Brien, E; Ogilvie, C A; Ohnishi, H; Ojha, I D; Ono, M; Onuchin, V; Oskarsson, A; Osterman, L; Otterlund, I; Oyama, K; Paffrath, L; Pal, D; Palounek, A P T; Pantuev, V S; Papavassiliou, V; Pate, S F; Peitzmann, T; Petridis, A N; Pinkenburg, C; Pisani, R P; Pitukhin, P; Plasil, F; Pollack, M; Pope, K; Purschke, M L; Ravinovich, I; Read, K F; Reygers, K; Riabov, V; Riabov, Y; Rosati, M; Rose, A A; Ryu, S S; Saito, N; Sakaguchi, A; Sakaguchi, T; Sako, H; Sakuma, T; Samsonov, V; Sangster, T C; Santo, R; Sato, H D; Sato, S; Sawada, S; Schlei, B R; Schutz, Y; Semenov, V; Seto, R; Shea, T K; Shein, I; Shibata, T-A; Shigaki, K; Shiina, T; Shin, Y H; Sibiriak, I G; Silvermyr, D; Sim, K S; Simon-Gillo, J; Singh, C P; Singh, V; Sivertz, M; Soldatov, A; Soltz, R A; Sorensen, S; Stankus, P W; Starinsky, N; Steinberg, P; Stenlund, E; Ster, A; Stoll, S P; Sugioka, M; Sugitate, T; Sullivan, J P; Sumi, Y; Sun, Z; Suzuki, M; Takagui, E M; Taketani, A; Tamai, M; Tanaka, K H; Tanaka, Y; Taniguchi, E; Tannenbaum, M J; Thomas, J; Thomas, J H; Thomas, T L; Tian, W; Tojo, J; Torii, H; Towell, R S; Tserruya, I; Tsuruoka, H; Tsvetkov, A A; Tuli, S K; Tydesjö, H; Tyurin, N; Ushiroda, T; Van Hecke, H W; Velissaris, C; Velkovska, J; Velkovsky, M; Vinogradov, A A; Volkov, M A; Vorobyov, A; Vznuzdaev, E; Wang, H; Watanabe, Y; White, S N; Witzig, C; Wohn, F K; Woody, C L; Xie, W; Yagi, K; Yokkaichi, S; Young, G R; Yushmanov, I E; Zajc, W A; Zhang, Z; Zhou, S; Zhou, S

    2002-08-26

    We present results on the measurement of Lambda and Lambda(macro) production in Au+Au collisions at square root of (S (NN) = 130 GeV with the PHENIX detector at the Relativistic Heavy Ion Collider. The transverse momentum spectra were measured for minimum bias and for the 5% most central events. The Lambda;/Lambda ratios are constant as a function of p(T) and the number of participants. The measured net Lambda density is significantly larger than predicted by models based on hadronic strings (e.g., HIJING) but in approximate agreement with models which include the gluon-junction mechanism.

  6. Lightest Double-Lambda Hypernucleus

    NASA Astrophysics Data System (ADS)

    Nakaichi-Maeda, S.; Akaishi, Y.

    1990-12-01

    A variational calculation for (4) _{Lambda Lambda}H is made by employing the phenomenological N Lambda and Lambda Lambda potentials derived recently. It is shown that the binding of (4) _{Lambda Lambda}H below the Lambda+(3}_{Lambda) H threshold is consistent with the (6) _{Lambda Lambda}He data, and also with the (10) _{Lambda Lambda}Be data when repulsive alpha alpha Lambda and alpha Lambda Lambda three-body forces are considered.

  7. Localized N, {lambda}, {sigma}, and {xi} single-particle potentials in finite nuclei calculated with SU{sub 6} quark-model baryon-baryon interactions

    SciTech Connect

    Kohno, M.; Fujiwara, Y.

    2009-05-15

    Localized single-particle potentials for all octet baryons, N, {lambda}, {sigma}, and {xi}, in finite nuclei, {sup 12}C, {sup 16}O, {sup 28}Si, {sup 40}Ca, {sup 56}Fe, and {sup 90}Zr, are calculated using the quark-model baryon-baryon interactions. G matrices evaluated in symmetric nuclear matter in the lowest order Brueckner theory (LOBT) are applied to finite nuclei in local density approximation. Nonlocal potentials are localized by a zero-momentum Wigner transformation. Empirical single-particle properties of the nucleon and the {lambda} hyperon in a nuclear medium have been known to be explained semiquantitatively in the LOBT framework. Attention is focused in the present consideration on predictions for the {sigma} and {xi} hyperons. The unified description for the octet baryon-baryon interactions by the SU{sub 6} quark model enables us to obtain less ambiguous extrapolation to the S=-1 and S=-2 sectors based on the knowledge in the NN sector than other potential models. The {sigma} mean field is shown to be weakly attractive at the surface, but turns out to be repulsive inside, which is consistent with the experimental evidence. The {xi} hyperon s.p. potential is also attractive at the nuclear surface region, and inside it fluctuates around zero. Hence {xi} hypernuclear bound states are unlikely. We also evaluate energy shifts of the {sigma}{sup -} and {xi}{sup -} atomic levels in {sup 28}Si and {sup 56}Fe, using the calculated s.p. potentials.

  8. Lambda Vision

    NASA Astrophysics Data System (ADS)

    Czajkowski, Michael

    2014-06-01

    There is an explosion in the quantity and quality of IMINT data being captured in Intelligence Surveillance and Reconnaissance (ISR) today. While automated exploitation techniques involving computer vision are arriving, only a few architectures can manage both the storage and bandwidth of large volumes of IMINT data and also present results to analysts quickly. Lockheed Martin Advanced Technology Laboratories (ATL) has been actively researching in the area of applying Big Data cloud computing techniques to computer vision applications. This paper presents the results of this work in adopting a Lambda Architecture to process and disseminate IMINT data using computer vision algorithms. The approach embodies an end-to-end solution by processing IMINT data from sensors to serving information products quickly to analysts, independent of the size of the data. The solution lies in dividing up the architecture into a speed layer for low-latent processing and a batch layer for higher quality answers at the expense of time, but in a robust and fault-tolerant way. This approach was evaluated using a large corpus of IMINT data collected by a C-130 Shadow Harvest sensor over Afghanistan from 2010 through 2012. The evaluation data corpus included full motion video from both narrow and wide area field-of-views. The evaluation was done on a scaled-out cloud infrastructure that is similar in composition to those found in the Intelligence Community. The paper shows experimental results to prove the scalability of the architecture and precision of its results using a computer vision algorithm designed to identify man-made objects in sparse data terrain.

  9. Shell-model predictions for Lambda Lambda hypernuclei

    SciTech Connect

    Gal, A.; Millener, D.

    2011-06-02

    It is shown how the recent shell-model determination of {Lambda}N spin-dependent interaction terms in {Lambda} hypernuclei allows for a reliable deduction of {Lambda}{Lambda} separation energies in {Lambda}{Lambda} hypernuclei across the nuclear p shell. Comparison is made with the available data, highlighting {sub {Lambda}{Lambda}}{sup 11}Be and {sub {Lambda}{Lambda}}{sup 12}Be which have been suggested as possible candidates for the KEK-E373 HIDA event.

  10. The Dependence of Cirrus Gamma Size Distributions Expressed as Volumes in N(sub 0)-Lambda-Mu Phase Space and Bulk Cloud Properties on Environmental Conditions: Results from the Small Ice Particles in Cirrus Experiment (SPARTICUS)

    NASA Technical Reports Server (NTRS)

    Jackson, Robert C.; McFarquhar, Greg M.; Fridlind, Ann M.; Atlas, Rachel

    2015-01-01

    The variability of cirrus ice microphysical properties is investigated using observations obtained during the Small Particles in Cirrus (SPARTICUS) campaign. An existing approach that represents a size distribution (SD) as a single gamma function using an ellipsoid of equally realizable solutions in (N(sub 0), lambda, mu) phase space is modified to automatically identify multiple modes in SDs and characterize each mode by such an ellipsoid. The modified approach is applied to ice crystals with maximum dimension D greater than15 micrometers collected by the 2-D stereo and 2-D precipitation probes on the Stratton Park Engineering Company Learjet. The dependencies of N(sub 0), mu, and lambda from each mode, total number concentration, bulk extinction, ice water content (IWC), and mass median maximum dimension D(sub mm) as a function of temperature T and cirrus type are then analyzed. The changes in the observed codependencies between N(sub 0), mu, and lambda, bulk extinction, IWC, and D(sub mm) with environmental conditions indicate that particles were larger at higher T during SPARTICUS. At most two modes were observed in any SD during SPARTICUS, with the average boundary between them at 115 micrometers, similar to past studies not using probes with shatter mitigating tips and artifact removal algorithms. The bimodality of the SDs increased with T. This and the differences in N(sub 0), mu, and lambda between the modes suggest that particles with smaller D nucleated more recently than particles with larger D, which grew via vapor deposition and aggregation. Because smaller crystals, whose concentrations are uncertain, make marginal contributions to higher order moments, the use of higher moments for evaluating model fields is suggested.

  11. The Dependence of Cirrus Gamma Size Distributions Expressed as Volumes in N(sub 0)-Lambda-Mu Phase Space and Bulk Cloud Properties on Environmental Conditions: Results from the Small Ice Particles in Cirrus Experiment (SPARTICUS)

    NASA Technical Reports Server (NTRS)

    Jackson, Robert C.; McFarquhar, Greg M.; Fridlind, Ann M.; Atlas, Rachel

    2015-01-01

    The variability of cirrus ice microphysical properties is investigated using observations obtained during the Small Particles in Cirrus (SPARTICUS) campaign. An existing approach that represents a size distribution (SD) as a single gamma function using an ellipsoid of equally realizable solutions in (N(sub 0), lambda, mu) phase space is modified to automatically identify multiple modes in SDs and characterize each mode by such an ellipsoid. The modified approach is applied to ice crystals with maximum dimension D greater than15 micrometers collected by the 2-D stereo and 2-D precipitation probes on the Stratton Park Engineering Company Learjet. The dependencies of N(sub 0), mu, and lambda from each mode, total number concentration, bulk extinction, ice water content (IWC), and mass median maximum dimension D(sub mm) as a function of temperature T and cirrus type are then analyzed. The changes in the observed codependencies between N(sub 0), mu, and lambda, bulk extinction, IWC, and D(sub mm) with environmental conditions indicate that particles were larger at higher T during SPARTICUS. At most two modes were observed in any SD during SPARTICUS, with the average boundary between them at 115 micrometers, similar to past studies not using probes with shatter mitigating tips and artifact removal algorithms. The bimodality of the SDs increased with T. This and the differences in N(sub 0), mu, and lambda between the modes suggest that particles with smaller D nucleated more recently than particles with larger D, which grew via vapor deposition and aggregation. Because smaller crystals, whose concentrations are uncertain, make marginal contributions to higher order moments, the use of higher moments for evaluating model fields is suggested.

  12. Study of the decay asymmetry parameter and CP violation parameter in the Lambda(c)+ ---> Lambda pi+ decay

    SciTech Connect

    Link, J.M.; Yager, P.M.; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN, Pavia /Rio de Janeiro, Pont. U. Catol. /Puerto Rico U., Mayaguez /South Carolina U. /Tennessee U. /Vanderbilt U. /Wisconsin U., Madison

    2005-09-01

    Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement of the weak decay-asymmetry parameter a{sub {Lambda}{sub c}} in {Lambda}{sub c}{sup +} {yields} {Lambda}{pi}{sup +} decay. Comparing particle with antiparticle decays, we obtain the first measurement of the CP violation parameter {Alpha} {triple_bond} a{sub {Lambda}{sub c}} + a{sub {ovr {Lambda}{sub c}}}/a{sub {Lambda}{sub c}} - a{sub {ovr {Lambda}{sub c}}}. We obtain a{sub {Lambda}{sub c}} = -0.78 {+-} 0.16 {+-} 0.13 and {Alpha} = -0.07 {+-} 0.19 {+-} 0.12 where errors are statistical and systematic.

  13. What does the free space Lambda Lambda interaction predict for Lambda Lambda hypernuclei?

    PubMed

    Albertus, C; Amaro, J E; Nieves, J

    2002-07-15

    Data on LambdaLambda hypernuclei provide a unique method to learn details about the strangeness S = -2 sector of the baryon-baryon interaction. From the free space Bonn-Jülich potentials, determined from data on baryon-baryon scattering in the S = 0,-1 channels, we construct an interaction in the S = -2 sector to describe the experimentally known LambdaLambda hypernuclei. After including short-range (Jastrow) and RPA correlations, we find masses for these LambdaLambda hypernuclei in a reasonable agreement with data, taking into account theoretical and experimental uncertainties. Thus, we provide a natural extension, at low energies, of the Bonn-Jülich one-boson exchange potentials to the S = -2 channel.

  14. {lambda}(1520) {yields} {lambda}{gamma} Radiative-Decay Width

    SciTech Connect

    Vavilov, D.V.; Antipov, Yu.M.; Artamonov, A.V.; Batarin, V.A.; Victorov, V.A.; Golovkin, S.V.; Gorin, Yu.P.; Eroshin, O.V.; Kozhevnikov, A.P.; Konstantinov, A.S.; Kubarovsky, V.P.; Kurshetsov, V.F.; Landsberg, L.G.; Leontiev, V.M.; Molchanov, V.V.; Mukhin, V.A.; Patalakha, D.I.; Petrenko, S.V.; Petrukhin, A.I.; Kolganov, V.Z.

    2005-03-01

    The radiative decay {lambda}(1520) {yields} {lambda}{gamma} was recorded in the exclusive reaction p + N {yields} {lambda}(1520)K{sup +} + N at the SPHINX facility. The branching ratio for this decay and the corresponding partial width were found to be, respectively, Br[{lambda}(1520) {yields} {lambda}{gamma}] = (1.02 {+-} 0.21) x 10{sup -2} and {gamma}[{lambda}(1520) {yields} {lambda}{gamma}] = 159 {+-} 35 keV (the quoted errors are purely statistical, the systematic errors being within 15%)

  15. lambda. and. sigma. hypernuclei

    SciTech Connect

    Millener, D.J.

    1985-01-01

    The present status of structure calculations for p-shell ..lambda.. hypernuclei, including the phenomenological determination of ..lambda..N effective interaction matrix elements, is briefly reviewed. For ..sigma.. hypernuclei the Nijmegen potential model D is used for guidance in constructing ..sigma..N effective interactions. The structure of /sub ..sigma..//sup 12/Be and /sub ..sigma..//sup 12/C, including isospin mixing in the later case, is discussed, and a comparison is made with experimental data. 19 refs., 5 figs., 4 tabs.

  16. Measurement of the Lambda b lifetime in the exclusive decay Lambda b --> J/psi Lambda.

    PubMed

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Jesus, A C S Assis; Atramentov, O; Autermann, C; Avila, C; Ay, C; Badaud, F; Baden, A; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Berntzon, L; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Borissov, G; Bos, K; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Burdin, S; Burke, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Caron, S; Carvalho, W; Casey, B C K; Cason, N M; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K; Chan, K M; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clément, B; Clément, C; Coadou, Y; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Crépé-Renaudin, S; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, G; De, K; de Jong, P; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Ford, M; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Galyaev, E; Garcia, C; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Gelé, D; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gollub, N; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Hanagaki, K; Hansson, P; Harder, K; Harel, A; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hooper, R; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Käfer, D; Kahn, S; Kajfasz, E; Kalinin, A M; Kalk, J M; Kalk, J R; Kappler, S; Karmanov, D; Kasper, J; Kasper, P; Katsanos, I; Kau, D; Kaur, R; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y M; Khatidze, D; Kim, H; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J-P; Kopal, M; Korablev, V M; Kothari, B; Kozelov, A V; Krop, D; Kryemadhi, A; Kuhl, T; Kumar, A; Kunori, S; Kupco, A; Kurca, T; Kvita, J; Lam, D; Lammers, S; Landsberg, G; Lazoflores, J; Lebrun, P; Lee, W M; Leflat, A; Lehner, F; Lellouch, J; Lesne, V; Leveque, J; Lewis, P; Li, J; Li, L; Li, Q Z; Lietti, S M; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobo, L; Lobodenko, A; Lokajicek, M; Lounis, A; Love, P; Lubatti, H J; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Makovec, N; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martin, B; McCarthy, R; Melnitchouk, A; Mendes, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Michaut, M; Millet, T; Mitrevski, J; Molina, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulders, M; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Noeding, C; Nomerotski, A; Novaes, S F; Nunnemann, T; O'dell, V; O'neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osta, J; Otec, R; Otero Y Garzón, G J; Owen, M; Padley, P; Pangilinan, M; Panikashvili, N; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Perea, P M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Pompos, A; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Rani, K J; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schieferdecker, P; Schliephake, T; Schmitt, C; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Sengupta, S; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Shpakov, D; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Smith, R P; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Souza, M; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stone, A; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, M; Ströhmer, R; Strom, D; Strovink, M; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Talby, M; Tamburello, P; Tanasijczuk, A; Taylor, W; Telford, P; Temple, J; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Tomoto, M; Toole, T; Torchiani, I; Trefzger, T; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; van Eijk, B; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vartapetian, A; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Seguier, F; Vint, P; Von Toerne, E; Voutilainen, M; Vreeswijk, M; Wagner, R; Wahl, H D; Wang, L; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Weerts, H; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yip, K; Yoo, H D; Youn, S W; Yu, C; Yu, J; Yurkewicz, A; Zatserklyaniy, A; Zeitnitz, C; Zhang, D; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2007-10-05

    We have measured the Lambda b lifetime using the exclusive decay Lambda b --> J/psi Lambda, based on 1.2 fb(-1) of data collected with the D0 detector during 2002-2006. From 171 reconstructed Lambda b decays, where the J/psi and Lambda are identified via the decays J/psi --> mu+ mu- and Lambda --> ppi, we measured the Lambda b lifetime to be tau(Lambda b)=1.218 (+0.130)/(-0.115) (stat) +/- 0.042(syst) ps. We also measured the B0 lifetime in the decay B0 --> J/psi(mu+ mu-)K(0)/(S)(pi+ pi-) to be tau(B0)=1.501 (+0.078)/(-0.074) (stat) +/- 0.050(syst) ps, yielding a lifetime ratio of tau(Lambda b)/tau(B0)=0.811 (+0.096)/(-0.087) (stat) +/- 0.034(syst).

  17. Life of Lambda

    ERIC Educational Resources Information Center

    Futhey, Tracy

    2005-01-01

    In this column, the author discusses the four key questions related to the National LambdaRail (NLR) networking technology. NLR uses Dense Wave Division Multiplexing (DWDM) to enable multiple networks to coexist on a national fiber footprint, and is owned and operated not by carriers, but by the research and education community. The NLR Board…

  18. Preparation and assay of phage lambda.

    PubMed

    Dale, J W; Greenaway, P J

    1985-01-01

    Lambda, a temperate bacteriophage of E. coli, has two alternative modes of replication in sensitive cells, known as the lytic and lysogenic cycles. In the lytic cycle, after the lambda DNA enters the cells, various phage functions are expressed that result in the production of a large number of mature phage particles and cell lysis. In the lysogenic mode, which normally occurs in only a small proportion of the infected cells, the phage forms a more or less stable relationship with the host bacterium; this stable state is known as lysogeny. In a lysogenic cell, phage DNA is normally incorporated into the chromosomal DNA via specific attachment sites on both the phage DNA and the host chromosome. Replication of lambda DNA then occurs only during replication of the host chromosome, and the phage genome is inherited by each daughter cell at cell division. The phage is maintained in this prophage state through the action of a repressor protein, coded for by the phage gene cl. This repressor protein turns off the expression of virtually the whole of the lambda genome. If the repressor is inactivated, the expression of phage genes is initiated. This leads to the excision of lambda DNA from the host chromosome and entry into the lytic cycle. The balance between the lytic and lysogenic modes of replication is a delicate and complex one in which a key factor is the concentration of the cl gene product. Some of the many sources of further information about the basic biology of lambda phage are listed in the references to this chapter.

  19. PROTON - LAMBDA CORRELATIONS IN AU-AU COLLISIONS AT SQUARE ROOT NN = 200 GEV FROM THE STAR EXPERIMENT.

    SciTech Connect

    RENAULT,G.

    2004-03-15

    The space-time evolution of the source of particles formed in the collision of nuclei can be studied through particle correlations. The STAR experiment is dedicated to study ultra-relativistic heavy ions collisions and allows to measure non-identical strange particle correlations. The source size can be extracted by studying p - {Lambda}, {bar p} - {bar {Lambda}}, {bar p} - {Lambda} and p - {bar {Lambda}} correlation functions. Strong interaction potential has been studied for these systems using an analytical model. Final State Interaction (FSI) parameters have been determined and has shown a significant annihilation process present in {bar p} - {Lambda} and p - {bar {Lambda}} systems not present in p - {Lambda} and {bar p} - {bar {Lambda}}.

  20. Search for supersymetric particles desintegrant itself in R-parite violee (coupling lambda_121) in a final state has three leptons

    SciTech Connect

    Magnan, Anne-Marie

    2005-07-12

    This thesis is dedicated to the study of the first data taken by the D0 detector during the Run II of the Tevatron. Supersymmetric particles have been search for in proton-antiproton collisions, with a center of mass energy of 1.96 TeV. In the framework of supersymmetry with R-parity violation, I have studied the pair production of Gauginos, leading to a pair of LSP (Χ$0\\atop{1}$), each one decaying into eevμ or eμve with a λ121 coupling. The final state contains at least two electrons: I have thus paid special attention in this work to the methods concerning identification and mis-identification of electromagnetic particles, as well as reconstruction, triggering, and correction (of the reconstructed energy). In a selection of trileptons, with at least two electrons, and some transverse missing energy, we observed 0 event in the 350 pb-1 of analyzed data, for 0,4$+0,35\\atop{0,05}$(stat) ± 0,16 (sys) expected from the Standard Model contributions. In the signal considered in this analysis, the selection efficiency is around 12%. Results have been studied in two models: mSUGRA and MSSM. In mSUGRA model, limits on m1/2 and lightest gauginos's masses have been obtained, with tanβ = 5, A0 = 0, m0 = 100 and 1000 GeV.c-2 and both signs of μ. In MSSM, with the hypothesis of massive sfermions (1000 GeV.c-2), we can exclude, at 95% Confidence Level, the region mX1± < 200 GeV.c-2, for all masses of Χ$0\\atop{1}$ LSP.

  1. Lambda Polarization in Lead-Lead Collisions

    NASA Astrophysics Data System (ADS)

    Schillings, Eelco

    2003-05-01

    In this thesis the production and polarization of Lambda particles produced in Pb-Pb collisions at a beam energy of 158 GeV/c per nucleon are studied. In these collisions nuclear matter is compressed and heated and under these conditions it is possible that a quark-gluon plasma (QGP) is created. In a QGP the boundaries between individual particles disappear and the quarks and gluons can move around freely. One of the probes to study the creation of the QGP is the so-called Strangeness Enhancement, which is the enhanced production of strange particles, with respect to the production in proton-induced collisions. Another proposed signature of the QGP is the disappearance of transverse Lambda polarization around mid-rapidity. Transverse Lambda polarization can occur when the spin of the produced Lambda has its preferred direction perpendicular to the production plane. In proton-proton and proton-nucleus collisions a negative transverse polarization has been observed and its magnitude was largest for the Lambdas produced in the direction of the beam (i.e. at high xF). This is an indication that the projectile plays an important role and in semi-classical models the following picture is assumed: in the interaction region a spin-zero ud-diquark from the projectile recombines with a negatively polarized s-quark from the sea. This s-quark also gives transverse momentum (pT) to the Lambda and as a result the polarization is dependent on pT. Recently it has been shown that also in nucleus-nucleus collisions a negative transverse polarization occurs, so even in large interaction regions the information on the nature of the projectile is kept. In a QGP however this information is lost and no production plane can be defined. This will cause the transverse polarization of the Lambdas produced in this region to disappear. The transverse polarization of the produced Lambdas has been measured in the NA57 experiment at CERN around two values of xF: for xF = 0.09 a value of +0.6 +7

  2. Suppression of the {Lambda}-{Sigma} coupling in nuclear matter

    SciTech Connect

    Bodmer, A.R.; Usmani, Q.N.

    1995-08-01

    We initiated a study of the modification of the coupling of the {Lambda}N to the {Sigma}N channel in nuclear matter with the Fermi hypernetted-chain variational approach. This modification of the {Lambda}N-{Sigma}N coupling is a central problem in hypernuclear physics and is related closely to the strongly repulsive three-body forces which are needed to account for hypernuclear binding energies. All earlier calculations have only considered this problem in the so-called G-matrix approximation which neglects important higher-order effects. An important result of this work will be a better understanding of the density dependence of {Lambda} binding in nuclear matter, which can then be tested in the calculation of the {Lambda} single-particle energies.

  3. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

    PubMed Central

    Emanuel, B S; Cannizzaro, L A; Magrath, I; Tsujimoto, Y; Nowell, P C; Croce, C M

    1985-01-01

    We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda. Images PMID:3923432

  4. Lambda Hyperon and Anti-Lambda Hyperon Production in Proton-Antiproton Collisions at SQRT.S = 1.8 Tev

    NASA Astrophysics Data System (ADS)

    Wesson, Dennis Keith

    1990-01-01

    The characteristics of Lambda and |Lambda production have been studied from data obtained from p p collisions at sqrt{rm s} = 1.8 TeV during the first running period of experiment E735 from January to May of 1987. The experiment was conducted at the Fermi National Laboratory Tevatron collider. Five million triggers from an integrated luminosity of about 1over 3 nb^{ -1} were written to tape during this initial run of E735. Using a magnetic spectrometer arm a sample of 413 Lambda's + = Lambda's were found in these events. The transverse momentum spectrum, the ratio Lambda/(all charged particles) and the ratio Lambda/proton were studied from this sample. These were compared to the findings at lower energies and also to the results of a Monte Carlo program from another experiment. The average transverse momentum was found to be 0.77 +/- 0.06 +/- 0.08, an increase of about 24% from the value found at sqrt{rm s} = 540 GeV (CERN SPS) and an increase of about 55% from sqrt{rm s} = 53 GeV (CERN ISR). The Lambda/(all charged particle) ratio was also found to increase from 0.009 +/- 0.001 at sqrt{rm s} = 53 GeV (CERN ISR) and 0.019 +/- 0.004 at sqrt{rm s} = 540 GeV (CERN SPS), to 0.026 +/- 0.002 +/- 0.004 at our energy of sqrt{rm s} = 1.8 TeV. The lambda/proton ratio was found to be 0.38 +/- 0.03 +/- 0.06. This ratio shows no increase from lower energies. The lambda/proton ratio was used to find the strangeness suppression factor (lambda) from the quark combinatoric model of hadron production. We obtain a value lambda = 0.34 +/- 0.05 in agreement with the values found at lower energies. The increase in the ratio lambda/all charged particles as a function of center of mass energy is not inconsistent with the formation of quark-gluon plasma. However, the constant ratio of lambda/proton production is not expected in quark-gluon plasma production. Moreover, our data seem to agree with the UA5 Monte Carlo data, which does not include quark-gluon plasma production. Based on Lambda

  5. The flatness problem and Lambda.

    PubMed

    Lake, Kayll

    2005-05-27

    By way of a complete integration of the Friedmann equations, in terms of observables, it is shown that for the cosmological constant Lambda > 0 there exist nonflat Friedmann-Lemaître-Robertson-Walker models for which the total density parameter omega remains approximately 1 throughout the entire history of the Universe. Further, it is shown that in a precise quantitative sense these models are not finely tuned. When observations are brought to bear on the theory, and, in particular, the Wilkinson microwave anisotropy probe observations, they confirm that we live in just such a universe. The conclusion holds when the classical notion of Lambda is extended to dark energy.

  6. Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor.

    PubMed Central

    Frangione, B; Moloshok, T; Prelli, F; Solomon, A

    1985-01-01

    Serologic, structural, and genetic analyses have shown that the constant (C) region of human kappa light chains is encoded by a single gene, whereas that of lambda chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal lambda VI light chains, Bence Jones proteins Sut and Mor. The C region of lambda chains Sut and Mor consists of 105 residues, as is characteristic for human lambda light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C lambda isotype Mcg-, Kern-, Oz+ and represents a product of the C lambda 3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from lambda chains encoded by the C lambda 1 (Mcg+), C lambda 2 (Kern-, Oz-), and C lambda 3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C lambda genome. The gene encoding the C region sequence of lambda chain Mor is designated CMor lambda. PMID:3923477

  7. Lambda bacteriophage-mediated transduction of ColE1 deoxyribonucleic acid having a lambda bacteriophage-cohesive end site: selection of packageable-length deoxyribonucleic acid.

    PubMed Central

    Umene, K; Shimada, K; Tsuzuki, T; Mori, R; Takagi, Y

    1979-01-01

    An in vitro recombinant ColE1-cos lambda deoxyribonucleic acid (DNA) molecule, pKY96, has 70% of the length of lambda phage DNA. The process of lambda phage-mediated transduction of pKY96 generated a small amount of transducing phage particles containing ColE1-cos lambda DNA molecules of 80 or 101% of the length of lambda phage DNA, in addition to those containing original pKY96 DNA molecules. The newly isolated larger plasmid DNAs were transduced 100 times more efficiently than pKY96 DNA. Their structures were compared with that of a prototype pKY96 DNA, and the mechanism of the formation of these molecules is discussed. Images PMID:158007

  8. The Distribution of Crossovers along Unreplicated Lambda Bacteriophage Chromosomes

    PubMed Central

    Stahl, Franklin W.; McMilin, Kenneth D.; Stahl, Mary M.; Crasemann, Jean M.; Lam, Stephen

    1974-01-01

    The distribution of crossovers along unreplicated chromosomes of bacteriophage lambda has been examined by determining the density distributions and genotypes of particles in the progenies of crosses of density-labeled by ordinary parents in the presence of genetic blocks to replication. The Red and Rec systems combined produce crossovers primarily near the ends (especially the right end) of the chromosome. Removal of the generalized lambda recombination functions by red and gam mutations results in loss of these terminal crossovers; coupled with this loss is a disappearance of the differential dependence of recombination frequencies in terminal and central intervals on DNA synthesis. Removal of the bacterial system by a recA mutation results in severe depression of crossing over among unreplicated phage, with the few recombinants produced by the lambda system occurring near the right end. PMID:4416166

  9. Transfection of Escherichia coli spheroplasts: infectious lambda prophage DNA.

    PubMed

    Benzinger, R; Kleber, I; Huskey, R

    1978-06-01

    High mol. wt. DNA was extracted from Escherichia coli lambda lysogens and was shown to be infectious. Its infectivity was due to prophage DNA integrated into the host chromosome rather than to DNA released from mature phage particles, as established by the following criteria: the titre of infectious DNA exceeded by 100-fold the titre of infectious units present before DNA extraction; mild shear selectively reduced prophage DNA infectivity to 2% of the unsheared DNA while lambda phage DNA infectivity retained 50% of its infectivity; DNA extracted from an E. coli (lambda c857 tsxisam6) lysogen yielded 200 times as many plaques on sup+ than on sup- spheroplasts. Thus lambda prophage DNA infectivity depends on expression of the excision gene while the infectivity of non-integrated forms of lambda does not. About 10(4) genome equivalents of E. coli DNA yielded one infectious centre unit in this assay system; this high infectivity should make prophage DNA a useful marker in genetic transformation experiments.

  10. Longitudinal Polarization of {lambda} and {lambda}-bar Hyperons in Deep-Inelastic Scattering at COMPASS

    SciTech Connect

    Sapozhnikov, M. G.

    2007-06-13

    The longitudinal polarization of {lambda} and {lambda}-bar hyperons produced in deep-inelastic scattering of 160 GeV/c polarized positive muons is studied in the COMPASS (CERN NA58) experiment. Preliminary results on the longitudinal polarization of {lambda} and {lambda}-bar from data collected during the 2003 run are presented.

  11. {lambda}NN Three-Body Force due to Coherent {lambda}-{sigma} Coupling

    SciTech Connect

    Akaishi, Yoshinori; Myint, Khin Swe

    2008-04-29

    The overbinding problem of {sub {lambda}}{sup 5}He is solved by introducing a concept of coherent {lambda}-{sigma} coupling which is equivalent to a {lambda}NN three-body force. This three-body force is coherently enhanced in the 0{sup +} states of {sub {lambda}}{sup 4}H and {sub {lambda}}{sup 4}He. The 0{sup +}-1{sup +} splitting in these hypernuclei is mainly due to coherent {lambda}-{sigma} coupling and partly due to the {lambda}N spin-spin interaction. A {lambda}NN three-body potential is derived from the coupled-channel treatment. The origin of the repulsive and attractive nature of the three-body force is discussed. Coherent {lambda}-{sigma} coupling becomes more important in neutron-rich hypernuclei and especially in neutron-star matter at high densities. The possible existence of ''hyperheavy hydrogen'', {sub {lambda}}{sup 6}H, is suggested.

  12. Lambda-instability of Keplerian orbits

    NASA Astrophysics Data System (ADS)

    Dumin, Yurii

    Although the Lambda-term is commonly recognized to be of crucial importance for the large-scale (cosmological) dynamics, its influence can be appreciable also at much less scales, particularly, for the long-term evolution of Keplerian orbits. Such effects were studied in the recent years in a number of papers, e.g. [1, 2]; however this was done only under the assumption of static de Sitter asymptotics at infinity. A more realistic treatment of this problem should be based, evidently, on the nonstationary Friedmann-Robertson-Walker asymptotics, which is commonly accepted in modern cosmology; and such an approach was outlined in our earlier paper [3]. The present report is devoted to the results of numerical integration of the equations of motion of a test particle experiencing a gravitational field of the massive central body against the Lambda-background. Apart from the tiny secular effect of Hubble type, which is naturally expected and was already discussed before [4], we have found a strong instability, which can develop at certain values of the orbital parameters. The growth rate of this instability is much larger than the typical Hubble velocity, and it can eventually lead to disruption of the Keplerian orbit and injection of the test particle with a considerable velocity. From our point of view, the revealed phenomenon may have important astrophysical applications, particularly, for explanation of the very fast proper motions of some stars, anomalous interstellar separation in multiple systems, etc. References: 1. A. Balaguera-Antolínez, C.G. Böhmer, M. Nowakowski. Class. Quant. Grav., v.23, p.485 (2006). 2. V. Kagramanova, J. Kunz, C Lämmerzahl. Phys. Lett. B, v.634, p.465 (2006). 3. Yu.V. Dumin. Phys. Rev. Lett., v.98, p.059001 (2007). 4. Yu.V. Dumin. Proc. 11th Marcel Grossmann Meeting on General Relativity (World Sci., Singapore, 2008), p.1752.

  13. Little lambda, who made thee?

    PubMed

    Gottesman, Max E; Weisberg, Robert A

    2004-12-01

    The study of the bacteriophage lambda has been critical to the discipline of molecular biology. It was the source of key discoveries in the mechanisms of, among other processes, gene regulation, recombination, and transcription initiation and termination. We trace here the events surrounding these findings and draw on the recollections of the participants. We show how a particular atmosphere of interactions among creative scientists yielded spectacular insights into how living things work.

  14. Measurement of the Lambda(b) lifetime in the exclusive decay Lambda(b) ---> J / psi Lambda

    SciTech Connect

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; Alkhazov, G.; /Buenos Aires U. /Rio de Janeiro, CBPF /Rio de Janeiro State U. /Sao Paulo, IFT /Alberta U. /Simon Fraser U. /York U., Canada /McGill U. /Hefei, CUST /Andes U., Bogota /Charles U.

    2007-04-01

    We have measured the {lambda}{sub b} lifetime using the exclusive decay {lambda}{sub b}{yields}J/{psi}{lambda}, based on 1.2 fb{sup -1} of data collected with the D0 detector during 2002-2006. From 171 reconstructed {lambda}{sub b} decays, where the J/{psi} and {lambda} are identified via the decays J/{psi}{yields}{mu}{sup +}{mu}{sup -} and {lambda}{yields}p{pi}, we measured the {lambda}{sub b} lifetime to be {tau}({lambda}{sub b})=1.218{sub -0.115}{sup +0.130}(stat){+-}0.042(syst) ps. We also measured the B{sup 0} lifetime in the decay B{sup 0}{yields}J/{psi}({mu}{sup +}{mu}{sup -})K{sub S}{sup 0}({pi}{sup +}{pi}{sup -}) to be {tau}(B{sup 0})=1.501{sub -0.074}{sup +0.078}(stat){+-}0.050(syst) ps, yielding a lifetime ratio of {tau}({lambda}{sub b})/{tau}(B{sup 0})=0.811{sub -0.087}{sup +0.096}(stat){+-}0.034(syst = )

  15. Evidence for the Heavy Baryon Resonance State $\\Lambda_{b}^{\\ast0}$ Observed with the CDF II Detector, and Studies of New Particle Tracking Technologies Using the LANSCE Proton Beam

    SciTech Connect

    Palni, Prabhakar

    2014-05-01

    To discover and probe the properties of new particles, we need to collide highly energetic particles. The Tevatron at Fermilab has collided protons and anti-protons at very high energies. These collisions produce short lived and stable particles, some known and some previously unknown. The CDF detector is used to study the products of such collisions and discover new elementary particles. To study the interaction between high energy charged particles and the detector materials often requires development of new instruments. Thus this dissertation involves a measurement at a contemporary experiment and development of technologies for related future experiments that will build on the contemporary one.

  16. Variational Monte Carlo calculations for the binding energy of sub. Lambda. Lambda. sup 31 Si

    SciTech Connect

    Ahsan, M.H. ); Kaykobad, M. ); Ali, S. )

    1991-01-01

    The binding energy of the {Lambda}{Lambda} hypernucleus {sub {Lambda}{Lambda}}{sup 31}Si has been calculated variationally with a {sup 28}Si+{ital n}+{Lambda}+{Lambda} four-body model. The integrations have been carried out with the help of a Monte Carlo technique. Three different types of {Lambda}-{Lambda} and {Lambda}-{ital N} potentials have been used. {ital n}-{sup 28}Si and {Lambda}-{sup 28}Si potentials have been generated by folding the {ital N}-{ital N} and {Lambda}-{ital N} potentials into the harmonic-oscillator shell-model density distribution of {sup 28}Si. The calculated values of the binding energy for the three different potentials are 40.19, 46.30, and 39.90 MeV. These values are compared with the reported experimental value of 38.2{plus minus}6.3 MeV. The dependence of the binding energy on the depth of the {Lambda}-{Lambda} interaction has also been investigated.

  17. Measurement of the forward-backward asymmetry of $\\Lambda$ and $\\bar{\\Lambda}$ production in $p \\bar{p}$ collisions

    SciTech Connect

    Abazov, Victor Mukhamedovich

    2016-02-09

    Here, we study $\\Lambda$ and $\\bar{\\Lambda}$ production asymmetries in $p \\bar{p} \\rightarrow \\Lambda (\\bar{\\Lambda}) X$, $p \\bar{p} \\rightarrow J/\\psi \\Lambda (\\bar{\\Lambda}) X$, and $p \\bar{p} \\rightarrow \\mu^\\pm \\Lambda (\\bar{\\Lambda}) X$ events recorded by the D0 detector at the Fermilab Tevatron collider at $\\sqrt{s} = 1.96$ TeV. We find an excess of $\\Lambda$'s ($\\bar{\\Lambda}$'s) produced in the proton (antiproton) direction. This forward-backward asymmetry is measured as a function of rapidity. We confirm that the $\\bar{\\Lambda}/\\Lambda$ production ratio, measured by several experiments with various targets and a wide range of energies, is a universal function of "rapidity loss", i.e., the rapidity difference of the beam proton and the lambda.

  18. Measurement of the forward-backward asymmetry of $$\\Lambda$$ and $$\\bar{\\Lambda}$$ production in $$p \\bar{p}$$ collisions

    DOE PAGES

    Abazov, Victor Mukhamedovich

    2016-02-09

    Here, we studymore » $$\\Lambda$$ and $$\\bar{\\Lambda}$$ production asymmetries in $$p \\bar{p} \\rightarrow \\Lambda (\\bar{\\Lambda}) X$$, $$p \\bar{p} \\rightarrow J/\\psi \\Lambda (\\bar{\\Lambda}) X$$, and $$p \\bar{p} \\rightarrow \\mu^\\pm \\Lambda (\\bar{\\Lambda}) X$$ events recorded by the D0 detector at the Fermilab Tevatron collider at $$\\sqrt{s} = 1.96$$ TeV. We find an excess of $$\\Lambda$$'s ($$\\bar{\\Lambda}$$'s) produced in the proton (antiproton) direction. This forward-backward asymmetry is measured as a function of rapidity. We confirm that the $$\\bar{\\Lambda}/\\Lambda$$ production ratio, measured by several experiments with various targets and a wide range of energies, is a universal function of "rapidity loss", i.e., the rapidity difference of the beam proton and the lambda.« less

  19. Study of Lambda+(c) Cabibbo favored decays containing a Lambda baryon in the final state

    SciTech Connect

    Link, J.M.; Yager, P.M.; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN, Pavia /Rio de Janeiro, Pont. U. Catol. /Puerto Rico U., Mayaguez /South Carolina U. /Tennessee U. /Vanderbilt U. /Wisconsin U., Madison

    2005-05-01

    Using data from the FOCUS experiment (FNAL-E831), they study the decay of {Lambda}{sub c}{sup +} baryons into final states contain a {Lambda} hyperon. The branching fractions of {Lambda}{sub c}{sup +} into {Lambda}{pi}{sup +}, {Lambda}{pi}{sup +}{pi}{sup +}{pi}{sup -} and {Lambda}{bar K}{sup 0}K{sup +} relative to that into pK{sup -} {pi}{sup +} are measured to be 0.217 {+-} 0.013 {+-} 0.020, 0.508 {+-} 0.024 {+-} 0.024 and 0.142 {+-} 0.018 {+-} 0.022, respectively. New measurements are also reported. Further, an analysis of the subresonant structure for the {Lambda}{sub c}{sup +} {yields} {Lambda}{pi}{sup +}{pi}{sup +}{pi}{sup -} decay mode is presented.

  20. Recent developments in Lambda networking

    NASA Astrophysics Data System (ADS)

    de Laat, C.; Grosso, P.

    About 6 years ago the first baby-steps were made on opening up dark fiber and DWDM infrastructure for direct use by ISP's after the transformation of the old style Telecom sector into a market driven business. Since then Lambda workshops, community groups like GLIF and a number of experiments have led to many implementations of hybrid national research and education networks and lightpath-based circuit exchanges as pioneered by SURFnet in GigaPort and NetherLight in collaboration with StarLight in Chicago and Canarie in Canada. This article looks back on those developments, describes some current open issues and research developments and proposes a concept of terabit networking.

  1. Polarization of Lambda0 and anti-Lambda0 inclusively produced by 610-GeV/c Sigma- and 525-GeV/c proton beams

    SciTech Connect

    Sanchez-Lopez, J.L.; Nelson, K.D.; Engelfried, J.; Akgun, U.; Alkhazov, G.; Amaro-Reyes, J.; Atamantchouk, A.G.; Ayan, A.S.; Balatz, M.Y.; Blanco-Covarrubias, A.; Bondar, N.F.; /Ball State U. /Bogazici U. /Carnegie Mellon U. /Rio de Janeiro, CBPF /Fermilab /Serpukhov, IHEP /Beijing, Inst. High Energy Phys. /Moscow, ITEP /Heidelberg, Max Planck Inst. /Moscow State U. /St. Petersburg, INP

    2007-06-01

    We have measured the polarization of {Lambda}{sup 0} and {bar {Lambda}{sup 0}} inclusively produced by 610 GeV/c {Sigma}{sup -} and 525 GeV/c proton beams in the experiment SELEX during the 1996/7 fixed target run at Fermilab. The polarization was measured as a function of the {Lambda} longitudinal momentum fraction x{sub F} and transverse momentum p{sub t}. For the {Lambda}{sup 0} produced by {Sigma}{sup -} the polarization is increasing with x{sub F} , from slightly negative at x{sub F} {approx} 0 to about 15% at large x{sub F} ; it shows a non-monotonic behavior as a function of p{sub t}. For the proton beam, the {Lambda}{sup 0} polarization is negative and decreasing as a function of x{sub F} and p{sub t}. The {bar {Lambda}{sup 0}} polarization is compatible with 0 for both beam particles over the full kinematic range. The target dependence was examined but no statistically significant difference was found.

  2. Chebyshev acceleration for lambda mode calculations

    SciTech Connect

    Belchior, A. Jr.; Moreira, J.M.L. )

    1992-01-01

    Coordenadoria para Projetos Especals (COPESP) has been making an effort to develop a power distribution mapping system utilizing self-powered neutron detectors. The scheme adopted to estimate the power distribution is based on an expansion of lambda modes for a given reactor state. Two-dimensional lambda modes were obtained previously with a modified version of the CITATION code. The method was based on the orthogonality properties of the lambda modes. Several modes could be obtained, but the convergence was slow because of the lack of an appropriate accelerating scheme in the CITATION code for calculating lambda modes. This work presents the acceleration scheme implemented into the CITATION code to obtain lambda modes.

  3. Lambda waves and occipital generators.

    PubMed

    Tatum, William O; Ly, Reynold C; Sluzewska-Niedzwiedz, Monika; Shih, Jerry J

    2013-10-01

    The objective of this study was to identify the relationship between lambda waves (LWs) and other occipital waveforms, in a retrospective analysis of electroencephalograms (EEGs) of clinic and hospitalized patients at a single center. The LWs were correlated with α rhythm, photic driving, and positive occipital sharp transients of sleep (POSTS). A computer-generated cursor quantified amplitude and duration of POSTS and LWs (3 waveforms and both hemispheres). Fisher exact test was used for significance (P ≤ .05). A total of 116 patients were evaluated. Of 111 patients, with interpretable results, 74 (66.67%) had visual scanning during EEG, with 37 (50.0%) having LWs. The LWs (17.69 µV) were consistently smaller than POSTS (31.40 µV) despite similar morphology. Patients with an α rhythm of >8.5 Hz were strongly correlated with the presence of LWs (P < .0001), and those with LWs were strongly predictive of normal EEG (P = .001). Of the 37 patients, 27 (73.0%) with LWs had photic driving (P = .0496). No correlation was found between LWs and POSTS (P = .45). The presence of LWs and a low normal posterior dominant rhythm (PDR) suggests intact electrocerebral health. LWs and the photic driving response suggest similar generators but stimulus-specific networks. POSTS differ from LWs despite similar morphology, suggesting different network activation of occipital generators. LWs have clinical significance in excluding encephalopathy. Occipital generators are differentiated by state and stimulus-dependent network activation and not by location and morphology.

  4. A single particle energies

    SciTech Connect

    Bodmer, A.R. |; Usmani, Q.N.; Sami, M.

    1993-09-01

    We consider the binding energies of {Lambda} hypernuclei (HN), in particular the single-particle (s.p.) energy data, which have been obtained for a wide range of HN with mass numbers A {le} 89 and for orbital angular momenta {ell}{sub {Lambda}} {le} 4. We briefly review some of the relevant properties of A hypernuclei. These are nuclei {sub {Lambda}}{sup A}Z with baryon number A in which a single {Lambda} hyperon (baryon number = 1) is bound to an ordinary nucleus {sup A}Z consisting of A - 1 nucleons = Z protons + N neutrons. The {Lambda} hyperon is neutral, has spin 1/2, strangeness S = {minus}1, isospin I = O and a mass M{sub {Lambda}} = 1116 MeV/c{sup 2}. Although the {Lambda} interacts with a nucleon, its interaction is only about half as strong as that between two nucleons, and thus very roughly V{sub {Lambda}N} {approx} 0.5 V{sub NN}. As a result, the two-body {Lambda}N system is unbound, and the lightest bound HN is the three-body hypertriton {sub {Lambda}}{sup 3}H in which the {Lambda} is bound to a deuteron with the {Lambda}-d separation energy being only {approx} 0.1 MeV corresponding to an exponential tail of radius {approx} 15 fm! In strong interactions the strangeness S is of course conserved, and the {Lambda} is distinct from the nucleons. In a HN strangeness changes only in the weak decays of the {Lambda} which can decay either via ``free`` pionic decay {Lambda} {yields} N + {pi} or via induced decay {Lambda} + N {yields} N + N which is only possible in the presence of nucleons. Because of the small energy release the pionic decay is strongly suppressed in all but the lightest HN and the induced decay dominates. However, the weak decay lifetime {approx} 10{sup {minus}10}s is in fact close to the lifetime of a free {Lambda}. Since this is much longer than the strong interaction time {approx} 10{sup {minus}22}s we can ignore the weak interactions when considering the binding of HN, just as for ordinary nuclei.

  5. Azimuthal anisotropy of K(0)(S) and Lambda+Lambda production at midrapidity from Au+Au collisions at sqrt[s(NN)]=130 GeV.

    PubMed

    Adler, C; Ahammed, Z; Allgower, C; Amonett, J; Anderson, B D; Anderson, M; Averichev, G S; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bichsel, H; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Boucham, A; Brandin, A; Bravar, A; Cadman, R V; Caines, H; Calderón de la Barca Sánchez, M; Cardenas, A; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chaloupka, P; Chattopadhyay, S; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; Deng, W S; Derevschikov, A A; Didenko, L; Dietel, T; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Filimonov, K; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Grachov, O; Grigoriev, V; Guedon, M; Gushin, E; Hallman, T J; Hardtke, D; Harris, J W; Henry, T W; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Humanic, T J; Igo, G; Ishihara, A; Ivanshin, Yu I; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E G; Kaneta, M; Kaplan, M; Keane, D; Kiryluk, J; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Konstantinov, A S; Kopytine, M; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kunde, G J; Kunz, C L; Kutuev, R Kh; Kuznetsov, A A; Lakehal-Ayat, L; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; LoCurto, G; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Ludlam, T; Lynn, D; Ma, J; Majka, R; Margetis, S; Markert, C; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnick, Yu; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mitchell, J; Moiseenko, V A; Moore, C F; Morozov, V; de Moura, M M; Munhoz, M G; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potrebenikova, E; Prindle, D; Pruneau, C; Putschke, J; Rai, G; Rakness, G; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Rykov, V; Sakrejda, I; Salur, S; Sandweiss, J; Saulys, A C; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schüttauf, A; Schweda, K; Seger, J; Seliverstov, D; Seyboth, P; Shahaliev, E; Shestermanov, K E; Shimanskii, S S; Shvetcov, V S; Skoro, G; Smirnov, N; Snellings, R; Sorensen, P; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A P; Sugarbaker, E; Suire, C; Sumbera, M; Surrow, B; Symons, T J M; Szanto de Toledo, A; Szarwas, P; Tai, A; Takahashi, J; Tang, A H; Thomas, J H; Thompson, M; Tikhomirov, V; Tokarev, M; Tonjes, M B; Trainor, T A; Trentalange, S; Tribble, R E; Trofimov, V; Tsai, O; Ullrich, T; Underwood, D G; Van Buren, G; VanderMolen, A M; Vasilevski, I M; Vasiliev, A N; Vigdor, S E; Voloshin, S A; Wang, F; Ward, H; Watson, J W; Wells, R; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Wood, J; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, W M; Zoulkarneev, R; Zubarev, A N

    2002-09-23

    We report STAR results on the azimuthal anisotropy parameter v(2) for strange particles K(0)(S), Lambda, and Lambda at midrapidity in Au+Au collisions at sqrt[s(NN)]=130 GeV at the Relativistic Heavy Ion Collider. The value of v(2) as a function of transverse momentum, p(t), of the produced particle and collision centrality is presented for both particles up to p(t) approximately 3.0 GeV/c. A strong p(t) dependence in v(2) is observed up to 2.0 GeV/c. The v(2) measurement is compared with hydrodynamic model calculations. The physics implications of the p(t) integrated v(2) magnitude as a function of particle mass are also discussed.

  6. Bacteriophage lambda: early pioneer and still relevant

    PubMed Central

    Casjens, Sherwood R.; Hendrix, Roger W.

    2015-01-01

    Molecular genetic research on bacteriophage lambda carried out during its golden age from the mid 1950's to mid 1980's was critically important in the attainment of our current understanding of the sophisticated and complex mechanisms by which the expression of genes is controlled, of DNA virus assembly and of the molecular nature of lysogeny. The development of molecular cloning techniques, ironically instigated largely by phage lambda researchers, allowed many phage workers to switch their efforts to other biological systems. Nonetheless, since that time the ongoing study of lambda and its relatives have continued to give important new insights. In this review we give some relevant early history and describe recent developments in understanding the molecular biology of lambda's life cycle. PMID:25742714

  7. Bacteriophage lambda: Early pioneer and still relevant.

    PubMed

    Casjens, Sherwood R; Hendrix, Roger W

    2015-05-01

    Molecular genetic research on bacteriophage lambda carried out during its golden age from the mid-1950s to mid-1980s was critically important in the attainment of our current understanding of the sophisticated and complex mechanisms by which the expression of genes is controlled, of DNA virus assembly and of the molecular nature of lysogeny. The development of molecular cloning techniques, ironically instigated largely by phage lambda researchers, allowed many phage workers to switch their efforts to other biological systems. Nonetheless, since that time the ongoing study of lambda and its relatives has continued to give important new insights. In this review we give some relevant early history and describe recent developments in understanding the molecular biology of lambda's life cycle.

  8. {lambda}0 Polarization in Exclusive pp Reactions

    SciTech Connect

    Felix, J.

    2006-09-25

    Among all properties of baryons, the polarization they acquire when created from unpolarized p-nucleus collisions is the most recent discovered one; so far, the origin of this polarization remains unexplained in spite of the experimental evidences accumulated in the past thirty years. Up to these days, {lambda}0 is the most studied baryon for polarization, due to it is very easy to produce {lambda}0's at the energies of the principal high energy physics accelerators of the world. This article is a review of the experimental experience accumulated on the polarization of {lambda}0 in unpolarized exclusive pp collisions as function of xF, PT, and M({lambda}0K+) in the past fifteen years here at the Instituto de Fisica, Universidad de Guanajuato, inside Fermilab e690 and Brookhaven National Laboratory e766 collaborations.

  9. Variable cosmological term \\varLambda(t)

    NASA Astrophysics Data System (ADS)

    Socorro, J.; D'oleire, M.; Pimentel, Luis O.

    2015-11-01

    We present the case of time-varying cosmological term \\varLambda(t). The main idea arises by proposing that as in the cosmological constant case, the scalar potential is identified as V(φ)=2\\varLambda, with \\varLambda a constant, this identification should be kept even when the cosmological term has a temporal dependence, i.e., V(φ(t))=2\\varLambda(t). We use the Lagrangian formalism for a scalar field φ with standard kinetic energy and arbitrary potential V(φ) and apply this model to the Friedmann-Robertson-Walker (FRW) cosmology. Exact solutions of the field equations are obtained by a special ansatz to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  10. Calculation of two-dimensional lambda modes

    SciTech Connect

    Belchior, A. Jr. ); Moreira, J.M.L. )

    1991-01-01

    A system for on-line monitoring of power distribution in small reactors (known as MAP) is under development at COPESP-IPEN. Signals of self-powered neutron detectors are input to a program that estimates the power distribution as an expansion of lambda modes. The modal coefficients are obtained from a least-mean-squares technique adequate for real-time analysis. Three-dimensional lambda modes are synthesized out of one- and two-dimensional lambda modes. As a part of this project, a modification of a computer code was carried out in order to obtain the lambda modes. The results of this effort are summarized. The lambda modes are the solutions of the time-independent multigroup neutron diffusion equation, an eigenvalue equation. Normally, the computer codes produce the fundamental mode corresponding to the largest eigenvalue; their respective interpretations are neutron flux distribution and effective multiplication factor. For calculating higher order lambda modes it is usually necessary to eliminate the contribution of the lower modes from the fission source.

  11. Branching extremals of the functional of \\lambda-normed length

    NASA Astrophysics Data System (ADS)

    Il'yutko, D. P.

    2006-06-01

    Networks on \\lambda-normed planes are considered, that is, on normed planes for which the unit circle is a regular 2\\lambda-gon. A geometric criterion is given for an arbitrary tree to be extremal on the \\lambda-normed plane, where \\lambda\

  12. Study ofe+e- to Lambda anti-Lambda, Lambda anti-Sigma^0,Sigma^0 anti-Sigma^0 using Initial State Radiation with BaBar

    SciTech Connect

    Aubert, B.

    2007-09-14

    We study the e+e- --> Lambda anti-Lambda gamma, Lambda anti-Sigma0 gamma, Sigma0 anti-Sigma0 gamma processes using 230 fb-1 of integrated luminosity collected by the BaBar detector at e+e- center-of-mass energy of 10.58 GeV. From the analysis of the baryon-antibaryon mass spectra the cross sections for e+e- --> Lambda anti-Lambda, Lambda anti-Sigma0, Sigma0 anti-Sigma0 are measured in the dibaryon mass range from threshold up to 3 GeV/c{sup 2}. The ratio of electric and magnetic form factors, |G{sub E}/G{sub M}|, is measured for e+e- --> Lambda anti-Lambda, and limits on the relative phase between Lambda form factors are obtained. We also measure the J/psi --> Lambda anti-Lambda, Sigma0 anti-Sigma0 and psi(2S) --> Lambda anti-Lambda branching fractions.

  13. A quark model of {bar {Lambda}}{Lambda} production in {bar p}p interactions

    SciTech Connect

    Alberg, M.A. |; Henley, E.M.; Wilets, L.; Kunz, P.D.

    1993-12-31

    A quark model which includes both scalar and vector contributions to the reaction mechanism (SV quark model) is used in a DWBA calculation of {anti {Lambda}}{Lambda} production in {bar p}p interactions. Total and differential cross-sections, polarizations, depolarizations, and spin-correlation coefficients are computed for laboratory momenta from threshold to 1695 MeV/c. The free parameters of the calculation are the scalar and vector strengths, a quark cluster size parameter, and the parameters of the unknown {anti {Lambda}}{Lambda} potentials. Good agreement with experiment is found for constructive interference of the scalar and vector terms, and for {anti {Lambda}}{Lambda} potentials which differ from those suggested by several authors on the basis of SU(3) arguments. The fit to the data is better than that obtained by other quark models, which use only scalar or vector annihilation terms. The agreement with experiment is also better than that found in meson-exchange models. The recent suggestion [1] that measurement of the depolarization parameter D{sub nn} can be used to discriminate between meson-exchange and quark models is examined in detail. We conclude that a measurement of D{sub nn} will provide a test of which of these models, as presently constructed, is the more appropriate description of strangeness production in the {bar p}p {yields} {anti {Lambda}}{Lambda} reaction.

  14. Spectrum of class-M supergiants in the region lambda lambda 7000-6000 angstrom

    NASA Technical Reports Server (NTRS)

    Orlov, M. Y.; Rodriguez, M. H.; Shavrina, A. V.

    1973-01-01

    A general description is given of the spectrum of four M-supergiants in the region lambda lambda 7000-6000 A from high-dispersion spectrograms (6 A/mm). The equivalent widths of several hundred lines and depths of some molecular band heads were measured.

  15. Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties.

    PubMed Central

    Short, J M; Fernandez, J M; Sorge, J A; Huse, W D

    1988-01-01

    A lambda insertion type cDNA cloning vector, Lambda ZAP, has been constructed. In E. coli a phagemid, pBluescript SK(-), contained within the vector, can be excised by f1 or M13 helper phage. The excision process eliminates the need to subclone DNA inserts from the lambda phage into a plasmid by restriction digestion and ligation. This is possible because Lambda ZAP incorporates the signals for both initiation and termination of DNA synthesis from the f1 bacteriophage origin of replication (1). Six of 21 restriction sites in the excised pBluescript SK polylinker, contained within the NH2-portion of the lacZ gene, are unique in lambda ZAP. Coding sequences inserted into these restriction sites, in the appropriate reading frame, can be expressed from the lacZ promoter as fusion proteins. The features of this vector significantly increase the rate at which clones can be isolated and analyzed. The lambda ZAP vector was tested by the preparation of a chicken liver cDNA library and the isolation of actin clones by screening with oligonucleotide probes. Putative actin clones were excised from the lambda vector and identified by DNA sequencing. The ability of lambda ZAP to serve as a vector for the construction of cDNA expression libraries was determined by detecting fusion proteins from clones containing glucocerbrosidase cDNA's using rabbit IgG anti-glucocerbrosidase antibodies. Images PMID:2970625

  16. Binding energy of (Lambda)He-7 and test of charge symmetry breaking in the Lambda N interaction potential

    SciTech Connect

    Hashimoto, O; Honda, D; Kaneta, M; Kato, F; Kawama, D; Maruyama, N; Matsumura, A; Nakamura, S N; Nomura, H; Nonaka, K; Ohtani, A; Okayasu, Y; Osaka, M; Oyamada, M; Sumihama, M; Tamura, H; Baker, O K; Cole, L; Christy, M; Gueye, P; Keppel, C; Tang, L; Yuan, L; Acha, A; Baturin, P; Boeglin, W; Kramer, L; Markowitz, P; Pamela, P; Perez, N; Raue, B; Reinhold, J; Rivera, R; Kato, S; Sato, Y; Takahashi, T; Daniel, A; Hungerford, Ed V; Ispiryan, M; Kalantarians, N; Lan, K J; Li, Y; Miyoshi, T; Randeniya, S; Rodriguez, V M; Bosted, P; Carlini, R; Ent, R; Fenker, H; Gaskell, D; Jones, M; Mack, D; Roche, J; Smith, G; Tvaskis, V; Vulcan, W; Wood, S; Yan, C; Asaturyan, A; Asaturyan, R; Egiyan, K; Mkrtchyan, H; Margaryan, A; Navasardyan, T; Tadevosyan, V; Zamkochian, S; Hu, B; Song, Y; Luo, W; Androic, D; Furic, M; Petkovic, T; Seva, T; Ahmidouch, A; Danagoulian, S; Gasparian, A; Halkyard, R; Johnson, K; Simicevic, N; Wells, S; Niculescu, G; Niculescu, M I; Gan, L; Benmokhtar, F; Horn, T; Elassar, M; Gibson, E F

    2011-09-01

    The binding energy of 7LambdaHe has been obtained for the first time with reaction spectroscopy using the (e, e'K+) reaction at Jefferson Lab's Hall C. A comparison among the binding energies of the A = 7 T = l iso-triplet hypernuclei, 7LambdaHe, 7LambdaLi*and 7LambdaBe, is made and possible charge symmetry breaking (CSB) in the LambdaN potential is discussed. For 7LambdaHe and 7LambdaBe, the shifts in binding energies are opposite to those predicted by a recent cluster model calculation, which assumes that the unexplained part of the binding energy difference between 4LambdaH and 4LambdaHe, is due to the CSB of the LambdaN potential. Further examination of CSB in light hypernuclear systems is required both experimentally and theoretically.

  17. Nonlinear stability control and lambda-bifurcation

    SciTech Connect

    Erneux, T.; Reiss, E.L.; Magnan, J.F.; Jayakumar, P.K.

    1987-12-01

    Passive techniques for nonlinear stability control are presented for a model of fluidelastic instability. They employ the phenomena of lambda-bifurcation and a generalization of it. lambda-bifurcation occurs when a branch of flutter solutions bifurcates supercritically from a basic solution and terminates with an infinite period orbit at a branch of divergence solutions which bifurcates subcritically from the basic solution. The shape of the bifurcation diagram then resembles the greek letter lambda. When the system parameters are in the range where flutter occurs by lambda-bifurcation, then as the flow velocity increase the flutter amplitude also increases, but the frequencies of the oscillations decrease to zero. This diminishes the damaging effects of structural fatigue by flutter, and permits the flow speed to exceed the critical flutter speed. If generalized lambda-bifurcation occurs, then there is a jump transition from the flutter states to a divergence state with a substantially smaller amplitude, when the flow speed is sufficiently larger than the critical flutter speed.

  18. A Spectral Atlas of lambda Bootis Stars

    NASA Astrophysics Data System (ADS)

    Paunzen, E.; Heiter, U.

    2014-06-01

    Since the discovery of lambda Bootes stars, a permanent confusion about their classification can be found in literature. This group of non-magnetic, Population I, metal-poor A to F-type stars, has often been used as some sort of trash can for "exotic" and spectroscopically dubious objects. Some attempts have been made to establish a homogeneous group of stars which share the same common properties. Unfortunately, the flood of "new" information (e.g. UV and IR data) led again to a whole zoo of objects classified as lambda Bootes stars, which, however, are apparent non-members. To overcome this unsatisfying situation, a spectral atlas of well established lambda Bootes stars for the classical optical domain was compiled. It includes intermediate dispersion (40 and 120 Å mm^{-1}) spectra of three lambda Bootes, as well as appropriate MK standard stars. Furthermore, "suspicious" objects, such as shell and Field Horizontal Branch stars, have been considered in order to provide to classifiers a homogeneous reference. As a further step, a high resolution (8 Å mm^{-1}) spectrum of one "classical" lambda Bootes star in the same wavelength region (3800-4600 Å) is presented. In total, 55 lines can be used for this particular star to derive detailed abundances for nine heavy elements (Mg, Ca, Sc, Ti, Cr, Mn, Fe, Sr and Ba).

  19. Lambda Exonuclease Digestion of CGG Trinucleotide Repeats

    PubMed Central

    Conroy, R.S.; Koretsky, A.P.; Moreland, J.

    2011-01-01

    Fragile X syndrome and other triplet repeat diseases are characterized by an elongation of a repeating DNA triplet. The ensemble-averaged lambda exonuclease digestion rate of different substrates, including one with an elongated FMR1 gene containing 120 CGG repeats, was measured using absorption and fluorescence spectroscopy. Using magnetic tweezers sequence-dependent digestion rates and pausing was measured for individual lambda exonucleases. Within the triplet repeats a lower average and narrower distribution of rates and a higher frequency of pausing was observed. PMID:19562332

  20. Stochastic cellular fate decision making by multiple infecting lambda phage.

    PubMed

    Robb, Matthew L; Shahrezaei, Vahid

    2014-01-01

    Bacteriophage lambda is a classic system for the study of cellular decision making. Both experiments and mathematical models have demonstrated the importance of viral concentration in the lysis-lysogeny decision outcome in lambda phage. However, a recent experimental study using single cell and single phage resolution reported that cells with the same viral concentrations but different numbers of infecting phage (multiplicity of infection) can have markedly different rates of lysogeny. Thus the decision depends on not only viral concentration, but also directly on the number of infecting phage. Here, we attempt to provide a mechanistic explanation of these results using a simple stochastic model of the lambda phage genetic network. Several potential factors including intrinsic gene expression noise, spatial dynamics and cell-cycle effects are investigated. We find that interplay between the level of intrinsic noise and viral protein decision threshold is a major factor that produces dependence on multiplicity of infection. However, simulations suggest spatial segregation of phage particles does not play a significant role. Cellular image processing is used to re-analyse the original time-lapse movies from the recent study and it is found that higher numbers of infecting phage reduce the cell elongation rate. This could also contribute to the observed phenomena as cellular growth rate can affect transcription rates. Our model further predicts that rate of lysogeny is dependent on bacterial growth rate, which can be experimentally tested. Our study provides new insight on the mechanisms of individual phage decision making. More generally, our results are relevant for the understanding of gene-dosage compensation in cellular systems.

  1. Neutral kaon and lambda production in electron-positron annihilation at 29 GeV and the Z boson resonance

    SciTech Connect

    Fordham, C.S.

    1990-10-01

    The production of K{sup 0} and {Lambda} in the hadronization of q{bar q} events from e{sup +}e{sup {minus}} collisions at 29 GeV and the Z{sup 0} resonance is studied using the Mark II detector as upgraded for running at the Stanford Linear Collider. Hadronization processes cannot presently be calculated with Quantum Chromodynamics; instead, hadronization models must be used in comparisons with data. In these models, hadronization occurs at local energy scales of a few GeV, a level at which small differences in quark and diquark mass significantly affect the production of particles such as K{sup 0} and {Lambda}, the lightest neutral meson and baryon containing strange quarks. Their production and behavior in hadronic events is a test for the accuracy of our understanding of hadronization. Two-charged- particle decays of the K{sup 0} and {Lambda} are isolated within the hadronic event sample. The resulting distribution of K{sup 0} and {Lambda} are corrected for inefficiencies and generalized to include all K{sup 0} and {Lambda}. Various kinematic distributions of the strange particles are examined. These distributions include the momentum and scaled momentum of the particles. The kinematics of the particles with respect to the original quark direction are examined through the distributions of rapidity and momentum transverse to the thrust both in and out of the event plane. The dependence of K{sup 0} and {Lambda} production on the sphericity of the hadronic events is also examined. All these distributions show that the behavior of K{sup 0} and {Lambda} in hadronic events is consistent with the hadronization models.

  2. The Lambda Orionis association. [star cluster anomalies

    NASA Technical Reports Server (NTRS)

    Murdin, P.; Penston, M. V.

    1977-01-01

    The Lambda Orionis association has the photometric properties of a typical young cluster with an age of about 4 million yr. Its distance is 400 + or - 40 pc. Attention is drawn to the lack of a dense molecular cloud and associated infrared sources in this young grouping

  3. Three-dimensional implicit lambda methods

    NASA Technical Reports Server (NTRS)

    Napolitano, M.; Dadone, A.

    1983-01-01

    This paper derives the three dimensional lambda-formulation equations for a general orthogonal curvilinear coordinate system and provides various block-explicit and block-implicit methods for solving them, numerically. Three model problems, characterized by subsonic, supersonic and transonic flow conditions, are used to assess the reliability and compare the efficiency of the proposed methods.

  4. particles

    NASA Astrophysics Data System (ADS)

    Xia, Yu; Chen, Zhihong; Zhang, Zhengguo; Fang, Xiaoming; Liang, Guozheng

    2014-05-01

    We explore a facile and nontoxic hydrothermal route for synthesis of a Cu2ZnSnS4 nanocrystalline material by using l-cysteine as the sulfur source and ethylenediaminetetraacetic acid (EDTA) as the complexing agent. The effects of the amount of EDTA, the mole ratio of the three metal ions, and the hydrothermal temperature and time on the phase composition of the obtained product have been systematically investigated. The addition of EDTA and an excessive dose of ZnCl2 in the hydrothermal reaction system favor the generation of kesterite Cu2ZnSnS4. Pure kesterite Cu2ZnSnS4 has been synthesized at 180°C for 12 h from the reaction system containing 2 mmol of EDTA at 2:2:1 of Cu/Zn/Sn. It is confirmed by Raman spectroscopy that those binary and ternary phases are absent in the kesterite Cu2ZnSnS4 product. The kesterite Cu2ZnSnS4 material synthesized by the hydrothermal process consists of flower-like particles with 250 to 400 nm in size. It is revealed that the flower-like particles are assembled from single-crystal Cu2ZnSnS4 nanoflakes with ca. 20 nm in size. The band gap of the Cu2ZnSnS4 nanocrystalline material is estimated to be 1.55 eV. The films fabricated from the hierarchical Cu2ZnSnS4 particles exhibit fast photocurrent responses under intermittent visible-light irradiation, implying that they show potentials for use in solar cells and photocatalysis.

  5. The Hyperon {Lambda}(1405) in p+p reactions

    SciTech Connect

    Siebenson, Johannes

    2011-10-21

    We present an analysis of the hyperon {Lambda}(1405) for p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the High Acceptance Di-Electron Spectrometer (HADES). A {Lambda}(1405) signal could be reconstructed in both charged decay channels ({Lambda}(1405){yields}{Sigma}{sup {+-}}{pi}{sup {+-}}).

  6. Measurement of the Branching Fraction and Lambda-bar Polarization in B0 -> Lambda-par p pi-

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-08-03

    We present a measurement of the B{sup 0} {yields} {bar {Lambda}}p{pi}{sup -} branching fraction performed using the BABAR detector at the PEP-II asymmetric e{sup +}e{sup -} collider. Based on a sample of 467 x 10{sup 6} B{bar B} pairs we measure {Beta}(B{sup 0} {yields} {bar {Lambda}}p{pi}{sup -}) [3.07 {+-} 0.31(stat.) {+-} 0.23(syst.)] x 10{sup -6}. The measured differential spectrum as a function of the dibaryon invariant mass m({bar {Lambda}}p) shows a near-threshold enhancement similar to that observed in other baryonic B decays. We study the {bar {Lambda}} polarization as a function of {bar {Lambda}} energy in the B{sup 0} rest frame (E*{sub {bar {Lambda}}}) and compare it with theoretical expectations of fully longitudinally right-polarized {bar {Lambda}} at large E*{sub {bar {Lambda}}}.

  7. The lambda point experiment in microgravity

    NASA Technical Reports Server (NTRS)

    Lipa, J. A.

    1988-01-01

    The motivation and potential for performing very high resolution measurements of the heat capacity singularity at the lambda point of helium in microgravity conditions was briefly discussed. It is clear that tests extending deep into the asymptotic region can be performed, where the theoretical predictions take on their simplest form. This advantageous situation should lead to a major improvement in the understanding of the range of applicability of current theoretical ideas in this field. The lambda transition holds out the prospect of giving the maximum advance of any system, and with the application of cryogenic techniques, the potential of this system can be realized. The technology for the initial experiments is already developed, and results could be obtained in 1990.

  8. Five years of photometry of Lambda Andromedae

    NASA Technical Reports Server (NTRS)

    Boyd, R. W.; Eaton, J. A.; Hall, D. S.; Henry, G. W.; Genet, R. M.; Lovell, L. P.; Hopkins, J. L.; Sabia, J. D.; Krisciunas, K.; Chambliss, C. R.

    1983-01-01

    Photoelectric photometry of the bright variable RS CVn-type binary Lambda And obtained in 1977-78 and 1980-81 is presented and used, together with earlier photometry, to derive the photometric period and discuss the changing shape of the light curve. The best ephemeris for times of minimum light is 2443829.2 + 53.95 d E. Because times of minimum and maximum extending back to those of Calder in 1933-37 can be phased together properly, the principal dark region must have maintained its identity for almost 50 yr. Over the last five years the brightness range has been between 3.70 and 4.05 m. During 1980-81 shallow secondary minima developed at phases where maxima occurred in previous years. Lambda And remains the only well-established case of nonsynchronous rotation among the known RS CVn variables.

  9. The {Lambda}(1405) in Full QCD

    SciTech Connect

    Menadue, Benjamin J.; Kamleh, Waseem; Leinweber, Derek B.; Mahbub, M. Selim

    2011-12-14

    At 1405.1 MeV, the lowest-lying negative-parity state of the {Lambda} baryon lies surprising low. Indeed, this is lower than the lowest negative-parity state of the nucleon, even though the {Lambda}(1405) possesses a valence strange quark. However, previous Lattice QCD studies have been unable to identify such a low-lying state. Using the PACS-CS (2+1)-flavour full-QCD ensembles, available through the ILDG, we utilise a variational analysis with source and sink smearing to isolate this elusive state. We find three low-lying odd-parity states, and for the first time reproduce the correct level ordering with respect to the nearby scattering thresholds.

  10. AN EXPRESSION TEMPLATE AWARE LAMBDA FUNCTION

    SciTech Connect

    S. A. SMITH; J. STRIEGNITZ

    2000-09-19

    The authors show how the paradigms of lambda functions and expression templates fit together in order to provide a means to increase the expressiveness of existing STL algorithms. They demonstrate how the expression templates approach could be extended in order to work with built-in types. To be portable, their solution is based on the Portable Expression Template Engine (PETE), which is a framework that enables the development of expression template aware classes.

  11. Trivalent Iron Induced Gelation in Lambda-Carrageenan.

    PubMed

    Running, Cordelia A; Falshaw, Ruth; Janaswamy, Srinivas

    2012-03-01

    This communication reports gelation of lambda-carrageenan, for the first time, in the presence of trivalent iron ions. Kappa-, iota- and lambda-carrageenans are sulfated polysaccharides used extensively in food, pharmaceutical and medical applications. Kappa- and iota-carrageenans show gelation in the presence of mono- and di-valent ions, but lambda-carrageenan yields only viscous solutions. Our results show that gelation in lambda-carrageenan indeed is possible, but with trivalent ions. X-ray fiber diffraction patterns of iron (III)-lambda-carrageenan are characteristic of highly oriented and polycrystalline fibers containing well resolved Bragg reflections. The elastic modulus (G') of the product is far greater than the loss modulus (G") indicating the thermal stability of lambda-carrageenan in the presence of iron (III) ions. This novel finding has potential to expand lambda-carrageenan's current utility beyond a viscosifying agent.

  12. Trivalent Iron Induced Gelation in Lambda-Carrageenan

    PubMed Central

    Running, Cordelia A.; Falshaw, Ruth; Janaswamy, Srinivas

    2012-01-01

    This communication reports gelation of lambda-carrageenan, for the first time, in the presence of trivalent iron ions. Kappa-, iota- and lambda-carrageenans are sulfated polysaccharides used extensively in food, pharmaceutical and medical applications. Kappa- and iota-carrageenans show gelation in the presence of mono- and di-valent ions, but lambda-carrageenan yields only viscous solutions. Our results show that gelation in lambda-carrageenan indeed is possible, but with trivalent ions. X-ray fiber diffraction patterns of iron (III)-lambda-carrageenan are characteristic of highly oriented and polycrystalline fibers containing well resolved Bragg reflections. The elastic modulus (G') of the product is far greater than the loss modulus (G") indicating the thermal stability of lambda-carrageenan in the presence of iron (III) ions. This novel finding has potential to expand lambda-carrageenan’s current utility beyond a viscosifying agent. PMID:22408280

  13. Regulation of replication of lambda phage and lambda plasmid DNAs at low temperature.

    PubMed

    Gabig, M; Obuchowski, M; Srutkowska, S; Wegrzyn, G

    1998-06-01

    It was previously demonstrated that while lysogenic development of bacteriophage lambda in Escherichia coli proceeds normally at low temperature (20-25 degrees C), lytic development is blocked under these conditions owing to the increased stability of the phage CII protein. This effect was proposed to be responsible for the increased stimulation of the pE promoter, which interferes with expression of the replication genes, leading to inhibition of phage DNA synthesis. Here we demonstrate that the burst size of phage lambda cIb2, which is incapable of lysogenic development, increases gradually over the temperature range from 20 to 37 degrees C, while no phage progeny are observed at 20 degrees C. Contrary to previous reports, it is possible to demonstrate that pE promoter activation by CII may be more efficient at lower temperature. Using density-shift experiments, we found that phage DNA replication is completely blocked at 20 degrees C. Phage growth was also inhibited in cells overexpressing cII, which confirms that CII is responsible for inhibition of phage DNA replication. Unexpectedly, we found that replication of plasmids derived from bacteriophage lambda is neither inhibited at 20 degrees C nor in cells overexpressing cII. We propose a model to explanation the differences in replication observed between lambda phage and lambda plasmid DNA at low temperature.

  14. MASS FUNCTION PREDICTIONS BEYOND {Lambda}CDM

    SciTech Connect

    Bhattacharya, Suman; Lukic, Zarija; Habib, Salman; Heitmann, Katrin; White, Martin; Wagner, Christian

    2011-05-10

    The statistics of dark matter halos is an essential component of precision cosmology. The mass distribution of halos, as specified by the halo mass function, is a key input for several cosmological probes. The sizes of N-body simulations are now such that, for the most part, results need no longer be statistics-limited, but are still subject to various systematic uncertainties. Discrepancies in the results of simulation campaigns for the halo mass function remain in excess of statistical uncertainties and of roughly the same size as the error limits set by near-future observations; we investigate and discuss some of the reasons for these differences. Quantifying error sources and compensating for them as appropriate, we carry out a high-statistics study of dark matter halos from 67 N-body simulations to investigate the mass function and its evolution for a reference {Lambda}CDM cosmology and for a set of wCDM cosmologies. For the reference {Lambda}CDM cosmology (close to WMAP5), we quantify the breaking of universality in the form of the mass function as a function of redshift, finding an evolution of as much as 10% away from the universal form between redshifts z = 0 and z = 2. For cosmologies very close to this reference we provide a fitting formula to our results for the (evolving) {Lambda}CDM mass function over a mass range of 6 x 10{sup 11}-3 x 10{sup 15} M{sub sun} to an estimated accuracy of about 2%. The set of wCDM cosmologies is taken from the Coyote Universe simulation suite. The mass functions from this suite (which includes a {Lambda}CDM cosmology and others with w {approx_equal} -1) are described by the fitting formula for the reference {Lambda}CDM case at an accuracy level of 10%, but with clear systematic deviations. We argue that, as a consequence, fitting formulae based on a universal form for the mass function may have limited utility in high-precision cosmological applications.

  15. Differential Photoproduction Cross Sections of the Sigma0(1385), Lambda(1405), and Lambda(1520)

    SciTech Connect

    Moriya, Kei; Schumacher, Reinhard A.

    2013-10-01

    We report the exclusive photoproduction cross sections for the Sigma(1385), Lambda(1405), and Lambda(1520) in the reactions gamma + p -> K+ + Y* using the CLAS detector for energies from near the respective production thresholds up to a center-of-mass energy W of 2.85 GeV. The differential cross sections are integrated to give the total exclusive cross sections for each hyperon. Comparisons are made to current theoretical models based on the effective Lagrangian approach and fitted to previous data. The accuracy of these models is seen to vary widely. The cross sections for the Lambda(1405) region are strikingly different for the Sigma+pi-, Sigma0 pi0, and Sigma- pi+ decay channels, indicating the effect of isospin interference, especially at W values close to the threshold.

  16. The Differential Cross Section and Lambda Recoil Polarization From gamma d to K0 Lambda( p)

    NASA Astrophysics Data System (ADS)

    Compton, Nicholas

    Presented is the analysis of the differential cross section and Lambda recoil polarization from the reaction gammad → K0Lambda(p). This work measured these observables over beam energies from 0.90 GeV to 3.0 GeV. These measurements are the first in this channel to cover such a wide range of energies. The data were taken using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Laboratory (JLAB) along with a tagged photon beam. This analysis was completed by identifying events of interest that decayed into the final state topology of pi-pi+pi- p(p). Through conservation of energy and momentum, the K0, Lambda, and missing mass of the spectator proton were reconstructed. Utilizing the same analysis techniques, the observables were measured on two different experiments with good agreement. Photoproduction of strange mesons from the neutron are difficult to measure, consequently there are only a few measurements of this kind. Despite that, these reactions supply essential complementary data to those on the proton. The differential cross sections and the recoil polarization extracted, span the region where new nucleon resonances have been found from studies of the reaction gammap → K +Lambda. Comparisons between the K+Lambda and K0Lambda cross section demonstrate that possible interference terms near 1900 MeV are less pronounced in the latter. This unexpected result inspired a partial wave analyses (PWA) to be fitted to the data. The fit solution shows that this measurement fostered an improvement on the knowledge of observed resonance parameters, necessary to understanding these excited states. The study of nucleon resonances is a key motivating factor since the resonance masses can be calculated from the theory of the strong nuclear force, called quantum chromodynamics, or QCD.

  17. Measurement of transverse {lambda} and {lambda}-bar polarization at COMPASS

    SciTech Connect

    Ferrero, A.

    2007-06-13

    New data on hyperon polarization in semi-inclusive deep inelastic scattering have been collected by the COMPASS collaboration at CERN during the years 2002-2004, using a beam of longitudinally polarized muons of 160 GeV/c and a 6LiD target that can be polarized both longitudinally and transversely. The various combinations of beam and target polarizations allow for the study of a wide variety of hyperon polarization effects. Here we present preliminary results on the transverse polarization of {lambda} and {lambda}-bar produced both with unpolarized and transversely polarized deuteron targets.

  18. Measurement of the Lambda0b lifetime in the decay lambda0b--> J/psiLambda0 with the D0 detector.

    PubMed

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Agelou, M; Agram, J-L; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Anderson, S; Andrieu, B; Arnoud, Y; Askew, A; Asman, B; Atramentov, O; Autermann, C; Avila, C; Badaud, F; Baden, A; Baldin, B; Balm, P W; Banerjee, S; Barberis, E; Bargassa, P; Baringer, P; Barnes, C; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Bean, A; Beauceron, S; Begel, M; Bellavance, A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Binder, M; Black, K M; Blackler, I; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Blumenschein, U; Boehnlein, A; Boeriu, O; Bolton, T A; Borcherding, F; Borissov, G; Bos, K; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Burdin, S; Burnett, T H; Busato, E; Butler, J M; Bystricky, J; Carvalho, W; Casey, B C K; Cason, N M; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Chapin, D; Charles, F; Cheu, E; Chevalier, L; Cho, D K; Choi, S; Christiansen, T; Christofek, L; Claes, D; Clément, B; Clément, C; Coadou, Y; Cooke, M; Cooper, W E; Coppage, D; Corcoran, M; Coss, J; Cothenet, A; Cousinou, M-C; Crépé-Renaudin, S; Cristetiu, M; Cummings, M A C; Cutts, D; da Motta, H; Davies, B; Davies, G; Davis, G A; De, K; de Jong, P; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Dean, S; Déliot, F; Delsart, P A; Demarteau, M; Demina, R; Demine, P; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Doidge, M; Dong, H; Doulas, S; Duflot, L; Dugad, S R; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Edwards, T; Ellison, J; Elmsheuser, J; Eltzroth, J T; Elvira, V D; Eno, S; Ermolov, P; Eroshin, O V; Estrada, J; Evans, D; Evans, H; Evdokimov, A; Evdokimov, V N; Fast, J; Fatakia, S N; Feligioni, L; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Freeman, W; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Galyaev, E; Garcia, C; Garcia-Bellido, A; Gardner, J; Gavrilov, V; Gay, P; Gelé, D; Gelhaus, R; Genser, K; Gerber, C E; Gershtein, Y; Ginther, G; Golling, T; Gómez, B; Gounder, K; Goussiou, A; Grannis, P D; Greder, S; Greenlee, H; Greenwood, Z D; Gregores, E M; Gris, Ph; Grivaz, J-F; Groer, L; Grünendahl, S; Grünewald, M W; Gurzhiev, S N; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Hagopian, S; Hall, I; Hall, R E; Han, C; Han, L; Hanagaki, K; Harder, K; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hong, S J; Hooper, R; Houben, P; Hu, Y; Huang, J; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jain, V; Jakobs, K; Jenkins, A; Jesik, R; Johns, K; Johnson, M; Jonckheere, A; Jonsson, P; Jöstlein, H; Juste, A; Kado, M M; Käfer, D; Kahl, W; Kahn, S; Kajfasz, E; Kalinin, A M; Kalk, J; Karmanov, D; Kasper, J; Kau, D; Kehoe, R; Kermiche, S; Kesisoglou, S; Khanov, A; Kharchilava, A; Kharzheev, Y M; Kim, K H; Klima, B; Klute, M; Kohli, J M; Kopal, M; Korablev, V M; Kotcher, J; Kothari, B; Koubarovsky, A; Kozelov, A V; Kozminski, J; Krzywdzinski, S; Kuleshov, S; Kulik, Y; Kunori, S; Kupco, A; Kurca, T; Lager, S; Lahrichi, N; Landsberg, G; Lazoflores, J; Le Bihan, A-C; Lebrun, P; Lee, S W; Lee, W M; Leflat, A; Lehner, F; Leonidopoulos, C; Lewis, P; Li, J; Li, Q Z; Lima, J G R; Lincoln, D; Linn, S L; Linnemann, J; Lipaev, V V; Lipton, R; Lobo, L; Lobodenko, A; Lokajicek, M; Lounis, A; Lubatti, H J; Lueking, L; Lynker, M; Lyon, A L; Maciel, A K A; Madaras, R J; Mättig, P; Magerkurth, A; Magnan, A-M; Makovec, N; Mal, P K; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martens, M; Mattingly, S E K; Mayorov, A A; McCarthy, R; McCroskey, R; Meder, D; Melanson, H L; Melnitchouk, A; Merkin, M; Merritt, K W; Meyer, A; Miettinen, H; Mihalcea, D; Mitrevski, J; Mokhov, N; Molina, J; Mondal, N K; Montgomery, H E; Moore, R W; Muanza, G S; Mulders, M; Mutaf, Y D; Nagy, E; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Nelson, S; Neustroev, P; Noeding, C; Nomerotski, A; Novaes, S F; Nunnemann, T; Nurse, E; O'dell, V; O'Neil, D C; Oguri, V; Oliveira, N; Oshima, N; Otero Y Garzón, G J; Padley, P; Parashar, N; Park, J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Perea, P M; Perez, E; Peters, O; Pétroff, P; Petteni, M; Phaf, L; Piegaia, R; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pope, B G; da Silva, W L Prado; Prosper, H B; Protopopescu, S; Przybycien, M B; Qian, J; Quadt, A; Quinn, B; Rani, K J; Rapidis, P A; Ratoff, P N; Reay, N W; Reucroft, S; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Royon, C; Rubinov, P; Ruchti, R; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A; Savage, G; Sawyer, L; Scanlon, T; Schamberger, R D; Schellman, H; Schieferdecker, P; Schmitt, C; Schukin, A A; Schwartzman, A; Schwienhorst, R; Sengupta, S; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shephard, W D; Shpakov, D; Sidwell, R A; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smith, R P; Smolek, K; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Song, X; Song, Y; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Souza, M; Spurlock, B; Stanton, N R; Stark, J; Steele, J; Steinbrück, G; Stevenson, K; Stolin, V; Stone, A; Stoyanova, D A; Strandberg, J; Strang, M A; Strauss, M; Ströhmer, R; Strovink, M; Stutte, L; Sumowidagdo, S; Sznajder, A; Talby, M; Tamburello, P; Taylor, W; Telford, P; Temple, J; Tentindo-Repond, S; Thomas, E; Thooris, B; Tomoto, M; Toole, T; Torborg, J; Towers, S; Trefzger, T; Trincaz-Duvoid, S; Tuchming, B; Tully, C; Turcot, A S; Tuts, P M; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Seguier, F; Vlimant, J-R; Von Toerne, E; Vreeswijk, M; Vu Anh, T; Wahl, H D; Walker, R; Wang, L; Wang, Z-M; Warchol, J; Warsinsky, M; Watts, G; Wayne, M; Weber, M; Weerts, H; Wegner, M; Wermes, N; White, A; White, V; Whiteson, D; Wicke, D; Wijngaarden, D A; Wilson, G W; Wimpenny, S J; Wittlin, J; Wobisch, M; Womersley, J; Wood, D R; Wyatt, T R; Xu, Q; Xuan, N; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yen, Y; Yip, K; Youn, S W; Yu, J; Yurkewicz, A; Zabi, A; Zatserklyaniy, A; Zdrazil, M; Zeitnitz, C; Zhang, D; Zhang, X; Zhao, T; Zhao, Z; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zitoun, R; Zutshi, V; Zverev, E G; Zylberstejn, A

    2005-03-18

    We present measurements of the Lambda(0)(b) lifetime in the exclusive decay channel Lambda(0)(b)--> J/psiLambda(0), with J/psi--> mu(+)mu(-) and Lambda(0)--> ppi(-), the B0 lifetime in the decay B0-->J/psiK(0)(S) with J/psi--> mu(+)mu(-) and K(0)(S)-->pi(+)pi(-), and the ratio of these lifetimes. The analysis is based on approximately 250 pb(-1) of data recorded with the D0 detector in pp collisions at sqrt[s] = 1.96 TeV. The Lambda(0)(b) lifetime is determined to be tau(Lambda(0)(b)) = 1.22(+0.22)(-0.18)(stat) +/- 0.04(syst) ps, the B0 lifetime tau(B0) = 1.40(+0.11)(-0.10)(stat) +/- 0.03(syst) ps, and the ratio tau(Lambda(0)(b))/tau(B0) = 0.87(+0.17)(-0.14)(stat) +/- 0.03(syst). In contrast with previous measurements using semileptonic decays, this is the first determination of the Lambda(0)(b) lifetime based on a fully reconstructed decay channel.

  19. Rabi resonances in the {lambda} excitation scheme

    SciTech Connect

    Godone, Aldo; Micalizio, Salvatore; Levi, Filippo

    2002-12-01

    We consider the interaction of a three-level system with phase-modulated resonant fields in the {lambda} excitation scheme. We treat theoretically the case of a sinusoidal phase modulation, a phase step perturbation, and a stochastic phase modulation. The appearance of a Rabi resonance both in the spectrum of the optical transmitted signal (electromagnetically induced transparency) and in the spectrum of the microwave emission (coherent population trapping maser) is considered in detail. All the theoretical results are compared with the analogous ones reported for the two-level system and with our experimental observations obtained for the case of rubidium in a buffer gas.

  20. Nuclear physics with strange particles

    SciTech Connect

    Dover, C.B.

    1988-01-01

    Recent progress in the understanding of strange particle interactions with nuclear systems is reviewed. We discuss the relative merits of various reactions such as (K/sup -/, ..pi../sup +-/), (..pi../sup +/, K/sup +/), or (..gamma.., K/sup +/) for hypernuclear production. The structure of /sub ..lambda..//sup 13/C is analyzed in some detail, in order to illustrate the role of the ..lambda..N residual interaction and approximate dynamical symmetries in hypernuclear structure. Recent results on the single particle states of a ..lambda.. in heavy systems, as revealed by (..pi../sup +/, K/sup +/) reaction studies, are used to extract information on the density dependence and effective mass which characterize the ..lambda..-nucleus mean field. Finally, we develop the idea the K/sup +/-nucleus scattering at low energies is sensitive to the subtle ''swelling'' effects for nucleons bound in nuclei. 64 refs., 13 figs.

  1. Rare {Lambda}{sub b} decays in a quark model

    SciTech Connect

    Mott, L.; Roberts, W.

    2010-08-05

    Hadronic form factors for the rare weak transitions {Lambda}{sub b{yields}{Lambda}}{sup (*)} are calculated using a nonrelativistic quark model. The form factors obtained in this way are found to satisfy the relationships expecetd from the heavy quark effective theory. Differential decay rates and branching ratios are calculated for the dileptonic decays {Lambda}{sub b{yields}{Lambda}}{sup (*)}l{sup +}l{sup -}, for both ground state and excited daughter baryons. Inclusion of the long distance contributions from charmonium resonances significantly enhances the decay rates. Future work is outlined.

  2. Remarks on the generalized Tukey's lambda family of distributions

    SciTech Connect

    Lam, H.; Bowman, K.O.; Shenton, L.R.

    1980-01-01

    The family of curves generated by the mapping of the uniform density F/sup -1/(lambda) = ..cap alpha.. + ..beta..(lambda/sup ..gamma..delta/ - (1-lambda)/sup ..gamma../)/..gamma.., 0 < lambda < 1, is considered. Primary interest is the application of the above density to approximating theoretical distribution functions of test statistics such as S.D., skewness, and kurtosis under non-normality. Moments are straight forward to evaluate in terms of gamma functions, or polygamma functions in special cases. 1 figure, 8 tables. (RWR)

  3. Charge-symmetry breaking {Lambda}-nucleon interaction

    SciTech Connect

    Bodmer, A.R.; Murali, M.; Usmani, Q.N.

    1995-08-01

    Some time ago we showed that the charge-symmetry-breaking interaction, as obtained from the mass four hypernuclei ({sub {Lambda}}{sup 4}H, {sub {Lambda}}{sup 4}He), was spin-independent; a result which cannot be understood with the conventional meson-exchange models. The calculations of ({sub {Lambda}}{sup 4}H, {sub {Lambda}}{sup 4}He) are currently being extended to include noncentral nuclear and hypernuclear forces which could modify this result. At a more fundamental level we intend to study quark-structure contributions to the charge-symmetry-breaking interaction.

  4. Analysis of the {Lambda}{sub b{yields}{Lambda}}l{sup +}l{sup -} decay in QCD

    SciTech Connect

    Aliev, T. M.; Savci, M.; Azizi, K.

    2010-03-01

    Taking into account the {Lambda} baryon distribution amplitudes and the most general form of the interpolating current of the {Lambda}{sub b}, the semileptonic {Lambda}{sub b{yields}{Lambda}}l{sup +}l{sup -} transition is investigated in the framework of the light cone QCD sum rules. Sum rules for all 12 form factors responsible for the {Lambda}{sub b{yields}{Lambda}}l{sup +}l{sup -} decay are constructed. The obtained results for the form factors are used to compute the branching fraction. A comparison of the obtained results with the existing predictions of the heavy quark effective theory is presented. The results of the branching ratio shows the detectability of this channel at the Large Hadron Collider beauty in the near future is quite high.

  5. QCD factorization for {Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -}

    SciTech Connect

    Zhang Zhenhua; Guo Xinheng; Lue Gang

    2011-02-01

    We prove that in the limit m{sub b},m{sub c}{yields}{infinity}, with m{sub c}/m{sub b} fixed, factorization holds at order {alpha}{sub s} for the decay {Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -}. This proof is done in the infinite-momentum frame in which the momenta of {pi}, {Lambda}{sub c}, and {Lambda}{sub b} go to infinity. Our result is renormalization-scale- and scheme-independent at O({alpha}{sub s}). This is the same as the QCD factorization for B{yields}D{pi}.

  6. The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane.

    PubMed Central

    Oddershede, Lene; Dreyer, Jakob Kisbye; Grego, Sonia; Brown, Stanley; Berg-Sørensen, Kirstine

    2002-01-01

    Using optical tweezers and single particle tracking, we have revealed the motion of a single protein, the lambda-receptor, in the outer membrane of living Escherichia coli bacteria. We genetically modified the lambda-receptor placing a biotin on an extracellular site of the receptor in vivo. The efficiency of this in vivo biotinylation is very low, thus enabling the attachment of a streptavidin-coated bead binding specifically to a single biotinylated lambda-receptor. The bead was used as a handle for the optical tweezers and as a marker for the single particle tracking routine. We propose a model that allows extraction of the motion of the protein from measurements of the mobility of the bead-molecule complex; these results are equally applicable to analyze bead-protein complexes in other membrane systems. Within a domain of radius approximately 25 nm, the receptor diffuses with a diffusion constant of (1.5 +/- 1.0) x 10(-9) cm(2)/s and sits in a harmonic potential as if it were tethered by an elastic spring of spring constant of ~1.0 x 10(-2) pN/nm to the bacterial membrane. The purpose of the protein motion might be to facilitate transport of maltodextrins through the outer bacterial membrane. PMID:12496085

  7. Microscopic theory of the lambda transition

    SciTech Connect

    Toyoda, T.

    1982-06-01

    Starting with a microscopic hamiltonian for a many-boson system with a hardcore interaction, the grand potential of the system, which contains the order-parameter of the lambda transition as one of the thermodynamical variables, is derived by making use of the finite temperature loop expansion. The divergence difficulty caused by the hardcore interaction is circumvented by the conventional field theoretic perturbation renormalization such that the chemical potential is renormalized instead of the conventional mass renormalization. The grand potential obtained consists of the superfluid part and the finite temperature elementary excitation part. The elementary excitation energy spectrum shows the Goldstone boson mode, namely, the photon, for the zero external field. A non-vanishing external field destroys such a Goldstone boson mode by causing an energy gap at zero momentum. The chemical potential and the critical temperature are also obtained for the weak coupling case. It is shown how the Bose-Einstein condensation is affected by the hardcore interaction.

  8. Multidimensional Resonance Analysis of $\\Lambda^+_c \\to pK^- \\pi^+$

    SciTech Connect

    Fox, George Frederic

    1999-01-01

    The $\\Lambda^+_c \\to pK^- \\pi^+$ decay is the first baryon decay which opens itself up to a Dalitz plot type analysis. However, unlike the previous Dalitz analyses on charm mesons, the baryon analysis involves particles with non-zero spin, and thus we are no longer dealing with a simple two dimensional problem, but a five dimensional problem. Using conventional and Neural Network techniques we have optimized the significance of our $\\Lambda_c$ signal. Then we modeled our background and acceptance in five dimensions and used the Helicity Formalism outlined by Jacob and Wick [Jac 95] to model the signal density. Ultimately, we used MINUIT to optimize the 34 coeffcients needed to describe the decay.

  9. Experimental Investigation of Weak Non-Mesonic Decay of 10Be(Lambda)Hypernuclei at CEBAF

    SciTech Connect

    S. Majewski; L. Majling; A. Margaryan; L. Tang

    2005-08-05

    Hypernuclei are convenient laboratory to study the baryon-baryon weak interaction and associated effective Hamiltonian. The strangeness changing process, in which a Lambda hyperon converts to a neutron with a release up to 176 MeV, provides a clear signal for a conversion of an s-quark to a d-quark. We propose to perform a non-mesonic weak decay study of 10Be(Lambda)hypernuclei using the (e,eK) reaction. These investigations will fully utilize the unique parameters of the CEBAF CW electron beam and RF system and are enabled by (1) the use of new detector for alpha particles based on the recently developed RF timing technique with picosecond resolution and (2) the small angle and large acceptance kaon spectrometer-HKS in Hall C.

  10. K{sup 0} and {lambda} production in Ni+Ni collisions near threshold

    SciTech Connect

    Merschmeyer, M.; Herrmann, N.; Benabderrahmane, M. L.; Cordier, E.; Mangiarotti, A.; Pelte, D.; Xiao, Z. G.; Lopez, X.; Andronic, A.; Hartmann, O. N.; Hildenbrand, K. D.; Koczon, P.; Leifels, Y.; Reisdorf, W.; Schuettauf, A.; Bastid, N.; Crochet, P.; Barret, V.; Dupieux, P.

    2007-08-15

    New results concerning the production of neutral strange particles, K{sup 0} and {lambda} in Ni+Ni collisions at 1.93A GeV, measured with the FOPI detector at GSI Darmstadt, are presented. Rapidity density distributions and Boltzmann slope parameter distributions are measured in nearly the full phase space of the reaction. The observables are compared to existing K{sup +} and proton data. While the K{sup 0} data agree with previously reported K{sup +} measurements, the {lambda} distributions show a different behavior relative to that of protons. The strangeness balance and the production yield per participating nucleon as a function of the centrality of the reaction are discussed, for the first time at GSI Schwerionen Synchrotron (SIS) energies.

  11. Correlation between UV dose requirement for lambda bacteriophage induction and lambda repressor concentration.

    PubMed Central

    Baluch, J; Sussman, R

    1978-01-01

    Escherichia coli K-12 wild type and a uvrA mutant derivative were used to construct isogenic strains bearing one, two, three, or more phage lambda cI genomes and containing increasing concentration of lambda repressor as measured by in vitro operator DNA-binding assays. The survival and phage induction in response to UV irradiation were determined. In both strains, dose-response relationships were obtained as a function of the cellular repressor concentration. The uvrA lysogens required one-tenth the UV fluence of the wild-type counterparts for induction. Lysogenic strains containing plasmids that overproduce the lambdaind+ repressor and the same lysogens with plasmids overproducing the lambdaind- repressor displayed the same survival curves as the nonlysogenic parental strain; however, only the former produced infectious centers (at a frequency of 2 x 10(-3) to 5 x 10(-4) in response to radiation. PMID:353300

  12. Moderate-resolution spectral standards from lambda 5600 to lambda 9000

    NASA Technical Reports Server (NTRS)

    Allen, Lori E.; Strom, Karen M.

    1995-01-01

    We present a grid of stellar classification spectra of moderate resolution (R approximately 1500) in the range lambda lambda 5600-9000 A, compiled from high signal-to noise spectra of 275 stars, most in the open clusters Praesepe and M67. The grid covers dwarfs from types B8 through M5, giants from G8 through M7, and subgiants from F5 through K0. We catalog atomic and molecular absorption features useful for stellar classification, and demonstrate the use of luminosity-sensitive features to distinguish between late-type dwarf and giant stars. The entire database is made available in digital format on anonymous ftp and through the World Wide Web.

  13. High-resolution spectroscopy of Lambda16N by electroproduction.

    PubMed

    Cusanno, F; Urciuoli, G M; Acha, A; Ambrozewicz, P; Aniol, K A; Baturin, P; Bertin, P Y; Benaoum, H; Blomqvist, K I; Boeglin, W U; Breuer, H; Brindza, P; Bydzovský, P; Camsonne, A; Chang, C C; Chen, J-P; Choi, Seonho; Chudakov, E A; Cisbani, E; Colilli, S; Coman, L; Craver, B J; De Cataldo, G; de Jager, C W; De Leo, R; Deur, A P; Ferdi, C; Feuerbach, R J; Folts, E; Fratoni, R; Frullani, S; Garibaldi, F; Gayou, O; Giuliani, F; Gomez, J; Gricia, M; Hansen, J O; Hayes, D; Higinbotham, D W; Holmstrom, T K; Hyde, C E; Ibrahim, H F; Iodice, M; Jiang, X; Kaufman, L J; Kino, K; Kross, B; Lagamba, L; LeRose, J J; Lindgren, R A; Lucentini, M; Margaziotis, D J; Markowitz, P; Marrone, S; Meziani, Z E; McCormick, K; Michaels, R W; Millener, D J; Miyoshi, T; Moffit, B; Monaghan, P A; Moteabbed, M; Muñoz Camacho, C; Nanda, S; Nappi, E; Nelyubin, V V; Norum, B E; Okasyasu, Y; Paschke, K D; Perdrisat, C F; Piasetzky, E; Punjabi, V A; Qiang, Y; Raue, B; Reimer, P E; Reinhold, J; Reitz, B; Roche, R E; Rodriguez, V M; Saha, A; Santavenere, F; Sarty, A J; Segal, J; Shahinyan, A; Singh, J; Sirca, S; Snyder, R; Solvignon, P H; Sotona, M; Subedi, R; Sulkosky, V A; Suzuki, T; Ueno, H; Ulmer, P E; Veneroni, P; Voutier, E; Wojtsekhowski, B B; Zheng, X; Zorn, C

    2009-11-13

    An experimental study of the (16)O(e,e'K(+))(Lambda)(16)N reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e,e'K(+))Lambda, Sigma(0) exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76+/-0.16 MeV was obtained for (Lambda)(16)N with better precision than previous measurements on the mirror hypernucleus (Lambda)(16)O. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p(1/2) and p(3/2) hole states of the (15)N core nucleus.

  14. Simple model for lambda-doublet propensities in bimolecular reactions

    NASA Technical Reports Server (NTRS)

    Bronikowski, Michael J.; Zare, Richard N.

    1990-01-01

    A simple geometric model is presented to account for lambda-doublet propensities in bimolecular reactions A + BC - AB + C. It applies to reactions in which AB is formed in a pi state, and in which the unpaired molecular orbital responsible for lambda-doubling arises from breaking the B-C bond. The lambda-doublet population ratio is predicted to be 2:1 provided that: (1) the motion of A in the transition state determines the plane of rotation of AB; (2) the unpaired pi orbital lying initially along the B-C bond may be resolved into a projection onto the AB plane of rotation and a projection perpendicular to this plane; (3) there is no preferred geometry for dissociation of ABC. The 2:1 lambda-doublet ratio is the 'unconstrained dynamics prior' lambda-doublet distribution for such reactions.

  15. Phillips' Lambda function: Data summary and physical model

    NASA Astrophysics Data System (ADS)

    Irisov, V.; Plant, W.

    2016-03-01

    Measurements of Phillips' Lambda function describing the average length of breakers on the ocean per unit area at speed cb are summarized. An expression is developed that fits these data within reasonable bounds. A physical model for the Lambda function is derived based on the assumption that breaking occurs when the surface steepness exceeds a threshold value. The energy contained in the breaking region is related to the fifth power of the breaker speed, as Phillips showed, and from this the probability of finding a breaker with a speed cb may be determined from a simulation of the long-wave surface based on a linear superposition of Fourier components. This probability is directly related to the Lambda function so that a form for this function can be determined. The Lambda function so determined agrees in both shape and intensity with the fit to the measured Lambda functions.

  16. High Resolution Spectroscopy of 16N_Lambda by Electroproduction

    SciTech Connect

    Cusanno, Francesco; Urciuoli, Guido; Acha Quimper, Armando; Ambrozewicz, Pawel; Aniol, Konrad; Baturin, Pavlo; Bertin, Pierre; Benaoum, Hachemi; Blomqvist, Ingvar; Boeglin, Werner; Breuer, Herbert; Brindza, Paul; Bydzovsky, Petr; Camsonne, Alexandre; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chen, Jian-Ping; Choi, Seonho; Chudakov, Eugene; Cisbani, Evaristo; Colilli, Stefano; Coman, Luminita; Craver, Brandon; de Cataldo, Giacinto; De Jager, Cornelis; De Leo, Raffaele; Deur, Alexandre; Ferdi, Catherine; Feuerbach, Robert; Folts, Edward; Frullani, Salvatore; Garibaldi, Franco; Gayou, Olivier; Giuliani, Fausto; Gomez, Javier; Gricia, Massimo; Hansen, Jens-Ole; Hayes, David; Higinbotham, Douglas; Holmstrom, Timothy; Hyde, Charles; Ibrahim, Hassan; Iodice, Mauro; Jiang, Xiaodong; Kaufman, Lisa; Kino, Kouichi; Kross, Brian; Lagamba, Luigi; LeRose, John; Lindgren, Richard; Lucentini, Maurizio; Margaziotis, Demetrius; Markowitz, Pete; Marrone, Stefano; Meziani, Zein-Eddine; McCormick, Kathy; Michaels, Robert; Millener, D.; Miyoshi, Toshinobu; Moffit, Bryan; Monaghan, Peter; Moteabbed, Maryam; Munoz Camacho, Carlos; Nanda, Sirish; Nappi, E.; Nelyubin, Vladimir; Norum, Blaine; Okasyasu, Y.; Paschke, Kent; Perdrisat, Charles; Piasetzky, Eliazer; Punjabi, Vina; Qiang, Yi; Raue, Brian; Reimer, Paul; Reinhold, Joerg; Reitz, Bodo; Roche, Rikki; Rodriguez, Victor; Saha, Arunava; Santavenere, Fabio; Sarty, Adam; Segal, John; Shahinyan, Albert; Singh, Jaideep; Sirca, Simon; Snyder, Ryan; Solvignon, Patricia; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Subedi, Ramesh; Sulkosky, Vince; Sulkosky, Vincent; Sulkosky, Vince; Sulkosky, Vincent; Suzuki, Tomokazu; Ueno, Hiroaki; Ulmer, Paul; Veneroni, P.P.; Voutier, Eric; Wojtsekhowski, Bogdan; Zeng, X.; Zorn, Carl

    2009-01-01

    An experimental study of the 16O(e, e'K+)16N_Lambda reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e, e'K+)Lambda,Sigma_0 exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76 ± 0.16 MeV was obtained for 16N_Lambda with better precision than previous measurements on the mirror hypernucleus 16O_Lambda. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p1/2 and p3/2 hole states of the 15N core nucleus.

  17. A Precision Measurement of the Lambda_c Baryon Mass

    SciTech Connect

    Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Tisserand, V.; Zghiche, A.; Grauges, E.; Palano, A.; Pappagallo, M.; Pompili, A.; Chen, J.C.; Qi, N.D.; Rong, G.; Wang, P.; Zhu, Y.S.; Eigen, G.; Ofte, I.; Stugu, B. /Bergen U. /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /INFN, Ferrara /Frascati /Genoa U. /INFN, Genoa /Harvard U. /Heidelberg U. /Imperial Coll., London /Iowa U. /Iowa State U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /Milan U. /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /Naples U. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /Padua U. /INFN, Padua /Paris U., VI-VII /Pennsylvania U. /Perugia U. /INFN, Perugia /Pisa U. /INFN, Pisa /Prairie View A-M /Princeton U. /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /Stanford U., Phys. Dept. /SUNY, Stony Brook /Tennessee U. /Texas U. /Texas U., Dallas /Turin U. /INFN, Turin /Trieste U. /INFN, Trieste /Vanderbilt U. /Victoria U. /Warwick U. /Wisconsin U., Madison /Yale U.

    2005-07-06

    The {Lambda}{sub c}{sup +} baryon mass is measured using {Lambda}{sub c}{sup +} {yields} {Lambda}K{sub S}{sup 0}K{sup +} and {Lambda}{sub c}{sup +} {yields} {Sigma}{sup 0}K{sub S}{sup 0}K{sup +} decays reconstructed in 232 fb{sup -1} of data collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage ring. The {Lambda}{sub c}{sup +} mass is measured to be 2286.46 {+-} 0.14 MeV/c{sup 2}. The dominant systematic uncertainties arise from the amount of material in the tracking volume and from the magnetic field strength.

  18. Tertiary structure of human {Lambda}6 light chains.

    SciTech Connect

    Pokkuluri, P. R.; Solomon, A.; Weiss, D. T.; Stevens, F. J.; Schiffer, M.; Center for Mechanistic Biology and Biotechnology; Univ. of Tennessee Medical Center /Graduate School of Medicine

    1999-01-01

    AL amyloidosis is a disease process characterized by the pathologic deposition of monoclonal light chains in tissue. To date, only limited information has been obtained on the molecular features that render such light chains amyloidogenic. Although protein products of the major human V kappa and V lambda gene families have been identified in AL deposits, one particular subgroup--lambda 6--has been found to be preferentially associated with this disease. Notably, the variable region of lambda 6 proteins (V lambda 6) has distinctive primary structural features including the presence in the third framework region (FR3) of two additional amino acid residues that distinguish members of this subgroup from other types of light chains. However, the structural consequences of these alterations have not been elucidated. To determine if lambda 6 proteins possess unique tertiary structural features, as compared to light chains of other V lambda subgroups, we have obtained x-ray diffraction data on crystals prepared from two recombinant V lambda 6 molecules. These components, isolated from a bacterial expression system, were generated from lambda 6-related cDNAs cloned from bone marrow-derived plasma cells from a patient (Wil) who had documented AL amyloidosis and another (Jto) with multiple myeloma and tubular cast nephropathy, but no evident fibrillar deposits. The x-ray crystallographic analyses revealed that the two-residue insertion located between positions 68 and 69 (not between 66 and 67 as previously surmised) extended an existing loop region that effectively increased the surface area adjacent to the first complementarity determining region (CDR1). Further, an unusual interaction between the Arg 25 and Phe 2 residues commonly found in lambda 6 molecules was noted. However, the structures of V lambda 6 Wil and Jto also differed from each other, as evidenced by the presence in the latter of certain ionic and hydrophobic interactions that we posit increased protein

  19. Measurement of the production fraction times branching fraction $\\boldsymbol{ f(b\\to\\Lambda_{b})\\cdot \\mathcal{B}(\\Lambda_{b}\\to J/\\psi \\Lambda)}$

    SciTech Connect

    Abazov, Victor Mukhamedovich; Abbott, Braden Keim; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Alexeev, Guennadi D.; Alkhazov, Georgiy D.; Alton, Andrew K.; Alverson, George O.; Alves, Gilvan Augusto; Ancu, Lucian Stefan; /Nijmegen U. /Fermilab

    2011-05-01

    The {Lambda}{sub b}(udb) baryon is observed in the decay {Lambda}{sub b} {yields} J/{psi}{Lambda} using 6.1 fb{sup -1} of p{bar p} collisions collected with the D0 detector at {radical}s = 1.96 TeV. The production fraction multiplied by the branching fraction for this decay relative to that for the decay B{sup 0} {yields} J/{psi}K{sub s}{sup 0} is measured to be 0.345 {+-} 0.034 (stat.) {+-} 0.033 (syst.) {+-} 0.003 (PDG). Using the world average value of f(b {yields} B{sup 0}) {center_dot} {Beta}(B{sup 0} {yields} J/{psi}K{sub s}{sup 0}) = (1.74 {+-} 0.08) x 10{sup -5}, they obtain f(b {yields} {Lambda}{sub b}) {center_dot} {Beta}({Lambda}{sub b} {yields} J/{psi}{Lambda}) = (6.01 {+-} 0.60 (stat.) {+-} 0.58 (syst.) {+-} 0.28 (PDG)) x 10{sup -5}. This measurement represents an improvement in precision by about a factor of three with respect to the current world average.

  20. pp-bar->LAMBDA{sub c}LAMBDA-bar{sub c} within a Handbag Picture - Section and Spin Observables

    SciTech Connect

    Goritschnig, A. T.; Schweiger, W.; Kroll, P.

    2009-08-04

    We study the process pp-bar->LAMBDA{sub c}LAMBDA-bar{sub c} within the generalized parton picture. Our starting point is the double handbag diagram which factorizes into soft generalized parton distributions and a hard subprocess amplitude for uu-bar->cc-bar. Our cross-section predictions may become interesting in view of forthcoming experiments at FAIR in Darmstadt.

  1. The holin of bacteriophage lambda forms rings with large diameter.

    PubMed

    Savva, Christos G; Dewey, Jill S; Deaton, John; White, Rebecca L; Struck, Douglas K; Holzenburg, Andreas; Young, Rye

    2008-08-01

    Holins control the length of the infection cycle of tailed phages (the Caudovirales) by oligomerizing to form lethal holes in the cytoplasmic membrane at a time dictated by their primary structure. Nothing is currently known about the physical basis of their oligomerization or the structure of the oligomers formed by any known holin. Here we use electron microscopy and single-particle analysis to characterize structures formed by the bacteriophage lambda holin (S105) in vitro. In non-ionic or mild zwitterionic detergents, purified S105, but not the lysis-defective variant S105A52V, forms rings of at least two size classes, the most common having inner and outer diameters of 8.5 and 23 nm respectively, and containing approximately 72 S105 monomers. The height of these rings, 4 nm, closely matches the thickness of the lipid bilayer. The central channel is of unprecedented size for channels formed by integral membrane proteins, consistent with the non-specific nature of holin-mediated membrane permeabilization. S105 present in detergent-solubilized rings and in inverted membrane vesicles showed similar sensitivities to proteolysis and cysteine-specific modification, suggesting that the rings are representative of the lethal holes formed by S105 to terminate the infection cycle and initiate lysis.

  2. Exclusive semileptonic decays of {lambda}{sub b}{yields}{lambda}l{sup +}l{sup -} in supersymmetric theories

    SciTech Connect

    Aslam, M. Jamil; Wang Yuming; Lue Caidian

    2008-12-01

    The weak decays of {lambda}{sub b}{yields}{lambda}l{sup +}l{sup -} (l=e, {mu}) are investigated in the minimal supersymmetric standard model (MSSM) and also in supersymmetric (SUSY) SO(10) grand unified models. In the MSSM special attention is paid to the neutral Higgs bosons (NHBs) as they make quite a large contribution in exclusive B{yields}X{sub s}l{sup +}l{sup -} decays at large tan{beta} regions of parameter space of SUSY models, since part of SUSY contributions is proportional to tan{sup 3}{beta}. The analysis of decay rate, forward-backward asymmetries, lepton polarization asymmetries, and the polarization asymmetries of the {lambda} baryon in {lambda}{sub b}{yields}{lambda}l{sup +}l{sup -} show that the values of these physical observables are greatly modified by the effects of NHBs. In the SUSY SO(10) grand unified theory model, the new physics contribution comes from the operators which are induced by the NHBs' penguins and also from the operators having chirality opposite to that of the corresponding standard model (SM) operators. SUSY SO(10) effects show up only in the decay {lambda}{sub b}{yields}{lambda}+{tau}{sup +}{tau}{sup -} where the longitudinal and transverse lepton polarization asymmetries deviate significantly from the SM value while the effects in the decay rate, forward-backward asymmetries, and polarization asymmetries of final state {lambda} baryon are very mild. The transverse lepton polarization asymmetry in {lambda}{sub b}{yields}{lambda}+{tau}{sup +}{tau}{sup -} is almost zero in the SM and in the MSSM model. However, it can reach to -0.1 in the SUSY SO(10) grand unified theory model and could be seen at the future colliders; hence this asymmetry observable will provide us useful information to probe new physics and discriminate between different models.

  3. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats

    PubMed Central

    Elhalwagy, Manal EA; Abd-Alrahman, Sherif H; Nahas, AA; Ziada, Reem M; Mohamady, Aziza H

    2015-01-01

    Background: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. Methods: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas’s examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods. Results: In addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups. Conclusions: In conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters. PMID:26221269

  4. The Structure and Function of the DNA from Bacteriophage Lambda

    PubMed Central

    Hogness, David S.

    1966-01-01

    The position and orientation of genes in lambda and lambda dg DNA are described. The position of six genes located in the right half of isolated lambda DNA was found to be -(N, iλ)--O-P---Q-R-(right end of DNA), which is their order on the genetic map of the vegetative phage. The order of the three genes of the galactose operon (k, t, and e) located in the left half of lambda dg DNA was found to be (left end of DNA)----k-t-e-, consistent with Campbell's model (5) for the formation of this variant. Gene orientation, defined as the direction of transcription along the DNA, is inferred to be from right to left for the galactose operon in lambda dg DNA. The strand of lambda DNA which functions as template in transcription of N, an "early" gene required for normal replication of lambda DNA, was determined as a first step in ascertaining the orientation of this gene. The method includes isolation of each strand, formation of each of two heteroduplex molecules consisting of one strand from wild-type and one from an N mutant) and comparison of their N activities. The second step, which consists of ascertaining the 5'-to-3' direction of each strand, is discussed, as is a determination of the orientation of gene R. PMID:5967430

  5. Lambda Probe Measurements of Laboratory Spheromaks

    NASA Astrophysics Data System (ADS)

    Jorne, E.; Bellan, P. M.; Hsu, S. C.; Moynihan, C.

    2003-10-01

    A combined current and magnetic probe (lambda probe) has been constructed and is being tested for the purpose of investigating the behavior of spheromaks formed by the Caltech planar spheromak gun. The probe consists of a 1.5cm diameter, 52 turn Rogowski coil and a single loop magnetic coil, housed in a ceramic shell attached to a 95cm long hollow, steel shaft. A high voltage power supply was used to test the probe's ability to measure pulsed currents with submicrosecond rise times. A calibrated current pulse was provided by a 1μF capacitor discharged by a krytron switch to a low inductance circuit. Magnetic calibration was obtained by using the capacitor bank to power a 16cm diameter Helmholtz coil. Both magnetic and current calibration were in good agreement with estimates based on geometry. An existing steel shaft will be replaced by a ceramic shaft in order to minimize undesired effects on the plasma by a conductor. Once sealed with epoxy, the probe will be ready for insertion into the vacuum chamber and used to measure the magnetic field and parallel current during spheromak formation.

  6. The control of lambda DNA terminase synthesis.

    PubMed Central

    Murialdo, H; Davidson, A; Chow, S; Gold, M

    1987-01-01

    Nu1 and A, the genes coding for bacteriophage lambda DNA terminase, rank among the most poorly translated genes expressed in E. coli. To understand the reason for this low level of translation the genes were cloned into plasmids and their expression measured. In addition, the wild type DNA sequences immediately preceding the genes were reduced and modified. It was found that the elements that control translation are contained in the 100 base pairs upstream from the initiation codon. Interchanging these upstream sequences with those of an efficiently translated gene dramatically increased the translation of terminase subunits. It seems unlikely that the rare codons present in the genes, and any feature of their mRNA secondary structure play a role in the control of their translation. The elimination of cos from plasmids containing Nu1 and A also resulted in an increase in terminase production. This result suggests a role for cos in the control of late gene expression. The terminase subunit overproducer strains are potentially very useful for the design of improved DNA packaging and cosmid mapping techniques. Images PMID:3029667

  7. High resolution spectroscopy of (lambda)(12)B by electroproduction.

    PubMed

    Iodice, M; Cusanno, F; Acha, A; Ambrozewicz, P; Aniol, K A; Baturin, P; Bertin, P Y; Benaoum, H; Blomqvist, K I; Boeglin, W U; Breuer, H; Brindza, P; Bydzovský, P; Camsonne, A; Chang, C C; Chen, J-P; Choi, Seonho; Chudakov, E A; Cisbani, E; Colilli, S; Coman, L; Craver, B J; De Cataldo, G; de Jager, C W; De Leo, R; Deur, A P; Ferdi, C; Feuerbach, R J; Folts, E; Fratoni, R; Frullani, S; Garibaldi, F; Gayou, O; Giulani, F; Gomez, J; Gricia, M; Hansen, J O; Hayes, D; Higinbotham, D W; Holmstrom, T K; Hyde, C E; Ibrahim, H F; Jiang, X; Kaufman, L J; Kino, K; Kross, B; Lagamba, L; LeRose, J J; Lindgren, R A; Lucentini, M; Margaziotis, D J; Markowitz, P; Marrone, S; Meziani, Z E; McCormick, K; Michaels, R W; Millener, D J; Miyoshi, T; Moffit, B; Monaghan, P A; Moteabbed, M; Muñoz Camacho, C; Nanda, S; Nappi, E; Nelyubin, V V; Norum, B E; Okasyasu, Y; Paschke, K D; Perdrisat, C F; Piasetzky, E; Punjabi, V A; Qiang, Y; Raue, B; Reimer, P E; Reinhold, J; Reitz, B; Roche, R E; Rodriguez, V M; Saha, A; Santavenere, F; Sarty, A J; Segal, J; Shahinyan, A; Singh, J; Sirca, S; Snyder, R; Solvignon, P H; Sotona, M; Subedi, R; Sulkosky, V A; Suzuki, T; Ueno, H; Ulmer, P E; Urciuoli, G M; Veneroni, P; Voutier, E; Wojtsekhowski, B B; Ye, Y; Zheng, X; Zhou, S; Zorn, C

    2007-08-03

    An experiment measuring electroproduction of hypernuclei has been performed in hall A at Jefferson Lab on a 12C target. In order to increase counting rates and provide unambiguous kaon identification two superconducting septum magnets and a ring imaging Cherenkov detector were added to the hall A standard equipment. An unprecedented energy resolution of less than 700 keV FWHM has been achieved. Thus, the observed (Lambda)(12)B spectrum shows for the first time identifiable strength in the core-excited region between the ground-state s-wave Lambda peak and the 11 MeV p-wave Lambda peak.

  8. Hierarchy of N-point functions in the {Lambda}CDM and ReBEL cosmologies

    SciTech Connect

    Hellwing, Wojciech A.; Juszkiewicz, Roman; Weygaert, Rien van de

    2010-11-15

    In this work we investigate higher-order statistics for the {Lambda}CDM and ReBEL scalar-interacting dark matter models by analyzing 180h{sup -1} Mpc dark matter N-body simulation ensembles. The N-point correlation functions and the related hierarchical amplitudes, such as skewness and kurtosis, are computed using the counts-in-cells method. Our studies demonstrate that the hierarchical amplitudes S{sub n} of the scalar-interacting dark matter model significantly deviate from the values in the {Lambda}CDM cosmology on scales comparable and smaller than the screening length r{sub s} of a given scalar-interacting model. The corresponding additional forces that enhance the total attractive force exerted on dark matter particles at galaxy scales lower the values of the hierarchical amplitudes S{sub n}. We conclude that hypothetical additional exotic interactions in the dark matter sector should leave detectable markers in the higher-order correlation statistics of the density field. We focused in detail on the redshift evolution of the dark matter field's skewness and kurtosis. From this investigation we find that the deviations from the canonical {Lambda}CDM model introduced by the presence of the 'fifth' force attain a maximum value at redshifts 0.5

  9. Observation of the Baryonic B decay B0bar to Lambda_c^+ anti-Lambda K-

    SciTech Connect

    Lees, J.P.; Poireau, V.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Milanes, D.A.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Koch, H.; Schroeder, T.; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U., Comp. Sci. Dept. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /INFN, Milan /Milan U. /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /Padua U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /INFN, Padua /INFN, Padua /Padua U. /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /Sassari U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-11-08

    The authors report the observation of the baryonic B decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +} {bar {Lambda}}K{sup -} with a significance larger than 7 standard deviations based on 471 x 10{sup 6} B{bar B} pairs collected with the BABAR detector at the PEP-II storage ring at SLAC. They measure the branching fraction for the decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +} {bar {Lambda}}K{sup -} to be (3.8 {+-} 0.8{sub stat} {+-} 0.2{sub sys} {+-} 1.0 {sub {Lambda}{sub c}{sup +}}) x 10{sup -5}. The uncertainties are statistical, systematic, and due to the uncertainty in the {Lambda}{sub c}{sup +} branching fraction. They find that the {Lambda}{sub c}{sup +} K{sup -} invariant mass distribution shows an enhancement above 3.5 GeV/c{sup 2}.

  10. Acquisition of a determinant for chloramphenicol resistance by coliphage lambda.

    PubMed Central

    Gottesman, M M; Rosner, J L

    1975-01-01

    A determinanat for chloramphenicol resistance, cam, initially detected on a resistance transfer factor (RTF) and since transferred to phage P1, may be acquired from P1 by coliphage lambda. Lambdapcam are obtained when a lambda prophage is induced in bacteria which also harbor P1 cam prophage. Lambdacam formation is not dependent upon host Rec or lambda Red recombination functions. Electron microscopic heteroduplex analysis shows that the cam locus in two lambdapcams is a 5% addition of DNA in the b2 region of lambda, not contiguous with att. The extent and nucloetide sequence of the DNA insertion in the two independent lambdapcam isolates appear to be the same though they are located at different sites within the b2 region. We conclude that the determinant for chloramphenicol resistance is contained on a unique piece of DNA which facilitates its insertion into a number of unrelated genomes. Images PMID:1061090

  11. Search for e{sup +}e{sup -}{yields}{lambda}{sub b}{sup 0}{lambda}{sub b}{sup 0} near threshold

    SciTech Connect

    Besson, D.; Pedlar, T.K.; Cronin-Hennessy, D.

    2005-01-01

    Using the CLEO-III detector at CESR we study e{sup +}e{sup -} collisions in the center-of-mass energy close to, or above, {lambda}{sub b}{sup 0}{lambda}{sub b}{sup 0} production threshold. We search for evidence of {lambda}{sub b}{sup 0}{lambda}{sub b}{sup 0} resonance production and set upper limits based on inclusive hadron production as a barometer of {lambda}{sub b}{sup 0}{lambda}{sub b}{sup 0} production.

  12. ClpP/ClpX-mediated degradation of the bacteriophage lambda O protein and regulation of lambda phage and lambda plasmid replication.

    PubMed

    Wegrzyn, A; Czyz, A; Gabig, M; Wegrzyn, G

    2000-01-01

    The O protein is a replication initiator that binds to the orilambda region and promotes assembly of the bacteriophage lambda replication complex. This protein, although protected from proteases by other elements of the replication complex, in a free form is rapidly degraded in the host, Escherichia coli, by the ClpP/ClpX protease. Nevertheless, the physiological role of this rapid degradation remains unclear. Here we demonstrate that the copy number of plasmids derived from bacteriophage lambda is significantly higher in wild-type cells growing in rich media than in slowly growing bacteria. However, lambda plasmid copy number in bacteria devoid of the ClpP/ClpX protease was not dependent on the bacterial growth rate and in all minimal media tested was comparable to that observed in wildtype cells growing in a rich medium. Contrary to lambda plasmid replication, the efficiency of lytic growth of bacteriophage lambda was found to be dependent on the host growth rate in both wild-type bacteria and clpP and clpX mutants. The activities of two major lambda promoters operating during the lytic development, p(R) and p(L), were found to be slightly dependent on the host growth rate. However, when p(R) activity was significantly decreased in the dnaA mutant, production of phage progeny was completely abolished at low growth rates. These results indicate that the O protein (whose level in E. coli cells depends on the activity of ClpP/ClpX protease) is a major limiting factor in the regulation of lambda plasmid replication at low bacterial growth rates. However, this protein seems to be only one of the limiting factors in the bacteriophage lambda lytic development under poor growth conditions of host cells. Therefore, it seems that the role of the rapid ClpP/ClpX-mediated proteolysis of the O protein is to decrease the efficiency of early DNA replication of the phage in slowly growing host cells.

  13. The multiplicity and the spectra of secondaries correlated with the leading particle energy

    NASA Technical Reports Server (NTRS)

    Kruglov, N. A.; Proskuryakov, A. S.; Sarycheva, L. I.; Smirnova, L. N.

    1985-01-01

    The spectra of leading particles of different nature in pp-collisions at E sub 0 = 33 GeV are obtained. The multiplicities and the spectra of secondaries, mesons, gamma-quanta, lambda and lambda-hyperons and protons for different leading particle energy ranges are determined.

  14. Formation of oligomeric structures from plasmid DNA carrying cos lambda that is packaged into bacteriophage lambda heads.

    PubMed Central

    Miwa, T; Matsubara, K

    1983-01-01

    Plasmids that carry cos lambda, the region necessary for lambda phage packaging and that are as small as four kilobases in size can be packaged into lambda phage heads in head-to-tail tandem oligomeric structures. Multimeric oligomers as large as undecamers have been detected. Oligomer formation depends upon the products of red and gam of lambda, and the general recombination occurs between different plasmids that share homologous DNA regions. The packaging efficiency of plasmids depends on its copy number in cells and its genome size. Upon injection into a cell, the DNA establishes itself as a plasmid in a tandem structure. When such a plasmid in a high oligomeric structure is used as the source of packaging DNA, the packaging efficiency of the plasmids is elevated. The oligomers are stable in recA cells, whereas they drift toward lower oligomers in recA+ cells. Images PMID:6217189

  15. Optically active zwitterionic lambda(5)Si,lambda(5)Si'-disilicates: syntheses, crystal structures, and behavior in aqueous solution.

    PubMed

    Theis, Bastian; Burschka, Christian; Tacke, Reinhold

    2008-01-01

    The zwitterionic lambda(5)Si,lambda(5)Si'-disilicates 1-8 were synthesized and characterized by solid-state and solution NMR spectroscopy. In addition, compounds 26 H(2)O, 32 CH(3)CN, 45/2 CH(3)CN, 6CH(3)OH, 7, and 8CH(3)OHCH(3)CN were studied by single-crystal X-ray diffraction. The optically active (Delta,Delta,R,R,R,R)-configured compounds 1-8 contain two pentacoordinate (formally negatively charged) silicon atoms and two tetracoordinate (formally positively charged) nitrogen atoms. One (ammonio)alkyl group is bound to each of the two silicon centers, and two tetradentate (R,R)-tartrato(4-) ligands bridge the silicon atoms. Although these lambda(5)Si,lambda(5)Si'-disilicates contain SiO(4)C skeletons, some of them display a remarkable stability in aqueous solution as shown by NMR spectroscopy and ESI mass spectrometry.

  16. Somatic mutation in constant regions of mouse lambda 1 light chains.

    PubMed Central

    Motoyama, N; Okada, H; Azuma, T

    1991-01-01

    To study the distribution of somatic mutation, we determined nucleotide sequences of rearranged lambda 1-chain genomic DNA from four hybridomas obtained from C57BL/6 mice that had been immunized with (4-hydroxy-3-nitrophenyl)acetyl-conjugated chicken gamma globulin. In total, 114 nucleotide substitutions were observed, with neither insertion nor deletion. Sixty-one mutations occurred in the variable-joining region genes (V lambda 1-J lambda 1) and 49 in joining-constant (J lambda 1-C lambda 1) introns. Although frequency decreased with distance from the V lambda 1-J lambda 1 coding region, somatic mutations occurred in the entire J lambda 1-C lambda 1 intron and even in the C lambda 1 region. We found four nucleotide substitutions in C lambda 1 genes, all of which were replacement mutations. Therefore, the mechanism responsible for somatic mutation is operative into the C lambda 1 exons. Nucleotide sequences of rearranged but inactive lambda 2-chain genes from two hybridomas were also examined and compared with those of lambda 1-chain genes. The clustering of replacement mutations in complementarity-determining regions in the inactive lambda 2-chain genes similar to the active lambda 1-chain genes suggested a mechanism that induces somatic mutation preferentially in this region even in the absence of antigenic selection. PMID:1910169

  17. The First Generation of Stars in Lambda-CDM Cosmology

    SciTech Connect

    Gao, Liang; Abel, T.; Frenk, C.S.; Jenkins, A.; Springel, V.; Yoshida, N.; /Nagoya U.

    2006-10-10

    We have performed a large set of high-resolution cosmological simulations using smoothed particle hydrodynamics (SPH) to study the formation of the first luminous objects in the {Lambda}CDM cosmology. We follow the collapse of primordial gas clouds in eight early structures and document the scatter in the properties of the first star-forming clouds. Our first objects span formation redshifts from z {approx} 10 to z {approx} 50 and cover an order of magnitude in halo mass. We find that the physical properties of the central star-forming clouds are very similar in all of the simulated objects despite significant differences in formation redshift and environment. This suggests that the formation path of the first stars is largely independent of the collapse redshift; the physical properties of the clouds have little correlation with spin, mass, or assembly history of the host halo. The collapse of proto-stellar objects at higher redshifts progresses much more rapidly due to the higher densities, which accelerates the formation of molecular hydrogen, enhances initial cooling and shortens the dynamical timescales. The mass of the star-forming clouds cover a broad range, from a few hundred to a few thousand solar masses, and exhibit various morphologies: some have disk-like structures which are nearly rotational supported; others form flattened spheroids; still others form bars. All of them develop a single protostellar ''seed'' which does not fragment into multiple objects up to the moment that the central gas becomes optically thick to H{sub 2} cooling lines. At this time, the instantaneous mass accretion rate onto the centre varies significantly from object to object, with disk-like structures having the smallest mass accretion rates. The formation epoch and properties of the star-forming clouds are sensitive to the values of cosmological parameters.

  18. Non-LTE radiative transfer with lambda-acceleration - Convergence properties using exact full and diagonal lambda-operators

    NASA Technical Reports Server (NTRS)

    Macfarlane, J. J.

    1992-01-01

    We investigate the convergence properties of Lambda-acceleration methods for non-LTE radiative transfer problems in planar and spherical geometry. Matrix elements of the 'exact' A-operator are used to accelerate convergence to a solution in which both the radiative transfer and atomic rate equations are simultaneously satisfied. Convergence properties of two-level and multilevel atomic systems are investigated for methods using: (1) the complete Lambda-operator, and (2) the diagonal of the Lambda-operator. We find that the convergence properties for the method utilizing the complete Lambda-operator are significantly better than those of the diagonal Lambda-operator method, often reducing the number of iterations needed for convergence by a factor of between two and seven. However, the overall computational time required for large scale calculations - that is, those with many atomic levels and spatial zones - is typically a factor of a few larger for the complete Lambda-operator method, suggesting that the approach should be best applied to problems in which convergence is especially difficult.

  19. Interferon Lambda: Modulating Immunity in Infectious Diseases

    PubMed Central

    Syedbasha, Mohammedyaseen; Egli, Adrian

    2017-01-01

    Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade. Thereby hundreds of IFN-stimulated genes are induced, which modulate various immune functions via complex forward and feedback loops. When compared to the well-characterized IFN-α signaling cascade, three important differences have been discovered. First, the IFNLR is not ubiquitously expressed: in particular, immune cells show significant variation in the expression levels of and susceptibilities to IFN-λs. Second, the binding affinities of individual IFN-λs to the IFNLR varies greatly and are generally lower compared to the binding affinities of IFN-α to its receptor. Finally, genetic variation in the form of a series of single-nucleotide polymorphisms (SNPs) linked to genes involved in the IFN-λ signaling cascade has been described and associated with the clinical course and treatment outcomes of hepatitis B and C virus infection. The clinical impact of IFN-λ signaling and the SNP variations may, however, reach far beyond viral hepatitis. Recent publications show important roles for IFN-λs in a broad range of viral infections such as human T-cell leukemia type-1 virus, rotaviruses, and influenza virus. IFN-λ also potentially modulates the course of bacterial colonization and infections as shown for Staphylococcus aureus and Mycobacterium tuberculosis. Although the immunological processes involved in controlling viral and bacterial infections are distinct, IFN-λs may interfere at various levels: as an innate immune cytokine with direct antiviral effects; or as a modulator of IFN-α-induced signaling via the suppressor of cytokine signaling 1 and the ubiquitin-specific peptidase 18 inhibitory feedback loops. In addition, the modulation of adaptive immune functions via macrophage and

  20. [Study of the antigenic structure of human immunoglobulin lambda-chain using monoclonal antibodies].

    PubMed

    Arsen'eva, E L; Bogacheva, G T; Solomon, A; Weiss, D; Ibragimov, A R; Rokhlin, O V

    1990-01-01

    Nine monoclonals against human Ig lambda chains were produced, 4 antibodies react with C-domain, 5--with V-domain of the lambda chain. Anti-C lambda domain antibodies recognize not less than 3 epitopes and one of them is expressed only on the isolated chain. Anti-V lambda antibodies bind both isolated lambda chain and intact IgG, IgM, IgA. Four epitopes are expressed by few lambda Bence Jones proteins of the III subgroup, the immunogen possessing the same isotype. The 4 mentioned epitopes represent private idiotypic determinants. The epitope 3E10 is characteristic of 50% Bence Jones proteins of the II and III V lambda-subgroups thus representing a common idiotypic determinant. Using anti-V lambda antibodies germ line variability of V lambda III proteins was analysed and the similarity of antigenic structure of normal and myeloma human Ig lambda chains was demonstrated.

  1. Measurement of the branching fraction ${\\mathcal{B}}(\\Lambda^0_b\\rightarrow \\Lambda^+_c\\pi^-\\pi^+\\pi^-)$ at CDF

    SciTech Connect

    Aaltonen, T.; Alvarez Gonzalez, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J.A.; Arisawa, T.; Artikov, A.; /Dubna, JINR /Texas A-M

    2011-12-01

    We report an analysis of the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} decay in a data sample collected by the CDF II detector at the Fermilab Tevatron corresponding to 2.4 fb{sup -1} of integrated luminosity. We reconstruct the currently largest samples of the decay modes {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2595){sup +}{pi}{sup -} (with {Lambda}{sub c}(2595){sup +} {yields} {Lambda}{sub c}{sup +}{pi}{sup +}{pi}{sup -}), {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2625){sup +}{pi}{sup -} (with {Lambda}{sub c}(2625){sup +} {yields} {Lambda}{sub c}{sup +}{pi}{sup +}{pi}{sup -}), {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{pi}{sup -}{pi}{sup -} (with {Sigma}{sub c}(2455){sup ++} {yields} {Lambda}{sub c}{sup +}{pi}{sup +}), and {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455)0{pi}{sup +}{pi}{sup -} (with {Sigma}{sub c}(2455)0 {yields} {Lambda}{sub c}{sup +}{pi}{sup -}) and measure the branching fractions relative to the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -} branching fraction. We measure the ratio {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})/ {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -})=3.04 {+-} 0.33(stat){sub -0.55}{sup +0.70}(syst) which is used to derive {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})=(26.8{sub -11.2}{sup +11.9}) x 10{sup -3}.

  2. Measurement of the Lambda b0 lifetime in Lambda b0-->J/psi Lambda 0 in pp collisions at square root s=1.96 TeV.

    PubMed

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carrillo, S; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Cyr, D; DaRonco, S; D'Auria, S; Davies, T; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; DiTuro, P; Dörr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Labarga, L; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nagano, A; Naganoma, J; Nahn, S; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prokoshin, F; Pronko, A; Proudfoot, J; Ptochos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Sjolin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-03-23

    We report a measurement of the Lambda b0 lifetime in the exclusive decay Lambda b0-->J/psi Lambda 0 in pp collisions at square root s=1.96 TeV using an integrated luminosity of 1.0 fb-1 of data collected by the CDF II detector at the Fermilab Tevatron. Using fully reconstructed decays, we measure tau(Lambda b0)=1.593(-0.078)(+0.083)(stat)+/-0.033(syst) ps. This is the single most precise measurement of tau(Lambda b0) and is 3.2sigma higher than the current world average.

  3. First observation and measurement of the resonant structure of the lambda_b->lambda_c pi-pi+pi- decay mode

    SciTech Connect

    Azzurri, P.; Barria, P.; Ciocci, M.A.; Donati, S.; Vataga, E.

    2009-12-01

    The authors present the first observation of the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} decay using data from an integrated luminosity of approximately 2.4 fb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. They also present the first observation of the resonant decays {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup 0} {pi}{sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{pi}{sup -}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2595){sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} and {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2625){sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, and measure their relative branching ratios.

  4. Retroevolution of lambda Cro toward a stable monomer.

    PubMed

    LeFevre, Kelly R; Cordes, Matthew H J

    2003-03-04

    The Cro protein from bacteriophage lambda has a dimeric alpha+beta fold that evolved from an ancestral all-alpha monomer. The sequence mutations responsible for this dramatic structural evolution are unknown. Here we use analysis of sequence alignments to show that Ala-33, a small side chain in the hydrophobic "ball-and-socket" dimer interface of lambda Cro, was a much larger tryptophan side chain at a previous point in evolution. The retroevolutionary lambda Cro-A33W mutant shows a 10-fold reduction in dimerization affinity relative to the wild type as well as a large increase in monomer thermal stability (Delta T(m) > 10 degrees C), apparently due to partial filling of the hydrophobic socket from within the same monomer. An additional mutation in the dimer interface, F58D, almost completely abolishes detectable dimerization while maintaining the high monomer stability. The secondary structure content of the monomerized versions of lambda Cro is similar to that of the wild-type protein, and the tertiary structure of the monomer appears relatively well defined. These results (i) support a model in which the ball-and-socket dimer interface of lambda Cro was created by altered volume mutations within a limited branch of the Cro lineage and (ii) suggest the possibility that the evolution of the alpha+beta dimer from an all-alpha monomer proceeded through an alpha+beta monomer intermediate.

  5. A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda

    PubMed Central

    Zanghi, Christine N.; Lankes, Heather A.; Bradel-Tretheway, Birgit; Wegman, Jessica; Dewhurst, Stephen

    2005-01-01

    Bacteriophage lambda (λ) permits the display of many foreign peptides and proteins on the gpD major coat protein. However, some recombinant derivatives of gpD are incompatible with the assembly of stable phage particles. This presents a limitation to current λ display systems. Here we describe a novel, plasmid-based expression system in which gpD deficient λ lysogens can be co-complemented with both wild-type and recombinant forms of gpD. This dual expression system permits the generation of mosaic phage particles that contain otherwise recalcitrant recombinant gpD fusion proteins. Overall, this improved gpD display system is expected to permit the expression of a wide variety of peptides and proteins on the surface of bacteriophage λ and to facilitate the use of modified λ phage vectors in mammalian gene transfer applications. PMID:16224099

  6. Persistence behaviour of thiamethoxam and lambda cyhalothrin in transplanted paddy.

    PubMed

    Barik, Suhrid Ranjan; Ganguly, Pritam; Kunda, Samir Kumar; Kole, Ramen Kumar; Bhattacharyya, Anjan

    2010-10-01

    A field study was conducted in Pre-Kharif season 2007 on paddy to determine the persistence of thiamethoxam (12.6%) and lambda cyhalothrin (9.4%) [in a 'Readymix' formulation Alika 247 ZC], following the application of 33 g. a.i. ha⁻¹ (T₁) and 66 g. a.i. ha⁻¹ (T₂). Spraying of insecticide was done during milking stage of the crop (63 days after transplantation). Thiamethoxam and lambda cyhalothrin residues were estimated by HPLC and GLC respectively. The half-life values were 5.2-5.8 and 4.8 days for thiamethoxam and lambda cyhalothrin respectively. No residue was detected in the harvested paddy, straw, grain, and soil samples.

  7. Prediction of narrow N* and {Lambda}* with hidden charm

    SciTech Connect

    Wu Jiajun; Molina, R.; Oset, E.; Zou, B. S.

    2011-10-24

    The interaction between various charmed mesons and charmed baryons, such as D-bar{Sigma}{sub c}-D-bar{Lambda}{sub c}, D-bar*{Sigma}{sub c}-D-bar*{Lambda}{sub c}, and related strangeness channels, are studied within the framework of the coupled channel unitary approach with the local hidden gauge formalism. Six narrow N* and {Lambda}* resonances are dynamically generated with mass above 4 GeV and width smaller than 100 MeV. These predicted new resonances definitely cannot be accommodated by quark models with three constituent quarks. We make estimates of production cross sections of these predicted resonances in p-barp collisions for PANDA at the forthcoming FAIR facility.

  8. Characterization of a lymphoblastoid line deleted for lambda immunoglobulin genes

    SciTech Connect

    Hough, C.A., White, B.N., Holden, J.A.

    1995-04-01

    While characterizing the cat eye syndrome (CES) supernumerary chromosome for the presence of {lambda} immunoglobulin gene region sequences, a lymphoblastoid cell line from one CES patient was identified in which there was selection of cells deleted from some IGLC and IGLV genes. Two distinct deletions, one on each chromosome 22, were identified, presumably arising from independent somatic recombination events occurring during B-lymphocyte differentiation. The extent of the deleted regions was determined using probes from the various IGLV subgroups and they each covered at least 82 kilobases. The precise definition of the deletions was not possible because of conservation of some restriction sites in the IGLV region. The cell line was used to map putative IGLV genes within the recombinant phage {lambda}V{lambda}135 to the distal part of the IGLV gene region. 35 refs., 4 figs.

  9. Determination of the Lambda parameter from full lattice QCD

    SciTech Connect

    Goeckeler, M.; Horsley, R.; Irving, A.C.; Rakow, P.E.L.; Pleiter, D.; Schierholz, G.; Stueben, H.

    2006-01-01

    We present a determination of the QCD parameter {lambda} in the quenched approximation (n{sub f}=0) and for two flavors (n{sub f}=2) of light dynamical quarks. The calculations are performed on the lattice using O(a) improved Wilson fermions and include taking the continuum limit. We find {lambda}{sub n{sub f}=0}{sup MS}=259(1)(19) MeV and {lambda}{sub n{sub f}=2}{sup MS}=261(17)(26) MeV, using r{sub 0}=0.467 fm to set the scale. Extrapolating our results to five flavors, we obtain for the running coupling constant at the mass of the Z boson {alpha}{sub s}{sup MS}(m{sub Z})=0.112(1)(2)

  10. Observational constraints on late-time {lambda}(t) cosmology

    SciTech Connect

    Carneiro, S.; Pigozzo, C.; Dantas, M. A.; Alcaniz, J. S.

    2008-04-15

    The cosmological constant {lambda}, i.e., the energy density stored in the true vacuum state of all existing fields in the Universe, is the simplest and the most natural possibility to describe the current cosmic acceleration. However, despite its observational successes, such a possibility exacerbates the well-known {lambda} problem, requiring a natural explanation for its small, but nonzero, value. In this paper we study cosmological consequences of a scenario driven by a varying cosmological term, in which the vacuum energy density decays linearly with the Hubble parameter, {lambda}{proportional_to}H. We test the viability of this scenario and study a possible way to distinguish it from the current standard cosmological model by using recent observations of type Ia supernova (Supernova Legacy Survey Collaboration), measurements of the baryonic acoustic oscillation from the Sloan Digital Sky Survey, and the position of the first peak of the cosmic microwave background angular spectrum from the three-year Wilkinson Microwave Anisotropy Probe.

  11. LOCAL MEASUREMENT OF {Lambda} USING PULSAR TIMING ARRAYS

    SciTech Connect

    Espriu, Domenec; Puigdomenech, Daniel

    2013-02-20

    We consider the propagation of gravitational waves (GWs) in de Sitter spacetime and how a non-zero value of the cosmological constant might affect their detection in pulsar timing arrays (PTAs). If {Lambda} {ne} 0, the waves are anharmonic in Friedmann-Robertson-Walker coordinates, and although this effect is very small it gives rise to noticeable consequences for GWs originating in extragalactic sources such as spiraling black hole binaries. The results indicate that the timing residuals induced by GWs from such sources in PTAs will show a peculiar angular dependence with a marked enhancement around a particular value of the angle subtended by the source and the pulsars, depending mainly on the actual value of the cosmological constant and the distance to the source. The position of the peak could represent a gauge of the value of {Lambda}. The enhancement that the new effect brings about could facilitate the first direct detection of GWs while representing a local measurement of {Lambda}.

  12. Experimental transport studies of yttrium barium copper oxide and lambda-DNA

    NASA Astrophysics Data System (ADS)

    Zhang, Yuexing

    This dissertation consists of two parts. In Part I, we focus on the quasi-particle transport properties in the high temperature superconductor YBa2Cu3O7-delta (YBCO), probed by the thermal Hall conductivity (kappa xy). The thermal Hall conductivity selectively reflects the transport behaviors of the charge carriers. By measuring kappaxy in the normal state YBCO, we established a new method to determine the Wiedemann-Franz (WF) ratio in cuprates. We determined the Hall-channel WF ratio kappa xy/sigmaxyT in Cu and YBCO. In the latter, we uncovered a T-linear dependence and suppression of the Hallchannel WF ratio. The suppression of the Hall-channel WF ratio in systems with predominant electron-electron scattering will be discussed. Thermal transport behaviors of the quasi-particles in the mixed state were studied by measuring kappaxx and kappa xy in a high-purity YBCO crystal. From the field-dependence of the thermal conductivity kappaxx, we separated the quasi particle contribution (kappae) from the phonon background. In the Hall channel, we observed that the (weak-field) kappa xy increased 103-fold between T c (90 K) and 30 K, implying a 100-fold enhancement of the quasi-particle lifetime. We found that kappaxy exhibited a specific scaling behavior below ˜30 K. The implication of the scaling behavior will be discussed. In Part II, we describe an experiment on determining the electrical conductivity of the bacteriophage lambda-DNA, an issue currently under intense debate. We covalently bonded the DNA to Au electrodes by incorporating thiol modified dTTP into the 'sticky' ends of the lambda-DNA. Two-probe measurements on such molecules provided a lower bound for the resistivity rho > 10 6 mum at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. We stress the importance of eliminating salt residues in these measurements.

  13. Midrapidity Lambda and Lambda(macro) production in Au+Au collisions at the square root of [s(NN)]=130 GeV.

    PubMed

    Adler, C; Ahammed, Z; Allgower, C; Amonett, J; Anderson, B D; Anderson, M; Averichev, G S; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bichsel, H; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Boucham, A; Brandin, A; Bravar, A; Cadman, R V; Caines, H; Calderón de la Barca Sánchez, M; Cardenas, A; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chaloupka, P; Chattopadhyay, S; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; Deng, W S; Derevschikov, A A; Didenko, L; Dietel, T; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Faivre, J; Filimonov, K; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Grachov, O; Grigoriev, V; Guedon, M; Gushin, E; Hallman, T J; Hardtke, D; Harris, J W; Henry, T W; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Humanic, T J; Igo, G; Ishihara, A; Ivanshin, Yu I; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E G; Kaneta, M; Kaplan, M; Keane, D; Kiryluk, J; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Konstantinov, A S; Kopytine, M; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kunde, G J; Kunz, C L; Kutuev, R Kh; Kuznetsov, A A; Lakehal-Ayat, L; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lauret, J; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; LoCurto, G; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Ludlam, T; Lynn, D; Ma, J; Majka, R; Margetis, S; Markert, C; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnick, Yu; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mitchell, J; Moiseenko, V A; Moore, C F; Morozov, V; de Moura, M M; Munhoz, M G; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potrebenikova, E; Prindle, D; Pruneau, C; Putschke, J; Rai, G; Rakness, G; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Renault, G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Rykov, V; Sakrejda, I; Salur, S; Sandweiss, J; Saulys, A C; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schüttauf, A; Schweda, K; Seger, J; Seliverstov, D; Seyboth, P; Shahaliev, E; Shestermanov, K E; Shimanskii, S S; Shvetcov, V S; Skoro, G; Smirnov, N; Snellings, R; Sorensen, P; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A P; Sugarbaker, E; Suire, C; Sumbera, M; Surrow, B; Symons, T J M; de Toledo, A Szanto; Szarwas, P; Tai, A; Takahashi, J; Tang, A H; Thomas, J H; Thompson, M; Tikhomirov, V; Tokarev, M; Tonjes, M B; Trainor, T A; Trentalange, S; Tribble, R E; Trofimov, V; Tsai, O; Ullrich, T; Underwood, D G; Van Buren, G; VanderMolen, A M; Vasilevski, I M; Vasiliev, A N; Vigdor, S E; Voloshin, S A; Wang, F; Ward, H; Watson, J W; Wells, R; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Wood, J; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, W M; Zoulkarneev, R; Zubarev, A N

    2002-08-26

    We report the first measurement of strange (Lambda) and antistrange (Lambda macro) baryon production from square root of [s(NN)]=130 GeV Au+Au collisions at the Relativistic Heavy Ion Collider (RHIC). Rapidity density and transverse mass distributions at midrapidity are presented as a function of centrality. The yield of Lambda and Lambda; hyperons is found to be approximately proportional to the number of negative hadrons. The production of Lambda; hyperons relative to negative hadrons increases very rapidly with transverse momentum. The magnitude of the increase cannot be described by existing hadronic string fragmentation models alone.

  14. The algebraic theory of latent projectors in lambda matrices

    NASA Technical Reports Server (NTRS)

    Denman, E. D.; Leyva-Ramos, J.; Jeon, G. J.

    1981-01-01

    Multivariable systems such as a finite-element model of vibrating structures, control systems, and large-scale systems are often formulated in terms of differential equations which give rise to lambda matrices. The present investigation is concerned with the formulation of the algebraic theory of lambda matrices and the relationship of latent roots, latent vectors, and latent projectors to the eigenvalues, eigenvectors, and eigenprojectors of the companion form. The chain rule for latent projectors and eigenprojectors for the repeated latent root or eigenvalues is given.

  15. Properties of the Lambda(1670)(1-)/2 resonance.

    PubMed

    Manley, D M; Abaev, V V; Allgower, C E; Bekrenev, V; Briscoe, W J; Clajus, M; Comfort, J R; Craig, K; Grosnick, D; Isenhower, D; Knecht, N; Koetke, D D; Kulbardis, A A; Kozlenko, N G; Kruglov, S; Lolos, G; Lopatin, I V; Manweiler, R; Marusić, A; McDonald, S; Nefkens, B M K; Olmsted, J; Papandreou, Z; Peaslee, D C; Phaisangittisakul, N; Prakhov, S; Price, J W; Ramirez, A F; Sadler, M; Shafi, A; Spinka, H; Stanislaus, T D S; Starostin, A; Staudenmaier, H M; Strakovsky, I I; Supek, I; Tippens, W B

    2002-01-07

    Recently the Crystal Ball Collaboration measured precise new data for the near-threshold reaction K(-)p-->etaLambda, which is dominated by formation of the Lambda(1670)1 / 2(-). In this Letter, we present results of a unitary, multichannel analysis that incorporates the new Crystal Ball data. For our preferred fit, we obtain mass M = 1673+/-2 MeV, width Gamma = 23+/-6 MeV, and elasticity x = 0.37+/-0.07. This elasticity is significantly larger than previously recognized. Resonance parameters of our preferred fit are in striking agreement with the quark-model predictions of Koniuk and Isgur.

  16. Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development.

    PubMed

    Schubert, Rachel A; Dodd, Ian B; Egan, J Barry; Shearwin, Keith E

    2007-10-01

    CI represses cro; Cro represses cI. This double negative feedback loop is the core of the classical CI-Cro epigenetic switch of bacteriophage lambda. Despite the classical status of this switch, the role in lambda development of Cro repression of the P(RM) promoter for CI has remained unclear. To address this, we created binding site mutations that strongly impaired Cro repression of P(RM) with only minimal effects on CI regulation of P(RM). These mutations had little impact on lambda development after infection but strongly inhibited the transition from lysogeny to the lytic pathway. We demonstrate that following inactivation of CI by ultraviolet treatment of lysogens, repression of P(RM) by Cro is needed to prevent synthesis of new CI that would otherwise significantly impede lytic development. Thus a bistable CI-Cro circuit reinforces the commitment to a developmental transition.

  17. Observation of. lambda. -hypernuclei in the reaction /sup 12/C(. pi. /sup +/,K/sup +/)/sub. lambda. //sup 12/C

    SciTech Connect

    Milner, E.C.

    1985-12-01

    The observation of ..lambda..-hypernuclear levels in /sub ..lambda..//sup 12/C by associated production through the (..pi../sup +/,K/sup +/) reaction is reported. Spectrometers used in the measurements are discussed. The /sub ..lambda..//sup 12/C excitation energy spectra were recorded at laboratory scattering angles of 5.6/sup 0/, 10.3/sup 0/, and 15.2/sup 0/. The spectra show two major peaks - one attributed to the ground state, and one about 11 MeV higher in excitation. The peak near 11 MeV excitation energy is believed to be almost entirely composed of a multiplet of three J/sup ..pi../ = 2/sup +/ states. Relativistic DWBA calculations imply support for the expectation that higher spin states are preferentially populated in the (..pi../sup +/,K/sup +/) reaction, compared to the (K/sup -/,..pi../sup -/) reaction in which lower spin states are excited. 29 refs., 40 figs.

  18. LAMBDA Polarization with a Transversely Polarized Proton Target at the COMPASS Experiment

    SciTech Connect

    Negrini, Teresa

    2009-08-04

    The transverse polarization of LAMBDA and LAMBDA-bar hyperons is investigated at the COMPASS experiment at CERN. In 2007 a 160 GeV/c longitudinally polarized muon beam and a transversely polarized NH{sub 3} target were employed to study events in semi-inclusive deep-inelastic scattering. Preliminary results for the LAMBDA and LAMBDA-bar polarizations extracted from this new data set are presented as a function of x{sub Bj} and z. The polarizations of LAMBDA and LAMBDA-bar are compatible with zero within their error bars and no dependence on x{sub Bj} or z is observed.

  19. Transfection of E. coli with lambda DNA by electroporation.

    PubMed

    Magistrelli, C; Colombo, E; Tognoni, A; Grandi, G

    1992-10-01

    In the ambit of the B. subtilis genoma sequencing and mapping project, we have set up an electroporation method to transfect E. coli cells with lambda DNA. This methodology presents features that make it preferable to traditional in vitro packaging for some purposes. Here we will illustrate the experimental procedure and the possible applications.

  20. X-Ray Flare Characteristics in lambda Eridani

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.

    1997-01-01

    This proposal was for a joint X-ray/ultraviolet/ground-based study of the abnormal Be star lambda Eri, which has previously shown evidence of X-ray flaring from ROSAT observations in 1991. The X-ray component consisted of observations from both the ASCA and ROSAT satellites.

  1. X-Ray Flare Characteristics in Lambda Eridani

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.

    1997-01-01

    This proposal was for a joint X-ray/ultraviolet/ground-based study of the abnormal Be star lambda Eri, which has previously shown evidence of X-ray flaring from ROSAT observations in 1991. The X-ray component consisted of observations from both the ASCA and ROSAT satellites.

  2. A luminous efficiency function, V*(lambda), for daylight adaptation.

    PubMed

    Sharpe, Lindsay T; Stockman, Andrew; Jagla, Wolfgang; Jägle, Herbert

    2005-12-21

    We propose a new luminosity function, V*(lambda), that improves upon the original CIE 1924 V(lambda) function and its modification by D. B. Judd (1951) and J. J. Vos (1978), while being consistent with a linear combination of the A. Stockman & L. T. Sharpe (2000) long-wavelength-sensitive (L) and middle-wavelength-sensitive (M) cone fundamentals. It is based on experimentally determined 25 Hz, 2 degrees diameter, heterochromatic (minimum) flicker photometric data obtained from 40 observers (35 males, 5 females) of known genotype, 22 with the serine variant L(ser180), 16 with the alanine L(ala180) variant, and 2 with both variants of the L-cone photopigment. The matches, from 425 to 675 nm in 5-nm steps, were made on a 3 log troland xenon white (correlated color temperature of 5586 K but tritanopically metameric with CIE D65 standard daylight for the Stockman and Sharpe L- and M-cone fundamentals in quantal units) adapting field of 16 degrees angular subtense, relative to a 560-nm standard. Both the reference standard and test lights were kept near flicker threshold so that, in the region of the targets, the total retinal illuminance averaged 3.19 log trolands. The advantages of the new function are as follows: it forms a consistent set with the new proposed CIE cone fundamentals (which are the Stockman & Sharpe 2000 cone fundamentals); it is based solely on flicker photometry, which is the standard method for defining luminance; it corresponds to a central 2 degrees viewing field, for which the basic laws of brightness matching are valid for flicker photometry; its composition of the serine/alanine L-cone pigment polymorphism (58:42) closely matches the reported incidence in the normal population (56:44; Stockman & Sharpe, 1999); and it specifies luminance for a reproducible, standard daylight condition. V*(lambda) is defined as 1.55L(lambda) + M(lambda), where L(lambda) and M(lambda) are the Stockman & Sharpe L- & M-cone (quantal) fundamentals. It is extrapolated

  3. Heat capacity and thermal relaxation of bulk helium very near the lambda point

    NASA Technical Reports Server (NTRS)

    Lipa, John A.; Swanson, D. R.; Nissen, J. A.; Chui, T. C. P.

    1994-01-01

    In October 1992 a low temperature experiment was flown on the Space Shuttle in low Earth orbit. The objective of the mission was to measure the heat capacity and thermal conductivity of helium very close to the lambda point with the smearing effect of gravity removed. We report preliminary results from the experiment, and compare them with related measurements performed on the ground. The sample was s sphere of helium 3.5 cm in diameter contained within a copper calorimeter of vey high thermal conductivity. The calorimeter was attached to a pair of high resolution paramagnetic salt thermometers with noise levels in the 10(exp -10) K range and suspended from a high stability thermal isolation system. During the mission we found that the resolution of the thermometers was degraded somewhat due to the impact of charged particles. This effect limited the useful resolution of the measurements to about two nanokelvins from the lambda point. The results reported here are limited to about ten nanokelvins from the transition.

  4. Nonspecific binding of the OR repressors CI and Cro of bacteriophage lambda.

    PubMed

    Bakk, Audun; Metzler, Ralf

    2004-12-21

    We estimate the Gibbs free energy for nonspecific binding (DeltaGNSB) to the Escherichia coli DNA for two regulatory proteins of the lambda phage, CI and Cro. By means of a statistical-mechanical approach, we calculate the cI and cro activities associated with the operator OR of an introduced lambda phage genome (prophage). In this statistical model we apply in vitro-measured binding free energies to fit in vivo experimental data for cI and cro activities, respectively, where DeltaGNSB is introduced as a free (fitting) parameter. Without nonspecific binding included in the model, the quality of the description is fairly poor, whereas data are nicely correlating with our model with nonspecific binding included over the entire data range. The obtained values of DeltaGNSB are -4.1+/-0.9 kcal/mol, for CI, and -4.2+/-0.8 kcal/mol, for Cro. In particular, in a lysogen (approximately 250 CI monomers per cell) we conclude that 86% of the total CI in the cell is nonspecifically bound, leaving on average around 10 CI dimers freely available in the E. coli cytoplasma. These findings corroborate the view that due to low free cellular particle numbers a dynamical analysis of genetic regulation at OR and comparable systems should include a stochastic component. In addition, we perform a stability analysis of the OR system in the presence of nonspecific binding.

  5. Proteasome Inhibitors Enhance Bacteriophage Lambda (λ) Mediated Gene Transfer in Mammalian Cells

    PubMed Central

    Volcy, Ketna; Dewhurst, Stephen

    2009-01-01

    Bacteriophage lambda vectors can transfer their genomes into mammalian cells, resulting in expression of phage-encoded genes. However, this process is inefficient. Experiments were therefore conducted to delineate the rate limiting step(s) involved, using a phage vector that contains a mammalian luciferase reporter gene cassette. The efficiency of phage-mediated gene transfer in mammalian cells was quantitated, in the presence or absence of pharmacologic inhibitors of cell uptake and degradation pathways. Inhibitors of lysosomal proteases and proteasome inhibitors strongly enhanced phage-mediated luciferase expression, suggesting that these pathways contribute to the destruction of intracellular phage particles. In contrast, inhibition of endosome acidification had no effect on phage-mediated gene transfer, presumably because phage lambda is tolerant to extended exposure to low pH. These findings provide insights into the pathways by which phage vectors enter and transduce mammalian cells, and suggest that it may be possible to pharmacologically enhance the efficiency of phage-mediated gene transfer in mammalian cells. Finally, the data also suggest that the proteasome complex may serve as an innate defense mechanism that restricts the infection of mammalian cells by diverse viral agents. PMID:19064273

  6. Approaches for the direct estimation of lambda, and demographic contributions to lambda, using capture-recapture data

    USGS Publications Warehouse

    Nichols, J.D.; Hines, J.E.

    2002-01-01

    We first consider the estimation of the finite rate of population increase or population growth rate, lambda sub i, using capture-recapture data from open populations. We review estimation and modelling of lambda sub i under three main approaches to modelling open-population data: the classic approach of Jolly (1965) and Seber (1965), the superpopulation approach of Crosbie & Manly (1985) and Schwarz & Arnason (1996), and the temporal symmetry approach of Pradel (1996). Next, we consider the contributions of different demographic components to lambda sub i using a probabilistic approach based on the composition of the population at time i + 1 (Nichols et al., 2000b). The parameters of interest are identical to the seniority parameters, gamma sub i, of Pradel (1996). We review estimation of gamma sub i under the classic, superpopulation, and temporal symmetry approaches. We then compare these direct estimation approaches for lambda sub i and gamma sub i with analogues computed using projection matrix asymptotics. We also discuss various extensions of the estimation approaches to multistate applications and to joint likelihoods involving multiple data types.

  7. Differential equations whose solution of the Cauchy problem displays nonclassical behaviour with respect to the parameter {lambda}

    SciTech Connect

    Yakubov, Vladimir Ya

    2009-10-31

    The behaviour of solutions of the equation y''+{lambda}{rho}(x,{lambda})y=0 with respect to the spectral parameter {lambda} is investigated under the assumption that the function {rho}(x,{lambda}) does not satisfy the classical conditions. Two types of equations are considered: the Sturm-Liouville equation y''+{lambda}{rho}(x)y=0, whose solutions grow like c({rho}){lambda}{sup m} in the norm of C[0,l] (where m>0 is arbitrary), and equations of the form y''+{lambda}{rho}(x,{lambda})y=0, lim {sub {lambda}}{sub {yields}}{sub +{infinity}}{rho}(x,{lambda})=1, whose solutions can grow like c{lambda}{sup m} in the norm of C[0,l] (where m>0 is arbitrary) and even like exp{l_brace}m{lambda}{sup 1-{gamma}}{r_brace} where 0<{gamma}<1. Bibliography: 3 titles.

  8. K0(s) and Lambda0 production studies in p anti-p collisions at s**(1/2) = 1800 and 630-GeV

    SciTech Connect

    Acosta, D.; Affolder, Anthony A.; Albrow, M.G.; Ambrose, D.; Amidei, D.; Anikeev, K.; Antos, J.; Apollinari, G.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Azfar, F.; Azzi-Bacchetta, P.; Bacchetta, N.; Bachacou, H.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Baroiant, S.; Barone, M.; /Taiwan, Inst. Phys. /Argonne /INFN, Bologna /Bologna U. /Brandeis U. /UC, Davis /UCLA /UC, Santa Barbara /Cantabria Inst. of Phys. /Carnegie Mellon U. /Chicago U., EFI /Dubna, JINR /Duke U. /Fermilab /Florida U. /Frascati /Geneva U. /Glasgow U. /Harvard U. /Hiroshima U. /Johns Hopkins U.

    2005-04-01

    The authors present a study of the production of K{sub s}{sup 0} and {Lambda}{sup 0} in inelastic p{bar p} collisions at {radical}s = 1800 and 630 GeV using data collected by the CDF experiment at the Fermilab Tevatron. Analyses of K{sub s}{sup 0} and {Lambda}{sup 0} multiplicity and transverse momentum distributions, as well as of the dependencies of the average number and (p{sub T}) of K{sub s}{sup 0} and {Lambda}{sup 0} on charged particle multiplicity are reported. Systematic comparisons are performed for the full sample of inelastic collisions, and for the low and high momentum transfer subsamples, at the two energies. The p{sub T} distributions extend above 8 GeV/c, showing a (p{sub T}) higher than previous measurements. The dependence of the mean K{sub s}{sup 0}({Lambda}{sup 0}) p{sub T} on the charged particle multiplicity for the three samples shows a behavior analogous to that of charged primary tracks.

  9. {lambda}{sup 0} Polarization in pp{yields}p{lambda}{sup 0}K{sup +} at 800 GeV/c

    SciTech Connect

    Valencia, E.; Felix, J.; Reyes, M. A.; Wang, M. H. L. S.; Berisso, M. C.; Kreisler, M. N.; Lee, S.; Markianos, K.; Wesson, D.; Christian, D. C.; Gottschalk, E.; Gutierrez, G.; Wehmann, A.; Gara, A.; Knapp, B. C.; Hartouni, E. P.

    2008-07-02

    We determined {lambda}{sup 0} polarization as function of X{sub F}, P{sub T}, M{sub X}, and E{sub {lambda}}, with respect to the normal of the following two different production planes: The first one defined by the momentum of the 800 GeV/c proton beam and the moment of {lambda}{sup 0}; the second one, by the momentum of the transferred object and the momentum of {lambda}{sup 0}, from the sample created in the FNAL E690 experiment. We present results, compare and discuss them.

  10. First Observation of Charmed Resonances in the $\\Lambda^0_b \\to \\Lambda^+_c \\pi^- \\pi^+ \\pi^-$ Inclusive Decay and Measurement of Their Relative Branching Ratios at CDF

    SciTech Connect

    Barria, Patrizia

    2012-01-01

    We present the observation of the $\\Lambda^0_b$ decay into a $\\Lambda^+_c \\pi^- \\pi^+ \\pi^-$ final state, in $p\\bar{p}$ collisions at $\\sqrt{s}$ = 1:96 TeV. The data analyzed were collected by the CDF II detector at the Fermilab Tevatron collider, and correspond to 2:4 $fb^{-1}$ of integrated luminosity. We fit the invariant mass distribution of the reconstructed candidates to extract a signal yield of 848 $\\pm$ 93 $\\Lambda^0_b$ into $\\Lambda^+_c \\pi^- \\pi^+ \\pi^-$....

  11. Fourth generation effect on {Lambda}{sub b} decays

    SciTech Connect

    Mohanta, R.; Giri, A. K.

    2010-11-01

    The rare decays of the {Lambda}{sub b} baryon governed by the quark level transitions b{yields}s are investigated in the fourth quark generation model popularly known as SM4. Recently it has been shown that SM4, which is a very simple extension of the standard model, can successfully explain several anomalies observed in the CP violation parameters of B and B{sub s} mesons. We find that in this model due to the additional contributions coming from the heavy t{sup '} quark in the loop, the branching ratios and other observables in rare {Lambda}{sub b} decays deviate significantly from their standard model values. Some of these modes are within the reach of the LHCb experiment and search for such channels is strongly argued.

  12. Giant magnons of string theory in the lambda background

    NASA Astrophysics Data System (ADS)

    Appadu, Calan; Hollowood, Timothy J.; Miramontes, J. Luis; Price, Dafydd; Schmidtt, David M.

    2017-07-01

    The analogues of giant magnon configurations are studied on the string world sheet in the lambda background. This is a discrete deformation of the AdS5× S 5 background that preserves the integrability of the world sheet theory. Giant magnon solutions are generated using the dressing method and their dispersion relation is found. This reduces to the usual dyonic giant magnon dispersion relation in the appropriate limit and becomes relativistic in another limit where the lambda model becomes the generalized sine-Gordon theory of the Pohlmeyer reduction. The scattering of giant magnons is then shown in the semi-classical limit to be described by the quantum S-matrix that is a quantum group deformation of the conventional giant magnon S-matrix. It is further shown that in the small g limit, a sector of the S-matrix is related to the XXZ spin chain whose spectrum matches the spectrum of magnon bound states.

  13. Threshold Properties of the K{Lambda} Photoproduction

    SciTech Connect

    Mart, T.

    2010-12-23

    We have investigated kaon photoproduction on a proton and a neutron near their production thresholds by utilizing an isobar model. The background term of the model is constructed from Feynman diagrams, while the resonance term is derived from the multipoles formalism. In the case of the {gamma}+p{yields}K{sup +}+{Lambda} channel we found that both pseudoscalar (PS) and pseudovector (PV) models are able to reproduce the available photoproduction data up to W = 50 MeV above the threshold. The hyperon resonance S{sub 01}(1800) is found to be important in improving the agreement between model calculation and experimental data. In the case of double polarization observables O{sub x}, and O{sub z}, our result is in agreement with the finding of Sandorfi et al. In the {gamma}+n{yields}K{sup 0}+{Lambda} channel we found that the difference between PS and PV models is sizable for future experiments.

  14. Efficient epitope mapping by bacteriophage {lambda} surface display

    SciTech Connect

    Kuwabara, I.; Maruyama, H.; Zuberi, R.I.

    1997-01-01

    A bacteriophage {lambda} surface expression system, {lambda}foo, was used for epitope mapping of human galectin-3. We constructed random epitope and peptide libraries and compared their efficiencies in the mapping. The galectin-3 cDNA was randomly digested by DNase I to make random epitope libraries. The libraries were screened by affinity selection using a microtiter plate coated with monoclonal antibodies. Direct DNA sequencing of the selected clones defined two distinct epitope sites consisting of nine and 11 amino-acid residues. Affinity selection of random peptide libraries recovered a number of sequences that were similar to each other but distinct from the galectin-3 sequence. These results demonstrate that a single affinity selection of epitope libraries with antibodies is able to define an epitope determinant as small as nine residues long and is more efficient in epitope mapping than random peptide libraries. 25 refs., 4 figs., 1 tab.

  15. The lambda-scheme method applied to Stirling engines

    NASA Astrophysics Data System (ADS)

    Franco, R.

    1985-12-01

    An integration method of the motion equations is the so-called 'lambda-scheme': such a method suggests that, in the numerical procedure of the approximation of the derivatives in space with finite differences, the physical domains of dependence have to be correctly taken into account, according to the wave propagation through the flow. In the lambda-scheme method, the codes are simple, the computing time is kept very low, while accuracy (second-order in space and time) of the results is very satisfactory. As a matter of fact, the simulation model here discussed leads to a deeper analysis and a closer prediction of Stirling engine performances. As a first approach, a feasibility analysis is carried out for an expansion space-heat exchanger flow duty simulation.

  16. Sequence-Dependent Pausing of Single Lambda Exonuclease Molecules

    NASA Astrophysics Data System (ADS)

    Perkins, Thomas T.; Dalal, Ravindra V.; Mitsis, Paul G.; Block, Steven M.

    2003-09-01

    Lambda exonuclease processively degrades one strand of duplex DNA, moving 5'-to-3' in an ATP-independent fashion. When examined at the single-molecule level, the speeds of digestion were nearly constant at 4 nanometers per second (12 nucleotides per second), interspersed with pauses of variable duration. Long pauses, occurring at stereotypical locations, were strand-specific and sequence-dependent. Pause duration and probability varied widely. The strongest pause, GGCGATTCT, was identified by gel electrophoresis. Correlating single-molecule dwell positions with sequence independently identified the motif GGCGA. This sequence is found in the left lambda cohesive end, where exonuclease inhibition may contribute to the reduced recombination efficiency at that end.

  17. LAMBDA — Large Area Medipix3-Based Detector Array

    NASA Astrophysics Data System (ADS)

    Pennicard, D.; Lange, S.; Smoljanin, S.; Hirsemann, H.; Graafsma, H.

    2012-11-01

    Medipix3 is a photon-counting readout chip for X-ray detection. It has a small pixel size (55 μm) and a high frame rate with zero dead time, which makes it attractive for experiments at synchrotrons. Using Medipix3, DESY are developing the LAMBDA (Large Area Medipix3-Based Detector Array) system. A single LAMBDA module carries either a single large silicon sensor of 1536 by 512 pixels, or two smaller high-Z sensors. The sensor is bonded to 12 Medipix3 chips, and mounted on a ceramic carrier board. The readout system for the module then provides a fast FPGA, a large RAM and four 10 Gigabit Ethernet links to allow operation at high frame rates. Multiple modules may then be tiled together a larger area. Currently, the first large silicon modules have been constructed and tested at low speed, and the firmware for fast readout is being developed.

  18. Lambda modes of the neutron diffusion equation in hexagonal geometry

    SciTech Connect

    Barrachina, T.; Ginestar, D.; Verdu, G.

    2006-07-01

    A nodal collocation method is proposed to compute the dominant Lambda modes of nuclear reactor core with a hexagonal geometry. This method is based on a triangular mesh and assumes that the neutronic flux can be approximated as a finite expansion in terms of Dubiner's polynomials. The method transforms the initial differential eigenvalue problem into a generalized algebraic one, from which the dominant modes of the reactor can be computed. The performance of the method is tested with two benchmark problems. (authors)

  19. Characterization of SAL605 negative resist at {lambda}=13 nm

    SciTech Connect

    La Fontaine, B.; Ciarlo, D.; Gaines, D.P.; Kania, D.R.

    1996-05-24

    We have characterized the response of the negative resist SAL605 in the extreme ultraviolet ({lambda}=13 nm). The sensitivity was found to be {approx}1 mJ/cm{sup 3} for all conditions studied. We have identified processing conditions leading to high ({gamma}{gt}4) contrast. The resist response was modeled using Prolith/2 and the development parameters were obtained from the exposure curves.

  20. Specialized transduction of D-serine deaminase genes: formation of lysogens that yield high lambda-d dsd/lambda ratios and formation of a dimeric lambda-d dsd.

    PubMed

    Palchaudhuri, S; McFall, E; Carothers, A M

    1976-08-01

    We have obtained two classes of double lysogens that on induction yield higher titers of lambda-d dsd transducing phage than of helper phage. One class was obtained by lysogenization of strain EM6116 (dsddelta attlambdadelta HfrC) with lambda-dsd type 2 (dsdC+ dsdO+ dsdA+, head-tail substitution). In the absence of either a normal attlambda or the homology of a chromosomal dsd region, the transducing phage integrated at other sites, at least one of which, in strain EM6177, is near the origin of HfrC. On induction, strain EM6177 yields a phage burst of 20 to 50 with a lambdadsd:lambda ratio of 10(4):1. The asnychronously high yield of lambda dsd is attributed to an efficiency of excision greater than that of lambda. The other class was obtained by lysogenization of strain EM1407 (dsdA attlambda+) with lambda-dsd type 2 (dsdO6 dsdA, partial deletion of dsdC). The DNA of mature lambda-dsd type 2 is a complete dimer. It lacks nearly all the phage late genes and b2 and carries about five bacterial genes. It could not be packaged as a monomer but is just within the packaging size limit as a dimer. Models for the derivation of these lambda dsd phages and the high-yielding lysogens are presented.

  1. Specialized transduction of D-serine deaminase genes: formation of lysogens that yield high lambda-d dsd/lambda ratios and formation of a dimeric lambda-d dsd.

    PubMed Central

    Palchaudhuri, S; McFall, E; Carothers, A M

    1976-01-01

    We have obtained two classes of double lysogens that on induction yield higher titers of lambda-d dsd transducing phage than of helper phage. One class was obtained by lysogenization of strain EM6116 (dsddelta attlambdadelta HfrC) with lambda-dsd type 2 (dsdC+ dsdO+ dsdA+, head-tail substitution). In the absence of either a normal attlambda or the homology of a chromosomal dsd region, the transducing phage integrated at other sites, at least one of which, in strain EM6177, is near the origin of HfrC. On induction, strain EM6177 yields a phage burst of 20 to 50 with a lambdadsd:lambda ratio of 10(4):1. The asnychronously high yield of lambda dsd is attributed to an efficiency of excision greater than that of lambda. The other class was obtained by lysogenization of strain EM1407 (dsdA attlambda+) with lambda-dsd type 2 (dsdO6 dsdA, partial deletion of dsdC). The DNA of mature lambda-dsd type 2 is a complete dimer. It lacks nearly all the phage late genes and b2 and carries about five bacterial genes. It could not be packaged as a monomer but is just within the packaging size limit as a dimer. Models for the derivation of these lambda dsd phages and the high-yielding lysogens are presented. Images PMID:783126

  2. Measurement of sigma Lambda b0/sigma B0 x B(Lambda b0-->Lambda c+pi-)/B(B0-->D+pi-) in pp collisions at square root s=1.96 TeV.

    PubMed

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Cyr, D; DaRonco, S; D'Auria, S; Davies, T; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; DiTuro, P; Dörr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Le, Y; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nagano, A; Naganoma, J; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Sjolin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tseng, J; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-03-23

    We present the first observation of the baryon decay Lambda b0-->Lambda c+pi- followed by Lambda c+-->pK-pi+ in 106 pb-1 pp collisions at square root s=1.96 TeV in the CDF experiment. In order to reduce systematic error, the measured rate for Lambda b0 decay is normalized to the kinematically similar meson decay B0-->D+pi- followed by D+-->pi+K-pi+. We report the ratio of production cross sections (sigma) times the ratio of branching fractions (B) for the momentum region integrated above pT>6 GeV/c and pseudorapidity range |eta|<1.3: sigma(pp-->Lambda b0X)/sigma(pp-->B0X)xB(Lambda b0-->Lambda c+pi-)/B(B0-->D+pi-)=0.82+/-0.08(stat)+/-0.11(syst)+/-0.22[B(Lambda c+-->pK-pi+)].

  3. An investigation of the {anti p}p {yields} {anti {Lambda}} {Lambda} and {anti p}p {yields} {anti {Sigma}}{sup 0} {Lambda} + c.c. reactions near threshold

    SciTech Connect

    Tayloe, R.; PS185 Collaboration

    1995-12-31

    Experiment PS 185 studies the production of antihyperon-hyperon pairs in antiproton-proton collisions at LEAR in the near-threshold energy region. The {ital {anti p} p} {r_arrow} {anti {Lambda}}{Lambda} reaction has been thoroughly studied by PS185 and many high-quality data have been reported. New results, including total and differential cross sections along with spin observables, are presented here for the channels {ital {anti p} p} {r_arrow} {anti {Lambda}}{Lambda} and {ital {anti p}p} {r_arrow} {anti {Sigma}}{sup 0}{Lambda} + c.c at incident lab antiproton momenta of 1.726 and 1. 771 GeV/c. The data from the relatively unstudied and complementary {ital {anti p}p} {r_arrow} {anti {Sigma}}{sup 0}{Lambda} + c.c channel is compared to that from {ital {anti p}p} {r_arrow} {anti {Lambda}}{Lambda} at similar energies above the reaction threshold.

  4. ({lambda}, p) Spectrum Analysis in p+A Interactions at 10 GeV/c

    SciTech Connect

    Aslanyan, P. Zh.; Emelyanenko, V. N.

    2007-06-13

    Experimental data from the 2m propane bubble chamber have been analyzed for exotic baryon states search. A number of peculiarities were found in the effective mass spectra of: {lambda}{pi}+({sigma}*+(1382),PDG), {lambda}p and {lambda}pp subsystems. A few events detected on the photographs of the propane bubble chamber exposed to a 10 GeV/c proton beam, were interpreted as S=-2 H0 light(lambda}{lambda})) and heavy H0,+. New event, detected on the photographs of the propane bubble chamber was interpreted as heavy H+(2488) dibaryon by two weak decay channels of K-pp or {sigma}+p{pi}-.

  5. Quantum inverse scattering and the lambda deformed principal chiral model

    NASA Astrophysics Data System (ADS)

    Appadu, Calan; Hollowood, Timothy J.; Price, Dafydd

    2017-07-01

    The lambda model is a one parameter deformation of the principal chiral model that arises when regularizing the non-compactness of a non-abelian T dual in string theory. It is a current-current deformation of a WZW model that is known to be integrable at the classical and quantum level. The standard techniques of the quantum inverse scattering method cannot be applied because the Poisson bracket is non ultra-local. Inspired by an approach of Faddeev and Reshetikhin, we show that in this class of models, there is a way to deform the symplectic structure of the theory leading to a much simpler theory that is ultra-local and can be quantized on the lattice whilst preserving integrability. This lattice theory takes the form of a generalized spin chain that can be solved by standard algebraic Bethe Ansatz techniques. We then argue that the IR limit of the lattice theory lies in the universality class of the lambda model implying that the spin chain provides a way to apply the quantum inverse scattering method to this non ultra-local theory. This points to a way of applying the same ideas to other lambda models and potentially the string world-sheet theory in the gauge-gravity correspondence.

  6. Measurement of the Lambda0(b) Lifetime in Lambda0(b) ---> J/psi Lambda0 in p anti-p Collisions at s**(1/2) = 1.96-TeV

    SciTech Connect

    Abulencia, A.; Adelman, J.; Affolder, T.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; Annovi, A.; /Taiwan, Inst. Phys. /Argonne /Barcelona, IFAE /Baylor U. /INFN, Bologna /Bologna U. /Brandeis U. /UC, Davis /UCLA /UC, San Diego /UC, Santa Barbara

    2006-09-01

    The authors report a measurement of the {Lambda}{sub b}{sup 0} lifetime in the exclusive decay {Lambda}{sub b}{sup 0} {yields} J/{psi}{Lambda}{sup 0} in p{bar p} collisions at {radical}s = 1.96 TeV using an integrated luminosity of 1.0 fb{sup -1} of data collected by the CDF II detector at the Fermilab Tevatron. Using fully reconstructed decays, they measure {tau}({Lambda}{sub b}{sup 0}) = 1.593{sub -0.078}{sup +0.083}(stat.) {+-} 0.033(syst.) ps. This is the single most precise measurement of {tau}({Lambda}{sub b}{sup 0}) and is 3.2 {sigma} higher than the current world average.

  7. The role of template superhelicity in the initiation of bacteriophage lambda DNA replication.

    PubMed Central

    Alfano, C; McMacken, R

    1988-01-01

    The prepriming steps in the initiation of bacteriophage lambda DNA replication depend on the action of the lambda O and P proteins and on the DnaB helicase, single-stranded DNA binding protein (SSB), and DnaJ and DnaK heat shock proteins of the E. coli host. The binding of multiple copies of the lambda O protein to the phage replication origin (ori lambda) initiates the ordered assembly of a series of nucleoprotein structures that form at ori lambda prior to DNA unwinding, priming and DNA synthesis steps. Since the initiation of lambda DNA replication is known to occur only on supercoiled templates in vivo and in vitro, we examined how the early steps in lambda DNA replication are influenced by superhelical tension. All initiation complexes formed prior to helicase-mediated DNA-unwinding form with high efficiency on relaxed ori lambda DNA. Nonetheless, the DNA templates in these structures must be negatively supertwisted before they can be replicated. Once DNA helicase unwinding is initiated at ori lambda, however, later steps in lambda DNA replication proceed efficiently in the absence of superhelical tension. We conclude that supercoiling is required during the initiation of lambda DNA replication to facilitate entry of a DNA helicase, presumably the DnaB protein, between the DNA strands. Images PMID:2847118

  8. Study of the ^7_{Lambda}He hypernucleus in formalism of the Faddeev equations

    SciTech Connect

    Igor Filikhin; Vladimir M. Suslov; Branislav Vlahovic

    2006-02-01

    P-shell A = 7 hypernuclei are considered in the cluster {sub {Lambda}}{sup 5}He + N + N model. The folding procedure are applied to construct the {sub {Lambda}}{sup 5}He-N interaction. We use the OBE simulating NSC97f potential for {Lambda}N interaction and various phenomenological potentials for {alpha}{Lambda} interaction. Configuration space Faddeev calculations are performed for hyperon binding energy of the {sub {Lambda}}{sup 7}He(1/2{sup +}) and {sub {lambda}}{sup 7}Li(1/2{sup +} and 3/2{sup +}, T=0) nuclei. Predicted value for B{sub {Lambda}}({sub {Lambda}}{sup 7}He) is 5.35 MeV. This value is obtained when the {sup {Lambda}}{sup 6}He(2{sup -}) excitation energy is equal 0.26 MeV by the adjustment of pair {sub {Lambda}}{sup 5}He-N effective potential to reproduce the experimental value of the {sub {Lambda}}{sup 7}Li(3/2{sup +}) excitation energy. Our results are compared with those of E. Hiyama et al.

  9. Study of inclusive. Lambda. production in e sup + e minus annihilations at 29 GeV

    SciTech Connect

    Geld, T.L.; Neal, H.; Akerlof, C.; Chapman, J.; Errede, D.; Ken, M.T.; Kesten, P.; Meyer, D.I.; Nitz, D.; Thun, R.; Tschirhart, R. ); Abachi, S.; Derrick, M.; Kooijman, P.; Musgrave, B.; Price, L.; Repond, J.; Sugano, K. ); Blockus, D.; Brabson, B.B.; Brom, J.; Jung, C.; Ogren, H.; Rust, D.R.; Snyder, A. ); Cork, B. ); Baringer, P.; Bylsma, B.G.; Debonte, R.; Low, E.H.; McIlwain, R.L.; Miller, D.H.; Ng, C.R.; Rangan, K.; Shibata, E. )

    1992-06-01

    Cross sections are presented for the inclusive production of {Lambda} hyperons in electron-positron annihilations at {radical}{ital s} =29 GeV based on the full 291-pb{sup {minus}1} sample of data taken in the High Resolution Spectrometer experiment at the SLAC {ital e}{sup +}{ital e}{minus} storage ring PEP. These results, and the associated correlation analyses, are consistent with the Lund model predictions with the strange diquark suppression ratio {delta} fixed at 0.59{plus minus}0.10{plus minus}0.18, as compared to the standard Lund value of 0.32. The {Lambda} multiplicity has been found to be 0.182{plus minus}0.020 per event. The opposite-strangeness multiplicity {l angle}{ital n}{sub {Lambda}}{Lambda}{bar a}{r angle} has been measured to be 0.046{plus minus}0.020, whereas the like-strangeness multiplicity {l angle}{ital n}{sub {Lambda}{Lambda}}+{bar {Lambda}}{bar {Lambda}}{r angle} is 0.009{plus minus}0.028. A strong correlation is found between {Lambda}'s and {bar {Lambda}} 's; when one is found in an event, the other is found in the same event with a probability that exceeds 50%.

  10. Inclusive Lambda_c Production in e+e- Annihilations at sqrt{s}=10.54 GeV and in Upsilon(4S) Decays

    SciTech Connect

    Aubert, B.

    2006-09-07

    We present measurements of the total production rates and momentum distributions of the charmed baryon {Lambda}{sub c}{sup +} in e{sup +}e{sup -} {yields} hadrons at a center-of-mass energy of 10.54 GeV and in {Upsilon}(4S) decays. In hadronic events at 10.54 GeV, charmed hadrons are almost exclusively leading particles in e{sup +}e{sup -} {yields} c{bar c} events, allowing direct studies of c-quark fragmentation. We measure a momentum distribution for {Lambda}{sub c}{sup +} baryons that differs significantly from those measured previously for charmed mesons. Comparing with a number of models, we find none that can describe the distribution completely. We measure an average scaled momentum of (x{sub p}) = 0.574 {+-} 0.009 and a total rate of N{sub {Lambda}{sub c}}{sup q{bar q}} = 0.057 {+-} 0.002(exp.) {+-} 0.015(BF) {Lambda}{sub c}{sup +} per hadronic event, where the experimental error is much smaller than that due to the branching fraction into the reconstructed decay mode, pK{sup -} {pi}{sup +}. In {Upsilon}(4S) decays we measure a total rate of N{sub {Lambda}{sub c}}{sup {Upsilon}} = 0.091 {+-} 0.006(exp.) {+-} 0.024(BF) per {Upsilon}(4S) decay, and find a much softer momentum distribution than expected from B decays into a {Lambda}{sub c}{sup +} plus an antinucleon and one to three pions.

  11. Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.

    PubMed

    Mattiacio, Jonelle; Walter, Scott; Brewer, Matt; Domm, William; Friedman, Alan E; Dewhurst, Stephen

    2011-03-21

    The generation of strong, virus-neutralizing antibody responses to the HIV-1 envelope spike (Env) is a major goal in HIV-1 vaccine research. To try to enhance the Env-specific response, we displayed oligomeric gp140 on a virus-like scaffold provided by the lambda phage capsid. To do this, an in vitro complementation system was used to "decorate" phage particles with glycosylated, mammalian cell-derived envelope oligomers. We compared the immune response to lambda phage particles displaying HIV-1 Env to that elicited by soluble oligomeric gp140 in rabbits. Env-binding antibody titers were higher in animals that received oligomeric gp140 as compared to Env decorated phage particles, as were virus neutralizing antibody responses. The Env decorated phage particles were, however, able to efficiently boost a protein-primed humoral response to levels equivalent to those elicited by high-dose adjuvanted Env oligomers. These results show that display of HIV-1 envelope spikes on the bacteriophage lambda capsid does not result in an improved, Env-specific humoral immune response. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. Search for CP violation in charged-Xi and Lambda hyperon decays

    SciTech Connect

    Holmstrom, T.; Leros, N.; Burnstein, R.A.; Chakravorty, A.; Chan, A.; Chen, Y.C.; Choong, W.S.; Clark, K.; Dukes, E.C.; Durandet, C.; Felix, J.; Fu, Y.; Gidal, G.; Gu, P.; Gustafson, H.R.; Ho, C.; Huang, M.; James, C.; Jenkins, C.M.; Jones, T.; Kaplan, D.M.; /Virginia U. /Lausanne U. /Taiwan, Inst. Phys. /UC, Berkeley /Fermilab /Guanajuato U. /IIT, Chicago /Lausanne U. /LBL, Berkeley /Michigan U. /South Alabama U. /Virginia U.

    2004-12-01

    The authors have compared the p and {bar p} angular distributions in 117 million {Xi}{sup -} {yields} {Lambda}{pi}{sup -} {yields} p{pi}{sup -}{pi}{sup -} and 41 million {Xi}{sup +} {yields} {bar {Lambda}}{pi}{sup +} {yields} {bar p}{pi}{sup +}{pi}{sup +} decays using a subset of the data from the HyperCP experiment (ES71) at Fermilab. They find no evidence of CP violation, with the direct-CP-violating parameter A{sub {Xi}{Lambda}} {triple_bond} (a{sub {Xi}}a{sub {Lambda}} - {bar a}{sub {Xi}}{bar a}{sub {Lambda}})/(a{sub {Xi}}a{sub {Lambda}} + {bar a}{sub {Xi}}{bar a}{sub {Lambda}}) = [0.0 {+-} 5.1(stat) {+-} 4.4(syst)] x 10{sup -4}.

  13. Utilizing Synthetic Spectra to Refine Lambda Boo Stars' UV Classification Criteria

    NASA Astrophysics Data System (ADS)

    Cheng, Kwang-Ping; Neff, James E.; Johnson, Dustin; Tarbell, Erik; Romo, Christopher; Steele, Patricia; Gray, Richard O.; Corbally, Christopher J.

    2016-01-01

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This stellar class has recently regained the spotlight because of the directly-imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. This possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Bootis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. The Lambda Boo label has been applied to almost any peculiar A-type stars that do not fit elsewhere. In order to determine the origin of Lambda Boo stars' unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. Using observed and synthetic spectra, we explored the classification of Lambda Boo stars and developed quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. With model spectra, we demonstrated that the (C I 1657 Angstrom)/ (Al II 1671 Angstrom) line ratio is the best single criterion to distinguish between Lambda Boo stars and metal weak stars, and that one cannot use a single C I/Al II cut-off value as a Lambda Boo classification criterion. The C I/Al II cut-off value is a function of a star's effective temperature and metallicity. Using these stricter Lambda Boo classification criteria, we concluded that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  14. Healing of surgical wounds made with lambda970-nm diode laser associated or not with laser phototherapy (lambda655 nm) or polarized light (lambda400-2000 nm).

    PubMed

    Medeiros, Juliana L; Nicolau, Renata A; Nicola, Ester M D; dos Santos, Jean N; Pinheiro, Antonio L B

    2010-08-01

    The aim of this study was to analyze the effect of two phototherapies, laser and polarized light, on diode laser (970lambda nm) wounds. Lasers have been used in surgery, and some wavelengths may cause thermal damage to the tissue and affect healing. Several studies have shown that some wavelengths are effective in improving healing. Coherent and noncoherent light have been successfully used on the modulation of biological phenomena of several origins. Thirty-one Wistar rats were divided into 3 groups (GI to GIII). A 20-mm x 2-mm wound was created on the dorsum of each animal with a diode laser (Sirolaser, Sirona, Bensheim, Germany). Group GI acted as control. On GII, laser light (lambda655 nm, 30 mW, phi approximately 3 mm, 12 J/cm(2)) was used and on GIII illumination with polarized light (lambda400-2000 nm, 40 mW, phi approximately 5.5 cm, 12 J/cm(2)) was used, every other day (GII) or daily (GIII) for 7 days. The animals were killed at 0, 7, and 14 days after surgery. Specimens were taken, routinely processed, stained and imunnomarked [HE (hematoxylin-eosin), sirius red, alpha-smooth muscle actin (SMA)], and underwent histological analysis. GII showed better response at day 14 when re-epithelialization was in a more advanced stage. The number of myofibroblasts was significantly different over the healing time (7 to 14 days); this number was smaller than that observed on G1. On GIII at day 7, the number of myofibroblasts was significantly higher than for GII. At day 14, a more pronounced deposition of collagen matrix was also seen, and inflammation was discrete and more advanced for GIII. The results of the present study showed that the effect of the use of laser light was more evident at early stages of healing and that the use of polarized light improved the resolution of the inflammatory reaction, increased the deposition of collagen, increased the number of myofibroblasts, and quickened re-epithelialization during the experimental time.

  15. Longitudinal Spin Transfer to Lambda and Anti-Lambda Hyperons Produced in Polarized Proton-Proton Collisions at Center of Mass Energy = 200 GeV

    NASA Astrophysics Data System (ADS)

    Cendejas, Ramon

    Studies on the spin structure of the proton have been an active area of research; after the EMC experiment and subsequent experiments found that only about 30% of the total proton spin is carried by quark spins. The Relativistic Heavy Ion Collider (RHIC) is the world's first and only polarized proton collider. The Solenoidal Tracker At RHIC (STAR) has full azimuthal acceptance and is ideally suited to advance studies of the proton spin. The longitudinal spin transfer, DLL, of lambda and anti-lambda hyperons in longitudinally polarized proton-proton collisions is sensitive to quark and anti-quark polarization in the polarized proton; as well as to polarized fragmentation; and has been proposed as a possible probe of (anti-)strange quark polarization. The STAR collaboration has previously reported an initial proof-of-concept measurement of DLL of lambda and anti-lambda hyperons from a data sample obtained at sqr(s)=200 GeV in 2005. The data correspond to an integrated luminosity of 2 pb- with 50% beam polarization. Considerably larger data samples corresponding to 6.5 pb- and 25 pb- with beam polarizations of 57% at sqr(s)=200 GeV were obtained in 2006 and 2009 using an upgraded instrument. Improvements were made on the analysis procedure to reduce background contribution to the lambda + anti-lambda measurements. These new measurements of DLL form the main topic of this dissertation. The sample of hyperons residing within a jet that triggered the experiment are classified as near-side hyperons, and are analyzed separately from an away-side sample that has similar precision. In addition to DLL, the double longitudinal spin asymmetry, A LL, for the production of lambda and anti-lambda hyperons has been extracted. The dependences of DLL on pseudo-rapidity, pT , and the fragmentation ratio, z, are studied. The stated DLL from lambda and anti-lambda each disfavor one of the published model predictions for DLL for a combined lambda and anti-lambda sample, and are

  16. UTILIZING SYNTHETIC UV SPECTRA TO EXPLORE THE PHYSICAL BASIS FOR THE CLASSIFICATION OF LAMBDA BOÖTIS STARS

    SciTech Connect

    Cheng, Kwang-Ping; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind; Neff, James E.; Steele, Patricia A.; Gray, Richard O.; Corbally, Christopher J.

    2016-04-15

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  17. Utilizing Synthetic UV Spectra to Explore the Physical Basis for the Classification of Lambda Boötis Stars

    NASA Astrophysics Data System (ADS)

    Cheng, Kwang-Ping; Neff, James E.; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind; Steele, Patricia A.; Gray, Richard O.; Corbally, Christopher J.

    2016-04-01

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  18. Inhibitory effect of tocotrienol on eukaryotic DNA polymerase {lambda} and angiogenesis

    SciTech Connect

    Mizushina, Yoshiyuki . E-mail: mizushin@nutr.kobegakuin.ac.jp; Nakagawa, Kiyotaka; Shibata, Akira; Awata, Yasutoshi; Kuriyama, Isoko; Shimazaki, Noriko; Koiwai, Osamu; Uchiyama, Yukinobu; Sakaguchi, Kengo; Miyazawa, Teruo; Yoshida, Hiromi

    2006-01-20

    Tocotrienols, vitamin E compounds that have an unsaturated side chain with three double bonds, selectively inhibited the activity of mammalian DNA polymerase {lambda} (pol {lambda}) in vitro. These compounds did not influence the activities of replicative pols such as {alpha}, {delta}, and {epsilon}, or even the activity of pol {beta} which is thought to have a very similar three-dimensional structure to the pol {beta}-like region of pol {lambda}. Since {delta}-tocotrienol had the strongest inhibitory effect among the four ({alpha}- to {delta}-) tocotrienols, the isomer's structure might be an important factor in the inhibition of pol {lambda}. The inhibitory effect of {delta}-tocotrienol on both intact pol {lambda} (residues 1-575) and a truncated pol {lambda} lacking the N-terminal BRCA1 C-terminus (BRCT) domain (residues 133-575, del-1 pol {lambda}) was dose-dependent, with 50% inhibition observed at a concentration of 18.4 and 90.1 {mu}M, respectively. However, del-2 pol {lambda} (residues 245-575) containing the C-terminal pol {beta}-like region was unaffected. Tocotrienols also inhibited the proliferation of and formation of tubes by bovine aortic endothelial cells, with {delta}-tocotrienol having the greatest effect. These results indicated that tocotrienols targeted both pol {lambda} and angiogenesis as anti-cancer agents. The relationship between the inhibition of pol {lambda} and anti-angiogenesis by {delta}-tocotrienol was discussed.

  19. An improved lambda-scheme for one-dimensional flows

    NASA Technical Reports Server (NTRS)

    Moretti, G.; Dipiano, M. T.

    1983-01-01

    A code for the calculation of one-dimensional flows is presented, which combines a simple and efficient version of the lambda-scheme with tracking of discontinuities. The latter is needed to identify points where minor departures from the basic integration scheme are applied to prevent infiltration of numerical errors. Such a tracking is obtained via a systematic application of Boolean algebra. It is, therefore, very efficient. Fifteen examples are presented and discussed in detail. The results are exceptionally good. All discontinuites are captured within one mesh interval.

  20. {Lambda}CDM universe in f(R) gravity

    SciTech Connect

    Dunsby, Peter K. S.; Elizalde, Emilio; Saez-Gomez, Diego; Goswami, Rituparno; Odintsov, Sergei

    2010-07-15

    Several different explicit reconstructions of f(R) gravity are obtained from the background Friedmann-Laimatre-Robertson-Walker expansion history. It is shown that the only theory whose Lagrangian is a simple function of the Ricci scalar R, that admits an exact {Lambda}CDM expansion history, is standard general relativity with a positive cosmological constant and the only way to obtain this behavior of the scale factor for more general functions of R is to add additional degrees of freedom to the matter sector.

  1. GAS CLUMPING IN THE OUTSKIRTS OF {Lambda}CDM CLUSTERS

    SciTech Connect

    Nagai, Daisuke; Lau, Erwin T.

    2011-04-10

    Recent Suzaku X-ray observations revealed that the observed entropy profile of the intracluster medium (ICM) deviates significantly from the prediction of hydrodynamical simulations of galaxy clusters. In this work, we show that gas clumping introduces significant biases in X-ray measurements of the ICM profiles in the outskirts of galaxy clusters. Using hydrodynamical simulations of galaxy cluster formation in a concordance {Lambda}CDM model, we demonstrate that gas clumping leads to an overestimate of the observed gas density and causes flattening of the entropy profile. Our results suggest that gas clumping must be taken into account when interpreting X-ray measurements of cluster outskirts.

  2. Radiative decays of the Sigma0(1385) and Lambda(1520) hyperons

    SciTech Connect

    Simon Taylor; Gordon Mutchler; CLAS Collaboration

    2005-03-01

    The electromagnetic decays of the {Sigma}{sup 0}(1385) and {Lambda}(1520) hyperons were studied in photon-induced reactions {gamma} p {yields} K{sup +} {Lambda}(1116){gamma} in the CLAS detector at the Thomas Jefferson National Accelerator Facility. We report the first observation of the radiative decay of the {Sigma}{sup 0}(1385) and a measurement of the {Lambda}(1520) radiative decay width. For the {Sigma}{sup 0}(1385) {yields} {Lambda}(1116){gamma} transition, we measured a partial width of 479 {+-} 120(stat){sub -100}{sup +81}(sys) keV, larger than all of the existing model predictions. For the {Lambda}(1520) {yields} {Lambda}(1116){gamma} transition, we obtained a partial width of 167 {+-} 43(stat){sub -12}{sup +26}(sys) keV.

  3. Measurements of Lambda{sub c}{sup +} Branching Fractions of Cabibbo-Suppressed Decay Modes.

    SciTech Connect

    Saleem, Muhammad

    2004-08-10

    The authors have measured the branching fractions of the Cabibbo-suppressed decays {Lambda}{sub c}{sup +} --> {Lambda}{sup 0}K{sup +} and {Lambda}{sub c}{sup +} --> {Sigma}{sup 0}K{sup +} relative to the Cabibbo-allowed decay modes {Lambda}{sub c}{sup +} --> {Lambda}{sup 0}{pi}{sup +} and {Lambda}{sub c}{sup +} --> {Sigma}{sup 0}{pi}{sup +} to be 0.044 {+-} 0.004 (stat.) {+-} 0.002 (syst.) and 0.040 {+-} 0.005 (stat.) {+-} 0.004 (syst.), respectively. They also present the first observation of {Lambda}{sub c}{sup +} --> {Lambda}{sup 0}K{sup +}{pi}{sup +}{pi}{sup -} and have measured the branching fraction relative to {Lambda}{sub c}{sup +} --> {Lambda}{sup 0}{pi}{sup +} to be 0.266 {+-} 0.027 (stat.) {+-} 0.032 (syst.). The upper limit of the branching fraction into the decay {Lambda}{sub c}{sup +} --> {Sigma}{sup 0}K{sup +}{pi}{sup +}{pi}{sup -} relative to {Lambda}{sub c}{sup +} --> {Sigma}{sup 0}{pi}{sup +} has been measured to be < 3.9 x 10{sup -2} at the 90% confidence level. This analysis was performed using a data sample of 125 fb{sup -1} (integrated luminosity) collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at the Stanford Linear Accelerator Center. All results presented in this contribution are preliminary.

  4. ON THE COMPLETENESS AND QUASIPOWER BASIS PROPERTY OF SYSTEMS \\{z^nf(\\lambda_nz)\\}

    NASA Astrophysics Data System (ADS)

    Oskolkov, V. A.

    1990-02-01

    This paper discusses questions of completeness and the quasipower property in spaces A_R of systems of functions \\{z^nf(\\lambda_nz)\\} under some natural conditions on the Taylor coefficients of the function f(z), assumed regular in a disk \\vert z\\vert. The complex numbers \\lambda_n ( n=0,1,\\dots) are subject to the condition \\vert\\lambda_n\\vert\\leqslant1. Bibliography: 8 titles.

  5. Approximating the Poisson Scan and (lambda-sigma) Acoustic Detection Model with the Random Search Formula

    DTIC Science & Technology

    2009-12-01

    of area search with acoustic sensors modeled by the Poisson Scan model and the Lambda-Sigma model. Detection time results are compared to those...MATLAB simulation of area search with acoustic sensors modeled by the Poisson Scan model and the Lambda-Sigma  model. Detection time results are...study, the author develops a MATLAB simulation of area search with acoustic sensors modeled by the Poisson Scan and the Lambda-Sigma  models. Both

  6. Detection of single lambda DNA fragments by flow cytometry

    SciTech Connect

    Johnson, M.E.; Goodwin, P.M.; Ambrose, W.P.; Martin, J.C.; Marrone, B.L.; Keller, R.A. )

    1993-01-01

    The authors have demonstrated flow cytometric detection and sizing of single pieces of fluorescently stained lambda DNA (48.5 kb) and individual Kpn I restriction fragments of lambda DNA at 17.05 kb and 29.95 kb. DNA fragments were stained stoichiometrically with an intercalating dye such that the fluorescence from each fragment was directly proportional to fragment length. Laser powers range from 10 to 100 mW and transit times through the focused laser beam were several milliseconds. Measurements were made using time-resolved single photon counting of the detected fluorescence emission from individual stained DNA fragments. Samples were analyzed at rates of about 50 fragments per second. The measured fluorescence intensities are linearly correlated with DNA fragment length over the range measured. Detection sensitivity and resolution needed for analysis of small pieces of DNA are discussed and a comparison of single photon counting measurements of DNA fragments to measurements using more conventional flow cytometers is made. Applications of this methodology to DNA sizing and DNA fingerprinting are discussed.

  7. ASTEROSEISMOLOGICAL MODELING OF THE MULTIPERIODIC {lambda} BOOTIS STAR 29 CYGNI

    SciTech Connect

    Casas, R.; Moya, A.; Martin-Ruiz, S.; Amado, P. J.; Garrido, R.; Suarez, J. C.; Rodriguez-Lopez, C

    2009-05-20

    The present work focuses on the discussion of the {lambda} Bootis nature of the multiperiodic {delta} Scuti star HD 192640 (29 Cyg), through a comprehensive asteroseismic modeling. Some of the most recent asteroseismic tools are used to check whether the observed low metallicity is internal, i.e., intrinsic, present throughout the star, or due to superficial processes as accretion, diffusive settling, radiative levitation, mass loss, etc. The modeling method uses some of the most recent tools, including: (1) effects of rotation on equilibrium models, on the adiabatic oscillation spectrum, and its influence in multicolor observables, (2) nonadiabatic stability of radial and nonradial modes, (3) inclusion of the atmosphere-pulsation interaction for a more accurate multicolor mode identification, and (4) ratio between radial modes n = 4 and n = 5 in the framework of Petersen diagrams. The analysis performed reveals that the models fulfilling all the constraints are those in the middle of the main sequence (MS), with subsolar metallicity, except some other unlikely possibilities. Therefore, this study does not support the idea of the {lambda} Bootis stars being zero-age MS or pre-MS stars interacting with their primordial cloud of gas and dust, but suggest the explanation of their nature as submetallic MS objects. Nevertheless, more accurate multicolor photometric observations are required for a more conclusive study using the procedure presented here, since the observational errors are too large for a definitive rejection of any of the possible explanations.

  8. Degradation of lambda-carrageenan by Pseudoalteromonas carrageenovora lambda-carrageenase: a new family of glycoside hydrolases unrelated to kappa- and iota-carrageenases.

    PubMed

    Guibet, Marion; Colin, Sébastien; Barbeyron, Tristan; Genicot, Sabine; Kloareg, Bernard; Michel, Gurvan; Helbert, William

    2007-05-15

    Carrageenans are sulfated galactans found in the cell walls of red seaweeds. They are classified according to the number and the position of sulfate ester groups. lambda-Carrageenan is the most sulfated carrageenan and carries at least three sulfates per disaccharide unit. The sole known depolymerizing enzyme of lambda-carrageenan, the lambda-carrageenase from Pseudoalteromonas carrageenovora, has been purified, cloned and sequenced. Sequence analyses have revealed that the lambda-carrageenase, referred to as CglA, is the first member of a new family of GHs (glycoside hydrolases), which is unrelated to families GH16, that contains kappa-carrageenases, and GH82, that contains iota-carrageenases. This large enzyme (105 kDa) features a low-complexity region, suggesting the presence of a linker connecting at least two independent modules. The N-terminal region is predicted to fold as a beta-propeller. The main degradation products have been purified and characterized as neo-lambda-carratetraose [DP (degree of polymerization) 4] and neo-lambda-carrahexaose (DP6), indicating that CglA hydrolyses the beta-(1-->4) linkage of lambda-carrageenan. LC-MALLS (liquid chromatography-multi-angle laser light scattering) and (1)H-NMR monitoring of the enzymatic degradation of lambda-carrageenan indicate that CglA proceeds according to an endolytic mode of action and a mechanism of inversion of the anomeric configuration. Using 2-aminoacridone-labelled neo-lambda-carrabiose oligosaccharides, in the present study we demonstrate that the active site of CglA comprises at least 8 subsites (-4 to +4) and that a DP6 oligosaccharide binds in the subsites -4 to +2 and can be hydrolysed into DP4 and DP2.

  9. Lambda production in electron-positron annihilation at 29 GeV

    SciTech Connect

    Baden, A.R.

    1986-08-01

    The inclusive cross-secton for the production of the singly-strange baryons lambda and anti lambda, along with the differential cross-sections in momentum and energy, are measured by e/sup +/e/sup -/ annihilation at a center-of-mass energy of 29GeV. The charged decay mode lambda ..-->.. p..pi.. is used in a search for polarization. Such a polarization may be used as a check of CP invariance in lambda production. The sample of events with two detected decays is analyzed for correlations in production angle. 43 refs., 44 figs.

  10. Circular dimers of a lambda DNA in infected, nonlysogenic Escherichia coli.

    PubMed

    Freifelder, D; Baran, N; Folkmanis, A; Freifelder, D L

    1977-09-01

    Covalently closed circular dimers of phage lambda DNA have been found in Escherichia coli infected with lambda. These dimers can be formed by either the lambda Red or Int systems, by a nonrecombinational replicative mechanism requiring the activity of the lambda O and P genes or by joining of the cohesive ends. Dimers mediated by the E. coli Rec system have not been observed. Those formed by the Int system often result from recombination between different DNA molecules; however, the Red-mediated dimers may be a result of replicative extension of a single DNA molecule. Trimers have also been observed but studied only briefly.

  11. Direct and general selection for lysogens of Escherichia coli by phage lambda recombinant clones.

    PubMed

    Henry, M F; Cronan, J E

    1991-06-01

    We report a simple in vivo technique for introducing an antibiotic resistance marker into phage lambda. This technique could be used for direct selection of lysogens harboring recombinant phages from the Kohara lambda bank (a collection of ordered lambda clones carrying Escherichia coli DNA segments). The two-step method uses homologous recombination and lambda DNA packaging to replace the nonessential lambda DNA lying between the lysis genes and the right cohesive (cos) end with the neomycin phosphotransferase (npt) gene from Tn903. This occurs during lytic growth of the phage on a plasmid-containing host strain. Neomycin-resistant (npt+) recombinant phages are then selected from the lysates containing the progeny phage by transduction of a polA1 lambda lysogenic host strain to neomycin resistance. We have tested this method with two different Kohara lambda phage clones; in both cases, neomycin resistance cotransduced with the auxotrophic marker carried by the lambda clone, indicating complete genetic linkage. Linkage was verified by restriction mapping of purified DNA from a recombinant phage clone. We also demonstrate that insertion of the npt+ recombinant phages into the lambda prophage can be readily distinguished from insertion into bacterial chromosomal sequences.

  12. Measurement of the lifetimes of the charmed D/sup +/, F/sup +/ mesons and. lambda. /sub c//sup +/ charmed baryon

    SciTech Connect

    Errede, Steven Michael

    1981-01-01

    An experiment was performed in the 350 GeV wide-band neutrino beam at the Fermi National Accelerator Laboratory using a high-precision, high-efficiency hybrid emulsion/neutrino spectrometer, with which the mean lifetimes of the D/sup +/, D/sup 0/, and F/sup +/ mesons and ..lambda../sub c//sup +/ baryon were measured. 1829 neutrino interactions were reconstructed with a vertex within the emulsion fiducial volume, 1242 of which were subsequently found in the emulsion. In 49 of the found neutrino events a charmed particle, produced at the primary vertex, was observed to decay within the emulsion volume. The mean lifetimes of charmed particles were determined from the reconstructed decays of 5 D/sup +/, 15 D/sup 0/, 3 F/sup +/ mesons: and 8 ..lambda../sub c//sup +/ baryons: tau/sub D/sup +// = 10.3/sub -4.2//sup +10.3/ x 10/sup -13/ sec; tau/sub D/sup 0// = 2.3/sub -0.5//sup +0.8/ x 10/sup -13/ sec; tau/sub f/sup +// = 2.0/sub -0.8//sup +1.8/ x 10/sup -13/ sec; and tau/sub ..lambda..//sub c//sup +/ = 2.3/sub -0.6//sup +1.0/ x 10/sup -13/ sec. The charmed particle masses measured in this experiment were: M/sub D/sup +// = 1851 +- 20 MeV/c/sup 2/; M/sub D/sup 0// = 1856 +- 15 MeV/c/sup 2/; M/sub F/sup +// = 2042 +- 33 MeV/c/sup 2/; M/sub ..lambda..//sub c//sup +/ = 2265 +- 30 MeV/c/sub 2/.

  13. Measurement of the Lambda_b Lifetime in Lambda_b -> Lambda_c+ pi- Decays in p-pbar Collisions at sqrt(s) = 1.96 TeV

    SciTech Connect

    Aaltonen, T.; Adelman, J.; Alvarez Gonzalez, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; /Waseda U. /Dubna, JINR

    2009-12-01

    We report a measurement of the lifetime of the {Lambda}{sub b}{sup 0} baryon in decays to the {Lambda}{sub c}{sup +} {pi}{sup -} final state in a sample corresponding to 1.1 fb{sup -1} collected in p{bar p} collisions at {radical}s = 1.96 TeV by the CDF II detector at the Tevatron collider. Using a sample of about 3000 fully reconstructed {Lambda}{sub b}{sup 0} events we measure {tau}({Lambda}{sub b}{sup 0}) = 1.401 {+-} 0.046 (stat) {+-} 0.035 (syst) ps (corresponding to c{tau}({Lambda}{sub b}{sup 0}) = 420.1 {+-} 13.7 (stat) {+-} 10.6 (syst) {micro}m, where c is the speed of light). The ratio of this result and the world average B{sup 0} lifetime yields {tau}({Lambda}{sub b}{sup 0})/{tau}(B{sup 0}) = 0.918 {+-} 0.038 (stat and syst), in good agreement with recent theoretical predictions.

  14. Simultaneous observations of the He I lambda 1083 and lambda 587.6 lines in the solar atmosphere

    NASA Astrophysics Data System (ADS)

    Andretta, V.

    1996-05-01

    Helium lines are generally a valuable tool to trace activity in the solar atmosphere. The most prominent lines observable from ground-based observatories are the triplet lines at 587.6 and 1083 nm, but despite the wide use of these activity tracer (especially of the latter), little progress has been made towards the exploitation of their diagnostic potential. However, recent theoretical investigations have pointed out that of correlation between the two main triplet He I lines can discriminate between different scenarios of the line formation, ultimately giving informations on the structure of the upper chromosphere/lower transition region. The observations presented here address such issues for the first time. The spectra were obtained with the FTS at the McMath/Pierce telescope on Kitt Peak; they constitute in fact a set of simultaneous observations of the two lines for several solar features. The observed joint response of lambda 587.6 and lambda 1083 to the level of chromospheric heating can thus be directly compared with theoretical predictions.

  15. OT1_hmaness_1: Planets, Debris Disks, and the Lambda Bootis Stars

    NASA Astrophysics Data System (ADS)

    Maness, H.

    2010-07-01

    We propose to explore the link between lambda Bootis stars, debris disks, and planetesimal formation and evolution. The lambda Boo stars are a rare type of peculiar A star (2%), which are Population 1 and metal poor. Planet bearing systems and debris disk stars appear unusually well represented in the lambda Boo class: for example, beta Pic, Vega, and HR 8799 are all lambda Boo candidates. A small sample of 14 lambda Boo stars observed by Spitzer suggests an occurrence of infrared excess approaching 100%. Only two lambda Boo stars are included in the DEBRIS/DUNES Herschel key program debris disk surveys. We will use PACS/Herschel to make sensitive, high-resolution maps of 27 new lambda Boo stars. Like DEBRIS/DUNES, we will reach the stellar photosphere for all targets, enabling a measurement of the true rate of excess infrared emission among lambda Boo stars compared to normal A stars. The depletion pattern of heavy elements in the atmospheres of lambda Boo stars suggests they may have accreted gas from which dust grains have condensed and been removed: this gas may be circumstellar gas that has formed planetesimals or dusty interstellar gas. While the circumstellar disk scenario predicts sizes of a few hundred AU, the cloud accretion scenario predicts 1000-2000 AU bow structures oriented in the direction of the relative motion of the cloud and star. With target distances of < 140 pc, these bow structures are expected to be resolved for all targets. These will be the first mid-infrared observations of lambda Boo stars outside of the low density Local Bubble: if interstellar medium interactions dominate the lambda Boo phenomenon then systematic variations in excess strength and morphology may occur with distance.

  16. AL amyloidosis with IgD-lambda monoclonal gammopathy and lambda-type Bence-Jones protein: successful treatment by autologous stem cell transplantation.

    PubMed

    Sakurai-Chin, Chanhyok; Ubara, Yoshifumi; Suwabe, Tatsuya; Hoshino, Junichi; Yonaha, Tomoki; Hasegawa, Eiko; Sumida, Keiichi; Hiramatsu, Rikako; Yamanouchi, Masayuki; Hayami, Noriko; Yamauchi, Junji; Tominaga, Naoyuki; Sawa, Naoki; Takemoto, Fumi; Masuoka, Kazuhiro; Takaichi, Kenmei; Oohashi, Kenichi

    2010-10-01

    A 45-year-old Japanese woman had been diagnosed with monoclonal gammopathy of undetermined significance (MGUS) featuring urinary Bence-Jones protein of the lambda type (BJP-lambda) for 11 years. She then developed eyelid purpura, dyspnea, and flank pain. Abdominal CT scans revealed renal infarction. Biopsy of the kidney, heart, jejunum, and skin demonstrated amyloid deposits in the vessel walls, but not in the glomeruli. She was diagnosed as having AL amyloidosis with IgD-lambda monoclonal gammopathy and BJP-lambda. Autologous stem cell transplantation (SCT) was done after chemotherapy with vincristine, daunorubicin, dexamethasone (VAD), and high-dose melphalan (HDM). This reduced the IgD level from 156 to 0.1 mg/dL, along with the disappearance of BJP, despite cerebral infarction during chemotherapy. We recommend SCT for patients with IgD-associated AL amyloidosis.

  17. Longitudinal Spin Transfer to Lambda and Lambda bar Hyperons in Polarized Proton-Proton Collisions at sqrt s = 200 GeV

    SciTech Connect

    STAR Collaboration; Abelev, Betty

    2010-07-05

    The longitudinal spin transfer, D{sub LL}, from high energy polarized protons to {Lambda} and {bar {Lambda}} hypersons has been measured for the first time in proton-proton collisions at {radical}s = 200 GeV with the STAR detector at RHIC. The measurements cover pseudorapidity, {eta}, in the range |{eta}| < 1.2 and transverse momenta, p{sub T}, up to 4 GeV/c. The longitudinal spin transfer is found to be D{sub LL} = -0.03{+-}0.13(stat){+-}0.04(syst) for inclusive {Lambda} and D{sub LL} = -0.12{+-}0.08(stat){+-}0.03(syst) for inclusive {bar {Lambda}} hyperons with <{eta}> = 0.5 and = 3.7 GeV/c. The dependence on {eta} and p{sub T} is presented.

  18. [A case of lambda-expressing pulmonary MALT lymphoma with dual clonal rearrangements of kappa and lambda immunoglobulin light chain gene].

    PubMed

    Oh, Hye Ryong; Lee, Mi Ja; Park, Geon; Moon, Dae Soo; Park, Young Jin; Jang, Sook Jin

    2009-06-01

    A 70-yr-old woman was hospitalized with a history of dry cough. Bronchial endoscopy and transbronchial lung biopsy were performed. However, the findings of histopathology and immunohistochemistry were not sufficient to decide whether the lesion was benign or malignant, because of the presence of crush artifacts in the biopsy specimens. We performed B-cell clonality studies using BIOMED-2 multiplex PCR (InVivoScribe Technologies, USA) to detect clonal rearrangements in the immunoglobulin gene. The results of multiplex PCR showed clonal rearrangements of both kappa and lambda immunoglobulin light chain genes. The findings of immunochemistry revealed that the lesion expressed lambda light chain, but not kappa light chain. Based on the clinical, pathologic, and molecular findings, this case was diagnosed as pulmonary MALT lymphoma. We report the first case in Korea of lambda-expressing MALT lymphoma that is shown to have dual clonal rearrangements of kappa and lambda immunoglobulin light chain gene by multiplex PCR.

  19. Vortex Loops at the Superfluid Lambda Transition: An Exact Theory?

    NASA Technical Reports Server (NTRS)

    Williams, Gary A.

    2003-01-01

    A vortex-loop theory of the superfluid lambda transition has been developed over the last decade, with many results in agreement with experiments. It is a very simple theory, consisting of just three basic equations. When it was first proposed the main uncertainty in the theory was the use Flory scaling to find the fractal dimension of the random-walking vortex loops. Recent developments in high-resolution Monte Carlo simulations have now made it possible to verify the accuracy of this Flory-scaling assumption. Although the loop theory is not yet rigorously proven to be exact, the Monte Carlo results show at the least that it is an extremely good approximation. Recent loop calculations of the critical Casimir effect in helium films in the superfluid phase T < Tc will be compared with similar perturbative RG calculations in the normal phase T > Tc; the two calculations are found to match very nicely right at Tc.

  20. Spectral diagnostics of high energy emission in lambda Eri

    NASA Technical Reports Server (NTRS)

    Smith, Myron

    1995-01-01

    Multi-line observations of the optical spectrum of lambda Eri demonstrates that rapidly varying, low-velocity emissions occur in several He I lines even when H alpha shows no emission. A peculiar aspect of the He I emissions is that the ratio 5876/6678 is = 1. A theory of helium line formation generally admits two common emission mechanisms. The first is recombination/cascades, which is well known to give a ratio of greater than or equal to 3. The second is a non-LTE effect that occurs in hot (O-type) photospheres when resonance He I 584 radiation becomes transparent and drives single lines along into the emission. To accommodate a ratio of 5876/6678 = 1 may require that both processes sometimes operate at the same time, presumably in separate localities near the surface of this star.

  1. The Ba II [lambda]4554 resonance line and solar granulation

    NASA Astrophysics Data System (ADS)

    Olshevsky, V. L.; Shchukina, N. G.

    We present the results of an investigation of the impact of NLTE effects and of granulation inhomogeneities on the solar Ba II [lambda]4554 Å line. Our analysis is based on both the classical one-dimensional (1D) solar atmosphere models and on the new generation of three-dimensional (3D) hydrodynamical models. We show that NLTE and 3D effects have to be taken into account for reliable diagnostics of the solar atmosphere using this line. We analyse the influence of different parameters on the line shape. It turns out to be most sensitive to collisional broadening and barium abundance. Uncertainties in the oscillator strength, micro- and macroturbulence (in 1D-case) have a secondary importance. We have derived the barium abundance assuming NLTE. We find ABa = 2.16 in good agreement with the recent result of Asplund et al. (2005).

  2. A Lambda 1400 spectrophotometric census of the Orion belt region

    NASA Technical Reports Server (NTRS)

    Brown, Douglas N.; Shore, Steven N.

    1986-01-01

    Low dispersion IUE spectrophotometry were used to generate a pair of photometric indices which measure the strength of the broad continuum absorption feature at 1400 A, likely an autoionizing transition of Si II. Calibration of the indices as identifiers of silicon overabundance is based on measurements of 25 IUE spectral standards and a sample of O8-A0 IV-V stars, 18 of them silicon stars. The correlations of delta alpha 1400 with delta alpha 5200 and delta (VI-G) support the association of the lambda 5200 feature with silicon. Using this technique, a magnitude limited survey of 28 B-stars in sub-groups b1, b2 and b3 of the Orion OB1 association was conducted. Two previously unrecognized candidate (perhaps weakly overabundant) silicon stars, HD 37187 and BD - 0 deg 984 are identified.

  3. Vortex Loops at the Superfluid Lambda Transition: An Exact Theory?

    NASA Technical Reports Server (NTRS)

    Williams, Gary A.

    2003-01-01

    A vortex-loop theory of the superfluid lambda transition has been developed over the last decade, with many results in agreement with experiments. It is a very simple theory, consisting of just three basic equations. When it was first proposed the main uncertainty in the theory was the use Flory scaling to find the fractal dimension of the random-walking vortex loops. Recent developments in high-resolution Monte Carlo simulations have now made it possible to verify the accuracy of this Flory-scaling assumption. Although the loop theory is not yet rigorously proven to be exact, the Monte Carlo results show at the least that it is an extremely good approximation. Recent loop calculations of the critical Casimir effect in helium films in the superfluid phase T < Tc will be compared with similar perturbative RG calculations in the normal phase T > Tc; the two calculations are found to match very nicely right at Tc.

  4. Directed evolution of nucleotide-based libraries using lambda exonuclease.

    PubMed

    Lim, Bee Nar; Choong, Yee Siew; Ismail, Asma; Glökler, Jörn; Konthur, Zoltán; Lim, Theam Soon

    2012-12-01

    Directed evolution of nucleotide libraries using recombination or mutagenesis is an important technique for customizing catalytic or biophysical traits of proteins. Conventional directed evolution methods, however, suffer from cumbersome digestion and ligation steps. Here, we describe a simple method to increase nucleotide diversity using single-stranded DNA (ssDNA) as a starting template. An initial PCR amplification using phosphorylated primers with overlapping regions followed by treatment with lambda exonuclease generates ssDNA templates that can then be annealed via the overlap regions. Double-stranded DNA (dsDNA) is then generated through extension with Klenow fragment. To demonstrate the applicability of this methodology for directed evolution of nucleotide libraries, we generated both gene shuffled and regional mutagenesis synthetic antibody libraries with titers of 2×108 and 6×107, respectively. We conclude that our method is an efficient and convenient approach to generate diversity in nucleic acid based libraries, especially recombinant antibody libraries.

  5. Genomic variation in the porcine immunoglobulin lambda variable region

    PubMed Central

    Guo, Xi; Schwartz, John C.; Murtaugh, Michael P.

    2016-01-01

    Production of a vast antibody repertoire is essential for protection against pathogens. Variable region germline complexity contributes to repertoire diversity and is a standard feature of mammalian immunoglobulin loci, but functional V region genes are limited in swine. For example, the porcine lambda light chain locus is composed of 23 variable (V) genes and 4 joining (J) genes, but only 10 or 11 V and 2 J genes are functional. Allelic variation in V and J may increase overall diversity within a population, yet lead to repertoire holes in individuals lacking key alleles. Previous studies focused on heavy chain genetic variation, thus light chain allelic diversity is not known. We characterized allelic variation of the porcine immunoglobulin lambda variable (IGLV) region genes. All intact IGLV genes in 81 pigs were amplified, sequenced, and analyzed to determine their allelic variation and functionality. We observed mutational variation across the entire length of the IGLV genes, in both framework and complementarity determining regions (CDRs). Three recombination hotspots were also identified, suggesting that non-allelic homologous recombination is an evolutionarily alternative mechanism for generating germline antibody diversity. Functional alleles were greatest in the most highly expressed families, IGLV3 and IGLV8. At the population level, allelic variation appears to help maintain the potential for broad antibody repertoire diversity in spite of reduced gene segment choices and limited germline sequence modification. The trade-off may be a reduction in repertoire diversity within individuals that could result in increased variation in immunity to infectious disease and response to vaccination. PMID:26791019

  6. Genomic variation in the porcine immunoglobulin lambda variable region.

    PubMed

    Guo, Xi; Schwartz, John C; Murtaugh, Michael P

    2016-04-01

    Production of a vast antibody repertoire is essential for the protection against pathogens. Variable region germline complexity contributes to repertoire diversity and is a standard feature of mammalian immunoglobulin loci, but functional V region genes are limited in swine. For example, the porcine lambda light chain locus is composed of 23 variable (V) genes and 4 joining (J) genes, but only 10 or 11 V and 2 J genes are functional. Allelic variation in V and J may increase overall diversity within a population, yet lead to repertoire holes in individuals lacking key alleles. Previous studies focused on heavy chain genetic variation, thus light chain allelic diversity is not known. We characterized allelic variation of the porcine immunoglobulin lambda variable (IGLV) region genes. All intact IGLV genes in 81 pigs were amplified, sequenced, and analyzed to determine their allelic variation and functionality. We observed mutational variation across the entire length of the IGLV genes, in both framework and complementarity determining regions (CDRs). Three recombination hotspot motifs were also identified suggesting that non-allelic homologous recombination is an evolutionarily alternative mechanism for generating germline antibody diversity. Functional alleles were greatest in the most highly expressed families, IGLV3 and IGLV8. At the population level, allelic variation appears to help maintain the potential for broad antibody repertoire diversity in spite of reduced gene segment choices and limited germline sequence modification. The trade-off may be a reduction in repertoire diversity within individuals that could result in an increased variation in immunity to infectious disease and response to vaccination.

  7. The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits

    PubMed Central

    Kozlowski, Piotr; Montgomery, Scott; Befekadu, Rahel; Hahn-Strömberg, Victoria

    2017-01-01

    Background Light chain amyloidosis (AL) is a rare deposition disease and is present in 10–15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM). Methods We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD. Results Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively). Conclusion Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD. PMID:28293126

  8. LambdaStation: Exploiting Advance Networks In Data Intensive High Energy Physics Applications

    SciTech Connect

    Harvey B. Newman

    2009-09-11

    Lambda Station software implements selective, dynamic, secure path control between local storage & analysis facilities, and high bandwidth, wide-area networks (WANs). It is intended to facilitate use of desirable, alternate wide area network paths which may only be intermittently available, or subject to policies that restrict usage to specified traffic. Lambda Station clients gain awareness of potential alternate network paths via Clarens-based web services, including path characteristics such as bandwidth and availability. If alternate path setup is requested and granted, Lambda Station will configure the local network infrastructure to properly forward designated data flows via the alternate path. A fully functional implementation of Lambda Station, capable of dynamic alternate WAN path setup and teardown, has been successfully developed. A limited Lambda Station-awareness capability within the Storage Resource Manager (SRM) product has been developed. Lambda Station has been successfully tested in a number of venues, including Super Computing 2008. LambdaStation software, developed by the Fermilab team, enables dynamic allocation of alternate network paths for high impact traffic and to forward designated flows across LAN. It negotiates with reservation and provisioning systems of WAN control planes, be it based on SONET channels, demand tunnels, or dynamic circuit networks. It creates End-To-End circuit between single hosts, computer farms or networks with predictable performance characteristics, preserving QoS if supported in LAN and WAN and tied security policy allowing only specific traffic to be forwarded or received through created path. Lambda Station project also explores Network Awareness capabilities.

  9. Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis.

    PubMed

    Selvaggi, Carla; Pierangeli, Alessandra; Fabiani, Marco; Spano, Lucia; Nicolai, Ambra; Papoff, Paola; Moretti, Corrado; Midulla, Fabio; Antonelli, Guido; Scagnolari, Carolina

    2014-05-01

    The airway expression of type III interferons (IFNs) was evaluated in infants hospitalized for respiratory syncytial virus (RSV) or rhinovirus (HRV) bronchiolitis. As an additional objective we sought to determine whether a different expression of IFN lambda 1-3 was associated with different harboring viruses, the clinical course of bronchiolitis or with the levels of well established IFN stimulated genes (ISGs), such as mixovirus resistance A (MxA) and ISG56. The analysis was undertaken in 118 infants with RSV or HRV bronchiolitis. Nasopharyngeal washes were collected for virological studies and molecular analysis of type III IFN responses. RSV elicited higher levels of IFN lambda subtypes when compared with HRV. A similar expression of type III IFN was found in RSVA or RSVB infected infants and in those infected with HRVA or HRVC viruses. Results also indicate that IFN lambda 1 and IFN lambda 2-3 levels were correlated with each other and with MxA and ISG56-mRNAs. In addition, a positive correlation exists between the IFN lambda1 levels and the clinical score index during RSV infection. In particular, higher IFN lambda 1 levels are associated to an increase of respiratory rate. These findings show that differences in the IFN lambda 1-3 levels in infants with RSV or HRV infections are present and that the expression of IFN lambda 1 correlates with the severity of RSV bronchiolitis. Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  10. Measurement of the Branching Ratio Lambda_c+ -> p pi+ pi-

    SciTech Connect

    Lopez-Hinojosa, Guillermo; /San Luis Potosi U.

    2008-03-01

    The confirmation of the Cabibbo-suppressed charm baryon decay mode {Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -} is reported. All data analyzed are from SELEX, a fixed target experiment at Fermilab that took data during 1996 and 1997, mainly with a 600 GeV/c {Sigma}{sup -} beam. The branching ratio of the Cabibbo-suppressed decay mode {Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -} relative to the Cabibbo-favored mode {Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +} is measured to be: {Gamma}({Lambda}{sub c}{sup +} {yields} p{pi}{sup +}{pi}{sup -})/{Gamma}({Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +}) = 0.103 {+-} 0.022.

  11. Nonlinear collisionless plasma wakes of small particles

    SciTech Connect

    Hutchinson, I. H.

    2011-03-15

    The wake behind a spherical particle smaller than the Debye length ({lambda}{sub De}) in flowing plasma is calculated using a particle-in-cell code. The results with different magnitudes of charge reveal substantial nonlinear effects down to values that for a floating particle would correspond to a particle radius {approx}10{sup -2{lambda}}{sub De}. The peak potential in the oscillatory wake structure is strongly suppressed by nonlinearity, never exceeding {approx}0.4 times the unperturbed ion energy. By contrast, the density peak arising from ion focusing can be many times the ambient. Strong heating of the ions occurs in the nonlinear regime. Direct ion absorption by the particle is not important for the far wake unless the radius exceeds 10{sup -1{lambda}}{sub De}, and is therefore never significant (for the far wake) in the linear regime. Reasonable agreement with full-scale linear response calculations are obtained in the linear regime. The wake wavelength is confirmed and an explanation, in terms of the conical potential structure, is proposed for experimentally-observed oblique alignment of different-sized grains.

  12. a Study of the Decay Properties of the Charmed Baryon Charmed Positive Lambda Baryon

    NASA Astrophysics Data System (ADS)

    Charlesworth, Catriona Elizabeth Kaye

    The charmed baryon Lambda_sp {c}{+} has been observed using the ARGUS detector in the DORIS II e^{+ }e^- storage ring at DESY. The ARGUS experiment is a 4pi magnetic solenoidal detector used to observe e^{+}e ^- annihilations at center-of-mass energies around 10.4 GeV. We have studied 5 decays modes of the Lambda_sp{c}{+}. The decay mode Lambda_sp{c} {+}to pK^-pi^+ was used to measure the Lambda_sp {c}{+} fragmentation properties. A value of 0.24 +/- 0.04 was found for the Peterson et al. parameter epsilon, and the sigma(Lambda_sp{c }{+}) cdot BR( Lambda_sp{c}{+}to pK^-pi^+) was measured to be 12.0 +/- 1.1 +/- 1.3) pb. The decay modes Lambda_sp {c}{+}toLambdapi^+ and Lambda_sp{c} {+}toSigma^0pi^+ were also studied. In the former the asymmetry parameter alpha_{Lambda _{c}} was measured to be -1.0 +/- 0.5, indicating that parity is maximally violated in this decay. The two production cross section times branching ratios were measured to be (2.2 +/- 0.3 +/- 0.3) pb and (2.0 +/- 0.7 +/- 0.3) pb respectively. Finally, a search was made for evidence of W-exchange in the decay Lambda_sp{c}{+} toXi^-K^+pi^+. This final state can arise through a simple spectator decay or via the more exotic W-exchange decay into Xi ^{*0}K^+, where the Xi^{*0} subsequently decays into Xi^-pi^+. The two body rate was measured to be (35 +/- 17)% of the three body rate, indicating that a significant portion of the Xi^-K^+pi ^+ final state may occur via W-exchange.

  13. Holmium:YAG (lambda = 2,120 nm) versus thulium fiber (lambda = 1,908 nm) laser lithotripsy.

    PubMed

    Blackmon, Richard L; Irby, Pierce B; Fried, Nathaniel M

    2010-03-01

    The holmium:YAG laser is currently the most common laser lithotripter. However, recent experimental studies have demonstrated that the thulium fiber laser is also capable of vaporizing urinary stones. The high-temperature water absorption coefficient for the thulium wavelength (mu(a) = 160 cm(-1) at lambda = 1,908 nm) is significantly higher than for the holmium wavelength (mu(a) = 28 cm(-1) at lambda = 2,120 nm). We hypothesize that this should translate into more efficient laser lithotripsy using the thulium fiber laser. This study directly compares stone vaporization rates for holmium and thulium fiber lasers. Holmium laser radiation pulsed at 3 Hz with 70 mJ pulse energy and 220 microseconds pulse duration was delivered through a 100-microm-core silica fiber to human uric acid (UA) and calcium oxalate monohydrate (COM) stones, ex vivo (n = 10 each). Thulium fiber laser radiation pulsed at 10 Hz with 70 mJ pulse energy and 1-millisecond pulse duration was also delivered through a 100-microm fiber for the same sets of 10 stones each. For the same number of pulses and total energy (126 J) delivered to each stone, the mass loss averaged 2.4+/-0.6 mg (UA) and 0.7+/-0.2 mg (COM) for the holmium laser and 12.6+/-2.5 mg (UA) and 6.8+/-1.7 (COM) for the thulium fiber laser. UA and COM stone vaporization rates for the thulium fiber laser averaged 5-10 times higher than for the holmium laser at 70 mJ pulse energies. With further development, the thulium fiber laser may represent an alternative to the conventional holmium laser for more efficient laser lithotripsy.

  14. Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells

    PubMed Central

    Sapinoro, Ramil; Volcy, Ketna; Shanaka, W.W.; Rodrigo, I.; Schlesinger, Jacob J.; Dewhurst, Stephen

    2008-01-01

    Lambda phage vectors mediate gene transfer in cultured mammalian cells and in live mice, and in vivo phage-mediated gene expression is increased when mice are pre-immunized with bacteriophage lambda. We now show that, like eukaryotic viruses, bacteriophage vectors are subject to Fc receptor-mediated, antibody-dependent enhancement of infection in mammalian cells. Antibody-dependent enhancement of phage gene transfer required FcγRI, but not its associated γ chain, and was not supported by other FcγR family members (FcγRIIA, FcγRIIB and FcγRIII). Studies using chlorpromazine and latrunculin A revealed an important role for clathrin-mediated endocytosis (chlorpromazine) and actin filaments (latrunculin A) in antibody-enhanced phage gene transfer. This was confirmed by experiments using inhibitors of endosomal acidification (bafilomycin A1, monensin) and by immunocytochemical colocalization of internalized phage particles with early endosome-associated protein-1 (EAA1) . In contrast, microtubule-targeting agents (nocodazole, taxol) increased the efficiency of antibody-enhanced phage gene transfer. These results reveal an unexpected antibody-dependent, FcγRI-mediated enhancement of phage transduction in mammalian cells, and suggest new approaches to improve bacteriophage-mediated gene transfer. PMID:18191979

  15. Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells.

    PubMed

    Sapinoro, Ramil; Volcy, Ketna; Rodrigo, W W Shanaka I; Schlesinger, Jacob J; Dewhurst, Stephen

    2008-04-10

    Lambda phage vectors mediate gene transfer in cultured mammalian cells and in live mice, and in vivo phage-mediated gene expression is increased when mice are pre-immunized with bacteriophage lambda. We now show that, like eukaryotic viruses, bacteriophage vectors are subject to Fc receptor-mediated, antibody-dependent enhancement of infection in mammalian cells. Antibody-dependent enhancement of phage gene transfer required FcgammaRI, but not its associated gamma-chain, and was not supported by other FcgammaR family members (FcgammaRIIA, FcgammaRIIB, and FcgammaRIII). Studies using chlorpromazine and latrunculin A revealed an important role for clathrin-mediated endocytosis (chlorpromazine) and actin filaments (latrunculin A) in antibody-enhanced phage gene transfer. This was confirmed by experiments using inhibitors of endosomal acidification (bafilomycin A1, monensin) and by immunocytochemical colocalization of internalized phage particles with early endosome-associated protein-1 (EAA1). In contrast, microtubule-targeting agents (nocodazole, taxol) increased the efficiency of antibody-enhanced phage gene transfer. These results reveal an unexpected antibody-dependent, FcgammaRI-mediated enhancement of phage transduction in mammalian cells, and suggest new approaches to improve bacteriophage-mediated gene transfer.

  16. DM/DE revealed: The physical origin of Lambda-CDM

    NASA Astrophysics Data System (ADS)

    Beichler, James

    2009-10-01

    In the past few decades two new `crises' affecting fundamental physics have emerged in the observation of phenomena that indicate the existence of Dark Matter and Dark Energy. These are not problems which can be solved by quantum theory or particles, but rather problems that are related to gravity theory as expressed by the general theory of relativity. Numerous ideas and hypotheses have been suggested to explain these new problematic phenomena, but no particular hypothesis or resulting model has proven satisfactory. No model yet proposed seems to be able to explain either DM and DE or both even though theoretical physicists generally agree that the two should have a single common explanation. There is, however, one relatively unknown exception that can explain both DM and DE without any additional hypotheses and this model explains the physical origins of the Lambda-CDM term that others have already proposed adding to general relativity. Yet this new model is not without consequences for the rest of physics and science: Accepting this new model would mean acknowledging the existence of a higher space-like dimension in addition to our normal four-dimensions of space-time.

  17. Penetration depth lambda(T) of YBa2Cu3O(7-delta) films determined from the kinetic inductance

    NASA Astrophysics Data System (ADS)

    Lee, Juyoung; Lemberger, Thomas R.

    1993-05-01

    We examine the temperature dependence of the magnetic penetration depth lambda(T) of YBa2Cu3O(7-delta), determined from the kinetic inductance of a film patterned into a long meander line. This technique has sufficient sensitivity to study lambda(T) to lower temperatures than have been examined previously. A numerical model which includes both the magnetic and kinetic inductances of the samples extracts lambda(T) from the measured voltage. In reasonable agreement with other measurements, lambda(0) about 2100 A is deduced from fitting lambda(0)-squared/lambda(T)-squared to the function 1 - (T/Tc)-squared for T/Tc greater than 0.4. We find lambda(T)/lambda(0) - 1 is proportional to (T/Tc)-squared for T/Tc between 0.06 and 0.4.

  18. Varying alpha/lambda in NLC Structures--BNS Damping and Emittance Growth(LCC-0063)

    SciTech Connect

    Stupakov, G

    2003-12-03

    In this note we consider the effect of the varying the iris opening {alpha} in the NLC structures on the beam dynamics and the RF efficiency in the linac. The most important consequence of the variation of the iris openings is the change of the longitudinal and transverse wakefields. Wake as a function of parameter {alpha} for the NLC structures has been previously calculated by K. Bane. Here we will use his result for the scalings of the longitudinal wake w{sub l} and transverse wake w{sub t} with the geometrical dimensions of the structure: w{sub l}(s) = Z{sub 0}c/{pi}{alpha}{sup 2} e{radical}(s/s{sub 0}), dw{sub t}(s)/ds = 2Z{sub 0}c/{pi}{alpha}{sup 4} e{sup -} {radical}(s/s{sub 1}) where for the scaling parameters s{sub 0} and s{sub 1} we have s{sub 0} = 0.41 a{sup 1.8}g{sup 1.6}/L{sup 2.4}, s{sub 1} = ({alpha}[m]){sup 1.96}, with g being the distance between the irises (gap) and L - the cell period (equal to the gap plus the iris thickness). The above formulas were derived assuming 2{pi}/3 phase advance between the structure cells. The wakefields were calculated assuming g = 7.09 mm and L = 8.75 mm and four different ratios of {alpha}/{lambda} = 0.18, 0.17, 0.16, 0.15 ({lambda} = 2.62 cm corresponding to the frequency 11.424 GHz). The plots of the longitudinal and transverse wakes are shown in Fig. 1 and 2. The beams dynamics in the NLC lattice (linac.cd1.1.trans) was simulated using the LIAR code for the nominal case with the following parameters: initial beam energy--10 GeV, final beam energy--500 GeV, number of particles in the bunch--10{sup 10}, normalized vertical beam emittance at the entrance to the linac--3 {center_dot} 10{sup -8} m, and the rms bunch length--150 {micro}m.

  19. Searches for the baryon- and lepton-number violating decays $B^0\\rightarrow\\Lambda_c^ \\ell^-$, $B^-\\rightarrow\\Lambda\\ell^-$, and $B^-\\rightarrow\\bar{\\Lambda}\\ell^-$

    SciTech Connect

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Milanes, D.A.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; Koch, H.; Schroeder, T.; /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /Milan U. /Milan U. /Milan U. /Milan U. /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-06-22

    Searches for B mesons decaying to final states containing a baryon and a lepton are performed, where the baryon is either {Lambda}{sub c} or {Lambda} and the lepton is a muon or an electron. These decays violate both baryon and lepton number and would be a signature of physics beyond the standard model. No significant signal is observed in any of the decay modes, and upper limits in the range (3.2 - 520) x 10{sup -8} are set on the branching fractions at the 90% confidence level.

  20. {lambda}{sup 0} Polarization in Exclusive pp Reactions From the FNAL e690 Experiment

    SciTech Connect

    Felix, J.; Berisso, M. C.; Christian, D. C.; Gottschalk, E. E.; Gutierrez, G.; Wang, M. H. L. S.; Wehmann, A.; Gara, A.; Hartouni, E. P.; Knapp, B. C.; Kreisler, M. N.; Lee, S.; Markianos, K.; Moreno, G.; Reyes, M. A.; Wesson, D.

    2009-04-20

    It is an experimental evidence that all baryons are created polarized from unpolarized p-nucleus collisions. So far, the origin of this polarization remains unexplained in spite of the experimental evidences accumulated in the past thirty years. Up to these days, {lambda}{sup 0} is the most studied baryon for polarization, for it is copiously produced in p--nucleus collisions at the energies of the principal high energy physics accelerators of the world. This paper is an overview of the experimental evidences accumulated on the polarization of {lambda}{sup 0} from unpolarized exclusive pp collisions as function of x{sub F}, P{sub T}, and M({lambda}{sup 0}K{sup +}) in the past fifteen years inside Fermilab e690 experiment, in the particular reactions pp{yields}p{lambda}{sup 0}K{sup 0}{pi}{sup +}, pp{yields}pp{lambda}{sup 0}{lambda}{sup -0}, pp{yields}p{lambda}{sup 0}K{sup +}, produced at 800 GeV.

  1. Observation of the baryonic B-decay B0bar -> LambdaC antiproton K- pi

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-10-20

    The authors report the observation of the baryonic B-decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar p}K{sup -}{pi}{sup +}, excluding contributions from the decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar {Lambda}}K{sup -}. Using a data sample of 467 million B{bar B} pairs collected with the BABAR detector at the PEP-II storage ring at SLAC, the measured branching fraction is (4.33 {+-} 0.82){sub stat} {+-} 0.33{sub syst} {+-} 1.13{sub {Lambda}{sub c}{sup +}} x 10{sup -5}. In addition they find evidence for the resonant decay {bar B}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{bar p}K{sup -} and determine its branching fraction to be (1.11 {+-} 0.30{sub stat} {+-} 0.09{sub syst} {+-} 0.29{sub {Lambda}{sub c}{sup +}}) x 10{sup -5}. The errors are statistical, systematic, and due to the uncertainty in the {Lambda}{sub c}{sup +} branching fraction. For the resonant decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar p}{bar K}*{sup 0} we obtain an upper limit of 2.42 x 10{sup -5} at 90% confidence level.

  2. Recombination between bacteriophage lambda and plasmid pBR322 in Escherichia coli.

    PubMed Central

    Pogue-Geile, K L; Dassarma, S; King, S R; Jaskunas, S R

    1980-01-01

    Recombinant lambda phages were isolated that resulted from recombination between the lambda genome and plasmid pBR322 in Escherichia coli, even though these deoxyribonucleic acids (DNAs) did not share extensive regions of homology. The characterization of these recombinant DNAs by heteroduplex analysis and restriction endonucleases is described. All but one of the recombinants appeared to have resulted from reciprocal recombination between a site on lambda DNA and a site on the plasmid. In general, there were two classes of recombinants. One class appeared to have resulted from recombination at the phage attachment site that probably resulted from lambda integration into secondary attachment sites on the plasmid. Seven different secondary attachment sites on pBR322 were found. The other class resulted from plasmid integration at other sites that were widely scattered on the lambda genome. For this second class of recombinants, more than one site on the plasmid could recombine with lambda DNA. Thus, the recombination did not appear to be site specific with respect to lambda or the plasmid. Possible mechanisms for generating these recombinants are discussed. Images PMID:6247334

  3. Characterization of a labile naloxone binding site (lambda site) in rat brain.

    PubMed

    Grevel, J; Yu, V; Sadée, W

    1985-05-01

    A high-affinity binding site selective for naloxone and other 4,5-epoxymorphinans (lambda site) has been previously described in rat brain. Following homogenization of freshly dissected brain, the lambda sites convert from a high-affinity to a low-affinity state. When measured with [3H]naloxone, the decay is very rapid at 20 degrees C (t 1/2 less than 2 min), whereas it is progressively slowed at lower temperatures. Proteinase inhibitors, antoxidants, and sulfhydryl group-protecting agents failed to prevent this conversion. Kinetic measurements of mu and lambda binding at varying temperatures demonstrated that the decrease in lambda binding does not coincide with the concurrent increase in mu binding and that the loss of high-affinity lambda binding at 20 degrees C can be partially restored when the temperature is lowered to 0 degrees C. The low-affinity state of the lambda site is rather stable in the Tris buffer homogenates and is susceptible to digestion by a protease. The (-)-isomer of WIN 44,441, a benzomorphan drug, binds to lambda sites with moderate affinity (dissociation constant, KD = 63 nM), whereas the (+)-isomer does not (KD greater than 10,000 nM), thus establishing stereoselectivity of the binding process. Neither the high-affinity nor the low-affinity state of lambda binding is significantly affected by the presence of 100 mM sodium chloride or 50 microM Gpp(NH)p, (a GTP analog), which is in contrast to the dramatic effect of these agents on the established opioid receptor system. Naltrexone, naloxone, nalorphine, and morphine (in this order of decreasing potency) bind to the lambda site in vivo in intact rat brain over dosage ranges that are commonly employed in pharmacological studies.

  4. Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections

    PubMed Central

    Lee, Sanghyun; Baldridge, Megan T.

    2017-01-01

    Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-λ has therapeutic potential against enteric viral infections, many of which lack other effective treatments. In this mini-review, we describe recent advances regarding IFN-λ-mediated regulation of enteric viruses with important clinical relevance including rotavirus, reovirus, and norovirus. We also briefly discuss IFN-λ interactions with other cytokines important in the intestine, and how IFN-λ may play a role in regulation of intestinal viruses by the commensal microbiome. Finally, we indicate currently outstanding questions regarding IFN-λ control of enteric infections that remain to be explored to enhance our understanding of this important immune molecule. PMID:28713375

  5. Comparison of Cluster Lensing Profiles with Lambda CDM Predictions

    SciTech Connect

    Broadhurst, Tom; Umetsu, Keiichi; Medezinski, Elinor; Oguri, Masamune; Rephaeli, Yoel; /Tel Aviv U. /San Diego, CASS

    2008-05-21

    We derive lens distortion and magnification profiles of four well known clusters observed with Subaru. Each cluster is very well fitted by the general form predicted for Cold Dark Matter (CDM) dominated halos, with good consistency found between the independent distortion and magnification measurements. The inferred level of mass concentration is surprisingly high, 8 < c{sub vir} < 15 ( = 10.39 {+-} 0.91), compared to the relatively shallow profiles predicted by the {Lambda}CDM model, c{sub vir} = 5.06 {+-} 1.10 (for = 1.25 x 10{sup 15} M{sub {circle_dot}}/h). This represents a 4{sigma} discrepancy, and includes the relatively modest effects of projection bias and profile evolution derived from N-body simulations, which oppose each other with little residual effect. In the context of CDM based cosmologies, this discrepancy implies some modification of the widely assumed spectrum of initial density perturbations, so clusters collapse earlier (z {ge} 1) than predicted (z < 0.5) when the Universe was correspondingly denser.

  6. Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus.

    PubMed

    Lukacikova, Lubomira; Oveckova, Ingrid; Betakova, Tatiana; Laposova, Katarina; Polcicova, Katarina; Pastorekova, Silvia; Pastorek, Jaromir; Tomaskova, Jana

    2015-07-01

    Lambda interferons inhibit replication of many viruses, but their role in the inhibition of lymphocytic choriomeningitis virus (LCMV) infection remains unclear. In this study, we examined the antiviral effects of interferon (IFN)-λ2 and IFN-λ3 against LCMV in A549 cells. We found that IFN-λ2 is a more potent inhibitor of LCMV strain MX compared with IFN-λ3, whereas both cytokines have similar antiviral effects against an immunosuppressive variant of LCMV, clone-13. We also demonstrated that the antiviral activity of IFN-λ2 is more effective if it is delivered early rather than after establishment of a long-term infection, suggesting that virus replication is only partially responsive to the cytokine. In agreement with this observation, we showed that LCMV infection significantly reduces IFNLR1 mRNA expression in infected cells. In addition, LCMV infection, to some extent, compromises the signal transduction pathway of IFN-λ2. This implies that IFN receptors as well as their downstream signaling components could be selectively targeted either directly by LCMV proteins or indirectly by cellular factor(s) that are induced or activated by LCMV infection.

  7. Ghost-gluon running coupling, power corrections, and the determination of {lambda}{sub MS}

    SciTech Connect

    Boucaud, Ph.; Leroy, J. P.; Le Yaouanc, A.; Micheli, J.; Pene, O.; De Soto, F.; Rodriguez-Quintero, J.

    2009-01-01

    We compute a formula including operator-product expansion power corrections to describe the running of a QCD coupling nonperturbatively defined through the ghost and gluon dressing functions. This turns out to be rather accurate. We propose the 'plateau' procedure to compute {lambda}{sub MS} from the lattice computation of the running coupling constant. We show a good agreement between the different methods which have been used to estimate {lambda}{sub MS}{sup N{sub f}}{sup =0}. We argue that {lambda}{sub MS} or the strong coupling constant computed with different lattice spacings may be used to estimate the lattice spacing ratio.

  8. High accuracy heat capacity measurements through the lambda transition of helium with very high temperature resolution

    NASA Technical Reports Server (NTRS)

    Fairbanks, W. M.; Lipa, J. A.

    1984-01-01

    A measurement of the heat capacity singularity of helium at the lambda transition was performed with the aim of improving tests of the Renormalization Group (RG) predictions for the static thermodynamic behavior near the singularity. The goal was to approach as closely as possible to the lambda-point while making heat capacity measurements of high accuracy. To do this, a new temperature sensor capable of unprecedented resolution near the lambda-point, and two thermal control systems were used. A short description of the theoretical background and motivation is given. The initial apparatus and results are also described.

  9. Experimental Investigation Into the Aerodynamic Ground Effect of a Tailless Chevron and Lambda-shaped UCAVs

    DTIC Science & Technology

    2006-03-01

    58 Figure 39: Lambda UCAV Model and Wind Tunnel in Gridgen ..…… ………....……..60 Figure 40: Lambda UCAV Model’s...created in this study and converted it to an IGES file. The IGES file was then used in Gridgen to build a grid that was used in Fluent solver...and wind tunnel in Gridgen (28). Figure 39: Lambda UCAV model and windtunnel in Gridgen at 8 degrees AOA (28) The FLUENT solver’s resuting OGE CL

  10. High Resolution Spectroscopy of {sub {lambda}}{sup 12}B by Electroproduction

    SciTech Connect

    Iodice, M.; Cusanno, F.; Urciuoli, G. M.; Acha, A.; Ambrozewicz, P.; Coman, L.; Markowitz, P.; Moteabbed, M.; Raue, B.; Reinhold, J.; Aniol, K. A.; Margaziotis, D. J.; Baturin, P.; Jiang, X.; McCormick, K.; Bertin, P. Y.; Camsonne, A.; Ferdi, C.; Blomqvist, K. I.

    2007-08-03

    An experiment measuring electroproduction of hypernuclei has been performed in hall A at Jefferson Lab on a {sup 12}C target. In order to increase counting rates and provide unambiguous kaon identification two superconducting septum magnets and a ring imaging Cherenkov detector were added to the hall A standard equipment. An unprecedented energy resolution of less than 700 keV FWHM has been achieved. Thus, the observed {sub {lambda}}{sup 12}B spectrum shows for the first time identifiable strength in the core-excited region between the ground-state s-wave {lambda} peak and the 11 MeV p-wave {lambda} peak.

  11. The tripartite capsid gene of Salmonella phage Gifsy-2 yields a capsid assembly pathway engaging features from HK97 and {lambda}

    SciTech Connect

    Effantin, Gregory; Figueroa-Bossi, Nara; Schoehn, Guy; Bossi, Lionello; Conway, James F.

    2010-07-05

    Phage Gifsy-2, a lambdoid phage infecting Salmonella, has an unusually large composite gene coding for its major capsid protein (mcp) at the C-terminal end, a ClpP-like protease at the N-terminus, and a {approx} 200 residue central domain of unknown function but which may have a scaffolding role. This combination of functions on a single coding region is more extensive than those observed in other phages such as HK97 (scaffold-capsid fusion) and {lambda} (protease-scaffold fusion). To study the structural phenotype of the unique Gifsy-2 capsid gene, we have purified Gifsy-2 particles and visualized capsids and procapsids by cryoelectron microscopy, determining structures to resolutions up to 12 A. The capsids have lambdoid T = 7 geometry and are well modeled with the atomic structures of HK97 mcp and phage {lambda} gpD decoration protein. Thus, the unique Gifsy-2 capsid protein gene yields a capsid maturation pathway engaging features from both phages HK97 and {lambda}.

  12. Determination of the {ital b}{r_arrow}{ital c} handedness using nonleptonic {Lambda}{sub {ital c}} decays

    SciTech Connect

    Koenig, B.; Koerner, J.G.; Kraemer, M.

    1994-03-01

    We consider possibilities to determine the handedness of {ital b}{r_arrow}{ital c} current transitions using semileptonic baryonic {Lambda}{sub {ital b}}{r_arrow}{Lambda}{sub {ital c}} transitions. We propose to analyze the longitudinal polarization of the daughter baryon {Lambda}{sub {ital c}} by using momentum-spin correlation measurements in the form of forward-backward (FB) asymmetry measures involving its nonleptonic decay products. We use an explicit form factor model to determine the longitudinal polarization of {Lambda}{sub {ital c}} in the semileptonic decay {Lambda}{sub {ital b}}{r_arrow}{Lambda}{sub {ital c}}+{ital l}{sup {minus}}+{bar {nu}}{sub {ital l}}. The mean longitudinal polarization of {Lambda}{sub {ital c}} is negative (positive) for left-chiral (right-chiral) {ital b}{r_arrow}{ital c} current transitions. The frame-dependent longitudinal polarization of {Lambda}{sub {ital c}} is large ({congruent}80%) in the {Lambda}{sub {ital b}} rest frame and somewhat smaller (30%--40%) in the lab frame when the {Lambda}{sub {ital b}}`s are produced on the {ital Z}{sup 0} peak. We suggest to use nonleptonic decay modes of {Lambda}{sub {ital c}} to analyze its polarization and thereby to determine the chirality of the {ital b}{r_arrow}{ital c} transition. Since {Lambda}{sub {ital b}}`s produced on the {ital Z}{sup 0} are expected to be polarized we discuss issues of the polarization transfer in {Lambda}{sub {ital b}}{r_arrow}{Lambda}{sub {ital c}} transitions. We also investigate the {ital p}{sub {perpendicular}}- and {ital p}-cut sensitivity of our predictions for the polarization of {Lambda}{sub {ital c}}.

  13. Observation of B{sup -}{yields}p{Lambda}D{sup 0} at Belle

    SciTech Connect

    Chen, P.; Wang, M.-Z.; Chang, P.; Chao, Y.; Hou, W.-S.; Hsiung, Y. B.; Liu, Y.; Shiu, J.-G.; Adachi, I.; Haba, J.; Hara, T.; Itoh, R.; Iwasaki, Y.; Katayama, N.; Kichimi, H.; Nakao, M.; Nishida, S.; Sakai, Y.; Uehara, S.; Uno, S.

    2011-10-01

    We study B{sup -} meson decays to p{Lambda}D{sup (*)0} final states using a sample of 657x10{sup 6}BB events collected at the {Upsilon}(4S) resonance with the Belle detector at the KEKB asymmetric-energy e{sup +}e{sup -} collider. The observed branching fraction for B{sup -}{yields}p{Lambda}D{sup 0} is (1.43{sub -0.25}{sup +0.28}{+-}0.18)x10{sup -5} with a significance of 8.1 standard deviations, where the uncertainties are statistical and systematic, respectively. Most of the signal events have the p{Lambda} mass peaking near threshold. No significant signal is observed for B{sup -}{yields}p{Lambda}D{sup *0} and the corresponding upper limit on the branching fraction is 4.8x10{sup -5} at the 90% confidence level.

  14. Electromagnetic Decay of the $\\Sigma^{0}(1385)$ to $\\Lambda\\gamma$

    SciTech Connect

    Keller, Dustin; Adhikari, Krishna; Adikaram-Mudiyanselage, Dasuni; Aghasyan, Mher; Amaryan, Moscov; Baghdasaryan, Hovhannes; Ball, J P; Ball, Jacques; Battaglieri, Marco; Batourine, V; Bedlinskiy, Ivan; Bennett, Robert; Biselli, Angela; Branford, Derek; Briscoe, Wilbert; Brooks, William; Burkert, Volker; Careccia, Sharon; Carman, Daniel; Casey, Liam; Cole, Philip; Contalbrigo, Marco; Crede, Volker; D'Angelo, Annalisa; Daniel, AJI; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Deur, Alexandre; Dey, Biplap; Dickson, Richard; Djalali, Chaden; Doughty, David; Dupre, Raphael; Egiyan, Hovanes; El Alaoui, Ahmed; Elfassi, Lamiaa; Eugenio, Paul; Fedotov, Gleb; Fegan, Stuart; Forest, Tony; Gabrielyan, Marianna; Gavalian, Gagik; Gevorgyan, Nerses; Giovanetti, Kevin; Girod, Francois-Xavier; Gohn, Wesley; Golovach, Evgeny; Gothe, Ralf; Graham, Lewis; Guidal, Michel; Guegan, Baptiste; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Holtrop, Maurik; Ilieva, Yordanka; Ireland, David; Isupov, Evgeny; Jawalkar, Sucheta; Jenkins, David; Jo, Hyon-Suk; Joo, Kyungseon; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Andrey; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Konczykowski, Piotr; Kubarovsky, Valery; Kuleshov, Sergey; Kuznetsov, Viacheslav; Lu, Haiyun; MacGregor, Ian; Markov, Nikolai; McAndrew, Josephine; KcKinnon, Bryan; Meyer, Curtis; Micherdzinska, Anna; Mirazita, Marco; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrison, Brian; Moutarde, Herve; Munevar Espitia, Edwin; Nadel-Turonski, Pawel; Ni, Andrey; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Osipenko, Mikhail; Ostrovidov, Alexander; Paremuzyan, Rafayel; Park, Kijun; Park, Sungkyun; Pasyuk, Eugene; Pasyuk, Evgueni; Pereira, Sergio; Pappalardo, Luciano; Pisano, Silvia; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Procureur, Sebastien; Protopopescu, Dan; Raue, Brian; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salgado, Carlos; Schott, Diane; Schumacher, Reinhard; Seder, Erin; Seraydaryan, Heghine; Sharabian, Youri; Smith, Elton; Smith, Gregory; Sober, Daniel; Stepanyan, Stepan; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tang, Wei; Taylor, Charles; Vernarsky, Brian; Vineyard, Michael; Voutier, Eric; Weinstein, Lawrence; Watts, Daniel; Wood, Michael; Zachariou, Nicholas; Zana, Lorenzo; Zhao, Bo; Zhao, Zhiwen

    2011-04-01

    The electromagnetic decay $\\Sigma^0(1385) \\to \\Lambda \\gamma$ was studied using the CLAS detector at the Thomas Jefferson National Accelerator Facility. A real photon beam with a maximum energy of 3.8 GeV was incident on a proton target, producing an exclusive final state of $K^+\\Sigma^{*0}$. We report the decay widths ratio $\\Sigma^0(1385) \\to \\Lambda\\gamma$/ $\\Sigma^0(1385) \\to \\Lambda\\pi^0$ = $1.42 \\pm 0.12(\\text{stat})_{-0.07}^{+0.11}(\\text{sys})$%. This ratio is larger than most theoretical predictions by factors ranging from 1.5-3, but is consistent with the only other experimental measurement. From the reported ratio we calculate the partial width and electromagnetic transition magnetic moment for $\\Sigma^0(1385) \\to \\Lambda\\gamma$.

  15. Absence of lambda immunoglobulin sequences on the supernumerary chromosome of the "cat eye" syndrome.

    PubMed

    Hough, C A; White, B N; Holden, J J

    1995-09-11

    The supernumerary bisatellited chromosome causing the "cat eye" syndrome (CES) is of chromosome 22 origin and consists of an inverted duplication of the 22pter-->22q11.2 region. To determine the extent of involvement of band q11.2 on the bisatellited chromosome, copy number assessment of sequences homologous to cloned lambda immunoglobulin (lambda Ig) gene region probes was carried out on DNA from individuals with CES using densitometric analysis of Southern blots. None of the 10 lambda Ig sequences studied was found in increased copy number in DNA from any of the 10 CES individuals tested, indicating that these sequences are not present on the supernumerary chromosome. The breakpoints involved in the generation of the bisatellited supernumerary chromosome associated with CES are therefore proximal to the lambda Ig gene region.

  16. Testing the renormalisation group theory of cooperative transitions at the lambda point of helium

    NASA Technical Reports Server (NTRS)

    Lipa, J. A.; Li, Q.; Chui, T. C. P.; Marek, D.

    1988-01-01

    The status of high resolution tests of the renormalization group theory of cooperative phase transitions performed near the lambda point of helium is described. The prospects for performing improved tests in space are discussed.

  17. Evidence for B Semileptonic Decays into the Lambda_c Charm Baryon

    SciTech Connect

    Aubert, Bernard; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Lopez, L.; Palano, Antimo; Pappagallo, M.; Eigen, G.; Stugu, Bjarne; Sun, L.; Abrams, G.S.; Battaglia, M.; Brown, D.N.; Cahn, Robert N.; Jacobsen, R.G.; /LBL, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /INFN, Ferrara /Frascati /Genoa U. /INFN, Genoa /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /Consorzio Milano Ricerche /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /Napoli Seconda U. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /Padua U. /INFN, Padua /Paris U., VI-VII /Pennsylvania U. /Perugia U. /INFN, Perugia /INFN, Pisa /Princeton U. /Banca di Roma /Frascati /Rostock U. /Rutherford /DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /Turin U. /INFN, Turin /Trieste U. /INFN, Trieste /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2008-11-05

    We present the first evidence for B semileptonic decays into the charmed baryon {Lambda}{sub c}{sup +} based on 420 fb{sup -1} of data collected at the {Upsilon}(4S) resonance with the BABAR detector at the PEP-II e{sup +}e{sup -} storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We measure the relative branching fraction {Beta}({bar B} {yields} {Lambda}{sub c}{sup +} X{ell}{sup -}{bar {nu}}{sub {ell}})/{Beta}({bar B} {yields} {Lambda}{sub c}{sup +}/{bar {Lambda}}{sub c}{sup -}X) = (3.2 {+-} 0.9{sub stat.} {+-} 0.9{sub syst.})%. The significance of the signal including the systematic uncertainty is 4.9 standard deviations.

  18. Analysis of coliphage lambda mutations that affect Q gene activity: puq, byp, and nin5.

    PubMed Central

    Sternberg, N; Enquist, L

    1979-01-01

    We describe in this paper the isolation and characterization of a class of mutations, designated puq, that allow phage lambda to grow better under conditions that limit the synthesis of the phage Q gene product. These mutations were located between phage genes P and Q, a region of the lambda chromosome containing two gene N-independent mutations, nin5 and byp, that we also show to be puq mutations. Whereas the puq-3 and puq-16 mutations probably map under the nin5 deletion, the byp mutation maps between this deletion and the Q lambda-Q phi 80 crossover point. These mutations likely act by increasing the synthesis of the Q gene product. We demonstrate that the clear-plaque phenotype and reduced lysogenization frequency of byp mutants depend on increased Q gene activity. The significance of these results in understanding how transcription proceeds through the P-Q region of the lambda genome is discussed. PMID:158097

  19. lambda. production in e/sup +/e/sup -/ annihilations at 29 GeV

    SciTech Connect

    Abachi, S.; Baringer, P.; Beltrami, I.; Bylsma, B.G.; DeBonte, R.; Koltick, D.; Loeffler, F.J.; Low, E.H.; McIlwain, R.L.; Miller, D.H.

    1986-05-01

    This paper presents measurements of the inclusive production cross sections of ..lambda.. baryons in e/sup +/e/sup -/ annihilations at ..sqrt..s = 29 GeV. The data sample corresponds to an integrated luminosity of 256 pb/sup -1/ collected with the High Resolution Spectrometer at PEP. Comparisons are made to the predictions of the Lund model. The data are well described using a strange diquark suppression parameter, (us/ud)/(s/d), of 0.89 +- 0.10/sub -0.16//sup +0.56/, and the measured ..lambda../sub c/ ..-->.. ..lambda.. + X branching ratio of 23 +- 10%. No polarization is observed in the ..lambda.. decays. 17 refs., 5 figs.

  20. Slow assembly and disassembly of lambda Cro repressor dimers.

    PubMed

    Jia, Haifeng; Satumba, W John; Bidwell, Gene L; Mossing, Michael C

    2005-07-29

    Dimers of Cro are required to recognize operator DNA and repress transcription, but dimerization is weak compared to DNA binding. Fluorophore-conjugated, single-cysteine variants of Cro have been used to investigate the equilibria and kinetics of dimer assembly. Equilibrium distributions of mixed dimers, monitored by fluorescence resonance energy transfer (FRET), confirm that labeled variants have equilibrium dimer dissociation constants in the micromolar concentration range. Subunit exchange experiments yield first order rate constants for dimer dissociation that range from 0.02 s(-1) to 0.04 s(-1). Association rate constants calculated from the ratios of dissociation equilibrium and rate constants range from 0.7x10(4) M(-1) s(-1) to 3x10(4) M(-1) s(-1), depending on the site of the fluorescent label. At nanomolar concentrations of subunits, assembly can be driven by addition of DNA. The bimolecular association rate constants measured under these conditions are not dramatically enhanced, ranging from 7x10(4) M(-1) s(-1) to 9x10(4) M(-1) s(-1). The association rate is second order in protein but independent of DNA concentration between 10 nM and 200 nM. The association of subunits under native conditions is more than four orders of magnitude slower than the fast assembly phase measured previously in refolding experiments, and is unaffected by peptidyl-prolyl isomerases. Stabilization of the folded structure of the protein by residue substitution in Cro F58W or reduced temperature increases the ratio of dimers to monomers and decreases the rate of subunit exchange. These data suggest that native monomers have compact structures with substantial barriers to unfolding and that unfolded or partially folded monomers are the preferred substrates for dimer assembly. Cro binding in vivo may be under kinetic rather than thermodynamic control. The slow assembly of Cro dimers demonstrated here provides a new perspective on the lysis/lysogeny switch of bacteriophage lambda.

  1. Interferon lambda inhibits dengue virus replication in epithelial cells.

    PubMed

    Palma-Ocampo, Helen K; Flores-Alonso, Juan C; Vallejo-Ruiz, Verónica; Reyes-Leyva, Julio; Flores-Mendoza, Lilian; Herrera-Camacho, Irma; Rosas-Murrieta, Nora H; Santos-López, Gerardo

    2015-09-28

    In viral disease, infection is controlled at the cellular level by type I interferon (IFN-I), but dengue virus (DENV) has the ability to inhibit this response. Type III interferon, also known as lambda IFN (IFN-III or IFN-λ), is a complementary pathway to the antiviral response by IFN-I. This work analyzed the IFN-λ (IFN-III) mediated antiviral response against DENV serotype 2 (DENV-2) infection. Dengue fever patients were sampled to determine their IFN-λ levels by ELISA. To study the IFN-λ response during DENV infection we selected the epithelial cell line C33-A, and we demonstrated that it is permissive to DENV-2 infection. The effect of IFN-λ on virus replication was determined in these cells, in parallel to the expression of IFN-stimulated genes (ISGs), and Suppressor of Cytokine Signaling (SOCS), genes measured by RT-qPCR. We found increased (~1.8 times) serological IFN-λ in dengue fever patients compared to healthy blood donors. IFN-λ inhibited DENV-2 replication in a dose-dependent manner in vitro. The reduction of viral titer corresponded with increased ISG mRNA levels (MX1 and OAS1), with the highest inhibition occurring at ISG's peak expression. Presence of IFN-negative regulators, SOCS1 and SOCS3, during DENV-2 infection was associated with reduced IFN-λ1 expression. Evidence described here suggests that IFN-λ is a good candidate inhibitor of viral replication in dengue infection. Mechanisms for the cellular and organismal interplay between DENV and IFN- λ need to be further studied as they could provide insights into strategies to treat this disease. Furthermore, we report a novel epithelial model to study dengue infection in vitro.

  2. Analysis techniques for the {Lambda}(1405) in p+p reactions

    SciTech Connect

    Siebenson, Johannes

    2010-12-28

    We present an analysis of the {Lambda}(1405){yields}{Sigma}{sup {+-}}{pi}{sup {+-}} decay in p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the High Acceptance Di-Electron Spectrometer (HADES). The extraction of the {Lambda}(1405) signal was achieved by an effective background suppression combined with a quantitatively precise determination and identification of the remaining background sources. The different techniques, used for this analysis, are presented in this work.

  3. FY04 IRAD-funded GSFC Lambda Network (L-Net) Web Pages and Related Presentations

    NASA Technical Reports Server (NTRS)

    Gary, J. Patrick

    2005-01-01

    This presentation discusses the advances in Networking Technology combining the Global Lambda Integrated Facility (GLIF) cooperation with the National Lambda Rail (NLR) implementation. It also focuses on New NASA science needing Gigbit per second networks (Gbps) with coordinated Earth Observing Program, hurricane predictions, global aerosols, remote viewing and manipulation of large Earth Science Data Sets, integration of laser and radar topographic data with land cover data.

  4. A new formalization of a meta-game using the lambda calculus.

    PubMed

    Masumoto, Gen; Ikegami, Takashi

    2005-06-01

    This paper presents a new game system formalism. The system describes both strategies and a game master (who computes scores in a given game system) in terms of lambda-calculus. This formalism revisits the prisoner's dilemma game, to discuss how meta-strategies emerge in this classical game, even without repetition. We have also examined the evolution of meta-strategies in lambda formalism.

  5. Recent D0 Measurements of Forward-Backward Asymmetries for $p\\overline{p}\\rightarrow B^\\pm, \\Lambda_b^0,$ and $\\Lambda_s^0$ Production

    SciTech Connect

    Garbincius, Peter H.

    2015-09-22

    The Forward-Backward Asymmetries in the production of B±, Λb0 , and Λs0 particles for rapidities | y | < 2 are measured by D0 for pp-bar collisions at √s = 1.96 TeV at the Fermilab Tevatron. AFB(B±) and AFBb0) are consistent with zero, while AFBs0) exhibits a statistically significant rise with increasing | y |.

  6. Determination of $${{\\rm{\\Lambda }}}_{\\overline{{\\rm{MS}}}}$$ at five loops from holographic QCD

    DOE PAGES

    Deur, Alexandre; Brodsky, Stanley J.; de Téramond, Guy F.

    2017-08-25

    Here, the recent determination of themore » $$\\beta$$--function of the QCD running coupling $$\\alpha_{\\overline{MS}}(Q^2)$$ to five-loops, provides a verification of the convergence of a novel method for determining the fundamental QCD parameter $$\\Lambda_s$$ based on the Light-Front Holographic approach to nonperturbative QCD. The new 5-loop analysis, together with improvements in determining the holographic QCD nonperturbative scale parameter $$\\kappa$$ from hadronic spectroscopy, leads to an improved precision of the value of $$\\Lambda_s$$ in the $${\\overline{MS}}$$ scheme close to a factor of two; we find $$\\Lambda^{(3)}_{\\overline{MS}}=0.339\\pm0.019$$ GeV for $$n_{f}=3$$, in excellent agreement with the world average, $$\\Lambda_{\\overline{MS}}^{(3)}=0.332\\pm0.017$$ GeV. Lastly, we also discuss the constraints imposed on the scale dependence of the strong coupling in the nonperturbative domain by superconformal quantum mechanics and its holographic embedding in anti-de Sitter space.« less

  7. Modified van Vaals-Bergman coaxial cable coil (lambda coil) for high-field imaging.

    PubMed

    Matsuzawa, H; Nakada, T

    1996-03-01

    An easily constructed, low-capacitive coupling volume coil based on the van Vaals-Bergman coaxial cable coil for high field imaging is described. The coil (designated "lambda coil") was constructed using two 5/4 length 50 omega coaxial cables matched to a 50 omega transmission line with LC bridge balun. The standing wave on the single 5/4 lambda length coaxial cable provides two points of current maxima in oppositional direction. Therefore, the four current elements necessary for effective B1 field generation can be obtained by two 5/4 lambda length coaxial cables arranged analogous to 1/2 lambda T-antenna. Capacitive coupling between the coil elements and conductive samples (i.e. animals) is minimized by simply retaining the shield of the coaxial cable for the area of voltage maxima. The lambda coil exhibited excellent performance as a volume coil with a high quality factor and highly homogeneous rf fields. Because of its dramatically simple architecture and excellent performance, the lambda coil configuration appears to be an economical alternative to the original van Vaals-Bergman design, especially for research facilities with a high field magnet and limited bore space.

  8. Isolation and characterization of mutations in the bacteriophage lambda terminase genes.

    PubMed Central

    Davidson, A; Yau, P; Murialdo, H; Gold, M

    1991-01-01

    The terminase enzyme of bacteriophage lambda is a hetero-oligomeric protein which catalyzes the site-specific endonucleolytic cleavage of lambda DNA and its packaging into phage proheads; it is composed of the products of the lambda Nul and A genes. We have developed a simple method to select mutations in the terminase genes carried on a high-copy-number plasmid, based on the ability of wild-type terminase to kill recA strains of Escherichia coli. Sixty-three different spontaneous mutations and 13 linker insertion mutations were isolated by this method and analyzed. Extracts of cells transformed by mutant plasmids displayed variable degrees of reduction in the activity of one or both terminase subunits as assayed by in vitro lambda DNA packaging. A method of genetically mapping plasmid-borne mutations in the A gene by measuring their ability to rescue various lambda Aam phages showed that the A mutations were fairly evenly distributed across the gene. Mutant A genes were also subcloned into overproducing plasmid constructs, and it was determined that more than half of them directed the synthesis of normal amounts of full-length A protein. Three of the A gene mutants displayed dramatically reduced in vitro packaging activity only when immature (uncut) lambda DNA was used as the substrate; therefore, these mutations may lie in the endonuclease domain of terminase. Interestingly, the putative endonuclease mutations mapped in two distinct locations in the A gene separated by a least 400 bp. Images PMID:1830578

  9. Topics in Particle Astrophysics

    NASA Astrophysics Data System (ADS)

    Falk, Toby David

    1994-01-01

    This dissertation consists of a study of two topics in particle astrophysics. In Part I, we examine the generation of microwave background radiation fluctuations due to an inflationary epoch in the early universe. In Chapter 1, we study the angular dependence of the three-point correlation function of microwave background fluctuations. We use the standard techniques of field theory in curved spacetime to compute, up to an overall constant, the three-point function of the inflaton field varphi and relate this to the three-point function of microwave background temperature fluctuations. In Chapter 2, we study the dependence of the size of the fluctuations on the coupling constant lambda in the inflaton potential, and in particular we show that some claims in the literature that upper bounds on the size of the fluctuations do not put an upper bound on lambda are false. In Part II, we calculate the relic density of two supersymmetric particles with an eye to studying their viability as dark matter candidates. In Chapters 3 and 4, we compute corrections to the annihilation rate for binos (B) due to sfermion mixing (Chapter 3) and some loop effects (Chapter 4). We find that the effect of sfermion mixing may be large, both on the relic density of binos and their present annihilation cross-section, which affects their prospects for detection. The effect of the loop graphs we calculate is generically small, but can be large for bino masses near half the Z mass. In Chapter 5, we do a thorough calculation of the relic density of massive (_sp{~}>500 GeV) sneutrinos (~nu). We find that the relic density may lie in the cosmologically interesting region 0.1 _sp{~ }< Omega h^2 _sp{~}< 1.0 for sneutrino masses between 1 TeV and 4 TeV. Direct detection experiments require m _{~nu} _sp{~}< 2200 GeV and Omega_{~nu }h^2 _sp{~ }< 0.4.

  10. Lambda Data Grid: Communications Architecture in Support of Grid Computing

    DTIC Science & Technology

    2006-12-21

    the trillions of collisions at the Large Hadron Collider produce a Higgs boson , the dark matter particle or a black hole? Can we create an...YearNuclear physics 1 PB/yearSLAC (BaBar experiments) 10 PB/yearCERN LHC ( Higgs boson search) 5 PB/yearRHIC (Quark-gluon plasma experiments) ᝺ PB/yearCEBAF...projects, taken from the very large number of projects in progress. High Energy Physics (HEP) – Finding ‘ Higgs ’ particle associated with mass is one of

  11. Galaxy formation in Lambda greater than 0 Friedmann models: Consequences for the number counts versus redshift test

    NASA Technical Reports Server (NTRS)

    Martel, Hugo

    1994-01-01

    We study the effect of the cosmological constant Lambda on galaxy formation using a simple spherical top-hat overdensity model. We consider models with Omega(sub 0) = 0.2, lambda(sub 0) = 0, and Omega(sub 0) = 0.2, lambda(sub 0) = 0.8 (where Omega(sub 0) is the density parameter, and lambda(sub 0) identically equal Lambda/3 H(sub 0 exp 2) where H(sub 0) is the Hubble constant). We adjust the initial power spectrum amplitude so that both models reproduce the same large-scale structures. The galaxy formation era in the lambda(sub 0) = 0 model occurs early (z approximately 6) and is very short, whereas in the lambda(sub 0) = 0.8 model the galaxy formation era starts later (z approximately 4), and last much longer, possibly all the way to the present. Consequently, galaxies at low redshift (z less than 1) are significantly more evolved in the lambda(sub 0) = 0 model than in the lambda(sub 0) = 0.8 model. This result implies that previous attempts to determine Lambda using the number counts versus redshift test are probably unreliable.

  12. Galaxy formation in Lambda greater than 0 Friedmann models: Consequences for the number counts versus redshift test

    NASA Technical Reports Server (NTRS)

    Martel, Hugo

    1994-01-01

    We study the effect of the cosmological constant Lambda on galaxy formation using a simple spherical top-hat overdensity model. We consider models with Omega(sub 0) = 0.2, lambda(sub 0) = 0, and Omega(sub 0) = 0.2, lambda(sub 0) = 0.8 (where Omega(sub 0) is the density parameter, and lambda(sub 0) identically equal Lambda/3 H(sub 0 exp 2) where H(sub 0) is the Hubble constant). We adjust the initial power spectrum amplitude so that both models reproduce the same large-scale structures. The galaxy formation era in the lambda(sub 0) = 0 model occurs early (z approximately 6) and is very short, whereas in the lambda(sub 0) = 0.8 model the galaxy formation era starts later (z approximately 4), and last much longer, possibly all the way to the present. Consequently, galaxies at low redshift (z less than 1) are significantly more evolved in the lambda(sub 0) = 0 model than in the lambda(sub 0) = 0.8 model. This result implies that previous attempts to determine Lambda using the number counts versus redshift test are probably unreliable.

  13. Modelling of particle distribution in the melting layer

    NASA Astrophysics Data System (ADS)

    de Wolf, D. A.; Russchenberg, H. W. J.; Ligthart, L. P.

    1990-12-01

    The analysis of radiowave propagation through, and radar scattering from, the melting layer requires a model of the melting ice particles with appropriate statistics of shape, size, and orientation distributions. Previous studies have indicated that the melting layer can be modeled by a collection of wet snow spheroids in air, of which the effective permittivity and the volume fraction are the most important parameters. It is proposed that the distribution of spheroid shapes can be modeled by a flat probability density of depolarization parameter lambda (3) between a minimum and a maximum value. The location of the average lambda (3) is crucial; the width is less important.

  14. Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions

    PubMed Central

    Townsend, Catherine L.; Laffy, Julie M. J.; Wu, Yu-Chang Bryan; Silva O’Hare, Joselli; Martin, Victoria; Kipling, David; Fraternali, Franca; Dunn-Walters, Deborah K.

    2016-01-01

    Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains and probed the Protein Data Bank to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda, and heavy chain gene rearrangements are correlated within donors but can differ between donors. This indicates that terminal deoxynucleotidyl transferase may work with differing efficiencies between different people but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response. PMID:27729912

  15. Regulation of the switch from early to late bacteriophage lambda DNA replication.

    PubMed

    Baranska, S; Gabig, M; Wegrzyn, A; Konopa, G; Herman-Antosiewicz, A; Hernandez, P; Schvartzman, J B; Helinski, D R; Wegrzyn, G

    2001-03-01

    There are two modes of bacteriophage lambda DNA replication following infection of its host, Escherichia coli. Early after infection, replication occurs according to the theta (theta or circle-to-circle) mode, and is later switched to the sigma (sigma or rolling-circle) mode. It is not known how this switch, occurring at a specific time in the infection cycle, is regulated. Here it is demonstrated that in wild-type cells the replication starting from orilambda proceeds both bidirectionally and unidirectionally, whereas in bacteria devoid of a functional DnaA protein, replication from orilambda is predominantly unidirectional. The regulation of directionality of replication from orilambda is mediated by positive control of lambda p(R) promoter activity by DnaA, since the mode of replication of an artificial lambda replicon bearing the p(tet) promoter instead of p(R) was found to be independent of DnaA function. These findings and results of density-shift experiments suggest that in dnaA mutants infected with lambda, phage DNA replication proceeds predominantly according to the unidirectional theta mechanism and is switched early after infection to the sigma mode. It is proposed that in wild-type E. coli cells infected with lambda, phage DNA replication proceeds according to a bidirectional theta mechanism early after infection due to efficient transcriptional activation of orilambda, stimulated by the host DnaA protein. After a few rounds of this type of replication, the resulting increased copy number of lambda genomic DNA may cause a depletion of free DnaA protein because of its interaction with the multiple DnaA-binding sites in lambda DNA. It is proposed that this may lead to inefficient transcriptional activation of orilambda resulting in unidirectional theta replication followed by sigma type replication.

  16. RAMAN SCATTERED He II {lambda}4332 IN THE SYMBIOTIC STAR V1016 CYGNI

    SciTech Connect

    Lee, Hee-Won

    2012-05-10

    Raman scattering of He II line photons with atomic hydrogen is important in studying the mass loss processes in many symbiotic stars and a number of young planetary nebulae. We calculate the scattering cross sections and branching ratios associated with the Raman scattered He II {lambda}4332 feature formed through inelastic scattering of He II {lambda}949 with a hydrogen atom. At the line center of He II {lambda}949, the total scattering cross section is computed to be {sigma}{sub tot} = 2.5 Multiplication-Sign 10{sup -22} cm{sup 2}, and the branching ratio into the level 2s is 0.12. We also present a high-resolution spectrum of the symbiotic star V1016 Cygni obtained with the 1.8 m telescope at Mt. Bohyun to investigate the Raman scattering origin of the broad feature blueward of He II {lambda}4338. Based on the atomic calculation, we perform Monte Carlo calculations for the line formation. The scattering region is assumed to be a part of a uniform spherical shell that subtends a solid angle {Delta}{Omega} = {pi} steradian with a neutral column density N{sub HI} = 1.0 x 10{sup 21} cm{sup -2}. By adding a far-UV continuum around He II {lambda}949 normalized by the equivalent width of He II {lambda}949 to be 2.3 Angstrom-Sign , we obtain a good fit for both the Raman scattered He II {lambda}4332 and the broad wings around H{gamma}. Our analysis of the Raman feature blueward of H{gamma} in V1016 Cyg is consistent with the previous study of the Raman features blueward of H{alpha} and H{beta} by Jung and Lee.

  17. Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.

    PubMed

    Townsend, Catherine L; Laffy, Julie M J; Wu, Yu-Chang Bryan; Silva O'Hare, Joselli; Martin, Victoria; Kipling, David; Fraternali, Franca; Dunn-Walters, Deborah K

    2016-01-01

    Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains and probed the Protein Data Bank to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda, and heavy chain gene rearrangements are correlated within donors but can differ between donors. This indicates that terminal deoxynucleotidyl transferase may work with differing efficiencies between different people but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  18. Forward {Lambda} production and nuclear stopping power in d+Au collisions at {radical}{ovr s}{sub NN} =200 GeV.

    SciTech Connect

    Abelev, B. I.; Aggarwal, M. M.; Ahammed, Z.; Anderson, B. D.; Arkhipkin, D.; Krueger, K.; Spinka, H. M.; Underwood, D. G.; STAR Collaboration; High Energy Physics; Univ. of Illinois; Panjab Univ.; Variable Energy Cyclotron Centre; Kent State Univ.; Particle Physic Lab.

    2007-01-01

    We report the measurement of {Lambda} and {bar {Lambda}} and yields and inverse slope parameters in d+Au collisions at {radical}s{sub NN} = 200 GeV at forward and backward rapidities (y = {+-} 2.75), using data from the STAR forward time projection chambers. The contributions of different processes to baryon transport and particle production are probed exploiting the inherent asymmetry of the d+Au system. Comparisons to model calculations show that baryon transport on the deuteron side is consistent with multiple collisions of the deuteron nucleons with gold participants. On the gold side, HIJING-based models without a hadronic rescattering phase do not describe the measured particle yields, while models that include target remnants or hadronic rescattering do. The multichain model can provide a good description of the net baryon density in d+Au collisions at energies currently available at the BNL Relativistic Heavy Ion Collider, and the derived parameters of the model agree with those from nuclear collisions at lower energies.

  19. Design of lambda Cro fold: solution structure of a monomeric variant of the de novo protein.

    PubMed

    Isogai, Yasuhiro; Ito, Yutaka; Ikeya, Teppei; Shiro, Yoshitsugu; Ota, Motonori

    2005-12-09

    One of the classical DNA-binding proteins, bacteriophage lambda Cro, forms a homodimer with a unique fold of alpha-helices and beta-sheets. We have computationally designed an artificial sequence of 60 amino acid residues to stabilize the backbone tertiary structure of the lambda Cro dimer by simulated annealing using knowledge-based structure-sequence compatibility functions. The designed amino acid sequence has 25% identity with that of natural lambda Cro and preserves Phe58, which is important for formation of the stably folded structure of lambda Cro. The designed dimer protein and its monomeric variant, which was redesigned by the insertion of a beta-hairpin sequence at the C-terminal region to prevent dimerization, were synthesized and biochemically characterized to be well folded. The designed protein was monomeric under a wide range of protein concentrations and its solution structure was determined by NMR spectroscopy. The solved structure is similar to that of a monomeric variant of natural lambda Cro with a root-mean-square deviation of the polypeptide backbones at 2.1A and has a well-packed protein core. Thus, our knowledge-based functions provide approximate but essential relationships between amino acid sequences and protein structures, and are useful for finding novel sequences that are foldable into a given target structure.

  20. Novel interferon-{lambda}s induce antiproliferative effects in neuroendocrine tumor cells

    SciTech Connect

    Zitzmann, Kathrin; Brand, Stephan; Baehs, Sebastian; Goeke, Burkhard; Meinecke, Jennifer; Spoettl, Gerald; Meyer, Heinrich; Auernhammer, Christoph J. . E-mail: Christoph.Auernhammer@med.uni-muenchen.de

    2006-06-16

    Interferon-{alpha} (IFN-{alpha}) is used for biotherapy of neuroendocrine carcinomas. The interferon-{lambda}s (IL-28A/B and IL-29) are a novel group of interferons. In this study, we investigated the effects of the IFN-{lambda}s IL-28A and IL-29 on human neuroendocrine BON1 tumor cells. Similar to IFN-{alpha}, incubation of BON1 cells with IL-28A (10 ng/ml) and IL-29 (10 ng/ml) induced phosphorylation of STAT1, STAT2, and STAT3, significantly decreased cell numbers in a proliferation assay, and induced apoptosis as demonstrated by poly(ADP-ribose) polymerase (PARP)-cleavage, caspase-3-cleavage, and DNA-fragmentation. Stable overexpression of suppressor of cytokine signaling proteins (SOCS1 and SOCS3) completely abolished the aforementioned effects indicating that SOCS proteins act as negative regulators of IFN-{lambda} signaling in BON1 cells. In conclusion, the novel IFN-{lambda}s IL-28A and IL-29 potently induce STAT signaling and antiproliferative effects in neuroendocrine BON1 tumor cells. Thus, IFN-{lambda}s may hint a promising new approach in the antiproliferative therapy of neuroendocrine tumors.

  1. An {alpha}-cluster model for {sub {Lambda}}{sup 9}Be spectroscopy

    SciTech Connect

    Filikhin, I. N. Suslov, V. M.; Vlahovic, B.

    2013-03-15

    An {alpha}-cluster model is applied to study low-lying spectrum of the {sub {Lambda}}{sup 9}Be hypernucleus. The three-body {alpha}{alpha}{Lambda} problem is numerically solved by the Faddeev equations in configuration space using phenomenological pair potentials. We found a set of the potentials that reproduces experimental data for the ground state (1/2{sup +}) binding energy and excitation energy of the 5/2{sup +} and 3/2{sup +} states, simultaneously. This set includes the Ali-Bodmer potential of the version 'e' for {alpha}{alpha} and modified Tang-Herndon potential for {alpha}{Lambda} interactions. The spin-orbit {alpha}{Lambda} interaction is given by modified Scheerbaum potential. Low-lying energy levels are evaluated applying a variant of the analytical continuation method in the coupling constant. It is shown that the spectral properties of {sub {Lambda}}{sup 9}Be can be classified as an analog of {sup 9}Be spectrum with the exception of several 'genuine hypernuclear states'. This agrees qualitatively with previous studies. The results are compared with experimental data and new interpretation of the spectral structure is discussed.

  2. The Protein Interaction Network of Bacteriophage Lambda with Its Host, Escherichia coli

    PubMed Central

    Blasche, Sonja; Wuchty, Stefan; Rajagopala, Seesandra V.

    2013-01-01

    Although most of the 73 open reading frames (ORFs) in bacteriophage λ have been investigated intensively, the function of many genes in host-phage interactions remains poorly understood. Using yeast two-hybrid screens of all lambda ORFs for interactions with its host Escherichia coli, we determined a raw data set of 631 host-phage interactions resulting in a set of 62 high-confidence interactions after multiple rounds of retesting. These links suggest novel regulatory interactions between the E. coli transcriptional network and lambda proteins. Targeted host proteins and genes required for lambda infection are enriched among highly connected proteins, suggesting that bacteriophages resemble interaction patterns of human viruses. Lambda tail proteins interact with both bacterial fimbrial proteins and E. coli proteins homologous to other phage proteins. Lambda appears to dramatically differ from other phages, such as T7, because of its unusually large number of modified and processed proteins, which reduces the number of host-virus interactions detectable by yeast two-hybrid screens. PMID:24049175

  3. Dual resistance to lambda-cyhalothrin and dicrotophos in Hippodamia convergens (Coleoptera: Coccinellidae).

    PubMed

    Barbosa, Paulo R R; Michaud, J P; Rodrigues, Agna R S; Torres, Jorge B

    2016-09-01

    Insecticide resistance is usually associated with pests, but may also evolve in natural enemies. In this study, adult beetles of three distinct North American populations of Hippodamia convergens Guérin-Méneville, and the progeny of reciprocal crosses between the resistant and most susceptible population, were treated topically with varying concentrations of lambda-cyhalothrin and dicrotophos. In addition, the LD50s of both insecticides were applied in combination to resistant individuals. The developmental and reproductive performance of each population was assessed in the absence of insecticide exposure to compare baseline fitness. California and Kansas populations were susceptible to both materials, whereas Georgia (GA) beetles exhibited a resistance ratio (RR50) of 158 to lambda-cyhalothrin and 530 to dicrotophos. Inheritance of lambda-cyhalothrin resistance was X-linked, whereas inheritance of dicrotophos resistance was autosomal. Mortality of resistant beetles treated with a mixture of LD50s of both materials was twice that of those treated with lambda-cyhalothrin alone, but not significantly different from those receiving dicrotophos alone. Life history parameters were largely similar among populations, except that Georgia beetles had higher egg fertility relative to susceptible populations. We conclude that the high levels of resistance to lambda-cyhalothrin and dicrotophos in Georgia beetles reflect heavy loads of these insecticides in local environments, most likely the large acreage under intensive cotton cultivation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Lambda Station: Alternate network path forwarding for production SciDAC applications

    SciTech Connect

    Grigoriev, Maxim; Bobyshev, Andrey; Crawford, Matt; DeMar, Phil; Grigaliunas, Vyto; Moibenko, Alexander; Petravick, Don; Newman, Harvey; Steenberg, Conrad; Thomas, Michael; /Caltech

    2007-09-01

    The LHC era will start very soon, creating immense data volumes capable of demanding allocation of an entire network circuit for task-driven applications. Circuit-based alternate network paths are one solution to meeting the LHC high bandwidth network requirements. The Lambda Station project is aimed at addressing growing requirements for dynamic allocation of alternate network paths. Lambda Station facilitates the rerouting of designated traffic through site LAN infrastructure onto so-called 'high-impact' wide-area networks. The prototype Lambda Station developed with Service Oriented Architecture (SOA) approach in mind will be presented. Lambda Station has been successfully integrated into the production version of the Storage Resource Manager (SRM), and deployed at US CMS Tier1 center at Fermilab, as well as at US-CMS Tier-2 site at Caltech. This paper will discuss experiences using the prototype system with production SciDAC applications for data movement between Fermilab and Caltech. The architecture and design principles of the production version Lambda Station software, currently being implemented as Java based web services, will also be presented in this paper.

  5. Rifampin-stimulated uv resistance of phage lambda on Escherichia coli K12

    SciTech Connect

    Bronner, C.E.; Fluke, D.J.; Pollard, E.C.

    1983-01-01

    The plaque survival of uv-irradiated phage lambda on excision-proficient E.coli strain AB1157 is greater if the host cells are exposed to rifampin for 10 minutes prior to infection. This repair is accompanied by little or no clear-plaque mutagenesis. Host cells uv-irradiated and incubated for 30 minutes in growth medium prior to treatment with rifampin show some Weigle-reactivation in addition to the repair stimulated by rifampin. Some clear-plaque Weigle-mutagenesis is also observed in the presence of rifampin: however, the amount is less than that seen in the absence of rifampin treatment. In contrast, the uv sensitivity of lambda on strain AB1886, an excision-repair deficient mutant, is unchanged by pre-treating the cells with rifampin, and no Weigle-reactivation is observed. These results suggest that repair of lambda on unirradiated cells in the presence of rifampin is an excision-dependent, error-free phenomenon. Since initiation of replication of lambda DNA requires RNA polymerase, and since rifampin blocks transcription by that polymerase, the effect of rifampin on the survival of lambda may be to delay phage replication, thereby allowing more time for excision repair to operate. 6 figures.

  6. In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus.

    PubMed

    Zhou, Gefei; Sun, YuePing; Xin, Hua; Zhang, Yuna; Li, Zhien; Xu, Zuhong

    2004-07-01

    lambda-Carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. lambda-Carrageenan from Chondrus ocellatus, an important economic alga in China and many other parts of the world, was degraded by microwave, and obtained five products that have different molecular weight: 650, 240, 140, 15, 9.3 kDa. Analytical results confirmed that microwave degradation might not change the chemical components and structure of polysaccharides under certain condition. In this study, tumor-inhibiting activities, weight of immune organ, nature killer cells activity, lymphocyte proliferation ratio and pathological slice of spleen and tumor cells from the control group and lambda-carrageenan-treated mice of transplanted S180 and H22 tumor were investigated. The results indicated that the five lambda-carrageenan samples all showed antitumor and immunomodulation activities in different degree. Molecular weight of polysaccharides had notable effect on the activities. In addition, their antitumor and immunomodulation have some relevance and the five lambda-carrageenans probably inhibited tumor by means of activating the immunocompetence of the body. Among all the experiment results, samples with the highest activities are PC4 and PC5 whose molecular weight are 15 and 9.3 kDa.

  7. Proposal and demonstration of lambda-based internet exchange (IX) point using GMPLS protocols and photonic cross-connect (PXC)

    NASA Astrophysics Data System (ADS)

    Tsuritani, Takehiro; Okamoto, Shuichi; Ogino, Nagao; Otani, Tomohiro; Tanaka, Hideaki

    2004-10-01

    This paper proposes an architecture of a next-generation Internet eXchange (IX) based on the Generalized Multi-Protocol Label Switching (GMPLS) technologies and the photonic cross-connect (PXC), hereafter referred to a Lambda-IX. At first, we investigate a basic Lambda-IX model where the PXC provides a GMPLS-controlled lambda label-switched path (LSP) to interconnect different ISPs' border routers. We verify that the proposed Lambda-IX model can achieve the lambda-based and resilient interconnection for the ISPs, thanks to the PXC's bit-rate insensitive operation as well as fast restoration operation. In addition, once GMPLS functionalities are introduced on the border routers as well as the PXC, very flexible interconnection can be achieved such as demand-based creation and deletion of lambda LSPs. Next, we initiatively demonstrate an experimental Lambda-IX using a PXC and IP/MPLS routers. A Lambda-LSP with OC-192 bandwidth can be successfully created by using the GMPLS RSVP-TE signaling protocol via a control plane, and an EGP session of Border Gateway Protocol 4 (BGP-4) can be established over the Lambda-LSP created between the GMPLS-enabled border routers via a data plane. We also evaluate the fault recovery operation in the case where such Lambda-IXs are consisted of several PXCs and demonstrate that the Lambda-LSP as well as the corresponding BGP session can be restored with a fast recovery time of less than 1s. Through these investigation and demonstration, it is revealed that the Lambda-IX can be put to practical use aiming at inter-exchanging a large traffic in a near future, while enriching the functions of IX.

  8. Spectroscopy of electroproduced light to medium mass lambda hypernuclei

    SciTech Connect

    Baturin, Pavlo

    2010-01-01

    One of the main tasks of nuclear physics is the study of subatomic particles and their interactions. Nowadays, the fundamental theory of strong interactions is a particularly interesting subject in the field. At the current moment, such a theory is not complete yet. It describes very well the nucleon-nucleon (NN) interactions, which were intensively studied over the last several decades. In our modern, technically advanced world the research gravitates towards the higher energies, reaching deeper inside of the nuclear structure. About sixty years ago the strong interaction was associated with the interaction between nucleons responsible for holding those nucleons together within the nuclear volume. However, with discovery of mesons and strange particles, the picture has changed. The proof of bound states of strange baryons (Λ particles) with nucleons revealed a broad class of particles participating in the strong interaction, called hadrons. The rich variety of hadron interactions raises an important topic in modern nuclear physics which strives for providing a deep insight into nuclear matter structure. The analysis of the interaction of a strange baryon, called a hyperon, with a nucleon delivers new knowledge of nuclear properties, which were not understood with widely studied nucleon-nucleon interactions. The direct approach for creating an interaction of free hyperons with nucleons in the target is not an easy task in experimental nuclear physics. The relatively short lifetime of free hyperons, which can only be produced as a secondary beam, leads to extremely low statistics. Nowadays, the best known method of hyperon-nucleon interaction study is the formation of hyperons inside of the nucleus. The bound hyperon serves as a probe of nuclear properties of such complex nuclear systems called hypernuclei. Hypernuclear physics itself is a sub-area of nuclear physics, which studies such bound systems. It employs the rich knowledge of the nucleon-nucleon interaction

  9. Strange particle production in hadronic Z{sup 0} decays

    SciTech Connect

    Baird, K.G. III

    1996-04-01

    A study has been made of neutral strange baryons and pseudoscalar mesons produced in hadronic decays of the weak gauge boson V. The experiment was performed at the Stanford Linear Accelerator Center, which has the unique capability of colliding highly polarized electrons with unpolarized positrons. Overall production rates and spectra of the K{sup 0} and the {Lambda}{sup 0} (+{Lambda}{sup 0}) were measured and compared with other experiments as well as with Quantum Chromodynamics calculations. The combination of the small, stable beam spots produced by the SLAC Linear Collider (SLC) and the precision vertexing capabilities of the SLC Large Detector (SLD) permitted the separation of the hadronic events into three quark flavor-enriched samples. An unfolding was performed to obtain flavor-pure samples, and for the first time measurements were made of K{sup 0} and {Lambda}{sup 0} (+{Lambda}{sup 0}) production rates and spectra in uds, c, and b quark events at the Z{sup 0} pole. This measurement revealed significant production differences. Utilizing the large quark production asymmetry due to the polarized electron beam, high-purity quark and antiquark jet samples were obtained. The first measurement of production differences of the {Lambda}{sup 0} baryon in quark and antiquark jets was performed, which provided clear evidence for a leading particle effect at high momenta.

  10. Experiments with the High Resolution Kaon Spectrometer at Jlab Hall C and the New Spectroscopy of ^12_Lambda B Hypernuclei

    SciTech Connect

    Tang, Liguang; Chen, Chunhua; Gogami, Toshiyuki; Kawama, Daisuke; Han, Yuncheng; Yuan, Lulin; Matsumura, Akihiko; Okayasu, Yuichi; Seva, Tomislav; Rodriguez, Victor; Baturin, Pavlo; Acha Quimper, Armando; Achenbach, Carsten; Ahmidouch, Abdellah; Albayrak, Ibrahim; Androic, Darko; Asaturyan, Arshak; Asaturyan, Razmik; Ates, Ozgur; Badui, Rafael; Baker, Oliver; Benmokhtar, Fatiha; Boeglin, Werner; Bono, Jason; Bosted, Peter; Brash, Edward; Carter, Philip; Carlini, Roger; Chiba, Atsushi; Christy, Michael; Cole, Leon; Dalton, Mark; Danagoulian, Samuel; Daniel, Aji; De Leo, Raffaele; Dharmawardane, Kahanawita; Doi, Daisuke; Egiyan, Kim; Elaasar, Mostafa; Ent, Rolf; Fenker, Howard; Fujii, Yu; Furic, Miroslav; Gabrielyan, Marianna; Gan, Liping; Garibaldi, Franco; Gaskell, David; Gasparian, Ashot; Gibson, Edward; Gueye, Paul; Hashimoto, Osamu; Honda, D; Horn, Tanja; Hu, Bitao; Hungerford, Ed; Jayalath, Chandana; Jones, Mark; Johnston, Kathleen; Kalantarians, Narbe; Kanda, Hiroki; Kaneta, M; Kato, F; Kato, Seigo; Kawai, Masaharu; Keppel, Cynthia; Khanal, Hari; Kohl, M; Kramer, Laird; Lan, Kejian; Li, Ya; Habarakada Liyanage, Anusha; Luo, Wei; Mack, David; Maeda, Kazushige; Malace, Simona; Margaryan, Amur; Marikyan, Gagik; Markowitz, Pete; Maruta, Tomofumi; Maruyama, Nayuta; Maxwell, Victor; Millener, David; Miyoshi, Toshinobu; Mkrtchyan, Arthur; Mkrtchyan, Hamlet; Motoba, Toshio; Nagao, Sho; Nakamura, Satoshi; Narayan, Amrendra; Neville, Casey; Niculescu, Gabriel; Niculescu, Maria; Nunez, Angel; Nuruzzaman, nfn; Nomura, Hiroshi; Nonaka, Kenichi; Ohtani, Atsushi; Oyamada, Masamichi; Perez, Naipy; Petkovic, Tomislav; Pochodzalla, J; Qiu, Xiyu; Randeniya, Kapugodage; Raue, Brian; Reinhold, Joerg; Rivera, R; Roche, Julie; Samanta, Chhanda; Sato, Yoshinori; Sawatzky, Bradley; Segbefia, Edwin; Schott, Diane; Shichijo, Ayako; Simicevic, Neven; Smith, Gregory; Song, Yushou; Sumihama, Mizuki; Tadevosyan, Vardan; Takahashi, Toshiyuki; Taniya, Naotaka; Tsukada, Kyo; Tvaskis, Vladas; Veilleux, Micah; Vulcan, William; Wells, Steven; Wesselmann, Frank; Wood, Stephen; Yamamoto, Taku; Yan, Chen; Ye, Z; Yokota, Kosuke; Zhamkochyan, Simon; Zhu, Lingyan

    2014-09-01

    Since the pioneering experiment, E89-009 studying hypernuclear spectroscopy using the $(e,e^{\\prime}K^+)$ reaction was completed, two additional experiments, E01-011 and E05-115, were performed at Jefferson Lab. These later experiments used a modified experimental design, the "Tilt Method", to dramatically suppress the large electromagnetic background, and allowed for a substantial increase in luminosity. Additionally, a new kaon spectrometer, HKS (E01-011), a new electron spectrometer, HES, and a new splitting magnet were added to produce precision, high-resolution hypernuclear spectroscopy. These two experiments, E01-011 and E05-115, resulted in two new data sets, producing sub-MeV energy resolution in the spectra of ${}^{7}_{\\Lambda}\\text{He}$, ${}^{12}_{\\Lambda}\\text{B}$ and ${}^{28}_{\\Lambda} \\text{Al}$ and ${}^{7}_{\\Lambda}\\text{He}$, ${}^{10}_{\\Lambda}\\text{Be}$, ${}^{12}_{\\Lambda}\\text{B}$ and ${}^{52}_{\\Lambda}\\text{V}$. All three experiments obtained a ${}^{12}_{\\Lambda}\\text{B}$, spectrum, which is the most characteristic $p$-shell hypernucleus and is commonly used for calibration. Independent analyses of these different experiments demonstrate excellent consistency and provide the clearest level structure to date of this hypernucleus as produced by the $(e,e^{\\prime}K^+)$ reaction. This paper presents details of these experiments, and the extraction and analysis of the observed ${}^{12}_{\\Lambda}\\text{B}$ spectrum.

  11. Observation of the Helium 7 {Lambda} hypernucleus by the (e,e'K+) reaction

    SciTech Connect

    Nakamura, Satoshi; Okayasu, Yuichi; Seva, Tomislav; Rodriguez, Victor; Baturin, Pavlo; Yuan, Lulin; Acha Quimper, Armando; Ahmidouch, Abdellah; Androic, Darko; Asaturyan, Arshak; Asaturyan, Razmik; Baker, Oliver; Benmokhtar, Fatiha; Boeglin, Wener; Bosted, Peter; Carlini, Roger; Chen, Chunhua; Christy, Michael; Cole, Leon; Danagoulian, Samuel; Daniel, Aji; Dharmawardane, Kahanawita; Egiyan, Kim; Elaasar, Mostafa; Ent, Rolf; Fenker, Howard; Fujii, Yu; Furic, Miroslav; Gan, Liping; Gaskell, David; Gasparian, Ashot; Gibson, Edward; Toshiyuki, Gogami; Gueye, Paul; Han, Yuncheng; Hashimoto, Osamu; Hiyama, E; Honda, D; Horn, Tanja; Hu, Bitao; Hungerford, Ed; Jayalath, Chandana; Jones, Mark; Johnston, Kathleen; Kalantarians, Narbe; Kanda, Hiroki; Kaneta, M; Kato, Seigo; Kato, Shigeki; Kawama, Daisuke; Keppel, Cynthia; Kramer, Laird; Lan, Kejian; Luo, Wei; Mack, David; Maeda, Kazushige; Malace, Simona; Margaryan, Amur; Marikyan, Gagik; Markowitz, Pete; Maruta, Tomofumi; Maruyama, Nayuta; Miyoshi, Toshinuobu; Mkrtchyan, Arthur; Mkrtchyan, Hamlet; Nagao, Sho; Navasardyan, Tigran; Niculescu, Gabriel; Niculescu, Maria-Ioana; Nonaka, Kenichi; Ohtani, Atsushi; Oyamada, Masamichi; Perez, Naipy; Petkovic, Tomislav; Randeniya, Kapugodage; Raue, Brian; Reinhold, Joerg; Rivera Castillo, Roberto; Roche, Julie; Sato, Yoshinori; Segbefia, Edwin; Simicevic, Neven; Smith, Gregory; Song, Yushou; Sumihama, Mizuki; Tadevosyan, Vardan; Takahashi, Toshiyuki; Tang, Liguang; Tsukada, Kyo; Tvaskis, Vladas; Vulcan, William; Wells, Steven; Wood, Stephen; Yan, Chen; Zhamkochyan, Simon

    2013-01-01

    An experiment with a newly developed high-resolution kaon spectrometer (HKS) and a scattered electron spectrometer with a novel configuration was performed in Hall C at Jefferson Lab (JLab). The ground state of a neutron-rich hypernucleus, He 7 {Lambda}, was observed for the first time with the (e,e'K+) reaction with an energy resolution of ~0.6 MeV. This resolution is the best reported to date for hypernuclear reaction spectroscopy. The He 7 {Lambda} binding energy supplies the last missing information of the A=7, T=1 hypernuclear iso-triplet, providing a new input for the charge symmetry breaking (CSB) effect of {Lambda} N potential.

  12. The exploitation of lambda tra transducing phages in the study of bacterial conjugation.

    PubMed

    Willetts, N; McIntire, S

    1979-01-01

    A set of lambda tra transducing phages have been isolated from an abnormal lysogen in which the lambda prophage was inserted into the traB gene of Flac, and characterised both genetically and physicochemically. The phages were used in several ways to facilitate studies of bacterial conjugation: (a) they aided the identification and mapping of four new transfer genes, traU, traN, traV and traW: (b) they gave information about the location and orientation of the promoters for traM, traJ and traI: (c) a more precise physical map of the transfer region was developed from the lengths of the tra segments that they carried, and (d) the molecular weights of the traM and traJ proteins synthesised by a lambda ptraMJALEK phage were determined.

  13. Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases.

    PubMed

    Kovall, R A; Matthews, B W

    1998-07-07

    lambda-exonuclease participates in DNA recombination and repair. It binds a free end of double-stranded DNA and degrades one strand in the 5' to 3' direction. The primary sequence does not appear to be related to any other protein, but the crystal structure shows part of lambda-exonuclease to be similar to the type II restriction endonucleases PvuII and EcoRV. There is also a weaker correspondence with EcoRI, BamHI, and Cfr10I. The structure comparisons not only suggest that these enzymes all share a similar catalytic mechanism and a common structural ancestor but also provide strong evidence that the toroidal structure of lambda-exonuclease encircles its DNA substrate during hydrolysis.

  14. Quartz Microbalance Study of 400-angstrom Thick Films near the lambda Point

    NASA Technical Reports Server (NTRS)

    Chan, Moses H. W.

    2003-01-01

    In a recent measurement we observed the thinning of an adsorbed helium film induced by the confinement of critical fluctuations a few millikelvin below the lambda point. A capacitor set-up was used to measure this Casimir effect. In this poster we will present our measurement of an adsorbed helium film of 400 angstroms near the lambda point with a quartz microbalance. For films this thick, we must take into account the non-linear dynamics of the shear waves in the fluid. In spite of the added complications, we were able to confirm the thinning of the film due to the Casimir effect and the onset of the superfluid transition. In addition, we observe a sharp anomaly at the bulk lambda point, most likely related to critical dissipation of the first sound. This work is carried out in collaboration with Rafael Garcia, Stephen Jordon and John Lazzaretti. This work is funded by NASA's Office of Biological and Physical Research under grant.

  15. Quartz Microbalance Study of 400-angstrom Thick Films near the lambda Point

    NASA Technical Reports Server (NTRS)

    Chan, Moses H. W.

    2003-01-01

    In a recent measurement we observed the thinning of an adsorbed helium film induced by the confinement of critical fluctuations a few millikelvin below the lambda point. A capacitor set-up was used to measure this Casimir effect. In this poster we will present our measurement of an adsorbed helium film of 400 angstroms near the lambda point with a quartz microbalance. For films this thick, we must take into account the non-linear dynamics of the shear waves in the fluid. In spite of the added complications, we were able to confirm the thinning of the film due to the Casimir effect and the onset of the superfluid transition. In addition, we observe a sharp anomaly at the bulk lambda point, most likely related to critical dissipation of the first sound. This work is carried out in collaboration with Rafael Garcia, Stephen Jordon and John Lazzaretti. This work is funded by NASA's Office of Biological and Physical Research under grant.

  16. The experimental determination of C lambda using an absorbed dose calorimeter.

    PubMed

    Williams, P C

    1980-01-01

    The absorbed dose conversion factors, C lambda, were introduced, by Greene and Massey, as an interim measure until a primary standard for high energy photon dosimetry could be established. The theoretical basis of these factors has been discussed extensively and a more rigorous definition has emerged. Experiments have been carried out to determine the values of C lambda, for a Tufnol walled, Baldwin-Farmer ionisation chamber over a range of energies from cobalt-60 to 12 MV. The experimental results, based on measurements with a calorimeter, presented here support the more rigorous definition but it is shown that the values obtained depend, to a small extent, on the assumptions made about the detailed construction of the ionisation chamber for which C lambda is measured.

  17. {lambda}NN and {sigma}NN systems at threshold. II. The effect of D waves

    SciTech Connect

    Garcilazo, H.; Valcarce, A.; Fernandez-Carames, T.

    2007-09-15

    Using the two-body interactions obtained from a chiral constituent quark model, we study all {lambda}NN and {sigma}NN states with I=0,1,2 and J=1/2,3/2 at threshold, taking into account all three-body configurations with S and D wave components. We constrain further the limits for the {lambda}N spin-triplet scattering length a{sub 1/2,1}. Using the hypertriton binding energy, we find a narrow interval for the possible values of the {lambda}N spin-singlet scattering length a{sub 1/2,0}. We find that the {sigma}NN system has a quasibound state in the (I,J)=(1,1/2) channel very near threshold with a width of about 2.1 MeV.

  18. Correlated Leading Baryon-antibaryon Production in e+e- to ccbar to Lambda_c+ antiLambda_c- X

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G. /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-08-22

    We present a study of 649 {+-} 35 e{sup +}e{sup -} {yields} c{bar c} events produced at {radical}s {approx} 10.6 GeV containing both a {Lambda}{sub c}{sup +} baryon and a {bar {Lambda}}{sub c}{sup -} antibaryon. The number observed is roughly four times that expected if the leading charmed hadron types are uncorrelated, confirming an observation by the CLEO Collaboration. We find a 2-jet topology in these events but very few additional baryons, demonstrating that the primary c and {bar c} are predominantly contained in a correlated baryon-antibaryon system. In addition to the charmed baryons we observe on average 2.6 {+-} 0.2 charged intermediate mesons, predominantly pions, carrying 65% of the remaining energy.

  19. Regulation of copy number and stability of phage lambda derived pTC lambda 1 plasmid in the light of the dimer/multimer catastrophe hypothesis.

    PubMed

    Herman-Antosiewicz, A; Wegrzyn, G

    1999-07-15

    The dimer catastrophe hypothesis has been proposed previously to explain instability of multicopy plasmids whose partitioning is random, contrary to low copy number plasmids which are stably maintained and actively partitioned. Until now, this hypothesis has been investigated using multicopy ColE1 plasmids. However, for more detailed testing of the dimer/multimer catastrophe hypothesis, one should use a plasmid which can be maintained at either low or high copy number and still possesses the same mechanism of replication regulation. Here we used a modified lambda plasmid, pTC lambda 1. The advantage of this plasmid is that it can be maintained at different copy numbers depending on the concentration of an inducer which stimulates the initiation of plasmid replication. Results obtained with this plasmid in recombination proficient and deficient cells generally support the dimer/multimer catastrophe hypothesis, but also suggest some modification in the model.

  20. Fate of the insecticide lambda-cyhalothrin in ditch enclosures differing in vegetation density.

    PubMed

    Leistra, Minze; Zweers, Anton J; Warinton, Jacqui S; Crum, Steven J H; Hand, Laurence H; Beltman, Wim H J; Maund, Stephen J

    2004-01-01

    Use of the insecticide lambda-cyhalothrin in agriculture may result in the contamination of water bodies, for example by spray drift. Therefore, the possible exposure of aquatic organisms to this insecticide needs to be evaluated. The exposure of the organisms may be reduced by the strong sorption of the insecticide to organic materials and its susceptibility to hydrolysis at the high pH values in the natural range. In experiments done in May and August, formulated lambda-cyhalothrin was mixed with the water body of enclosures in experimental ditches containing a bottom layer and macrophytes (at different densities) or phytoplankton. Concentrations of lambda-cyhalothrin in the water body and in the sediment layer, and contents in the plant compartment, were measured by gas-liquid chromatography at various times up to 1 week after application. Various water quality parameters were also measured. Concentrations of lambda-cyhalothrin decreased rapidly in the water column: 1 day after application, 24-40% of the dose remained in the water, and by 3 days it had declined to 1.8-6.5%. At the highest plant density, lambda-cyhalothrin residue in the plant compartment reached a maximum of 50% of the dose after 1 day; at intermediate and low plant densities, this maximum was only 3-11% of the dose (after 1-2 days). The percentage of the insecticide in the ditch sediment was 12% or less of the dose and tended to be lower at higher plant densities. Alkaline hydrolysis in the water near the surface of macrophytes and phytoplankton is considered to be the main dissipation process for lambda-cyhalothrin.

  1. Excess production of phage lambda delayed early proteins under conditions supporting high Escherichia coli growth rates.

    PubMed

    Gabig, M; Obuchowski, M; Wegrzyn, A; Szalewska-Pałasz, A; Thomas, M S; Wegrzyn, G

    1998-08-01

    Bacteriophage lambda is unable to lysogenize Escherichia coli hosts harbouring the rpoA341 mutation due to a drastic reduction in transcription from CII-activated lysogenic promoters (pE, pI and paQ). In addition, the level of early transcripts involved in the lytic pathway of lambda development is also decreased in this genetic background due to impaired N-dependent antitermination. Here, it is demonstrated that despite the reduced level of early lytic pL- and pR-derived transcripts, lytic growth of bacteriophage lambda is not affected in rich media. The level of the late lytic, pR-derived transcripts also remains unaffected by the rpoA341 mutation under these conditions. However, it was found that whilst there is no significant difference in the phage burst size in rpoA+ and rpoA341 hosts growing in rich media, phage lambda is not able to produce progeny in the rpoA341 mutant growing in minimal medium, in contrast to otherwise isogenic rpoA+ bacteria. Provision of an excess of the phage replication proteins O and P in trans or overproduction of the antitermination protein N restore the ability of phage lambda to produce progeny in the rpoA341 mutant under the latter conditions. These results suggest that in rich media phage lambda produces some early proteins in excess of that needed for its effective propagation and indicate that replication proteins may be limiting factors for phage lytic growth in poor media.

  2. Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry.

    PubMed

    Barnidge, David R; Dasari, Surendra; Ramirez-Alvarado, Marina; Fontan, Adrian; Willrich, Maria A V; Tschumper, Renee C; Jelinek, Diane F; Snyder, Melissa R; Dispenzieri, Angela; Katzmann, Jerry A; Murray, David L

    2014-11-07

    We previously described a microLC-ESI-Q-TOF MS method for identifying monoclonal immunoglobulins in serum and then tracking them over time using their accurate molecular mass. Here we demonstrate how the same methodology can be used to identify and characterize polyclonal immunoglobulins in serum. We establish that two molecular mass distributions observed by microLC-ESI-Q-TOF MS are from polyclonal kappa and lambda light chains using a combination of theoretical molecular masses from gene sequence data and the analysis of commercially available purified polyclonal IgG kappa and IgG lambda from normal human serum. A linear regression comparison of kappa/lambda ratios for 74 serum samples (25 hypergammaglobulinemia, 24 hypogammaglobulinemia, 25 normal) determined by microflowLC-ESI-Q-TOF MS and immunonephelometry had a slope of 1.37 and a correlation coefficient of 0.639. In addition to providing kappa/lambda ratios, the same microLC-ESI-Q-TOF MS analysis can determine the molecular mass for oligoclonal light chains observed above the polyclonal background in patient samples. In 2 patients with immune disorders and hypergammaglobulinemia, we observed a skewed polyclonal molecular mass distribution which translated into biased kappa/lambda ratios. Mass spectrometry provides a rapid and simple way to combine the polyclonal kappa/lambda light chain abundance ratios with the identification of dominant monoclonal as well as oligoclonal light chain immunoglobulins. We anticipate that this approach to evaluating immunoglobulin light chains will lead to improved understanding of immune deficiencies, autoimmune diseases, and antibody responses.

  3. Dissipation kinetics and assessment of processing factor for chlorpyrifos and lambda-cyhalothrin in cardamom.

    PubMed

    George, Thomas; Beevi, S Naseema; Xavier, George; Kumar, N Pratheesh; George, Jayesh

    2013-06-01

    The dissipation kinetics and method for estimation of residues of chlorpyrifos and lambda-cyhalothrin in cardamom were studied and developed. The limit of detection and limit of quantitation arrived for the compounds were 0.01 and 0.025 μg g(-1), respectively. Gas chromatographic response of chlorpyrifos and lambda-cyhalothrin residues was linear in the range of 0.01-0.50 μg g(-1) and the mean recovery obtained was 97.3 % for chlorpyrifos and 98.9 % for lambda-cyhalothrin with satisfactory relative standard deviation values. The mean initial residues of chlorpyrifos applied at a concentration of 0.05 % in cardamom was 2.5 μg g(-1) and the residue was 8.1 μg g(-1) after processing, with a processing factor of 3.24, while lambda-cyhalothrin when applied at 0.0025 % resulted in initial residues of 1.63 μg g(-1) that magnified to 4.86 μg g(-1) on curing, with a processing factor of 2.98. The half-life of chlorpyrifos was in the range of 5.1-5.24 days while that of lambda-cyhalothrin was in the range of 4.40-4.55 days. The processing factor arrived at in the above experiment lead to the conclusion that the residues of chlorpyrifos got magnified to 3.24-3.68 times and that of lambda-cyhalothrin got magnified to 2.98-3.46 times of initial residues, consequent to loss of weight due to dehydration during curing.

  4. Specific Heat of Helium at Constant Volume along the Lambda Line

    SciTech Connect

    Lipa, J. A.; Nissen, J. A.; Avaloff, D.; Wang, Suwen

    2006-09-07

    We report new measurements of the constant-volume specific heat of helium along the lambda line from 0.15 to 24.4 bars. The pressure in the cell was also recorded as a function of temperature using a gauge with a superconducting readout. This data can be used to convert the results to the constant-pressure specific heat along isobars. The constant-volume data compare well with earlier results and extend the temperature range of the measurements much closer to the lambda line. A preliminary conversion to Cp(T,P) indicates good agreement with universality.

  5. Neither Two-State nor Three-State: Dimerization of Lambda Cro Repressor.

    PubMed

    Yao, John; Wang, Jin

    2015-06-04

    Lambda Cro repressor is one of the best studied dimeric transcription factors. However, there has still been an unsettled debate for decades about whether it is a two-state dimer or three-state dimer. We provide a new mechanism model that can reconcile these seemingly conflicting (mutually exclusive) experimental results. From simulations with all-atom structure-based model, we observe that the dimerization process of Lambda Cro repressor starts from one folded monomer with one unfolded monomer. Intrasubunit folding and intersubunit binding are partially coupled, in a fly casting manner.

  6. Branching ratios from B{sub s} and {Lambda}{sub b}{sup 0}

    SciTech Connect

    Matthew S. Martin

    2004-05-28

    CDF Run II relative branching ratio measurements for 65 pb{sup -1} of data in the channels B{sub s} {yields} D{sub s}{sup {-+}}{pi}{sup {-+}}, {Lambda} {sub b}{sup 0} {yields} {Lambda}{sub c}{sup {+-}}{pi}{sup {-+}} and B {yields} h{sup +}h{sup -} are presented. Further, an observation of B{sub s} {yields} K{sup {+-}} K{sup {-+}} and a measurement of A{sub CP} are presented.

  7. Structure of Lambda(1405) and threshold behavior of pi Sigma scattering

    SciTech Connect

    Yoichi Ikeda, Tesuo Hyodo, Daisuke Jido, Hiroyuki Kamano, Toru Sato, Koichi Yazaki

    2011-01-01

    The scattering length and effective range of the pi-Sigma channel are studied in order to characterize the strangeness S = -1 meson-baryon scattering and the Lambda (1405) resonance. We examine various off-shell dependence of the amplitude in dynamical chiral models to evaluate the threshold quantities with the constraint at the KN threshold. We find that the pi-Sigma threshold parameters are important to the structure of the Lambda (1405) resonance and provide further constraints on the subthreshold extrapolation of the KN interaction.

  8. Solution of the symmetric eigenproblem AX=lambda BX by delayed division

    NASA Technical Reports Server (NTRS)

    Thurston, G. A.; Bains, N. J. C.

    1986-01-01

    Delayed division is an iterative method for solving the linear eigenvalue problem AX = lambda BX for a limited number of small eigenvalues and their corresponding eigenvectors. The distinctive feature of the method is the reduction of the problem to an approximate triangular form by systematically dropping quadratic terms in the eigenvalue lambda. The report describes the pivoting strategy in the reduction and the method for preserving symmetry in submatrices at each reduction step. Along with the approximate triangular reduction, the report extends some techniques used in the method of inverse subspace iteration. Examples are included for problems of varying complexity.

  9. Formation of Primordial Stars in a Lambda-CDM Universe

    SciTech Connect

    Yoshida, Naoki; Omukai, Kazuyuki; Hernquist, Lars; Abel, Tom; /KIPAC, Menlo Park

    2006-06-09

    Primordial stars are formed from a chemically pristine gas consisting of hydrogen and helium. They are believed to have been born at some early epoch in the history of the Universe and to have enriched the interstellar medium with synthesized heavy elements before the emergence of ordinary stellar populations. We study the formation of the first generation of stars in the standard cold dark matter model. We follow the gravitational collapse and thermal evolution of primordial gas clouds within early cosmic structures using very high-resolution, cosmological hydrodynamic simulations. Our simulation achieves a dynamic range of {approx} 10{sup 10} in length scale. With accurate treatment of atomic and molecular physics, it allows us to study the chemo-thermal evolution of primordial gas clouds to densities up to {rho} {approx} 2 x 10{sup -8}g cm{sup -3} (n{sub H} {approx} 10{sup 16}cm{sup -3}) without assuming any a priori equation of state; a six orders of magnitudes improvement over previous three-dimensional calculations. We implement an extensive chemistry network for hydrogen, helium and deuterium. All the relevant atomic and molecular cooling and heating processes, including cooling by collision-induced continuum emission, are implemented. For calculating optically thick H{sub 2} cooling at high densities, we use the Sobolev method (Sobolev 1960) and evaluate the molecular line opacities for a few hundred lines. We validate the accuracy of the method by performing a spherical collapse test and comparing the results with those of accurate one-dimensional calculations that treat the line radiative transfer problem in a fully self-consistent manner. We then perform a cosmological simulation adopting the standard {Lambda}CDM model. Dense gas clumps are formed at the centers of low mass ({approx} 10{sup 5-6}M{sub {circle_dot}}) dark matter halos at redshifts z {approx} 20, and they collapse gravitationally when the cloud mass exceeds a few hundred solar masses. To

  10. The stability of free convection in a particle-fluid mixture with a free surface

    SciTech Connect

    Rhazi, M.; Mir, A.; Zrikem, Z.; Gouesbet, G.

    1996-05-01

    The onset of thermal instability for simultaneous surface tension and buoyancy driven mechanisms in a horizontal fluid layer with suspended particles is theoretically investigated by means of a small disturbance analysis. The critical Marangoni, Rayleigh and wave numbers are computed and compared with those known for a pure fluid. The effect of the particles enters through three parameters: {gamma}, {phi} and {Lambda}. The first describes how much particles are present, the second is determined by the particle-fluid thermal energy change ratio (named the heat loading ratio) and the third characterizes the size of the individual particles (the particle aspect ratio). It is found that when {gamma} or {phi} increases the system is destabilized while the raise of {Lambda} destabilizes or stabilizes the layer depending on whether the Rayleigh number is positive or negative.

  11. Lambda-nuclear interactions and hyperon puzzle in neutron stars

    NASA Astrophysics Data System (ADS)

    Haidenbauer, J.; Meißner, U.-G.; Kaiser, N.; Weise, W.

    2017-06-01

    Brueckner theory is used to investigate the in-medium properties of a Λ-hyperon in nuclear and neutron matter, based on hyperon-nucleon interactions derived within SU(3) chiral effective field theory (EFT). It is shown that the resulting Λ single-particle potential U_{Λ}(p_{Λ} = 0,ρ) becomes strongly repulsive for densities ρ of two-to-three times that of normal nuclear matter. Adding a density-dependent effective Λ N-interaction constructed from chiral Λ NN three-body forces increases the repulsion further. Consequences of these findings for neutron stars are discussed. It is argued that for hyperon-nuclear interactions with properties such as those deduced from the SU(3) EFT potentials, the onset for hyperon formation in the core of neutron stars could be shifted to much higher density which, in turn, could pave the way for resolving the so-called hyperon puzzle.

  12. Inclusive Production of Strange Particles at the CERN Proton-Antiproton Collider

    NASA Astrophysics Data System (ADS)

    Tan, Ching-Hua

    1994-01-01

    During the 1987 run of the CERN Proton-Antiproton Collider, at sqrt{s} = 630 GeV, the UA1 experiment collected about 2.4 times 10^6 (65 murm b^{-1}) events with a minimum bias trigger. An extensive study of the strange particle productions in this data set was performed. The measured masses of the strange particles are in very good agreement with the particle data group values and demonstrate the superb quality of the data. The production cross sections of K_sp{S}{0}, K^+/- , Lambda and |{Lambda} are measured. K_sp{S}{0 }, K^+/- production cross section measurements are in agreement with an available new NLO QCD prediction. The K_sp{S }{0} to the charged hadrons production ratio and that of Lambda + |{Lambda} to the charged hadrons as a function of multiplicity are measured. They are well explained by the quark model. We have also compared these features with those in heavy ion experiments. The strangeness suppression factor lambda is measured to be exactly the world average value. The average p_{t} of K _sp{S}{0}, K/ pi ratio and lambda are found to increase with sqrt{s}. The predictions for K/pi and lambda are made at the LHC energy 15 TeV pp collisions. The initial energy density that UA1 reached is given and the expectations at the LHC 6300 GeV/A Pb-Pb and RHIC Au-Au 200 GeV/A collisions are illustrated. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  13. Further observations of the lambda 10830 He line in stars and their significance as a measure of stellar activity

    NASA Technical Reports Server (NTRS)

    Zirin, H.

    1975-01-01

    Measurements of the lambda 1030 He line in 198 stars are given along with data on other features in that spectral range. Nearly 80% of all G and K stars show some lambda 10830; of these, half are variable and 1/4 show emission. It was confirmed that lambda 10830 is not found in M stars, is weak in F stars, and is particularly strong in close binaries. The line is found in emission in extremely late M and S stars, along with P gamma, but P gamma is not in emission in G and K stars with lambda 10830 emissions. Variable He emission and Ti I emission are found in the RV Tauri variables R Scuti and U Mon. In R Aqr the Fe XIII coronal line lambda 10747 and a line at lambda 11012 which may be singlet He or La II are found, as well as lambda 10830 and P gamma. The nature of coronas or hot chromospheres in the various stars is discussed. It was concluded that the lambda 10830 intensity must be more or less proportional to the energy deposited in the chromosphere corona by non-thermal processes.

  14. Predictive role of the lambda ratio in the evaluation of metal-on-metal total hip replacement.

    PubMed

    Affatato, S; Spinelli, M; Zavalloni, M; Leardini, W; Viceconti, M

    2008-07-01

    The wear of metal-on-metal bearings is affected by various design parameters, such as the clearance or surface roughness. It would be very useful to have a significant indicator of wear according to these design parameters, such as the lambda ratio. Three different batches of cast high- and low-carbon cobalt-chromium hip implants (28 mm, 32 mm, and 36 mm diameters) were tested in a hip joint simulator for 2 x 10(6) cycles. Bovine calf serum was used as lubricant, and the samples were weighed at regular intervals during the test. The predictive role of the lambda ratio on the wear behaviour was investigated. Three different configurations were tested to explore the wear rate for a broad range of lambda ratios. The results of these studies clearly showed that the femoral heads of 36 mm diameter had the best wear behaviour with respect to the other two smaller configurations tested. From a predictive point of view, the lambda ratios associated with the configurations tested could clearly indicate that the femoral heads of 36 mm diameter worked in the mixed-lubrication regime (lambda > 1); all the smallest configurations (28mm size) had lambda < 1, thus showing their aptitude to work in the boundary lubrication regime, with substantially higher volume depletion due to wear. The lambda values associated with the 32 mm size varied in a range around 1 (0.95 < lambda < 1.16), suggesting the possibility of operating in the mixed-lubrication regime.

  15. Experimental Investigation of the Aerodynamic Ground Effect of a Tailless Lambda-Shaped UCAV with Wing Flaps

    DTIC Science & Technology

    2006-06-01

    Michael Wohlfahrt. Tailless Aircraft in Theory and Practice. Washington, DC: American Institute of Aeronautics and Astronautics, Inc., 1994...EXPERIMENTAL INVESTIGATION OF THE AERODYNAMIC GROUND EFFECT OF A TAILLESS LAMBDA-SHAPED UCAV WITH...or the U.S. Government. AFIT/GAE/ENY/06-J11 EXPERIMENTAL INVESTIGATION OF THE AERODYNAMIC GROUND EFFECT OF A TAILLESS LAMBDA-SHAPED UCAV

  16. Binding of hypernuclei, and phtoproduction of $\\Lambda$-hypernuclei in the latest quark-meson coupling model

    SciTech Connect

    K. Tsushima, P. A. M. Guichon, R. Shyam, A. W. Thomas

    2010-12-01

    We study the binding of hypernuclei based on the latest version of quark-meson coupling model, and estimate the phtoproduction cross sections for the {sup 12}C({gamma},K{sup +}){sub {Lambda}}{sup 12}B reaction using the bound {Lambda} spinors obtained in the model.

  17. Elevated carboxylesterase activity contributes to the lambda-cyhalothrin insensitivity in quercetin fed Helicoverpa armigera (Hübner).

    PubMed

    Chen, Chengyu; Liu, Ying; Shi, Xueyan; Desneux, Nicolas; Han, Peng; Gao, Xiwu

    2017-01-01

    Quercetin as one of the key plant secondary metabolite flavonol is ubiquitous in terrestrial plants. In this study, the decrease in sensitivity to lambda-cyhalothrin was observed in quercetin-fed Helicoverpa armigera larvae. In order to figure out the mechanisms underlying the decreased sensitivity of H. armigera larvae to lambda-cyhalothrin by quercetin induction, the changes in carboxylesterase activity and in-vitro hydrolytic metabolic capacity to lambda-cyhalothrin were examined. The LC50 value of quercetin-fed H. armigera larvae to lambda-cyhalothrin showed 2.41-fold higher than that of the control. S, S, S-Tributyl phosphorotrithioate (DEF) treatment showed a synergism effect on lambda-cyhalothrin toxicity to quercetin-fed H. armigera. Moreover, the activity of carboxylesterase was significantly higher in quercetin-fed H. armigera larvae after fed on quercetin for 48 h. The in-vitro hydrolytic metabolic capacity to lambda-cyhalothrin in quercetin-fed H. armigera larvae midgut was 289.82 nmol 3-PBA/mg protein/min, which is significant higher than that in the control group (149.60 nmol 3-PBA/mg protein/min). The elevated CarE enzyme activity and corresponding increased hydrolytic metabolic capacity to lambda-cyhalothrin in quercetin-fed H. armigera contributed to the enhanced tolerance to lambda-cyhalothrin.

  18. Mechanism of light-particle emission

    SciTech Connect

    Nagamiya, S.

    1982-02-01

    A general overview of the field of high-energy nuclear collisions studied from light particle spectra, pions, kaons, lambdas, protons, deuterons, and light composite fragments is given. Specifically, the basic reaction mechanism that determines the main features of particle emission such as the energy and angular distributions, the multiplicity, the production rate, the projectile and target mass dependences, the beam-energy dependences, etc. are discussed. Very general features of high-energy nuclear collisions are described. The major question is what characterizes these collisions. Proton emission is discussed since the proton is the dominant particle emitted at a large angle. The mechanism of composite-fragment formation is discussed. Also pion production and strange particle production are considered.

  19. A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection.

    PubMed

    Muir, Andrew J; Arora, Sanjeev; Everson, Gregory; Flisiak, Robert; George, Jacob; Ghalib, Reem; Gordon, Stuart C; Gray, Todd; Greenbloom, Susan; Hassanein, Tarek; Hillson, Jan; Horga, Maria Arantxa; Jacobson, Ira M; Jeffers, Lennox; Kowdley, Kris V; Lawitz, Eric; Lueth, Stefan; Rodriguez-Torres, Maribel; Rustgi, Vinod; Shemanski, Lynn; Shiffman, Mitchell L; Srinivasan, Subasree; Vargas, Hugo E; Vierling, John M; Xu, Dong; Lopez-Talavera, Juan C; Zeuzem, Stefan

    2014-12-01

    Peginterferon lambda-1a (Lambda) is a type-III interferon with similar antiviral activity to alfa interferons but with a diminished extrahepatic receptor distribution, reducing the risk for extrahepatic adverse events. This was a randomized, blinded, actively-controlled, multicentre phase 2b dose-ranging study in patients chronically infected with HCV genotypes 1-4. Treatment-naive patients received Lambda (120/180/240 μg) or peginterferon alfa-2a (alfa; 180 μg) once-weekly with ribavirin for 24 (genotypes [GT] 2,3) or 48 (GT1,4) weeks. Rates of undetectable HCV-RNA at week 12 (complete early virologic response [cEVR]; primary end point) were significantly higher in GT1,4 patients receiving Lambda vs. alfa (170/304, 56% vs. 38/103, 37%); with similar cEVR rates for GT2,3 (80/88, 91% vs. 26/30, 87%). Rates of undetectable HCV-RNA at week 4 were significantly higher on 180 μg (15/102, 15% GT1,4; 22/29, 76% GT2,3) and 240 μg (17/104, 16% GT1,4; 20/30, 67% GT2,3) Lambda than alfa (6/103, 6% GT1,4; 9/30, 30% GT2,3). Sustained virologic responses (post-treatment week 24) were comparable between Lambda and alfa for GT1,4 (37-46% Lambda; 37% alfa) and GT2,3 (60-76% Lambda; 53% alfa). Aminotransferase and/or bilirubin elevations were the primary dose-limiting abnormalities for Lambda; a sponsor-mandated 240 to 180 μg dose reduction was therefore implemented. Serious adverse events were comparable (3-13% Lambda; 3-7% alfa). Grade 3-4 haemoglobin, neutrophil, and platelet reductions were lower on Lambda than alfa. Among alfa patients, 28/133 (21%) had peginterferon and 31/133 (23%) had ribavirin dose reductions for haematologic abnormalities vs. 0/392 and 8/392 (2%) on Lambda. Lambda demonstrated fewer musculoskeletal (16-28% vs. 47-63%) and influenza-like events (8-23% vs. 40-46%) than alfa. Lambda was associated with improved or similar rates of virologic response with fewer extrahepatic adverse events than alfa in chronic HCV infection. Copyright © 2014 European

  20. The HKS experiment on Lambda--hypernuclear spectroscopy via electroproduction at JLab

    SciTech Connect

    Tang, Liguang; Yuan, Lulin; Acha Quimper, Armando; Ahmidouch, Abdellah; Androic, Darko; Asaturyan, Arshak; Asaturyan, Razmik; Baker, O.; Baturin, Pavlo; Benmokhtar, Fatiha; Bosted, Peter; Carlini, Roger; Chen, X.; Christy, Michael; Cole, Leon; Danagoulian, Samuel; Daniel, AJI; Dharmawardane, Kahanawita; Egiyan, Kim; Elaasar, Mostafa; Ent, Rolf; Fenker, Howard; Fujii, Yu; Furic, Miroslav; Gan, Liping; Gaskell, David; Gasparian, Ashot; Gibson, Edward; Gueye, Paul; Halkyard, Rebekah; Hashimoto, Osamu; Hashimoto, Osamu; Honda, D.; Horn, Tanja; Hu, Bitao; Hu, S.; Hungerford, Ed; Ispiryan, Mikayel; Johnston, Kathleen; Jones, Mark; Kalantarians, Narbe; Kaneta, M.; Kato, F.; Kato, Seigo; Kawama, Daisuke; Keppel, Cynthia; Li, Y.; Luo, Wei; Mack, David; Margaryan, Amur; Marikyan, Gagik; Maruyama, Nayuta; Matsumura, Akihiko; Miyoshi, Toshinobu; Mkrtchyan, Arthur; Mkrtchyan, Hamlet; Nakamura, Satoshi; Navasardyan, Tigran; Niculescu, Gabriel; Niculescu, Maria-Ioana; Nomura, Hiroshi; Nonaka, Kenichi; Ohtani, Atsushi; Okayasu, Yuichi; Pamela, Priscilla; Perez, Naipy; Petkovic, Tomislav; Randeniya, Kapugodage; Reinhold, Joerg; Rivera Castillo, Roberto; Roche, Julie; Rodriguez, Victor; Sato, Yoshinori; Seva, Tomislav; Simicevic, Neven; Smith, Gregory; Sumihama, Mizuki; Song, Yujun; Tadevosyan, Vardan; Takahashi, Toshiyuki; Tamura, Hirokazu; Tvaskis, Vladas; Vulcan, William; Wang, B.; Wells, Stephen; Wood, Stephen; Yan, Chen; Zamkochian, S.

    2008-06-01

    The HKS (Jlab E01-011) experiment on spectroscopy of Lambda-hypernuclei using (e,e'K+) reaction was successfully carried out in 2005. This paper gives a brief description of the experiment and its technique and shows some of the preliminary spectra that are still under analysis.

  1. Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions.

    PubMed

    Chugha, Preeti; Oas, Terrence G

    2007-02-06

    Oxidizing two native methionine residues predominantly populates the denatured state of monomeric lambda repressor (MetO-lambdaLS) under nondenaturing conditions. NMR was used to characterize the secondary structure and dynamics of MetO-lambdaLS in standard phosphate buffer. 13Calpha and 1Halpha chemical shift indices reveal a region of significant helicity between residues 9 and 29. This helical content is further supported by the observation of medium-range amide NOEs. The remaining residues do not exhibit significant helicity as determined by NMR. We determined 15N relaxation parameters for 64 of 85 residues at 600 and 800 MHz. There are two distinct regions of reduced flexibility, residues 8-32 in the N-terminal third and residues 50-83 in the C-terminal third. The middle third, residues 33-50, has greater flexibility. We have analyzed the amplitude of the backbone motions in terms of the physical properties of the amino acids and conclude that conformational restriction of the backbone MetO-lambdaLS is due to nascent helix formation in the region corresponding to native helix 1. The bulkiness of amino acid residues in the C-terminal third leads to the potential for hydrophobic interactions, which is suggested by chemical exchange detected by the difference in spectral density J(0) at the two static magnetic fields. The more flexible middle region is the result of a predominance of small side chains in this region.

  2. Structural and dynamical aspects of avoided-crossing resonances in a three-level {Lambda} system

    SciTech Connect

    Lizuain, I.; Echanobe, J.; Ruschhaupt, A.; Muga, J. G.; Steck, D. A.

    2010-12-15

    In a recent publication [Phys. Rev. A 79, 065602 (2009)], it was shown that an avoided-crossing resonance can be defined according to level-structural or dynamical criteria. We propose an experiment to observe the difference between the two definitions in a three-level {Lambda} system using microwave fields coupling hyperfine magnetic sublevels in alkali-metal atoms.

  3. Bone marrow lambda-type light chain crystalline structures associated with multiple myeloma.

    PubMed

    Schvartz, H; Bonhomme, P; Caulet, S; Beorchia, A; Patey, M; Caulet, T

    1985-01-01

    A 58-year-old man showed bone marrow crystalline structures associated with a lambda light chain producing multiple myeloma. Analysis and processing of electron images clearly displayed the periodic structure of the crystals. Immunochemistry suggested that they contained the whole or a fragmented constant portion of immunoglobulin.

  4. Lambda Station: On-demand flow based routing for data intensive Grid applications over multitopology networks

    SciTech Connect

    Bobyshev, A.; Crawford, M.; DeMar, P.; Grigaliunas, V.; Grigoriev, M.; Moibenko, A.; Petravick, D.; Rechenmacher, R.; Newman, H.; Bunn, J.; Van Lingen, F.; Nae, D.; Ravot, S.; Steenberg, C.; Su, X.; Thomas, M.; Xia, Y.; /Caltech

    2006-08-01

    Lambda Station is an ongoing project of Fermi National Accelerator Laboratory and the California Institute of Technology. The goal of this project is to design, develop and deploy network services for path selection, admission control and flow based forwarding of traffic among data-intensive Grid applications such as are used in High Energy Physics and other communities. Lambda Station deals with the last-mile problem in local area networks, connecting production clusters through a rich array of wide area networks. Selective forwarding of traffic is controlled dynamically at the demand of applications. This paper introduces the motivation of this project, design principles and current status. Integration of Lambda Station client API with the essential Grid middleware such as the dCache/SRM Storage Resource Manager is also described. Finally, the results of applying Lambda Station services to development and production clusters at Fermilab and Caltech over advanced networks such as DOE's UltraScience Net and NSF's UltraLight is covered.

  5. Hydroponic Uptake of Atrazine and Lambda-cyhalothrin in Aquatic Macrophytes

    NASA Astrophysics Data System (ADS)

    Bouldin, J. L.; Farris, J. L.; Moore, M. T.; Smith, S.; Cooper, C. M.

    2005-05-01

    Phytoremediation encompasses an array of plant-associated processes known to mitigate contaminants from soil, sediment, and water. Modification of pesticides associated with agricultural runoff includes processes directly associated with aquatic macrophytes in addition to soil geochemical modifications and associated rhizospheric degradation. Remediation attributes of two vegetative species common to agricultural drainages in the Mississippi Delta, USA, were assessed using atrazine and lambda-cyhalothrin. Concentrations used in 8-d hydroponic exposures were calculated using recommended field applications and a 5% runoff model from a 0.65-cm rainfall event on a 2.02-ha field. While greater atrazine uptake was measured in Juncus effusus, greater lambda-cyhalothrin uptake occurred in Ludwigia peploides. Maximum pesticide uptake was reached within 48 h for each exposure and subsequent translocation of pesticides to upper plant biomass occurred in macrophytes exposed to atrazine. Sequestration of 98.2% of lambda-cyhalothrin in roots of L. peploides was measured after 8 d. Translocation of lambda-cyhalothrin in J. effusus resulted in 25.4% of pesticide uptake partitioned to upper plant biomass. These individual macrophyte remediation studies measured species- and pesticide-specific uptake rates, indicating that the seasonality of pesticide applications and macrophyte emergence might interact strongly to enhance mitigation capabilities in edge-of-field conveyance structures.

  6. Embryonic stem cell gene targeting using bacteriophage lambda vectors generated by phage-plasmid recombination.

    PubMed Central

    Tsuzuki, T; Rancourt, D E

    1998-01-01

    Targeted mutagenesis is an extremely useful experimental approach in molecular medicine, allowing the generation of specialized animals that are mutant for any gene of interest. Currently the rate determining step in any gene targeting experiment is construction of the targeting vector (TV). In order to streamline gene targeting methods and avoid problems encountered with plasmid TVs, we describe the direct application of lambda phage in targeted mutagenesis. The recombination-proficient phage vector lambda2TK permits generation of TVs by conventional restriction-ligation or recombination-mediated methods. The resulting lambdaTV DNA can then be cleaved with restriction endonucleases to release the bacteriophage arms and can subsequently be electroporated directly into ES cells to yield gene targets. We demonstrate that in vivo phage-plasmid recombination can be used to introduce neo and lacZ - neo mutations into precise positions within a lambda2TK subclone via double crossover recombination. We describe two methods for eliminating single crossover recombinants, spi selection and size restriction, both of which result in phage TVs bearing double crossover insertions. Thus TVs can be easily and quickly generated in bacteriophage without plasmid subcloning and with little genomic sequence or restriction site information. PMID:9461458

  7. Hypertriton and light nuclei production at Lambda-production subthreshold energy in heavy-ion collisions

    SciTech Connect

    Zhang, S.; Zu, Z.; Chen, J.H., Ma, Y.G., Cai, X-Z, Ma, G.L., Zhong, C.

    2011-08-01

    High-energy heavy-ion collisions produce abundant hyperons and nucleons. A dynamical coalescence model coupled with the ART model is employed to study the production probabilities of light clusters, deuteron (d), triton (t), helion ({sup 3}He), and hypertriton ({sub {Lambda}}{sup 3}H) at subthreshold energy of Aproduction ({approx} 1 GeV per nucleon). We study the dependence on the reaction system size of the coalescence penalty factor per additional nucleon and entropy per nucleon. The Strangeness Population Factor (S{sub 3} = {sup 3}{sub {Lambda}}H/({sup 3}He x {Lambda}/p)) shows an extra suppression of hypertriton comparing to light clusters of the same mass number. This model predicts a hypertriton production cross-section of a few {mu}b in {sup 36}Ar+{sup 36}Ar, {sup 40}Ca+{sup 40}Ca and {sup 56}Ni+{sup 56}Ni in 1 A GeV reactions. The production rate is as high as a few hypertritons per million collisions, which shows that the fixed-target heavy-ion collisions at CSR (Lanzhou/China) at {Lambda} subthreshold energy are suitable for breaking new ground in hypernuclear physics.

  8. Effects of lambda-cyhalothrin on mosquito larvae and predatory aquatic insects.

    PubMed

    Lawler, Sharon P; Dritz, Deborah A; Christiansen, Julie A; Cornel, Anthony J

    2007-03-01

    Agricultural insecticides can affect mosquito production in rice fields by controlling mosquitoes, disrupting biological control or contributing to selection of insecticide resistance. The duration of insecticidal activity of the pyrethroid lambda-cyhalothrin was quantified on predatory insects in rice fields and on three kinds of mosquito larva: a pyrethroid-susceptible strain of Culex tarsalis Coquillet, a pyrethroid-resistant strain of Cx pipiens L. (sensu lato) and non-resistant Cx pipiens s.l. Lambda-cyhalothrin killed most caged, susceptible mosquitoes for up to 21 days. It killed fewer resistant Cx pipiens s.l., but suppressed their survival for over a week. Lambda-cyhalothrin suppressed field populations of predatory insects through day 29. Agricultural use of lambda-cyhalothrin can provide incidental mosquito control. However, the pyrethroid persisted in sediment and gradually decreased in activity, which could contribute to selection of pyrethroid-resistant mosquitoes. Because caged mosquitoes showed good survival before predators recovered, disruption of biological control is possible. It is therefore advisable for growers and mosquito control agencies to communicate about pesticide use.

  9. Inactivation of recombinant bacteriophage lambda by use of chemical agents and UV radiation.

    PubMed

    Clark, Ewan M; Wright, Harry; Lennon, Kelly-Anne; Craik, Vicki A; Clark, Jason R; March, John B

    2012-04-01

    Several approaches for the inactivation of bacteriophage lambda, including UV germicidal irradiation (UVGI) and the chemical agents Virkon-S, Chloros, Decon-90, and sodium hydroxide (NaOH), were compared. Virkon, NaOH, and UVGI caused a ≥7-log(10) reduction in phage titers. This study successfully describes several methods with potential for bacteriophage inactivation in industrial settings.

  10. Inactivation of Recombinant Bacteriophage Lambda by Use of Chemical Agents and UV Radiation

    PubMed Central

    Clark, Ewan M.; Wright, Harry; Lennon, Kelly-Anne; Craik, Vicki A.; Clark, Jason R.

    2012-01-01

    Several approaches for the inactivation of bacteriophage lambda, including UV germicidal irradiation (UVGI) and the chemical agents Virkon-S, Chloros, Decon-90, and sodium hydroxide (NaOH), were compared. Virkon, NaOH, and UVGI caused a ≥7-log10 reduction in phage titers. This study successfully describes several methods with potential for bacteriophage inactivation in industrial settings. PMID:22327583

  11. Locomotor activity and tissues levels following acute administration of lambda- and gamma-cyhalothrin in rats

    EPA Pesticide Factsheets

    raw motor activity counts and tissue levelsThis dataset is associated with the following publication:Moser, G., Z. Liu, C. Schlosser, T. Spanogle, A. Chandrasekaran, and K. Mcdaniel. Locomotor activity and tissue levels following acute administration of lambda- and gamma-cyhalothrin in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 313: 97-103, (2016).

  12. Low-lying {Lambda} baryons with spin 1/2 in two-flavor lattice QCD

    SciTech Connect

    Takahashi, Toru T.; Oka, Makoto

    2010-02-01

    Low-lying {Lambda} baryons with spin 1/2 are analyzed in full (unquenched) lattice QCD. We construct 2x2 cross correlators from flavor SU(3) octet and singlet baryon operators, and diagonalize them so as to extract information of two low-lying states for each parity. The two-flavor CP-PACS gauge configurations are used, which are generated in the renormalization-group improved gauge action and the O(a)-improved quark action. Three different {beta}'s, {beta}=1.80, 1.95, and 2.10, are employed, whose corresponding lattice spacings are a=0.2150, 0.1555, and 0.1076 fm. For each cutoff, we use four hopping parameters, ({kappa}{sub val},{kappa}{sub sea}), which correspond to the pion masses ranging about from 500 MeV to 1.1 GeV. Results indicate that there are two negative-parity {Lambda} states nearly degenerate at around 1.6 GeV, while no state as low as {Lambda}(1405) is observed. By decomposing the flavor components of each state, we find that the lowest (1st-excited) negative-parity state is dominated by flavor-singlet (flavor-octet) component. We also discuss meson-baryon components of each state, which has drawn considerable attention in the context of multiquark pictures of {Lambda}(1405).

  13. Radiative Corrections to Asymmetry Parameter in the {Omega}{sup -{yields}{Lambda}}+K{sup -} Decay

    SciTech Connect

    Queijeiro, A.

    2010-07-29

    We compute the radiative corrections, to first order in the fine structure constant {alpha}, to the asymmetry parameter {alpha}{sub {Omega}}of the {Omega}{sup -{yields}{Lambda}}+K{sup -} decay. We use previous results where Sirlin's procedure is used to separate the radiative corrections into two parts, one independent model contribution and a model dependent one.

  14. Measurement of sigma(Lambda(b)0) / sigma(anti-B 0) x B(Lambda0(b) ---> Lambda+(c) pi-) / B(anti-B0 ---> D+ pi-) in p anti-p collisions at S**(1/2) = 1.96-TeV

    SciTech Connect

    Abulencia, A.; Acosta, D.; Adelman, Jahred A.; Affolder, Anthony A.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; /Taiwan, Inst. Phys. /Argonne /Barcelona, IFAE /Baylor U. /INFN, Bologna /Bologna U. /Brandeis U. /UC, Davis /UCLA /UC, San Diego /UC, Santa Barbara

    2006-01-01

    The authors present the first observation of the baryon decay {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +} {pi}{sup -} followed by {Lambda}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +} in 106 pb{sup -1} p{bar p} collisions at {radical}s = 1.96 TeV in the CDF experiment. IN order to reduce systematic error, the measured rate for {Lambda}{sub b}{sup 0} decay is normalized to the kinematically similar meson decay {bar B}{sup 0} {yields} D{sup +}{pi}{sup -} followed by D{sup +} {yields} {pi}{sup +}K{sup -}{pi}{sup +}. They report the ratio of production cross sections ({sigma}) times the ratio of branching fractions ({Beta}) for the momentum region integrated above p{sub T} > 6 GeV/c and pseudorapidity range |{eta}| < 1.3: {sigma}(p{bar p} {yields} {Lambda}{sub b}{sup 0}X)/{sigma}(p{bar p} {yields} {bar B}{sup 0} X) x {Beta}({Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -})/{Beta}({bar B}{sup 0} {yields} D{sup +}{pi}{sup -}) = 0.82 {+-} 0.08(stat) {+-} 0.11(syst) {+-} 0.22 ({Beta}({Lambda}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +})).

  15. Functional humanization of an anti-CD16 Fab fragment: obstacles of switching from murine {lambda} to human {lambda} or {kappa} light chains.

    PubMed

    Schlapschy, Martin; Fogarasi, Marton; Gruber, Helga; Gresch, Oliver; Schäfer, Claudia; Aguib, Yasmine; Skerra, Arne

    2009-03-01

    An alphaCD30xalphaCD16 bispecific monoclonal antibody (MAb) was previously shown to induce remission of Hodgkin's disease refractory to chemo- and radiotherapy through specific activation of natural killer (NK) cells, but the appearance of a human anti-mouse antibody (HAMA) response prevented its use for prolonged therapy. Here, we describe an effort to humanize the Fab arm directed against FcgammaRIII (CD16), which-in context with the previously humanized CD30 Fab fragment-provides the necessary component for the design of a clinically useful bispecific antibody. Thus, the CDRs of the anti-CD16 mouse IgG1/lambda MAb A9 were grafted onto human Ig sequences. In a first attempt, the murine V(lambda) domain was converted to a humanized lambda chain, which led, however, to complete loss of antigen-binding activity and extremely poor folding efficiency upon periplasmic expression in Escherichia coli. Hence, its CDRs were transplanted onto a human kappa light chain in a second attempt, which resulted in a functional recombinant Fab fragment, yet with 100-fold decreased antigen affinity. In the next step, an in vitro affinity maturation was performed, wherein random mutations were introduced into the humanized V(H) and V(kappa) domains through error-prone PCR, followed by a filter sandwich colony screening assay for increased binding activity towards the bacterially produced extracellular CD16 fragment. Finally, an optimized Fab fragment was obtained, which carries nine additional amino acid exchanges and exhibits an affinity that is within a factor of 2 identical to that of the original murine A9 Fab fragment. The resulting humanized Fab fragment was fully functional with respect to binding of the recombinant CD16 antigen in enzyme-linked immunosorbent assay and in cytofluorimetry with CD16-positive granulocytes, thus providing a promising starting point for the preparation of a fully human bispecific antibody that permits the therapeutic recruitment of NK cells.

  16. Dynamic processes in Be star atmospheres. 2: He I 2P-nD line formation in lambda Eridani (outburst)

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.; Hubeny, Ivan; Lanz, Thierry; Meylan, Thomas

    1994-01-01

    The He I lambda 6678 line of early Be stars generally shows violet (V) and red (R) emission whenever hydrogen alpha emission is present, but its use as a diagnostic has been handicapped by a poor understanding of the processes that drive it into emission. In an attempt to address this problem we obtained three series of eschelle spectra of the first two members of the singlet and triplet 2P-nD series of lambda Eri (B2e) during 1992 November 3-5 at Kitt Peak. During these observations lambda 6678 showed substantial emission variability in both the wings and central profile, providing an opportunity to compare its behavior with that of the lambda 4922, lambda 5876, and lambda 4471 lines. We found that the responses of the lines were different in several respects. Whereas the emissions in the V wings of all four lines scaled together, the R wing of the lambda 4922 line invariably responded with increased absorption whenever the R wing of lambda 6678 line showed increased emission. These same trends occurred within the central photospheric profiles. The R-wing behavior shows that much, but not all of the emission in lambda 6678 is caused by matter projected against the stellar disk. The excitation temperatures of the neighboring 2(sup 1) P transitions, lambda 6678 and lambda 4922 must be greater than and less than the photospheric continuum temperature, respectively. We have investigated departures from local thermodynamic equilibrium (LTE) for the He I spectrum in a variety of ad hoc, perturbed model atmospheres. We have found only one way to cause the source function of lambda 6678 to increase so strongly, namely, by increasing the atmospheric temperature in the line formation region to 30,000 - 40,000 K. This effect was discovered by Auer and Mihalas for O3-O4 atmospheric models, but it has not been applied to active B stars. Our models suggest that lambda 6678 emission in Be stars can be used as a sensitive monitor of localized hot spots on these stars' surfaces

  17. FORMING REALISTIC LATE-TYPE SPIRALS IN A {Lambda}CDM UNIVERSE: THE ERIS SIMULATION

    SciTech Connect

    Guedes, Javiera; Madau, Piero; Callegari, Simone; Mayer, Lucio

    2011-12-01

    Simulations of the formation of late-type spiral galaxies in a cold dark matter ({Lambda}CDM) universe have traditionally failed to yield realistic candidates. Here we report a new cosmological N-body/smooth particle hydrodynamic simulation of extreme dynamic range in which a close analog of a Milky Way disk galaxy arises naturally. Named 'Eris', the simulation follows the assembly of a galaxy halo of mass M{sub vir} = 7.9 Multiplication-Sign 10{sup 11} M{sub Sun} with a total of N = 18.6 million particles (gas + dark matter + stars) within the final virial radius, and a force resolution of 120 pc. It includes radiative cooling, heating from a cosmic UV field and supernova explosions (blastwave feedback), a star formation recipe based on a high gas density threshold (n{sub SF} = 5 atoms cm{sup -3} rather than the canonical n{sub SF} = 0.1 atoms cm{sup -3}), and neglects any feedback from an active galactic nucleus. Artificial images are generated to correctly compare simulations with observations. At the present epoch, the simulated galaxy has an extended rotationally supported disk with a radial scale length R{sub d} = 2.5 kpc, a gently falling rotation curve with circular velocity at 2.2 disk scale lengths of V{sub 2.2} = 214 km s{sup -1}, an i-band bulge-to-disk ratio B/D = 0.35, and a baryonic mass fraction within the virial radius that is 30% below the cosmic value. The disk is thin, has a typical H I-to-stellar mass ratio, is forming stars in the region of the {Sigma}{sub SFR}-{Sigma}{sub HI} plane occupied by spiral galaxies, and falls on the photometric Tully-Fisher and the stellar-mass-halo-virial-mass relations. Hot (T > 3 Multiplication-Sign 10{sup 5} K) X-ray luminous halo gas makes up only 26% of the universal baryon fraction and follows a 'flattened' density profile {proportional_to}r{sup -1.13} out to r = 100 kpc. Eris appears then to be the first cosmological hydrodynamic simulation in which the galaxy structural properties, the mass budget in the

  18. X-Ray Flare Characteristics in the B2e Star Lambda Eridani (ROSAT)

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.

    1997-01-01

    We document the results of a simultaneous wavelength monitoring on the B2e star (lambda) Eri. This campaign was carried out from ground stations and with the ROSAT, ASCA, IUE, and Voyager 2 space platforms during a week in February-March 1995; a smaller follow-up was conducted in September 1995. During the first of these intervals (lambda) Eri exhibited extraordinary wind and disk-ejection activity. The ROSAT/HRI X-ray light curves showed no large flares such as the one the ROSAT/PSCA observed in 1991. However, possible low level fluctuations in the February-March ROSAT data occurred at the same time as unusual activity in H(alpha) He I (lambda)6678, He II (lambda)1640, and the C IV doublet. For example, the hydrogen and helium lines exhibited an emission in the blue half of their profiles, probably lasting several hours. The C IV lines showed a strong high-velocity Discrete Absorption Component (DAC) accompanied by unusually strong absorption at lower velocities. The helium line activity suggests that a mass ejection occurred at the base of the wind while the strong C III (Voyager) and C IV (IUE) lines implies that shock interactions occurred in the wind flow. It is not clear that the X-ray elevations are directly related to the strong C IV absorptions because the former changed on a much more rapid timescale than absorptions in the C IV lines. Within hours of the mild X-ray flux variations found by ROSAT on February 28, the Voyager UVS observed a "ringing" that decayed over three 3-hr. cycles. The amplitude of these fluctuations was strong (50%) at (lambda)(lambda)950-1100, decreased rapidly with wavelength, and faded to nondetection longward of (lambda)1300. Various considerations indicate that these continuum variations were not due to an instrumental pathology in the UVS. Rather, they appear to be due to a time-dependent flux deficit in the (lambda)(lambda)950-1250 region. We outline a scenario in which a dense plasma structure over the star's surface is

  19. Studies of $\\Lambda n$ interaction through polarization observables for final-state interactions in exclusive $\\Lambda$ photoproduction off the deuteron

    SciTech Connect

    Ilieva, Yordanka; Cao, Tongtong; Zachariou, Nicholas

    2016-06-01

    Theoretical studies suggest that experimental observables for hyperon production reactions can place stringent constraints on the free parameters of hyperon-nucleon potentials, which are critical for the understanding of hypernuclear matter and neutron stars. Here we present preliminary experimental results for the polarization observables S, Py, Ox, Oz, Cx, and Cz for final-state interactions (FSI) in exclusive L photoproduction off the deuteron. The observables were obtained from data collected during the E06-103 (g13) experiment with the CEBAF Large Acceptance Spectrometer (CLAS) in Hall B at Jefferson Lab. The g13 experiment ran with unpolarized deuteron target and circularly- and linearly-polarized photon beams with energies between 0.5 GeV and 2.5 GeV and collected about 51010 events with multiple charged particles in the final state. To select the reaction of interest, the K+ and the L decay products, a proton and a negative pion, were detected in the CLAS. The missing-mass technique was used to identify exclusive hyperon photoproduction events. Final-state interaction events were selected by requesting that the reconstructed neutron has a momentum larger than 200 MeV/c. The large statistics of E06-103 provided statistically meaningful FSI event samples, which allow for the extraction of one- and two-fold differential single- and double-polarization observables. Here we present preliminary results for a set of six observables for photon energies between 0.9 GeV and 2.3 GeV and for several kinematic variables in the Ln center-of-mass frame. Our results are the very first estimates of polarization observables for FSI in hyperon photoproduction and will be used to constrain the free parameters of hyperon-nucleon potentials.

  20. {Lambda}-p femtoscopy in collisions of Ar+KCl at 1.76A GeV

    SciTech Connect

    Agakishiev, G.; Destefanis, M.; Gilardi, C.; Kirschner, D.; Kuehn, W.; Lange, J. S.; Metag, V.; Mishra, D.; Pechenova, O.; Spataro, S.; Spruck, B.; Balanda, A.; Dybczak, A.; Michalska, B.; Otwinowski, J.; Przygoda, W.; Salabura, P.; Trebacz, R.; Wisniowski, M.; Wojcik, T.

    2010-08-15

    Results on {Lambda}p femtoscopy are reported at the lowest energy so far. At a beam energy of 1.76A GeV, the reaction Ar+KCl was studied with the High Acceptance Di-Electron Spectrometer (HADES) at SIS18/GSI. A high-statistics and high-purity {Lambda} sample was collected, allowing for the investigation of {Lambda}p correlations at low relative momenta. The experimental correlation function is compared to corresponding model calculations allowing the determination of the space-time extent of the {Lambda}p emission source. The {Lambda}p source radius is found to be slightly smaller than the pp correlation radius for a similar collision system. The present {Lambda}p radius is significantly smaller than that found for Au+Au/Pb+Pb collisions in the AGS, SPS, and RHIC energy domains but larger than that observed for electroproduction from He. Taking into account all available data, we find the {Lambda}p source radius to increase almost linearly with the number of participants to the power of one-third.

  1. Detection of kappa and lambda light chain monoclonal proteins in human serum: automated immunoassay versus immunofixation electrophoresis.

    PubMed

    Jaskowski, Troy D; Litwin, Christine M; Hill, Harry R

    2006-02-01

    Recently, turbidimetric immunoassays for detecting and quantifying kappa and lambda free light chains (FLC) have become available and are promoted as being more sensitive than immunofixation electrophoresis (IFE) in detecting FLC monoclonal proteins. In this study, we assessed the ability of these turbidimetric assays to detect serum monoclonal proteins involving both free and heavy-chain-bound kappa and lambda light chains compared to standard immunofixation electrophoresis. Sera demonstrating a restricted band of protein migration (other than a definite M spike) by serum protein electrophoresis (SPE), which may represent early monoclonal proteins, were also examined. When compared to IFE, percent agreement, sensitivity, and specificity for the kappa-FLC and lambda-FLC were 94.6, 72.9, and 99.5% and 98.5, 91.4, and 99.7%, respectively, in detecting monoclonal proteins involving free and heavy-chain-bound light chains. The majority of sera (73.7%) demonstrating a restricted band of protein migration on SPE demonstrated abnormal IFE patterns suggestive of multiple myeloma or monoclonal gammopathy of unknown significance, but gave normal kappa/lambda FLC ratios using the turbidimetric immunoassays. In conclusion, the kappa and lambda FLC assays are significantly less sensitive (72.9 to 91.4%) than IFE, but specific in detecting serum monoclonal proteins. Moreover, the kappa/lambda ratio has little value in routine screening since the majority of sera with abnormal IFE patterns had normal kappa/lambda FLC ratios.

  2. Single-trial lambda wave identification using a fuzzy inference system and predictive statistical diagnosis

    NASA Astrophysics Data System (ADS)

    Saatchi, R.

    2004-03-01

    The aim of the study was to automate the identification of a saccade-related visual evoked potential (EP) called the lambda wave. The lambda waves were extracted from single trials of electroencephalogram (EEG) waveforms using independent component analysis (ICA). A trial was a set of EEG waveforms recorded from 64 scalp electrode locations while a saccade was performed. Forty saccade-related EEG trials (recorded from four normal subjects) were used in the study. The number of waveforms per trial was reduced from 64 to 22 by pre-processing. The application of ICA to the resulting waveforms produced 880 components (i.e. 4 subjects × 10 trials per subject × 22 components per trial). The components were divided into 373 lambda and 507 nonlambda waves by visual inspection and then they were represented by one spatial and two temporal features. The classification performance of a Bayesian approach called predictive statistical diagnosis (PSD) was compared with that of a fuzzy logic approach called a fuzzy inference system (FIS). The outputs from the two classification approaches were then combined and the resulting discrimination accuracy was evaluated. For each approach, half the data from the lambda and nonlambda wave categories were used to determine the operating parameters of the classification schemes while the rest (i.e. the validation set) were used to evaluate their classification accuracies. The sensitivity and specificity values when the classification approaches were applied to the lambda wave validation data set were as follows: for the PSD 92.51% and 91.73% respectively, for the FIS 95.72% and 89.76% respectively, and for the combined FIS and PSD approach 97.33% and 97.24% respectively (classification threshold was 0.5). The devised signal processing techniques together with the classification approaches provided for an effective extraction and classification of the single-trial lambda waves. However, as only four subjects were included, it will be

  3. Observations and Parameterizations of Particle Size Distributions in Deep Tropical Cirrus and Stratiform Precipitation Clouds: Results from In-Situ Observations in TRMM Field Campaigns

    NASA Technical Reports Server (NTRS)

    Heymsfield, Andrew J.; Bansemer, Aaron; Field, Paul R.; Durden, Stephen L.; Stith, Jeffrey L.; Dye, James E.; Hall, William; Grainger, Cedric A.

    2002-01-01

    In this study, we report on the evolution of particle size distributions (PSDs) and habits as measured during slow, Lagrangian-type spiral descents through deep subtropical and tropical cloud layers in Florida, Brazil, and Kwajalein, Marshall Islands, most of which were precipitating. The objective of the flight patterns was to learn more about how the PSDs evolved in the vertical and to obtain information of the vertical structure of microphysical properties. New instrumentation yielding better information on the concentrations of particles in the size (D) range between 0.2 and 2 cm, as well as improved particle imagery, produced more comprehensive observations for tropical stratiform precipitation regions and anvils than have been available previously. Collocated radar observations provided additional information on the vertical structure of the cloud layers sampled. Most of the spirals began at cloud top, with temperatures (T) as low as -50 C, and ended at cloud base or below the melting layer (ML). The PSDs broadened from cloud top towards cloud base, with the largest particles increasing in size from several millimeters at cloud top to one centimeter or larger towards cloud base. Some continued growth was noted in the upper part of the ML. Concentrations of particles less than 1 mm in size decreased with decreasing height. The result was a consistent change in the PSDs in the vertical. Similarly, systematic changes in the size dependence of the particle cross-sectional area was noted with decreasing height. Aggregation-as ascertained from both the changes in the PSDs and evolution of particle habits as observed in high detail with the cloud particle imager (CPI) probe-was responsible for these trends. The PSDs were generally well-represented by gamma distributions of the form N = N0 gamma D microns e- lambda gamma D that were fitted to the PSDs over 1-km horizontal intervals throughout the spirals. The intercept (N0 gamma), slope (lambda gamma), and dispersion

  4. Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.

    PubMed

    Nishida, Masayuki; Ida, Noriko; Horio, Mao; Takeuchi, Toshifumi; Kamisuki, Shinji; Murata, Hiroshi; Kuramochi, Kouji; Sugawara, Fumio; Yoshida, Hiromi; Mizushina, Yoshiyuki

    2008-05-01

    Hymenoic acid (1) is a natural compound isolated from cultures of a fungus, Hymenochaetaceae sp., and this structure was determined by spectroscopic analyses. Compound 1 is a novel sesquiterpene, trans-4-[(1'E,5'S)-5'-carboxy-1'-methyl-1'-hexenyl]cyclohexanecarboxylic acid. This compound selectively inhibited the activity of human DNA polymerase lambda (pol lambda) in vitro, and 50% inhibition was observed at a concentration of 91.7microM. Compound 1 did not influence the activities of the other seven mammalian pols (i.e., pols alpha, gamma, delta, epsilon, eta, iota, and kappa), but also showed no effect even on the activity of pol beta, which is thought to have a very similar three-dimensional structure to the pol beta-like region of pol lambda. This compound also did not inhibit the activities of prokaryotic pols and other DNA metabolic enzymes tested. These results suggested that compound 1 could be a selective inhibitor of eukaryotic pol lambda. This compound had no inhibitory activities against two N-terminal truncated pol lambda, del-1 pol lambda (lacking nuclear localization signal (NLS), BRCA1 C-terminus (BRCT) domain [residues 133-575]), and del-2 pol lambda (lacking NLS, BRCT, domain and proline-rich region [residues 245-575]). The compound 1-induced inhibition of intact pol lambda activity was non-competitive with respect to both the DNA template-primer and the dNTP substrate. On the basis of these results, the pol lambda inhibitory mechanism of compound 1 is discussed.

  5. Particle separation

    DOEpatents

    Moosmuller, Hans [Reno, NV; Chakrabarty, Rajan K [Reno, NV; Arnott, W Patrick [Reno, NV

    2011-04-26

    Embodiments of a method for selecting particles, such as based on their morphology, is disclosed. In a particular example, the particles are charged and acquire different amounts of charge, or have different charge distributions, based on their morphology. The particles are then sorted based on their flow properties. In a specific example, the particles are sorted using a differential mobility analyzer, which sorts particles, at least in part, based on their electrical mobility. Given a population of particles with similar electrical mobilities, the disclosed process can be used to sort particles based on the net charge carried by the particle, and thus, given the relationship between charge and morphology, separate the particles based on their morphology.

  6. Particle separation

    NASA Technical Reports Server (NTRS)

    Moosmuller, Hans (Inventor); Chakrabarty, Rajan K. (Inventor); Arnott, W. Patrick (Inventor)

    2011-01-01

    Embodiments of a method for selecting particles, such as based on their morphology, is disclosed. In a particular example, the particles are charged and acquire different amounts of charge, or have different charge distributions, based on their morphology. The particles are then sorted based on their flow properties. In a specific example, the particles are sorted using a differential mobility analyzer, which sorts particles, at least in part, based on their electrical mobility. Given a population of particles with similar electrical mobilities, the disclosed process can be used to sort particles based on the net charge carried by the particle, and thus, given the relationship between charge and morphology, separate the particles based on their morphology.

  7. HE I lambda4922 in B stars: Comparison of theory and observations

    SciTech Connect

    Heasley, J.N.; Wolfe, S.C.

    1981-05-01

    Profiles of the He I lambda4922 line have been observed in 15 B-type stars with an unintensified Reticon detector on the coude spectrograph of the University of Hawaii's 2.2 m telescope on Mauna Kea. The observations are compared with the theoretical line profiles computed by Mihalas, Barnard, Cooper, and Smith, who used an improved line broadening theory. The results show that the computed profiles reproduce the core and red wing of the stellar profiles, but the forbidden component in the blue wing of the line is deeper and broader than the theoretical predictions. Photographic H..cap alpha.. line profiles have been obtained for three of our program stars, and for this sample we find that the Balmer line, He I lambda4922, and Stroemgren photometric colors yield a consistent set of atmospheric parameters.

  8. Disappearance of Roton Propagation in Superfluid {sup 4}He at T{sub {lambda}}

    SciTech Connect

    Svensson, E.C.; Montfrooij, W.; de Schepper, I.M.

    1996-11-01

    Using neutron scattering, we determine the dynamic structure factor {ital S}({ital q},{nu}) of liquid {sup 4}He for the roton wave number {ital q}=2.0{sup {minus}1} as a function of frequency {nu} at constant density 0.1715 gcm{sup {minus}3} and for ten temperatures in the range 1.08{le}{ital T}{le}2.00 K, primarily near the superfluid transition temperature {ital T}{sub {lambda}}=1.9202 K. The {lambda} transition is marked by a complete softening of the roton mode and a rapid decrease in lifetime. This change is continuous with temperature, and we find no evidence for a new mode appearing as one enters the superfluid phase, as has been proposed on the basis of theoretical considerations. {copyright} {ital 1996 The American Physical Society.}

  9. Search for the Theta+ pentaquark in the gamma d -> Lambda n K+ reaction measured with CLAS

    SciTech Connect

    Silvia Niccolai; Marco Mirazita; Patrizia Rossi; Nathan Baltzell; Daniel Carman; Kenneth Hicks; Bryan McKinnon; Tsutomu Mibe; Stepan Stepanyan; David Tedeschi; Gary Adams; Pawel Ambrozewicz; Sergio Pereira; Marco Anghinolfi; Gegham Asryan; Harutyun AVAKIAN; H. Bagdasaryan; Nathan Baillie; Jacques Ball; V. Batourine; Marco Battaglieri; Ivan Bedlinski; Ivan Bedlinskiy; Ivan Bedlinski; Ivan Bedlinskiy; Mehmet Bektasoglu; Matthew Bellis; Nawal Benmouna; Barry Berman; Angela Biselli; Sergey Boyarinov; Sylvain Bouchigny; Robert Bradford; Derek Branford; William Briscoe; William Brooks; Stephen Bueltmann; Volker Burkert; Cornel Butuceanu; John Calarco; S.L. Careccia; Bryan Carnahan; Shifeng Chen; Philip Cole; Patrick Collins; Philip Coltharp; Donald Crabb; Hall Crannell; V. Crede; John Cummings; Natalya Dashyan; Pavel Degtiarenko; Rita De Masi; Airton Deppman; Enzo De Sanctis; Alexandre Deur; Raffaella De Vita; Kahanawita Dharmawardane; Chaden Djalali; Gail Dodge; Joseph Donnelly; David Doughty; Michael Dugger; Oleksandr Dzyubak; Hovanes Egiyan; Kim Egiyan; L. El Fassi; Latifa Elouadrhiri; Paul Eugenio; Gleb Fedotov; Gerald Feldman; Herbert Funsten; Michel Garcon; Gagik Gavalian; Gerard Gilfoyle; Kevin Giovanetti; Francois-Xavier Girod; John Goetz; Atilla Gonenc; Christopher Gordon; Ralf Gothe; Keith Griffioen; Michel Guidal; Nevzat Guler; Lei Guo; Vardan Gyurjyan; Cynthia Hadjidakis; Kawtar Hafidi; Hayk Hakobyan; Rafael Hakobyan; John Hardie; F. Hersman; Ishaq Hleiqawi; Maurik Holtrop; Charles Hyde-Wright; Yordanka Ilieva; David Ireland; Boris Ishkhanov; Eugeny Isupov; Mark Ito; David Jenkins; Hyon-Suk Jo; Kyungseon Joo; Henry Juengst; James Kellie; Mahbubul Khandaker; Wooyoung Kim; Andreas Klein; Franz Klein; Alexei Klimenko; Mikhail Kossov; Laird Kramer; V. Kubarovsky; Joachim Kuhn; Sebastian Kuhn; Sergey Kuleshov; Jeff Lachniet; Jorn Langheinrich; David Lawrence; Tsung-shung Lee; Kenneth Livingston; H. Lu; Marion MacCormick; Nikolai Markov; Bernhard Mecking; Jonathan Mellor; Joseph Melone; Mac Mestayer; Curtis Meyer; Konstantin Mikhaylov; Ralph Minehart; Rory Miskimen; Viktor Mokeev; Ludyvine Morand; Steven Morrow; Maryam Moteabbed; Gordon Mutchler; Pawel Nadel-Turonski; James Napolitano; Rakhsha Nasseripour; Gabriel Niculescu; Maria-Ioana Niculescu; Bogdan Niczyporuk; Megh Niroula; Rustam Niyazov; Mina Nozar; Jorge De Olivei Echeimberg; Mikhail Osipenko; Alexander Ostrovidov; K. Park; Evgueni Pasyuk; Craig Paterson; Joshua Pierce; Nikolay Pivnyuk; Dinko Pocanic; Oleg Pogorelko; Sergey Pozdnyakov; Barry Preedom; John Price; Yelena Prok; Dan Protopopescu; Brian Raue; Gregory Riccardi; Giovanni Ricco; Marco Ripani; Barry Ritchie; Federico Ronchetti; Guenther Rosner; Franck Sabatie; Carlos Salgado; Joseph Santoro; Vladimir Sapunenko; Reinhard Schumacher; Vladimir Serov; Youri Sharabian; Nikolay Shvedunov; Elton Smith; Lee Smith; Daniel Sober; Aleksey Stavinskiy; Stepan Stepanyan; Burnham Stokes; Paul Stoler; Igor Strakovski; Steffen Strauch; Mauro Taiuti; Ulrike Thoma; Avtandil Tkabladze; Svyatoslav Tkachenko; Luminita Todor; Clarisse Tur; Maurizio Ungaro; Michael Vineyard; Alexander Vlassov; Daniel Watts; Lawrence Weinstein; Dennis Weygand; M. Williams; Elliott Wolin; Michael Wood; Amrit Yegneswaran; Lorenzo Zana; Jixie Zhang; Bo Zhao; Zhiwen Zhao

    2006-04-26

    For the first time, the reaction gamma d -> Lambda n K+ has been analyzed in order to search for the exotic pentaquark baryon Theta+(1540). The data were taken at Jefferson Lab, using the Hall-B tagged-photon beam of energy between 0.8 and 3.6 GeV and the CEBAF Large Acceptance Spectrometer (CLAS). No statistically significant structures were observed in the nK+ invariant mass distribution. The upper limit on the gamma d -> Lambda Theta+ integrated cross section has been calculated and found to be between 5 and 25 nb, depending on the production model assumed. The upper limit on the differential cross section is also reported.

  10. Yang Baxter and anisotropic sigma and lambda models, cyclic RG and exact S-matrices

    NASA Astrophysics Data System (ADS)

    Appadu, Calan; Hollowood, Timothy J.; Price, Dafydd; Thompson, Daniel C.

    2017-09-01

    Integrable deformation of SU(2) sigma and lambda models are considered at the classical and quantum levels. These are the Yang-Baxter and XXZ-type anisotropic deformations. The XXZ type deformations are UV safe in one regime, while in another regime, like the Yang-Baxter deformations, they exhibit cyclic RG behaviour. The associ-ated affine quantum group symmetry, realized classically at the Poisson bracket level, has q a complex phase in the UV safe regime and q real in the cyclic RG regime, where q is an RG invariant. Based on the symmetries and RG flow we propose exact factorizable S-matrices to describe the scattering of states in the lambda models, from which the sigma models follow by taking a limit and non-abelian T-duality. In the cyclic RG regimes, the S-matrices are periodic functions of rapidity, at large rapidity, and in the Yang-Baxter case violate parity.

  11. Lambda Excision Revisited: Testing a Model for Synapsis of Prophage Ends

    PubMed Central

    Pato, Martin L.

    2001-01-01

    Excision of lambda prophage was reexamined to test a model for prophage end synapsis. The model proposes that, during in situ prophage replication, following induction, the diverging replication forks are held together. Consequently, prophage DNA is spooled through the replication machinery, drawing the prophage ends together and facilitating synapsis. The model predicts that excision will be slowed if in situ lambda replication is inhibited, and the predicted low rate of excision of a nonreplicating prophage was observed after thermoinduction. However, excision was rapid if additional Int protein was supplied or if the temperature was reduced after induction, showing that (i) Int is partially thermosensitive for excision at 42°C and (ii) in situ replication is not required for rapid excision, a finding that is inconsistent with the model. PMID:11489876

  12. Cloning of the lambda resistant genes from Brevibacterium albidum and Proteus vulgaris into Escherichia coli.

    PubMed

    Chae, K S; Yoo, O J

    1986-11-14

    Genes from Proteus vulgaris ATCC13315 and Brevibacterium albidum ATCC15831 were introduced into Escherichia coli, which rendered the host resistant to coliphage lambda. The clones transformed by any one of the two recombinant plasmids, pRMG101 or pRMG216, were totally resistant against the infection of virulent lambda and N4, but sensitive to ø80, T4 and T7. However, when maltose transport systems of the clones were induced by maltose, the clones were no more resistant to the phage: thus, this phenotype was thought to be due to the inhibition of phage adsorption onto the cell surface. The gene product was shown by SDS-PAGE of membrane protein-enriched extract of the clone. Molecular weight as measured was about 40,000 dalton, which coincide with that inferred from the nucleotide sequences.

  13. Simultaneous IUE and VLA observations of YZ Canis Minoris, Ad Leonis and Lambda Andromedae

    NASA Technical Reports Server (NTRS)

    Willson, Robert F.; Lang, Kenneth R.

    1986-01-01

    The IUE and VLA simultaneously observed the dwarf M flare stars YZ Canis Minoris and AD Leonis, and the RS CVn star Lambda Andromedae. Narrow-band, slowly varying radiation near 20cm wavelength was detected from YZ Canis Minoris. The radiation cannot be attributed to conventional emission processes, but may be explained by a coherent emission mechanism. The Mg II h and k line intensities also underwent changes in intensity, although the connection between the microwave and ultraviolet variations is unclear. Impulsive microwave bursts were detected from AD Leonis, but there were no significant variations in the Mg II line intensities. Enhancements in several ultraviolet emission lines were detected on timescales of 1 hr from Lambda Andromedae without accompanying variations at 6cm or 20cm wavelength.

  14. On the electrical conductivity of lambda DNA at micron length-scales

    NASA Astrophysics Data System (ADS)

    Zhang, Y.; Austin, R. H.; Ong, N. P.; Cox, E. C.

    2002-03-01

    Recent experiments on the DC electrical conductivity of DNA yield a baffling array of results, from metallic conductivity to insulating behavior. We have concentrated on optimizing by chemical methods the direct binding of lambda DNA molecules to Au electrodes for two-probe I-V measurements. To achieve direct binding of the DNA base-pair stack to Au, we incorporated thiol-modified nucleotides into both DNA ends using a DNA polymerase modified to eliminate its exonuclease activities (the Klenow fragment, 3'arrow 5' exo-). We will show videos of DNA bound to electrodes in a flowing buffer solution, and evidence for and against specific chemical binding between the DNA and Au. Our present result is that, at room temperature, lambda DNA is an insulator on the micron scale ( ρ > 10^6 Ω \\cdot cm ).

  15. Rate of degradation of lambda-cyhalothrin and methomyl in grapes (Vitis vinifera L.).

    PubMed

    Banerjee, Kaushik; Upadhyay, Ajay Kumar; Adsule, Pandurang G; Patil, Sangram H; Oulkar, Dasharath P; Jadhav, Deepak R

    2006-10-01

    Rates of degradation of lambda-cyhalothrin and methomyl residues in grape are reported. The dissipation behavior of both insecticides followed first-order rate kinetics with similar patterns at standard and double-dose applications. Residues of lambda-cyhalothrin were lost with pre-harvest intervals (PHI) of 12.0-12.5 and 15.0-15.5 days, corresponding to the applications at 25 and 50 g a.i. ha-1, respectively. In the case of methomyl, residues were lost with PHI of 55.0 and 61.0 days, following applications at 1 and 2 kg a.i. ha-1, respectively. The PHI, recommended on the basis of the experimental results, was shown to be effective in minimizing residue load of these insecticides below their maximum residue limits (MRLs) in vineyard samples.

  16. Second order gravitational effects on CMB temperature anisotropy in {lambda} dominated flat universes

    SciTech Connect

    Tomita, Kenji; Inoue, Kaiki Taro

    2008-05-15

    We study second order gravitational effects of local inhomogeneities on the cosmic microwave background radiation in flat universes with matter and a cosmological constant {lambda}. We find that the general relativistic correction to the Newtonian approximation is negligible at second order provided that the size of the inhomogeneous region is sufficiently smaller than the horizon scale. For a spherically symmetric top-hat type quasilinear perturbation, the first order temperature fluctuation corresponding to the linear integrated Sachs-Wolfe effect is enhanced (suppressed) by the second order one for a compensated void (lump). As a function of redshift of the local inhomogeneity, the second order temperature fluctuations due to evolution of the gravitational potential have a peak before the matter-{lambda} equality epoch for a fixed comoving size and a density contrast. The second order gravitational effects from local quasilinear inhomogeneities at a redshift z{approx}1 may significantly affect the cosmic microwave background.

  17. Uveal effusion associated with an IgM lambda subtype monoclonal gammopathy.

    PubMed

    Khaouly, S; Vilaplana, D

    2014-09-01

    A 68-year-old man was referred to the hospital with progressive decreased vision in the right eye over the past year. A moderate cataract and annular choroidal thickening were found. The diagnosis of uveal effusion was confirmed by ultrasound and fluorescein and indocyanine green angiography. Laboratory studies showed an IgM lambda subtype monoclonal gammopathy of undetermined significance. The patient underwent cataract surgery, and a sub-Tenon's triamcinolone injection with a satisfactory short-term outcome. This association has not been previously reported, and it shows that IgM lambda subtype monoclonal gammopathy of undetermined significance should be added to the list of disorders associated with uveal effusion. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  18. The formation process of the He I lambda 10830 line in cool giant stars

    NASA Technical Reports Server (NTRS)

    Luttermoser, Donald G.

    1993-01-01

    The Final Report on the formation process of the He I lambda 10830 line in cool giant stars is presented. The research involves observing a sample of cool giant stars with ROSAT. These stars were selected from the list of bright stars which display He I lambda 10830 in absorption or emission and lie on the cool side of the coronal dividing line. With measured x ray fluxes or upper limits measured by the Position Sensitive Proportional Counter (PSPC), the role x rays play in the formation of this important line was investigated using the non-LTE radiative transfer code PANDORA. Hydrodynamic calculations were performed to investigate the contributions of acoustic wave heating in the formation of this line as well.

  19. An analysis of the openehr archetype semantics based on a typed lambda theory.

    PubMed

    Tatsukawa, Akimichi; Shinohara, Emiko Y; Kawazoe, Yoshimasa; Imai, Takeshi; Ohe, Kazuhiko

    2013-01-01

    The openEHR has adopted the dual model architecture consisting of Reference Model and Archetype. The specification, however, lacks formal definitions of archetype semantics, so that its behaviors have remained ambiguous. The objective of this poster is to analyze semantics of the openEHR archetypes: its variance and mutability. We use a typed lambda calculus as an analyzing tool. As a result, we have reached the conclusion that archetypes should be 1) covariant and 2) immutable schema.

  20. Diquarks and the semileptonic decay of {lambda}{sub b} in the hybrid scheme

    SciTech Connect

    Guo Peng; Ke Hongwei; Li Xueqian; Lue Caidian; Wang Yuming

    2007-03-01

    In this work we use the heavy-quark-light-diquark picture to study the semileptonic decay {lambda}{sub b}{yields}{lambda}{sub c}+l+{nu}{sub l} in the so-called hybrid scheme. Namely, we apply the heavy quark effective theory (HQET) for larger q{sup 2} (corresponding to small recoil), which is the invariant mass square of l+{nu}, whereas the perturbative QCD approach for smaller q{sup 2} to calculate the form factors. The turning point where we require the form factors derived in the two approaches to be connected, is chosen near {rho}{sub cut}=1.1. It is noted that the kinematic parameter {rho} which is usually adopted in the perturbative QCD approach, is in fact exactly the same as the recoil factor {omega}=v{center_dot}v{sup '} used in HQET where v, v{sup '} are the four velocities of {lambda}{sub b} and {lambda}{sub c} respectively. We find that the final result is not very sensitive to the choice, so that it is relatively reliable. Moreover, we apply a proper numerical program within a small range around {rho}{sub cut} to make the connection sufficiently smooth and we parametrize the form factor by fitting the curve gained in the hybrid scheme. The expression and involved parameters can be compared with the ones gained by fitting the experimental data. In this scheme the end-point singularities do not appear at all. The calculated value is satisfactorily consistent with the data which is recently measured by the DELPHI collaboration within 2 standard deviations.

  1. Feasibility of constructing an absorption cell tuned to lambda = 1315 nm

    SciTech Connect

    Danilov, O.B.; Zhevlakov, A.P.; Yachnev, I.L.

    1981-06-01

    Experiments indicated that the concentration of nonexcited iodine atoms during the pyrolysis stage of the photolysis of perfluoroalkyl iodides could reach (2--5) x 10/sup 17/ cm/sup -3/. The velocities of pyrolysis and compression waves were determined in a thick perfluoroalkyl iodide layer. The pyrolysis wave was considerably faster than the compression wave. An analysis was made of the possibility of using a pyrolysis wave to create a medium absorbing at lambda = 1315 nm in a flash absorption cell.

  2. Primary endobronchial plasmacytoma involving local lymph nodes and presenting with rare immunoglobulin G lambda monoclonal gammopathy

    PubMed Central

    Wei, Sen; Li, Xin; Song, Zuoqing; Zhao, Honglin; Qiu, Xiaomin; Gong, Lei; Chen, Jun; Zhou, Qinghua

    2012-01-01

    Extramedullary plasmacytoma occurring as a primary pulmonary lesion is rare. The present report describes a 42-year-old Chinese man diagnosed with primary pulmonary plasmacytoma following left lower lobectomy. Of note, an extremely rare immunoglobulin G lambda paraprotein was documented in the patient’s serum by immunofixation electrophoresis. The patient has been well, showing no local recurrence or multifocal disease during a 15-month follow-up. PMID:22679619

  3. Topological relationship of prophage lambda to the bacterial chromosome in lysogenic cells.

    PubMed

    Freifelder, D; Meselson, M

    1970-01-01

    X irradiation converts bacterial sex factor DNA covalent circles to more slowly sedimenting forms according to first order kinetics. The rate of conversion is greater for sex factors carrying lambda prophage than it is for nonlysogenized sex factors. The magnitude of the difference and the absence of covalent circular DNA from the product show that the prophage DNA is linearly inserted into the sex factor, as predicted by Campbell's model for lysogenization.

  4. Photospheric Activity in Selected Be STARS: lambda Eri and gamma Cas

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.

    1994-01-01

    Recent observations of rapid variations in optical He I lines, X-rays, and FUV wavelengths in the prototypical classical Be stars lambda Eri and star gamma Cas hint that the violent processes occur on the surfaces of these stars almost all the time. We suggest that of these phenomena show greater similarities with magnetic flaring than any other process through to occur on stars.

  5. Electroproduction of strangeness on (Lambda)H-3,4 bound states on helium

    SciTech Connect

    F. Dohrmann; D. Abbott; A. Ahmidouch; P. Ambrozewicz; C. S. Armstrong; J. Arrington; R. Asaturyan; K. Assamagan; S. Avery; K. Bailey; S. Beedoe; H. Bitao; H. Breuer; D. S. Brown; R. Carlini; J. Cha; N. Chant; E. Christy; A. Cochran; L. Cole; G. Collins; C. Cothran; J. Crowder; W. J. Cummings; S. Danagoulian; F. Duncan; J. Dunne; D. Dutta; T. Eden; M. Elaasar; R. Ent; L. Ewell; H. Fenker; H. T. Fortune; Y. Fujii; L. Gan; H. Gao; K. Garrow; D. F. Geesaman; P. Gueye; K. Gustafsson; K. Hafidi; J. O. Hansen; W. Hinton; H. E. Jackson; H. Juengst; C. Keppel; A. Klein; D. Koltenuk; Y. Liang; J. H. Liu; A. Lung; D. Mack; R. Madey; P. Markowitz; C. J. Martoff; D. Meekins; J. Mitchell; T. Miyoshi; H. Mkrtchyan; R. Mohring; S. K. Mtingwa; B. Mueller; T. G. O'Neill; G. Niculescu; I. Niculescu; D. Potterveld; J. W. Price; B. A. Raue; P. E. Reimer; J. Reinhold; J. Roche; P. Roos; M. Sarsour; Y. Sato; G. Savage; R. Sawafta; R. E. Segel; A. Yu. Semenov; S. Stepanyan; V. Tadevosian; S. Tajima; L. Tang; B. Terburg; A. Uzzle; S. Wood; H. Yamaguchi; C. Yan; C. Yan; L. Yuan; M. Zeier; B. Zeidman; B. Zihlmann

    2005-05-01

    The A(e,eK+)X reaction has been investigated at Jefferson Laboratory. Data were taken for Q{sup 2} approx. 0.35 GeV{sup 2} at a beam energy of 3.245 GeV for 1H,3He and 4He targets. Evidence for Lambda-hypernuclear bound states is seen for 3,4He targets. This is the first time that the electroproduction of these hypernuclei has been observed.

  6. Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.

    PubMed

    Mattiacio, Jonelle L; Brewer, Matt; Dewhurst, Stephen

    2017-01-01

    The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like scaffold provided by the lambda phage capsid. Phage vectors, in general, have advantages over mammalian virus vectors due to their genetic tractability, inexpensive production, suitability for scale-up, as well as their physical stability, making them an attractive vaccine platform.

  7. Deposition of kappa and lambda light chains in amyloid filaments of dialysis-related amyloidosis.

    PubMed

    Brancaccio, D; Ghiggeri, G M; Braidotti, P; Garberi, A; Gallieni, M; Bellotti, V; Zoni, U; Gusmano, R; Coggi, G

    1995-10-01

    beta 2-Microglobulin (beta 2m) is considered to be the amyloidogenic precursor in dialysis-related amyloidosis, although the implication of other relevant cofactors in the pathogenesis of this disease has also been hypothesized. It is conceivable that substances found in amyloid deposits might represent something more than simple codeposition, possibly playing a pathogenic role in amyloidogenesis. Along these lines, a detailed analysis of the protein composition of amyloid fibrils purified from synovial material surgically obtained from nine patients on long-term dialysis was carried out. By the use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, several other protein components, in addition to beta 2m, were found. These were characterized by NH2 amino-terminal sequencing and immunoblotting. In fibrils obtained by water extraction, which fulfill the electron microscopy criteria of highly pure amyloid material, polyclonal kappa and lambda light chains were detected with a concentration of 15 micrograms/mL in the water extraction material; the beta 2m concentration was 200 micrograms/mL. Light microscopy immunohistochemistry was performed on samples from five patients. Amyloid deposits reacted with anti-beta 2m, and anti-light (kappa, lambda), chain antibodies. The immunoreaction of amyloid filaments to anti-beta 2m, anti-lambda, and anti-kappa light chain antibodies was also tested by electron microscopy by use of the immunogold staining procedure. Amyloid filaments were labeled by the three antibodies and showed a different intensity of immunostaining apparently related to their different aggregation pattern. These observations demonstrate that polyclonal immunoglobulin light chains (kappa and lambda) are not contaminants but, together with beta 2m, represent a major constituent of amyloid deposits in dialysis-related osteoarticular amyloidosis, thus indicating their possible role in amyloidogenesis.

  8. Finite-geometry specific-heat scaling function near the lambda transition

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, S.; Bhattacharjee, J. K.

    1998-07-01

    Using a technique due to Nicoll for studying the wave-number dependent specific heat in the bulk geometry, we calculate for temperatures above the lambda point the two-loop specific-heat scaling function for the parallel plate geometry with Dirichlet boundary conditions. We work with the logarithmic specific heat for simplicity, since for the actual superfluid transition the exponent α is very close to zero. The agreement with the recent data is exhibited.

  9. Measurement of the $\\Sigma \\pi$ photoproduction line shapes near the $\\Lambda(1405)$

    SciTech Connect

    Moriya, K; Adhikari, K P; Adikaram, D; Aghasyan, M; Anderson, M D; Anefalos Pereira, S; Ball, J; Baltzell, N A; Battaglieri, M; Batourine, V; Bedlinskiy, I; Bellis, M; Biselli, A S; Bono, J; Boiarinov, S; Briscoe, W J; Burkert, V D; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Cole, P L; Collins, P; Crede, V; D'Angelo, A; Dashyan, N; De Sanctis, E; De Vita, R; Deur, A; Dey, B; Djalali, C; Doughty, R; Dupre, R; Egiyan, H; El Fassi, L; Eugenio, P; Fedotov, G; Fegan, S; Fersch, R; Fleming, J A; Gevorgyan, N; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Goetz, J T; Gohn, W; Golovatch, E; Gothe, R W; Griffioen, K A; Guidal, M; Hafidi, K; Hakobyan, H; Hanretty, C; Harrison, N; Heddle, D; Hicks, K; Ho, D; Holtrop, M; Hyde, C E; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Jo, H S; Keller, D; Khandaker, M; Khertarpal, P; Kim, A; Kim, W; Klein, A; Klein, F J; Koirala, S; Kubarovsky, A; Kubarovsky, V; Kuleshov, S V; Kvaltine, N D; Livingston, K; Lu, H Y; MacGregor, I.J. D; Markov, N; Mayer, M; McCracken, M; McKinnon, B; Mestayer, M D; Meyer, C A; Mirazita, M; Mineeva, T; Mokeev, V; Montgomery, R A; Munevar, E; Munoz Camacho, C; Nadel-Turonski, P; Nasseripour, R; Nepali, C S; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Pappalardo, L L; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Phelps, E; Phillips, J J; Pisano, S; Pivnyuk, N; Pogorelko, O; Pozdniakov, S; Price, J W; Procureur, S; Protopopescu, D; Rimal, D; Ripani, M; Ritchie, B G; Rosner, G; Rossi, P; Sabatio, F; Saini, M S; Salgado, C; Schott, D; Seder, E; Seraydaryan, H; Sharabian, Y G; Smith, E S; Smith, G D; Sober, D I; Stepanyan, S S; Stepanyan, S; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Tang, W; Taylor, S; Taylor, C E; Tian, Ye; Tkachenko, S; Torayev, B; Ungaro, M; Vernarsky, B; Vlassov, A V; Voskanyan, H; Voutier, E; Walford, N K; Watts, D P; Weygand, D P

    2013-03-01

    The reaction {gamma} + p -> K{sup +} + {Sigma} + {p}i was used to determine the invariant mass distributions or "line shapes" of the {Sigma}{sup +} {pi}{sup -}, {Sigma}{sup -} {pi}{sup +} and {Sigma}{sup 0} {pi}{sup 0} final states, from threshold at 1328 MeV/c^2 through the mass range of the {Lambda}(1405) and the {Lambda}(1520). The measurements were made with the CLAS system at Jefferson Lab using tagged real photons, for center-of-mass energies 1.95 < W < 2.85 GeV. The three mass distributions differ strongly in the vicinity of the I=0 {Lambda}(1405), indicating the presence of substantial I=1 strength in the reaction. Background contributions to the data from the {Sigma}{sup 0}(1385) and from K* {Sigma} production were studied and shown to have negligible influence. To separate the isospin amplitudes, Breit-Wigner model fits were made that included channel-coupling distortions due to the Nkbar threshold. A best fit to all the data was obtained after including a phenomenological I=1, J{sup P} = 1/2{sup -} amplitude with a centroid at 1394\\pm20 MeV/c^2 and a second I=1 amplitude at 1413\\pm10 MeV/c^2. The centroid of the I=0 {Lambda}(1405) strength was found at the {Sigma} {pi} threshold, with the observed shape determined largely by channel-coupling, leading to an apparent overall peak near 1405 MeV/c^2.

  10. On the affinities of lambda 5778 and other broad diffuse interstellar bands

    NASA Technical Reports Server (NTRS)

    Mcintosh, Alan; Webster, Adrian

    1994-01-01

    The authors examined the broad band 5778 A because of the quantity and quality of data that exists in literature. To investigate the affinity of that band with the bands of Family 1, the ratio W(sub lambda)(4430)/W(sub lambda)(5797) was formed. If the two band belong to the same family then the ratio should be a constant from star to star and it should not be possible to find an independent variable with which the ratio is correlated. If, however, a variable is found which does produce a statistically significant correlation with the ratio of equivalent widths then the bands cannot be in the same family. To test the affinity of the band at 5778 A with the other families the procedure was repeated using the bands at 5780 and 5787 A as being representative of Families 2 and 3 respectively. The measurement results of this test are shown using 21 stars taken from Herbig. Statistically significant correlations resulted when the band at 5778 A was tested against the bands of Families 1 and 2 but there was no correlation with Family 3. It is concluded that lambda 5778 is unlikely a member of Family 1 and so all the broad bands do not have their origin in a single carrier. Also, lambda 5778 does not appear to be a member of Family 2 either, but may be a member of Family 3. It appears that either a single carrier can be the origin of both broad and narrow bands or that the bands are produced by different carriers which exist in similar interstellar habitats. This latter possibility would require the introduction of a fourth family of bands.

  11. Theory of sub-Doppler cooling of three-level {Lambda} atoms in standing light waves

    SciTech Connect

    Kosachev, D.V.; Rozhdestvenskii, Yu.V.

    1994-12-01

    A general theory of cooling of three-level {Lambda} atoms in two standing light waves between which there is a relative spatial phase shift is presented for arbitrary ratios of the intensity and detuning. It is shown that in the case of equal detuning of the light waves, deep (sub-Doppler) cooling of three-level atoms occurs for any values of the spatial phase shift. For zero spatial phase shift, the atoms are strongly cooled due to coherent population trapping in the given atom-field interaction scheme. On the other hand, for the case of different frequency detunings, sub-Doppler cooling of {Lambda} atoms is possible only with a nonzero relative phase shift; it is shown that this is associated with the so-called {open_quotes}Sisyphus{close_quotes} cooling mechanism. The authors underscore that in their scheme neither a polarization gradient of the exciting waves nor a magnetic field is required to achieve this type of cooling pattern; two standing waves acting on different transitions of a {Lambda} atom are sufficient. 13 refs., 10 figs.

  12. Efficacy of alpha-cypermethrin and lambda-cyhalothrin applications to prevent Aedes breeding in tires.

    PubMed

    Pettit, William J; Whelan, Peter I; McDonnell, Joseph; Jacups, Susan P

    2010-12-01

    The efficacy of alpha-cypermethrin (Cyperthor) and lambda-cyhalothrin (Demand) to prevent mosquito larval colonization of water-containing receptacles was investigated using 2 differing applications in disused car tires in Darwin, Australia. Insecticide treatments were applied uniformly to the inside surfaces of 2 categories of tires: 1) dry tires that were partially filled with water 24 h after spraying and 2) wet tires partially filled with water prior to spraying. All mosquito larvae, pupae, and dead adults were collected from the treatment and control tires weekly over the 24-wk study period and were later identified to species in the laboratory. Control tires were colonized by Aedes notoscriptus in wk 2 and by Culex quinquefasciatus in wk 4. Aedes notoscriptus failed to colonize any alpha-cypermethrin-treated tires until wk 22 and did not colonize any lambda-cyhalothrin-treated tires during the 24-wk trial. Culex quinquefasciatus colonized alpha-cypermethrin and lambda-cyhalothrin-treated tires from wk 11 and wk 15, respectively. These results indicate both insecticides using either application method can prevent colonization of Ae. notoscriptus for at least 20 wk and demonstrate great potential for the prevention of breeding in receptacles for other receptacle-breeding Aedes species, such as the dengue vectors, Ae. aegypti and Ae. albopictus.

  13. Pulsation of the lambda Bootis stars HD 111786 and HD 142994

    NASA Astrophysics Data System (ADS)

    Paunzen, E.; Weiss, W. W.; Martinez, P.; Matthews, J. M.; Pamyatnykh, A. A.; Kuschnig, R.

    1998-02-01

    The detection of possible nonradial pulsation modes among some lambda Bootis stars offers the prospect of using asteroseismology to determine their masses and ages, thereby testing competing theories for the origin of their chemical peculiarities. As a step toward this goal, we conducted multi-site photometric campaigns spanning two weeks each for two lambda Bootis stars already known to show oscillations with periods from 0.75 to 4 hr: HD 111786} \\def\\2{HD 142994 and \\2. Comparison of the observed eigenfrequency spectrum with model eigenmode spectra can constrain the age of the star. Since two of the main proposed mechanisms for the lambda Bootis phenomenon (mass loss coupled with diffusion, and accretion) predict widely different stellar ages, such an analysis could distinguish between these options. Frequency analysis of campaign data yielded four frequencies for each program star. The best matches of our observed eigenfrequencies to Main Sequence stellar models (which include the effects of rotation on the stellar structure and the pulsation modes) suggest that both stars are too far from the Zero-Age Main Sequence, to be consistent with the widely favoured accretion scenario. However, we caution that the results are preliminary and suggest future observing strategies to confirm/deny this finding. Based on observations obtained at CTIO, SAAO and with the Hipparcos satellite

  14. Effect of lambda-carrageenan-induced inflammatory pain on brain uptake of codeine and antinociception.

    PubMed

    Hau, Vincent S; Huber, Jason D; Campos, Christopher R; Davis, Ryan T; Davis, Thomas P

    2004-08-27

    This study investigated the potential clinical implications of lambda-carrageenan-induced inflammatory pain on brain uptake of a commonly used analgesic, codeine, in relation to the fundamental properties of the blood-brain barrier (BBB) correlated to its antinociceptive profile over a 168-h time course. BBB uptake of [14C]sucrose (a membrane impermeant marker) and [3H]codeine were investigated using an in situ brain perfusion model in the rat. Results demonstrated a significantly increased brain uptake of [14C]sucrose at 1, 3, 6 and 48 h (139+/-9%, 166+/-19%, 138+/-13% and 146+/-7% compared with control, respectively) and [3H]codeine at 3 and 48 h (179+/-6% and 179+/-12% compared with control, respectively). Capillary depletion analyses ensured that increased radioisotope associated with the brain was due to increased uptake rather than trapping in the cerebral vasculature. Antinociception studies using a radiant-heat tail flick analgesia method demonstrated that lambda-carrageenan-induced inflammatory pain enhanced the in vivo antinociceptive profile of i.p.-administered codeine (7 mg/kg) at 3 and 48 h (144+/-11% and 155+/-9% compared with control, respectively). This study demonstrated that brain uptake and antinociception of codeine are increased during lambda-carrageenan-induced inflammatory pain, suggesting that the presence of inflammatory pain may be an important consideration in therapeutic drug dosing, potential adverse effects and/or neurotoxicity.

  15. Observation of the decay B0bar -> LambdaC antiproton pi0

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Frascati /INFN, Genoa /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /INFN, Pisa /Princeton U. /Frascati /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /INFN, Trieste /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2010-08-26

    In a sample of 467 million B{bar B} pairs collected with the BABAR detector at the PEP-II collider at SLAC we have observed the decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar p}{pi}{sup 0} and measured the branching fraction to be (1.94 {+-} 0.17 {+-} 0.14 {+-} 0.50) x 10{sup -4}, where the uncertainties are statistical, systematic, and the uncertainty on the {Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +} branching fraction, respectively. We determine an upper limit of 1.5 x 10{sup -6} at 90% C.L. for the product branching fraction {Beta}({bar B}{sup 0} {yields} {Sigma}{sub c}{sup +}(2455){bar p}) x {Beta}({Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +}). Furthermore, we observe an enhancement at the threshold of the invariant mass of the baryon-antibaryon pair.

  16. High-speed readout of high-Z pixel detectors with the LAMBDA detector

    NASA Astrophysics Data System (ADS)

    Pennicard, D.; Smoljanin, S.; Sheviakov, I.; Xia, Q.; Rothkirch, A.; Yu, Y.; Struth, B.; Hirsemann, H.; Graafsma, H.

    2014-12-01

    High-frame-rate X-ray pixel detectors make it possible to perform time-resolved experiments at synchrotron beamlines, and to make better use of these sources by shortening experiment times. LAMBDA is a photon-counting hybrid pixel detector based on the Medipix3 chip, designed to combine a small pixel size of 55 μm, a large tileable module design, high speed, and compatibility with ``high-Z'' sensors for hard X-ray detection. This technical paper focuses on LAMBDA's high-speed-readout functionality, which allows a frame rate of 2000 frames per second with no deadtime between successive images. This takes advantage of the Medipix3 chip's ``continuous read-write'' function and highly parallelised readout. The readout electronics serialise this data and send it back to a server PC over two 10 Gigabit Ethernet links. The server PC controls the detector and receives, processes and stores the data using software designed for the Tango control system. As a demonstration of high-speed readout of a high-Z sensor, a GaAs LAMBDA detector was used to make a high-speed X-ray video of a computer fan.

  17. Reinitiation at the lambda DNA origin accompanies the host SOS response

    SciTech Connect

    Schnoes, M.I.; Inman, R.B.

    1987-06-01

    Abnormal reinitiation of replication from lambda origins has previously been found during infection in the presence of caffeine or cis-diamminedichloroplatinum II (cis-Pt) or when lambda infects a P2 lysogen. It was further shown that the reinitiations arising from cis-Pt treatment took place during the SOS response induced by the template damage caused by the drug. It is now shown that SOS induction by uv irradiation of the host also results in reinitiation events and that it is the SOS response itself rather than some other direct effect of the damaged host template that is responsible for the phenomenon. Parental sections of lambda replicative intermediates can supercoil, whereas daughter segments cannot. To explain the control that prevents reinitiation, it is proposed that normally the origin sequence has to be under superhelical tension to be a suitable substrate for the initiating machinery; once a round is in progress, the daughter origin sequences would not be under such tension and would therefore be inactive. It is shown that in an SOS environment the proposed requirement for a superhelical origin sequence is relaxed and consequently the control against reinitiation lost. Under such conditions, primary growing points that have encountered template lesions terminate and a new wave of replication initiates.

  18. Differential cross sections for gamma + p --> K^+ + Y for Lambda and Sigma^0 hyperons

    SciTech Connect

    R. Bradford; R.A. Schumacher; J.W.C. McNabb; L. Todor; et. Al.

    2005-09-29

    High-statistics cross sections for the reactions {gamma} + p {yields} K{sup +} + {Lambda} and {gamma} + p {yields} K{sup +} + {Sigma}{sup 0} have been measured using CLAS at Jefferson Lab for center-of-mass energies W between 1.6 and 2.53 GeV, and for -0.85 < cos {theta}{sub K{sup +}}{sup c.m.} < +0.95. In the K{sup +}{Lambda} channel we confirm a resonance-like structure near W=1.9 GeV at backward kaon angles. The position and width of this structure change with angle, indicating that more than one resonance is likely playing a role. The K{sup +} {Lambda} channel at forward angles and all energies is well described by a t-channel scaling characteristic of Regge exchange, while the same scaling applied to the K{sup +} {Sigma}{sup 0} channel is less successful. Several existing theoretical models are compared to the data, but none provide a good representation of the results.

  19. Measurement of the Branching Fractions of the Decays \\bar{B}^0 to Lambda_c^+ \\bar{p} and B^- to Lambda_c^+ \\bar{p} pi^-

    SciTech Connect

    Aubert, B.; Barate, R.; Bona, M.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Tisserand, V.; Zghiche, A.; Grauges, E.; Palano, A.; Chen, J.C.; Qi, N.D.; Rong, G.; Wang, P.; Zhu, Y.S.; Eigen, G.; Ofte, I.; Stugu, B.; Abrams, G.S.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /INFN, Ferrara /Frascati /Genoa U. /INFN, Genoa /Harvard U. /Heidelberg U. /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Karlsruhe U., EKP /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /Milan U. /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /Naples U. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /Padua U. /INFN, Padua /Pennsylvania U. /Perugia U. /INFN, Perugia /Pisa U. /INFN, Pisa /Prairie View A-M /Princeton U. /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Stony Brook /Tennessee U. /Texas U. /Texas U., Dallas /Turin U. /INFN, Turin /Trieste U. /INFN, Trieste /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison /Yale U.

    2006-12-06

    The authors present studies of two-body and three-body charmed baryonic B decays in a sample of 232 million B{bar B} pairs collected with the BABAR detector at the PEP-II e{sup +}e{sup -} storage ring. The branching fractions of the decays {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar p} and B{sup -} {yields} {Lambda}{sub c}{sup +} {bar p}{pi}{sup -} are measured to be (2.15 {+-} 0.36 {+-} 0.13 {+-} 0.56) x 10{sup -5} and (3.53 {+-} 0.18 {+-} 0.31 {+-} 0.92) x 10{sup -4}, respectively. The uncertainties quoted are statistical, systematic, and from the {Lambda}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +} branching fraction. They observe a baryon-antibaryon threshold enhancement in the {Lambda}{sub c}{sup +}{bar p} invariant mass spectrum of the three-body mode and measure the ratio of the branching fractions to be {Beta}(B{sup -} {yields} {Lambda}{sub c}{sup +}{bar p}{pi}{sup -})/{Beta}({bar B}{sup 0} {yields} {Lambda}{sub c}{sup +}{bar p}) = 16.4 {+-} 2.9 {+-} 1.4. These results are preliminary.

  20. Particle generator

    DOEpatents

    Hess, Wayne P.; Joly, Alan G.; Gerrity, Daniel P.; Beck, Kenneth M.; Sushko, Peter V.; Shlyuger, Alexander L.

    2005-06-28

    Energy tunable solid state sources of neutral particles are described. In a disclosed embodiment, a halogen particle source includes a solid halide sample, a photon source positioned to deliver photons to a surface of the halide, and a collimating means positioned to accept a spatially defined plume of hyperthermal halogen particles emitted from the sample surface.

  1. Utilizing Synthetic Visible Spectra to Explore the Physical Basis for the Classification of Lambda Boötis Stars

    NASA Astrophysics Data System (ADS)

    Cheng, Kwang-Ping; Neff, James E.; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Gray, Richard O.; Corbally, Christopher J.

    2017-01-01

    Since the peculiar nature of Lambda Boötis was first noticed in 1943, the Lambda Boo stars have been recognized as a group of peculiar A-type stars. They are Population I dwarfs that show deficiencies of iron-peak elements (up to 2 dex), but have near-solar C, N, O, and S abundances. In a previous paper, we used both observed and synthetic ultraviolet spectra to demonstrate that the C i 1657 Å/Al ii 1671 Å equivalent width ratio can help distinguish between Lambda Boo stars and other metal-weak stars hotter than 8000 K. In this paper, using observed and synthetic visible (4000-6800 Å) spectra, we demonstrate that the C i 5052.17 Å/Mg ii 4481 Å equivalent width ratio can be used as a quantitative diagnostic for cooler Lambda Boo stars.

  2. Absence of {lambda} immunoglobulin sequences on the supernumerary chromosome of the {open_quotes}cat eye{close_quotes} syndrome

    SciTech Connect

    Hough, C.A.; White, B.N.; Holden, J.J.A.

    1995-09-11

    The supernumerary bisatellited chromosome causing the {open_quotes}cat eye{close_quotes} syndrome (CES) is of chromosome 22 origin and consists of an inverted duplication of the 22pter{r_arrow}22q11.2 region. To determine the extent of involvement of band q11.2 on the bisatellited chromosome, copy number assessment of sequences homologous to cloned {lambda} immunoglobulin ({lambda} Ig) gene region probes was carried out on DNA from individuals with CES using densitometric analysis of Southern blots. None of the 10 {lambda} Ig sequences studied was found in increased copy number in DNA from any of the 10 CES individuals tested, indicating that these sequences are not present on the supernumerary chromosome. The breakpoints involved in the generation of the bisatellited supernumerary chromosome associated with CES are therefore proximal to the {lambda} Ig gene region. 20 refs., 1 fig., 3 tabs.

  3. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.

    PubMed

    Vela, José Luis; Aït-Azzouzene, Djemel; Duong, Bao Hoa; Ota, Takayuki; Nemazee, David

    2008-02-01

    The recombining sequence (RS) of mouse and its human equivalent, the immunoglobulin (Ig) kappa deleting element (IGKDE), are sequences found at the 3' end of the Ig kappa locus (Igk) that rearrange to inactivate Igk in developing B cells. RS recombination correlates with Ig lambda (Iglambda) light (L) chain expression and likely plays a role in receptor editing by eliminating Igk genes encoding autoantibodies. A mouse strain was generated in which the recombination signal of RS was removed, blocking RS-mediated Igk inactivation. In RS mutant mice, receptor editing and self-tolerance were impaired, in some cases leading to autoantibody formation. Surprisingly, mutant mice also made fewer B cells expressing lambda chain, whereas lambda versus kappa isotype exclusion was only modestly affected. These results provide insight into the mechanism of L chain isotype exclusion and indicate that RS has a physiological role in promoting the formation of lambda L chain-expressing B cells.

  4. On the theoretical link between LLL-reduction and Lambda-decorrelation

    NASA Astrophysics Data System (ADS)

    Lannes, A.

    2013-04-01

    The LLL algorithm, introduced by Lenstra et al. (Math Ann 261:515-534, 1982), plays a key role in many fields of applied mathematics. In particular, it is used as an effective numerical tool for preconditioning the integer least-squares problems arising in high-precision geodetic positioning and Global Navigation Satellite Systems (GNSS). In 1992, Teunissen developed a method for solving these nearest-lattice point (NLP) problems. This method is referred to as Lambda (for Least-squares AMBiguity Decorrelation Adjustment). The preconditioning stage of Lambda corresponds to its decorrelation algorithm. From an epistemological point of view, the latter was devised through an innovative statistical approach completely independent of the LLL algorithm. Recent papers pointed out some similarities between the LLL algorithm and the Lambda-decorrelation algorithm. We try to clarify this point in the paper. We first introduce a parameter measuring the orthogonality defect of the integer basis in which the NLP problem is solved, the LLL-reduced basis of the LLL algorithm, or the Λ -basis of the Lambda method. With regard to this problem, the potential qualities of these bases can then be compared. The Λ -basis is built by working at the level of the variance-covariance matrix of the float solution, while the LLL-reduced basis is built by working at the level of its inverse. As a general rule, the orthogonality defect of the Λ -basis is greater than that of the corresponding LLL-reduced basis; these bases are however very close to one another. To specify this tight relationship, we present a method that provides the dual LLL-reduced basis of a given Λ -basis. As a consequence of this basic link, all the recent developments made on the LLL algorithm can be applied to the Lambda-decorrelation algorithm. This point is illustrated in a concrete manner: we present a parallel Λ -type decorrelation algorithm derived from the parallel LLL algorithm of Luo and Qiao (Proceedings of

  5. NE VIII lambda 774 and time variable associated absorption in the QSO UM 675

    NASA Astrophysics Data System (ADS)

    Hamann, Fred; Barlow, Thomas A.; Beaver, E. A.; Burbidge, E. M.; Cohen, Ross D.; Junkkarinen, Vesa; Lyons, R.

    1995-04-01

    We discuss measurements of Ne VIII lambda 774 absorption and the time variability of other lines in the za approximately equal ze absorption system of the ze = 2.15 QSO UM 675 (0150-203). The C IV lambda 1549 and N V 1240 doublets at za = 2.1340 (shifted approximately 1500 km/s from ze strengthened by a factor of approximately 3 between observations by Sargent, Boksenberg and Steidel (1981 November) and our earliest measurements (1990 November and December). We have no information on changes in other za approximately equal ze absorption lines. Continued monitoring since 1990 November shows no clear changes in any of the absorptions between approximately 1100 and 1640 A rest. The short timescale of the variability (less than or approximately equal to 2.9 yr rest) strongly suggests that the clouds are dense, compact, close to the QSO, and photoionized by the QSO continuum. If the line variability is caused by changes in the ionization, the timescale requires densities greater than approximately 4000/cu cm. Photoionization calculations place the absorbing clouds within approximately 200 pc of the continuum source. The full range of line ionizations (from Ne VIII lambda 774 to C III lambda 977) in optically thin gas (no Lyman limit) implies that the absorbing regions span a factor of more than approximately 10 in distance or approximately 100 in density. Across these regions, the total hydrogen (H I + H II) column ranges from a few times 1018/sq cm in the low-ionization gas to approximately 1020/sq cm where the Ne VIII doublet forms. The metallicity is roughly solar or higher, with nitrogen possibly more enhanced by factors of a few. The clouds might contribute significant line emission if they nearly envelop the QSO. The presence of highly ionized Ne VIII lambda 774 absorption near the QSO supports recent studies that link za approximately equal to ze systems with X-ray 'wamr absorbers. We show that the Ne VIII absorbing gas would itself produce measurable warm

  6. NE VIII lambda 774 and time variable associated absorption in the QSO UM 675

    NASA Technical Reports Server (NTRS)

    Hamann, Fred; Barlow, Thomas A.; Beaver, E. A.; Burbidge, E. M.; Cohen, Ross D.; Junkkarinen, Vesa; Lyons, R.

    1995-01-01

    We discuss measurements of Ne VIII lambda 774 absorption and the time variability of other lines in the z(sub a) approximately equal z(sub e) absorption system of the z(sub e) = 2.15 QSO UM 675 (0150-203). The C IV lambda 1549 and N V 1240 doublets at z(sub a) = 2.1340 (shifted approximately 1500 km/s from z(sub e) strengthened by a factor of approximately 3 between observations by Sargent, Boksenberg and Steidel (1981 November) and our earliest measurements (1990 November and December). We have no information on changes in other z(sub a) approximately equal z(sub e) absorption lines. Continued monitoring since 1990 November shows no clear changes in any of the absorptions between approximately 1100 and 1640 A rest. The short timescale of the variability (less than or approximately equal to 2.9 yr rest) strongly suggests that the clouds are dense, compact, close to the QSO, and photoionized by the QSO continuum. If the line variability is caused by changes in the ionization, the timescale requires densities greater than approximately 4000/cu cm. Photoionization calculations place the absorbing clouds within approximately 200 pc of the continuum source. The full range of line ionizations (from Ne VIII lambda 774 to C III lambda 977) in optically thin gas (no Lyman limit) implies that the absorbing regions span a factor of more than approximately 10 in distance or approximately 100 in density. Across these regions, the total hydrogen (H I + H II) column ranges from a few times 10(exp 18)/sq cm in the low-ionization gas to approximately 10(exp 20)/sq cm where the Ne VIII doublet forms. The metallicity is roughly solar or higher, with nitrogen possibly more enhanced by factors of a few. The clouds might contribute significant line emission if they nearly envelop the QSO. The presence of highly ionized Ne VIII lambda 774 absorption near the QSO supports recent studies that link z(sub a) approximately equal to z(sub e) systems with X-ray 'wamr absorbers. We show that the

  7. Quantitative Analysis of the Stability of Lysogenic State in Phage lambda

    NASA Astrophysics Data System (ADS)

    Ao, Ping

    2004-03-01

    Based on the recently developed dynamical structure theory for complex networks and the seminal work of Shea and Ackers in the 1980's, we formulate a transparent and concise mathematical framework for the gene regulatory network controlling phage lambda life cycles, which naturally includes the stochastic effect. The dynamical structure theory states that the dynamics of a complex network is determined by its four elementary components: The dissipation (analogous to degradation) and stochastic force, the driving force determined by a potential and the transverse force. The potential may be interpreted as a landscape for the phage development in terms of attractive basins, saddle points, peaks and valleys. The dissipation gives rise to the adaptivity of the phage in the landscape defined by the potential: The phage always has the tendency to approach the bottom of the nearby attractive basin. The stochastic fluctuation gives the phage the ability to search around the potential landscape by passing through saddle points. With molecular parameters in our model fixed primarily by the experimental data on wild type phage and supplemented by data on one mutant, our calculated results on mutants agree quantitatively with the available experimental observations on other mutants for protein number, lysogenization frequency, lysis frequency in lysogen culture. The calculation reproduces the observed robustness of the phage lambda genetic switch. This is the first mathematical description which successfully represents such a wide variety of major experimental phenomena. Specifically we find: 1) The explanation for both the stability and the efficiency of phage lambda switch is the exponential dependence of saddle point crossing rate on potential barrier height, a result of the stochastic motion in a landscape; 2) The positive feedback of CI transcription, enhanced by the CI dimer cooperative binding, is the key to the robustness of the phage lambda genetic switch against

  8. Narrow structure in {Lambda}d scattering near the {Sigma} threshold ({sub {Sigma}}{sup 3}He states)

    SciTech Connect

    Gibson, B.F.; Afnan, I.R.

    1991-12-31

    A separable-potential, Faddeev-type calculation of {Lambda}-deuteron scattering near the threshold for {Sigma} production is shown to produce structure (a resonance peak) in the cross section which lies below the {Sigma} threshold for two different YN ({Lambda}N-{Sigma}N coupled-channel) potential models. In one case the {Sigma}NN eigenvalue corresponds to a pole which lies below threshold (bound) and in the second case the poles lies above the threshold.

  9. Rearrangement and expression of the human {Psi}C{lambda}6 gene segment results in a surface Ig receptor with a truncated light chain constant region

    SciTech Connect

    Stiernholm, N.B.J.; Verkoczy, L.K.; Berinstein, N.L.

    1995-05-01

    The constant region of the human Ig{lambda} locus consists of seven tandemly organized J-C gene segments. Although it has been established that the J-C{lambda}1, J-C{lambda}2, J-C{lambda}3, and J-C{lambda}7 gene segments are functional, and code for the four distinct Ig{lambda} isotypes found in human serum, the J-C{lambda}4, J-C{lambda}5, and J-C{lambda}6 gene segments are generally considered to be pseudogenes. Although one example of a functional J-C{lambda}6 gene segment has been documented, in the majority of cases, J-C{lambda}6 is rendered nonfunctional by virtue of a single duplication of four nucleotides, creating a premature translational arrest. We show here that rearrangements to the J-C{lambda}6 gene segment do occur, and that such a rearrangement encodes an Ig{lambda} protein that lacks the terminal end of the constant region. We also show that this truncated protein is expressed on the surface with the IgH chain, creating an unusual surface Ig (sIg) receptor (sIg{triangle}CL). Cells that express this receptor on the surface do so at significantly reduced levels compared with clonally related variants, which express sIg receptors with conventional Ig{lambda} L chains. However, the effects of sIg cross-linking on tyrosine phosphorylation and surface expression of the CD25 and CD71 Ags are similar in cells that express conventional sIg receptors and in those that express sIg{triangle}CL receptors, suggesting that the latter could possibly function as an Ag receptor. 35 refs., 7 figs.

  10. Science Archives in the 21st Century: A NASA LAMBDA Report

    NASA Technical Reports Server (NTRS)

    Butterworth, P.; Greason, M.

    2007-01-01

    Lambda is a thematic data center that focuses on serving the cosmic microwave background (CMB) research community. LAMBDA is an active archive for NASA's Cosmic Background Explorer (COBE) and Wilkinson Microwave Anisotropy Probe (WMAP) mission data sets. In addition, LAMBDA provides analysis software, on-line tools, relevant ancillary data and important web links. LAMBDA also tries to preserve the most important ground-based and suborbital CMB data sets. CMB data is unlike other astrophysical data, consisting of intrinsically diffuse surface brightness photometry with a signal contrast of the order 1 part in 100,000 relative to the uniform background. Because of the extremely faint signal levels, the signal-to-noise ratio is relatively low and detailed instrument-specific knowledge of the data is essential. While the number of data sets being produced is not especially large, those data sets are becoming large and complex. That tendency will increase when the many polarization experiments currently being deployed begin producing data. The LAMBDA experience supports many aspects of the NASA data archive model developed informally over the last ten years-that small focused data centers are often more effective than larger more ambitious collections, for example; that data centers are usually best run by active scientists; that it can be particularly advantageous if those scientists are leaders in the use of the archived data sets; etc. LAMBDA has done some things so well that they might provide lessons for other archives. A lot of effort has been devoted to developing a simple and consistent interface to data sets, for example; and serving all the documentation required via simple 'more' pages and longer explanatory supplements. Many of the problems faced by LAMBDA will also not surprise anyone trying to manage other space science data. These range from persuading mission scientists to provide their data as quickly as possible, to dealing with a high volume of

  11. Science Archives in the 21st Century: A NASA LAMBDA Report

    NASA Technical Reports Server (NTRS)

    Butterworth, P.; Greason, M.

    2007-01-01

    Lambda is a thematic data center that focuses on serving the cosmic microwave background (CMB) research community. LAMBDA is an active archive for NASA's Cosmic Background Explorer (COBE) and Wilkinson Microwave Anisotropy Probe (WMAP) mission data sets. In addition, LAMBDA provides analysis software, on-line tools, relevant ancillary data and important web links. LAMBDA also tries to preserve the most important ground-based and suborbital CMB data sets. CMB data is unlike other astrophysical data, consisting of intrinsically diffuse surface brightness photometry with a signal contrast of the order 1 part in 100,000 relative to the uniform background. Because of the extremely faint signal levels, the signal-to-noise ratio is relatively low and detailed instrument-specific knowledge of the data is essential. While the number of data sets being produced is not especially large, those data sets are becoming large and complex. That tendency will increase when the many polarization experiments currently being deployed begin producing data. The LAMBDA experience supports many aspects of the NASA data archive model developed informally over the last ten years-that small focused data centers are often more effective than larger more ambitious collections, for example; that data centers are usually best run by active scientists; that it can be particularly advantageous if those scientists are leaders in the use of the archived data sets; etc. LAMBDA has done some things so well that they might provide lessons for other archives. A lot of effort has been devoted to developing a simple and consistent interface to data sets, for example; and serving all the documentation required via simple 'more' pages and longer explanatory supplements. Many of the problems faced by LAMBDA will also not surprise anyone trying to manage other space science data. These range from persuading mission scientists to provide their data as quickly as possible, to dealing with a high volume of

  12. The criteria weight determination of factors impacting the melt flow index of degradable plastics using Lambda-Max method

    NASA Astrophysics Data System (ADS)

    Dom, Rosma Mohd; Saadon, Nurul Adzlyana; Mohamad, Daud

    2013-09-01

    Three common methods of determining criteria weights using the Analytic Hierarchy Process (AHP) are extent analysis, logarithmic least square method (LLSM) and Lambda-Max. Lambda-Max criteria weights determination method uses pair wise comparison of criteria considered. Studies have shown that Lambda-Max is a preferred criteria weight determination method since it involves lesser computation with consistent results of precise criteria weights generated. In this paper the criteria weights of four factors impacting the Melt Flow Index of degradable plastics are calculated using Lambda-Max method. The input factors (criteria) are the percentages by mass of polyethylene, oil palm biomass, palm olein and starch used in the formulation of degradable plastics. The criteria weights are calculated using Lambda-Max based on input given by four experts. The finding indicates the feasibility of using Lambda-Max method in criteria weight determination for determining the impact of four factors in the formulation of degradable plastics as reflected by the consistency control index value calculated.

  13. Coupling of Charged Particles Via Coulombic Interactions: Numerical Simulations and Resultant Kappa-Like Velocity Space Distribution Functions

    NASA Technical Reports Server (NTRS)

    Randol, Brent M.; Christian, Eric R.

    2016-01-01

    A parametric study is performed using the electrostatic simulations of Randol and Christian (2014) in which the number density, n, and initial thermal speed, theta, are varied. The range of parameters covers an extremely broad plasma regime, all the way from the very weak coupling of space plasmas to the very strong coupling of solid plasmas. The first result is that simulations at the same Lambda(sub D), where Lambda(sub D) is the plasma coupling parameter, but at different combinations of n and theta, behave exactly the same. As a function of Lambda(sub D), the form of p(v), the velocity distribution function of v, the magnitude of v, the velocity vector, is studied. For intermediate to high D, heating is observed in p(v) that obeys conservation of energy, and a suprathermal tail is formed, with a spectral index that depends on Lambda(sub D). For strong coupling (Lambda(sub D) much > 1), the form of the tail is v5, consistent with the findings of Randol and Christian (2014). For weak coupling (Lambda(sub D much <1), no acceleration or heating occurs, as there is no free energy. The dependence on N, the number of particles in the simulation, is also explored. There is a subtle dependence in the index of the tail, such that v5 appears to be the N approaches infinity limit.

  14. Stochastic transport of interacting particles in periodically driven ratchets.

    PubMed

    Savel'ev, Sergey; Marchesoni, Fabio; Nori, Franco

    2004-12-01

    An open system of overdamped, interacting Brownian particles diffusing on a periodic substrate potential U(x+l)=U(x) is studied in terms of an infinite set of coupled partial differential equations describing the time evolution of the relevant many-particle distribution functions. In the mean-field approximation, this hierarchy of equations can be replaced by a nonlinear integro-differential Fokker-Planck equation. This is applicable when the distance a between particles is much less than the interaction length lambda , i.e., a particle interacts with many others, resulting in averaging out fluctuations. The equation obtained in the mean-field approximation is applied to an ensemble of locally (a<lambdaparticles placed in an asymmetric one-dimensional substrate potential, either with an oscillating temperature (temperature rachet) or driven by an ac force (rocked ratchet). In both cases we focus on the high-frequency limit. For the temperature ratchet, we find that the net current is typically suppressed (or can even be inverted) with increasing density of the repelling particles. In contrast, the net current through a rocked ratchet can be enhanced by increasing the density of the repelling particles. In the case of attracting particles, our perturbation technique is valid up to a critical value of the particle density, above which a finite fraction of the particles starts condensing in a liquidlike state near the substrate minima. The dependence of the net transport current on the particle density and the interparticle potential is analyzed in detail for different values of the ratchet parameters.

  15. Dynamics of Single Chains of Suspended Ferrofluid Particles

    NASA Technical Reports Server (NTRS)

    Cutillas, S.; Liu, J.

    1999-01-01

    We present an experimental study of the dynamics of isolated chains made of super-paramagnetic particles under the influence of a magnetic field. The motivation of this work is to understand if the chain fluctuations exist and, if it does, how does the fluctuation affect chain aggregation. We find that single chains strongly fluctuate and that the characteristic frequency of their fluctuations is inversely proportional to the magnetic field strength. The higher the field the lower the characteristic frequency of the chain fluctuations. In the high magnetic field limit, chains behave like rigid rods without any internal motions. In this work, we used ferrofluid particles suspended in water. These particles do not have any intrinsic magnetization. Once a magnetic field is applied, a dipole moment is induced in each particle, proportional to the magnetic field. A dipolar magnetic interaction then occurs between particles. If dipole-dipole magnetic energy is higher than the thermal energy, the result is a structure change inside the dipolar fluid. The ratio of these two energies is expressed by a coupling constant lambda as: lambda = (pi(a(exp 3))(chi(exp 2))(mu(sub 0))(H(sub 0))(exp 2))/18kT Where a is the particle radius, mu(sub 0) is the vacuum magnetic permeability, H(sub 0) the applied magnetic field, k the Boltzmann constant and T the absolute temperature. If lambda > 1, magnetic particles form chains along the field direction. The lateral coalescence of several chains may form bigger aggregates especially if the particle volume fraction is high. While many studies and applications deal with the rheological properties and the structural changes of these dipolar fluids, this work focuses on the understanding of the chain dynamics. In order to probe the chain dynamics, we used dynamic light scattering (DLS) in self-beating mode as our experimental technique. The experimental geometry is such that the scattering plane is perpendicular to the magnetic field

  16. Particle therapy

    SciTech Connect

    Raju, M.R.

    1993-09-01

    Particle therapy has a long history. The experimentation with particles for their therapeutic application got started soon after they were produced in the laboratory. Physicists played a major role in proposing the potential applications in radiotherapy as well as in the development of particle therapy. A brief review of the current status of particle radiotherapy with some historical perspective is presented and specific contributions made by physicists will be pointed out wherever appropriate. The rationale of using particles in cancer treatment is to reduce the treatment volume to the target volume by using precise dose distributions in three dimensions by using particles such as protons and to improve the differential effects on tumors compared to normal tissues by using high-LET radiations such as neutrons. Pions and heavy ions combine the above two characteristics.

  17. Particle separator

    DOEpatents

    Hendricks, Charles D.

    1990-01-01

    Method and apparatus (10) are provided for separating and classifying particles (48,50,56) by dispersing the particles within a fluid (52) that is upwardly flowing within a cone-shaped pipe (12) that has its large end (20) above its small end (18). Particles of similar size and shape (48,50) migrate to individual levels (A,B) within the flowing fluid. As the fluid is deflected by a plate (42) at the top end of the pipe (12), the smallest particles are collected on a shelf-like flange (40). Ever larger particles are collected as the flow rate of the fluid is increased. To prevent particle sticking on the walls (14) of the pipe (12), additional fluid is caused to flow into the pipe (12) through holes (68) that are specifically provided for that purpose. Sticking is further prevented by high frequency vibrators (70) that are positioned on the apparatus (10).

  18. Particle astrophysics

    NASA Technical Reports Server (NTRS)

    Sadoulet, Bernard; Cronin, James; Aprile, Elena; Barish, Barry C.; Beier, Eugene W.; Brandenberger, Robert; Cabrera, Blas; Caldwell, David; Cassiday, George; Cline, David B.

    1991-01-01

    The following scientific areas are reviewed: (1) cosmology and particle physics (particle physics and the early universe, dark matter, and other relics); (2) stellar physics and particles (solar neutrinos, supernovae, and unconventional particle physics); (3) high energy gamma ray and neutrino astronomy; (4) cosmic rays (space and ground observations). Highest scientific priorities for the next decade include implementation of the current program, new initiatives, and longer-term programs. Essential technological developments, such as cryogenic detectors of particles, new solar neutrino techniques, and new extensive air shower detectors, are discussed. Also a certain number of institutional issues (the funding of particle astrophysics, recommended funding mechanisms, recommended facilities, international collaborations, and education and technology) which will become critical in the coming decade are presented.

  19. Particle astrophysics

    NASA Astrophysics Data System (ADS)

    Sadoulet, Bernard; Cronin, James; Aprile, Elena; Barish, Barry C.; Beier, Eugene W.; Brandenberger, Robert; Cabrera, Blas; Caldwell, David; Cassiday, George; Cline, David B.

    The following scientific areas are reviewed: (1) cosmology and particle physics (particle physics and the early universe, dark matter, and other relics); (2) stellar physics and particles (solar neutrinos, supernovae, and unconventional particle physics); (3) high energy gamma ray and neutrino astronomy; (4) cosmic rays (space and ground observations). Highest scientific priorities for the next decade include implementation of the current program, new initiatives, and longer-term programs. Essential technological developments, such as cryogenic detectors of particles, new solar neutrino techniques, and new extensive air shower detectors, are discussed. Also a certain number of institutional issues (the funding of particle astrophysics, recommended funding mechanisms, recommended facilities, international collaborations, and education and technology) which will become critical in the coming decade are presented.

  20. Magnetic particles

    NASA Technical Reports Server (NTRS)

    Chang, Manchium (Inventor); Colvin, Michael S. (Inventor)

    1989-01-01

    Magnetic polymer particles are formed by swelling porous, polymer particles and impregnating the particles with an aqueous solution of precursor magnetic metal salt such as an equimolar mixture of ferrous chloride and ferric chloride. On addition of a basic reagent such as dilute sodium hydroxide, the metal salts are converted to crystals of magnetite which are uniformly contained througout the pores of the polymer particle. The magnetite content can be increased and neutral buoyancy achieved by repetition of the impregnaton and neutralization steps to adjust the magnetite content to a desired level.

  1. The effect of confinement on liquid helium near the lambda line

    SciTech Connect

    Larson, M.E.

    1993-12-31

    This thesis is the compilation of several projects relevant to the behavior of confined liquid helium near the {lambda}-line. The first project described is the development of two new high resolution thermometers optimized for specific heat studies of helium confined in pores. One of the thermometers is a superconductive transition thermometer (STT). The STT has a temperature resolution of about 5nK. The other high resolution thermometer described is a magnetic susceptibility thermometer. This thermometer measures the magnetization of copper ammonium bromide (CAB) using a SQUID magnetometer. The CAB thermometer has an observed sensitivity of about 20nK. Suggestions for improvements in both thermometers are made. Simulation work on the temperature profile of a thermal conductivity cell near T{lambda} is described. The simulations are compared with the experimental results, and a careful study of the stability of the numerics is described. The study of helium confined into pores and films is described next. Both previous theoretical and experimental work on finite size effects in liquid helium are described. The geometry provided by glass capillary arrays is analyzed to determine what would be observed when the specific heat of helium confined to the arrays is measured. Finally, I describe my measurements of the isobaric thermal expansion coefficient {beta}{sub P} of 4He confined in an aerogel for several isobars along the {lambda}-line. {beta}{sub P} is an asymptotically linear function of C{sub P} near the superfluid transition temperature {Tc}. Therefore, fits to power laws in t {triple_bond} T/{Tc} - 1 give the specific heat exponents {alpha} and {alpha}{prime} and amplitude ratio A{prime}/A. Such fits gave different exponents {alpha} {approx} -0.6 and {alpha}{prime} {approx} -1.0 above and below {Tc}.

  2. Posttranscriptional control of bacteriophage lambda gene expression from a site distal to the gene.

    PubMed Central

    Guarneros, G; Montañez, C; Hernandez, T; Court, D

    1982-01-01

    The bacteriophage lambda int gene product, integrase, recombines the phage DNA with the host DNA at specific sites on each to accomplish lysogeny. The int gene is transcribed from two promoters, PL and PI, each regulated positively by lambda proteins. The expression of integrase is also controlled from a site, sib, in the b region of the phage genome. This is a unique regulatory site because it is located distal to the structural gene in relation to the promoters. The expression of int from the PL promoter is inhibited when sib is present. This effect appears to be specific for PL because sib does not cause inhibition of PI-dependent int synthesis. lambda mutants that contain alterations in the site have been isolated. Sequence analyses of the mutations reveal single base changes, spanning 37 base pairs (bp) in the b region, some 240 bp beyond the int gene. Another mutant, hef13, which has a phenotype similar to that of sib, introduces a nucleotide change within the same 37-bp region. The sib and hef mutations cluster within a region of dyad symmetry. Regulation of int synthesis by sib occurs after transcription of the int gene. There is no difference in the rate of PL-promoted int mRNA synthesis in either sib+ or sib- phage infections, yet int mRNA is less stable in the sib+ infection. Because RNase III host mutants are defective in sib regulation, processing of the PL mRNA at sib by this endoribonuclease may cause int mRNA decay and decrease int synthesis. PMID:6281759

  3. Synthesis of two-dimensional human walking: a test of the lambda-model.

    PubMed

    Günther, Michael; Ruder, Hanns

    2003-08-01

    To test the lambda-model version of the equilibrium point hypothesis both for feasibility and validity with respect to the control of terrestrial locomotion, we developed a two-dimensional, eleven-segment musculoskeletal model of the human body including 14 muscle-tendon complexes per leg, three-segment feet, and a physiologically based model of foot-ground interaction. Human walking was synthesized by numerical integration of the coupled muscle-tendon and rigid body dynamics. To this end a control algorithm based on the lambda-model was implemented in the model providing muscle stimulation patterns that guaranteed dynamically stable walking including a balanced trunk. Thus, the timing of the movement is not preset by a central pattern generator but emerges from the interaction of the musculoskeletal system with the control algorithm. The control parameters were found in a trial-and-error approach. The feedforward part of the control scheme consists of just two target configurations each of which is composed of a set of one nominal length per muscle (lambda-model). Variation of gravity reveals that (1) the synthesized walking patterns are close to ballistic walking and (2) this muscularly induced natural walking can only be initiated and maintained in the range between about a tenth and three times earth-bound gravity. Our walking patterns are robust both against parameter variations and shuffling of the swing leg. We discuss our model with respect to gravity scaling, speed control, feedback delay, and the terms "equilibrium point hypothesis" and "central pattern generator."

  4. Is it possible to observationally distinguish adiabatic quartessence from {lambda}CDM?

    SciTech Connect

    Amendola, L.; Reis, R. R. R.; Waga, I.

    2006-09-15

    The equation of state (EOS) in quartessence models interpolates between two stages: p{approx_equal}0 at high energy densities and p{approx_equal}-{rho} at small ones. In the quartessence models analyzed up to now, the EOS is convex, implying increasing adiabatic sound speed (c{sub s}{sup 2}) as the energy density decreases in an expanding universe. A nonnegligible c{sub s}{sup 2} at recent times is the source of the matter power spectrum problem that plagued all convex (nonsilent) quartessence models. Viability for these cosmologies is only possible in the limit of almost perfect mimicry to {lambda}CDM. In this work we investigate if similarity to {lambda}CDM is also required in the class of quartessence models whose EOS changes concavity as the Universe evolves. We focus our analysis in the simple case in which the EOS has a steplike shape, such that at very early times p{approx_equal}0, and at late times p{approx_equal}const<0. For this class of models a nonnegligible c{sub s}{sup 2} is a transient phenomenon and could be relevant only at a more early epoch. We show that agreement with a large set of cosmological data requires that the transition between these two asymptotic states would have occurred at high redshift (z{sub t} > or approx. 38). This leads us to conjecture that the cosmic expansion history of any successful nonsilent quartessence is (practically) identical to the {lambda}CDM one.

  5. The pharmacokinetics of peginterferon lambda-1a following single dose administration to subjects with impaired renal function

    PubMed Central

    Hruska, Matthew W; Adamczyk, Robert; Colston, Elizabeth; Hesney, Michael; Stonier, Michele; Myler, Heather; Bertz, Richard

    2015-01-01

    Aims This open label study was conducted to assess the effect of renal impairment (RI) on the pharmacokinetics (PK) of peginterferon lambda-1a (Lambda). Methods Subjects (age 18–75 years, BMI 18–35 kg m–2) were enrolled into one of five renal function groups: normal (n = 12), mild RI (n = 8), moderate RI (n = 8), severe RI (n = 7), end-stage renal disease (ESRD, n = 8) based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation. Subjects received a single dose of Lambda (180 µg) subcutaneously on day 1 followed by PK serum sample collections through day 29. Safety, tolerability and immunogenicity data were collected through day 43. PK parameters were estimated and summarized by group. Geometric mean ratios (GMR) and 90% confidence intervals (CIs) were calculated between normal and RI groups. Results With decreasing eGFR, Lambda exposure (Cmax, AUC) increased while apparent clearance (CL/F) and apparent volume of distribution (V/F) decreased. Relative to subjects with normal renal function (geometric mean AUC = 99.5 ng ml–1 h), Lambda exposure estimates (AUC) were slightly increased in the mild RI group (geometric mean [90% CI]: 1.20 [0.82, 1.77]) and greater in the moderate (1.95 [1.35, 2.83]), severe RI (1.95 [1.30, 2.93]) and ESRD (1.88 [1.30, 2.73]) groups. Lambda was generally well tolerated. Conclusions The results demonstrated that RI reduces the clearance of Lambda and suggests that dose modifications may not be required in patients with mild RI but may be required in patients with moderate to severe RI or ESRD. PMID:25807956

  6. PWA prospects for K+Lambda and K+Sigma^0 photoproduction

    SciTech Connect

    Biplab Dey, Michael E. McCracken, Curtis A. Meyer

    2012-04-01

    We present a status update on the CMU group PWA efforts in the strangeness (K{sup +}{Lambda}/K{sup +}{Sigma}{sup 0}) sector. The bulk of the currently available data comes from recently published CLAS g11a results, with extensive polarization data expected soon from the CLAS g8 and g9 set of experiments. We give a brief description of issues pertaining to different sign conventions for the polarization observables in the literature, and normalization discrepancies between the CLAS-g11a results and older high energy data from SLAC/CEA/DESY that used an untagged photon beam.

  7. Refractive index measured by laser beam displacement at {lambda}=1064 nm for solvents and deuterated solvents

    SciTech Connect

    Shelton, David P.

    2011-07-20

    The refractive index of a liquid is determined with 0.0003 accuracy from measurements of laser beam displacement by a liquid-filled standard 10 mm spectrophotometer cell. The apparatus and methods are described and the results of measurements at {lambda}=1064 nm and T=25.0 deg. C for 30 solvents and deuterated solvents are presented. Several sources of potential systematic errors as large as 0.003 are identified, the most important being the curvature of the liquid cell windows. The measurements are analyzed accounting for the significant imperfections of the apparatus.

  8. Detecting non-Abelian geometric phases with three-level {Lambda} systems

    SciTech Connect

    Du Yanxiong; Xue Zhengyuan; Zhang Xinding; Yan Hui

    2011-09-15

    We show that a non-Abelian gauge potential in two nearly degenerated dressed states may be induced by two laser beams interacting with a three-level {Lambda} atomic system. We demonstrate that the populations of the atomic states at the end of a composed path formed by two closed loops are dependent on the order of those two loops, showing an unambiguous signature of the non-Abelian geometric phase. Through numerical calculations, we show that the non-Abelian feature of the geometric phases can be tested under realistic conditions.

  9. Electromagnetic Productions of K{lambda} and K{sigma} on the Nucleons

    SciTech Connect

    Mart, T.

    2008-10-13

    We review the progress and problems in the electromagnetic production of K{lambda} on the nucleon. The problem of the data discrepancy in this channel as well as the corresponding physics consequence are highlighted. We also discuss the effect of the new beam-recoil polarization data C{sub x} and C{sub z} on our analysis. For this purpose we use the isobar model Kaon-Maid and a recent multipoles model that can describe recent experimental data. We also present a new multipoles model for the K{sigma} channels to complete our analysis.

  10. Prediction of Narrow N* and {Lambda}* Resonances with Hidden Charm above 4 GeV

    SciTech Connect

    Wu Jiajun; Molina, R.; Oset, E.; Zou, B. S.

    2010-12-03

    The interaction between various charmed mesons and charmed baryons is studied within the framework of the coupled-channel unitary approach with the local hidden gauge formalism. Several meson-baryon dynamically generated narrow N{sup *} and {Lambda}{sup *} resonances with hidden charm are predicted with mass above 4 GeV and width smaller than 100 MeV. The predicted new resonances definitely cannot be accommodated by quark models with three constituent quarks and can be looked for in the forthcoming PANDA/FAIR experiments.

  11. Additional atmospheric opacity measurements at lambda = 1.1 mm from Mauna Kea Observatory, Hawaii

    NASA Technical Reports Server (NTRS)

    Parrish, A.; De Zafra, R. L.; Barrett, J. W.; Solomon, P.; Connor, B.

    1987-01-01

    Atmospheric opacity values in the zenith direction are given for a wavelength of 1.1 mm (278 GHz) at the summit of Mauna Kea in the Hawaiian Islands. A total of 75 days is covered during the period 1983-1986. Observations were made on a quasi-continuous basis, with opacity measured every 20 minutes around the clock for significant periods of time. A conversion from opacity at lambda = 1.1 mm to the equivalent precipitable water vapor column is given from the measurements of Zammit and Ade (1981), from which opacities at other wavelengths may be derived.

  12. The global lambda visualization facility: An international ultra-high-definition wide-area visualization collaboratory

    USGS Publications Warehouse

    Leigh, J.; Renambot, L.; Johnson, Aaron H.; Jeong, B.; Jagodic, R.; Schwarz, N.; Svistula, D.; Singh, R.; Aguilera, J.; Wang, X.; Vishwanath, V.; Lopez, B.; Sandin, D.; Peterka, T.; Girado, J.; Kooima, R.; Ge, J.; Long, L.; Verlo, A.; DeFanti, T.A.; Brown, M.; Cox, D.; Patterson, R.; Dorn, P.; Wefel, P.; Levy, S.; Talandis, J.; Reitzer, J.; Prudhomme, T.; Coffin, T.; Davis, B.; Wielinga, P.; Stolk, B.; Bum, Koo G.; Kim, J.; Han, S.; Corrie, B.; Zimmerman, T.; Boulanger, P.; Garcia, M.

    2006-01-01

    The research outlined in this paper marks an initial global cooperative effort between visualization and collaboration researchers to build a persistent virtual visualization facility linked by ultra-high-speed optical networks. The goal is to enable the comprehensive and synergistic research and development of the necessary hardware, software and interaction techniques to realize the next generation of end-user tools for scientists to collaborate on the global Lambda Grid. This paper outlines some of the visualization research projects that were demonstrated at the iGrid 2005 workshop in San Diego, California.

  13. X-ray and electron generation in the relativistic lambda-cubed regime

    NASA Astrophysics Data System (ADS)

    Mordovanakis, Aghapi G.

    Over the last two decades, laser-plasma interactions at relativistic intensities have been carried out using large laser facilities producing at least several hundred millijoule pulses at a repetition rate of 10 Hz or lower. A less explored regime is when intensities in excess of 1018 W/cm2 are attained by focusing millijoule-level femtosecond pulses to a spot with a diameter comparable to the laser wavelength. This so-called relativistic lambda3 regime allows the study of certain laser-plasma experiments at kilohertz repetition rate. The present dissertation contributes to the understanding of the x-ray source and hot electrons produced in this regime. The micron-sized lambda3 focus engenders a comparably sized x-ray source that could be attractive for high resolution x-ray imaging applications. With this in mind, the source size is measured for various target materials using the knife-edge technique. Furthermore, the source spatial coherence properties are investigated by analyzing the diffraction pattern off a straight edge. Also investigated are the spatial and energy distributions of hot electrons escaping the plasma. In the case of an Al plasma, the electrons have a Maxwellian-like energy distribution with a temperature that scales with (I lambda 2)0.6 in the 1017--2 x 10 18 W/cm2 intensity range. On the other hand, in the case of an SiO2 plasma with lambda/2 scale-length, the electrons are emitted in a collimated relativistic jet having a non-Maxwellian distribution with = 675 keV. This is the first demonstration of laser-generated relativistic electron beams at kilohertz repetition rate. Additionally, this dissertation reports on two pioneering demonstrations in a related but fundamentally different regime, that of high-average power fiber lasers. In the first experiment, Ni Kalpha x-rays are produced using a fiber CPA system at the intensity of 2 x 1018 W/cm 2, the highest reported to date from a fiber system. The conversion efficiency into the Kalpha

  14. B, Lambda{sub b} and charm results from the Tevatron

    SciTech Connect

    F. Azfar

    2003-09-18

    Recent results on B{sub d}, B{sub u}{sup {+-}}, B{sub s}, {Lambda}{sub b} and Charm hadrons are reported from {approx} 75 pb{sup -1} and {approx} 40 pb{sup -1} of data accumulated at the upgraded CDF and D0 experiments at the Fermilab Tevatron {bar p}-p collider, during Run-II. These include lifetime and mass measurements of B and Charm hadrons, searches for rare decays in charm and B hadrons and CP-violation in Charm decays. Results relevant to CP-violation in B-decays are also reported.

  15. Systemic lambda light-chain deposition presenting with predominant cardiac involvement.

    PubMed Central

    Garton, M. J.; Walton, S.; Ewen, S. W.

    1993-01-01

    An 82 year old woman with suspected Bence Jones myeloma developed intractable fluid retention presumed secondary to cardiac failure. In addition she experienced angina pectoris, and required permanent cardiac pacing for symptomatic sinus bradycardia. Postmortem studies revealed prominent myocardial and renal deposits of lambda light-chains which were Congo Red negative, and had a non-fibrillar ultrastructure. Non-amyloidotic light-chain deposition is uncommon, and a rare cause of cardiac disease. Previous work regarding possible pathogenetic mechanisms, clinical and laboratory features and treatment is reviewed. Images Figure 1 Figure 2 Figure 3 PMID:8415352

  16. Lambda light chain myeloma presenting as nodular hepatic lesion: a clinical rarity.

    PubMed

    Pal, Santanu; Chattopadhyay, Bitoti; Chatterjee, Atri; Bhattacharya, Biswamit

    2014-01-01

    We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed as hepatic plasmacytoma. Serum and urine immunofixation electrophoresis, serum free light chain ratio, and bone marrow examination further confirmed the presence of lambda light chain multiple myeloma in the background. The patient achieved complete remission after four cycles of induction therapy with thalidomide and dexamethasone protocol and consolidated with further four cycles of the same regimen.

  17. Wolfgang Priester: from the big bounce to the Lambda-dominated universe.

    PubMed

    Overduin, James; Blome, Hans-Joachim; Hoell, Josef

    2007-06-01

    Wolfgang Priester (1924-2005) was one of Germany's most versatile and quixotic astrophysicists, reinventing himself successively as a radio astronomer, space physicist and cosmologist, and making a lasting impact on each field. We focus in this personal account on his contributions to cosmology, where he will be most remembered for his association with quasars, his promotion of the idea of a nonsingular "big bounce" at the beginning of the current expansionary phase, and his recognition of the importance of dark energy (Einstein's cosmological constant Lambda) well before this became the standard paradigm in cosmology.

  18. Subdivision and direction recognition of {lambda}/16 of orthogonal fringes for nanometric measurement

    SciTech Connect

    Hu Haijiang; Qiu Xiaoqian; Wang Jing; Ju Aisong; Zhang Yunbo

    2009-11-20

    Subdivision is one of the essential methods to improve the measurement resolution of optical instruments. A new method is proposed to solve {lambda}/16 bidirectional subdivision and direction recognition for orthogonal interference signals by constructing two sets of reference signals and using zero-cross detection. The experimental results prove that the method is efficient for orthogonal signals and has good real-time performance by field-programmable gate array realization. This method is easy to realize by use of electronic design automation tools and can be widely used in the signal processing system of optical measurement instruments such as a moire fringe measurement system and laser interferometer.

  19. Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis.

    PubMed

    von Keudell, Gottfried; Sanchorawala, Vaishali; O'Hara, Carl; C Seldin, David; Sloan, J Mark

    2014-06-01

    We report on a 58-year-old man who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted plasma cell dyscrasia causing AL amyloidosis involving the kidney and GI tract. While monoclonal immunoglobulins occasionally produced by CLL has previously been implicated in AL amyloidosis, this is the first case of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL. Appropriate treatment depended on detailed pathologic diagnosis of both disease processes.

  20. Plasmonic transmission lines: from micro to nano scale with lambda/4 impedance matching.

    PubMed

    Ginzburg, Pavel; Orenstein, Meir

    2007-05-28

    The downscaling of conventional RF transmission lines methodologies to subwavelength plasmonic circuits is discussed and demonstrated for a lambda/4 transformer impedance matching. The nano-size transformer, matching between 0.5mum and 50nm wide plasmonic transmission lines, enhances the coupling efficiency by more than 285% compared to the direct ("end fire") coupling - i.e. harvesting more than 86% of total incident power. The influence of the transverse resonances induced by the metal claddings of the input transmission line on the light harvesting is discussed as well.

  1. K{Lambda}(1405) configuration of the KK-barN system

    SciTech Connect

    Martinez Torres, A.; Jido, D.

    2010-09-15

    We study the K{Lambda}(1405) configuration of the KK-barN system by considering K{pi}{Sigma} as a coupled channel. We solve the Faddeev equations for these systems and find confirmation of the existence of a new N{sup *} resonance around 1920 MeV, with J{sup {pi}=}1/2{sup +} predicted in a single-channel potential model and also found in a Faddeev calculation as an a{sub 0}(980)N state, with the a{sub 0}(980) generated in the KK-bar, {pi}{eta} interaction.

  2. The interstellar medium near the sun - The line of sight to lambda Scorpii

    NASA Technical Reports Server (NTRS)

    York, D. G.

    1975-01-01

    Copernicus satellite spectrometric observations are used to determine column densities and ionization structure in the local interstellar medium in the line of sight to lambda Sco. Three, or possibly four, regions are identified by physical properties or velocity separations in the UV absorption line profiles, including a region with a temperature near 200,000 K containing O VI lines, one or two H II regions, and an H I region which may also contain S III and C III. Element abundances are tabulated, and abundances in the H I region are shown to have a depletion pattern similar to that for the line of sight to zeta Oph.

  3. {lambda}N{yields}NN weak interaction in effective-field theory

    SciTech Connect

    Parreno, Assumpta; Bennhold, Cornelius; Holstein, Barry R.

    2004-11-01

    The nonleptonic weak |{delta}S|=1 {lambda}N interaction, responsible for the dominant nonmesonic decay of all but the lightest hypernuclei, is studied in the framework of an effective-field theory. The long-range physics is described through tree-level exchange of the SU(3) Goldstone bosons, while the short-range potential is parametrized in terms of the lowest-order contact terms. We obtain reasonable fits to available weak hypernuclear decay rates and quote the values for the parity-violating asymmetry as predicted by the present effective-field theory.

  4. Effect of transient lambda prophage induction on ultraviolet light resistance and recombination in Escherichia coli.

    PubMed Central

    Braun, A; Gluck, D

    1977-01-01

    Transient induction of lambda prophage increases the ultraviolet light resistance of most exponentially growing Escherichia coli lysogens. Resistance is increased in wild-type, recB, recB recC, recB recC recF, and recB recC recL hosts. No enhancement in recA lysogens was found, nor was there enhancement in stationary cultures. Enhancement was dependent upon the lambdared recombination system. Transient induction also increases the genetic recombination rate in recB lysogens as measured in Hfr X F- matings. PMID:326761

  5. EXOTIC PARTICLE SEARCHES WITH STAR AT RHIC.

    SciTech Connect

    KANABA,S.

    2004-03-15

    We present preliminary results of the STAR experiment at RHIC on exotic particle searches in minimum bias Au + Au collisions at {radical} s{sub NN} = 200 GeV. We observe a narrow peak at 1734 {+-} 0.5 {+-} 5 MeV in the {lambda}K{sub s}{sup 0} invariant mass with width consistent with the experimental resolution of about 6 MeV within the errors. The statistical significance can be quantified between 3 and 6 {sigma} depending on cuts and methods. If this peak corresponds to a real particle state it would be a candidate for the N{sup 0} or the {Xi}{sup 0} I = 1/2 pentaquark states.

  6. Physics of compaction of fine cohesive particles.

    PubMed

    Castellanos, A; Valverde, J M; Quintanilla, M A S

    2005-02-25

    Fluidized fractal clusters of fine particles display critical-like dynamics at the jamming transition, characterized by a power law relating consolidation stress with volume fraction increment [sigma--(c) proportional, variant(Deltaphi)(beta)]. At a critical stress clusters are disrupted and there is a crossover to a logarithmic law (Deltaphi = nu logsigma--(c)) resembling the phenomenology of soils. We measure lambda identical with- partial differentialDelta(1/phi)/ partial log(sigma--(c) proportional, variant Bo(0.2)(g), where Bo(g) is the ratio of interparticle attractive force (in the fluidlike regime) to particle weight. This law suggests that compaction is ruled by the internal packing structure of the jammed clusters at nearly zero consolidation.

  7. Particle preconcentrator

    SciTech Connect

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr

    2000-07-11

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a previous screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  8. Particle preconcentrator

    DOEpatents

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr.

    1998-12-29

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents. 3 figs.

  9. Particle preconcentrator

    DOEpatents

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    1998-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  10. Particle preconcentrator

    DOEpatents

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    2000-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  11. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    2005-09-20

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  12. Investigations of potential bias in the estimation of lambda using Pradel's (1996) model for capture-recapture data

    USGS Publications Warehouse

    Hines, J.E.; Nichols, J.D.

    2002-01-01

    Pradel's (1996) temporal symmetry model permitting direct estimation and modelling of population growth rate, lambda sub i provides a potentially useful tool for the study of population dynamics using marked animals. Because of its recent publication date, the approach has not seen much use, and there have been virtually no investigations directed at robustness of the resulting estimators. Here we consider several potential sources of bias, all motivated by specific uses of this estimation approach. We consider sampling situations in which the study area expands with time and present an analytic expression for the bias in lambda hat sub i. We next consider trap response in capture probabilities and heterogeneous capture probabilities and compute large-sample and simulation-based approximations of resulting bias in lambda hat sub i. These approximations indicate that trap response is an especially important assumption violation that can produce substantial bias. Finally, we consider losses on capture and emphasize the importance of selecting the estimator for lambda sub i that is appropriate to the question being addressed. For studies based on only sighting and resighting data, Pradel's (1996) lambda hat prime sub i is the appropriate estimator.

  13. Spectral enhancement of proteins: biological incorporation and fluorescence characterization of 5-hydroxytryptophan in bacteriophage lambda cI repressor.

    PubMed Central

    Ross, J B; Senear, D F; Waxman, E; Kombo, B B; Rusinova, E; Huang, Y T; Laws, W R; Hasselbacher, C A

    1992-01-01

    We have used a tryptophan-requiring Escherichia coli auxotroph to replace the three tryptophan residues of lambda cI repressor with 5-hydroxy-L-tryptophan (5-OHTrp). By using a nonleaky promoter, we have achieved > 95% replacement of tryptophan in the repressor. We show that the absorbance and fluorescence properties of 5-OHTrp-lambda cI are clearly distinct from lambda cI repressor and that the fluorescence of 5-OHTrp-lambda cI repressor can be observed selectively in the presence of exogenous tryptophan. We also show that the 5-OHTrp-lambda cI repressor functional properties, as assessed by measurement of binding constants for self-association and for association to operator DNA, and structural properties, as assessed by fluorescence, are indistinguishable from the native repressor. Based on these results, we anticipate that the availability of spectrally enhanced proteins will significantly enhance the utility of both fluorescence and phosphorescence spectroscopies to study protein structure and function in complex interacting systems. PMID:1465434

  14. Spherically symmetric solutions, Newton's Law, and the infrared limit {lambda}{yields}1 in covariant Horava-Lifshitz gravity

    SciTech Connect

    Alexandre, Jean; Pasipoularides, Pavlos

    2011-10-15

    In this note we examine whether spherically symmetric solutions in covariant Horava-Lifshitz gravity can reproduce Newton's Law in the IR limit {lambda}{yields}1. We adopt the position that the auxiliary field A is independent of the space-time metric [J. Alexandre and P. Pasipoularides, Phys. Rev. D 83, 084030 (2011).][J. Greenwald, V. H. Satheeshkumar, and A. Wang, J. Cosmol. Astropart. Phys. 12 (2010) 007.], and we assume, as in [A. M. da Silva, Classical Quantum Gravity 28, 055011 (2011).], that {lambda} is a running coupling constant. We show that under these assumptions, spherically symmetric solutions fail to restore the standard Newtonian physics in the IR limit {lambda}{yields}1, unless {lambda} does not run, and has the fixed value {lambda}=1. Finally, we comment on the Horava and Melby-Thompson approach [P. Horava and C. M. Melby-Thompson, Phys. Rev. D 82, 064027 (2010).] in which A is assumed as a part of the space-time metric in the IR.

  15. Cell-type preference of immunoglobulin kappa and lambda gene promoters.

    PubMed Central

    Picard, D; Schaffner, W

    1985-01-01

    Immunoglobulin gene constant regions are known to be associated with strictly tissue-specific enhancer elements. Until recently the promoter of the variable region, which becomes linked to the constant region by somatic rearrangement, could have been viewed as a passive recipient of the enhancer stimulus. Here we show that the promoters of the immunoglobulin kappa and lambda light chain genes are approximately 20-30 times more active in lymphoid cells than in non-lymphoid cells. To avoid the problem of differential mRNA stability upon transfection of immunoglobulin genes into non-lymphoid cells we have constructed chimeric genes. All kappa mRNA sequences were progressively deleted to fuse the kappa gene promoter to a globin gene coding body. A similar chimeric gene was constructed with the promoter of the lambda gene. The cell-type preference of the promoter may be exploited during B-lymphocyte differentiation to regulate the immunoglobulin gene promoter independently from the enhancer. Images Fig. 2. Fig. 4. Fig. 5. Fig. 6. PMID:2998757

  16. HEATING OF THE MAGNETIC CHROMOSPHERE: OBSERVATIONAL CONSTRAINTS FROM Ca II {lambda}8542 SPECTRA

    SciTech Connect

    De la Cruz Rodriguez, J.; De Pontieu, B.; Carlsson, M.; Rouppe van der Voort, L. H. M.

    2013-02-10

    The heating of the Sun's chromosphere remains poorly understood. While progress has been made on understanding what drives the quiet-Sun internetwork chromosphere, chromospheric heating in strong magnetic field regions continues to present a difficult challenge, mostly because of a lack of observational constraints. We use high-resolution spectropolarimetric data from the Swedish 1 m Solar Telescope to identify the location and spatio-temporal properties of heating in the magnetic chromosphere. In particular, we report the existence of raised-core spectral line profiles in the Ca II {lambda}8542 line. These profiles are characterized by the absence of an absorption line core, showing a quasi-flat profile between {lambda} Almost-Equal-To {+-}0.5 A, and are abundant close to magnetic bright points and plage. Comparison with three-dimensional MHD simulations indicates that such profiles occur when the line of sight goes through an ''elevated temperature canopy'' associated with the expansion with height of the magnetic field of flux concentrations. This temperature canopy in the simulations is caused by ohmic dissipation where there are strong magnetic field gradients. The raised-core profiles are thus indicators of locations of increased chromospheric heating. We characterize the location and temporal and spatial properties of such profiles in our observations, thus providing much stricter constraints on theoretical models of chromospheric heating mechanisms than before.

  17. The electromagnetic Sigma-to-Lambda hyperon transition form factors at low energies

    DOE PAGES

    Granados, Carlos; Leupold, Stefan; Perotti, Elisabetta

    2017-06-09

    Using dispersion theory the low-energy electromagnetic form factors for the transition of a Sigma to a Lambda hyperon are related to the pion vector form factor. The additionally required input, i.e. the two-pion-Sigma-Lambda amplitudes are determined from relativistic next-to-leading-order (NLO) baryon chiral perturbation theory including the baryons from the octet and optionally from the decuplet. Pion rescattering is again taken into account by dispersion theory. It turns out that the inclusion of decuplet baryons is not an option but a necessity to obtain reasonable results. The electric transition form factor remains very small in the whole low-energy region. The magneticmore » transition form factor depends strongly on one not very well determined low-energy constant of the NLO Lagrangian. Furthermore, one obtains reasonable predictive power if this low-energy constant is determined from a measurement of the magnetic transition radius. Such a measurement can be performed at the future Facility for Antiproton and Ion Research (FAIR).« less

  18. Reliability analysis of repairable systems using Petri nets and vague Lambda-Tau methodology.

    PubMed

    Garg, Harish

    2013-01-01

    The main objective of the paper is to developed a methodology, named as vague Lambda-Tau, for reliability analysis of repairable systems. Petri net tool is applied to represent the asynchronous and concurrent processing of the system instead of fault tree analysis. To enhance the relevance of the reliability study, vague set theory is used for representing the failure rate and repair times instead of classical(crisp) or fuzzy set theory because vague sets are characterized by a truth membership function and false membership functions (non-membership functions) so that sum of both values is less than 1. The proposed methodology involves qualitative modeling using PN and quantitative analysis using Lambda-Tau method of solution with the basic events represented by intuitionistic fuzzy numbers of triangular membership functions. Sensitivity analysis has also been performed and the effects on system MTBF are addressed. The methodology improves the shortcomings of the existing probabilistic approaches and gives a better understanding of the system behavior through its graphical representation. The washing unit of a paper mill situated in a northern part of India, producing approximately 200 ton of paper per day, has been considered to demonstrate the proposed approach. The results may be helpful for the plant personnel for analyzing the systems' behavior and to improve their performance by adopting suitable maintenance strategies.

  19. Stability of CII is a key element in the cold stress response of bacteriophage lambda infection.

    PubMed Central

    Obuchowski, M; Shotland, Y; Koby, S; Giladi, H; Gabig, M; Wegrzyn, G; Oppenheim, A B

    1997-01-01

    Bacteria are known to adapt to environmental changes such as temperature fluctuations. It was found that temperature affects the lysis-lysogeny decision of lambda such that at body temperature (37 degrees C) the phage can select between the lytic and lysogenic pathways, while at ambient temperature (20 degrees C) the lytic pathway is blocked. This temperature-dependent discriminatory developmental pathway is governed mainly by the phage CII activity as a transcriptional activator. Mutations in cII or point mutations at the pRE promoter lead to an over-1,000-fold increase in mature-phage production at low temperature while mutations in cI cause a smaller increase in phage production. Interference with CII activity can restore lytic growth at low temperature. We found that at low temperature the stability of CII in vivo is greatly increased. It was also found that phage DNA replication is blocked at 20 degrees C but can be restored by supplying O and P in trans. It is proposed that CII hampers transcription of the rightward pR promoter, thus reducing the levels of the lambda O and P proteins, which are necessary for phage DNA replication. Our results implicate CII itself or host proteins affecting CII stability as a "molecular thermometer". PMID:9324241

  20. Stability of CII is a key element in the cold stress response of bacteriophage lambda infection.

    PubMed

    Obuchowski, M; Shotland, Y; Koby, S; Giladi, H; Gabig, M; Wegrzyn, G; Oppenheim, A B

    1997-10-01

    Bacteria are known to adapt to environmental changes such as temperature fluctuations. It was found that temperature affects the lysis-lysogeny decision of lambda such that at body temperature (37 degrees C) the phage can select between the lytic and lysogenic pathways, while at ambient temperature (20 degrees C) the lytic pathway is blocked. This temperature-dependent discriminatory developmental pathway is governed mainly by the phage CII activity as a transcriptional activator. Mutations in cII or point mutations at the pRE promoter lead to an over-1,000-fold increase in mature-phage production at low temperature while mutations in cI cause a smaller increase in phage production. Interference with CII activity can restore lytic growth at low temperature. We found that at low temperature the stability of CII in vivo is greatly increased. It was also found that phage DNA replication is blocked at 20 degrees C but can be restored by supplying O and P in trans. It is proposed that CII hampers transcription of the rightward pR promoter, thus reducing the levels of the lambda O and P proteins, which are necessary for phage DNA replication. Our results implicate CII itself or host proteins affecting CII stability as a "molecular thermometer".

  1. A CI-Independent Form of Replicative Inhibition: Turn Off of Early Replication of Bacteriophage Lambda

    PubMed Central

    Hayes, Sidney; Horbay, Monique A.; Hayes, Connie

    2012-01-01

    Several earlier studies have described an unusual exclusion phenotype exhibited by cells with plasmids carrying a portion of the replication region of phage lambda. Cells exhibiting this inhibition phenotype (IP) prevent the plating of homo-immune and hybrid hetero-immune lambdoid phages. We have attempted to define aspects of IP, and show that it is directed to repλ phages. IP was observed in cells with plasmids containing a λ DNA fragment including oop, encoding a short OOP micro RNA, and part of the lambda origin of replication, oriλ, defined by iteron sequences ITN1-4 and an adjacent high AT-rich sequence. Transcription of the intact oop sequence from its promoter, pO is required for IP, as are iterons ITN3–4, but not the high AT-rich portion of oriλ. The results suggest that IP silencing is directed to theta mode replication initiation from an infecting repλ genome, or an induced repλ prophage. Phage mutations suppressing IP, i.e., Sip, map within, or adjacent to cro or in O, or both. Our results for plasmid based IP suggest the hypothesis that there is a natural mechanism for silencing early theta-mode replication initiation, i.e. the buildup of λ genomes with oop+ oriλ+ sequence. PMID:22590552

  2. The 24 GHz measurements of 2.2 lambda conical horn antennas illuminating a conducting sheet

    NASA Technical Reports Server (NTRS)

    Cross, A. E.; Marshall, R. E.; Hearn, C. P.; Neece, R. T.

    1993-01-01

    Monostatic reflection-coefficient magnitude, absolute value of Gamma, measurements occurring between a radiating horn and a metal reflecting plate are presented for a family of three 2.2 lambda diameter conical horn antennas. The three horns have different aperture phase deviations: 6 deg, 22.5 deg, and 125 deg. Measurements of the magnitude of absolute value of Gamma as a function of horn-plate separation (d) extend from an effective antenna aperture short (d = O) to beyond the far-field boundary (d = 2D(sup 2)/lambda, where D is the antenna diameter). Measurement data are presented with various physical environments for each of the horns. Measured scalar data are compared with theoretical data from two models, a numerical model for a circular waveguide aperture in a ground plane and a scalar diffraction theory model. This work was conducted in support of the development effort for a spaceborne multifrequency microwave reflectometer designed to accurately determine the distance from a space vehicle's surface to a reflecting plasma boundary. The metal reflecting plate was used to simulate the RF reflectivity of a critically dense plasma. The resulting configuration, a ground plane mounted aperture facing a reflecting plane in close proximity, produces a strong interaction between the ground plane and the reflecting plate, especially at integral half-wavelength separations. The transition coefficient is characterized by large amplitude variations.

  3. Monoclonal immunoglobulin M lambda coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant.

    PubMed Central

    Thiagarajan, P; Shapiro, S S; De Marco, L

    1980-01-01

    Prolongation of all phospholipid-dependent coagulation tests was found in a patient with macroglobulinemia, despite absence of bleeding manifestations. The purified monoclonal IgM lambda protein and its Fabmu tryptic fragment induced similar changes in normal plasma. Patient IgM and Fabmu completely inhibited Ca++-dependent binding of radiolabeled prothrombin and Factor X to mixed phospholipid micelles. The patient's IgM lambda paraprotein reacted with phosphatidylserine and, to a lesser extent, with phosphatidylinositol and phosphatidic acid, but not with phosphatidylcholine or phosphatidylethanolamine. Prior incubation of phospholipid with patient Fabmu blocked the positive reactions. Substitution of washed platelets for phospholipid led to normalization of patient coagulation tests and corrected all abnormalities produced in normal plasma by patient IgM. Furthermore, binding of 125I-Factor Xa to thrombin-treated platelets was entirely normal in the presence of patient IgM. These studies support the concept that platelets, rather than phospholipid micelles, are the primary locus of prothrombin and Factor X activation in normal hemostasis. Images PMID:6772673

  4. Performance of Eriopis connexa (Coleoptera: Coccinellidae) resistant to lambda-cyhalothrin after extended recovery from knockdown.

    PubMed

    Santos, D S; Rodrigues, A R S; Torres, J B; Lira, R

    2016-12-01

    A population of the predatory lady beetle Eriopis connexa (Germar) (Coleoptera: Coccinellidae) was recorded as resistant to lambda-cyhalothrin. Adults exposed to this insecticide have recovered from knockdown after 72 h. Thus, the performance of resistant (R) and susceptible (S) populations of E. connexa not exposed to insecticide (R0 and S0) and R adults recovering from knockdown 24, 48, and 72 h after exposure (R24, R48, and R72) was studied. In addition, the fertility life table parameters were calculated for one generation considering the progenies from R0, S0, and R24 populations. The recovery rate from knockdown was 69.4% for R-adults, and greater recovery rate was observed within 48 h following lambda-cyhalothrin exposure. The S-females produced about 50% more eggs and lived longer, when compared with R-females irrespective of the recovery periods after knockdown. The R-females produced similar number of eggs and exhibited similar longevity across all treatments (R0, R24, R48, and R72). Progenies produced by R- and S-populations did not exhibit consistent differences in development and survival. The fertility life table parameters showed higher intrinsic rate of population growth (rm) and lower mean generation time (T) for R0- and R24-females, when compared with those for S0-females. Thus, the time interval needed to recover from knockdown is not related to the adaptive cost of resistance in E. connexa.

  5. Optimizing Oceanographic Big Data Browse and Visualization Response Times by Implementing the Lambda Architecture

    NASA Astrophysics Data System (ADS)

    Currier, R. D.; Howard, M.; Kirkpatrick, B. A.

    2016-02-01

    Visualizing large-scale data sets using standard web-based mapping tools can result in significant delays and response time issues for users. Load times for data sets comprised of millions of records can be in excess of thirty seconds when the data sets are served using traditional architectures and techniques. In this paper we demonstrate the efficiency gains created by utilizing the Lambda Architecture on a low velocity, high volume hypoxia-nutrient decision support system with 25M records. While traditionally employed on high velocity, high volume data we demonstrate significant improvements in data load times and the user browse experience on low velocity, high volume data. Optimizing query and visualization response times becomes increasingly important as data sets grow in size. Time series data from extended autonomous underwater vehicle deployments can exceed 500M records. Applying the Lambda Architecture to these data sets will allow users to browse, visualize and fuse data in a manner not possible using traditional methodologies.

  6. An analytical ultracentrifugation based study on the conformation of lambda carrageenan in aqueous solution.

    PubMed

    Almutairi, Fahad M; Adams, Gary G; Kök, Mehmet S; Lawson, Christopher J; Gahler, Roland; Wood, Simon; Foster, Timothy J; Rowe, Arthur J; Harding, Stephen E

    2013-08-14

    The conformation and heterogeneity of lambda-carrageenan, a sulphonated galactan from red seaweed, solubilised in aqueous solvent with the assistance of microwave irradiation, has been assessed by a combination of analytical ultracentrifugation, size-exclusion chromatography, light scattering and capillary viscometry. Preparations appeared generally unimodal on the basis of sedimentation coefficient distributions from sedimentation velocity although at the highest concentrations a shoulder appears with a sedimentation coefficient approximately 1.1 times greater than that of the main component. Even under conditions commensurate with charge suppression simple linear regression was insufficient to represent non-ideal concentration dependence and the extraction of the Grálen concentration dependence parameter ks. A more general fitting algorithm was therefore employed. Mark-Houwink-Kuhn-Sakurada analysis of the change in intrinsic viscosity [η] with molecular weight, together with the Wales-van Holde ratio (combination of ks with [η]) point to an extended flexible conformation for lambda-carrageenan in the (weight average) molecular weight range Mw=340,000-870,000g/mol. The origin of the larger sedimentation coefficient component appearing at the higher concentrations is considered.

  7. The photodetected function of silicon photoelectronic lambda negative resistance transistor (PLBT)

    NASA Astrophysics Data System (ADS)

    Zhang, Shi-lin; Zhang, Bo; Guo, Wei-lian; Mao, Lu-hong; Zhang, Pei-ning

    2005-01-01

    In this paper, the photo-detected and controlled functions based on silicon photo-electronic Lambda transistor (PLBT) are reported. PLBT is composed of a npn vertical bipolar transistor as main device and a enhancement-mode MOSFET transistor as feedback device which connected in parallel across the base and collector terminals of bipolar transistor. Photo-electronic-lambda bipolar transistor (PLBT) is one important member of Si-photo electronic negative resistance devices. It has wide applications in photo-electronic coupler, light detector, light sensor and other photo-electronic circuit modules, which is significant for the further study of photo-electronic devices and circuits. When the Si-photo-electronic negative transistor device works as a load, it has two stable output states (bistability characteristics) with the change of the input light signals. Using the photo-bistable and self-locking characteristics of the PLBT, a photo-controlled Bistable Logic Circuit Element has been set up successfully. Through detail studying and analyzing to the operation feature and load feature of the photo-controlled bistable circuit, the nonlinear characteristic of the circuit is demonstrated. Furthermore the applications of this circuit element have been studied and verified.

  8. Solar cycle dependence of the sun's radius at lambda = 525.0 nm

    NASA Technical Reports Server (NTRS)

    Ulrich, Roger K.; Bertello, L.

    1995-01-01

    The Mount Wilson (California) synoptic program of solar magnetic observations scans the solar disk between 1 and 20 times per day. As part of this program, the radius is determined as an average distance between the image center and the point where the intensity in the FeI line at lambda = 525.0 nm drops to 25 percent of its value at the disk's center. The data base of information was analyzed and corrected for effects such as scattered light and atmospheric reflection. The solar variability and the measurement techniques are described. The observation data sets, the corrections made to the data, and the observed variations, are discussed. It is stated that similar spectral lines at lambda = 525.0 nm, which are common in the solar spectrum, probably exhibit similar radius changes. All portions of the sun are weighted equally so that it is concluded that, within spectral lines, the radiating area of the sun is increased at the solar maximum.

  9. Three-dimensional theory of quantum memories based on {Lambda}-type atomic ensembles

    SciTech Connect

    Zeuthen, Emil; Grodecka-Grad, Anna; Soerensen, Anders S.

    2011-10-15

    We develop a three-dimensional theory for quantum memories based on light storage in ensembles of {Lambda}-type atoms, where two long-lived atomic ground states are employed. We consider light storage in an ensemble of finite spatial extent and we show that within the paraxial approximation the Fresnel number of the atomic ensemble and the optical depth are the only important physical parameters determining the quality of the quantum memory. We analyze the influence of these parameters on the storage of light followed by either forward or backward read-out from the quantum memory. We show that for small Fresnel numbers the forward memory provides higher efficiencies, whereas for large Fresnel numbers the backward memory is advantageous. The optimal light modes to store in the memory are presented together with the corresponding spin waves and outcoming light modes. We show that for high optical depths such {Lambda}-type atomic ensembles allow for highly efficient backward and forward memories even for small Fresnel numbers F(greater-or-similar sign)0.1.

  10. The electromagnetic Sigma-to-Lambda hyperon transition form factors at low energies

    NASA Astrophysics Data System (ADS)

    Granados, Carlos; Leupold, Stefan; Perotti, Elisabetta

    2017-06-01

    Using dispersion theory the low-energy electromagnetic form factors for the transition of a Sigma to a Lambda hyperon are related to the pion vector form factor. The additionally required input, i.e. the two-pion-Sigma-Lambda amplitudes are determined from relativistic next-to-leading-order (NLO) baryon chiral perturbation theory including the baryons from the octet and optionally from the decuplet. Pion rescattering is again taken into account by dispersion theory. It turns out that the inclusion of decuplet baryons is not an option but a necessity to obtain reasonable results. The electric transition form factor remains very small in the whole low-energy region. The magnetic transition form factor depends strongly on one not very well determined low-energy constant of the NLO Lagrangian. One obtains reasonable predictive power if this low-energy constant is determined from a measurement of the magnetic transition radius. Such a measurement can be performed at the future Facility for Antiproton and Ion Research (FAIR).

  11. NO Detection by Pulsed Polarization of Lambda Probes–Influence of the Reference Atmosphere

    PubMed Central

    Fischer, Sabine; Schönauer-Kamin, Daniela; Pohle, Roland; Fleischer, Maximilian; Moos, Ralf

    2013-01-01

    The pulsed polarization measurement technique using conventional thimble type lambda probes is suitable for low ppm NOx detection in exhaust gas applications. To evaluate the underlying sensor mechanism, the unknown influence of the reference atmosphere on the NO sensing behavior is investigated in this study. Besides answering questions with respect to the underlying principle, this investigation can resolve the main question of whether a simplified sensor element without reference may be also suitable for NO sensing using the pulsed polarization measurement technique. With an adequate sensor setup, the reference atmosphere of the thimble type lambda probe is changed completely after a certain diffusion time. Thus, the sensor response regarding NO is compared with and without different gas atmospheres on both electrodes. It is shown that there is still a very good NO sensitivity even without reference air, although the NO response is reduced due to non-existing overlying mixed potential type voltage, which is otherwise caused by different atmospheres on both electrodes. Considering these results, we see an opportunity to simplify the standard NOx sensor design by omitting the reference electrode.

  12. Processing of Escherichia coli 16S rRNA with bacteriophage lambda leader sequences.

    PubMed Central

    Krych, M; Sirdeshmukh, R; Gourse, R; Schlessinger, D

    1987-01-01

    To test whether any specific 5' precursor sequences are required for the processing of pre-16S rRNA, constructs were studied in which large parts of the 5' leader sequence were replaced by the coliphage lambda pL promoter and adjacent sequences. Unexpectedly, few full-length transcripts of the rRNA were detected after the pL promoter was induced, implying that either transcription was poor or most of the rRNA chains with lambda leader sequences were unstable. Nevertheless, sufficient transcription occurred to permit the detection of processing by S1 nuclease analysis. RNA transcripts in which 2/3 of the normal rRNA leader was deleted (from the promoter up to the normal RNase III cleavage site) were processed to form the normal 5' terminus. Thus, most of the double-stranded stem that forms from sequences bracketing wild-type 16S pre-rRNA is apparently not required for proper processing; the expression of such modified transcripts, however, must be increased before the efficiency of processing of the 16S rRNA formed can be assessed. Images PMID:2445728

  13. Helium-4 Experiments near T-lambda in a Low-Gravity Simulator

    NASA Technical Reports Server (NTRS)

    Liu, Yuanming; Larson, Melora; Israelsson, Ulf

    2000-01-01

    We report our studies of gravity cancellation in a liquid helium sample cell along the lambda-line using a low-gravity simulator facility. The simulator consists of a superconducting magnet capable of producing B(delta-B/delta-z) = 22squareT)/cm. We have verified experimentally that the simulator can cancel gravity to about 0.01g in a cylindrical sample volume of 0.5 cm in diameter and 0.5 cm in height. This allows us to approach more closely the superfluid transition without entering the normal-superfluid two phase region induced by gravity. We also present the measurements of T-c(Q,P): depression of the superfluid transition temperature by a heat current(Q) along the lambda-line (P). The results are consistent with the Renormalization-group theory calculation. Measurements of thermal expansion coefficient in a heat current will also be discussed. The work has been carried out by JPL, California Institute of Technology under contract to NASA.

  14. Observation of Mollow Triplets with Tunable Interactions in Double Lambda Systems of Individual Hole Spins

    NASA Astrophysics Data System (ADS)

    Lagoudakis, K. G.; Fischer, K. A.; Sarmiento, T.; McMahon, P. L.; Radulaski, M.; Zhang, J. L.; Kelaita, Y.; Dory, C.; Müller, K.; Vučković, J.

    2017-01-01

    Although individual spins in quantum dots have been studied extensively as qubits, their investigation under strong resonant driving in the scope of accessing Mollow physics is still an open question. Here, we have grown high quality positively charged quantum dots embedded in a planar microcavity that enable enhanced light-matter interactions. Under a strong magnetic field in the Voigt configuration, individual positively charged quantum dots provide a double lambda level structure. Using a combination of above-band and resonant excitation, we observe the formation of Mollow triplets on all optical transitions. We find that when the strong resonant drive power is used to tune the Mollow-triplet lines through each other, we observe anticrossings. We also demonstrate that the interaction that gives rise to the anticrossings can be controlled in strength by tuning the polarization of the resonant laser drive. Quantum-optical modeling of our system fully captures the experimentally observed spectra and provides insight on the complicated level structure that results from the strong driving of the double lambda system.

  15. Tuning the phase sensitivity of a double-lambda system with a static magnetic field.

    PubMed

    Xu, Xiwei; Shen, Shuo; Xiao, Yanhong

    2013-05-20

    We study the effect of a DC magnetic field on the phase sensitivity of a double-lambda system coupled by two laser fields, a probe and a pump. It is demonstrated that the gain and the refractive index of the probe can be controlled by either the magnetic field or the relative phase between the two laser fields. More interestingly, when the system reduces to a single-lambda system, turning on the magnetic field transforms the system from a phase-insensitive process to a phase-sensitive one. In the pulsed-probe regime, we observed switching between slow and fast light when the magnetic field or the relative phase was adjusted. Experiments using a coated 87Rb vapor cell produced results in good agreement with our numerical simulation. This work provides a novel and simple means to manipulate phase sensitive electromagnetically-induced-transparency or four-wave mixing, and could be useful for applications in quantum optics, nonlinear optics and magnetometery based on such systems.

  16. Convergent mechanisms favor fast amyloid formation in two lambda 6a Ig light chain mutants.

    PubMed

    Valdés-García, Gilberto; Millán-Pacheco, César; Pastor, Nina

    2017-08-01

    Extracellular deposition as amyloids of immunoglobulin light chains causes light chain amyloidosis. Among the light chain families, lambda 6a is one of the most frequent in light chain amyloidosis patients. Its germline protein, 6aJL2, and point mutants, R24G and P7S, are good models to study fibrillogenesis, because their stability and fibril formation characteristics have been described. Both mutations make the germline protein unstable and speed up its ability to aggregate. To date, there is no molecular mechanism that explains how these differences in amyloidogenesis can arise from a single mutation. To look into the structural and dynamical differences in the native state of these proteins, we carried out molecular dynamics simulations at room temperature. Despite the structural similarity of the germline protein and the mutants, we found differences in their dynamical signatures that explain the mutants' increased tendency to form amyloids. The contact network alterations caused by the mutations, though different, converge in affecting two anti-aggregation motifs present in light chain variable domains, suggesting a different starting point for aggregation in lambda chains compared to kappa chains. © 2017 Wiley Periodicals, Inc.

  17. Temperatures of coal particle during devolatilization in fluidized bed combustion reactor

    SciTech Connect

    Komatina, M.; Manovic, V.; Saljnikov, A.

    2006-11-15

    The purpose of this study was to investigate the thermal behavior of coal during devolatilization in fluidized bed. Temperatures in the center of single coal particle were measured by thermocouple. Two coals were tested (brown coal Bogovina and lignite Kosovo), using dry coal particle, shaped into spherical form of diameters 7 and 10 mm, in temperature range from 300 to 850{sup o}C. Unsteady behavior of coal particle during heating and devolatilization in fluidized bed was described by a model that takes into account heat transfer between bed and particle surface, heat transfer through particle and an endothermic chemical reaction of first-order. Based on the mathematical model analysis and compared with experimental results, values of heat conductivity {lambda}{sub C} and heat capacity (C-p) of coal were determined. The best agreement was obtained for constant thermal properties, for brown coal {lambda}{sub C} = 0.20 W/mK and C{sub p} = 1200 J/kgK and for lignite {lambda}{sub C} = 0.17 W/mK and C-p = 1100 J/kgK.

  18. Measurements of the branching fractions for B{sub (s)}{yields}D{sub (s)}{pi}{pi}{pi} and {Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{pi}{pi}

    SciTech Connect

    Aaij, R.; Bauer, Th.; Beuzekom, M. van; Carvalho Akiba, K.; Coco, V.; van Eijk, D.; Farinelli, C.; Heijne, V.; Hulsbergen, W.; Jans, E.; Jansen, F.; Koppenburg, P.; Kozlinskiy, A.; van Leerdam, J.; Merk, M.; Mous, I.; Oggero, S.; Pellegrino, A.; du Pree, T.; Storaci, B.

    2011-11-01

    Branching fractions of the decays H{sub b}{yields}H{sub c}{pi}{sup -}{pi}{sup +}{pi}{sup -} relative to H{sub b}{yields}H{sub c}{pi}{sup -} are presented, where H{sub b} (H{sub c}) represents B{sup 0} (D{sup +}), B{sup -} (D{sup 0}), B{sub s}{sup 0} (D{sub s}{sup +}), and {Lambda}{sub b}{sup 0} ({Lambda}{sub c}{sup +}). The measurements are performed with the LHCb detector using 35 pb{sup -1} of data collected at {radical}(s)=7 TeV. The ratios of branching fractions are measured to be [B(B{sup 0}{yields}D{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup 0}{yields}D{sup +}{pi}{sup -})]=2.38{+-}0.11{+-}0.21, [B(B{sup -}{yields}D{sup 0}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup -}{yields}D{sup 0}{pi}{sup -})]= 1.27{+-}0.06{+-}0.11, [B(B{sub s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sub s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -})]=2.01{+-}0.37{+-}0.20, [B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -} {pi}{sup +}{pi}{sup -})]/[B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -})]=1.43{+-}0.16{+-}0.13 We also report measurements of partial decay rates of these decays to excited charm hadrons. These results are of comparable or higher precision than existing measurements.

  19. Angular Distributions for 3,4 Lambda H Bound States in the 3,4 He(e,e'K+) reaction

    SciTech Connect

    Dohrmann, Frank; Ahmidouch, Abdellah; Armstrong, Christopher; Arrington, John; Asaturyan, Razmik; Avery, Steven; Bailey, Kevin; Hu, Bitao; Breuer, Herbert; Brown, Daniel; Carlini, Roger; Cha, Jinseok; Chant, Nicholas; Christy, Michael; Cochran, Anthony; Cole, Leon; Crowder, J.; Danagoulian, Samuel; Elaasar, Mostafa; Ent, Rolf; Fenker, Howard; Fujii, Yu; Gan, Liping; Garrow, Kenneth; Gueye, Paul; Hafidi, Kawtar; Hinton, Wendy; Juengst, Henry; Keppel, Cynthia; Liang, Yongguang; Liu, Jinghua; Lung, Allison; Mack, David; Markowitz, Pete; Mitchell, Joseph; Miyoshi, Toshinobu; Mkrtchyan, Hamlet; Mtingwa, Sekazi; Mueller, Robert; Niculescu, Gabriel; Niculescu, Maria-Ioana; Potterveld, David; Raue, Brian; Reimer, Paul; Reinhold, Joerg; Roche, Julie; Sarsour, Murad; Sato, Yoshinori; Segel, Ralph; Semenov, Andrei; Stepanyan, Samuel; Tadevosyan, Vardan; Tajima, Shigeyuki; Tang, Liguang; Uzzle, Alicia; Wood, Stephen; Yamaguchi, Hiroshi; Yan, Chen; Yuan, Lulin; Zeidman, Benjamin; Zeier, Markus; Zihlmann, Benedikt

    2004-12-01

    The 3Lambda H and 4Lambda H hypernuclear bound states have been observed for the first time in kaon electroproduction on 3,4He targets. The production cross sections have been determined at Q**2= 0.35 GeV**2 and W= 1.91 GeV. For either hypernucleus the nuclear form factor is determined by comparing the angular distribution of the 3,4He(e,e'K+)3,4Lambda H processes to the elementary cross section 1H(e,e'K+) Lambda on the free proton, measured during the same experiment.

  20. Search for Bbar to Lambda_c+ X l- nu Decays in Events with a Fully Reconstructed B Meson

    SciTech Connect

    Lees, J.P.; Poireau, V.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Milanes, D.A.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Tanabe, T.; Koch, H.; Schroeder, T.; Asgeirsson, D.J.; Hearty, C.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2012-04-19

    We present a search for semileptonic B decays to the charmed baryon {Lambda}{sub c}{sup +} based on 420 fb{sup -1} of data collected at the {Upsilon}(4S) resonance with the BABAR detector at the PEP-II e{sup +}e{sup -} storage rings. By fully reconstructing the recoiling B in a hadronic decay mode, we reduce non-B backgrounds and determine the flavor of the signal B. We statistically correct the flavor for the effect of the B{sup 0} mixing. We obtain a 90% confidence level upper limit of {Beta}({bar B} {yields} {Lambda}{sub c}{sup +} X{ell}{sup -} {bar {nu}}{sub {ell}})/{Beta}({bar B} {yields} {Lambda}{sub c}{sup +} X) < 3.5%.

  1. Toward a bacterial genome technology: integration of the Escherichia coli prophage lambda genome into the Bacillus subtilis 168 chromosome.

    PubMed

    Itaya, M

    1995-07-22

    A novel approach to the cloning large DNAs in the Bacillus subtilis chromosome was examined. An Escherichia coli prophage lambda DNA (48.5 kb) was assembled in the chromosome of B. subtilis. The lambda DNA was first subcloned in four segments, having partially overlapping regions. Assembly of the complete prophage was achieved by successive transformation using three discrete DNA integration modes: overlap-elongation, Campbell-type integration, and gap-filling. In the B. subtilis chromosome, DNA was elongated, using contiguous DNA segments, via overlap-elongation. Jumping from one end of a contiguous DNA stretch to another segment was achieved by Campbell-type integration. The remaining gap was sealed by gap-filling. The incorporated lambda DNA thus assembled was stably replicated as part of the 4188 kb B. subtilis chromosome under non-selective conditions. The present method can be used to accommodate larger DNAs in the B. subtilis chromosome and possible applications of this technique are discussed.

  2. Dynamically generated N* and {Lambda}* resonances in the hidden charm sector around 4.3 GeV

    SciTech Connect

    Wu Jiajun; Molina, R.; Oset, E.; Zou, B. S.

    2011-07-15

    The interactions of D-bar{Sigma}{sub c}-D-bar{Lambda}{sub c}, D-bar*{Sigma}{sub c}-D-bar*{Lambda}{sub c}, and related strangeness channels, are studied within the framework of the coupled-channel unitary approach with the local hidden gauge formalism. A series of meson-baryon dynamically generated relatively narrow N* and {Lambda}* resonances are predicted around 4.3 GeV in the hidden charm sector. We make estimates of production cross sections of these predicted resonances in p-barp collisions for the experiment of antiproton annihilation at Darmstadt (PANDA) at the forthcoming GSI Facility for Antiproton and Ion Research (FAIR) facility.

  3. Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis.

    PubMed

    Wu, Qian; Wei, Zhiguo; Yang, Zhi; Wang, Tao; Ren, Liming; Hu, Xiaoxiang; Meng, Qingyong; Guo, Ying; Zhu, Qinghong; Robert, Jacques; Hammarström, Lennart; Li, Ning; Zhao, Yaofeng

    2010-05-01

    The reptiles are the last major taxon of jawed vertebrates in which immunoglobulin light chain isotypes have not been well characterized. Using the recently released genome sequencing data, we show in this study that the reptile Anolis carolinensis expresses both lambda and kappa light chain genes. The genomic organization of both gene loci is structurally similar to their respective counterparts in mammals. The identified lambda locus contains three constant region genes each preceded by a joining gene segment, and a total of 37 variable gene segments. In contrast, the kappa locus contains only a single constant region gene, and two joining gene segments with a single family of 14 variable gene segments located upstream. Analysis of junctions of the recombined VJ transcripts reveals a paucity of N and P nucleotides in both expressed lambda and kappa sequences. These results help us to understand the generation of the immunoglobulin repertoire in reptiles and immunoglobulin evolution in vertebrates.

  4. Dissipation kinetics of alpha-cypermethrin and lambda-cyhalothrin residues in aboveground part of white mustard (Sinapis alba L.).

    PubMed

    Słowik-Borowiec, Magdalena

    2016-09-01

    Dissipation of simultaneously applied insecticides alpha-cypermethrin and lambda-cyhalothrin was studied in a minor crop, aboveground part of white mustard (Sinapis alba L.). A validated gas chromatographic method (GC-ECD/NPD) was used to determine insecticide residues. Analytical performances were very satisfactory, with expanded uncertainties not higher than 14% (coverage factor k = 2, confidence level 95%). Dissipation of alpha-cypermethrin and lambda-cyhalothrin in white mustard followed first-order kinetics (R(2) between 0.953 and 0.995), with half-lives of 3.1-4.6 and 2.9-3.7 days respectively. Based on the results of this two-year study and the relevant residue regulation, alpha-cypermethrin and lambda-cyhalothrin treatments can be considered safe for crop protection, feeding animals and the environment.

  5. Elementary particles

    NASA Astrophysics Data System (ADS)

    Fritzsch, Harald; Heusch, Karin

    Introduction -- Electrons and atomic nuclei -- Quantum properties of atoms and particles -- The knives of Democritus -- Quarks inside atomic nuclei -- Quantum electrodynamics -- Quantum chromodynamics -- Mesons, baryons, and quarks -- Electroweak interactions -- Grand unification -- Conclusion.

  6. Magnetic particles

    NASA Technical Reports Server (NTRS)

    Chang, Manchium (Inventor); Colvin, Michael S. (Inventor); Rembaum, Alan (Inventor); Richards, Gil F. (Inventor)

    1987-01-01

    Metal oxide containing polymers and particularly styrene, acrylic or protein polymers containing fine, magnetic iron oxide particles are formed by combining a NO.sub.2 -substituted polymer with an acid such as hydrochloric acid in the presence of metal, particularly iron particles. The iron is oxidized to fine, black Fe.sub.3 O.sub.4 particles which deposit selectively on the polymer particles. Nitrated polymers are formed by reacting functionally substituted, nitrated organic compounds such as trinitrobenzene sulfonate or dinitrofluoro benzene with a functionally coreactive polymer such as an amine modified acrylic polymer or a protein. Other transition metals such as cobalt can also be incorporated into polymers using this method.

  7. Auroral particles

    NASA Astrophysics Data System (ADS)

    Evans, David S.

    1987-06-01

    The problems concerning the aurora posed prior to the war are now either solved in principle or were restated in a more fundamental form. The pre-war hypothesis concerning the nature of the auroral particles and their energies was fully confirmed, with the exception that helium and oxygen ions were identified as participating in the auroral particle precipitation in addition to the protons. The nature of the near-Earth energization processes affecting auroral particles was clarified. Charged particle trajectories in various electric field geometries were modeled. The physical problems have now moved from determining the nature and geometry of the electric fields, which accelerate charged particles near the Earth, to accounting for the existence of these electric fields as a natural consequence of the solar wind's interaction with Earth. Ultimately the reward in continuing the work in auroral and magnetospheric particle dynamics will be a deeper understanding of the subtleties of classical electricity and magnetism as applied to situations not blessed with well-defined and invariant geometries.

  8. Auroral particles

    NASA Technical Reports Server (NTRS)

    Evans, David S.

    1987-01-01

    The problems concerning the aurora posed prior to the war are now either solved in principle or were restated in a more fundamental form. The pre-war hypothesis concerning the nature of the auroral particles and their energies was fully confirmed, with the exception that helium and oxygen ions were identified as participating in the auroral particle precipitation in addition to the protons. The nature of the near-Earth energization processes affecting auroral particles was clarified. Charged particle trajectories in various electric field geometries were modeled. The physical problems have now moved from determining the nature and geometry of the electric fields, which accelerate charged particles near the Earth, to accounting for the existence of these electric fields as a natural consequence of the solar wind's interaction with Earth. Ultimately the reward in continuing the work in auroral and magnetospheric particle dynamics will be a deeper understanding of the subtleties of classical electricity and magnetism as applied to situations not blessed with well-defined and invariant geometries.

  9. Importance of aggregation and small ice crystals in cirrus clouds, based on observations and an ice particle growth model

    NASA Technical Reports Server (NTRS)

    Mitchell, David L.; Chai, Steven K.; Dong, Yayi; Arnott, W. Patrick; Hallett, John

    1993-01-01

    The 1 November 1986 FIRE I case study was used to test an ice particle growth model which predicts bimodal size spectra in cirrus clouds. The model was developed from an analytically based model which predicts the height evolution of monomodal ice particle size spectra from the measured ice water content (IWC). Size spectra from the monomodal model are represented by a gamma distribution, N(D) = N(sub o)D(exp nu)exp(-lambda D), where D = ice particle maximum dimension. The slope parameter, lambda, and the parameter N(sub o) are predicted from the IWC through the growth processes of vapor diffusion and aggregation. The model formulation is analytical, computationally efficient, and well suited for incorporation into larger models. The monomodal model has been validated against two other cirrus cloud case studies. From the monomodal size spectra, the size distributions which determine concentrations of ice particles less than about 150 mu m are predicted.

  10. Dynamic Processes in Be Star Atmospheres.. 6; Simultaneous X-Ray, Ultraviolet, and Optical Variations in lambda Eridani

    NASA Technical Reports Server (NTRS)

    Smith, Myron A.; Murakami, T.; Ezuka, H.; Anandarao, B. G.; Chakraborty, A.; Corcoran, M. F.; Hirata, R.

    1995-01-01

    This report describes a joint X ray/ultraviolet/ground based study of the abnormal Be star lambda Eri which has previously shown evidence of X ray flaring from Rosat observations in 1991. The 1991 flare event caught the astronomical hot star community by surprise because x ray flares have not been observed from other single B-type stars, before or since. Both optical (H-alpha) and UV/Voyager observations provide evidence for transient heating events near the surface of lambda Eri.

  11. Spectroscopic studies and structure of 3-methoxy-2 -[(2,4,4,6,6-pentachloro-1,3,5,2{lambda}{sup 5},4{lambda}{sup 5},6{lambda}{sup 5}-triazatriphosphin-2-yl)oxy] benzaldehyde

    SciTech Connect

    Oezay, H.; Yildiz, M.; Uenver, H.; Durlu, T. N.

    2013-01-15

    The compound called 3-methoxy-2- [(2,4,4,6,6-pentachloro-1,3,5,2{lambda}{sup 5},4{lambda}{sup 5},6{lambda}{sup 5}-triazatriphosphin-2-yl)oxy] benzaldehyde has been synthesized from the reaction of 2-hydroxy-3-methoxybenzaldehyde with hexachlorocyclotriphosphazene. It has been characterized by elemental analysis, MS, IR, {sup 1}H NMR, {sup 13}C NMR, {sup 31}P NMR and UV-visible spectroscopic techniques. The structure of the title compound has been determind by X-ray analysis. Crystals are orthorhombic, space group P2{sub 1}2{sub 1}2{sub 1}, Z = 4, a = 7.705(1), b = 12.624(1), c = 17.825(2) A, R{sub 1} = 0.0390 and wR{sub 2} = 0.1074 [I > 2{sigma}(I)], respectively.

  12. Enzymes mediating resistance to lambda-cyhalothrin in Eriopis connexa (Coleoptera: Coccinellidae).

    PubMed

    Rodrigues, Agna R S; Siqueira, Herbert A A; Torres, Jorge B

    2014-03-01

    Resistance to widely used insecticide, lambda-cyhalothrin, was recently reported in the predatory lady beetle Eriopis connexa (Germar) (Coleoptera: Coccinellidae). However, to understand whether metabolic mechanisms underlie such resistance, synergism bioassays and in vitro studies were carried out by using inhibitors and model substrates for enzymatic assays, respectively. The LD50s estimated for susceptible and resistant populations ηg of lambda-cyhalothrin/insect, and thus, a 22-fold difference in resistance ratio. Synergism ratios for the susceptible population with piperonyl butoxide (PBO), diethyl maleate (DEM), triphenyl phosphate (TPP), and S,S,S-tributylphosphorotrithioate (DEF) were respectively 33.8-, 0.24-, 0.35-, and 4.25-fold, while for the resistant population, they were 1463.0-, 0.79-, 0.85-, and 282.6-fold, respectively. The synergized resistance ratios were 0.50-, 2.00-, 6.75-, and 8.77-fold with PBO, DEF, DEM, and TPP, respectively, while resistance was virtually suppressed with DEF. The esterase exhibited 4.16-, 4.03-, and 5.38-fold greater activity towards formation of α-naphthol, β-naphthol, and 4-nitrophenol in the resistant population of E. connexa than in the susceptible population. The activity of esterase depended on concentrations of DEF applied, either using α-naphthol or β-naphthol, which completely inhibited the activity at 636 ηM. The PBO inhibited the β-naphthol formation in approximately 50%, suggesting it as inhibitor of esterases. The activities of glutathione-S-transferase were similar and corresponded to 0.36-0.47 ηmol(-1) min(-1)μg of protein, for S and R populations, respectively. Similarly, the activities of cytochrome P450-dependent microsomal monooxygenases were 0.04 and 0.05 ηmol(-1) min(-1)μg of protein. The native gel indicated that the formation of β-naphthol was completely inhibited by methyl-paraoxon, but only partially inhibited by eserine, TPP, and PBO. Although other studies with DEF and PBO have

  13. Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C

    PubMed Central

    Susser, Simone; Herrmann, Eva; Lange, Christian; Hamdi, Nabila; Müller, Tobias; Berg, Thomas; Perner, Dany; Zeuzem, Stefan; Sarrazin, Christoph

    2014-01-01

    Background IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of IL28B expression. Individualization of interferon alfa-based therapies based on a combination of IL28B/IFN-L4 polymorphisms may help to optimize virologic outcome and economic resources. Methods Optimization of treatment outcome prediction was assessed by combination of different IL28B and IFN-L4 polymorphisms in patients with chronic HCV genotype 1 (n = 385), 2/3 (n = 267), and 4 (n = 220) infection treated with pegylated interferon alfa (PEG-IFN) and ribavirin with (n = 79) or without telaprevir. Healthy people from Germany (n = 283) and Egypt (n = 96) served as controls. Results Frequencies of beneficial IL28B rs12979860 C/C genotypes were lower in HCV genotype 1/4 infected patients in comparison to controls (20–35% vs. 46–47%) this was also true for ss469415590 TT/TT (20–35% vs. 45–47%). Single interferon-lambda SNPs (rs12979860, rs8099917, ss469415590) correlated with sustained virologic response (SVR) in genotype 1, 3, and 4 infected patients while no association was observed for genotype 2. Interestingly, in genotype 3 infected patients, best SVR prediction was based on IFN-L4 genotype. Prediction of SVR with high accuracy (71–96%) was possible in genotype 1, 2, 3 and 4 infected patients who received PEG-IFN/ribavirin combination therapy by selection of beneficial IL28B rs12979860 C/C and/or ss469415590 TT/TT genotypes (p<0.001). For triple therapy with first generation protease inhibitors (PIs) (boceprevir, telaprevir) prediction of high SVR (90%) rates was based on the presence of at least one beneficial genotype of the 3 IFN-lambda SNPs. Conclusion IFN-L4 seems to be the best single predictor of SVR in genotype 3 infected patients. For optimized prediction of SVR by

  14. Coherent manipulation of noise-protected superconducting artificial atoms in the Lambda scheme

    NASA Astrophysics Data System (ADS)

    Di Stefano, P. G.; Paladino, E.; Pope, T. J.; Falci, G.

    2016-05-01

    We propose a protocol for the manipulation of a three-level artificial atom in Lambda (Λ ) configuration. It allows faithful, selective and robust population transfer analogous to stimulated Raman adiabatic passage (Λ -STIRAP), in last-generation superconducting artificial atoms, where protection from noise implies the absence of a direct pump coupling. It combines the use of a two-photon pump pulse with suitable advanced control, operated by a slow modulation of the phase of the external fields, leveraging on the stability of semiclassical microwave drives. This protocol is a building block for manipulation of microwave photons in complex quantum architectures. Its demonstration would be a benchmark for the implementation of a class of multilevel advanced control procedures for quantum computation and microwave quantum photonics in systems based on artificial atoms.

  15. Properties of the Resonance Lambda(1520) as seen in the Forward Electroproduction at JLab Hall A

    SciTech Connect

    I.I. Strakovsky, Y. Qiang, Ya.I. Azimov, W.J. Briscoe, H. Gao, D.W. Higinbotham, V.V. Nelyubin

    2011-10-01

    High-resolution spectrometer measurements of the reaction H(e,e' K+)X at small Q2 are used to extract the mass and width of the Lambda(1520). We investigate dependence of the resonance parameters on different parametrizations of the background and the resonance peak itself. Our final values for the Breit-Wigner parameters are M=1520.4+-0.6(stat)+-1.5(syst) MeV and Gamma=18.6+-1.9(stat)+-1(syst) MeV. The width appears to be more sensitive to the assumptions than the mass. We also estimate, for the first time, the pole position for this resonance and find that both the pole mass and width seem to be smaller than their Breit-Wigner values.

  16. Line shape of a transition between two levels in a three-level {Lambda} configuration

    SciTech Connect

    Han, Hyok Sang; Jeong, Ji Eun; Cho, D.

    2011-09-15

    We report on our study of the line shape of a transition between two levels in a three-level {Lambda} configuration. By using Poisson statistics under the assumption that the atom stays in a two-level steady state before it is optically pumped to the reservoir state, we arrive at a simple analytic expression for the line shape of a three-level atom. This expression reveals a new type of saturation in the time domain, which is conceptually different from that of power-broadening in a two-level atom. It can also be used as a basis for more complicated situations of Doppler-broadened gaseous samples or pump-and-probe spectroscopy. We tested the theory experimentally in an ideal situation of slow pulsed {sup 85}Rb atoms and found excellent agreement. Application to measurements of a branching ratio or a Franck-Condon factor of a diatomic molecule is discussed.

  17. Accelerated quantum control using superadiabatic dynamics in a solid-state lambda system

    NASA Astrophysics Data System (ADS)

    Zhou, Brian B.; Baksic, Alexandre; Ribeiro, Hugo; Yale, Christopher G.; Heremans, F. Joseph; Jerger, Paul C.; Auer, Adrian; Burkard, Guido; Clerk, Aashish A.; Awschalom, David D.

    2017-04-01

    Adiabatic processes are useful for quantum technologies but, despite their robustness to experimental imperfections, they remain susceptible to decoherence due to their long evolution time. A general strategy termed shortcuts to adiabaticity (STA) aims to remedy this vulnerability by designing fast dynamics to reproduce the results of a slow, adiabatic evolution. Here, we implement an STA technique known as superadiabatic transitionless driving (SATD) to speed up stimulated Raman adiabatic passage in a solid-state lambda system. Using the optical transitions to a dissipative excited state in the nitrogen-vacancy centre in diamond, we demonstrate the accelerated performance of different shortcut trajectories for population transfer and for the initialization and transfer of coherent superpositions. We reveal that SATD protocols exhibit robustness to dissipation and experimental uncertainty, and can be optimized when these effects are present. These results suggest that STA could be effective for controlling a variety of solid-state open quantum systems.

  18. Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions.

    PubMed

    Chugha, Preeti; Sage, Harvey J; Oas, Terrence G

    2006-03-01

    Although poorly understood, the properties of the denatured state ensemble are critical to the thermodynamics and the kinetics of protein folding. The most relevant conformations to cellular protein folding are the ones populated under physiological conditions. To avoid the problem of low expression that is seen with unstable variants, we used methionine oxidation to destabilize monomeric lambda repressor and predominantly populate the denatured state under nondenaturing buffer conditions. The denatured ensemble populated under these conditions comprises conformations that are compact. Analytical ultracentrifugation sedimentation velocity experiments indicate a small increase in Stokes radius over that of the native state. A significant degree of alpha-helical structure in these conformations is detected by far-UV circular dichroism, and some tertiary interactions are suggested by near-UV circular dichroism. The characteristics of the denatured state populated by methionine oxidation in nondenaturing buffer are very different from those found in chemical denaturant.

  19. Study of Flow of Superfluid He-II Very Near Tau(sub lambda)

    NASA Technical Reports Server (NTRS)

    Mukharsky, Yury; Sukhatme, Kalyani; Pearson, David; Chui, Talso

    1999-01-01

    We report here, preliminary data from an experiment studying flow of superfluid helium through a slit orifice (of sub-micron width) very close to T(sub lambda). Critical supercurrent (I(sub c)) data is obtained from a step function drive to the diaphragm in a Helmholtz resonator cell. The superfluid density (rho(sub s)) data can be obtained from the resonant frequency of the Helmholtz oscillator, as determined by transfer function of the resonator or from the free ringing after the step function excitation. Preliminary data shows that I(sub c) is proportional to (rho(sub s))(exp 1.27) and rho(sub s)) is proportional to tau(exp 0.73), where tau is the reduced temperature. However, the magnitude of I(sub c) is much larger than expected, indicating a possible parallel flow path. Further investigations are in progress. Keywords: superfluid; hydrodynamics; critical exponent

  20. Restoration of patency after apparent occlusion of the lambda-graft's right branch.

    PubMed

    Bonacchi, M; Prifti, E; Giunti, G; Frati, G

    2001-12-01

    The "string sign" is a physiological and reversible response of the internal mammary artery (IMA) anastomosed to a moderately stenotic coronary artery. We describe a patient who presented postoperatively with a string sign phenomenon of the right branch of the lambda-composite graft. The graft regained full patency 32 months after the surgical procedure with progression of the native coronary artery stenotic lesion. This case demonstrates that under specific conditions, such as the progression of native coronary artery disease, a no-flow composite graft employing IMAs can only regain patency and functional status in the same way as in situ IMAs. These findings confirm that the IMA remains the conduit of choice not only for its long-term patency, but also for its physiological adaptation characteristics.

  1. An Escherichia coli gene required for bacteriophage P2-lambda interference.

    PubMed Central

    Ghisotti, D; Zangrossi, S; Sironi, G

    1983-01-01

    The gene old of bacteriophage P2 is known to (i) cause interference with phage lambda growth; (ii) kill recB- mutants of Escherichia coli after P2 infection; and (iii) determine increased sensitivity of P2 lysogenic cells to X-ray irradiation. In all of these phenomena, inhibition of protein synthesis occurs. We have isolated bacterial mutants, named pin (P2 interference), able to suppress all of the above-mentioned phenomena caused by the old+ gene product and the concurrent protein synthesis inhibition. Pin mutations are recessive, map at 12 min on the E. coli map, and identify a new gene. Satellite bacteriophage P4 does not plate on pin-3 mutant strains and causes cell lethality and protein synthesis inhibition in such mutants. P4 mutants able to grow on pin-3 strains have been isolated. PMID:6355505

  2. Homologous overexpression of a lipase from Burkholderia cepacia using the lambda Red recombinase system.

    PubMed

    Jia, Bin; Yang, Jiang-Ke; Liu, Wen-Shan; Li, Xu; Yan, Yun-Jun

    2010-04-01

    Red recombinase system of the lambda phage is widely used for recombination of short linear DNA fragments and genome. Using this system, we obtained T7 RNA polymerase (RNAP) substitution mutants in Burkholderia cepacia. To test the expression abilities of the T7 mutants, four different lipase expression vectors were transformed and the lipase activity of these recombinants was evaluated. Our results suggest that 500 nt homology between the unit and the genome is sufficient to generate mutations and this strategy enables the rapid establishment of mutant strains with efficiencies of 85%. After expression and purification, the highest purified lipase activity obtained was 3,990 U/l, nearly triple that of the wild-type organism.

  3. Acceptance Studies of an Additional Lambda Disk Detector for the PANDA Experiment

    NASA Astrophysics Data System (ADS)

    Kumar, Ajay; Roy, Ankhi; PANDA Collaboration

    2016-01-01

    The PANDA detector, which studies proton antiproton annihilations, will be installed at the future facility for antiproton and ion research in Darmstadt, Germany. PANDA has a wide physics program including the study of excited hyperon states. One very specific feature of most hyperon ground states are long decay lengths of several centimeters. The innermost tracking detector of PANDA, the Micro Vertex Detector, is not optimized for these long decay lengths. Therefore, an upgrade option is proposed adding two additional disks in the forward region called Lambda Disk Detector. For this new detector acceptance studies have been performed using the decay channel p ‾ p → Λ ‾ Λ → p ‾ pπ+π-. Simulations were carried out using the PandaRoot framework based on FairRoot.

  4. Promoter Interference in a Bacteriophage Lambda Control Region: Effects of a Range of Interpromoter Distances

    PubMed Central

    Strainic, Michael G.; Sullivan, Jennifer J.; Collado-Vides, Julio; deHaseth, Pieter L.

    2000-01-01

    The pR and pRM promoters of bacteriophage lambda direct transcription in divergent directions from start sites separated by 83 phosphodiester bonds. We had previously shown that the presence of an RNA polymerase at pR interfered with open complex formation at pRM and that this effect was alleviated by the deletion of 10 bp between the two promoters. Here we present a detailed characterization of the dependence of the interference on the interpromoter distance. It was found that the reduced interference between the two promoters is unique to the 10-bp deletion. The relief of interference was demonstrated to be due to the facilitation of a step subsequent to RNA polymerase binding to the pRM promoter. A model to explain these observations is proposed. A search of known Escherichia coli promoters identified three pairs of divergent promoters with similar separations to those investigated here. PMID:10613884

  5. Analysis of the velocity law in the wind of the Be star Lambda Pavonis

    NASA Technical Reports Server (NTRS)

    Chen, Haiqi; Ringuelet, Adela; Sahade, Jorge; Kondo, Yoji

    1989-01-01

    This paper reanalyzes the IUE spectra of Lambda Pavonis secured in 1982 (Sahade et al.). It is found that the profiles of the broad UV lines are either rotationally broadened or nonrotationally broadened and that the rotationally broadened profiles can be sorted out in two groups characterized by rotational velocity values of 170 km/s and of 210 km/s, respectively. From the analysis of the rotational and of the radial velocities it is possible to distinguish two regions in the extended atmosphere of the star, namely, a region which is rotating and a region which is expanding. In the rotating region, the radial velocities are about zero, and the rotational velocity increases from 170 km/s to 250 km/s. In the expanding region, the rotational energy dissipates, the wind is accelerated to a maximum of -155 km/s, and farther out it decelerates.

  6. First measurement of transferred polarization in the exclusive ep-->e'K+Lambda--> reaction.

    PubMed

    Carman, D S; Joo, K; Mestayer, M D; Raue, B A; Adams, G; Ambrozewicz, P; Anciant, E; Anghinolfi, M; Armstrong, D S; Asavapibhop, B; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Ball, J P; Barrow, S P; Battaglieri, M; Beard, K; Bektasoglu, M; Bellis, M; Bennhold, C; Bianchi, N; Biselli, A S; Boiarinov, S; Bonner, B E; Bouchigny, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Burkert, V D; Butuceanu, C; Calarco, J R; Carnahan, B; Cazes, A; Cetina, C; Ciciani, L; Clark, R; Cole, P L; Coleman, A; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J P; DeSanctis, E; Degtyarenko, P V; Denizli, H; Dennis, L; DeVita, R; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D; Dragovitsch, P; Dugger, M; Dytman, S; Dzyubak, O P; Eckhause, M; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Fatemi, R; Fedotov, G; Feuerbach, R J; Ficenec, J; Forest, T A; Funsten, H; Gaff, S J; Gai, M; Garçon, M; Gavalian, G; Gilad, S; Gilfoyle, G P; Giovanetti, K L; Girard, P; Golovach, E; Gordon, C I O; Griffioen, K; Grimes, S; Guidal, M; Guillo, M; Guo, L; Gyurjyan, V; Hadjidakis, C; Hakobyan, R S; Hardie, J; Heddle, D; Heimberg, P; Hersman, F W; Hicks, K; Hicks, R S; Holtrop, M; Hu, J; Hyde-Wright, C E; Ishkhanov, B; Ito, M M; Jenkins, D; Kelley, J H; Kellie, J D; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Kramer, L H; Kuang, Y; Kuhn, S E; Kuhn, J; Lachniet, J; Laget, J M; Lawrence, D; Li, J; Livingston, K; Longhi, A; Lukashin, K; Manak, J J; Marchand, C; Mart, T; McAleer, S; McCarthy, J; McNabb, J W C; Mecking, B A; Mehrabyan, S; Melone, J J; Meyer, C A; Mikhailov, K; Minehart, R; Mirazita, M; Miskimen, R; Mokeev, V; Morand, L; Morrow, S A; Mozer, M U; Muccifora, V; Mueller, J; Murphy, L Y; Mutchler, G S; Napolitano, J; Nasseripour, R; Nelson, S O; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Rielly, G V; Opper, A K; Osipenko, M; Park, K; Paschke, K; Pasyuk, E; Peterson, G; Pivnyuk, N; Pocanic, D; Pogorelko, O; Polli, E; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Ronchetti, F; Rossi, P; Rowntree, D; Rubin, P; Sabatié, F; Sabourov, K; Salgado, C; Santoro, J; Sapunenko, V; Schumacher, R A; Serov, V S; Sharabian, Y G; Shaw, J; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Sober, D I; Spraker, M; Stavinsky, A; Stepanyan, S; Stoler, P; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Todor, L; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weinstein, L B; Weller, H; Weygand, D P; Whisnant, C S; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zhang, B; Zhao, J; Zhou, Z

    2003-04-04

    The first measurements of the transferred polarization for the exclusive e-->p-->e(')K+Lambda--> reaction have been performed at Jefferson Laboratory using the CLAS spectrometer. A 2.567 GeV beam was used to measure the hyperon polarization over Q2 from 0.3 to 1.5 (GeV/c)(2), W from 1.6 to 2.15 GeV, and over the full K+ center-of-mass angular range. Comparison with predictions of hadrodynamic models indicates strong sensitivity to the underlying resonance contributions. A nonrelativistic quark-model interpretation of our data suggests that the ssmacr; quark pair is produced with spins predominantly antialigned. Implications for the validity of the most widely used quark-pair creation operator are discussed.

  7. IUE observations of cool stars - Alpha Aurigae, HR1099, Lambda Andromedae, and Epsilon Eridani

    NASA Technical Reports Server (NTRS)

    Linsky, J. L.; Ayres, T. R.; Basri, G. S.; Morrison, N. D.; Boggess, A.; Schiffer, F. H., III; Holm, A.; Cassatella, A.; Heck, A.; Macchetto, F.

    1978-01-01

    Initial IUE observations of four cool stars are reported. Observed fluxes and surface fluxes are given for several UV emission lines in the spectral range 1175-2000 A, obtained at low and high dispersion with the short-wavelength spectrograph and camera. These lines are formed in the outer atmospheres of these stars, in regions presumably analogous to the solar chromosphere and transition region. The surface fluxes in the lines increase along the sequence: quiet sun, Epsilon Eri, Lambda And, Alpha Aur, and HR1099. The 2.8-d RS CVn-type binary HR1099, observed on 1 March 1978 near the end of a major flaring episode, has line surface fluxes roughly 100 times that of the quiet sun, similar to those seen in solar flares. Line profiles and flux ratios in multiplets for Capella are presented, and comments given on the opacity of the lines and on a tendency of line width to increase with temperature of formation.

  8. Evaluation of Stability and Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin

    PubMed Central

    Cui, Bo; Feng, Lei; Pan, Zhenzhong; Yu, Manli; Zeng, Zhanghua; Sun, Changjiao; Zhao, Xiang; Wang, Yan; Cui, Haixin

    2015-01-01

    Pesticides are essential agrochemicals used to protect plants from diseases, pests and weeds. However, the formulation defects of conventional pesticides cause food toxicity and ecological environmental problems. In this study, a novel, efficient and environmentally friendly formulation of lambda-cyhalothrin, a solid nanodispersion, was successfully developed based on melt-emulsification and high-speed shearing methods. The solid nanodispersion presented excellent advantages over conventional pesticide formulations in such formulation functions as dispersibility, stability and bioavailability. The formulation is free of organic solvents, and the use of surfactant is reduced. Therefore, the application of the solid nanodispersion in crop production will improve efficacy and reduce the occurrence of both pesticide residues in food and environmental pollution from pesticides. PMID:26281043

  9. Effect of experimental magnetic storm on the production of lambda phage.

    PubMed

    Chervinets, V M

    1979-01-01

    1. Sharp fluctuation of the intensity of the vertical component of the MF amounting to +/- 0.1 Oe changing the sign over each 3 min causes variability of both lysogenic and indicator strains of E. coli. This testifies to an extremely low threshold of their magnetic susceptibility and to biological importance of fluctuations of natural parameters of the geomagnetic field as an ecological factor of the environment. 2. A change in the intensity of the vertical component of the MF, not any higher than +/-0.1 Oe, inhibits phage production in the lysogenic system of E. coli K = 12 lambda and is also reflected in the morphological peculiarities of negative phage colonies as well as in the phage-susceptibility of the E. coli indicator strain.

  10. Isospin Decomposition of the Photoproduced Sigma pi System Near the Lambda(1405)

    SciTech Connect

    Schumacher, Reinhard A.; Moriya, Kei

    2013-09-01

    Recent experimental results for the reaction \\gamma + p \\to K^+ + \\Sigma + \\pi\\ from CLAS at Jefferson Lab are discussed. It was found that the mass distributions or "line shapes" of the three charge combinations \\Sigma^+ \\pi^-, \\Sigma^0 \\pi^0 and \\Sigma^- \\pi^+ differ significantly. Our results show that the \\Lambda(1405), as the I=0 constituent of the reaction, must be accompanied by an I > 0 component. We discuss phenomenological fits to the data to test the possible forms and magnitudes of these amplitudes. A two-amplitude I=0 fit of Breit-Wigner form to the \\Sigma^0\\pi^0 channel alone works quite well. The addition of a single I=1 amplitude works fairly well to model all the line shapes simultaneously.

  11. Structural analysis of a plant sucrose carrier using monoclonal antibodies and bacteriophage lambda surface display.

    PubMed

    Stolz, J; Ludwig, A; Stadler, R; Biesgen, C; Hagemann, K; Sauer, N

    1999-06-25

    Monoclonal antibodies were raised and selected against recombinant Plantago major PmSUC2 sucrose carrier protein. Epitopes of two monoclonal antibodies (PS2-1A2 and PS2-4D4) were mapped using N-terminally truncated PmSUC2 proteins and a lambda library displaying random PmSUC2 peptides. PS2-1A2 recognizes an octapeptide close to the N-terminus of PmSUC2, PS2-4D4 binds to a decapeptide at the very C-terminus. Analyses of antibody binding to yeast protoplasts with functionally active, tagged PmSUC2 protein revealed that both epitopes are located in cytoplasmic domains of PmSUC2. These results support a model for plant sucrose transporters containing 12 transmembrane helices with the N-terminus and the C-terminus on the cytoplasmic side of the plasma membrane.

  12. Analysis of the velocity law in the wind of the Be star Lambda Pavonis

    NASA Technical Reports Server (NTRS)

    Chen, Haiqi; Ringuelet, Adela; Sahade, Jorge; Kondo, Yoji

    1989-01-01

    This paper reanalyzes the IUE spectra of Lambda Pavonis secured in 1982 (Sahade et al.). It is found that the profiles of the broad UV lines are either rotationally broadened or nonrotationally broadened and that the rotationally broadened profiles can be sorted out in two groups characterized by rotational velocity values of 170 km/s and of 210 km/s, respectively. From the analysis of the rotational and of the radial velocities it is possible to distinguish two regions in the extended atmosphere of the star, namely, a region which is rotating and a region which is expanding. In the rotating region, the radial velocities are about zero, and the rotational velocity increases from 170 km/s to 250 km/s. In the expanding region, the rotational energy dissipates, the wind is accelerated to a maximum of -155 km/s, and farther out it decelerates.

  13. The Amazing COS FUV (1320 - 1460 A) Spectrum of (lambda) Vel (K4Ib-II)

    NASA Technical Reports Server (NTRS)

    Carpenter, Kenneth

    2010-01-01

    The FUV spectrum (1320-1460 A) of the K4 lb-11 supergiant (lambda) Vel was observed with the Cosmic Origins Spectrograph (COS) on HST, as part of the Ayres and Redfield Cycle 17 SNAP program "SNAPing Coronal Iron". This spectrum covers a region not previously recorded in (lambda) Vel at high resolution and, in a mere 20 minutes of exposure, reveals a treasure trove of information. It shows a wide variety of strong emission lines, superposed on a bright continuum, with contributions from both atomic and molecular species. Multiple absorptions, including numerous Ni II and Fe II lines, are visible over this continuum, which is likely generated in the chromosphere of the star. Evidence of the stellar wind is seen in the P Cygni profiles of the CII lines near 1335 A and the results of fluorescence processes are visible throughout the region. The spectrum has remarkable similarities to that of (alpha) Boo (K1.5 III), but significant differences as well, including substantial FUV continuum emission, reminiscent of the M2 Iab supergiant (alpha) Ori, but minus the CO fundamental absorption bands seen in the spectrum of the latter star. However, fluoresced CO emission is present, as in the K-giant stars (alpha) Boo and (alpha) Tau (K5 III). The presence of hot plasma in the atmosphere of the star, indicated by previous GHRS observations of Si III] and C III] lines near 1900 A and FUSE observations of O VI 1032 A, is further confirmed by the detection in this COS spectrum of the Si IV UV 1 lines near 1400 A, though both lines are contaminated by overlying fluorescent H2 emission. We present the details of this spectrum, in comparison with stars of similar temperature or luminosity and discuss the implications for the structure of, and the radiative processes active in, the outer atmospheres of these stars.

  14. Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci

    PubMed Central

    1993-01-01

    Pro and pre B cells possess the long-term capacity to proliferate in vitro on stromal cells and interleukin 7 (IL-7) and can differentiate to surface immunoglobulin (sIg+) cells upon removal of IL-7 from the cultures. A key event in this differentiation is the extensive cell loss due to apoptosis. Because the proto-oncogene bcl-2 can promote cell survival, we established pre-B cell lines from E mu-bcl-2 transgenic mice. These pre-B cells have the same properties as those derived from non-bcl-2 transgenic mice except that they do not die by apoptosis. This allowed us to study the fate of newly formed B cells in vitro for a longer period of time. Here we show that early during the differentiation of pre-B cells, upregulation of RAG-1 and RAG-2 expression go hand in hand with rearrangements of the Ig gene loci. Moreover, the newly formed sIg+ B cells continue to express RAG-1 and RAG-2 and continue to rearrange L chain gene loci, even in the absence of proliferation, in an orderly fashion, so that kappa L+ sIg+ cells can become lambda L+ sIg+ or sIg- cells, whereas lambda L+ sIg+ cells can become sIg-, but not kappa L+ sIg+ cells. Thus, deposition of a complete Ig molecule on the surface of a B cell does not automatically stop the Ig-rearrangement machinery. PMID:8376934

  15. Light element non-LTE abundances of lambda Bootis stars. II. Nitrogen and sulphur

    NASA Astrophysics Data System (ADS)

    Kamp, I.; Iliev, I. Kh.; Paunzen, E.; Pintado, O. I.; Solano, E.; Barzova, I. S.

    2001-09-01

    One of the main characteristics proclaimed for the group of the lambda Bootis stars is the apparent solar abundance of the light elements C, N, O and S. The typical abundance pattern is completed by the strong underabundances of the Fe-peak elements. In the first paper of this series, we have shown that carbon is less abundant than oxygen but both elements are still significantly more abundant than Fe-peak elements. The mean abundances, based on a detailed non-LTE investigation, were found -0.37 dex and -0.07 dex, respectively. As a further step, we now present non-LTE abundances of nitrogen and sulphur for thirteen members of the lambda Bootis group based on several spectral lines between 8590 Å, and 8750 Å. Furthermore, LTE abundances for calcium in the same spectral range were derived and compared with values from the literature. Similar to the mean abundances of carbon and oxygen, nearly solar values were found (-0.30 dex for nitrogen and -0.11 dex for sulphur) for our sample of program stars. Among our sample, one previously undetected binary system (HD 64491) was identified. From a statistical point of view, the abundances of the light elements range from slightly overabundant to moderately underabundant compared to the Sun. However, the individual objects always exhibit a similiar pattern, with the Fe-peak elements being significantly more underabundant than the light elements. No correlation of the derived abundances with astrophysical parameters such as the effective temperature, surface gravity or projected rotational velocity was found. Furthermore, the abundances of the light elements do not allow us to discriminate between any proposed theory. Based on observations obtained at BNAO Rozhen and Complejo Astronómico el Leoncito (CASLEO), operated under the agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba y San Juan.

  16. Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection

    PubMed Central

    Li, Josephine H.; Lao, Xiang Qian; Tillmann, Hans L.; Rowell, Jennifer; Patel, Keyur; Thompson, Alexander; Suchindran, Sunil; Muir, Andrew J.; Guyton, John R.; Gardner, Stephen D.; McHutchison, John G.; McCarthy, Jeanette J.

    2010-01-01

    Background Recently, genetic polymorphisms occurring in the interferon lambda gene region were associated with response to interferon-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and interferon therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to interferon. We sought to determine if the interferon lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic HCV infection, not currently undergoing treatment, using multivariable analysis of variance. Results Levels of total cholesterol (p=6.0×10-4), apolipoprotein B (p=1.3×10-6) and low density lipoprotein (LDL) cholesterol (p=8.9×10-10) were significantly higher in subjects carrying the rs12979860 CC ‘responder’ genotype compared to those with the CT or TT genotype. Levels of triglycerides (p=0.03), apolipoprotein A-I (p=0.06) and apolipoprotein E (p=0.01) were slightly lower in the rs12979860 CC genotype group, while levels of high density lipoprotein cholesterol (p=0.78) and apolipoprotein C-III (p=0.74) did not vary by rs12979860 genotype. Conclusions Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous interferon response to hepatitis C and that subjects with the rs12979860 CC ‘responder’ genotype may have a lower endogenous interferon response to the virus. PMID:20235331

  17. Human placenta: relative content of antibodies of different classes and subclasses (IgG1-IgG4) containing lambda- and kappa-light chains and chimeric lambda-kappa-immunoglobulins.

    PubMed

    Lekchnov, Evgenii A; Sedykh, Sergey E; Dmitrenok, Pavel S; Buneva, Valentina N; Nevinsky, Georgy A

    2015-06-01

    The specific organ placenta is much more than a filter: it is an organ that protects, feeds and regulates the growth of the embryo. Affinity chromatography, ELISA, SDS-PAGE and matrix-assisted laser desorption ionization mass spectrometry were used. Using 10 intact human placentas deprived of blood, a quantitative analysis of average relative content [% of total immunoglobulins (Igs)] was carried out for the first time: (92.7), IgA (2.4), IgM (2.5), kappa-antibodies (51.4), lambda-antibodies (48.6), IgG1 (47.0), IgG2 (39.5), IgG3 (8.8) and IgG4 (4.3). It was shown for the first time that placenta contains sIgA (2.5%). In the classic paradigm, Igs represent products of clonal B-cell populations, each producing antibodies recognizing a single antigen. There is a common belief that IgGs in mammalian biological fluids are monovalent molecules having stable structures and two identical antigen-binding sites. However, similarly to human milk Igs, placenta antibodies undergo extensive half-molecule exchange and the IgG pool consists of 43.5 ± 15.0% kappa-kappa-IgGs and 41.6 ± 17.0% lambda-lambda-IgGs, while 15.0 ± 4.0% of the IgGs contained both kappa- and lambda-light chains. Kappa-kappa-IgGs and lambda-lambda-IgGs contained, respectively (%): IgG1 (47.7 and 34.4), IgG2 (36.3 and 44.5), IgG3 (7.4 and 11.8) and IgG4 (7.5 and 9.1), while chimeric kappa-lambda-IgGs consisted of (%): 43.5 IgG1, 41.0 IgG2, 5.6 IgG3 and 7.9 IgG4. Our data are indicative of the possibility of half-molecule exchange between placenta IgGs of various subclasses, raised against different antigens, which explains a very well-known polyspecificity and cross-reactivity of different human IgGs.

  18. Carbon particles

    DOEpatents

    Hunt, Arlon J.

    1984-01-01

    A method and apparatus whereby small carbon particles are made by pyrolysis of a mixture of acetylene carried in argon. The mixture is injected through a nozzle into a heated tube. A small amount of air is added to the mixture. In order to prevent carbon build-up at the nozzle, the nozzle tip is externally cooled. The tube is also elongated sufficiently to assure efficient pyrolysis at the desired flow rates. A key feature of the method is that the acetylene and argon, for example, are premixed in a dilute ratio, and such mixture is injected while cool to minimize the agglomeration of the particles, which produces carbon particles with desired optical properties for use as a solar radiant heat absorber.

  19. Stable particles

    SciTech Connect

    Samios, N.P.

    1993-12-31

    I have been asked to review the subject of stable particles, essentially the particles that eventually comprised the meson and baryon octets. with a few more additions -- with an emphasis on the contributions made by experiments utilizing the bubble chamber technique. In this activity, much work had been done by the photographic emulsion technique and cloud chambers-exposed to cosmic rays as well as accelerator based beams. In fact, many if not most of the stable particles were found by these latter two techniques, however, the forte of the bubble chamber (coupled with the newer and more powerful accelerators) was to verify, and reinforce with large statistics, the existence of these states, to find some of the more difficult ones, mainly neutrals and further to elucidate their properties, i.e., spin, parity, lifetimes, decay parameters, etc.

  20. Particle Sizer

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Microspheres are tiny plastic beads that represent the first commercial products manufactured in orbit. An example of how they are used is a new aerodynamic particle sizer designated APS 33B produced by TSI Incorporated. TSI purchased the microspheres from the National Bureau of Standards which certified their exact size and the company uses them in calibration of the APS 33B* instrument, latest in a line of TSI systems for generating counting and weighing minute particles of submicron size. Instruments are used for evaluating air pollution control devices, quantifying environments, meteorological research, testing filters, inhalation, toxicology and other areas where generation or analysis of small airborne particles is required. * The APS 33B is no longer being manufactured. An improved version, APS 3320, is now being manufactured. 2/28/97

  1. Comparison Between Dust Particle Generation In CH4 or CH4/N2 Mixing RF Plasmas

    SciTech Connect

    Pereira, Jeremy; Massereau-Guilbaud, Veronique; Geraud-Grenier, Isabelle; Plain, Andre

    2005-10-31

    Dust particles have been spontaneously generated either in pure CH4 or in CH4/N2 r.f. plasmas. The dust particle formation results from homogeneous nucleation in the plasma and is detected by laser light scattering (Ar+, {lambda} = 514.5 nm). The temporal and spatial behaviour of dust particles is studied. In pure methane gas, particles are trapped in well defined clouds at the plasma sheath boundaries. In a CH4/N2 mixture, the nitrogen addition leads to an expansion of the clouds. For nitrogen contents higher than 50%, the space between the electrodes is nearly completely filled with dust particles leading to plasma instabilities and a void appears in the center of the discharge. The particles are spherical with diameters in the range 0.8-2 {mu}m. For nitrogen-rich plasmas, the particles growth is improved and leads to a rough shape with an orange-peel-type surface texture.

  2. Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.

    PubMed Central

    Zou, Y R; Takeda, S; Rajewsky, K

    1993-01-01

    The production of lambda chain-expressing B cells was studied in mice in which either the gene encoding the constant region of the kappa chain (C kappa) or the intron enhancer in the Ig kappa locus was inactivated by insertion of a neomycin resistance gene. The two mutants have similar phenotypes: in heterozygous mutant mice the fraction of lambda chain-bearing B cells is twice that in the wildtype. Homozygous mutants produce approximately 7 times more lambda-expressing B cells (and about 2.3 times fewer total B cells) in the bone marrow than their normal counterparts, suggesting that B cell progenitors can differentiate into either kappa- or lambda-producing cells and do the latter in the mutants. Whereas gene rearrangements in the Ig kappa locus are blocked in the case of enhancer inactivation, they still occur in that of the C kappa mutant, although in this mutant RS rearrangement is lower than in the wildtype. This indicates that gene rearrangements in the Ig lambda locus can occur in the absence of a putative positive signal resulting from gene rearrangements in Ig kappa, including RS recombination. Complementing these results, we also present data indicating that in normal B cell development kappa chain rearrangement can be preceded by lambda chain rearrangement and that the frequency of kappa/lambda double producers is small and insufficient to explain the massive production of lambda chain-expressing B cells in the mutants. Images PMID:8458339

  3. Regional Listening Forums: An Examination of the Methodologies Used by the Child Welfare League of America and Lambda Legal to Highlight the Experiences of LGBTQ Youth in Care

    ERIC Educational Resources Information Center

    Woronoff, Rob; Estrada, Rudy

    2006-01-01

    In 2002, the Child Welfare League of America (CWLA) and the Lambda Legal Defense and Education Fund began Fostering Transitions: CWLA/Lambda Joint Initiative to Support LGBTQ Youth and Adults Involved with the Child Welfare System. To document the needs of lesbian, gay, bisexual, transgender, and questioning (LGBTQ) youth, as well as identify…

  4. It's Not the Book, It's Not the Author, It's the Award: The Lambda Literary Award and the Case for Strategic Essentialism

    ERIC Educational Resources Information Center

    Crisp, Thomas

    2011-01-01

    On September 16, 2009, the Lambda Literary Foundation (LLF) released a statement revising their eligibility guidelines for the Lambda Literary Award, the most prestigious citation offered for LGBT books and authors. This criteria, which demands that an author must self-identify as a member of the LGBT family of writers, has been met with…

  5. Lethal Effects of Lambda-Cyhalothrin and Demand® CS on Asian Longhorned Beetle, Anoplophora glabripennis (Coleoptera: Cerambycidae): Implications for Population Suppression, Tree Protection, Eradication and Containment

    USDA-ARS?s Scientific Manuscript database

    We evaluated the 24h contact toxicity of lambda-cyhalothrin for adult Asian longhorned beetle, Anoplophora glabripennis Motschulsky, using topical application. Results showed that beetles are sensitive to lambda-cyhalothrin: the LD50 and LD90 were 0.13639 and 0.78461µg/beetle, respectively. Residual...

  6. Exclusive neutral strange particle production from double Pomeron exchange produced by proton-proton interactions at radical s = 62 GeV

    SciTech Connect

    Skeens, J.

    1990-09-21

    Data are presented for the first time on exclusive Pomeron-Pomeron interactions which produce a neutral strange and neutral antistrange particle pair in a central system X. In this paper, the system, X, is identified as one of the following neutral combinations; K{sub s}{sup 0}K{sub s}{sup 0}, K{sub s}{sup 0}K{sup {plus minus}}{pi}{sup {minus plus}}, {Lambda}{sup 0}{bar {Lambda}}{sup 0}, {Lambda}{sup 0}{bar {Lambda}}{sup 0}*. These data were obtained in proton-proton collisions at {radical}s = 62 GeV at the CERN ISR. The triggering systems used to obtain these data are described, followed by a description of the data. The central system mass distributions are presented along with differential mass cross section estimates. A broad enhancement is seen in the K{sub s}{sup 0}K{sub s}{sup 0} system at a mass of 1.2 GeV, and is likely to have the quantum numbers J{sup PC} = 0{sup ++}. Total cross section estimates of 1.3 {plus minus} .64 {mu}b in the K{sub 2}{sup 0}K{sub s}{sup 0} system, . 44 {plus minus} .14 {mu}b in the K{sub s}{sup 0}K{sup {plus minus}}{pi}{sup {minus plus}} system, .20 {plus minus} .14 {mu}b in the {Lambda}{sup 0}{bar {Lambda}}{sup 0} system, and .13 {plus minus} .06 {mu}b in the {Lambda}{sup 0}{bar {Lambda}}{sup 0}* system are obtained.

  7. Particle Geophysics

    NASA Astrophysics Data System (ADS)

    Tanaka, Hiroyuki K. M.

    2014-05-01

    Geophysics research has long been dominated by classical mechanics, largely disregarding the potential of particle physics to augment existing techniques. The purpose of this article is to review recent progress in probing Earth's interior with muons and neutrinos. Existing results for various volcanological targets are reviewed. Geoneutrinos are also highlighted as examples in which the neutrino probes elucidate the composition of Earth's deep interior. Particle geophysics has the potential to serve as a useful paradigm to transform our understanding of Earth as dramatically as the X-ray transformed our understanding of medicine and the body.

  8. Spectroscopic investigation of Lambda hypernuclei in the wide mass region using the (e, e-prime K+) reaction

    SciTech Connect

    Satoshi N. Nakamura

    2011-09-01

    The third generation spectroscopic study of {Lambda} hypernuclei using (e,e'K{sup +}) reaction (JLab E05-115) was performed at JLab Hall-C in 2009. The experiment introduced the newly developed high-resolution electron spectrometer (HES) with the existing high-resolution kaon spectrometer (HKS). Experimental configuration, conditions, spectrometer designs and current status of analysis are presented.

  9. Influence of selected water quality characteristics on the toxicity of lambda-cyhalothrin and gamma-cyhalothrin to Hyalella azteca

    USDA-ARS?s Scientific Manuscript database

    This study was conducted to assess the influence of suspended solids, dissolved organic carbon, and phytoplankton (as chlorophyll a) water quality characteristics on lambda-cyhalothrin and gamma-cyhalothrin aqueous toxicity to Hyalella azteca using natural water from 12 ponds and lakes in Mississipp...

  10. Particle blender

    DOEpatents

    Willey, Melvin G.

    1981-01-01

    An infinite blender that achieves a homogeneous mixture of fuel microspheres is provided. Blending is accomplished by directing respective groups of desired particles onto the apex of a stationary coaxial cone. The particles progress downward over the cone surface and deposit in a space at the base of the cone that is described by a flexible band provided with a wide portion traversing and in continuous contact with the circumference of the cone base and extending upwardly therefrom. The band, being attached to the cone at a narrow inner end thereof, causes the cone to rotate on its arbor when the band is subsequently pulled onto a take-up spool. As a point at the end of the wide portion of the band passes the point where it is tangent to the cone, the blended particles are released into a delivery tube leading directly into a mold, and a plate mounted on the lower portion of the cone and positioned between the end of the wide portion of the band and the cone assures release of the particles only at the tangent point.

  11. Airborne Particles.

    ERIC Educational Resources Information Center

    Ojala, Carl F.; Ojala, Eric J.

    1987-01-01

    Describes an activity in which students collect airborne particles using a common vacuum cleaner. Suggests ways for the students to convert their data into information related to air pollution and human health. Urges consideration of weather patterns when analyzing the results of the investigation. (TW)

  12. PARTICLE ACCELERATOR

    DOEpatents

    Teng, L.C.

    1960-01-19

    ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

  13. Measurement of neutral strange particle production in the underlying event in proton-proton collisions at sqrt(s) = 7 TeV

    SciTech Connect

    Chatrchyan, Serguei; et al.

    2013-09-01

    Measurements are presented of the production of primary K(S)0 and Lambda particles in proton-proton collisions at sqrt(s) = 7 TeV in the region transverse to the leading charged-particle jet in each event. The average multiplicity and average scalar transverse momentum sum of K(S)0 and Lambda particles measured at pseudorapidities abs(eta) < 2 rise with increasing charged-particle jet pt in the range 1-10 GeV and saturate in the region 10-50 GeV. The rise and saturation of the strange particle yields and transverse momentum sums in the underlying event are similar to those observed for inclusive charged particles, which confirms the impact-parameter picture of multiple parton interactions. The results are compared to recent tunes of the PYTHIA Monte Carlo event generator. The PYTHIA simulations underestimate the data by 15-30% for K(S)0 mesons and by about 50% for Lambda baryons, a deficit similar to that observed for the inclusive strange particle production in non-single-diffractive proton-proton collisions. The constant strange- to charged-particle activity ratios and the similar trends for mesons and baryons indicate that the multiparton-interaction dynamics is decoupled from parton hadronization, which occurs at a later stage.

  14. Stability, ghost, and strong coupling in nonrelativistic general covariant theory of gravity with {lambda}{ne}1

    SciTech Connect

    Huang Yongqing; Wang Anzhong

    2011-05-15

    In this paper, we investigate three important issues: stability, ghost, and strong coupling, in the Horava-Melby-Thompson setup of the Horava-Lifshitz theory with {lambda}{ne}1, generalized recently by da Silva. We first develop the general linear scalar perturbations of the Friedmann-Robertson-Walker (FRW) universe with arbitrary spatial curvature and find that an immediate by-product of the setup is that, in all the inflationary models described by a scalar field, the FRW universe is necessarily flat. Applying them to the case of the Minkowski background, we find that it is stable, and, similar to the case {lambda}=1, the spin-0 graviton is eliminated. The vector perturbations vanish identically in the Minkowski background. Thus, similar to general relativity, a free gravitational field in this setup is completely described by a spin-2 massless graviton, even with {lambda}{ne}1. We also study the ghost problem in the FRW background and find explicitly the ghost-free conditions. To study the strong coupling problem, we consider two different kinds of spacetimes, all with the presence of matter: one is cosmological, and the other is static. We find that the coupling becomes strong for a process with energy higher than M{sub pl}|c{sub {psi}|}{sup 5/2} in the flat FRW background and M{sub pl}|c{sub {psi}|}{sup 3} in a static weak gravitational field, where |c{sub {psi}|{identical_to}}|(1-{lambda})/(3{lambda}-1)|{sup 1/2}.

  15. Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains.

    PubMed

    del Pozo Yauner, Luis; Ortiz, Ernesto; Sánchez, Rosalba; Sánchez-López, Rosana; Güereca, Leopoldo; Murphy, Charles L; Allen, Amy; Wall, Jonathan S; Fernández-Velasco, D Alejandro; Solomon, Alan; Becerril, Baltazar

    2008-08-01

    Light chain-associated amyloidosis is a fatal disease characterized by the aggregation and pathologic deposition of monoclonal light chain-related fragments as amyloid fibrils in organs or tissues throughout the body. Notably, it has been observed that proteins encoded by the lambda variable light chain (V(L)) gene segment 6a are invariably associated with amyloid deposition; however, the contribution of the gene to this phenomenon has not been established. In this regard, we have determined the thermodynamic stability and kinetics of in vitro fibrillogenesis of a recombinant (r) V(L) protein, designated 6aJL2, which contains the predicted sequences encoded by the 6a and JL2 germline genes. Additionally, we studied a 6a mutant (6aJL2-Arg25Gly), that is present in approximately 25% of all amyloid-associated lambda6 light chains. Remarkably, the wild-type 6aJL2 protein was more stable than were all known amyloidogenic kappa and lambda light chains for which stability parameters are available; more importantly, it was even more so (and less fibrillogenic) than the only clinically proven nonamyloidogenic lambda6 protein, Jto. Conversely, the mutated 6aJL2-R25G molecule was considerably less stable and more fibrillogenic than was the native 6aJL2. Our data indicate that the propensity of lambda6 light chains to form amyloid can not be attributed to thermodynamic instability of the germline-encoded Vlambda6 domain, but rather, is dependent on sequence alterations that render such proteins amyloidogenic.

  16. Particle acceleration

    NASA Technical Reports Server (NTRS)

    Vlahos, L.; Machado, M. E.; Ramaty, R.; Murphy, R. J.; Alissandrakis, C.; Bai, T.; Batchelor, D.; Benz, A. O.; Chupp, E.; Ellison, D.

    1986-01-01

    Data is compiled from Solar Maximum Mission and Hinothori satellites, particle detectors in several satellites, ground based instruments, and balloon flights in order to answer fundamental questions relating to: (1) the requirements for the coronal magnetic field structure in the vicinity of the energization source; (2) the height (above the photosphere) of the energization source; (3) the time of energization; (4) transistion between coronal heating and flares; (5) evidence for purely thermal, purely nonthermal and hybrid type flares; (6) the time characteristics of the energization source; (7) whether every flare accelerates protons; (8) the location of the interaction site of the ions and relativistic electrons; (9) the energy spectra for ions and relativistic electrons; (10) the relationship between particles at the Sun and interplanetary space; (11) evidence for more than one acceleration mechanism; (12) whether there is single mechanism that will accelerate particles to all energies and also heat the plasma; and (13) how fast the existing mechanisms accelerate electrons up to several MeV and ions to 1 GeV.

  17. Particle classifier

    SciTech Connect

    Etkin, B.

    1987-04-14

    This patent describes a classifier for particulate material comprising a housing having an inlet to receive a classifying air flow flowing in a given direction, collection means downstream of the inlet to receive material classified by the air flow, and material introduction means intermediate the inlet and the collection means to introduce particles entrained in a secondary air stream into the housing in a direction other than the given direction. The material introduction means includes a material outlet aperture in a wall of the housing extending generally perpendicular to the given direction, conveying means to convey material and the secondary air stream to the material outlet and diverting means to divert the secondary air stream to a direction generally parallel to the classifying air flow flowing in the given direction. The diverting means includes a surface extending downstream from the outlet and adjacent thereto and being dimensioned to divert the secondary airstream by a Coanda effect generally parallel to the given direction and thereby segregate the secondary air/stream from the particles and permit continued movement of the particles along predictable trajectories.

  18. KARAT-LAMBDA - frequency dependent ray-traced troposphere delays for space applications

    NASA Astrophysics Data System (ADS)

    Hobiger, Thomas; Baron, Philippe

    2014-05-01

    Space-geodetic microwave techniques work under the assumption that the only dispersive, i.e. frequency dependent delay contribution is caused by the ionosphere. In general, the refractivity, even for the troposphere, is a complex quantity which can be denoted as N = N0 + (N'(f) + i N''(f)) where N0 is a frequency independent term, and N'(f) and N''(f) represent the complex frequency dependence. Thereby, the imaginary part can be used to derive the loss of energy (absorption) and the real part can be assigned to the changes in the propagation velocity (refraction) and thus describes the delay of an electromagnetic wave which propagates through that medium. Although the frequency dependent delay contribution appears to be of small order, one has to consider that signals are propagating through few kilometers of troposphere at high elevations to hundredths of kilometers at low elevations. Therefore, the Kashima Ray-Tracing package (Hobiger et al., 2008) has been modified (and named KARAT-LAMBDA) to enable the consideration of a frequency dependent refractivity. By using this tool, it was studied if and to which extent future space geodetic instruments are affected from dispersive troposphere delays. Moreover, a semi-empirical correction model for the microwave link of the Atomic Clock Ensemble in Space (ACES) has been developed, based on ray-tracing calculations with KARAT-LAMBDA. The proposed model (Hobiger et al., 2013) has been tested with simulated ISS overflights at different potential ACES ground station sites and it could be demonstrated that this model is capable to remove biases and elevation dependent features caused by the dispersive troposphere delay difference between the up-link and down-link. References: T. Hobiger, R. Ichikawa, T. Kondo, and Y. Koyama (2008), Fast and accurate ray-tracing algorithms for real-time space geodetic applications using numerical weather models, Journal of Geophysical Research, vol. 113, iss. D203027, pp. 1-14. T. Hobiger, D

  19. Scaling Properties of Particle Density Fields Formed in Simulated Turbulent Flows

    NASA Technical Reports Server (NTRS)

    Hogan, Robert C.; Cuzzi, Jeffrey N.; Dobrovolskis, Anthony R.; DeVincenzi, Donald (Technical Monitor)

    1998-01-01

    Direct numerical simulations (DNS) of particle concentrations in fully developed 3D turbulence were carried out in order to study the nonuniform structure of the particle density field. Three steady-state turbulent fluid fields with Taylor microscale Reynolds numbers (Re(sub lambda)) of 40, 80 and 140 were generated by solving the Navier-Stokes equations with pseudospectral methods. Large scale forcing was used to drive the turbulence and maintain temporal stationarity. The response of the particles to the fluid was parameterized by the particle Stokes number St, defined as the ratio of the particle's stopping time to the mean period of eddies on the Kolmogorov scale (eta). In this paper, we consider only passive particles optimally coupled to these eddies (St approx. = 1) because of their tendency to concentrate more than particles with lesser or greater St values. The trajectories of up to 70 million particles were tracked in the equilibrated turbulent flows until the particle concentration field reached a statistically stationary state. The nonuniform structure of the concentration fields was characterized by the multifractal singularity spectrum, f(alpha), derived from measures obtained after binning particles into cells ranging from 2(eta) to 15(eta) in size. We observed strong systematic variations of f(alpha) across this scale range in all three simulations and conclude that the particle concentration field is not statistically self similar across the scale range explored. However, spectra obtained at the 2(eta), 4(eta), and 8(eta) scales of each flow case were found to be qualitatively similar. This result suggests that the local structure of the particle concentration field may be flow-Independent. The singularity spectra found for 2n-sized cells were used to predict concentration distributions in good agreement with those obtained directly from the particle data. This Singularity spectrum has a shape similar to the analogous spectrum derived for the

  20. Scaling Properties of Particle Density Fields Formed in Simulated Turbulent Flows

    NASA Technical Reports Server (NTRS)

    Hogan, Robert C.; Cuzzi, Jeffrey N.; Dobrovolskis, Anthony R.; DeVincenzi, Donald (Technical Monitor)

    1998-01-01

    Direct numerical simulations (DNS) of particle concentrations in fully developed 3D turbulence were carried out in order to study the nonuniform structure of the particle density field. Three steady-state turbulent fluid fields with Taylor microscale Reynolds numbers (Re(sub lambda)) of 40, 80 and 140 were generated by solving the Navier-Stokes equations with pseudospectral methods. Large scale forcing was used to drive the turbulence and maintain temporal stationarity. The response of the particles to the fluid was parameterized by the particle Stokes number St, defined as the ratio of the particle's stopping time to the mean period of eddies on the Kolmogorov scale (eta). In this paper, we consider only passive particles optimally coupled to these eddies (St approx. = 1) because of their tendency to concentrate more than particles with lesser or greater St values. The trajectories of up to 70 million particles were tracked in the equilibrated turbulent flows until the particle concentration field reached a statistically stationary state. The nonuniform structure of the concentration fields was characterized by the multifractal singularity spectrum, f(alpha), derived from measures obtained after binning particles into cells ranging from 2(eta) to 15(eta) in size. We observed strong systematic variations of f(alpha) across this scale range in all three simulations and conclude that the particle concentration field is not statistically self similar across the scale range explored. However, spectra obtained at the 2(eta), 4(eta), and 8(eta) scales of each flow case were found to be qualitatively similar. This result suggests that the local structure of the particle concentration field may be flow-Independent. The singularity spectra found for 2n-sized cells were used to predict concentration distributions in good agreement with those obtained directly from the particle data. This Singularity spectrum has a shape similar to the analogous spectrum derived for the