A Seamless Handoff Scheme with Access Point Load Balance for Real-Time Services Support in 802.11 Wireless LANs

NASA Astrophysics Data System (ADS)

Manodham, Thavisak; Loyola, Luis; Miki, Tetsuya

IEEE 802.11 wirelesses LANs (WLANs) have been rapidly deployed in enterprises, public areas, and households. Voice-over-IP (VoIP) and similar applications are now commonly used in mobile devices over wireless networks. Recent works have improved the quality of service (QoS) offering higher data rates to support various kinds of real-time applications. However, besides the need for higher data rates, seamless handoff and load balancing among APs are key issues that must be addressed in order to continue supporting real-time services across wireless LANs and providing fair services to all users. In this paper, we introduce a novel access point (AP) with two transceivers that improves network efficiency by supporting seamless handoff and traffic load balancing in a wireless network. In our proposed scheme, the novel AP uses the second transceiver to scan and find neighboring STAs in the transmission range and then sends the results to neighboring APs, which compare and analyze whether or not the STA should perform a handoff. The initial results from our simulations show that the novel AP module is more effective than the conventional scheme and a related work in terms of providing a handoff process with low latency and sharing traffic load with neighbor APs.

A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

PubMed Central

2015-01-01

Lanthipeptides are a class of ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs) that typically harbor multiple intramolecular thioether linkages. For class II lanthipeptides, these cross-links are installed in a multistep reaction pathway by a single enzyme (LanM). The multifunctional nature of LanMs and the manipulability of their genetically encoded peptide substrates (LanAs) make LanM/LanA systems promising targets for the engineering of new antibacterial compounds. Here, we report the development of a semiquantitative mass spectrometry-based assay for kinetic characterization of LanM-catalyzed reactions. The assay was used to conduct a comparative kinetic analysis of two LanM enzymes (HalM2 and ProcM) that exhibit drastically different substrate selectivity. Numerical simulation of the kinetic data was used to develop models for the multistep HalM2- and ProcM-catalyzed reactions. These models illustrate that HalM2 and ProcM have markedly different catalytic efficiencies for the various reactions they catalyze. HalM2, which is responsible for the biosynthesis of a single compound (the Halβ subunit of the lantibiotic haloduracin), catalyzes reactions with higher catalytic efficiency than ProcM, which modifies 29 different ProcA precursor peptides during prochlorosin biosynthesis. In particular, the rates of thioether ring formation are drastically reduced in ProcM, likely because this enzyme is charged with installing a variety of lanthipeptide ring architectures in its prochlorosin products. Thus, ProcM appears to pay a kinetic price for its relaxed substrate specificity. In addition, our kinetic models suggest that conformational sampling of the LanM/LanA Michaelis complex could play an important role in the kinetics of LanA maturation. PMID:25409537

Effects of Dim Light at Night on Food Intake and Body Mass in Developing Mice.

PubMed

Cissé, Yasmine M; Peng, Juan; Nelson, Randy J

2017-01-01

Appropriately timed light is critical for circadian organization; exposure to dim light at night (dLAN) disrupts temporal organization of endogenous biological timing. Exposure to dLAN in adult mice is associated with elevated body mass and changes in metabolism putatively driven by voluntary changes in the time of food intake. We predicted that exposure of young mice to LAN could affect adult metabolic function. At 3 weeks (Experiment 1) or 5 weeks (Experiment 2) of age, mice were either maintained in standard light-dark (DARK) cycles or exposed to nightly dLAN (5 lux). In the first two experiments, food intake and locomotor activity were assessed after 4 weeks and a glucose tolerance test was administered after 6 weeks in experimental lighting conditions. In Experiment 3, tissues were collected around the clock at 6 h intervals to investigate rhythmic hepatic clock gene expression in mice exposed to dLAN from 3 or 5 weeks of age. Male and female mice exposed to dLAN beginning at 3 weeks of age displayed similar growth rates and body mass to DARK-reared offspring, despite increasing day-time food intake. Exposure to dLAN beginning at 5 weeks of age increased body mass and daytime food intake in male, but not female, mice. Consistent with the body mass phenotype, clock gene expression was unaltered in the liver. In contrast to adults, dLAN exposure during the development of the peripheral circadian system has sex- and development-dependent effects on body mass gain.

Forensic Carving of Network Packets and Associated Data Structures

DTIC Science & Technology

2011-01-01

establishment of prior connection activity and services used; identification of other systems present on the system’s LAN or WLAN; geolocation of the...identification of other systems present on the system?s LAN or WLAN; geolocation of the host computer system; and cross-drive analysis. We show that network...Finally, our work in geolocation was assisted by geo- location databases created by companies such as Google (Google Mobile, 2011) and Skyhook

Research and development of a NYNEX switched multi-megabit data service prototype system

NASA Astrophysics Data System (ADS)

Maman, K. H.; Haines, Robert; Chatterjee, Samir

1991-02-01

Switched Multi-megabit Data Service (SMDS) is a proposed high-speed packet-switched service which will support broadband applications such as Local Area Network (LAN) interconnections across a metropolitan area and beyond. This service is designed to take advantage of evolving Metropolitan Area Network (MAN) standards and technology which will provide customers with 45-mbps and 1 . 5-mbps access to high-speed public data communications networks. This paper will briefly discuss SMDS and review its architecture including the Subscriber Network Interface (SNI) and the SMDS Interface Protocol (SIP). It will review the fundamental features of SMDS such as address screening addressing scheme and access classes. Then it will describe the SMDS prototype system developed in-house by NYNEX Science Technology.

Cislan-2 extension final document by University of Twente (Netherlands)

NASA Astrophysics Data System (ADS)

Niemegeers, Ignas; Baumann, Frank; Beuwer, Wim; Jordense, Marcel; Pras, Aiko; Schutte, Leon; Tracey, Ian

1992-01-01

Results of worked performed under the so called Cislan extension contract are presented. The adaptation of the Cislan 2 prototype design to an environment of interconnected Local Area Networks (LAN's) instead of a single 802.5 token ring LAN is considered. In order to extend the network architecture, the Interconnection Function (IF) protocol layer was subdivided into two protocol layers: a new IF layer, and below the Medium Enhancement (ME) protocol layer. Some small enhancements to the distributed bandwidth allocation protocol were developed, which in fact are also applicable to the 'normal' Cislan 2 system. The new services and protocols are described together with some scenarios and requirements for the new internetting Cislan 2 system. How to overcome the degradation of the quality of speech due to packet loss on the LAN subsystem was studied. Experiments were planned in order to measure this speech quality degradation. Simulations were performed of two Cislan subsystems, the bandwidth allocation protocol and the clock synchronization mechanism. Results on both simulations, performed on SUN workstations using QNAP as a simulation tool, are given. Results of the simulations of the clock synchronization mechanism, and results of the simulation of the distributed bandwidth allocation protocol are given.

Access Point Selection for Multi-Rate IEEE 802.11 Wireless LANs

DTIC Science & Technology

2014-05-16

Mobile Systems, Applications and Services, 2006. [2] S . Vasudevan, K. Papagiannaki, C . Diot, J. Kurose, and D. Towsley, “Facilitating Access Point...LANs 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) University of California at Berkeley,Electrical Engineering and Computer Sciences,Berkeley,CA,94720 8

Using OpenSSH to secure mobile LAN network traffic

NASA Astrophysics Data System (ADS)

Luu, Brian B.; Gopaul, Richard D.

2002-08-01

Mobile Internet Protocol (IP) Local Area Network (LAN) is a technique, developed by the U.S. Army Research Laboratory, which allows a LAN to be IP mobile when attaching to a foreign IP-based network and using this network as a means to retain connectivity to its home network. In this paper, we describe a technique that uses Open Secure Shell (OpenSSH) software to ensure secure, encrypted transmission of a mobile LAN's network traffic. Whenever a mobile LAN, implemented with Mobile IP LAN, moves to a foreign network, its gateway (router) obtains an IP address from the new network. IP tunnels, using IP encapsulation, are then established from the gateway through the foreign network to a home agent on its home network. These tunnels provide a virtual two-way connection to the home network for the mobile LAN as if the LAN were connected directly to its home network. Hence, when IP mobile, a mobile LAN's tunneled network traffic must traverse one or more foreign networks that may not be trusted. This traffic could be subject to eavesdropping, interception, modification, or redirection by malicious nodes in these foreign networks. To protect network traffic passing through the tunnels, OpenSSH is used as a means of encryption because it prevents surveillance, modification, and redirection of mobile LAN traffic passing across foreign networks. Since the software is found in the public domain, is available for most current operating systems, and is commonly used to provide secure network communications, OpenSSH is the software of choice.

LAN (Local Area Network) Interoperability Study of Protocols Needed for Distributed Command and Control

DTIC Science & Technology

1985-03-01

model referred to by the study group . IMCKIiN cuINICATION 31215FOR SDATA TWSU•l Sa *BSTtEO POOTO• AA14FTICT’WI PEM1 ITS ...operating systems, compared the DOD and ISO networking protocol architecture models , the protocols for LAN’s developed by the IEEE and ANSI, reviewed and...be initiated, so as to provide the Air Force a roadmap to guide its * "technology develop •ents. 4,’ �/LAN 3-4 .°. SECTION 4.0

Chronic dim light at night provokes reversible depression-like phenotype: possible role for TNF.

PubMed

Bedrosian, T A; Weil, Z M; Nelson, R J

2013-08-01

The prevalence of major depression has increased in recent decades and women are twice as likely as men to develop the disorder. Recent environmental changes almost certainly have a role in this phenomenon, but a complete set of contributors remains unspecified. Exposure to artificial light at night (LAN) has surged in prevalence during the past 50 years, coinciding with rising rates of depression. Chronic exposure to LAN is linked to increased risk of breast cancer, obesity and mood disorders, although the relationship to mood is not well characterized. In this study, we investigated the effects of chronic exposure to 5 lux LAN on depression-like behaviors in female hamsters. Using this model, we also characterized hippocampal brain-derived neurotrophic factor expression and hippocampal dendritic morphology, and investigated the reversibility of these changes 1, 2 or 4 weeks following elimination of LAN. Furthermore, we explored the mechanism of action, focusing on hippocampal proinflammatory cytokines given their dual role in synaptic plasticity and the pathogenesis of depression. Using reverse transcription-quantitative PCR, we identified a reversible increase in hippocampal tumor necrosis factor (TNF), but not interleukin-1β, mRNA expression in hamsters exposed to LAN. Direct intracerebroventricular infusion of a dominant-negative inhibitor of soluble TNF, XPro1595, prevented the development of depression-like behavior under LAN, but had no effect on dendritic spine density in the hippocampus. These results indicate a partial role for TNF in the reversible depression-like phenotype observed under chronic dim LAN. Recent environmental changes, such as LAN exposure, may warrant more attention as possible contributors to rising rates of mood disorders.

An abstract model of rogue code insertion into radio frequency wireless networks. The effects of computer viruses on the Program Management Office

NASA Astrophysics Data System (ADS)

Feudo, Christopher V.

1994-04-01

This dissertation demonstrates that inadequately protected wireless LANs are more vulnerable to rogue program attack than traditional LANs. Wireless LANs not only run the same risks as traditional LANs, but they also run additional risks associated with an open transmission medium. Intruders can scan radio waves and, given enough time and resources, intercept, analyze, decipher, and reinsert data into the transmission medium. This dissertation describes the development and instantiation of an abstract model of the rogue code insertion process into a DOS-based wireless communications system using radio frequency (RF) atmospheric signal transmission. The model is general enough to be applied to widely used target environments such as UNIX, Macintosh, and DOS operating systems. The methodology and three modules, the prober, activator, and trigger modules, to generate rogue code and insert it into a wireless LAN were developed to illustrate the efficacy of the model. Also incorporated into the model are defense measures against remotely introduced rogue programs and a cost-benefit analysis that determined that such defenses for a specific environment were cost-justified.

Dim light at night increases depressive-like responses in male C3H/HeNHsd mice.

PubMed

Fonken, Laura K; Nelson, Randy J

2013-04-15

Daily patterns of light exposure have become increasingly variable since the widespread adoption of electrical lighting during the 20th century. Seasonal fluctuations in light exposure, shift-work, and transmeridian travel are all associated with alterations in mood. These studies implicate fluctuations in environmental lighting in the development of depressive disorders. Here we argue that exposure to light at night (LAN) may be causally linked to depression. Male C3H/HeNHsd mice, which produce nocturnal melatonin, were housed in either a standard light/dark (LD) cycle or exposed to nightly dim (5 lux) LAN (dLAN). After four weeks in lighting conditions mice underwent behavioral testing and hippocampal tissue was collected at the termination of the study for qPCR. Here were report that mice exposed to dLAN increase depressive-like responses in both a sucrose anhedonia and forced swim test. In contrast to findings in diurnal grass rats, dLAN mice perform comparably to mice housed under dark nights in a hippocampus-dependent learning and memory task. TNFα and IL1β gene expression do not differ between groups, demonstrating that changes in these pro-inflammatory cytokines do not mediate dLAN induced depressive-like responses in mice. BDNF expression is reduced in the hippocampus of mice exposed to dLAN. These results indicate that low levels of LAN can alter mood in mice. This study along with previous work implicates LAN as a potential factor contributing to depression. Further understanding of the mechanisms through which LAN contributes to changes in mood is important for characterizing and treating depressive disorders. Copyright © 2013 Elsevier B.V. All rights reserved.

Satellite-derived land covers for runoff estimation using SCS-CN method in Chen-You-Lan Watershed, Taiwan

NASA Astrophysics Data System (ADS)

Zhang, Wen-Yan; Lin, Chao-Yuan

2017-04-01

The Soil Conservation Service Curve Number (SCS-CN) method, which was originally developed by the USDA Natural Resources Conservation Service, is widely used to estimate direct runoff volume from rainfall. The runoff Curve Number (CN) parameter is based on the hydrologic soil group and land use factors. In Taiwan, the national land use maps were interpreted from aerial photos in 1995 and 2008. Rapid updating of post-disaster land use map is limited due to the high cost of production, so the classification of satellite images is the alternative method to obtain the land use map. In this study, Normalized Difference Vegetation Index (NDVI) in Chen-You-Lan Watershed was derived from dry and wet season of Landsat imageries during 2003 - 2008. Land covers were interpreted from mean value and standard deviation of NDVI and were categorized into 4 groups i.e. forest, grassland, agriculture and bare land. Then, the runoff volume of typhoon events during 2005 - 2009 were estimated using SCS-CN method and verified with the measured runoff data. The result showed that the model efficiency coefficient is 90.77%. Therefore, estimating runoff by using the land cover map classified from satellite images is practicable.

LAN attack detection using Discrete Event Systems.

PubMed

Hubballi, Neminath; Biswas, Santosh; Roopa, S; Ratti, Ritesh; Nandi, Sukumar

2011-01-01

Address Resolution Protocol (ARP) is used for determining the link layer or Medium Access Control (MAC) address of a network host, given its Internet Layer (IP) or Network Layer address. ARP is a stateless protocol and any IP-MAC pairing sent by a host is accepted without verification. This weakness in the ARP may be exploited by malicious hosts in a Local Area Network (LAN) by spoofing IP-MAC pairs. Several schemes have been proposed in the literature to circumvent these attacks; however, these techniques either make IP-MAC pairing static, modify the existing ARP, patch operating systems of all the hosts etc. In this paper we propose a Discrete Event System (DES) approach for Intrusion Detection System (IDS) for LAN specific attacks which do not require any extra constraint like static IP-MAC, changing the ARP etc. A DES model is built for the LAN under both a normal and compromised (i.e., spoofed request/response) situation based on the sequences of ARP related packets. Sequences of ARP events in normal and spoofed scenarios are similar thereby rendering the same DES models for both the cases. To create different ARP events under normal and spoofed conditions the proposed technique uses active ARP probing. However, this probing adds extra ARP traffic in the LAN. Following that a DES detector is built to determine from observed ARP related events, whether the LAN is operating under a normal or compromised situation. The scheme also minimizes extra ARP traffic by probing the source IP-MAC pair of only those ARP packets which are yet to be determined as genuine/spoofed by the detector. Also, spoofed IP-MAC pairs determined by the detector are stored in tables to detect other LAN attacks triggered by spoofing namely, man-in-the-middle (MiTM), denial of service etc. The scheme is successfully validated in a test bed. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

Optical Ethernet

NASA Astrophysics Data System (ADS)

Chan, Calvin C. K.; Lam, Cedric F.; Tsang, Danny H. K.

2005-09-01

Call for Papers: Optical Ethernet The Journal of Optical Networking (JON) is soliciting papers for a second feature issue on Optical Ethernet. Ethernet has evolved from a LAN technology connecting desktop computers to a universal broadband network interface. It is not only the vehicle for local data connectivity but also the standard interface for next-generation network equipment such as video servers and IP telephony. High-speed Ethernet has been increasingly assuming the volume of backbone network traffic from SONET/SDH-based circuit applications. It is clear that IP has become the universal network protocol for future converged networks, and Ethernet is becoming the ubiquitous link layer for connectivity. Network operators have been offering Ethernet services for several years. Problems and new requirements in Ethernet service offerings have been captured through previous experience. New study groups and standards bodies have been formed to address these problems. This feature issue aims at reviewing and updating the new developments and R&D efforts of high-speed Ethernet in recent years, especially those related to the field of optical networking. Scope of Submission The scope of the papers includes, but is not limited to, the following: Ethernet PHY development 10-Gbit Ethernet on multimode fiber Native Ethernet transport and Ethernet on legacy networks EPON Ethernet OAM Resilient packet ring (RPR) and Ethernet QoS definition and management on Ethernet Ethernet protection switching Circuit emulation services on Ethernet Transparent LAN service development Carrier VLAN and Ethernet Ethernet MAC frame expansion Ethernet switching High-speed Ethernet applications Economic models of high-speed Ethernet services Ethernet field deployment and standard activities To submit to this special issue, follow the normal procedure for submission to JON, indicating "Optical Ethernet feature" in the "Comments" field of the online submission form. For all other questions relating to this feature issue, please send an e-mail to jon@osa.org, subject line "Optical Ethernet." Additional information can be found on the JON website: http://www.osa-jon.org/submission/

Grid accounting service: state and future development

NASA Astrophysics Data System (ADS)

Levshina, T.; Sehgal, C.; Bockelman, B.; Weitzel, D.; Guru, A.

2014-06-01

During the last decade, large-scale federated distributed infrastructures have been continually developed and expanded. One of the crucial components of a cyber-infrastructure is an accounting service that collects data related to resource utilization and identity of users using resources. The accounting service is important for verifying pledged resource allocation per particular groups and users, providing reports for funding agencies and resource providers, and understanding hardware provisioning requirements. It can also be used for end-to-end troubleshooting as well as billing purposes. In this work we describe Gratia, a federated accounting service jointly developed at Fermilab and Holland Computing Center at University of Nebraska-Lincoln. The Open Science Grid, Fermilab, HCC, and several other institutions have used Gratia in production for several years. The current development activities include expanding Virtual Machines provisioning information, XSEDE allocation usage accounting, and Campus Grids resource utilization. We also identify the direction of future work: improvement and expansion of Cloud accounting, persistent and elastic storage space allocation, and the incorporation of WAN and LAN network metrics.

Data Transport Subsystem - The SFOC glue

NASA Technical Reports Server (NTRS)

Parr, Stephen J.

1988-01-01

The design and operation of the Data Transport Subsystem (DTS) for the JPL Space Flight Operation Center (SFOC) are described. The SFOC is the ground data system under development to serve interplanetary space probes; in addition to the DTS, it comprises a ground interface facility, a telemetry-input subsystem, data monitor and display facilities, and a digital TV system. DTS links the other subsystems via an ISO OSI presentation layer and an LAN. Here, particular attention is given to the DTS services and service modes (virtual circuit, datagram, and broadcast), the DTS software architecture, the logical-name server, the role of the integrated AI library, and SFOC as a distributed system.

Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature.

PubMed

Hunter, Claudia M; Figueiro, Mariana G

2017-07-01

Shift work, especially that involving rotating and night shifts, is associated with an increased risk of diseases, including cancer. Attempts to explain the association between shift work and cancer in particular have focused on the processes of melatonin production and suppression. One hypothesis postulates that exposure to light at night (LAN) suppresses melatonin, whose production is known to slow the development of cancerous cells, while another proposes that circadian disruption associated with shift work, and not just LAN, increases health risks. This review focuses on six studies that employed quantitative measurement of LAN and melatonin levels to assess cancer risks in shift workers. These studies were identified via searching the PubMed database for peer-reviewed, English-language articles examining the links between shift work, LAN, and disease using the terms light at night, circadian disruption, health, risk, cancer, shift work, or rotating shift. While the results indicate a growing consensus on the relationship between disease risks (particularly cancer) and circadian disruption associated with shift work, the establishment of a direct link between LAN and disease has been impeded by contradictory studies and a lack of consistent, quantitative methods for measuring LAN in the research to date. Better protocols for assessing personal LAN exposure are required, particularly those employing calibrated devices that measure and sample exposure to workplace light conditions, to accurately assess LAN's effects on the circadian system and disease. Other methodologies, such as measuring circadian disruption and melatonin levels in the field, may also help to resolve discrepancies in the findings.

The List of Available Names (LAN): A new generation for stable taxonomic names in zoology?

PubMed

Alonso-Zarazaga, Miguel A; Fautin, Daphne Gail; Michel, Ellinor

2016-01-01

The List of Available Names in Zoology (LAN) is an inventory of names with specific scope in time and content, presented and approved in parts, and constituted as a cumulative index of names available for use in zoological nomenclature. It was defined in Article 79 in the fourth edition of the International Code of Zoological Nomenclature. The LAN is likely to gain importance with the development of the online Official Registry for Zoological Nomenclature (ZooBank) as it is potentially a source of many nomenclaturally certified names. Article 79 describes the deliberative process for adding large numbers of names to the LAN simultaneously, detailing steps and chronology for submission of a candidate Part to the LAN and consideration of a candidate Part by the public and Commission, but it is largely mute about the contents of a candidate Part. It does make clear that a name within the scope of a Part but not on the LAN has no nomenclatural standing, even if it had previously been considered available, thereby preventing long-forgotten names from displacing accepted ones and the accumulation of nomina dubia. Thus, for taxa on the LAN, nomenclatural archaeology - the resurrecting of old unused names to replace by priority names in current usage - will not be worthwhile. Beyond that, it has been unclear if Article 79 is intended to document every available name known within the scope of the Part, or if its intention is to pare the inventory of available names within the scope of the Part. Consideration by the Commission and two committees to deal with the LAN have defined steps to implement Article 79 with the latter intent. Procedures for consideration of a candidate Part are defined in a manual, published as an appendix in this volume.

A reliable multicast for XTP

NASA Technical Reports Server (NTRS)

Dempsey, Bert J.; Weaver, Alfred C.

1990-01-01

Multicast services needed for current distributed applications on LAN's fall generally into one of three categories: datagram, semi-reliable, and reliable. Transport layer multicast datagrams represent unreliable service in which the transmitting context 'fires and forgets'. XTP executes these semantics when the MULTI and NOERR mode bits are both set. Distributing sensor data and other applications in which application-level error recovery strategies are appropriate benefit from the efficiency in multidestination delivery offered by datagram service. Semi-reliable service refers to multicasting in which the control algorithms of the transport layer--error, flow, and rate control--are used in transferring the multicast distribution to the set of receiving contexts, the multicast group. The multicast defined in XTP provides semi-reliable service. Since, under a semi-reliable service, joining a multicast group means listening on the group address and entails no coordination with other members, a semi-reliable facility can be used for communication between a client and a server group as well as true peer-to-peer group communication. Resource location in a LAN is an important application domain. The term 'semi-reliable' refers to the fact that group membership changes go undetected. No attempt is made to assess the current membership of the group at any time--before, during, or after--the data transfer.

Networking the Light Fantastic--CD-ROMs on LANs.

ERIC Educational Resources Information Center

Kittle, Paul W.

1992-01-01

Describes the development of a local area network (LAN) at Loma Linda University that allows remote access for both IBM and Macintosh microcomputers to CD-ROMs. Topics discussed include types of networks; fiber optic technology; networking CD-ROM drives; remote access; modems; CD-ROM databases; memory management; interface software; and future…

Implementation of virtual LANs over ATM WANs

NASA Astrophysics Data System (ADS)

Braun, Torsten; Maehler, Martin

1998-09-01

Virtual LANs (VLANs) allow to interconnect users over campus or wide area networks and gives the users the impression as they would be connected to the same local area network (LAN). The implementation of VLANs is based on ATM Forum's LAN Emulation and LAN/ATM switches providing interconnection of emulated LANs over ATM and the LAN ports to which the user's end systems are attached to. The paper discusses possible implementation architectures and describes advanced features such as ATM short-cuts, QoS, and redundancy concepts.

ATM LAN Emulation: Getting from Here to There.

ERIC Educational Resources Information Center

Learn, Larry L., Ed.

1995-01-01

Discusses current LAN (local area network) configuration and explains ATM (asynchronous transfer mode) as the future telecommunications transport. Highlights include LAN emulation, which enables the interconnection of legacy LANs and the new ATM environment; virtual LANs; broadcast servers; and standards. (LRW)

Grid accounting service: state and future development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levshina, T.; Sehgal, C.; Bockelman, B.

2014-01-01

During the last decade, large-scale federated distributed infrastructures have been continually developed and expanded. One of the crucial components of a cyber-infrastructure is an accounting service that collects data related to resource utilization and identity of users using resources. The accounting service is important for verifying pledged resource allocation per particular groups and users, providing reports for funding agencies and resource providers, and understanding hardware provisioning requirements. It can also be used for end-to-end troubleshooting as well as billing purposes. In this work we describe Gratia, a federated accounting service jointly developed at Fermilab and Holland Computing Center at Universitymore » of Nebraska-Lincoln. The Open Science Grid, Fermilab, HCC, and several other institutions have used Gratia in production for several years. The current development activities include expanding Virtual Machines provisioning information, XSEDE allocation usage accounting, and Campus Grids resource utilization. We also identify the direction of future work: improvement and expansion of Cloud accounting, persistent and elastic storage space allocation, and the incorporation of WAN and LAN network metrics.« less

Safety management of Ethernet broadband access based on VLAN aggregation

NASA Astrophysics Data System (ADS)

Wang, Li

2004-04-01

With broadband access network development, the Ethernet technology is more and more applied access network now. It is different from the private network -LAN. The differences lie in four points: customer management, safety management, service management and count-fee management. This paper mainly discusses the safety management related questions. Safety management means that the access network must secure the customer data safety, isolate the broad message which brings the customer private information, such as ARP, DHCP, and protect key equipment from attack. Virtue LAN (VLAN) technology can restrict network broadcast flow. We can config each customer port with a VLAN, so each customer is isolated with others. The IP address bound with VLAN ID can be routed rightly. But this technology brings another question: IP address shortage. VLAN aggregation technology can solve this problem well. Such a mechanism provides several advantages over traditional IPv4 addressing architectures employed in large switched LANs today. With VLAN aggregation technology, we introduce the notion of sub-VLANs and super-VLANs, a much more optimal approach to IP addressing can be realized. This paper will expatiate the VLAN aggregation model and its implementation in Ethernet access network. It is obvious that the customers in different sub-VLANs can not communication to each other because the ARP packet is isolated. Proxy ARP can enable the communication among them. This paper will also expatiate the proxy ARP model and its implementation in Ethernet access network.

Performance Analysis of MYSEA

DTIC Science & Technology

2012-09-01

Services FSD Federated Services Daemon I&A Identification and Authentication IKE Internet Key Exchange KPI Key Performance Indicator LAN Local Area...spection takes place in different processes in the server architecture. Key Performance Indica- tor ( KPI )s associated with the system need to be...application and risk analysis of security controls. Thus, measurement of the KPIs is needed before an informed tradeoff between the performance penalties

Scalable and reusable emulator for evaluating the performance of SS7 networks

NASA Astrophysics Data System (ADS)

Lazar, Aurel A.; Tseng, Kent H.; Lim, Koon Seng; Choe, Winston

1994-04-01

A scalable and reusable emulator was designed and implemented for studying the behavior of SS7 networks. The emulator design was largely based on public domain software. It was developed on top of an environment supported by PVM, the Parallel Virtual Machine, and managed by OSIMIS-the OSI Management Information Service platform. The emulator runs on top of a commercially available ATM LAN interconnecting engineering workstations. As a case study for evaluating the emulator, the behavior of the Singapore National SS7 Network under fault and unbalanced loading conditions was investigated.

I/O performance evaluation of a Linux-based network-attached storage device

NASA Astrophysics Data System (ADS)

Sun, Zhaoyan; Dong, Yonggui; Wu, Jinglian; Jia, Huibo; Feng, Guanping

2002-09-01

In a Local Area Network (LAN), clients are permitted to access the files on high-density optical disks via a network server. But the quality of read service offered by the conventional server is not satisfied because of the multiple functions on the server and the overmuch caller. This paper develops a Linux-based Network-Attached Storage (NAS) server. The Operation System (OS), composed of an optimized kernel and a miniaturized file system, is stored in a flash memory. After initialization, the NAS device is connected into the LAN. The administrator and users could configure the access the server through the web page respectively. In order to enhance the quality of access, the management of buffer cache in file system is optimized. Some benchmark programs are peformed to evaluate the I/O performance of the NAS device. Since data recorded in optical disks are usually for reading accesses, our attention is focused on the reading throughput of the device. The experimental results indicate that the I/O performance of our NAS device is excellent.

Histochemistry of leucine aminoaphthylamidase (LAN) in rainbow trout (Salmo gairdneri)

USGS Publications Warehouse

Bouck, Gerald R.

1979-01-01

The histochemistry of leucine aminonaphthylamidase (LAN) was studied in frozen tissue sections of rainbow trout both in yearling and adult fish. Age of fish had relatively little effect upon the results. The most intense LAN color production was in epithelial cells of midgut, pyloric ceca, hindgut, and in some segments of kidney tubules. Lower levels of LAN were evident in liver cells of Kupffer, and still lower or slight levels of LAN activity were found in blood cells, muscle, nerve, connective tissue, gonad, and pancreas. The results indicate that LAN might be useful in assessing histotoxicity to LAN-rich areas of the body.

Histochemistry of leucine aminonaphthylamidase (LAN) in rainbow trout (Salmo gairdneri)

USGS Publications Warehouse

Bouck, Gerald R.

1979-01-01

The histochemistry of leucine aminonaphthylamidase (LAN) was studied in frozen tissue sections of rainbow trout both in yearling and adult fish. Age of fish had relatively little effect upon the results. The most intense LAN color production was in epithelial cells of midgut, pyloric ceca, hindgut, and in some segments of kidney tubules. Lower levels of LAN were evident in liver cells of Kupffer, and still lower or slight levels of LAN activity were found in blood cells, muscle, nerve, connective tissue, gonad, and pancreas. The results indicate that LAN might be useful in assessing histotoxicity to LAN-rich areas of the body.

Network Monitoring in the age of the Cloud

NASA Astrophysics Data System (ADS)

Ciuffoletti, Augusto

Network virtualization plays a relevant role in provisioning an Infrastructure as a Service (IaaS), implementing the fabric that interconnects virtual components. We identify the standard protocol IEEE802.1Q, that describes Virtual LAN (VLAN) functionalities, as a cornerstone in this architecture.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Intrator, Miranda Huang

Los Alamos National Security, LLC (LANS) is the manager and operator of Los Alamos National Laboratory (Los Alamos) for the U.S. Department of Energy National Nuclear Security Administration under contract DE-AC52- 06NA25396. Los Alamos is a mission-centric Federally Funded Research and Development Center focused on solving critical national security challenges through science and engineering for both government and private customers. LANS is opening this formal Request for Information (RFI) to gauge interest in engaging as an industry partner to LANS for collaboration in advancing the bio-assessment platform described below. Please see last section for details on submitting a Letter ofmore » Interest.« less

Internet-based transfusion audit system

NASA Astrophysics Data System (ADS)

Maitan, Jacek; Haley, Rebecca

1995-03-01

This project is aimed at developing a cost-effective working environment for the transfusion medicine specialists of American Red Cross (ARC). In this project we are developing a multimedia-based consultation environment that uses Internet and teleconferencing to increase the quality of services and to replace currently used 800 telephone lines. Through the use of Internet/LAN/ISDN the physicians can share information and references while they discuss patient cases. A multimedia interface allows the physician to access data from the office and from the house. This paper discusses the approach, current status of the project and future plans to extend the approach to other areas of medicine.

Veterinary Laboratory Services Study - 1976.

DTIC Science & Technology

1976-09-01

rabies , equine infectious anemia and other zoonotic and animal dis— eases has actually increased or increase in this area is p lanned. Some special...functions were transferred to the Department of Chemistry in October 1975. A sheep flock is main- tained and sheep blood is supplied to clinical...since several dv~guostic procedures involving zoonotic diseases are done there. Their ciagnostic service could be considered a prototype for other Medical

LAN MAP: An Innovative Airborne Light at Night Mapping Project

NASA Astrophysics Data System (ADS)

Craine, Eric R.; Craine, B. L.; Craine, E. M.; Craine, P. R.

2013-01-01

Widespread installation of inefficient and misdirected artificial light at night (LAN) has led to increasing concerns about light pollution and its impact, not only on astronomical facilities but larger communities as well. Light pollution impacts scientific research, environmental ecosystems, human health, and quality of life. In recent years, the public policy response to light pollution has included formulation of government codes to regulate lighting design and installation. Various environmental groups now include light pollution among their rallying themes to protest both specific and general developments. The latter efforts are often conducted in the absence of any quantitative data and are frequently charged by emotion rather than reason. To bring some scientific objectivity, and quantitative data, to these discussions, we have developed a suite of tools for simultaneous photometric measurements and temporal monitoring of both local communities and the sky overhead. We have also developed novel protocols for the use of these tools, including a triad of airborne, ground mobile, and ground static photometric surveys. We present a summary of these tools and protocols, with special emphasis on the airborne systems, and discuss baseline and follow-up measurements of LAN environments in the vicinity of numerous observatories in Arizona, the home of the initial LAN MAP surveys.

Wireless Command-and-Control of UAV-Based Imaging LANs

NASA Technical Reports Server (NTRS)

Herwitz, Stanley; Dunagan, S. E.; Sullivan, D. V.; Slye, R. E.; Leung, J. G.; Johnson, L. F.

2006-01-01

Dual airborne imaging system networks were operated using a wireless line-of-sight telemetry system developed as part of a 2002 unmanned aerial vehicle (UAV) imaging mission over the USA s largest coffee plantation on the Hawaiian island of Kauai. A primary mission objective was the evaluation of commercial-off-the-shelf (COTS) 802.11b wireless technology for reduction of payload telemetry costs associated with UAV remote sensing missions. Predeployment tests with a conventional aircraft demonstrated successful wireless broadband connectivity between a rapidly moving airborne imaging local area network (LAN) and a fixed ground station LAN. Subsequently, two separate LANs with imaging payloads, packaged in exterior-mounted pressure pods attached to the underwing of NASA's Pathfinder-Plus UAV, were operated wirelessly by ground-based LANs over independent Ethernet bridges. Digital images were downlinked from the solar-powered aircraft at data rates of 2-6 megabits per second (Mbps) over a range of 6.5 9.5 km. An integrated wide area network enabled payload monitoring and control through the Internet from a range of ca. 4000 km during parts of the mission. The recent advent of 802.11g technology is expected to boost the system data rate by about a factor of five.

JPRS Report, Soviet Union, Political Affairs.

DTIC Science & Technology

1988-12-06

bilingual and trilingual national literatures (Belgian, Swiss...) which testify to the fact that the people themselves are heterogeneous in their lan...Schools were opened and commercial and medical JPRS-UPA-88-056 06 December 1988 37 REGIONAL ISSUES services were improved. At the borderline of the

Depressive-like behavior is elevated among offspring of parents exposed to dim light at night prior to mating.

PubMed

Cissé, Yasmine M; Russart, Kathryn L G; Nelson, Randy J

2017-09-01

Rates of major depressive disorder (MDD) have steadily increased over the past 50 years. Many factors have been implicated in the etiology of depressive disorders and environmental influences are being increasingly recognized. The increase in depression rates has coincided with increased artificial nighttime lighting. Exposure to light at night (LAN) has been associated with increased depressive-like behavior in rodents and decreased mood in humans. However, relatively little is known on the multigenerational effects of dLAN on affect. In this study, we exposed adult male and female Siberian hamsters (Phodopus sungorus) to either DARK (0lx) or dim LAN (5lx) for 9 weeks, then paired animals in a full factorial design; all animals were thereafter housed in dark nights. Offspring were gestated and reared in dark nights, then tested in adulthood for depressive-like behaviors and hippocampal expression of glucocorticoid (GR) and melatonin (MT1) receptor expression. Maternal exposure to dLAN decreased sucrose preference, time to first float bout in the Porsolt swim test, and GR expression in the hippocampus. Paternal exposure to dLAN increased time spent floating, and increased hippocampal GR expression. Overall, our results suggest that chronic exposure of parents to light at night has multigenerational effects on offspring depressive-like behavior. If these results pertain to humans, then our data suggest that LAN may contribute to the rapidly rising rates of major depressive disorder in industrialized and developing countries. Copyright © 2017 Elsevier Ltd. All rights reserved.

An overview of SAFENET and its implications for aerospace applications

NASA Technical Reports Server (NTRS)

Collins, George C.; Bown, Rodney L.

1991-01-01

The survivable, adaptable fiber optic embeddable network (SAFENET) is a draft standard for local area networking (LAN) developed by the Navy which, when adopted, will become a military standard. The standard is being developed for procurement specifications of computer resources to be used on ships and aircraft and has some of the real-time concerns that network standards for space vehicles have. Architecture and survivability are considered. It is noted that the token-ring LAN must implement the IEEE 802.5 recommended practice for dual ring reconfiguration, which is currently being reviewed for inclusion into the IEEE standard. A trunk coupling unit is used at each station to isolate a station from the ring in case of failure. Up to five stations can be bypassed in this fashion. Communication architecture has an OSI profile but differs from the standard concept of the seven layers by allowing alternate suits and breaking the layers into three groupings of services to allow for physical interfacing. It also provides several paths, even if only one profile is used. Management and synchronization protocols are discussed and security issues are addressed. Implications for aerospace applications are considered and it is projected that interoperability with the Navy and other U.S. Government systems may require SAFENET specifications for NASA systems.

Los Alamos National Security, LLC Request for Information from industrial entities that desire to commercialize Laboratory-developed Extremely Low Resource Optical Identifier (ELROI) tech

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, Michael Charles

Los Alamos National Security, LLC (LANS) is the manager and operator of the Los Alamos National Laboratory for the U.S. Department of Energy National Nuclear Security Administration under contract DE-AC52-06NA25396. LANS is a mission-centric Federally Funded Research and Development Center focused on solving the most critical national security challenges through science and engineering for both government and private customers.

Quality of Service Control Based on Virtual Private Network Services in a Wide Area Gigabit Ethernet Optical Test Bed

NASA Astrophysics Data System (ADS)

Rea, Luca; Pompei, Sergio; Valenti, Alessandro; Matera, Francesco; Zema, Cristiano; Settembre, Marina

We report an experimental investigation about the Virtual Private LAN Service technique to guarantee the quality of service in the metro/core network and also in the presence of access bandwidth bottleneck. We also show how the virtual private network can be set up for answering to a user request in a very fast way. The tests were performed in a GMPLS test bed with GbE core routers linked with long (tens of kilometers) GbE G.652 fiber links.

Bringing the medical library to the office desktop.

PubMed

Brown, S R; Decker, G; Pletzke, C J

1991-01-01

This demonstration illustrates LRC Remote Computer Services- a dual operating system, multi-protocol system for delivering medical library services to the medical professional's desktop. A working model draws resources from CD-ROM and magnetic media file services, Novell and AppleTalk network protocol suites and gating, LAN and asynchronous (dial-in) access strategies, commercial applications for MS-DOS and Macintosh workstations and custom user interfaces. The demonstration includes a discussion of issues relevant to the delivery of said services, particularly with respect to maintenance, security, training/support, staffing, software licensing and costs.

System analysis for the Huntsville Operation Support Center distributed computer system

NASA Technical Reports Server (NTRS)

Ingels, F. M.

1986-01-01

A simulation model of the NASA Huntsville Operational Support Center (HOSC) was developed. This simulation model emulates the HYPERchannel Local Area Network (LAN) that ties together the various computers of HOSC. The HOSC system is a large installation of mainframe computers such as the Perkin Elmer 3200 series and the Dec VAX series. A series of six simulation exercises of the HOSC model is described using data sets provided by NASA. The analytical analysis of the ETHERNET LAN and the video terminals (VTs) distribution system are presented. An interface analysis of the smart terminal network model which allows the data flow requirements due to VTs on the ETHERNET LAN to be estimated, is presented.

Use of Optical Storage Devices as Shared Resources in Local Area Networks

DTIC Science & Technology

1989-09-01

13 3. SERVICE CALLS FOR MS-DOS CD-ROM EXTENSIONS . 14 4. MS-DOS PRIMITIVE GROUPS ....................... 15 5. RAM USAGE FOR VARIOUS LAN...17 2. Service Call Translation to DOS Primitives ............. 19 3. MS-DOS Device Drivers ............................. 21 4. MS-DOS/ROM...directed to I/O devices will be referred to as primitive instruction groups). These primitive instruction groups include keyboard, video, disk, serial

Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats.

PubMed

Opperhuizen, Anne-Loes; Stenvers, Dirk J; Jansen, Remi D; Foppen, Ewout; Fliers, Eric; Kalsbeek, Andries

2017-07-01

Exposure to light at night (LAN) has increased dramatically in recent decades. Animal studies have shown that chronic dim LAN induced obesity and glucose intolerance. Furthermore, several studies in humans have demonstrated that chronic exposure to artificial LAN may have adverse health effects with an increased risk of metabolic disorders, including type 2 diabetes. It is well-known that acute exposure to LAN affects biological clock function, hormone secretion and the activity of the autonomic nervous system, but data on the effects of LAN on glucose homeostasis are lacking. This study aimed to investigate the acute effects of LAN on glucose metabolism. Male Wistar rats were subjected to i.v. glucose or insulin tolerance tests while exposed to 2 h of LAN in the early or late dark phase. In subsequent experiments, different light intensities and wavelengths were used. LAN exposure early in the dark phase at ZT15 caused increased glucose responses during the first 20 min after glucose infusion (p < 0.001), whereas LAN exposure at the end of the dark phase, at ZT21, caused increased insulin responses during the first 10 min (p < 0.01), indicating that LAN immediately induces glucose intolerance in rats. Subsequent experiments demonstrated that the effect of LAN was both intensity- and wavelength-dependent. White light of 50 and 150 lx induced greater glucose responses than 5 and 20 lx, whereas all intensities other than 5 lx reduced locomotor activity. Green light induced glucose intolerance, but red and blue light did not, suggesting the involvement of a specific retina-brain pathway. Together, these data show that exposure to LAN has acute adverse effects on glucose metabolism in a time-, intensity- and wavelength-dependent manner.

Local Area Networks.

ERIC Educational Resources Information Center

Nasatir, Marilyn; And Others

1990-01-01

Four papers discuss LANs (local area networks) and library applications: (1) "Institute for Electrical and Electronic Engineers Standards..." (Charles D. Brown); (2) "Facilities Planning for LANs..." (Gail Persky); (3) "Growing up with the Alumni Library: LAN..." (Russell Buchanan); and (4) "Implementing a LAN...at the Health Sciences Library"…

Development Of Fiber Optics For Passenger Car Applications

NASA Astrophysics Data System (ADS)

Steele, R. E.; Schmitt, H. J.

1987-12-01

The benefits of fiber optics for telecommunications and Local Area Networks (LANs) are well documented. The benefits to passenger car applications are not as clearly defined. This paper examines the differences between Telecommunications, LAN, and automotive point to point and network applications. Current production automotive applications of optics and fiber optics, automotive data communications trends, and both functional and non-functional requirements and constraints will be described.

Video and LAN solutions for a digital OR: the Varese experience

NASA Astrophysics Data System (ADS)

Nocco, Umberto; Cocozza, Eugenio; Sivo, Monica; Peta, Giancarlo

2007-03-01

Purpose: build 20 ORs equipped with independent video acquisition and broadcasting systems and a powerful LAN connectivity. Methods: a digital PC controlled video matrix has been installed in each OR. The LAN connectivity has been developed to grant data entering the OR and high speed connectivity to a server and to broadcasting devices. Video signals are broadcasted within the OR. Fixed inputs and five additional video inputs have been placed in the OR. Images can be stored locally on a high capacity HDD and a DVD recorder. Images can be also stored in a central archive for future acquisition and reference. Ethernet plugs have been placed within the OR to acquire images and data from the Hospital LAN; the OR is connected to the server/archive using a dedicated optical fiber. Results: 20 independent digital ORs have been built. Each OR is "self contained" and images can be digitally managed and broadcasted. Security issues concerning both image visualization and electrical safety have been fulfilled and each OR is fully integrated in the Hospital LAN. Conclusions: Digital ORs were fully implemented, they fulfill surgeons needs in terms of video acquisition and distribution and grant high quality video for each kind of surgery in a major hospital.

Dim Light at Night Prior to Adolescence Increases Adult Anxiety-like Behaviors

PubMed Central

Cissé, Yasmine M.; Peng, Juan; Nelson, Randy J.

2017-01-01

Dim light at night (dLAN) disrupts circadian organization and influences adult behavior. We examined early dLAN exposure on adult affective responses. Beginning 3 (juvenile) or 5 weeks (adolescent) of age, mice were maintained in standard light-dark cycles or exposed to nightly dLAN (5 lux) for 5 weeks, then anxiety-like and fear responses were assessed. Hypothalami were collected around the clock to assess core clock genes. Exposure to dLAN at either age increased anxiety-like responses in adults. Clock and Rev-ERB expression were altered by exposure to dLAN. In contrast to adults, dLAN exposure during early life increases anxiety and fear behavior. PMID:27592634

Dim light at night prior to adolescence increases adult anxiety-like behaviors.

PubMed

Cissé, Yasmine M; Peng, Juan; Nelson, Randy J

2016-01-01

Dim light at night (dLAN) disrupts circadian organization and influences adult behavior. We examined early dLAN exposure on adult affective responses. Beginning 3 (juvenile) or 5 weeks (adolescent) of age, mice were maintained in standard light-dark cycles or exposed to nightly dLAN (5 lx) for 5 weeks, then anxiety-like and fear responses were assessed. Hypothalami were collected around the clock to assess core clock genes. Exposure to dLAN at either age increased anxiety-like responses in adults. Clock and Rev-ERB expression were altered by exposure to dLAN. In contrast to adults, dLAN exposure during early life increases anxiety and fear behavior.

Design, Implementation, and Verification of the Reliable Multicast Protocol. Thesis

NASA Technical Reports Server (NTRS)

Montgomery, Todd L.

1995-01-01

This document describes the Reliable Multicast Protocol (RMP) design, first implementation, and formal verification. RMP provides a totally ordered, reliable, atomic multicast service on top of an unreliable multicast datagram service. RMP is fully and symmetrically distributed so that no site bears an undue portion of the communications load. RMP provides a wide range of guarantees, from unreliable delivery to totally ordered delivery, to K-resilient, majority resilient, and totally resilient atomic delivery. These guarantees are selectable on a per message basis. RMP provides many communication options, including virtual synchrony, a publisher/subscriber model of message delivery, a client/server model of delivery, mutually exclusive handlers for messages, and mutually exclusive locks. It has been commonly believed that total ordering of messages can only be achieved at great performance expense. RMP discounts this. The first implementation of RMP has been shown to provide high throughput performance on Local Area Networks (LAN). For two or more destinations a single LAN, RMP provides higher throughput than any other protocol that does not use multicast or broadcast technology. The design, implementation, and verification activities of RMP have occurred concurrently. This has allowed the verification to maintain a high fidelity between design model, implementation model, and the verification model. The restrictions of implementation have influenced the design earlier than in normal sequential approaches. The protocol as a whole has matured smoother by the inclusion of several different perspectives into the product development.

Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity.

PubMed

Cissé, Yasmine M; Russart, Kathryn L G; Nelson, Randy J

2017-03-31

Exposure to dim light at night (dLAN) disrupts natural light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biological function, including the endocrine and immune systems. We have previously demonstrated that white dLAN compromises innate and cell mediated immune responses in adult Siberian hamsters (Phodopus sungorus). We hypothesized that dLAN has transgenerational influences on immune function. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 9 weeks, then paired in full factorial design, mated, and thereafter housed under dark nights. Offspring were gestated and reared in dark nights, then tested as adults for cell-mediated and humoral immunity. Maternal exposure to dLAN dampened delayed type hypersensitivity (DTH) responses in male offspring. Maternal and paternal exposure to dLAN reduced DTH responses in female offspring. IgG antibodies to a novel antigen were elevated in offspring of dams exposed to dLAN. Paternal exposure to dLAN decreased splenic endocrine receptor expression and global methylation in a parental sex-specific manner. Together, these data suggest that exposure to dLAN has transgenerational effects on endocrine-immune function that may be mediated by global alterations in the epigenetic landscape of immune tissues.

Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity

PubMed Central

Cissé, Yasmine M.; Russart, Kathryn L.G.; Nelson, Randy J.

2017-01-01

Exposure to dim light at night (dLAN) disrupts natural light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biological function, including the endocrine and immune systems. We have previously demonstrated that white dLAN compromises innate and cell mediated immune responses in adult Siberian hamsters (Phodopus sungorus). We hypothesized that dLAN has transgenerational influences on immune function. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 9 weeks, then paired in full factorial design, mated, and thereafter housed under dark nights. Offspring were gestated and reared in dark nights, then tested as adults for cell-mediated and humoral immunity. Maternal exposure to dLAN dampened delayed type hypersensitivity (DTH) responses in male offspring. Maternal and paternal exposure to dLAN reduced DTH responses in female offspring. IgG antibodies to a novel antigen were elevated in offspring of dams exposed to dLAN. Paternal exposure to dLAN decreased splenic endocrine receptor expression and global methylation in a parental sex-specific manner. Together, these data suggest that exposure to dLAN has transgenerational effects on endocrine-immune function that may be mediated by global alterations in the epigenetic landscape of immune tissues. PMID:28361901

High Speed Computing, LANs, and WAMs

NASA Technical Reports Server (NTRS)

Bergman, Larry A.; Monacos, Steve

1994-01-01

Optical fiber networks may one day offer potential capacities exceeding 10 terabits/sec. This paper describes present gigabit network techniques for distributed computing as illustrated by the CASA gigabit testbed, and then explores future all-optic network architectures that offer increased capacity, more optimized level of service for a given application, high fault tolerance, and dynamic reconfigurability.

Exposure to dim light at night during early development increases adult anxiety-like responses.

PubMed

Borniger, Jeremy C; McHenry, Zachary D; Abi Salloum, Bachir A; Nelson, Randy J

2014-06-22

Early experiences produce effects that may persist throughout life. Therefore, to understand adult phenotype, it is important to investigate the role of early environmental stimuli in adult behavior and health. Artificial light at night (LAN) is an increasingly common phenomenon throughout the world. However, animals, including humans, evolved under dark night conditions. Many studies have revealed affective, immune, and metabolic alterations provoked by aberrant light exposure and subsequent circadian disruption. Pups are receptive to entraining cues from the mother and then light early during development, raising the possibility that the early life light environment may influence subsequent behavior. Thus, to investigate potential influences of early life exposure to LAN on adult phenotype, we exposed mice to dim (~5 lux; full spectrum white light) or dark (~0 lux) nights pre- and/or postnatally. After weaning at 3 weeks of age, all mice were maintained in dark nights until adulthood (9 weeks of age) when behavior was assessed. Mice exposed to dim light in early life increased anxiety-like behavior and fearful responses on the elevated plus maze and passive avoidance tests. These mice also displayed reduced growth rates, which ultimately normalized during adolescence. mRNA expression of brain derived neurotrophic factor (BDNF), a neurotrophin previously linked to early life environment and adult phenotype, was not altered in the prefrontal cortex or hippocampus by early life LAN exposure. Serum corticosterone concentrations were similar between groups at weaning, suggesting that early life LAN does not elicit a long-term physiologic stress response. Dim light exposure did not influence behavior on the open field, novel object, sucrose anhedonia, or forced swim tests. Our data highlight the potential deleterious consequences of low levels of light during early life to development and subsequent behavior. Whether these changes are due to altered maternal behavior or persistent circadian abnormalities incurred by LAN remains to be determined. Copyright © 2014 Elsevier Inc. All rights reserved.

Development and Implementation of Kumamoto Technopolis Regional Database T-KIND

NASA Astrophysics Data System (ADS)

Onoue, Noriaki

T-KIND (Techno-Kumamoto Information Network for Data-Base) is a system for effectively searching information of technology, human resources and industries which are necessary to realize Kumamoto Technopolis. It is composed of coded database, image database and LAN inside technoresearch park which is the center of R & D in the Technopolis. It constructs on-line system by networking general-purposed computers, minicomputers, optical disk file systems and so on, and provides the service through public telephone line. Two databases are now available on enterprise information and human resource information. The former covers about 4,000 enterprises, and the latter does about 2,000 persons.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lepine, Sebastien; Bergeron, P.; Lanning, Howard H., E-mail: lepine@amnh.org

We present spectroscopic observations confirming the identification of hot white dwarfs among UV-bright sources from the Sandage Two-color Survey of the Galactic Plane and listed in the Lanning (Lan) catalog of such sources. A subsample of 213 UV-bright Lan sources have been identified as candidate white dwarfs based on the detection of a significant proper motion. Spectroscopic observations of 46 candidates with the KPNO 2.1 m telescope confirm 30 sources to be hydrogen white dwarfs with subtypes in the DA1-DA6 range, and with one of the stars (Lan 161) having an unresolved M dwarf as a companion. Five more sourcesmore » are confirmed to be helium white dwarfs, with subtypes from DB3 to DB6. One source (Lan 364) is identified as a DZ 3 white dwarf, with strong lines of calcium. Three more stars are found to have featureless spectra (to within detection limits) and are thus classified as DC white dwarfs. In addition, three sources are found to be hot subdwarfs: Lan 20 and Lan 480 are classified as sdOB, and Lan 432 is classified sdB. The remaining four objects are found to be field F star interlopers. Physical parameters of the DA and DB white dwarfs are derived from model fits.« less

2005 8th Annual Systems Engineering Conference Volume 3 - Wednesday presentations

DTIC Science & Technology

2005-10-24

phasi s on s ystem s eng ineeri ng Imple menta tion o f SE P lans Requires PEO chief engineer Conduct of technical reviews SE Policy Addendum Signed by...in a Performance Based Logistics Environment, Denise Duncan, LMI Track 5 - Best Practices & Standardization: CMMI for Services, Mr. Juan Ceva...CMMI for Services Mr. Juan Ceva, Raytheon RIS TRACK 5 Logistics Session 3C5 TRACK 4 Net Centric Operations Session 3C4 TRACK 6 Modeling & Simulation

Enhanced International Space Station Ku-Band Telemetry Service

NASA Technical Reports Server (NTRS)

Cecil, Andrew; Pitts, Lee; Welch, Steven; Bryan, Jason

2014-01-01

(1) The ISS is diligently working to increase utilization of the resources this unique laboratory provides; (2) Recent upgrades enabled the use of Internet Protocol communication using the CCSDS IP Encapsulation protocol; and (3) The Huntsville Operations Support Center has extended the onboard LAN to payload teams enabling the use of standard IP protocols for payload operations.

Wireless local area networking for linking a PC reporting system and PACS: clinical feasibility in emergency reporting.

PubMed

Yoshihiro, Akiko; Nakata, Norio; Harada, Junta; Tada, Shimpei

2002-01-01

Although local area networks (LANs) are commonplace in hospital-based radiology departments today, wireless LANs are still relatively unknown and untried. A linked wireless reporting system was developed to improve work throughput and efficiency. It allows radiologists, physicians, and technologists to review current radiology reports and images and instantly compare them with reports and images from previous examinations. This reporting system also facilitates creation of teaching files quickly, easily, and accurately. It consists of a Digital Imaging and Communications in Medicine 3.0-based picture archiving and communication system (PACS), a diagnostic report server, and portable laptop computers. The PACS interfaces with magnetic resonance imagers, computed tomographic scanners, and computed radiography equipment. The same kind of functionality is achievable with a wireless LAN as with a wired LAN, with comparable bandwidth but with less cabling infrastructure required. This wireless system is presently incorporated into the operations of the emergency and radiology departments, with future plans calling for applications in operating rooms, outpatient departments, all hospital wards, and intensive care units. No major problems have been encountered with the system, which is in constant use and appears to be quite successful. Copyright RSNA, 2002

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses.

PubMed

Aubrecht, Taryn G; Weil, Zachary M; Magalang, Ulysses J; Nelson, Randy J

2013-07-01

Obstructive sleep apnea (OSA) and dim light at night (dLAN) have both been independently associated with alterations in mood and cognition. We aimed to determine whether dLAN would interact with intermittent hypoxia (IH), a condition characteristic of OSA, to alter the behavioral, cognitive, and affective responses. Adult male mice were housed in either standard lighting conditions (14:10-h light-dark cycle; 150 lux:0 lux) or dLAN (150 lux:5 lux). Mice were then exposed to IH (15 cycles/h, 8 h/day, FiO2 nadir of 5%) for 3 wk, then tested in assays of affective and cognitive responses; brains were collected for dendritic morphology and PCR analysis. Exposure to dLAN and IH increased anxiety-like behaviors, as assessed in the open field, elevated plus maze, and the light/dark box. dLAN and IH increased depressive-like behaviors in the forced swim test. IH impaired learning and memory performance in the passive avoidance task; however, no differences were observed in spatial working memory, as assessed by y-maze or object recognition. IH combined with dLAN decreased cell body area in the CA1 and CA3 regions of the hippocampus. Overall, IH decreased apical spine density in the CA3, whereas dLAN decreased spine density in the CA1 of the hippocampus. TNF-α gene expression was not altered by IH or lighting condition, whereas VEGF expression was increased by dLAN. The combination of IH and dLAN provokes negative effects on hippocampal dendritic morphology, affect, and cognition, suggesting that limiting nighttime exposure to light in combination with other established treatments may be of benefit to patients with OSA.

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

PubMed Central

Weil, Zachary M.; Magalang, Ulysses J.; Nelson, Randy J.

2013-01-01

Obstructive sleep apnea (OSA) and dim light at night (dLAN) have both been independently associated with alterations in mood and cognition. We aimed to determine whether dLAN would interact with intermittent hypoxia (IH), a condition characteristic of OSA, to alter the behavioral, cognitive, and affective responses. Adult male mice were housed in either standard lighting conditions (14:10-h light-dark cycle; 150 lux:0 lux) or dLAN (150 lux:5 lux). Mice were then exposed to IH (15 cycles/h, 8 h/day, FiO2 nadir of 5%) for 3 wk, then tested in assays of affective and cognitive responses; brains were collected for dendritic morphology and PCR analysis. Exposure to dLAN and IH increased anxiety-like behaviors, as assessed in the open field, elevated plus maze, and the light/dark box. dLAN and IH increased depressive-like behaviors in the forced swim test. IH impaired learning and memory performance in the passive avoidance task; however, no differences were observed in spatial working memory, as assessed by y-maze or object recognition. IH combined with dLAN decreased cell body area in the CA1 and CA3 regions of the hippocampus. Overall, IH decreased apical spine density in the CA3, whereas dLAN decreased spine density in the CA1 of the hippocampus. TNF-α gene expression was not altered by IH or lighting condition, whereas VEGF expression was increased by dLAN. The combination of IH and dLAN provokes negative effects on hippocampal dendritic morphology, affect, and cognition, suggesting that limiting nighttime exposure to light in combination with other established treatments may be of benefit to patients with OSA. PMID:23657638

Bandwidth Management in Resource Constrained Networks

DTIC Science & Technology

2012-03-01

Postgraduate School OSI Open Systems Interconnection QoS Quality of Service TCP Transmission Control Protocol/Internet Protocol TCP/IP Transmission...filtering. B. NORMAL TCP/IP COMMUNICATIONS The Internet is a “complex network WAN that connects LANs and clients around the globe” (Dean, 2009...of the Open Systems Interconnection ( OSI ) model allowing them to route traffic based on MAC address (Kurose & Ross, 2009). While switching

Listen up, eye movements play a role in verbal memory retrieval.

PubMed

Scholz, Agnes; Mehlhorn, Katja; Krems, Josef F

2016-01-01

People fixate on blank spaces if visual stimuli previously occupied these regions of space. This so-called "looking at nothing" (LAN) phenomenon is said to be a part of information retrieval from internal memory representations, but the exact nature of the relationship between LAN and memory retrieval is unclear. While evidence exists for an influence of LAN on memory retrieval for visuospatial stimuli, evidence for verbal information is mixed. Here, we tested the relationship between LAN behavior and memory retrieval in an episodic retrieval task where verbal information was presented auditorily during encoding. When participants were allowed to gaze freely during subsequent memory retrieval, LAN occurred, and it was stronger for correct than for incorrect responses. When eye movements were manipulated during memory retrieval, retrieval performance was higher when participants fixated on the area associated with to-be-retrieved information than when fixating on another area. Our results provide evidence for a functional relationship between LAN and memory retrieval that extends to verbal information.

Lanreotide autogel every 6 weeks compared with Lanreotide microparticles every 3 weeks in patients with well differentiated neuroendocrine tumors: a Phase III Study.

PubMed

Bajetta, Emilio; Procopio, Giuseppe; Catena, Laura; Martinetti, Antonia; De Dosso, Sara; Ricci, Sergio; Lecchi, Alberto S; Boscani, Paolo F; Iacobelli, Stefano; Carteni, Giacomo; De Braud, Filippo; Loli, Paola; Tartaglia, Andreas; Bajetta, Roberto; Ferrari, Leonardo

2006-11-15

The noninferiority of a 6-week dosing schedule of lanreotide Autogel (Lan ATG) at a dose of 120 mg compared with a 3-week dosing schedule of lanreotide microparticles (Lan MP) at a dose of 60 mg was investigated in patients with neuroendocrine tumors (NET). Patients who had sporadic, well differentiated NET with a low grade of malignancy were recruited for this open-label, Phase III, multicenter trial. Patients were randomized to receive either 3 deep subcutaneous injections of Lan ATG (120 mg, every 6 weeks) or 6 intramuscular injections of Lan MP (60 mg, every 3 weeks). Tumor markers, tumor size, and symptoms were assessed between baseline and Week 18. Success was classified as a response that ranged from disappearance to an increase <25% in tumor marker, tumor size, or symptom frequency. Sixty patients were randomized, and 46 patients completed the study. Both for tumor markers and for tumor size, Lan ATG was not inferior to Lan MP (55% and 59% of patients responded on tumor markers, respectively; 68% and 66% of patients responded on tumor size, respectively). There were too few symptomatic patients to compare carcinoid symptoms. Both treatments were tolerated well, and no safety concerns were identified. Lan ATG at a dose of 120 mg every 6 weeks was as effective for controlling NET as Lan MP at a dose of 60 mg every 3 weeks.

Multi-Protocol LAN Design and Implementation: A Case Study.

ERIC Educational Resources Information Center

Hazari, Sunil

1995-01-01

Reports on the installation of a local area network (LAN) at East Carolina University. Topics include designing the network; computer labs and electronic mail; Internet connectivity; LAN expenses; and recommendations on planning, equipment, administration, and training. A glossary of networking terms is also provided. (AEF)

The Construction of Infrastructure for Library's Digital Document Telecommunications.

ERIC Educational Resources Information Center

Changxing, Ying; Zuzao, Lin

This paper discusses the construction of the infrastructure for libraries' digital document telecommunications. The first section describes the topologies of the library LAN (Local Area Network) cabling system, including the main characteristics of the LAN and three classical topologies typically used with LANs, i.e., the bus, star, and ring…

Exercise attenuates the metabolic effects of dim light at night.

PubMed

Fonken, Laura K; Meléndez-Fernández, O Hecmarie; Weil, Zachary M; Nelson, Randy J

2014-01-30

Most organisms display circadian rhythms that coordinate complex physiological and behavioral processes to optimize energy acquisition, storage, and expenditure. Disruptions to the circadian system with environmental manipulations such as nighttime light exposure alter metabolic energy homeostasis. Exercise is known to strengthen circadian rhythms and to prevent weight gain. Therefore, we hypothesized providing mice a running wheel for voluntary exercise would buffer against the effects of light at night (LAN) on weight gain. Mice were maintained in either dark (LD) or dim (dLAN) nights and provided either a running wheel or a locked wheel. Mice exposed to dim, rather than dark, nights increased weight gain. Access to a functional running wheel prevented body mass gain in mice exposed to dLAN. Voluntary exercise appeared to limit weight gain independently of rescuing changes to the circadian system caused by dLAN; increases in daytime food intake induced by dLAN were not diminished by increased voluntary exercise. Furthermore, although all of the LD mice displayed a 24h rhythm in wheel running, nearly half (4 out of 9) of the dLAN mice did not display a dominant 24h rhythm in wheel running. These results indicate that voluntary exercise can prevent weight gain induced by dLAN without rescuing circadian rhythm disruptions. © 2013.

Supporting Command and Control (C2) of an Embarked Commander: Tunneling SIPRNet Data Across an UNCLAS Wireless LAN

DTIC Science & Technology

2011-09-01

that you did to help me through this process. Your efforts and guidance truly made this a success. To SPAWAR SCTD expert Stephanie Koontz , your...ty%20and%20Safety%20Services/05– 500%20Security%20Services/5510.36A.pdf [accessed June 19, 2011]. [28] S. Koontz . “Secret client tunneling...devices - KOV-26 talon user procedures.” Unpublished survey, SPAWAR, Point Loma, CA. [29] S. Koontz . “Secret client tunneling devices - KIV-54 user

Information infrastructure for emergency medical services.

PubMed

Orthner, Helmuth; Mishra, Ninad; Terndrup, Thomas; Acker, Joseph; Grimes, Gary; Gemmill, Jill; Battles, Marcie

2005-01-01

The pre-hospital emergency medical and public safety information environment is nearing a threshold of significant change. The change is driven in part by several emerging technologies such as secure, high-speed wireless communication in the local and wide area networks (wLAN, 3G), Geographic Information Systems (GIS), Global Positioning Systems (GPS), and powerful handheld computing and communication services, that are of sufficient utility to be more widely adopted. We propose a conceptual model to enable improved clinical decision making in the pre-hospital environment using these change agents.

Temporal variation and source identification of black carbon at Lin'an and Longfengshan regional background stations in China

NASA Astrophysics Data System (ADS)

Cheng, Siyang; Wang, Yaqiang; An, Xingqin

2017-12-01

Black carbon (BC) is a component of fine particulate matter (PM2.5), associated with climate, weather, air quality, and people's health. However, studies on temporal variation of atmospheric BC concentration at background stations in China and its source area identification are lacking. In this paper, we use 2-yr BC observations from two background stations, Lin'an (LAN) and Longfengshan (LFS), to perform the investigation. The results show that the mean diurnal variation of BC has two significant peaks at LAN while different characteristics are found in the BC variation at LFS, which are probably caused by the difference in emission source contributions. Seasonal variation of monthly BC shows double peaks at LAN but a single peak at LFS. The annual mean concentrations of BC at LAN and LFS decrease by 1.63 and 0.26 μg m-3 from 2009 to 2010, respectively. The annual background concentration of BC at LAN is twice higher than that at LFS. The major source of the LAN BC is industrial emission while the source of the LFS BC is residential emission. Based on transport climatology on a 7-day timescale, LAN and LFS stations are sensitive to surface emissions respectively in belt or approximately circular area, which are dominated by summer monsoon or colder land air flows in Northwest China. In addition, we statistically analyze the BC source regions by using BC observation and FLEXible PARTicle dispersion model (FLEXPART) simulation. In summer, the source regions of BC are distributed in the northwest and south of LAN and the southwest of LFS. Low BC concentration is closely related to air mass from the sea. In winter, the source regions of BC are concentrated in the west and south of LAN and the northeast of the threshold area of s tot at LFS. The cold air mass in the northwest plays an important role in the purification of atmospheric BC. On a yearly scale, sources of BC are approximately from five provinces in the northwest/southeast of LAN and the west of LFS. These findings are helpful in reducing BC emission and controlling air pollution.

Testing and reference model analysis of FTTH system

NASA Astrophysics Data System (ADS)

Feng, Xiancheng; Cui, Wanlong; Chen, Ying

2009-08-01

With rapid development of Internet and broadband access network, the technologies of xDSL, FTTx+LAN , WLAN have more applications, new network service emerges in endless stream, especially the increase of network game, meeting TV, video on demand, etc. FTTH supports all present and future service with enormous bandwidth, including traditional telecommunication service, traditional data service and traditional TV service, and the future digital TV and VOD. With huge bandwidth of FTTH, it wins the final solution of broadband network, becomes the final goal of development of optical access network.. Fiber to the Home (FTTH) will be the goal of telecommunications cable broadband access. In accordance with the development trend of telecommunication services, to enhance the capacity of integrated access network, to achieve triple-play (voice, data, image), based on the existing optical Fiber to the curb (FTTC), Fiber To The Zone (FTTZ), Fiber to the Building (FTTB) user optical cable network, the optical fiber can extend to the FTTH system of end-user by using EPON technology. The article first introduced the basic components of FTTH system; and then explain the reference model and reference point for testing of the FTTH system; Finally, by testing connection diagram, the testing process, expected results, primarily analyze SNI Interface Testing, PON interface testing, Ethernet performance testing, UNI interface testing, Ethernet functional testing, PON functional testing, equipment functional testing, telephone functional testing, operational support capability testing and so on testing of FTTH system. ...

MSFC institutional area network and ATM technology

NASA Technical Reports Server (NTRS)

Amin, Ashok T.

1994-01-01

The New Institutional Area Network (NEWIAN) at Marshall supports over 5000 end users with access to 26 file servers providing work presentation services. It is comprised of some 150 Ethernet LAN's interconnected by bridges/routers which are in turn connected to servers over two dual FDDI rings. The network supports various higher level protocols such as IP, IPX, AppleTalk (AT), and DECNet. At present IPX and AT protocols packets are routed, and IP protocol packets are bridged; however, work is in progress to route all IP packets. The impact of routing IP packets on network operation is examined. Broadband Integrated Services Data Network (BISDN), presently at various stages of development, is intended to provide voice, video, and data transfer services over a single network. BISDN will use asynchronous transfer mode (ATM) as a data transfer technique which provides for transmission, multiplexing, switching, and relaying of small size data units called cells. Limited ATM Wide Area Network (WAN) services are offered by Wiltel, AT&T, Sprint, and others. NASA is testing a pilot ATM WAN with a view to provide Program Support Communication Network services using ATM. ATM supports wide range of data rates and quality of service requirements. It is expected that ATM switches will penetrate campus networks as well. However, presently products in these areas are at various stages of development and standards are not yet complete. We examine development of ATM to help assess its role in the evolution of NEWIAN.

The UNIX Operating System in Libraries: Advantages of LAN's and Bulletin Board Systems in Your Library.

ERIC Educational Resources Information Center

Rose, Phillip E.

1988-01-01

Describes the experiences of the AT&T Technical Library in installing a local area network (LAN) and bulletin board using the UNIX operating system. Reasons why a LAN was needed, how the system works, and hardware and software used are discussed. (1 reference) (MES)

Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice.

PubMed

Hogan, Matthew K; Kovalycsik, Taylor; Sun, Qinghua; Rajagopalan, Sanjay; Nelson, Randy J

2015-11-01

Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has been implicated in several CNS disorders. The combinatorial role of these pollutants on health outcomes has not been assessed. Male C3H/HeNHsd mice, with intact melatonin production, were used to model humans exposed to circadian disruption by dLAN and contaminated environmental air. We hypothesized exposure to 2.5 μm of particulate matter (PM2.5) and dLAN (5lx) combines to upregulate neuroinflammatory cytokine expression and alter hippocampal morphology compared to mice exposed to filtered air (FA) and housed under dark nights (LD). We also hypothesized that exposure to PM2.5 and dLAN provokes anxiety-like and depressive-like responses. For four weeks, four groups of mice were simultaneously exposed to ambient concentrated PM2.5 or FA and/or dLAN or LD. Following exposure, mice underwent several behavioral assays and hippocampi were collected for qPCR and morphological analyses. Our results are generally comparable to previous PM2.5 and dLAN reports conducted on mice and implicate PM2.5 and dLAN as potential factors contributing to depression and anxiety. Short-term exposure to PM2.5 and dLAN upregulated neuroinflammatory cytokines and altered CA1 hippocampal structural changes, as well as provoked depressive-like responses (anhedonia). However, combined, PM2.5 and dLAN exposure did not have additive effects, as hypothesized, suggesting a ceiling effect of neuroinflammation may exist in response to multiple pollutants. Copyright © 2015 Elsevier B.V. All rights reserved.

Providing Access to CD-ROM Databases in a Campus Setting. Part II: Networking CD-ROMs via a LAN.

ERIC Educational Resources Information Center

Koren, Judy

1992-01-01

The second part of a report on CD-ROM networking in libraries describes LAN (local area network) technology; networking software and towers; gateway software for connecting to campuswide networks; Macintosh LANs; and network licenses. Several product and software reviews are included, and a sidebar lists vendor addresses. (NRP)

Coordinating Council. Eighth Meeting: Using the Internet

NASA Technical Reports Server (NTRS)

1992-01-01

This NASA Scientific and Technical Information Program Coordinating Council meeting theme was entitled 'Using Internet'. Individual topics included STI LAN migration, NSF and NREN (National Science Foundation and the National Research and Education Network), and the New NASA Headquarters LAN. Discussions are recorded for each topic and visuals are provided for STI LAN migration and NSI - NASA Science Internet.

Expansion of the phosphatidylethanolamine binding protein family in legumes: a case study of Lupinus angustifolius L. FLOWERING LOCUS T homologs, LanFTc1 and LanFTc2.

PubMed

Książkiewicz, Michał; Rychel, Sandra; Nelson, Matthew N; Wyrwa, Katarzyna; Naganowska, Barbara; Wolko, Bogdan

2016-10-21

The Arabidopsis FLOWERING LOCUS T (FT) gene, a member of the phosphatidylethanolamine binding protein (PEBP) family, is a major controller of flowering in response to photoperiod, vernalization and light quality. In legumes, FT evolved into three, functionally diversified clades, FTa, FTb and FTc. A milestone achievement in narrow-leafed lupin (Lupinus angustifolius L.) domestication was the loss of vernalization responsiveness at the Ku locus. Recently, one of two existing L. angustifolius homologs of FTc, LanFTc1, was revealed to be the gene underlying Ku. It is the first recorded involvement of an FTc homologue in vernalization. The evolutionary basis of this phenomenon in lupin has not yet been deciphered. Bacterial artificial chromosome (BAC) clones carrying LanFTc1 and LanFTc2 genes were localized in different mitotic chromosomes and constituted sequence-specific landmarks for linkage groups NLL-10 and NLL-17. BAC-derived superscaffolds containing LanFTc genes revealed clear microsyntenic patterns to genome sequences of nine legume species. Superscaffold-1 carrying LanFTc1 aligned to regions encoding one or more FT-like genes whereas superscaffold-2 mapped to a region lacking such a homolog. Comparative mapping of the L. angustifolius genome assembly anchored to linkage map localized superscaffold-1 in the middle of a 15 cM conserved, collinear region. In contrast, superscaffold-2 was found at the edge of a 20 cM syntenic block containing highly disrupted collinearity at the LanFTc2 locus. 118 PEBP-family full-length homologs were identified in 10 legume genomes. Bayesian phylogenetic inference provided novel evidence supporting the hypothesis that whole-genome and tandem duplications contributed to expansion of PEBP-family genes in legumes. Duplicated genes were subjected to strong purifying selection. Promoter analysis of FT genes revealed no statistically significant sequence similarity between duplicated copies; only RE-alpha and CCAAT-box motifs were found at conserved positions and orientations. Numerous lineage-specific duplications occurred during the evolution of legume PEBP-family genes. Whole-genome duplications resulted in the origin of subclades FTa, FTb and FTc and in the multiplication of FTa and FTb copy number. LanFTc1 is located in the region conserved among all main lineages of Papilionoideae. LanFTc1 is a direct descendant of ancestral FTc, whereas LanFTc2 appeared by subsequent duplication.

Study of atmospheric CH4 mole fractions at three WMO/GAW stations in China

NASA Astrophysics Data System (ADS)

Fang, Shuang-Xi; Zhou, Ling-Xi; Masarie, Kenneth A.; Xu, Lin; Rella, Chris W.

2013-05-01

CH4 mole fractions were continuously measured from 2009 to 2011 at three WMO/GAW stations in China (Lin'an, LAN; Longfengshan, LFS; and Waliguan, WLG) using three Cavity Ring Down Spectroscopy instruments. LAN and LFS are GAW regional measurement stations. LAN is located in China's most economically developed region, and LFS is in a rice production area (planting area > 40,000 km2). WLG is a global measurement station in remote northwest China. At LAN, high methane mole fractions are observed in all seasons. Surface winds from the northeast enhance CH4 values, with a maximum increase of 32 ± 15 ppb in summer. The peak to peak amplitude of the seasonal cycle is 77 ± 35 ppb. At LFS, the diurnal cycle amplitude is approximately constant throughout the year except summer, when a value of 196 ± 65 ppb is observed. CH4 values at LFS reach their peak in July, which is different from seasonal variations typically observed in the northern hemisphere. CH4 mole fractions at WLG show both the smallest values and the lowest variability. Maximum values occur during summer, which is different from other northern hemisphere WMO/GAW global stations. The seasonal cycle amplitude is 17 ± 11 ppb. The linear growth rates at LAN, LFS, and WLG are 8.0 ± 1.2, 7.9 ± 0.9, and 9.4 ± 0.2 ppb yr-1, respectively, which are all larger than the global mean over the same 3 year period. Results from this study attempt to improve our basic understanding of observed atmospheric CH4 in China.

Preparing culture change agents for academic medicine in a multi-institutional consortium: the C - change learning action network.

PubMed

Pololi, Linda H; Krupat, Edward; Schnell, Eugene R; Kern, David E

2013-01-01

Research suggests an ongoing need for change in the culture of academic medicine. This article describes the structure, activities and evaluation of a culture change project: the C - Change Learning Action Network (LAN) and its impact on participants. The LAN was developed to create the experience of a culture that would prepare participants to facilitate a culture in academic medicine that would be more collaborative, inclusive, relational, and that supports the humanity and vitality of faculty. Purposefully diverse faculty, leaders, and deans from 5 US medical schools convened in 2 1/2-day meetings biannually over 4 years. LAN meetings employed experiential, cognitive, and affective learning modes; innovative dialogue strategies; and reflective practice aimed at facilitating deep dialogue, relationship formation, collaboration, authenticity, and transformative learning to help members experience the desired culture. Robust aggregated qualitative and quantitative data collected from the 5 schools were used to inform and stimulate culture-change plans. Quantitative and qualitative evaluation methods were used. Participants indicated that a safe, supportive, inclusive, collaborative culture was established in LAN and highly valued. LAN members reported a deepened understanding of organizational change, new and valued interpersonal connections, increased motivation and resilience, new skills and approaches, increased self-awareness and personal growth, emotional connection to the issues of diversity and inclusion, and application of new learnings in their work. A carefully designed multi-institutional learning community can transform the way participants experience and view institutional culture. It can motivate and prepare them to be change agents in their own institutions. Copyright © 2013 The Alliance for Continuing Education in the Health Professions, the Society for Academic Continuing Medical Education, and the Council on CME, Association for Hospital Medical Education.

Role of Light in Breast Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stevens, Richard G.; Anderson, Larry E.; Michael F. Holick

1999-06-14

There is a prima facie reason for studying possible biological effects of light-at-night (LAN) in the laboratory and human health effects in the population at large: LAN from the use of electricity represent exposures in the human environment not previously encountered in human evolution. These LAN exposures are pervasive in industrialized societies, and any adverse health effects from them could result in considerable consequences for the population. In particular, exposures of pregnant women to LAN that might result in increased estrogen exposure in utero to their child may lead to increased tissue mass and increased lifetime risk of breast cancermore » of the child.« less

Antitumor effect of combination of the inhibitors of two new oncotargets: proton pumps and reverse transcriptase.

PubMed

Lugini, Luana; Sciamanna, Ilaria; Federici, Cristina; Iessi, Elisabetta; Spugnini, Enrico Pierluigi; Fais, Stefano

2017-01-17

Tumor therapy needs new approaches in order to improve efficacy and reduce toxicity of the current treatments. The acidic microenvironment and the expression of high levels of endogenous non-telomerase reverse transcriptase (RT) are common features of malignant tumor cells. The anti-acidic proton pump inhibitor Lansoprazole (LAN) and the non-nucleoside RT inhibitor Efavirenz (EFV) have shown independent antitumor efficacy. LAN has shown to counteract drug tumor resistance. We tested the hypothesis that combination of LAN and EFV may improve the overall antitumor effects. We thus pretreated human metastatic melanoma cells with LAN and then with EFV, both in 2D and 3D spheroid models. We evaluated the treatment effect by proliferation and cell death/apoptosis assays in classical and in pulse administration experiments. The action of EFV was negatively affected by the tumor microenvironmental acidity, and LAN pretreatment overcame the problem. LAN potentiated the cytotoxicity of EFV to melanoma cells and, when administered during the drug interruption period, prevented the replacement of tumor cell growth.This study supports the implementation of the current therapies with combination of Proton Pumps and Reverse Transcriptase inhibitors.

Antitumor effect of combination of the inhibitors of two new oncotargets: proton pumps and reverse transcriptase

PubMed Central

Lugini, Luana; Sciamanna, Ilaria; Federici, Cristina; Iessi, Elisabetta; Spugnini, Enrico Pierluigi; Fais, Stefano

2017-01-01

Tumor therapy needs new approaches in order to improve efficacy and reduce toxicity of the current treatments. The acidic microenvironment and the expression of high levels of endogenous non-telomerase reverse transcriptase (RT) are common features of malignant tumor cells. The anti-acidic proton pump inhibitor Lansoprazole (LAN) and the non-nucleoside RT inhibitor Efavirenz (EFV) have shown independent antitumor efficacy. LAN has shown to counteract drug tumor resistance. We tested the hypothesis that combination of LAN and EFV may improve the overall antitumor effects. We thus pretreated human metastatic melanoma cells with LAN and then with EFV, both in 2D and 3D spheroid models. We evaluated the treatment effect by proliferation and cell death/apoptosis assays in classical and in pulse administration experiments. The action of EFV was negatively affected by the tumor microenvironmental acidity, and LAN pretreatment overcame the problem. LAN potentiated the cytotoxicity of EFV to melanoma cells and, when administered during the drug interruption period, prevented the replacement of tumor cell growth. This study supports the implementation of the current therapies with combination of Proton Pumps and Reverse Transcriptase inhibitors. PMID:27926505

Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters.

PubMed

Bedrosian, Tracy A; Fonken, Laura K; Walton, James C; Nelson, Randy J

2011-06-23

Species have been adapted to specific niches optimizing survival and reproduction; however, urbanization by humans has dramatically altered natural habitats. Artificial light at night (LAN), termed 'light pollution', is an often overlooked, yet increasing disruptor of habitats, which perturbs physiological processes that rely on precise light information. For example, LAN alters the timing of reproduction and activity in some species, which decreases the odds of successful breeding and increases the threat of predation for these individuals, leading to reduced fitness. LAN also suppresses immune function, an important proxy for survival. To investigate the impact of LAN in a species naive to light pollution in its native habitat, immune function was examined in Siberian hamsters derived from wild-caught stock. After four weeks exposure to dim LAN, immune responses to three different challenges were assessed: (i) delayed-type hypersensitivity (DTH), (ii) lipopolysaccharide-induced fever, and (iii) bactericide activity of blood. LAN suppressed DTH response and reduced bactericide activity of blood after lipopolysaccharide treatment, in addition to altering daily patterns of locomotor activity, suggesting that human encroachment on habitats via night-time lighting may inadvertently compromise immune function and ultimately fitness.

Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor.

PubMed

Kumagai, Takeshi; Aratsu, Yusuke; Sugawara, Ryosuke; Sasaki, Takamitsu; Miyairi, Shinichi; Nagata, Kiyoshi

2016-04-01

Ban-Lan-Gen is the common name for the dried roots of indigo plants, including Polygonum tinctorium, Isatis indigotica, Isatis tinctoria, and Strobilanthes cusia. Ban-Lan-Gen is frequently used as an anti-inflammatory and an anti-viral for the treatment of hepatitis, influenza, and various types of inflammation. One of the cytochrome P450 (CYP) enzymes, CYP3A4, is responsible for the metabolism of a wide variety of xenobiotics, including an estimated 60% of all clinically used drugs. In this study, we investigated the effect of Ban-Lan-Gen on the transcriptional activation of the CYP3A4 gene. Ban-Lan-Gen extract increased CYP3A4 gene reporter activity in a dose-dependent manner. Indirubin, one of the biologically active ingredients in the Ban-Lan-Gen, also dose-dependently increased CYP3A4 gene reporter activity. Expression of short hairpin RNA for the human pregnane X receptor (hPXR-shRNA) inhibited CYP3A4 gene reporter activity, and overexpression of human PXR increased indirubin- and rifampicin-induced CYP3A4 gene reporter activity. Furthermore, indirubin induced CYP3A4 mRNA expression in HepG2 cells. Taken together, these results indicate that indirubin, a component of Ban-Lan-Gen, activated CYP3A4 gene transcription through the activation of the human PXR. Copyright © 2016. Published by Elsevier Ltd.

Outline of Toshiba Business Information Center

NASA Astrophysics Data System (ADS)

Nagata, Yoshihiro

Toshiba Business Information Center gathers and stores inhouse and external business information used in common within the Toshiba Corp., and provides companywide circulation, reference and other services. The Center established centralized information management system by employing decentralized computers, electronic file apparatus (30cm laser disc) and other office automation equipments. Online retrieval through LAN is available to search the stored documents and increasing copying requests are processed by electronic file. This paper describes the purpose of establishment of the Center, the facilities, management scheme, systematization of the files and the present situation and plan of each information service.

Dim light at night disturbs the daily sleep-wake cycle in the rat.

PubMed

Stenvers, Dirk Jan; van Dorp, Rick; Foppen, Ewout; Mendoza, Jorge; Opperhuizen, Anne-Loes; Fliers, Eric; Bisschop, Peter H; Meijer, Johanna H; Kalsbeek, Andries; Deboer, Tom

2016-10-20

Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of ~25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia.

Dim light at night disturbs the daily sleep-wake cycle in the rat

PubMed Central

Jan Stenvers, Dirk; van Dorp, Rick; Foppen, Ewout; Mendoza, Jorge; Opperhuizen, Anne-Loes; Fliers, Eric; Bisschop, Peter H.; Meijer, Johanna H.; Kalsbeek, Andries; Deboer, Tom

2016-01-01

Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150–200lux):12 h dark (LD) schedule or a 12 h light (150–200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16–19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of ~25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia. PMID:27762290

Business is Beaming

NASA Technical Reports Server (NTRS)

2001-01-01

Terabeam has developed a Fiberless Optical(TM) Network that transmits broadband data from office buildings to the nation's wide-area networks (WANs), without digging up the streets. A key component of Terabeam's Fiberless Network is Large Aperture Holographic Optic technology, developed by Ralcon Development Lab, of Paradise, Utah. Ralcon developed the Holographic Optical Element (HOE) technology with assistance from a NASA Goddard Space Flight Center Small Business Innovation Research (SBIR) contract. Terabeam further developed the HOE technology and incorporated it into its Fiberless Optical Network-sending an immeasurable amount of information soaring overhead. Terabeam developed its Fiberless Optical Network using a proprietary HOE to transmit data. The unit is mounted near an office window and has the ability to beam safe, low-power, invisible data through the air at gigabits-per-second speeds to anywhere in the service area. Gigabits-per-second speeds are thousands of times faster than the speeds of current broadband transmissions. This allows businesses to connect to local-area networks (LANs) as well as WANs, in a quick and affordable manner.

Highly turbulent solutions of the Lagrangian-averaged Navier-Stokes alpha model and their large-eddy-simulation potential.

PubMed

Pietarila Graham, Jonathan; Holm, Darryl D; Mininni, Pablo D; Pouquet, Annick

2007-11-01

We compute solutions of the Lagrangian-averaged Navier-Stokes alpha - (LANS alpha ) model for significantly higher Reynolds numbers (up to Re approximately 8300 ) than have previously been accomplished. This allows sufficient separation of scales to observe a Navier-Stokes inertial range followed by a second inertial range specific to the LANS alpha model. Both fully helical and nonhelical flows are examined, up to Reynolds numbers of approximately 1300. Analysis of the third-order structure function scaling supports the predicted l3 scaling; it corresponds to a k-1 scaling of the energy spectrum for scales smaller than alpha. The energy spectrum itself shows a different scaling, which goes as k1. This latter spectrum is consistent with the absence of stretching in the subfilter scales due to the Taylor frozen-in hypothesis employed as a closure in the derivation of the LANS alpha model. These two scalings are conjectured to coexist in different spatial portions of the flow. The l3 [E(k) approximately k-1] scaling is subdominant to k1 in the energy spectrum, but the l3 scaling is responsible for the direct energy cascade, as no cascade can result from motions with no internal degrees of freedom. We demonstrate verification of the prediction for the size of the LANS alpha attractor resulting from this scaling. From this, we give a methodology either for arriving at grid-independent solutions for the LANS alpha model, or for obtaining a formulation of the large eddy simulation optimal in the context of the alpha models. The fully converged grid-independent LANS alpha model may not be the best approximation to a direct numerical simulation of the Navier-Stokes equations, since the minimum error is a balance between truncation errors and the approximation error due to using the LANS alpha instead of the primitive equations. Furthermore, the small-scale behavior of the LANS alpha model contributes to a reduction of flux at constant energy, leading to a shallower energy spectrum for large alpha. These small-scale features, however, do not preclude the LANS alpha model from reproducing correctly the intermittency properties of the high-Reynolds-number flow.

The Effects of Blast Trauma (Impulse Noise) on Hearing: A Parametric Study

DTIC Science & Technology

1988-07-22

8217 q 2~~L m AALLA LAN LALALA v O 0- N( N N r4OD r: el LAr:r: v) 0n n LALALAL LAn LA vLnLA LAL LO 55 0 w * . . * 0 * * * * 0 w4 I n 4)L nL nr n nL nL nr...0ý LnLn LLLA r-in toN fLn Ln oA LA(n C.* * . . . * 10 C0 -. ~~0, NN m- AULA v *- r4~~~ ~- -1 H~i-r -4C (’eN r4* ntni L Len LAo mS- rLAn f m 04 0D LAAALL...C r-: 4 ýr- r- r-o8*i c oG o - G D% vooi %Vr- r- -4 ’-4 ( DE 0n u) tn A tn r- gn Ln .An inLn .n c4 0) 91 * . . ** Nn * LAn’Ln~ Ln to~ uiL . n nL n 040

Low Incidence of Gastrointestinal Adverse Events Over Time with a Fixed-Ratio Combination of Insulin Glargine and Lixisenatide vs Lixisenatide Alone.

PubMed

Trujillo, Jennifer M; Roberts, Michelle; Dex, Terry; Chao, Jason; John White, Pa-C; LaSalle, James

2018-06-19

This post hoc analysis of gastrointestinal (GI) adverse events (AEs) from the phase 3 LixiLan-L (NCT02058160) and LixiLan-O (NCT02058147) trials aimed to determine the frequency and timing of nausea, vomiting, and diarrhea for iGlarLixi, a titratable, fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide, vs iGlar alone or iGlar and lixisenatide alone, in patients with type 2 diabetes uncontrolled with oral antidiabetes drugs (OADs) or basal insulin ± OADs. In iGlarLixi-treated patients, the rate of GI AEs during initial weeks of treatment was lower vs patients treated with lixisenatide alone (9.6% and 11.7% of iGlarLixi-treated patients in LixiLan-L and LixiLan-O, respectively, vs 27.5% of lixisenatide-treated patients in LixiLan-O). Beyond Day 60, these rates were generally low and similar to those of lixisenatide. These lower rates are likely due to the gradual titration of lixisenatide in iGlarLixi. Median durations of intermittent GI AEs in the iGlarLixi arms were 6.0, 2.0 and 2.5 days (LixiLan-L), and 5.0, 1.0 and 3.5 days (LixiLan-O), respectively. iGlarLixi-associated GI AEs were transient, mostly mild or moderate in severity, and occurred mainly during initial titration. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Dim light at night disrupts the short-day response in Siberian hamsters.

PubMed

Ikeno, Tomoko; Weil, Zachary M; Nelson, Randy J

2014-02-01

Photoperiodic regulation of physiology, morphology, and behavior is crucial for many animals to survive seasonally variable conditions unfavorable for reproduction and survival. The photoperiodic response in mammals is mediated by nocturnal secretion of melatonin under the control of a circadian clock. However, artificial light at night caused by recent urbanization may disrupt the circadian clock, as well as the photoperiodic response by blunting melatonin secretion. Here we examined the effect of dim light at night (dLAN) (5lux of light during the dark phase) on locomotor activity rhythms and short-day regulation of reproduction, body mass, pelage properties, and immune responses of male Siberian hamsters. Short-day animals reduced gonadal and body mass, decreased spermatid nuclei and sperm numbers, molted to a whiter pelage, and increased pelage density compared to long-day animals. However, animals that experienced short days with dLAN did not show these short-day responses. Moreover, short-day specific immune responses were altered in dLAN conditions. The nocturnal activity pattern was blunted in dLAN hamsters, consistent with the observation that dLAN changed expression of the circadian clock gene, Period1. In addition, we demonstrated that expression levels of genes implicated in the photoperiodic response, Mel-1a melatonin receptor, Eyes absent 3, thyroid stimulating hormone receptor, gonadotropin-releasing hormone, and gonadotropin-inhibitory hormone, were higher in dLAN animals than those in short-day animals. These results suggest that dLAN disturbs the circadian clock function and affects the molecular mechanisms of the photoperiodic response. Copyright © 2013 Elsevier Inc. All rights reserved.

Malware Pandemics

DTIC Science & Technology

2010-09-01

in T-Mobile’s ,𔃽G IP range began expe- riencing extortion popup windows. The popup window notifies the victim that the phone has been hacked , and...range, 192.168.0.0/16. Such scanning may be of particular interest when the victim’s iPhone opportunistically connects to a WiFi LAN for Internet...connected to local WiFi networks should understand that the convenience of their Internet-tethered web, media, and email service, comes with a

Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation.

PubMed

Schwimmer, Hagit; Metzer, Avishag; Pilosof, Yonit; Szyf, Moshe; Machnes, Ziv M; Fares, Fuad; Harel, Orna; Haim, Abraham

2014-02-01

Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.

A network security monitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heberlein, L.T.; Dias, G.V.; Levitt, K.N.

1989-11-01

The study of security in computer networks is a rapidly growing area of interest because of the proliferation of networks and the paucity of security measures in most current networks. Since most networks consist of a collection of inter-connected local area networks (LANs), this paper concentrates on the security-related issues in a single broadcast LAN such as Ethernet. Specifically, we formalize various possible network attacks and outline methods of detecting them. Our basic strategy is to develop profiles of usage of network resources and then compare current usage patterns with the historical profile to determine possible security violations. Thus, ourmore » work is similar to the host-based intrusion-detection systems such as SRI's IDES. Different from such systems, however, is our use of a hierarchical model to refine the focus of the intrusion-detection mechanism. We also report on the development of our experimental LAN monitor currently under implementation. Several network attacks have been simulated and results on how the monitor has been able to detect these attacks are also analyzed. Initial results demonstrate that many network attacks are detectable with our monitor, although it can surely be defeated. Current work is focusing on the integration of network monitoring with host-based techniques. 20 refs., 2 figs.« less

Development of Protection and Control Unit for Distribution Substation

NASA Astrophysics Data System (ADS)

Iguchi, Fumiaki; Hayashi, Hideyuki; Takeuchi, Motohiro; Kido, Mitsuyasu; Kobayashi, Takashi; Yanaoka, Atsushi

The Recently, electronics and IT technologies have been rapidly innovated and have been introduced to power system protection & control system to achieve high reliability, maintainability and more functionality. Concerning the distribution substation application, digital relays have been applied for more than 10 years. Because of a number of electronic devices used for it, product cost becomes higher. Also, products installed during the past high-growth period will be at the end of lifetime and will be replaced. Therefore, replacing market is expected to grow and the reduction of cost is demanded. Considering above mentioned background, second generation digital protection and control unit as a successor is designed to have following concepts. Functional integration based on advanced digital technologies, Ethernet LAN based indoor communication network, cost reduction and downsizing. Pondering above concepts, integration of protection and control function is adopted in contrary to the functional segregation applied to the previous system in order to achieve one-unit concept. Also the adoption of Ethernet LAN for inter-unit communication is objective. This report shows the development of second-generation digital relay for distribution substation, which is equipped with control function and Ethernet LAN by reducing the size of auxiliary transformer unit and the same size as previous product is realized.

Micros for the 1990's: An Update.

ERIC Educational Resources Information Center

Grosch, Audrey N.

1991-01-01

Discusses new hardware and software developments for microcomputers and considers strategies for future library microcomputing. Topics discussed include developments with Macintosh computers; the importance of local area networks (LANs); upgrading options for hardware; operating system upgrades; dynamic data exchange (DDE); microcomputer…

Comparison of Ga-68 DOTA-TATE and Ga-68 DOTA-LAN PET/CT imaging in the same patient group with neuroendocrine tumours: preliminary results.

PubMed

Demirci, Emre; Ocak, Meltem; Kabasakal, Levent; Araman, Ahmet; Ozsoy, Yildiz; Kanmaz, Bedii

2013-08-01

Recent studies have suggested that PET imaging with Ga-68-labelled DOTA-somatostatin analogues such as octreotide and octreotate is useful in diagnosing neuroendocrine tumours (NETs) and has superior value over both computed tomography and planar and SPECT somatostatin receptor scintigraphy. The aim of the present study was to evaluate the role of Ga-68 DOTA-lanreotide (Ga-68-DOTA-LAN) in patients with somatostatin receptor (sst)-expressing tumours and to compare the results of Ga-68 DOTA-D-Phe1-Tyr3-octreotate (Ga-68-DOTA-TATE) in the same patient population. Twelve patients with NETs who were referred to our department for somatostatin receptor scintigraphy were included in the study. There were four patients with well-differentiated neuroendocrine tumour (WDNET) grade 1, two patients with WDNET grade 2, and three patients with poorly differentiated neuroendocrine carcinoma (PDNEC) grade 3. There was also one patient with medullary thyroid cancer, one patient with meningioma and one patient with MEN-1. All patients underwent two consecutive PET imaging studies with Ga-68-DOTA-TATE and Ga-68 DOTA-LAN. All images were evaluated visually, and maximum standardized uptake value was calculated for quantitative evaluation. On visual examination of maximum intensity projection images, GA-68 DOTA-LAN was seen to have high background activity and high bone marrow uptake. Both tracers defined 67 lesions. Ga-68 DOTA-TATE images revealed 63 (94%) clearly defined lesions, missing four lesions. In contrast, Ga-68 DOTA-LAN images defined only 23 (44%) lesions, missing 44 (56%) lesions. Thirty-two bone lesions were detected on Ga-68-DOTA-TATE images. Among them, only 11 (34%) were positive on Ga-68 DOTA-LAN images, whereas 21 (66%) were negative. When we evaluated liver, mediastinum and gastrointestinal tract lesions, Ga-68 DOTA-LAN was seen to be positive for 12 (34%) lesions and negative for 23 (66%) lesions. Although the results are preliminary, the image quality obtained by Ga-68-DOTA-TATE seems to be superior to that obtained by Ga-68 DOTA-LAN. With its significantly higher lesion uptake and higher ability to detect lesions, Ga-68-DOTA-TATE seems to be a better radioligand compared with Ga-68-DOTA-LAN for the diagnosis of NETs.

Wireless LAN security management with location detection capability in hospitals.

PubMed

Tanaka, K; Atarashi, H; Yamaguchi, I; Watanabe, H; Yamamoto, R; Ohe, K

2012-01-01

In medical institutions, unauthorized access points and terminals obstruct the stable operation of a large-scale wireless local area network (LAN) system. By establishing a real-time monitoring method to detect such unauthorized wireless devices, we can improve the efficiency of security management. We detected unauthorized wireless devices by using a centralized wireless LAN system and a location detection system at 370 access points at the University of Tokyo Hospital. By storing the detected radio signal strength and location information in a database, we evaluated the risk level from the detection history. We also evaluated the location detection performance in our hospital ward using Wi-Fi tags. The presence of electric waves outside the hospital and those emitted from portable game machines with wireless communication capability was confirmed from the detection result. The location detection performance showed an error margin of approximately 4 m in detection accuracy and approximately 5% in false detection. Therefore, it was effective to consider the radio signal strength as both an index of likelihood at the detection location and an index for the level of risk. We determined the location of wireless devices with high accuracy by filtering the detection results on the basis of radio signal strength and detection history. Results of this study showed that it would be effective to use the developed location database containing radio signal strength and detection history for security management of wireless LAN systems and more general-purpose location detection applications.

A system for distributed intrusion detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snapp, S.R.; Brentano, J.; Dias, G.V.

1991-01-01

The study of providing security in computer networks is a rapidly growing area of interest because the network is the medium over which most attacks or intrusions on computer systems are launched. One approach to solving this problem is the intrusion-detection concept, whose basic premise is that not only abandoning the existing and huge infrastructure of possibly-insecure computer and network systems is impossible, but also replacing them by totally-secure systems may not be feasible or cost effective. Previous work on intrusion-detection systems were performed on stand-alone hosts and on a broadcast local area network (LAN) environment. The focus of ourmore » present research is to extend our network intrusion-detection concept from the LAN environment to arbitarily wider areas with the network topology being arbitrary as well. The generalized distributed environment is heterogeneous, i.e., the network nodes can be hosts or servers from different vendors, or some of them could be LAN managers, like our previous work, a network security monitor (NSM), as well. The proposed architecture for this distributed intrusion-detection system consists of the following components: a host manager in each host; a LAN manager for monitoring each LAN in the system; and a central manager which is placed at a single secure location and which receives reports from various host and LAN managers to process these reports, correlate them, and detect intrusions. 11 refs., 2 figs.« less

Name-Based Address Mapping for Virtual Private Networks

NASA Astrophysics Data System (ADS)

Surányi, Péter; Shinjo, Yasushi; Kato, Kazuhiko

IPv4 private addresses are commonly used in local area networks (LANs). With the increasing popularity of virtual private networks (VPNs), it has become common that a user connects to multiple LANs at the same time. However, private address ranges for LANs frequently overlap. In such cases, existing systems do not allow the user to access the resources on all LANs at the same time. In this paper, we propose name-based address mapping for VPNs, a novel method that allows connecting to hosts through multiple VPNs at the same time, even when the address ranges of the VPNs overlap. In name-based address mapping, rather than using the IP addresses used on the LANs (the real addresses), we assign a unique virtual address to each remote host based on its domain name. The local host uses the virtual addresses to communicate with remote hosts. We have implemented name-based address mapping for layer 3 OpenVPN connections on Linux and measured its performance. The communication overhead of our system is less than 1.5% for throughput and less than 0.2ms for each name resolution.

Dim Light at Night Increases Body Mass of Female Mice

PubMed Central

Aubrecht, Taryn G.; Jenkins, Richelle; Nelson, Randy J.

2016-01-01

During the past century the prevalence of light at night has increased in parallel with obesity rates. Dim light at night (dLAN) increases body mass in male mice. However, the effects of light at night on female body mass remain unspecified. Thus, female mice were exposed to a standard light/dark (LD; 16h light at ~150 lux/8h dark at ~0 lux) cycle or to light/dim light at night (dLAN; 16h light at ~150 lux/8h dim light at ~5 lux) cycles for six weeks. Females exposed to dLAN increased the rate of change in body mass compared to LD mice despite reduced total food intake during weeks five and six, suggesting that dLAN disrupted circadian rhythms resulting in deranged metabolism. PMID:25431079

Packet-aware transport for video distribution [Invited

NASA Astrophysics Data System (ADS)

Aguirre-Torres, Luis; Rosenfeld, Gady; Bruckman, Leon; O'Connor, Mannix

2006-05-01

We describe a solution based on resilient packet rings (RPR) for the distribution of broadcast video and video-on-demand (VoD) content over a packet-aware transport network. The proposed solution is based on our experience in the design and deployment of nationwide Triple Play networks and relies on technologies such as RPR, multiprotocol label switching (MPLS), and virtual private LAN service (VPLS) to provide the most efficient solution in terms of utilization, scalability, and availability.

Laser Atmospheric Transmitter Receiver-Network (LAnTeRN): A new approach for active measurement of atmospheric greenhouse gases

NASA Astrophysics Data System (ADS)

Dobler, J. T.; Braun, M.; Zaccheo, T.

2012-12-01

The Laser Atmospheric Transmitter Receiver-Network (LAnTeRN) is a new measurement concept that will enable local, regional and continental determination of key greenhouse gases, with unparalleled accuracy and precision. This new approach will offer the ability to make low bias, high precision, quasi-continuous, measurements to the accuracies required for separating anthropogenic and biogenic sources and sinks. In 2004 ITT Exelis developed an airborne demonstration unit, based on an intensity modulated continuous wave (IM-CW) lidar approach, for actively measuring atmospheric CO2 and O2. The multi-functional fiber laser lidar (MFLL) system relies on low peak power, high reliability, and efficient telecom laser components to implement this unique measurement approach. While evaluating methods for discriminating against thin clouds for the MFLL instrument, a new measurement concept was conceived. LAnTeRN has several fundamental characteristics in common with the MFLL instrument, but is a fundamentally different implementation and capability. The key difference is that LAnTeRN operates in transmission rather than in the traditional backscatter lidar configuration, which has several distinct advantages. Operating as a forward scatter, bistatic lidar system, LAnTeRN enables consideration of continuous monitoring from a geostationary orbit to multiple locations on the ground. Having the receivers on the ground significantly lowers cost and risk compared to an all space based mission, and allows the transmitter subsystem to be implemented, near term, as a hosted payload. Furthermore, the LAnTeRN measurement approach is also applicable for ground to ground measurements where high precision measurements over a long open path is required, such as facilities monitoring, or monitoring of passive volcanoes and fault lines. Using narrow linewidth laser sources allows flexibility to select the position on the absorption feature being probed. This feature allows for weighting the absorption toward lower altitudes for the space implementation or to handle large dynamic range measurements as would be required for volcano monitoring. This presentation will discuss results from a detailed instrument performance analyses, retrieval simulations, and from initial testing of a proof of concept demonstration unit being developed by Exelis. Initial analysis indicate that measurements from a transmitter in geostationary orbit to 25 ground receivers in the eastern U.S. can retrieve column integrated CO2 values to a precision of <0.2 ppm on monthly averages and <0.06 ppm on yearly averages, using conservative estimates of cloud cover and aerosol loading. The capability for continuous monitoring over a fixed geometry makes it possible to independently characterize the atmospheric column, using existing capabilities (e.g. aircore, aircraft and in-situ instrumentation), for quantification of bias. Furthermore, the ability to selectively locate the ground receivers can enable focused studies for specific applications.

The TurboLAN project. Phase 1: Protocol choices for high speed local area networks. Phase 2: TurboLAN Intelligent Network Adapter Card, (TINAC) architecture

NASA Technical Reports Server (NTRS)

Alkhatib, Hasan S.

1991-01-01

The hardware and the software architecture of the TurboLAN Intelligent Network Adapter Card (TINAC) are described. A high level as well as detailed treatment of the workings of various components of the TINAC are presented. The TINAC is divided into the following four major functional units: (1) the network access unit (NAU); (2) the buffer management unit; (3) the host interface unit; and (4) the node processor unit.

Definitie Rapport Taktisch LAN Demonstratie (Definition Report Tactical LAN Demonstration)

DTIC Science & Technology

1990-06-01

am deze sneiheid te halen . Hierover kan eon uitspraak warden gedaan, enerzijds na de ontwikkeling van het S-4 interface en anderzijds na berokeningen...90-A02 *2ma~D. Definitie rapport taktisch LAN Niels Ult deze urgave reai erorden verrnengvldigd er of openbaar genakt door MiddeI van druk. folokopre...microfrilm Of OP wetke arroere 00lze 000 00k. zonoe, O~u S vdorafgaanoe loestermeng van TNOHet ter inzage gen van het TNO-rapport Ing. R. J . C.14

Mini-Micro CDS/ISIS in the Thailand Development Research Institute Library.

ERIC Educational Resources Information Center

Wongkoltoot, Poonsin; Indee, Somsak

1992-01-01

Describes the Thailand Development Research Institute Library's development of an integrated bibliographic system using UNESCO's Micro-ISIS software. Linkages between databases were made using an in-house application (TIBIS) written in CDS/ISIS Pascal. The library system is available on a local area network (LAN). (three references) (EA)

Guidelines for hurricane evacuation signing and markings

DOT National Transportation Integrated Search

2007-12-01

Based on focus group input and surveys of motorists who have recent hurricane evacuation experience, researchers developed guidelines for various hurricane evacuation signs and markings, including route signs, contraflow signs, emergency shoulder lan...

Local Area Networks (The Printout).

ERIC Educational Resources Information Center

Aron, Helen; Balajthy, Ernest

1989-01-01

Describes the Local Area Network (LAN), a project in which students used LAN-based word processing and electronic mail software as the center of a writing process approach. Discusses the advantages and disadvantages of networking. (MM)

Nocturnal light exposure impairs affective responses in a wavelength-dependent manner.

PubMed

Bedrosian, Tracy A; Vaughn, Celynn A; Galan, Anabel; Daye, Ghassan; Weil, Zachary M; Nelson, Randy J

2013-08-07

Life on earth is entrained to a 24 h solar cycle that synchronizes circadian rhythms in physiology and behavior; light is the most potent entraining cue. In mammals, light is detected by (1) rods and cones, which mediate visual function, and (2) intrinsically photosensitive retinal ganglion cells (ipRGCs), which primarily project to the suprachiasmatic nucleus (SCN) in the hypothalamus to regulate circadian rhythms. Recent evidence, however, demonstrates that ipRGCs also project to limbic brain regions, suggesting that, through this pathway, light may have a role in cognition and mood. Therefore, it follows that unnatural exposure to light may have negative consequences for mood or behavior. Modern environmental lighting conditions have led to excessive exposure to light at night (LAN), and particularly to blue wavelength lights. We hypothesized that nocturnal light exposure (i.e., dim LAN) would induce depressive responses and alter neuronal structure in hamsters (Phodopus sungorus). If this effect is mediated by ipRGCs, which have reduced sensitivity to red wavelength light, then we predicted that red LAN would have limited effects on brain and behavior compared with shorter wavelengths. Additionally, red LAN would not induce c-Fos activation in the SCN. Our results demonstrate that exposure to LAN influences behavior and neuronal plasticity and that this effect is likely mediated by ipRGCs. Modern sources of LAN that contain blue wavelengths may be particularly disruptive to the circadian system, potentially contributing to altered mood regulation.

Obituary: Howard H. Lanning, 1946-2007

NASA Astrophysics Data System (ADS)

Wade, Richard A.; MacConnell, D. Jack

2009-01-01

Howard H. Lanning died 20 December 2007 in Tucson, Arizona. He was a Software Quality Assurance Engineer for the Data Products Program at the National Optical Astronomy Observatory [NOAO] in Tucson, having returned to his native West after twenty years at the Space Telescope Science Institute [STScI] in Baltimore, Maryland. Throughout his career in roles supporting other astronomers, Howard steadily and persistently worked at his own research programs, most notably the identification and study of UV-bright sources in the Sandage Two-Color Survey of the Galactic Plane. Minor planet 2000 QJ248 has been named (61913) Lanning in recognition of his contributions. The son of James Clyde Lanning and Ethel Malan Lanning, Howard was born 26 May 1946, in Brawley, a small community near Calipatria, California. His parents worked for the local school district where his late father was Superintendent of Maintenance and Grounds and his mother was a school principal. After graduating from high school in a class of 52, Howard earned his A.A. degree at Imperial Valley Junior College, majoring in Astronomy and minoring in Mathematics. He completed his A.B. degree in Applied Arts and Sciences at San Diego State University [SDSU] in 1969 with the same major and minor. In 1974, he completed his M.S. in Astronomy at SDSU with a thesis on the period variation of the white-dwarf eclipsing binary BD +16∘516. During his time at SDSU Lanning was a Research Assistant/Observer at the former Hale Observatories, working on the optical identification of X-ray sources under the direction of Allan Sandage. His second refereed paper, the first of several finding lists of UV-bright stars arising from this work, appeared in 1973. Fellow students and faculty remember that he was a self-starter, initiating many observing projects of his own at Mount Laguna Observatory and encouraging others to do the same. For more than a decade Lanning was an observer and night assistant at Mount Wilson Observatory, operating the 1.5m and 2.5m (Hooker) telescopes and supporting users. He was one of the principal observers in the HK project, which used the 1.5m to study the variations in chromospheric activity and rotational modulation of late-type stars. He used his observing time expertly to obtain photometry and spectroscopy of close binary stars for his own research projects. Former Caltech graduate students who were fortunate to have Lanning as a night assistant marveled at his knowledge of the telescopes and instrumentation, in particular his ability to read setting circles and acquire targets by engaging the gravity-driven clock drive of the Hooker telescope at exactly the right moment. In 1985 Lanning, with his wife, Sheryl Falgout, and stepson, Mario Lanning, relocated to Baltimore, to a position with Computer Sciences Corporation at STScI. He was an Operations Astronomer and then Software Testing Engineer, providing instrument and contact support for the Goddard High Resolution Spectrograph and the Space Telescope Imaging Spectrograph. In 2005, the family moved to Tucson and NOAO. His work on the UV-bright star survey continued at both locations, with various collaborators. Lanning was active in the broader astronomical community, writing newspaper articles on astronomy for the lay person; giving talks to civic groups, school children, and amateur astronomers; and, from 2006, coordinating the Donation Archive Program of the AAS. Lanning published 26 scientific papers in major journals, along with numerous other contributions, circulars, and technical reports. His finding lists and other studies of UV-bright stars, emphasizing crowded star fields where modern surveys have not probed, remain of value today. Several stars from these lists have turned out to be cataclysmic variables. Most recently, a study of the reduced proper motions of these objects has demonstrated that the Lanning stars are a rich source of heretofore unidentified white dwarfs. Lanning is survived by his wife of 25 years, a stepson, and his mother. The authors acknowledge valuable assistance from Sheryl Falgout, Burt Nelson, and Paul Etzel.

Free space optics: a viable last-mile alternative

NASA Astrophysics Data System (ADS)

Willebrand, Heinz A.; Clark, Gerald R.

2001-10-01

This paper explores Free Space Optics (FSO) as an access technology in the last mile of metropolitan area networks (MANs). These networks are based in part on fiber-optic telecommunications infrastructure, including network architectures of Synchronous Optical Network (commonly referred to as SONET), the North American standard for synchronous data transmission; and Synchronous Digital Hierarchy (commonly referred to as SDH), the international standard and equivalent of SONET. Several converging forces have moved FSO beyond a niche technology for use only in local area networks (LANs) as a bridge connecting two facilities. FSO now allows service providers to cost effectively provide optical bandwidth for access networks and accelerate the extension of metro optical networks bridging what has been termed by industry experts as the optical dead zone. The optical dead zone refers to both the slowdown in capital investment in the short-term future and the actual connectivity gap that exists today between core metro optical networks and the access optical networks. Service providers have built extensive core and minimal metro networks but have not yet provided optical bandwidth to the access market largely due to the non-compelling economics to bridge the dead zone with fiber. Historically, such infrastructure build-out slowdowns have been blamed on a combination of economics, time-to-market constraints and limited technology options. However, new technology developments and market acceptance of FSO give service providers a new cost-effective alternative to provide high-bandwidth services with optical bandwidth in the access networks. Merrill Lynch predicts FSO will grow into a $2 billion market by 2005. The drivers for this market are a mere 5%- 6% penetration of fiber to business buildings; cost effective solution versus RF or fiber; and significant capacity which can only be matched by a physical fiber link, Merrill Lynch reports. This paper will describe FSO technology, its capabilities and its limitations. The paper will investigate how FSO technology has evolved to its current stage for deployment in MANs, LANs, wireless backhaul and metropolitan network extensions - applications that fall within the category of last mile. The paper will address the market, drivers and the adoption of FSO, plus provide a projection of future FSO technology, based on today's product roadmaps. The paper concludes with a summary of findings and recommendations.

Using an Instructional LAN to Teach a Statistics Course.

ERIC Educational Resources Information Center

Barnes, J. Wesley; And Others

1988-01-01

Discusses a computer assisted learning system for engineering statistics based on personalized system of instruction methods. Describes the system's network, development, course structure, programing, and security. Lists the benefits of the system. (MVL)

Changing the culture of academic medicine: the C-Change learning action network and its impact at participating medical schools.

PubMed

Krupat, Edward; Pololi, Linda; Schnell, Eugene R; Kern, David E

2013-09-01

The culture of academic medicine has been described as hierarchical, competitive, and not highly supportive of female or minority faculty. In response to this, the authors designed the Learning Action Network (LAN), which was part of the National Initiative on Gender, Culture and Leadership in Medicine (C-Change). The LAN is a five-school consortium aimed at changing the organizational culture of its constituent institutions. The authors selected LAN schools to be geographically diverse and representative of U.S. medical schools. Institutional leaders and faculty representatives from constituent schools met twice yearly for four years (2006-2010), forming a cross-institutional learning community. Through their quarterly listing of institutional activities, schools reported a wide array of actions. Most common were increased faculty development and/or mentoring, new approaches to communication, and adoption of new policies and procedures. Other categories included data collection/management, engagement of key stakeholders, education regarding gender/diversity, and new/expanded leadership positions. Through exit interviews, most participants reported feeling optimistic about maintaining the momentum of change. However, some, especially in schools with leadership changes, expressed uncertainty. Participants reported that they felt that the LAN enabled, empowered, facilitated, and/or caused the reported actions.For others who might want to work toward changing the culture of academic medicine, the authors offer several lessons learned from their experiences with C-Change. Most notably, people, structures, policies, and reward systems must be put into place to support cultural values, and broad-based support should be created in order for changes to persist when inevitable transitions in leadership occur.

Histological analysis of the aortic nerve in the rat raised in space (Rapid communication on Neurolab Project).

PubMed

Yamasaki, M; Shimizu, T; Miyake, M; Miyamoto, Y; Waki, H; Katsuda, S I; Oishi, H; Nagayama, T; Katahira, K; Wago, H; Okochi, T; Kaneko, M; Matsumoto, S; Mukai, C; Nagaoka, S; Izumi, T; Yanagawa, K; Uemura, M; O-ishi, H

1998-11-01

To study development of the aortic nerve baroreflex under conditions of microgravity, we examined the cross section of the left aortic nerve (LAN), which is the afferent of the baroreflex, in the neonate rats aged 25 days raised in microgravity on the space shuttle Columbia (flight:FLT group) for 16 days. In this paper, we report a part of the result obtained from the data of the myelinated fibers of LAN analyzed with an electron microscope. Two kind of ground control groups were compared to the FLT group; one was asynchronous ground control (AGC) group where the rats were housed in the same cage as that on the shuttle, and the other was vivarium(VIV) group where the rats were housed in a commercial cage. The LANs in each group were extirpated the from rats perfused with a fixative and embedded for histological analysis. We observed the transverse sections of LAN and took pictures of several areas (magnified to x 2K to x 200K). No irregular myelination was found in all fibers of FLT group when they were compared with two control groups. The thickness of myelin of the maximally myelinated fibers were 0.55 +/- 0.17 micrometer in FLT(n=5), 0.45 +/- 0.10 micrometer in AGC(n=5), and O.47 +/- 0.06 micrometer meter in VIV(n=5). There was no significant difference among three groups (unpared t-test). The results suggest that there is no effect of space environment on the myelin formation of each nerve fiber in the aortic nerve.

Integrated Information Support System (IISS). Volume 4. IISS System. Part 1. System Requirements Document

DTIC Science & Technology

1990-09-30

audit trail for unauthorized entries. B.6.3.3 Manage CDM Resources B.6.3.3.1 Measure CDM Performance 1. Keep running log of CDM accesses by user types...SYSTEM SPPCIFIA OMA8MSTRTO Figure B-12. System Administrator Role B-3 1 SRD620340000 30 September 1990 4. Audit IISS hardware performance (LAN...SRD620340000 30 September 1990 7. Assist IISS service specifier and application specifier in implementing standards recommendation. 8. Perform audit of IISS

Integrated Information Support System (IISS). Volume 4. IISS System. Part 1. System Requirement Document.

DTIC Science & Technology

1985-11-01

access audit trail. 2. Screen audit trail for unauthorized entries. B.6.3.3 Manage CDX Resources B.6.3.3.1 Measure CDX Performance 1. Keep running...response time B-32 SRD620140000 1 November 1985 -ii I B -3 / I 0 / . ".3 SRD620140000 1 November 1985 4. Audit 1ISS hardware performance (LAN, HOSTS...standards on-line. 7. Assist IISS service specifier and application specifier in implementing standards recommendation. 8. Perform audit of IISS

AIIM '90: Themes and Trends.

ERIC Educational Resources Information Center

Cowan, Les

1990-01-01

Outlines and analyzes new trends and developments at the Association for Information and Image Management's 1990 spring conference. The growth of imaging and the optical storage industry is emphasized, and new developments that are discussed include hardware; optical disk drives; jukeboxes; local area networks (LANs); bar codes; image displays;…

At the Intersection of Networks and Highly Interactive Online Games

NASA Astrophysics Data System (ADS)

Armitage, Grenville

The game industry continues to evolves its techniques for extracting the most realistic 'immersion' experience for players given the vagaries on best-effort Internet service. A key challenge for service providers is understanding the characteristics of traffic imposed on networks by games, and their service quality requirements. Interactive online games are particularly susceptible to the side effects of other non-interactive (or delay- and loss-tolerant) traffic sharing next- generation access links. This creates challenges out toward the edges, where high-speed home LANs squeeze through broadband consumer access links to reach the Internet. In this chapter we identify a range of research work exploring many issues associated with the intersection of highly interactive games and the Internet, and hopefully stimulate some further thinking along these lines.

Dim light at night increases body mass of female mice.

PubMed

Aubrecht, Taryn G; Jenkins, Richelle; Nelson, Randy J

2015-05-01

During the past century, the prevalence of light at night has increased in parallel with obesity rates. Dim light at night (dLAN) increases body mass in male mice. However, the effects of light at night on female body mass remain unspecified. Thus, female mice were exposed to a standard light/dark (LD; 16 h light at ∼150 lux/8 h dark at ∼0 lux) cycle or to light/dim light at night (dLAN; 16 h light at ∼150 lux/8 h dim light at ∼5 lux) cycles for six weeks. Females exposed to dLAN increased the rate of change in body mass compared to LD mice despite reduced total food intake during weeks five and six, suggesting that dLAN disrupted circadian rhythms resulting in deranged metabolism.

A Genetic Algorithm for the Bi-Level Topological Design of Local Area Networks

PubMed Central

Camacho-Vallejo, José-Fernando; Mar-Ortiz, Julio; López-Ramos, Francisco; Rodríguez, Ricardo Pedraza

2015-01-01

Local access networks (LAN) are commonly used as communication infrastructures which meet the demand of a set of users in the local environment. Usually these networks consist of several LAN segments connected by bridges. The topological LAN design bi-level problem consists on assigning users to clusters and the union of clusters by bridges in order to obtain a minimum response time network with minimum connection cost. Therefore, the decision of optimally assigning users to clusters will be made by the leader and the follower will make the decision of connecting all the clusters while forming a spanning tree. In this paper, we propose a genetic algorithm for solving the bi-level topological design of a Local Access Network. Our solution method considers the Stackelberg equilibrium to solve the bi-level problem. The Stackelberg-Genetic algorithm procedure deals with the fact that the follower’s problem cannot be optimally solved in a straightforward manner. The computational results obtained from two different sets of instances show that the performance of the developed algorithm is efficient and that it is more suitable for solving the bi-level problem than a previous Nash-Genetic approach. PMID:26102502

Extending the Capabilities of Closed-loop Distributed Engine Control Simulations Using LAN Communication

NASA Technical Reports Server (NTRS)

Aretskin-Hariton, Eliot D.; Zinnecker, Alicia Mae; Culley, Dennis E.

2014-01-01

Distributed Engine Control (DEC) is an enabling technology that has the potential to advance the state-of-the-art in gas turbine engine control. To analyze the capabilities that DEC offers, a Hardware-In-the-Loop (HIL) test bed is being developed at NASA Glenn Research Center. This test bed will support a systems-level analysis of control capabilities in closed-loop engine simulations. The structure of the HIL emulates a virtual test cell by implementing the operator functions, control system, and engine on three separate computers. This implementation increases the flexibility and extensibility of the HIL. Here, a method is discussed for implementing these interfaces by connecting the three platforms over a dedicated Local Area Network (LAN). This approach is verified using the Commercial Modular Aero-Propulsion System Simulation 40k (C-MAPSS40k), which is typically implemented on one computer. There are marginal differences between the results from simulation of the typical and the three-computer implementation. Additional analysis of the LAN network, including characterization of network load, packet drop, and latency, is presented. The three-computer setup supports the incorporation of complex control models and proprietary engine models into the HIL framework.

Fiber optic TV direct

NASA Technical Reports Server (NTRS)

Kassak, John E.

1991-01-01

The objective of the operational television (OTV) technology was to develop a multiple camera system (up to 256 cameras) for NASA Kennedy installations where camera video, synchronization, control, and status data are transmitted bidirectionally via a single fiber cable at distances in excess of five miles. It is shown that the benefits (such as improved video performance, immunity from electromagnetic interference and radio frequency interference, elimination of repeater stations, and more system configuration flexibility) can be realized if application of the proven fiber optic transmission concept is used. The control system will marry the lens, pan and tilt, and camera control functions into a modular based Local Area Network (LAN) control network. Such a system does not exist commercially at present since the Television Broadcast Industry's current practice is to divorce the positional controls from the camera control system. The application software developed for this system will have direct applicability to similar systems in industry using LAN based control systems.

CHARACTERIZING SPATIAL AND TEMPORAL DYNAMICS: DEVELOPMENT OF A GRID-BASED WATERSHED MERCURY LOADING MODEL

EPA Science Inventory

A distributed grid-based watershed mercury loading model has been developed to characterize spatial and temporal dynamics of mercury from both point and non-point sources. The model simulates flow, sediment transport, and mercury dynamics on a daily time step across a diverse lan...

SDN architecture for optical packet and circuit integrated networks

NASA Astrophysics Data System (ADS)

Furukawa, Hideaki; Miyazawa, Takaya

2016-02-01

We have been developing an optical packet and circuit integrated (OPCI) network, which realizes dynamic optical path, high-density packet multiplexing, and flexible wavelength resource allocation. In the OPCI networks, a best-effort service and a QoS-guaranteed service are provided by employing optical packet switching (OPS) and optical circuit switching (OCS) respectively, and users can select these services. Different wavelength resources are assigned for OPS and OCS links, and the amount of their wavelength resources are dynamically changed in accordance with the service usage conditions. To apply OPCI networks into wide-area (core/metro) networks, we have developed an OPCI node with a distributed control mechanism. Moreover, our OPCI node works with a centralized control mechanism as well as a distributed one. It is therefore possible to realize SDN-based OPCI networks, where resource requests and a centralized configuration are carried out. In this paper, we show our SDN architecture for an OPS system that configures mapping tables between IP addresses and optical packet addresses and switching tables according to the requests from multiple users via a web interface. While OpenFlow-based centralized control protocol is coming into widespread use especially for single-administrative, small-area (LAN/data-center) networks. Here, we also show an interworking mechanism between OpenFlow-based networks (OFNs) and the OPCI network for constructing a wide-area network, and a control method of wavelength resource selection to automatically transfer diversified flows from OFNs to the OPCI network.

All-optical LAN architectures based on arrayed waveguide grating multiplexers

NASA Astrophysics Data System (ADS)

Woesner, Hagen

1998-10-01

The paper presents optical LAN topologies which are made possible using an Arrayed Waveguide Grating Multiplexer (AWGM) instead of a passive star coupler to interconnect stations in an all-optical LAN. Due to the collision-free nature of an AWGM it offers the n-fold bandwidth compared to the star coupler. Virtual ring topologies appear (one ring on each wavelength) if the number of stations attached to the AWGM is a prime number. A method to construct larger networks using Cayley graphs is shown. An access protocol to avoid collisions on the proposed network is outlined.

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.

PubMed

Tam, Heng Keat; Härle, Johannes; Gerhardt, Stefan; Rohr, Jürgen; Wang, Guojun; Thorson, Jon S; Bigot, Aurélien; Lutterbeck, Monika; Seiche, Wolfgang; Breit, Bernhard; Bechthold, Andreas; Einsle, Oliver

2015-02-23

The structures of the O-glycosyltransferase LanGT2 and the engineered, C-C bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhydrolyzable nucleotide-sugar analogue revealed that there is a conformational transition to create the binding sites for the aglycon substrate. This induced-fit transition was explored by molecular docking experiments with various aglycon substrates. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Serial Network Flow Monitor

NASA Technical Reports Server (NTRS)

Robinson, Julie A.; Tate-Brown, Judy M.

2009-01-01

Using a commercial software CD and minimal up-mass, SNFM monitors the Payload local area network (LAN) to analyze and troubleshoot LAN data traffic. Validating LAN traffic models may allow for faster and more reliable computer networks to sustain systems and science on future space missions. Research Summary: This experiment studies the function of the computer network onboard the ISS. On-orbit packet statistics are captured and used to validate ground based medium rate data link models and enhance the way that the local area network (LAN) is monitored. This information will allow monitoring and improvement in the data transfer capabilities of on-orbit computer networks. The Serial Network Flow Monitor (SNFM) experiment attempts to characterize the network equivalent of traffic jams on board ISS. The SNFM team is able to specifically target historical problem areas including the SAMS (Space Acceleration Measurement System) communication issues, data transmissions from the ISS to the ground teams, and multiple users on the network at the same time. By looking at how various users interact with each other on the network, conflicts can be identified and work can begin on solutions. SNFM is comprised of a commercial off the shelf software package that monitors packet traffic through the payload Ethernet LANs (local area networks) on board ISS.

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

PubMed Central

Jones, Therésa M.; Durrant, Joanna; Michaelides, Ellie B.; Green, Mark P.

2015-01-01

The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key driver of biological rhythm and a potent antioxidant with a proposed role in immune function. Here, we briefly review the evidence for melatonin as the link between LAN and changes in behaviour and physiology. We then present preliminary data supporting the potential for melatonin to act as a recovery agent mitigating the negative effects of LAN in an invertebrate. Adult crickets (Teleogryllus commodus), exposed to constant illumination, were provided with dietary melatonin (concentrations: 0, 10 or 100 µg ml−1) in their drinking water. We then compared survival, lifetime fecundity and, over a 4-week period, immune function (haemocyte concentration, lysozyme-like and phenoloxidase (PO) activity). Melatonin supplementation was able only partially to mitigate the detrimental effects of LAN: it did not improve survival or fecundity or PO activity, but it had a largely dose-dependent positive effect on haemocyte concentration and lysozyme-like activity. We discuss the implications of these relationships, as well as the usefulness of invertebrates as model species for future studies that explore the effects of LAN. PMID:25780235

Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts.

PubMed

Wu, Jinghai; Dauchy, Robert T; Tirrell, Paul C; Wu, Steven S; Lynch, Darin T; Jitawatanarat, Potjana; Burrington, Christine M; Dauchy, Erin M; Blask, David E; Greene, Michael W

2011-04-01

Regulation of diurnal and circadian rhythms and cell proliferation are coupled in all mammals, including humans. However, the molecular mechanisms by which diurnal and circadian rhythms regulate cell proliferation are relatively poorly understood. In this study, we report that tumor growth in nude rats bearing human steroid receptor-negative MCF-7 breast tumors can be significantly accelerated by exposing the rats to light at night (LAN). Under normal conditions of an alternating light/dark cycle, proliferating cell nuclear antigen (PCNA) levels in tumors were maximal in the early light phase but remained at very low levels throughout the daily 24-hour cycle period monitored. Surprisingly, PCNA was expressed in tumors continually at a high level throughout the entire 24-hour period in LAN-exposed nude rats. Daily fluctuations of Akt and mitogen activated protein kinase activation in tumors were also disrupted by LAN. These fluctuations did not track with PCNA changes, but we found that activation of the Akt stimulatory kinase phosphoinositide-dependent protein kinase 1 (PDK1) directly correlated with PCNA levels. Expression of insulin-like growth factor 1 receptor (IGF-1R), an upstream signaling molecule for PDK1, also correlated with fluctuations of PDK1/PCNA in the LAN group. In addition, circulating IGF-1 concentrations were elevated in LAN-exposed tumor-bearing nude rats. Finally, RNAi-mediated knockdown of PDK1 led to a reduction in PCNA expression and cell proliferation in vitro and tumor growth in vivo, indicating that PDK1 regulates breast cancer growth in a manner correlated with PCNA expression. Taken together, our findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling.

Network time synchronization servers at the US Naval Observatory

NASA Technical Reports Server (NTRS)

Schmidt, Richard E.

1995-01-01

Responding to an increased demand for reliable, accurate time on the Internet and Milnet, the U.S. Naval Observatory Time Service has established the network time servers, tick.usno.navy.mil and tock.usno.navy.mil. The system clocks of these HP9000/747i industrial work stations are synchronized to within a few tens of microseconds of USNO Master Clock 2 using VMEbus IRIG-B interfaces. Redundant time code is available from a VMEbus GPS receiver. UTC(USNO) is provided over the network via a number of protocols, including the Network Time Protocol (NTP) (DARPA Network Working Group Report RFC-1305), the Daytime Protocol (RFC-867), and the Time protocol (RFC-868). Access to USNO network time services is presently open and unrestricted. An overview of USNO time services and results of LAN and WAN time synchronization tests will be presented.

Phytoplankton Imaging and Analysis System: Instrumentation for Field and Laboratory Acquisition, Analysis and WWW/LAN-Based Sharing of Marine Phytoplankton Data (DURIP)

DTIC Science & Technology

2000-09-30

networks (LAN), (3) quantifying size, shape, and other parameters of plankton cells and colonies via image analysis and image reconstruction, and (4) creating educational materials (e.g. lectures, videos etc.).

A LAN Primer.

ERIC Educational Resources Information Center

Hazari, Sunil I.

1991-01-01

Local area networks (LANs) are systems of computers and peripherals connected together for the purposes of electronic mail and the convenience of sharing information and expensive resources. In planning the design of such a system, the components to consider are hardware, software, transmission media, topology, operating systems, and protocols.…

Multimedia on the Network: Has Its Time Come?

ERIC Educational Resources Information Center

Galbreath, Jeremy

1995-01-01

Examines the match between multimedia data and local area network (LAN) infrastructures. Highlights include applications for networked multimedia, i.e., asymmetric and symmetric; alternate LAN technology, including stream management software, Ethernet, FDDI (Fiber Distributed Data Interface), and ATM (Asynchronous Transfer Mode); WAN (Wide Area…

Projective limits of state spaces II. Quantum formalism

NASA Astrophysics Data System (ADS)

Lanéry, Suzanne; Thiemann, Thomas

2017-06-01

In this series of papers, we investigate the projective framework initiated by Kijowski (1977) and Okołów (2009, 2014, 2013), which describes the states of a quantum theory as projective families of density matrices. A short reading guide to the series can be found in Lanéry (2016). After discussing the formalism at the classical level in a first paper (Lanéry, 2017), the present second paper is devoted to the quantum theory. In particular, we inspect in detail how such quantum projective state spaces relate to inductive limit Hilbert spaces and to infinite tensor product constructions (Lanéry, 2016, subsection 3.1) [1]. Regarding the quantization of classical projective structures into quantum ones, we extend the results by Okołów (2013), that were set up in the context of linear configuration spaces, to configuration spaces given by simply-connected Lie groups, and to holomorphic quantization of complex phase spaces (Lanéry, 2016, subsection 2.2) [1].

Space Flight Operations Center local area network

NASA Technical Reports Server (NTRS)

Goodman, Ross V.

1988-01-01

The existing Mission Control and Computer Center at JPL will be replaced by the Space Flight Operations Center (SFOC). One part of the SFOC is the LAN-based distribution system. The purpose of the LAN is to distribute the processed data among the various elements of the SFOC. The SFOC LAN will provide a robust subsystem that will support the Magellan launch configuration and future project adaptation. Its capabilities include (1) a proven cable medium as the backbone for the entire network; (2) hardware components that are reliable, varied, and follow OSI standards; (3) accurate and detailed documentation for fault isolation and future expansion; and (4) proven monitoring and maintenance tools.

Ubiquitous Computing for Remote Cardiac Patient Monitoring: A Survey

PubMed Central

Kumar, Sunil; Kambhatla, Kashyap; Hu, Fei; Lifson, Mark; Xiao, Yang

2008-01-01

New wireless technologies, such as wireless LAN and sensor networks, for telecardiology purposes give new possibilities for monitoring vital parameters with wearable biomedical sensors, and give patients the freedom to be mobile and still be under continuous monitoring and thereby better quality of patient care. This paper will detail the architecture and quality-of-service (QoS) characteristics in integrated wireless telecardiology platforms. It will also discuss the current promising hardware/software platforms for wireless cardiac monitoring. The design methodology and challenges are provided for realistic implementation. PMID:18604301

Ubiquitous computing for remote cardiac patient monitoring: a survey.

PubMed

Kumar, Sunil; Kambhatla, Kashyap; Hu, Fei; Lifson, Mark; Xiao, Yang

2008-01-01

New wireless technologies, such as wireless LAN and sensor networks, for telecardiology purposes give new possibilities for monitoring vital parameters with wearable biomedical sensors, and give patients the freedom to be mobile and still be under continuous monitoring and thereby better quality of patient care. This paper will detail the architecture and quality-of-service (QoS) characteristics in integrated wireless telecardiology platforms. It will also discuss the current promising hardware/software platforms for wireless cardiac monitoring. The design methodology and challenges are provided for realistic implementation.

The 10 Hottest Technologies in Telecom.

ERIC Educational Resources Information Center

Flanagan, Patrick

1996-01-01

Synthesizes opinions of experts regarding technologies deemed most likely to enter the telecommunications mainstream by 1998, including: (1) the Java programming language; (2) voice- over frame relay; (3) virtual local area networks (LANs); (4) cable modems; (5) gigabit LANs; (6) Internet appliances; (7) personal satellite phones; (8) intranets;…

Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide.

PubMed

Fonken, Laura K; Weil, Zachary M; Nelson, Randy J

2013-11-01

The mammalian circadian system regulates many physiological functions including inflammatory responses. Appropriately timed light information is essential for maintaining circadian organization. Over the past ∼120 years, urbanization and the widespread adoption of electric lights have dramatically altered lighting environments. Exposure to light at night (LAN) is pervasive in modern society and disrupts core circadian clock mechanisms. Because microglia are the resident macrophages in the brain and macrophages contain intrinsic circadian clocks, we hypothesized that chronic exposure to LAN would alter microglia cytokine expression and sickness behavior following LPS administration. Exposure to 4 weeks of dim LAN elevated inflammatory responses in mice. Mice exposed to dimly lit, as compared to dark, nights exaggerated changes in body temperature and elevated microglia pro-inflammatory cytokine expression following LPS administration. Furthermore, dLAN mice had a prolonged sickness response following the LPS challenge. Mice exposed to dark or dimly lit nights had comparable sickness behavior directly following the LPS injection; however, dLAN mice showed greater reductions in locomotor activity, increased anorectic behavior, and increased weight loss than mice maintained in dark nights 24h post-LPS injection. Overall, these data suggest that chronic exposure to even very low levels of light pollution may alter inflammatory responses. These results may have important implications for humans and other urban dwelling species that commonly experience nighttime light exposure. Copyright © 2013 Elsevier Inc. All rights reserved.

Attacks on Bluetooth Security Architecture and Its Countermeasures

NASA Astrophysics Data System (ADS)

Iqbal, Mian Muhammad Waseem; Kausar, Firdous; Wahla, Muhammad Arif

WPANs compliment the traditional IEEE 802.11 wireless networks by facilitating the clients with flexibility in network topologies, higher mobility and relaxed configuration/hardware requirements. Bluetooth, a WPAN technology, is an open standard for short-range radio frequency (RF) communication. However, it is also susceptible to typical security threats found in wireless LANs. This paper discuses some of the attack scenarios against the bluetooth network such as hostile intrusion, active Man-in-the-Middle (MITM) attack using unit key and various forms of denial of service (DoS) attacks. These threats and attacks compromise the confidentiality and availability of bluetooth data and services. This paper proposes an improved security architecture for bluetooth device which provides protection against the above mentioned attacks.

Advanced Map For Real-Time Process Control

NASA Astrophysics Data System (ADS)

Shiobara, Yasuhisa; Matsudaira, Takayuki; Sashida, Yoshio; Chikuma, Makoto

1987-10-01

MAP, a communications protocol for factory automation proposed by General Motors [1], has been accepted by users throughout the world and is rapidly becoming a user standard. In fact, it is now a LAN standard for factory automation. MAP is intended to interconnect different devices, such as computers and programmable devices, made by different manufacturers, enabling them to exchange information. It is based on the OSI intercomputer com-munications protocol standard under development by the ISO. With progress and standardization, MAP is being investigated for application to process control fields other than factory automation [2]. The transmission response time of the network system and centralized management of data exchanged with various devices for distributed control are import-ant in the case of a real-time process control with programmable controllers, computers, and instruments connected to a LAN system. MAP/EPA and MINI MAP aim at reduced overhead in protocol processing and enhanced transmission response. If applied to real-time process control, a protocol based on point-to-point and request-response transactions limits throughput and transmission response. This paper describes an advanced MAP LAN system applied to real-time process control by adding a new data transmission control that performs multicasting communication voluntarily and periodically in the priority order of data to be exchanged.

Interoceanic variation in the rare earth, major, and trace element depositional chemistry of chert: Perspectives gained from the DSDP and ODP record

USGS Publications Warehouse

Murray, R.W.; Buchholtz ten Brink, Marilyn R.; Gerlach, David C.; Russ III, G. Price; Jones, David L.

1992-01-01

Rare earth element (REE), major, and trace element abundances and relative fractionations in forty nodular cherts sampled by the Deep Sea Drilling Project (DSDP) and Ocean Drilling Program (ODP) indicate that the REE composition of chert records the interplay between terrigenous sources and scavenging from the local seawater. Major and (non-REE) trace element ratios indicate that the aluminosilicate fraction within the chert is similar to NASC (North American Shale Composite), with average Pacific chert including ~7% NASC-like particles, Indian chert ~ 11% NASC, Atlantic chert ~ 17% NASC, and southern high latitude (SHL) chert 53% NASC. Using La as a proxy for ∑REE, approximations of Laex (the amount of La in excess of that supplied by the detrital aluminosilicate fraction) indicate that Pacific chert contains the greatest Laex (85% of Latotal) and SHL chert the least (38% of Latotal). As shown by interelement associations, this Laex is most likely an adsorbed component onto aluminosilicate and phosphatic phases.Accordingly, chert from the large Pacific Ocean, where deposition occurs relatively removed from significant terrigenous input, records a depositional REE signal dominated by adsorption of dissolved REEs from seawater. Pacific chert CeCe*⪡ 1 and LanYbn ~ 0.8-1, resulting from adsorption of local Ce-depleted seawater and preferential adsorption of LREEs from seawater (e.g., LanYbn ~ 0.4), which increases the LanYbn ratio recorded in chert. Chert from the Atlantic basin, a moderately sized ocean basin lined by passive margins and with more terrigenous input than the Pacific, records a mix of adsorptive and terrigenous REE signals, with moderately negative Ce anomalies and LanYbn">LanYbn ratios intermediate to those of the Pacific and those of terrigenous input. Chert from the SHL region is dominated by the large terrigenous input on the Antarctic passive margin, with inherited CeCe*~1">CeCe*~1 and inherited LanYbn">LanYbn values of ~1.2–1.4.CeCe*">~1.2–1.4.CeCe* does not vary with age, either throughout the entire data base or within a particular basin. Overall, CeCe*">CeCe* does not correlate with P2O5 concentrations, even though phosphatic phases may be an important REE carrier.This and previous studies of the large-scale controlling parameters of sedimentary REEs across ocean basins collectively indicate that REE indices of depositional regime (e.g., CeCe*">CeCe*, LanYbn">LanYbn, Laex) are reproducible in a variety of sediment and rock lithologies, ages, and ocean basins, and present a coherent tool for paleoceanographic and tectonic basin reconstructions.

Somatostatin receptor PET in neuroendocrine tumours: 68Ga-DOTA0,Tyr3-octreotide versus 68Ga-DOTA0-lanreotide.

PubMed

Putzer, Daniel; Kroiss, Alexander; Waitz, Dietmar; Gabriel, Michael; Traub-Weidinger, Tatjana; Uprimny, Christian; von Guggenberg, Elisabeth; Decristoforo, Clemens; Warwitz, Boris; Widmann, Gerlig; Virgolini, Irene Johanna

2013-02-01

The aim of this study was to evaluate the impact of (68)Ga-labelled DOTA(0)-lanreotide ((68)Ga-DOTA-LAN) on the diagnostic assessment of neuroendocrine tumour (NET) patients with low to moderate uptake on planar somatostatin receptor (SSTR) scintigraphy or (68)Ga-labelled DOTA(0),Tyr(3)-octreotide ((68)Ga-DOTA-TOC) positron emission tomography (PET). Fifty-three patients with histologically confirmed NET and clinical signs of progressive disease, who had not qualified for peptide receptor radionuclide therapy (PRRT) on planar SSTR scintigraphy or (68)Ga-DOTA-TOC PET (n = 38) due to lack of tracer uptake, underwent (68)Ga-DOTA-LAN PET to evaluate a treatment option with (90)Y-labelled lanreotide according to the MAURITIUS trial. The included patients received 150 ± 30 MBq of each radiopharmaceutical intravenously. PET scans were acquired 60-90 min after intravenous bolus injection. Image results from both PET scans were compared head to head, focusing on the intensity of tracer uptake in terms of treatment decision. CT was used for morphologic correlation of tumour lesions. To further evaluate the binding affinities of each tracer, quantitative and qualitative values were calculated for target lesions. (68)Ga-DOTA-LAN and (68)Ga-DOTA-TOC both showed equivalent findings in 24/38 patients when fused PET/CT images were interpreted. The sensitivity, specificity and accuracy of (68)Ga-DOTA-LAN in comparison to CT were 0.63, 0.5 and 0.62 (n = 53; p < 0.0001) and for (68)Ga-DOTA-TOC in comparison to CT 0.78, 0.5 and 0.76 (n = 38; p < 0.013), respectively. (68)Ga-DOTA-TOC showed a significantly higher maximum standardized uptake value (SUV(max)) regarding the primary tumour in 25 patients (p < 0.003) and regarding the liver in 30 patients (p < 0.009) compared to (68)Ga-DOTA-LAN. Corresponding values of both PET scans for tumour and liver did not show any significant correlation. (68)Ga-DOTA-TOC revealed more tumour sites than (68)Ga-DOTA-LAN (106 vs 53). The tumour to background ratios for tumour and liver calculated from SUV(max) measurements were significantly higher for (68)Ga-DOTA-TOC than (68)Ga-DOTA-LAN (p < 0.02). (68)Ga-DOTA-TOC PET imaging is an established imaging procedure for accurate staging of NET patients. (68)Ga-DOTA-LAN should only be considered as a PET tracer of second choice in patients with no pathologic tracer uptake on (68)Ga-DOTA-TOC PET. In these patients, (68)Ga-DOTA-LAN PET can provide valuable information when evaluating PRRT as the treatment option, as a broader spectrum of human SSTR subtypes can be detected.

Security Engineering Lessons Learned for Migrating Independent LANs to an Enterprise Environment

ERIC Educational Resources Information Center

Marchant, Robert L.; Bonneau, Thomas

2013-01-01

Transition from small, independent LANs into larger enterprise managed infrastructures is becoming more prominent in academia, business and government. Consolidation of IT resources into larger, more disciplined, and more professionally managed environments has significant advantages however they do bring their own unique issues to solve in order…

Implementation of a real-time multi-channel gateway server in ubiquitous integrated biotelemetry system for emergency care (UIBSEC).

PubMed

Cheon, Gyeongwoo; Shin, Il Hyung; Jung, Min Yang; Kim, Hee Chan

2009-01-01

We developed a gateway server to support various types of bio-signal monitoring devices for ubiquitous emergency healthcare in a reliable, effective, and scalable way. The server provides multiple channels supporting real-time N-to-N client connections. We applied our system to four types of health monitoring devices including a 12-channel electrocardiograph (ECG), oxygen saturation (SpO(2)), and medical imaging devices (a ultrasonograph and a digital skin microscope). Different types of telecommunication networks were tested: WIBRO, CDMA, wireless LAN, and wired internet. We measured the performance of our system in terms of the transmission rate and the number of simultaneous connections. The results show that the proposed network communication strategy can be successfully applied to the ubiquitous emergency healthcare service by providing a fast rate enough for real-time video transmission and multiple connections among patients and medical personnel.

Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLANS) Project.

USDA-ARS?s Scientific Manuscript database

The International Lipid-Based Nutrient Supplements (iLiNS) Project began in 2009 with the goal of contributing to the evidence base regarding the potential of lipid-based nutrient supplements (LNS) to prevent undernutrition in vulnerable populations. The first project objective was the development o...

Shared virtual environments for telerehabilitation.

PubMed

Popescu, George V; Burdea, Grigore; Boian, Rares

2002-01-01

Current VR telerehabilitation systems use offline remote monitoring from the clinic and patient-therapist videoconferencing. Such "store and forward" and video-based systems cannot implement medical services involving patient therapist direct interaction. Real-time telerehabilitation applications (including remote therapy) can be developed using a shared Virtual Environment (VE) architecture. We developed a two-user shared VE for hand telerehabilitation. Each site has a telerehabilitation workstation with a videocamera and a Rutgers Master II (RMII) force feedback glove. Each user can control a virtual hand and interact hapticly with virtual objects. Simulated physical interactions between therapist and patient are implemented using hand force feedback. The therapist's graphic interface contains several virtual panels, which allow control over the rehabilitation process. These controls start a videoconferencing session, collect patient data, or apply therapy. Several experimental telerehabilitation scenarios were successfully tested on a LAN. A Web-based approach to "real-time" patient telemonitoring--the monitoring portal for hand telerehabilitation--was also developed. The therapist interface is implemented as a Java3D applet that monitors patient hand movement. The monitoring portal gives real-time performance on off-the-shelf desktop workstations.

Propagation Characteristics in an Underground Shopping Area for 5GHz-band Wireless Access Systems

NASA Astrophysics Data System (ADS)

Itokawa, Kiyohiko; Kita, Naoki; Sato, Akio; Matsue, Hideaki; Mori, Daisuke; Watanabe, Hironobu

5-GHz band wireless access systems, such as the RLAN (Radio Local Area Network) system of IEEE802.11a, HiperLAN/2, HiSWANa and AWA, are developed and provide transmission rates over 20 Mbps for indoor use. Those 5-GHz access systems are expected to extend service areas from the office to the so-called “hot-spot" in public areas. Underground shopping malls are one of the anticipated service areas for such a nomadic wireless access service. Broadband propagation characteristics are required for radio zone design in an underground mall environment despite previous results obtained by narrow band measurements. This paper presents results of an experimental study on the propagation characteristics for broadband wireless access systems in an underground mall environment. First, broadband propagation path loss is measured and formulated considering human body shadowing. A ray trace simulation is used to clarify the basic propagation mechanism in such a closed environment. Next, a distance dependency of the delay spread during a crowded time period, rush hour, is found to be at most 65 nsec, which is under the permitted maximum value of the present 5-GHz systems. Finally, above propagation characteristics support the result of transmission test carried out by using AWA equipment.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bobyshev, A.; DeMar, P.; Grigaliunas, V.

The LHC is entering its fourth year of production operation. Most Tier1 facilities have been in operation for almost a decade, when development and ramp-up efforts are included. LHC's distributed computing model is based on the availability of high capacity, high performance network facilities for both the WAN and LAN data movement, particularly within the Tier1 centers. As a result, the Tier1 centers tend to be on the leading edge of data center networking technology. In this paper, we analyze past and current developments in Tier1 LAN networking, as well as extrapolating where we anticipate networking technology is heading. Ourmore » analysis will include examination into the following areas: Evolution of Tier1 centers to their current state Evolving data center networking models and how they apply to Tier1 centers Impact of emerging network technologies (e.g. 10GE-connected hosts, 40GE/100GE links, IPv6) on Tier1 centers Trends in WAN data movement and emergence of software-defined WAN network capabilities Network virtualization« less

Protocol and Topology Issues for Wide-Area Satellite Interconnection of Terrestrial Optical LANs

NASA Astrophysics Data System (ADS)

Parraga, N.

2002-01-01

Apart from broadcasting, the satellite business is targeting niche markets. Wide area interconnection is considered as one of these niche markets, since it addresses operators and business LANs (B2B, business to business) in remote areas where terrestrial infrastructure is not available. These LANs - if high-speed - are typically based on optical networks such as SONET. One of the advantages of SONET is its architecture flexibility and capacity to transport all kind of applications including multimedia with a range of different transmission rates. The applications can be carried by different protocols among which the Internet Protocol (IP) or the Asynchronous Transfer Mode (ATM) are the most prominent ones. Thus, the question arises how these protocols can be interconnected via the satellite segment. The paper addresses several solutions for interworking with different protocols. For this investigation we distinguish first of all between the topology and the switching technology of the satellites. In case of a star network with transparent satellite, the satellite protocol consists of physical layer and data layer which can be directly interconnected with layer 2 interworking function to their terrestrial counterparts in the SONET backbone. For regenerative satellites the situation is more complex: here we need to distinguish the types of transport protocols being used in the terrestrial and satellite segment. Whereas IP, ATM, MPEG dominate in the terrestrial networks, satellite systems usually do not follow these standards. Some might employ minor additions (for instance, satellite specific packet headers), some might be completely proprietary. In general, interworking must be done for the data plane on top of layer 2 (data link layer), whereas for the signaling plane the interworking is on top of layer 3. In the paper we will discuss the protocol stacks for ATM, IP, and MPEG with a regenerative satellite system. As an example we will use the EuroSkyWay satellite system for multimedia services. EuroSkyWay uses a GEO satellite with onboard switching. It has its own proprietary protocol stack for data link control (DLC), logical link control (LLC) and layer 3 functions such as resource management, call admission control and authentication. Special attention is paid to the IP interworking with Layer 3 function since IP does not support connection set-up and session protocols, thus proper interworking functions with IP signaling protocols for resource reservation routing such as RSVP, BGP, and ICMP need to be developed. Whereas the EuroSkyWay system is an representative for a meshed topology, DVB-RCS systems have usually star configuration with a central hub station. Different data streams are distinguished by program identifiers (PIDs). Recent proposals aim at the evolution of DVB-RCS towards a fully meshed structure. The paper will also discuss the protocol architecture for interconnect SONET LANs over these systems. Finally, a performance comparison of the different solutions will be given in terms of cell overhead rate and signalling effort for selected scenarios.

The Business Education Lab and Local Area Networking for Curriculum Improvement.

ERIC Educational Resources Information Center

Seals, Georgina; And Others

This guide explains how to incorporate a local area network (LAN) into the business education curriculum. The first section defines LAN, a communications system that links computers and other peripherals within an office or throughout nearby buildings and shares multiuser software and send and/or receive information. Curriculum planning…

Local Area Networks in Education: Overview, Applications, and Current Limitations.

ERIC Educational Resources Information Center

Piele, Philip K.

Local area networks (LAN) are privately owned communication systems that connect multivendor devices at high speed. As microcomputers become more common in schools, user interest in sharing information, software, and peripherals will increase. A basic understanding of the operation of all LAN's can be gained by knowing four elements: media,…

Anti-Reflection Characteristics of Si Nanowires for Enhanced Photoluminescence from CdTe/CdS Quantum Dots

NASA Astrophysics Data System (ADS)

Wang, Hong-Yu; Shan, Dan; Xu, Ling

2018-05-01

Not Available Supported by the Qing Lan Project of the Higher Education Institutions of Jiangsu Province, Qing Lan Project of Yangzhou Polytechnic Institute, the Natural Science Foundation of Yangzhou City under Grant No YZ2016123, and the National Natural Science Foundation of China under Grant No 61376004.

GLOBECOM '85 - Global Telecommunications Conference, New Orleans, LA, December 2-5, 1985, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Various papers on global telecommunications are presented. The general topics addressed include: multiservice integration with optical fibers, multicompany owned telecommunication networks, softworks quality and reliability, advanced on-board processing, impact of new services and systems on operations and maintenance, analytical studies of protocols for data communication networks, topics in packet radio networking, CCITT No. 7 to support new services, document processing and communication, antenna technology and system aspects in satellite communications. Also considered are: communication systems modelling methodology, experimental integrated local area voice/data nets, spread spectrum communications, motion video at the DS-0 rate, optical and data communications, intelligent work stations, switch performance analysis, novel radio communication systems, wireless local networks, ISDN services, LAN communication protocols, user-system interface, radio propagation and performance, mobile satellite system, software for computer networks, VLSI for ISDN terminals, quality management, man-machine interfaces in switching, and local area network performance.

Electronic and mechanical properties of 5d transition metal mononitrides via first principles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao Erjun; Graduate School, Chinese Academy of Sciences, Beijing 100049; Wu Zhijian

2008-10-15

The electronic and mechanical properties of 5d transition metal mononitrides from LaN to AuN are systematically investigated by use of the density-functional theory. For each nitride, six structures are considered, i.e., rocksalt, zinc blende, CsCl, wurtzite, NiAs and WC structures. Among the considered structures, rocksalt structure is the most stable for LaN, HfN and AuN, WC structure for TaN, NiAs structure for WN, wurtzite structure for ReN, OsN, IrN and PtN. The most stable structure for each nitride is mechanically stable. The formation enthalpy increases from LaN to AuN. For LaN, HfN and TaN, the formation enthalpy is negative formore » all the considered structures, while from WN to AuN, except wurtzite structure in ReN, the formation enthalpy is positive. The calculated density of states shows that they are all metallic. ReN in NiAs structure has the largest bulk modulus, 418 GPa. The largest shear modulus 261 GPa is from TaN in WC structure. Trends are discussed. - Graphical abstract: Formation enthalpy per formula unit {delta}H (eV) for all the considered structures of 5d transition metal mononitrides MN (M=La-Au). It was shown that the formation enthalpy increases from LaN to AuN. The nitrides with negative values indicate that they can be synthesized experimentally at ambient conditions.« less

A WATERSHED-LEVEL APPROACH TO STUDY THE PUTATIVE RELATIONSHIPS BETWEEN LANDUSE CHANGE AND SURFACE WATER FLOW ALTERATION

EPA Science Inventory

Inter-generationally prudent management of watershed resources will require attention to the interdependence between shifting landuse distributions and their effects on watershed hydrology. Development and increased proportion of impervious surface area has been found to alte lan...

A Framework for Applying Asynchronous Transfer Mode (ATM) Technology to Command, Control and Communications Systems

DTIC Science & Technology

1994-06-01

available they can be implemented in ATM LANs by using different reserved signaling channels ( Biagioni , Cooper, and Sansom, 1993, p. 35). An argument...conference, San Francisco, California, 12-14 April 1994. Biagioni , E., Cooper, E. and Sansom, R., "Designing a Practical ATM LAN", IEEE Network, v. 7, March

Interview with Datin Goh Suet Lan on Business Coaching

ERIC Educational Resources Information Center

Nimehchisalem, Vahid

2016-01-01

In this article the author writes of having had the pleasure of meeting Datin Goh Suet Lan and one of the key members of her team, Mr. Murali, in the Faculty of Modern Languages and Communication, Universiti Putra Malaysia with three colleagues, Associate Professor Dr. Shamala Paramasivam (who initiated this meeting), Dr. Ilyana Binti Jalaluddin,…

Numerical Simulations of Homogeneous Turbulence Using Lagrangian-Averaged Navier-Stokes Equations

NASA Technical Reports Server (NTRS)

Mohseni, Kamran; Shkoller, Steve; Kosovic, Branko; Marsden, Jerrold E.; Carati, Daniele; Wray, Alan; Rogallo, Robert

2000-01-01

The Lagrangian-averaged Navier-Stokes (LANS) equations are numerically evaluated as a turbulence closure. They are derived from a novel Lagrangian averaging procedure on the space of all volume-preserving maps and can be viewed as a numerical algorithm which removes the energy content from the small scales (smaller than some a priori fixed spatial scale alpha) using a dispersive rather than dissipative mechanism, thus maintaining the crucial features of the large scale flow. We examine the modeling capabilities of the LANS equations for decaying homogeneous turbulence, ascertain their ability to track the energy spectrum of fully resolved direct numerical simulations (DNS), compare the relative energy decay rates, and compare LANS with well-accepted large eddy simulation (LES) models.

Software Engineering Techniques for Computer-Aided Learning.

ERIC Educational Resources Information Center

Ibrahim, Bertrand

1989-01-01

Describes the process for developing tutorials for computer-aided learning (CAL) using a programing language rather than an authoring system. The workstation used is described, the use of graphics is discussed, the role of a local area network (LAN) is explained, and future plans are discussed. (five references) (LRW)

An Archive of Digital Images.

ERIC Educational Resources Information Center

Fantini, M.; And Others

1990-01-01

Describes the architecture of the prototype of an image management system that has been used to develop an application concerning images of frescoes in the Sistina Chapel in the Vatican. Hardware and software design are described, the use of local area networks (LANs) is discussed, and data organization is explained. (15 references) (LRW)

Automated Bilingual Circulation System Using PC Local Area Networks.

ERIC Educational Resources Information Center

Iskanderani, A. I.; Anwar, M. A.

1992-01-01

Describes a personal computer and LAN-based automated circulation system capable of handling both Arabic and Latin characters that was developed for use at King Abdullaziz University (Jeddah, Saudi Arabia). Outlines system requirements, system structure, hardware needs, and individual functional modules of the system. Numerous examples and flow…

Prototype system of secure VOD

NASA Astrophysics Data System (ADS)

Minemura, Harumi; Yamaguchi, Tomohisa

1997-12-01

Secure digital contents delivery systems are to realize copyright protection and charging mechanism, and aim at secure delivery service of digital contents. Encrypted contents delivery and history (log) management are means to accomplish this purpose. Our final target is to realize a video-on-demand (VOD) system that can prevent illegal usage of video data and manage user history data to achieve a secure video delivery system on the Internet or Intranet. By now, mainly targeting client-server systems connected with enterprise LAN, we have implemented and evaluated a prototype system based on the investigation into the delivery method of encrypted video contents.

Small ICBM Area Narrowing Report. Volume 1. Hard Mobile Launcher in Random Movement Basing Mode

DTIC Science & Technology

1986-01-01

WHICH STATE INSTALLATION SERVICE ELIMINATED DE DOVER AIR FORCE BASE AF 4 DE REC AREA, FIRST ARMY ARMY 3 FL AVON PARK AIR FORCE RANGE AF 3 FL CAPE...PLANT NO. 47 AF 3 OH COLUMBUS DEF CONST SUPPLY CTR ARMY 4 OH COLUMBUS WEAPONS IND RES PLANT NAVY 3 OH EVANDALE PLANT NO. 36 AF 3 OH LIMA ARMY TANK...BLANK I I I I i I I I D-19 SENSITIVE FOR OFFICIAL USE ONLY 29I 331 J11 31 Alabam .._ _ . _ _ ............. _ . BAY MNETI ALLENTOW DE FUNII X0 LAN AT NO

Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma.

PubMed

Crommentuijn, Matheus H W; Maguire, Casey A; Niers, Johanna M; Vandertop, W Peter; Badr, Christian E; Würdinger, Thomas; Tannous, Bakhos A

2016-04-01

Glioblastoma (GBM) is the most common malignant brain tumor in adults. We designed an adeno-associated virus (AAV) vector for intracranial delivery of secreted, soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) to GBM tumors in mice and combined it with the TRAIL-sensitizing cardiac glycoside, lanatoside C (lan C). We applied this combined therapy to two different GBM models using human U87 glioma cells and primary patient-derived GBM neural spheres in culture and in orthotopic GBM xenograft models in mice. In U87 cells, conditioned medium from AAV2-sTRAIL expressing cells combined with lan C induced 80% cell death. Similarly, lan C sensitized primary GBM spheres to sTRAIL causing over 90% cell death. In mice bearing intracranial U87 tumors treated with AAVrh.8-sTRAIL, administration of lan C caused a decrease in tumor-associated Fluc signal, while tumor size increased within days of stopping the treatment. Another round of lan C treatment re-sensitized GBM tumor to sTRAIL-induced cell death. AAVrh.8-sTRAIL treatment alone and combined with lanatoside C resulted in a significant decrease in tumor growth and longer survival of mice bearing orthotopic invasive GBM brain tumors. In summary, AAV-sTRAIL combined with lanatoside C induced cell death in U87 glioma cells and patient-derived GBM neural spheres in culture and in vivo leading to an increased in overall mice survival. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Morphosyntax can modulate the N400 component: Event related potentials to gender-marked post-nominal adjectives

PubMed Central

Guajardo, Lourdes F.; Wicha, Nicole Y. Y.

2014-01-01

Event-related potential studies of grammatical gender agreement often report a left anterior negativity (LAN) when agreement violations occur. Some studies have shown that during sentence comprehension gender violations can also interact with semantic processing to modulate a negativity associated with processing meaning – the N400. Given that the LAN and N400 overlap in time, they are identified by their scalp distributions and purported functional roles. Critically, grammatical gender violations also elicit a right posterior positivity that can overlap temporally with and potentially affect the scalp distribution of the LAN/N400. We measured the effect of grammatical gender violations in the LAN/N400 window and late positive component (LPC) during comprehension of Spanish sentences. A post-nominal adjective could either make sense or not, and either agree or disagree in gender with the preceding noun. We observed a negativity to gender agreement violations in the LAN/N400 window (300–500 ms post stimulus onset) that was smaller than the semantic-congruity N400, but overlapped with it in time and distribution. The early portion of the LPC to gender violations was modulated by sentence constraint, occurring as early as 450ms in highly constraining sentences. A subadditive interaction occurred at the later portion of the LPC with equivalent effects for single and double violations (gender and semantics), reflecting a general stage of reprocessing. Overall, our data support models of language comprehension whereby both semantic and morphosyntactic information can affect processing at similar time points. PMID:24462934

Morphosyntax can modulate the N400 component: event related potentials to gender-marked post-nominal adjectives.

PubMed

Guajardo, Lourdes F; Wicha, Nicole Y Y

2014-05-01

Event-related potential studies of grammatical gender agreement often report a left anterior negativity (LAN) when agreement violations occur. Some studies have shown that during sentence comprehension gender violations can also interact with semantic processing to modulate a negativity associated with processing meaning - the N400. Given that the LAN and N400 overlap in time, they are identified by their scalp distributions and purported functional roles. Critically, grammatical gender violations also elicit a right posterior positivity that can overlap temporally and potentially affect the scalp distribution of the LAN/N400. We measured the effect of grammatical gender violations in the LAN/N400 window and late positive component (LPC) during comprehension of Spanish sentences. A post-nominal adjective could either make sense or not, and either agree or disagree in gender with the preceding noun. We observed a negativity to gender agreement violations in the LAN/N400 window (300-500ms post stimulus onset) that was smaller than the semantic-congruity N400, but overlapped with it in time and distribution. The early portion of the LPC to gender violations was modulated by sentence constraint, occurring as early as 450ms in highly constraining sentences. A subadditive interaction occurred at the later portion of the LPC with equivalent effects for single and double violations (gender and semantics), reflecting a general stage of reprocessing. Overall, our data support models of language comprehension whereby both semantic and morphosyntactic information can affect processing at similar time points. Copyright © 2014 Elsevier Inc. All rights reserved.

Local Area Network: Community Involvement, Social Capital, and Glocalization at NetU

ERIC Educational Resources Information Center

Trevett-Smith, Matthew D.

2010-01-01

Ethnographic and interview data from a long-term study of "NetU," a wired community and college, are used to investigate the effects of computer-mediated communication on social relationships. During the course of this research "LAN" residents of NetU are compared with a similar group of non-LAN residents who lived in the same neighborhood, but…

Networking CD-ROMs: The Decision Maker's Guide to Local Area Network Solutions.

ERIC Educational Resources Information Center

Elshami, Ahmed M.

In an era when patrons want access to CD-ROM resources but few libraries can afford to buy multiple copies, CD-ROM local area networks (LANs) are emerging as a cost-effective way to provide shared access. To help librarians make informed decisions, this manual offers information on: (1) the basics of LANs, a "local area network primer";…

NHEXAS PHASE I ARIZONA STUDY--STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF THE LAN AND RELATED MICROCOMPUTER ENVIRONMENT (UA-D-1.1)

EPA Science Inventory

The purpose of this SOP is to describe procedures for using and maintaining the local area network (LAN) and related microcomputer equipment at the HRP Site of the Arizona Prevention Center. These methods were used for all data operations and maintenance routines during the Ariz...

U.S.-MEXICO BORDER PROGRAM ARIZONA BORDER STUDY--STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF THE LAN AND RELATED MICROCOMPUTER ENVIRONMENT (UA-D-1.1)

EPA Science Inventory

The purpose of this SOP is to describe procedures for using and maintaining the local area network (LAN) and related microcomputer equipment at the Health Related Professions site at the University of Arizona. These methods were used for all data operations and maintenance routi...

Local Area Network (LAN) Compatibility Issues

DTIC Science & Technology

1991-09-01

September, 1991 Thesis Advisor: Dr. Norman Schneidewind Approved for public release; distribution is unlimited 92 303s246 Unclassified SECURITY ...CLASSIFICATION OF THIS PAGE REPORT DOCUMENTATION PAGE Ia. REPORT SECURITY CLASSIFICATION 1 b. RESTRICTIVE MARKINGS unclassified 2a. SECURITY CLASSIFICATION...Work UiNt ACCeLUOn Number 11. TITLE (Include Security Classification) LOCAL AREA NETWORK (LAN) COMPATIBILITY ISSUES 12. PERSONAL AUTHOR(S) Rita V

Multicast routing for wavelength-routed WDM networks with dynamic membership

NASA Astrophysics Data System (ADS)

Huang, Nen-Fu; Liu, Te-Lung; Wang, Yao-Tzung; Li, Bo

2000-09-01

Future broadband networks must support integrated services and offer flexible bandwidth usage. In our previous work, we explore the optical link control layer on the top of optical layer that enables the possibility of bandwidth on-demand service directly over wavelength division multiplexed (WDM) networks. Today, more and more applications and services such as video-conferencing software and Virtual LAN service require multicast support over the underlying networks. Currently, it is difficult to provide wavelength multicast over the optical switches without optical/electronic conversions although the conversion takes extra cost. In this paper, based on the proposed wavelength router architecture (equipped with ATM switches to offer O/E and E/O conversions when necessary), a dynamic multicast routing algorithm is proposed to furnish multicast services over WDM networks. The goal is to joint a new group member into the multicast tree so that the cost, including the link cost and the optical/electronic conversion cost, is kept as less as possible. The effectiveness of the proposed wavelength router architecture as well as the dynamic multicast algorithm is evaluated by simulation.

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma.

PubMed

Azzarito, Tommaso; Venturi, Giulietta; Cesolini, Albino; Fais, Stefano

2015-01-28

Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sensitization of human melanoma cells to Paclitaxel (PTX). Our results show that PTX and the PPI Lansoprazole (LAN) combination was extremely efficient against metastatic melanoma cells, as compared to the single treatments, both in vitro and in vivo. We also showed that acidity plays an important role on the anti-tumor activity of these drugs, being detrimental for PTX activity, while crucial for the synergistic effect of PTX following pretreatment with LAN, due to its nature of pro-drug needing protonation for a full activation. We obtained straightforward results in a human melanoma xenograft model combining well tolerated LAN doses with suboptimal and poorly toxic doses of PTX. With this study we provide a clear evidence that the PPI LAN may be included in new combined therapy of human melanoma together with low doses of PTX. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

A mixed-modem approach to data isolation on a broadband local area network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crutcher, R.I.; Ewing, P.D.

1988-01-01

Data isolation is required to broadband networks to prevent unauthorized access to the sensitive data of other users. Isolation can be obtained by using equipment from more than one manufacturer to introduce incompatibility between nonassociated users. This paper develops the basis for isolation and postulates that four layers of isolation will exist when the proper equipment is chosen. An experimental broadband local area network (LAN) was constructed to verify isolation. This independent network allowed variations in operating conditions without causing interference in normal broadband operations. The measured results indicate that a broadband LAN can transmit data of varying sensitivity levelsmore » without compromising data security. When combined with certain administrative restrictions, the mixed-modem technique provides a cost-effective method of sharing a broadband network while maintaining isolation of data having different sensitivities. 5 refs., 2 figs.« less

A mixed-modem solution for sensitive data segregation on a broadband network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crutcher, R.I.; Ewing, P.D.

1988-01-01

Data isolation is required in broadband networks to prevent unauthorized access to the sensitive data of other users. Isolation can be obtained by using equipment from different manufacturers to introduce incompatibility between nonassociated users. This paper develops the basis for isolation and postulates that four layers of ioslation will exist when the proper equipment is chosen. An experimental broadband local area network (LAN) was constructed to verify isolation. This independent test system allowed variations to network operating conditions without causing interference to normal broadband operations. The measured results indicate that a broadband LAN can transmit data of varying sensitivity levelsmore » without compromising data security. When combined with the proper administrative restrictions, the mixed-modem technique provides a cost-effective method of sharing a broadband network while maintaining isolation of data having different sensitivities. 6 refs., 3 figs.« less

LANL Institutional Decision Support By Process Modeling and Analysis Group (AET-2)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Booth, Steven Richard

2016-04-04

AET-2 has expertise in process modeling, economics, business case analysis, risk assessment, Lean/Six Sigma tools, and decision analysis to provide timely decision support to LANS leading to continuous improvement. This capability is critical during the current tight budgetary environment as LANS pushes to identify potential areas of cost savings and efficiencies. An important arena is business systems and operations, where processes can impact most or all laboratory employees. Lab-wide efforts are needed to identify and eliminate inefficiencies to accomplish Director McMillan’s charge of “doing more with less.” LANS faces many critical and potentially expensive choices that require sound decision supportmore » to ensure success. AET-2 is available to provide this analysis support to expedite the decisions at hand.« less

Computer program for calculating aerodynamic characteristics of upper-surface-blowing and over-wing-blowing configurations

NASA Technical Reports Server (NTRS)

Lan, C. E.; Fillman, G. L.; Fox, C. H., Jr.

1977-01-01

The program is based on the inviscid wing-jet interaction theory of Lan and Campbell, and the jet entrainment theory of Lan. In the interaction theory, the flow perturbations are computed both inside and outside the jet, separately, and then matched on the jet surface to satisfy the jet boundary conditions. The jet Mach number is allowed to be different from the free stream value (Mach number nonuniformity). These jet boundary conditions require that the static pressure be continuous across the jet surface which must always remain as a stream surface. These conditions, as well as the wing-surface tangency condition, are satisified only in the linearized sense. The detailed formulation of these boundary conditions is based on the quasi-vortex-lattice method of Lan.

"Reliability Of Fiber Optic Lans"

NASA Astrophysics Data System (ADS)

Code n, Michael; Scholl, Frederick; Hatfield, W. Bryan

1987-02-01

Fiber optic Local Area Network Systems are being used to interconnect increasing numbers of nodes. These nodes may include office computer peripherals and terminals, PBX switches, process control equipment and sensors, automated machine tools and robots, and military telemetry and communications equipment. The extensive shared base of capital resources in each system requires that the fiber optic LAN meet stringent reliability and maintainability requirements. These requirements are met by proper system design and by suitable manufacturing and quality procedures at all levels of a vertically integrated manufacturing operation. We will describe the reliability and maintainability of Codenoll's passive star based systems. These include LAN systems compatible with Ethernet (IEEE 802.3) and MAP (IEEE 802.4), and software compatible with IBM Token Ring (IEEE 802.5). No single point of failure exists in this system architecture.

Design and Implementation of Secure Area Expansion Scheme for Public Wireless LAN Services

NASA Astrophysics Data System (ADS)

Watanabe, Ryu; Tanaka, Toshiaki

Recently, wireless LAN (WLAN) technology has become a major wireless communication method. The communication bandwidth is increasing and speeds have attained rates exceeding 100 Mbps. Therefore, WLAN technology is regarded as one of the promising communication methods for future networks. In addition, public WLAN connection services can be used in many locations. However, the number of the access points (AP) is insufficient for seamless communication and it cannot be said that users can use the service ubiquitously. An ad-hoc network style connection can be used to expand the coverage area of a public WLAN service. By relaying the user messages among the user nodes, a node can obtain an Internet connection via an AP, even though the node is located outside the AP's direct wireless connection area. Such a coverage area extending technology has many advantages thanks to the feature that no additional infrastructure is required. Therefore, there is a strong demand for this technology as it allows the cost-effective construction of future networks. When a secure ad-hoc routing protocol is used for message exchange in the WLAN service, the message routes are protected from malicious behavior such as route forging and can be maintained appropriately. To do this, however, a new node that wants to join the WLAN service has to obtain information such as the public key certificate and IP address in order to start secure ad-hoc routing. In other words, an initial setup is required for every network node to join the WLAN service properly. Ordinarily, such information should be assigned from the AP. However, new nodes cannot always contact an AP directly. Therefore, there are problems about information delivery in the initial setup of a network node. These problems originate in the multi hop connection based on the ad-hoc routing protocols. In order to realize an expanded area WLAN service, in this paper, the authors propose a secure public key certificate and address provision scheme during the initial setup phase on mobile nodes for the service. The proposed scheme also considers the protection of user privacy. Accordingly, none of the user nodes has to reveal their unique and persistent information to other nodes. Instead of using such information, temporary values are sent by an AP to mobile nodes and used for secure ad-hoc routing operations. Therefore, our proposed scheme prevents tracking by malicious parties by avoiding the use of unique information. Moreover, a test bed was also implemented based on the proposal and an evaluation was carried out in order to confirm performance. In addition, the authors describe a countermeasure against denial of service (DoS) attacks based on the approach to privacy protection described in our proposal.

On Information Retrieval (IR) Systems: Revisiting Their Development, Evaluation Methodologies, and Assumptions (SIGs LAN, ED).

ERIC Educational Resources Information Center

Stirling, Keith

2000-01-01

Describes a session on information retrieval systems that planned to discuss relevance measures with Web-based information retrieval; retrieval system performance and evaluation; probabilistic independence of index terms; vector-based models; metalanguages and digital objects; how users assess the reliability, timeliness and bias of information;…

Status and Trends in Networking at LHC Tier1 Facilities

NASA Astrophysics Data System (ADS)

Bobyshev, A.; DeMar, P.; Grigaliunas, V.; Bigrow, J.; Hoeft, B.; Reymund, A.

2012-12-01

The LHC is entering its fourth year of production operation. Most Tier1 facilities have been in operation for almost a decade, when development and ramp-up efforts are included. LHC's distributed computing model is based on the availability of high capacity, high performance network facilities for both the WAN and LAN data movement, particularly within the Tier1 centers. As a result, the Tier1 centers tend to be on the leading edge of data center networking technology. In this paper, we analyze past and current developments in Tier1 LAN networking, as well as extrapolating where we anticipate networking technology is heading. Our analysis will include examination into the following areas: • Evolution of Tier1 centers to their current state • Evolving data center networking models and how they apply to Tier1 centers • Impact of emerging network technologies (e.g. 10GE-connected hosts, 40GE/100GE links, IPv6) on Tier1 centers • Trends in WAN data movement and emergence of software-defined WAN network capabilities • Network virtualization

Wireless infrared communications for space and terrestrial applications

NASA Technical Reports Server (NTRS)

Crimmins, James W.

1993-01-01

Voice and data communications via wireless (and fiberless) optical means has been commonplace for many years. However, continuous advances in optoelectronics and microelectronics have resulted in significant advances in wireless optical communications over the last decade. Wilton has specialized in diffuse infrared voice and data communications since 1979. In 1986, NASA Johnson Space Center invited Wilton to apply its wireless telecommunications and factory floor technology to astronaut voice communications aboard the shuttle. In September, 1988 a special infrared voice communications system flew aboard a 'Discovery' Shuttle mission as a flight experiment. Since then the technology has been further developed, resulting in a general purpose of 2Mbs wireless voice/data LAN which has been tested for a variety of applications including use aboard Spacelab. Funds for Wilton's wireless IR development were provided in part by NASA's Technology Utilization Office and by the NASA Small Business Innovative Research Program. As a consequence, Wilton's commercial product capability has been significantly enhanced to include diffuse infrared wireless LAN's as well as wireless infrared telecommunication systems for voice and data.

Compact and high-sensitivity 100-Gb/s (4 × 25 Gb/s) APD-ROSA with a LAN-WDM PLC demultiplexer.

PubMed

Yoshimatsu, Toshihide; Nada, Masahiro; Oguma, Manabu; Yokoyama, Haruki; Ohno, Tetsuichiro; Doi, Yoshiyuki; Ogawa, Ikuo; Takahashi, Hiroshi; Yoshida, Eiji

2012-12-10

We demonstrate an integrated 100 GbE receiver optical sub-assembly (ROSA) that incorporates a monolithic four-channel avalanche photodiode (APD) array and a planer lightwave circuit (PLC) based LAN-WDM demultiplexer. A record minimum receiver sensitivity of -20 dBm and 50-km error-free SMF transmission without an optical amplifier have been achieved.

Rethinking Mobile Telephony with the IMP

DTIC Science & Technology

2011-01-01

in the telephony industry, and portions of it such as SS7 or SCTP signaling are packet-switched, deployed mobile telephony access infrastructure is...deployment of wireless LAN technology raises the question of how a mobile telephony system might instead be architected to use wireless LAN access ...and wireless access points has made universal Internet access increasingly convenient. There are clearly barriers to this vision of accessing a

Would the "Real" Girl Gamer Please Stand Up? Gender, LAN Cafes and the Reformulation of the "Girl" Gamer

ERIC Educational Resources Information Center

Beavis, Catherine; Charles, Claire

2007-01-01

In this paper we consider the significance of cyber "LAN" cafes as sites where on and off-line practices meet in way that complicates binary notions of the gendered gamer. Existing research into computer games culture suggests a male dominated environment and points to girls' lower levels of competence and participation in games. Building on…

A multicenter, observational study of lanreotide depot/autogel (LAN) in patients with acromegaly in the United States: 2-year experience from the SODA registry.

PubMed

Salvatori, Roberto; Gordon, Murray B; Woodmansee, Whitney W; Ioachimescu, Adriana G; Carver, Don W; Mirakhur, Beloo; Cox, David; Molitch, Mark E

2017-12-01

This analysis evaluates the 2-year effectiveness and safety of lanreotide depot/autogel (LAN), as well as treatment convenience and acromegaly symptom relief, from the Somatuline ® Depot for Acromegaly (SODA) registry, a post-marketing, open-label, observational, multicenter, United States registry study. Patients with acromegaly treated with LAN were eligible for enrollment. Demographics, LAN dose, extended dosing interval (EDI) (interval of injections ≥42 days), insulin-like growth factor 1 (IGF-1), growth hormone (GH), glycated hemoglobin, adverse events (AEs), injection convenience, and symptom data were collected. As of September 29, 2014, 241 patients were enrolled in SODA. IGF-1 levels below age- and gender-adjusted upper normal limit (ULN) were achieved in 71.2% at month (M) 12 and 74.4% at M24; GH ≤2.5 µg/L in 83.3% at M12 and 80.0% at M24; GH <1.0 µg/L in 61.7% at M12 and 61.4% at M24. Both IGF-1 < ULN and GH ≤2.5 µg/L were achieved in 65.0% at M12 and 54.8% at M24; both IGF-1 < ULN and GH < 1.0 µg/L were achieved in 51.7 and 42.9% at M12 and M24, respectively. EDI regimen was 5.0% at baseline and 12.0% at M24. At M24, acromegaly symptoms appeared stable or improved. The most common AE was arthralgia (25.7%). Among 106 serious AEs reported by 42 patients, 10 were deemed related to therapy in 9 patients. At M24, 73.1% of patients rated LAN as convenient. SODA indicates 2-year biochemical control with majority of patients achieving both IGF-1 < ULN and GH ≤2.5 µg/L. LAN was generally well tolerated with no new or unexpected safety signals reported during the observation period. clinicaltrials.gov Clinical Trial Identifier: NCT00686348.

The effect of dim light at night on cerebral hemodynamic oscillations during sleep: A near-infrared spectroscopy study.

PubMed

Kim, Tae-Joon; Lee, Byeong Uk; Sunwoo, Jun-Sang; Byun, Jung-Ick; Moon, Jangsup; Lee, Soon-Tae; Jung, Keun-Hwa; Chu, Kon; Kim, Manho; Lim, Jong-Min; Lee, Eunil; Lee, Sang Kun; Jung, Ki-Young

2017-01-01

Recent studies have reported that dim light at night (dLAN) is associated with risks of cardiovascular complications, such as hypertension and carotid atherosclerosis; however, little is known about the underlying mechanism. Here, we evaluated the effect of dLAN on the cerebrovascular system by analyzing cerebral hemodynamic oscillations using near-infrared spectroscopy (NIRS). Fourteen healthy male subjects underwent polysomnography coupled with cerebral NIRS. The data collected during sleep with dim light (10 lux) were compared with those collected during sleep under the control dark conditions for the sleep structure, cerebral hemodynamic oscillations, heart rate variability (HRV), and their electroencephalographic (EEG) power spectrum. Power spectral analysis was applied to oxy-hemoglobin concentrations calculated from the NIRS signal. Spectral densities over endothelial very-low-frequency oscillations (VLFOs) (0.003-0.02 Hz), neurogenic VLFOs (0.02-0.04 Hz), myogenic low-frequency oscillations (LFOs) (0.04-0.15 Hz), and total LFOs (0.003-0.15 Hz) were obtained for each sleep stage. The polysomnographic data revealed an increase in the N2 stage under the dLAN conditions. The spectral analysis of cerebral hemodynamics showed that the total LFOs increased significantly during slow-wave sleep (SWS) and decreased during rapid eye movement (REM) sleep. Specifically, endothelial (median of normalized value, 0.46 vs. 0.72, p = 0.019) and neurogenic (median, 0.58 vs. 0.84, p = 0.019) VLFOs were enhanced during SWS, whereas endothelial VLFOs (median, 1.93 vs. 1.47, p = 0.030) were attenuated during REM sleep. HRV analysis exhibited altered spectral densities during SWS induced by dLAN, including an increase in very-low-frequency and decreases in low-frequency and high-frequency ranges. In the EEG power spectral analysis, no significant difference was detected between the control and dLAN conditions. In conclusion, dLAN can disturb cerebral hemodynamics via the endothelial and autonomic systems without cortical involvement, predominantly during SWS, which might represent an underlying mechanism of the increased cerebrovascular risk associated with light exposure during sleep.

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.

PubMed

Dong, Hongli; Claffey, Kevin P; Brocke, Stefan; Epstein, Paul M

2013-01-01

Considerable epidemiological evidence demonstrates a positive association between artificial light at night (LAN) levels and incidence rates of breast cancer, suggesting that exposure to LAN is a risk factor for breast cancer. There is a 30-50% higher risk of breast cancer in the highest LAN exposed countries compared to the lowest LAN countries, and studies showing higher incidence of breast cancer among shift workers exposed to more LAN have led the International Agency for Research on Cancer to classify shift work as a probable human carcinogen. Nevertheless, the means by which light can affect breast cancer is still unknown. In this study we examined established human breast cancer cell lines and patients' primary breast cancer tissues for expression of genetic components of phosphodiesterase 6 (PDE6), a cGMP-specific PDE involved in transduction of the light signal, and previously thought to be selectively expressed in photoreceptors. By microarray analysis we find highly significant expression of mRNA for the PDE6B, PDE6C, and PDE6D genes in both the cell lines and patients' tissues, minimal expression of PDE6A and PDE6G and no expression of PDE6H. Using antibody specific for PDE6β, we find expression of PDE6B protein in a wide range of patients' tissues by immunohistochemistry, and in MCF-7 breast cancer cells by immunofluorescence and Western blot analysis. Considerable expression of key circadian genes, PERIOD 2, CLOCK, TIMELESS, CRYPTOCHROME 1, and CRYPTOCHROME 2 was also seen in all breast cancer cell lines and all patients' breast cancer tissues. These studies indicate that genes for PDE6 and control of circadian rhythm are expressed in human breast cancer cells and tissues and may play a role in transducing the effects of light on breast cancer.

GLOBECOM '88 - IEEE Global Telecommunications Conference and Exhibition, Hollywood, FL, Nov. 28-Dec. 1, 1988, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Various papers on communications for the information age are presented. Among the general topics considered are: telematic services and terminals, satellite communications, telecommunications mangaement network, control of integrated broadband networks, advances in digital radio systems, the intelligent network, broadband networks and services deployment, future switch architectures, performance analysis of computer networks, advances in spread spectrum, optical high-speed LANs, and broadband switching and networks. Also addressed are: multiple access protocols, video coding techniques, modulation and coding, photonic switching, SONET terminals and applications, standards for video coding, digital switching, progress in MANs, mobile and portable radio, software design for improved maintainability, multipath propagation and advanced countermeasure, data communication, network control and management, fiber in the loop, network algorithm and protocols, and advances in computer communications.

Installation of secure, always available wireless LAN systems as a component of the hospital communication infrastructure.

PubMed

Hanada, Eisuke; Kudou, Takato; Tsumoto, Shusaku

2013-06-01

Wireless technologies as part of the data communication infrastructure of modern hospitals are being rapidly introduced. Even though there are concerns about problems associated with wireless communication security, the demand is remarkably large. In addition, insuring that the network is always available is important. Herein, we discuss security countermeasures and points to insure availability that must be taken to insure safe hospital/business use of wireless LAN systems, referring to the procedures introduced at Shimane University Hospital. Security countermeasures differ according to their purpose, such as for preventing illegal use or insuring availability, both of which are discussed. It is our hope that this information will assist others in their efforts to insure safe implementation of wireless LAN systems, especially in hospitals where they have the potential to greatly improve information sharing and patient safety.

Stormwater Pollution Prevention Plan for the TA-60-02 Salvage Warehouse, Los Alamos National Laboratory, Revision 3, January 2018

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgin, Jillian Elizabeth

This Storm Water Pollution Prevention Plan (SWPPP) was developed in accordance with the provisions of the Clean Water Act (33 U.S.C. §§1251 et seq., as amended), and the Multi-Sector General Permit for Storm Water Discharges Associated with Industrial Activity (U.S. EPA, June 2015) issued by the U.S. Environmental Protection Agency (EPA) for the National Pollutant Discharge Elimination System (NPDES) and using the industry specific permit requirements for Sector P-Land Transportation and Warehousing as a guide. The applicable stormwater discharge permit is EPA General Permit Registration Number NMR053915 (Los Alamos National Security (LANS) (U.S. EPA, June 2015). Contents of the Junemore » 4, 2015 Multi-sector General Permit can be viewed at: https://www.epa.gov/sites/production/files/2015- 10/documents/msgp2015_finalpermit.pdf This SWPPP applies to discharges of stormwater from the operational areas of the TA-60-02 Salvage and Warehouse facility at Los Alamos National Laboratory. Los Alamos National Laboratory (also referred to as LANL or the “Laboratory”) is owned by the Department of Energy (DOE), and is operated by Los Alamos National Security, LLC (LANS). Throughout this document, the term “facility” refers to the TA-60-02 Salvage/ Warehouse and associated areas. The current permit expires at midnight on June 4, 2020. A copy of the facility NOI and LANS Delegation of Authority Letter are located in Appendix C of this SWPPP.« less

[Study on network architecture of a tele-medical information sharing platform].

PubMed

Pan, Lin; Yu, Lun; Chen, Jin-xiong

2006-07-01

In the article,a plan of network construction which satisfies the demand of applications for a telemedical information sharing platform is proposed. We choice network access plans in view of user actual situation, through the analysis of the service demand and many kinds of network access technologies. Hospital servers that locate in LAN link sharing platform with node servers, should separate from the broadband network of sharing platform in order to ensure the security of the internal hospital network and the administration management. We use the VPN technology to realize the safe transmission of information in the platform network. Preliminary experiments have proved the plan is practicable.

The Effectiveness of a Popular Science Promotion Program on Nanotechnology for Elementary School Students in I-Lan City

ERIC Educational Resources Information Center

Lin, Show-Yu; Wu, Ming-Ta; Cho, Ya-I; Chen, Hui-Huang

2015-01-01

Background: Nanotechnology education has become an urgent priority to nurture skilled human resources for the rapidly developing nanotechnology-related industries. The promotion of popular science education focusing on nanotechnology is an ideal approach to bridge the gaps in formal curricula, and to stimulate curiosity about and interest in…

A pilot study for the integration of cytometry reports in digital cytology telemedicine applications.

PubMed

Giansanti, Daniele; Cerroni, Fabio; Amodeo, Rachele; Filoni, Marco; Giovagnoli, Maria Rosaria

2010-01-01

Up to date, tele-pathology in the three different forms of application, "dynamic", "static" and "virtual microscopy" has been mainly based on tele-hystology remote consulting. Today the diffusion of specialized WAN connections is guiding the research of new applications of tele-pathology. A specific analysis has been conducted, focused on digital cytology, in the biomedical laboratory of Sant'Andrea Hospital to investigate the technologies potentially useful to integrate in the LAN/WAN for telemedicine applications. Among the possible tools useful to be integrated in the LAN/WAN for telemedicine applications, the cytometry equipment available in the technical unity of cytometry has been considered important. The study finally provides a proposal for a tele-consulting architecture for the integration of cytometry reports both in the hospital LAN and the WAN for possible cooperative diagnosis and second opinion support.

Does Current Scientific Evidence Support a Link Between Light at Night and Breast Cancer Among Female Night-Shift Nurses?

PubMed Central

Dickerman, Barbra; Liu, Jianghong

2014-01-01

Breast cancer is increasingly prevalent in industrialized regions of the world, and exposure to light at night (LAN) has been proposed as a potential risk factor. Epidemiological observations have documented an increased breast cancer risk among female night-shift workers, and strong experimental evidence for this relationship has also been found in rodent models. Indirect support for the LAN hypothesis comes from studies involving blind women, sleep duration, bedroom light levels, and community nighttime light levels. This article reviews the literature, discusses possible mechanisms of action, and provides recommendations for occupational health nursing research, practice, and education. Research is needed to further explore the relationship between exposure to LAN and breast cancer risk and elucidate the mechanisms underlying this relationship before interventions can be designed for prevention and mitigation of breast cancer. PMID:22658734

Ensuring the security and availability of a hospital wireless LAN system.

PubMed

Hanada, Eisuke; Kudou, Takato; Tsumoto, Shusaku

2013-01-01

Wireless technologies as part of the data communication infrastructure of modern hospitals are being rapidly introduced. Even though there are concerns about problems associated with wireless communication security, the demand is remarkably large. Herein we discuss security countermeasures that must be taken and issues concerning availability that must be considered to ensure safe hospital/business use of wireless LAN systems, referring to the procedures introduced at a university hospital. Security countermeasures differ according to their purpose, such as preventing illegal use or ensuring availability, both of which are discussed. The main focus of the availability discussion is on signal reach, electromagnetic noise elimination, and maintaining power supply to the network apparatus. It is our hope that this information will assist others in their efforts to ensure safe implementation of wireless LAN systems, especially in hospitals where they have the potential to greatly improve information sharing and patient safety.

Development and Implementation of the X.25 Protocol for the Universal Network Interface Device (UNID) II. Volume 1.

DTIC Science & Technology

1985-12-01

development of an improved Universal Network Interface Device (UNID II). The UNID II’s architecture was based on a preliminary design project at...interface device, performing all functions required ,: the multi-ring LAN. The device depicted by RADC’s studies would connect a highly variable group of host...used the ISO Open Systems Ilterconnection (OSI) seven layer model as the basic structure for data flow and program development . In 1982 Cuomo

Sensitivity Studies of 3D Reservoir Simulation at the I-Lan Geothermal Area in Taiwan Using TOUGH2

NASA Astrophysics Data System (ADS)

Kuo, C. W.; Song, S. R.

2014-12-01

A large scale geothermal project conducted by National Science Council is initiated recently in I-Lan south area, northeastern Taiwan. The goal of this national project is to generate at least 5 MW electricity from geothermal energy. To achieve this goal, an integrated team which consists of various specialties are held together to investigate I-Lan area comprehensively. For example, I-Lan geological data, petrophysical analysis, seismicity, temperature distribution, hydrology, geochemistry, heat source study etc. were performed to build a large scale 3D conceptual model of the geothermal potential sites. In addition, not only a well of 3000m deep but also several shallow wells are currently drilling to give us accurate information about the deep underground. According to the current conceptual model, the target area is bounded by two main faults, Jiaosi and Choshui faults. The geothermal gradient measured at one drilling well (1200m) is about 49.1˚C/km. The geothermal reservoir is expected to occur at a fractured geological formation, Siling sandstone layer. The preliminary results of this area from all the investigations are used as input parameters to create a realistic numerical reservoir model. This work is using numerical simulator TOUGH2/EOS1 to study the geothermal energy potential in I-Lan area. Once we can successfully predict the geothermal energy potential in this area and generate 5 MW electricity, we can apply the similar methodology to the other potential sites in Taiwan, and therefore increase the percentage of renewable energy in the generation of electricity. A large scale of three-dimensional subsurface geological model is built mainly based on the seismic exploration of the subsurface structure and well log data. The dimensions of the reservoir model in x, y, and z coordinates are 20x10x5 km, respectively. Once the conceptual model and the well locations are set up appropriately based on the field data, sensitivity studies on production and injection rates, heat source, fractures, and all the relevant parameters are performed to evaluate their effects on temperature distribution of reservoir for 30 years. Through these sensitivity studies, we can design the better geothermal system in I-Lan area and reduce the risk of exploitation.

[Meanings and conceptualizations of nursing: the point of view of students from the nursing degree program at the Universidad Nacional de Lanús, 2008-2010].

PubMed

Arakaki, Jorge

2013-08-01

This work looks into the meanings of nursing from the point of view of the students in an undergraduate nursing degree program. The research took place at the Universidad Nacional de Lanús using semistructured interviews - eleven individual and seven group interviews - carried out between 2008 and 2010. A content analysis was then undertaken and the most relevant meanings in relation to four themes were selected: reasons for studying nursing, what nursing is, nursing as a profession, and working in nursing. Multiple and diverse ways of defining nursing were uncovered. Utilizing some conceptual developments from the sociology of the professions, the meanings were organized into four conceptualizations that represent ways of understanding nursing: as a vocation, as a profession, with a utilitarian perspective and with a community perspective. The conclusions reached indicate the need to broaden the debate regarding the types of nurses that are being trained.

Local area networks in an imaging environment.

PubMed

Noz, M E; Maguire, G Q; Erdman, W A

1986-01-01

There is great interest at present in incorporating image-management systems popularly referred to as picture archiving and communication systems (PACS) into imaging departments. This paper will describe various aspects of local area networks (LANs) for medical images and will give a definition of terms and classification of devices by describing a possible system which links various digital image sources through a high-speed data link and a common image format, allows for viewing and processing of all images produced within the complex, and eliminates the transport of films. The status of standards governing LAN and particularly PACS systems along with a proposed image exchange format will be given. Prototype systems, particularly a system for nuclear medicine images, will be presented, as well as the prospects for the immediate future in terms of installations started and commercial products available. A survey of the many questions that arise in the development of a PACS for medical images and also a survey of the presently suggested/adopted answers will be given.

Federal Emergency Management Information System (FEMIS) system administration guide, version 1.4.5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arp, J.A.; Burnett, R.A.; Carter, R.J.

The Federal Emergency Management Information Systems (FEMIS) is an emergency management planning and response tool that was developed by the Pacific Northwest National Laboratory (PNNL) under the direction of the US Army Chemical Biological Defense Command. The FEMIS System Administration Guide provides information necessary for the system administrator to maintain the FEMIS system. The FEMIS system is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are connected via a local areamore » network (LAN) to servers that provide EOC-wide services. Each EOC is interconnected to other EOCs via a Wide Area Network (WAN). Thus, FEMIS is an integrated software product that resides on client/server computer architecture. The main body of FEMIS software, referred to as the FEMIS Application Software, resides on the PC client(s) and is directly accessible to emergency management personnel. The remainder of the FEMIS software, referred to as the FEMIS Support Software, resides on the UNIX server. The Support Software provides the communication, data distribution, and notification functionality necessary to operate FEMIS in a networked, client/server environment. The UNIX server provides an Oracle relational database management system (RDBMS) services, ARC/INFO GIS (optional) capabilities, and basic file management services. PNNL developed utilities that reside on the server include the Notification Service, the Command Service that executes the evacuation model, and AutoRecovery. To operate FEMIS, the Application Software must have access to a site specific FEMIS emergency management database. Data that pertains to an individual EOC`s jurisdiction is stored on the EOC`s local server. Information that needs to be accessible to all EOCs is automatically distributed by the FEMIS database to the other EOCs at the site.« less

Local network assessment

NASA Astrophysics Data System (ADS)

Glen, D. V.

1985-04-01

Local networks, related standards activities of the Institute of Electrical and Electronics Engineers the American National Standards Institute and other elements are presented. These elements include: (1) technology choices such as topology, transmission media, and access protocols; (2) descriptions of standards for the 802 local area networks (LAN's); high speed local networks (HSLN's) and military specification local networks; and (3) intra- and internetworking using bridges and gateways with protocols Interconnection (OSI) reference model. The convergence of LAN/PBX technology is also described.

Infrared transmission of electronic information via LAN in the operating room.

PubMed

Hagihira, S; Takashina, M; Mori, T; Taenaka, N; Mashimo, T; Yoshiya, I

2000-01-01

Recent advances in technology have brought many kinds of monitoring devices into the operating room (OR). The information gathered by monitors can be channeled to the operating ward information system via a local area network (LAN). Connecting patients to monitors and monitors to the LAN, however, requires a large number of cables. This wiring is generally inconvenient and particularly troublesome if the layout of the OR is rearranged. From this point of view, wireless transmission seems ideally suited to clinical settings. Currently, two modes of wireless connectivity are available: radio-frequency (RF) waves or infrared (IR) waves. Some reports suggest that RF transmission is likely to cause electromagnetic interference (EMI) in medical devices such as cardiac pacemakers or infusion pumps. The risk of malfunctioning life-sustaining devices and the catastrophic consequences this would have on seriously ill patients rules out the use of RF. Here, we report an IR system using IR modems for LAN connectivity in the OR. In this study, we focused on the possible detrimental effects of EMI during wireless connectivity. In our trial, we found no evidence of EMI of IR modems with any of the medical devices we tested. Furthermore, IR modems showed similar performance to a wired system even in an electrically noisy environment. We conclude that IR wireless connectivity can be safely and effectively used in ORs.

Ecological Impact of LAN: San Pedro Riparian National Conservation Area

NASA Astrophysics Data System (ADS)

Craine, Eric Richard; Craine, Brian L.

2015-08-01

The San Pedro River in Southeastern Arizona is home to nearly 45% of the 900 total species of birds in the United States; millions of songbirds migrate though this unique flyway every year. As the last undammed river in the Southwest, it has been called one of the “last great places” in the US. Human activity has had striking and highly visible impacts on the San Pedro River. As a result, and to help preserve and conserve the area, much of the region has been designated the San Pedro Riparian National Conservation Area (SPRNCA). Attention has been directed to impacts of population, water depletion, and border fence barriers on the riparian environment. To date, there has been little recognition that light at night (LAN), evolving with the increased local population, could have moderating influences on the area. STEM Laboratory has pioneered techniques of coordinated airborne and ground based measurements of light at night, and has undertaken a program of characterizing LAN in this region. We conducted the first aerial baseline surveys of sky brightness in 2012. Geographic Information Systems (GIS) shapefiles allow comparison and correlation of various biological databases with the LAN data. The goal is to better understand how increased dissemination of night time lighting impacts the distributions, behavior, and life cycles of biota on this ecosystem. We discuss the baseline measurements, current data collection programs, and some of the implications for specific biological systems.

Concurrent Smalltalk on the Message-Driven Processor

DTIC Science & Technology

1991-09-01

language close to Concurrent Smalltalk and having an almost identical name is CONCURRENTSMALLTALK [39] [40] independently developed by Yasuhiko Yokote and...Laboratory Memo 1044, October 1988. [391 Yokote, Yasuhiko , and Tokoro, Mario. ’The Design and Implementation of Concur- rentSmalltalk." Proceedings...of the 1986 Object-Oriented Programming Systems, Lan- guages, and Applications Conference, September 1986. 222 Bibliography [401 Yokote, Yasuhiko , and

Impact of Exposure to Dim Light at Night on Sleep in Female and Comparison with Male Subjects.

PubMed

Cho, Chul-Hyun; Yoon, Ho-Kyoung; Kang, Seung-Gul; Kim, Leen; Lee, Eun-Il; Lee, Heon-Jeong

2018-03-19

Light pollution has become a social and health issue. We performed an experimental study to investigate impact of dim light at night (dLAN) on sleep in female subjects, with measurement of salivary melatonin. The 25 female subjects (Group A: 12; Group B: 13 subjects) underwent a nocturnal polysomnography (NPSG) session with no light (Night 1) followed by an NPSG session randomly assigned to two conditions (Group A: 5; Group B: 10 lux) during a whole night of sleep (Night 2). Salivary melatonin was measured before and after sleep on each night. For further investigation, the female and male subjects of our previous study were collected (48 subjects), and differences according to gender were compared. dLAN during sleep was significantly associated with decreased total sleep time (TST; F=4.818, p=0.039), sleep efficiency (SE; F=5.072, p=0.034), and Stage R latency (F=4.664, p=0.041) for female subjects, and decreased TST (F=14.971, p<0.001) and SE (F=7.687, p=0.008), and increased wake time after sleep onset (F=6.322, p=0.015) and Stage R (F=5.031, p=0.03), with a night-group interaction (F=4.579, p=0.038) for total sample. However, no significant melatonin changes. There was no significant gender difference of the impact of dLAN on sleep, showing the negative changes in the amount and quality of sleep and the increase in REM sleep in the both gender group under 10 lux condition. We found a negative impact of exposure to dLAN on sleep in female as well as in merged subjects. REM sleep showed a pronounced increase under 10 lux than under 5 lux in merged subjects, suggesting the possibility of subtle influences of dLAN on REM sleep.

Reproductive and Hormonal Risk Factors for Breast Cancer in Blind Women

DTIC Science & Technology

2005-06-01

evidence for possible effects of exposure to light at night (LAN) on cancer risk due to the increased use of modern electric lighting (2-8...being collected via; e) We have developed and finalized informed consent procedures for the range of media being used which have been formally...have developed the questionnaire for web use <www.bvihealthsurvey.bwh.harvard.edu>. The web-site is Section 508- and W3C-compliant as required for

UTC Time Transfer for High Frequency Trading Using IS-95 CDMA Base Station Transmissions and IEEE-1588 Precision Time Protocol

DTIC Science & Technology

2010-11-01

CDMA base stations are each synchronized by GPS receivers, they provide an indirect link to GPS system time and UTC time . The major stock...antenna synchronizes the Local Area Network (LAN) to within 10 microseconds of UTC using the IEEE-1588 Precision Time Protocol (PTP). This is an...activities. Understanding and measuring latency on the LAN is key to the success of HFTs. Without precise time synchronization below 1 millisecond

Wireless Communications

NASA Astrophysics Data System (ADS)

1991-01-01

A technology utilization project led to the commercial adaptation of a Space Shuttle Orbiter wireless infrared voice communications system. The technology was adapted to a LAN system by Wilton Industries, one of the participants. Because the system is cable-free, installation charges are saved, and it can be used where cable is impractical. Resultant products include the IRplex 6000. Transceivers can be located anywhere and can include mobile receivers. The system provides wireless LAN coverage up to 44,000 square feet. applications include stock exchange communications, trade shows, emergency communications, etc.

Validation of the European Prototype for Integrated Care at Municipal Level in Savona: Updating and Maintenance

DTIC Science & Technology

2001-10-25

within one of the programmes sponsored by the European Commission.The system mainly consists of a shared care database in which each groups of...care database in which each community facility, or group of facilities, is supported by a local area network (LAN). Each of these LANs is connected over...functions. The software is layered, so that the client application is not affected by how the servers are implemented or which database system they use

An Abstract Model of Rogue Code Insertion into Radio Frequency Wireless Networks. The Effects of Computer Viruses on the Program Management Office

DTIC Science & Technology

1994-04-01

numerous articles on wireless LANs, only one by Lathrop discusses their vulnerabilities’. Lathrop’s paper provides an overview of wireless LANs and...to detect any action which deviates from the user’s observed recorded past behavior. These profiles list the operator’s commonly used commands, typing...current system activity audit records to rules describing past behavior patterns. W&S is especially effective in detecting rogue program penetrations. It

Network interface unit design options performance analysis

NASA Technical Reports Server (NTRS)

Miller, Frank W.

1991-01-01

An analysis is presented of three design options for the Space Station Freedom (SSF) onboard Data Management System (DMS) Network Interface Unit (NIU). The NIU provides the interface from the Fiber Distributed Data Interface (FDDI) local area network (LAN) to the DMS processing elements. The FDDI LAN provides the primary means for command and control and low and medium rate telemetry data transfers on board the SSF. The results of this analysis provide the basis for the implementation of the NIU.

Mean effects of turbulence on elliptic instability in fluids.

PubMed

Fabijonas, Bruce R; Holm, Darryl D

2003-03-28

Elliptic instability in fluids is discussed in the context of the Lagrangian-averaged Navier-Stokes-alpha (LANS-alpha) turbulence model. This model preserves the Craik-Criminale (CC) family of solutions consisting of a columnar eddy and a Kelvin wave. The LANS-alpha model is shown to preserve elliptic instability. However, the model shifts the critical stability angle. This shift increases (decreases) the maximum growth rate for long (short) waves. It also introduces a band of stable CC solutions for short waves.

Optimization research of railway passenger transfer scheme based on ant colony algorithm

NASA Astrophysics Data System (ADS)

Ni, Xiang

2018-05-01

The optimization research of railway passenger transfer scheme can provide strong support for railway passenger transport system, and its essence is path search. This paper realized the calculation of passenger transfer scheme for high speed railway when giving the time and stations of departure and arrival. The specific method that used were generating a passenger transfer service network of high-speed railway, establishing optimization model and searching by Ant Colony Algorithm. Finally, making analysis on the scheme from LanZhouxi to BeiJingXi which were based on high-speed railway network of China in 2017. The results showed that the transfer network and model had relatively high practical value and operation efficiency.

Present status and future directions of the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Morin, Richard L.; Forbes, Glenn S.; Gehring, Dale G.; Salutz, James R.; Pavlicek, William

1991-07-01

This joint project began in 1988 and was motivated by the need to develop an alternative to the archival process in place at that time (magnetic tape) for magnetic resonance imaging and neurological computed tomography. In addition, this project was felt to be an important step in gaining the necessary clinical experience for the future implementation of various aspects of electronic imaging. The initial phase of the project was conceived and developed to prove the concept, test the fundamental components, and produce performance measurements for future work. The key functions of this phase centered on attachment of imaging equipment (GE Signa) and archival processes using a non-dedicated (institutionally supplied) local area network (LAN). Attachment of imaging equipment to the LAN was performed using commercially available devices (Ethernet, PS/2, Token Ring). Image data were converted to ACR/NEMA format with retention of the vendor specific header information. Performance measurements were encouraging and led to the design of following projects. The second phase has recently been concluded. The major features of this phase have been to greatly expand the network, put the network into clinical use, establish an efficient and useful viewing station, include diagnostic reports in the archive data, provide wide area network (WAN) capability via ISDN, and establish two-way real-time video between remote sites. This phase has heightened both departmental and institutional thought regarding various issues raised by electronic imaging. Much discussion regarding both present as well as future archival processes has occurred. The use of institutional LAN resources has proven to be adequate for the archival function examined thus far. Experiments to date have shown that use of dedicated resources will be necessary for retrieval activities at even a basic level. This report presents an overview of the background present status and future directions of the project.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blume-Kohout, Robin J; Scholten, Travis L.

Quantum state tomography on a d-dimensional system demands resources that grow rapidly with d. They may be reduced by using model selection to tailor the number of parameters in the model (i.e., the size of the density matrix). Most model selection methods typically rely on a test statistic and a null theory that describes its behavior when two models are equally good. Here, we consider the loglikelihood ratio. Because of the positivity constraint ρ ≥ 0, quantum state space does not generally satisfy local asymptotic normality (LAN), meaning the classical null theory for the loglikelihood ratio (the Wilks theorem) shouldmore » not be used. Thus, understanding and quantifying how positivity affects the null behavior of this test statistic is necessary for its use in model selection for state tomography. We define a new generalization of LAN, metric-projected LAN, show that quantum state space satisfies it, and derive a replacement for the Wilks theorem. In addition to enabling reliable model selection, our results shed more light on the qualitative effects of the positivity constraint on state tomography.« less

Projective limits of state spaces III. Toy-models

NASA Astrophysics Data System (ADS)

Lanéry, Suzanne; Thiemann, Thomas

2018-01-01

In this series of papers, we investigate the projective framework initiated by Kijowski (1977) and Okołów (2009, 2014, 2013) [1,2], which describes the states of a quantum theory as projective families of density matrices. A short reading guide to the series can be found in Lanéry (2016). A strategy to implement the dynamics in this formalism was presented in our first paper Lanéry and Thiemann (2017) (see also Lanéry, 2016, section 4), which we now test in two simple toy-models. The first one is a very basic linear model, meant as an illustration of the general procedure, and we will only discuss it at the classical level. In the second one, we reformulate the Schrödinger equation, treated as a classical field theory, within this projective framework, and proceed to its (non-relativistic) second quantization. We are then able to reproduce the physical content of the usual Fock quantization.

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6

PubMed Central

Fukuda, Yu; Cheong, Pak Leng; Lynch, John; Brighton, Cheryl; Frase, Sharon; Kargas, Vasileios; Rampersaud, Evadnie; Wang, Yao; Sankaran, Vijay G.; Yu, Bing; Ney, Paul A.; Weiss, Mitchell J.; Vogel, Peter; Bond, Peter J.; Ford, Robert C.; Trent, Ronald J.; Schuetz, John D.

2016-01-01

Hereditary porphyrias are caused by mutations in genes that encode haem biosynthetic enzymes with resultant buildup of cytotoxic metabolic porphyrin intermediates. A long-standing open question is why the same causal porphyria mutations exhibit widely variable penetrance and expressivity in different individuals. Here we show that severely affected porphyria patients harbour variant alleles in the ABCB6 gene, also known as Lan, which encodes an ATP-binding cassette (ABC) transporter. Plasma membrane ABCB6 exports a variety of disease-related porphyrins. Functional studies show that most of these ABCB6 variants are expressed poorly and/or have impaired function. Accordingly, homozygous disruption of the Abcb6 gene in mice exacerbates porphyria phenotypes in the Fechm1Pas mouse model, as evidenced by increased porphyrin accumulation, and marked liver injury. Collectively, these studies support ABCB6 role as a genetic modifier of porphyria and suggest that porphyrin-inducing drugs may produce excessive toxicities in individuals with the rare Lan(−) blood type. PMID:27507172

Android Video Streaming

DTIC Science & Technology

2014-05-01

natural choice. In this document, we describe several aspects of video streaming and the challenges of performing video streaming between Android-based...client application was needed. Typically something like VideoLAN Client ( VLC ) is used for this purpose in a desktop environment. However, while VLC is...a very mature application on Windows and Linux, VLC for Android is still in a beta testing phase, and versions have only been developed to work

Local-Area-Network Simulator

NASA Technical Reports Server (NTRS)

Gibson, Jim; Jordan, Joe; Grant, Terry

1990-01-01

Local Area Network Extensible Simulator (LANES) computer program provides method for simulating performance of high-speed local-area-network (LAN) technology. Developed as design and analysis software tool for networking computers on board proposed Space Station. Load, network, link, and physical layers of layered network architecture all modeled. Mathematically models according to different lower-layer protocols: Fiber Distributed Data Interface (FDDI) and Star*Bus. Written in FORTRAN 77.

Techniques for the Detection of Faulty Packet Header Modifications

DTIC Science & Technology

2014-03-12

layer approaches to check if packets are being altered by middleboxes and were primarily developed as network neutrality analysis tools. Switzerland works...local and metropolitan area networks –specific requirements part 11: Wireless LAN medium access control (MAC) and physical layer (PHY) specifications...policy or position of the Department of Defense or the U.S. Government. Understanding, measuring, and debugging IP networks , particularly across

The effectiveness of a popular science promotion program on nanotechnology for elementary school students in I-Lan City

NASA Astrophysics Data System (ADS)

Lin, Show-Yu; Wu, Ming-Ta; Cho, Ya-I.; Chen, Hui-Huang

2015-01-01

Background:Nanotechnology education has become an urgent priority to nurture skilled human resources for the rapidly developing nanotechnology-related industries. The promotion of popular science education focusing on nanotechnology is an ideal approach to bridge the gaps in formal curricula, and to stimulate curiosity about and interest in nanotechnology among schoolchildren. Purpose:The objective of this study was to evaluate the effectiveness of the Nanotechnology-based Popular Science Education Promotion and Teaching (NPSEPT) program through camp activity that was implemented in elementary schools in I-Lan City, Taiwan. Program description:To create a competitive advantage, a human resources development program was implemented as one of the nanotechnology incubation projects in Taiwan and focused on developing an appropriately-skilled professional workforce as well as promoting popular science education. Sample:The volunteer research participants were 323 sixth grade students in four elementary schools in I-Lan City, Taiwan, who were evaluated at the beginning and the end of the nanotechnology-based popular science promotion camp activity. Design and methods:A research tool called the 'NPSEPT test' was designed specifically for this study and was approved by experts who evaluated its content and face validity. The questionnaire was divided into three aspects: 'Nanophenomena in the natural world'; 'Nanomaterials and their scaling effects'; and 'Definition, characteristics, and applications of nanotechnology.' The effectiveness of learning among the students was analyzed using descriptive statistics, a paired sample t-test, analysis of variance (ANOVA) and a post hoc comparison. Results:The results of the three-part 'NPSEPT test' revealed that NPSEPT significantly advanced nanotechnology learning performance and outcomes among students in the four participating elementary schools. Of the 15 questions included in the NPSEPT test, positive change for more than 30% of students was achieved for eight questions related to nanotechnology concepts.