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Sample records for lang allan sims

  1. Spatial-temporal framework for the closure of the Junggar Ocean in central Asia: New SIMS zircon U-Pb ages of the ophiolitic mélange and collisional igneous rocks in the Zhifang area, East Junggar

    NASA Astrophysics Data System (ADS)

    Xu, Xing-Wang; Jiang, Neng; Li, Xian-Hua; Wu, Chu; Qu, Xun; Zhou, Gang; Dong, Lian-Hui

    2015-11-01

    The closure time of the Junggar Ocean is one of the hottest topics surrounding the tectonic evolution of the Central Asian Orogenic Belt (CAOB). This paper reports SIMS zircon U-Pb ages of the ophiolitic mélange and collisional igneous rocks in the Zhifang area, East Junggar. Our new results reveal the following evidence: (1) the West Hill ophiolitic mélange in the Zhifang area contains segments of the 371 Ma MORB-type layered rocks and 363 Ma oceanic islands, which were intruded by the 348 Ma syn-collisional quartz diorites; (2) the ophiolitic mélange and 348 Ma syn-collisional quartz diorites are overlain by the 342 Ma andesitic tuffs; and (3) the 342 Ma andesitic tuffs and successive 332 Ma granodiorites-gabbro were formed at late-collisional setting, whereas the 314 Ma granitic porphyry at post-collisional setting. We suggest that the Junggar Ocean in the Zhifang area was opened before 371 Ma and 363 Ma, and possibly closed before 348 Ma. By combining the published U-Pb ages of the Mayile-Tangbale-Darbute-Kalamaili-Zhifang-Daheishan (MTDKZD) ophiolite belt, Early-Carboniferous volcanic rocks unconformably overlying the MTDKZD ophiolite belt, bimodal volcanic rocks and granitoids within and adjacent to the MTDKZD ophiolite belt, it is suggested that the Junggar Ocean was possibly opened scissors-like from the Neoproterozoic-Ordovician Mayile-Tangbale ocean eastwards through the Silurian-Devonian Darbute-Karamay ocean finally to the Devonian-Early-Carboniferous Kalamaili-Zhifang ocean, and closed scissors-like from the Zhifang-Kalamaili area in the eastern segment westwards to the Darbute-Karamay area in the western segment. Tectonic collage between the Yemaquan-Xiemisitai arc and Junggar block occurred at approximately 343-348 Ma. The Junggar orogenic belt went through late-collisional stage at 343-330 Ma, post-collisional period after 330 Ma, and post-collisional extensional regime after 320 Ma with an intensive stage at around 303 Ma.

  2. The quantum Allan variance

    NASA Astrophysics Data System (ADS)

    Chabuda, Krzysztof; Leroux, Ian D.; Demkowicz-Dobrzański, Rafał

    2016-08-01

    The instability of an atomic clock is characterized by the Allan variance, a measure widely used to describe the noise of frequency standards. We provide an explicit method to find the ultimate bound on the Allan variance of an atomic clock in the most general scenario where N atoms are prepared in an arbitrarily entangled state and arbitrary measurement and feedback are allowed, including those exploiting coherences between succeeding interrogation steps. While the method is rigorous and general, it becomes numerically challenging for large N and long averaging times.

  3. Spectral Ambiguity of Allan Variance

    NASA Technical Reports Server (NTRS)

    Greenhall, C. A.

    1996-01-01

    We study the extent to which knowledge of Allan variance and other finite-difference variances determines the spectrum of a random process. The variance of first differences is known to determine the spectrum. We show that, in general, the Allan variance does not. A complete description of the ambiguity is given.

  4. Allan Cox 1926”1987

    NASA Astrophysics Data System (ADS)

    Coe, Rob; Dalrymple, Brent

    More than 1000 friends, students, and colleagues from all over the country filled Stanford Memorial Chapel (Stanford, Calif.) on February 3, 1987, to join in “A Celebration of the Life of Allan Cox.” Allan died early on the morning of January 27 while bicycling, the sport he had come to love the most. Between pieces of his favorite music by Bach and Mozart, Stanford administrators and colleagues spoke in tribute of Allan's unique qualities as friend, scientist, teacher, and dean of the School of Earth Sciences. James Rosse, Vice President and Provost of Stanford University, struck a particularly resonant chord with his personal remarks: "Allan reached out to each person he knew with the warmth and attention that can only come from deep respect and affection for others. I never heard him speak ill of others, and I do not believe he was capable of doing anything that would harm another being. He cared too much to intrude where he was not wanted, but his curiosity about people and the loving care with which he approached them broke down reserve to create remarkable friendships. His enthusiasm and good humor made him a welcome guest in the hearts of the hundreds of students and colleagues who shared the opportunity of knowing Allan Cox as a person."

  5. Edgar Allan Poe and neurology.

    PubMed

    Teive, Hélio Afonso Ghizoni; Paola, Luciano de; Munhoz, Renato Puppi

    2014-06-01

    Edgar Allan Poe was one of the most celebrated writers of all time. He published several masterpieces, some of which include references to neurological diseases. Poe suffered from recurrent depression, suggesting a bipolar disorder, as well as alcohol and drug abuse, which in fact led to his death from complications related to alcoholism. Various hypotheses were put forward, including Wernicke's encephalopathy.

  6. Allan Bloom, America, and Education.

    ERIC Educational Resources Information Center

    West, Thomas

    2000-01-01

    Refutes the claims of Allan Bloom that the source of the problem with today's universities is modern philosophy, that the writings and ideas of Hobbes and Locke planted the seeds of relativism in American culture, and that the cure is Great Books education. Suggests instead that America's founding principles are the only solution to the failure of…

  7. Allan Bloom, America, and Education.

    ERIC Educational Resources Information Center

    West, Thomas

    2000-01-01

    Refutes the claims of Allan Bloom that the source of the problem with today's universities is modern philosophy, that the writings and ideas of Hobbes and Locke planted the seeds of relativism in American culture, and that the cure is Great Books education. Suggests instead that America's founding principles are the only solution to the failure of…

  8. Allan Bloom's Quarrel with History.

    ERIC Educational Resources Information Center

    Thompson, James

    1988-01-01

    Responds to Allan Bloom's "The Closing of the American Mind." Concludes that despite cranky comments about bourgeois culture, the focus of Bloom's attack is on historicism, which undercuts his nostalgic vision of a prosperous and just America. Condemns Bloom's exclusion of Blacks, Hispanics, and women from America's cultural heritage.…

  9. Estimating the Modified Allan Variance

    NASA Technical Reports Server (NTRS)

    Greenhall, Charles

    1995-01-01

    The third-difference approach to modified Allan variance (MVAR) leads to a tractable formula for a measure of MVAR estimator confidence, the equivalent degrees of freedom (edf), in the presence of power-law phase noise. The effect of estimation stride on edf is tabulated. A simple approximation for edf is given, and its errors are tabulated. A theorem allowing conservative estimates of edf in the presence of compound noise processes is given.

  10. A Wavelet Perspective on the Allan Variance.

    PubMed

    Percival, Donald B

    2016-04-01

    The origins of the Allan variance trace back 50 years ago to two seminal papers, one by Allan (1966) and the other by Barnes (1966). Since then, the Allan variance has played a leading role in the characterization of high-performance time and frequency standards. Wavelets first arose in the early 1980s in the geophysical literature, and the discrete wavelet transform (DWT) became prominent in the late 1980s in the signal processing literature. Flandrin (1992) briefly documented a connection between the Allan variance and a wavelet transform based upon the Haar wavelet. Percival and Guttorp (1994) noted that one popular estimator of the Allan variance-the maximal overlap estimator-can be interpreted in terms of a version of the DWT now widely referred to as the maximal overlap DWT (MODWT). In particular, when the MODWT is based on the Haar wavelet, the variance of the resulting wavelet coefficients-the wavelet variance-is identical to the Allan variance when the latter is multiplied by one-half. The theory behind the wavelet variance can thus deepen our understanding of the Allan variance. In this paper, we review basic wavelet variance theory with an emphasis on the Haar-based wavelet variance and its connection to the Allan variance. We then note that estimation theory for the wavelet variance offers a means of constructing asymptotically correct confidence intervals (CIs) for the Allan variance without reverting to the common practice of specifying a power-law noise type a priori. We also review recent work on specialized estimators of the wavelet variance that are of interest when some observations are missing (gappy data) or in the presence of contamination (rogue observations or outliers). It is a simple matter to adapt these estimators to become estimators of the Allan variance. Finally we note that wavelet variances based upon wavelets other than the Haar offer interesting generalizations of the Allan variance.

  11. Estimating the Modified Allan Variance

    NASA Technical Reports Server (NTRS)

    Greenhall, Charles

    1995-01-01

    A paper at the 1992 FCS showed how to express the modified Allan variance (mvar) in terms of the third difference of the cumulative sum of time residuals. Although this reformulated definition was presented merely as a computational trick for simplifying the calculation of mvar estimates, it has since turned out to be a powerful theoretical tool for deriving the statistical quality of those estimates in terms of their equivalent degrees of freedom (edf), defined for an estimator V by edf V = 2(EV)2/(var V). Confidence intervals for mvar can then be constructed from levels of the appropriate 2 distribution.

  12. Cornelia de lange syndrome

    PubMed Central

    Tayebi, Naeimeh

    2008-01-01

    BACKGROUND: Cornelia de Lange syndrome (CDLS) is a rare multiple congenital anomaly syndrome characterized by a distinctive facial appearance, developmental delay, growth retardation, low birth weight, skeletal formation anomaly, and hirsutism. CASE: Here for the first time a case of CDLS from Iran, a 15-week-old male infant who was refereed as a case of multiple congenital anomalies. Clinical investigation showed that the child was a case of CDLS. CONCLUSION: This is the first case report with CDLS in Iran. PMID:20300288

  13. Genetics Home Reference: Cornelia de Lange syndrome

    MedlinePlus

    ... autism, a developmental condition that affects communication and social interaction. Additional signs and symptoms of Cornelia de Lange ... de Lange Syndrome (CdLS) Genetics Education Materials for School Success (GEMSS) MalaCards: cornelia de lange syndrome 1 ...

  14. "Migrant Mother" by Dorothea Lange.

    ERIC Educational Resources Information Center

    Henry, Carole

    1995-01-01

    Maintains that the photograph, "Migrant Mother," is recognized throughout the world. Provides a three-part instructional unit on Dorothea Lange and social issues related to migrant workers. Includes four photographs by Lange, including the most well-known, "Migrant Mother 5." (CFR)

  15. Cornelia de Lange syndrome.

    PubMed

    Liu, Jinglan; Baynam, Gareth

    2010-01-01

    Cornelia de Lange syndrome (CdLS) (OMIM # 122470, #300590 and #610759) is an autosomal dominant disorder that is classically characterized by typical facial features, growth and mental retardation, upper limb defects, hirsutism, gastrointestinal and other visceral system involvement. Heterozygous mutations in the cohesin regulator, NIPBL, or the cohesin structural components SMC1A and SMC3, have been identified in approximately 65% of individuals with CdLS. Cohesin regulates sister chromatid cohesion during the mitotis and meiosis. In addition, cohesin has been demonstrated to play a critical role in the regulation of gene expression. Furthermore, multiple proteins in the cohesin pathway are also involved in additional fundamental biological events such as double strand DNA break repair, chromatin remodeling and maintaining genomic stability. Here, we will discuss the biology ofcohesin and its associated factors, with emphasis on the clinical manifestations of CdLS and mechanistic studies of the CdLS related proteins.

  16. Edgar Allan Poe's Physical Cosmology

    NASA Astrophysics Data System (ADS)

    Cappi, Alberto

    1994-06-01

    In this paper I describe the scientific content of Eureka, the prose poem written by Edgar Allan Poe in 1848. In that work, starting from metaphysical assumptions, Poe claims that the Universe is finite in an infinite Space, and that it was originated from a primordial Particle, whose fragmentation under the action of a repulsive force caused a diffusion of atoms in space. I will show that his subsequently collapsing universe represents a scientifically acceptable Newtonian model. In the framework of his evolving universe, Poe makes use of contemporary astronomical knowledge, deriving modern concepts such as a primordial atomic state of the universe and a common epoch of galaxy formation. Harrison found in Eureka the first, qualitative solution of the Olbers' paradox; I show that Poe also applies in a modern way the anthropic principle, trying to explain why the Universe is so large.

  17. Cornelia de Lange Syndrome Foundation

    MedlinePlus

    ... Volunteer Recognition de Lange Society Donate Now Donation Options Celebration and Memorial Gifts Planned Giving Monthly Giving Corporate Partnership Matching Gifts Stocks, Trusts and Other Gifts 21st Century Conference Fund ...

  18. Cornelia de Lange syndrome.

    PubMed

    Boyle, M I; Jespersgaard, C; Brøndum-Nielsen, K; Bisgaard, A-M; Tümer, Z

    2015-07-01

    Cornelia de Lange syndrome (CdLS; MIM #122470, 300590, 610759, 614701, 300882) is a rare and clinically variable disorder that affects multiple organs. It is characterized by intellectual disability (mild to severe), distinctive facial features, prenatal and postnatal growth retardation, and hirsutism. Congenital anomalies include malformations of the upper limbs, gastrointestinal malformation/rotation, pyloric stenosis, diaphragmatic hernia, heart defects and genitourinary malformations. Gastroesophageal reflux disease is present in almost all patients. In addition to classic forms, milder phenotypes have been reported. To date five genes [NIPBL (Nipped-B-like protein), SMC1A (structural maintenance of chromosomes 1A), SMC3 (structural maintenance of chromosomes 3), RAD21 (human homolog of Schizosaccharomyces pombe radiation sensitive mutant 21) and HDAC8 (histone deacetylase 8)] have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients. Here, we will provide a brief review of the clinical features of CdLS, summarize the known underlying genetic defects, prenatal and postnatal diagnosis possibilities, and genetic counseling. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Low-loss Lange coupler

    NASA Astrophysics Data System (ADS)

    Hobdell, J. L.; Biggin, J. W.; Band, K. S.

    1982-09-01

    The Lange coupler is used to make hybrid 3 dB couplers. In order to equalize the odd- and even-mode phase velocities, bond wires have to be used to join alternate lines of the coupler. In monolithic circuits the incorporation of bond wires is not possible, and techniques have been developed which involve the replacement of bond wires by air bridges. The present investigation is concerned with a comparison of the loss associated with air-bridge and wire-bonded couplers on alumina. It is found that the use of air-bridge straps on Lange couplers constructed on alumina gives couplers with a transmission loss which is lower than that observed in the case of an identical coupler using bond wires. The air-bridge technique also makes the mass production of circuits employing Lange couplers easier. The assembly step of bonding the coupler is eliminated at the expense of an extra fabrication step.

  20. SIM-Lite Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael

    2008-01-01

    Discussion focus on: SIM-Lite Instrument Update - 6m baseline, 50cm, approximately 900M cost; Technology Update - Systematic errors and floor; SIM-Lite terrestrial planet discovery capability; Double blind multiple planet study summary; and the changing landscape of exoplanet science and the role of SIM-Lite. Slides include technology to flight component engineering; instrumental systematic errors; ultra deep search for Earth clones; double blind test, astrometric detection of Earths in multiplanet systems; the current era of exoplanet science and where SIM-Lite fits in; the next frontier and where SIM-Lite fits in, why SIM is unique in discovering Earths; imaging planet status is uncertain without masses and ages; SIM role in establishing how planetary systems form and evolve; and SIM probes of broad planet mass range around young stars.

  1. SIM-Lite Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael

    2008-01-01

    Discussion focus on: SIM-Lite Instrument Update - 6m baseline, 50cm, approximately 900M cost; Technology Update - Systematic errors and floor; SIM-Lite terrestrial planet discovery capability; Double blind multiple planet study summary; and the changing landscape of exoplanet science and the role of SIM-Lite. Slides include technology to flight component engineering; instrumental systematic errors; ultra deep search for Earth clones; double blind test, astrometric detection of Earths in multiplanet systems; the current era of exoplanet science and where SIM-Lite fits in; the next frontier and where SIM-Lite fits in, why SIM is unique in discovering Earths; imaging planet status is uncertain without masses and ages; SIM role in establishing how planetary systems form and evolve; and SIM probes of broad planet mass range around young stars.

  2. Brachmann-de Lange syndrome

    SciTech Connect

    Ackerman, J.; Gilbert-Barness, E.

    1997-01-31

    This report describes an infant with Brachmann-de Lange syndrome and the diagnosis of this disease in utero. It also discusses the future ability to rely on chromosome 9-associated levels of pregnancy-associated plasma protein A (PAPPA) as an indicator of the disease, rather than solely relying on the phenotype of the fetus as determined during ultrasound. 3 refs., 2 figs.

  3. John A. Scigliano Interviews Allan B. Ellis.

    ERIC Educational Resources Information Center

    Scigliano, John A.

    2000-01-01

    This interview with Allan Ellis focuses on a history of computer applications in education. Highlights include work at the Harvard Graduate School of Education; the New England Education Data System; and efforts to create a computer-based distance learning and development program called ISVD (Information System for Vocational Decisions). (LRW)

  4. Allan-Herndon syndrome. I. Clinical studies.

    PubMed Central

    Stevenson, R E; Goodman, H O; Schwartz, C E; Simensen, R J; McLean, W T; Herndon, C N

    1990-01-01

    A large family with X-linked mental retardation, originally reported in 1944 by Allan, Herndon, and Dudley, has been reinvestigated. Twenty-nine males have been affected in seven generations. Clinical features include severe mental retardation, dysarthria, ataxia, athetoid movements, muscle hypoplasia, and spastic paraplegia with hyperreflexia, clonus, and Babinski reflexes. The facies appear elongated with normal head circumference, bitemporal narrowing, and large, simple ears. Contractures develop at both small and large joint. Statural growth is normal and macroorchidism does not occur. Longevity is not impaired. High-resolution chromosomes, serum creatine kinase, and amino acids are normal. This condition, termed the Allan-Herndon syndrome, appears distinct from other X-linked disorders having mental retardation, muscle hypoplasia, and spastic paraplegia. Images Figure 2 Figure 3 PMID:2393019

  5. [The medical history of Edgar Allan Poe].

    PubMed

    Miranda C, Marcelo

    2007-09-01

    Edgar Allan Poe, one of the best American storytellers and poets, suffered an episodic behaviour disorder partially triggered by alcohol and opiate use. Much confusion still exists about the last days of his turbulent life and the cause of his death at an early age. Different etiologies have been proposed to explain his main medical problem, however, complex partial seizures triggered by alcohol, poorly recognized at the time when Poe lived, seems to be one of the most acceptable hypothesis, among others discussed.

  6. The Cosmology of Edgar Allan Poe

    NASA Astrophysics Data System (ADS)

    Cappi, Alberto

    2011-06-01

    Eureka is a ``prose poem'' published in 1848, where Edgar Allan Poe presents his original cosmology. While starting from metaphysical assumptions, Poe develops an evolving Newtonian model of the Universe which has many and non casual analogies with modern cosmology. Poe was well informed about astronomical and physical discoveries, and he was influenced by both contemporary science and ancient ideas. For these reasons, Eureka is a unique synthesis of metaphysics, art and science.

  7. The SIM Time Network

    PubMed Central

    Lombardi, Michael A.; Novick, Andrew N.; Lopez R, J. Mauricio; Jimenez, Francisco; de Carlos Lopez, Eduardo; Boulanger, Jean-Simon; Pelletier, Raymond; de Carvalho, Ricardo J.; Solis, Raul; Sanchez, Harold; Quevedo, Carlos Andres; Pascoe, Gregory; Perez, Daniel; Bances, Eduardo; Trigo, Leonardo; Masi, Victor; Postigo, Henry; Questelles, Anthony; Gittens, Anselm

    2011-01-01

    The Sistema Interamericano de Metrologia (SIM) is a regional metrology organization (RMO) whose members are the national metrology institutes (NMIs) located in the 34 nations of the Organization of American States (OAS). The SIM/OAS region extends throughout North, Central, and South America and the Caribbean Islands. About half of the SIM NMIs maintain national standards of time and frequency and must participate in international comparisons in order to establish metrological traceability to the International System (SI) of units. The SIM time network (SIMTN) was developed as a practical, cost effective, and technically sound way to automate these comparisons. The SIMTN continuously compares the time standards of SIM NMIs and produces measurement results in near real-time by utilizing the Internet and the Global Positioning System (GPS). Fifteen SIM NMIs have joined the network as of December 2010. This paper provides a brief overview of SIM and a technical description of the SIMTN. It presents international comparison results and examines the measurement uncertainties. It also discusses the metrological benefits that the network provides to its participants. PMID:26989584

  8. The SIM Time Network.

    PubMed

    Lombardi, Michael A; Novick, Andrew N; Lopez R, J Mauricio; Jimenez, Francisco; de Carlos Lopez, Eduardo; Boulanger, Jean-Simon; Pelletier, Raymond; de Carvalho, Ricardo J; Solis, Raul; Sanchez, Harold; Quevedo, Carlos Andres; Pascoe, Gregory; Perez, Daniel; Bances, Eduardo; Trigo, Leonardo; Masi, Victor; Postigo, Henry; Questelles, Anthony; Gittens, Anselm

    2011-01-01

    The Sistema Interamericano de Metrologia (SIM) is a regional metrology organization (RMO) whose members are the national metrology institutes (NMIs) located in the 34 nations of the Organization of American States (OAS). The SIM/OAS region extends throughout North, Central, and South America and the Caribbean Islands. About half of the SIM NMIs maintain national standards of time and frequency and must participate in international comparisons in order to establish metrological traceability to the International System (SI) of units. The SIM time network (SIMTN) was developed as a practical, cost effective, and technically sound way to automate these comparisons. The SIMTN continuously compares the time standards of SIM NMIs and produces measurement results in near real-time by utilizing the Internet and the Global Positioning System (GPS). Fifteen SIM NMIs have joined the network as of December 2010. This paper provides a brief overview of SIM and a technical description of the SIMTN. It presents international comparison results and examines the measurement uncertainties. It also discusses the metrological benefits that the network provides to its participants.

  9. Allan R. Sanford (1927–2016)

    DOE PAGES

    Hartse, Hans Edward

    2016-12-07

    Allan (Al) R. Sanford, professor of geophysics, emeritus, at New Mexico Tech (NMT) passed away quietly at his home in Woodinville, WA on August 9, 2016. He was 89. Al was a pioneer in the recording and interpretation of microearthquake seismograms. For decades he was the leading authority concerning seismicity across New Mexico and within the Rio Grande Rift (RGR). He published numerous papers with graduate students and colleagues on the unique, high-amplitude reflected phases seen on Socorro-area microearthquake records.

  10. Radio-Echo Sounding in the Allan Hills, Antarctica, in Support of the Meteorite Field Program.

    DTIC Science & Technology

    1980-05-01

    ice. The results also revealed internal layering within the snow on Ross Island and in the snow filling an ice depres- sion west of Allan Nunatak ...Radio-echo sounding also gave the depth to bedrock near the west side of Allan Nunatak . The greatest ice depth measured was 310 m. • . 9Q3...Institute of Polar Research had installed across the blue ice surface extending westward from the Allan Nunatak . Allan Nunatak is located in the Allan

  11. Uranium series dating of Allan Hills ice

    NASA Technical Reports Server (NTRS)

    Fireman, E. L.

    1986-01-01

    Uranium-238 decay series nuclides dissolved in Antarctic ice samples were measured in areas of both high and low concentrations of volcanic glass shards. Ice from the Allan Hills site (high shard content) had high Ra-226, Th-230 and U-234 activities but similarly low U-238 activities in comparison with Antarctic ice samples without shards. The Ra-226, Th-230 and U-234 excesses were found to be proportional to the shard content, while the U-238 decay series results were consistent with the assumption that alpha decay products recoiled into the ice from the shards. Through this method of uranium series dating, it was learned that the Allen Hills Cul de Sac ice is approximately 325,000 years old.

  12. Allan Urho Paivio (1925-2016).

    PubMed

    Katz, Albert

    2017-01-01

    Presents an obituary for Allan Urho Paivio, who passed away on June 19, 2016. One of his many accomplishments was the development of a dual-coding theory. Dual-coding theory, while very influential, has, unfortunately, been discussed all too often as a theory of mental imagery, and not within its larger context wherein mental imagery and verbal processes are separable but interconnected representational systems, an academic battle in clarification that Paivio waged much of his life. He published prodigiously, even in the decades after retirement. Among his many honors, he served as president of the Canadian Psychological Association (1975) and was appointed a fellow of the Royal Society of Canada (1978). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  13. Uranium series dating of Allan Hills ice

    NASA Technical Reports Server (NTRS)

    Fireman, E. L.

    1986-01-01

    Uranium-238 decay series nuclides dissolved in Antarctic ice samples were measured in areas of both high and low concentrations of volcanic glass shards. Ice from the Allan Hills site (high shard content) had high Ra-226, Th-230 and U-234 activities but similarly low U-238 activities in comparison with Antarctic ice samples without shards. The Ra-226, Th-230 and U-234 excesses were found to be proportional to the shard content, while the U-238 decay series results were consistent with the assumption that alpha decay products recoiled into the ice from the shards. Through this method of uranium series dating, it was learned that the Allen Hills Cul de Sac ice is approximately 325,000 years old.

  14. Otolaryngological presentations of Cornelia de Lange syndrome.

    PubMed

    Hamilton, Jane; Clement, W Andrew; Kubba, Haytham

    2014-09-01

    Children with Cornelia de Lange syndrome frequently present to otolaryngology services with hearing problems. Airway problems have not previously been reported. We wish to describe our experience of the overall management in a series of children with Cornelia de Lange syndrome. Retrospective case note review of children diagnosed with Cornelia de Lange syndrome presenting to our department between 2005 and 2014. Six patients were seen. Airway problems consisted of laryngeal overspill with severe gastroesophageal dysmotility and reflux despite structurally normal airway (1 case), laryngomalacia requiring supraglottoplasty (2 cases), reflux laryngitis with secondary laryngomalacia and coincidental tracheal diverticulum (1 case) choanal atresia requiring stents (1 case) and obstructive sleep apnoea (1 case). Supraglottoplasty produced a dramatic improvement in feeding and breathing in both children who underwent the procedure. Two children had palatal anomalies and one underwent cochlear implantation for a profound sensorineural hearing loss. Children with Cornelia de Lange syndrome have multifaceted ENT problems. Airway pathology has not previously been described in Cornelia de Lange syndrome but has been common in our experience. We wish to highlight that laryngomalacia in Cornelia de Lange syndrome responds well to supraglottoplasty. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  15. 32. SCIENTISTS ALLAN COX (SEATED), RICHARD DOELL, AND BRENT DALRYMPLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. SCIENTISTS ALLAN COX (SEATED), RICHARD DOELL, AND BRENT DALRYMPLE AT CONTROL PANEL, ABOUT 1965. - U.S. Geological Survey, Rock Magnetics Laboratory, 345 Middlefield Road, Menlo Park, San Mateo County, CA

  16. CrossSim

    SciTech Connect

    Plimpton, Steven J.; Agarwal, Sapan; Schiek, Richard; Richter, Isaac

    2016-09-02

    CrossSim is a simulator for modeling neural-inspired machine learning algorithms on analog hardware, such as resistive memory crossbars. It includes noise models for reading and updating the resistances, which can be based on idealized equations or experimental data. It can also introduce noise and finite precision effects when converting values from digital to analog and vice versa. All of these effects can be turned on or off as an algorithm processes a data set and attempts to learn its salient attributes so that it can be categorized in the machine learning training/classification context. CrossSim thus allows the robustness, accuracy, and energy usage of a machine learning algorithm to be tested on simulated hardware.

  17. Allan Hills Pleistocene Ice Project (PIP)

    NASA Astrophysics Data System (ADS)

    Kurbatov, A.; Brook, E.; Campbell, S. W.; Conway, H.; Dunbar, N. W.; Higgins, J. A.; Iverson, N. A.; Kehrl, L. M.; McIntosh, W. C.; Spaulding, N. E.; Yan, Y.; Mayewski, P. A.

    2016-12-01

    A major international effort to identify at least 1.5 Ma old ice for paleoclimate reconstructions has successfully resulted in the selection of several potential drill sites in East Antarctica. At this point it is indisputable that the Antarctic ice sheet captures a continuous envinronmental record of the Earth that spans the Mid Pleistocene Transition (MPT). In addition to traditional ice coring approaches, the oldest ice can also be recovered in Antarctic Blue Ice Areas (BIA). We have already successfully demonstrated that the Allan Hills (AH) BIA captures a regional climate signal and robust record of 1Ma atmosphere that can be studied with a relatively uncomplicated logistical imprint and essentially unlimited sampling volume. The attractiveness of unlimited sampling of known age ice is the basis for the "ice park" concept proposed earlier by our research team. The idea is that, once the age of ice exposed along the flow line at the surface of BIA is mapped, it could be sampled for numerous research projects as needed. Here we propose an intermediate ( 1,150 m deep) ice core drill site, located only 240 km away from McMurdo base that will help to develop a, continuous, high quality regional paleoclimate record that is at least 1Ma old. We will introduce and discuss the glaciological settings, paleoclimate signals and possible limitations and advantages of the 1 Ma AH BIA regional paleoclimate record. The research was funded by NSF Division of Polar Programs.

  18. Allan deviation analysis of financial return series

    NASA Astrophysics Data System (ADS)

    Hernández-Pérez, R.

    2012-05-01

    We perform a scaling analysis for the return series of different financial assets applying the Allan deviation (ADEV), which is used in the time and frequency metrology to characterize quantitatively the stability of frequency standards since it has demonstrated to be a robust quantity to analyze fluctuations of non-stationary time series for different observation intervals. The data used are opening price daily series for assets from different markets during a time span of around ten years. We found that the ADEV results for the return series at short scales resemble those expected for an uncorrelated series, consistent with the efficient market hypothesis. On the other hand, the ADEV results for absolute return series for short scales (first one or two decades) decrease following approximately a scaling relation up to a point that is different for almost each asset, after which the ADEV deviates from scaling, which suggests that the presence of clustering, long-range dependence and non-stationarity signatures in the series drive the results for large observation intervals.

  19. Dental findings in Cornelia de Lange syndrome.

    PubMed

    Toker, Aslihan Soyal; Ay, Sinan; Yeler, Hasan; Sezgin, Ilhan

    2009-04-30

    Cornelia de Lange syndrome is a congenital disease, basically characterized by psychomotor retardation associated with a series of malformations, including mainly skeletal, craniofacial deformities together with gastrointestinal and cardiac malformations. There is no definitive biochemical or chromosomal marker for the prenatal diagnosis of this syndrome. We actually want to present the case of a 10-year-old patient, who was admitted to our clinic for dental pain. The patient had the symptoms of Cornelia de Lange syndrome. During the oral examination of this patient, the patient was found to have the typical symptoms of Cornelia de Lange syndrome, such as micrognathia and delayed eruption in conjunction with the symptoms of the Hutchinson's syndrome, which had never been reported before.

  20. SIM Configuration Evolution

    NASA Technical Reports Server (NTRS)

    Aaron, Kim M.

    2000-01-01

    The Space Interferometry Mission (SIM) is a space-based 10 m baseline Michelson interferometer. Planned for launch in 2005 aboard a Delta III launch vehicle, or equivalent, its primary objective is to measure the positions of stars and other celestial objects with an unprecedented accuracy of 4 micro arc seconds. With such an instrument, tremendous advancement can be expected in our understanding of stellar and galactic dynamics. Using triangulation from opposite sides of the orbit around the sun (i.e. by using parallax) one can measure the distance to any observable object in our galaxy. By directly measuring the orbital wobble of nearby stars, the mass and orbit of planets can be determined over a wide range of parameters. The distribution of velocity within nearby galaxies will be measurable. Observations of these and other objects will improve the calibration of distance estimators by more than an order of magnitude. This will permit a much better determination of the Hubble Constant as well as improving our overall understanding of the evolution of the universe. SIM has undergone several transformations, especially over the past year and a half since the start of Phase A. During this phase of a project, it is desirable to perform system-level trade studies, so the substantial evolution of the design that has occurred is quite appropriate. Part of the trade-off process has addressed two major underlying architectures: SIM Classic; and Son of SIM. The difference between these two architectures is related to the overall arrangement of the optical elements and the associated metrology system. Several different configurations have been developed for each architecture. Each configuration is the result of design choices that are influenced by many competing considerations. Some of the more important aspects will be discussed. The Space Interferometry Mission has some extremely challenging goals: millikelvin thermal stability, nanometer stabilization of optics

  1. [Systemic and ophthalmological findings in Cornelia de Lange syndrome].

    PubMed

    Mrugacz, Małgorzata; Sielicka, Danuta

    2012-01-01

    Cornelia de Lange Syndrome (CdLS, de Lange syndrome, Brachmann-de Lange syndrome), is a relatively rare genetic disorder, characterized by set of clinical abnormalities concerning different organs and systems. Phenotypic diagnosis is based on a specific dysmorphic features seen after the birth. We described a genetic basis, hereditary patterns, characteristic dysmorphic features and the most common clinical findings of patients Cornelia de Lange Syndrome concerning eye and vision, hearing, cardiovascular, respiratory, gastrointestinal, genitourinary, skeletal and psychomotor development.

  2. Modal comparison of Yamato and Allan Hills polymict eucrites

    NASA Technical Reports Server (NTRS)

    Delaney, J. S.; Prinz, M.; Takeda, H.

    1983-01-01

    Seven Yamato and six Allan Hills polymict eucrite specimens were compared by modal analysis. The analyses reveal differences of plagioclase and pyroxene content between the two groups. The Yamato suite has more 'pigeonitic' pyroxene and less plagioclase and low-calcium pyroxene than the Allan Hills suite. Variations within each suite are small and three sections of Allan Hills A78040 are more variable than the Allen Hills suite considered as a group. Modal data provides a basis for pairing polymict eucrite specimens when used together with mineralogical and petrographic criteria. Modal data furthermore confirms the presence of several rock types previously identified using pyroxene crystallography and hints at the presence of an augite-rich component.

  3. Neuroimaging features of Cornelia de Lange syndrome.

    PubMed

    Whitehead, Matthew T; Nagaraj, Usha D; Pearl, Phillip L

    2015-07-01

    Cornelia de Lange syndrome is a rare genetic disease characterized by distinctive facial dysmorphia and dwarfism. Multiple organ system involvement is typical. Various central nervous system (CNS) aberrations have been described in the pathology literature; however, the spectrum of neuroimaging manifestations is less well documented. To present neuroimaging findings from a series of eight patients with Cornelia de Lange syndrome. The CT/MR database at a single academic children's hospital was searched for the terms "Cornelia," "Brachmann" and "de Lange." The search yielded 18 exams from 16 patients. Two non-CNS and six exams without available images were excluded. Ten exams from eight patients were evaluated by a board-certified neuroradiologist. All patients had skull base dysplasia, most with an unusual coronal basioccipital cleft (7/8). All brain MR exams showed microcephaly, volume loss and gyral simplification (5/5). Six patients had an absent massa intermedia. Four patients had small globe anterior segments; three had optic pathway hypoplasia. Basilar artery fenestration was present in two patients; vertebrobasilar hypoplasia was present in one patient. The inner ear vestibules were dysplastic in two patients. One patient had pachymeningeal thickening. Spinal anomalies included scoliosis, segmentation anomalies, endplate irregularities, basilar invagination, foramen magnum stenosis and tethered spinal cord. Typical imaging manifestations of Cornelia de Lange syndrome include skull base dysplasia with coronal clival cleft, cerebral and brainstem volume loss, and gyral simplification. Membranous labyrinth dysplasia, anterior segment and optic pathway hypoplasia, basilar artery fenestration, absent massa intermedia and spinal anomalies may also be present.

  4. ABR Audiometry in Cornelia De Lange Syndrome.

    ERIC Educational Resources Information Center

    Brown, Denice P.

    Eight children (ages 13 days to 5 years) with a diagnosis of Cornelia de Lange syndrome received audiologic evaluation consisting of immittance audiometry and auditory brainstem response audiometry to air and bone conducted "click" stimuli, as behavioral testing was unreliable due to patient age and/or developmental delay. Developmental…

  5. De Lange Syndrome: Report of 20 Cases

    PubMed Central

    McArthur, R. G.; Edwards, J. H.

    1967-01-01

    Typus Degenerativus Amstelodamensis or Amsterdam dwarfism, a syndrome of unknown etiology characterized by mental retardation, a distinctive face, characteristic hands and feet, defective growth and other minor malformations, was first described by Cornelia de Lange in 1933. Approximately 69 cases, including nine autopsies, have been reported in the literature. In this paper we present a further 20, with illustrations of the syndrome from infancy to puberty (including de Lange's original three cases). The historical, physical, laboratory and radiographic findings of de Lange's three patients and our 20 are tabulated. Autopsy findings in one of our patients are reported and the literature is briefly reviewed. Although some observers have recently reported chromosome abnormalities in de Lange's syndrome, we feel that the diagnosis is made from the history and physical examination and that there are no definitive laboratory aids which can confirm the diagnosis. Chromosome studies in all 20 of our patients were normal and the genetic implications are discussed. ImagesFig. 1Fig. 2Fig. 3Fig. 4Fig. 5Fig. 6Fig. 9Fig. 11p1197-a PMID:6022788

  6. ABR Audiometry in Cornelia De Lange Syndrome.

    ERIC Educational Resources Information Center

    Brown, Denice P.

    Eight children (ages 13 days to 5 years) with a diagnosis of Cornelia de Lange syndrome received audiologic evaluation consisting of immittance audiometry and auditory brainstem response audiometry to air and bone conducted "click" stimuli, as behavioral testing was unreliable due to patient age and/or developmental delay. Developmental…

  7. The Allan Hills icefield and its relationship to meteorite concentration

    NASA Technical Reports Server (NTRS)

    Annexstad, J. O.

    1982-01-01

    The Allan Hills icefield is described by as a limited icefield that has large concentrations of meteorites. The meteorites appear to be concentrated on the lower limb of an ice monocline with other finds scattered throughout the field. In an attempt to understand the mechanisms of meteorite concentration, a triangulation chain was established across the icefield. This chain is composed of 20 stations, two of which are on bedrock, and extends westward from the Allan Hills a distance of 15 kilometers. The triangulation chain and its relationship to the meteorite concentrations is shown.

  8. Allan Hills 77005 - A new meteorite type found in Antarctica

    NASA Technical Reports Server (NTRS)

    Mcsween, H. Y., Jr.; Taylor, L. A.; Stolper, E. M.

    1979-01-01

    A unique 482.5 g meteorite found in Antarctica appears to be related by igneous differentiation to shergottite achondrites, which have close similarities with terrestrial basaltic rocks. Zoned maskelynite with similar compositional ranges and plagioclase of such intermediate compositions as are unknown in other achondrites occur in both shergottites and the Allan Hills meteorite. The degree of silica saturation, however, strongly distinguishes the two meteorite types. It is suggested that the Allan Hills meteorite may represent a cumulate rock formed earlier than the shergottites from the same or a similar parent magma.

  9. Obituary: Allan R. Sandage (1926-2010)

    NASA Astrophysics Data System (ADS)

    Devorkin, David

    2011-12-01

    Allan Rex Sandage died of pancreatic cancer at his home in San Gabriel, California, in the shadow of Mount Wilson, on November 13, 2010. Born in Iowa City, Iowa, on June 18, 1926, he was 84 years old at his death, leaving his wife, former astronomer Mary Connelly Sandage, and two sons, David and John. He also left a legacy to the world of astronomical knowledge that has long been universally admired and appreciated, making his name synonymous with late 20th-Century observational cosmology. The only child of Charles Harold Sandage, a professor of advertising who helped establish that academic specialty after obtaining a PhD in business administration, and Dorothy Briggs Sandage, whose father was president of Graceland College in Iowa, Allan Sandage grew up in a thoroughly intellectual, university oriented atmosphere but also a peripatetic one taking him to Philadelphia and later to Illinois as his father rose in his career. During his 2 years in Philadelphia, at about age eleven, Allan developed a curiosity about astronomy stimulated by a friend's interest. His father bought him a telescope and he used it to systematically record sunspots, and later attempted to make a larger 6-inch reflector, a project left uncompleted. As a teenager Allan read widely, especially astronomy books of all kinds, recalling in particular The Glass Giant of Palomar as well as popular works by Eddington and Hubble (The Realm of the Nebulae) in the early 1940s. Although his family was Mormon, of the Reorganized Church, he was not practicing, though he later sporadically attended a Methodist church in Oxford, Iowa during his college years. Sandage knew by his high school years that he would engage in some form of intellectual life related to astronomy. He particularly recalls an influential science teacher at Miami University in Oxford, Ohio named Ray Edwards, who inspired him to think critically and "not settle for any hand-waving of any kind." [Interview of Allan Rex Sandage by Spencer

  10. The HexSim Model

    EPA Science Inventory

    HexSim version 2.0 is soon to be released by EPA's Western Ecology Division (WED). More than three years of work have gone into the development of this tool, which grew out of an EPA model called PATCH. HexSim makes it possible for non-programmers to develop sophisticated simula...

  11. The HexSim Model

    EPA Science Inventory

    HexSim version 2.0 is soon to be released by EPA's Western Ecology Division (WED). More than three years of work have gone into the development of this tool, which grew out of an EPA model called PATCH. HexSim makes it possible for non-programmers to develop sophisticated simula...

  12. Numbers Of Degrees Of Freedom Of Allan-Variance Estimators

    NASA Technical Reports Server (NTRS)

    Greenhall, Charles A.

    1992-01-01

    Report discusses formulas for estimation of Allan variances. Presents algorithms for closed-form approximations of numbers of degrees of freedom characterizing results obtained when various estimators applied to five power-law components of classical mathematical model of clock noise.

  13. Biotechnology Symposium - In Memoriam, the Late Dr. Allan Zipf

    USDA-ARS?s Scientific Manuscript database

    A one-day biotechnology symposium was held at Alabama A&M University (AAMU), Normal, AL on June 4, 2004 in memory of the late Dr. Allan Zipf (Sept 1953-Jan 2004). Dr. Zipf was a Research Associate Professor at the Department of Plant and Soil Sciences, AAMU, who collaborated extensively with ARS/MS...

  14. Allan Variance Calculation for Nonuniformly Spaced Input Data

    DTIC Science & Technology

    2015-01-01

    Approved for public release; distribution is unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT The Allan Variance ( AV ) characterizes the...temporal randomness in sensor output data streams at various times scales. The conventional formula for calculating the AV assumes that the data...presents a modified approach to AV calculation, which accommodates nonuniformly spaced time samples. The basic concept of the modified approach is

  15. Allan Sandage : L'architecte de l'expansion

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1998-07-01

    Il fut de cette poignee de pionniers qui ouvrirent le monde extragalactique. Depuis pres de 50 ans, Allan Sandage poursuit la quete amorcee par le "maitre" Edwin Hubble : mesurer le taux d'expansion de l'Univers. Rencontre avec une legende vivante de la cosmologie...

  16. Social Anxiety in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Richards, Caroline; Moss, Jo; O'Farrell, Laura; Kaur, Gurmeash; Oliver, Chris

    2009-01-01

    In this study we assessed the behavioral presentation of social anxiety in Cornelia de Lange syndrome (CdLS) using a contrast group of Cri du Chat syndrome (CdCS). Behaviors indicative of social anxiety were recorded in twelve children with CdLS (mean age = 11.00; SD = 5.15) and twelve children with CdCS (8.20; SD = 2.86) during social…

  17. Social Anxiety in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Richards, Caroline; Moss, Jo; O'Farrell, Laura; Kaur, Gurmeash; Oliver, Chris

    2009-01-01

    In this study we assessed the behavioral presentation of social anxiety in Cornelia de Lange syndrome (CdLS) using a contrast group of Cri du Chat syndrome (CdCS). Behaviors indicative of social anxiety were recorded in twelve children with CdLS (mean age = 11.00; SD = 5.15) and twelve children with CdCS (8.20; SD = 2.86) during social…

  18. Obituary: Andrew Lange (1957-2010)

    NASA Astrophysics Data System (ADS)

    Kamionkowski, Marc

    2011-12-01

    The worlds of physics and astrophysics were stunned to learn on 22 January 2010 that Andrew Lange, the Marvin L. Goldberger Professor of Physics at Caltech, had taken his own life the night before. He had succumbed to the severe depression that he had suffered from for many years, unbeknownst to even his closest colleagues. Lange will perhaps be best remembered as the co-leader of Boomerang, the balloon-borne experiment that provided the first high-angular-resolution map of the cosmic microwave background (CMB). And while this was certainly his most notable achievement, Andrew amassed a record of accomplishment as an instrumentalist, leader, mentor, and communicator that extended much further. Andrew was born in Urbana, Illinois on July 23, 1957, the son of an architect and a librarian, and raised primarily in Connecticut. His family and early friends remember him as a serious and extremely intelligent child and young man. Andrew Lange's lifelong interest in the CMB was nurtured as an undergraduate at Princeton University by David Wilkinson, and he recalled fondly a summer spent working with John Mather at Goddard Space Flight Center. Andrew Lange went to graduate school in physics at Berkeley where he worked in Paul Richards' group. Although his thesis project, the Berkeley-Nagoya rocket experiment, showed an anomalous sub-millimeter excess in the CMB spectrum that was shortly thereafter shown by a later flight of the same rocket and COBE-FIRAS to be incorrect, Lange's talents were recognized by the physics department at Berkeley who appointed him shortly after his PhD (1987) to their faculty. While on the Berkeley faculty, Andrew obtained early detections of the Sunyaev-Zeldovich effect, upper limits to small-angle CMB fluctuations, and important infrared constraints to the interstellar medium. He also led a pioneering instrument operating 300 mK detectors for a small infrared satellite experiment. This early work showed high ambition and daring, and it pioneered

  19. Draft INFL Guideline on SIMS

    SciTech Connect

    Kristo, M J

    2012-04-02

    Secondary Ion Mass Spectrometry (SIMS) is used for elemental and isotopic analysis of solid samples. The greatest strength of SIMS is the ability to analyze very small areas (as small as 50 nm using the CAMECA NanoSIMS, for example) and to generate high-spatial resolution maps of the distribution of elements and isotopes within the sample. The measurement of the isotopic composition of sample is usually straightforward, only requiring the analysis of the sample and that of an isotopic reference material for determination of the mass bias of the instrument. Quantification of elements, however, involves the analysis of matrix matched standards for the determination of the relative sensitivity factor (a function of both the element to be analyzed and the matrix). SIMS is commonly used in nuclear forensics for exploring the heterogeneity of the material on fine spatial scale.

  20. SIM Measurements Near and Far

    NASA Astrophysics Data System (ADS)

    Patterson, Richard J.; Anglada, G.; Kaplinghat, M.; Kuchner, M. J.; Olling, R.

    2010-01-01

    The results from four SIM Science Studies are presented. The "GAIA-SIM Legacy Project" analyzes the long-term astrometric benefits that arise from the currently sequential ordering of the GAIA and SIM missions. Several issues will affect any attempts to utilize the combined datasets, such as the reference frames used, and the precise coordinate definition of the observable quantities in both missions. The second project "Determining the nature of dark matter using proper motions of stars in the Milky Way satellites" is focused on developing methods that would allow the interpretation of SIM observations of these targets in order to derive the slope of the density of dark matter near the centers of dwarf spheroidal galaxies. Since steep density cusps are predicted from cold dark matter models, and shallow density slopes are expected in warm dark matter models, these observations should allow one to determine the microphysical properties of the dark matter particle. "Sizes and Shapes of Kuiper Belt Objects and Centaurs with SIM" investigated the use of SIM to target these primordial solar system objects, in order to measure precise sizes and shapes. This will involve using non-sidereal tracking, as well as visibility measurements using the co-linear guide interferometer baseline. The fourth project "1% Luminoisty-Independent Distances to nearby Galaxies with the Rotational Parallax Technique" investigates the use of this geometric method that can be used to sample a large part of the stellar disk of external galaxies (which allows non-axisymmetric motions to be determined). Accurate RP distances will facilitate detailed comparisons between almost all standard candles (MW, M31, M33, LMC, and NGC 4258). These cross-checks are crucial if we are to believe galaxy distances (and H0) at the 1% level. The SIM Science studies have been funded by the SIM Project Office, NASA/JPL.

  1. Exposure and terrestrial ages of four Allan Hills Antarctic meteorites

    NASA Technical Reports Server (NTRS)

    Kirsten, T.; Ries, D.; Fireman, E. L.

    1978-01-01

    Terrestrial ages of meteorites are based on the amount of cosmic-ray-produced radioactivity in the sample and the number of observed falls that have similar cosmic-ray exposure histories. The cosmic-ray exposures are obtained from the stable noble gas isotopes. Noble gas isotopes are measured by high-sensitivity mass spectrometry. In the present study, the noble gas contents were measured in four Allan Hill meteorites (No. 5, No. 6, No. 7, and No. 8), whose C-14, Al-26, and Mn-53 radioactivities are known. These meteorites are of particular interest because they belong to a large assemblage of distinct meteorites that lie exposed on a small (110 sq km) area of ice near the Allan Hills.

  2. Carbon-14 ages of Allan Hills meteorites and ice

    NASA Technical Reports Server (NTRS)

    Fireman, E. L.; Norris, T.

    1982-01-01

    Allan Hills is a blue ice region of approximately 100 sq km area in Antarctica where many meteorites have been found exposed on the ice. The terrestrial ages of the Allan Hills meteorites, which are obtained from their cosmogenic nuclide abundances are important time markers which can reflect the history of ice movement to the site. The principal purpose in studying the terrestrial ages of ALHA meteorites is to locate samples of ancient ice and analyze their trapped gas contents. Attention is given to the C-14 and Ar-39 terrestrial ages of ALHA meteorites, and C-14 ages and trapped gas compositions in ice samples. On the basis of the obtained C-14 terrestrial ages, and Cl-36 and Al-26 results reported by others, it is concluded that most ALHA meteorites fell between 20,000 and 200,000 years ago.

  3. Degrees of Freedom for Allan Deviation Estimates of Multiple Clocks

    DTIC Science & Technology

    2016-04-01

    IEEE TRANSACTIONS ON ULTRASONICS , FERROELECTRICS, AND FREQUENCY CONTROL, VOL. 63, NO. 4, APRIL 2016 571 Degrees of Freedom for Allan Deviation... ULTRASONICS , FERROELECTRICS, AND FREQUENCY CONTROL, VOL. 63, NO. 4, APRIL 2016 The hat (ˆ) over the parameter denotes an estimated value. The single noise...TRANSACTIONS ON ULTRASONICS , FERROELECTRICS, AND FREQUENCY CONTROL, VOL. 63, NO. 4, APRIL 2016 Fig. 5. Mesh plot shows the relationship between Gamma, Beta, and

  4. The Third-Difference Approach to Modified Allan Variance

    NASA Technical Reports Server (NTRS)

    Greenhall, C. A.

    1995-01-01

    This study gives strategies for estimating the modified Allan variance (mvar) and formulas for computing the equivalent degrees of freedom (edf) of the estimators. A third-difference formulation of mvar leads to a tractable formula for edf in the presence of power-law phase noise. The effect of estimation stride on edf is tabulated. First-degree rational-function approximations for edf are derived.

  5. Measurement of Allan variance and phase noise at fractions of a millihertz

    NASA Technical Reports Server (NTRS)

    Conroy, Bruce L.; Le, Duc

    1990-01-01

    Although the measurement of Allan variance of oscillators is well documented, there is a need for a simplified system for finding the degradation of phase noise and Allan variance step-by-step through a system. This article describes an instrumentation system for simultaneous measurement of additive phase noise and degradation in Allan variance through a transmitter system. Also included are measurements of a 20-kW X-band transmitter showing the effect of adding a pass tube regulator.

  6. Allan variance of time series models for measurement data

    NASA Astrophysics Data System (ADS)

    Zhang, Nien Fan

    2008-10-01

    The uncertainty of the mean of autocorrelated measurements from a stationary process has been discussed in the literature. However, when the measurements are from a non-stationary process, how to assess their uncertainty remains unresolved. Allan variance or two-sample variance has been used in time and frequency metrology for more than three decades as a substitute for the classical variance to characterize the stability of clocks or frequency standards when the underlying process is a 1/f noise process. However, its applications are related only to the noise models characterized by the power law of the spectral density. In this paper, from the viewpoint of the time domain, we provide a statistical underpinning of the Allan variance for discrete stationary processes, random walk and long-memory processes such as the fractional difference processes including the noise models usually considered in time and frequency metrology. Results show that the Allan variance is a better measure of the process variation than the classical variance of the random walk and the non-stationary fractional difference processes including the 1/f noise.

  7. Relationship between Allan variances and Kalman Filter parameters

    NASA Technical Reports Server (NTRS)

    Vandierendonck, A. J.; Mcgraw, J. B.; Brown, R. G.

    1984-01-01

    A relationship was constructed between the Allan variance parameters (H sub z, H sub 1, H sub 0, H sub -1 and H sub -2) and a Kalman Filter model that would be used to estimate and predict clock phase, frequency and frequency drift. To start with the meaning of those Allan Variance parameters and how they are arrived at for a given frequency source is reviewed. Although a subset of these parameters is arrived at by measuring phase as a function of time rather than as a spectral density, they all represent phase noise spectral density coefficients, though not necessarily that of a rational spectral density. The phase noise spectral density is then transformed into a time domain covariance model which can then be used to derive the Kalman Filter model parameters. Simulation results of that covariance model are presented and compared to clock uncertainties predicted by Allan variance parameters. A two state Kalman Filter model is then derived and the significance of each state is explained.

  8. SuperMacLang: Development of an Authoring System.

    ERIC Educational Resources Information Center

    Frommer, Judith; Foelsche, Otmar K. E.

    1999-01-01

    Describes the development of "SuperMacLang, the 1990s version of the MacLang authoring system. An analysis of various features of the program explains the ways in which certain aspects of collaboration and funding affected developer and programming decisions. (Author/VWL)

  9. SuperMacLang: Development of an Authoring System.

    ERIC Educational Resources Information Center

    Frommer, Judith; Foelsche, Otmar K. E.

    1999-01-01

    Describes the development of "SuperMacLang, the 1990s version of the MacLang authoring system. An analysis of various features of the program explains the ways in which certain aspects of collaboration and funding affected developer and programming decisions. (Author/VWL)

  10. PhoSim: Photon Simulator

    NASA Astrophysics Data System (ADS)

    Peterson, John R.; Jernigan, J. Garrett

    2013-07-01

    The Photon Simulator (PhoSim) is a set of fast photon Monte Carlo codes used to calculate the physics of the atmosphere, telescope, and detector by using modern numerical techniques applied to comprehensive physical models. PhoSim generates images by collecting photons into pixels. The code takes the description of what astronomical objects are in the sky at a particular time (the instance catalog) as well as the description of the observing configuration (the operational parameters) and produces a realistic data stream of images that are similar to what a real telescope would produce. PhoSim was developed for large aperture wide field optical telescopes, such as the planned design of LSST. The initial version of the simulator also targeted the LSST telescope and camera design, but the code has since been broadened to include existing telescopes of a related nature. The atmospheric model, in particular, includes physical approximations that are limited to this general context.

  11. QuakeSim Project Networking

    NASA Astrophysics Data System (ADS)

    Kong, D.; Donnellan, A.; Pierce, M. E.

    2012-12-01

    QuakeSim is an online computational framework focused on using remotely sensed geodetic imaging data to model and understand earthquakes. With the rise in online social networking over the last decade, many tools and concepts have been developed that are useful to research groups. In particular, QuakeSim is interested in the ability for researchers to post, share, and annotate files generated by modeling tools in order to facilitate collaboration. To accomplish this, features were added to the preexisting QuakeSim site that include single sign-on, automated saving of output from modeling tools, and a personal user space to manage sharing permissions on these saved files. These features implement OpenID and Lightweight Data Access Protocol (LDAP) technologies to manage files across several different servers, including a web server running Drupal and other servers hosting the computational tools themselves.

  12. ThêoH: a hybrid, high-confidence statistic that improves on the Allan deviation

    NASA Astrophysics Data System (ADS)

    Howe, D. A.

    2006-08-01

    'Theo1' (short terminology for 'theoretical variance #1') is derived based on \\psi_y^2(\\tau_s,\\tau) , a variance that separates the Allan variance's averaging time (τ) from its sampling interval (τs), also called 'stride', as applied to normalized fractional-frequency y(t). The τ-length average of y(t) is denoted {^\\tau}\\overline {y}(t) , and every permissible squared difference of {^\\tau}\\overline {y}(t) -values in \\psi_y^2(\\tau_s,\\tau) is averaged in mτ0 segments of y(t) to compute Theo1(m, τ0). Although biased relative to the Allan variance, Theo1(m, τ0) mimics all statistical properties of the Allan variance and works to very long stride. Its estimator \\widehat{Theo1}(\\tau_s) has substantially better confidence compared with the best Allan estimator \\hat\\sigma_y^2(\\tau_s) , called 'Avar'. To make an Allan-compatible statistic, a novel 'bias-removed' version of \\widehat{Theo1} variance, called ' \\widehat{TheoBR} ' variance, yields ThêoH variance ('H' to indicate high confidence and/or hybrid Allan and \\widehat{TheoBR} functions). ThêoH deviation combines the Allan deviation in short term and \\widehat{TheoBR} deviation in long term, reporting very long-term frequency stability 50% beyond that possible using the Allan deviation alone and with excellent confidence.

  13. Pragmatics: The State of the Art: An Online Interview with Keith Allan

    ERIC Educational Resources Information Center

    Allan, Keith; Salmani Nodoushan, Mohammad Ali

    2015-01-01

    This interview was conducted with Professor Keith Allan with the aim of providing a brief but informative summary of the state of the art of pragmatics. In providing answers to the interview questions, Professor Allan begins with a definition of pragmatics as it is practiced today, i.e., the study of the meanings of utterances with attention to…

  14. A Simple Algorithm for Approximating Confidence on the Modified Allan Variance and the Time Variance

    NASA Technical Reports Server (NTRS)

    Weiss, Marc A.; Greenhall, Charles A.

    1996-01-01

    An approximating algorithm for computing equvalent degrees of freedom of the Modified Allan Variance and its square root, the Modified Allan Deviation (MVAR and MDEV), and the Time Variance and Time Deviation (TVAR and TDEV) is presented, along with an algorithm for approximating the inverse chi-square distribution.

  15. A Simple Algorithm for Approximating Confidence on the Modified Allan Variance and the Time Variance

    NASA Technical Reports Server (NTRS)

    Weiss, Marc A.; Greenhall, Charles A.

    1996-01-01

    An approximating algorithm for computing equvalent degrees of freedom of the Modified Allan Variance and its square root, the Modified Allan Deviation (MVAR and MDEV), and the Time Variance and Time Deviation (TVAR and TDEV) is presented, along with an algorithm for approximating the inverse chi-square distribution.

  16. PRUNE—SIM users guide.

    Treesearch

    R.D. Fight; J.M. Cahill; T.A. Snellgrove; T.D. Fahey

    1987-01-01

    PRUNE-SIM is a spreadsheet template (program) that allows users to simulate a financial analysis of pruning coast Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii). The program estimates the increase in product value resulting from pruning the butt 17-foot log. Product recovery information is based on actual...

  17. Case Report: Atypical Cornelia de Lange Syndrome

    PubMed Central

    Leanza, Vito; Rubbino, Gabriella; Leanza, Gianluca

    2015-01-01

    Cornelia de Lange Syndrome (CdLS) (also called Bushy Syndrome or Amsterdam dwarfism), is a genetic disorder that can lead to several alterations. This disease affects both physical and neuropsychiatric development. The various abnormalities include facial dysmorphia (arched eyebrows, synophrys, depressed nasal bridge, long philtrum, down-turned angles of the mouth), upper-extremity malformations, hirsutism, cardiac defects, and gastrointestinal alterations. The prevalence of this syndrome is approximately one per 15,000. Ultrasound is not the perfect means to diagnose CdLS, however, many abnormalities can be detected prenatally by scrupulous image observation. We report an atypical CdLS case characterized by increased nuchal translucency in the first trimester, normal karyotype, saddle nose, micrognathia with receding jaw, low set ears, facies senilis, arthrogryposis of the hands, absence of the Aranzio ductus venous, dilatation of gallbladder and bowel, a unique umbilical artery, increased volume of amniotic fluid, and intrauterine growth retardation ending with the interruption of pregnancy. PMID:26834972

  18. The dynamic Allan Variance IV: characterization of atomic clock anomalies.

    PubMed

    Galleani, Lorenzo; Tavella, Patrizia

    2015-05-01

    The number of applications where precise clocks play a key role is steadily increasing, satellite navigation being the main example. Precise clock anomalies are hence critical events, and their characterization is a fundamental problem. When an anomaly occurs, the clock stability changes with time, and this variation can be characterized with the dynamic Allan variance (DAVAR). We obtain the DAVAR for a series of common clock anomalies, namely, a sinusoidal term, a phase jump, a frequency jump, and a sudden change in the clock noise variance. These anomalies are particularly common in space clocks. Our analytic results clarify how the clock stability changes during these anomalies.

  19. Astrometeric Science with SIM PlanetQuest

    NASA Technical Reports Server (NTRS)

    Shao, Michael; Unwin, Stephen

    2006-01-01

    This viewgraph presentation reviews Astrometry with the Space Interferometry Mission (SIM) PlanetQuest. The topics include: 1) SIM PlanetQuest - the World's First Long- Baseline Optical Interferometer in Space; 2) National Academy of Sciences / NRC endorses SIM PlanetQuest; 3) SIM Planet Search; 4) Planetary System Architectures & Diversity; 5) SIM Search for 110 M(sub Earth) Planets Around Nearby Stars; 6) Deep Search of 120 nearby stars; 7) Planets around Young Stars; 8) SIM PlanetQuest Science Team; 9) Dark Halo of our Galaxy; 10) Dynamics of Galaxy Groups within 5 Mpc; 11) Probing Active Galactic Nuclei with Astrometry; 12) Snapshot Observing Mode: Astrometry for the masses; 13) SIM Technology Development is Complete; and 14) SIM Hardware, Tested for Flight.

  20. Princess Marie Bonaparte, Edgar Allan Poe, and psychobiography.

    PubMed

    Warner, S L

    1991-01-01

    Princess Marie Bonaparte was a colorful yet mysterious member of Freud's inner circle of psychoanalysis. In analysis with Freud beginning in 1925 (she was then 45 years old), she became a lay analyst and writer of many papers and books. Her most ambitious task was a 700-page psychobiography of Edgar Allan Poe that was first published in French in 1933. She was fascinated by Poe's gothic stories--with the return to life of dead persons and the eerie, unexpected turns of events. Her fascination with Poe can be traced to the similarity of their early traumatic life experiences. Bonaparte had lost her mother a month after her birth. Poe's father deserted the family when Edgar was two years old, and his mother died of tuberculosis when he was three. Poe's stories helped him to accommodate to these early traumatic losses. Bonaparte vicariously shared in Poe's loss and the fantasies of the return of the deceased parent in his stories. She was sensitive and empathetic to Poe's inner world because her inner world was similar. The result of this psychological fit between Poe and Bonaparte was her psychobiography, The Life and Works of Edgar Allan Poe. It was a milestone in psychobiography but limited in its psychological scope by its strong emphasis on early childhood trauma. Nevertheless it proved Bonaparte a bona fide creative psychoanalyst and not a dilettante propped up by her friendship with Freud.

  1. Electrospray Droplet Impact/SIMS

    NASA Astrophysics Data System (ADS)

    Hiraoka, Kenzo

    A new type of cluster SIMS, named as electrospray droplet impact (EDI), has been developed in our laboratory. It was found that peptides deposited on the stainless steel substrate were ionized/desorbed without the accumulation of radiation products. The organic samples with film thickness thinner than 10 monolayers are desorbed/ionized with little damage underneath the surface. In general, rather strong negative ions as well as positive ions are generated. The mechanism for the ionization/desorption in EDI is much less complicated than those for MALDI and SIMS due to the fact that only very thin sample layers take part in the shock-wave excited selvedge and higher-order side reactions are largely suppressed.

  2. Genetics Home Reference: Jervell and Lange-Nielsen syndrome

    MedlinePlus

    ... KCNQ1 or KCNE1 mutation have a long QT interval with related heart abnormalities, but their hearing is ... disease Jervell-Lange Nielsen syndrome JLNS prolonged QT interval in EKG and sudden death surdo-cardiac syndrome ...

  3. Cornelia de Lange Syndrome: Evolution of the Phenotype

    ERIC Educational Resources Information Center

    Passarge, Eberhard; And Others

    1971-01-01

    The medical case history of a 2-year-old girl who developed, during the second year of life, the classical phenotype (typical appearance) indicative of the deLange syndrome, with both mental and physical impairment. (KW)

  4. Cornelia de Lange Syndrome: Evolution of the Phenotype

    ERIC Educational Resources Information Center

    Passarge, Eberhard; And Others

    1971-01-01

    The medical case history of a 2-year-old girl who developed, during the second year of life, the classical phenotype (typical appearance) indicative of the deLange syndrome, with both mental and physical impairment. (KW)

  5. 'On periodical depressions and their pathogenesis' by Carl Lange (1886).

    PubMed

    Schioldann, Johann

    2011-03-01

    Carl Lange was the founding father of neurology in Denmark, authoring several pioneering works within this field; however, these remained largely unknown internationally as he did not have them translated into a major language. He became a pioneer of psychophysiology with his contribution to the so-called James-Lange theory of emotion. His treatise on'periodical depressions' ('the Lange theory of depressions', 1886), is not only an early historical landmark but also a masterly 'modern' description concerning the nosology and nosography of recurrent depressions. Moreover, it is a landmark in the early history of lithium therapy, sadly ignored by Lange's contemporaries, but which little more than half a century later, with Cade's rediscovery of lithium's therapeutic effect in mood disorders in 1949, ushered in modern psychopharmacology.

  6. WEC-Sim (Wave Energy Converter - SIMulator)

    SciTech Connect

    2014-11-26

    WEC-Sim (Wave Energy Converter SIMulator) is a code developed by Sandia National Laboratories and the National Renewable Energy Laboratory to model wave energy converters (WECs) when they are subject to operational waves. The code is a time-domain modeling tool developed in MATLAB/Simulink using the multi-body dynamics solver SimMechanics. In WEC-Sim, WECs are modeled by connecting rigid bodies to one another with joint or constraint blocks from the WEC-Sim library. WEC-Sim is a publicly available, open-source code to model WECs.

  7. Safeguards Information Management Systems (SIMS)

    SciTech Connect

    Sorenson, R.J.; Sheely, K.B.; Brown, J.B.; Horton, R.D.; Strittmatter, R.; Manatt, D.R.

    1994-04-01

    The requirements for the management of information at the International Atomic Energy Agency (IAEA) and its Department of Safeguards are rapidly changing. Historically, the Department of Safeguards has had the requirement to process large volumes of conventional safeguards information. An information management system is currently in place that adequately handles the IAEA`s conventional safeguards data needs. In the post-Iraq environment, however, there is a growing need to expand the IAEA information management capability to include unconventional forms of information. These data include environmental sampling results, photographs, video film, lists of machine tools, and open-source materials such as unclassified publications. The US Department of Energy (DOE) has responded to this information management need by implementing the Safeguards Information Management Systems (SIMS) initiative. SIMS was created by the DOE to anticipate and respond to IAEA information management needs through a multilaboratory initiative that will utilize an integrated approach to develop and deploy technology in a timely and cost-effective manner. The DOE will use the SIMS initiative to coordinate US information management activities that support the IAEA Department of Safeguards.

  8. Ratio estimation in SIMS analysis

    NASA Astrophysics Data System (ADS)

    Ogliore, R. C.; Huss, G. R.; Nagashima, K.

    2011-09-01

    The determination of an isotope ratio by secondary ion mass spectrometry (SIMS) traditionally involves averaging a number of ratios collected over the course of a measurement. We show that this method leads to an additive positive bias in the expectation value of the estimated ratio that is approximately equal to the true ratio divided by the counts of the denominator isotope of an individual ratio. This bias does not decrease as the number of ratios used in the average increases. By summing all counts in the numerator isotope, then dividing by the sum of counts in the denominator isotope, the estimated ratio is less biased: the bias is approximately equal to the ratio divided by the summed counts of the denominator isotope over the entire measurement. We propose a third ratio estimator (Beale's estimator) that can be used when the bias from the summed counts is unacceptably large for the hypothesis being tested. We derive expressions for the variance of these ratio estimators as well as the conditions under which they are normally distributed. Finally, we investigate a SIMS dataset showing the effects of ratio bias, and discuss proper ratio estimation for SIMS analysis.

  9. GaAs monolithic Lange and Wilkinson couplers

    NASA Astrophysics Data System (ADS)

    Waterman, R. C., Jr.; Fabian, W.; Pucel, R. A.; Tajima, Y.; Vorhaus, J. L.

    1981-02-01

    A monolithic GaAs X-band three-port Wilkinson coupler and a monolithic GaAs X-band four-port interdigitated Lange coupler are examined with reference to their design, fabrication technology, and experimental performance data. It is shown that fabrication of these couplers is compatible with present MMIC technologies. Measured loss minus fixture contributions is 0.25 dB and 0.75 dB for the Wilkinson and the Lange couplers, respectively.

  10. SIM Lite Astrometric Observatory Progress Report

    NASA Technical Reports Server (NTRS)

    Marr, James C., IV; Shao, Michael; Goullioud, Renaud

    2010-01-01

    The SIM Lite Astrometric Observatory (aka SIM Lite), a micro-arcsecond astrometry space mission, has been developed in response to NASA's indefinite deferral of the SIM PlanetQuest mission. The SIM Lite mission, while significantly more affordable than the SIM PlanetQuest mission concept, still addresses the full breadth of SIM science envisioned by two previous National Research Council (NRC) Astrophysics Decadal Surveys at the most stringent 'Goal' level of astrometric measurement performance envisioned in those surveys. Over the past two years, the project has completed the conceptual design of the SIM Lite mission using only the completed SIM technology; published a 250 page book describing the science and mission design (available at the SIM website: http://sim.jpl.nasa.gov); been subject to an independent cost and technical readiness assessment by the Aerospace Corporation; and submitted a number of information responses to the NRC Astro2010 Decadal Survey. The project also conducted an exoplanet-finding capability double blind study that clearly demonstrated the ability of the mission to survey 60 to 100 nearby sun-like dwarf stars for terrestrial, habitable zone planets in complex planetary systems. Additionally, the project has continued Engineering Risk Reduction activities by building brassboard (form, fit and function to flight) version of key instrument elements and subjecting them to flight qualification environmental and performance testing. This paper summarizes the progress over the last two years and the current state of the SIM Lite project.

  11. SIM Lite Astrometric Observatory progress report

    NASA Astrophysics Data System (ADS)

    Marr, James C., IV; Shao, Michael; Goullioud, Renaud

    2010-07-01

    The SIM Lite Astrometric Observatory (aka SIM Lite), a micro-arcsecond astrometry space mission, has been developed in response to NASA's indefinite deferral of the SIM PlanetQuest mission. The SIM Lite mission, while significantly more affordable than the SIM PlanetQuest mission concept, still addresses the full breadth of SIM science envisioned by two previous National Research Council (NRC) Astrophysics Decadal Surveys at the most stringent "Goal" level of astrometric measurement performance envisioned in those surveys. Over the past two years, the project has completed the conceptual design of the SIM Lite mission using only the completed SIM technology; published a 250 page book describing the science and mission design (available at the SIM website: http://sim.jpl.nasa.gov); been subject to an independent cost and technical readiness assessment by the Aerospace Corporation; and submitted a number of information responses to the NRC Astro2010 Decadal Survey. The project also conducted an exoplanet-finding capability double blind study that clearly demonstrated the ability of the mission to survey 60 to 100 nearby sun-like dwarf stars for terrestrial, habitable zone planets in complex planetary systems. Additionally, the project has continued Engineering Risk Reduction activities by building brassboard (form, fit & function to flight) version of key instrument elements and subjecting them to flight qualification environmental and performance testing. This paper summarizes the progress over the last two years and the current state of the SIM Lite project.

  12. Sequencing Information Management System (SIMS). Final report

    SciTech Connect

    Fields, C.

    1996-02-15

    A feasibility study to develop a requirements analysis and functional specification for a data management system for large-scale DNA sequencing laboratories resulted in a functional specification for a Sequencing Information Management System (SIMS). This document reports the results of this feasibility study, and includes a functional specification for a SIMS relational schema. The SIMS is an integrated information management system that supports data acquisition, management, analysis, and distribution for DNA sequencing laboratories. The SIMS provides ad hoc query access to information on the sequencing process and its results, and partially automates the transfer of data between laboratory instruments, analysis programs, technical personnel, and managers. The SIMS user interfaces are designed for use by laboratory technicians, laboratory managers, and scientists. The SIMS is designed to run in a heterogeneous, multiplatform environment in a client/server mode. The SIMS communicates with external computational and data resources via the internet.

  13. Cornelia de Lange syndrome, cohesin, and beyond

    PubMed Central

    Liu, J; Krantz, ID

    2010-01-01

    Cornelia de Lange syndrome (CdLS) (OMIM #122470, #300590 and #610759) is a dominant genetic disorder with multiple organ system abnormalities which is classically characterized by typical facial features, growth and mental retardation, upper limb defects, hirsutism, gastrointestinal and other visceral system involvement. Mutations in three cohesin proteins, a key regulator of cohesin, NIPBL, and two structural components of the cohesin ring SMC1A and SMC3, etiologically account for about 65% of individuals with CdLS. Cohesin controls faithful chromosome segregation during the mitotic and meiotic cell cycles. Multiple proteins in the cohesin pathway are also involved in additional fundamental biological events such as double-strand DNA break repair and long-range regulation of transcription. Moreover, chromosome instability was recently associated with defective sister chromatid cohesion in several cancer studies, and an increasing number of human developmental disorders is being reported to result from disruption of this pathway. Here, we will discuss the human disorders caused by alterations of cohesin function (termed ‘cohesinopathies’), with an emphasis on the clinical manifestations of CdLS and mechanistic studies of the CdLS-related proteins. PMID:19793304

  14. Seeds of a Soldier: The True Story of Edgar Allan Poe - The Sergeant Major

    DTIC Science & Technology

    2003-01-01

    2003 2. REPORT TYPE 3. DATES COVERED 00-00-2003 to 00-00-2003 4. TITLE AND SUBTITLE Seeds of a Soldier. The true story of Edgar Allan Poe - the...Std Z39-18 Army Space Journal Fall 200360 By Michael L. Howard Seeds of a Soldier The true story of Edgar Allan Poe — the Sergeant Major...the Managing Editor via email to richard.burks@arspace.army.mil dgar Allan Poe wore U.S. Army sergeant major stripes. Using the name Edgar A. Perry

  15. Allan Deviation Plot as a Tool for Quartz-Enhanced Photoacoustic Sensors Noise Analysis.

    PubMed

    Giglio, Marilena; Patimisco, Pietro; Sampaolo, Angelo; Scamarcio, Gaetano; Tittel, Frank K; Spagnolo, Vincenzo

    2016-04-01

    We report here on the use of the Allan deviation plot to analyze the long-term stability of a quartz-enhanced photoacoustic (QEPAS) gas sensor. The Allan plot provides information about the optimum averaging time for the QEPAS signal and allows the prediction of its ultimate detection limit. The Allan deviation can also be used to determine the main sources of noise coming from the individual components of the sensor. Quartz tuning fork thermal noise dominates for integration times up to 275 s, whereas at longer averaging times, the main contribution to the sensor noise originates from laser power instabilities.

  16. Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants

    PubMed Central

    Goshu, Eleni; Jin, Hui; Fasnacht, Rachel; Sepenski, Mike; Michaud, Jacques L.; Fan, Chen-Ming

    2002-01-01

    The mouse genome contains two Sim genes, Sim1 and Sim2. They are presumed to be important for central nervous system (CNS) development because they are homologous to the Drosophila single-minded (sim) gene, mutations in which cause a complete loss of CNS midline cells. In the mammalian CNS, Sim2 and Sim1 are coexpressed in the paraventricular nucleus (PVN). While Sim1 is essential for the development of the PVN (J. L. Michaud, T. Rosenquist, N. R. May, and C.-M. Fan, Genes Dev. 12:3264-3275, 1998), we report here that Sim2 mutant has a normal PVN. Analyses of the Sim1 and Sim2 compound mutants did not reveal obvious genetic interaction between them in PVN histogenesis. However, Sim2 mutant mice die within 3 days of birth due to lung atelectasis and breathing failure. We attribute the diminished efficacy of lung inflation to the compromised structural components surrounding the pleural cavity, which include rib protrusions, abnormal intercostal muscle attachments, diaphragm hypoplasia, and pleural mesothelium tearing. Although each of these structures is minimally affected, we propose that their combined effects lead to the mechanical failure of lung inflation and death. Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity. PMID:12024028

  17. Boron Isotopes in Antigorite from the Guatemala Suture Zone Serpentinite Mélanges, Guatemala: Origin of the Serpentinite.

    NASA Astrophysics Data System (ADS)

    Martin, C.; Harlow, G. E.; Marschall, H.

    2014-12-01

    The Guatemala Suture Zone (GSZ) features two serpentinite mélanges straddling the Motagua Fault system. In both North and South Motagua Mélanges (NMM and SMM, respectively), blocks of high-pressure, low-temperature metabasites (e.g., eclogites) are embedded into a serpentinite matrix, together with vein-related rocks (e.g., jadeitites). The origin of serpentinite forming the matrix is still unclear. It is commonly believed to represent either the seafloor / oceanic mantle hydrated by infiltration of seawater or the forearc mantle wedge hydrated by fluid released during subduction. Nowadays, the few data available on serpentinites from Mariana forearc, abyssal peridotite or ophiolitic massifs show positive or slightly negative δ11B (-4.6 to +40‰), in support of the assumption of a shallow origin for the fluid. However, it has been suggested that serpentinites could form much deeper within a subduction channel (~ 30 km depth). In situ boron analyses on antigorite from serpentinites of the GSZ have been carried out by LA-MC-ICPMS and SIMS. Serpentine matrices have low to moderate B concentrations, between 2 and 15µg/g. They display somewhat negative isotopic values, with δ11B of -8.2 ± 2.8 and -11.9 ± 1.2‰ for samples from the NMM, and δ11B of -4.1 ± 3.0 and -11.1 ± 1.8‰ for a sample from the SMM. In addition, this sample contains a late antigorite vein showing a δ11B of -3.0 ± 3.5‰, and some veinlets with scattered values (δ11B ranging from -12.5 ± 0.9 to -6.4 ± 1.4‰). This first suite of measurements carried out directly on serpentinites from serpentinite mélanges displays very negative values, which do not overlap with previously published data. It indicates that the ultramafic precursors of the serpentine from the GSZ Serpentinite Mélanges were not hydrated by seawater, or by fluid released during the early stages of subduction. Rather, these negative values indicate that the fluid responsible for the hydration of ultramafic rocks likely

  18. Seizures in the life and works of Edgar Allan Poe.

    PubMed

    Bazil, C W

    1999-06-01

    Edgar Allan Poe, one of the most celebrated of American storytellers, lived through and wrote descriptions of episodic unconsciousness, confusion, and paranoia. These symptoms have been attributed to alcohol or drug abuse but also could represent complex partial seizures, prolonged postictal states, or postictal psychosis. Complex partial seizures were not well described in Poe's time, which could explain a misdiagnosis. Alternatively, he may have suffered from complex partial epilepsy that was complicated or caused by substance abuse. Even today, persons who have epilepsy are mistaken for substance abusers and occasionally are arrested during postictal confusional states. Poe was able to use creative genius and experiences from illness to create memorable tales and poignant poems.

  19. Petrogenetic relationship between Allan Hills 77005 and other achondrites

    NASA Technical Reports Server (NTRS)

    Mcsween, H. Y., Jr.; Taylor, L. A.; Stolper, E. M.; Muntean, R. A.; Okelley, G. D.; Eldridge, J. S.; Biswas, S.; Ngo, H. T.; Lipschutz, M. E.

    1979-01-01

    The paper presents chemical and petrologic data relating the Allan Hills (ALHA) 77005 achondrite from Antarctica and explores their petrogenetic relationship with the shergottites. Petrologic similarities with the latter in terms of mineralogy, oxidation state, inferred source region composition, and shock ages suggest a genetic relationship, also indicated by volatile to involatile element ratios and abundances of other trace elements. ALHA 77005 may be a cumulate crystallized from a liquid parental to materials from which the shergottites crystallized or a sample of peridotite from which shergottite parent liquids were derived. Chemical similarities with terrestrial ultramafic rocks suggest that it provides an additional sample of the only other solar system body with basalt source origins chemically similar to the upper earth mantle.

  20. Chemical characterization of a unique chondrite - Allan Hills 85085

    NASA Technical Reports Server (NTRS)

    Gosselin, David C.; Laul, J. C.

    1990-01-01

    Allan Hills 85085 is a new and very important addition to the growing list of unique carbonaceous chondrites because of its unique chemical and mineralogical properties. This chemical study provides more precise data on the major, minor, and trace element characteristics of ALH85085. ALH85085 has compositional, petrological, and isotopic affinities to AL Rais and Renazzo, and to Bencubbin-Weatherford. The similarities to Al Rais and Renazzo suggest similar formation locations and thermal processing, possibly in the vicinity of CI chondrites. Petrologic, compositional and isotopic studies indicate that the components that control the abundance of the various refractory and volatile elements were not allowed to equilibrate with the nebula as conditions changed, explaining the inconsistencies in the classification of these meteorites using known taxonomic parameters.

  1. A new kind of primitive chondrite, Allan Hills 85085

    NASA Technical Reports Server (NTRS)

    Scott, Edward R. D.

    1988-01-01

    Allan Hills (ALH) 85085, a chemically and mineralogically unique chondrite whose components have suffered little metamorphism or alteration, is discussed. It is found that ALH 85085 has 4 wt pct chondrules (mean diameter 16 microns), 36 wt pct Fe, Ni, 56 wt pct lithic and mineral silicate fragments, and 2 wt pct trolite. It is suggested that, with the exception of matrix lumps, the components of ALH 85085 formed and accreted in the solar nebula. It is shown that ALH 85085 does not belong to any of the nine chondrite groups and is very different from Kakangari. Similarities between ALH 85085 and Bencubbin and Weatherford suggest that the latter two primitive meteorites may be chondrites with high metal abundances and very large, partly fragmented chondrules.

  2. The SIM Lite Astrometric Observatory

    NASA Astrophysics Data System (ADS)

    Unwin, Stephen C.

    2009-05-01

    SIM Lite is an observatory mission dedicated to precision astrometry. With a single measurement accuracy of 1 microarcsecond (µas) and a noise floor below 0.035 µas it will have the capability to do an extensive search for Earth-mass planets in the `habitable zone’ around several dozen of the nearest stars. SIM Lite maintains its wide-angle accuracy of 4 µas for all targets down to V = 19, limited only by observing time. This opens up a wide array of astrophysical problems. As a flexibly pointed instrument, it is a natural complement to sky surveys such as JMAPS and Gaia, and will tackle questions that don't require the acquisition of statistics on a large number of targets. It will provide accurate masses for the first time for a variety of exotic star types, including X-ray binaries; it will study the structure and evolution of our Galaxy through tidal streams from dwarf spheroidals and the trajectories of halo stars and galaxies. Its faint-target capability will enable the use of astrometric and photometric variability as a probe of the disk accretion and jet formation processes in blazars. SIM Lite will have an extensive GO (General Observer) program, open to all categories of astrometric science. The project successfully completed a series of technology milestones in 2005, and is currently under study by by NASA as a flight mission. The research described in this talk was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

  3. ViscoSim Earthquake Simulator

    USGS Publications Warehouse

    Pollitz, Fred

    2012-01-01

    Synthetic seismicity simulations have been explored by the Southern California Earthquake Center (SCEC) Earthquake Simulators Group in order to guide long‐term forecasting efforts related to the Unified California Earthquake Rupture Forecast (Tullis et al., 2012a). In this study I describe the viscoelastic earthquake simulator (ViscoSim) of Pollitz, 2009. Recapitulating to a large extent material previously presented by Pollitz (2009, 2011) I describe its implementation of synthetic ruptures and how it differs from other simulators being used by the group.

  4. TurbSim User's Guide

    SciTech Connect

    Jonkman, B. J.; Buhl, M. L., Jr.

    2005-09-01

    The TurbSim stochastic inflow turbulence code was developed to provide a numerical simulation of a full-field flow that contains coherent turbulence structures that reflect the proper spatiotemporal turbulent velocity field relationships seen in instabilities associated with nocturnal boundary layer flows that are not represented well by the IEC Normal Turbulence Models (NTM). Its purpose is to provide the wind turbine designer with the ability to drive design code (FAST or MSC.ADAMS) simulations of advanced turbine designs with simulated inflow turbulence environments that incorporate many of the important fluid dynamic features known to adversely affect turbine aeroelastic response and loading.

  5. The History of Allan Hills 84001 Revised: Multiple Shock Events

    NASA Technical Reports Server (NTRS)

    Treiman, Allan H.

    1998-01-01

    The geologic history of Martian meteorite Allan Hills (ALH) 84001 is more complex than previously recognized, with evidence for four or five crater-forming impacts onto Mars. This history of repeated deformation and shock metamorphism appears to weaken some arguments that have been offered for and against the hypothesis of ancient Martian life in ALH 84001. Allan Hills 84001 formed originally from basaltic magma. Its first impact event (I1) is inferred from the deformation (D1) that produced the granular-textured bands ("crush zones") that transect the original igneous fabric. Deformation D1 is characterized by intense shear and may represent excavation or rebound flow of rock beneath a large impact crater. An intense thermal metamorphism followed D1 and may be related to it. The next impact (I2) produced fractures, (Fr2) in which carbonate "pancakes" were deposited and produced feldspathic glass from some of the igneous feldspars and silica. After I2, carbonate pancakes and globules were deposited in Fr2 fractures and replaced feldspathic glass and possibly crystalline silicates. Next, feldspars, feldspathic glass, and possibly some carbonates were mobilized and melted in the third impact (I3). Microfaulting, intense fracturing, and shear are also associated with 13. In the fourth impact (I4), the rock was fractured and deformed without significant heating, which permitted remnant magnetization directions to vary across fracture surfaces. Finally, ALH 84001 was ejected from Mars in event I5, which could be identical to I4. This history of multiple impacts is consistent with the photogeology of the Martian highlands and may help resolve some apparent contradictions among recent results on ALH 84001. For example, the submicron rounded magnetite grains in the carbonate globules could be contemporaneous with carbonate deposition, whereas the elongate magnetite grains, epitaxial on carbonates, could be ascribed to vapor-phase deposition during I3.

  6. The history of Allan Hills 84001 revised: multiple shock events.

    PubMed

    Treiman, A H

    1998-07-01

    The geologic history of Martian meteorite Allan Hills (ALH) 84001 is more complex than previously recognized, with evidence for four or five crater-forming impacts onto Mars. This history of repeated deformation and shock metamorphism appears to weaken some arguments that have been offered for and against the hypothesis of ancient Martian life in ALH 84001. Allan Hills 84001 formed originally from basaltic magma. Its first impact event (I1) is inferred from the deformation (D1) that produced the granular-textured bands ("crush zones") that transect the original igneous fabric. Deformation D1 is characterized by intense shear and may represent excavation or rebound flow of rock beneath a large impact crater. An intense thermal metamorphism followed D1 and may be related to it. The next impact (I2) produced fractures, (Fr2) in which carbonate "pancakes" were deposited and produced feldspathic glass from some of the igneous feldspars and silica. After I2, carbonate pancakes and globules were deposited in Fr2 fractures and replaced feldspathic glass and possibly crystalline silicates. Next, feldspars, feldspathic glass, and possibly some carbonates were mobilized and melted in the third impact (I3). Microfaulting, intense fracturing, and shear are also associated with I3. In the fourth impact (I4), the rock was fractured and deformed without significant heating, which permitted remnant magnetization directions to vary across fracture surfaces. Finally, ALH 84001 was ejected from Mars in event I5, which could be identical to I4. This history of multiple impacts is consistent with the photogeology of the Martian highlands and may help resolve some apparent contradictions among recent results on ALH 84001. For example, the submicron rounded magnetite grains in the carbonate globules could be contemporaneous with carbonate deposition, whereas the elongate magnetite grains, epitaxial on carbonates, could be ascribed to vapor-phase deposition during I3.

  7. The History of Allan Hills 84001 Revised: Multiple Shock Events

    NASA Technical Reports Server (NTRS)

    Treiman, Allan H.

    1998-01-01

    The geologic history of Martian meteorite Allan Hills (ALH) 84001 is more complex than previously recognized, with evidence for four or five crater-forming impacts onto Mars. This history of repeated deformation and shock metamorphism appears to weaken some arguments that have been offered for and against the hypothesis of ancient Martian life in ALH 84001. Allan Hills 84001 formed originally from basaltic magma. Its first impact event (I1) is inferred from the deformation (D1) that produced the granular-textured bands ("crush zones") that transect the original igneous fabric. Deformation D1 is characterized by intense shear and may represent excavation or rebound flow of rock beneath a large impact crater. An intense thermal metamorphism followed D1 and may be related to it. The next impact (I2) produced fractures, (Fr2) in which carbonate "pancakes" were deposited and produced feldspathic glass from some of the igneous feldspars and silica. After I2, carbonate pancakes and globules were deposited in Fr2 fractures and replaced feldspathic glass and possibly crystalline silicates. Next, feldspars, feldspathic glass, and possibly some carbonates were mobilized and melted in the third impact (I3). Microfaulting, intense fracturing, and shear are also associated with 13. In the fourth impact (I4), the rock was fractured and deformed without significant heating, which permitted remnant magnetization directions to vary across fracture surfaces. Finally, ALH 84001 was ejected from Mars in event I5, which could be identical to I4. This history of multiple impacts is consistent with the photogeology of the Martian highlands and may help resolve some apparent contradictions among recent results on ALH 84001. For example, the submicron rounded magnetite grains in the carbonate globules could be contemporaneous with carbonate deposition, whereas the elongate magnetite grains, epitaxial on carbonates, could be ascribed to vapor-phase deposition during I3.

  8. Sleep disorders in Cornelia de Lange syndrome.

    PubMed

    Zambrelli, Elena; Fossati, Chiara; Turner, Katherine; Taiana, Matteo; Vignoli, Aglaia; Gervasini, Cristina; Russo, Silvia; Furia, Francesca; Masciadri, Maura; Ajmone, Paola; Kullman, Gaia; Canevini, Maria Paola; Selicorni, Angelo

    2016-06-01

    Cornelia de Lange syndrome (CdLS) is a rare genetic disorder characterized by growth retardation, intellectual disability, limb defects, typical facial dysmorphism, and other systemic involvement. Sleep disturbances have been frequently reported in CdLS, but these have not been completely characterized, and prevalence data are conflicting. The aim of this paper is to characterize and determine the prevalence of sleep disorders in CdLS patients by means of a validated questionnaire. From November 2012 to November 2013, we asked 46 consecutive parents/caregivers of CdLS patients aged more than 3 years old to fill out the sleep disturbances scale for children (SDSC). The subjects were also characterized by the presence of epilepsy, intellectual disability (ID), behavioral problems, CdLS severity score, gastroesophageal reflux disease (GERD), and genetic test results. An abnormal total sleep score was found in 7 patients (15.2%), 26 (56.5%) showed a borderline total score, and 18 (39.1%) had an abnormal score for at least one SDSC factor. In our study sleep disorders were found to be positively associated to presence of epilepsy, GERD, ID, and behavioral disturbances. No correlation was evident with specific mutations of the different genes, BMI, and severity score. Our results confirm that sleep disorders represent a common problem in CdLS, with higher incidence than in the normal population. In these patients sleep disorders seem to be more prevalent in comorbid settings, representing a clinical indicator for different medical and neuropsychiatric disorders. Better knowledge and characterization of typology of sleep disorders in CdLS patients could permit a more specific therapeutic approach. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. Immunologic features of Cornelia de Lange syndrome.

    PubMed

    Jyonouchi, Soma; Orange, Jordan; Sullivan, Kathleen E; Krantz, Ian; Deardorff, Matthew

    2013-08-01

    Cornelia de Lange syndrome (CdLS) is a genetic syndrome with multisystem abnormalities. Infections are a significant cause of morbidity and mortality. The goals of our study were to identify the frequency and types of infections in CdLS and to determine if underlying immunodeficiency contributes to the clinical spectrum of this syndrome. We assessed infectious histories in 45 patients with CdLS and evaluated conventional immunologic screening tests in 27 patients. Among these 27 subjects, additional phenotypic enumeration of T-cell subsets, expression of activation markers in T cells, and production of cytokines in response to T-cell stimulants were studied in 12 CdLS subjects compared with 12 normal case control subjects. Recurrent infections were reported at high frequency in CdLS patients and included chronic ear infections (53%), chronic viral respiratory infections (46%), pneumonia (42%), sinus infections (33%), oral candidiasis (13%), sepsis (6%), and bacterial skin infections (4%). Full immune evaluation in 27 subjects led to identification of 9 cases of antibody deficiency syndrome in patients with severe forms of CdLS. Subjects with CdLS had decreased percentages of T regulatory cells and T follicular helper cells compared with normal control subjects (P < .05). This study identified for the first time a high frequency of antibody deficiency in CdLS subjects, indicating a critical need for screening and management of immunodeficiency in CdLS patients with a history of well-documented severe or recurrent infections. Furthermore, our results indicate that impaired T-cell populations may be associated with antibody deficiency in CdLS.

  10. Exploring Thermal Signatures in the Experimentally Heated CM Carbonaceous Chondrite Allan Hills 83100

    NASA Astrophysics Data System (ADS)

    Lindgren, P.; Andreassen, A. M.; Lee, M. R.; Sparkes, R.; Greenwood, R. C.; Franchi, I. A.

    2016-08-01

    We have examined the effect of experimental heating on water/hydroxyl content, carbon structure, O-isotope signature, and sulphide and carbonate microstructure in the highly aqueously altered meteorite Allan Hills 83100.

  11. The SIM PlanetQuest Science Program

    NASA Technical Reports Server (NTRS)

    Edberg, Stephen J.; Traub, Wesley A.; Unwin, Stephen C.; Marr, James C., IV

    2007-01-01

    SIM PlanetQuest (hereafter, just SIM) is a NASA mission to measure the angular positions of stars with unprecedented accuracy. We outline the main astrophysical science programs planned for SIM, and related opportunities for community participation. We focus especially on SIM's ability to detect exoplanets as small as the Earth around nearby stars. The planned synergy between SIM and other planet-finding missions including Kepler and GAIA, and planet-characterizing missions including the James Webb Space Telescope (JWST), Terrestrial Planet Finder--Coronagraph (TPF-C), and Terrestrial Planet Finder--Interferometer (TPF-I), is a key element in NASA's Navigator Program to find Earth-like planets, determine their habitability, and search for signs of life in the universe. SIM's technology development is now complete and the project is proceeding towards a launch in the next decade.

  12. The SIM PlanetQuest Science Program

    NASA Technical Reports Server (NTRS)

    Edberg, Stephen J.; Traub, Wesley A.; Unwin, Stephen C.; Marr, James C., IV

    2007-01-01

    SIM PlanetQuest (hereafter, just SIM) is a NASA mission to measure the angular positions of stars with unprecedented accuracy. We outline the main astrophysical science programs planned for SIM, and related opportunities for community participation. We focus especially on SIM's ability to detect exoplanets as small as the Earth around nearby stars. The planned synergy between SIM and other planet-finding missions including Kepler and GAIA, and planet-characterizing missions including the James Webb Space Telescope (JWST), Terrestrial Planet Finder--Coronagraph (TPF-C), and Terrestrial Planet Finder--Interferometer (TPF-I), is a key element in NASA's Navigator Program to find Earth-like planets, determine their habitability, and search for signs of life in the universe. SIM's technology development is now complete and the project is proceeding towards a launch in the next decade.

  13. Discovery of Planetary Systems With SIM

    DTIC Science & Technology

    2008-01-01

    planetary systems. In the past five years, over 70 extrasolar planets have been discovered by precision Doppler surveys, most by members of this SIM team...We are using the data base of information gleaned from our Doppler survey to choose the best targets for a new SIM planet search. In the same way that...our Doppler database now serves SIM, our team will return a recon- naissance database to focus Terresrial Planet Finder (TPF) into a more productive

  14. Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss.

    PubMed

    Gagliardi, Lucia; Nataren, Nathalie; Feng, Jinghua; Schreiber, Andreas W; Hahn, Christopher N; Conwell, Louise S; Coman, David; Scott, Hamish S

    2015-08-01

    The Allan-Herndon-Dudley syndrome is caused by mutations in the thyroid hormone transporter, Monocarboxylate transporter 8 (MCT8). It is characterized by profound intellectual disability and abnormal thyroid function. We report on a patient with Allan-Herndon-Dudley syndrome (AHDS) with profound sensorineural hearing loss which is not usually a feature of AHDS and which may have been due to a coexisting nonsense mutation in Microphthalmia-associated transcription factor (MITF).

  15. On the application of Allan variance method for Ring Laser Gyro performance characterization

    SciTech Connect

    Ng, L.C.

    1993-10-15

    This report describes the method of Allan variance and its application to the characterization of a Ring Laser Gyro`s (RLG) performance. Allan variance, a time domain analysis technique, is an accepted IEEE standard for gyro specifications. The method was initially developed by David Allan of the National Bureau of Standards to quantify the error statistics of a Cesium beam frequency standard employed as the US Frequency Standards in 1960`s. The method can, in general, be applied to analyze the error characteristics of any precision measurement instrument. The key attribute of the method is that it allows for a finer, easier characterization and identification of error sources and their contribution to the overall noise statistics. This report presents an overview of the method, explains the relationship between Allan variance and power spectral density distribution of underlying noise sources, describes the batch and recursive implementation approaches, validates the Allan variance computation with a simulation model, and illustrates the Allan variance method using data collected from several Honeywell LIMU units.

  16. Kaj Ulrik Linderstrøm-Lang (1896-1959).

    PubMed Central

    Schellman, J. A.; Schellman, C. G.

    1997-01-01

    The Carlsberg Laboratory in Copenhagen has had a long tradition of outstanding science. At the time covered by this discussion, Kjeldahl, Sørensen, and Linderstrøm-Lang had been consecutive directors of the Chemical Laboratory for 83 years. Lang's inspired leadership began in the 1930s with a number of innovations (study of metabolism in single cells, titrations in non-aqueous solvents, relation of proteolysis to structure) but it was not until the early 1950s that Denmark had sufficiently recovered from the war for the laboratory to enter world science again. During World War II, Lang had been active in the Danish resistance movement. After the war, a number of major advances were being made that would revolutionize the field of protein chemistry (Pauling and Corey's H-bonded structures, Sanger's sequencing techniques, chromatography, Watson and Crick structures, modern instrumentation). The time for the new field of the physical biochemistry of proteins had arrived. Lang, with his broad experience, adventurous spirit, and genius for innovation, created an environment that was ideal for the convergence of these disconnected advances into a uniform science. The emphasis was to be on quantitative measurements on proteins in solution with interpretations based on molecular structures. During an all-too-brief period of time, Lang's laboratory attracted a large fraction of those who were destined to be the leaders of the next generation of protein chemists. At this time, the Carlsberg Laboratory was probably the most scientifically exciting environment for a protein chemist. The methods developed at that time-hydrogen exchange, limited proteolysis, optical rotatory dispersion, volume changes accompanying protein reactions, automatic titrations-are still all in common use and many of the visitors to the laboratory in that period and their students are still playing major roles in protein research. Lang's other qualities should not be ignored. He was not only a great

  17. AXAF SIM focus mechanism study

    NASA Astrophysics Data System (ADS)

    Tananbaum, H. D.; Whitbeck, E.

    1994-02-01

    The design requirements and initial design concept for the AXAF-I Science Instrument Module (SIM) were reviewed at Ball on September 29, 1993. The concept design SIM focus mechanism utilizes a planetary gearset, with redundant motors, to drive a large ring (called 'main housing bearing') via a spur gearset. This large drive ring actuates three tangent bar links (called 'push rods'), which in turn actuate three levers (called 'pin levers'). Each of the three pin levers rotates an 'eccentric pin,' which in turn moves the base of a bipod flexure in both the radial (normal to optical axis) and axial (focus along optical axis) directions. Three bipod flexures are employed, equally spaced at 120 degrees apart, the base of each being translated in the two directions as described above. A focus adjustment is made by rotating the drive ring, which drives the push rods and therefore the pin levers, which in turn rotate the eccentric pins, finally imparting the two motions to the base of each of the bipod flexures. The axial translation (focus adjustment) of the focused structure is the sum of the direct axial motion plus axial motion which comes from uniformly squeezing the three bipod bases radially inward. SAO documented the following concerns regarding the focus mechanism in memo WAP-FY94-001, dated October 7, 1993: (1) The focus adjustment depends, in large part, on the structural properties (stiffnesses and end fixities) of the bipod flexures, push rods, pin levers and eccentric pins. If these properties are not matched very well, then lateral translations as well as unwanted rotations of the focussed structure will accompany focus motion. In addition, the stackup of linkage tolerances and any nonuniform wear in the linkages will result in the same unwanted motions. Thermal gradients will also affect these motions. At the review Ball did not present supporting analyses to support their choice of this design concept. (2) The proposed 'primary' method of measuring focus

  18. AXAF SIM focus mechanism study

    NASA Technical Reports Server (NTRS)

    Tananbaum, H. D.; Whitbeck, E.

    1994-01-01

    The design requirements and initial design concept for the AXAF-I Science Instrument Module (SIM) were reviewed at Ball on September 29, 1993. The concept design SIM focus mechanism utilizes a planetary gearset, with redundant motors, to drive a large ring (called 'main housing bearing') via a spur gearset. This large drive ring actuates three tangent bar links (called 'push rods'), which in turn actuate three levers (called 'pin levers'). Each of the three pin levers rotates an 'eccentric pin,' which in turn moves the base of a bipod flexure in both the radial (normal to optical axis) and axial (focus along optical axis) directions. Three bipod flexures are employed, equally spaced at 120 degrees apart, the base of each being translated in the two directions as described above. A focus adjustment is made by rotating the drive ring, which drives the push rods and therefore the pin levers, which in turn rotate the eccentric pins, finally imparting the two motions to the base of each of the bipod flexures. The axial translation (focus adjustment) of the focused structure is the sum of the direct axial motion plus axial motion which comes from uniformly squeezing the three bipod bases radially inward. SAO documented the following concerns regarding the focus mechanism in memo WAP-FY94-001, dated October 7, 1993: (1) The focus adjustment depends, in large part, on the structural properties (stiffnesses and end fixities) of the bipod flexures, push rods, pin levers and eccentric pins. If these properties are not matched very well, then lateral translations as well as unwanted rotations of the focussed structure will accompany focus motion. In addition, the stackup of linkage tolerances and any nonuniform wear in the linkages will result in the same unwanted motions. Thermal gradients will also affect these motions. At the review Ball did not present supporting analyses to support their choice of this design concept. (2) The proposed 'primary' method of measuring focus

  19. Modeling wildlife populations with HexSim

    EPA Science Inventory

    HexSim is a framework for constructing spatially-explicit, individual-based computer models designed for simulating terrestrial wildlife population dynamics and interactions. HexSim is useful for a broad set of modeling applications including population viability analysis for on...

  20. Prospects for Planet Detection with SIM

    NASA Astrophysics Data System (ADS)

    Catanzarite, Joseph; Law, N.; Shao, M.; Unwin, S.; Edberg, S.

    2007-07-01

    SIM is an optical Michelson interferometer with a 9-meter baseline, with angular precision of 1 microarcsecond in a single measurement. SIM's direct measurement of the stellar astrometric reflex motion due to a planetary companion permits accurate orbit determination, giving eccentricity and inclination, and most importantly, unambiguous measurement of the planet mass. SIM is the only mission that is * Sensitive to detection of planets across nearly the entire range of masses and orbit periods where terrestrial planets form and evolve. * Capable of detecting and confirming rocky planets in the habitable zones of nearby solar-type stars We present results of simulations quantifying SIM's planet detection sensitivity. We find that if each of the 64 most suitable target stars had an Earth-mass planet orbiting at the middle of its habitable zone, SIM would detect every one of them. We estimate SIM's planet yield for reasonable assumptions about the occurrence frequency and mass and period distribution of planets orbiting solar-type stars. For a "broad survey" of 2100 Hipparcos stars within 30 pc, we find that SIM would detect over 400 planets, including over 80 in the terrestrial mass range. By surveying thousands of stars comprising a broad range of stellar types, SIM will collect a large sample of planets down to the terrestrial mass range throughout the circumstellar domain where planets form and evolve. This will make possible the first detailed and comprehensive tests of planet formation theories.

  1. Modeling wildlife populations with HexSim

    EPA Science Inventory

    HexSim is a framework for constructing spatially-explicit, individual-based computer models designed for simulating terrestrial wildlife population dynamics and interactions. HexSim is useful for a broad set of modeling applications including population viability analysis for on...

  2. Secondary Ion Mass Spectrometry SIMS XI

    NASA Astrophysics Data System (ADS)

    Gillen, G.; Lareau, R.; Bennett, J.; Stevie, F.

    2003-05-01

    This volume contains 252 contributions presented as plenary, invited and contributed poster and oral presentations at the 11th International Conference on Secondary Ion Mass Spectrometry (SIMS XI) held at the Hilton Hotel, Walt Disney World Village, Orlando, Florida, 7 12 September, 1997. The book covers a diverse range of research, reflecting the rapid growth in advanced semiconductor characterization, ultra shallow depth profiling, TOF-SIMS and the new areas in which SIMS techniques are being used, for example in biological sciences and organic surface characterization. Papers are presented under the following categories: Isotopic SIMS Biological SIMS Semiconductor Characterization Techniques and Applications Ultra Shallow Depth Profiling Depth Profiling Fundamental/Modelling and Diffusion Sputter-Induced Topography Fundamentals of Molecular Desorption Organic Materials Practical TOF-SIMS Polyatomic Primary Ions Materials/Surface Analysis Postionization Instrumentation Geological SIMS Imaging Fundamentals of Sputtering Ion Formation and Cluster Formation Quantitative Analysis Environmental/Particle Characterization Related Techniques These proceedings provide an invaluable source of reference for both newcomers to the field and experienced SIMS users.

  3. simSchool: The Game of Teaching

    ERIC Educational Resources Information Center

    Zibit, Melanie; Gibson, David

    2005-01-01

    "simSchool" is a classroom simulation program funded by the Preparing Tomorrow's Teachers to Teach with Technology (PT3) program of the U.S. Department of Education. Just as a flight-simulator immerses a player in the complexities of flying a plane, "simSchool" immerses novice teachers in some of the complexities of teaching 7th-12th grade…

  4. Radial forcing and Edgar Allan Poe's lengthening pendulum

    NASA Astrophysics Data System (ADS)

    McMillan, Matthew; Blasing, David; Whitney, Heather M.

    2013-09-01

    Inspired by Edgar Allan Poe's The Pit and the Pendulum, we investigate a radially driven, lengthening pendulum. We first show that increasing the length of an undriven pendulum at a uniform rate does not amplify the oscillations in a manner consistent with the behavior of the scythe in Poe's story. We discuss parametric amplification and the transfer of energy (through the parameter of the pendulum's length) to the oscillating part of the system. In this manner, radial driving can easily and intuitively be understood, and the fundamental concept applied in many other areas. We propose and show by a numerical model that appropriately timed radial forcing can increase the oscillation amplitude in a manner consistent with Poe's story. Our analysis contributes a computational exploration of the complex harmonic motion that can result from radially driving a pendulum and sheds light on a mechanism by which oscillations can be amplified parametrically. These insights should prove especially valuable in the undergraduate physics classroom, where investigations into pendulums and oscillations are commonplace.

  5. Allan V. Cox: AGU President 1978”1980

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    When Allan V. Cox was presented AGU's John Adam Fleming Medal in 1969, John Verhoogen described Cox's work as “characterized by painstaking care, proper attention to and use of statistics, and great insight.” Those same thoughts were echoed on February 3, 1987, during the memorial service for Cox, who died in a bicycling accident on January 27. The Stanford Memorial Church was crowded with colleagues, students, and friends.The Fleming Medal was presented to Cox in recognition of his studies on the fluctuation of the geomagnetic field. These studies helped to confirm theories of continental drift and seafloor spreading. The medal is awarded annually by AGU for original research and technical leadership in geomagnetism, atmospheric electricity, aeronomy, and related sciences. In addition to the Fleming Medal, Cox received the Antarctic Service Medal in 1970, the Vetlesen Prize in 1971, and the Arthur L. Day Prize of the National Academy of Sciences in 1984. He was a Fellow of AGU and a member of the National Academy of Sciences.

  6. Classification of the Allan Hills A77307 meteorite

    NASA Technical Reports Server (NTRS)

    Sears, D. W. G.; Ross, M.

    1983-01-01

    Thermoluminescence (TL) measurements on Allan Hills A77307 (AH), a carbonaceous chondrite found in Antarctica, are compared with those on other chondrite and applied to its classification. Two lithologically different 250-mg samples were ground, freed of magnetic material, and ground again to pass a 100-micron sieve. Aliquots of 4 mg were heated to 500 C, exposed to beta radiation from a Sr-90 source, and heated at a rate of 7.3 C/sec in N2. TL was measured with a photomultiplier tube fitted with thermal and blue filters. Glow curves for AH and for seven other, established CO-type chondrites area presented, all exhibiting two major peaks of TL sensitivity. The peaks for the seven CO-type chondrites are found at 91 + or - 7 C and at 203 + or - 11 C; those for AH at 170 + or - 17 C and at approximately 250 C. This difference is considered significant and not due to random fluctuation or a typical sampling. From this comparison and from consideration of the weathering, preterrestrial-alteration, petrological and compositional evidence on AH, it is concluded that AH is a unique chondrite, possessing both similarities to and differences from the CO class.

  7. Listening, Looking, and Learning with MacLang.

    ERIC Educational Resources Information Center

    Frommer, Judith

    1989-01-01

    Describes how the capabilities of the MacLang authoring system allow foreign language teachers to develop computer-assisted instruction that meets the listening skill objectives of foreign language courses. Examples are given of the use of audio and video interfaces that facilitate listening comprehension. (Author/CB)

  8. Jervell and Lange-Nielsen Syndrome (Long QT Syndrome).

    ERIC Educational Resources Information Center

    Hulbert, T. P.

    1994-01-01

    Clinical features, pathogenetic hypotheses, and symptoms of the cardio-auditory or surdo-cardiac disorder first reported by Jervell and Lange-Nielsen are described, and methods of diagnosis and treatment are presented, to alert teachers and other professionals to potentially life-threatening symptoms they may observe when working with deaf and…

  9. [Auditory function in children with Brachmann-de Lange syndrom].

    PubMed

    Kozłowski, Jacek; Wierzba, Jolanta; Narozny, Waldemar; Balcerska, Anna; Stankiewicz, Czesław; Kuczkowski, Jerzy

    2006-01-01

    The aim of the research work is the evaluation of auditory function in children with rare, genetically determined Brachmann-de Lange syndrome. Test material came from 18 children (7 girls and 11 boys) between 11 months and 18 years of age with Brachmann-de Lange syndrome who have been diagnosed and treated at ENT Department and Department of Paediatrics, Haematology, Oncology and Endocrinology Medical University of Gdansk with support of Cornelia de Lange Association - Poland. In all children examinations of brainstem auditory evoked potential have been carried out as well as tympanometric examination in case of finding hearing loss. All these examinations were carried out in ENT Department of Medical University of Gdansk, using Racia-Alvar Centor C apparatus and Madsen-Zodiak 901. 9 (50%) of patients demonstrated hearing loss. In 3 (16.7%) cases the conduction hearing loss was connected with the chronic diseases of middle ear which required medical treatment. In remaining 6 (33.3%) cases due to sensorineural hearing loss children had hearing aids applied and underwent rehabilitation. The results indicate that all children with Brachmann-de Lange syndrome should undergo examinations of brainstem auditory evoked potential. It enables to detect hypoacusis and initiate proper treatment. Lack of the opportunity of having a hearing aid applied and further rehabilitation deepens the social isolation of the little patients and inhibits their natural progress in communication. In such cases mental retardation may subsequently occur.

  10. Language Acquisition in a Child with Cornelia De Lange Syndrome.

    ERIC Educational Resources Information Center

    Goodban, Marjorie T.

    The paper describes a successful attempt to stimulate expressive language in Becky, a young child with Cornelia de Lange syndrome, a condition characterized by moderate to severe mental retardation, dwarfed stature, and excessive body hair. The child participated in infant stimulation and individual speech therapy and her expressive output has…

  11. Characteristics of Autism Spectrum Disorder in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Moss, Jo; Howlin, Patricia; Magiati, Iliana; Oliver, Chris

    2012-01-01

    Background: The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in Cornelia de Lange syndrome (CdLS). However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. In this study we examine the ASD profile in CdLS in…

  12. Jervell and Lange-Nielsen Syndrome (Long QT Syndrome).

    ERIC Educational Resources Information Center

    Hulbert, T. P.

    1994-01-01

    Clinical features, pathogenetic hypotheses, and symptoms of the cardio-auditory or surdo-cardiac disorder first reported by Jervell and Lange-Nielsen are described, and methods of diagnosis and treatment are presented, to alert teachers and other professionals to potentially life-threatening symptoms they may observe when working with deaf and…

  13. Language Acquisition in a Child with Cornelia De Lange Syndrome.

    ERIC Educational Resources Information Center

    Goodban, Marjorie T.

    The paper describes a successful attempt to stimulate expressive language in Becky, a young child with Cornelia de Lange syndrome, a condition characterized by moderate to severe mental retardation, dwarfed stature, and excessive body hair. The child participated in infant stimulation and individual speech therapy and her expressive output has…

  14. Self-Injury in the De Lange Syndrome.

    ERIC Educational Resources Information Center

    Singh, N. N.; Pulman, Ruth M.

    1979-01-01

    Psychological treatment techniques for the control of self-injury in a 13-year-old male with de Lange syndrome (a rare disorder characterized by retarded mental and physical development) are presented. Techniques, which included mild punishment, time out, and differential reinforcement, produced a clinically significant control of self-injurious…

  15. Characteristics of Autism Spectrum Disorder in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Moss, Jo; Howlin, Patricia; Magiati, Iliana; Oliver, Chris

    2012-01-01

    Background: The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in Cornelia de Lange syndrome (CdLS). However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. In this study we examine the ASD profile in CdLS in…

  16. The complete mitochondrial genome of the Huang Lang chicken.

    PubMed

    Yu, Qi-Fang; Liu, Li-Li; Fu, Chen-Xing; He, Shao-Ping; Li, Si; He, Jian-Hua

    2016-01-01

    Huang Lang chicken is the native breed of Hunan province in China. The complete mitochondrial (mt) genome sequence plays an important role in the accurate determination of phylogenetic relationships among metazoans. It is the first time that the complete mt genome sequence of the Huang Lang chicken was reported in this work, which was determined through the polymerase chain reaction-based method. The total length of the mitogenome is 16,786 bp, with the base composition of 30.25% for A, 23.71% for T, 32.53% for C and 13.51% for G, in the order C > A > T > G feature occurs in the Huang Lang chicken. It contains the typical structure, including two ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes and 1 non-coding control region (D-loop region). The complete mt genome sequence of the Huang Lang chicken provided an important data for further study on the genetic mechanism.

  17. Some applications of SIMS in conservation science, archaeometry and cosmochemistry

    NASA Astrophysics Data System (ADS)

    McPhail, D. S.

    2006-07-01

    Some applications of SIMS in conservation science, archaeometry and cosmochemistry are described. Ultra-low energy SIMS depth profiling and TOF-SIMS imaging are used to study the corrosion of low-lime glass vessels from the V&A museum. Static SIMS and focused ion beam (FIB) SIMS are used to study the effects of laser cleaning on museum artefacts. Archaeological glass from Raqqa, Syria is studied with FIB-SIMS and micrometeorite impacts on space vessels are studied with FIB and FIB-SIMS. The new analytical challenges provided to the SIMS community by these materials are presented and the ethical issues associated with sampling and destructive analysis discussed.

  18. Online estimation of Allan variance coefficients based on a neural-extended Kalman filter.

    PubMed

    Miao, Zhiyong; Shen, Feng; Xu, Dingjie; He, Kunpeng; Tian, Chunmiao

    2015-01-23

    As a noise analysis method for inertial sensors, the traditional Allan variance method requires the storage of a large amount of data and manual analysis for an Allan variance graph. Although the existing online estimation methods avoid the storage of data and the painful procedure of drawing slope lines for estimation, they require complex transformations and even cause errors during the modeling of dynamic Allan variance. To solve these problems, first, a new state-space model that directly models the stochastic errors to obtain a nonlinear state-space model was established for inertial sensors. Then, a neural-extended Kalman filter algorithm was used to estimate the Allan variance coefficients. The real noises of an ADIS16405 IMU and fiber optic gyro-sensors were analyzed by the proposed method and traditional methods. The experimental results show that the proposed method is more suitable to estimate the Allan variance coefficients than the traditional methods. Moreover, the proposed method effectively avoids the storage of data and can be easily implemented using an online processor.

  19. G-SIMS of crystallisable organics

    NASA Astrophysics Data System (ADS)

    Gilmore, I. S.; Seah, M. P.

    2003-01-01

    In this study, the gentle SIMS (G-SIMS) concept has been applied to the crystallisable organic materials of Irganox 1010, caffeine, cholesterol, glucose, poly- L-lysine and bovine serum albumin. These are chosen to represent as wide a range of material types as possible. For each case, the G-SIMS spectra are considerably simpler than the static SIMS, enabling direct interpretation and identification. It is demonstrated that the amount of fragmentation in the mass spectrum may be controlled numerically and this information can be used to re-assemble the parent molecule. Wherever possible, the use of dual column ion beams is recommended to eliminate alignment requirements. Additionally, the total electron beam fluence should be kept below 6×10 18 electrons/m 2 to prevent electron damage.

  20. Precision Astrometry - Observing With SIM Planetquest

    NASA Astrophysics Data System (ADS)

    Unwin, Stephen C.

    2007-05-01

    Precision astrometry at the microarcsecond accuracy provides critical data for a wide range of problems in astrophysics -- from detection and mass determination of Earth-like extrasolar planets, to testing models of stellar structure, to the dynamics and evolutionary history of our Milky Way Galaxy and the Local Group, including the role of dark matter. NASA's SIM PlanetQuest is a versatile instrument for 'precision astrophysics'. Not only can SIM reach faint targets, but it can be flexibly scheduled to optimize the observations for maximum science return. About half of the observing time will be made available through a competed General Observer program, which will cover any topic for which microarcsecond astrometry is key. SIM will have a differential accuracy of 1 μas in a single measurement. So in the search for extrasolar planets, SIM could detect an Earth orbiting in the 'habitable zone' around every one of the nearest 64 Sun-like stars, as well as surveying the architectures of 2000 systems for those that resemble our solar System. With a global astrometric accuracy of 4 μas, SIM can measure accurate distances and luminosities of many types of stars, and through binary orbits, measure dynamical stellar masses to 1 %, which is currently very hard -- especially for exotic systems such as neutron stars and black holes. By determining the proper motions of stellar populations in the Galaxy, SIM will probe the Galactic mass distribution, and through studies of tidal tails, the formation and evolution of the halo. SIM will use astrometry to probe the structure and dynamics of the variable nuclei of active galaxies. SIM completed its technology development program in 2005, and is being developed for flight in the next decade. This work was performed at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA.

  1. Astrophysics with SIM PlanetQuest

    NASA Astrophysics Data System (ADS)

    Edberg, S. J.

    2005-12-01

    This poster serves to introduce a series of posters discussing Space Interferometry Mission PlanetQuest (SIM PlanetQuest) science prospects and plans across a wide range of astrophysics. SIM is being designed and built for NASA's Navigator Program, an element of the Astronomical Search for Origins and Planetary Systems theme in the Science Mission Directorate. It will be the first optical interferometer in space dedicated to precision astrometry. Even though SIM PlanetQuest has undergone a significant redesign since last year, the principle parameters of the instrument and anticipated results from its flight have changed little. With astrometric modes yielding 1 microarcsecond and 4 microarcsecond measurements, SIM offers the opportunity to investigate a wide variety of phenomena. From effects due to planetary gravitation within the solar system to investigating the emission phenomena of quasars and AGNs, SIM will provide breakthrough science. SIM astrometry will provide positions, parallaxes (distances), and proper motions with unprecedented accuracies for thousands of stars. Searches for Earth-like planets will be made. Investigations of other planetary systems are possible, including the masses and orbits of their planets. Characterizations of stellar masses, from brown dwarfs to stellar-mass black holes and across the H-R diagram are planned. Combined with ground-based observations, SIM observations of MACHOs should yield the masses of the microlensing objects for the first time. The ages of globular clusters will be determined and the Milky Way's mass and its distribution will benefit from the study of halo and tidal tail stars. SIM measurements of the motions of Local Group galaxies will enable tests of models of this system. Quasar jets will be investigated and quasars themselves can be used to tie down a significantly improved celestial reference frame. This work was performed for the Jet Propulsion Laboratory, California Institute of Technology, sponsored

  2. Arc Magma Genesis from Melting of Mélange Diapirs

    NASA Astrophysics Data System (ADS)

    Cruz-Uribe, A. M.; Marschall, H.; Gaetani, G. A.

    2015-12-01

    Alkaline basalts occur in many subduction-related volcanic settings, including the Sunda, Izu-Bonin, Honshu, Aeolian, and Aleutian arcs, yet their origin continues to be debated. Recent studies have suggested that buoyant material (mélange) from the slab-wedge interface may rise into the hot corner of the mantle wedge as low-density plumes or diapirs, where it will melt or induce mantle melting due to dehydration. High-pressure mélange rocks represent a mixture of mafic, ultramafic, and sedimentary components, and are often dominated by chlorite. Mélange rocks are also enriched in accessory phases such as monazite, zircon, and rutile, which host a variety of trace elements. We present results from experimental melting of chlorite-rich mélange material at mantle wedge conditions that reproduce many of the compositional features of subduction-related lavas. Piston cylinder experiments were performed at conditions appropriate for mantle wedge diapirs (1030-1280 °C, 1.5-2.5 GPa) using natural mélange rocks from Syros, Greece. Experimental melts derived from omphacite-epidote-phengite bearing chlorite schists range in composition from basaltic trachyandesites to trachydacites to more alkaline melt compositions (50.7-60.73 wt% SiO2, 7.48-12.93 wt% Na2O+K2O). All of the experimental melts are characterized by high alumina contents (16.79-21.36 wt% Al2O3). Minerals coexisting with these melts include clinopyroxene, amphibole (at lower T) or olivine (at higher T), garnet (at higher P), ilmenite and/or rutile, and zircon. Trace element patterns in our experimentally produced melts are similar to those from arc volcanoes worldwide. Experimental melts are enriched in large ion lithophile elements (Cs, Rb, Ba, K, Pb, Sr) and depleted in high field strength elements (Nb, Ta, and Ti). Zirconium and Hf are enriched relative to the rare earth elements (REE), which show flat to heavy REE depleted patterns depending on the presence of residual garnet. Thorium is fractionated

  3. Application of Allan Deviation to Assessing Uncertainties of Continuous-measurement Instruments, and Optimizing Calibration Schemes

    NASA Astrophysics Data System (ADS)

    Jacobson, Gloria; Rella, Chris; Farinas, Alejandro

    2014-05-01

    Technological advancement of instrumentation in atmospheric and other geoscience disciplines over the past decade has lead to a shift from discrete sample analysis to continuous, in-situ monitoring. Standard error analysis used for discrete measurements is not sufficient to assess and compare the error contribution of noise and drift from continuous-measurement instruments, and a different statistical analysis approach should be applied. The Allan standard deviation analysis technique developed for atomic clock stability assessment by David W. Allan [1] can be effectively and gainfully applied to continuous measurement instruments. As an example, P. Werle et al has applied these techniques to look at signal averaging for atmospheric monitoring by Tunable Diode-Laser Absorption Spectroscopy (TDLAS) [2]. This presentation will build on, and translate prior foundational publications to provide contextual definitions and guidelines for the practical application of this analysis technique to continuous scientific measurements. The specific example of a Picarro G2401 Cavity Ringdown Spectroscopy (CRDS) analyzer used for continuous, atmospheric monitoring of CO2, CH4 and CO will be used to define the basics features the Allan deviation, assess factors affecting the analysis, and explore the time-series to Allan deviation plot translation for different types of instrument noise (white noise, linear drift, and interpolated data). In addition, the useful application of using an Allan deviation to optimize and predict the performance of different calibration schemes will be presented. Even though this presentation will use the specific example of the Picarro G2401 CRDS Analyzer for atmospheric monitoring, the objective is to present the information such that it can be successfully applied to other instrument sets and disciplines. [1] D.W. Allan, "Statistics of Atomic Frequency Standards," Proc, IEEE, vol. 54, pp 221-230, Feb 1966 [2] P. Werle, R. Miicke, F. Slemr, "The Limits

  4. Chromosome 13q deletion with Cornelia de Lange syndrome phenotype.

    PubMed

    Ngo, C T; Alhady, M; Tan, A K; Norlasiah, I Siti; Ong, G B; Chua, C N

    2007-03-01

    A 3-year-old girl with facial dysmorphic features suggestive of Cornelia de Lange syndrome was seen in the ophthalmology unit for a right leukocoria. The leukocoria was found to be caused by a large retinoblastoma and the right eye was enucleated. Chromosomal analysis revealed partial chromosome 13q deletion involving band 14 which is associated with a high risk of retinoblastoma. This case shows that patient with chromosome 13q deletion syndrome cannot be diagnosed based on dysmorphic features only. Chromosomal analysis is warranted in all infants with facial dysmorphism suggestive of Cornelia de Lange syndrome so that those with chromosome 13q deletion can be referred early for early detection of retinoblastoma.

  5. Autosomal dominant inheritance of Brachmann-de Lange syndrome

    SciTech Connect

    Kozma, C.

    1996-12-30

    A mother with mild phenotype and her severely affected son, both with classic manifestations of Brachmann-de Lange syndrome (BDLS), are described. This documented mother-to-child transmission supports the hypothesis of autosomal dominant transmission with intrafamilial variability. Known cases of BDLS with autosomal dominant inheritance are reviewed. Although most cases of BDLS are sporadic, a careful evaluation of parents of affected children is important for appropriate genetic counseling. 15 refs., 3 figs., 1 tab.

  6. New Science With SIM Lite: Introduction to the SIM Science Studies

    NASA Astrophysics Data System (ADS)

    Unwin, Stephen C.

    2009-01-01

    The Space Interferometry Mission Lite (SIM Lite) will be the first optical interferometer in space designed for precision astrometry to 4 microarcseconds, on targets as faint as V=19. This flexibly-scheduled instrument will tackle a range of problems in modern astrophysics. In 2008, the SIM Lite Project and the NASA Exoplanet Science Institute (NExScI) solicited proposals for an opportunity entitled "SIM Science Studies". A total of 19 SIM Lite study projects were selected by an independent review panel. This paper is an introduction to the broad range of science topics represented by the studies. The purpose of the Studies is to enhance the science return from SIM Lite by supporting researchers to conduct concept studies that will lead to the most scientifically productive observations. The scope included all areas of astrophysics that are enabled by precision astrometry - including, modeling of dynamical or physical processes to be studied with SIM, the selection of suitable targets, assessment of instrument performance, and design of observing sequences to take best advantage of SIM Lite's flexible scheduling. These studies will stimulate new groups of researchers from our astronomy community to prepare the groundwork for the most effective use of SIM observing time in the future. The research described in this paper was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

  7. Oxygen isotope geospeedometry by SIMS

    NASA Astrophysics Data System (ADS)

    Bonamici, C. E.; Valley, J. W.

    2013-12-01

    Geospeedometry, a discipline closely related and complimentary to thermochronology, exploits the phenomenon of diffusion in order to extract rate and duration information for segments of a rock's thermal history. Geospeedometry data, when anchored in absolute time by geochronologic data, allow for the construction of detailed temperature-time paths for specific terranes and geologic processes. We highlight the developing field of SIMS-based oxygen isotope geospeedometry with an application from granulites of the Adirondack Mountains (New York) and discuss potential future applications based on a recently updated and expanded modeling tool, the Fast Grain Boundary diffusion program (FGB; Eiler et al. 1994). Equilibrium oxygen isotope ratios in minerals are a function of temperature and bulk rock composition. In dynamic systems, intragrain oxygen isotope zoning can develop in response to geologic events that affect the thermal state of a rock and/or induce recrystallization, especially tectonic deformation and fluid infiltration. As an example, titanite grains from late-Grenville shear zones in the northwestern Adirondack Mountains exhibit a range of δ18O zoning patterns that record post-peak metamorphic cooling, episodic fluid infiltration, and deformation-facilitated recrystallization. Many titanite grains preserve smooth, core-to-rim decreasing, diffusional δ18O profiles, which are amenable to diffusion modeling. FGB models that best fit the measured δ18O profiles indicate cooling from ~700-500°C in just 2-5 m.y., a rapid thermal change signaling the final gravitational collapse of the late-Grenville orogen. Titanite can also be utilized as a U-Pb chronometer, and comparison of δ18O and U-Pb age zoning patterns within the Adirondack titanites pins the episode of rapid cooling inferred from the δ18O record to some time between 1054 and 1047 Ma. The expanded capabilities of FGB also allow for evaluation of a range of heating-cooling histories for the

  8. Stellar and Galactic Astrophysics with SIM

    NASA Astrophysics Data System (ADS)

    Gould, A.

    2001-05-01

    SIM will revolutionize stellar and Galactic astrophysics by tackling new questions that could never previously be addressed and making order of magnitude improvements in key parameters. SIM will measure R0 and Theta0 to <2 will enable precise measurements of the Milky Way mass and rotation curve. It will probe the Galactic 3-D mass distribution by 2 independent methods. By calibrating the RR Lyrae MV-[Fe/H] relation as well as obtaining direct distances to clusters and halo field objects, SIM will precisely date halo and globular-cluster formation as a function of metallicity. SIM will obtain 1 measurements for 200 stars of all types ranging from brown dwarfs (BD) to O stars from a broad range of metallicities, including both binaries and single stars, and it will yield precision measurements of white dwarf (WD) and black hole (BH) remnants as well. SIM microlensing will take an unbiased census of all objects in the Galactic bulge, both dark (BD WD NS BH) and luminous, and will resolve the nature of the dark-halo (MACHO) candidates currently being detected toward the LMC.

  9. Observation, Inference, and Imagination: Elements of Edgar Allan Poe's Philosophy of Science

    ERIC Educational Resources Information Center

    Gelfert, Axel

    2014-01-01

    Edgar Allan Poe's standing as a literary figure, who drew on (and sometimes dabbled in) the scientific debates of his time, makes him an intriguing character for any exploration of the historical interrelationship between science, literature and philosophy. His sprawling "prose-poem" "Eureka" (1848), in particular, has…

  10. Politics and Education in America's Multicultural Society: An African-American Studies' Response to Allan Bloom.

    ERIC Educational Resources Information Center

    Hayes, Floyd W., III

    1989-01-01

    In "The Closing of the American Mind," Allan Bloom responds to educational problems by blaming African-Americans for creating a separate intellectual world. He blames universities for retreating from traditional education which stresses the supremacy of Western ideals. His neo-conservatism dominates current educational policy and must be…

  11. Observation, Inference, and Imagination: Elements of Edgar Allan Poe's Philosophy of Science

    ERIC Educational Resources Information Center

    Gelfert, Axel

    2014-01-01

    Edgar Allan Poe's standing as a literary figure, who drew on (and sometimes dabbled in) the scientific debates of his time, makes him an intriguing character for any exploration of the historical interrelationship between science, literature and philosophy. His sprawling "prose-poem" "Eureka" (1848), in particular, has…

  12. European Studies as Answer to Allan Bloom's "The Closing of the American Mind."

    ERIC Educational Resources Information Center

    Macdonald, Michael H.

    European studies can provide a solution to several of the issues raised in Allan Bloom's "The Closing of the American Mind." European studies pursue the academic quest for what is truth, what is goodness, and what is beauty. In seeking to answer these questions, the Greeks were among the first to explore many of humanity's problems and…

  13. The Art of George Morrison and Allan Houser: The Development and Impact of Native Modernism

    ERIC Educational Resources Information Center

    Montiel, Anya

    2005-01-01

    The idea for a retrospective on George Morrison and Allan Houser as one of the inaugural exhibitions at the National Museum of the American Indian (NMAI) came from the NMAI curator of contemporary art, Truman Lowe. An artist and sculptor himself, Lowe knew both artists personally and saw them as mentors and visionaries. Lowe advised an exhibition…

  14. Playing on the Right Side of the Brain: An Interview with Allan N. Schore

    ERIC Educational Resources Information Center

    American Journal of Play, 2017

    2017-01-01

    Allan N. Schore has served on the clinical faculty of the Department of Psychiatry and Biobehavioral Sciences at UCLA's David Geffen School of Medicine since 1996 and has maintained a private clinical practice for more than four decades. He has contributed significant research to the disciplines of interpersonal neurobiology, affective…

  15. The Art of George Morrison and Allan Houser: The Development and Impact of Native Modernism

    ERIC Educational Resources Information Center

    Montiel, Anya

    2005-01-01

    The idea for a retrospective on George Morrison and Allan Houser as one of the inaugural exhibitions at the National Museum of the American Indian (NMAI) came from the NMAI curator of contemporary art, Truman Lowe. An artist and sculptor himself, Lowe knew both artists personally and saw them as mentors and visionaries. Lowe advised an exhibition…

  16. Horror from the Soul--Gothic Style in Allan Poe's Horror Fictions

    ERIC Educational Resources Information Center

    Sun, Chunyan

    2015-01-01

    Edgar Allan Poe made tremendous contribution to horror fiction. Poe's inheritance of gothic fiction and American literature tradition combined with his living experience forms the background of his horror fictions. He inherited the tradition of the gothic fictions and made innovations on it, so as to penetrate to subconsciousness. Poe's horror…

  17. An Interview with Allan Wigfield: A Giant on Research on Expectancy Value, Motivation, and Reading Achievement

    ERIC Educational Resources Information Center

    Bembenutty, Hefer

    2012-01-01

    This article presents an interview with Allan Wigfield, professor and chair of the Department of Human Development and distinguished scholar-teacher at the University of Maryland. He has authored more than 100 peer-reviewed journal articles and book chapters on children's motivation and other topics. He is a fellow of Division 15 (Educational…

  18. Where Were the Whistleblowers? The Case of Allan McDonald and Roger Boisjoly.

    ERIC Educational Resources Information Center

    Stewart, Lea P.

    Employees who "blow the whistle" on their company because they believe it is engaged in practices that are illegal, immoral, or harmful to the public, often face grave consequences for their actions, including demotion, harassment, forced resignation, or termination. The case of Allan McDonald and Roger Boisjoly, engineers who blew the…

  19. Allan deviation computations of a linear frequency synthesizer system using frequency domain techniques

    NASA Technical Reports Server (NTRS)

    Wu, Andy

    1995-01-01

    Allan Deviation computations of linear frequency synthesizer systems have been reported previously using real-time simulations. Even though it takes less time compared with the actual measurement, it is still very time consuming to compute the Allan Deviation for long sample times with the desired confidence level. Also noises, such as flicker phase noise and flicker frequency noise, can not be simulated precisely. The use of frequency domain techniques can overcome these drawbacks. In this paper the system error model of a fictitious linear frequency synthesizer is developed and its performance using a Cesium (Cs) atomic frequency standard (AFS) as a reference is evaluated using frequency domain techniques. For a linear timing system, the power spectral density at the system output can be computed with known system transfer functions and known power spectral densities from the input noise sources. The resulting power spectral density can then be used to compute the Allan Variance at the system output. Sensitivities of the Allan Variance at the system output to each of its independent input noises are obtained, and they are valuable for design trade-off and trouble-shooting.

  20. Allan Bloom, Mike Rose, and Paul Goodman: In Search of a Lost Pedagogical Synthesis.

    ERIC Educational Resources Information Center

    Smith, Jeff

    1993-01-01

    Discusses and compares two recent books on American higher education: "The Closing of the American Mind" by Allan Bloom, and "Lives on the Boundary" by Mike Rose. Develops a view which synthesizes those of Bloom and Rose. Considers this view as comparable to that of Paul Goodman. (HB)

  1. The Allan variance in the presence of a compound Poisson process modelling clock frequency jumps

    NASA Astrophysics Data System (ADS)

    Formichella, Valerio

    2016-12-01

    Atomic clocks can be affected by frequency jumps occurring at random times and with a random amplitude. The frequency jumps degrade the clock stability and this is captured by the Allan variance. In this work we assume that the random jumps can be modelled by a compound Poisson process, independent of the other stochastic and deterministic processes affecting the clock stability. Then, we derive the analytical expression of the Allan variance of a jumping clock. We find that the analytical Allan variance does not depend on the actual shape of the jumps amplitude distribution, but only on its first and second moments, and its final form is the same as for a clock with a random walk of frequency and a frequency drift. We conclude that the Allan variance cannot distinguish between a compound Poisson process and a Wiener process, hence it may not be sufficient to correctly identify the fundamental noise processes affecting a clock. The result is general and applicable to any oscillator, whose frequency is affected by a jump process with the described statistics.

  2. An Interview with Allan Wigfield: A Giant on Research on Expectancy Value, Motivation, and Reading Achievement

    ERIC Educational Resources Information Center

    Bembenutty, Hefer

    2012-01-01

    This article presents an interview with Allan Wigfield, professor and chair of the Department of Human Development and distinguished scholar-teacher at the University of Maryland. He has authored more than 100 peer-reviewed journal articles and book chapters on children's motivation and other topics. He is a fellow of Division 15 (Educational…

  3. Allan M. Freedman, LLB: a lawyer’s gift to Canadian chiropractors

    PubMed Central

    Brown, Douglas M.

    2007-01-01

    This paper reviews the leadership role, contributions, accolades, and impact of Professor Allan Freedman through a 30 year history of service to CMCC and the chiropractic profession in Canada. Professor Freedman has served as an educator, philanthropist and also as legal counsel. His influence on chiropractic organizations and chiropractors during this significant period in the profession is discussed. PMID:18060008

  4. Cornelia de Lange Syndrome: A Newborn with Imperforate Anus and a NIPBL Mutation

    PubMed Central

    Mende, Rose H.; Drake, David P.; Olomi, Raimos M.; Hamel, Ben C. J.

    2012-01-01

    Cornelia de Lange syndrome is a dominantly inherited, genetically heterogeneous and clinically variable syndrome with multiple congenital anomalies and developmental delay. Gastrointestinal anomalies are common and an important cause of morbidity and mortality. We report on a newborn with a molecularly confirmed Cornelia de Lange syndrome who had an imperforate anus. This is the third report of Cornelia de Lange syndrome and imperforate anus. PMID:23304577

  5. Discovery of Planetary Systems With SIM

    NASA Technical Reports Server (NTRS)

    Marcy, Geoffrey W.; Butler, Paul R.; Frink, Sabine; Fischer, Debra; Oppenheimer, Ben; Monet, David G.; Quirrenbach, Andreas; Scargle, Jeffrey D.

    2004-01-01

    We are witnessing the birth of a new observational science: the discovery and characterization of extrasolar planetary systems. In the past five years, over 70 extrasolar planets have been discovered by precision Doppler surveys, most by members of this SIM team. We are using the data base of information gleaned from our Doppler survey to choose the best targets for a new SIN planet search. In the same way that our Doppler database now serves SIM, our team will return a reconnaissance database to focus Terrestrial Planet Finder (TPF) into a more productive, efficient mission.

  6. Discrete Lange-Newell criterion for dissipative systems

    NASA Astrophysics Data System (ADS)

    Ndzana, Fabien, II; Mohamadou, Alidou; Kofané, Timoleon Crépin

    2009-05-01

    We report on the derivation of the discrete complex Ginzburg-Landau equation with first- and second-neighbor couplings using a nonlinear electrical network. Furthermore, we discuss theoretically and numerically modulational instability of plane carrier waves launched through the line. It is pointed out that the underlying analysis not only spells out the discrete Lange-Newell criterion by the means of the linear stability analysis at which the modulational instability occurs for the generation of a train of ultrashort pulses, but also characterizes the long-time dynamical behavior of the system when the instability grows.

  7. Cornelia de Lange syndrome: What every otolaryngologist should know.

    PubMed

    Eliason, Michael J; Melzer, Jonathan M; Gallagher, Thomas Q

    2017-08-01

    Cornelia de Lange Syndrome (CdLS) can be expressed in multiple organ systems requiring a variety of specialists, including pediatric otolaryngology. We present the case of a 20-month-old boy with CdLS actively managed by an aerodigestive team consisting of pediatric otolaryngology, pediatric pulmonology, pediatric gastroenterology, with support staff from audiology, speech, and nutrition. His presentation included mixed hearing loss, dysphagia, microaspiration, gastroesophageal reflux, and failure to thrive. We submit this challenging case of CdLS with a review of the literature to focus specific attention on the otolaryngic manifestations of the syndrome and to discuss the benefits of a multidisciplinary approach to these unique patients.

  8. Discrete Lange-Newell criterion for dissipative systems.

    PubMed

    Ndzana, Fabien I I; Mohamadou, Alidou; Kofané, Timoleon Crépin

    2009-05-01

    We report on the derivation of the discrete complex Ginzburg-Landau equation with first- and second-neighbor couplings using a nonlinear electrical network. Furthermore, we discuss theoretically and numerically modulational instability of plane carrier waves launched through the line. It is pointed out that the underlying analysis not only spells out the discrete Lange-Newell criterion by the means of the linear stability analysis at which the modulational instability occurs for the generation of a train of ultrashort pulses, but also characterizes the long-time dynamical behavior of the system when the instability grows.

  9. Design data brochure: SIMS prototype system 2

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Information is provided on the design and performance of the IBM SIMS Prototype System 2, solar domestic hot water system, for single family residences. The document provides sufficient data to permit procurement, installation, operation, and maintenance by qualified architectural engineers or contractors.

  10. A Sim(2) invariant dimensional regularization

    NASA Astrophysics Data System (ADS)

    Alfaro, J.

    2017-09-01

    We introduce a Sim (2) invariant dimensional regularization of loop integrals. Then we can compute the one loop quantum corrections to the photon self energy, electron self energy and vertex in the Electrodynamics sector of the Very Special Relativity Standard Model (VSRSM).

  11. SIM-PlanetQuest: progress report

    NASA Astrophysics Data System (ADS)

    Marr, James C., IV

    2006-06-01

    SIM-PlanetQuest is a NASA astrophysics mission that is implementing the National Research Counsel's recommended Astrometric Interferometry Mission (AIM) to develop the first, in-space, optical, long-baseline Michelson Stellar Interferometer for performing micro-arcsecond-level astrometry. This level of astrometric precision will enable characterization of planetary systems around nearby stars and enable a number of key investigations in astrophysics including calibration of the cosmological distance scale, stellar and galactic structure and evolution, and dark matter/energy distribution. This paper provides an update on the SIM-PlanetQuest Mission covering the results of the 2005 mission redesign and the recent completion of the last in a series of technology "gates." The SIM-PlanetQuest mission redesign was directed by NASA to recover eroded mass and power margins and to meet specific implementation cost targets. The resulting mission redesign met all redesign objectives with minimal impact to mission science performance. This paper provides the mission redesign objectives and describes the resulting mission and system design including changes in science capability. SIM-PlanetQuest also completed the last of eight major technology development gates that were established in 2001 by NASA, completing the enabling technology development. The technology development program, the last gate, and its significance to the project's flight verification and validation (V&V) approach are briefly described (covered in more detail in a separate paper at this conference). An update on project programmatic status and plans is also provided.

  12. siMS Score: Simple Method for Quantifying Metabolic Syndrome

    PubMed Central

    Soldatovic, Ivan; Vukovic, Rade; Culafic, Djordje; Gajic, Milan; Dimitrijevic-Sreckovic, Vesna

    2016-01-01

    Objective To evaluate siMS score and siMS risk score, novel continuous metabolic syndrome scores as methods for quantification of metabolic status and risk. Materials and Methods Developed siMS score was calculated using formula: siMS score = 2*Waist/Height + Gly/5.6 + Tg/1.7 + TAsystolic/130—HDL/1.02 or 1.28 (for male or female subjects, respectively). siMS risk score was calculated using formula: siMS risk score = siMS score * age/45 or 50 (for male or female subjects, respectively) * family history of cardio/cerebro-vascular events (event = 1.2, no event = 1). A sample of 528 obese and non-obese participants was used to validate siMS score and siMS risk score. Scores calculated as sum of z-scores (each component of metabolic syndrome regressed with age and gender) and sum of scores derived from principal component analysis (PCA) were used for evaluation of siMS score. Variants were made by replacing glucose with HOMA in calculations. Framingham score was used for evaluation of siMS risk score. Results Correlation between siMS score with sum of z-scores and weighted sum of factors of PCA was high (r = 0.866 and r = 0.822, respectively). Correlation between siMS risk score and log transformed Framingham score was medium to high for age groups 18+,30+ and 35+ (0.835, 0.707 and 0.667, respectively). Conclusions siMS score and siMS risk score showed high correlation with more complex scores. Demonstrated accuracy together with superior simplicity and the ability to evaluate and follow-up individual patients makes siMS and siMS risk scores very convenient for use in clinical practice and research as well. PMID:26745635

  13. Cornelia de-lange syndrome: a case report.

    PubMed

    Mehta, Diana Noshir; Bhatia, Rupinder

    2013-05-01

    Cornelia de-Lange syndrome is a congenital anomaly syndrome characterized by distinctive facial dysmorphism, primordial short stature, hirsutism, and upper limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly. Craniofacial features include synophrys, arched eyebrows, long eyelashes, small widely spaced teeth and microcephaly. IQ ranges from between 30 and 102 with an average of 53. Many individuals demonstrate autistic and self-destructive tendencies. It is an autosomal dominant disorder caused by specific gene mutations and occurrence is one in 30,000 to 50,000 children. This article describes a report of a classical case of the syndrome of a 10-year-old boy and emphasizes the oral and systemic findings. The role of the pediatric dentist, with his expertize in prevention, skills of behavior management and timely referral to medical speciality, is of paramount importance in the management of children with this syndrome. How to cite this article: Mehta DN, Bhatia R. Cornelia De-Lange Syndrome: A Case Report. Int J Clin Pediatr Dent 2013;6(2):115-118.

  14. Cornelia De-Lange Syndrome: A Case Report

    PubMed Central

    Bhatia, Rupinder

    2013-01-01

    ABSTRACT Cornelia de-Lange syndrome is a congenital anomaly syndrome characterized by distinctive facial dysmorphism, primordial short stature, hirsutism, and upper limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly. Craniofacial features include synophrys, arched eyebrows, long eyelashes, small widely spaced teeth and microcephaly. IQ ranges from between 30 and 102 with an average of 53. Many individuals demonstrate autistic and self-destructive tendencies. It is an autosomal dominant disorder caused by specific gene mutations and occurrence is one in 30,000 to 50,000 children. This article describes a report of a classical case of the syndrome of a 10-year-old boy and emphasizes the oral and systemic findings. The role of the pediatric dentist, with his expertize in prevention, skills of behavior management and timely referral to medical speciality, is of paramount importance in the management of children with this syndrome. How to cite this article: Mehta DN, Bhatia R. Cornelia De-Lange Syndrome: A Case Report. Int J Clin Pediatr Dent 2013;6(2):115-118. PMID:25206204

  15. Evolution of Ice Mélange Motion During Periods of Terminus Quiescence

    NASA Astrophysics Data System (ADS)

    Cassotto, R.; Amundson, J. M.; Fahnestock, M. A.; Truffer, M.; Burton, J. C.; Kuo, C. C.; Dennin, M.; Boettcher, M. S.

    2016-12-01

    Variations in the strength of ice mélange, a dense matrix of icebergs and sea ice retained in many proglacial fjords, has been proposed as a key process influencing the stability of tidewater glaciers in Greenland [Straneo et al., 2013]. Several observational studies have shown that variations in ice mélange characteristics often precede changes in speed and calving rates along glacier termini. A full understanding of the resistance provided by ice mélange, and therefore its impact on glacier stability, requires knowledge of its granular rheology. Toward this goal, we present unique terrestrial radar interferometry (TRI) observations of the ice mélange at Jakobshavn Isbræ, Greenland that was acquired at very high spatial (meters) and temporal (minutes) resolution during summer 2012. Data was collected over a 15-day period, during which several large calving events occurred. Previous work [Peters et al., 2015] described the dynamic jamming of the ice mélange that was observed during calving events. Here, we focus on the more gradual evolution of the ice mélange during periods of terminus quiescence. We look at variations in velocity and strain rate and consider how glacier motion, ocean currents, tides, and wind affect motion of the ice mélange. Our aim is to provide the most comprehensive study of ice mélange rheology to date.

  16. The Association Between Environmental Events and Self-Injurious Behaviour in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Moss, J.; Oliver, C.; Hall, S.; Arron, K.; Sloneem, J.; Petty, J.

    2005-01-01

    There has been limited empirical research into the environmental causes of self-injury in Cornelia de Lange syndrome. The present study examined the variability of self-injurious behaviour in Cornelia de Lange syndrome across environmental setting events. Additionally, the association between setting events and more specific environmental events…

  17. Prevalence of Autism Spectrum Phenomenology in Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna F.; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

    2008-01-01

    Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat…

  18. A Boy with a Mild Case of Cornelia de Lange Syndrome with Above Average Intelligence.

    ERIC Educational Resources Information Center

    Lacassie, Yves; Bobadilla, Olga; Cambias, Ron D., Jr.

    1997-01-01

    Describes the characteristics of an 11-year-old boy who represents the only documented case of an individual with Cornelia de Lange syndrome who also has above average cognitive functioning. Major diagnostic criteria for de Lange syndrome and comparisons with other severe and mild cases are discussed. (Author/CR)

  19. Prevalence of Autism Spectrum Phenomenology in Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna F.; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

    2008-01-01

    Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat…

  20. Delineating the Profile of Autism Spectrum Disorder Characteristics in Cornelia de Lange and Fragile X Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna; Oliver, Chris; Nelson, Lisa; Richards, Caroline; Hall, Scott

    2013-01-01

    An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n = 182, M age = 16.94), and autism spectrum disorder (n = 142, M…

  1. The Association Between Environmental Events and Self-Injurious Behaviour in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Moss, J.; Oliver, C.; Hall, S.; Arron, K.; Sloneem, J.; Petty, J.

    2005-01-01

    There has been limited empirical research into the environmental causes of self-injury in Cornelia de Lange syndrome. The present study examined the variability of self-injurious behaviour in Cornelia de Lange syndrome across environmental setting events. Additionally, the association between setting events and more specific environmental events…

  2. A Boy with a Mild Case of Cornelia de Lange Syndrome with Above Average Intelligence.

    ERIC Educational Resources Information Center

    Lacassie, Yves; Bobadilla, Olga; Cambias, Ron D., Jr.

    1997-01-01

    Describes the characteristics of an 11-year-old boy who represents the only documented case of an individual with Cornelia de Lange syndrome who also has above average cognitive functioning. Major diagnostic criteria for de Lange syndrome and comparisons with other severe and mild cases are discussed. (Author/CR)

  3. Delineating the Profile of Autism Spectrum Disorder Characteristics in Cornelia de Lange and Fragile X Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna; Oliver, Chris; Nelson, Lisa; Richards, Caroline; Hall, Scott

    2013-01-01

    An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n = 182, M age = 16.94), and autism spectrum disorder (n = 142, M…

  4. Design of Microstrip Lange Coupler Based on Em-Ann Model

    NASA Astrophysics Data System (ADS)

    Yang, Ziqiang; Yang, Tao; Liu, Yu

    2006-10-01

    Electromagnetically trained artificial neural network (EM-ANN) model for microstrip Lange Coupler is presented. Full-wave EM analysis software is employed to characterize the Lange Coupler. The EM-ANN model is then designed using physical parameters as inputs and S-parameters as outputs. Once the EM-ANN model is trained, it can be used to find the optimal physical structure of the Lange Coupler for a given application using optimization technique. A Ka-band microstrip Lange Coupler is designed by this method. The simulated results of the Lange Coupler show that the insert loss is better than -3.64 dB; the amplitude balance is less than 0.55 dB and the phase balance is less than 0.52°from the 90°phase difference over the 30 to 40 GHz frequency range.

  5. A new LL3 chondrite, Allan Hills A79003, and observations on matrices in ordinary chondrites

    NASA Technical Reports Server (NTRS)

    Scott, E. R. D.; Taylor, G. J.; Maggiore, P.

    1982-01-01

    Allan Hills A79003 is an LL3 chondrite with a petrologic subtype of 3.4 + or - 0.2. Contrary to previous suggestions, it is not paired with other Allan Hills specimens. It contains haxonite, (Fe,Ni)23C6; shock-melted, 'fizzed' metal-troilite intergrowths; and translucent, glassy-looking Huss matrix (fine-grained, Fe-rich silicate matrix), in addition to the normal opaque and recrystallized varieties of Huss matrix. Some chondrules are partly coated with opaque matrix, others with translucent matrix. Translucent matrix is more uniform in composition and contains less S, CaO and FeO and more MgO than the opaque variety. Both kinds of matrix rimmed chondrules before consolidation of the meteorite.

  6. Allan C. Gotlib, DC, CM: A worthy Member of the Order of Canada.

    PubMed

    Brown, Douglas M

    2016-03-01

    On June 29, 2012, His Excellency the Right Honourable David Johnston, Governor General of Canada, announced 70 new appointments to the Order of Canada. Among them was Dr. Allan Gotlib, who was subsequently installed as a Member of the Order of Canada, in recognition of his contributions to advancing research in the chiropractic profession and its inter-professional integration. This paper attempts an objective view of his career, to substantiate the accomplishments that led to Dr. Gotlib receiving Canada's highest civilian honour.

  7. Cosmic-ray-produced Cl-36 and Mn-53 in Allan Hills-77 meteorites

    NASA Technical Reports Server (NTRS)

    Nishiizumi, K.; Murrell, M. T.; Arnold, J. R.; Finkel, R. C.; Elmore, D.; Ferraro, R. D.; Gove, H. E.

    1981-01-01

    Cosmic-ray-produced Mn-53 has been determined by neutron activation in nine Allan Hills-77 meteorites. Additionally, Cl-36 has been measured in seven of these objects using tandem accelerator mass spectrometry. These results, along with C-14 and Al-26 concentrations determined elsewhere, yield terrestrial ages ranging from 10,000 to 700,000 years. Weathering was not found to result in Mn-53 loss.

  8. Genesis of the Batinah mélange above the Semail ophiolite, Oman

    NASA Astrophysics Data System (ADS)

    Robertson, A. H. F.; Woodcock, N. H.

    The Batinah mélange which overlies the late Cretaceous Semail ophiolite in the northern Oman Mountains comprises mostly sedimentary rocks of deep-water facies, alkalic lavas and intrusives, all of continental margin affinities, together with smaller volumes of Semail ophiolitic and metamorphic rocks. Four intergradational textural types of mélange can be recognized. Sheet mélange has large (>1 km) intact sheets either with little intervening matrix or set in other mélange types, and with an organised sheet orientation fabric. Slab mélange is finer textured (>100 m) and more disrupted. Block mélange has smaller (> m) blocks with some matrix and a weak to random block fabric. Clast mélange is matrix-supported rudite with a weak depositional clast fabric. Structural relationships, particularly the absence of tectonic fabrics, the decreasing strength of fragment fabrics with increasing fragmentation, and the abundance of brittle fragmentation, suggest that these mélange types formed by either gravity-driven sedimentary processes or superficial sliding or thrusting of individual rock slabs. In the slab mélange, long sequences can be pieced together, passing up from Upper Triassic mafic sub-marine extrusives and sediments into radiolarian cherts, hemipelagic and redeposited limestones, and terminating in non-calcareous radiolarities with Mn-deposits of early Cretaceous age. Mafic sills are numerous. These sequences can be matched with sub-ophiolite rocks now exposed in fault corridors through the Semail. These sequences become progressively disrupted upwards in the corridors and can be traced continuously into overlying mélange, which then thins away from the corridors. We argue that, during late Cretaceous emplacement over the Arabian margin, active fault corridors split the Semail slab and acted as conduits up which sub-ophiolite rocks were supplied to the ophiolite surface. There the rocks were redisributed by superficial processes.

  9. On the Design of Attitude-Heading Reference Systems Using the Allan Variance.

    PubMed

    Hidalgo-Carrió, Javier; Arnold, Sascha; Poulakis, Pantelis

    2016-04-01

    The Allan variance is a method to characterize stochastic random processes. The technique was originally developed to characterize the stability of atomic clocks and has also been successfully applied to the characterization of inertial sensors. Inertial navigation systems (INS) can provide accurate results in a short time, which tend to rapidly degrade in longer time intervals. During the last decade, the performance of inertial sensors has significantly improved, particularly in terms of signal stability, mechanical robustness, and power consumption. The mass and volume of inertial sensors have also been significantly reduced, offering system-level design and accommodation advantages. This paper presents a complete methodology for the characterization and modeling of inertial sensors using the Allan variance, with direct application to navigation systems. Although the concept of sensor fusion is relatively straightforward, accurate characterization and sensor-information filtering is not a trivial task, yet they are essential for good performance. A complete and reproducible methodology utilizing the Allan variance, including all the intermediate steps, is described. An end-to-end (E2E) process for sensor-error characterization and modeling up to the final integration in the sensor-fusion scheme is explained in detail. The strength of this approach is demonstrated with representative tests on novel, high-grade inertial sensors. Experimental navigation results are presented from two distinct robotic applications: a planetary exploration rover prototype and an autonomous underwater vehicle (AUV).

  10. Measurements of Ultra-Stable Oscillator (USO) Allan Deviations in Space

    NASA Technical Reports Server (NTRS)

    Enzer, Daphna G.; Klipstein, William M.; Wang, Rabi T.; Dunn, Charles E.

    2013-01-01

    Researchers have used data from the GRAIL mission to the Moon to make the first in-flight verification of ultra-stable oscillators (USOs) with Allan deviation below 10 13 for 1-to-100-second averaging times. USOs are flown in space to provide stable timing and/or navigation signals for a variety of different science and programmatic missions. The Gravity Recovery and Interior Laboratory (GRAIL) mission is flying twin spacecraft, each with its own USO and with a Ka-band crosslink used to measure range fluctuations. Data from this crosslink can be combined in such a way as to give the relative time offsets of the two spacecrafts USOs and to calculate the Allan deviation to describe the USOs combined performance while orbiting the Moon. Researchers find the first direct in-space Allan deviations below 10(exp -13) for 1-to-100-second averaging times comparable to pre-launch data, and better than measurements from ground tracking of an X-band carrier coherent with the USO. Fluctuations in Earth s atmosphere limit measurement performance in direct-to-Earth links. Inflight USO performance verification was also performed for GRAIL s parent mission, the Gravity Recovery and Climate Experiment (GRACE), using both Kband and Ka-band crosslinks.

  11. Estimating the Allan variance in the presence of long periods of missing data and outliers

    NASA Astrophysics Data System (ADS)

    Sesia, Ilaria; Tavella, Patrizia

    2008-12-01

    The ability of the Allan variance (AVAR) to identify and estimate the typical clock noise is widely accepted, and its use is recommended by international standards. Recently, a time-varying version called Dynamic Allan variance (DAVAR) was suggested and exploited. Currently, the AVAR is commonly used in applications to space and satellite systems, in particular in monitoring the clocks of the Global Positioning System, and also in the framework of the European project Galileo. In these applications stability estimation, either AVAR or DAVAR (or other similar variances), presents some peculiar aspects which are not commonly encountered when the clock data are measured in a laboratory. In particular, data from space clocks may typically present outliers and missing values. Hence, special attention has to be paid when dealing with such experimental measurements. In this work we propose an estimation algorithm and its implementation in a robust software code (in MATLAB® language) able to estimate the AVAR in the case of missing data, unequally spaced data, outliers, and with long periods of missing observation, so that the Allan variance estimates turn out unbiased and with the maximum use of all the available data.

  12. FoilSim: Basic Aerodynamics Software Created

    NASA Technical Reports Server (NTRS)

    Peterson, Ruth A.

    1999-01-01

    FoilSim is interactive software that simulates the airflow around various shapes of airfoils. The graphical user interface, which looks more like a video game than a learning tool, captures and holds the students interest. The software is a product of NASA Lewis Research Center s Learning Technologies Project, an educational outreach initiative within the High Performance Computing and Communications Program (HPCCP).This airfoil view panel is a simulated view of a wing being tested in a wind tunnel. As students create new wing shapes by moving slider controls that change parameters, the software calculates their lift. FoilSim also displays plots of pressure or airspeed above and below the airfoil surface.

  13. Topochemical Analysis of Cell Wall Components by TOF-SIMS.

    PubMed

    Aoki, Dan; Fukushima, Kazuhiko

    2017-01-01

    Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a recently developing analytical tool and a type of imaging mass spectrometry. TOF-SIMS provides mass spectral information with a lateral resolution on the order of submicrons, with widespread applicability. Sometimes, it is described as a surface analysis method without the requirement for sample pretreatment; however, several points need to be taken into account for the complete utilization of the capabilities of TOF-SIMS. In this chapter, we introduce methods for TOF-SIMS sample treatments, as well as basic knowledge of wood samples TOF-SIMS spectral and image data analysis.

  14. TOF-SIMS analysis of polymers

    NASA Astrophysics Data System (ADS)

    Wien, Karl

    1997-08-01

    When solid polymers are irradiated with heavy ions, atomic and molecular particles are ejected from the uppermost layers of the surface. A technique to determine the mass spectrum of the charged fraction of these particles is time-of-flight secondary-ion-mass spectrometry, TOF-SIMS. The present article describes, how the mass spectra measured with polymers are generally structured and under which conditions the various types of secondary ions like cationized oligomers, fragment ions and "fingerprint" ions are observable. The mechanisms leading to formation and ejection of the ions are not well understood. At bombarding energies of 10 keV, they are mainly based on atomic collision processes, at 100 MeV on the electronic excitation of the solid in the vicinity of the nuclear track. Processes, which are capable to desorb large organic molecules, seem not to work with oligomers of similar mass. Mass spectrometry of "real world" polymers, i.e. thick samples, depends mostly on the low-mass fingerprint spectrum, which can be produced by keV MeV SIMS. Modern TOF-SIMS instruments are equipped with a pulsed ion gun and an energy focussing ion mirror. They provide high mass resolution ( {m}/{Δm} ⋍ 10000 ) and high transmission (20-50%). Examples of applications are given, like the determination of mean molecular weights or investigations of radiation induced modifications of polymers.

  15. SIMS analysis: Development and evaluation program summary

    SciTech Connect

    Groenewold, G.S.; Appelhans, A.D.; Ingram, J.C.; Delmore, J.E.; Dahl, D.A.

    1996-11-01

    This report provides an overview of the ``SIMS Analysis: Development and Evaluation Program``, which was executed at the Idaho National Engineering Laboratory from mid-FY-92 to the end of FY-96. It should be noted that prior to FY-1994 the name of the program was ``In-Situ SIMS Analysis``. This report will not go into exhaustive detail regarding program accomplishments, because this information is contained in annual reports which are referenced herein. In summary, the program resulted in the design and construction of an ion trap secondary ion mass spectrometer (IT-SIMS), which is capable of the rapid analysis of environmental samples for adsorbed surface contaminants. This instrument achieves efficient secondary ion desorption by use of a molecular, massive ReO{sub 4}{sup {minus}} primary ion particle. The instrument manages surface charge buildup using a self-discharging principle, which is compatible with the pulsed nature of the ion trap. The instrument can achieve high selectivity and sensitivity using its selective ion storage and MS/MS capability. The instrument was used for detection of tri-n-butyl phosphate, salt cake (tank cake) characterization, and toxic metal speciation studies (specifically mercury). Technology transfer was also an important component of this program. The approach that was taken toward technology transfer was that of component transfer. This resulted in transfer of data acquisition and instrument control software in FY-94, and ongoing efforts to transfer primary ion gun and detector technology to other manufacturers.

  16. Mutational Screening and Prenatal Diagnosis in Cornelia de Lange syndrome.

    PubMed

    Dave, Usha; Shetty, Dhanlaxmi

    2014-02-01

    Phenotypic variability and the lack of a diagnostic marker have complicated the rapid diagnosis and genetic counseling for Cornelia de Lange syndrome (CdLS). The clinical features of CdLS are striking and easily recognizable by characteristic facial dysmorphism, upper-extremity malformations, hirsutism, cardiac defects, growth and cognitive retardation, and gastrointestinal abnormalities with severe mental retardation. The molecular diagnosis is essential for predicting prognosis and genetic counseling in the affected family, especially while planning the next pregnancy. We report here from India six cases of CdLS and how precise mutational screening in two cases helped in prenatal diagnosis and proved significant in prevention of recurrence in the affected family.

  17. On the Molecular Etiology of Cornelia de Lange Syndrome

    PubMed Central

    Dorsett, Dale; Krantz, Ian D.

    2009-01-01

    Cornelia de Lange syndrome (CdLS) is genetically heterogeneous and is usually sporadic, occurring approximately once per ten thousand births. CdLS individuals display diverse and variable deficits in growth, mental development, limbs and organs. In the past few years it has been shown that CdLS is caused by gene mutations affecting proteins involved in sister chromatid cohesion. Studies in model organisms, and more recently in human cells have revealed, somewhat unexpectedly, that the developmental deficits in CdLS likely arise from changes in gene expression. The mechanisms by which cohesion factors regulate gene expression remain to be elucidated, but current data suggest that they likely regulate transcription in multiple ways. PMID:19154515

  18. Specific neurocognitive deficits in Cornelia de Lange syndrome.

    PubMed

    Stefanatos, G A; Musikoff, H

    1994-02-01

    Cornelia de Lange Syndrome (DLS) is a dysmorphogenic disorder typically associated with severe mental retardation. This report describes a rare case with normal-range verbal intelligence and specific cognitive deficits suggestive of a developmental visuospatial disorder. This was apparent in selective deficits in the ability to integrate visual percepts, copy spatial configurations, and manipulate representations of objects in space. Visual memory and psychomotor skills were also impaired. These deficits occurred within the context of normal language abilities and language-related academic achievement. The observed pattern of neuropsychologic impairment, in addition to aspects of socioemotional development, was similar to that seen in children with developmental right-hemisphere dysfunction. These findings suggest that the factors underlying DLS can be associated with fairly specific aberrations of cortical functioning.

  19. Conformal symmetry of the Lange-Neubert evolution equation

    NASA Astrophysics Data System (ADS)

    Braun, V. M.; Manashov, A. N.

    2014-04-01

    The Lange-Neubert evolution equation describes the scale dependence of the wave function of a meson built of an infinitely heavy quark and light antiquark at light-like separations, which is the hydrogen atom problem of QCD. It has numerous applications to the studies of B-meson decays. We show that the kernel of this equation can be written in a remarkably compact form, as a logarithm of the generator of special conformal transformation in the light-ray direction. This representation allows one to study solutions of this equation in a very simple and mathematically consistent manner. Generalizing this result, we show that all heavy-light evolution kernels that appear in the renormalization of higher-twist B-meson distribution amplitudes can be written in the same form.

  20. Thrombocytopenia and Cornelia de Lange syndrome: Still an enigma?

    PubMed

    Cavalleri, Valeria; Bettini, Laura R; Barboni, Chiara; Cereda, Anna; Mariani, Milena; Spinelli, Marco; Gervasini, Cristina; Russo, Silvia; Biondi, Andrea; Jankovic, Momcilo; Selicorni, Angelo

    2016-01-01

    Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder caused by mutations in the cohesion complex and its regulators. The syndrome is characterized by multiple organ system abnormalities, pre- and post-natal growth retardation and typical facial features. Thrombocytopenia is a reduction in platelet count to <150 × 10(9)  L. It can be caused by congenital or acquired decreased production, increased destruction, or sequestration of platelets. In recent years, several papers reported thrombocytopenia and immune thrombocytopenia in patients affected by CdLS. In 2011, Lambert et al. estimated the risk of idiopathic thrombocytopenia purpura in CdLS patients to be 31-633 times greater than in the general population. We describe the incidence of thrombocytopenia in 127 Italian CdLS patients, identifying patients with transient or persistent thrombocytopenia, but a lower incidence of true idiopathic thrombocytopenic purpura (ITP).

  1. Thinning sea ice weakens buttressing force of iceberg mélange and promotes calving

    NASA Astrophysics Data System (ADS)

    Robel, Alexander A.

    2017-03-01

    At many marine-terminating glaciers, the breakup of mélange, a floating aggregation of sea ice and icebergs, has been accompanied by an increase in iceberg calving and ice mass loss. Previous studies have argued that mélange may suppress calving by exerting a buttressing force directly on the glacier terminus. In this study, I adapt a discrete element model to explicitly simulate mélange as a cohesive granular material. Simulations show that mélange laden with thick landfast sea ice produces enough resistance to shut down calving at the terminus. When sea ice within mélange thins, the buttressing force on the terminus is reduced and calving is more likely to occur. When a calving event does occur, it initiates a propagating jamming wave within mélange, which causes local compression and then slow mélange expansion. The jamming wave can also initiate widespread fracture of sea ice and further increase the likelihood of subsequent calving events.

  2. Thinning sea ice weakens buttressing force of iceberg mélange and promotes calving.

    PubMed

    Robel, Alexander A

    2017-03-01

    At many marine-terminating glaciers, the breakup of mélange, a floating aggregation of sea ice and icebergs, has been accompanied by an increase in iceberg calving and ice mass loss. Previous studies have argued that mélange may suppress calving by exerting a buttressing force directly on the glacier terminus. In this study, I adapt a discrete element model to explicitly simulate mélange as a cohesive granular material. Simulations show that mélange laden with thick landfast sea ice produces enough resistance to shut down calving at the terminus. When sea ice within mélange thins, the buttressing force on the terminus is reduced and calving is more likely to occur. When a calving event does occur, it initiates a propagating jamming wave within mélange, which causes local compression and then slow mélange expansion. The jamming wave can also initiate widespread fracture of sea ice and further increase the likelihood of subsequent calving events.

  3. Emotional Mental Imagery as Simulation of Reality: Fear and Beyond-A Tribute to Peter Lang.

    PubMed

    Ji, Julie L; Heyes, Stephanie Burnett; MacLeod, Colin; Holmes, Emily A

    2016-09-01

    This article pays tribute to the seminal paper by Peter J. Lang (1977; this journal), "Imagery in Therapy: Information Processing Analysis of Fear." We review research and clinical practice developments in the past five decades with reference to key insights from Lang's theory and experimental work on emotional mental imagery. First, we summarize and recontextualize Lang's bio-informational theory of emotional mental imagery (1977, 1979) within contemporary theoretical developments on the function of mental imagery. Second, Lang's proposal that mental imagery can evoke emotional responses is evaluated by reviewing empirical evidence that mental imagery has a powerful impact on negative as well as positive emotions at neurophysiological and subjective levels. Third, we review contemporary cognitive and behavioral therapeutic practices that use mental imagery, and consider points of extension and departure from Lang's original investigation of mental imagery in fear-extinction behavior change. Fourth, Lang's experimental work on emotional imagery is revisited in light of contemporary research on emotional psychopathology-linked individual differences in mental imagery. Finally, key insights from Lang's experiments on training emotional response during imagery are discussed in relation to how specific techniques may be harnessed to enhance adaptive emotional mental imagery training in future research.

  4. Thinning sea ice weakens buttressing force of iceberg mélange and promotes calving

    PubMed Central

    Robel, Alexander A.

    2017-01-01

    At many marine-terminating glaciers, the breakup of mélange, a floating aggregation of sea ice and icebergs, has been accompanied by an increase in iceberg calving and ice mass loss. Previous studies have argued that mélange may suppress calving by exerting a buttressing force directly on the glacier terminus. In this study, I adapt a discrete element model to explicitly simulate mélange as a cohesive granular material. Simulations show that mélange laden with thick landfast sea ice produces enough resistance to shut down calving at the terminus. When sea ice within mélange thins, the buttressing force on the terminus is reduced and calving is more likely to occur. When a calving event does occur, it initiates a propagating jamming wave within mélange, which causes local compression and then slow mélange expansion. The jamming wave can also initiate widespread fracture of sea ice and further increase the likelihood of subsequent calving events. PMID:28248285

  5. Allan Variance Computed in Space Domain: Definition and Application to InSAR Data to Characterize Noise and Geophysical Signal.

    PubMed

    Cavalié, Olivier; Vernotte, François

    2016-04-01

    The Allan variance was introduced 50 years ago for analyzing the stability of frequency standards. In addition to its metrological interest, it may be also considered as an estimator of the large trends of the power spectral density (PSD) of frequency deviation. For instance, the Allan variance is able to discriminate different types of noise characterized by different power laws in the PSD. The Allan variance was also used in other fields than time and frequency metrology: for more than 20 years, it has been used in accelerometry, geophysics, geodesy, astrophysics, and even finances. However, it seems that up to now, it has been exclusively applied for time series analysis. We propose here to use the Allan variance on spatial data. Interferometric synthetic aperture radar (InSAR) is used in geophysics to image ground displacements in space [over the synthetic aperture radar (SAR) image spatial coverage] and in time thanks to the regular SAR image acquisitions by dedicated satellites. The main limitation of the technique is the atmospheric disturbances that affect the radar signal while traveling from the sensor to the ground and back. In this paper, we propose to use the Allan variance for analyzing spatial data from InSAR measurements. The Allan variance was computed in XY mode as well as in radial mode for detecting different types of behavior for different space-scales, in the same way as the different types of noise versus the integration time in the classical time and frequency application. We found that radial Allan variance is the more appropriate way to have an estimator insensitive to the spatial axis and we applied it on SAR data acquired over eastern Turkey for the period 2003-2011. Spatial Allan variance allowed us to well characterize noise features, classically found in InSAR such as phase decorrelation producing white noise or atmospheric delays, behaving like a random walk signal. We finally applied the spatial Allan variance to an InSAR time

  6. Myelination Delay and Allan-Herndon-Dudley Syndrome Caused by a Novel Mutation in the SLC16A2 Gene.

    PubMed

    La Piana, Roberta; Vanasse, Michel; Brais, Bernard; Bernard, Genevieve

    2015-09-01

    Allan-Herndon-Dudley syndrome is an X-linked disease caused by mutations in the solute carrier family 16 member 2 (SLC16A2) gene. As SLC16A2 encodes the monocarboxylate transporter 8 (MCT8), a thyroid hormone transporter, patients with Allan-Herndon-Dudley syndrome present a specific altered thyroid hormone profile. Allan-Herndon-Dudley syndrome has been associated with myelination delay on the brain magnetic resonance imaging (MRI) of affected subjects. We report a patient with Allan-Herndon-Dudley syndrome characterized by developmental delay, hypotonia, and delayed myelination caused by a novel SLC16A2 mutation (p.L291R). The thyroid hormones profile in our patient was atypical for Allan-Herndon-Dudley syndrome. The follow-up examinations showed that the progression of the myelination was not accompanied by a clinical improvement. Our paper suggests that SLC16A2 mutations should be investigated in patients with myelination delay even when the thyroid function is not conclusively altered.

  7. Interferometer real time control development for SIM

    NASA Astrophysics Data System (ADS)

    Bell, Charles E.

    2003-02-01

    Real Time Control (RTC) for the Space Interferometry Mission will build on the real time core interferometer control technology under development at JPL since the mid 1990s, with heritage from the ground based MKII and Palomar Testbed Interferometer projects developed in the late '80s and early '90s. The core software and electronics technology for SIM interferometer real time control is successfully operating on several SIM technology demonstration testbeds, including the Real-time Interferometer Control System Testbed, System Testbed-3, and the Microarcsecond Metrology testbed. This paper provides an overview of the architecture, design, integration, and test of the SIM flight interferometer real time control to meet challenging flight system requirements for the high processor throughput, low-latency interconnect, and precise synchronization to support microarcsecond-level astrometric measurements for greater than five years at 1 AU in Earth-trailing orbit. The electronics and software architecture of the interferometer real time control core and its adaptation to a flight design concept are described. Control loops for pointing and pathlength control within each of four flight interferometers and for coordination of control and data across interferometers are illustrated. The nature of onboard data processing to fit average downlink rates while retaining post-processed astrometric measurement precision and accuracy is also addressed. Interferometer flight software will be developed using a software simulation environment incorporating models of the metrology and starlight sensors and actuators to close the real time control loops. RTC flight software and instrument flight electronics will in turn be integrated utilizing the same simulation architecture for metrology and starlight component models to close real time control loops and verify RTC functionality and performance prior to delivery to flight interferometer system integration at Lockheed Martin

  8. The USNO SIM Grid Star Selection Program

    NASA Astrophysics Data System (ADS)

    Mason, B. D.; Corbin, T. E.; Hajian, A. R.; Hummel, C. A.; Rafferty, T. J.; Urban, S. E.; Zacharias, N.

    1999-09-01

    The United States Naval Observatory (USNO) is in the process of preparing an input catalog of SIM grid stars by utilizing existing databases, observing capabilities, and instrumental development. The SIM grid should be astrometrically stable at the 4 mu as level over the five year life of the program, therefore, double and multiple stars must be avoided. Stars in the apparent magnitude range 6.5 < m_v < 8.5 with spectral types from A5V through G5V are being considered. Known doubles have been eliminated, and proper motions will identify previously unknown, wide pairs. This program involves a comprehensive selection and observing program, the first half year of which has seen candidate selection and the start of survey observations with the USNO speckle camera. In later years, further elimination of doubles will be made astrometrically with the Navy Prototype Optical Interferometer and wide-field CCD work. In addition, a Fourier Transform Spectrometer (FTS), with a potential for sub-meter per second radial velocity determinations, is being developed to eliminate companions (both stellar and substellar). In total, 7,200 candidate stars, evenly distributed over the sky will be examined observationally. The combination of the four astrometric methods will remove double and multiple systems in the ~ 15 arcsec to ~ 1 milliarcsecond range with Delta m_v of 3.5 magnitudes, while the FTS is expected to detect companions with masses as low as Saturn in the range of 0.1 to 10 au. The first year of the program has thus far seen significant progress. The SIM grid candidate list has been prepared and speckle observations of these candidates have begun: in the northern hemisphere, by the USNO and the RIT/Yale group (Elliott Horch & Zoran Nikov, Rochester Institute of Technology and William van Altena, Yale).

  9. Rim Sim: A Role-Play Simulation

    USGS Publications Warehouse

    Barrett, Robert C.; Frew, Suzanne L.; Howell, David G.; Karl, Herman A.; Rudin, Emily B.

    2003-01-01

    Rim Sim is a 6-hour, eight-party negotiation that focuses on creating a framework for the long-term disaster-recovery efforts. It involves a range of players from five countries affected by two natural disasters: a typhoon about a year ago and an earthquake about 6 months ago. The players are members of an International Disaster Working Group (IDWG) that has been created by an international commission. The IDWG has been charged with drawing up a framework for managing two issues: the reconstruction of regionally significant infrastructure and the design of a mechanism for allocating funding to each country for reconstruction of local infrastructure and ongoing humanitarian needs. The first issue will involve making choices among five options (two harbor options, two airport options, and one rail-line option), each of which will have three levels at which to rebuild. The second issue will involve five starting-point options. Participants are encouraged to invent other options for both issues. The goal of Rim Sim is to raise questions about traditional approaches to disaster-preparedness planning and reconstruction efforts in an international setting, in this case the Pacific Rim. Players must confront the reverberating effects of disasters and the problems of using science and technical information in decisionmaking, and are introduced to a consensus-building approach emphasizing face-to-face dialog and multinational cooperation in dealing with humanitarian concerns, as well as long-term efforts to reconstruct local and regional infrastructure. The Rim Sim simulation raises four key points: ripple effects of disasters, role of science, multiparty negotiation, and building personal relationships.

  10. QuakeSim 2.0

    NASA Technical Reports Server (NTRS)

    Donnellan, Andrea; Parker, Jay W.; Lyzenga, Gregory A.; Granat, Robert A.; Norton, Charles D.; Rundle, John B.; Pierce, Marlon E.; Fox, Geoffrey C.; McLeod, Dennis; Ludwig, Lisa Grant

    2012-01-01

    QuakeSim 2.0 improves understanding of earthquake processes by providing modeling tools and integrating model applications and various heterogeneous data sources within a Web services environment. QuakeSim is a multisource, synergistic, data-intensive environment for modeling the behavior of earthquake faults individually, and as part of complex interacting systems. Remotely sensed geodetic data products may be explored, compared with faults and landscape features, mined by pattern analysis applications, and integrated with models and pattern analysis applications in a rich Web-based and visualization environment. Integration of heterogeneous data products with pattern informatics tools enables efficient development of models. Federated database components and visualization tools allow rapid exploration of large datasets, while pattern informatics enables identification of subtle, but important, features in large data sets. QuakeSim is valuable for earthquake investigations and modeling in its current state, and also serves as a prototype and nucleus for broader systems under development. The framework provides access to physics-based simulation tools that model the earthquake cycle and related crustal deformation. Spaceborne GPS and Inter ferometric Synthetic Aperture (InSAR) data provide information on near-term crustal deformation, while paleoseismic geologic data provide longerterm information on earthquake fault processes. These data sources are integrated into QuakeSim's QuakeTables database system, and are accessible by users or various model applications. UAVSAR repeat pass interferometry data products are added to the QuakeTables database, and are available through a browseable map interface or Representational State Transfer (REST) interfaces. Model applications can retrieve data from Quake Tables, or from third-party GPS velocity data services; alternatively, users can manually input parameters into the models. Pattern analysis of GPS and seismicity data

  11. Design And Performance Of 20 And 45 GHZ MMIC Lange Couplers

    NASA Astrophysics Data System (ADS)

    Wallace, Jack E.; Ellis, Grant A.

    1988-11-01

    Experimental results are presented for GaAs MMIC Lange coupler designs in both the 15 to 25 GHz and 33 to 50 GHz frequency ranges. Coupler insertion loss, return loss, isolation, and differential insertion phase are included.

  12. Prevalence of autism spectrum phenomenology in Cornelia de Lange and Cri du Chat syndromes.

    PubMed

    Moss, Joanna F; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

    2008-07-01

    Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat syndrome (M ages 12.4 [SD = 3.8] and 10.3 years [SD = 3.6], respectively). Twenty-one participants with Cornelia de Lange syndrome (61.8%) scored above the autism cut-off on the Autism Diagnostic Observation Schedule compared to 9 with Cri du Chat syndrome (39.2%). Prevalence of autism spectrum disorder characteristics is heightened in Cornelia de Lange syndrome. The profile of characteristics is atypical to that of idiopathic autism.

  13. In Praise of Dissidence: Anne Lang-Etienne (1932-1991). Muriel Driver Memorial Lecture.

    ERIC Educational Resources Information Center

    Thibeault, Rachel

    2002-01-01

    Discusses the life and work of Anne Lang-Etienne, a dissident occupational therapist who moved and shaped a generation of Canadian therapists and spurred the profession to action for social change. Includes 18 references. (JOW)

  14. The origin of mélanges: Cautionary tales from Indonesia

    NASA Astrophysics Data System (ADS)

    Barber, A. J.

    2013-10-01

    The origin of block-in-matrix mélanges has been the subject of intense speculation by structural and tectonic geologists working in accretionary complexes since their first recognition in the early twentieth century. Because of their enigmatic nature, a number of important international meetings and a large number of publications have been devoted to the problem of the origin of mélanges. As mélanges show the effects of the disruption of lithological units to form separate blocks, and also apparently show the effects shearing in the scaly fabric of the matrix, a tectonic origin has often been preferred. Then it was suggested that the disruption to form the blocks in mélanges could also occur in a sedimentary environment due to the collapse of submarine fault scarps to form olistostromes, upon which deformation could be superimposed tectonically. Subsequently it has proposed that some mélanges have originated by overpressured clays rising buoyantly towards the surface, incorporating blocks of the overlying rocks in mud or shale diapirs and mud volcanoes. Two well-known examples of mélanges from the Banda and Sunda arcs are described, to which tectonic and sedimentary origins were confidently ascribed, which proved on subsequent examination to have been formed due to mud diapirism, in a dynamically active environment, as the result of tectonism only indirectly. Evidence from the Australian continental Shelf to the south of Sumba shows that large quantities of diapiric mélange were generated before the diapirs were incorporated in the accretionary complex. Comparable diapirs can be recognised in Timor accreted at an earlier stage. Evidence from both Timor and Nias shows that diapiric mélange can be generated well after the initial accretion process was completed. The problem is: Why, when diapirism is so abundantly found in present convergent margins, is it so rarely reported from older orogenic belts? Many occurrences of mélanges throughout the world to

  15. Artist concept of SIM PlanetQuest Artist Concept

    NASA Image and Video Library

    2002-12-21

    Artist's concept of the current mission configuration. SIM PlanetQuest (formerly called Space Interferometry Mission), currently under development, will determine the positions and distances of stars several hundred times more accurately than any previous program. This accuracy will allow SIM to determine the distances to stars throughout the galaxy and to probe nearby stars for Earth-sized planets. SIM will open a window to a new world of discoveries. http://photojournal.jpl.nasa.gov/catalog/PIA04248

  16. Experimental Results for SimFuels

    SciTech Connect

    Buck, Edgar C.; Casella, Andrew M.; Skomurski, Frances N.; MacFarlan, Paul J.; Soderquist, Chuck Z.; Wittman, Richard S.; Mcnamara, Bruce K.

    2012-08-22

    Assessing the performance of Spent (or Used) Nuclear Fuel (UNF) in geological repository requires quantification of time-dependent phenomena that may influence its behavior on a time-scale up to millions of years. A high-level waste repository environment will be a dynamic redox system because of the time-dependent generation of radiolytic oxidants and reductants and the corrosion of Fe-bearing canister materials. One major difference between used fuel and natural analogues, including unirradiated UO2, is the intense radiolytic field. The radiation emitted by used fuel can produce radiolysis products in the presence of water vapor or a thin-film of water that may increase the waste form degradation rate and change radionuclide behavior. To study UNF, we have been working on producing synthetic UO2 ceramics, or SimFuels that can be used in testing and which will contain specific radionuclides or non-radioactive analogs so that we can test the impact of radiolysis on fuel corrosion without using actual spent fuel. Although, testing actual UNF would be ideal for understanding the long term behavior of UNF, it requires the use of hot cells and is extremely expensive. In this report, we discuss, factors influencing the preparation of SimFuels and the requirements for dopants to mimic the behavior of UNF. We have developed a reliable procedure for producing large grain UO2 at moderate temperatures. This process will be applied to a series of different formulations.

  17. SIMS and TEM Analysis of Niobium Bicrystals

    SciTech Connect

    Maheshwari, P; Griffis, D P; Stevie, F A; Zhou, C; Ciovati, G; Myneni, R; Spradlin, J K; Rigsbee, M

    2011-07-01

    The behaviour of interstitial impurities(C,O,N,H) on the Nb surface with respect to grain boundaries may affect cavity performance. Large grain Nb makes possible the selection of bicrystal samples with a well defined grain boundary. In this work, Dynamic SIMS was used to analyze two Nb bicrystal samples, one of them heat treated and the other non heat treated (control). H levels were found to be higher for the non heat treated sample and a difference in the H intensity and sputtering rate was also observed across the grain boundary for both the samples. TEM results showed that the bicrystal interface showed no discontinuity and the oxide layer was uniform across the grain boundary for both the samples. TOF-SIMS imaging was also performed to analyze the distribution of the impurities across the grain boundary in both the samples. C was observed to be segregated along the grain boundary for the control sample, while H and O showed a difference in signal intensity across the grain boundary. Crystal orientation appears to have an important role in the observed sputtering rate and impurity ion signal differences both across the grain boundary and between samples

  18. Coherent scatter implementation for SimSET

    NASA Astrophysics Data System (ADS)

    Kaplan, M. S.; Harrison, R. L.; Vannoy, S. D.

    1998-12-01

    At 140 keV, 3% of photon scatter interactions in human tissues are coherent scatter; at Tl-201 emission energies, this fraction increases to approximately 7%. However, since coherent scatter at these energies is sharply forward-peaked, it is often the dominant scatter interaction at small angles. SimSET (Simulation System for Emission Tomography), which previously modeled only photoelectric absorption and Compton scatter, has been extended to include coherent scatter. The current implementation uses form factor and anomalous scattering amplitude data from the Livermore Evaluated Photon Data Library. Interaction probability and angular distribution tables for several human tissues and common detector materials were calculated using the independent atoms approximation and human-tissue composition data from the ICRP Reference Man. These data were also used to generate new tables for photoelectric absorption and Compton scatter, significantly improving the accuracy of SimSET and extending its photon tracking capability to lower photon energy (from 50 keV to 1 keV). The form, content, and structure of the tables were carefully designed for efficient data storage, access, and use by the software. The derived data tables and implementation of coherent scatter were validated by comparing simulation results to published differential cross-section data.

  19. Jamming of granular ice mélange in tidewater glacial fjords

    NASA Astrophysics Data System (ADS)

    Burton, J. C.; Cassotto, R.; Amundson, J. M.; Kuo, C. C.; Dennin, M.

    2016-12-01

    In tidewater glacial fjords, the open water in front of the glacier terminus is often filled with a collection of calved iceberg fragments and sea ice. For glaciers with large calving rates, this "mélange" of ice can be jam-packed, so that the flow is mostly determined by granular interactions, in addition to underlying fjord currents. As the glacier pushes the ice mélange through the fjord, the mélange will become jammed and may potentially influence calving rates if the back-stress applied to the glacier terminus is large enough. However, the stress applied by a granular ice mélange will depend on its rheology, i.e. iceberg-iceberg contact forces, geometry, friction, etc. Here we report 2D, discrete particle simulations to model the granular mechanics of ice mélange. A polydisperse collection of particles is packed into a long channel and pushed downfjord at a constant speed, the latter derived from terrestrial radar interferometry (TRI). Each individual particle experiences viscoelastic contact forces and tangential frictional forces upon collision with another particle or channel walls. We find the two most important factors that govern the total force applied to the glacier are the geometry of the channel, and the shape of the particles. In addition, our simulated velocity fields reveal shearing margins near the fjord walls with more uniform flow in the middle of the mélange, consistent with TRI observations. Finally, we find that the magnitude of the back-stress applied to the glacier terminus can influence calving, however, the maximum back-stress is limited by the buckling of icebergs into the fjord waters, so that the stress in the quasi-2D mélange is partially determined by the thickness of the mélange layer.

  20. The origin and tectonic significance of mélanges in Eastern Sabah, Malaysia

    NASA Astrophysics Data System (ADS)

    Clennell, Ben

    Extensive chaotically disrupted rock bodies are found across Sabah in diverse tectonic settings. These units, which include broken formations, a dismembered arc-ophiolite complex and mud-matrix mélanges were formed by a combination of sedimentary, tectonic and diapiric processes. The mélanges of the eastern part of Sabah are considered to be related to basin initiation in an intra-arc setting, and are not related directly to subduction-accretion processes. The East Sabah mélanges are composed predominantly of deep water clastic sediments, deposited in the Central Sabah Basin, mixed with varying amounts of exotic ophiolitic material. The sedimentary clasts have a variety of well-developed "soft-sediment" deformation structures. These are in part inherited into the mélange from syn-sedimentary deformation, and in part generated during the mélange-forming events. The mélanges are not metamorphosed, and vitrinite reflectance data suggest that except for a few localities, a maximum temperature of less than 120°C was attained in the matrix. The ophiolitic blocks commonly have tectonic shearing fabrics associated with low temperature metamorphism. These metamorphic fabrics are incompatible with the deformation mechanisms in the sedimentary clasts and the mud matrix, and are interpreted as being inherited from shear in the ocean floor environment (e.g. fracture zones) or associated with ophiolite obduction. The similarity in clast type, deformation history and general structure also suggest that all the mélanges of the east of Sabah were formed in a series of related events during late Early Miocene and earliest Middle Miocene time. It is postulated that these events, which triggered sedimentary, diapiric and tectonic mélange-forming processes, are related to the coeval onset of extension and sea floor spreading in the southeastern Sulu Sea.

  1. [Ophthalmological manifestations of Cornelia de Lange syndrome: Case report and review of the literature].

    PubMed

    Avgitidou, G; Cursiefen, C; Heindl, L M

    2015-05-01

    A 2-year-old boy suffering from Cornelia de Lange syndrome, presented with mucopurulent ocular discharge and epiphora since birth. Irrigation and probing of the nasolacrimal system revealed and successfully treated bilateral nasolacrimal duct obstructions. Cornelia de Lange syndrome is characterized not only by typical facial features, visceral and urogenital anomalies but also by ophthalmological manifestations in 99% of cases. The most common ophthalmological disorders are synophrys, blepharitis, epiphora, hypertrichosis of the eyebrows and eyelashes, myopia, ptosis and nasolacrimal duct obstruction.

  2. Noble gases in twenty Yamato H-chondrites: Comparison with Allan Hills chondrites and modern falls

    NASA Technical Reports Server (NTRS)

    Loeken, TH.; Scherer, P.; Schultz, L.

    1993-01-01

    Concentration and isotopic composition of noble gases have been measured in 20 H-chrondrites found on the Yamato Mountains ice fields in Antarctica. The distribution of exposure ages as well as of radiogenic He-4 contents is similar to that of H-chrondrites collected at the Allan Hills site. Furthermore, a comparison of the noble gas record of Antarctic H-chrondrites and finds or falls from non-Antarctic areas gives no support to the suggestion that Antarctic H-chrondrites and modern falls derive from differing interplanetary meteorite populations.

  3. The discovery and initial characterization of Allan Hills 81005 - The first lunar meteorite

    NASA Technical Reports Server (NTRS)

    Marvin, U. B.

    1983-01-01

    Antarctic meteorite ALHA81005, discovered in the Allan Hills region of Victoria Land, is a polymict anorthositic breccia which differs from other meteorites in mineralogical and chemical composition but is strikingly similar to lunar highlands soil breccias. The petrologic character and several independent lines of evidence identify ALHA81005 as a meteorite from the moon. Two small clasts of probable mare basalt occur among the highlands lithologies in Thin Section 81005,22. This lunar specimen, which shows relatively minor shock effects, has generated new ideas on the types of planetary samples found on the earth.

  4. Allan C. Gotlib, DC, CM: A worthy Member of the Order of Canada

    PubMed Central

    Brown, Douglas M.

    2016-01-01

    On June 29, 2012, His Excellency the Right Honourable David Johnston, Governor General of Canada, announced 70 new appointments to the Order of Canada. Among them was Dr. Allan Gotlib, who was subsequently installed as a Member of the Order of Canada, in recognition of his contributions to advancing research in the chiropractic profession and its inter-professional integration. This paper attempts an objective view of his career, to substantiate the accomplishments that led to Dr. Gotlib receiving Canada’s highest civilian honour. PMID:27069273

  5. Investigation of Allan variance for determining noise spectral forms with application to microwave radiometry

    NASA Technical Reports Server (NTRS)

    Stanley, William D.

    1994-01-01

    An investigation of the Allan variance method as a possible means for characterizing fluctuations in radiometric noise diodes has been performed. The goal is to separate fluctuation components into white noise, flicker noise, and random-walk noise. The primary means is by discrete-time processing, and the study focused primarily on the digital processes involved. Noise satisfying the requirements was generated by direct convolution, fast Fourier transformation (FFT) processing in the time domain, and FFT processing in the frequency domain. Some of the numerous results obtained are presented along with the programs used in the study.

  6. Special cases in Cornelia de Lange syndrome: The Spanish experience.

    PubMed

    Pié, Juan; Puisac, Beatriz; Hernández-Marcos, Maria; Teresa-Rodrigo, Maria Esperanza; Gil-Rodríguez, Maria; Baquero-Montoya, Carolina; Ramos-Cáceres, Maria; Bernal, Maria; Ayerza-Casas, Ariadna; Bueno, Inés; Gómez-Puertas, Paulino; Ramos, Feliciano J

    2016-06-01

    Cornelia de Lange Syndrome (CdLS) is an autosomal dominant (NIPBL, SMC3, and RAD21) or X-linked (SMC1A and HDAC8) disorder, characterized by distinctive craniofacial appearance, growth retardation, intellectual disability, and limb anomalies. In 2005, the Spanish CdLS Reference Center was started and now we have more than 270 cases in our database. In this special issue, we describe some of the unique or atypical patients studied by our group, whose clinical features have contributed to the expansion of the CdLS classical phenotype, helping clinicians to diagnose it. We include the case of a male with unilateral tibial hypoplasia and peroneal agenesis who had a mutation in NIPBL; we also describe one patient with a mutation in NIPBL and somatic mosaicism identified by new generation sequencing techniques; we also include one patient with CdLS and Turner syndrome; and last, an interesting patient with a duplication of the SMC1A gene. Finally, we make a short review of the splicing mutations we have found in NIPBL regarding the new knowledge on the physiological variants of the gene. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Behaviour in Cornelia de Lange syndrome: a systematic review.

    PubMed

    Mulder, Paul A; Huisman, Sylvia A; Hennekam, Raoul C; Oliver, Chris; van Balkom, Ingrid D C; Piening, Sigrid

    2017-04-01

    Careful study and accurate description of behaviour are important to understand developmental challenges for individuals with Cornelia de Lange syndrome (CdLS). Here we present a systematic review of current understanding of behaviour in CdLS. A systematic search was performed for articles published between January 1946 and December 2015 evaluating autism, self-injury, and/or cognition in CdLS. After study-selection, 43 papers were included. The Cochrane quality criteria were adjusted to assign quality scores to the included studies. Participants were mostly categorized in the severe/profound developmental level. Methodology and quality were very heterogeneous, as well as reporting occurrence of autism. Self-injurious behaviour was reported in 15 papers. Physical conditions were reported in 21 studies, mostly related to hearing and vision. Only nine studies mentioned details about medication. Comparison of presented results was hindered by heterogeneous assessment methods. Improving our understanding of behavioural characteristics in CdLS requires more uniform methodology. We propose a criterion standard of instruments that can ideally be used in assessment of behaviour and development. This will improve understanding of behaviour in the context of developmental level and daily functioning. © 2016 Mac Keith Press.

  8. Precocious Sister Chromatid Separation (PSCS) in Cornelia de Lange Syndrome

    PubMed Central

    Kaur, Maninder; DeScipio, Cheryl; McCallum, Jennifer; Yaeger, Dinah; Devoto, Marcella; Jackson, Laird G.; Spinner, Nancy B.; Krantz, Ian D.

    2009-01-01

    The Cornelia de Lange syndrome (CdLS) (OMIM# 122470) is a dominantly inherited multisystem developmental disorder. The phenotype consists of characteristic facial features, hirsutism, abnormalities of the upper extremities ranging from subtle changes in the phalanges and metacarpal bones to oligodactyly and phocomelia, gastroesophageal dysfunction, growth retardation, and neurodevelopmental delay. Prevalence is estimated to be as high as 1 in 10,000. Recently, mutations in NIPBL were identified in sporadic and familial CdLS cases. To date, mutations in this gene have been identified in over 45% of individuals with CdLS. NIPBL is the human homolog of the Drosophila Nipped-B gene. Although its function in mammalian systems has not yet been elucidated, sequence homologs of Nipped-B in yeast (Scc2 and Mis4) are required for sister chromatid cohesion during mitosis, and a similar role was recently demonstrated for Nipped-B in Drosophila. In order to evaluate NIPBL role in sister chromatid cohesion in humans, metaphase spreads on 90 probands (40 NIPBL mutation positive and 50 NIPBL mutation negative) with CdLS were evaluated for evidence of precocious sister chromatid separation (PSCS). We screened 50 metaphases from each proband and found evidence of PSCS in 41% (compared to 9% in control samples). These studies indicate that NIPBL may play a role in sister chromatid cohesion in humans as has been reported for its homologs in Drosophila and yeast. PMID:16100726

  9. Behavioral and psychiatric manifestations in Cornelia de Lange syndrome.

    PubMed

    Grados, Marco A; Alvi, Mustafa H; Srivastava, Siddharth

    2017-03-01

    Cornelia de Lange syndrome (CdLS) is a rare genetic syndrome with clinical manifestations due to multiple affected organ systems including limbs, gastrointestinal, skin, and central nervous systems. Although the genetic basis of CdLS is now uncovered, how behavioral manifestations are associated with genetic and brain differences are less well understood. The current focused review systematically describes the main behavioral observations to date in individuals with CdLS, which have a significant impact on quality of life and adaptive functioning. The CdLS behavioral phenotype includes autistic traits as a prominent feature; however, brain imaging studies, required to understand gene-brain-behavior connections in CdLS, are scarce. Moreover, autistic features in CdLS have a greater emphasis on repetitive behaviors, including self-injurious behaviors (SIB) and expressive communication deficits, different that the core social deficit seen in idiopathic autism. Current data strongly support the use of CdLS as a model disease for repetitive behaviors and associated developmental delay manifestations. Behavioral phenotype characteristics in CdLS point to a preponderance of repetitive clinical phenomena as well as expressive verbal deficits that ought to inform specific treatment approaches in CdLS. In particular, repetitive behaviors associated with self-injury are of high negative impact on the quality of life for individuals with CdLS and their families. Treatment approaches geared to manage repetitive behaviors and self-injurious behaviors in CdLS are required in this developmental condition.

  10. Clinical Report: Germline Mosaicism in Cornelia de Lange Syndrome

    PubMed Central

    Slavin, Thomas P.; Lazebnik, Noam; Clark, Dinah M.; Vengoechea, Jaime; Cohen, Leslie; Kaur, Maninder; Konczal, Laura; Crowe, Carol A.; Corteville, Jane E.; Nowaczyk, Malgorzata J.; Byrne, Janice L.; Jackson, Laird G.; Krantz, Ian D.

    2012-01-01

    Cornelia de Lange syndrome (CdLS) is a genetic disorder associated with delayed growth, intellectual disability, limb reduction defects and characteristic facial features. Germline mosaicism has been a described mechanism for CdLS when there are several affected offspring of apparently unaffected parents. Presently, the recurrence risk for CdLS has been estimated to be as high as 1.5%; however, this figure may be an underrepresentation. We report on the molecularly defined germline mosaicism cases from a large CdLS database, representing the first large case series on germline mosaicism in CdLS. Of the 12 families, eight have been previously described; however, four have not. No one specific gene mutation, either in the NIPBL or the SMC1A gene, was associated with an increased risk for germline mosaicism. Suspected or confirmed cases of germline mosaicism in our database range from a conservative 3.4% up to 5.4% of our total cohort. In conclusion, the potential reproductive recurrence risk due to germline mosiacism should be addressed in prenatal counseling for all families who have had a previously affected pregnancy or child with CdLS. PMID:22581668

  11. Successful Growth Hormone Therapy in Cornelia de Lange Syndrome.

    PubMed

    de Graaf, Michael; Kant, Sarina G; Wit, Jan Maarten; Willem Redeker, Egbert Johan; Eduard Santen, Gijs Willem; Henriëtta Verkerk, Annemieke Johanna Maria; Uitterlinden, André Gerardus; Losekoot, Monique; Oostdijk, Wilma

    2017-06-07

    Cornelia de Lange Syndrome (CdLS) is a heterogeneous syndrome, both clinically and genetically, in its classical form characterised by distinctive facial features, intra-uterine growth retardation, short stature, developmental delay and anomalies in multiple organ systems. NIPBL, SMC1A, SMC3, RAD21 and HDAC8, all involved in the Cohesin pathway, have been identified to cause CdLS. Growth hormone (GH) secretion has been reported as normal, and to our knowledge there are no reports on the effect of recombinant human GH (r-hGH) treatment in CdLS patients. We present a patient born small for gestational age (SGA) with persistent severe growth retardation (height -3.4 SDS) and mild dysmorphic features, who was treated with GH from 4.3 years of age onward, and diagnosed 6 years later with CdLS using whole exome sequencing. Treatment led to a height gain of 1.6 standard deviation score (SDS) over 8 years. Treatment was interrupted shortly due to high serum IGF-1 serum values. We conclude that GH therapy appears effective and safe for short children with CdLS.

  12. Cornelia de Lange syndrome: Congenital heart disease in 149 patients.

    PubMed

    Ayerza Casas, Ariadna; Puisac Uriol, Beatriz; Teresa Rodrigo, María Esperanza; Hernández Marcos, María; Ramos Fuentes, Feliciano J; Pie Juste, Juan

    2017-10-11

    Cornelia de Lange syndrome (CdLS) is produced by mutations in genes that encode regulatory or structural proteins of the cohesin complex. Congenital heart disease (CHD) is not a major criterion of the disease, but it affects many individuals. The objective of this study was to study the incidence and type of CHD in patients with CdLS. Cardiological findings were evaluated in 149 patients with CdLS and their possible relationship with clinical and genetic variables. A percentage of 34.9 had CHD (septal defects 50%, pulmonary stenosis 27%, aortic coarctation 9.6%). The presence of CHD was related with neonatal hospitalisation (P=.04), hearing loss (P=.002), mortality (P=.09) and lower hyperactivity (P=.02), it being more frequent in HDAC8+ patients (60%), followed by NIPBL+ (33%) and SMC1A+ (28.5%). While septal defects predominate in NIPBL+, pulmonary stenosis is more common in HDAC8+. Patients with CdLS have a high incidence of CHD, which varies according to the affected gene, the most frequent findings being septal defects and pulmonary stenosis. Perform a cardiologic study in all these patients is suggested. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  13. The natural thermoluminescence of meteorites. V - Ordinary chondrites at the Allan Hills ice fields

    NASA Technical Reports Server (NTRS)

    Benoit, Paul H.; Sears, Hazel; Sears, Derek W. G.

    1993-01-01

    Natural thermoluminescence (TL) data have been obtained for 167 ordinary chondrites from the ice fields in the vicinity of the Allan Hills in Victoria Land, Antarctica, in order to investigate their thermal and radiation history, pairing, terrestrial age, and concentration mechanisms. Natural TL values for meteorites from the Main ice field are fairly low, while the Farwestern field shows a spread with many values 30-80 krad, suggestive of less than 150-ka terrestrial ages. There appear to be trends in TL levels within individual ice fields which are suggestive of directions of ice movement at these sites during the period of meteorite concentration. These directions seem to be confirmed by the orientations of elongation preserved in meteorite pairing groups. The proportion of meteorites with very low natural TL levels at each field is comparable to that observed at the Lewis Cliff site and for modern non-Antarctic falls and is also similar to the fraction of small perihelia orbits calculated from fireball and fall observations. Induced TL data for meteorites from the Allan Hills confirm trends which show that a select group of H chondrites from the Antarctic experienced a different extraterrestrial thermal history to that of non-Antarctic H chondrites.

  14. The natural thermoluminescence of meteorites. V - Ordinary chondrites at the Allan Hills ice fields

    NASA Technical Reports Server (NTRS)

    Benoit, Paul H.; Sears, Hazel; Sears, Derek W. G.

    1993-01-01

    Natural thermoluminescence (TL) data have been obtained for 167 ordinary chondrites from the ice fields in the vicinity of the Allan Hills in Victoria Land, Antarctica, in order to investigate their thermal and radiation history, pairing, terrestrial age, and concentration mechanisms. Natural TL values for meteorites from the Main ice field are fairly low, while the Farwestern field shows a spread with many values 30-80 krad, suggestive of less than 150-ka terrestrial ages. There appear to be trends in TL levels within individual ice fields which are suggestive of directions of ice movement at these sites during the period of meteorite concentration. These directions seem to be confirmed by the orientations of elongation preserved in meteorite pairing groups. The proportion of meteorites with very low natural TL levels at each field is comparable to that observed at the Lewis Cliff site and for modern non-Antarctic falls and is also similar to the fraction of small perihelia orbits calculated from fireball and fall observations. Induced TL data for meteorites from the Allan Hills confirm trends which show that a select group of H chondrites from the Antarctic experienced a different extraterrestrial thermal history to that of non-Antarctic H chondrites.

  15. RFI-SIM: RFI Simulation Package

    NASA Technical Reports Server (NTRS)

    Ghaemi, Hirad; Chen, Curtis W.

    2013-01-01

    RFI-SIM simulates the RFI environment to estimate the interference from terrestrial emitters into spacecraft, or vice versa. A high-fidelity simulation of the RFI environment has been developed by employing all antenna- related and radar system-related parameters of multiple emitters, as well as that of the desired spacecraft. In the simulation, the real-time analysis of the interference and its effects on error budgets of a desired radar system is taken into account. This provides a reliable tool for radar system design to deal with RFI issues and to evaluate the sensitivity of various parts of a radar system including antenna pattern, RF front-end and digital processing to RFI signals.

  16. Tracking microbial interactions with NanoSIMS

    SciTech Connect

    Musat, Niculina; Musat, Florin; Weber, Peter Kilian; Pett-Ridge, Jennifer

    2016-10-01

    The combination of stable isotope probing (SIP), NanoSIMS imaging and microbe identification via fluorescence in situ hybridization (FISH) is often used to link identity to function at the cellular level in microbial communities. Many opportunities remain for nanoSIP to identify metabolic interactions and nutrient fluxes within syntrophic associations and obligate symbioses where exchanges can be extremely rapid. However, additional data, such as genomic potential, gene expression or other imaging modalities are often critical to deciphering the mechanisms underlying specific interactions, and researchers must keep sample preparation artefacts in mind. Here we focus on recent applications of nanoSIP, particularly where used to track exchanges of isotopically labelled molecules between organisms. We highlight metabolic interactions within syntrophic consortia, carbon/nitrogen fluxes between phototrophs and their heterotrophic partners, and symbiont–host nutrient sharing.

  17. SIMS depth profiling of working environment nanoparticles

    NASA Astrophysics Data System (ADS)

    Konarski, P.; Iwanejko, I.; Mierzejewska, A.

    2003-01-01

    Morphology of working environment nanoparticles was analyzed using sample rotation technique in secondary ion mass spectrometry (SIMS). The particles were collected with nine-stage vacuum impactor during gas tungsten arc welding (GTAW) process of stainless steel and shielded metal arc welding (SMAW) of mild steel. Ion erosion of 300-400 nm diameter nanoparticles attached to indium substrate was performed with 2 keV, 100 μm diameter, Ar + ion beam at 45° ion incidence and 1 rpm sample rotation. The results show that both types of particles have core-shell morphology. A layer of fluorine, chlorine and carbon containing compounds covers stainless steel welding fume particles. The cores of these particles are enriched in iron, manganese and chromium. Outer shell of mild steel welding fume particles is enriched in carbon, potassium, chlorine and fluorine, while the deeper layers of these nanoparticles are richer in main steel components.

  18. SimITK: model driven engineering for medical imaging

    NASA Astrophysics Data System (ADS)

    Trezise, Melissa; Gobbi, David; Cordy, James; Abolmaesumi, Purang; Mousavi, Parvin

    2014-03-01

    The Insight Segmentation and Registration Toolkit (ITK) is a highly utilized open source medical imaging library providing chiefly the functionality to register, segment, and filter medical images. Although extremely powerful, ITK has a steep learning curve for users with little or no background in programming. It was for this reason that SimITK was developed. SimITK wraps ITK into the model driven engineering environment Simulink, a part of the Matlab development suite. The first released version of SimITK was a proof of concept, and demonstrated that ITK could be wrapped successfully in Simulink. In this paper a new version of SimITK is presented where ITK classes are wrapped using a fully automated process. In addition, SimITK is transitioned to successfully support ITK version 4, in order to remain current with the ITK project. SimITK includes thirty-seven image filters, twelve optimizers, and nineteen transform classes from ITK version 4 which are successfully wrapped and tested, and can be quickly and easily combined to perform medical imaging tasks. These classes were chosen to represent a broad range of usability, and to allow for greater flexibility when creating registration pipelines. SimITK has the potential to reduce the learning curve for ITK and allow the user to focus on developing workflows and algorithms. A release of SimITK along with tutorials and videos is available at www.simitkvtk.com.

  19. Services Information Management System (SIMS) Users’ Handbook.

    DTIC Science & Technology

    1987-04-01

    The Services Information Management System (SIMS) Users’ Handbook was prepared to assist the Air Force Engineering and Services Center (AFESC) to...overview of SIMS philosophy and operational concepts to ease the transition to automated information management in the Services business. The areas

  20. Biochemical imaging of tissues by SIMS for biomedical applications

    NASA Astrophysics Data System (ADS)

    Lee, Tae Geol; Park, Ji-Won; Shon, Hyun Kyong; Moon, Dae Won; Choi, Won Woo; Li, Kapsok; Chung, Jin Ho

    2008-12-01

    With the development of optimal surface cleaning techniques by cluster ion beam sputtering, certain applications of SIMS for analyzing cells and tissues have been actively investigated. For this report, we collaborated with bio-medical scientists to study bio-SIMS analyses of skin and cancer tissues for biomedical diagnostics. We pay close attention to the setting up of a routine procedure for preparing tissue specimens and treating the surface before obtaining the bio-SIMS data. Bio-SIMS was used to study two biosystems, skin tissues for understanding the effects of photoaging and colon cancer tissues for insight into the development of new cancer diagnostics for cancer. Time-of-flight SIMS imaging measurements were taken after surface cleaning with cluster ion bombardment by Bi n or C 60 under varying conditions. The imaging capability of bio-SIMS with a spatial resolution of a few microns combined with principal component analysis reveal biologically meaningful information, but the lack of high molecular weight peaks even with cluster ion bombardment was a problem. This, among other problems, shows that discourse with biologists and medical doctors are critical to glean any meaningful information from SIMS mass spectrometric and imaging data. For SIMS to be accepted as a routine, daily analysis tool in biomedical laboratories, various practical sample handling methodology such as surface matrix treatment, including nano-metal particles and metal coating, in addition to cluster sputtering, should be studied.

  1. Binding properties of SUMO-interacting motifs (SIMs) in yeast.

    PubMed

    Jardin, Christophe; Horn, Anselm H C; Sticht, Heinrich

    2015-03-01

    Small ubiquitin-like modifier (SUMO) conjugation and interaction play an essential role in many cellular processes. A large number of yeast proteins is known to interact non-covalently with SUMO via short SUMO-interacting motifs (SIMs), but the structural details of this interaction are yet poorly characterized. In the present work, sequence analysis of a large dataset of 148 yeast SIMs revealed the existence of a hydrophobic core binding motif and a preference for acidic residues either within or adjacent to the core motif. Thus the sequence properties of yeast SIMs are highly similar to those described for human. Molecular dynamics simulations were performed to investigate the binding preferences for four representative SIM peptides differing in the number and distribution of acidic residues. Furthermore, the relative stability of two previously observed alternative binding orientations (parallel, antiparallel) was assessed. For all SIMs investigated, the antiparallel binding mode remained stable in the simulations and the SIMs were tightly bound via their hydrophobic core residues supplemented by polar interactions of the acidic residues. In contrary, the stability of the parallel binding mode is more dependent on the sequence features of the SIM motif like the number and position of acidic residues or the presence of additional adjacent interaction motifs. This information should be helpful to enhance the prediction of SIMs and their binding properties in different organisms to facilitate the reconstruction of the SUMO interactome.

  2. SIM regional comparison of ac-dc current transfer difference SIM.EM-K12

    NASA Astrophysics Data System (ADS)

    Di Lillo, Lucas

    2015-01-01

    The ac-dc current transfer difference identified as SIM.EM.K-12 began in July 2010 and was completed in September 2012. Six NMIs in the SIM region and one NMI in the AFRIMET region took part: NRC (Canada), NIST (United States of America), CENAM (Mexico), INTI (Argentina), UTE (Uruguay), INMETRO (Brazil) and NIS (Egypt). The comparisons were proposed to assess the measurement capabilities in ac-dc current transfer difference of the participants NMIs. The ac-dc current transfer differences of the travelling standard had been measured at 10 mA and 5 A at 10 Hz, 55 Hz, 1 kHz, 10 kHz, 20 kHz, 50 kHz and 100 kHz. The test points were selected to link the results with the equivalent CCEM Key Comparisons (CCEM-K12), through three NMIs participating in both SIM and CCEM key comparisons (INTI, NRC and NIST). The report shows the degree of equivalence in the SIM region and also the degree of equivalence with the corresponding CCEM reference value. The results of all participants support the values and uncertainties of the applicable CMC entries for ac-dc current transfer difference in the Key Comparison Database held at the BIPM. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  3. Unusual association of non-anaplastic Wilms tumor and Cornelia de Lange syndrome: case report.

    PubMed

    Santoro, Claudia; Apicella, Andrea; Casale, Fiorina; La Manna, Angela; Di Martino, Martina; Di Pinto, Daniela; Indolfi, Cristiana; Perrotta, Silverio

    2016-06-13

    Cornelia de Lange syndrome is the prototype for cohesinopathy disorders, which are characterized by defects in chromosome segregation. Kidney malformations, including nephrogenic rests, are common in Cornelia de Lange syndrome. Only one post-mortem case report has described an association between Wilms tumor and Cornelia de Lange syndrome. Here, we describe the first case of a living child with both diseases. Non-anaplastic triphasic nephroblastoma was diagnosed in a patient carrying a not yet reported mutation in NIPBL (c.4920 G > A). The patient had the typical facial appearance and intellectual disability associated with Cornelia de Lange syndrome in absence of limb involvement. The child's kidneys were examined by ultrasound at 2 years of age to exclude kidney abnormalities associated with the syndrome. She underwent pre-operative chemotherapy and nephrectomy. Seven months later she was healthy and without residual detectable disease. The previous report of such co-occurrence, together with our report and previous reports of nephrogenic rests, led us to wonder if there may be any causal relationship between these two rare entities. The wingless/integrated (Wnt) pathway, which is implicated in kidney development, is constitutively activated in approximately 15-20 % of all non-anaplastic Wilms tumors. Interestingly, the Wnt pathway was recently found to be perturbed in a zebrafish model of Cornelia de Lange syndrome. Mutations in cohesin complex genes and regulators have also been identified in several types of cancers. On the other hand, there is no clear evidence of an increased risk of cancer in Cornelia de Lange syndrome, and no other similar cases have been published since the fist one reported by Cohen, and this prompts to think Wilms tumor and Cornelia de Lange syndrome occurred together in our patient by chance.

  4. SimTool - An object based approach to simulation construction

    NASA Technical Reports Server (NTRS)

    Crues, Edwin Z.; Yazbeck, Marwan E.; Edwards, H. C.; Barnette, Randall D.

    1993-01-01

    The creation and maintenance of large complex simulations can be a difficult and error prone task. A number of interactive and automated tools have been developed to aid in simulation construction and maintenance. Many of these tools are based upon object oriented analysis and design concepts. One such tool, SimTool, is an object based integrated tool set for the development, maintenance, and operation of large, complex and long lived simulations. This paper discusses SimTool's object based approach to simulation design, construction and execution. It also discusses the services provided to various levels of SimTool users to assist them in a wide range of simulation tasks. Also, with the aid of an implemented and working simulation example, this paper discusses SimTool's key design and operational features. Finally, this paper presents a condensed discussion of SimTool's Entity-Relationship-Attribute (ERA) modeling approach.

  5. The role of SIMS in cultural heritage studies

    NASA Astrophysics Data System (ADS)

    Dowsett, Mark; Adriaens, Annemie

    2004-11-01

    Secondary ion mass spectrometry (SIMS) is a highly sensitive chemical analysis technique available in variants, which are top monolayer specific (static SIMS) or which can extract micro-volume analyses or depth profiles (dynamic SIMS). The technique offers ppm or even ppb atomic sensitivity for the consumption of extremely small sample volumes. In the area of cultural heritage, SIMS has been applied to a diverse range of problems including technology and authenticity, origin and provenance, degradation processes, such as corrosion and weathering, and conservation. In this paper, the basic attributes and limitations of the technique are described. An outline is given of applications to glasses (obsidian dating, conservation of stained glass and Venetian glass), metals (simulated archaeological bronzes), pigments and human remains, focusing on conservation problems such as the assessment and suppression of corrosion, other degrading processes, identification of materials using speciation. The topic of ultra low energy SIMS, newly applied to cultural heritage materials, is briefly described.

  6. Natural History of Aging in Cornelia de Lange Syndrome

    PubMed Central

    KLINE, ANTONIE D.; GRADOS, MARCO; SPONSELLER, PAUL; LEVY, HOWARD P.; BLAGOWIDOW, NATALIE; SCHOEDEL, CHRISTIANNE; RAMPOLLA, JONI; CLEMENS, DOUGLAS K.; KRANTZ, IAN; KIMBALL, AMY; PICHARD, CARMEN; TUCHMAN, DAVID

    2016-01-01

    Observations about the natural history of aging in Cornelia de Lange syndrome (CdLS) are made, based on 49 patients from a multidisciplinary clinic for adolescents and adults. The mean age was 17 years. Although most patients remain small, obesity may develop. Gastroesophageal reflux persists or worsens, and there are early long-term sequelae, including Barrett esophagus in 10%; other gastrointestinal findings include risk for volvulus, rumination, and chronic constipation. Submucous cleft palate was found in 14%, most undetected before our evaluation. Chronic sinusitis was noted in 39%, often with nasal polyps. Blepharitis improves with age; cataracts and detached retina may occur. Decreased bone density is observed, with occasional fractures. One quarter have leg length discrepancy and 39% scoliosis. Most females have delayed or irregular menses but normal gynecologic exams and pap smears. Benign prostatic hypertrophy occurred in one male prior to 40 years. The phenotype is variable, but there is a distinct pattern of facial changes with aging. Premature gray hair is frequent; two patients had cutis verticis gyrata. Behavioral issues and specific psychiatric diagnoses, including self-injury, anxiety, attention-deficit disorder, autistic features, depression, and obsessive-compulsive behavior, often worsen with age. This work presents some evidence for accelerated aging in CdLS. Of 53% with mutation analysis, 55% demonstrate a detectable mutation in NIPBL or SMC1A. Although no specific genotype–phenotype correlations have been firmly established, individuals with missense mutations in NIPBL and SMC1A appear milder than those with other mutations. Based on these observations, recommendations for clinical management of adults with CdLS are made. PMID:17640042

  7. Onomastic Mirroring: "The Closing of the American Mind" by Allan Bloom and "Lives on the Boundary" by Mike Rose.

    ERIC Educational Resources Information Center

    Heit, Karl

    Although Allan Bloom in "The Closing of the American Mind" and Mike Rose in "Lives on the Boundary" reveal an almost endless list of obvious differences of perspective on literacy and higher education in America, both take divergent yet similar routes to create a permanent place for liberal education. Both Bloom and Rose use…

  8. Flow behavior of ice mélange modeled at the laboratory-scale

    NASA Astrophysics Data System (ADS)

    Kuo, C. C.; Amundson, J. M.; Cassotto, R.; Burton, J. C.; Dennin, M.

    2016-12-01

    Ice mélange, composed of icebergs from iceberg calving and sea ice, is a large-scale, quasi-two dimensional granular system that may affect glacier stability by resisting iceberg calving. The motion of ice mélange is a result of inter-particle interactions between icebergs which are affected by ice mélange composition, fjord geometry, and driving forces. One of the significant features of this highly complex system is stick-slip flow that occurs as icebergs slide past each other. Here, we report on laboratory simulations of ice mélange motion. Plastic particles of various geometries are placed on the water surface in a meter-long channel and forced down the channel by a moving barrier. Our studies are focused on the impact of particle shapes, size distributions, and channel geometry on the flow behavior. The velocity fields of the experiments are analyzed and compared to numerical simulations and field observations. We relate the flow behavior to the back-stress provided by ice mélange, and find that it depends strongly on particle shape and channel geometry.

  9. SimGraph: A Flight Simulation Data Visualization Workstation

    NASA Technical Reports Server (NTRS)

    Kaplan, Joseph A.; Kenney, Patrick S.

    1997-01-01

    Today's modern flight simulation research produces vast amounts of time sensitive data, making a qualitative analysis of the data difficult while it remains in a numerical representation. Therefore, a method of merging related data together and presenting it to the user in a more comprehensible format is necessary. Simulation Graphics (SimGraph) is an object-oriented data visualization software package that presents simulation data in animated graphical displays for easy interpretation. Data produced from a flight simulation is presented by SimGraph in several different formats, including: 3-Dimensional Views, Cockpit Control Views, Heads-Up Displays, Strip Charts, and Status Indicators. SimGraph can accommodate the addition of new graphical displays to allow the software to be customized to each user s particular environment. A new display can be developed and added to SimGraph without having to design a new application, allowing the graphics programmer to focus on the development of the graphical display. The SimGraph framework can be reused for a wide variety of visualization tasks. Although it was created for the flight simulation facilities at NASA Langley Research Center, SimGraph can be reconfigured to almost any data visualization environment. This paper describes the capabilities and operations of SimGraph.

  10. SIMS analysis: Development and evaluation 1994 summary report

    SciTech Connect

    Groenewold, G.S.; Appelhans, A.D.; Ingram, J.C.; Delmore, J.E.; Dahl, D.A.

    1994-12-01

    Secondary ion mass spectrometry (SIMS) was evaluated for applicability to the characterization of salt cake and environmental samples. Salt cake is representative of waste found in radioactive waste storage tanks located at Hanford and at other DOE sites; it consists of nitrate, nitrite, hydroxide, and ferrocyanide salts, and the samples form the tanks are extremely radioactive. SIMS is an attractive technology for characterizing these samples because it has the capability for producing speciation information with little or no sample preparation, and it generates no additional waste. Experiments demonstrated that substantial speciation information could be readily generated using SIMS: metal clusters which include nitrate, nitrite, hydroxide, carbonate, cyanide, ferrocyanide and ferricyanide were observed. In addition, the mechanism of SIMS desorption of tributyl phosphate (TBP) was clearly identified, and minimum detection limit studies involving TBP were performed. Procurements leading to the construction of an ion trap SIMS instrument were initiated. Technology transfer of SIMS components to three instrument vendors was initiated. For FY-95, the SIMS evaluation program has been redirected toward identification of metal species on environmental samples.

  11. SIM PlanetQuest: Science with the Space Interferometry Mission

    NASA Technical Reports Server (NTRS)

    Unwin, Stephen (Editor); Turyshev, Slava (Editor)

    2004-01-01

    SIM - the Space Interferometry Mission - will perform precision optical astrometry on objects as faint as R magnitude 20. It will be the first space-based astrometric interferometer, operating in the optical band with a 10-m baseline. The Project is managed by the Jet Propulsion Laboratory, California Institute of Technology, in close collaboration with two industry partners, Lockheed Martin Missiles and Space, and TRW Inc., Space and Electronics Group. Launch of SIM is currently planned for 2009. In its wide-angle astrometric mode, SIM will yield 4 microarcsecond absolute position and parallax measurements. Astrometric planet searches will be done in a narrow-angle mode, with an accuracy of 4 microarcseconds or better in a single measurement. As a pointed rather than a survey instrument, SIM will maintain.its astrometric accuracy down to the faintest, magnitudes, opening up the opportunity for astrometry of active galactic nuclei to better than 10 pas. SIM will define a new astrometric reference frame, using a grid of approximately 1500 stars with positions accurate to 4 microarcseconds. The SIM Science Team comprises the Principal Investigators of ten Key Projects, and five Mission Scientists contributing their expertise to specific areas of the mission. Their science programs cover a wide range of topics in Galactic and extragalactic astronomy. They include: searches for low-mass planets - including analogs to our own solar system - tlie formation and dynamics of our Galaxy, calibration of the cosmic distance scale, and fundamental stellar astrophysics. All of the science observing on SIM is competitively awarded; the Science Team programs total about 40% of the total available, and the remainder will be assigned via future NASA competitions. This report is a compilation of science summaries by members of the Science Team, and it illustrates the wealth of scientific problems that microarcsecond-precision astrometry can contribute to. More information on SIM

  12. Deforming the Maxwell-Sim algebra

    SciTech Connect

    Gibbons, G. W.; Gomis, Joaquim; Pope, C. N.

    2010-09-15

    The Maxwell algebra is a noncentral extension of the Poincare algebra, in which the momentum generators no longer commute, but satisfy [P{sub {mu}},P{sub {nu}}]=Z{sub {mu}{nu}}. The charges Z{sub {mu}{nu}} commute with the momenta, and transform tensorially under the action of the angular momentum generators. If one constructs an action for a massive particle, invariant under these symmetries, one finds that it satisfies the equations of motion of a charged particle interacting with a constant electromagnetic field via the Lorentz force. In this paper, we explore the analogous constructions where one starts instead with the ISim subalgebra of Poincare, this being the symmetry algebra of very special relativity. It admits an analogous noncentral extension, and we find that a particle action invariant under this Maxwell-Sim algebra again describes a particle subject to the ordinary Lorentz force. One can also deform the ISim algebra to DISim{sub b}, where b is a nontrivial dimensionless parameter. We find that the motion described by an action invariant under the corresponding Maxwell-DISim algebra is that of a particle interacting via a Finslerian modification of the Lorentz force. In an appendix is it shown that the DISim{sub b} algebra is isomorphic to the extended Schroedinger algebra with its standard deformation parameter z, when b=(1/1-z).

  13. Waveguide Harmonic Generator for the SIM

    NASA Technical Reports Server (NTRS)

    Chang, Daniel; Poberezhskiy, Ilya; Mulder, Jerry

    2008-01-01

    A second-harmonic generator (SHG) serves as the source of the visible laser beam in an onboard calibration scheme for NASA's planned Space Interferometry Mission (SIM), which requires an infrared laser beam and a visible laser beam coherent with the infrared laser beam. The SHG includes quasi-phase-matched waveguides made of MgO-doped, periodically poled lithium niobate, pigtailed with polarization- maintaining optical fibers. Frequency doubling by use of such waveguides affords the required combination of coherence and sufficient conversion efficiency for the intended application. The spatial period of the poling is designed to obtain quasi-phase- matching at a nominal middle excitation wavelength of 1,319.28 nm. The SHG is designed to operate at a warm bias (ambient temperature between 20 and 25 C) that would be maintained in its cooler environment by use of electric heaters; the heater power would be adjusted to regulate the temperature precisely and thereby maintain the required precision of the spatial period. At the state of development at the time of this reporting, the SHG had been packaged and subjected to most of its planned space-qualification tests.

  14. Port-O-Sim Object Simulation Application

    NASA Technical Reports Server (NTRS)

    Lanzi, Raymond J.

    2009-01-01

    Port-O-Sim is a software application that supports engineering modeling and simulation of launch-range systems and subsystems, as well as the vehicles that operate on them. It is flexible, distributed, object-oriented, and realtime. A scripting language is used to configure an array of simulation objects and link them together. The script is contained in a text file, but executed and controlled using a graphical user interface. A set of modules is defined, each with input variables, output variables, and settings. These engineering models can be either linked to each other or run as standalone. The settings can be modified during execution. Since 2001, this application has been used for pre-mission failure mode training for many Range Safety Scenarios. It contains range asset link analysis, develops look-angle data, supports sky-screen site selection, drives GPS (Global Positioning System) and IMU (Inertial Measurement Unit) simulators, and can support conceptual design efforts for multiple flight programs with its capacity for rapid six-degrees-of-freedom model development. Due to the assembly of various object types into one application, the application is applicable across a wide variety of launch range problem domains.

  15. [Cornelia de Lange Syndrome and multiple hormonal deficiency, an unusual association. Clinical case].

    PubMed

    Mora-Bautista, Víctor M; Mendoza-Rojas, Víctor; Contreras-García, Gustavo A

    2017-06-01

    Cornelia de Lange syndrome is a genetic disease characterized by distinctive facial features, failure to thrive, microcephaly and several malformations associated. Its main endocrinological features are anomalies of the genitalia. We present a 13-year-old boy, who suffered from complicated aspiration pneumonia and showed Cornelia de Lange syndrome phenotype, with global developmental delay, suction-swallowing abnormalities, short stature and abnormal genitalia associated. His bone age was delayed, so he underwent full endocrinological panel. Central hypothyroidism, growth hormone deficiency and low luteinizing hormone-follicle-stimulating hormone levels were observed and multiple pituitary hormone deficiencies diagnosis was made. Basal cortisol, adrenocorticotropic hormone and prolactin levels were normal. He received thyroid hormonal substitution. Multiple pituitary hormone deficiencies are an unusual feature of De Lange syndrome. We suggest evaluating all different endocrine axes in these patients. Sociedad Argentina de Pediatría.

  16. Behavioral Phenotype and Autism Spectrum Disorders in Cornelia de Lange Syndrome.

    PubMed

    Parisi, Lucia; Di Filippo, Teresa; Roccella, Michele

    2015-09-30

    Cornelia de Lange syndrome (CdLS) is a congenital disorder characterized by distinctive facial features, growth retardation, limb abnormalities, intellectual disability, and behavioral problems. Cornelia de Lange syndrome is associated with abnormalities on chromosomes 5, 10 and X. Heterozygous point mutations in three genes (NIPBL, SMC3 and SMC1A), are responsible for approximately 50-60% of CdLS cases. CdLS is characterized by autistic features, notably excessive repetitive behaviors and expressive language deficits. The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in CdLS. However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. A significantly higher prevalence of self-injury are evident in CdLS. Self-injury was associated with repetitive and impulsive behavior. This study describes the behavioral phenotype of four children with Cornelia de Lange syndrome and ASDs and rehabilitative intervention that must be implemented.

  17. Sub-nanometer Level Model Validation of the SIM Interferometer

    NASA Technical Reports Server (NTRS)

    Korechoff, Robert P.; Hoppe, Daniel; Wang, Xu

    2004-01-01

    The Space Interferometer Mission (SIM) flight instrument will not undergo a full performance, end-to-end system test on the ground due to a number of constraints. Thus, analysis and physics-based models will play a significant role in providing confidence that SIM will meet its science goals on orbit. The various models themselves are validated against the experimental results obtained from the MicroArcsecond Metrology (MAM) testbed adn the Diffraction testbed (DTB). The metric for validation is provided by the SIM astrometric error budget.

  18. The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome.

    PubMed

    Schwartz, Charles E; Stevenson, Roger E

    2007-06-01

    Thyroid hormone is essential for the proper development and function of the brain. The active form of thyroid hormone is T(3), which binds to nuclear receptors. Recently, a transporter specific for T(3), MCT8 (monocarboxylate transporter 8) was identified. MCT8 is highly expressed in liver and brain. The gene is located in Xq13 and mutations in MCT8 are responsible for an X-linked condition, Allan-Herndon-Dudley syndrome (AHDS). This syndrome is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays. Affected males also present with muscle hypoplasia, generalized muscle weakness, and limited speech. Importantly, these patients have elevated serum levels of free T(3), low to below normal serum levels of free T(4), and levels of thyroid stimulating hormone that are within the normal range. This constellation of measurements of thyroid function enables quick screening for AHDS in males presenting with cognitive impairment, congenital hypotonia, and generalized muscle weakness.

  19. Investigations into an unknown organism on the martian meteorite Allan Hills 84001

    NASA Technical Reports Server (NTRS)

    Steele, A.; Goddard, D. T.; Stapleton, D.; Toporski, J. K.; Peters, V.; Bassinger, V.; Sharples, G.; Wynn-Williams, D. D.; McKay, D. S.

    2000-01-01

    Examination of fracture surfaces near the fusion crust of the martian meteorite Allan Hills (ALH) 84001 have been conducted using scanning electron microscopy (SEM) and atomic force microscopy (AFM) and has revealed structures strongly resembling mycelium. These structures were compared with similar structures found in Antarctic cryptoendolithic communities. On morphology alone, we conclude that these features are not only terrestrial in origin but probably belong to a member of the Actinomycetales, which we consider was introduced during the Antarctic residency of this meteorite. If true, this is the first documented account of terrestrial microbial activity within a meteorite from the Antarctic blue ice fields. These structures, however, do not bear any resemblance to those postulated to be martian biota, although they are a probable source of the organic contaminants previously reported in this meteorite.

  20. Investigations into an unknown organism on the martian meteorite Allan Hills 84001

    NASA Technical Reports Server (NTRS)

    Steele, A.; Goddard, D. T.; Stapleton, D.; Toporski, J. K.; Peters, V.; Bassinger, V.; Sharples, G.; Wynn-Williams, D. D.; McKay, D. S.

    2000-01-01

    Examination of fracture surfaces near the fusion crust of the martian meteorite Allan Hills (ALH) 84001 have been conducted using scanning electron microscopy (SEM) and atomic force microscopy (AFM) and has revealed structures strongly resembling mycelium. These structures were compared with similar structures found in Antarctic cryptoendolithic communities. On morphology alone, we conclude that these features are not only terrestrial in origin but probably belong to a member of the Actinomycetales, which we consider was introduced during the Antarctic residency of this meteorite. If true, this is the first documented account of terrestrial microbial activity within a meteorite from the Antarctic blue ice fields. These structures, however, do not bear any resemblance to those postulated to be martian biota, although they are a probable source of the organic contaminants previously reported in this meteorite.

  1. A unique type 3 ordinary chondrite containing graphite-magnetite aggregates - Allan Hills A77011

    NASA Technical Reports Server (NTRS)

    Mckinley, S. G.; Scott, E. R. D.; Taylor, G. J.; Keil, K.

    1982-01-01

    ALHA 77011, which is the object of study in the present investigation, is a chondrite of the 1977 meteorite collection from Allan Hills, Antarctica. It contains an opaque and recrystallized silicate matrix (Huss matrix) and numerous aggregates consisting of micron- and submicron-sized graphite and magnetite. It is pointed out that no abundant graphite-magnetite aggregates could be observed in other type 3 ordinary chondrites, except for Sharps. Attention is given to the results of a modal analysis, relations between ALHA 77011 and other type 3 ordinary chondrites, and the association of graphite-magnetite and metallic Fe, Ni. The discovery of graphite-magnetite aggregates in type 3 ordinary chondrites is found to suggest that this material may have been an important component in the formation of ordinary chondrites.

  2. Composition of bulk samples and a possible pristine clast from Allan Hills A81005

    NASA Technical Reports Server (NTRS)

    Boynton, W. V.; Hill, D. H.

    1983-01-01

    Abundances of thirty-five elements were determined in two bulk samples and a white clast in the Allan Hills A81005 meteorite. High siderophile element content indicates that the sample is a regolith breccia. An Fe/Mn ratio of 77 in this meteorite eliminates parent bodies of known differentiated meteorites as the source of ALHA 81005. The incompatible elements are very similar to those found in most lunar highlands rocks, and provide very strong evidence that the sample is lunar in origin. The clast sample has the trace element pattern of a lunar anorthosite and is very low in KREEP and siderophile elements. It may be a fragment of a pristine lunar rock.

  3. Element distribution and noble gas isotopic abundances in lunar meteorite Allan Hills A81005

    NASA Technical Reports Server (NTRS)

    Kraehenbuehl, U.; Eugster, O.; Niedermann, S.

    1986-01-01

    Antarctic meteorite ALLAN HILLS A81005, an anorthositic breccia, is recognized to be of lunar origin. The noble gases in this meteorite were analyzed and found to be solar-wind implanted gases, whose absolute and relative concentrations are quite similar to those in lunar regolith samples. A sample of this meteorite was obtained for the analysis of the noble gas isotopes, including Kr(81), and for the determination of the elemental abundances. In order to better determine the volume derived from the surface correlated gases, grain size fractions were prepared. The results of the instrumental measurements of the gamma radiation are listed. From the amounts of cosmic ray produced noble gases and respective production rates, the lunar surface residence times were calculated. It was concluded that the lunar surface time is about half a billion years.

  4. Investigations into an unknown organism on the martian meteorite Allan Hills 84001.

    PubMed

    Steele, A; Goddard, D T; Stapleton, D; Toporski, J K; Peters, V; Bassinger, V; Sharples, G; Wynn-Williams, D D; McKay, D S

    2000-03-01

    Examination of fracture surfaces near the fusion crust of the martian meteorite Allan Hills (ALH) 84001 have been conducted using scanning electron microscopy (SEM) and atomic force microscopy (AFM) and has revealed structures strongly resembling mycelium. These structures were compared with similar structures found in Antarctic cryptoendolithic communities. On morphology alone, we conclude that these features are not only terrestrial in origin but probably belong to a member of the Actinomycetales, which we consider was introduced during the Antarctic residency of this meteorite. If true, this is the first documented account of terrestrial microbial activity within a meteorite from the Antarctic blue ice fields. These structures, however, do not bear any resemblance to those postulated to be martian biota, although they are a probable source of the organic contaminants previously reported in this meteorite.

  5. The MCT8 thyroid hormone transporter and Allan--Herndon--Dudley syndrome

    PubMed Central

    Schwartz, Charles E.; Stevenson, Roger E.

    2007-01-01

    Thyroid hormone is essential for the proper development and function of the brain. The active form of thyroid hormone is T3, which binds to nuclear receptors. Recently, a transporter specific for T3, MCT8 (monocarboxylate transporter 8) was identified. MCT8 is highly expressed in liver and brain. The gene is located in Xq13 and mutations in MCT8 are responsible for an X-linked condition, Allan--Herndon--Dudley syndrome (AHDS). This syndrome is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays. Affected males also present with muscle hypoplasia, generalized muscle weakness, and limited speech. Importantly, these patients have elevated serum levels of free T3, low to below normal serum levels of free T4, and levels of thyroid stimulating hormone that are within the normal range. This constellation of measurements of thyroid function enables quick screening for AHDS in males presenting with mental retardation, congenital hypotonia, and generalized muscle weakness. PMID:17574010

  6. Analysis of chaotic and noise processes in a fluctuating blood flow using the Allan variance technique.

    PubMed

    Basarab, M A; Basarab, D A; Konnova, N S; Matsievskiy, D D; Matveev, V A

    2016-01-01

    The aim of this work was to develop a novel technique for digital processing of Doppler ultrasound blood flow sensor data from noisy blood flow velocity waveforms. To evaluate the fluctuating blood flow parameters, various nonlinear dynamics methods and algorithms are often being used. Here, for identification of chaotic and noise components in a fluctuating coronary blood flow, for the first time the Allan variance technique was used. Analysis of different types of noises (White, Brownian, Flicker) was carried out and their strong correlation with fractality of time series (the Hurst exponent) was revealed. Based on a specialized software realizing the developed technique, numerical experiments with real clinical data were carried out. Recommendations for identification of noisy patterns of coronary blood flow in normal and pathological states were developed. The methodology gives us the possibility for the more detailed quantitative and qualitative analysis of a noisy fluctuating blood flow data.

  7. A unique type 3 ordinary chondrite containing graphite-magnetite aggregates - Allan Hills A77011

    NASA Technical Reports Server (NTRS)

    Mckinley, S. G.; Scott, E. R. D.; Taylor, G. J.; Keil, K.

    1982-01-01

    ALHA 77011, which is the object of study in the present investigation, is a chondrite of the 1977 meteorite collection from Allan Hills, Antarctica. It contains an opaque and recrystallized silicate matrix (Huss matrix) and numerous aggregates consisting of micron- and submicron-sized graphite and magnetite. It is pointed out that no abundant graphite-magnetite aggregates could be observed in other type 3 ordinary chondrites, except for Sharps. Attention is given to the results of a modal analysis, relations between ALHA 77011 and other type 3 ordinary chondrites, and the association of graphite-magnetite and metallic Fe, Ni. The discovery of graphite-magnetite aggregates in type 3 ordinary chondrites is found to suggest that this material may have been an important component in the formation of ordinary chondrites.

  8. Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene.

    PubMed

    Schwartz, Charles E; May, Melanie M; Carpenter, Nancy J; Rogers, R Curtis; Martin, Judith; Bialer, Martin G; Ward, Jewell; Sanabria, Javier; Marsa, Silvana; Lewis, James A; Echeverri, Roberto; Lubs, Herbert A; Voeller, Kytja; Simensen, Richard J; Stevenson, Roger E

    2005-07-01

    Allan-Herndon-Dudley syndrome was among the first of the X-linked mental retardation syndromes to be described (in 1944) and among the first to be regionally mapped on the X chromosome (in 1990). Six large families with the syndrome have been identified, and linkage studies have placed the gene locus in Xq13.2. Mutations in the monocarboxylate transporter 8 gene (MCT8) have been found in each of the six families. One essential function of the protein encoded by this gene appears to be the transport of triiodothyronine into neurons. Abnormal transporter function is reflected in elevated free triiodothyronine and lowered free thyroxine levels in the blood. Infancy and childhood in the Allan-Herndon-Dudley syndrome are marked by hypotonia, weakness, reduced muscle mass, and delay of developmental milestones. Facial manifestations are not distinctive, but the face tends to be elongated with bifrontal narrowing, and the ears are often simply formed or cupped. Some patients have myopathic facies. Generalized weakness is manifested by excessive drooling, forward positioning of the head and neck, failure to ambulate independently, or ataxia in those who do ambulate. Speech is dysarthric or absent altogether. Hypotonia gives way in adult life to spasticity. The hands exhibit dystonic and athetoid posturing and fisting. Cognitive development is severely impaired. No major malformations occur, intrauterine growth is not impaired, and head circumference and genital development are usually normal. Behavior tends to be passive, with little evidence of aggressive or disruptive behavior. Although clinical signs of thyroid dysfunction are usually absent in affected males, the disturbances in blood levels of thyroid hormones suggest the possibility of systematic detection through screening of high-risk populations.

  9. The Natural Thermoluminescence of Meteorites. Part 5; Ordinary Chondrites at the Allan Hills Ice Fields

    NASA Technical Reports Server (NTRS)

    Benoit, Paul H.; Sears, Hazel; Sears, Derek W. G.

    1993-01-01

    Natural thermoluminescence (TL) data have been obtained for 167 ordinary chondrites from the ice fields in the vicinity of the Allan Hills in Victoria Land, Antarctica, in order to investigate their thermal and radiation history, pairing, terrestrial age, and concentration mechanisms. Using fairly conservative criteria (including natural and induced TL, find location, and petrographic data), the 167 meteorite fragments are thought to represent a maximum of 129 separate meteorites. Natural TL values for meteorites from the Main ice field are fairly low (typically 5-30 krad, indicative of terrestrial ages of approx. 400 ka), while the Far western field shows a spread with many values 30-80 krad, suggestive of less then 150-ka terrestrial ages. There appear to be trends in TL levels within individual ice fields which are suggestive of directions of ice movement at these sites during the period of meteorite concentration. These directions seem to be confirmed by the orientations of elongation preserved in meteorite pairing groups. The proportion of meteorites with very low natural TL levels (less then 5 krad) at each field is comparable to that observed at the Lewis Cliff site and for modern non-Antarctic falls and is also similar to the fraction of small perihelia (less then 0.85 AU) orbits calculated from fireball and fall observations. Induced TL data for meteorites from the Allan Hills confirm trends observed for meteorites collected during the 1977/1978 and 1978/1979 field seasons which show that a select group of H chondrites from the Antarctic experienced a different extraterrestrial thermal history to that of non-Antarctic H chondrites.

  10. Application of Fast Dynamic Allan Variance for the Characterization of FOGs-Based Measurement While Drilling

    PubMed Central

    Wang, Lu; Zhang, Chunxi; Gao, Shuang; Wang, Tao; Lin, Tie; Li, Xianmu

    2016-01-01

    The stability of a fiber optic gyroscope (FOG) in measurement while drilling (MWD) could vary with time because of changing temperature, high vibration, and sudden power failure. The dynamic Allan variance (DAVAR) is a sliding version of the Allan variance. It is a practical tool that could represent the non-stationary behavior of the gyroscope signal. Since the normal DAVAR takes too long to deal with long time series, a fast DAVAR algorithm has been developed to accelerate the computation speed. However, both the normal DAVAR algorithm and the fast algorithm become invalid for discontinuous time series. What is worse, the FOG-based MWD underground often keeps working for several days; the gyro data collected aboveground is not only very time-consuming, but also sometimes discontinuous in the timeline. In this article, on the basis of the fast algorithm for DAVAR, we make a further advance in the fast algorithm (improved fast DAVAR) to extend the fast DAVAR to discontinuous time series. The improved fast DAVAR and the normal DAVAR are used to responsively characterize two sets of simulation data. The simulation results show that when the length of the time series is short, the improved fast DAVAR saves 78.93% of calculation time. When the length of the time series is long (6×105 samples), the improved fast DAVAR reduces calculation time by 97.09%. Another set of simulation data with missing data is characterized by the improved fast DAVAR. Its simulation results prove that the improved fast DAVAR could successfully deal with discontinuous data. In the end, a vibration experiment with FOGs-based MWD has been implemented to validate the good performance of the improved fast DAVAR. The results of the experience testify that the improved fast DAVAR not only shortens computation time, but could also analyze discontinuous time series. PMID:27941600

  11. Application of Fast Dynamic Allan Variance for the Characterization of FOGs-Based Measurement While Drilling.

    PubMed

    Wang, Lu; Zhang, Chunxi; Gao, Shuang; Wang, Tao; Lin, Tie; Li, Xianmu

    2016-12-07

    The stability of a fiber optic gyroscope (FOG) in measurement while drilling (MWD) could vary with time because of changing temperature, high vibration, and sudden power failure. The dynamic Allan variance (DAVAR) is a sliding version of the Allan variance. It is a practical tool that could represent the non-stationary behavior of the gyroscope signal. Since the normal DAVAR takes too long to deal with long time series, a fast DAVAR algorithm has been developed to accelerate the computation speed. However, both the normal DAVAR algorithm and the fast algorithm become invalid for discontinuous time series. What is worse, the FOG-based MWD underground often keeps working for several days; the gyro data collected aboveground is not only very time-consuming, but also sometimes discontinuous in the timeline. In this article, on the basis of the fast algorithm for DAVAR, we make a further advance in the fast algorithm (improved fast DAVAR) to extend the fast DAVAR to discontinuous time series. The improved fast DAVAR and the normal DAVAR are used to responsively characterize two sets of simulation data. The simulation results show that when the length of the time series is short, the improved fast DAVAR saves 78.93% of calculation time. When the length of the time series is long ( 6 × 10 5 samples), the improved fast DAVAR reduces calculation time by 97.09%. Another set of simulation data with missing data is characterized by the improved fast DAVAR. Its simulation results prove that the improved fast DAVAR could successfully deal with discontinuous data. In the end, a vibration experiment with FOGs-based MWD has been implemented to validate the good performance of the improved fast DAVAR. The results of the experience testify that the improved fast DAVAR not only shortens computation time, but could also analyze discontinuous time series.

  12. The Natural Thermoluminescence of Meteorites. Part 5; Ordinary Chondrites at the Allan Hills Ice Fields

    NASA Technical Reports Server (NTRS)

    Benoit, Paul H.; Sears, Hazel; Sears, Derek W. G.

    1993-01-01

    Natural thermoluminescence (TL) data have been obtained for 167 ordinary chondrites from the ice fields in the vicinity of the Allan Hills in Victoria Land, Antarctica, in order to investigate their thermal and radiation history, pairing, terrestrial age, and concentration mechanisms. Using fairly conservative criteria (including natural and induced TL, find location, and petrographic data), the 167 meteorite fragments are thought to represent a maximum of 129 separate meteorites. Natural TL values for meteorites from the Main ice field are fairly low (typically 5-30 krad, indicative of terrestrial ages of approx. 400 ka), while the Far western field shows a spread with many values 30-80 krad, suggestive of less then 150-ka terrestrial ages. There appear to be trends in TL levels within individual ice fields which are suggestive of directions of ice movement at these sites during the period of meteorite concentration. These directions seem to be confirmed by the orientations of elongation preserved in meteorite pairing groups. The proportion of meteorites with very low natural TL levels (less then 5 krad) at each field is comparable to that observed at the Lewis Cliff site and for modern non-Antarctic falls and is also similar to the fraction of small perihelia (less then 0.85 AU) orbits calculated from fireball and fall observations. Induced TL data for meteorites from the Allan Hills confirm trends observed for meteorites collected during the 1977/1978 and 1978/1979 field seasons which show that a select group of H chondrites from the Antarctic experienced a different extraterrestrial thermal history to that of non-Antarctic H chondrites.

  13. Allan-Herndon-Dudley Syndrome and the Monocarboxylate Transporter 8 (MCT8) Gene

    PubMed Central

    Schwartz, Charles E. ; May, Melanie M. ; Carpenter, Nancy J. ; Rogers, R. Curtis ; Martin, Judith ; Bialer, Martin G. ; Ward, Jewell ; Sanabria, Javier ; Marsa, Silvana ; Lewis, James A. ; Echeverri, Roberto ; Lubs, Herbert A. ; Voeller, Kytja ; Simensen, Richard J. ; Stevenson, Roger E. 

    2005-01-01

    Allan-Herndon-Dudley syndrome was among the first of the X-linked mental retardation syndromes to be described (in 1944) and among the first to be regionally mapped on the X chromosome (in 1990). Six large families with the syndrome have been identified, and linkage studies have placed the gene locus in Xq13.2. Mutations in the monocarboxylate transporter 8 gene (MCT8) have been found in each of the six families. One essential function of the protein encoded by this gene appears to be the transport of triiodothyronine into neurons. Abnormal transporter function is reflected in elevated free triiodothyronine and lowered free thyroxine levels in the blood. Infancy and childhood in the Allan-Herndon-Dudley syndrome are marked by hypotonia, weakness, reduced muscle mass, and delay of developmental milestones. Facial manifestations are not distinctive, but the face tends to be elongated with bifrontal narrowing, and the ears are often simply formed or cupped. Some patients have myopathic facies. Generalized weakness is manifested by excessive drooling, forward positioning of the head and neck, failure to ambulate independently, or ataxia in those who do ambulate. Speech is dysarthric or absent altogether. Hypotonia gives way in adult life to spasticity. The hands exhibit dystonic and athetoid posturing and fisting. Cognitive development is severely impaired. No major malformations occur, intrauterine growth is not impaired, and head circumference and genital development are usually normal. Behavior tends to be passive, with little evidence of aggressive or disruptive behavior. Although clinical signs of thyroid dysfunction are usually absent in affected males, the disturbances in blood levels of thyroid hormones suggest the possibility of systematic detection through screening of high-risk populations. PMID:15889350

  14. Allan Hills 76005 Polymict Eucrite Pairing Group: Curatorial and Scientific Update on a Jointly Curated Meteorite

    NASA Technical Reports Server (NTRS)

    Righter, K.

    2011-01-01

    Allan Hills 76005 (or 765) was collected by the joint US-Japan field search for meteorites in 1976-77. It was described in detail as "pale gray in color and consists of finely divided macrocrystalline pyroxene-rich matrix that contains abundant clastic fragments: (1) Clasts of white, plagioclase-rich rocks. (2) Medium-gray, partly devitrified, cryptocrystalline. (3) Monomineralic fragments and grains of pyroxene, plagioclases, oxide minerals, sulfides, and metal. In overall appearance it is very similar to some lunar breccias." Subsequent studies found a great diversity of basaltic clast textures and compositions, and therefore it is best classified as a polymict eucrite. Samples from the 1976-77, 77-78, and 78-79 field seasons (76, 77, and 78 prefixes) were split between US and Japan (NIPR). The US specimens are currently at NASA-JSC, Smithsonian Institution, or the Field Museum in Chicago. After this initial finding of ALH 76005, the next year s team recovered one additional mass ALH 77302, and then four additional masses were found during the third season ALH 78040 and ALH 78132, 78158 and 78165. The joint US-Japan collection effort ended after three years and the US began collecting in the Trans-Antarctic Mountains with the 1979-80 and subsequent field seasons. ALH 79017 and ALH 80102 were recovered in these first two years, and then in 1981-82 field season, 6 additional masses were recovered from the Allan Hills. Of course it took some time to establish pairing of all of these specimens, but altogether the samples comprise 4292.4 g of material. Here will be summarized the scientific findings as well as some curatorial details of how specimens have been subdivided and allocated for study. A detailed summary is also presented on the NASA-JSC curation webpage for the HED meteorite compendium.

  15. Development of tectono-sedimentary mélanges in accretionary wedges: Insights from analog modeling

    NASA Astrophysics Data System (ADS)

    Genti, M.; Malavieille, J.; Molli, G.; Dominguez, S.; Taboada, A.; Vitale-Brovarone, A.

    2012-04-01

    Orogenic wedges locally present chaotic tectonostratigraphic units that contain exotic blocks of various size, origin, age and lithology, embedded in a sedimentary matrix. The occurrence of ophiolitic blocks, sometimes huge, in such "mélanges" raises questions on i) the mechanisms responsible for the incorporation of oceanic basement rocks into an accretionary wedge and ii) the mechanisms allowing exhumation and possibly redeposition of these exotic elements in "mélanges" during wedge growth. The tectonic evolution of the back part of doubly vergent accretionary wedges is mainly controled by backthrusting. The retrowedge is characterized by steep slopes that are prone to gravitational instabilities. We assume that these steep slopes trigger submarine landslides playing a major erosional role and therefore inducing huge mass transfers. This erosion allows exhumation of the ophiolitic fragments formerly accreted at the base of the wedge and then reworked as tectono-sedimentary "mélanges" redeposited in proximal basins located at the base of the retrowedge slope. These basin deposits are then continuously involved in backthrusting-induced deformation. In this study, we present the results of a series of analog experiments performed to characterize the processes and parameters responsible for accretion, exhumation and final tectonosedimentary reworking of oceanic basement lithosphere fragments in an accretionary wedge. The experimental setup is designed to simulate the interaction between tectonics, erosion and sedimentation. Different configurations are applied to study the impact of various parameters, such as irregular oceanic floor due to structural inheritance, or the presence of layers with contrasted rheology that can affect deformation partitioning in the wedge (frontal accretion vs basal accretion) influencing its growth. The experimental results are then compared with observations on ophiolite-bearing mélanges in the Taïwan (Lichi mélange) and northern

  16. Interdisciplinary therapy in Cornelia de Lange syndrome - review of the literature.

    PubMed

    Mikołajewska, Emilia

    2013-01-01

    Cornelia de Lange syndrome (CdLS, also called Brachmann-de Lange syndrome - BdLS) is a multisystem developmental disorder characterized by distinctive facial features, growth and mental retardation, microcephaly, and various malformations. According to their clinical status, patients with CdLS require individual interdisciplinary therapy. The therapy is difficult and mainly symptomatic. To optimize the therapy results, early diagnosis programs and appropriate developmental and therapeutic intervention are recommended. The interdisciplinary approach described in the article needs further clinical research and detailed guidelines.

  17. Unpredictable drug reaction in a child with Cornelia de Lange syndrome.

    PubMed

    Stevic, Marija; Milojevic, Irina; Bokun, Zlatko; Simic, Dusica

    2015-02-01

    Preoperative use of midazolam sedation is mandatory during induction of anesthesia in noncooperative and hyperactive children to prevent possible obstacles. Unusual drug reactions rarely occur in patients undergoing anesthesia or in intensive care unit. This report describes an unpredictable drug reaction after a routine midazolam premedication in a patient with no history of allergy. There has been no literature data yet to show that midazolam can provoke respiratory problems in patients with Cornelia de Lange Syndrome. In our opinion midazolam should be avoided in patients with Cornelia de Lange Syndrome, which we enforced after first unpredictable reaction.

  18. Psychological Well-Being in Parents of Children with Angelman, Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Griffith, G. M.; Hastings, R. P.; Oliver, C.; Howlin, P.; Moss, J.; Petty, J.; Tunnicliffe, P.

    2011-01-01

    Background: The current study focuses on mothers and fathers of children with three rare genetic syndromes that are relatively unexplored in terms of family experience: Angelman syndrome, Cornelia de Lange syndrome and Cri du Chat syndrome. Method: Parents of children with Angelman syndrome (n = 15), Cornelia de Lange syndrome (n = 16) and Cri du…

  19. Psychological Well-Being in Parents of Children with Angelman, Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Griffith, G. M.; Hastings, R. P.; Oliver, C.; Howlin, P.; Moss, J.; Petty, J.; Tunnicliffe, P.

    2011-01-01

    Background: The current study focuses on mothers and fathers of children with three rare genetic syndromes that are relatively unexplored in terms of family experience: Angelman syndrome, Cornelia de Lange syndrome and Cri du Chat syndrome. Method: Parents of children with Angelman syndrome (n = 15), Cornelia de Lange syndrome (n = 16) and Cri du…

  20. Astrometric Planet Searches with SIM PlanetQuest

    NASA Technical Reports Server (NTRS)

    Beichman, Charles A.; Unwin, Stephen C.; Shao, Michael; Tanner, Angelle M.; Catanzarite, Joseph H.; March, Geoffrey W.

    2007-01-01

    SIM will search for planets with masses as small as the Earth's orbiting in the habitable zones' around more than 100 of the stars and could discover many dozen if Earth-like planets are common. With a planned 'Deep Survey' of 100-450 stars (depending on desired mass sensitivity) SIM will search for terrestrial planets around all of the candidate target stars for future direct detection missions such as Terrestrial Planet Finder and Darwin, SIM's 'Broad Survey' of 2010 stars will characterize single and multiple-planet systems around a wide variety of stellar types, including many now inaccessible with the radial velocity technique. In particular, SIM will search for planets around young stars providing insights into how planetary systems are born and evolve with time.

  1. SIM-Lite Instrument Description, Operation and Performance

    NASA Technical Reports Server (NTRS)

    Goullioud, Renaud

    2009-01-01

    SIM Lite Astrometric Observatory, a space borne mission to be located in a solar Earth-trailing orbit, will conduct high precision differential astrometry. During the 5-year mission, SIM Lite will search about 60 nearby Sun-like stars for exoplanets of mass down to one Earth mass, in the Habitable Zone of those stars. In addition, SIM Lite will survey the architecture of planetary systems of about 1000 stars of all ages and types. SIM Lite will also build a 4 micro-arc-second astrometric grid and perform global astrometry on a variety of astrophysics objects. The instrument consists of two Michelson stellar interferometers and a precision telescope. The Science interferometer is composed of two 50 cm collectors separated by a 6 meter baseline. The technology development was completed in 2005. The mission is now ready for full flight implementation.

  2. ToF-SIMS and XPS study of ancient papers

    NASA Astrophysics Data System (ADS)

    Benetti, Francesca; Marchettini, Nadia; Atrei, Andrea

    2011-01-01

    The surface composition of 18th century papers was investigated by means of ToF-SIMS and XPS. The aim of the present study was to explore the possibility of using these surface sensitive methods to obtain information which can help to determine the manufacturing process, provenance and state of conservation of ancient papers. The ToF-SIMS results indicate that the analyzed papers were sized by gelatin and that alum was added as hardening agent. The paper sheets produced in near geographical areas but in different paper mills exhibit a similar surface composition and morphology of the fibers as shown by the ToF-SIMS measurements. The ToF-SIMS and the XPS results indicate that a significant fraction of the cellulose fibers is not covered by the gelatin layer. This was observed for the ancient papers and for a modern handmade paper manufactured according to the old recipes.

  3. Sim Track User's Manual (v 1.0)

    SciTech Connect

    Luo, Y.

    2010-01-27

    SimTrack is a simple c++ library designed for the numeric particle tracking in the high energy accelerators. It adopts the 4th order symplectic integrator for the optical transport in the magnetic elements. The 4-D and 6-D weak-strong beam-beam treatments are integrated in it for the beam-beam studies. SimTrack is written with c++ class and standard template library. It provides versatile functions to manage elements and lines. It supports a large range of types of elements. New type of element can be easily created in the library. SimTrack calculates Twiss, coupling and fits tunes, chromaticities and corrects closed orbits. AC dipole and AC multipole are available in this library. SimTrack allows change of element parameters during tracking.

  4. Mechanical impact of sea-ice/mélange on marine terminating glaciers

    NASA Astrophysics Data System (ADS)

    Lindsey, D. S.; Dupont, T. K.

    2011-12-01

    Observations indicate that large portions of ice-sheet margins are currently undergoing rapid dynamic change. The role of the ocean and sea-ice in altering glacier dynamics is currently an active field of research. Sea-ice, along with encased icebergs and marine ice (known as mélange), has been hypothesized to potentially affect glacier calving rates. In winter, sea-ice forms, stiffening the mélange, forming something akin to a thin ice-shelf. In an embayment, the sea-ice/mélange connects embayment walls to the glacial terminus potentially weakening longitudinal strain-rates. As calving rates are strongly dependent on longitudinal strain-rates, a decrease in strain-rate decreases calving. In certain cases decreased calving can lead to a terminus advance resulting in increased lateral drag and decreased glacier velocity. The outlined process is one of several competing theories that help explain the winter terminus advance and associated decrease in velocity at Jakobshavn Isbræ in Greenland. This work assesses the potential mechanical impact sea-ice/mélange (referred hereafter as winter mélange) can have on glacier dynamics. We examine the conditions under which winter mélange can have a significant impact on longitudinal strain-rates. We utilize two calving parameterizations, one depending on ice strain-rate, and the other based on a crevasse depth criterion. Results are presented from a 1-D force balance analysis and 2D plan-view diagnostic model. The 2D model explicitly incorporates the winter mélange as a thin shelf of uniform thickness within the interior of the domain. The model can account for variations in density, thickness, and ice hardness between glacier and winter mélange. Several questions ultimately drive this research. Under what geometric and rheological conditions can winter mélange affect longitudinal strain-rates? How sensitive is the calving rate to a decrease in glacier strain-rate? More specifically, can a small change in

  5. SIMS prototype system 1 test results: Engineering analysis

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The space and domestic water solar heating system designated SIMS Prototype Systems 1 was evaluated. The test system used 720 ft (gross) of Solar Energy Products Air Collectors, a Solar Control Corporation SAM 20 Air Handler with Model 75-175 control unit, a Jackson Solar Storage tank with Rho Sigma Mod 106 controller, and 20 tons of rack storage. The test data analysis performed evaluates the system performance and documents the suitability of SIMS Prototype System 1 hardware for field installation.

  6. New Atomic Ion SIMS Facility at the Naval Research Laboratory

    NASA Astrophysics Data System (ADS)

    Grabowski, K. S.; Fazel, K. C.; Fahey, A. J.

    2014-12-01

    Mass spectrometry of particulates and few micrometer regions of samples by Secondary Ion Mass Spectrometry (SIMS) is a very useful analytical tool. However, there are limitations caused by interferences from molecular species, such as hydrides, oxides, and carbides. Above mass 90 u, these interferences (> 104 M/ΔM) can exceed the resolving power of SIMS. Accelerator Mass Spectrometry (AMS) is capable of eliminating such molecular ion interferences, but lacks spatial information and generally requires use of negative ions. This requirement limits its sensitivity, since actinide and lanthanide elements preferentially generate positive atomic ions (~104 : 1). The Naval Research Laboratory (NRL) has installed a hybrid SIMS-AMS system, using a Single Stage AMS as a replacement for the normal Cameca IMS 4f SIMS electron multiplier detector. The NRL design enables analysis of either positive or negative ions. Thus, this system offers the potential to provide SIMS-like particle and micro-scale analysis without a forest of signals from molecular species, and is capable of measuring important positive atomic ions. This should improve measurement sensitivity and precision to determine isotopic distributions of actinides, lanthanides, and transition metals; and elemental abundances of trace species in particles or small features. Initial measurements show that molecule intensities can be reduced by seven orders of magnitude while atomic ion intensities are only diminished ~50%. We have chosen to call this instrument an atomic ion SIMS, or ai-SIMS, for short. The effect of basic operational parameters such as ion energy, charge state, molecule destruction gas and its pressure will be described, and examples of the benefits and capabilities of ai-SIMS will be presented.

  7. The Enlisted Steady State-Simulation (ESS-SIM) Tool

    DTIC Science & Technology

    2014-07-01

    The Enlisted Steady State-Simulation ( ESS -SIM) Tool David M. Rodney • Peggy A. Golfin • Molly F. McIntosh DIM-2014-U-007587-Final July 2014 This...situation. We built and made use of a simulation model, ESS -Sim (Enlisted Steady- State Simulation), to obtain insights into attainable levels of...fleet manning and estimate the impact of policy changes on fleet man- ning. This information memorandum describes this model. Model overview We built ESS

  8. S-SIMS and MetA-SIMS study of organic additives in thin polymer coatings

    NASA Astrophysics Data System (ADS)

    Adriaensen, L.; Vangaever, F.; Lenaerts, J.; Gijbels, R.

    2006-07-01

    In the present study a methodology for TOF-S-SIMS measurements is developed to gain information on the distribution of molecules on and in polymer coatings (thickness ˜100 μm). Experiments were carried out on model systems consisting of one or more additive-containing polyvinylbutyral coatings. Several organic additives were selected: carbocyanine dyes, basonyl blue and the pharmaceutical risperidone. The additives have been measured as pure compounds on a Si substrate to obtain good reference spectra. After optimisation of the sample preparation method, the coatings were embedded in epoxy resin and stored in an oven (60 °C) for 24 h. Cross-sections were made by means of a microtome. S-SIMS spectra were taken on the prepared cross-sections before and after Au was deposited on the sample surface. Compared to the untreated samples, the Au covered samples give rise to more intense secondary ion signals. Generally, signals of the intact cations were more intense than those of the fragment ions. Apart from mass spectra, images of the additive distribution in the coatings could also be acquired by recording structural ion signals. It was possible to make secondary ion images of the additive molecule ions with a (sub)-micrometer lateral resolution.

  9. SIM key comparison for luminous flux. SIM.PR-K4

    NASA Astrophysics Data System (ADS)

    Matamoros, Carlos H.; Ohno, Yoshi; Zwinkels, Joanne; Cogno, Jorge A.; Couceiro, Iakyra B.

    2016-01-01

    In compliance with the established BIPM and CCPR policies and guidelines on comparisons, the SIM Photometry and Radiometry Working Group decided to conduct a key comparison on total luminous flux in order to provide an opportunity for its member National Metrology Institutes (NMIs) that did not participate in the CCPR-K4 comparison, to get a link to the reference value obtained for this quantity (the lumen) and to derive the corresponding degrees of equivalence. This SIM.PR-K4 was piloted by Centro Nacional de Metrología (CENAM), the NMI of Mexico and included the participation of five laboratories: CENAM (Mexico), INTI (Argentina), INMETRO (Brazil), NIST (USA, linking lab), and NRC (Canada, linking lab). The comparison, conducted in star type scheme, was run using three to four lamps per participant, and results are given in this report, including the unilateral degrees of equivalence. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  10. Combined SIMS, NanoSIMS, FTIR, and SEM Studies of OH in Nominally Anhydrous Minerals (NAMs)

    NASA Astrophysics Data System (ADS)

    Mosenfelder, J. L.; Le Voyer, M.; Rossman, G. R.; Guan, Y.; Bell, D. R.; Asimow, P. D.; Eiler, J.

    2010-12-01

    The accurate analysis of trace concentrations of hydrogen in NAMs is a long-standing problem, with wide-ranging implications in geology and planetology. SIMS and FTIR are two powerful and complementary analytical tools capable of measuring concentrations down to levels of less than 1 ppm H2O. Both methods, however, are subject to matrix effects and rely on other techniques such as manometry or nuclear reaction analysis (NRA) for quantitative calibration. We compared FTIR and SIMS data for a wide variety of NAMs: olivine, orthopyroxene, clinopyroxene, pyrope and grossular garnet, rutile, zircon, kyanite, andalusite, and sillimanite. Some samples were also characterized using high-resolution FE-SEM to assess the potential contribution of submicrocopic inclusions to the analyses. For SIMS, we use high mass resolution (≥5000 MRP) to measure 16O1H, using 30Si and/or 18O as reference isotopes. We use both primary standards, measured independently using manometry or NRA (e.g., [1]), and secondary standards, measured using polarized FTIR referenced back to calibrations developed on primary standards. Our major focus was on on olivine, for which we collected repeated calibration data with both SIMS and NanoSIMS, bracketing measurements of H diffusion profiles in both natural and experimentally annealed crystals at levels of 5-100 ppm H2O. With both instruments we establish low blanks (≤5 ppm) and high precision (typically less than 5% 2-σ errors in 16O1H/30Si), critical requirements for the low concentration levels being measured. Assessment of over 300 analyses on 11 olivines allows us to evaluate the suitability of different standards, several of which are in use in other laboratories [2,3,4]. Seven olivines, with 0-125 ppm H2O, give highly reproducible results and allow us to establish well-constrained calibration slopes with high correlation coefficients (r2 = 0.98-99), in contrast to previous studies [2,3,4]. However, four kimberlitic megacrysts with 140-243 ppm H

  11. KEY COMPARISONS: Final report: SIM regional comparison of ac-dc voltage transfer difference (SIM.EM.K6a, SIM.EM-K9 and SIM.EM-K11)

    NASA Astrophysics Data System (ADS)

    Campos, Sara; Filipski, Piotr; Izquierdo, Daniel; Afonso, Edson; Landim, Régis P.; Di Lillo, Lucas; Lipe, Thomas

    2009-01-01

    Three comparisons of ac-dc voltage transfer difference held from January to December 2004 are reported. Six NMIs in the SIM region took part: NRC (Canada), NIST (United States of America), CENAM (Mexico), INTI (Argentina), UTE (Uruguay) and INMETRO (Brazil). The comparisons were proposed to assess the measurement capabilities in ac-dc voltage transfer difference of the NMIs in the SIM region. The test points were selected to link the results with the equivalent CCEM Key Comparisons, through three NMIs participating in both SIM and CCEM key comparisons. Additionally, a SIM.EM-Supplementary comparison was proposed, in support of the SIM NMIs' power/energy meter calibration capabilities. One technical protocol and one travelling standard were used, to economize on time and resources. The report shows the degree of equivalence in the SIM region and also the degree of equivalence with the corresponding CCEM reference value. The results of all participants support the values and uncertainties of the applicable CMC entries for ac-dc voltage transfer difference in the Key Comparison Database held at the BIPM. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  12. From Tappan to Lange: Evolution of the Public Junior College Idea.

    ERIC Educational Resources Information Center

    Gallagher, Edward Arthur

    This study is a historical analysis of the public junior college idea and its emergence. The thoughts and actions of Henry P. Tappan, William W. Folwell, William R. Harper, David S. Jordan, and Alexis Lange contributed most to its origin and development. These men, products of the late nineteenth and early twentieth centuries, were strongly…

  13. Friedrich Albert Lange on neo-Kantianism, socialist Darwinism, and a psychology without a soul.

    PubMed

    Teo, Thomas

    2002-01-01

    Friedrich Albert Lange was a German philosopher, political theorist, educator, and psychologist who outlined an objective psychology in the 1860s. This article shows how some of the most important worldviews of the nineteenth century (Kantianism, Marxism, and Darwinism) were combined creatively in his thought system. He was crucial in the development of neo-Kantianism and incorporated psycho-physiological research on sensation and perception in order to defend Kant's epistemological idealism. Based on a critique of phrenology and philosophical psychology of his time, Lange developed a program of a psychology without a soul. He suggested that only those phenomena that can be observed and controlled should be studied, that psychology should focus on actions and speech, and that for each psychological event the corresponding physical or physiological processes should be identified. Lange opposed introspection and subjective accounts and promoted experiments and statistics. He also promoted Darwinism for psychology while developing a socialist progressive-democratic reading of Darwin in his social theory. The implications of socialist Darwinism on Lange's conceptualization of race are discussed and his prominence in nineteenth century philosophy and psychology is summarized. Copyright 2002 Wiley Periodicals, Inc.

  14. Foreign Language Authoring Systems: Judith Frommer's MacLang Spoken Here.

    ERIC Educational Resources Information Center

    Frommer, Judith

    1987-01-01

    MacLang, a user-friendly authoring system for the Macintosh computer, helps second language teachers prepare and tailor computer exercises and activities; is usable with any Roman-alphabet language, Russian, and Greek; gives students intelligent feedback; and allows students to control computer activity in order to individualize learning.…

  15. The Behavioural Phenotype of Cornelia de Lange Syndrome: A Study of 56 Individuals

    ERIC Educational Resources Information Center

    Basile, Emanuele; Villa, L.; Selicorni, A.; Molteni, M.

    2007-01-01

    Background: Few studies have investigated functional and behavioural variables of Cornelia de Lange Syndrome (CdLS) in a large sample of individuals. The aim of this study is to provide greater insight into the clinical, behavioural and cognitive characteristics that are associated with CdLS. Methods: In total, 56 individuals with CdLS…

  16. Congenital Deafness with Cardiac Arrhythmias: The Jervell and Lange-Nielsen Syndrome.

    ERIC Educational Resources Information Center

    Wahl, Richard A.; Macdonald, Dick, II

    1980-01-01

    The Jervell and Lange-Nielsen syndrome, affecting 0.3 percent of congenitally deaf persons, consists of severe cardiac arrhythmias and sensorineural hearing loss. The authors recommend that every congenitally deaf child with suspicious symptoms receive an electrocardiogram and that professionals who work with deaf children not only inform…

  17. Congenital Deafness with Cardiac Arrhythmias: The Jervell and Lange-Nielsen Syndrome.

    ERIC Educational Resources Information Center

    Wahl, Richard A.; Macdonald, Dick, II

    1980-01-01

    The Jervell and Lange-Nielsen syndrome, affecting 0.3 percent of congenitally deaf persons, consists of severe cardiac arrhythmias and sensorineural hearing loss. The authors recommend that every congenitally deaf child with suspicious symptoms receive an electrocardiogram and that professionals who work with deaf children not only inform…

  18. Foreign Language Authoring Systems: Judith Frommer's MacLang Spoken Here.

    ERIC Educational Resources Information Center

    Frommer, Judith

    1987-01-01

    MacLang, a user-friendly authoring system for the Macintosh computer, helps second language teachers prepare and tailor computer exercises and activities; is usable with any Roman-alphabet language, Russian, and Greek; gives students intelligent feedback; and allows students to control computer activity in order to individualize learning.…

  19. Design of a 24-40 GHz balanced low noise amplifier using Lange couplers

    NASA Astrophysics Data System (ADS)

    Zongnan, Zhang; Qinghua, Huang; Mingli, Hao; Hao, Yang; Haiying, Zhang

    2009-04-01

    A wide band (24-40 GHz) fully integrated balanced low noise amplifier (LNA) using Lange couplers was designed and fabricated with a 0.15 μm pseudomorphic HEMT (pHEMT) technology. A new method to design a low-loss and high-coupling Lange coupler for wide band application in microwave frequency was also presented. This Lange coupler has a minimum loss of 0.09 dB and a maximum loss of 0.2 dB over the bandwidth from 20 to 45 GHz. The measured results show that the realized four-stage balanced LNA using this Lange coupler exhibites a noise figure (NF) of less than 2.7 dB and the maximum gain of 30 dB; moreover, a noticeably improved reflection performance is achieved. The input VSWR and the output VSWR are respectively less than 1.45 and 1.35 dB across the 24-40 GHz frequency range.

  20. Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and Fragile X syndromes.

    PubMed

    Moss, Joanna; Oliver, Chris; Nelson, Lisa; Richards, Caroline; Hall, Scott

    2013-01-01

    An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n  =  130, M age  =  17.19), Fragile X syndrome (n  =  182, M age  =  16.94), and autism spectrum disorder (n  =  142, M age  =  15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population.

  1. Analysis of Intentional Communication in Severely Handicapped Children with Cornelia-de-Lange Syndrome.

    ERIC Educational Resources Information Center

    Sarimski, Klaus

    2002-01-01

    Intentional communicative acts were assessed in 13 children (ages 2-8) with Cornelia-de-Lange syndrome with a severe mental disability and compared to children with Down and 5p syndromes. The mean number of intentional communicative acts was significantly lower. Analysis of play behaviors revealed the differences were specific for the…

  2. Facial Expression of Affect in Children with Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Collis, L.; Moss, J.; Jutley, J.; Cornish, K.; Oliver, C.

    2008-01-01

    Background: Individuals with Cornelia de Lange syndrome (CdLS) have been reported to show comparatively high levels of flat and negative affect but there have been no empirical evaluations. In this study, we use an objective measure of facial expression to compare affect in CdLS with that seen in Cri du Chat syndrome (CDC) and a group of…

  3. Self-Injurious Behavior, Self-Restraint, and Compulsive Behaviors in Cornelia de Lange Syndrome.

    ERIC Educational Resources Information Center

    Hyman, Philippa; Oliver, Chris; Hall, Scott

    2002-01-01

    Analysis of questionnaires completed by caregivers of 77 individuals with Cornelia de Lange syndrome in the United Kingdom found a significant association between self-injurious behaviors and self-restraint, and those displaying both behaviors displayed significantly more compulsions than did those not exhibiting them. Findings extend the…

  4. Facial Expression of Affect in Children with Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Collis, L.; Moss, J.; Jutley, J.; Cornish, K.; Oliver, C.

    2008-01-01

    Background: Individuals with Cornelia de Lange syndrome (CdLS) have been reported to show comparatively high levels of flat and negative affect but there have been no empirical evaluations. In this study, we use an objective measure of facial expression to compare affect in CdLS with that seen in Cri du Chat syndrome (CDC) and a group of…

  5. Health and Sleep Problems in Cornelia de Lange Syndrome: A Case Control Study

    ERIC Educational Resources Information Center

    Hall, S. S.; Arron, K.; Sloneem, J.; Oliver, C.

    2008-01-01

    Background: Self-injury, sleep problems and health problems are commonly reported in Cornelia de Lange Syndrome (CdLS) but there are no comparisons with appropriately matched participants. The relationship between these areas and comparison to a control group is warranted. Method: 54 individuals with CdLS were compared with 46 participants with…

  6. Self-Injurious Behaviour in Cornelia De Lange Syndrome: 1. Prevalence and Phenomenology

    ERIC Educational Resources Information Center

    Oliver, C.; Sloneem, J.; Hall, S.; Arron, K.

    2009-01-01

    Background: Self-injurious behaviour is frequently identified as part of the behavioural phenotype of Cornelia de Lange syndrome (CdLS). We conducted a case-control study of the prevalence and phenomenology of self-injurious behaviour (SIB) in CdLS. Methods: A total of 54 participants with CdLS were compared with 46 individuals who were comparable…

  7. Infant Attentional Behaviours as Prognostic Indicators in Cornelia-de-Lange Syndrome

    ERIC Educational Resources Information Center

    Sarimski, Klaus

    2007-01-01

    Background: Cornelia-de-Lange syndrome is a rare congenital syndrome with poor social relatedness as one of several characteristics of its behavioural phenotype. Methods: Video observations were collected from seven children in their first year of life and again with age 2-4 years. Data were analysed for distribution of object-related and social…

  8. Horizontal lang two-pencil test as a screening test for stereopsis and binocularity

    PubMed Central

    Nongpiur, Monisha E; Sharma, Pradeep

    2010-01-01

    Purpose: To assess the horizontal Lang two-pencil test as a bedside test to detect gross stereopsis. Materials and Methods: Eighty-four strabismic subjects divided into two groups based on the amount of deviation, and 40 normal subjects were studied. Sensory status examination including binocularity and stereopsis were evaluated with Bagolini, Titmus test and the Netherlands organisation for applied scientific research (TNO), Randot, synoptophore and horizontal Lang two-pencil test. Results: The subjects in the group with smaller deviation showed better performance on all the four stereo tests and over 90% demonstrated presence of fusion. When compared to TNO and Randot for determining presence of stereopsis, the horizontal Lang two-pencil test demonstrated sensitivity of 100% and 83.9%, specificity of 77.8% and 73.7%, and negative predictive value of 100% and 100% respectively. It also showed 100% specificity as a test for binocularity when compared with the Bagolini striated glass test. Conclusion: Horizontal Lang two-pencil test, an easily performed test with a high sensitivity and negative predictive value can be used as a screening test to detect gross stereopsis and binocularity. PMID:20534917

  9. Health and Sleep Problems in Cornelia de Lange Syndrome: A Case Control Study

    ERIC Educational Resources Information Center

    Hall, S. S.; Arron, K.; Sloneem, J.; Oliver, C.

    2008-01-01

    Background: Self-injury, sleep problems and health problems are commonly reported in Cornelia de Lange Syndrome (CdLS) but there are no comparisons with appropriately matched participants. The relationship between these areas and comparison to a control group is warranted. Method: 54 individuals with CdLS were compared with 46 participants with…

  10. The Behavioural Phenotype of Cornelia de Lange Syndrome: A Study of 56 Individuals

    ERIC Educational Resources Information Center

    Basile, Emanuele; Villa, L.; Selicorni, A.; Molteni, M.

    2007-01-01

    Background: Few studies have investigated functional and behavioural variables of Cornelia de Lange Syndrome (CdLS) in a large sample of individuals. The aim of this study is to provide greater insight into the clinical, behavioural and cognitive characteristics that are associated with CdLS. Methods: In total, 56 individuals with CdLS…

  11. From Tappan to Lange: Evolution of the Public Junior College Idea.

    ERIC Educational Resources Information Center

    Gallagher, Edward Arthur

    This study is a historical analysis of the public junior college idea and its emergence. The thoughts and actions of Henry P. Tappan, William W. Folwell, William R. Harper, David S. Jordan, and Alexis Lange contributed most to its origin and development. These men, products of the late nineteenth and early twentieth centuries, were strongly…

  12. Normal Language Skills and Normal Intelligence in a Child with de Lange Syndrome.

    ERIC Educational Resources Information Center

    Cameron, Thomas H.; Kelly, Desmond P.

    1988-01-01

    The subject of this case report is a two-year, seven-month-old girl with de Lange syndrome, normal intelligence, and age-appropriate language skills. She demonstrated initial delays in gross motor skills and in receptive and expressive language but responded well to intensive speech and language intervention, as well as to physical therapy.…

  13. The Varieties of Emotional Experience: A Meditation on James-Lange Theory.

    ERIC Educational Resources Information Center

    Lang, Peter J.

    1994-01-01

    This article traces the origin of the James-Lange theory of emotion, considers differences in their thinking, and assesses early criticisms and debate. Research on physiological patterns in emotion is reviewed. New paths for emotion research are outlined and homage is paid to the inspiration of William James. (SLD)

  14. Could Separate Be Equal? Helene Lange and Women's Education in Imperial Germany.

    ERIC Educational Resources Information Center

    Albisetti, James C.

    1982-01-01

    Helene Lange worked to obtain equal educational opportunities for women in Germany at the end of the nineteenth century. She tried to improve teacher training for women, enhance the curriculum in girls' high schools, and increase professional training opportunities for women. (AM)

  15. Self-Injurious Behavior, Self-Restraint, and Compulsive Behaviors in Cornelia de Lange Syndrome.

    ERIC Educational Resources Information Center

    Hyman, Philippa; Oliver, Chris; Hall, Scott

    2002-01-01

    Analysis of questionnaires completed by caregivers of 77 individuals with Cornelia de Lange syndrome in the United Kingdom found a significant association between self-injurious behaviors and self-restraint, and those displaying both behaviors displayed significantly more compulsions than did those not exhibiting them. Findings extend the…

  16. "Moving Education Forward to Keep Society Back": The South African De Lange Report Reevaluated.

    ERIC Educational Resources Information Center

    Collins, Colin B.; Gillespie, Roselyn R.

    1984-01-01

    The "De Lange Report" (1981) is the third major report on education to appear in South Africa, is by far the most comprehensive and detailed in both stated and implied assertions, poses the educational problem as technicist/manpower questions, and should be seen as part of South Africa's total strategy policy. (BRR)

  17. Analysis of Intentional Communication in Severely Handicapped Children with Cornelia-de-Lange Syndrome.

    ERIC Educational Resources Information Center

    Sarimski, Klaus

    2002-01-01

    Intentional communicative acts were assessed in 13 children (ages 2-8) with Cornelia-de-Lange syndrome with a severe mental disability and compared to children with Down and 5p syndromes. The mean number of intentional communicative acts was significantly lower. Analysis of play behaviors revealed the differences were specific for the…

  18. Infant Attentional Behaviours as Prognostic Indicators in Cornelia-de-Lange Syndrome

    ERIC Educational Resources Information Center

    Sarimski, Klaus

    2007-01-01

    Background: Cornelia-de-Lange syndrome is a rare congenital syndrome with poor social relatedness as one of several characteristics of its behavioural phenotype. Methods: Video observations were collected from seven children in their first year of life and again with age 2-4 years. Data were analysed for distribution of object-related and social…

  19. Self-Injurious Behaviour in Cornelia De Lange Syndrome: 1. Prevalence and Phenomenology

    ERIC Educational Resources Information Center

    Oliver, C.; Sloneem, J.; Hall, S.; Arron, K.

    2009-01-01

    Background: Self-injurious behaviour is frequently identified as part of the behavioural phenotype of Cornelia de Lange syndrome (CdLS). We conducted a case-control study of the prevalence and phenomenology of self-injurious behaviour (SIB) in CdLS. Methods: A total of 54 participants with CdLS were compared with 46 individuals who were comparable…

  20. Precision Astrometry with SIM PlanetQuest: Science and Mission Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael; Unwin, Stephen

    2006-01-01

    This viewgraph presentation gives a science and mission update of precision Astrometry with the Space Interferometry Mission (SIM) PlanetQuest. The topics include: 1) SIM PlanetQuest - the World s First Long- Baseline Optical Interferometer in Space; 2) National Academy of Sciences / NRC endorses SIM PlanetQuest; 3) Astrometry with an Interferometer; 4) Overall Configuration (deployed); 5) SIM Planet Finding Capabilities; 6) Planet detection with SIM - minimum masses; 7) Searching for Terrestrial Planets with SIM; 8) Planets around Young Stars; 9) SIM PlanetQuest Science Team; 10) SIM Astrophysics; 11) SIM's Reach Extends Across our Entire Galaxy to do Precision Astrophysics; 12) Dynamics of Galaxy Groups within 5 Mpc; 13) Galactic tidal tails; 14) Dark Halo of our Galaxy; 15) Probing Active Galactic Nuclei with Astrometry; 16) Sample tile for relative astrometry; 17) Astrometric signatures of AGN; 18) Snapshot Observing Mode: Astrometry for the masses; and 19) SIM Technology Development is Complete.

  1. Prenatal/neonatal pathology in two cases of Cornelia de Lange syndrome harboring novel mutations of NIPBL.

    PubMed

    Lalatta, Faustina; Russo, Silvia; Gentilin, Barbara; Spaccini, Luigina; Boschetto, Chiara; Cavalleri, Florinda; Masciadri, Maura; Gervasini, Cristina; Bentivegna, Angela; Castronovo, Paola; Larizza, Lidia

    2007-03-01

    This study reviews prenatal findings in two cases with a suspected diagnosis of Cornelia de Lange Syndrome, a multisystem disorder characterized by somatic defects and mental retardation, that were later confirmed by postmortem examination and molecular testing. Although the correlation between the Cornelia de Lange Syndrome genotype and phenotype is still unclear, preliminary data indicate several severe phenotypic features that are likely to be detected prenatally in NIPBL-mutated patients. We report on two prenatal/neonatal cases with unusual pathologic findings indicating Cornelia de Lange Syndrome. The first, with suspected Cornelia de Lange Syndrome after a set of typical dysmorphisms was noted by prenatal ultrasound, was confirmed by a physical examination after termination of the pregnancy. The second was diagnosed neonatally on the basis of typical clinical signs. Medical complications led to death within the first month of life. Molecular analysis of NIPBL, the gene that codes for delangin (a component of the cohesin complex), performed postnatally detected two de novo mutations: a missense change (P2056L) in a highly conserved residue and a nonsense alteration (S2490 replaced by a stop codon). We suggest that early diagnosis of Cornelia de Lange Syndrome would be made much easier by the assemblage of a set of prenatal diagnostic features and criteria in Cornelia de Lange Syndrome cases that have been confirmed by direct physical and molecular examinations. We also suggest that Cornelia de Lange Syndrome genotype-phenotype correlations need to be extended to prenatal cases.

  2. TOF SIMS characterization of SEI layer on battery electrodes

    NASA Astrophysics Data System (ADS)

    Veryovkin, I. V.; Tripa, C. E.; Zinovev, A. V.; Baryshev, S. V.; Li, Y.; Abraham, D. P.

    2014-08-01

    In the last decade, many studies applied surface analysis techniques (SEM, XPS and SIMS) to understand the formation of SEI layers on Li-ion battery electrodes. This work was meant as a comparative model study of the SEI layer formation, which combined in situ SEM imaging with TOF SIMS depth profiling of four samples of the same graphite electrode material, which was subjected to different charge-discharge cycling schemes in a Li-ion battery. Besides comparing compositions of sub-surface regions of these differently processed electrodes, we wanted to know whether these compositions depend on after-cycling sample preparation, in particular if a brief exposure of these samples to air would affect the compositions measured by TOF SIMS. We found that the exposure to air (1) increases secondary ion yield for all species, and (2) changes shapes of SIMS depth profiles for some key species. For selected samples, we also conducted a comparison between the conventional single beam TOF-SIMS depth profiling and a high resolution dual beam depth profiling and found that the former approach can detect the same features in depth profiles as the latter one. We interpreted this as an indication that the sample surface morphology (high roughness) could be a limiting factor in this SEI study, suggesting that specially designed model samples with smooth surfaces are a better choice for future studies.

  3. SIMS: addressing the problem of heterogeneity in databases

    NASA Astrophysics Data System (ADS)

    Arens, Yigal

    1997-02-01

    The heterogeneity of remotely accessible databases -- with respect to contents, query language, semantics, organization, etc. -- presents serious obstacles to convenient querying. The SIMS (single interface to multiple sources) system addresses this global integration problem. It does so by defining a single language for describing the domain about which information is stored in the databases and using this language as the query language. Each database to which SIMS is to provide access is modeled using this language. The model describes a database's contents, organization, and other relevant features. SIMS uses these models, together with a planning system drawing on techniques from artificial intelligence, to decompose a given user's high-level query into a series of queries against the databases and other data manipulation steps. The retrieval plan is constructed so as to minimize data movement over the network and maximize parallelism to increase execution speed. SIMS can recover from network failures during plan execution by obtaining data from alternate sources, when possible. SIMS has been demonstrated in the domains of medical informatics and logistics, using real databases.

  4. Proposed Ice Flow, Given 200m and 400m Additional Ice in the Allan Hills Region, Antarctica: Implications for Meteorite Concentration

    NASA Astrophysics Data System (ADS)

    Traub-Metlay, S.; Cassidy, W. A.

    1992-07-01

    The Allan Hills-David Glacier region contains some of the most highly populated meteorite stranding surfaces in Antarctica. Nearly 2000 meteorites have to date been collected from the icefields associated with the Allan Hills, and nearly 1500 from areas around Elephant Moraine. While much attention has been focused on the current geological and glaciological conditions of these stranding surfaces, less work has been done concerning what they may have looked like in the past, when ice thicknesses may have been greater. In this study, conjectural maps of the current Allan Hills area with 200 meters and 400 meters of additional ice cover each are analyzed for probable regional and local ice flow patterns. A dramatic decrease in ice thickness over a relatively brief period of time could result either from climatic change or a geologically rapid regional uplift. Delisle and Sievers (1991) noted that the valley between the Allan Hills Main Icefield and the Allan Hills resembles a half-graben resulting from east-west extensional tectonics, and that the mesa-like bedrock features associated with the Near Western and Mid Western Icefields resemble fault blocks. They concluded that the Allan Hills area icefields may have become active stranding surfaces as a result of a regional uplift within the past 1-2 million years, assuming a current rate of uplift in the Allan Hills region of ~100 meters/million years. Whether the cause was climatic or tectonic, generalized maps of current ice contours plus 400 and 200 meters ice may provide views of what the Allan Hills region looked like just before activation of the modern meteorite stranding surfaces (Figs. 1 and 2). At an ice thickness greater by 400 meters, ice could flow smoothly over the Allan Hills and would drain down to the Mawson Glacier via the Odell Glacier, east of the Allan Hills; down the Manhaul Bay depression between the east and west arms of Allan Hills; and down the half-graben discovered by Delisle and Sievers

  5. Novel SLC16A2 mutations in patients with Allan-Herndon-Dudley syndrome

    PubMed Central

    Shimojima, Keiko; Maruyama, Koichi; Kikuchi, Masahiro; Imai, Ayako; Inoue, Ken; Yamamoto, Toshiyuki

    2016-01-01

    Summary Allan-Herndon-Dudley syndrome (AHDS) is an X-linked disorder caused by impaired thyroid hormone transporter. Patients with AHDS usually exhibit severe motor developmental delay, delayed myelination of the brain white matter, and elevated T3 levels in thyroid tests. Neurological examination of two patients with neurodevelopmental delay revealed generalized hypotonia, and not paresis, as the main neurological finding. Nystagmus and dyskinesia were not observed. Brain magnetic resonance imaging demonstrated delayed myelination in early childhood in both patients. Nevertheless, matured myelination was observed at 6 years of age in one patient. Although the key finding for AHDS is elevated free T3, one of the patients showed a normal T3 level in childhood, misleading the diagnosis of AHDS. Genetic analysis revealed two novel SLC16A2 mutations, p.(Gly122Val) and p.(Gly221Ser), confirming the AHDS diagnosis. These results indicate that AHDS diagnosis is sometimes challenging owing to clinical variability among patients. PMID:27672545

  6. THE DEAD-LIVING-MOTHER: MARIE BONAPARTE'S INTERPRETATION OF EDGAR ALLAN POE'S SHORT STORIES.

    PubMed

    Obaid, Francisco Pizarro

    2016-06-01

    Princess Marie Bonaparte is an important figure in the history of psychoanalysis, remembered for her crucial role in arranging Freud's escape to safety in London from Nazi Vienna, in 1938. This paper connects us to Bonaparte's work on Poe's short stories. Founded on concepts of Freudian theory and an exhaustive review of the biographical facts, Marie Bonaparte concluded that the works of Edgar Allan Poe drew their most powerful inspirational force from the psychological consequences of the early death of the poet's mother. In Bonaparte's approach, which was powerfully influenced by her recognition of the impact of the death of her own mother when she was born-an understanding she gained in her analysis with Freud-the thesis of the dead-living-mother achieved the status of a paradigmatic key to analyze and understand Poe's literary legacy. This paper explores the background and support of this hypothesis and reviews Bonaparte's interpretation of Poe's most notable short stories, in which extraordinary female figures feature in the narrative.

  7. A legacy in 20th-century medicine: Robert Allan Phillips and the taming of cholera.

    PubMed

    Savarino, Stephen J

    2002-09-15

    The legacy of Captain Robert Allan Phillips (1906-1976) was to establish effective, evidence-based rehydration methods for the treatment of cholera. As a Navy Lieutenant at the Rockefeller Institute for Medical Research (New York, New York) during World War II, Phillips developed a field method for the rapid assessment of fluid loss in wounded servicemen. After the war, he championed the establishment of United States Naval Medical Research Unit (NAMRU)-3 (Cairo; 1946) and NAMRU-2 (Taipei; 1955), serving at the helm of both units. Phillips embarked on cholera studies during the 1947 Egyptian cholera epidemic and brought them to maturity at NAMRU-2 (1958-1965), elucidating the pathophysiologic derangements induced by cholera and developing highly efficacious methods of intravenous rehydration. His conception of a simpler cholera treatment was realized in the late 1960s with the development of glucose-based oral rehydration therapy, a monumental breakthrough to which many other investigators made vital contributions. Today, these simple advances have been integrated into everyday medical practice across the globe, saving millions of lives annually.

  8. Observation, Inference, and Imagination: Elements of Edgar Allan Poe's Philosophy of Science

    NASA Astrophysics Data System (ADS)

    Gelfert, Axel

    2014-03-01

    Edgar Allan Poe's standing as a literary figure, who drew on (and sometimes dabbled in) the scientific debates of his time, makes him an intriguing character for any exploration of the historical interrelationship between science, literature and philosophy. His sprawling `prose-poem' Eureka (1848), in particular, has sometimes been scrutinized for anticipations of later scientific developments. By contrast, the present paper argues that it should be understood as a contribution to the raging debates about scientific methodology at the time. This methodological interest, which is echoed in Poe's `tales of ratiocination', gives rise to a proposed new mode of—broadly abductive—inference, which Poe attributes to the hybrid figure of the `poet-mathematician'. Without creative imagination and intuition, Science would necessarily remain incomplete, even by its own standards. This concern with imaginative (abductive) inference ties in nicely with his coherentism, which grants pride of place to the twin virtues of Simplicity and Consistency, which must constrain imagination lest it degenerate into mere fancy.

  9. Atmospheric composition 1 million years ago from blue ice in the Allan Hills, Antarctica

    PubMed Central

    Higgins, John A.; Kurbatov, Andrei V.; Spaulding, Nicole E.; Brook, Ed; Introne, Douglas S.; Chimiak, Laura M.; Yan, Yuzhen; Mayewski, Paul A.; Bender, Michael L.

    2015-01-01

    Here, we present direct measurements of atmospheric composition and Antarctic climate from the mid-Pleistocene (∼1 Ma) from ice cores drilled in the Allan Hills blue ice area, Antarctica. The 1-Ma ice is dated from the deficit in 40Ar relative to the modern atmosphere and is present as a stratigraphically disturbed 12-m section at the base of a 126-m ice core. The 1-Ma ice appears to represent most of the amplitude of contemporaneous climate cycles and CO2 and CH4 concentrations in the ice range from 221 to 277 ppm and 411 to 569 parts per billion (ppb), respectively. These concentrations, together with measured δD of the ice, are at the warm end of the field for glacial–interglacial cycles of the last 800 ky and span only about one-half of the range. The highest CO2 values in the 1-Ma ice fall within the range of interglacial values of the last 400 ka but are up to 7 ppm higher than any interglacial values between 450 and 800 ka. The lowest CO2 values are 30 ppm higher than during any glacial period between 450 and 800 ka. This study shows that the coupling of Antarctic temperature and atmospheric CO2 extended into the mid-Pleistocene and demonstrates the feasibility of discontinuously extending the current ice core record beyond 800 ka by shallow coring in Antarctic blue ice areas. PMID:25964367

  10. Twenty-Five Years of Applications of the Modified Allan Variance in Telecommunications.

    PubMed

    Bregni, Stefano

    2016-04-01

    The Modified Allan Variance (MAVAR) was originally defined in 1981 for measuring frequency stability in precision oscillators. Due to its outstanding accuracy in discriminating power-law noise, it attracted significant interest among telecommunications engineers since the early 1990s, when it was approved as a standard measure in international standards, redressed as Time Variance (TVAR), for specifying the time stability of network synchronization signals and of equipment clocks. A dozen years later, the usage of MAVAR was also introduced for Internet traffic analysis to estimate self-similarity and long-range dependence. Further, in this field, it demonstrated superior accuracy and sensitivity, better than most popular tools already in use. This paper surveys the last 25 years of progress in extending the field of application of the MAVAR in telecommunications. First, the rationale and principles of the MAVAR are briefly summarized. Its adaptation as TVAR for specification of timing stability is presented. The usage of MAVAR/TVAR in telecommunications standards is reviewed. Examples of measurements on real telecommunications equipment clocks are presented, providing an overview on their actual performance in terms of MAVAR. Moreover, applications of MAVAR to network traffic analysis are surveyed. The superior accuracy of MAVAR in estimating long-range dependence is emphasized by highlighting some remarkable practical examples of real network traffic analysis.

  11. Atmospheric composition 1 million years ago from blue ice in the Allan Hills, Antarctica.

    PubMed

    Higgins, John A; Kurbatov, Andrei V; Spaulding, Nicole E; Brook, Ed; Introne, Douglas S; Chimiak, Laura M; Yan, Yuzhen; Mayewski, Paul A; Bender, Michael L

    2015-06-02

    Here, we present direct measurements of atmospheric composition and Antarctic climate from the mid-Pleistocene (∼1 Ma) from ice cores drilled in the Allan Hills blue ice area, Antarctica. The 1-Ma ice is dated from the deficit in (40)Ar relative to the modern atmosphere and is present as a stratigraphically disturbed 12-m section at the base of a 126-m ice core. The 1-Ma ice appears to represent most of the amplitude of contemporaneous climate cycles and CO2 and CH4 concentrations in the ice range from 221 to 277 ppm and 411 to 569 parts per billion (ppb), respectively. These concentrations, together with measured δD of the ice, are at the warm end of the field for glacial-interglacial cycles of the last 800 ky and span only about one-half of the range. The highest CO2 values in the 1-Ma ice fall within the range of interglacial values of the last 400 ka but are up to 7 ppm higher than any interglacial values between 450 and 800 ka. The lowest CO2 values are 30 ppm higher than during any glacial period between 450 and 800 ka. This study shows that the coupling of Antarctic temperature and atmospheric CO2 extended into the mid-Pleistocene and demonstrates the feasibility of discontinuously extending the current ice core record beyond 800 ka by shallow coring in Antarctic blue ice areas.

  12. The Allan Burns mummies: A history and future prospect of an anatomical collection.

    PubMed

    Lee, J; Štrkalj, G

    2017-08-31

    Acquiring adequate resources for anatomy education has represented a challenge throughout the discipline's long history. A significant number of collections housed in anatomy departments contain human tissue of unknown provenance with some obtained in morally dubious ways. This paper outlines the history and future prospects of one such anatomical assemblage - the Burns Anatomical Collection, currently housed at the University of Maryland (UM). The collection originally contained more than 1000 anatomically prepared mummified human remains. They were produced by the renowned Scottish anatomist Allan Burns in Glasgow in the late eighteenth and early nineteenth centuries. The prepared cadavers became a commodity and after Burns' death, were acquired by his pupil Granville Pattison, who later sold them to the UM. While the origin of these human remains is unknown, historical data suggests that most of the cadavers for the collection were obtained through grave robbing. While intensely used in anatomy teaching in the nineteenth century, specimens from the collection should now be treated primarily as historical artifacts, appropriate only for teaching medical history and ethics. Other perspectives may include repatriating and reburying the human remains and providing a memorial service. Most importantly, this collection and others similar to it should initiate dialog and reflection on the ethical aspects of the past and present medical practice.

  13. Metal with anomalously low Ni and Ge concentrations in the Allan Hills A77081 winonaite

    NASA Technical Reports Server (NTRS)

    Kracher, Alfred

    1988-01-01

    The Ge content of metal in the Allan Hills A77081 winonaite was determined by high-sensitivity electron microprobe analysis. By optimizing analytical conditions for Ge determination, a detection limit of about 75 ppm could be achieved. In A77081 some small kamacite grains contain less Ni and Ge and more Co than coarse-grained metal. These small grains are always associated with sulfide, raising the possibility that anomalous metal is related to eutectic melting. However, when published partition coefficients for Ni and Ge in the Fe-Ni-S system are used to model fractionation of these elements during eutectic melting, one finds that secondary metal should be enriched in Ni and depleted in Ge. Thus, the positive Ni-Ge correlation found in this study is the opposite of the expected trend. No explanation for this discrepancy has yet been found. Nonetheless, the existence of anomalous metal is an indication that A77081, and probably other winonaites as well, have undergone some fractionation. This supports the notion that the high-temperature history of winonaites is related to the formation of IAB iron meteorites, whose silicate inclusions are very similar to winonaites.

  14. Application of the Allan Variance to Time Series Analysis in Astrometry and Geodesy: A Review.

    PubMed

    Malkin, Zinovy

    2016-04-01

    The Allan variance (AVAR) was introduced 50 years ago as a statistical tool for assessing the frequency standards deviations. For the past decades, AVAR has increasingly been used in geodesy and astrometry to assess the noise characteristics in geodetic and astrometric time series. A specific feature of astrometric and geodetic measurements, as compared with clock measurements, is that they are generally associated with uncertainties; thus, an appropriate weighting should be applied during data analysis. In addition, some physically connected scalar time series naturally form series of multidimensional vectors. For example, three station coordinates time series X, Y, and Z can be combined to analyze 3-D station position variations. The classical AVAR is not intended for processing unevenly weighted and/or multidimensional data. Therefore, AVAR modifications, namely weighted AVAR (WAVAR), multidimensional AVAR (MAVAR), and weighted multidimensional AVAR (WMAVAR), were introduced to overcome these deficiencies. In this paper, a brief review is given of the experience of using AVAR and its modifications in processing astrogeodetic time series.

  15. SIMS analysis of extended impact features on LDEF experiment

    NASA Technical Reports Server (NTRS)

    Amari, S.; Foote, J.; Jessberger, E. K.; Simon, C.; Stadermann, F. J.; Swan, P.; Walker, R.; Zinner, E.

    1991-01-01

    Discussed here are the first Secondary Ion Mass Spectroscopy (SIMS) analysis of projectile material deposited in extended impact features on Ge wafers from the trailing edge. Although most capture cells lost their plastic film covers, they contain extended impact features that apparently were produced by high velocity impacts when the plastic foils were still intact. Detailed optical scanning of all bare capture cells from the trailing edge revealed more than 100 impacts. Fifty-eight were selected by scanning electron microscope (SEM) inspection as prime candidates for SIMS analysis. Preliminary SIMS measurements were made on 15 impacts. More than half showed substantial enhancements of Mg, Al, Si, Ca, and Fe in the impact region, indicating micrometeorites as the projectiles.

  16. SIMS analysis of extended impact features on LDEF experiment

    NASA Technical Reports Server (NTRS)

    Amari, S.; Foote, J.; Jessberger, E. K.; Simon, C.; Stadermann, F. J.; Swan, P.; Walker, R.; Zinner, E.

    1991-01-01

    Discussed here are the first Secondary Ion Mass Spectroscopy (SIMS) analysis of projectile material deposited in extended impact features on Ge wafers from the trailing edge. Although most capture cells lost their plastic film covers, they contain extended impact features that apparently were produced by high velocity impacts when the plastic foils were still intact. Detailed optical scanning of all bare capture cells from the trailing edge revealed more than 100 impacts. Fifty-eight were selected by scanning electron microscope (SEM) inspection as prime candidates for SIMS analysis. Preliminary SIMS measurements were made on 15 impacts. More than half showed substantial enhancements of Mg, Al, Si, Ca, and Fe in the impact region, indicating micrometeorites as the projectiles.

  17. xSim: The Extreme-Scale Simulator

    SciTech Connect

    Boehm, Swen; Engelmann, Christian

    2011-01-01

    Investigating parallel application performance properties at scale is becoming an important part of high-performance computing (HPC) application development and deployment. The Extreme-scale Simulator (xSim) is a performance investigation toolkit that permits running an application in a controlled environment at extreme scale without the need for a respective extreme-scale HPC system. Using a lightweight parallel discrete event simulation, xSim executes a parallel application with a virtual wall clock time, such that performance data can be extracted based on a processor model and a network model. This paper presents significant enhancements to the xSim toolkit prototype that provide a more complete Message Passing Interface (MPI) support and improve its versatility. These enhancements include full virtual MPI group, communicator and collective communication support, and global variables support. The new capabilities are demonstrated by executing the entire NAS Parallel Benchmark suite in a simulated HPC environment.

  18. RxnSim: a tool to compare biochemical reactions.

    PubMed

    Giri, Varun; Sivakumar, Tadi Venkata; Cho, Kwang Myung; Kim, Tae Yong; Bhaduri, Anirban

    2015-11-15

    : Quantitative assessment of chemical reaction similarity aids database searches, classification of reactions and identification of candidate enzymes. Most methods evaluate reaction similarity based on chemical transformation patterns. We describe a tool, RxnSim, which computes reaction similarity based on the molecular signatures of participating molecules. The tool is able to compare reactions based on similarities of substrates and products in addition to their transformation. It allows masking of user-defined chemical moieties for weighted similarity computations. RxnSim is implemented in R and is freely available from the Comprehensive R Archive Network, CRAN (http://cran.r-project.org/web/packages/RxnSim/). anirban.b@samsung.com or ty76.kim@samsung.com Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. The Ankara Mélange: an indicator of Tethyan evolution of Anatolia

    NASA Astrophysics Data System (ADS)

    Çakir, Üner; Üner, Tijen

    2016-08-01

    The Ankara Mélange is a complex formed by imbricated slices of limestone block mélanges (Karakaya and Hisarlıkaya Formations), Neotethyan ophiolites (Eldivan, Ahlat and Edige ophiolites), post-ophiolitic cover units (Mart and Kavak formations) and Tectonic Mélange Unit (Hisarköy Formation or Dereköy Mélange). The Karakaya and Hisarlıkaya formations are roughly similar and consist mainly of limestone block mélange. Nevertheless, they represent some important geological differences indicating different geological evolution. Consequently, the Karakaya and Hisarlıkaya formations are interpreted as Eurasian and Gondwanian marginal units formed by fragmentation of the Gondwanian carbonate platform during the continental rifting of the Neotethys in the Middle Triassic time. During the latest Triassic, Neotethyan lithosphere began to subduct beneath the Eurasian continent and caused intense deformation of the marginal units. The Eldivan, Ahlat and Edige ophiolites represent different fragments of the Neotethyan oceanic lithosphere emplaced onto the Gondwanian margin during the Albian-Aptian, middle Turonian and middle Campanian, respectively. The Eldivan Ophiolite is a NE-SW trending and a nearly complete assemblage composed, from bottom to top, of a volcanic-sedimentary unit, a metamorphic unit, peridotite tectonites, cumulates and sheeted dykes. The Eldivan Ophiolite is unconformably covered by Cenomanian-Lower Turonian sedimentary unit. The Eldivan Ophiolite is overthrust by the Ahlat Ophiolite in the north and Edige Ophiolite in the west. The Ahlat ophiolite is an east-west oriented assemblage comprised of volcanic-sedimentary unit, metamorphic unit, peridotite tectonites and cumulates. The Edige Ophiolite consists of a volcanic-sedimentary unit, peridotite tectonites, dunite, wherlite, pyroxenite and gabbro cumulates. The Tectonic Mélange Unit is a chaotic formation of various blocks derived from ophiolites, from the Karakaya and Hisarlıkaya formations and

  20. De Lange syndrome: subjective and objective comparison of the classical and mild phenotypes.

    PubMed Central

    Allanson, J E; Hennekam, R C; Ireland, M

    1997-01-01

    Classical de Lange syndrome presents with a striking face, pronounced growth and mental retardation, and variable limb deficiencies. Over the past five years, a mild variant has been defined, with less significant psychomotor retardation, less marked pre- and postnatal growth deficiency, and an uncommon association with major malformations, although mild limb anomalies may be present. We have evaluated 43 subjects with de Lange syndrome, 30 with classical features, aged from birth to 21 years, and 13 with the mild phenotype, aged from 18 months to 30 years. In addition to assessment of gestalt and facial change with time, detailed craniofacial measurements have been obtained on each subject and composite pattern profiles compiled. The characteristic face of classical de Lange syndrome is present at birth and changes little throughout life, although there is some lengthening of the face with age and the jaw becomes squared. In mild de Lange syndrome, the characteristic classical appearance may be present at birth, but in some subjects it may be two or three years before the typical face is obvious. In general, the overall impression is less striking, perhaps because of increased facial expression and greater alertness. With age, the face loses the characteristic appearance, the nasal height increases, the philtrum does not seem as long, and the upper vermilion is full and everted, although the crescent shaped mouth with downturned corners remains. Eyebrows may be full and bushy. Objective comparison of the face in mild and classical de Lange syndrome, through the use of craniofacial pattern profiles, shows marked similarity of patterns at 4 to 9 years; both groups have microbrachycephaly, but the individual dimensions of the mild group are slightly closer to normal than their classical counterparts. The correlation coefficient is high (0.83). In the adult groups, similarity of patterns remains but is less marked. The normalisation of scores in the mild group is more

  1. VentSim: a simulation model of cardiopulmonary physiology.

    PubMed

    Rutledge, G W

    1994-01-01

    VentSim is a quantitative model that predicts the effects of alternative ventilator settings on the cardiopulmonary physiology of critically ill patients. VentSim is an expanded version of the physiologic model in VentPlan, an application that provides ventilator-setting recommendations for patients in the intensive care unit. VentSim includes a ventilator component, an airway component, and a circulation component. The ventilator component predicts the pressures and airflows that are generated by a volume-cycled, constant-flow ventilator. The airway component has anatomic and physiologic deadspace compartments, and two alveolar compartments that participate in gas exchange with two pulmonary blood-flow compartments in the circulatory component. The circulatory component also has a shunt compartment that allows a fraction of blood flow to bypass gas exchange in the lungs, and a tissue compartment that consumes oxygen and generates carbon dioxide. The VentSim model is a set of linked first-order difference equations, with control variables that correspond to the ventilator settings, dependent variables that correspond to the physiologic state, and one independent variable, time. Because the model has no steady state solution, VentSim solves the equations by numeric integration, which is computation intensive. Simulation results demonstrate that VentSim predicts the effects of a variety of physiologic abnormalities that cannot be represented in less complex models such as the VentPlan model. For a ventilator-management application, the time-critical nature of ventilator-setting decisions limits the use of complex models. Advanced ventilator-management applications may include a mechanism to select patient-specific models that balance the trade-off of benefit of model detail and cost of computation delay.

  2. Virus and Bacterial Cell Chemical Analysis by NanoSIMS

    SciTech Connect

    Weber, P; Holt, J

    2008-07-28

    In past work for the Department of Homeland Security, the LLNL NanoSIMS team has succeeded in extracting quantitative elemental composition at sub-micron resolution from bacterial spores using nanometer-scale secondary ion mass spectrometry (NanoSIMS). The purpose of this task is to test our NanoSIMS capabilities on viruses and bacterial cells. This initial work has proven successful. We imaged Tobacco Mosaic Virus (TMV) and Bacillus anthracis Sterne cells using scanning electron microscopy (SEM) and then analyzed those samples by NanoSIMS. We were able resolve individual viral particles ({approx}18 nm by 300 nm) in the SEM and extract correlated elemental composition in the NanoSIMS. The phosphorous/carbon ratio observed in TMV is comparable to that seen in bacterial spores (0.033), as was the chlorine/carbon ratio (0.11). TMV elemental composition is consistent from spot to spot, and TMV is readily distinguished from debris by NanoSIMS analysis. Bacterial cells were readily identified in the SEM and relocated in the NanoSIMS for elemental analysis. The Ba Sterne cells were observed to have a measurably lower phosphorous/carbon ratio (0.005), as compared to the spores produced in the same run (0.02). The chlorine/carbon ratio was approximately 2.5X larger in the cells (0.2) versus the spores (0.08), while the fluorine/carbon ratio was approximately 10X lower in the cells (0.008) than the spores (0.08). Silicon/carbon ratios for both cells and spores encompassed a comparable range. The initial data in this study suggest that high resolution analysis is useful because it allows the target agent to be analyzed separate from particulates and other debris. High resolution analysis would also be useful for trace sample analysis. The next step in this work is to determine the potential utility of elemental signatures in these kinds of samples. We recommend bulk analyses of media and agent samples to determine the range of media compositions in use, and to determine how

  3. NetSim Project contributions to ns-3

    SciTech Connect

    2012-05-01

    ns-3 is an external (non-LLNL) open-source framework for modeling computer networks. The LLNL NetSim project uses the ns-3 framework to address specific questions in computer network design, operation, and security. As part of the NetSim work, we develop bug fixes, deature enhancements, and new capabilities for the ns-3 framework. The virtual package referenced here, ns-3-contrib, consists of those developments we have (or will) contribute back to the ns-3 project in source code form, for inclusion in future releases of ns-3.

  4. A case of third trimester diagnosis of Cornelia de Lange syndrome.

    PubMed

    Kanellopoulos, V; Iavazzo, C; Tzanatou, C; Papadakis, E; Tassis, K

    2011-01-01

    The objective is to present a rare case of late diagnosis of Cornelia de Lange syndrome. A 27-year-old pregnant woman (gravida 1, para 0) was referred to our Fetal Medicine Department during her 33rd week of gestation due to intrauterine growth restriction (IUGR) and polyhydramnios. The ultrasound scanning confirmed the findings and furthermore, the 3-D examination revealed minor facial dysmorphisms, limb abnormalities, and hypertrichosis. The fetus died 1 week post-diagnosis due to unknown reason and the woman underwent an induction of labor. Postmortem examination confirmed the diagnosis of Cornelia de Lange syndrome. The prognosis of the syndrome is severe. Termination of pregnancy before viability is proposed. Genetic counseling is necessary.

  5. Effects of herbicides on Behr's metalmark butterfly, a surrogate species for the endangered butterfly, Lange's metalmark.

    PubMed

    Stark, John D; Chen, Xue Dong; Johnson, Catherine S

    2012-05-01

    Lange's metalmark butterfly, Apodemia mormo langei Comstock, is in danger of extinction due to loss of habitat caused by invasive exotic plants which are eliminating its food, naked stem buckwheat. Herbicides are being used to remove invasive weeds from the dunes; however, little is known about the potential effects of herbicides on butterflies. To address this concern we evaluated potential toxic effects of three herbicides on Behr's metalmark, a close relative of Lange's metalmark. First instars were exposed to recommended field rates of triclopyr, sethoxydim, and imazapyr. Life history parameters were recorded after exposure. These herbicides reduced the number of adults that emerged from pupation (24-36%). Each herbicide has a different mode of action. Therefore, we speculate that effects are due to inert ingredients or indirect effects on food plant quality. If these herbicides act the same in A. mormo langei, they may contribute to the decline of this species.

  6. Relating syntax and semantics: the syntactico-semantic lexicon of the system VIE-LANG

    SciTech Connect

    Steinacker, I.; Buchberger, E.

    1983-01-01

    This paper describes the structure and evaluation of the syntactico-semantic lexicon (SSL) of the German natural language understanding system VIE-LANG. VIE-LANG uses an si-net as internal representation. The SSL contains the rules according to which the mapping between net-structures and surface structures of a sentence is carried out. This information is structured in a way that it can be evaluated from two sides. The parser interprets it as production-rules that control the analysis. Syntactic and semantic features of the input sentence and evaluated and individuals are created in the semantic net. The generator uses the same rules to express selected net-structures in adequate natural language expressions. It is shown who both processes can make effective use of the SSL. The different possibilities for evaluating the SSL are explained and illustrated by examples. 12 references.

  7. Aesthetic and functional management of a patient with Cornelia de Lange syndrome

    PubMed Central

    Johns, Dexton Antony; Bhonsale, Dnyanesh L.; Shivashanker, V. Y.; Johns, Manu

    2012-01-01

    Cornelia de Lange syndrome is a syndrome of multiple congenital anomalies. The genetic and molecular bases of these lesions are not clear. It is divided into three types based on the severity of the anomaly. Dental findings revealed contracted maxilla, malaligned teeth, multiple impacted and missing teeth. This article describes the successful management of upper central incisor with lateral opening in the apical third on the mesial surface of the root along with aesthetic and functional rehabilitation. PMID:22629076

  8. Cervical spine malformation in cornelia de lange syndrome: a report of three patients.

    PubMed

    Bettini, Laura Rachele; Locatelli, Laura; Mariani, Milena; Cianci, Paola; Giussani, Carlo; Canonico, Francesco; Cereda, Anna; Russo, Silvia; Gervasini, Cristina; Biondi, Andrea; Selicorni, Angelo

    2014-06-01

    Cornelia de Lange syndrome (CdLS) is a complex genetic disease with skeletal involvement mostly related to upper limb malformations. We report on three males with clinical and molecular diagnoses of CdLS. Besides typical CdLS features, all showed different cervical spine malformations. To the best of our knowledge, this is an unusual malformation in the CdLS phenotypic spectrum. © 2014 Wiley Periodicals, Inc.

  9. Self-Injurious Behaviour in Cornelia De Lange Syndrome: 2. Association with Environmental Events

    ERIC Educational Resources Information Center

    Sloneem, J.; Arron, K.; Hall, S. S.; Oliver, C.

    2009-01-01

    Background: Self-injurious behaviour is commonly seen in Cornelia de Lange syndrome (CdLS). However, there has been limited research into the aetiology of self-injury in CdLS and whether environmental factors influence the behaviour. Methods: We observed the self-injury of 27 individuals with CdLS and 17 participants who did not have CdLS matched…

  10. Assessment of adult stereopsis using the Lang 1 Stereotest: a pilot study.

    PubMed

    Brown, S; Weih, L; Mukesh, N; McCarty, C; Taylor, H

    2001-01-01

    To assess the use of the Lang 1 Stereotest as a vision-screening test for adults, for which little is known or reported. The Lang 1 Stereotest was administered to 292 consecutive participants of the Visual Impairment Project (VIP) five year followup study, which is a population based study of eye disease in Melbourne, Australia. 56.9% were female. The mean age was 59.4 years, range 44-90 years. A "positive" stereoscopic response was recorded where the stereoscopic target image was correctly named; a "partial positive" response where depth was appreciated but the shape could not be named; and a "negative" response where there was no appreciation of a stereo effect. The responses were further categorized so that the test was either "passed" or "failed". A "pass" score was 3/3 positive responses; 3/3 partial positive responses or 2/3 positive and/or partial positive responses where the negative response was at the 550" of arc stereoacuity level. "Failure" was 3/3 negative responses and 2/3 negative responses where the positive or partial positive response as at the 1200" level. Of the 292 participants tested, 19 (6.5%) participants "failed" the test. In addition to strabismus and anisometropia, failure was associated significantly (p<0.001) with reduced distance visual acuity (<6/12) irrespective of the ocular morbidity. The Lang 1 Stereotest correctly identified people with vision defects associated with reduced stereopsis. This suggests the Lang 1 Stereotest is an appropriate for the vision screening of adults as it is for children.

  11. Self-Injurious Behaviour in Cornelia De Lange Syndrome: 2. Association with Environmental Events

    ERIC Educational Resources Information Center

    Sloneem, J.; Arron, K.; Hall, S. S.; Oliver, C.

    2009-01-01

    Background: Self-injurious behaviour is commonly seen in Cornelia de Lange syndrome (CdLS). However, there has been limited research into the aetiology of self-injury in CdLS and whether environmental factors influence the behaviour. Methods: We observed the self-injury of 27 individuals with CdLS and 17 participants who did not have CdLS matched…

  12. Relationship between magnetic fabrics and shear directions in mélange within the Miyama Formation, Shimanto accretionary complex, Japan

    NASA Astrophysics Data System (ADS)

    Tokiwa, Tetsuya; Yamamoto, Yuzuru

    2012-09-01

    The magnetic fabrics of tectonic mélange in the Miyama Formation, Shimanto accretionary complex of Kii Peninsula, Japan, are examined using anisotropy of magnetic susceptibility (AMS) data, and they are compared with shear directions estimated by traditional measurements of P-Y intersections in the mélange. In most cases, AMS data are consistent with the estimated shear directions, and they can be divided into two types: one with Kmax (the maximum magnetic susceptibility) axes oriented parallel to the shear direction on the shear planes, and another with Kmax axes oriented parallel to the P-Y intersections. In both types, the Kmin (the minimum magnetic susceptibility) axes are oriented perpendicular to the mélange foliation. However, some sites exhibit unexpected Kmax axes orientations trending perpendicular to the mélange foliation. Analyses of texture and magnetic properties indicate that such unexpected orientations are caused by a predominance of single magnetic domains of magnetite and/or the existence of ankerite and siderite veins in which the long axes of crystals are oriented perpendicular to the foliation in the mélange. As a consequence, the restored shear direction deduced from AMS data improved the credibility of the kinematics of ancient plate motions. Although AMS data provide useful information on shear directions in mélanges, it is essential to examine the magnetic carriers and their magnetic domain structures for accuracy of the analyses.

  13. Modelling the impact of submarine frontal melting and ice mélange on glacier dynamics

    NASA Astrophysics Data System (ADS)

    Krug, J.; Durand, G.; Gagliardini, O.; Weiss, J.

    2015-01-01

    Two mechanisms are generally proposed to explain seasonal variations in the calving front of tidewater glaciers: submarine melting of the calving face and the mechanical back-force applied by the ice mélange. However, the way these processes affect the calving rate and the glacier dynamics remains uncertain. In this study, we used the finite element model Elmer/Ice to simulate the impact of these forcings on more than 200 two dimensional theoretical flowline glacier configurations. The model, which includes calving processes, suggests that frontal melting affects the position of the terminus only slightly (< a few hundred meters) and does not affect the pluriannual glacier mass balance at all. However, the ice mélange has a greater impact on the advance and retreat cycles of the glacier front (more than several 1000 m) and its consequences for the mass balance are not completely negligible, stressing the need for better characterization of forcing properties. We also show that ice mélange forcing against the calving face can mechanically prevent crevasse propagation at sea level and hence prevent calving. Results also revealed different behaviors in grounded and floating glaciers: in the case of a floating extension, the heaviest forcings can disrupt the glacier equilibrium by modifying its buttressing and ice flux at the grounding line.

  14. Cornelia de Lange syndrome with optic disk pit: Novel association and review of literature.

    PubMed

    Shenoy, Bhamy Hariprasad; Gupta, Amit; Sachdeva, Virender; Kekunnaya, Ramesh

    2014-05-01

    Cornelia de Lange syndrome (CdLS), also called Brachmann-de Lange syndrome, is a multiple congenital anomaly syndrome characterized by a distinctive facial appearance, ophthalmological abnormalities, prenatal and postnatal growth deficiency, psychomotor delay, behavioral problems, and malformations of the upper extremities. Most common and consistent ophthalmic features reported are nasolacrimal duct obstruction, long and curly eyelashes, blepharitis, ptosis, synophrys, telecanthus, hypertelorism, microcornea, peripapillary pigment ring, and myopia. In this report we report a case of a 5-year old boy who presented to our institution with complaint of blurring of vision in the right eye since birth. A diagnosis of Cornelia de Lange syndrome was arrived at based on the characteristic external and ophthalmic examination. He was found to have a rare association of optic nerve head coloboma in the right eye and a novel finding of an optic disk pit in the left eye. The association of optic disk pit with CdLS has never been reported earlier. We aim to provide a thorough review of literature of this not so uncommon syndrome.

  15. Behavioral Phenotype and Autism Spectrum Disorders in Cornelia de Lange Syndrome

    PubMed Central

    Parisi, Lucia; Di Filippo, Teresa; Roccella, Michele

    2015-01-01

    Cornelia de Lange syndrome (CdLS) is a congenital disorder characterized by distinctive facial features, growth retardation, limb abnormalities, intellectual disability, and behavioral problems. Cornelia de Lange syndrome is associated with abnormalities on chromosomes 5, 10 and X. Heterozygous point mutations in three genes (NIPBL, SMC3 and SMC1A), are responsible for approximately 50-60% of CdLS cases. CdLS is characterized by autistic features, notably excessive repetitive behaviors and expressive language deficits. The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in CdLS. However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. A significantly higher prevalence of self-injury are evident in CdLS. Self-injury was associated with repetitive and impulsive behavior. This study describes the behavioral phenotype of four children with Cornelia de Lange syndrome and ASDs and rehabilitative intervention that must be implemented. PMID:26605036

  16. A series of 38 novel germline and somatic mutations of NIPBL in Cornelia de Lange syndrome.

    PubMed

    Nizon, M; Henry, M; Michot, C; Baumann, C; Bazin, A; Bessières, B; Blesson, S; Cordier-Alex, M-P; David, A; Delahaye-Duriez, A; Delezoïde, A-L; Dieux-Coeslier, A; Doco-Fenzy, M; Faivre, L; Goldenberg, A; Layet, V; Loget, P; Marlin, S; Martinovic, J; Odent, S; Pasquier, L; Plessis, G; Prieur, F; Putoux, A; Rio, M; Testard, H; Bonnefont, J-P; Cormier-Daire, V

    2016-05-01

    Cornelia de Lange syndrome is a multisystemic developmental disorder mainly related to de novo heterozygous NIPBL mutation. Recently, NIPBL somatic mosaicism has been highlighted through buccal cell DNA study in some patients with a negative molecular analysis on leukocyte DNA. Here, we present a series of 38 patients with a Cornelia de Lange syndrome related to a heterozygous NIPBL mutation identified by Sanger sequencing. The diagnosis was based on the following criteria: (i) intrauterine growth retardation and postnatal short stature, (ii) feeding difficulties and/or gastro-oesophageal reflux, (iii) microcephaly, (iv) intellectual disability, and (v) characteristic facial features. We identified 37 novel NIPBL mutations including 34 in leukocytes and 3 in buccal cells only. All mutations shown to have arisen de novo when parent blood samples were available. The present series confirms the difficulty in predicting the phenotype according to the NIPBL mutation. Until now, somatic mosaicism has been observed for 20 cases which do not seem to be consistently associated with a milder phenotype. Besides, several reports support a postzygotic event for those cases. Considering these elements, we recommend a first-line buccal cell DNA analysis in order to improve gene testing sensitivity in Cornelia de Lange syndrome and genetic counselling. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Progress in cellular analysis using ToF-SIMS

    NASA Astrophysics Data System (ADS)

    Lockyer, N. P.; Vickerman, J. C.

    2004-06-01

    The analysis of cellular biochemistry represents an exciting frontier for ToF-SIMS. The rewards of opening up the life sciences arena are extremely high and a number of groups are demonstrating significant progress towards this goal. However, there are many challenges to be overcome, including sample preparation, sensitivity of detection and data interpretation. In this paper we review some strategies for meeting these challenges. We report the preparation of microbial and mammalian cells using rapid freezing and freeze-fracture to preserve cellular chemistry in a 'life-like' state. ToF-SIMS images of both frozen-hydrated and freeze-dried samples reveal molecular information from single cells, including components of the cell wall, membrane and cytoplasm. The use of Au + primary ions provides increased yields of molecular ions from cellular samples, compared to Ga + bombardment. Polyatomic primary ions such as Au n+ and C 60+ provide even higher yields, extending the mass range of detected biomolecules. The application of principal component analysis aids interpretation of the complex ToF-SIMS spectra from cellular samples. This ToF-SIMS/PCA approach allows the classification of yeast cells from different species and strains, and non-malignant and malignant cancer cells derived from different metastatic sites.

  18. Method for macromolecular colocalization using atomic recombination in dynamic SIMS.

    PubMed

    Legent, G; Delaune, A; Norris, V; Delcorte, A; Gibouin, D; Lefebvre, F; Misevic, G; Thellier, M; Ripoll, C

    2008-05-01

    Localizing two or more components of assemblies in biological systems requires both continued development of fluorescence techniques and invention of entirely new techniques. Candidates for the latter include dynamic secondary ion mass spectrometry (D-SIMS). The latest generation of D-SIMS, the Cameca NanoSIMS 50, permits the localization of specific, isotopically labeled molecules and macromolecules in sections of biological material with a resolution in the tens of nanometers and with a sensitivity approaching in principle that of a single protein. Here we use two different systems, crystals of glycine and mixtures of proteins, to show that the formation of recombinant CN secondary ions under Cs bombardment can be exploited to create a new colocalization technique. We show experimentally that the formation of the recombinant (13)C(15)N secondary ion between (13)C- and (15)N-labeled macromolecules is indeed an indicator of the distance between the interacting macromolecules and on their shape. We build up a convolution model of the mixing-recombination process in D-SIMS that allows quantitative interpretations of the distance-dependent formation of the recombinant CN. Our results show that macromolecules can be colocalized if they are within 2 nm of one another. We discuss the potential advantages of this new technique for biological applications.

  19. Kite: Status of the External Metrology Testbed for SIM

    NASA Technical Reports Server (NTRS)

    Dekens, Frank G.; Alvarez-Salazar, Oscar; Azizi, Alireza; Moser, Steven; Nemati, Bijan; Negron, John; Neville, Timothy; Ryan, Daniel

    2004-01-01

    Kite is a system level testbed for the External Metrology system of the Space Interferometry Mission (SIM). The External Metrology System is used to track the fiducial that are located at the centers of the interferometer's siderostats. The relative changes in their positions needs to be tracked to tens of picometers in order to correct for thermal measurements, the Kite testbed was build to test both the metrology gauges and out ability to optically model the system at these levels. The Kite testbed is an over-constraint system where 6 lengths are measured, but only 5 are needed to determine the system. The agreement in the over-constrained length needs to be on the order of 140 pm for the SIM Wide-Angle observing scenario and 8 pm for the Narrow-Angle observing scenario. We demonstrate that we have met the Wide-Angle goal with our current setup. For the Narrow-Angle case, we have only reached the goal for on-axis observations. We describe the testbed improvements that have been made since our initial results, and outline the future Kite changes that will add further effects that SIM faces in order to make the testbed more SIM like.

  20. Ambient analysis of liquid materials with Wet-SIMS

    NASA Astrophysics Data System (ADS)

    Seki, Toshio; Kusakari, Masakazu; Fujii, Makiko; Aoki, Takaaki; Matsuo, Jiro

    2016-03-01

    Secondary ion mass spectrometry (SIMS) is a method with high surface sensitivity that allows both elemental and molecular analysis. However, volatile liquid (wet) samples are difficult to measure using conventional SIMS, because samples must be dried and introduced into a high vacuum chamber. The mean free path of ions with energy in the keV range is very short in low vacuum and these ions cannot penetrate the surface. In contrast, ions in the MeV-energy range have high transmission capability in low vacuum and wet samples can be measured using heavy ions without dry sample preparation. Ion beams in the MeV-energy range also excite electrons near the surface and enhance the ionization of high-mass molecules and thus fragment-suppressed SIMS spectra of ionized molecules can be obtained. We have developed an ambient analysis system with secondary ion mass spectrometry for wet samples (Wet-SIMS) that operates from low vacuum to 30 kPa using MeV-energy heavy ion beams. The system is equipped with fine apertures that avoid vacuum degradation at both the primary beam incidence and the secondary ion measurement sides, even when the target chamber is filled with He gas at 30 kPa. Water evaporation was suppressed in a He atmosphere of 16.5 kPa and a solution of benzoic acid could be measured using MeV-energy heavy ions.

  1. Sim4cc: a cross-species spliced alignment program.

    PubMed

    Zhou, Leming; Pertea, Mihaela; Delcher, Arthur L; Florea, Liliana

    2009-06-01

    Advances in sequencing technologies have accelerated the sequencing of new genomes, far outpacing the generation of gene and protein resources needed to annotate them. Direct comparison and alignment of existing cDNA sequences from a related species is an effective and readily available means to determine genes in the new genomes. Current spliced alignment programs are inadequate for comparing sequences between different species, owing to their low sensitivity and splice junction accuracy. A new spliced alignment tool, sim4cc, overcomes problems in the earlier tools by incorporating three new features: universal spaced seeds, to increase sensitivity and allow comparisons between species at various evolutionary distances, and powerful splice signal models and evolutionarily-aware alignment techniques, to improve the accuracy of gene models. When tested on vertebrate comparisons at diverse evolutionary distances, sim4cc had significantly higher sensitivity compared to existing alignment programs, more than 10% higher than the closest competitor for some comparisons, while being comparable in speed to its predecessor, sim4. Sim4cc can be used in one-to-one or one-to-many comparisons of genomic and cDNA sequences, and can also be effectively incorporated into a high-throughput annotation engine, as demonstrated by the mapping of 64,000 Fagus grandifolia 454 ESTs and unigenes to the poplar genome.

  2. Astrophysics Goals of the SIM PlanetQuest Mission

    NASA Astrophysics Data System (ADS)

    Unwin, S. C.

    2005-05-01

    The Space Interferometry Mission PlanetQuest (SIM PlanetQuest), will be NASA's first space-based instrument capable of microarcsecond astrometry, and it will attack a wide range of topics in extrasolar planet detection, stellar, and galactic astrophysics. Precision astrometry is one of the cornerstones of modern astrophysics. This paper serves as an introduction to a series of papers highlighting some of the science SIM PlanetQuest will be capable of. The project is currently in project Phase B, with a projected launch in 2010. SIM PlanetQuest astrometry at a level approaching 1 microarcsecond over a narrow field will enable searches for planets with close to terrestrial masses. It will fully characterize the multiple-planet systems already known to exist, and will search for planets around young stars, to help us understand their formation and evolution. At a global astrometric accuracy of around 4 microarcseconds, it will deliver very accurate distances to many interesting stellar types, including exotic systems such as black hole binaries. Precision proper motions will allow SIM PlanetQuest to probe the galactic mass distribution, and through studies of tidal tails, the formation and evolution of the galactic halo. This work was performed at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

  3. Kite: Status of the External Metrology Testbed for SIM

    NASA Technical Reports Server (NTRS)

    Dekens, Frank G.; Alvarez-Salazar, Oscar; Azizi, Alireza; Moser, Steven; Nemati, Bijan; Negron, John; Neville, Timothy; Ryan, Daniel

    2004-01-01

    Kite is a system level testbed for the External Metrology system of the Space Interferometry Mission (SIM). The External Metrology System is used to track the fiducial that are located at the centers of the interferometer's siderostats. The relative changes in their positions needs to be tracked to tens of picometers in order to correct for thermal measurements, the Kite testbed was build to test both the metrology gauges and out ability to optically model the system at these levels. The Kite testbed is an over-constraint system where 6 lengths are measured, but only 5 are needed to determine the system. The agreement in the over-constrained length needs to be on the order of 140 pm for the SIM Wide-Angle observing scenario and 8 pm for the Narrow-Angle observing scenario. We demonstrate that we have met the Wide-Angle goal with our current setup. For the Narrow-Angle case, we have only reached the goal for on-axis observations. We describe the testbed improvements that have been made since our initial results, and outline the future Kite changes that will add further effects that SIM faces in order to make the testbed more SIM like.

  4. ToF-SIMS PCA analysis of Myrtus communis L.

    NASA Astrophysics Data System (ADS)

    Piras, F. M.; Dettori, M. F.; Magnani, A.

    2009-06-01

    Nowadays there is a growing interest of researchers for the application of sophisticated analytical techniques in conjunction with statistical data analysis methods to the characterization of natural products to assure their authenticity and quality, and for the possibility of direct analysis of food to obtain maximum information. In this work, time-of-flight secondary ion mass spectrometry (ToF-SIMS) in conjunction with principal components analysis (PCA) are applied to study the chemical composition and variability of Sardinian myrtle ( Myrtus communis L.) through the analysis of both berries alcoholic extracts and berries epicarp. ToF-SIMS spectra of berries epicarp show that the epicuticular waxes consist mainly of carboxylic acids with chain length ranging from C20 to C30, or identical species formed from fragmentation of long-chain esters. PCA of ToF-SIMS data from myrtle berries epicarp distinguishes two groups characterized by a different surface concentration of triacontanoic acid. Variability in antocyanins, flavonols, α-tocopherol, and myrtucommulone contents is showed by ToF-SIMS PCA analysis of myrtle berries alcoholic extracts.

  5. O-Isotope Features of Chondrules from Recent SIMS Studies

    NASA Astrophysics Data System (ADS)

    Tenner, T. J.; Ushikubo, T.; Nakashima, D.; Schrader, D. L.; Weisberg, M. K.; Kimura, M.; Kita, N. T.

    2017-02-01

    We highlight results of recent chondrule O-isotope studies by SIMS: (1) primary and secondary features based on the level of isotope homogeneity, (2) comparing ranges of host and relict data among chondrites, (3) O-isotope vs. major element links.

  6. SIMS prototype system 3 test results: Engineering analysis

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The results obtained during testing of a closed hydronic drain down solar system designed for space and hot water heating is presented. Data analysis is included which documents the system performance and verifies the suitability of SIMS Prototype System 3 for field installation.

  7. SimSum: An Empirically Founded Simulation of Summarizing.

    ERIC Educational Resources Information Center

    Endres-Niggemeyer, Brigitte

    2000-01-01

    Describes SimSum (Simulation of Summarizing), which simulates 20 real-world working steps of expert summarizers. Presents an empirically founded cognitive model of summarizing and demonstrates that human summarization strategies can be simulated. Discusses current research in automatic summarization, summarizing in the World Wide Web, and…

  8. Development practices and lessons learned in developing SimPEG

    NASA Astrophysics Data System (ADS)

    Cockett, R.; Heagy, L. J.; Kang, S.; Rosenkjaer, G. K.

    2015-12-01

    Inverse modelling provides a mathematical framework for constructing a model of physical property distributions in the subsurface that are consistent with the data collected in geophysical surveys. The geosciences are increasingly moving towards the integration of geological, geophysical, and hydrological information to better characterize the subsurface. This integration must span disciplines and is not only challenging scientifically, but additionally the inconsistencies between conventions often makes implementations complicated, non­ reproducible, or inefficient. SimPEG is an open-source, multi-university effort aimed at providing a generalized framework for solving forward and inverse problems. SimPEG includes finite volume discretizations on structured and unstructured meshes, interfaces to standard numerical solver packages, convex optimization algorithms, model parameterizations, and visualization routines. The SimPEG package (http://simpeg.xyz) supports an ecosystem of forward and inverse modelling applications, including electromagnetics, vadose zone flow, seismic, and potential­ fields, that are all written with a common interface and toolbox. The goal of SimPEG is to support a community of researchers with well-tested, extensible tools, and encourage transparency and reproducibility both of the SimPEG software and the geoscientific research it is applied to. In this presentation, we will share some of the lessons we have learned in designing the modular infrastructure, testing and development practices of SimPEG. We will discuss our use of version control, extensive unit-testing, continuous integration, documentation, issue tracking, and resources that facilitate communication between existing team members and allows new researchers to get involved. These practices have enabled the use of SimPEG in research, industry, and education as well as the ability to support a growing number of dependent repositories and applications. We hope that sharing our

  9. Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.

    PubMed

    Kersseboom, Simone; Kremers, Gert-Jan; Friesema, Edith C H; Visser, W Edward; Klootwijk, Wim; Peeters, Robin P; Visser, Theo J

    2013-05-01

    Monocarboxylate transporter 8 (MCT8) is a thyroid hormone (TH)-specific transporter. Mutations in the MCT8 gene are associated with Allan-Herndon-Dudley Syndrome (AHDS), consisting of severe psychomotor retardation and disturbed TH parameters. To study the functional consequences of different MCT8 mutations in detail, we combined functional analysis in different cell types with live-cell imaging of the cellular distribution of seven mutations that we identified in patients with AHDS. We used two cell models to study the mutations in vitro: 1) transiently transfected COS1 and JEG3 cells, and 2) stably transfected Flp-in 293 cells expressing a MCT8-cyan fluorescent protein construct. All seven mutants were expressed at the protein level and showed a defect in T3 and T4 transport in uptake and metabolism studies. Three mutants (G282C, P537L, and G558D) had residual uptake activity in Flp-in 293 and COS1 cells, but not in JEG3 cells. Four mutants (G221R, P321L, D453V, P537L) were expressed at the plasma membrane. The mobility in the plasma membrane of P537L was similar to WT, but the mobility of P321L was altered. The other mutants studied (insV236, G282C, G558D) were predominantly localized in the endoplasmic reticulum. In essence, loss of function by MCT8 mutations can be divided in two groups: mutations that result in partial or complete loss of transport activity (G221R, P321L, D453V, P537L) and mutations that mainly disturb protein expression and trafficking (insV236, G282C, G558D). The cell type-dependent results suggest that MCT8 mutations in AHDS patients may have tissue-specific effects on TH transport probably caused by tissue-specific expression of yet unknown MCT8-interacting proteins.

  10. Carbonates in fractures of Martian meteorite Allan Hills 84001: petrologic evidence for impact origin

    NASA Technical Reports Server (NTRS)

    Scott, E. R.; Krot, A. N.; Yamaguchi, A.

    1998-01-01

    Carbonates in Martian meteorite Allan Hills 84001 occur as grains on pyroxene grain boundaries, in crushed zones, and as disks, veins, and irregularly shaped grains in healed pyroxene fractures. Some carbonate disks have tapered Mg-rich edges and are accompanied by smaller, thinner and relatively homogeneous, magnesite microdisks. Except for the microdisks, all types of carbonate grains show the same unique chemical zoning pattern on MgCO3-FeCO3-CaCO3 plots. This chemical characteristic and the close spatial association of diverse carbonate types show that all carbonates formed by a similar process. The heterogeneous distribution of carbonates in fractures, tapered shapes of some disks, and the localized occurrence of Mg-rich microdisks appear to be incompatible with growth from an externally derived CO2-rich fluid that changed in composition over time. These features suggest instead that the fractures were closed as carbonates grew from an internally derived fluid and that the microdisks formed from a residual Mg-rich fluid that was squeezed along fractures. Carbonate in pyroxene fractures is most abundant near grains of plagioclase glass that are located on pyroxene grain boundaries and commonly contain major or minor amounts of carbonate. We infer that carbonates in fractures formed from grain boundary carbonates associated with plagiociase that were melted by impact and dispersed into the surrounding fractured pyroxene. Carbonates in fractures, which include those studied by McKay et al. (1996), could not have formed at low temperatures and preserved mineralogical evidence for Martian organisms.

  11. Carbonates in fractures of Martian meteorite Allan Hills 84001: petrologic evidence for impact origin

    NASA Technical Reports Server (NTRS)

    Scott, E. R.; Krot, A. N.; Yamaguchi, A.

    1998-01-01

    Carbonates in Martian meteorite Allan Hills 84001 occur as grains on pyroxene grain boundaries, in crushed zones, and as disks, veins, and irregularly shaped grains in healed pyroxene fractures. Some carbonate disks have tapered Mg-rich edges and are accompanied by smaller, thinner and relatively homogeneous, magnesite microdisks. Except for the microdisks, all types of carbonate grains show the same unique chemical zoning pattern on MgCO3-FeCO3-CaCO3 plots. This chemical characteristic and the close spatial association of diverse carbonate types show that all carbonates formed by a similar process. The heterogeneous distribution of carbonates in fractures, tapered shapes of some disks, and the localized occurrence of Mg-rich microdisks appear to be incompatible with growth from an externally derived CO2-rich fluid that changed in composition over time. These features suggest instead that the fractures were closed as carbonates grew from an internally derived fluid and that the microdisks formed from a residual Mg-rich fluid that was squeezed along fractures. Carbonate in pyroxene fractures is most abundant near grains of plagioclase glass that are located on pyroxene grain boundaries and commonly contain major or minor amounts of carbonate. We infer that carbonates in fractures formed from grain boundary carbonates associated with plagiociase that were melted by impact and dispersed into the surrounding fractured pyroxene. Carbonates in fractures, which include those studied by McKay et al. (1996), could not have formed at low temperatures and preserved mineralogical evidence for Martian organisms.

  12. COORDINATED ANALYSES OF PRESOLAR GRAINS IN THE ALLAN HILLS 77307 AND QUEEN ELIZABETH RANGE 99177 METEORITES

    SciTech Connect

    Nguyen, Ann N.; Nittler, Larry R.; Alexander, Conel M. O'D.; Stadermann, Frank J.; Stroud, Rhonda M.

    2010-08-10

    We report the identification of presolar silicates ({approx}177 ppm), presolar oxides ({approx}11 ppm), and one presolar SiO{sub 2} grain in the Allan Hills (ALHA) 77307 chondrite. Three grains having Si-isotopic compositions similar to SiC X and Z grains were also identified, though the mineral phases are unconfirmed. Similar abundances of presolar silicates ({approx}152 ppm) and oxides ({approx}8 ppm) were also uncovered in the primitive CR chondrite Queen Elizabeth Range (QUE) 99177, along with 13 presolar SiC grains and one presolar silicon nitride. The O-isotopic compositions of the presolar silicates and oxides indicate that most of the grains condensed in low-mass red giant and asymptotic giant branch stars. Interestingly, unlike presolar oxides, few presolar silicate grains have isotopic compositions pointing to low-metallicity, low-mass stars (Group 3). The {sup 18}O-rich (Group 4) silicates, along with the few Group 3 silicates that were identified, likely have origins in supernova outflows. This is supported by their O- and Si-isotopic compositions. Elemental compositions for 74 presolar silicate grains were determined by scanning Auger spectroscopy. Most of the grains have non-stoichiometric elemental compositions inconsistent with pyroxene or olivine, the phases commonly used to fit astronomical spectra, and have comparable Mg and Fe contents. Non-equilibrium condensation and/or secondary alteration could produce the high Fe contents. Transmission electron microscopic analysis of three silicate grains also reveals non-stoichiometric compositions, attributable to non-equilibrium or multistep condensation, and very fine scale elemental heterogeneity, possibly due to subsequent annealing. The mineralogies of presolar silicates identified in meteorites thus far seem to differ from those in interplanetary dust particles.

  13. Using Allan variance to evaluate the relative accuracy on different time scales of GNSS/INS systems

    NASA Astrophysics Data System (ADS)

    Zhang, Quan; Niu, Xiaoji; Chen, Qijin; Zhang, Hongping; Shi, Chuang

    2013-08-01

    The integration of the Global Navigation Satellite System (GNSS) with an inertial navigation system (INS) can provide accurate and reliable navigation information using a data fusing algorithm such as a Kalman filter. There has been much interest in the absolute accuracy with dominant components of mid-term and long-term errors in current research works related to the GNSS/INS navigation systems, whereas few research works focus on the relative accuracy on different time scales. However, new applications of GNSS/INS integration, such as position and orientation system for mobile mapping systems and the GNSS/INS deeply-coupled receiver, require the relative accuracy on different time scales, especially that of the short-term accuracy. This paper raises the importance of the short-term accuracy of the GNSS/INS systems in certain applications. Current methods to evaluate the navigation accuracy are mainly to provide some statistical values that can represent the overall error level (e.g., RMS), but cannot show the relative accuracy. Allan variance is a method of representing root mean square (RMS) random drift error as a function of average time. An Allan variance analysis method is proposed in this paper to evaluate the relative accuracy on different time scales of GNSS/INS systems. The feasibility of the idea was verified by the road test results of different grades of GNSS/INS systems. The results show that Allan variance can give the levels of the navigation accuracy of the GNSS/INS systems on different time scales in an effective way, especially for the short-term accuracy.

  14. Results from SIM's Thermo-Opto-Mechanical (TOM3) Testbed

    NASA Technical Reports Server (NTRS)

    Goullioud, Renaud; Lindensmith, C. A.; Hahn, I.

    2006-01-01

    Future space-based optical interferometers, such as the Space Interferometer Mission Planet Quest (SIM), require thermal stability of the optical wavefront to the level of picometers in order to produce astrometric data at the micro-arc-second level. In SIM, the internal path of the interferometer will be measured with a small metrology beam whereas the starlight fringe position is estimated from a large concentric annular beam. To achieve the micro-arc-second observation goal for SIM, it is necessary to maintain the optical path difference between the central and the outer annulus portions of the wavefront of the front-end telescope optics to a few tens of picometers. The Thermo-Opto-Mecha nical testbed (TOM3) was developed at the Jet Propulsion Laboratory to measure thermally induced optical deformations of a full-size flight-like beam compressor and siderostat, the two largest optics on SIM, in flight-like thermal environments. A Common Path Heterodyne Interferometer (COPHI) developed at JPL was used for the fine optical path difference measurement as the metrology sensor. The system was integrated inside a large vacuum chamber in order to mitigate the atmospheric and thermal disturbances. The siderostat was installed in a temperature-controlled thermal shroud inside the vacuum chamber, creating a flight-like thermal environment. Detailed thermal and structural models of the test articles (siderostat and compressor) were also developed for model prediction and correlation of the thermal deformations. Experimental data shows SIM required thermal stability of the test articles and good agreement with the model predictions.

  15. High-resolution SIMS depth profiling of nanolayers.

    SciTech Connect

    Baryshev, S. V.; Zinovev, A. V.; Tripa, C. E.; Pellin, M. J.; Peng, Q.; Elam, J. W.; Veryovkin, I. V.

    2012-10-15

    Although the fundamental physical limits for depth resolution of secondary ion mass spectrometry are well understood in theory, the experimental work to achieve and demonstrate them is still ongoing. We report results of high-resolution TOF SIMS (time-of-flight secondary ion mass spectrometry) depth profiling experiments on a nanolayered structure, a stack of 16 alternating MgO and ZnO {approx}5.5 nm layers grown on a Si substrate by atomic layer deposition. The measurements were performed using a newly developed approach implementing a low-energy direct current normally incident Ar{sup +} ion beam for ion milling (250 eV and 500 eV energy), in combination with a pulsed 5 keV Ar{sup +} ion beam at 60{sup o} incidence for TOF SIMS analysis. By this optimized arrangement, a noticeably improved version of the dual-beam (DB) approach to TOF SIMS depth profiling is introduced, which can be dubbed gentleDB. The mixing-roughness-information model was applied to detailed analysis of experimental results. It revealed that the gentleDB approach allows ultimate depth resolution by confining the ion beam mixing length to about two monolayers. This corresponds to the escape depth of secondary ions, the fundamental depth resolution limitation in SIMS. Other parameters deduced from the measured depth profiles indicated that a single layer thickness is equal to 6 nm so that the 'flat' layer thickness d is 3 nm and the interfacial roughness {sigma} is 1.5 nm, thus yielding d + 2{sigma} = 6 nm. We have demonstrated that gentleDB TOF SIMS depth profiling with noble gas ion beams is capable of revealing the structural features of a stack of nanolayers, resolving its original surface and estimating the roughness of interlayer interfaces, information which is difficult to obtain by traditional approaches.

  16. AlphaSim: Software for Breeding Program Simulation.

    PubMed

    Faux, Anne-Michelle; Gorjanc, Gregor; Gaynor, R Chris; Battagin, Mara; Edwards, Stefan M; Wilson, David L; Hearne, Sarah J; Gonen, Serap; Hickey, John M

    2016-11-01

    This paper describes AlphaSim, a software package for simulating plant and animal breeding programs. AlphaSim enables the simulation of multiple aspects of breeding programs with a high degree of flexibility. AlphaSim simulates breeding programs in a series of steps: (i) simulate haplotype sequences and pedigree; (ii) drop haplotypes into the base generation of the pedigree and select single-nucleotide polymorphism (SNP) and quantitative trait nucleotide (QTN); (iii) assign QTN effects, calculate genetic values, and simulate phenotypes; (iv) drop haplotypes into the burn-in generations; and (v) perform selection and simulate new generations. The program is flexible in terms of historical population structure and diversity, recent pedigree structure, trait architecture, and selection strategy. It integrates biotechnologies such as doubled-haploids (DHs) and gene editing and allows the user to simulate multiple traits and multiple environments, specify recombination hot spots and cold spots, specify gene jungles and deserts, perform genomic predictions, and apply optimal contribution selection. AlphaSim also includes restart functionalities, which increase its flexibility by allowing the simulation process to be paused so that the parameters can be changed or to import an externally created pedigree, trial design, or results of an analysis of previously simulated data. By combining the options, a user can simulate simple or complex breeding programs with several generations, variable population structures and variable breeding decisions over time. In conclusion, AlphaSim is a flexible and computationally efficient software package to simulate biotechnology enhanced breeding programs with the aim of performing rapid, low-cost, and objective in silico comparison of breeding technologies. Copyright © 2016 Crop Science Society of America.

  17. Bulk and Stable Isotopic Compositions of Carbonate Minerals in Martian Meteorite Allan Hills 84001: No Proof of High Formation Temperature

    NASA Technical Reports Server (NTRS)

    Treiman, Allan H.; Romanek, Christopher S.

    1998-01-01

    Understanding the origin of carbonate minerals in the Martian meteorite Allan Hills (ALH) 84001 is crucial to evaluating the hypothesis that they contain traces of ancient Martian life. Using arguments based on chemical equilibria among carbonates and fluids, an origin at greater than 650 C (inimical to life) has been proposed. However, the bulk and stable isotopic compositions of the carbonate minerals are open to multiple interpretations and so lend no particular support to a high-temperature origin. Other methods (possibly less direct) will have to be used to determine the formation temperature of the carbonates in ALH 84001.

  18. The periodogram and Allan variance reveal fractal exponents greater than unity in auditory-nerve spike trains.

    PubMed

    Lowen, S B; Teich, M C

    1996-06-01

    Auditory-nerve spike trains exhibit fractal behavior, and therefore traditional renewal-point-process models fail to describe them adequately. Previous measures of the fractal exponent of these spike trains are based on the Fano factor and consequently cannot exceed unity. Two estimates of the fractal exponent are considered which do not suffer from this limit: one derived from the Allan variance, which was developed by the authors, and one based on the periodogram. These measures indicate that fractal exponents do indeed exceed unity for some nerve-spike recordings from stimulated primary afferent cat auditory-nerve fibers.

  19. Lawsonite Blueschists in Recycled Mélange Involved in K-Rich Orogenic Magmatism

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Prelevic, D.; Foley, S. F.; Buhre, S.; Galer, S. J. G.

    2014-12-01

    The origin of K-rich orogenic magmatism in the Alpine-Himalayan belt and its relationship to the large-scale elevations in several massifs of the orogen is controversial, particularly the significance of the widespread presence of a geochemical signal typical for recycled continental crust. Two competing scenarios invoke direct melting of continental crust during deep intercontinental subduction and removal of heavily metasomatised mantle lithosphere by delamination into the convecting mantle. Here we investigate the coupling of high Th/La ratio with crustal isotopic signatures in K-rich orogenic lavas that does not occur in volcanic rocks from other collisional environments to distinguish between these two models. High-pressure experimental results on a phyllite representing upper crustal composition and a detailed mineral and geochemical study of blueschists from Tavşanlı mélange, Turkey, indicate that this geochemical fingerprint originates by melting of subducted mélange. Melting of crust at the top of the subducted continental lithosphere cannot produce observed fingerprint, whereas lawsonites, especially those with terrigenous sediment origin from blueschists with high Th/La can. Lawsonites that grow in various components of a subduction mélange inherit the geochemical characteristics of either oceanic or continental protoliths. It is currently uncertain whether those carrying the high Th/La signature originate by direct melting of continental blocks in the mélange or by the introduction of supercritical fluids from lawsonite blueschist of continental origin that infiltrate oceanic sediment blocks. Either way, the high Th/La is later released into subsequently formed melts. This confirms the supposition that lawsonite is the main progenitor of the high Th/La and Sm/La ratio. However, lawsonite must break down completely to impart this unique feature to subsequent magmas. The source regions of the potassic volcanic rocks consist of blueschist facies mélanges

  20. Teaching the Teacher: Tutoring SimStudent Leads to More Effective Cognitive Tutor Authoring

    ERIC Educational Resources Information Center

    Matsuda, Noboru; Cohen, William W.; Koedinger, Kenneth R.

    2015-01-01

    SimStudent is a machine-learning agent initially developed to help novice authors to create cognitive tutors without heavy programming. Integrated into an existing suite of software tools called Cognitive Tutor Authoring Tools (CTAT), SimStudent helps authors to create an expert model for a cognitive tutor by tutoring SimStudent on how to solve…

  1. Teaching the Teacher: Tutoring SimStudent Leads to More Effective Cognitive Tutor Authoring

    ERIC Educational Resources Information Center

    Matsuda, Noboru; Cohen, William W.; Koedinger, Kenneth R.

    2015-01-01

    SimStudent is a machine-learning agent initially developed to help novice authors to create cognitive tutors without heavy programming. Integrated into an existing suite of software tools called Cognitive Tutor Authoring Tools (CTAT), SimStudent helps authors to create an expert model for a cognitive tutor by tutoring SimStudent on how to solve…

  2. Sedimentary Origins Of The Block-In-Matrix Fabric Of A Mélange Between Coherent Nappes Of A Subduction Complex: Localization Of The Paleosubduction Megathrust Along The Upper Mélange Contact

    NASA Astrophysics Data System (ADS)

    Wakabayashi, J.

    2011-12-01

    The Franciscan subduction complex of California comprises coherent nappes and intervening mélanges. The difference in metamorphic grade and/or accretionary age of adjacent coherent nappes suggests localization of paleosubduction megathrust horizons between them. One of the best examples of a mélange between coherent nappes crops out in an inactive quarry in El Cerrito in the eastern San Francisco Bay area. The upper coherent nappe consists of foliated, jadeite-bearing, blueschist facies metagraywacke, whereas the lower coherent nappe comprises prehnite-pumpellyite facies graywacke with little or no penetrative fabric makes. Detrital zircon geochronology indicates maximum depositional ages of 102 and 100 Ma, respectively, for these units. The foliation or bedding of the graywackes and their contacts strike northwest and dip northeast. C-s fabrics, shear bands, and asymmetric porphyroclasts show a consistent tops-to-the-southwest shear sense in the upper coherent unit, and this fabric developed with syntectonic growth of glaucophane, lawsonite, and jadeite. The intervening mélange has a matrix made up primarily of dark gray shale, with blocks of mostly graywacke, chert, and basalt. The mélange consists of mostly or entirely prehnite-pumpellyite facies material except for the upper 5-10 meters that features metamorphic growth of lawsonite, glaucophane, and jadeite. Thus, the metamorphic contrast between the two nappes, equivalent to at least 10 km in differential burial depth and greater amount of fault displacement, occurs within this narrow zone. The upper half of the mélange (~50 meters of structural thickness) exhibits a pronounced foliation oriented parallel to the bounding contacts. The foliation deflects into shear bands and c-surfaces and this fabric shows a consistent tops-to-the-southwest shear sense. Strain appears to increase structurally upward within the mélange. The structurally lowest part of the mélange displays virtually no strain, with

  3. The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence

    PubMed Central

    Woods, Susan; Farrall, Alexandra; Procko, Carl; Whitelaw, Murray L.

    2008-01-01

    Despite a growing number of descriptive studies that show Single-minded 2 (Sim2) is not only essential for murine survival, but also upregulated in colon, prostate and pancreatic tumours, there is a lack of direct target genes identified for this basic helix–loop–helix/PAS transcription factor. We have performed a set of microarray experiments aimed at identifying genes that are differentially regulated by SIM2, and successfully verified that the Myomesin2 (Myom2) gene is SIM2-responsive. Although SIM2 has been reported to be a transcription repressor, we find that SIM2 induces transcription of Myom2 and activates the Myom2 promoter sequence when co-expressed with the heterodimeric partner protein, ARNT1, in human embryonic kidney cells. Truncation and mutation of the Myom2 promoter sequence, combined with chromatin immunoprecipitation studies in cells, has lead to the delineation of a non-canonical E-box sequence 5′-AACGTG-3′ that is bound by SIM2/ARNT1 heterodimers. Interestingly, in immortalized human myoblasts knock down of Sim2 results in increased levels of Myom2 RNA, suggesting that SIM2 is acting as a repressor in these cells and so its activity is likely to be highly context dependent. This is the first report of a direct SIM2/ARNT1 target gene with accompanying analysis of a functional response element. PMID:18480125

  4. Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.

    PubMed

    Xi, Dong; Roizen, Jeff; Lai, Meizan; Gandhi, Nilay; Kublaoui, Bassil

    2013-01-01

    Single minded 1 (SIM1) is a transcription factor involved in brain patterning and control of energy balance. In humans, haploinsufficiency of SIM1 causes early-onset obesity. Mice deficient in the homologous gene, SIM1, also exhibit early onset obesity and increased sensitivity to a high fat diet. SIM1 is expressed in several areas of the brain implicated in control of energy balance including the paraventricular nucleus (PVN), the supraoptic nucleus (SON), the medial amygdala and nucleus of the lateral olfactory tract. We have previously shown that mice with global Sim1 neuron ablation exhibit obesity with hyperphagia as the primary defect. The PVN has a critical role in feeding and in high-fat appetite, thus, we sought to determine the effect of Sim1 neuron ablation limited to the PVN. We achieved PVN-SIM1 limited ablation through stereotactic injection of diphtheria toxin into the PVN of Sim1Cre-iDTR mice. The specificity of this ablation was confirmed by immunohistochemistry and quantitative real time PCR of the PVN, supraoptic nucleus and the amygdala. Mice with PVN Sim1 neuron ablation, similar to mice with global Sim1 neuron ablation, exhibit early onset obesity with hyperphagia as the primary defect. However, PVN-Sim1 neuron ablated mice have a decreased response to fasting-induced hyperphagia. Consistent with this decrement, PVN-Sim1 neuron ablated mice have a decreased hyperphagic response to PVN injection of agouti-related peptide (AgRP). When PVN-Sim1 neuron ablated mice are placed on a high fat diet, surprisingly, their intake decreases and they actually lose weight. When allowed ad lib access to high fat diet and normal chow simultaneously, PVN-Sim1 neuron ablated mice exhibit overall decreased intake. That is, in PVN-Sim1 neuron ablated mice, access to fat suppresses overall appetite.

  5. Search for Terrestrial Planets with SIM Planet Quest

    NASA Technical Reports Server (NTRS)

    Shao, Michael; Tanner, Angelle M.; Catanzarite, Joseph H.

    2006-01-01

    SIM is an astrometric mission that will be capable of 1 microarcsec relative astrometric accuracy in a single measurement of approx.1000 sec. The search for terrestrial planets in the habitable zone around nearby stars is one of the main science goals of the project. In 2001, NASA through the peer review process selected 10 key projects, two of which had as its goal, the search for terrestrial planets around nearby stars. The two teams, one led by G. Marcy (UC Berkeley) and one lead by M. Shao (JPL), have an extensive preparatory science program underway. This paper describes the status of this activity as well as the technology status of SIM's narrow angle astrometry capability, to reach 1 uas in a single epoch measure and its ability to average multiple epoch measurements to well below 1 uas.

  6. Dynamic modeling of cellular populations within iBioSim.

    PubMed

    Stevens, Jason T; Myers, Chris J

    2013-05-17

    As the complexity of synthetic genetic circuits increases, modeling is becoming a necessary first step to inform subsequent experimental efforts. In recent years, the design automation community has developed a wealth of computational tools for assisting experimentalists in designing and analyzing new genetic circuits at several scales. However, existing software primarily caters to either the DNA- or single-cell level, with little support for the multicellular level. To address this need, the iBioSim software package has been enhanced to provide support for modeling, simulating, and visualizing dynamic cellular populations in a two-dimensional space. This capacity is fully integrated into the software, capitalizing on iBioSim's strengths in modeling, simulating, and analyzing single-celled systems.

  7. SIM Interferometer Testbed (SCDU) Status and Recent Results

    NASA Technical Reports Server (NTRS)

    Nemati, Bijan; An, Xin; Goullioud, Renaud; Shao, Michael; Shen, Tsae-Pyng; Wehmeier, Udo J.; Weilert, Mark A.; Wang, Xu; Werne, Thomas A.; Wu, Janet P.; Zhai, Chengxing

    2010-01-01

    SIM Lite is a space-borne stellar interferometer capable of searching for Earth-size planets in the habitable zones of nearby stars. This search will require measurement of astrometric angles with sub micro-arcsecond accuracy and optical pathlength differences to 1 picometer by the end of the five-year mission. One of the most significant technical risks in achieving this level of accuracy is from systematic errors that arise from spectral differences between candidate stars and nearby reference stars. The Spectral Calibration Development Unit (SCDU), in operation since 2007, has been used to explore this effect and demonstrate performance meeting SIM goals. In this paper we present the status of this testbed and recent results.

  8. Investigations of semiconductor devices using SIMS; diffusion, contamination, process control

    NASA Astrophysics Data System (ADS)

    Lee, Jae Cheol; Won, Jeongyeon; Chung, Youngsu; Lee, Hyungik; Lee, Eunha; Kang, Donghun; Kim, Changjung; Choi, Jinhak; Kim, Jeomsik

    2008-12-01

    We have surveyed 22,155 analyses issues to know the portion of surface analysis at the total analyses activities. According to the survey result, the contribution of SIMS in the total analyses issues was about 7%. The portions of semiconductor process control, composition and contamination in the SIMS analyses issues are 25%, 29% and 16%, respectively. In this article, some examples of the semiconductor device process control, identification of contaminants, and failure analyses have been reviewed. The behavior of H, O, and Ti at the Pt/Ti/GaInZnO interfaces and their influences on the electrical property of thin film transistor are demonstrated. Also discolor issues including organic material contamination problem on Au pad are discussed in detail.

  9. Search for Terrestrial Planets with SIM Planet Quest

    NASA Technical Reports Server (NTRS)

    Shao, Michael; Tanner, Angelle M.; Catanzarite, Joseph H.

    2006-01-01

    SIM is an astrometric mission that will be capable of 1 microarcsec relative astrometric accuracy in a single measurement of approx.1000 sec. The search for terrestrial planets in the habitable zone around nearby stars is one of the main science goals of the project. In 2001, NASA through the peer review process selected 10 key projects, two of which had as its goal, the search for terrestrial planets around nearby stars. The two teams, one led by G. Marcy (UC Berkeley) and one lead by M. Shao (JPL), have an extensive preparatory science program underway. This paper describes the status of this activity as well as the technology status of SIM's narrow angle astrometry capability, to reach 1 uas in a single epoch measure and its ability to average multiple epoch measurements to well below 1 uas.

  10. Using ToF-SIMS to study industrial surface phenomena

    NASA Astrophysics Data System (ADS)

    Smentkowski, Vincent S.; Keenan, Michael R.; Arlinghaus, Henrik

    2016-10-01

    Time of flight secondary ion mass spectrometry (ToF-SIMS) is frequently used to analyze industrial samples since it offers high (ppb) detection sensitivity, very high surface specificity (analysis of the top 1-3 surface layers during a spectral/image acquisition), high mass resolution (allowing the analyst the ability to separate Cu from C5H3 for instance), the ability to detect hydrogen, high depth resolution for depth profile measurements, and detection of high-mass fragments associated with molecular species/additives. In this manuscript, we demonstrate the advantages of ToF-SIMS including the ability to measure trace quantities of unexpected species on the surfaces of devices, and the ability to extract high-mass resolution information from data sets which were collected at degraded mass resolution. The importance of applying unbiased multivariate statistical analysis (MVSA) to the complete set of measured data is also demonstrated.

  11. BioFET-SIM web interface: implementation and two applications.

    PubMed

    Hediger, Martin R; Jensen, Jan H; De Vico, Luca

    2012-01-01

    We present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface.

  12. Exploration and development of the climate archive of the Allan Hills Blue Ice Area, Antarctica

    NASA Astrophysics Data System (ADS)

    Spaulding, Nicole E.

    The ice flow, stable water isotopic composition, and glaciochemistry of ice within the Allan Hills Blue Ice Area (AH BIA), Antarctica, is investigated to determine its potential for contributing to and extending the currently available 800 ka ice core record of paleoclimate. The investigation began with a study of ice dynamics within the AH BIA. The horizontal (u ) and vertical (z) ice velocities, determined using high-precision GPS measurements, are 1.5 to 50 (+0.12) cm a--1 and 2-3 (+/-0.50) cm a--1, respectively. The significant positive z and low u verify that old ice is present at the surface. Surface topography, in combination with u, was used to delineate a flowline (A-B) along which ice of continuous age was collected for the next stage of the investigation. Surface ice was recovered along 5 km of A-B and a 225 meter core was drilled at its midpoint. Ice samples were analyzed for stable isotopes of water (deltaD, delta 18O), which are common proxies for temperature. The resulting profiles exhibit variability consistent with the magnitude of glacial-interglacial transitions in East Antarctica. These variations, in combination with 40Aratm, and delta18O atm constrain the age of sampled ice to 90-250 ka. However, the 100 meters of directly above bedrock was not collected and the bottom depth is calculated to be at least 400 ka. The final phase of the investigation involved determining the concentrations of terrestrial and marine chemical species in ice from multiple points along A-B. Concentrations ranged from pg L--1 level for rare earth elements to microg L --1 level for multi-sourced compounds like sulfate. The concentrations of all analytes were anti-correlated with stable water isotope values indicating they had preserved a record of changes in atmospheric circulation, source strength, and continental aridity. The composition of rare earth elements points to Australia as an important interglacial dust source, while molar ratios of major ions, particularly

  13. SimGen: A General Simulation Method for Large Systems.

    PubMed

    Taylor, William R

    2017-02-03

    SimGen is a stand-alone computer program that reads a script of commands to represent complex macromolecules, including proteins and nucleic acids, in a structural hierarchy that can then be viewed using an integral graphical viewer or animated through a high-level application programming interface in C++. Structural levels in the hierarchy range from α-carbon or phosphate backbones through secondary structure to domains, molecules, and multimers with each level represented in an identical data structure that can be manipulated using the application programming interface. Unlike most coarse-grained simulation approaches, the higher-level objects represented in SimGen can be soft, allowing the lower-level objects that they contain to interact directly. The default motion simulated by SimGen is a Brownian-like diffusion that can be set to occur across all levels of representation in the hierarchy. Links can also be defined between objects, which, when combined with large high-level random movements, result in an effective search strategy for constraint satisfaction, including structure prediction from predicted pairwise distances. The implementation of SimGen makes use of the hierarchic data structure to avoid unnecessary calculation, especially for collision detection, allowing it to be simultaneously run and viewed on a laptop computer while simulating large systems of over 20,000 objects. It has been used previously to model complex molecular interactions including the motion of a myosin-V dimer "walking" on an actin fibre, RNA stem-loop packing, and the simulation of cell motion and aggregation. Several extensions to this original functionality are described.

  14. SIM PlanetQuest science and technology: a status report

    NASA Astrophysics Data System (ADS)

    Edberg, Stephen J.; Laskin, Robert A.; Marr, James C., IV; Unwin, Stephen C.; Shao, Michael

    2007-09-01

    Optical interferometry will open new vistas for astronomy over the next decade. The Space Interferometry Mission (SIM-PlanetQuest), operating unfettered by the Earth's atmosphere, will offer unprecedented astrometric precision that promises the discovery of Earth-analog extra-solar planets as well as a wealth of important astrophysics. Results from SIM will permit the determination of stellar masses to accuracies of 2% or better for objects ranging from brown dwarfs through main sequence stars to evolved white dwarfs, neutron stars, and black holes. Studies of star clusters will yield age determinations and internal dynamics. Microlensing measurements will present the mass spectrum of the Milky Way internal to the Sun while proper motion surveys will show the Sun's orbital radius and speed. Studies of the Galaxy's halo component and companion dwarf galaxies permit the determination of the Milky Way's mass distribution, including its Dark Matter component and the mass distribution and Dark Matter component of the Local Group. Cosmology benefits from precision (1-2%) determination of distances to Cepheid and RR Lyrae standard candles. The emission mechanism of supermassive black holes will be investigated. Finally, radio and optical celestial reference frames will be tied together by an improvement of two orders of magnitude. Optical interferometers present severe technological challenges. The Jet Propulsion Laboratory, with the support of Lockheed Martin Advanced Technology Center (LM ATC) and Northrop Grumman Space Technology (NGST), has addressed these challenges with a technology development program that is now complete. The requirements for SIM have been satisfied, based on outside peer review, using a series of laboratory tests and appropriate computer simulations: laser metrology systems perform with 10 picometer precision; mechanical vibrations have been controlled to nanometers, demonstrating orders of magnitude disturbance rejection; and knowledge of

  15. SIM Planetquest Science and Technology: A Status Report

    NASA Technical Reports Server (NTRS)

    Edberg, Stephen J.; Laskin, Robert A.; Marr, James C., IV; Unwin, Stephen C.; Shao, Michael

    2007-01-01

    Optical interferometry will open new vistas for astronomy over the next decade. The Space Interferometry Mission (SIM-PlanetQuest), operating unfettered by the Earth's atmosphere, will offer unprecedented astrometric precision that promises the discovery of Earth-analog extra-solar planets as well as a wealth of important astrophysics. Results from SIM will permit the determination of stellar masses to accuracies of 2% or better for objects ranging from brown dwarfs through main sequence stars to evolved white dwarfs, neutron stars, and black holes. Studies of star clusters will yield age determinations and internal dynamics. Microlensing measurements will present the mass spectrum of the Milky Way internal to the Sun while proper motion surveys will show the Sun's orbital radius and speed. Studies of the Galaxy's halo component and companion dwarf galaxies permit the determination of the Milky Way's mass distribution, including its Dark Matter component and the mass distribution and Dark Matter component of the Local Group. Cosmology benefits from precision (1-2%) determination of distances to Cepheid and RR Lyrae standard candles. The emission mechanism of supermassive black holes will be investigated. Finally, radio and optical celestial reference frames will be tied together by an improvement of two orders of magnitude. Optical interferometers present severe technological challenges. The Jet Propulsion Laboratory, with the support of Lockheed Martin Advanced Technology Center (LM ATC) and Northrop Grumman Space Technology (NGST), has addressed these challenges with a technology development program that is now complete. The requirements for SIM have been satisfied, based on outside peer review, using a series of laboratory tests and appropriate computer simulations: laser metrology systems perform with 10 picometer precision; mechanical vibrations have been controlled to nanometers, demonstrating orders of magnitude disturbance rejection; and knowledge of

  16. SIM Planetquest Science and Technology: A Status Report

    NASA Technical Reports Server (NTRS)

    Edberg, Stephen J.; Laskin, Robert A.; Marr, James C., IV; Unwin, Stephen C.; Shao, Michael

    2007-01-01

    Optical interferometry will open new vistas for astronomy over the next decade. The Space Interferometry Mission (SIM-PlanetQuest), operating unfettered by the Earth's atmosphere, will offer unprecedented astrometric precision that promises the discovery of Earth-analog extra-solar planets as well as a wealth of important astrophysics. Results from SIM will permit the determination of stellar masses to accuracies of 2% or better for objects ranging from brown dwarfs through main sequence stars to evolved white dwarfs, neutron stars, and black holes. Studies of star clusters will yield age determinations and internal dynamics. Microlensing measurements will present the mass spectrum of the Milky Way internal to the Sun while proper motion surveys will show the Sun's orbital radius and speed. Studies of the Galaxy's halo component and companion dwarf galaxies permit the determination of the Milky Way's mass distribution, including its Dark Matter component and the mass distribution and Dark Matter component of the Local Group. Cosmology benefits from precision (1-2%) determination of distances to Cepheid and RR Lyrae standard candles. The emission mechanism of supermassive black holes will be investigated. Finally, radio and optical celestial reference frames will be tied together by an improvement of two orders of magnitude. Optical interferometers present severe technological challenges. The Jet Propulsion Laboratory, with the support of Lockheed Martin Advanced Technology Center (LM ATC) and Northrop Grumman Space Technology (NGST), has addressed these challenges with a technology development program that is now complete. The requirements for SIM have been satisfied, based on outside peer review, using a series of laboratory tests and appropriate computer simulations: laser metrology systems perform with 10 picometer precision; mechanical vibrations have been controlled to nanometers, demonstrating orders of magnitude disturbance rejection; and knowledge of

  17. Cytogenetic analysis of interphase cells using spectral imaging [SIm] technology

    NASA Astrophysics Data System (ADS)

    Weier, Heinz-Ulli G.; Smida, Jan; Zitzelsberger, Horst; Lersch, Robert A.; Hung, Jamie; Hsieh, H. B.; Salassidis, K.; McNamara, George; Pedersen, Roger A.; Fung, Jingly

    2000-03-01

    Spectral Imaging (SIm) has dramatically improved our ability to localize and quantitatively analyze multiple nucleic acid targets such as chromosomes, genes and gene transcripts. Studies on metaphase cells such as `Spectral Karyotyping' are less complicated than interphase cell studies because the objects (chromosomes) are spatially separated and ratio- labeled probes can be used to uniquely stain each chromosome type. Our research, however, targets the extensive cytogenetic and phenotypic analysis of interphase cells. The complex organization of interphase chromatin and co- localization of gene transcripts (RNAs) in nuclear or cytoplasmic domains requires unique fluorochrome-labeling for each nucleic acid target. An increasing number of commercially available dyes for probe labeling and software to deconvolute partially overlapping emission spectra has helped to overcome most of these obstacles. This presentation summarizes our experience in analyzing numerical and structural alterations in various human cell types (leukocytes, amniocytes, blastomeres or solid tissue) as well as our approach to multi-gene expression profiling using SIm. Examples illustrate a wide spectrum of groundbreaking techniques for interphase cell analysis. We demonstrate how ten or more chromosomes can be scored in interphase nuclei or the relative level of expression of different transforming RNAs in tumor cells can be measured by SIm.

  18. SIMS analysis: Development and evaluation 1995 summary report

    SciTech Connect

    Groenewold, G.S.; Appelhans, A.D.; Ingram, J.C.; Delmore, J.E.; Dahl, D.A.

    1995-10-01

    Secondary ion mass spectrometry (SIMS) was evaluated for characterizing Hg salts. It was found that sulfate and chloride species could be identified directly without sample preparation. Mercuric oxide could be identified by complexation with formic acid. Hg nitrates could be identified by complexation with cyclohexylamine (CHA). Laser desorption ion trap MS was evaluated for characterizing EDTA on environmental samples. No intact EDTA ions were observed, but a series of EDTA fragment ions were visible, particularly on basalt and soil. An ion trap SIMS was developed: a perrhenate ion gun was interfaced to a Teledyne ion trap spectrometer, and the entire device was mounted on a cart. The technology was demonstrated using a prototype ion trap SIMS instrument for detecting Hg{center_dot}CHA complexes formed from nitrate salts. Intensity of the ion gun was improved, and the surface damage of the particle was small, and ion gun technology transfer to Phi-Evans, Inc. is being considered. Two technology end users are at INEL`s Central Facilities Area 674 pond and acid pit of the Radioactive Waste Management Complex; target problem at both sites is the need for Hg speciation on soil samples.

  19. The Effect of Companions on the SIM Reference Frame

    NASA Technical Reports Server (NTRS)

    Jacobs, Christopher S.; Turyshev, Slava G.

    2000-01-01

    The Space Interferometry Mission (SIM) is a 10-m Michelson space-based optical interferometer designed for precision astrometry (4 microarcseconds, 3 microarcseconds/year) with better accuracy than before over a narrow field of view. One of the primary objectives of the SIM instrument is to determine accurately the directions to a grid of stars, together with their proper motions and parallax, improving a priori knowledge by nearly three orders of magnitude over Hipparcos and one order of magnitude over FAME's planned accuracy (Johnston, 2000). The instrument does not measure directly the angular separation between stars, but rather it measures the projection of each star's direction vector onto the interferometer baseline vector by measuring the pathlength delay of starlight as it passes through the two arms of the interferometer. The accuracy and stability of SIM's celestial reference frame is subject to degradation over the 5-year mission from the reflex motion induced by massive companions of the objects used to construct the celestial reference frame. The authors present the results of simulations that show the sensitivity of reference frame accuracy to companions as a function of mass and period. They assume that pre-launch ground surveys will eliminate all objects with RMS radial velocity greater than 10 m/s. They further assume that the standard astrometric parameters of position, parallax, and proper motion plus acceleration terms in right ascension and declination will be allowed to absorb reflex motion.

  20. Exploratory analysis of TOF-SIMS data from biological surfaces

    NASA Astrophysics Data System (ADS)

    Vaidyanathan, Seetharaman; Fletcher, John S.; Henderson, Alex; Lockyer, Nicholas P.; Vickerman, John C.

    2008-12-01

    The application of multivariate analytical tools enables simplification of TOF-SIMS datasets so that useful information can be extracted from complex spectra and images, especially those that do not give readily interpretable results. There is however a challenge in understanding the outputs from such analyses. The problem is complicated when analysing images, given the additional dimensions in the dataset. Here we demonstrate how the application of simple pre-processing routines can enable the interpretation of TOF-SIMS spectra and images. For the spectral data, TOF-SIMS spectra used to discriminate bacterial isolates associated with urinary tract infection were studied. Using different criteria for picking peaks before carrying out PC-DFA enabled identification of the discriminatory information with greater certainty. For the image data, an air-dried salt stressed bacterial sample, discussed in another paper by us in this issue, was studied. Exploration of the image datasets with and without normalisation prior to multivariate analysis by PCA or MAF resulted in different regions of the image being highlighted by the techniques.

  1. Hanford Soil Inventory Model (SIM) Rev. 1 Users Guide

    SciTech Connect

    Simpson, Brett C.; Corbin, Rob A.; Anderson, Michael J.; Kincaid, Charles T.

    2006-09-25

    The focus of the development and application of a soil inventory model as part of the Remediation and Closure Science (RCS) Project managed by PNNL was to develop a probabilistic approach to estimate comprehensive, mass balanced-based contaminant inventories for the Hanford Site post-closure setting. The outcome of this effort was the Hanford Soil Inventory Model (SIM). This document is a user's guide for the Hanford SIM. The principal project requirement for the SIM was to provide comprehensive quantitative estimates of contaminant inventory and its uncertainty for the various liquid waste sites, unplanned releases, and past tank farm leaks as a function of time and location at Hanford. The majority, but not all of these waste sites are in the 200 Areas of Hanford where chemical processing of spent fuel occurred. A computer model capable of performing these calculations and providing satisfactory quantitative output representing a robust description of contaminant inventory and uncertainty for use in other subsequent models was determined to be satisfactory to address the needs of the RCS Project. The ability to use familiar, commercially available software on high-performance personal computers for data input, modeling, and analysis, rather than custom software on a workstation or mainframe computer for modeling, was desired.

  2. Probing Aqueous Surfaces by ToF-SIMS

    SciTech Connect

    Yu, Xiao-Ying; Yang, Li; Zhu, Zihua; Cowin, James P.; Iedema, Martin J.

    2011-10-01

    We report the first observations of aqueous surfaces by a time-of-flight secondary ion mass spectrometer (ToF-SIMS) via a self-contained microfluidic module compatible in vacuum. The interface uses a microfluidic channel with a 3 {micro}m diameter window into the flowing fluid beneath it. This window supports the liquid against the vacuum by the liquid's surface tension and limits the high-density vapor region traversed by the probe beams to only a few micrometers. We demonstrate detections of aqueous surfaces such as deuterium water and sodium iodide (NaI) solution through the small aperture by ToF-SIMS. Even more, molecular signals (M-H-) of glutamic acid (C5H8NO4-) are observed. ToF-SIMS coupled with the novel interface provides a molecular recognition capability, making it a great choice to detect short-lifetime reaction intermediates in aqueous solutions. This novel microfluidic interface makes multimodal vacuum based analysis of liquid surface possible.

  3. Identification of Mineral Phases on Basalt Surfaces by Imaging SIMS.

    PubMed

    Ingram, J C; Groenewold, G S; Olson, J E; Gianotto, A K; McCurry, M O

    1999-05-01

    A method for the identification of mineral phases on basalt surfaces utilizing secondary ion mass spectrometry (SIMS) with imaging capability is described. The goal of this work is to establish the use of imaging SIMS for characterization of the surface of basalt. The basalt surfaces were examined by interrogating the intact basalt (heterogeneous mix of mineral phases) as well as mineral phases that have been separated from the basalt samples. Mineral separates from the basalt were used to establish reference spectra for the specific mineral phases. Electron microprobe and X-ray photoelectron spectroscopy were used as supplemental techniques for providing additional characterization of the basalt. Mineral phases that make up the composition of the basalt were identified from single-ion images which were statistically grouped. The statistical grouping is performed by utilizing a program that employs a generalized learning vector quantization technique. Identification of the mineral phases on the basalt surface is achieved by comparing the mass spectra from the statistically grouped regions of the basalt to the mass spectral results from the mineral separates. The results of this work illustrate the potential for using imaging SIMS to study adsorption chemistry at the top surface of heterogeneous mineral samples.

  4. Investigations of corrosion phenomena on gold coins with SIMS

    NASA Astrophysics Data System (ADS)

    Mayerhofer, K. E.; Piplits, K.; Traum, R.; Griesser, M.; Hutter, H.

    2005-09-01

    In order to establish a new handling procedure for contaminated coins, the Coin Cabinet and the Conservation Science Department of the Kunsthistorisches Museum, Vienna, initiated a research project on corrosion effects of gold coins. By now, investigations on historic and contemporary coins included optical microscopy, scanning electron microscopy (SEM), Auger electron microscopy (AES), X-ray photoelectron microscopy (XPS), and electrochemical methods showing the distribution of pollutants. This work focuses on secondary ion mass spectrometry (SIMS) investigations merely showing the distribution of electronegative elements, such as sulfur, oxygen, and chlorine on the surface. Sulfur is highly suspected of causing the observed corrosion phenomena, and is indeed enriched near polluting splints. Since SIMS is a destructive method, the investigated samples are test coins with intentionally added impurities. These coins were manufactured in cooperation with the Austrian Mint. They were treated with potassium polysulfide (K 2S x) for 8 h gaining a rapid corrosion of the surface. SIMS mass spectra, depth profiles, and images were done (a) at non-polluted areas, (b) near polluted areas with slight coloring, and (c) directly at polluting stains showing enrichments of sulfur and chlorine. Due to the success of these investigations further studies on historic coins are intended.

  5. SIM-Lite Mission Spectral Calibration Sensitivities and Refinements

    NASA Technical Reports Server (NTRS)

    Zhai, C.; An, X.; Goullioud, R.; Nemati, B.; Shao, M.; Shen, J.; Wehmeier, U.; Wang, X.; Weiler, M.; Werne, T.; hide

    2010-01-01

    SIM-Lite missions will perform astrometry at microarcsecond accuracy using star light interferometry. For typical baselines that are shorter than 10 meters, this requires to measure optical path difference (OPD) accurate to tens of picometers calling for highly accurate calibration. A major challenge is to calibrate the star spectral dependency in fringe measurements -- the spectral calibration. Previously, we have developed a spectral calibration and estimation scheme achieving picometer level accuracy. In this paper, we present the improvements regarding the application of this scheme from sensitivity studies. Data from the SIM Spectral Calibration Development Unit (SCDU) test facility shows that the fringe OPD is very sensitive to pointings of both beams from the two arms of the interferometer. This sensitivity coupled with a systematic pointing error provides a mechanism to explain the bias changes in 2007. Improving system alignment can effectively reduce this sensitivity and thus errors due to pointing errors. Modeling this sensitivity can lead to further improvement in data processing. We then investigate the sensitivity to a model parameter, the bandwidth used in the fringe model, which presents an interesting trade between systematic and random errors. Finally we show the mitigation of calibration errors due to system drifts by interpolating instrument calibrations. These improvements enable us to use SCDU data to demonstrate that SIM-Lite missions can meet the 1pm noise floor requirement for detecting earth-like exoplanets.

  6. TankSIM: A Cryogenic Tank Performance Prediction Program

    NASA Technical Reports Server (NTRS)

    Bolshinskiy, L. G.; Hedayat, A.; Hastings, L. J.; Moder, J. P.; Schnell, A. R.; Sutherlin, S. G.

    2015-01-01

    Accurate prediction of the thermodynamic state of the cryogenic propellants in launch vehicle tanks is necessary for mission planning and successful execution. Cryogenic propellant storage and transfer in space environments requires that tank pressure be controlled. The pressure rise rate is determined by the complex interaction of external heat leak, fluid temperature stratification, and interfacial heat and mass transfer. If the required storage duration of a space mission is longer than the period in which the tank pressure reaches its allowable maximum, an appropriate pressure control method must be applied. Therefore, predictions of the pressurization rate and performance of pressure control techniques in cryogenic tanks are required for development of cryogenic fluid long-duration storage technology and planning of future space exploration missions. This paper describes an analytical tool, Tank System Integrated Model (TankSIM), which can be used for modeling pressure control and predicting the behavior of cryogenic propellant for long-term storage for future space missions. It is written in the FORTRAN 90 language and can be compiled with any Visual FORTRAN compiler. A thermodynamic vent system (TVS) is used to achieve tank pressure control. Utilizing TankSIM, the following processes can be modeled: tank self-pressurization, boiloff, ullage venting, and mixing. Details of the TankSIM program and comparisons of its predictions with test data for liquid hydrogen and liquid methane will be presented in the final paper.

  7. SimVascular: An Open Source Pipeline for Cardiovascular Simulation.

    PubMed

    Updegrove, Adam; Wilson, Nathan M; Merkow, Jameson; Lan, Hongzhi; Marsden, Alison L; Shadden, Shawn C

    2017-03-01

    Patient-specific cardiovascular simulation has become a paradigm in cardiovascular research and is emerging as a powerful tool in basic, translational and clinical research. In this paper we discuss the recent development of a fully open-source SimVascular software package, which provides a complete pipeline from medical image data segmentation to patient-specific blood flow simulation and analysis. This package serves as a research tool for cardiovascular modeling and simulation, and has contributed to numerous advances in personalized medicine, surgical planning and medical device design. The SimVascular software has recently been refactored and expanded to enhance functionality, usability, efficiency and accuracy of image-based patient-specific modeling tools. Moreover, SimVascular previously required several licensed components that hindered new user adoption and code management and our recent developments have replaced these commercial components to create a fully open source pipeline. These developments foster advances in cardiovascular modeling research, increased collaboration, standardization of methods, and a growing developer community.

  8. Unraveling the history of complex zoned garnets from the North Motagua Mélange (Guatemala)

    NASA Astrophysics Data System (ADS)

    Barickman, M. H.; Martin, C.; Flores, K. E.; Harlow, G. E.; Bonnet, G.

    2016-12-01

    The Guatemala Suture Zone (GSZ) is situated in central Guatemala, between the North American and Caribbean plates. Two serpentinite mélanges straddle the Motagua Fault system: the North Motagua Mélange (NMM) and the South Motagua Mélange (SMM). In this study, chemically zoned garnet grains from four eclogite blocks from the NMM were analyzed by EMPA for major elements and LA-ICP-MS for trace elements to unravel the geological history of the eclogites. These eclogites typically consist of euhedral to subhedral garnets, partly retrogressed omphacite grains, and accessory minerals such as phengite and epidote as inclusions in garnet. EBSD was employed to examine apparent garnet inclusions in garnet. The garnet grains in NMM eclogites display complex chemical zonations: all grains roughly show a spessartine-rich core, an almandine-rich core and/or intermediate zone, and a pyrope and grossular-rich rim. Additionally, crystal resorption can be observed between the different zones, and the pyrope-grossular rim can display oscillatory zoning. Finally, grossular-rich zones (crystallographically syntactic) within garnet are present in all studied samples. REE and spider diagrams do not show any significant difference in the patterns of the different zones within the garnet, or indicating that the chemical environment from which each garnet zone grew was broadly the same. The lack of significant variation in LILE content indicates that a fluid influx during garnet growth is unlikely. Consequently, we interpret that garnet grains grew in a largely closed system; however, the presence of the grossular-rich zones, argues for occasional excursions into conditions when either two garnets crystallized or Ca-rich overgrowths that were largely resorbed prior to subsequent continued garnet growth.

  9. Detrital zircon provenance link of the Chinle Formation and the Auld Lang Syne Group in Nevada

    SciTech Connect

    Gehrels, G.E.; Dickinson, W.R. . Dept of Geosciences); Riggs, N. . Dept of Geology)

    1993-04-01

    Previous workers have interpreted the Upper Triassic Auld Lang Syne Group of northwest Nevada as (a) part of a suspect terrane displaced with respect to the craton, or (b) the deltaic terminus of the Chinle depositional system of the Colorado Plateau. U-Pb ages for detrital zircons (air-abraded and analyzed as individual crystals), from sandstones in basal Chinle Fm near Currie and the Osobb Fm (basal Auld Lang Syne Gp) in Dixie Valley, set constraints on the provenance of the two units as follows: (a) Chinle grains (n = 40): 225--235 (n = 2), 505--525 (n = 19), 1,410--1,440 (n = 9), 1,700--1,740 (n = 4); (b) Osobb grains (n = 40): [approximately]235 (n = 1), [approximately]265 (n = 1), 355--415 (n = 3), 510--530 (n = 5), 1,010--1,080 (n = 11), [approximately]1,160 (n = 1), 1,430--1,450 (n = 7), 1,705--1,730 (n = 3). Proterozoic grains were likely shed from basement rocks in the SW US, whereas Triassic grains in both samples and Silurian-Devonian and Permian grains in the Osobb sample may have come from arc terranes to the south (Chinle) or west (Osobb). The Chinle sand is quartzose with only rare chert-quartzite grains, whereas the Osobb sand is subarkosic with chert-argillite and feldspar grains that presumably reflect the admixture of Grenville-age detritus (1,010--1,160 Ma) of uncertain provenance. The most likely source for Cambrian grains (505--530 Ma) is the rift-related igneous province stretching from southern Colorado to SW Oklahoma (Wichita Mtns). Regardless of origin, the unexpected occurrence of Cambrian grains in both Nevada samples supports the suggestion of Lupe and Silberling (1985) that the Auld Lang Syne Gp was deposited as a linked facies equivalent of the Chinle Fm.

  10. Utilizing "The William Allan Kritsonis Balanced Teeter-Totter Model" as a Means to Cultivate a Legacy of Transformational Leaders in Schools: A National Focus

    ERIC Educational Resources Information Center

    Jacobs, Karen Dupre

    2007-01-01

    The Kritsonis Teeter-Totter Model, developed by Dr. William Allan Kritsonis, is utilized to cultivate a legacy of transformational leaders in schools throughout the United States. In a time when change in schools is inevitable, the model aides school leaders in better defining their individual role in schools and that of their stakeholders in…

  11. Rare variants in single-minded 1 (SIM1) are associated with severe obesity

    PubMed Central

    Ramachandrappa, Shwetha; Raimondo, Anne; Cali, Anna M.G.; Keogh, Julia M.; Henning, Elana; Saeed, Sadia; Thompson, Amanda; Garg, Sumedha; Bochukova, Elena G.; Brage, Soren; Trowse, Victoria; Wheeler, Eleanor; Sullivan, Adrienne E.; Dattani, Mehul; Clayton, Peter E.; Datta, Vippan; Bruning, John B.; Wareham, Nick J.; O’Rahilly, Stephen; Peet, Daniel J.; Barroso, Ines; Whitelaw, Murray L.; Farooqi, I. Sadaf

    2013-01-01

    Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in Sim1 haploinsufficient mice and in a patient with a balanced translocation disrupting SIM1. We sequenced the coding region of SIM1 in 2,100 patients with severe, early onset obesity and in 1,680 controls. Thirteen different heterozygous variants in SIM1 were identified in 28 unrelated severely obese patients. Nine of the 13 variants significantly reduced the ability of SIM1 to activate a SIM1-responsive reporter gene when studied in stably transfected cells coexpressing the heterodimeric partners of SIM1 (ARNT or ARNT2). SIM1 variants with reduced activity cosegregated with obesity in extended family studies with variable penetrance. We studied the phenotype of patients carrying variants that exhibited reduced activity in vitro. Variant carriers exhibited increased ad libitum food intake at a test meal, normal basal metabolic rate, and evidence of autonomic dysfunction. Eleven of the 13 probands had evidence of a neurobehavioral phenotype. The phenotypic similarities between patients with SIM1 deficiency and melanocortin 4 receptor (MC4R) deficiency suggest that some of the effects of SIM1 deficiency on energy homeostasis are mediated by altered melanocortin signaling. PMID:23778139

  12. Generation of alkaline magmas in subduction zones by melting of mélange diapirs

    NASA Astrophysics Data System (ADS)

    Cruz-Uribe, A. M.; Marschall, H.; Gaetani, G. A.; Le Roux, V.

    2016-12-01

    Alkaline lavas occur globally in subduction-related volcanic arcs. Existing explanations for the occurrence of alkaline lavas in volcanic arcs invoke at least one - and in some cases multiple - `metasomatic' events in addition to the traditional three-component mixing of altered oceanic crust (AOC), sediment melt, and depleted mantle, in order to explain the range of rock types found in a given region. These multi-stage models posit the existence of metasomatized mantle wedge peridotite containing phlogopite or amphibole-enriched veins, which partially melt when fluxed by the addition of materials from the subducted slab. The mélange diapir model is informed by observations and modeling of the subduction side of the arc system, and predicts the generation of alkaline arc magmas by advection of buoyant material from the slab-wedge interface into the mantle wedge below arcs. Here we report results from experiments in which natural mélange materials partially melted at upper mantle conditions were found to produce alkaline magmas compositionally similar to those found in arcs worldwide. The starting material for our experiments is a chlorite-omphacite fels (SY400) from the island of Syros, Greece, that is representative of a hybrid rock containing AOC, sediment, and mantle components. Melting experiments were performed using a piston cylinder apparatus at conditions relevant to the heating-decompression path of mélange diapirs (1000-1300 °C, 1.5-2.5 GPa). The compositions of experimentally produced melts range from 51-61 wt% SiO2, and fall within the trachyte and tephrite-phonolite series (7.5-12.9 wt% Na2O+K2O). Restitic phases in equilibrium with melt include clinopyroxene, garnet (at high P), phlogopite (at high P), amphibole, olivine, rutile, and ilmenite. Partial melts produced in our experiments have trace-element abundance patterns that are typical of alkaline arc lavas, such as enrichment in large ion lithophile elements (Cs, Rb, Ba, Pb, Sr) and alkalis (K

  13. Paracercion ambiguum sp. nov. from Lang Son, Vietnam (Zygoptera: Coenagrionidae).

    PubMed

    Ning, Xin; Kompier, Tom; Yu, Xin; Bu, Wenjun

    2016-07-27

    One new species of Paracercion Weekers and Dumont, 2004 (Paracercion ambiguum Kompier & Yu, 2016, holotype male, Vietnam, Lang Son province, Huu Lien Nature Reserve, 1-XII-2013, deposited in Institute of Entomology, College of Life Sciences of Nankai University, Tianjin, China) is proposed on the basis of molecular and morphological evidence. A COI gene tree is presented for Paracercion species and several morphologically related genera. The species is described and illustrated for both sexes. Diagnostic figures of the genital ligula and caudal appendages are provided.

  14. Dental Management of Cornelia de Lange Syndrome: A Rare Case Report

    PubMed Central

    Nagpal, Mehak; Gulia, Shweta; Sachdev, Vinod

    2015-01-01

    Cornelia de Lange syndrome (CdLS) is a rare, multiple congenital defect often called as Amsterdam dwarfism. The physical phenotype of CdLS includes low birth body weight, short stature and facio-cranial dysmorphia. The diagnosis of the syndrome is based on clinical grounds as there is no biochemical or chromosomal markers for CDLS that makes its diagnosis more complicated. The purpose of this paper is to present a clinical report of a boy emphasizing the importance of multidisciplinary approach for the diagnosis and treatment of this syndrome. PMID:25859533

  15. Brachmann-de Lange syndrome: Autosomal dominant inheritance and male-to-male transmission

    SciTech Connect

    McKenney, R.R.; Elder, F.F.B.; Northrup, H.; Garcia, J.

    1996-12-30

    We report on familial occurrence of the Brachmann-de Lange syndrome (BDLS): a mildly affected father and his severely affected son and daughter who have different mothers. Both children are severely affected while the father has a much milder but definite BDLS phenotype. Our report documents the third example of male-to-male transmission and adds to the argument against exclusively maternal transmission in familial cases. In addition, our findings illustrate the occurrence of severe manifestations in cases of familial BDLS. 29 refs., 3 figs.

  16. Cornelia De Lange syndrome: a case report of a Brazilian boy.

    PubMed

    Scarpelli, Ana C; Pordeus, Isabela A; Resende, Vera L; Castilho, Lia S; Marques, Leandro S; Paiva, Saul M

    2011-07-01

    Cornelia de Lange syndrome is a rare multisystem disorder characterized by a distinctive facial appearance, delayed growth and psychomotor skills, behavioral problems, malformation of the upper limbs, and impairment on the quality of life of affected subjects. This article reports a case of a child with the syndrome, emphasizing the orofacial manifestations. Knowledge on the etiopathological aspects and characteristic features of this condition is essential so that professionals can provide health care and help improve the quality of life of affected individuals and their families.

  17. Cornelia de Lange and Ehlers-Danlos: comorbidity of two rare syndromes.

    PubMed

    Cravero, Cora; Guinchat, Vincent; Barete, Stéphane; Consoli, Angèle

    2016-02-01

    We present a case of a young adult with both Cornelia de Lange syndrome and Ehlers-Danlos syndrome. The patient showed non-verbal autism, intellectual disability and severe/intractable self-harming behaviours that led to a life-threatening complication (ie, septicaemia). A significant reduction in the self-harming behaviours was attained in a multidisciplinary neurobehavioural inpatient unit after addressing all causes of somatic pains, managing pain using level II and III analgesics, stabilising the patient's mood, limiting the iatrogenic effects of multiple prescriptions and offering a specific psychoeducational approach.

  18. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression

    PubMed Central

    Tolson, KP; Gemelli, T; Gautron, L; Elmquist, JK; Zinn, AR; Kublaoui, BM

    2010-01-01

    Single-minded 1 (SIM1) mutations are one of the few known causes of nonsyndromic monogenic obesity in both humans and mice. While the role of Sim1 in the formation of the hypothalamus has been described, its post-developmental, physiologic functions have not been well established. Here we demonstrate that postnatal CNS deficiency of Sim1 is sufficient to cause hyperphagic obesity. We conditionally deleted Sim1 after birth using α-calcium/calmodulin-dependent protein kinase II-Cre (CamKII-Cre) lines to recombine a floxed Sim1 allele. Conditional Sim1 heterozygotes phenocopied germline Sim1 heterozygotes, displaying hyperphagic obesity and increased length. We also generated viable conditional Sim1 homozygotes, demonstrating that adult Sim1 expression is not essential for mouse or neuron survival, and revealing a dosage-dependent effect of Sim1 on obesity. Using stereologic cell counting, we showed that the phenotype of both germline heterozygotes and conditional Sim1 homozygotes was not attributable to global hypocellularity of the paraventricular nucleus (PVN) of the hypothalamus. We also used retrograde tract tracing to demonstrate that the PVN of germline heterozygous mice projects normally to the dorsal vagal complex (DVC) and the median eminence (ME). Finally, we showed that conditional Sim1 homozygotes exhibit a remarkable decrease in hypothalamic oxytocin (Oxt) and PVN melanocortin 4 receptor (Mc4r) mRNA. These results demonstrate that the role of Sim1 in feeding regulation is not limited to formation of the PVN or its projections, and that the hyperphagic obesity in Sim1 deficient mice may be attributable to changes in the leptin-melanocortin-oxytocin pathway. PMID:20220015

  19. Alternative Liquid Fuels Simulation Model (AltSim).

    SciTech Connect

    Williams, Ryan; Baker, Arnold Barry; Drennen, Thomas E.

    2009-12-01

    The Alternative Liquid Fuels Simulation Model (AltSim) is a high-level dynamic simulation model which calculates and compares the production and end use costs, greenhouse gas emissions, and energy balances of several alternative liquid transportation fuels. These fuels include: corn ethanol, cellulosic ethanol from various feedstocks (switchgrass, corn stover, forest residue, and farmed trees), biodiesel, and diesels derived from natural gas (gas to liquid, or GTL), coal (coal to liquid, or CTL), and coal with biomass (CBTL). AltSim allows for comprehensive sensitivity analyses on capital costs, operation and maintenance costs, renewable and fossil fuel feedstock costs, feedstock conversion ratio, financial assumptions, tax credits, CO{sub 2} taxes, and plant capacity factor. This paper summarizes the structure and methodology of AltSim, presents results, and provides a detailed sensitivity analysis. The Energy Independence and Security Act (EISA) of 2007 sets a goal for the increased use of biofuels in the U.S., ultimately reaching 36 billion gallons by 2022. AltSim's base case assumes EPA projected feedstock costs in 2022 (EPA, 2009). For the base case assumptions, AltSim estimates per gallon production costs for the five ethanol feedstocks (corn, switchgrass, corn stover, forest residue, and farmed trees) of $1.86, $2.32, $2.45, $1.52, and $1.91, respectively. The projected production cost of biodiesel is $1.81/gallon. The estimates for CTL without biomass range from $1.36 to $2.22. With biomass, the estimated costs increase, ranging from $2.19 per gallon for the CTL option with 8% biomass to $2.79 per gallon for the CTL option with 30% biomass and carbon capture and sequestration. AltSim compares the greenhouse gas emissions (GHG) associated with both the production and consumption of the various fuels. EISA allows fuels emitting 20% less greenhouse gases (GHG) than conventional gasoline and diesels to qualify as renewable fuels. This allows several of the CBTL

  20. Automated SIMS Isotopic Analysis Of Small Dust Particles

    NASA Astrophysics Data System (ADS)

    Nittler, L.; Alexander, C.; Gyngard, F.; Morgand, A.; Zinner, E. K.

    2009-12-01

    The isotopic compositions of sub-μm to μm sized dust grains are of increasing interest in cosmochemistry, nuclear forensics and terrestrial aerosol research. Because of its high sensitivity and spatial resolution, Secondary Ion Mass Spectrometry (SIMS) is the tool of choice for measuring isotopes in such small samples. Indeed, SIMS has enabled an entirely new sub-field of astronomy: presolar grains in meteorites. In recent years, the development of the Cameca NanoSIMS ion probe has extended the reach of isotopic measurements to particles as small as 100 nm in diameter, a regime where isotopic precision is strongly limited by the total number of atoms in the sample. Many applications require obtaining isotopic data on large numbers of particles, necessitating the development of automated techniques. One such method is isotopic imaging, wherein images of multiple isotopes are acquired, each containing multiple dispersed particles, and image processing is used to determine isotopic ratios for individual particles. This method is powerful, but relatively inefficient for raster-based imaging on the NanoSIMS. Modern computerized control of instrumentation has allowed for another approach, analogous to commercial automated SEM-EDS particle analysis systems, in which images are used solely to locate particles followed by fully automated grain-by-grain analysis. The first such system was developed on the Carnegie Institution’s Cameca ims-6f, and was used to generate large databases of presolar grains. We have recently developed a similar system for the NanoSIMS, whose high sensitivity allows for smaller grains to be analyzed with less sample consumption than is possible with the 6f system. The 6f and NanoSIMS systems are functionally identical: an image of dispersed grains is obtained with sufficient statistical precision for an algorithm to identify the positions of individual particles, the primary ion beam is deflected to each particle in turn and rastered in a small

  1. Controls on accretion of flysch and mélange belts at convergent margins: Evidence from the Chugach Bay thrust and Iceworm mélange, Chugach accretionary wedge, Alaska

    NASA Astrophysics Data System (ADS)

    Kusky, Timothy M.; Bradley, Dwight C.; Haeussler, Peter J.; Karl, Sue

    1997-12-01

    Controls on accretion of flysch and mélange terranes at convergent margins are poorly understood. Southern Alaska's Chugach terrane forms the outboard accretionary margin of the Wrangellia composite terrane, and consists of two major lithotectonic units, including Triassic-Cretaceous mélange of the McHugh Complex and Late Cretaceous flysch of the Valdez Group. The contact between the McHugh Complex and the Valdez Group on the Kenai Peninsula is a tectonic boundary between chaotically deformed melange of argillite, chert, greenstone, and graywacke of the McHugh Complex and a less chaotically deformed mélange of argillite and graywacke of the Valdez Group. We assign the latter to a new, informal unit of formational rank, the Iceworm mélange, and interpret it as a contractional fault zone (Chugach Bay thrust) along which the Valdez Group was emplaced beneath the McHugh Complex. The McHugh Complex had already been deformed and metamorphosed to prehnite-pumpellyite facies prior to formation of the Iceworm mélange. The Chugach Bay thrust formed between 75 and 55 Ma, as shown by Campanian-Maastrichtian depositional ages of the Valdez Group, and fault-related fabrics in the Iceworm mélange that are cut by Paleocene dikes. Motion along the Chugach Bay thrust thus followed Middle to Late Cretaceous collision (circa 90-100 Ma) of the Wrangellia composite terrane with North America. Collision related uplift and erosion of mountains in British Columbia formed a submarine fan on the Farallon plate, and we suggest that attempted subduction of this fan dramatically changed the subduction/accretion style within the Chugach accretionary wedge. We propose a model in which subduction of thinly sedimented plates concentrates shear strains in a narrow zone, generating mélanges like the McHugh in accretionary complexes. Subduction of thickly sedimented plates allows wider distribution of shear strains to accommodate plate convergence, generating a more coherent accretionary style

  2. Of moths and men: Theo Lang and the persistence of Richard Goldschmidt's theory of homosexuality, 1916-1960.

    PubMed

    Dietrich, M R

    2000-01-01

    Using an analogy between moths and men, in 1916, Richard Goldschmidt proposed that homosexuality was a case of genetic intersexuality. As he strove to create a unified theory of sex determination that would encompass animals ranging from moths to men, Goldschmidt's doubts grew concerning the association of homosexuality with intersexuality until, in 1931, he dropped homosexuality from his theory of intersexuality. Despite Goldschmidt's explicit rejection of his theory of homosexuality, Theo Lang, a researcher in the Genealogical-Demographic Department of the Institute for Psychiatric Research in Munich, revived it, maintained Goldschmidt's association with it, and argued on its behalf in publications from 1936 to 1960. Lang's appropriation of Goldschmidt's theory did not depend on his resolution of the difficulties Goldschmidt had found with his own theory. Lang and Goldschmidt, I argue, had fundamentally different scientific and social commitments that allowed one to reject this theory of homosexuality and the other to accept it.

  3. The Casanova Complex of the Northern Apennines: A mélange formed on a distal passive continental margin

    NASA Astrophysics Data System (ADS)

    Naylor, Michaél A.

    1982-01-01

    The Cretaceous-Palaeocene Casanova Complex occurs in two thrust sheets of the eugeosynclinal Ligurids of the Northern Apennines. It is a sedimentary mélange with ophiolitic and quartzose turbidites or limestone-shale olistostrome (submarine debris flows) as matrix. Exotic blocks of ophiolite and granite, serpentinite breccias and lenticular ophiolitic breccias and olistostromes contribute to the mélange character of the complex. Deformational structures include soft-sediment slump folds (indicating a SW-dipping palaeoslope) and boudins, a gradational slumped top to the mélange, small-scale faults in chert blocks and deformation associated with the emplacement of the exotic slide blocks. The blocks were shed as rotational slides from submarine fault scarps and are surrounded by haloes of debris created by submarine weathering. The stacking pattern of the blocks, with the originally stratigraphically highest ophiolite lithologies lowest in the pile of blocks, is explained by a diverticulation model with progressively deeper erosion. Mechanical analysis shows that the blocks were stable when partly exposed resting on a soft sediment substratum. Criteria which distinguish the Casanova Complex from a tectonic mélange, and which may be of value in other mélanges, are discussed. Previous interpretations of the complex as a precursor olistostrome to northeastward nappe emplacement (the Bracco ridge model) are rejected. The mélange is believed to have formed on ocean crust as a result of turbidite and debris flow sedimentation, soft sediment deformation, block faulting, gravity sliding and submarine erosion at the distal edge of a uniformly SW-dipping continental margin.

  4. CalSimHydro Tool - A Web-based interactive tool for the CalSim 3.0 Hydrology Prepropessor

    NASA Astrophysics Data System (ADS)

    Li, P.; Stough, T.; Vu, Q.; Granger, S. L.; Jones, D. J.; Ferreira, I.; Chen, Z.

    2011-12-01

    CalSimHydro, the CalSim 3.0 Hydrology Preprocessor, is an application designed to automate the various steps in the computation of hydrologic inputs for CalSim 3.0, a water resources planning model developed jointly by California State Department of Water Resources and United States Bureau of Reclamation, Mid-Pacific Region. CalSimHydro consists of a five-step FORTRAN based program that runs the individual models in succession passing information from one model to the next and aggregating data as required by each model. The final product of CalSimHydro is an updated CalSim 3.0 state variable (SV) DSS input file. CalSimHydro consists of (1) a Rainfall-Runoff Model to compute monthly infiltration, (2) a Soil moisture and demand calculator (IDC) that estimates surface runoff, deep percolation, and water demands for natural vegetation cover and various crops other than rice, (3) a Rice Water Use Model to compute the water demands, deep percolation, irrigation return flow, and runoff from precipitation for the rice fields, (4) a Refuge Water Use Model that simulates the ponding operations for managed wetlands, and (5) a Data Aggregation and Transfer Module to aggregate the outputs from the above modules and transfer them to the CalSim SV input file. In this presentation, we describe a web-based user interface for CalSimHydro using Google Earth Plug-In. The CalSimHydro tool allows users to - interact with geo-referenced layers of the Water Budget Areas (WBA) and Demand Units (DU) displayed over the Sacramento Valley, - view the input parameters of the hydrology preprocessor for a selected WBA or DU in a time series plot or a tabular form, - edit the values of the input parameters in the table or by downloading a spreadsheet of the selected parameter in a selected time range, - run the CalSimHydro modules in the backend server and notify the user when the job is done, - visualize the model output and compare it with a base run result, - download the output SV file to be

  5. Epileptic features in Cornelia de Lange syndrome: case report and literature review.

    PubMed

    Pavlidis, Elena; Cantalupo, Gaetano; Bianchi, Sara; Piccolo, Benedetta; Pisani, Francesco

    2014-11-01

    Cornelia de Lange syndrome is a rare genetic disease, caused by mutations in three known different genes: NIBPL (crom 5p), SMC1A (crom X) and SMC3 (crom 10q), that account for about 65% of cases. This syndrome is characterized by distinctive facial features, psychomotor delay, growth retardation since the prenatal period (second trimester of pregnancy), hands and feet abnormalities, and involvement of other organs/systems. SMC1A and SMC3 mutations are responsible for a mild phenotype of the syndrome. We report the electroclinical features of epilepsy in a child with a mild Cornelia de Lange syndrome and furthermore we reviewed the descriptions of the epileptic findings available in the literature in patients with such syndrome. A large heterogeneity of the epileptic findings in the literature is reported. The presence of epilepsy could be related to pathophysiological factors independent of those implicated in the characterization of main classical phenotypic features. A more detailed description of the epileptic findings could help clinicians in the diagnosis of this syndrome in those cases lacking of the typical features. Copyright © 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  6. Cornelia de lange syndrome with thyroid agenesis of an indonesian patient.

    PubMed

    Maskoen, A M; Laksono, B; Hajjah, R; Zada, A; Suciati, L P; Fauziah, P N; Nataprawira, H M

    2017-08-30

    Cornelia de Lange syndrome (CdLs), which is also called Brachmann de Lange syndrome, is a congenital disorder characterized by distinctive facial features, prenatal and postnatal growth deficiency, feeding difficulties, psychomotor delay, behavioral problems, and associated malformations that mainly involve the upper extremities. The prevalence ranges from 1:100,000 to as high as 1:10,000. Most cases (50-60%) were carried mutation in NIPBL gene. To our knowledge this is the first CdLs Indonesian case that reported with molecular analysis study. We present an 11 months old female Indonesian patient with classic CdLs with congenital hypothyroid. Genetics studies were performed in intron 1, exon 2, exon 10 and exon 22 of NIPBL gene. Thyroid studies (T3, T4, TSH and thyroid scan) were performed. Low level of T3 and T4, and high level of TSH were observed. Thyroid agenesis was found in thyroid scan examination. We detected thyroid agenesis which has been never reported in CdLs patients. We could not find any mutation in intron 1, exon 2, exon 10 and exon 22 of NIPBL gene. Further genetics examinations were necessary whether there is mutation in other locus.

  7. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction

    PubMed Central

    Braunholz, Diana; Hullings, Melanie; Gil-Rodríguez, María Concepcion; Fincher, Christopher T; Mallozzi, Mark B; Loy, Elizabeth; Albrecht, Melanie; Kaur, Maninder; Limon, Janusz; Rampuria, Abhinav; Clark, Dinah; Kline, Antonie; Dalski, Andreas; Eckhold, Juliane; Tzschach, Andreas; Hennekam, Raoul; Gillessen-Kaesbach, Gabriele; Wierzba, Jolanta; Krantz, Ian D; Deardorff, Matthew A; Kaiser, Frank J

    2012-01-01

    Cornelia de Lange syndrome (CdLS; or Brachmann-de Lange syndrome) is a dominantly inherited congenital malformation disorder with features that include characteristic facies, cognitive delays, growth retardation and limb anomalies. Mutations in nearly 60% of CdLS patients have been identified in NIPBL, which encodes a regulator of the sister chromatid cohesion complex. NIPBL, also known as delangin, is a homolog of yeast and amphibian Scc2 and C. elegans PQN-85. Although the exact mechanism of NIPBL function in sister chromatid cohesion is unclear, in vivo yeast and C. elegans experiments and in vitro vertebrate cell experiments have demonstrated that NIPBL/Scc2 functionally interacts with the MAU2/Scc4 protein to initiate loading of cohesin onto chromatin. To test the significance of this model in the clinical setting of CdLS, we fine-mapped the NIBPL–MAU2 interaction domain and tested the functional significance of missense mutations and variants in NIPBL and MAU2 identified in these minimal domains in a cohort of patients with CdLS. We demonstrate that specific novel mutations at the N-terminus of the MAU2-interacting domain of NIBPL result in markedly reduced MAU2 binding, although we appreciate no consistent clinical difference in the small group of patients with these mutations. These data suggest that factors in addition to MAU2 are essential in determining the clinical features and severity of CdLS. PMID:21934712

  8. Levator scapulae and rhomboid transfer for paralysis of trapezius. The Eden-Lange procedure.

    PubMed

    Romero, J; Gerber, C

    2003-11-01

    Spinal accessory nerve palsy leads to painful disability of the shoulder, carrying an uncertain prognosis. We reviewed the long-term outcome in 16 patients who were treated for pain, weakness of active elevation and asymmetry of the shoulder and the neck due to chronic paralysis of the trapezius muscle, as a result of nerve palsy. Of four patients who were treated conservatively, none regained satisfactory function, although two became pain-free. The other 12 patients were treated operatively with transfer of the levator scapulae to the acromion and the rhomboid muscles to the infraspinatus fossa (the Eden-Lange procedure). At a mean follow-up of 32 years, the clinical outcome of the operatively treated patients was excellent in nine, fair in two, and poor in one patient, as determined by the Constant score. Pain was adequately relieved in 11 and overhead function was restored in nine patients. Pre-operative electromyography had been carried out in four patients. In two, who eventually had a poor outcome, a concomitant long thoracic and dorsal scapular nerve lesion had been present. The Eden-Lange procedure gives very satisfactory long-term results for the treatment of isolated paralysis of trapezius. In the presence of an additional serratus anterior palsy or weak rhomboid muscles, the procedure is less successful in restoring shoulder function.

  9. Biomarkers in Tertiary mélange, western Olympic Peninsula, Washington, U.S.A.

    USGS Publications Warehouse

    Kvenvolden, Keith A.; Hostettler, Frances D.; Rapp, John B.; Snavely, Parke D.

    1991-01-01

    Middle Eocene to middle Miocene mélange and broken formations are exposed in the coastal outcrops along the west side of the Olympic Peninsula, Washington. A petroleum geochemical assessment of these geologic units has included the investigation of biomarker compounds. A comparison was made of biomarkers in an oil sample from a middle Miocene reservoir penetrated in the Medina No. 1 well with biomarkers in extracts from two samples of middle Eocene Ozette mélange (one sample having a strong petroliferous odor, and the other sample lacking this characteristic odor). Distribution patterns of n-alkanes, tricyclic terpanes, pentacyclic triterpanes, steranes, and diasteranes are remarkably similar in the oil and rock extracts. Biomarker maturity parameters indicate higher maturity in the oil relative to the extracts. The presence of 17α(H)-23,28-bisnorlupane, 18α(H)- and 18β(H)-oleanane, and de-A-lupane and an odd-carbon-number dominance of the n-alkanes in the oil and extracts seems to tie the hydrocarbons to a common source that has a significant terrigenous component.

  10. Inducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity.

    PubMed

    Tolson, Kristen P; Gemelli, Terry; Meyer, Donna; Yazdani, Umar; Kozlitina, Julia; Zinn, Andrew R

    2014-07-01

    Germline haploinsufficiency of human or mouse Sim1 is associated with hyperphagic obesity. Sim1 encodes a transcription factor required for proper formation of the paraventricular (PVN), supraoptic, and anterior periventricular hypothalamic nuclei. Sim1 expression persists in these neurons in adult mice, raising the question of whether it plays a physiologic role in regulation of energy balance. We previously showed that Sim1 heterozygous mice had normal numbers of PVN neurons that were hyporesponsive to melanocortin 4 receptor agonism and showed reduced oxytocin expression. Furthermore, conditional postnatal neuronal inactivation of Sim1 also caused hyperphagic obesity and decreased hypothalamic oxytocin expression. PVN projections to the hindbrain, where oxytocin is thought to act to modulate satiety, were anatomically intact in both Sim1 heterozygous and conditional knockout mice. These experiments provided evidence that Sim1 functions in energy balance apart from its role in hypothalamic development but did not rule out effects of Sim1 deficiency on postnatal hypothalamic maturation. To address this possibility, we used a tamoxifen-inducible, neural-specific Cre transgene to conditionally inactivate Sim1 in adult mice with mature hypothalamic circuitry. Induced Sim1 inactivation caused increased food and water intake and decreased expression of PVN neuropeptides, especially oxytocin and vasopressin, with no change in energy expenditure. Sim1 expression was not required for survival of PVN neurons. The results corroborate previous evidence that Sim1 acts physiologically as well as developmentally to regulate body weight. Inducible knockout mice provide a system for studying Sim1's physiologic function in energy balance and identifying its relevant transcriptional targets in the hypothalamus.

  11. The final days of Edgar Allan Poe: clues to an old mystery using 21st century medical science.

    PubMed

    Francis, Roger A

    This study examines all documented information regarding the final days and death of Edgar Allan Poe (1809-1849), in an attempt to determine the most likely cause of death of the American poet, short story writer, and literary critic. Information was gathered from letters, newspaper accounts, and magazine articles written during the period after Poe's death, and also from biographies and medical journal articles written up until the present. A chronology of Poe's final days was constructed, and this was used to form a differential diagnosis of possible causes of death. Death theories over the last 160 years were analyzed using this information. This analysis, along with a review of Poe's past medical history, would seem to support an alcohol-related cause of death.

  12. Regolith breccia Allan Hills A81005 - Evidence of lunar origin, and petrography of pristine and nonpristine clasts

    NASA Technical Reports Server (NTRS)

    Warren, P. H.; Taylor, G. J.; Keil, K.

    1983-01-01

    It is shown that the ratios of MnO/FeO in pyroxene, texture (abundant brown and swirly glass, which are typical of lunar regolith breccias) and overall composition (approximately 75 percent plagioclase) indicate a lunar origin for the regolith breccia Allan Hills A81005, presumably from an unsampled region of the moon. The rock is found to differ in detail from other regolith samples; for example, it has exceptionally low contents of Na and KREEP. In addition, a pristine clast is found to contain exceptionally coarse augite in comparison with similar Apollo samples. It is found that ALHA81005 is not perceptibly more shocked than typical Apollo regolith breccias. It is concluded that the discovery of this rock on earth strengthens the suggestion that SNC achondrites were derived by impact ejection from Mars.

  13. A 7-month-old male with Allan-Herndon-Dudley syndrome and the power of T3.

    PubMed

    Langley, Katherine G; Trau, Steven; Bean, Lora J H; Narravula, Alekhya; Schrier Vergano, Samantha A

    2015-05-01

    Allan-Herndon-Dudley syndrome (AHDS, MIM 300523) is an X-linked neurodegenerative disorder characterized by intellectual disability, severe hypotonia, diminished muscle mass, and progressive spastic paraplegia. All affected males have pathognomonic thyroid profiles with an elevated T3 , low-normal free T4 , and normal TSH. Mutations in the monocarboxylate transporter 8 (MCT8) gene, SLC16A2, have been found to be causative. Here, we describe a proband whose extensive evaluation and ultimate diagnosis of AHDS unmasked three previously undiagnosed generations of affected individuals in one family. This case illustrates the need for clinicians to consider obtaining full thyroid studies on individuals with the non-specific findings of severe hypotonia, failure to thrive, and gross motor delay.

  14. neXtSIM: a new Lagrangian sea ice model

    NASA Astrophysics Data System (ADS)

    Rampal, Pierre; Bouillon, Sylvain; Ólason, Einar; Morlighem, Mathieu

    2016-05-01

    The Arctic sea ice cover has changed drastically over the last decades. Associated with these changes is a shift in dynamical regime seen by an increase of extreme fracturing events and an acceleration of sea ice drift. The highly non-linear dynamical response of sea ice to external forcing makes modelling these changes and the future evolution of Arctic sea ice a challenge for current models. It is, however, increasingly important that this challenge be better met, both because of the important role of sea ice in the climate system and because of the steady increase of industrial operations in the Arctic. In this paper we present a new dynamical/thermodynamical sea ice model called neXtSIM that is designed to address this challenge. neXtSIM is a continuous and fully Lagrangian model, whose momentum equation is discretised with the finite-element method. In this model, sea ice physics are driven by the combination of two core components: a model for sea ice dynamics built on a mechanical framework using an elasto-brittle rheology, and a model for sea ice thermodynamics providing damage healing for the mechanical framework. The evaluation of the model performance for the Arctic is presented for the period September 2007 to October 2008 and shows that observed multi-scale statistical properties of sea ice drift and deformation are well captured as well as the seasonal cycles of ice volume, area, and extent. These results show that neXtSIM is an appropriate tool for simulating sea ice over a wide range of spatial and temporal scales.

  15. Star Confusion Effect on SIM PlanetQuest Astrometric Performance

    NASA Technical Reports Server (NTRS)

    Zhai, C.; Yu, M.; Milman, M.; Fathpour, N.; Morales, M.; Nemati, B.; Regehr, M.; Heflin, M.; Sievers, L.

    2007-01-01

    SIM PlanetQuest will measure star positions to an accuracy of a few microarcseconds using precise white light fringe measurements. One challenge for SIM observation scenario is "star confusion," where multiple stars are present in the instrument field of view. This is especially relevant for observing dim science targets because the density of number of stars increases rapidly with star magnitude. We study the effect of star confusion on the SIM astrometric performance due to systematic fringe errors caused by the extra photons from the confusion star(s}. Since star confusion from multiple stars may be analyzed as a linear superposition of the effect from single star confusion, we quantify the astrometric errors due to single star confusion surveying over many spectral types, including AOV, FOV, K5III, and MOV, and for various visual magnitude differences. To the leading order, the star confusion effect is characterized by the magnitude difference, spectral difference, and the angular separation between the target and confusion stars.Strategies for dealing with star confusion are presented. For example, since the presence of additional sources in the field of view leads to inconsistent delay estimates from different channels, with sufficient signal to noise ratio, the star confusion can be detected using chi-square statistics of fringe measurements from multiple spectral channels. An interesting result is that the star confusion can be detected even though the interferometer cannot resolve the separation between the target and confusion stars when their spectra are sufficiently different. Other strategies for mitigating the star confusion effect are also discussed.

  16. CET exSim: mineral exploration experience via simulation

    NASA Astrophysics Data System (ADS)

    Wong, Jason C. 13Holden, Eun-Jung 1Kovesi, Peter 1McCuaig, T. Campbell 1Hronsky, Jon

    2013-08-01

    Undercover mineral exploration is a challenging task as it requires understanding of subsurface geology by relying heavily on remotely sensed (i.e. geophysical) data. Cost-effective exploration is essential in order to increase the chance of success using finite budgets. This requires effective decision-making in both the process of selecting the optimum data collection methods and in the process of achieving accuracy during subsequent interpretation. Traditionally, developing the skills, behaviour and practices of exploration decision-making requires many years of experience through working on exploration projects under various geological settings, commodities and levels of available resources. This implies long periods of sub-optimal exploration decision-making, before the necessary experience has been successfully obtained. To address this critical industry issue, our ongoing research focuses on the development of the unique and novel e-learning environment, exSim, which simulates exploration scenarios where users can test their strategies and learn the consequences of their choices. This simulator provides an engaging platform for self-learning and experimentation in exploration decision strategies, providing a means to build experience more effectively. The exSim environment also provides a unique platform on which numerous scenarios and situations (e.g. deposit styles) can be simulated, potentially allowing the user to become virtually familiarised with a broader scope of exploration practices. Harnessing the power of computer simulation, visualisation and an intuitive graphical user interface, the simulator provides a way to assess the user's exploration decisions and subsequent interpretations. In this paper, we present the prototype functionalities in exSim including: simulation of geophysical surveys, follow-up drill testing and interpretation assistive tools.

  17. SIMS: A Hybrid Method for Rapid Conformational Analysis

    PubMed Central

    Gipson, Bryant; Moll, Mark; Kavraki, Lydia E.

    2013-01-01

    Proteins are at the root of many biological functions, often performing complex tasks as the result of large changes in their structure. Describing the exact details of these conformational changes, however, remains a central challenge for computational biology due the enormous computational requirements of the problem. This has engendered the development of a rich variety of useful methods designed to answer specific questions at different levels of spatial, temporal, and energetic resolution. These methods fall largely into two classes: physically accurate, but computationally demanding methods and fast, approximate methods. We introduce here a new hybrid modeling tool, the Structured Intuitive Move Selector (sims), designed to bridge the divide between these two classes, while allowing the benefits of both to be seamlessly integrated into a single framework. This is achieved by applying a modern motion planning algorithm, borrowed from the field of robotics, in tandem with a well-established protein modeling library. sims can combine precise energy calculations with approximate or specialized conformational sampling routines to produce rapid, yet accurate, analysis of the large-scale conformational variability of protein systems. Several key advancements are shown, including the abstract use of generically defined moves (conformational sampling methods) and an expansive probabilistic conformational exploration. We present three example problems that sims is applied to and demonstrate a rapid solution for each. These include the automatic determination of “active” residues for the hinge-based system Cyanovirin-N, exploring conformational changes involving long-range coordinated motion between non-sequential residues in Ribose-Binding Protein, and the rapid discovery of a transient conformational state of Maltose-Binding Protein, previously only determined by Molecular Dynamics. For all cases we provide energetic validations using well-established energy

  18. Training for emergency response with RimSim:Response!

    NASA Astrophysics Data System (ADS)

    Campbell, Bruce D.; Schroder, Konrad A.

    2009-05-01

    Since developing and promoting a Pacific Rim community emergency response simulation software platform called RimSim, the PARVAC team at the University of Washington has developed a variety of first responder agents who can participate within a response simulation. Agents implement response heuristics and communications strategies in conjunction with live players trying to develop their own heuristics and communications strategies to participate in a successful community response crisis. The effort is facilitated by shared visualization of the affected geographical extent. We present initial findings from interacting with a wide variety of mixed agent simulation sessions and make the software available for others to perform their own experiments.e

  19. An AFM-SIMS Nano Tomography Acquisition System

    NASA Astrophysics Data System (ADS)

    Swinford, Richard William

    An instrument, adding the capability to measure 3D volumetric chemical composition, has been constructed by me as a member of the Sanchez Nano Laboratory. The laboratory's in situ atomic force microscope (AFM) and secondary ion mass spectrometry systems (SIMS) are functional and integrated as one instrument. The SIMS utilizes a Ga focused ion beam (FIB) combined with a quadrupole mass analyzer. The AFM is comprised of a 6-axis stage, three coarse axes and three fine. The coarse stage is used for placing the AFM tip anywhere inside a (13x13x5 mm3) (xyz) volume. Thus the tip can be moved in and out of the FIB processing region with ease. The planned range for the Z-axis piezo was 60 microm, but was reduced after it was damaged from arc events. The repaired Z-axis piezo is now operated at a smaller nominal range of 18 microm (16.7 microm after pre-loading), still quite respectable for an AFM. The noise floor of the AFM is approximately 0.4 nm Rq. The voxel size for the combined instrument is targeted at 50 nm or larger. Thus 0.4 nm of xyz uncertainty is acceptable. The instrument has been used for analyzing samples using FIB beam currents of 250 pA and 5.75 nA. Coarse tip approaches can take a long time so an abbreviated technique is employed. Because of the relatively long thro of the Z piezo, the tip can be disengaged by deactivating the servo PID. Once disengaged, it can be moved laterally out of the way of the FIB-SIMS using the coarse stage. This instrument has been used to acquire volumetric data on AlTiC using AFM tip diameters of 18.9 nm and 30.6 nm. Acquisition times are very long, requiring multiple days to acquire a 50-image stack. New features to be added include auto stigmation, auto beam shift, more software automation, etc. Longer term upgrades to include a new lower voltage Z-piezo with strain-gauge feedback and a new design to extend the life for the coarse XY nano-positioners. This AFM-SIMS instrument, as constructed, has proven to be a great proof

  20. SIM PlanetQuest Spectral Calibration Development Unit Beam Combiner

    NASA Technical Reports Server (NTRS)

    Tang, Hong

    2008-01-01

    The beam combiner of an astronomical long-baseline interferometer combines the two beams of starlight to form white-light fringes. We describe beam combiner in the SIM PlanetQuest Spectral Calibration Development Unit (SCDU). In addition to forming white light fringes, the beam combiner provides other functions such as separating the light for guiding, fringe tracking, and science measurement. It is designed to function over the optical bandpass 450-950 nm. Coating design is critical to beam combiner as residual dispersion and mismatches affect the ability to accurately measure the position of stars of varying spectral types.

  1. Summer Institute for Mathematics and Science teachers (SIMS). Final report

    SciTech Connect

    1994-07-01

    The Summer Institute for Mathematics and Science Teachers (SIMS) was to provide training for science and mathematics educators in strategies and techniques to use for educating and motivating historically under-represented populations. The Institute featured 40 hours of training over five days, July 13-17, 1993 plus half-day follow-up training November 13, 1993 and April 30, 1994. The objective of the training was to include sensitization to cultural and gender issues, and to instruct participants in the utilization of a variety of techniques and activities for encouraging historically under-represented groups to take more advanced science and mathematics courses.

  2. The core competencies of James Marion Sims, MD.

    PubMed

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  3. SIM(1)-VSR Maxwell-Chern-Simons electrodynamics

    NASA Astrophysics Data System (ADS)

    Bufalo, R.

    2016-06-01

    In this paper we propose a very special relativity (VSR)-inspired generalization of the Maxwell-Chern-Simons (MCS) electrodynamics. This proposal is based upon the construction of a proper study of the SIM (1)-VSR gauge-symmetry. It is shown that the VSR nonlocal effects present a significant and healthy departure from the usual MCS theory. The classical dynamics is analysed in full detail, by studying the solution for the electric field and static energy for this configuration. Afterwards, the interaction energy between opposite charges is derived and we show that the VSR effects play an important part in obtaining a (novel) finite expression for the static potential.

  4. SimEnvVis: A Climate Data Visualization Wizard

    NASA Astrophysics Data System (ADS)

    Heitzler, Magnus; Nocke, Thomas

    2013-04-01

    To efficiently make sense of complex climate data, climate scientists need to choose and utilize appropriate analysis tools in respect to specific sets of tasks. Among these, visual analysis tools, like those originating from the field of visual analytics, efficiently support to communicate such information by directly addressing human visual perception. However, climate scientists often are not aware of or not familiar with the large variety of available visual analysis tools or are underestimating their potential benefit for common research tasks and thus reducing the probability to use most suitable ones and therefore impairing the knowledge discovery process. To address this problem, SimEnvVis was developed as an easy-to-use wizard-based software system guiding the user step-by-step in choosing most appropriate visualization and visual analytics tools from a large and easily extendable repository consisting of script-based and interactive tools with different application foci (spatial, temporal or abstract data) and supported techniques (e.g. glyphs, isocontours, stream visualization). Considering the analysis context (e.g. data characteristics, user preferences and analysis tasks) SimEnvVis automatically evaluates the attached tools using a combination of a vector-based and a rule-based mechanism. Based on the users decision, the selected visual analysis tool is launched using a template which is dynamically parameterized by taking into account the analysis context. By displaying the session history in different modes as well as providing the possibility to start SimEnvVis in first-time-user mode to reduce GUI complexity and hide tools which are under development the wizard is in particular useful for novice users. This way, SimEnvVis increases the probability for the usage of appropriate visual analysis tools, lowers the obstacles of familiarization with them and therefore accelerates the knowledge discovery process as well as positively contributes to the

  5. Inherited igneous zircons in jadeitite predate high-pressure metamorphism and jadeitite formation in the Jagua Clara serpentinite mélange of the Rio San Juan Complex (Dominican Republic)

    NASA Astrophysics Data System (ADS)

    Hertwig, Andreas; McClelland, William C.; Kitajima, Kouki; Schertl, Hans-Peter; Maresch, Walter V.; Stanek, Klaus; Valley, John W.; Sergeev, Sergey A.

    2016-05-01

    This study utilizes zircon SIMS U-Pb dating, REE and trace-element analysis as well as oxygen isotope ratios of zircon to distinguish jadeite-rich rocks that formed by direct crystallization from a hydrous fluid from those that represent products of a metasomatic replacement process. Zircon was separated from a concordant jadeitite layer and its blueschist host, as well as from loose blocks of albite-jadeite rock and jadeitite that were all collected from the Jagua Clara serpentinite-matrix mélange in the northern Dominican Republic. In the concordant jadeitite layer, three groups of zircon domains were distinguished based on both age as well as geochemical and oxygen isotope values: age groups old (117.1 ± 0.9 Ma), intermediate (three dates: 90.6, 97.3, 106.0 Ma) and young (77.6 ± 1.3 Ma). Zircon populations from the blueschist host as well as the other three jadeite-rich samples generally match zircon domains of the old age group in age as well as geochemistry and oxygen isotope ratios. Moreover, these older zircon populations are indistinguishable from zircon typical of igneous oceanic crust and hence are probably inherited from igneous protoliths of the jadeite-rich rocks. Therefore, the results suggest that all investigated jadeite-rich rocks were formed by a metasomatic replacement process. The younger domains might signal actual ages of jadeitite formation, but there is no unequivocal proof for coeval zircon-jadeite growth.

  6. Structural analysis and shape-preferred orientation determination of the mélange facies in the Chañaral mélange, Las Tórtolas Formation, Coastal Cordillera, northern Chile

    NASA Astrophysics Data System (ADS)

    Fuentes, Paulina; Díaz-Alvarado, Juan; Fernández, Carlos; Díaz-Azpiroz, Manuel; Rodríguez, Natalia

    2016-04-01

    This study sheds light on the tectonic and structural knowledge of the mélange facies located to the south of Chañaral city, Chile. The Chañaral mélange has been related to an accretionary prism at the western active continental margin of Gondwana. Based on the fossil content, the original turbidite sequence would have been deposited during Devonian to Carboniferous times. The Chañaral mélange is included in the Las Tórtolas Formation, which corresponds to the Paleozoic metasedimentary basement located in the Coastal Range in northern Chile. It consists of a monotonous sequence of more than 90% of interbedded sandstones and shales, with a few limestones, pelagic chert, conglomerates and basic volcanic rocks, metamorphosed to the greenschist facies. In the study area, the Las Tórtolas Formation is divided into two structural domains separated by a major reverse dextral structure, called here the Infieles fault. To the east, the Las Tórtolas Formation is characterized by a brittle-ductile deformation, defined by the original sedimentary contacts in the turbiditic sequence. Besides, thrust faults and associated thrust propagation folds promotes a penetrative axial plane foliation. Mélange facies are located to the west of the Infieles fault. Although lithologies comprising this domain are similar to the rest of the Las Tórtolas Formation, mélange facies (ductile domain) are characterized by the complete disruption of the original architecture of the turbidite succession. The most significant structures in the mélange are the ubiquitous boudinage and pinch and swell structures, asymmetric objects, S-C structures and tight to isoclinal folds. This deformation is partitioned in the Chañaral mélange between linear fabric domains (L), characterized by quartzite blocks with prolate shape in a phyllite matrix with pencil structures, and linear-planar fabric domains (L-S), where quartzite objects show oblate shape and phyllites present a penetrative foliation

  7. Elemental and isotopic imaging of biological samples using NanoSIMS.

    PubMed

    Kilburn, Matt R; Clode, Peta L

    2014-01-01

    With its low detection limits and the ability to analyze most of the elements in the periodic table, secondary ion mass spectrometry (SIMS) represents one of the most versatile in situ analytical techniques available, and recent developments have resulted in significant advantages for the use of imaging mass spectrometry in biological and biomedical research. Increases in spatial resolution and sensitivity allow detailed interrogation of samples at relevant scales and chemical concentrations. Advances in dynamic SIMS, specifically with the advent of NanoSIMS, now allow the tracking of stable isotopes within biological systems at subcellular length scales, while static SIMS combines subcellular imaging with molecular identification. In this chapter, we present an introduction to the SIMS technique, with particular reference to NanoSIMS, and discuss its application in biological and biomedical research.

  8. SIMS and NanoSIMS analyses of Mesoproterozoic individual microfossils indicating continuous oxygen-producing photosynthesis in Proterozoic Ocean

    NASA Astrophysics Data System (ADS)

    Peng, X.; Guo, Z.; House, C. H.; Chen, S.; Ta, K.

    2015-12-01

    Well-preserved microfossils in the stromatolites from the Gaoyuzhuang Formation (~1500Ma), which is younger than the Gunflint Formation (~1880Ma) and older than the Bitter Springs Formation (~850Ma), may play key roles in systematizing information about the evolution of early life and environmental changes in the Proterozoic Ocean. Here, a combination of light microscopy (LM), scanning electron microscopy (SEM), focused ion beam (FIB), nano-scale secondary ion mass spectrometry (NanoSIMS) and secondary ion mass spectrometry (SIMS) were employed to characterize the morphology, elemental distributions and carbon isotope values of individual microfossils in the stromatolites from the Gaoyuahzuang Formation. Light microscopy analyses show that abundant filamentous and coccoid microfossils are exceptionally well preserved in chert. NanoSIMS analyses show that metabolically important elements such as 12C-, 13C-, 12C14N-, 32S-, and 34S- are concentrated in these microfossils and that the variations in the concentrations of these elements are similar, establishing the elemental distributions in incontestably biogenic microstructures. Carbon isotope (δ13C) values of individual microfossils range from -32.2‰ ± 0.9‰ to -23.3‰ ± 1.0‰ (weighted mean= -28.9‰ ± 0.1‰), consistent with carbon fixation via the Calvin cycle. The elevated δ13C values of the microfossils from Early-, Meso- to Late Proterozoic Era, possibly indicate decreasing CO2 and increasing O2 concentrations in the Proterozoic atmosphere. Our results, for the first time, provided the element distributions and cell specific carbon isotope values on convincing Mesoproterozoic cyanobacterial fossils, supporting continuous oxygen-producing photosynthesis in the Proterozoic Ocean.

  9. Sim(n-2):Very Special Relativity and its Deformations, Holonomy and Quantum Corrections

    SciTech Connect

    Gibbons, G. W.

    2009-05-01

    I review some recent work on the applications of Sim(n-2), the maximal subroup of the Lorentz group SO(n-1,1). Topics covered include Myrheim's formula for the volume of Aleaxandrov open sets, Lorentz Violation and Very Special Relativity, deformations of Sim(n-2) and Bogoslovky's Finsler model, metrics with holonony Sim(n-2) and the possible absence of quantum corrections.

  10. Review and Analysis of Selected Items Management (SIM) Inventory Program Aboard US Surface Ships

    DTIC Science & Technology

    2005-12-01

    project attempts to assess the impact of this correlation in satisfying the TYCOM’s SIM inventory goals. Additionally, this project examines shipboard...criteria are met. Conversely, SIM items may also be declassified becoming non-SIM items whenever they no longer satisfy the criteria for retention as...requisitions or demands, that are filled or satisfied immediately from shipboard on-hand stock. Figures 1 and 2 below show the computation formula for both

  11. Alternative Liquid Fuels Simulation Model (AltSim).

    SciTech Connect

    Baker, Arnold Barry; Williams, Ryan; Drennen, Thomas E.; Klotz, Richard

    2007-10-01

    The Alternative Liquid Fuels Simulation Model (AltSim) is a high-level dynamic simulation model which calculates and compares the production costs, carbon dioxide emissions, and energy balances of several alternative liquid transportation fuels. These fuels include: corn ethanol, cellulosic ethanol, biodiesel, and diesels derived from natural gas (gas to liquid, or GTL) and coal (coal to liquid, or CTL). AltSim allows for comprehensive sensitivity analyses on capital costs, operation and maintenance costs, renewable and fossil fuel feedstock costs, feedstock conversion efficiency, financial assumptions, tax credits, CO{sub 2} taxes, and plant capacity factor. This paper summarizes the preliminary results from the model. For the base cases, CTL and cellulosic ethanol are the least cost fuel options, at $1.60 and $1.71 per gallon, respectively. Base case assumptions do not include tax or other credits. This compares to a $2.35/gallon production cost of gasoline at September, 2007 crude oil prices ($80.57/barrel). On an energy content basis, the CTL is the low cost alternative, at $12.90/MMBtu, compared to $22.47/MMBtu for cellulosic ethanol. In terms of carbon dioxide emissions, a typical vehicle fueled with cellulosic ethanol will release 0.48 tons CO{sub 2} per year, compared to 13.23 tons per year for coal to liquid.

  12. NanoSIMS and more: New tools in nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Hoppe, P.

    2016-01-01

    Primitive Solar System materials contain nm- to μm-sized presolar grains that formed in the winds of evolved stars and in the ejecta of stellar explosions. These samples of stardust can be analysed in terrestrial laboratories with sophisticated analytical instrumentation in great detail. Of particular importance are coordinated studies of individual grains by Secondary Ion Mass Spectrometry (SIMS), Resonance Ionization Mass Spectrometry (RIMS) and Focused Ion Beam/Transmission Electron Microscopy (FIB/TEM) from which detailed information on isotopic compositions and mineralogies can be obtained. A key tool is the NanoSIMS 50 ion probe which permits to do isotope measurements of light and many intermediate-mass elements with spatial resolutions of <100 nm. A new type of RIMS instrument, “CHILI”, is currently under construction and is aimed to provide <100 nm resolution for isotope studies of intermediate-mass and heavy elements. Another promising analysis technique for future studies is Atom Probe Tomography (APT) which might be useful to create 3D-elemental and isotopic maps of presolar grains at the nanometer scale.

  13. On the SIMS Ionization Probability of Organic Molecules

    NASA Astrophysics Data System (ADS)

    Popczun, Nicholas J.; Breuer, Lars; Wucher, Andreas; Winograd, Nicholas

    2017-06-01

    The prospect of improved secondary ion yields for secondary ion mass spectrometry (SIMS) experiments drives innovation of new primary ion sources, instrumentation, and post-ionization techniques. The largest factor affecting secondary ion efficiency is believed to be the poor ionization probability (α+) of sputtered material, a value rarely measured directly, but estimated to be in some cases as low as 10-5. Our lab has developed a method for the direct determination of α+ in a SIMS experiment using laser post-ionization (LPI) to detect neutral molecular species in the sputtered plume for an organic compound. Here, we apply this method to coronene (C24H12), a polyaromatic hydrocarbon that exhibits strong molecular signal during gas-phase photoionization. A two-dimensional spatial distribution of sputtered neutral molecules is measured and presented. It is shown that the ionization probability of molecular coronene desorbed from a clean film under bombardment with 40 keV C60 cluster projectiles is of the order of 10-3, with some remaining uncertainty arising from laser-induced fragmentation and possible differences in the emission velocity distributions of neutral and ionized molecules. In general, this work establishes a method to estimate the ionization efficiency of molecular species sputtered during a single bombardment event. [Figure not available: see fulltext.

  14. Precision Linear Actuator for Space Interferometry Mission (SIM) Siderostat Pointing

    NASA Technical Reports Server (NTRS)

    Cook, Brant; Braun, David; Hankins, Steve; Koenig, John; Moore, Don

    2008-01-01

    'SIM PlanetQuest will exploit the classical measuring tool of astrometry (interferometry) with unprecedented precision to make dramatic advances in many areas of astronomy and astrophysics'(1). In order to obtain interferometric data two large steerable mirrors, or Siderostats, are used to direct starlight into the interferometer. A gimbaled mechanism actuated by linear actuators is chosen to meet the unprecedented pointing and angle tracking requirements of SIM. A group of JPL engineers designed, built, and tested a linear ballscrew actuator capable of performing submicron incremental steps for 10 years of continuous operation. Precise, zero backlash, closed loop pointing control requirements, lead the team to implement a ballscrew actuator with a direct drive DC motor and a precision piezo brake. Motor control commutation using feedback from a precision linear encoder on the ballscrew output produced an unexpected incremental step size of 20 nm over a range of 120 mm, yielding a dynamic range of 6,000,000:1. The results prove linear nanometer positioning requires no gears, levers, or hydraulic converters. Along the way many lessons have been learned and will subsequently be shared.

  15. Thin film characterization by laser interferometry combined with SIMS

    NASA Astrophysics Data System (ADS)

    Kempf, J.; Nonnenmacher, M.; Wagner, H. H.

    1988-10-01

    Thin film properties of technologically important materials (Si, GaAs, SiO2, WSix) have been measured by using a novel technique that combines secondary ion mass spectrometry (SIMS) and laser interferometry. The simultaneous measurement of optical phase and reflectance as well as SIMS species during ion sputtering yielded optical constants, sputtering rates and composition of thin films with high depth resolution. A model based on the principle of multiple reflection within a multilayer structure, which considered also transformation of the film composition in depth and time during sputtering, was fitted to the reflectance and phase data. This model was applied to reveal the transformation of silicon by sputtering with O{2/+} ions. Special attention was paid to the preequilibrium phase of the sputter process (amorphization, oxidation, and volume expansion). To demonstrate the analytical potential of our method the multilayer system WSix/poly-Si/SiO2/Si was investigated. The physical parameters and the stoichiometry of tungsten suicide were determined for annealed as well as deposited films. A highly sensitive technique that makes use of a Fabry-Perot etalon integrated with a Michelson type interferometer is proposed. This two-stage interferometer has the potential to profile a sample surface with subangstroem resolution.

  16. The SIM Lite Astrometric Observatory: engineering risk reduction activity

    NASA Astrophysics Data System (ADS)

    Goullioud, Renaud; Dekens, Frank; Nemati, Bijan; An, Xin; Hovland, Larry

    2010-07-01

    The SIM Lite Astrometric Observatory is a mission concept for a space-borne instrument to perform micro-arcsecond narrow-angle astrometry to search 60 to 100 nearby stars for Earth-like planets, and to perform global astrometry for a broad astrophysics program. The main enabling technology development for the mission was completed during phases A & B. While the project is waiting for the results of the ASTRO2010 Decadal Survey to proceed into flight implementation, the instrument team is currently converting the developed technology onto flight-ready engineering models. These key engineering tasks will significantly reduce the implementation risks during the flight phases C & D of the mission. The main optical interferometer components, including the astrometric beam combiner (ABC), the fine steering mechanism (FSM), the path-length control and modulation optical mechanisms (POM & MOM), focal plane camera electronics (ATC & FTC), camera cooling cryo-heat pipe, and the siderostat mechanism are currently under development. Main assemblies are built to meet flight requirements and have been or will be subjected to flight qualification level environmental testing (random vibration and thermal cycling) and performance testing. The Spectral Calibration Development Unit (SCDU), a white light interferometer testbed has recently demonstrated how to perform the spectral calibration of the instrument. The Guide 2 Telescope testbed (G2T) has demonstrated the 50 micro-arcsecond angle monitoring capability required by SIM Lite to perform astrometry. This paper summarizes recent progress in engineering risk reduction activities.

  17. On the SIMS Ionization Probability of Organic Molecules

    NASA Astrophysics Data System (ADS)

    Popczun, Nicholas J.; Breuer, Lars; Wucher, Andreas; Winograd, Nicholas

    2017-03-01

    The prospect of improved secondary ion yields for secondary ion mass spectrometry (SIMS) experiments drives innovation of new primary ion sources, instrumentation, and post-ionization techniques. The largest factor affecting secondary ion efficiency is believed to be the poor ionization probability (α+) of sputtered material, a value rarely measured directly, but estimated to be in some cases as low as 10-5. Our lab has developed a method for the direct determination of α+ in a SIMS experiment using laser post-ionization (LPI) to detect neutral molecular species in the sputtered plume for an organic compound. Here, we apply this method to coronene (C24H12), a polyaromatic hydrocarbon that exhibits strong molecular signal during gas-phase photoionization. A two-dimensional spatial distribution of sputtered neutral molecules is measured and presented. It is shown that the ionization probability of molecular coronene desorbed from a clean film under bombardment with 40 keV C60 cluster projectiles is of the order of 10-3, with some remaining uncertainty arising from laser-induced fragmentation and possible differences in the emission velocity distributions of neutral and ionized molecules. In general, this work establishes a method to estimate the ionization efficiency of molecular species sputtered during a single bombardment event.

  18. Purchase and Installation of NanoSIMS 50

    NASA Technical Reports Server (NTRS)

    Walker, Robert M.

    2001-01-01

    Although this is a final report on NASA grant number NAG5-8729 we wish to state at the outset that it was mistakenly written as a two-year grant instead of a three-year grant as should have been done. The grant was made for the purpose of purchasing and installing a novel ion microprobe initially called the NanoSIMS 50 and now called the NanoSIMS. The total cost to NASA for purchasing the instrument and refurbishing a laboratory to house it was $1.1 M, split into three installments of $400 (FY 1999), $350K (FY2000), and $350K (FY-2001). We received the first installment in full and $335K in FY2000 for the second installment. The final $350K necessary to complete the purchase and installation was expected by us in the spring of 2001. However, we were recently informed that no more money can be transferred on this grant since it was originally written as a two-year grant. Therefore, we are closing out the current grant and simultaneously writing a new proposal to obtain the final $350K needed to complete the purchase.

  19. Analysis of Nickel Silicides by SIMS and LEAP

    SciTech Connect

    Ronsheim, Paul; McMurray, Jeff; Flaitz, Philip; Parks, Christopher

    2007-09-26

    Ni-silicides formed by a variety of processing techniques were studied with secondary ion mass spectroscopy (SIMS) and local electrode atom probe (LEAP registered ) analysis. SIMS provided 1-D chemical analysis over an approximately 60 micron diameter area. LEAP provided 3-D atom identities and locations over an approximately 100-150 nm diameter area. It was determined that the 200 deg. C drive-in anneal results in a Ni{sub 3}Si{sub 2} phase, which is converted to NiSi at temperatures between 360 deg. C-400 deg. C. LEAP detects no As or Pt segregation after the 200 deg. C drive-in anneal, but did quantify As segregation of up to 7% of the material composition just inside the NiSi-Si interface after the phase-formation anneal. The presence of oxygen at the interface results in a silicide chemical surface roughness of up to 3.5 nm as compared to 0.5 nm with a clean, non-oxidized surface. Silicide stability was demonstrated over the phase-formation-temperature range of 360 deg. C - 400 deg. C including when a second rapid thermal anneal step was used. LEAP analysis was also able to quantify the surface roughness of the interface as a function of anneal temperature and the non-uniform Pt and As distribution across the silicide surface as viewed in 2-D surface projection.

  20. On the SIMS Ionization Probability of Organic Molecules.

    PubMed

    Popczun, Nicholas J; Breuer, Lars; Wucher, Andreas; Winograd, Nicholas

    2017-03-06

    The prospect of improved secondary ion yields for secondary ion mass spectrometry (SIMS) experiments drives innovation of new primary ion sources, instrumentation, and post-ionization techniques. The largest factor affecting secondary ion efficiency is believed to be the poor ionization probability (α(+)) of sputtered material, a value rarely measured directly, but estimated to be in some cases as low as 10(-5). Our lab has developed a method for the direct determination of α(+) in a SIMS experiment using laser post-ionization (LPI) to detect neutral molecular species in the sputtered plume for an organic compound. Here, we apply this method to coronene (C24H12), a polyaromatic hydrocarbon that exhibits strong molecular signal during gas-phase photoionization. A two-dimensional spatial distribution of sputtered neutral molecules is measured and presented. It is shown that the ionization probability of molecular coronene desorbed from a clean film under bombardment with 40 keV C60 cluster projectiles is of the order of 10(-3), with some remaining uncertainty arising from laser-induced fragmentation and possible differences in the emission velocity distributions of neutral and ionized molecules. In general, this work establishes a method to estimate the ionization efficiency of molecular species sputtered during a single bombardment event. Graphical Abstract .

  1. Simultaneous Analysis of the Behavioural Phenotype, Physical Factors, and Parenting Stress in People with Cornelia De Lange Syndrome

    ERIC Educational Resources Information Center

    Wulffaert, J.; van Berckelaer-Onnes, I.; Kroonenberg, P.; Scholte, E.; Bhuiyan, Z.; Hennekam, R.

    2009-01-01

    Background: Studies into the phenotype of rare genetic syndromes largely rely on bivariate analysis. The aim of this study was to describe the phenotype of Cornelia de Lange syndrome (CdLS) in depth by examining a large number of variables with varying measurement levels. Virtually the only suitable multivariate technique for this is categorical…

  2. Social Behavior and Characteristics of Autism Spectrum Disorder in Angelman, Cornelia de Lange, and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna; Howlin, Patricia; Hastings, Richard Patrick; Beaumont, Sarah; Griffith, Gemma M.; Petty, Jane; Tunnicliffe, Penny; Yates, Rachel; Villa, Darrelle; Oliver, Chris

    2013-01-01

    We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; "n" ?=? 19; mean age ?=?10.35 years), Cornelia de Lange (CdLS; "n" ?=? 15; mean age ?=?12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; "n" ?=? 19; mean age ?=? 8.80 years) syndromes. The proportion of…

  3. A Longitudinal Follow-Up Study of Affect in Children and Adults with Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Nelson, Lisa; Moss, Jo; Oliver, Chris

    2014-01-01

    Studies of individuals with Cornelia de Lange syndrome (CdLS) have described changes in mood and behavior with age, although no empirical or longitudinal studies have been conducted. Caregivers of individuals with CdLS (N = 67), cri du chat syndrome (CdCS; N = 42), and Fragile X syndrome (FXS; N = 142) completed the Mood, Interest and Pleasure…

  4. Effects of Social Context on Social Interaction and Self-Injurious Behavior in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Arron, Kate; Oliver, Chris; Hall, Scott; Sloneem, Jenny; Forman, Debbie; McClintock, Karen

    2006-01-01

    Cornelia de Lange syndrome is reported to be associated with self-injurious behavior (SIB) and social avoidance. We used analog methodology to examine the effect of manipulating adult social contact on social communicative behaviors and SIB in 16 children with this syndrome. For 9 participants engagement behavior was related to levels of adult…

  5. A Longitudinal Follow-Up Study of Affect in Children and Adults with Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Nelson, Lisa; Moss, Jo; Oliver, Chris

    2014-01-01

    Studies of individuals with Cornelia de Lange syndrome (CdLS) have described changes in mood and behavior with age, although no empirical or longitudinal studies have been conducted. Caregivers of individuals with CdLS (N = 67), cri du chat syndrome (CdCS; N = 42), and Fragile X syndrome (FXS; N = 142) completed the Mood, Interest and Pleasure…

  6. Social Behavior and Characteristics of Autism Spectrum Disorder in Angelman, Cornelia de Lange, and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna; Howlin, Patricia; Hastings, Richard Patrick; Beaumont, Sarah; Griffith, Gemma M.; Petty, Jane; Tunnicliffe, Penny; Yates, Rachel; Villa, Darrelle; Oliver, Chris

    2013-01-01

    We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; "n" ?=? 19; mean age ?=?10.35 years), Cornelia de Lange (CdLS; "n" ?=? 15; mean age ?=?12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; "n" ?=? 19; mean age ?=? 8.80 years) syndromes. The proportion of…

  7. High temporal and spatial resolution inverse modeling of mélange rheology at Helheim Glacier, southeast Greenland

    NASA Astrophysics Data System (ADS)

    James, T.; Borstad, C. P.; Drocourt, Y. J. R.; Murray, T.

    2015-12-01

    The calving of icebergs is responsible for a significant proportion of annual mass loss from marine-terminating glaciers and is believed to be a major factor in the rapid demise of paleo-ice sheets. Iceberg calving indirectly influences buttressing against the ice flow by controlling the structure and extent of ice mélange. This mixture of icebergs and seasonal sea ice that forms at the ice-ocean interface of many fast flowing outlet glaciers is believed to have an important influence on the flow of outlet glaciers. However, its physical properties are not well understood and there is disagreement about how to represent it in models. With recent forecasts anticipating that the majority of mass loss from the Greenland Ice Sheet will be dynamic in origin over the next two centuries, improving understanding of the mélange is key. We applied stereo digital photogrammetric methods to a high temporal and spatial resolution time series of time-lapse imagery to generate velocity fields and elevation models of the terminal region and ice mélange of Helheim glacier in Greenland's southeast. For the first time, we use an inverse method implemented in an ice sheet model to determine the spatial pattern of mélange rheology that is consistent with the velocity fields. We explore the variation of the rheology pattern through time to identify areas that support higher stresses and thus provide greater buttressing.

  8. Effects of Social Context on Social Interaction and Self-Injurious Behavior in Cornelia de Lange Syndrome

    ERIC Educational Resources Information Center

    Arron, Kate; Oliver, Chris; Hall, Scott; Sloneem, Jenny; Forman, Debbie; McClintock, Karen

    2006-01-01

    Cornelia de Lange syndrome is reported to be associated with self-injurious behavior (SIB) and social avoidance. We used analog methodology to examine the effect of manipulating adult social contact on social communicative behaviors and SIB in 16 children with this syndrome. For 9 participants engagement behavior was related to levels of adult…

  9. Simultaneous Analysis of the Behavioural Phenotype, Physical Factors, and Parenting Stress in People with Cornelia De Lange Syndrome

    ERIC Educational Resources Information Center

    Wulffaert, J.; van Berckelaer-Onnes, I.; Kroonenberg, P.; Scholte, E.; Bhuiyan, Z.; Hennekam, R.

    2009-01-01

    Background: Studies into the phenotype of rare genetic syndromes largely rely on bivariate analysis. The aim of this study was to describe the phenotype of Cornelia de Lange syndrome (CdLS) in depth by examining a large number of variables with varying measurement levels. Virtually the only suitable multivariate technique for this is categorical…

  10. A SIMS Calibration of Benthic Foraminiferal Mg/Ca

    NASA Astrophysics Data System (ADS)

    Curry, W. B.; Marchitto, T. M.

    2005-12-01

    Using a suite of multi-core tops, we have produced a calibration of C. pachyderma Mg/Ca versus temperature spanning the temperature range of 5 to 18 °C. The core tops are located along the Florida margin south of Dry Tortugas (KNR166), along the Bahamas west of Andros Island and Great Bahama Bank (KNR166), and along the southeastern margin of Brazil (KNR159). Water depths range from about 200 to 800 m for the Florida Straits multi-cores and 400 to 800 m for the Brazil margin multi-cores. Five of the KNR166 core tops contain post-1950 bomb radiocarbon with Fmodern> 1; several others have bomb radiocarbon mixed in with pre-bomb sediments to give ages less than 0 BP. Core top ages are generally older for the KNR159 multi-cores, but each is from a location with a well documented Holocene section. Sedimentation rates for KNR166 multi-cores vary from 10 to 100 cm kyr-1; for KNR159 multi-cores, sedimentation rates vary from 5 to 10 cm kyr-1. Elemental ratios were determined by Secondary Ionization Mass Spectrometry (SIMS) using a Cameca IMS 3f ion probe calibrated for Mg/Ca and Sr/Ca using two standards which were independently measured using ICP-MS. Using SIMS, the external precision of the calibration standards averages ±3.5% (1σ RSD) for Mg/Ca and ± 1.7% (1σ RSD) for Sr/Ca. SIMS elemental measurements were performed on one to three individual C. pachyderma tests in each core top; more than 30 tests have been measured from 18 multi-core tops. Mg/Ca variability within C. pachyderma tests averages ± 20% (1σ RSD) with a small but significant trend toward higher variability at higher Mg/Ca. Higher Mg/Ca is observed in warmer waters, but the Mg/Ca values are generally lower (at comparable warm temperatures) than observed in previous calibration studies. At temperatures below 8 °C, C. pachyderma Mg/Ca values are less than 2 mmole/mole. At temperatures warmer than 15 °C, C. pachyderma Mg/Ca values exceed 3 mmole/mole. The slope of Mg/Ca versus temperature (~0.14 mmole

  11. Chemical Imaging of the Cell Membrane by NanoSIMS

    SciTech Connect

    Weber, P K; Kraft, M L; Frisz, J F; Carpenter, K J; Hutcheon, I D

    2010-02-23

    The existence of lipid microdomains and their role in cell membrane organization are currently topics of great interest and controversy. The cell membrane is composed of a lipid bilayer with embedded proteins that can flow along the two-dimensional surface defined by the membrane. Microdomains, known as lipid rafts, are believed to play a central role in organizing this fluid system, enabling the cell membrane to carry out essential cellular processes, including protein recruitment and signal transduction. Lipid rafts are also implicated in cell invasion by pathogens, as in the case of the HIV. Therefore, understanding the role of lipid rafts in cell membrane organization not only has broad scientific implications, but also has practical implications for medical therapies. One of the major limitations on lipid organization research has been the inability to directly analyze lipid composition without introducing artifacts and at the relevant length-scales of tens to hundreds of nanometers. Fluorescence microscopy is widely used due to its sensitivity and specificity to the labeled species, but only the labeled components can be observed, fluorophores can alter the behavior of the lipids they label, and the length scales relevant to imaging cell membrane domains are between that probed by fluorescence resonance energy transfer (FRET) imaging (<10 nm) and the diffraction limit of light. Topographical features can be imaged on this length scale by atomic force microscopy (AFM), but the chemical composition of the observed structures cannot be determined. Immuno-labeling can be used to study the distribution of membrane proteins at high resolution, but not lipid composition. We are using imaging mass spectrometry by secondary ion mass spectrometry (SIMS) in concert with other high resolution imaging methods to overcome these limitations. The experimental approach of this project is to combine molecule-specific stable isotope labeling with high-resolution SIMS using a

  12. A new application of SAM in the non-destructive inspection for SIM card

    NASA Astrophysics Data System (ADS)

    Cai, Bin; He, Yandong; Zhao, Yang; Chen, Yanning; Zhang, Haifeng; Zhao, Dongyan

    2017-07-01

    Scanning Acoustic Microscopy (SAM) is a typical inspection method in the semiconductor IC manufacturing industry. Because the die thickness is a key parameter for SIM card, a new method to measure the internal die thickness of SIM card is proposed with SAM’s reflective scanning mode. Using this method the internal die thickness of SIM card can be accurately measured without introducing any damages to SIM card. The thickness model and methodology based on the SAM signals have been established. The model was properly verified and calibrated by two real test cases.

  13. [The modifed Eden-Lange procedure for paralysis of the trapezius muscle].

    PubMed

    Ozalp, Taçkin; Yercan, Hüseyin; Okçu, Güvenir; Erkan, Serkan

    2007-01-01

    Trapezius muscle paralysis results from injury to the spinal accessory nerve. Impairment in the trapezius muscle function may destabilize the muscle resulting in winged scapula. A 25-year-old university student who was active in sports had complaints of shoulder drop and pain on abduction. He had a three-year history of fall resulting in a scapular fracture for which he received conservative treatment. Physical examination showed asymmetry and drop of the right shoulder. Lateral scapular winging was apparent particularly above 90 degrees of abduction. Electromyography revealed isolated paralysis of the trapezius muscle. The patient underwent reconstruction with the modified Eden-Lange procedure. After a two-year follow-up, asymmetry in the shoulder decreased, there was no pain on active abduction, and the patient returned to active sports and was fully satisfied with the outcome.

  14. Identical twin discordance for the Brachmann-de Lange syndrome revisited

    SciTech Connect

    Carakushansky, G.; Goncalves, M.R.; Kahn, E.

    1996-06-14

    The only known twin pair evidently discordantly affected for the BDLS (Brachmann-de Lange syndrome) and who had been considered monozygotic (MZ) based on blood analysis remained a problem because biological zygosity determination needed further typing. In this report we review the clinical findings of this pair of twins at the age of 20. The use of DNA fingerprinting with three multilocus probes, F10, DNT24, and 33.6, allowed us to present evidence of monozygosity with a high degree of certainty. The significance of this confirmation of discordance in determining the cause of BDLS is discussed. Intensive comparative genomic studies of the discordant twin sisters may be useful to unravel the molecular genetics of this enigmatic pattern of malformation. 21 refs., 2 figs.

  15. Context-induced paranormal experiences: support for Houran and Lange's model of haunting phenomena.

    PubMed

    Lange, R; Houran, J

    1997-06-01

    Houran and Lange's psychological model of haunting phenomena predicts that contextual variables alone are sufficient to induce poltergeist-like perceptions. 22 subjects individually visited five areas of a performance theater and were asked to notice the environment. 11 subjects in an informed condition were instructed that the location was haunted, while 11 in the control condition were told that the building was simply under renovation. Subjects' perceptions in both conditions were recorded via Green, et al.'s 1992 experiential questionnaire which contains 10 subscales related to psychological and physiological perceptions. Analysis yielded significantly more intense perceptual experiences on nine of the ten subscales in the informed condition, indicating that demand characteristics alone can stimulate paranormal-type experiences.

  16. The Drosophila melanogaster Model for Cornelia de Lange Syndrome: Implications for Etiology and Therapeutics

    PubMed Central

    Dorsett, Dale

    2016-01-01

    Discovery of genetic alterations that cause human birth defects provide key opportunities to improve the diagnosis, treatment, and family counseling. Frequently, however, these opportunities are limited by the lack of knowledge about the normal functions of the affected genes. In many cases, there is more information about the gene’s orthologs in model organisms, including Drosophila melanogaster. Despite almost a billion years of evolutionary divergence, over three-quarters of genes linked to human diseases have Drosophila homologs. With a short generation time, a twenty-fold smaller genome, and unique genetic tools, the conserved functions of genes are often more easily elucidated in Drosophila than in other organisms. Here we present how this applies to Cornelia de Lange syndrome, as a model for how Drosophila can be used to increase understanding of genetic syndromes caused by mutations with broad effects on gene transcription and exploited to develop novel therapies. PMID:27097273

  17. The Drosophila melanogaster model for Cornelia de Lange syndrome: Implications for etiology and therapeutics.

    PubMed

    Dorsett, Dale

    2016-06-01

    Discovery of genetic alterations that cause human birth defects provide key opportunities to improve the diagnosis, treatment, and family counseling. Frequently, however, these opportunities are limited by the lack of knowledge about the normal functions of the affected genes. In many cases, there is more information about the gene's orthologs in model organisms, including Drosophila melanogaster. Despite almost a billion years of evolutionary divergence, over three-quarters of genes linked to human diseases have Drosophila homologs. With a short generation time, a twenty-fold smaller genome, and unique genetic tools, the conserved functions of genes are often more easily elucidated in Drosophila than in other organisms. Here we present how this applies to Cornelia de Lange syndrome, as a model for how Drosophila can be used to increase understanding of genetic syndromes caused by mutations with broad effects on gene transcription and exploited to develop novel therapies. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. A Case Report of Cornelia De Lange Syndrome in Northern Iran; A Clinical and Diagnostic Study.

    PubMed

    Hosseininejad, Seyyed-Mohsen; Bazrafshan, Behnaz; Alaee, Ehsan

    2016-02-01

    As a rare multisystem congenital anomaly disorder, Cornelia de Lange syndrome (CdLS) is featured by delayed growth and development, distinct facial dimorphism, limb malformations and multiple organ defects. CdLS is a genetic syndrome affecting 1/10000-1/60000 neonates with unknown genetic basis. Delayed growth and development, hirsute, structural anomalies of the limbs and distinct facial dimorphism are considered as its main clinical characteristics. Introducing CdLS cases of different ethnic backgrounds could add distinctions to the phenotypic picture of the syndrome and be useful in diagnosis. Early diagnosis and decreased death rates are achievable through enhanced awareness on this syndrome. We present here a 45-day-old girl, as the first case of Cornelia in Golestan (Northern Iran), referred to our hospital with the symptoms as mentioned above.

  19. Cornelia de Lange syndrome due to mosaic NIPBL mutation: antenatal presentation with sacrococcygeal teratoma.

    PubMed

    Banait, Nishant; Fenton, Alan; Splitt, Miranda

    2015-08-14

    A male infant at 36 weeks gestation was born by section. At 20 weeks of gestation, congenital diaphragmatic hernia and sacrococcygeal teratoma had been seen on ultrasound. At birth, the infant had features suggestive of Cornelia de Lange syndrome (CdLS). He remained hypoxic despite aggressive ventilatory manoeuvres and was palliated. At postmortem, the lungs were hypoplastic. In CdLS, mutations in NIPBL are found in around 50% of cases. Mutation analysis, including multiplex ligation dependent probe amplification of the NIPBL gene from the DNA extracted from peripheral blood lymphocytes was negative, but microarray comparative genomic hybridisation on DNA from skin fibroblast showed a 0.13Mb deletion on chromosome 5p13. The deleted region includes exons 42-47 of the NIPBL gene. It is important to perform NIBPL mutation analysis on DNA from more than one tissue when testing for CdLS. 2015 BMJ Publishing Group Ltd.

  20. Pharmacological treatment of aggressive behavior and emesis in the Cornelia de Lange Syndrome.

    PubMed

    Andrasik, F; Ollendick, T H; Turner, S M; Hughes, J R

    1979-12-01

    Chlorpromazine and fluphenazine decanoate were employed to treat aggressive behavior and emesis in a 22-year-old patient with Cornelia de Lange syndrome. Institution of the above neuroleptics, following an unsuccessful trial of diazepam, produced reductions of 95.1 per cent and 37.9 per cent for aggressive behavior and emesis, respectively. Four follow-up observations, occurring at 3-week intervals, revealed maintenance of low rates of aggressive behavior and continued reductions in emesis (mean reduction of 81.5 per cent). These findings are important for their a) inclusion of direct behavioral observation as the data base, and b) initial promising effects of neuroleptics for a rare mental retardation syndrome.

  1. Geochemical evidence for mélange melting in global arcs.

    PubMed

    Nielsen, Sune G; Marschall, Horst R

    2017-04-01

    In subduction zones, sediments and hydrothermally altered oceanic crust, which together form part of the subducting slab, contribute to the chemical composition of lavas erupted at the surface to form volcanic arcs. Transport of this material from the slab to the overlying mantle wedge is thought to involve discreet melts and fluids that are released from various portions of the slab. We use a meta-analysis of geochemical data from eight globally representative arcs to show that melts and fluids from individual slab components cannot be responsible for the formation of arc lavas. Instead, the data are compatible with models that first invoke physical mixing of slab components and the mantle wedge, widely referred to as high-pressure mélange, before arc magmas are generated.

  2. Irvin Yalom's Experiment Revisited: Applying Robert Langs's Listening Process to a Psychotherapy Classic.

    PubMed

    Russell, Richard L

    2017-06-01

    In a case now famous for its unconventionality, Irvin Yalom had his financially strapped patient submit written reports of the experience of her therapy sessions rather than pay a monetary fee. He also wrote reports of each session, and the two of them shared royalties from the book, Every Day Gets a Little Closer, eventually produced. The arrangement yielded enough process detail to warrant examination through Robert Langs's method of listening and formulating. From that perspective, it seems Yalom did not understand the encoded messages from his patient in reaction to the frame deviations, which resulted in a deterioration of the communicative field and treatment alliance. Yalom did help his patient to become more appropriately assertive, but her inner fragmentation was untouched.

  3. William W. Lang's contributions to the development of the International Institute of Noise Control Engineering

    NASA Astrophysics Data System (ADS)

    Kihlman, Tor

    2005-09-01

    Bill Lang has been a member of the Board of I-INCE since its first meeting in 1975 in Sendai, Japan. From 1988 to 1999 he served as the President, and to this day remains a very active member of the Board. The INTER-NOISE congress series has been the core activity of I-INCE, and in every case Bill has contributed very actively to secure an excellent congress. He has also taken a number of initiatives both to improve the organization itself and to develop new activities, especially the Technical Study Groups that have prepared consensus reports on important issues such as noise barrier effectiveness and industrial noise hearing conservation policy. At present, he is very active in attempting to develop a global noise control policy.

  4. High-grade metamafic blocks in Franciscan mélanges--olistostromal and/or tectonic?

    NASA Astrophysics Data System (ADS)

    Ernst, W. G.

    2013-12-01

    At ~175 Ma, onset of transpressive plate underflow generated an Andean-type arc along the Californian margin. The east-descending oceanic crust was metamorphosed to eclogite, garnet-blueschist, and amphibolite facies high-pressure (HP) assemblages in an inboard subduction zone at ~165-150 Ma. Except for the fragmentary Red Ant blueschists that crop out in the northern Sierran Foothills, most such metamafic rocks apparently were stored in a low-T environment well into mid- and Late Cretaceous time. Many of the high-grade metamafic rocks returned surfaceward transported as HP tectonic blocks in buoyant Franciscan serpentinite or in subducting, circulating, low-density mud-matrix mélange. However, the rare occurrence of high-grade clasts in relatively feebly recrystallized Franciscan metaconglomerates reflects a sedimentary (including olistostromal) deposition for some HP metamafic blocks. Actinolitic rinds partially encircle many high-grade blocks of either tectonic or olistostromal putative origin. These rinds are only very slightly younger than the subduction-zone metamorphism, suggesting that an early stage of metasomatic exchange took place between HP metabasalt and serpentinized harzburgite along the dynamic oceanic crust-mantle hanging-wall junction, probably while the metamafic rocks were sequestered at moderately shallow mantle depths. For HP metabasaltic rocks to have been added to the Cretaceous Franciscan clastic section as olistoliths, they must first have been carried surfaceward as tectonic blocks immersed in a low-density lithology--probably serpentinite diapirs--then eroded and transported into the trench. Whatever their origin, due to widespread post-depositional convergent-margin shearing, the original natures of many such HP metamafic blocks have been obliterated. In any case, these dense, high-grade rocks of latest Jurassic recrystallization age must have been supplied to the Cretaceous Franciscan accretionary prism by a stage of entrainment in a

  5. Improvement in hearing loss over time in Cornelia de Lange syndrome.

    PubMed

    Janek, Kevin C; Smith, David F; Kline, Antonie D; Benke, James R; Chen, Mei-Ling; Kimball, Amy; Ishman, Stacey L

    2016-08-01

    Patients with Cornelia de Lange Syndrome (CdLS) are reported to have conductive (CHL) and sensorineural hearing loss (SNHL), but there is little information pertaining to the progression of hearing loss over time. The goal of this study was to examine the prevalence of CHL and SNHL in adults and children with CdLS and look for changes in SNHL over time. Retrospective chart review of patients with CdLS presenting to a CdLS clinic was conducted. Also, a written survey of clinical concerns was collected from additional patients/families seen in the clinic and through the Cornelia de Lange Foundation. Seventy-eight patients (50% female) were included in the chart review. Mean age was 16.8 ± 11.4 years (range-0.6-50 years) and mean age at diagnosis of hearing loss was 4.6 ± 10.6 years (n = 26). Five patients (6.4%) had severe to profound SNHL that improved with time, including 2 who had complete normalization of audiogram results. Thirty-five families/patients completed the clinical survey, and 45.5% of the families reported a noticeable improvement of hearing over time. Conductive hearing loss and SNHL are common in CdLS. More than 50% of the patients seen in an adult CdLS clinic reported improvement in hearing loss over time, and a subset of patients had an improvement in SNHL. In light of these findings, we recommend longitudinal evaluations of hearing loss in these patients with both auditory brainstem response and otoacoustic emissions testing if SNHL is identified. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Cornelia de Lange syndrome - characteristics and laparoscopic treatment modalities of reflux based on own material.

    PubMed

    Szyca, Robert; Leksowski, Krzysztof

    2011-09-01

    Cornelia de Lange syndrome (typus degenerativus amstelodamensis, CdLS, Brachmann syndrome) is a complex, congenital, multi-gene anomaly characterized by mental retardation. Its features include growth inhibition, hirsutism, structural anomalies of the limbs and abnormal development of osseous structures of the face. Independent of the phenotype of the disease, 85% of patients are assumed to have symptoms of gastroesophageal reflux disease (GERD). Aspiration pneumonia is one of the complications of GERD and a main cause of death in these patients. Patients not responding to medical treatment qualify for surgery. Until recently, anti-reflux procedures for GERD in CdLS patients were performed solely via laparotomy. The contemporary gold standard is a procedure performed laparoscopically. There are a few case reports of patients with CdLS operated on for GERD with laparoscopy available in the literature. The goal of this paper is to present two cases of Cornelia de Lange syndrome treated with laparoscopic antireflux procedures. We have performed two such procedures in 14 and 16 year-old girls with typical symptoms of the syndrome, i.e. developmental and mental retardation, hirsutism, structural limb anomalies and abnormal face development. The main indications for surgery in both cases were ineffective medical treatment and persistent aspiration pneumonia and its complications as a result of the gastroesophageal reflux. Oesophageal hiatus hernia and reflux were confirmed with accessory tests in both cases. During 36 months of follow-up, according to Barents, no episode of oesophageal reflux with acidic gastric content was noted. The treated children slept well during the night and did not need hospitalization for aspiration pneumonia. Neither of them required proton pump inhibitors. It should be concluded that laparoscopic Nissen fundoplication is a safe and effective method of GERD treatment in children with CdLS.

  7. Construct validity of the LapSim: can the LapSim virtual reality simulator distinguish between novices and experts?

    PubMed

    van Dongen, K W; Tournoij, E; van der Zee, D C; Schijven, M P; Broeders, I A M J

    2007-08-01

    Virtual reality simulators may be invaluable in training and assessing future endoscopic surgeons. The purpose of this study was to investigate if the results of a training session reflect the actual skill of the trainee who is being assessed and thereby establish construct validity for the LapSim virtual reality simulator (Surgical Science Ltd., Gothenburg, Sweden). Forty-eight subjects were assigned to one of three groups: 16 novices (0 endoscopic procedures), 16 surgical residents in training (>10 but <100 endoscopic procedures), and 16 experienced endoscopic surgeons (>100 endoscopic procedures). Performance was measured by a relative scoring system that combines single parameters measured by the computer. The higher the level of endoscopic experience of a participant, the higher the score. Experienced surgeons and surgical residents in training showed statistically significant higher scores than novices for both overall score and efficiency, speed, and precision parameters. Our results show that performance of the various tasks on the simulator corresponds to the respective level of endoscopic experience in our research population. This study demonstrates construct validity for the LapSim virtual reality simulator. It thus measures relevant skills and can be integrated in an endoscopic training and assessment program.

  8. The Hydrogen Futures Simulation Model (H[2]Sim) technical description.

    SciTech Connect

    Jones, Scott A.; Kamery, William; Baker, Arnold Barry; Drennen, Thomas E.; Lutz, Andrew E.; Rosthal, Jennifer Elizabeth

    2004-10-01

    Hydrogen has the potential to become an integral part of our energy transportation and heat and power sectors in the coming decades and offers a possible solution to many of the problems associated with a heavy reliance on oil and other fossil fuels. The Hydrogen Futures Simulation Model (H2Sim) was developed to provide a high level, internally consistent, strategic tool for evaluating the economic and environmental trade offs of alternative hydrogen production, storage, transport and end use options in the year 2020. Based on the model's default assumptions, estimated hydrogen production costs range from 0.68 $/kg for coal gasification to as high as 5.64 $/kg for centralized electrolysis using solar PV. Coal gasification remains the least cost option if carbon capture and sequestration costs ($0.16/kg) are added. This result is fairly robust; for example, assumed coal prices would have to more than triple or the assumed capital cost would have to increase by more than 2.5 times for natural gas reformation to become the cheaper option. Alternatively, assumed natural gas prices would have to fall below $2/MBtu to compete with coal gasification. The electrolysis results are highly sensitive to electricity costs, but electrolysis only becomes cost competitive with other options when electricity drops below 1 cent/kWhr. Delivered 2020 hydrogen costs are likely to be double the estimated production costs due to the inherent difficulties associated with storing, transporting, and dispensing hydrogen due to its low volumetric density. H2Sim estimates distribution costs ranging from 1.37 $/kg (low distance, low production) to 3.23 $/kg (long distance, high production volumes, carbon sequestration). Distributed hydrogen production options, such as on site natural gas, would avoid some of these costs. H2Sim compares the expected 2020 per mile driving costs (fuel, capital, maintenance, license, and registration) of current technology internal combustion engine (ICE) vehicles

  9. A comparative study on detection of organic surface modifiers on mineral grains by TOF-SIMS, VUV SALI TOF-SIMS and VUV SALI with laser desorption

    NASA Astrophysics Data System (ADS)

    Dimov, S. S.; Chryssoulis, S. L.

    2004-06-01

    Results from a comparative study on the detection of organic collectors by TOF-SIMS, vacuum ultraviolet surface analysis by laser ionization with TOF-SIMS detection (VUV SALI TOF-SIMS) and VUV SALI with laser desorption (VUV TOF-LIMS) are reported. The study was carried out on a PHI 7200 TOF-SIMS instrument upgraded with two lasers: one for laser desorption and another one for VUV laser postionization. A systematic analysis of the laser desorption process lead to a set of optimized desorption parameters and desorption of molecules with a controlled level of fragmentation. The recorded spectra of organic collectors by VUV SALI with laser desorption are characterized by strong parent peaks and simpler fragmentation patterns, which allow for easy molecular identification. Advantages and limitations of the three techniques for analysis of organic collectors on mineral grains are discussed.

  10. Age and microfacies of oceanic Upper Triassic radiolarite components from the Middle Jurassic ophiolitic mélange in the Zlatibor Mountains (Inner Dinarides, Serbia) and their provenance

    NASA Astrophysics Data System (ADS)

    Gawlick, Hans-Jürgen; Djerić, Nevenka; Missoni, Sigrid; Bragin, Nikita Yu.; Lein, Richard; Sudar, Milan; Jovanović, Divna

    2017-08-01

    Oceanic radiolarite components from the Middle Jurassic ophiolitic mélange between Trnava and Rožanstvo in the Zlatibor Mountains (Dinaridic Ophiolite Belt) west of the Drina-Ivanjica unit yield Late Triassic radiolarian ages. The microfacies characteristics of the radiolarites show pure ribbon radiolarites without crinoids or thin-shelled bivalves. Beside their age and the preservation of the radiolarians this points to a deposition of the radiolarites on top of the oceanic crust of the Neo-Tethys, which started to open in the Late Anisian. South of the study area the ophiolitic mélange (Gostilje-Ljubiš-Visoka-Radoševo mélange) contains a mixture of blocks of 1) oceanic crust, 2) Middle and Upper Triassic ribbon radiolarites, and 3) open marine limestones from the continental slope. On the basis of this composition we can conclude that the Upper Triassic radiolarite clasts derive either from 1) the younger parts of the sedimentary succession above the oceanic crust near the continental slope or, more convincingly 2) the sedimentary cover of ophiolites in a higher nappe position, because Upper Triassic ribbon radiolarites are only expected in more distal oceanic areas. The ophiolitic mélange in the study area overlies different carbonate blocks of an underlying carbonate-clastic mélange (Sirogojno mélange). We date and describe three localities with different Upper Triassic radiolarite clasts in a mélange, which occurs A) on top of Upper Triassic fore-reef to reefal limestones (Dachstein reef), B) between an Upper Triassic reefal limestone block and a Lower Carnian reef limestone (Wetterstein reef), and C) in fissures of an Upper Triassic lagoonal to back-reef limestone (Dachstein lagoon). The sedimentary features point to a sedimentary and not to a tectonic emplacement of the ophiolitic mélange (= sedimentary mélange) filling the rough topography of the topmost carbonate-clastic mélange below. The block spectrum of the underlying and slightly older

  11. SIMS analysis of high-performance accelerator niobium

    SciTech Connect

    Maheshwari, P.; Stevie, F. A.; Myneni, Ganapati Rao; Rigsbee, J, M.; Dhakal, Pashupati; Ciovati, Gianluigi; Griffis, D. P.

    2014-11-01

    Niobium is used to fabricate superconducting radio frequency accelerator modules because of its high critical temperature, high critical magnetic field, and easy formability. Recent experiments have shown a very significant improvement in performance (over 100%) after a high-temperature bake at 1400 degrees C for 3h. SIMS analysis of this material showed the oxygen profile was significantly deeper than the native oxide with a shape that is indicative of diffusion. Positive secondary ion mass spectra showed the presence of Ti with a depth profile similar to that of O. It is suspected that Ti is associated with the performance improvement. The source of Ti contamination in the anneal furnace has been identified, and a new furnace was constructed without Ti. Initial results from the new furnace do not show the yield improvement. Further analyses should determine the relationship of Ti to cavity performance.

  12. Li Isotope Studies of Olivine in Mantle Xenoliths by SIMS

    NASA Technical Reports Server (NTRS)

    Bell, D. R.; Hervig, R. L.; Buseck, P. R.

    2005-01-01

    Variations in the ratio of the stable isotopes of Li are a potentially powerful tracer of processes in planetary and nebular environments [1]. Large differences in the 7Li/6Li ratio between the terrestrial upper mantle and various crustal materials make Li isotope composition a potentially powerful tracer of crustal recycling processes on Earth [2]. Recent SIMS studies of terrestrial mantle and Martian meteorite samples report intra-mineral Li isotope zoning [3-5]. Substantial Li isotope heterogeneity also exists within and between the components of chondritic meteorites [6,7]. Experimental studies of Li diffusion suggest the potential for rapid isotope exchange at elevated temperatures [8]. Large variations in 7Li, exceeding the range of unaltered basalts, occur in terrestrial mantle-derived xenoliths from individual localities [9]. The origins of these variations are not fully understood.

  13. Further Studies into Synthetic Image Generation using CameoSim

    DTIC Science & Technology

    2011-08-01

    Sandstone Varnishes and Lake Bed are standard CameoSim Materials. The thermal properties of materials that were changed were the transpiration factor...0.02 0.9 0.005 0.545 2.38 0.002 0.17 Lake Bed 0.5 0.5 10 0.545 2.64 ∞ 0.14 Sandstone 0 0 10 2.7 0.92 ∞ 2.01 Sandstone Varnished 0 0 10 1.7 0.92...Sandstone Quick 3D 1 Quick3D 3 - 1 Varnished Sandstone Quick 3D 1 Quick3D 3 - 1 Lakebed Quick 2D 3 - - - - The material mixes and the bump

  14. Multielement analysis of interplanetary dust particles using TOF-SIMS

    NASA Technical Reports Server (NTRS)

    Stephan, T.; Kloeck, W.; Jessberger, E. K.; Rulle, H.; Zehnpfenning, J.

    1993-01-01

    Sections of three stratospheric particles (U2015G1, W7029*A27, and L2005P9) were analyzed with TOF-SIMS (Time Of Flight-Secondary Ion Mass Spectrometry) continuing our efforts to investigate the element distribution in interplanetary dust particles (IDP's) with high lateral resolution (approximately 0.2 micron), to examine possible atmospheric contamination effects, and to further explore the abilities of this technique for element analysis of small samples. The samples, previously investigated with SXRF (synchrotron X-ray fluorescence analysis), are highly enriched in Br (Br/Fe: 59 x CI, 9.2 x CI, and 116 x CI, respectively). U2015G1 is the IDP with the by far highest Zn/Fe-ratio (81 x CI) ever reported in chondritic particles.

  15. CTA simulations with CORSIKA/sim lowbar telarray

    SciTech Connect

    Bernloehr, K.

    2008-12-24

    While current atmospheric Cherenkov installations consist of only a few telescopes each, future installations will be far more complex. Monte Carlo simulations have become an essential tool for the design and optimisation of such installations. The CORSIKA air-shower simulation code and the sim lowbar telarray code for simulation of arrays of Cherenkov telescopes have been used to simulate several candidate configurations of the future Cherenkov Telescope Array (CTA) in detail. Together with other detailed and simplified simulations the resulting data provide the basis for the ongoing optimisation of CTA over a wide energy range. In this paper, the simulation methods are outlined and preliminary results on a number of configurations are presented. It is demonstrated that the initial goals of the CTA project can be achieved with available technology, at least in the medium and high energy range (about 100 GeV to 100 TeV)

  16. Progress on SIM-Lite brassboard interferometer integration and test

    NASA Astrophysics Data System (ADS)

    Hahn, I.; Weilert, M.; An, X.; Kuan, G.; Hovland, L. E.; Smythe, R.; Hovland, E.; Krylo, R.; Fisher, M.; Chang, Z.; Cepeda-Rizo, J.; Shields, J.; Ahmed, A.; Fathpour, N.; Carson, J.; Nicaise, F.; Morales, M.; Dekens, F.; Goullioud, R.

    2010-07-01

    Main brassboard Michelson interferometer components have been recently developed for the future flight phase implementations of SIM Lite mission. These brassboard components include two fine steering mirrors, pathlength modulation and cyclic averaging optics and astrometric beam combiner assembly. Field-independent performance tests will be performed in a vacuum chamber using two siderostats in retro-reflecting positions and a white light stimulus. The brightness and color dependence of the angle and fringe tracking performance will be measured. The performance of filtering algorithms will be tested in a simulated spacecraft attitude control system perturbation. To demonstrate capability of a dim star observation, the angle and fringe tracking CCD sensors are cooled to -110 C using a cold diode heat pipe system. The new feed-forward control (angle and path-length) algorithms for the dim star observation will be tested as well. In this paper, we will report the recent progress toward the integration and performance tests of the brassboard interferometer.

  17. Caesium sputter ion source compatible with commercial SIMS instruments.

    SciTech Connect

    Belykh, S. F.; Palitsin, V. V.; Veryovkin, I. V.; Kovarsky, A. P.; Chang, R. J. H.; Adriaens, A.; Dowsett, M. G.; Adams, F.; Materials Science Division; Univ. Warwick; Ioffe Physical-Technical Inst.; Ghent Univ.; Univ. Antwerp

    2006-01-01

    A simple design for a caesium sputter cluster ion source compatible with commercially available secondary ion mass spectrometers is reported. This source has been tested with the Cameca IMS 4f instrument using the cluster Si{sub n}{sup -} and Cu{sub n}{sup -} ions, and will shortly be retrofitted to the floating low energy ion gun (FLIG) of the type used on the Cameca 4500/4550 quadruple instruments. Our experiments with surface characterization and depth profiling conducted to date demonstrate improvements of analytical capabilities of the SIMS instrument due to the non-additive enhancement of secondary ion emission and shorter ion ranges of polyatomic projectiles compared to atomic ions with the same impact energy.

  18. Geological evolution of the Coombs Allan Hills area, Ferrar large igneous province, Antarctica: Debris avalanches, mafic pyroclastic density currents, phreatocauldrons

    NASA Astrophysics Data System (ADS)

    Ross, Pierre-Simon; White, James D. L.; McClintock, Murray

    2008-05-01

    The Jurassic Ferrar large igneous province of Antarctica comprises igneous intrusions, flood lavas, and mafic volcaniclastic deposits (now lithified). The latter rocks are particularly diverse and well-exposed in the Coombs-Allan Hills area of South Victoria Land, where they are assigned to the Mawson Formation. In this paper we use these rocks in conjunction with the pre-Ferrar sedimentary rocks (Beacon Supergroup) and the lavas themselves (Kirkpatrick Basalt) to reconstruct the geomorphological and geological evolution of the landscape. In the Early Jurassic, the surface of the region was an alluvial plain, with perhaps 1 km of mostly continental siliciclastic sediments underlying it. After the fall of silicic ash from an unknown but probably distal source, mafic magmatism of the Ferrar province began. The oldest record of this event at Allan Hills is a ≤ 180 m-thick debris-avalanche deposit (member m1 of the Mawson Formation) which contains globular domains of mafic igneous rock. These domains are inferred to represent dismembered Ferrar intrusions emplaced in the source area of the debris avalanche; shallow emplacement of Ferrar magmas caused a slope failure that mobilized the uppermost Beacon Supergroup, and the silicic ash deposits, into a pre-existing valley or basin. The period which followed ('Mawson time') was the main stage for explosive eruptions in the Ferrar province, and several cubic kilometres of both new magma and sedimentary rock were fragmented over many years. Phreatomagmatic explosions were the dominant fragmentation mechanism, with magma-water interaction taking place in both sedimentary aquifers and existing vents filled by volcaniclastic debris. At Coombs Hills, a vent complex or 'phreatocauldron' was formed by coalescence of diatreme-like structures; at Allan Hills, member m2 of the Mawson Formation consists mostly of thick, coarse-grained, poorly sorted layers inferred to represent the lithified deposits of pyroclastic density currents

  19. Transformation of Printed Course Materials into Self Instructional Materials (SIMs): Some Basic Issues.

    ERIC Educational Resources Information Center

    Rausaria, R. R.; Bhushan, Bharat

    2001-01-01

    Discussion of the use of self-instructional materials (SIMs) in distance learning at Indira Gandhi National Open University (IGNOU) and State Open Universities (SOUs) in India. Focuses on the need for Correspondence Course Institutes in conventional Indian universities to transform printed course materials into SIMs. Discusses revision and…

  20. Transformation of Printed Course Materials into Self Instructional Materials (SIMs): Some Basic Issues.

    ERIC Educational Resources Information Center

    Rausaria, R. R.; Bhushan, Bharat

    2001-01-01

    Discussion of the use of self-instructional materials (SIMs) in distance learning at Indira Gandhi National Open University (IGNOU) and State Open Universities (SOUs) in India. Focuses on the need for Correspondence Course Institutes in conventional Indian universities to transform printed course materials into SIMs. Discusses revision and…