Sample records for languages cdc mobile

  1. Group B Strep Infection in Newborns

    MedlinePlus

    ... Active Bacterial Core surveillance (ABCs) CDC Streptococcus Laboratory Sepsis Group B Strep Disease in Newborns Language: English ( ... Active Bacterial Core surveillance (ABCs) CDC Streptococcus Laboratory Sepsis Language: English (US) Español (Spanish) File Formats Help: ...

  2. 78 FR 27396 - Statement of Organization, Functions, and Delegations of Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... scientific basis for communication and marketing practice; (2) guides CIOs on applying measures of... and marketing research to interested professionals at CDC, its partners, and other stakeholders; and... media channels, including CDC.gov top tier, CDC en Espanol, mobile apps, and CDC Connects; (4...

  3. Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion.

    PubMed

    Sartorel, Elodie; Ünlü, Caner; Jose, Mini; Massoni-Laporte, Aurélie; Meca, Julien; Sibarita, Jean-Baptiste; McCusker, Derek

    2018-04-18

    The anisotropic organization of plasma membrane constituents is indicative of mechanisms that drive the membrane away from equilibrium. However, defining these mechanisms is challenging due to the short spatio-temporal scales at which diffusion operates. Here, we use high-density single protein tracking combined with photoactivation localization microscopy (sptPALM) to monitor Cdc42 in budding yeast, a system in which Cdc42 exhibits anisotropic organization. Cdc42 exhibited reduced mobility at the cell pole, where it was organized in nanoclusters. The Cdc42 nanoclusters were larger at the cell pole than those observed elsewhere in the cell. These features were exacerbated in cells expressing Cdc42-GTP, and were dependent on the scaffold Bem1, which contributed to the range of mobility and nanocluster size exhibited by Cdc42. The lipid environment, in particular phosphatidylserine levels, also played a role in regulating Cdc42 nanoclustering. These studies reveal how the mobility of a Rho GTPase is controlled to counter the depletive effects of diffusion, thus stabilizing Cdc42 on the plasma membrane and sustaining cell polarity. Movie S1 Movie S1 sptPALM imaging of live yeast expressing Pil1-mEOS expressed at the genomic locus. Pil1-mEOS was simultaneously photo-converted with a 405 nm laser and imaged with a 561 nm laser using HiLo illumination. Images were acquired at 20 ms intervals, of which 300 frames are shown at 7 frames per second.

  4. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

    PubMed Central

    Izumi, T; Maller, J L

    1993-01-01

    The cdc25 phosphatase is a mitotic inducer that activates p34cdc2 at the G2/M transition by dephosphorylation of Tyr15 in p34cdc2. cdc25 itself is also regulated through periodic changes in its phosphorylation state. To elucidate the mechanism for induction of mitosis, phosphorylation of cdc25 has been investigated using recombinant proteins. cdc25 is phosphorylated by both cyclin A/p34cdc2 and cyclin B/p34cdc2 at similar sets of multiple sites in vitro. This phosphorylation retards its electrophoretical mobility and activates its ability to increase cyclin B/p34cdc2 kinase activity three- to fourfold in vitro, as found for endogenous Xenopus cdc25 in M-phase extracts. The threonine and serine residues followed by proline that are conserved between Xenopus and human cdc25 have been mutated. Both the triple mutation of Thr48, Thr67, and Thr138 and the quintuple mutation of these three threonine residues plus Ser205 and Ser285, almost completely abolish the shift in electrophoretic mobility of cdc25 after incubation with M-phase extracts or phosphorylation by p34cdc2. These mutations inhibit the activation of cdc25 by phosphorylation with p34cdc2 by 70 and 90%, respectively. At physiological concentrations these mutants cannot activate cyclin B/p34cdc2 in cdc25-immunodepleted oocyte extracts, suggesting that a positive feed-back loop between cdc2 and cdc25 is necessary for the full activation of cyclin B/p34cdc2 that induces abrupt entry into mitosis in vivo. Images PMID:7513216

  5. CDC Kerala 7: Effect of early language intervention among children 0-3 y with speech and language delay.

    PubMed

    Nair, M K C; Mini, A O; Leena, M L; George, Babu; Harikumaran Nair, G S; Bhaskaran, Deepa; Russell, Paul Swamidhas Sudhakar

    2014-12-01

    To assess the effect of systematic clinic and home based early language intervention program in children reporting to the early language intervention clinic with full partnership of specially trained developmental therapist and the parents. All babies between 0 and 3 y referred to Child Development Centre (CDC) Kerala for suspected speech/language delay were assessed and those without hearing impairment were screened first using Language Evaluation Scale Trivandrum (LEST) and assessed in detail using Receptive Expressive Emergent Language Scale (REELS). Those having language delay are enrolled into the early language intervention program for a period of 6 mo, 1 h at the CDC clinic once every month followed by home stimulation for rest of the month by the mother trained at CDC. Out of the total 455 children between 0 and 3 y, who successfully completed 6 mo intervention, the mean pre and post intervention language quotient (LQ) were 60.79 and 70.62 respectively and the observed 9.83 increase was statistically significant. The developmental diagnosis included developmental delay (62.4%), global developmental delay (18.5%), Trisomy and other chromosomal abnormalities (10.5%), microcephaly and other brain problems (9.9%), misarticulation (8.4%), autistic features (5.3%) and cleft palate and lip (3.3%) in the descending order. In the present study among 455 children between 0 and 3 y without hearing impairment, who successfully completed 6 mo early language intervention, the mean pre and post intervention LQ were 60.79 and 70.62 respectively and the observed 9.83 increase was statistically significant.

  6. INFOL for the CDC 6400 Information Storage and Retrieval System. Reference Manual.

    ERIC Educational Resources Information Center

    Mittman, B.; And Others

    INFOL for the CDC 6400 is a rewrite in FORTRAN IV of the CDC 3600/3800 INFOL (Information Oriented Language), a generalized information storage and retrieval system developed by the Control Data Corporation for the CDC 3600/3800 computer. With INFOL, selected pieces of information are extracted from a file and presented to the user quickly and…

  7. Implementation of the Hong Kong Language Policy in Pre-School Settings

    ERIC Educational Resources Information Center

    Leung, Cheung-Shing Sam; Lim, Swee Eng Audrey; Li, Yuen Ling

    2013-01-01

    In the past, the Curriculum Development Council in Hong Kong [Curriculum Development Council (CDC). (1996). "Guide to the Pre-Primary Curriculum." Hong Kong: Government Printer; CDC. (2000). "Consultation Document: Learning to Learn: The Way Forward in Curriculum Development." Hong Kong: Government Printer; CDC. (2001).…

  8. Gonorrhea

    MedlinePlus

    ... Search Form Controls Cancel Submit Search the CDC Gonorrhea Note: Javascript is disabled or is not supported ... Twitter STD on Facebook Sexually Transmitted Diseases (STDs) Gonorrhea - CDC Fact Sheet Language: English (US) Español (Spanish) ...

  9. CDC to CRAY FORTRAN conversion manual

    NASA Technical Reports Server (NTRS)

    Mcgary, C.; Diebert, D.

    1983-01-01

    Documentation describing software differences between two general purpose computers for scientific applications is presented. Descriptions of the use of the FORTRAN and FORTRAN 77 high level programming language on a CDC 7600 under SCOPE and a CRAY XMP under COS are offered. Itemized differences of the FORTRAN language sets of the two machines are also included. The material is accompanied by numerous examples of preferred programming techniques for the two machines.

  10. Establishment of CDC Global Rapid Response Team to Ensure Global Health Security.

    PubMed

    Stehling-Ariza, Tasha; Lefevre, Adrienne; Calles, Dinorah; Djawe, Kpandja; Garfield, Richard; Gerber, Michael; Ghiselli, Margherita; Giese, Coralie; Greiner, Ashley L; Hoffman, Adela; Miller, Leigh Ann; Moorhouse, Lisa; Navarro-Colorado, Carlos; Walsh, James; Bugli, Dante; Shahpar, Cyrus

    2017-12-01

    The 2014-2016 Ebola virus disease epidemic in West Africa highlighted challenges faced by the global response to a large public health emergency. Consequently, the US Centers for Disease Control and Prevention established the Global Rapid Response Team (GRRT) to strengthen emergency response capacity to global health threats, thereby ensuring global health security. Dedicated GRRT staff can be rapidly mobilized for extended missions, improving partner coordination and the continuity of response operations. A large, agencywide roster of surge staff enables rapid mobilization of qualified responders with wide-ranging experience and expertise. Team members are offered emergency response training, technical training, foreign language training, and responder readiness support. Recent response missions illustrate the breadth of support the team provides. GRRT serves as a model for other countries and is committed to strengthening emergency response capacity to respond to outbreaks and emergencies worldwide, thereby enhancing global health security.

  11. CDC Vital Signs: Preventing Melanoma

    MedlinePlus

    ... not use the device. Include warning statements in marketing materials about the risk of using the device. ... MB] en Español [PDF – 1.16 MB] CDC Digital Press Kit Read the MMWR Science Clips Language: ...

  12. Role of STD Detection and Treatment in HIV Prevention

    MedlinePlus

    ... Search Form Controls Cancel Submit Search the CDC HIV/AIDS & STDs Note: Javascript is disabled or is ... on Facebook Sexually Transmitted Diseases (STDs) STDs and HIV – CDC Fact Sheet Language: English (US) Español (Spanish) ...

  13. Collection of Data on Race, Ethnicity, Language, and Nativity by US Public Health Surveillance and Monitoring Systems: Gaps and Opportunities.

    PubMed

    Rodriguez-Lainz, Alfonso; McDonald, Mariana; Fonseca-Ford, Maureen; Penman-Aguilar, Ana; Waterman, Stephen H; Truman, Benedict I; Cetron, Martin S; Richards, Chesley L

    Despite increasing diversity in the US population, substantial gaps in collecting data on race, ethnicity, primary language, and nativity indicators persist in public health surveillance and monitoring systems. In addition, few systems provide questionnaires in foreign languages for inclusion of non-English speakers. We assessed (1) the extent of data collected on race, ethnicity, primary language, and nativity indicators (ie, place of birth, immigration status, and years in the United States) and (2) the use of data-collection instruments in non-English languages among Centers for Disease Control and Prevention (CDC)-supported public health surveillance and monitoring systems in the United States. We identified CDC-supported surveillance and health monitoring systems in place from 2010 through 2013 by searching CDC websites and other federal websites. For each system, we assessed its website, documentation, and publications for evidence of the variables of interest and use of data-collection instruments in non-English languages. We requested missing information from CDC program officials, as needed. Of 125 data systems, 100 (80%) collected data on race and ethnicity, 2 more collected data on ethnicity but not race, 26 (21%) collected data on racial/ethnic subcategories, 40 (32%) collected data on place of birth, 21 (17%) collected data on years in the United States, 14 (11%) collected data on immigration status, 13 (10%) collected data on primary language, and 29 (23%) used non-English data-collection instruments. Population-based surveys and disease registries more often collected data on detailed variables than did case-based, administrative, and multiple-source systems. More complete and accurate data on race, ethnicity, primary language, and nativity can improve the quality, representativeness, and usefulness of public health surveillance and monitoring systems to plan and evaluate targeted public health interventions to eliminate health disparities.

  14. What Are Common Symptoms of Down Syndrome?

    MedlinePlus

    ... 91, 1463–1477. CDC. (2012). World Down syndrome day . Retrieved June 11, 2012, from http://www.cdc.gov/ncbddd/birthdefects/features/DownSyndromeWorldDay-2012.html Martin, G. E., Klusek, J., Estigarribia, B., & Roberts, J. E. (2009). Language characteristics ...

  15. PTT Advisor: A CDC-supported initiative to develop a mobile clinical laboratory decision support application for the iOS platform

    PubMed Central

    Savel, Thomas G.; Lee, Brian A.; Ledbetter, Greg; Brown, Sara; LaValley, Dale; Taylor, Julie; Thompson, Pam

    2013-01-01

    Objectives: This manuscript describes the development of PTT (Partial Thromboplastin Time) Advisor, one of the first of a handful of iOS-based mobile applications to be released by the US Centers for Disease Control and Prevention (CDC). PTT Advisor has been a collaboration between two groups at CDC (Informatics R&D and Laboratory Science), and one partner team (Clinical Laboratory Integration into Healthcare Collaborative - CLIHC). The application offers clinicians a resource to quickly select the appropriate follow-up tests to evaluate patients with a prolonged PTT and a normal Prothrombin Time (PT) laboratory result. Methods: The application was designed leveraging an agile methodology, and best practices in user experience (UX) design and mobile application development. Results: As it is an open-source project, the code to PTT Advisor was made available to the public under the Apache Software License. On July 6, 2012, the free app was approved by Apple, and was published to their App Store. Conclusions: Regardless of the complexity of the mobile application, the level of effort required in the development process should not be underestimated. There are several issues that make designing the UI for a mobile phone challenging (not just small screen size): the touchscreen, users' mobile mindset (tasks need to be quick and focused), and the fact that mobile UI conventions/expectations are still being defined and refined (due to the maturity level of the field of mobile application development). PMID:23923100

  16. PTT Advisor: A CDC-supported initiative to develop a mobile clinical laboratory decision support application for the iOS platform.

    PubMed

    Savel, Thomas G; Lee, Brian A; Ledbetter, Greg; Brown, Sara; Lavalley, Dale; Taylor, Julie; Thompson, Pam

    2013-01-01

    This manuscript describes the development of PTT (Partial Thromboplastin Time) Advisor, one of the first of a handful of iOS-based mobile applications to be released by the US Centers for Disease Control and Prevention (CDC). PTT Advisor has been a collaboration between two groups at CDC (Informatics R&D and Laboratory Science), and one partner team (Clinical Laboratory Integration into Healthcare Collaborative - CLIHC). The application offers clinicians a resource to quickly select the appropriate follow-up tests to evaluate patients with a prolonged PTT and a normal Prothrombin Time (PT) laboratory result. The application was designed leveraging an agile methodology, and best practices in user experience (UX) design and mobile application development. As it is an open-source project, the code to PTT Advisor was made available to the public under the Apache Software License. On July 6, 2012, the free app was approved by Apple, and was published to their App Store. Regardless of the complexity of the mobile application, the level of effort required in the development process should not be underestimated. There are several issues that make designing the UI for a mobile phone challenging (not just small screen size): the touchscreen, users' mobile mindset (tasks need to be quick and focused), and the fact that mobile UI conventions/expectations are still being defined and refined (due to the maturity level of the field of mobile application development).

  17. A Child Development Centre (C.D.C.) Based on the World of Work and Everyday Life: A Case of Quality Education Provision for 2.5-5 Year Old Children.

    ERIC Educational Resources Information Center

    Frangos, Christos

    1993-01-01

    Outlines the organization and activities of the Child Development Centre (CDC) of Aristotle University in Thessaloniki, which operates as a model preschool and kindergarten for over 300 similar institutions throughout Greece. The CDC utilizes art, music, visits to workplaces, movement activities, foreign languages and customs, computers,and free…

  18. Experience with a vectorized general circulation weather model on Star-100

    NASA Technical Reports Server (NTRS)

    Soll, D. B.; Habra, N. R.; Russell, G. L.

    1977-01-01

    A version of an atmospheric general circulation model was vectorized to run on a CDC STAR 100. The numerical model was coded and run in two different vector languages, CDC and LRLTRAN. A factor of 10 speed improvement over an IBM 360/95 was realized. Efficient use of the STAR machine required some redesigning of algorithms and logic. This precludes the application of vectorizing compilers on the original scalar code to achieve the same results. Vector languages permit a more natural and efficient formulation for such numerical codes.

  19. PORTABLE LISP; a list-processing interpreter. [CDC7600; PASCAL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taylor, W.P.

    The program constitutes a complete, basic LISP (LIST-Processing language) interpreter. LISP expressions are evaluated one by one with both the input expression and the resulting evaluated expression printed. Expressions are evaluated until a FIN card is encountered. Between expression evaluations a garbage-collection algorithm is invoked to recover list space used in the previous evaluation.CDC7600; PASCAL; SCOPE; The sample problem was executed in 7000 (octal) words of memory on a CDC7600.

  20. 75 FR 8725 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    .... Proposed Project CDC Web site and Communication Channels Usability Evaluation, (OMB no. 0925-0735, exp. 3/31/2010)--Revision--National Center for Health Marketing (NCHM), Centers for Disease Control and..., mobile-based or other electronic communication channels hosting CDC content on an ongoing basis. It is...

  1. Hough transform method for track finding in center drift chamber

    NASA Astrophysics Data System (ADS)

    Azmi, K. A. Mohammad Kamal; Wan Abdullah, W. A. T.; Ibrahim, Zainol Abidin

    2016-01-01

    Hough transform is a global tracking method used which had been expected to be faster approach for tracking the circular pattern of electron moving in Center Drift Chamber (CDC), by transforming the point of hit into a circular curve. This paper present the implementation of hough transform method for the reconstruction of tracks in Center Drift Chamber (CDC) which have been generated by random number in C language programming. Result from implementation of this method shows higher peak of circle parameter value (xc,yc,rc) that indicate the similarity value of the parameter needed for circular track in CDC for charged particles in the region of CDC.

  2. Public Health Research at the CDC: Implications for Communication Sciences and Disorders

    ERIC Educational Resources Information Center

    Boyle, C.; Alexander, M.

    2005-01-01

    The following paper provides an overview of public health research at the Centers for Disease Control and Prevention (CDC), with emphasis on research involving speech, language and hearing disorders. Public health research involves a sequence of activities from disease tracking to disease prevention. Public health focuses on populations and works…

  3. Expressive Language in Preschoolers Born Preterm: Results of Language Sample Analysis and Standardized Assessment

    ERIC Educational Resources Information Center

    Imgrund, Caitlin

    2017-01-01

    Children born preterm constitute one of the largest populations of children at risk for the development of language impairments. A little over one in ten pregnancies result in a preterm birth and approximately 25% of these children go on to experience subsequent difficulties with language (CDC, 2015; Foster-Cohen, Friesen, Champion, &…

  4. Hough transform method for track finding in center drift chamber

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Azmi, K. A. Mohammad Kamal, E-mail: khasmidatul@siswa.um.edu.my; Wan Abdullah, W. A. T., E-mail: wat@um.edu.my; Ibrahim, Zainol Abidin

    Hough transform is a global tracking method used which had been expected to be faster approach for tracking the circular pattern of electron moving in Center Drift Chamber (CDC), by transforming the point of hit into a circular curve. This paper present the implementation of hough transform method for the reconstruction of tracks in Center Drift Chamber (CDC) which have been generated by random number in C language programming. Result from implementation of this method shows higher peak of circle parameter value (xc,yc,rc) that indicate the similarity value of the parameter needed for circular track in CDC for charged particlesmore » in the region of CDC.« less

  5. Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.

    PubMed

    Field, K A; Apgar, J R; Hong-Geller, E; Siraganian, R P; Baird, B; Holowka, D

    2000-10-01

    Characterization of defects in a variant subline of RBL mast cells has revealed a biochemical event proximal to IgE receptor (Fc epsilon RI)-stimulated tyrosine phosphorylation that is required for multiple functional responses. This cell line, designated B6A4C1, is deficient in both Fc epsilon RI-mediated degranulation and biosynthesis of several lipid raft components. Agents that bypass receptor-mediated Ca(2+) influx stimulate strong degranulation responses in these variant cells. Cross-linking of IgE-Fc epsilon RI on these cells stimulates robust tyrosine phosphorylation but fails to mobilize a sustained Ca(2+) response. Fc epsilon RI-mediated inositol phosphate production is not detectable in these cells, and failure of adenosine receptors to mobilize Ca(2+) suggests a general deficiency in stimulated phospholipase C activity. Antigen stimulation of phospholipases A(2) and D is also defective. Infection of B6A4C1 cells with vaccinia virus constructs expressing constitutively active Rho family members Cdc42 and Rac restores antigen-stimulated degranulation, and active Cdc42 (but not active Rac) restores ganglioside and GPI expression. The results support the hypothesis that activation of Cdc42 and/or Rac is critical for Fc epsilon RI-mediated signaling that leads to Ca(2+) mobilization and degranulation. Furthermore, they suggest that Cdc42 plays an important role in the biosynthesis and expression of certain components of lipid rafts.

  6. Breast Cancer Rates by State

    MedlinePlus

    ... Trends What CDC Is Doing Research African American Women and Mass Media Campaign Public Service Announcements Print Materials ... Cancer Home Breast Cancer Rates by State Language: English (US) ...

  7. Breast Cancer Trends

    MedlinePlus

    ... Trends What CDC Is Doing Research African American Women and Mass Media Campaign Public Service Announcements Print Materials The Right to ... Cancer Trends Language: English Español (Spanish) Recommend ...

  8. CDL description of the CDC 6600 stunt box

    NASA Technical Reports Server (NTRS)

    Hertzog, J. B.

    1971-01-01

    The CDC 6600 central memory control (stunt box) is described utilizing CDL (Computer Design Language), block diagrams, and text. The stunt box is a clearing house for all central memory references from the 6600 central and peripheral processors. Since memory requests can be issued simultaneously, the stunt box must be capable of assigning priorities to requests, of labeling requests so that the data will be distributed correctly, and of remembering rejected addresses due to memory conflicts.

  9. Breast Cancer Rates by Race and Ethnicity

    MedlinePlus

    ... Trends What CDC Is Doing Research African American Women and Mass Media Campaign Public Service Announcements Print Materials ... Cancer Home Breast Cancer Rates by Race and Ethnicity Language: ...

  10. Learners' Perceptions of the Use of Mobile Technology in a Task-Based Language Teaching Experience

    ERIC Educational Resources Information Center

    Calabrich, Simone L.

    2016-01-01

    This research explored perceptions of learners studying English in private language schools regarding the use of mobile technology to support language learning. Learners were first exposed to both a mobile assisted and a mobile unassisted language learning experience, and then asked to express their thoughts on the incorporation of mobile devices…

  11. Disability and Obesity

    MedlinePlus

    ... CDC Employees and Reasonable Accommodations (RA) Disability and Obesity Language: English (US) Español (Spanish) Recommend on Facebook ... and Disability at http://www.ncpad.org/ The Obesity Epidemic Obesity affects different people in different ways ...

  12. HPV-Associated Cancers Statistics

    MedlinePlus

    ... What CDC Is Doing Related Links Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Vaginal and Vulvar Cancer Home HPV-Associated Cancer Statistics Language: English (US) Español (Spanish) Recommend on Facebook ...

  13. Syphilis and MSM (Men Who Have Sex with Men)

    MedlinePlus

    ... Transmitted Diseases (STDs) Syphilis & MSM (Men Who Have Sex With Men) - CDC Fact Sheet Language: English (US) ... among gay, bisexual, and other men who have sex with men (MSM). MSM Fact Sheet | View Images ...

  14. CDC Vital Signs: Progress on Childhood Obesity

    MedlinePlus

    ... Read the MMWR Science Clips Progress on Childhood Obesity Many States Show Declines Language: English (US) Español ( ... 8 preschoolers is obese in the US. 19 Obesity among low-income preschoolers declined, from 2008 through ...

  15. CDC Vital Signs: Hospital Actions Affect Breastfeeding

    MedlinePlus

    ... Read the MMWR Science Clips Hospital Actions Affect Breastfeeding Language: English (US) Español (Spanish) Recommend on Facebook ... in many US hospitals do not fully support breastfeeding. Some of the Ten Steps on which hospitals ...

  16. User manual for Streamtube Curvature Analysis: Analytical method for predicting the pressure distribution about a nacelle at transonic speeds, appendix

    NASA Technical Reports Server (NTRS)

    Keith, J. S.; Ferguson, D. R.; Heck, P. H.

    1973-01-01

    The computer program listing of Streamtube Curvature Analysis is presented. The listing includes explanatory statements and titles so that the program flow is readily discernable. The computer program listing is in CDC FORTRAN 2.3 source language form, except for three subroutines, GETIX, GETRLX, and SAVIX, which are in COMPOSE 1.1 language.

  17. Basic linear algebra subprograms for FORTRAN usage

    NASA Technical Reports Server (NTRS)

    Lawson, C. L.; Hanson, R. J.; Kincaid, D. R.; Krogh, F. T.

    1977-01-01

    A package of 38 low level subprograms for many of the basic operations of numerical linear algebra is presented. The package is intended to be used with FORTRAN. The operations in the package are dot products, elementary vector operations, Givens transformations, vector copy and swap, vector norms, vector scaling, and the indices of components of largest magnitude. The subprograms and a test driver are available in portable FORTRAN. Versions of the subprograms are also provided in assembly language for the IBM 360/67, the CDC 6600 and CDC 7600, and the Univac 1108.

  18. Mobile Assisted Language Learning: Review of the Recent Applications of Emerging Mobile Technologies

    ERIC Educational Resources Information Center

    Yang, Jaeseok

    2013-01-01

    As mobile computing technologies have been more powerful and inclusive in people's daily life, the issue of mobile assisted language learning (MALL) has also been widely explored in CALL research. Many researches on MALL consider the emerging mobile technologies have considerable potentials for the effective language learning. This review study…

  19. What Is a Mammogram and When Should I Get One?

    MedlinePlus

    ... Statistics What CDC Is Doing Research African American Women and Mass Media Campaign Public Service Announcements Print Materials Buttons and Badges Stay Informed Cancer Home What Is a Mammogram? Language: English (US) Español ( ...

  20. Situation Update: Summary of Weekly FluView

    MedlinePlus

    ... Pandemic Other Situation Update: Summary of Weekly FluView Report Language: English (US) Español Recommend on Facebook Tweet ... Influenza Positive Tests Reported to CDC The FluView report published on May 25 marks the final full ...

  1. CDC Vital Signs: Heart Age - Is Your Heart Older Than You?

    MedlinePlus

    ... Digital Press Kit Read the MMWR Science Clips Heart Age Is Your Heart Older Than You? Language: ... that increase heart age. Problem US adults have hearts 7 years older than they should be. Though ...

  2. CDC Vital Signs: Making Health Care Safer -- Think Sepsis. Time Matters.

    MedlinePlus

    ... Press Kit Read the MMWR Science Clips Making Health Care Safer Think sepsis. Time matters. Language: English (US) ... the antibiotic type, dose, and duration are correct. Health care facility CEOs/administrators can Make infection control a ...

  3. CDC Vital Signs: Blood Pressure Control -- Helping Patients Take Their Medicine

    MedlinePlus

    ... Kit Read the MMWR Science Clips Blood Pressure Control Helping Patients Take Their Medicine Language: English (US) ... pressure and only about half have it under control (less than 140/90 mmHg). Blood pressure medicine ( ...

  4. LingoBee--Crowd-Sourced Mobile Language Learning in the Cloud

    ERIC Educational Resources Information Center

    Petersen, Sobah Abbas; Procter-Legg, Emma; Cacchione, Annamaria

    2013-01-01

    This paper describes three case studies, where language learners were invited to use "LingoBee" as a means of supporting their language learning. LingoBee is a mobile app that provides user-generated language content in a cloud-based shared repository. Assuming that today's students are mobile savvy and "Digital Natives" able…

  5. LingoBee: Engaging Mobile Language Learners through Crowd-Sourcing

    ERIC Educational Resources Information Center

    Petersen, Sobah Abbas; Procter-Legg, Emma; Cacchione, Annamaria

    2014-01-01

    This paper describes three case studies, where language learners were invited to use "LingoBee" as a means of supporting their language learning. LingoBee is a mobile app that provides user-generated language content in a cloud-based shared repository. Assuming that today's students are mobile savvy and "Digital Natives" able…

  6. Practical Evaluation of a Mobile Language Learning Tool in Higher Education

    ERIC Educational Resources Information Center

    Kétyi, András

    2015-01-01

    Following on preliminary research (Kétyi, 2013), in this project we looked for a mobile language learning solution, which combines computers and mobile devices. Our main idea was to explore whether by integrating mobile devices in our language teaching practice, our students at the Budapest Business School would gain valuable additional learning…

  7. Tablets for Informal Language Learning: Student Usage and Attitudes

    ERIC Educational Resources Information Center

    Chen, Xiao-Bin

    2013-01-01

    Mobile-assisted language learning (MALL), a relatively new area of CALL inquiry, is gaining more and more attention from language educators with the development of new mobile devices. Tablet computers--featuring high mobility, convenient network connectivity, and smart application extendibility--are part of a wave of the latest mobile inventions;…

  8. Mobile City and Language Guides--New Links between Formal and Informal Learning Environments

    ERIC Educational Resources Information Center

    Bo-Kristensen, Mads; Ankerstjerne, Niels Ole; Neutzsky-Wulff, Chresteria; Schelde, Herluf

    2009-01-01

    One of the major challenges in second and foreign language education, is to create links between formal and informal learning environments. Mobile City and Language Guides present examples of theoretical and practical reflections on such links. This paper presents and discusses the first considerations of Mobile City and Language Guides in…

  9. Technological Readiness of UiTM Students in Using Mobile Phones in the English Language Classroom

    ERIC Educational Resources Information Center

    Murugan, Agelyia; Sai, George Teoh Boon; Lin, Agnes Liau Wei

    2017-01-01

    Mobile Assisted Language Learning (MALL) by using devices such as mobile phones is an ideal learning platform for learners to acquire language and share knowledge beyond the confines of a fixed location. By utilizing the mobile applications available via smartphone, learners can engage in collaborative networks and find information in a variety of…

  10. ScaMo: Realisation of an OO-functional DSL for cross platform mobile applications development

    NASA Astrophysics Data System (ADS)

    Macos, Dragan; Solymosi, Andreas

    2013-10-01

    The software market is dynamically changing: the Internet is going mobile, the software applications are shifting from the desktop hardware onto the mobile devices. The largest markets are the mobile applications for iOS, Android and Windows Phone and for the purpose the typical programming languages include Objective-C, Java and C ♯. The realization of the native applications implies the integration of the developed software into the environments of mentioned mobile operating systems to enable the access to different hardware components of the devices: GPS module, display, GSM module, etc. This paper deals with the definition and possible implementation of an environment for the automatic application generation for multiple mobile platforms. It is based on a DSL for mobile application development, which includes the programming language Scala and a DSL defined in Scala. As part of a multi-stage cross-compiling algorithm, this language is translated into the language of the affected mobile platform. The advantage of our method lies in the expressiveness of the defined language and the transparent source code translation between different languages, which implies, for example, the advantages of debugging and development of the generated code.

  11. Transform Modern Language Learning through Mobile Devices

    ERIC Educational Resources Information Center

    Tuttle, Harry Grover

    2013-01-01

    College professors can transform their modern language classes through mobile devices. Their students' learning becomes more active, more personalized, more contextual, and more culturally authentic as illustrated through the author's modern language mobile learning classroom examples. In addition, their students engage in many diverse types of…

  12. Ebola in West Africa--CDC's Role in Epidemic Detection, Control, and Prevention.

    PubMed

    Frieden, Thomas R; Damon, Inger K

    2015-11-01

    Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays. Efforts have included supporting incident management systems in affected countries; mobilizing partners; and strengthening laboratory, epidemiology, contact investigation, health care infection control, communication, and border screening in West Africa, Nigeria, Mali, Senegal, and the United States. All efforts were undertaken as part of national and global response activities with many partner organizations. CDC was able to support community, national, and international health and public health staff to prevent an even worse event. The Ebola virus disease epidemic highlights the need to strengthen national and international systems to detect, respond to, and prevent the spread of future health threats.

  13. Mobile-Assisted Second Language Learning: Developing a Learner-Centered Framework

    ERIC Educational Resources Information Center

    Leow, Choy Khim; Yahaya, Wan Ahmad Jaafar Wan; Samsudin, Zarina

    2014-01-01

    The Mobile Assisted Language Learning concept has offered infinite language learning opportunities since its inception 20 years ago. Second Language Acquisition however embraces a considerably different body of knowledge from first language learning. While technological advances have optimized the psycholinguistic environment for language…

  14. Language Learners Perceptions and Experiences on the Use of Mobile Applications for Independent Language Learning in Higher Education

    ERIC Educational Resources Information Center

    Niño, Ana

    2015-01-01

    With the widespread use of mobile phones and portable devices it is inevitable to think of Mobile Assisted Language Learning as a means of independent learning in Higher Education. Nowadays many learners are keen to explore the wide variety of applications available in their portable and always readily available mobile phones and tablets. The fact…

  15. A Review of Integrating Mobile Phones for Language Learning

    ERIC Educational Resources Information Center

    Darmi, Ramiza; Albion, Peter

    2014-01-01

    Mobile learning (m-learning) is gradually being introduced in language classrooms. All forms of mobile technology represent portability with smarter features. Studies have proven the concomitant role of technology beneficial for language learning. Various features in the technology have been exploited and researched for acquiring and learning…

  16. Mobile Collaborative Language Learning: State of the Art

    ERIC Educational Resources Information Center

    Kukulska-Hulme, Agnes; Viberg, Olga

    2018-01-01

    This paper presents a review of mobile collaborative language learning studies published in 2012-16 with the aim to improve understanding of how mobile technologies have been used to support collaborative learning among second and foreign language students. We identify affordances, general pedagogical approaches, second- and foreign-language…

  17. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  18. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  19. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  20. 40 CFR 141.154 - Required additional health information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Required additional health information... Required additional health information. (a) All reports must prominently display the following language... from their health care providers. EPA/CDC guidelines on appropriate means to lessen the risk of...

  1. Epi info - present and future.

    PubMed

    Su, Y; Yoon, S S

    2003-01-01

    Epi Info is a suite of public domain computer programs for public health professionals developed by the Centers for Disease Control and Prevention (CDC). Epi Info is used for rapid questionnaire design, data entry and validation, data analysis including mapping and graphing, and creation of reports. Epi Info was originally created in 1985 using Turbo Pascal. In 1998, the last version of Epi Info for DOS, version 6, was released. Epi Info for DOS is currently supported by CDC but is no longer updated. The current version, Epi Info 2002, is Windows-based software developed using Microsoft Visual Basic. Approximately 300,000 downloads of Epi Info software occurred in 2002 from approximately 130 countries. These numbers make Epi Info probably one of the most widely distributed and used public domain programs in the world. The DOS version of Epi Info was translated into 13 languages, and efforts are underway to translate the Windows version into other major languages. Versions already exist for Spanish, French, Portuguese, Chinese, Japanese, and Arabic.

  2. Language competition in a population of migrating agents.

    PubMed

    Lipowska, Dorota; Lipowski, Adam

    2017-05-01

    Influencing various aspects of human activity, migration is associated also with language formation. To examine the mutual interaction of these processes, we study a Naming Game with migrating agents. The dynamics of the model leads to formation of low-mobility clusters, which turns out to break the symmetry of the model: although the Naming Game remains symmetric, low-mobility languages are favored. High-mobility languages are gradually eliminated from the system, and the dynamics of language formation considerably slows down. Our model is too simple to explain in detail language competition of migrating human communities, but it certainly shows that languages of settlers are favored over nomadic ones.

  3. Language competition in a population of migrating agents

    NASA Astrophysics Data System (ADS)

    Lipowska, Dorota; Lipowski, Adam

    2017-05-01

    Influencing various aspects of human activity, migration is associated also with language formation. To examine the mutual interaction of these processes, we study a Naming Game with migrating agents. The dynamics of the model leads to formation of low-mobility clusters, which turns out to break the symmetry of the model: although the Naming Game remains symmetric, low-mobility languages are favored. High-mobility languages are gradually eliminated from the system, and the dynamics of language formation considerably slows down. Our model is too simple to explain in detail language competition of migrating human communities, but it certainly shows that languages of settlers are favored over nomadic ones.

  4. Theoretical Implementations of Various Mobile Applications Used in English Language Learning

    ERIC Educational Resources Information Center

    Small, Melissa

    2014-01-01

    This review of the theoretical framework for Mastery Learning Theory and Sense of Community theories is provided in conjunction with a review of the literature for mobile technology in relation to language learning. Although empirical research is minimal for mobile phone technology as an aid for language learning, the empirical research that…

  5. Mobile-Assisted Vocabulary Learning: A Review Study

    ERIC Educational Resources Information Center

    Afzali, Parichehr; Shabani, Somayeh; Basir, Zohreh; Ramazani, Mohammad

    2017-01-01

    Mobile phones are becoming more acceptable toolkits to learn languages. One aspect of English language which has been subject to investigation in mobile-assisted language learning (MALL) is vocabulary. This study reviewed some of the studies conducted in various contexts on the effect of MALL on vocabulary learning. We investigated some of the…

  6. Collaborative Learning: Group Interaction in an Intelligent Mobile-Assisted Multiple Language Learning System

    ERIC Educational Resources Information Center

    Troussas, Christos; Virvou, Maria; Alepis, Efthimios

    2014-01-01

    This paper proposes a student-oriented approach tailored to effective collaboration between students using mobile phones for language learning within the life cycle of an intelligent tutoring system. For this reason, in this research, a prototype mobile application has been developed for multiple language learning that incorporates intelligence in…

  7. Exploring Mobile Apps for English Language Teaching and Learning

    ERIC Educational Resources Information Center

    Zou, Bin; Li, Jiaying

    2015-01-01

    Many recent studies have shown that mobile learning can provide potential possibilities for foreign language learners to practice language skills on their smart mobile phones and tablet PCs (e.g. Chang & Hsu, 2011; Egbert, Akasha, Huff, & Lee, 2011; Hoven & Palalas, 2011; Stockwell, 2010). A number of apps have been created and used…

  8. World Language Students' Ethnographic Investigations of Culture through Mobile Devices

    ERIC Educational Resources Information Center

    Tuttle, Harry G.; Tuttle, Lori A.

    2017-01-01

    World language teachers can transform how their students learn culture through the use of mobile devices. When world language students use their mobile devices to access authentic current culture, they go from being passive receivers of culture to active cultural investigators. These students go from learning thin surface culture to exploring…

  9. SWARMS: Scalable sWarms of Autonomous Robots and Mobile Sensors

    DTIC Science & Technology

    2013-03-18

    Pasqualetti, Antonio Franchi , Francesco Bullo. On optimal cooperative patrolling, 2010 49th IEEE Conference on Decision and Control (CDC). 2010/12/15 00...exhibits “ global stability” Provided a complete convergence proof for the adaptive version of the range only station keeping problem. Graph Theoretic

  10. PASCAL/48 reference manual

    NASA Technical Reports Server (NTRS)

    Knight, J. C.; Hamm, R. W.

    1984-01-01

    PASCAL/48 is a programming language for the Intel MCS-48 series of microcomputers. In particular, it can be used with the Intel 8748. It is designed to allow the programmer to control most of the instructions being generated and the allocation of storage. The language can be used instead of ASSEMBLY language in most applications while allowing the user the necessary degree of control over hardware resources. Although it is called PASCAL/48, the language differs in many ways from PASCAL. The program structure and statements of the two languages are similar, but the expression mechanism and data types are different. The PASCAL/48 cross-compiler is written in PASCAL and runs on the CDC CYBER NOS system. It generates object code in Intel hexadecimal format that can be used to program the MCS-48 series of microcomputers. This reference manual defines the language, describes the predeclared procedures, lists error messages, illustrates use, and includes language syntax diagrams.

  11. Mobile Language Learning: The Medium Is ^Not The Message

    ERIC Educational Resources Information Center

    Lotherington, Heather

    2018-01-01

    This paper repositions McLuhan's (1964/1965) extension theory of technology in the context of "mobile (-assisted) language learning" (MALL), and explores whether and how the medium (i.e., the mobile device) impacts the message (i.e., the target language) and the means by which it is taught in MALL. A survey of recommended commercial MALL…

  12. Mobile-Assisted Language Learning: Student Attitudes to Using Smartphones to Learn English Vocabulary

    ERIC Educational Resources Information Center

    Davie, Neil; Hilber, Tobias

    2015-01-01

    This project examines mobile-assisted language learning (MALL) and in particular the attitudes of undergraduate engineering students at the South Westphalia University of Applied Sciences towards the use of the smartphone app Quizlet to learn English vocabulary. Initial data on attitudes to learning languages and to the use of mobile devices to do…

  13. Creativity and Mobile Language Learning Using LingoBee

    ERIC Educational Resources Information Center

    Petersen, Sobah Abbas; Procter-Legg, Emma; Cacchione, Annamaria

    2013-01-01

    In this paper, the authors explore the ideas of mobility and creativity through the use of LingoBee, a mobile app for situated language learning. LingoBee is based on ideas from crowd-sourcing and social networking to support language learners. Learners are able to create their own content and share it with other learners through a repository. The…

  14. Why and How Do Distance Learners Use Mobile Devices for Language Learning?

    ERIC Educational Resources Information Center

    Demouy, Valérie; Jones, Ann; Kan, Qian; Kukulska-Hulme, Agnes; Eardley, Annie

    2016-01-01

    Most of the literature on mobile language learning is located in classroom contexts, and often concerns the use of resources developed by teachers or researchers. However, we also need to understand learner initiated practices, in informal as well as formal settings, where mobile language learners are increasingly using digital resources. In this…

  15. Impact of Contextuality on Mobile Learning Acceptance: An Empirical Study Based on a Language Learning App

    ERIC Educational Resources Information Center

    Böhm, Stephan; Constantine, Georges Philip

    2016-01-01

    Purpose: This paper aims to focus on contextualized features for mobile language learning apps. The scope of this paper is to explore students' perceptions of contextualized mobile language learning. Design/Methodology/Approach: An extended Technology Acceptance Model was developed to analyze the effect of contextual app features on students'…

  16. Toward Mobile Assisted Language Learning Apps for Professionals That Integrate Learning into the Daily Routine

    ERIC Educational Resources Information Center

    Pareja-Lora, Antonio; Arús-Hita, Jorge; Read, Timothy; Rodríguez-Arancón, Pilar; Calle-Martínez, Cristina; Pomposo, Lourdes; Martín-Monje, Elena; Bárcena, Elena

    2013-01-01

    In this short paper, we present some initial work on Mobile Assisted Language Learning (MALL) undertaken by the ATLAS research group. ATLAS embraced this multidisciplinary field cutting across Mobile Learning and Computer Assisted Language Learning (CALL) as a natural step in their quest to find learning formulas for professional English that…

  17. 78 FR 39295 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... standardized and readily accessible source of data, the CDC EHDI program developed a survey to be used annually... Detection and Intervention (EHDI) programs with quality improvement activities and provide information that... or the current system from the Directors of Speech and Language Programs in State Health and Welfare...

  18. 77 FR 75936 - Control of Communicable Diseases: Interstate; Scope and Definitions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... add more current medical terminology where appropriate. HHS/CDC has determined that this NPRM is... proposing to update the definitions for interstate quarantine regulations to reflect modern terminology and..., under section 70.1, to reflect modern terminology and plain language commonly used by private sector...

  19. A Typology of Tasks for Mobile-Assisted Language Learning: Recommendations from a Small-Scale Needs Analysis

    ERIC Educational Resources Information Center

    Park, Moonyoung; Slater, Tammy

    2014-01-01

    In response to the research priorities of members of TESOL (Teachers of English to Speakers of Other Languages), this study investigated language learners' realworld tasks in mobile-assisted language learning (MALL) to inform the future development of pedagogic tasks for academic English as a second language (ESL) courses. The data included…

  20. Integrating Mobile Technologies into Very Young Second Language Learners' Curriculum

    ERIC Educational Resources Information Center

    Sadykova, Gulnara; Gimaletdinova, Gulnara; Khalitova, Liliia; Kayumova, Albina

    2016-01-01

    This report is based on an exploratory case study of a private multilingual preschool language program that integrated a Mobile-Assisted Language Learning (MALL) project into the curriculum of five/six year-old children whose native language(s) is/are Russian and/or Tatar. The purpose of the study was to reveal teachers' and parents' perceptions…

  1. Impact of Contextuality on Mobile Learning Acceptance: An Empirical Study Based on a Language Learning App

    ERIC Educational Resources Information Center

    Böhm, Stephan; Constantine, Georges Philip

    2015-01-01

    The mobility of both the device and the learner will determine how mobile learning takes place. Mobile learning offers new educational opportunities that allow for autonomous, personalized and context aware learning. This paper focuses on contextualized features for mobile language learning apps. Context-awareness is seen as a particularly…

  2. Mobile Technologies as Boundary Objects in the Hands of Student Teachers of Languages inside and outside the University

    ERIC Educational Resources Information Center

    Gajek, Elzbieta

    2016-01-01

    This paper presents the use of mobile devices by students of linguistics, future foreign language teachers, outside the university and in-campus, and their vision of the potential usefulness of such devices for language learning at tertiary level. As various characteristics of mobile devices influence their usability, users select a device to fit…

  3. Leveraging Mobile Games for Place-Based Language Learning

    ERIC Educational Resources Information Center

    Holden, Christopher L.; Sykes, Julie M.

    2011-01-01

    This paper builds on the emerging body of research aimed at exploring the educational potential of mobile technologies, specifically, how to leverage place-based, augmented reality mobile games for language learning. Mentira is the first place-based, augmented reality mobile game for learning Spanish in a local neighborhood in the Southwestern…

  4. Perspectives of Introduction of the Mobile-Assisted Language Learning (MALL) Technology

    ERIC Educational Resources Information Center

    Wagner, Monica-Nataliia Laurensovna; Donskaya, Maryana Vladimirovna; Kupriyanova, Milana Evgenievna; Ovezova, Umeda Akparovna

    2016-01-01

    Present article addresses methodological and technical (instrumental) aspects of creation and implementation of mobile-assisted learning, which is oriented to the process of foreign languages learning. We provide the interpretation of the main definitions of mobile-assisted learning, as well as propose recommendations for using mobile devices in…

  5. Mobile Immersion: An Experiment Using Mobile Instant Messenger to Support Second-Language Learning

    ERIC Educational Resources Information Center

    Lai, Arthur

    2016-01-01

    Immersion has been an acclaimed approach for second-language acquisition, but is not available to most students. The idea of this study was to create a mobile immersion environment on a smartphone using a mobile instant messenger, WhatsApp™. Forty-five Form-1 (7th grade) students divided into the Mobile Group and Control Group participated in a…

  6. Computer program for prediction of capture maneuver probability for an on-off reaction controlled upper stage

    NASA Technical Reports Server (NTRS)

    Knauber, R. N.

    1982-01-01

    A FORTRAN coded computer program which computes the capture transient of a launch vehicle upper stage at the ignition and/or separation event is presented. It is for a single degree-of-freedom on-off reaction jet attitude control system. The Monte Carlo method is used to determine the statistical value of key parameters at the outcome of the event. Aerodynamic and booster induced disturbances, vehicle and control system characteristics, and initial conditions are treated as random variables. By appropriate selection of input data pitch, yaw and roll axes can be analyzed. Transient response of a single deterministic case can be computed. The program is currently set up on a CDC CYBER 175 computer system but is compatible with ANSI FORTRAN computer language. This routine has been used over the past fifteen (15) years for the SCOUT Launch Vehicle and has been run on RECOMP III, IBM 7090, IBM 360/370, CDC6600 and CDC CYBER 175 computers with little modification.

  7. Opinions and Attitudes of Prospective Teachers for the Use of Mobile Phones in Foreign Language Learning

    ERIC Educational Resources Information Center

    Cakir, Ismail

    2015-01-01

    The aim of this study is to explore the current use of mobile phones in a foreign language teaching context where English is used as the medium of instruction by prospective teachers. To this end, it presents the views of prospective English teachers on utilizing the mobile phone as an instructional tool for foreign language learning purposes in…

  8. Mobilities of Language and Literacy Ideologies: Dual Language Graduates' Bilingualism and Biliteracy

    ERIC Educational Resources Information Center

    Granados, Nadia R.

    2017-01-01

    Using qualitative methodology, this research examines how graduates of a K-5 dual language immersion program have experienced multiple and competing social, cultural, institutional, and political forces at play in complex processes that ultimately affect one's mobilities of language, literacy, and learning. These students have now grown into…

  9. A Context-Aware Solution in Mobile Language Learning

    ERIC Educational Resources Information Center

    Fatahipour, Majid; Ghaseminajm, Mahnaz

    2014-01-01

    Despite obvious benefits, some challenges exist in the way of sustainable utilization of mobile phone technology for language learning tasks. This paper shows how these challenges can be better addressed in the light of recent advancements in mobile phone technology, like context aware mobile learning, informed with a sound pedagogical basis for…

  10. Moving Bravely towards Mobile Learning: Iranian Students' Use of Mobile Devices for Learning English as a Foreign Language

    ERIC Educational Resources Information Center

    Dashtestani, Reza

    2016-01-01

    In recent years, students have shown growing interest in mobile learning and the use of mobile devices for learning English as a foreign language (EFL). However, it appears that further research needs to be undertaken to identify students' use of mobile devices and their attitudes towards them, especially in developing countries. To achieve this…

  11. 77 FR 50512 - Announcement of Requirements and Registration for Dare To Prepare (D2P) Challenge

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... improve nationwide preparedness awareness and readiness. HHS/CDC will use social media outlets (blog... Process for Participants This challenge will be internet-based using a variety of social media platforms...) containing profane language, violence or weapons, sexually explicit content, or personal attacks on people or...

  12. Twenty Ideas for Using Mobile Phones in the Language Classroom

    ERIC Educational Resources Information Center

    Reinders, Hayo

    2010-01-01

    These days it seems mobile phones are used everywhere by everyone, which leads to the obvious question: How can mobile phone technology support learning in the second language classroom? The answer is "in a number of ways" because mobile phones come with ever-increasing functions that most students are adept at using. In this article the author…

  13. User Experience of a Mobile Speaking Application with Automatic Speech Recognition for EFL Learning

    ERIC Educational Resources Information Center

    Ahn, Tae youn; Lee, Sangmin-Michelle

    2016-01-01

    With the spread of mobile devices, mobile phones have enormous potential regarding their pedagogical use in language education. The goal of this study is to analyse user experience of a mobile-based learning system that is enhanced by speech recognition technology for the improvement of EFL (English as a foreign language) learners' speaking…

  14. Mobile Language Study

    DTIC Science & Technology

    2003-08-18

    Language Study 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5d. TASK NUMBER 6. AUTHOR(S) Professor Mads Dam, Pablo Giambiagi 5e...Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39-18 SPC 01-4025 Mobile Language Study Final...smart card applications. Smart cards can be programmed using general-purpose languages ; but because of their limited resources, smart card programs

  15. Language Tasks Using Touch Screen and Mobile Technologies: Reconceptualizing Task-Based CALL for Young Language Learners

    ERIC Educational Resources Information Center

    Pellerin, Martine

    2014-01-01

    This article examines how the use of mobile technologies (iPods and tablets) in language classrooms contributes to redesigning task-based approaches for young language learners. The article is based on a collaborative action research (CAR) project in Early French Immersion classrooms in the province of Alberta, Canada. The data collection included…

  16. My Personal Mobile Language Learning Environment: An Exploration and Classification of Language Learning Possibilities Using the iPhone

    ERIC Educational Resources Information Center

    Perifanou, Maria A.

    2011-01-01

    Mobile devices can motivate learners through moving language learning from predominantly classroom-based contexts into contexts that are free from time and space. The increasing development of new applications can offer valuable support to the language learning process and can provide a basis for a new self regulated and personal approach to…

  17. The Impacts of Distance Interactivity on Learners' Achievements in Online Mobile Language Learning: Social Software and Participatory Learning

    ERIC Educational Resources Information Center

    Mellati, Morteza; Khademi, Marzieh

    2015-01-01

    The expansion of technological applications such as computers and mobile phones in the past three decades has impacted our life from different perspectives. Language teaching is no exception and like other fields of study, language teaching has also influenced by new language teaching sources and software. More recently, there has been a…

  18. The Use of Modular Computer-Based Lessons in a Modification of the Classical Introductory Course in Organic Chemistry.

    ERIC Educational Resources Information Center

    Stotter, Philip L.; Culp, George H.

    An experimental course in organic chemistry utilized computer-assisted instructional (CAI) techniques. The CAI lessons provided tutorial drill and practice and simulated experiments and reactions. The Conversational Language for Instruction and Computing was used, along with a CDC 6400-6600 system; students scheduled and completed the lessons at…

  19. A Pox on Pithy Prescriptions. CDC Technical Report No. 9.

    ERIC Educational Resources Information Center

    Steinberg, Erwin R.

    Intended for writing teachers, this paper shows how "pithy prescriptions" for writing, such as "use definite, specific, concrete language," can be misleading or wrong. To support this thesis, the paper examines a technical writing book advocating short sentences and finds that it has sentences averaging 27.8 words in one section and 30.18 in…

  20. A Digital Simulation Program for Health Science Students to Follow Drug Levels in the Body

    ERIC Educational Resources Information Center

    Stavchansky, Salomon; And Others

    1977-01-01

    The Rayetheon Scientific Simulation Language (RSSL) program, an easily-used simulation on the CDC/6600 computer at the University of Texas at Austin, offers a simple method of solving differential equations on a digital computer. It is used by undergraduate biopharmaceutics-pharmacokinetics students and graduate students in all areas. (Author/LBH)

  1. Teacher Perspectives on the Integration of Mobile-Assisted Language Learning

    ERIC Educational Resources Information Center

    Grimshaw, Jennica; Cardoso, Walcir; Collins, Laura

    2017-01-01

    Mobile-Assisted Language Learning (MALL) provides second language (L2) learners and teachers with resources to enhance the learning experience, including its anytime, anywhere accessibility (Traxler, 2007). However, factors such as lack of confidence with technology (Son, 2014) and time limitations (Godwin-Jones, 2015) may prevent teachers from…

  2. Wisconsin Youth Risk Behaviors: 1993 Survey Results. Bulletin No. 94305.

    ERIC Educational Resources Information Center

    Fernan, Steven A.; And Others

    How can state leaders mobilize to meet the health and safety needs of its school-age children? To understand more about children's health, the Wisconsin Department of Public Instruction (DPI) has surveyed Wisconsin students. In 1993 the DPI and the U.S. Centers for Disease Control (CDC) joined forces to conduct the Youth Risk Behavior Survey.…

  3. Review of Research on Mobile Language Learning in Authentic Environments

    ERIC Educational Resources Information Center

    Shadiev, Rustam; Hwang, Wu-Yuin; Huang, Yueh-Min

    2017-01-01

    We reviewed literature from 2007 to 2016 (March) on mobile language learning in authentic environments. We aimed to understand publications' trend, research focus, technology used, methodology, and current issues. Our results showed that there was increasing trend in the publications. Students' perceptions towards mobile learning technologies and…

  4. Language Learning Podcasts and Learners' Belief Change

    ERIC Educational Resources Information Center

    Basaran, Süleyman; Cabaroglu, Nese

    2014-01-01

    The ubiquitous use of Internet-based mobile devices in educational contexts means that mobile learning has become a plausible alternative to or a good complement for conventional classroom-based teaching. However, there is a lack of research that explores and defines the characteristics and effects of mobile language learning (LL) through language…

  5. Mobile-Assisted Grammar Exercises: Effects on Self-Editing in L2 Writing

    ERIC Educational Resources Information Center

    Li, Zhi; Hegelheimer, Volker

    2013-01-01

    In this paper, we report on the development and implementation of a web-based mobile application, "Grammar Clinic," for an ESL writing class. Drawing on insights from the interactionist approach to Second Language Acquisition (SLA), the Noticing Hypothesis, and mobile-assisted language learning (MALL), "Grammar Clinic" was…

  6. Learning Foreign Languages Using Mobile Applications

    ERIC Educational Resources Information Center

    Gafni, Ruti; Achituv, Dafni Biran; Rachmani, Gila Joyce

    2017-01-01

    Aim/Purpose: This study examines how the use of a Mobile Assisted Language Learning (MALL) application influences the learners' attitudes towards the process of learning, and more specifically in voluntary and mandatory environments. Background: Mobile devices and applications, which have become an integral part of our lives, are used for…

  7. Effects of Short-Term Memory and Content Representation Type on Mobile Language Learning

    ERIC Educational Resources Information Center

    Chen, Nian-Shing; Hsieh, Sheng-Wen; Kinshuk

    2008-01-01

    Due to the rapid advancements in mobile communication and wireless technologies, many researchers and educators have started to believe that these emerging technologies can be leveraged to support formal and informal learning opportunities. Mobile language learning can be effectively implemented by delivering learning content through mobile…

  8. Gender Differences in Mobile Phone Usage for Language Learning, Attitude, and Performance

    ERIC Educational Resources Information Center

    Hilao, Marites Piguing; Wichadee, Saovapa

    2017-01-01

    Mobile phone technology that has a huge impact on students' lives in the digital age may offer a new type of learning. The use of effective tool to support learning can be affected by the factor of gender. The current research compared how male and female students perceived mobile phones as a language learning tool, used mobile phones to learn…

  9. Infectious disease and dermatologic conditions in evacuees and rescue workers after Hurricane Katrina--multiple states, August-September, 2005.

    PubMed

    2005-09-30

    On August 29, 2005, Hurricane Katrina struck states along the Gulf Coast of the United States. In the days after the hurricane struck, approximately 750 evacuation centers were established in at least 18 states to accommodate more than 200,000 evacuees. State and local health departments, with assistance from CDC, initiated enhanced infectious disease surveillance and outbreak response activities, implemented by teams of public health and rescue workers, including military personnel. Outbreak monitoring included direct reporting of conditions of public health significance to public health agencies; daily contact between CDC and local public health officials; canvassing of reports from CDC, public health departments, and news media for potential infectious disease outbreaks; and investigation of reports of infectious disease with outbreak potential. This report summarizes infectious disease and dermatologic conditions reported during the first 3 weeks after the hurricane, before effective local surveillance was fully implemented. One outbreak of norovirus was reported among evacuees in Texas; no other outbreaks requiring unusual mobilization of public health resources were reported among evacuees or rescue workers.

  10. Common Problems of Mobile Applications for Foreign Language Testing

    ERIC Educational Resources Information Center

    Garcia Laborda, Jesus; Magal-Royo, Teresa; Lopez, Jose Luis Gimenez

    2011-01-01

    As the use of mobile learning educational applications has become more common anywhere in the world, new concerns have appeared in the classroom, human interaction in software engineering and ergonomics. new tests of foreign languages for a number of purposes have become more and more common recently. However, studies interrelating language tests…

  11. An Investigation of Preservice English Teachers' Perceptions of Mobile Assisted Language Learning

    ERIC Educational Resources Information Center

    Oz, Huseyin

    2015-01-01

    This study aimed to investigate preservice English as a foreign language (EFL) teachers' perceptions about mobile assisted language learning (MALL) and find out whether their perceptions differed by gender, grade level and grade point average (GPA). The study also sought to determine whether gender, grade level and GPA variables would predict…

  12. Facilitating Teachers' Reuse of Mobile Assisted Language Learning Resources Using Educational Metadata

    ERIC Educational Resources Information Center

    Zervas, Panagiotis; Sampson, Demetrios G.

    2014-01-01

    Mobile assisted language learning (MALL) and open access repositories for language learning resources are both topics that have attracted the interest of researchers and practitioners in technology enhanced learning (TeL). Yet, there is limited experimental evidence about possible factors that can influence and potentially enhance reuse of MALL…

  13. Surveying and Modeling Students' Motivation and Learning Strategies for Mobile-Assisted Seamless Chinese Language Learning

    ERIC Educational Resources Information Center

    Chai, Ching Sing; Wong, Lung-Hsiang; King, Ronnel B.

    2016-01-01

    Seamless language learning promises to be an effective learning approach that addresses the limitations of classroom-only language learning. It leverages mobile technologies to facilitate holistic and perpetual learning experiences that bridge different locations, times, technologies or social settings. Despite the emergence of studies on seamless…

  14. Systematising the Field of Mobile Assisted Language Learning

    ERIC Educational Resources Information Center

    Viberg, Olga; Grönlund, Åke

    2013-01-01

    This study provides a systematic review of mobile assisted language (MALL) research within the specific area of second language acquisition (SLA) during the period of 2005-2012 in terms of research approaches, theories and methods, technology, and the linguistic knowledge and skills' results. The findings show a shift from the prevailing SMS-based…

  15. Methodologies of Bilingual Instruction in Literacy Education. Project Mobile, 1988-89. OREA Report.

    ERIC Educational Resources Information Center

    Berney, Tomi D.; Plotkin, Donna

    In its second year, Methodologies of Bilingual Instruction in Literacy Education (Project MOBILE) provided 373 students of limited English proficiency, native speakers of Spanish and Haitian Creole, with supplementary English as a Second Language (ESL), native language arts (NLA), and content-area instruction. Project MOBILE stressed the…

  16. The Potential for Mobile Learning in English as a Foreign Language and Nursing Education

    ERIC Educational Resources Information Center

    Davison, C. J.

    2013-01-01

    This paper investigates the application of mobile technologies to support learning in a specific field: nursing education for English as a Foreign Language (EFL) learners, which is the context of the author's institution. Using a qualitative meta-synthesis methodology, factors from published literature that facilitates success in mobile learning…

  17. Improving the English-Speaking Skills of Young Learners through Mobile Social Networking

    ERIC Educational Resources Information Center

    Sun, Zhong; Lin, Chin-Hsi; You, Jiaxin; Shen, Hai jiao; Qi, Song; Luo, Liming

    2017-01-01

    Most students of English as a foreign language (EFL) lack sufficient opportunities to practice their English-speaking skills. However, the recent development of social-networking sites (SNSs) and mobile learning, and especially mobile-assisted language learning, represents new opportunities for these learners to practice speaking English in a…

  18. Mobile Learning: A Powerful Tool for Ubiquitous Language Learning

    ERIC Educational Resources Information Center

    Gomes, Nelson; Lopes, Sérgio; Araújo, Sílvia

    2016-01-01

    Mobile devices (smartphones, tablets, e-readers, etc.) have come to be used as tools for mobile learning. Several studies support the integration of such technological devices with learning, particularly with language learning. In this paper, we wish to present an Android app designed for the teaching and learning of Portuguese as a foreign…

  19. Knowledge, Attitudes, and Practices Regarding Avian Influenza A (H7N9) Among Mobile Phone Users: A Survey in Zhejiang Province, China.

    PubMed

    Gu, Hua; Jiang, Zhenggang; Chen, Bin; Zhang, Jueman Mandy; Wang, Zhengting; Wang, Xinyi; Cai, Jian; Chen, Yongdi; Zheng, Dawei; Jiang, Jianmin

    2015-02-04

    Understanding people's knowledge, attitudes, and practices (KAP) regarding a new infectious disease is crucial to the prevention and control of it. Human infection with avian influenza A (H7N9) was first identified on March 31, 2013 in China. Out of the total number of 134 cases confirmed from March to September 2013 in China, Zhejiang Province saw the greatest number (46 cases). This study employed a mobile Internet survey to assess KAP regarding H7N9 among mobile phone users in Zhejiang Province. This study intended to examine KAP by region and the association between sociodemographic variables and KAP. An anonymous questionnaire was designed by Zhejiang Provincial Center for Disease Control and Prevention (CDC). A cross-sectional survey was executed through a mobile Internet application platform of China Unicom in 5 regions in Zhejiang Province. Stratified and clustered sampling methods were applied and mobile phone users were invited to participate in the study voluntarily. A total of 9582 eligible mobile phone users participated in the survey with a response rate of 1.92% (9582/5,000,000). A total of 9105 valid responses (95.02%) were included for statistical analysis. Generally, more than three-quarters of the participants had some basic knowledge of H7N9 and held the attitude recommended by the Zhejiang CDC toward eating cooked poultry (77.55%, 7061/9105) and visiting a hospital at the occurrence of symptoms (78.51%, 7148/9105). Approximately half of the participants worried about contracting H7N9, and took preventive practices recommended by the Zhejiang CDC. But only 14.29% (1301/9105) of participants kept eating cooked poultry as usual. Although worry about H7N9 infection did not differ by region, Hangzhou saw the largest proportion of participants with knowledge of H7N9, which was probably because Hangzhou had the greatest number of H7N9 cases. KAP varied by some sociodemographic variables. Female participants were more likely to know about symptoms of H7N9 (OR 1.32, 95% CI 1.08-1.61), to worry about contracting it (OR 1.15, 95% CI 1.04-1.27), and to report their lives being influenced by it (OR 1.27, 95% CI 1.15-1.41). They were also more likely to take the recommended precautions. Male participants and younger participants were less likely to comply with advocated protective practices. The results suggest that health education should be customized depending on sociodemographic variables to achieve more effective behavioral outcomes.

  20. Selecting the Best Mobile Information Service with Natural Language User Input

    NASA Astrophysics Data System (ADS)

    Feng, Qiangze; Qi, Hongwei; Fukushima, Toshikazu

    Information services accessed via mobile phones provide information directly relevant to subscribers’ daily lives and are an area of dynamic market growth worldwide. Although many information services are currently offered by mobile operators, many of the existing solutions require a unique gateway for each service, and it is inconvenient for users to have to remember a large number of such gateways. Furthermore, the Short Message Service (SMS) is very popular in China and Chinese users would prefer to access these services in natural language via SMS. This chapter describes a Natural Language Based Service Selection System (NL3S) for use with a large number of mobile information services. The system can accept user queries in natural language and navigate it to the required service. Since it is difficult for existing methods to achieve high accuracy and high coverage and anticipate which other services a user might want to query, the NL3S is developed based on a Multi-service Ontology (MO) and Multi-service Query Language (MQL). The MO and MQL provide semantic and linguistic knowledge, respectively, to facilitate service selection for a user query and to provide adaptive service recommendations. Experiments show that the NL3S can achieve 75-95% accuracies and 85-95% satisfactions for processing various styles of natural language queries. A trial involving navigation of 30 different mobile services shows that the NL3S can provide a viable commercial solution for mobile operators.

  1. Using Mobile Technology to Encourage Mathematical Communication in Maori-Medium Pangarau Classrooms

    ERIC Educational Resources Information Center

    Allen, Piata

    2017-01-01

    Maori-medium pangarau classrooms occupy a unique space within the mathematics education landscape. The language of instruction is an endangered minority language and many teachers and learners in Maori-medium pangarau classrooms are second language (L2) learners of te reo Maori. Mobile technology could be used in Maori-medium pangarau classrooms…

  2. LingoBee and Social Media: Mobile Language Learners as Social Networkers

    ERIC Educational Resources Information Center

    Procter-Legg, Emma; Cacchione, Annamaria; Petersen, Sobah Abbas

    2012-01-01

    This paper presents language learners as social networkers and describes and discusses the types of users that can be identified by analysing the content created by them using a situated mobile language learning app, LingoBee, based on the idea of crowd sourcing. Borrowing ideas from other studies conducted on social network users, we can identify…

  3. On the Spot: Using Mobile Devices for Listening and Speaking Practice on a French Language Programme

    ERIC Educational Resources Information Center

    Demouy, Valerie; Kukulska-Hulme, Agnes

    2010-01-01

    This paper presents and discusses the initial findings of a mobile language learning project undertaken in the context of an undergraduate distance-learning French language programme at The Open University (UK). The overall objective of the project was to investigate students' experiences when using their own portable devices for additional…

  4. Mobile Sign Language Learning Outside the Classroom

    ERIC Educational Resources Information Center

    Weaver, Kimberly A.; Starner, Thad

    2012-01-01

    The majority of deaf children in the United States are born to hearing parents with limited prior exposure to American Sign Language (ASL). Our research involves creating and validating a mobile language tool called SMARTSign. The goal is to help hearing parents learn ASL in a way that fits seamlessly into their daily routine. (Contains 3 figures.)

  5. Mobile Technology in Second Language Classrooms: Insights into Its Uses, Pedagogical Implications, and Teacher Beliefs

    ERIC Educational Resources Information Center

    Van Praag, Benjamin; Sanchez, Hugo Santiago

    2015-01-01

    Adopting a multiple-case, multiple-method design, this study investigates mobile technology use in the practices of three experienced second language teachers. The findings, based on an analysis of the teachers' rationales, stated beliefs and classroom actions, show that the teachers tend to prohibit or reluctantly tolerate mobile device usage,…

  6. Mobile-Assisted Language Learning Community and Culture in French-Speaking Belgium: The Teachers' Perspective

    ERIC Educational Resources Information Center

    Van de Vyver, Julie

    2016-01-01

    This paper focuses on the perceptions and uses of mobile technologies by 118 Belgian teachers in foreign language teaching and learning in secondary education. The purpose of the study is to analyze the teachers' attitudes towards the use of mobile technologies in- and outside the classroom via an online questionnaire. The preliminary findings…

  7. Investigating Mobile-Assisted Oral Feedback in Teaching Chinese as a Second Language

    ERIC Educational Resources Information Center

    Xu, Qi; Peng, Hongying

    2017-01-01

    This article reports on an exploratory study investigating mobile-assisted oral feedback in teaching Chinese as a second language (CSL). It is aimed at exploring the characteristics of mobile-assisted feedback on oral production with the smartphone social communication app WeChat as a case in point and examining learners' perceptions of…

  8. Analysis of Documents Published in Scopus Database on Foreign Language Learning through Mobile Learning: A Content Analysis

    ERIC Educational Resources Information Center

    Uzunboylu, Huseyin; Genc, Zeynep

    2017-01-01

    The purpose of this study is to determine the recent trends in foreign language learning through mobile learning. The study was conducted employing document analysis and related content analysis among the qualitative research methodology. Through the search conducted on Scopus database with the key words "mobile learning and foreign language…

  9. Integration and Language Learning of Newly Arrived Migrants Using Mobile Technology

    ERIC Educational Resources Information Center

    Bradley, Linda; Lindström, Nataliya Berbyuk; Hashemi, Sylvana Sofkova

    2017-01-01

    The purpose of this study is to investigate the mobile activities newly arrived migrants are engaged in when learning the Swedish language and about Swedish culture and society. Further, the study also explores the use of a mobile application (app) provided to the newly arrived migrants to use for pronunciation practice. The study involved 38…

  10. Motivating PAU Language Testing Candidates through Mobile Technology

    ERIC Educational Resources Information Center

    Gimenez Lopez, Jose Luis; Garcia Laborda, Jesus; Magal Royo, M. Teresa

    2011-01-01

    Mobile learning permits combining the most motivating elements of online learning. When becoming a supplement to face-to-face education, it is likely to become a most motivating achievement in e-learning. Up to now, little interest and work has been posed in proposing mobile learning as a supporting element for language testing. In this paper, we…

  11. A Personalized Recommendation-Based Mobile Learning Approach to Improving the Reading Performance of EFL Students

    ERIC Educational Resources Information Center

    Hsu, Ching-Kun; Hwang, Gwo-Jen; Chang, Chih-Kai

    2013-01-01

    In this paper, a personalized recommendation-based mobile language learning approach is proposed. A mobile learning system has been developed based on the approach by providing a reading material recommendation mechanism for guiding EFL (English as Foreign Language) students to read articles that match their preferences and knowledge levels, and a…

  12. Communicable disease control in China: From Mao to now

    PubMed Central

    Hipgrave, David

    2011-01-01

    China’s progress on communicable disease control (CDC) in the 30 years after establishment of the People’s Republic in 1949 is widely regarded as remarkable. Life expectancy soared by around 30 years, infant mortality plummeted and smallpox, sexually transmitted diseases and many other infections were either eliminated or decreased massively in incidence, largely as a result of CDC. By the mid-1970s, China was already undergoing the epidemiologic transition, years ahead of other nations of similar economic status. These early successes can be attributed to population mobilization, mass campaigns and a focus on sanitation, hygiene, clean water and clean delivery, and occurred despite political instability and slow economic progress. The 10-year Cultural Revolution from 1966 brought many hardships, but also clinical care and continuing public health programs to the masses through community-funded medical schemes and the establishment of community-based health workers. These people-focused approaches broke down with China’s market reforms from 1980. Village doctors turned to private practice as community funding ceased, and the attention paid to rural public health declined. CDC relied on vertical programs, some of them successful (such as elimination of lymphatic filariasis and child immunisation), but others (such as control of schistosomiasis and tuberculosis) demonstrating only intermittent progress due to failed strategies or reliance on support by the poorest governments and health workers, who could not or would not collaborate. In addition, China’s laissez-faire approach to public health placed it at great risk, as evidenced by the outbreak in 2003 of the Severe Acute Respiratory Syndrome. Since then, major changes to disease reporting, the priority given to CDC including through major new domestic resources and reform of China’s health system offer encouragement for CDC. While decentralized funding and varying quality diagnosis, reporting and treatment of infectious diseases remain major challenges, national priority on CDC in China is high. PMID:23198121

  13. Impact of Mobile Assisted Language Learning (MALL) on EFL: A Meta-Analysis

    ERIC Educational Resources Information Center

    Taj, Imtiaz Hassan; Sulan, Norrihan Binti; Sipra, Muhammad Aslam; Ahmad, Waqar

    2016-01-01

    Mobile Assisted Language Learning (MALL) has emerged as a potential tool in the instruction of English as a foreign language (EFL). Meta-analysis of 13 studies published between year 2008 and 2015 was conducted. Four point criteria for the selection of studies for analysis is based on the year of publication, quasi-experimental design, pretest and…

  14. Technological Diversity: A Case Study into Language Learners' Mobile Technology Use Inside and Outside the Classroom

    ERIC Educational Resources Information Center

    Brick, Billy; Cervi-Wilson, Tiziana

    2015-01-01

    The speed of technological advance in the mobile phone, netbook and tablet markets has meant that learners increasingly have access to digital devices capable of enhancing their learning experience. This case study reports on how language learners, taking Italian as an option on the Institution Wide Languages Programme (IWLP) at Coventry…

  15. A Case Study on Mobile-Blended Collaborative Learning in an English as a Foreign Language (EFL) Context

    ERIC Educational Resources Information Center

    Avci, Hulya; Adiguzel, Tufan

    2017-01-01

    As learning a foreign language poses a number of challenges for the students, it has become indispensable to search for "optimal" conditions to enhance opportunities of engaging in the target language. Within this context, the Mobile-Blended Collaborative Learning model has been integrated in and out of the classroom learning in order to…

  16. Examining EFL Teachers' Technological Pedagogical Content Knowledge and the Adoption of Mobile-Assisted Language Learning: A Partial Least Square Approach

    ERIC Educational Resources Information Center

    Hsu, Liwei

    2016-01-01

    This study examines EFL (English as a foreign Language) teachers' technological pedagogical content knowledge (TPACK) and how such knowledge affects the adoption of mobile-assisted language learning (MALL). A total of 158 in-service Taiwanese English teachers were surveyed. Two frameworks were employed to examine latent constructs: TPACK and the…

  17. Is Mobile-Assisted Language Learning Really Useful? An Examination of Recall Automatization and Learner Autonomy

    ERIC Educational Resources Information Center

    Sato, Takeshi; Murase, Fumiko; Burden, Tyler

    2015-01-01

    The aim of this study is to examine the advantages of Mobile-Assisted Language Learning (MALL), especially vocabulary learning of English as a foreign or second language (L2) in terms of the two strands: automatization and learner autonomy. Previous studies articulate that technology-enhanced L2 learning could bring about some positive effects.…

  18. Struggling to Thrive: The Impact of Chinese Language Assessments on Social Mobility of Hong Kong Ethnic Minority Youth

    ERIC Educational Resources Information Center

    Loh, Elizabeth K. Y.; Tam, Loretta C. W.

    2016-01-01

    The paper explores how the policy of alternative Chinese qualifications policy affects ethnic minorities' (EM) social mobility, and how such multi-exit assessment framework affects Chinese as a second language learning and teaching in Hong Kong. Chinese language (CL) qualifications other than the Hong Kong Diploma of Secondary Education (HKDSE)…

  19. A Multi-Case Study of University Students' Language-Learning Experience Mediated by Mobile Technologies: A Socio-Cultural Perspective

    ERIC Educational Resources Information Center

    Ma, Qing

    2017-01-01

    Emerging mobile technologies can be considered a new form of social and cultural artefact that mediates people's language learning. This multi-case study investigates how mobile technologies mediate a group of Hong Kong university students' L2 learning, which serves as a lens with which to capture the personalised, unique, contextual and…

  20. Use of Mobile Testing System PeLe for Developing Language Skills

    ERIC Educational Resources Information Center

    Titova, Svetlana

    2015-01-01

    One of the objectives of this paper is to investigate the pedagogical impact of both the mobile testing system PeLe (Norway, HiST) and the enquiry-based learning approach on language skills development in the context of mobile-assisted learning. The research aims to work out a methodological framework of PeLe implementation into the language…

  1. Cardiovascular, diabetes, and cancer strips: evidences, mechanisms, and classifications

    PubMed Central

    Wu, Qing-Hua; Hu, Da-Yi

    2014-01-01

    Objectives To report and name firstly that there are cardiovascular disease (CVD), diabetes mellitus (DM) and cancers (CDC) strips; and disclose their mechanisms, classifications, and clinical significances. Study design Narrative and systematic review study and interpretive analysis. Methods Data sources and study selection: to collect and present related evidences on CDC strips from evidence-based, open-access, both Chinese- and English-language literatures in recent 10 years on clinical trials from PubMed according to keywords “CVD, DM and cancers” as well as authors’ extensive clinical experience with the treatment of more than fifty thousands of patients with CVD, diabetes and cancers over the past decades, and analyze their related mechanisms and categories which based on authors’ previous works. Data extraction: data were mainly extracted from 48 articles which are listed in the reference section of this review. Qualitative, quantitative and mixed data were included, narratively and systematically reviewed. Results With several conceptual and technical breakthrough, authors present related evidences on CDC strips, these are, CVD and DM, DM and cancers, cancers and CVD linked, respectively; And “Bad SEED” +/– “bad soil” theory or doctrine may explain this phenomenon due to “internal environmental injure, abnormal or unbalance” in human body resulting from the role of risk factors (RFs) related multi-pathways and multi-targets, which including organ & tissue (e.g., vascular-specific), cell and gene-based mechanisms. Their classifications include main strips/type B, and Branches/type A as showed by tables and figures in this article. Conclusions There are CDC strips and related mechanisms and classifications. CDC strips may help us to understand, prevent, and control related common non-communicable diseases (NCDs) as well as these high risk strips. PMID:25276377

  2. A SIMULATION OF HELICOPTER AIRCRAFT IN AN ARMED RECONNAISSANCE MODE, FOR THE CDC 1604 DIGITAL COMPUTER.

    DTIC Science & Technology

    A model is presented which is a computer simulation of a duel involving two helicopter sections, a scout and an attack section, and an armored mobile...constructed in an attempt to include the possible effects of terrain on tactics used by the combatants in the duel . The computer program, logic and model results are included. (Author)

  3. Effect of Mobile-Assisted Dialect Awareness Training on the Dialect Attitudes of Prospective English Language Teachers

    ERIC Educational Resources Information Center

    Bozoglan, Hilal; Gok, Duygu

    2017-01-01

    The purpose of this study was to investigate the impact of a mobile-assisted dialect awareness programme on the dialect attitudes of pre-service English language teachers in Turkey. The study adopted a pre-test and a post-test design including 58 first-grade pre-service English language teachers in two different classes. The experimental group…

  4. The Effect of English for Specific Purposes (ESP) Learning-Language Lab versus Mobile-Assisted Learning

    ERIC Educational Resources Information Center

    Shih, Ru-Chu

    2017-01-01

    In recent years, the rapid advancement of information technology has had a great impact on our daily life and changed the world in which we operate; in particular, mobile devices have become more portable and powerful than ever. As a result, mobile-assisted language learning (MALL) and ubiquitous learning have been widely adopted in a variety of…

  5. Use of Mobile Devices for English Language Learner Students in the United States: A Research Synthesis

    ERIC Educational Resources Information Center

    Ok, Min Wook; Ratliffe, Katherine T.

    2018-01-01

    Mobile devices have become widely used in K-12 education settings for teaching diverse students. We comprehensively reviewed 11 studies published between 2005 and 2016 that examined the use of mobile devices for teaching K-12th grade English language learner students in the United States. We also examined the methodological quality of the studies.…

  6. Learning English Speaking through Mobile-Based Role-Plays: The Exploration of a Mobile English Language Learning App Called Engage

    ERIC Educational Resources Information Center

    Yang, Bowen; Zhou, Shijun; Ju, Weijie

    2013-01-01

    Engage is a new form of mobile application that connects students studying English with teachers in real-time via their smartphones. Students receive target language through preparation dialogues, and then apply it to a role-play with a teacher. The conceptualization and development of Engage follows the user-centred design approach; and the…

  7. RecoverNow: Feasibility of a Mobile Tablet-Based Rehabilitation Intervention to Treat Post-Stroke Communication Deficits in the Acute Care Setting

    PubMed Central

    Corbett, Dale; Finestone, Hillel M.; Hatcher, Simon; Lumsden, Jim; Momoli, Franco; Shamy, Michel C. F.; Stotts, Grant; Swartz, Richard H.; Yang, Christine

    2016-01-01

    Background Approximately 40% of patients diagnosed with stroke experience some degree of aphasia. With limited health care resources, patients’ access to speech and language therapies is often delayed. We propose using mobile-platform technology to initiate early speech-language therapy in the acute care setting. For this pilot, our objective was to assess the feasibility of a tablet-based speech-language therapy for patients with communication deficits following acute stroke. Methods We enrolled consecutive patients admitted with a stroke and communication deficits with NIHSS score ≥1 on the best language and/or dysarthria parameters. We excluded patients with severe comprehension deficits where communication was not possible. Following baseline assessment by a speech-language pathologist (SLP), patients were provided with a mobile tablet programmed with individualized therapy applications based on the assessment, and instructed to use it for at least one hour per day. Our objective was to establish feasibility by measuring recruitment rate, adherence rate, retention rate, protocol deviations and acceptability. Results Over 6 months, 143 patients were admitted with a new diagnosis of stroke: 73 had communication deficits, 44 met inclusion criteria, and 30 were enrolled into RecoverNow (median age 62, 26.6% female) for a recruitment rate of 68% of eligible participants. Participants received mobile tablets at a mean 6.8 days from admission [SEM 1.6], and used them for a mean 149.8 minutes/day [SEM 19.1]. In-hospital retention rate was 97%, and 96% of patients scored the mobile tablet-based communication therapy as at least moderately convenient 3/5 or better with 5/5 being most “convenient”. Conclusions Individualized speech-language therapy delivered by mobile tablet technology is feasible in acute care. PMID:28002479

  8. RecoverNow: Feasibility of a Mobile Tablet-Based Rehabilitation Intervention to Treat Post-Stroke Communication Deficits in the Acute Care Setting.

    PubMed

    Mallet, Karen H; Shamloul, Rany M; Corbett, Dale; Finestone, Hillel M; Hatcher, Simon; Lumsden, Jim; Momoli, Franco; Shamy, Michel C F; Stotts, Grant; Swartz, Richard H; Yang, Christine; Dowlatshahi, Dar

    2016-01-01

    Approximately 40% of patients diagnosed with stroke experience some degree of aphasia. With limited health care resources, patients' access to speech and language therapies is often delayed. We propose using mobile-platform technology to initiate early speech-language therapy in the acute care setting. For this pilot, our objective was to assess the feasibility of a tablet-based speech-language therapy for patients with communication deficits following acute stroke. We enrolled consecutive patients admitted with a stroke and communication deficits with NIHSS score ≥1 on the best language and/or dysarthria parameters. We excluded patients with severe comprehension deficits where communication was not possible. Following baseline assessment by a speech-language pathologist (SLP), patients were provided with a mobile tablet programmed with individualized therapy applications based on the assessment, and instructed to use it for at least one hour per day. Our objective was to establish feasibility by measuring recruitment rate, adherence rate, retention rate, protocol deviations and acceptability. Over 6 months, 143 patients were admitted with a new diagnosis of stroke: 73 had communication deficits, 44 met inclusion criteria, and 30 were enrolled into RecoverNow (median age 62, 26.6% female) for a recruitment rate of 68% of eligible participants. Participants received mobile tablets at a mean 6.8 days from admission [SEM 1.6], and used them for a mean 149.8 minutes/day [SEM 19.1]. In-hospital retention rate was 97%, and 96% of patients scored the mobile tablet-based communication therapy as at least moderately convenient 3/5 or better with 5/5 being most "convenient". Individualized speech-language therapy delivered by mobile tablet technology is feasible in acute care.

  9. Language Issues in Mobile Program Security

    DTIC Science & Technology

    1998-01-01

    primitives for instance synchronous operations Nondeterminism and Privacy Now suppose we introduce nondeterminism via a simple concurrent language...code setting is that the only observable events are those that can be observed from within a mobile program using language primitives and any host...Possibilistic NI is given in It uses a main thread and two triggered threads each with a busy wait loop implementing a semaphore to copy every bit of

  10. From PPP and CALL/MALL to a Praxis of Task-Based Teaching and Mobile Assisted Language Use

    ERIC Educational Resources Information Center

    Jarvis, Huw

    2015-01-01

    Two of the most significant trends in TESOL (Teachers of English to Speakers of Other Languages) over the last twenty years or so are the rise of task­-based language teaching (TBLT) and the growth of technology. With TBLT there is a challenging of more traditional structure-based models of delivery, and the increased capacity and mobility of…

  11. An Exploration of the Use of Mobile Applications to Support the Learning of Chinese Characters Employed by Students of Chinese as a Foreign Language

    ERIC Educational Resources Information Center

    Mason, Amanda; Wenxin, Zhang

    2017-01-01

    At present, there are few studies which explore the learning strategies employed by students of Chinese as a Foreign Language (CFL) and even fewer that focus specifically on mobile application use. This study provides insights into how adult learners at varying levels of proficiency employ mobile apps to support their Chinese character learning.…

  12. A computer program for the calculation of thermal stratification and self-pressurization in a liquid hydrogen tank

    NASA Technical Reports Server (NTRS)

    Arnett, R. W.; Voth, R. O.

    1972-01-01

    An analysis and computer program are described for calculating the thermal stratification and the associated self-pressurization of a closed liquid hydrogen tank. FORTRAN-IV language is used and runs were made on IBM 360/65 and CDC 3600 computers. Comparisons are made between the program calculations and test results from both ground and orbital coast tests of a Centaur space vehicle.

  13. MobileASL: intelligibility of sign language video over mobile phones.

    PubMed

    Cavender, Anna; Vanam, Rahul; Barney, Dane K; Ladner, Richard E; Riskin, Eve A

    2008-01-01

    For Deaf people, access to the mobile telephone network in the United States is currently limited to text messaging, forcing communication in English as opposed to American Sign Language (ASL), the preferred language. Because ASL is a visual language, mobile video phones have the potential to give Deaf people access to real-time mobile communication in their preferred language. However, even today's best video compression techniques can not yield intelligible ASL at limited cell phone network bandwidths. Motivated by this constraint, we conducted one focus group and two user studies with members of the Deaf Community to determine the intelligibility effects of video compression techniques that exploit the visual nature of sign language. Inspired by eye tracking results that show high resolution foveal vision is maintained around the face, we studied region-of-interest encodings (where the face is encoded at higher quality) as well as reduced frame rates (where fewer, better quality, frames are displayed every second). At all bit rates studied here, participants preferred moderate quality increases in the face region, sacrificing quality in other regions. They also preferred slightly lower frame rates because they yield better quality frames for a fixed bit rate. The limited processing power of cell phones is a serious concern because a real-time video encoder and decoder will be needed. Choosing less complex settings for the encoder can reduce encoding time, but will affect video quality. We studied the intelligibility effects of this tradeoff and found that we can significantly speed up encoding time without severely affecting intelligibility. These results show promise for real-time access to the current low-bandwidth cell phone network through sign-language-specific encoding techniques.

  14. Student Mobility and Identity-Related Language Learning

    ERIC Educational Resources Information Center

    Kinginger, C.

    2015-01-01

    This paper reviews some recent studies problematizing various aspects of identity in relation to mobile students' encounters with the social interactive and pragmatic dimensions of language. The paper will examine several salient demographic categories represented in the literature: nationality, 'foreigner' status, gender, age, and…

  15. The Influence of Affordances on Learner Preferences in Mobile Language Learning

    ERIC Educational Resources Information Center

    Uther, Maria; Banks, Adrian

    2015-01-01

    This study investigates the influence of sensory and cognitive affordances on the usability of mobile devices for multimedia language learning applications. An audio-based learning application--the "Vowel Trainer" (audio-based speech app), developed by University College London was chosen, against a comparison, text and picture-based…

  16. (Re)Conceptualizing Design Approaches for Mobile Language Learning

    ERIC Educational Resources Information Center

    Hoven, Debra; Palalas, Agnieszka

    2011-01-01

    An exploratory study conducted at George Brown College in Toronto, Canada between 2007 and 2009 investigated language learning with mobile devices as an approach to augmenting ESP learning by taking learning outside the classroom into the real-world context. In common with findings at other community colleges, this study identified inadequate…

  17. Packaging printed circuit boards: A production application of interactive graphics

    NASA Technical Reports Server (NTRS)

    Perrill, W. A.

    1975-01-01

    The structure and use of an Interactive Graphics Packaging Program (IGPP), conceived to apply computer graphics to the design of packaging electronic circuits onto printed circuit boards (PCB), were described. The intent was to combine the data storage and manipulative power of the computer with the imaginative, intuitive power of a human designer. The hardware includes a CDC 6400 computer and two CDC 777 terminals with CRT screens, light pens, and keyboards. The program is written in FORTRAN 4 extended with the exception of a few functions coded in COMPASS (assembly language). The IGPP performs four major functions for the designer: (1) data input and display, (2) component placement (automatic or manual), (3) conductor path routing (automatic or manual), and (4) data output. The most complex PCB packaged to date measured 16.5 cm by 19 cm and contained 380 components, two layers of ground planes and four layers of conductors mixed with ground planes.

  18. What's the appeal? Testing public service advertisements to raise awareness about gynecologic cancer.

    PubMed

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer

    2014-06-01

    In 2013, the Centers for Disease Control and Prevention's (CDC) Inside Knowledge: Get the Facts About Gynecologic Cancer campaign tested creative concepts for English- and Spanish-language video advertisements (for use on television and the Internet) with women aged 35-64 years. Sixteen English and nine Spanish focus groups were conducted in four U.S. cities. CDC used animatics (a series of photographs edited together with a sound track) to simulate produced advertisements, without having to incur the high cost of filming and production. Advertisement concepts consistently resonating with participants featured cancer survivors, were straightforward, included information about cancer symptoms, displayed Inside Knowledge educational materials, and featured diverse women. In the general population focus groups, a primacy testing order effect was observed in which the concept tested first tended to be the most favorably received. Varying the order in which concepts were tested and considering testing order when interpreting results was critical.

  19. Collaboration Between Public Health and Law Enforcement: New Paradigms and Partnerships for Bioterrorism Planning and Response

    PubMed Central

    Cohen, Mitchell L.; Friedman, Cindy R.; Scripp, Robert M.; Watz, Craig G.

    2002-01-01

    The biological attacks with powders containing Bacillus anthracis sent through the mail during September and October 2001 led to unprecedented public health and law enforcement investigations, which involved thousands of investigators from federal, state, and local agencies. Following recognition of the first cases of anthrax in Florida in early October 2001, investigators from Centers for Disease Control and Prevention (CDC) and the Federal Bureau of Investigation (FBI) were mobilized to assist investigators from state and local public health and law enforcement agencies. Although public health and criminal investigations have been conducted in concert in the past, the response to the anthrax attacks required close collaboration because of the immediate and ongoing threat to public safety. We describe the collaborations between CDC and FBI during the investigation of the 2001 anthrax attacks and highlight the challenges and successes of public health and law enforcement collaborations in general. PMID:12396931

  20. Ebola in West Africa—CDC’s Role in Epidemic Detection, Control, and Prevention

    PubMed Central

    Damon, Inger K.

    2015-01-01

    Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency’s history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays. Efforts have included supporting incident management systems in affected countries; mobilizing partners; and strengthening laboratory, epidemiology, contact investigation, health care infection control, communication, and border screening in West Africa, Nigeria, Mali, Senegal, and the United States. All efforts were undertaken as part of national and global response activities with many partner organizations. CDC was able to support community, national, and international health and public health staff to prevent an even worse event. The Ebola virus disease epidemic highlights the need to strengthen national and international systems to detect, respond to, and prevent the spread of future health threats. PMID:26484940

  1. Computer Center CDC Libraries/NSRDC (Subprograms).

    DTIC Science & Technology

    1981-02-01

    TRANSFORM." COMM, OF THE ACM, VOL, 10, NO. 10, OCTOBER 1967. 3. SYSTEM/360 SCIENTIFIC SUBROUTINE PACKAGE, IBM TECHNICAL PUBLICATONS DEPARTMENT, 1967...VARIABLE 3) UP TO 9 DEPENDENT VARIABLES PER PLOT. FUNCTIONAL CATEGORIES: J5 LANGUAGE: FORTRAN IV USAGE COMMON /PLO/ NRUN, NPLOT, ITP .6), ITY(6), ITX(61...PLO/ NRUN - NUMBER OF THIS RUN iDEFAULT: 1) NPLOT - NUMBER OF PLOT (DEFAULT: 1 ITP - PAGE TITLE (DEFAULT: BLANK) ITY - Y TITLE (DEFAULT: BLANK) ITX - X

  2. Methodologies of Bilingual Instruction in Literacy Education. Project MOBILE, 1987-1988. OREA Report.

    ERIC Educational Resources Information Center

    Berney, Tomi D.; Plotkin, Donna

    The Methodologies of Bilingual Instruction in Literacy Education (MOBILE) project served 359 native Spanish- and Haitian Creole/French-speaking students at 2 high schools in its first year of funding. The project provided supplementary instruction in English as a Second Language (ESL), native language arts (NLA), and bilingual mathematics,…

  3. Approach to the Phenomenon of M-Learning in English Teaching

    ERIC Educational Resources Information Center

    García, Sergio; Fombona, Javier

    2015-01-01

    This research analyzes the situation of mobile devices and some specific options of support for the teaching of the English language. The features of this complex and novel phenomenon of Mobile-Assisted Language Learning (MALL) are addressed with an exploratory descriptive methodology. The article is part of a more extensive research which deals…

  4. Publishing Strategies of Young, Highly Mobile Academics: The Question of Language in the European Context

    ERIC Educational Resources Information Center

    Anderson, Laurie

    2013-01-01

    This paper examines links between publishing strategies and the academic mobility of multilingual entry-level scholars in the European context against the backdrop of European Union (EU) policies and research on academic labor market characteristics, skilled migration and scholarly publishing. An analysis of language of publication, patterns of…

  5. Mobile Seamless Technology Enhanced CSL Oral Communication

    ERIC Educational Resources Information Center

    Lan, Yu-Ju; Lin, Yen-Ting

    2016-01-01

    The current study aimed at investigating how mobile seamless technology can be used to enhance the pragmatic competence of learners of Chinese as a second language (CSL). 34 overseas CSL learners participated in this study. They were randomly assigned into two groups: the classroom group, executing language tasks in fake contexts in a traditional…

  6. Language Learning through Mobile Technologies: An Opportunity for Language Learners and Teachers

    ERIC Educational Resources Information Center

    Bachore, Mebratu Mulatu

    2015-01-01

    These days, the innovations of technologies are contributing significantly to the quality of education in spite of their limitations. Mobile technologies are rapidly attracting new users, providing increasing capacity, and allowing more sophisticated use. Since they are becoming very accessible for individuals in most parts of the world, it has a…

  7. Virtual Learning Environments on the Go: CALL Meets MALL

    ERIC Educational Resources Information Center

    Arús Hita, Jorge

    2016-01-01

    This paper presents "Eating out," a Moodle-based digital learning resource for English as a Foreign Language (EFL) teaching that can be run both on computers and mobile devices. It is argued that Mobile Assisted Language Learning (MALL) resources do not necessarily need to be specifically designed for such platforms. Rather, a carefully…

  8. Motivation Matters in Mobile Language Learning: A Brief Commentary

    ERIC Educational Resources Information Center

    Ushioda, Ema

    2013-01-01

    As highlighted in the original call for papers for this special issue, learning with mobile technologies is currently a rapidly developing area of interest for researchers, teachers, materials writers and app developers in the educational field, not least within language education. Yet to what extent is this growing interest realised and shared by…

  9. Flipped Approach to Mobile Assisted Language Learning

    ERIC Educational Resources Information Center

    Yamamoto, Junko

    2013-01-01

    There are abundant possibilities for using smart phones and tablet computers for foreign language learning. However, if there is an emphasis on memorization or on technology, language learners may not develop proficiency in their target language. Therefore, language teachers should be familiar with strategies for facilitating creative…

  10. HIV Testing Beliefs in a Predominantly Hispanic Community Health Center During the Routine HIV Testing Era: Does English Language Ability Matter?

    PubMed Central

    Amspoker, Amber B.; Lalani, Naina; Patuwo, Beverly; Kallen, Michael; Street, Richard; Viswanath, Kasisomayajula; Giordano, Thomas P.

    2013-01-01

    Abstract The Hispanic population in the U.S. carries a disproportionate burden of HIV. Despite the high prevalence of HIV, many Hispanics remain untested for HIV. The purpose of this study conducted in a predominantly Hispanic-serving community health center in a high HIV prevalence area was to understand patient beliefs of who should be tested for HIV in the routine HIV testing era. Survey participants were presented with nine populations of people that should be tested for HIV based on CDC HIV testing recommendations. Of the 90 participants (67.1% Hispanic) who answered the HIV testing beliefs question, only approximately 45% were aware that all adults and teenagers should be HIV tested. Only 30% correctly identified all nine populations of people that should be tested for HIV based on CDC HIV testing recommendations. Our study suggests that Hispanics are either unaware of or disagree with the latest CDC recommendations for routine HIV testing of all persons ages 13–64 in high HIV prevalence areas. Improving knowledge of the current HIV epidemiologic profile in the U.S. and the most recent routine HIV testing recommendations may improve HIV testing rates in Hispanic communities. PMID:23305261

  11. Methodological issues and evidence of malfeasance in research purporting to show thimerosal in vaccines is safe.

    PubMed

    Hooker, Brian; Kern, Janet; Geier, David; Haley, Boyd; Sykes, Lisa; King, Paul; Geier, Mark

    2014-01-01

    There are over 165 studies that have focused on Thimerosal, an organic-mercury (Hg) based compound, used as a preservative in many childhood vaccines, and found it to be harmful. Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. In contrast, the United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is "no relationship between [T]himerosal[-]containing vaccines and autism rates in children." This is puzzling because, in a study conducted directly by CDC epidemiologists, a 7.6-fold increased risk of autism from exposure to Thimerosal during infancy was found. The CDC's current stance that Thimerosal is safe and that there is no relationship between Thimerosal and autism is based on six specific published epidemiological studies coauthored and sponsored by the CDC. The purpose of this review is to examine these six publications and analyze possible reasons why their published outcomes are so different from the results of investigations by multiple independent research groups over the past 75+ years.

  12. Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe

    PubMed Central

    Kern, Janet; Geier, David; Haley, Boyd; King, Paul; Geier, Mark

    2014-01-01

    There are over 165 studies that have focused on Thimerosal, an organic-mercury (Hg) based compound, used as a preservative in many childhood vaccines, and found it to be harmful. Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. In contrast, the United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is “no relationship between [T]himerosal[-]containing vaccines and autism rates in children.” This is puzzling because, in a study conducted directly by CDC epidemiologists, a 7.6-fold increased risk of autism from exposure to Thimerosal during infancy was found. The CDC's current stance that Thimerosal is safe and that there is no relationship between Thimerosal and autism is based on six specific published epidemiological studies coauthored and sponsored by the CDC. The purpose of this review is to examine these six publications and analyze possible reasons why their published outcomes are so different from the results of investigations by multiple independent research groups over the past 75+ years. PMID:24995277

  13. A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

    PubMed Central

    Kalwat, Michael A.; Yoder, Stephanie M.; Wang, Zhanxiang; Thurmond, Debbie C.

    2012-01-01

    Human islet studies implicate an important signaling role for the Cdc42 effector protein p21-activated kinase (PAK1) in the sustained/second-phase of insulin secretion. Because human islets from type 2 diabetic donors lack ~80% of normal PAK1 protein levels, the mechanistic requirement for PAK1 signaling in islet function was interrogated. Similar to MIN6 β cells, human islets elicited glucose-stimulated PAK1 activation that was sensitive to the PAK1 inhibitor, IPA3. Given that sustained insulin secretion has been correlated with glucose-induced filamentous actin (F-actin) remodeling, we tested the hypothesis that a Cdc42-activated PAK1 signaling cascade is required to elicit F-actin remodeling to mobilize granules to the cell surface. Live-cell imaging captured the glucose-induced cortical F-actin remodeling in MIN6 β cells; IPA3-mediated inhibition of PAK1 abolished this remodeling. IPA3 also ablated glucose-stimulated insulin granule accumulation at the plasma membrane, consistent with its role in sustained/second-phase insulin release. Both IPA3 and a selective inhibitor of the Cdc42 GTPase, ML-141, blunted the glucose-stimulated activation of Raf-1, suggesting Raf-1 to be downstream of Cdc42→PAK1. IPA3 also inhibited MEK1/2 activation, implicating the MEK1/2→ERK1/2 cascade to occur downstream of PAK1. Importantly, PD0325901, a new selective inhibitor of MEK1/2→ERK1/2 activation, impaired F-actin remodeling and the sustained/amplification pathway of insulin release. Taken together, these data suggest that glucose-mediated activation of Cdc42 leads to activation of PAK1 and prompts activation of its downstream targets Raf-1, MEK1/2 and ERK1/2 to elicit F-actin remodeling and recruitment of insulin granules to the plasma membrane to support the sustained phase of insulin release. PMID:23246867

  14. Mobile Assisted Language Learning and Mnemonic Mapping -- The Loci Method Revisited

    ERIC Educational Resources Information Center

    Waragai, Ikumi; Raindl, Marco; Ohta, Tatsuya; Miyasaka, Kosuke

    2016-01-01

    This paper presents the prototype of a Mobile Language Learning Environment (MLLE) allowing learners of German at a Japanese university to map classroom learning content onto the pathways of their everyday lives, turning places they come by into mnemonic "loci", and thus changing their daily commute into a learning trail. Even though the…

  15. The Effects of a Mobile Gamification App on Elementary Students' Spanish Achievement and Self-Efficacy

    ERIC Educational Resources Information Center

    Rachels, Jason R.; Rockinson-Szapkiw, Amanda J.

    2018-01-01

    A quasi-experimental, pretest-posttest, non-equivalent control group design was used to examine the effect of a mobile gamification application on third and fourth grade students' Spanish language achievement and student academic self-efficacy. In this study, the treatment group's Spanish language instruction was through the use of…

  16. A Seamless Learning Design for Mobile Assisted Language Learning: An Iranian Context

    ERIC Educational Resources Information Center

    Foomani, Elham Mohammadi; Hedayati, Mohsen

    2016-01-01

    Recent developments in information communication technology (ICT) have resulted in a paradigm shift in e-Learning and there is a growing interest in developing design-based research (DBR) focusing on learners and their involvement in knowledge sharing in a contextualized mode. The present study reports a mobile-assisted language learning (MALL)…

  17. How Artefacts Mediate Small-Group Co-Creation Activities in a Mobile-Assisted Seamless Language Learning Environment?

    ERIC Educational Resources Information Center

    Wong, L. -H.; Chen, W.; Jan, M.

    2012-01-01

    The rich learning resources and contexts learners experience in their everyday life could play important roles in complementing formal learning, but are often neglected by learners and teachers. In this paper, we present an intervention study in "Move, Idioms!", a mobile-assisted Chinese language learning approach that emphasizes contextualized…

  18. Learning English through Actions: A Study of Mobile-Assisted Language Learning

    ERIC Educational Resources Information Center

    Liu, Pei-Lin; Chen, Chiu-Jung

    2015-01-01

    This study investigated the impact of taking photos using mobile phones on the English phrase-learning performance of English as a second-language learners. A total of 116 students enrolled in a college in Central Taiwan participated in this study. The participants were divided randomly into two groups: a control group and an experimental group…

  19. Analysis of Students' After-School Mobile-Assisted Artifact Creation Processes in a Seamless Language Learning Environment

    ERIC Educational Resources Information Center

    Wong, Lung-Hsiang

    2013-01-01

    As part of a learner's learning ecology, the informal, out-of-school settings offer virtually boundless opportunities to advance one's learning. This paper reports on "Move, Idioms!", a design for Mobile-Assisted Language Learning experience that accentuates learners' habit of mind and skills in making meaning with their daily…

  20. Research Trends in Mobile Assisted Language Learning from 2000 to 2012

    ERIC Educational Resources Information Center

    Duman, Guler; Orhon, Gunseli; Gedik, Nuray

    2015-01-01

    In order to trace how mobile assisted language learning (MALL) has evolved in recent years, we analysed studies published from 2000 to 2012 to examine their characteristics and research trends. These studies were published in international journals listed in the Social Sciences Citation Index (SSCI). Sixty-nine studies that fit the time frame and…

  1. Understanding Students' Learning Practices: Challenges for Design and Integration of Mobile Technology into Distance Education

    ERIC Educational Resources Information Center

    Viberg, Olga; Grönlund, Åke

    2017-01-01

    This study explores the design requirements for mobile applications for second language learning in online/distance higher education settings. We investigate how students use technology and how they perceive that these technologies-in-practice facilitate their language learning. Structuration Theory is used for the analysis. Results show that…

  2. Mobile-Based Chatting for Meaning Negotiation in Foreign Language Learning

    ERIC Educational Resources Information Center

    Castrillo, María Dolores; Martín-Monje, Elena; Bárcena, Elena

    2014-01-01

    This paper analyzes the adequacy of mobile chatting via Whatsapp for the enhancement of a type of spontaneous and colloquial written interaction which has a strong connection with oral discourse. This is part of a research project undertaken with Spanish students of German as a foreign language with a beginner's or quasi-beginner's level. The…

  3. Special Designed Activities for Learning English Language through the Application of WhatsApp!

    ERIC Educational Resources Information Center

    Zayed, Niveen Mohammad

    2016-01-01

    Students nowadays have strong passion towards the smart mobile phones with all their smart applications. The researcher believes that English language teachers can use the mobile phones, from each now and then, to increase the students' motivation. In this paper, the researcher designed a number of special activities that can be delivered to the…

  4. Instructors' Attitudes towards CALL and MALL in L2 Classrooms

    ERIC Educational Resources Information Center

    Pagel, James W.; Lambacher, Stephen; Reedy, David W.

    2015-01-01

    As part of an ongoing study on learners' and instructors' attitudes toward the use of computers and mobile devices in second-language (L2) learning situations, our purpose here is to identify how language instructors value the use of computers and mobile devices in their teaching. We compare the responses of a survey administered during the past…

  5. Innovative Mobile Robot Method: Improving the Learning of Programming Languages in Engineering Degrees

    ERIC Educational Resources Information Center

    Ortiz, Octavio Ortiz; Pastor Franco, Juan Ángel; Alcover Garau, Pedro María; Herrero Martín, Ruth

    2017-01-01

    This paper describes a study of teaching a programming language in a C programming course by having students assemble and program a low-cost mobile robot. Writing their own programs to define the robot's behavior raised students' motivation. Working in small groups, students programmed the robots by using the control structures of structured…

  6. Pedagogical Values of Mobile-Assisted Task-Based Activities to Enhance Speaking Skill

    ERIC Educational Resources Information Center

    Mohammadi, Mojtaba; Safdari, Nastaran

    2015-01-01

    The purpose of the present study was to examine the impact of online mobile-assisted task-based activities on improving Iranian intermediate English as a Foreign Language (EFL) learners' speaking skills. To achieve the purpose of the study, 90 intermediate language learners were selected ranging between 13 to 16 years old and divided into three…

  7. Short Message Service (SMS) Language and Written Language Skills: Educators' Perspectives

    ERIC Educational Resources Information Center

    Geertsema, Salomé; Hyman, Charene; van Deventer, Chantelle

    2011-01-01

    SMS language is English language slang, used as a means of mobile phone text messaging. This practice may impact on the written language skills of learners at school. The main aim of this study was to determine the perspectives of Grade 8 and 9 English (as Home Language) educators in Gauteng regarding the possible influence of SMS language on…

  8. The Impact of Utilising Mobile Assisted Language Learning (MALL) on Vocabulary Acquisition among Migrant Women English Learners

    ERIC Educational Resources Information Center

    Ahmad, Kham Sila; Armarego, Jocelyn; Sudweeks, Fay

    2017-01-01

    Aim/Purpose: To develop a framework for utilizing Mobile Assisted Language Learning (MALL) to assist non-native English migrant women to acquire English vocabulary in a non-formal learning setting. Background: The women in this study migrated to Australia with varied backgrounds including voluntary or forced migration, very low to high levels of…

  9. Aligning Out-of-Class Material with Curriculum: Tagging Grammar in a Mobile Music Application

    ERIC Educational Resources Information Center

    Sundberg, Ross; Cardoso, Walcir

    2016-01-01

    The time available for classroom language learning is often insufficient for attaining reasonable levels of proficiency in the target language. For this reason, optimising time in the classroom is contingent upon what students are able to do outside of class time. In this paper, we introduce Bande à Part, a mobile application (app) that uses music…

  10. Mobile Assisted Language Learning in University EFL Courses in Japan: Developing Attitudes and Skills for Self-Regulated Learning

    ERIC Educational Resources Information Center

    Kondo, Mutsumi; Ishikawa, Yasushige; Smith, Craig; Sakamoto, Kishio; Shimomura, Hidenori; Wada, Norihisa

    2012-01-01

    This paper reports a project in which researchers at universities in Japan explored the use of Mobile Assisted Language Learning (MALL) practices by developing a learning module intended to help improve students' scores on the TOEIC Listening and Reading Tests. MALL practices are currently being developed at universities in Japan because almost…

  11. A Comparison of Undergraduate Students' English Vocabulary Learning: Using Mobile Phones and Flash Cards

    ERIC Educational Resources Information Center

    Basoglu, Emrah Baki; Akdemir, Omur

    2010-01-01

    Knowing a foreign language has become crucial to reach information. Learning vocabulary is the fundamental step to learn a foreign language. New devices are invented everyday to fulfill the needs of citizens of the twenty-first century. Increased use of mobile phones has made them popular for not only communication, but also entertainment and…

  12. State of the Art of Language Learning Design Using Mobile Technology: Sample Apps and Some Critical Reflection

    ERIC Educational Resources Information Center

    Bárcena, Elena; Read, Timothy; Underwood, Joshua; Obari, Hiroyuki; Cojocnean, Diana; Koyama, Toshiko; Pareja-Lora, Antonio; Calle, Cristina; Pomposo, Lourdes; Talaván, Noa; Ávila-Cabrera, José; Ibañez, Ana; Vermeulen, Anna; Jordano, María; Arús-Hita, Jorge; Rodríguez, Pilar; Castrillo, María Dolores; Kétyi, Andras; Selwood, Jaime; Gaved, Mark; Kukulska-Hulme, Agnes

    2015-01-01

    In this paper, experiences from different research groups illustrate the state-of-the-art of Mobile Assisted Language Learning (henceforth, MALL) in formal and non-formal education. These research samples represent recent and on-going progress made in the field of MALL at an international level and offer encouragement for practitioners who are…

  13. Mobile Assisted Language Learning of Less Commonly Taught Languages: Learning in an Incidental and Situated Way through an App

    ERIC Educational Resources Information Center

    Cervini, Cristiana; Solovova, Olga; Jakkula, Annukka; Ruta, Karolina

    2016-01-01

    Learning has been moving out of classrooms into virtual and physical spaces for over a decade now (Naismith, Lonsdale, Vavoula, & Sharples, 2004). It is becoming mobile "in space", i.e. carried across various domains (workplace, home, places of leisure), "in time", as it encompasses different moments of the day, and in…

  14. Development of Listening and Linguistic Skills through the Use of a Mobile Application

    ERIC Educational Resources Information Center

    Ramos, Lizeth; Valderruten, Arturo

    2017-01-01

    The purpose of this article is to present the results of a research that was developed with eight groups of students of undergraduate programs of the Language Institute at Santiago de Cali University. The research was developed with four groups of students who used a mobile application developed jointly by foreign language professors, a software…

  15. Minority Languages and Performative Genres: The Case of Irish Language Stand-Up Comedy

    ERIC Educational Resources Information Center

    Moriarty, Mairead

    2011-01-01

    This article will examine the potential for language change from the bottom-up given the new domains in which minority languages are present as a result of the process of language mobility. Drawing on a theoretical notion of sociolinguistic scales, this article aims to discuss how the position of the Irish language has been reconfigured. From this…

  16. The step-wise pathway of septin hetero-octamer assembly in budding yeast.

    PubMed

    Weems, Andrew; McMurray, Michael

    2017-05-25

    Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers. Cells choose from a variety of available septins to assemble distinct hetero-oligomers, but the underlying mechanism was unknown. Using a new in vivo assay, we find that a stepwise assembly pathway produces the two species of budding yeast septin hetero-octamers: Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-Cdc11/Shs1. Rapid GTP hydrolysis by monomeric Cdc10 drives assembly of the core Cdc10 homodimer. The extended Cdc3 N terminus autoinhibits Cdc3 association with Cdc10 homodimers until prior Cdc3-Cdc12 interaction. Slow hydrolysis by monomeric Cdc12 and specific affinity of Cdc11 for transient Cdc12•GTP drive assembly of distinct trimers, Cdc11-Cdc12-Cdc3 or Shs1-Cdc12-Cdc3. Decreasing the cytosolic GTP:GDP ratio increases the incorporation of Shs1 vs Cdc11, which alters the curvature of filamentous septin rings. Our findings explain how GTP hydrolysis controls septin assembly, and uncover mechanisms by which cells construct defined septin complexes.

  17. Pattern of growth of very low birth weight preterm infants, assessed using the WHO Growth Standards, is associated with neurodevelopment.

    PubMed

    Nash, Andrea; Dunn, Michael; Asztalos, Elizabeth; Corey, Mary; Mulvihill-Jory, Bridget; O'Connor, Deborah L

    2011-08-01

    Several Canadian professional organizations recently recommended that the growth of preterm infants be monitored using the World Health Organization Growth Standards (WHO-GS) after hospital discharge. The WHO-GS are a prescriptive set of growth charts that describe how term infants should grow under ideal environmental conditions. Whether preterm infants following this pattern of growth have better outcomes than infants that do not has yet to be evaluated. Our aim was to determine whether the pattern of growth of very low birth weight (VLBW) infants during the first 2 years, assessed using the WHO-GS or the traditional Centers for Disease Control and Prevention reference growth charts (CDC-RGC), is associated with neurodevelopment. Pattern of weight, length, and head circumference gain of appropriate-for-gestation VLBW preterm infants (n = 289) from birth to 18-24 months corrected age was classified, using the WHO-GS and CDC-RGC, as sustained (change in Z-score ≤1 SD), decelerated (decline >1 SD), or accelerated (incline >1 SD). Development was assessed using the Bayley Scales of Infant and Toddler Development (BSID)-III at 18-24 months corrected age. Using the WHO-GS, children with a decelerated pattern of weight gain had lower cognitive (10 points), language (6 points), and motor (4 points) scores than infants with sustained weight gain (p < 0.05), even after adjustment for morbidities. No association was found using the CDC-RGC. In conclusion, a decelerated pattern of weight gain, determined with the WHO-GS, but not the CDC-GRC, is associated with poorer neurodevelopment scores on the BSID-III than a pattern of sustained growth.

  18. Design of a Template for Handwriting Based Hindi Text Entry in Handheld Devices

    NASA Astrophysics Data System (ADS)

    Gangopadhyay, Diya; Vasal, Ityam; Yammiyavar, Pradeep

    Mobile phones, in the recent times, have become affordable and accessible to a wider range of users including the hitherto technologically and economically under-represented segments. Indian users are a gigantic consumer base for mobile phones. With Hindi being one of the most widely spoken languages in the country and the primary tool of communication for about a third of its population, an effective solution for Hindi text entry in mobile devices is expected to be immensely useful to the non English speaking users. This paper proposes a mobile phone handwriting based text entry solution for Hindi language, which allows for an easy text entry method, while facilitating better recognition accuracy.

  19. NOW: A Workflow Language for Orchestration in Nomadic Networks

    NASA Astrophysics Data System (ADS)

    Philips, Eline; van der Straeten, Ragnhild; Jonckers, Viviane

    Existing workflow languages for nomadic or mobile ad hoc networks do not offer adequate support for dealing with the volatile connections inherent to these environments. Services residing on mobile devices are exposed to (temporary) network failures, which should be considered the rule rather than the exception. This paper proposes a nomadic workflow language built on top of an ambient-oriented programming language which supports dynamic service discovery and communication primitives resilient to network failures. Our proposed language provides high level workflow abstractions for control flow and supports rich network and service failure detection and handling through compensating actions. Moreover, we introduce a powerful variable binding mechanism which enables dynamic data flow between services in a nomadic environment. By adding this extra layer of abstraction on top of an ambient-oriented programming language, the application programmer is offered a flexible way to develop applications for nomadic networks.

  20. Applang - A DSL for specification of mobile applications for android platform based on textX

    NASA Astrophysics Data System (ADS)

    Kosanović, Milan; Dejanović, Igor; Milosavljević, Gordana

    2016-06-01

    Mobile platforms become a ubiquitous part of our daily lives thus making more pressure to software developers to develop more applications faster and with the support for different mobile operating systems. To foster the faster development of mobile services and applications and to support various mobile operating systems a new software development approaches must be undertaken. Domain-Specific Languages (DSL) are a viable approach that promise to solve a problem of target platform diversity as well as to facilitate rapid application development and shorter time-to-market. This paper presents Applang, a DSL for the specification of mobile applications for the Android platform, based on textX meta-language. The application is described using Applang DSL and the source code for a target platform is automatically generated by the provided code generator. The same application defined using single Applang source can be transformed to various targets with little or no manual modifications.

  1. We Need to Communicate! Helping Hearing Parents of Deaf Children Learn American Sign Language

    ERIC Educational Resources Information Center

    Weaver, Kimberly A.; Starner, Thad

    2011-01-01

    Language immersion from birth is crucial to a child's language development. However, language immersion can be particularly challenging for hearing parents of deaf children to provide as they may have to overcome many difficulties while learning American Sign Language (ASL). We are in the process of creating a mobile application to help hearing…

  2. Implementing Mobile-Assisted Language Learning (MALL) in an EFL Context: Iranian EFL Teachers' Perspectives on Challenges and Affordances

    ERIC Educational Resources Information Center

    Dashtestani, Reza

    2013-01-01

    The implementation of computer-assisted language learning (CALL) has provided tremendous opportunities for language teachers to promote their computer literacy and adopt a learner-centered approach to teaching. Accordingly, with the rising advent of language learning technologies, language teachers would occupy a fundamental role in preparing and…

  3. Measurement Invariance of the Short Version of the Problematic Mobile Phone Use Questionnaire (PMPUQ-SV) across Eight Languages.

    PubMed

    Lopez-Fernandez, Olatz; Kuss, Daria J; Pontes, Halley M; Griffiths, Mark D; Dawes, Christopher; Justice, Lucy V; Männikkö, Niko; Kääriäinen, Maria; Rumpf, Hans-Jürgen; Bischof, Anja; Gässler, Ann-Kathrin; Romo, Lucia; Kern, Laurence; Morvan, Yannick; Rousseau, Amélie; Graziani, Pierluigi; Demetrovics, Zsolt; Király, Orsolya; Schimmenti, Adriano; Passanisi, Alessia; Lelonek-Kuleta, Bernadeta; Chwaszcz, Joanna; Chóliz, Mariano; Zacarés, Juan José; Serra, Emilia; Dufour, Magali; Rochat, Lucien; Zullino, Daniele; Achab, Sophia; Landrø, Nils Inge; Suryani, Eva; Hormes, Julia M; Terashima, Javier Ponce; Billieux, Joël

    2018-06-08

    The prevalence of mobile phone use across the world has increased greatly over the past two decades. Problematic Mobile Phone Use (PMPU) has been studied in relation to public health and comprises various behaviours, including dangerous, prohibited, and dependent use. These types of problematic mobile phone behaviours are typically assessed with the short version of the Problematic Mobile Phone Use Questionnaire (PMPUQ⁻SV). However, to date, no study has ever examined the degree to which the PMPU scale assesses the same construct across different languages. The aims of the present study were to (i) determine an optimal factor structure for the PMPUQ⁻SV among university populations using eight versions of the scale (i.e., French, German, Hungarian, English, Finnish, Italian, Polish, and Spanish); and (ii) simultaneously examine the measurement invariance (MI) of the PMPUQ⁻SV across all languages. The whole study sample comprised 3038 participants. Descriptive statistics, correlations, and Cronbach's alpha coefficients were extracted from the demographic and PMPUQ-SV items. Individual and multigroup confirmatory factor analyses alongside MI analyses were conducted. Results showed a similar pattern of PMPU across the translated scales. A three-factor model of the PMPUQ-SV fitted the data well and presented with good psychometric properties. Six languages were validated independently, and five were compared via measurement invariance for future cross-cultural comparisons. The present paper contributes to the assessment of problematic mobile phone use because it is the first study to provide a cross-cultural psychometric analysis of the PMPUQ-SV.

  4. Logistics Support Analysis Techniques Guide

    DTIC Science & Technology

    1985-03-15

    LANGUAGE (DATA RECORDS) FORTRAN CDC 6600 D&V FSD P/D A H REMA-RKS: Program n-s-ists of F PLIATIffIONS, approx 4000 line of coding , 3 Safegard, AN/FSC... FORTRAN IV -EW-RAK9-- The model consz.sts of IT--k-LIC- I-U-0NS: approximately 367 lines of SiNCGARS, PERSHING II coding . %.’. ~ LSA TASK INTERFACE...system supported by Computer’ Systems Command. The current version of LADEN is coded totally in FORTRAN 󈧕 for virtual memory operating system

  5. Optimization of thermal protection systems for the space vehicle. Volume 2: User's manual

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The development of the computational techniques for the design optimization of thermal protection systems for the space shuttle vehicle are discussed. The resulting computer program was then used to perform initial optimization and sensitivity studies on a typical thermal protection system (TPS) to demonstrate its application to the space shuttle TPS design. The program was developed in FORTRAN IV for CDC 6400 computer, but it was subsequently converted to the FORTRAN V language to be used on the Univac 1108.

  6. Engaging Language Learners through Technology Integration: Theory, Applications, and Outcomes

    ERIC Educational Resources Information Center

    Li, Shuai, Ed.; Swanson, Peter, Ed.

    2014-01-01

    Web 2.0 technologies, open source software platforms, and mobile applications have transformed teaching and learning of second and foreign languages. Language teaching has transitioned from a teacher-centered approach to a student-centered approach through the use of Computer-Assisted Language Learning (CALL) and new teaching approaches.…

  7. Students and Teachers' Perceptions into the Viability of Mobile Technology Implementation to Support Language Learning for First Year Business Students in a Middle Eastern University

    ERIC Educational Resources Information Center

    Tayan, Bilal M.

    2017-01-01

    Advancements in technology have enabled us to learn, adapt and exploit our skills and knowledge in new ways. Appreciating the potential of technology may yet give growth and enrich the process of language education, particularly through a student-centred mobile learning environment. Consequently, a constructivist approach to learning can create…

  8. A Look at Advanced Learners' Use of Mobile Devices for English Language Study: Insights from Interview Data

    ERIC Educational Resources Information Center

    Kruk, Mariusz

    2017-01-01

    The paper discusses the results of a study which explored advanced learners of English engagement with their mobile devices to develop learning experiences that meet their needs and goals as foreign language learners. The data were collected from 20 students by means of a semi-structured interview. The gathered data were subjected to qualitative…

  9. Integrating Socio-Cultural Contexts and Location-based Systems for Ubiquitous Language Learning in Museums: A State of the Art Review of 2009-2014

    ERIC Educational Resources Information Center

    Wang, Hong-You; Liu, Gi-Zen; Hwang, Gwo-Jen

    2017-01-01

    Context-dependent learning systems are now becoming more common in museums, as most students are equipped with mobile devices. As there has been little research into context-aware mobile applications in museums, the present study aims to investigate ubiquitous language learning in socio-cultural contexts, as well as recent trends in using…

  10. Using Mobile-Based Email for English Foreign Language Learners

    ERIC Educational Resources Information Center

    Alzu'bi, Mohammad Akram mohammad; Sabha, Muhannad Rushdi Nimer

    2013-01-01

    This study aimed at investigating the role of Mobile-based Email in improving Ajloun College English Students' Achievement. It attempts to answer the following questions: What is the potential contribution of mobile-based email exchanged to writing skills? What is the potential contribution of mobile-based email exchanged to vocabulary…

  11. Translation, Cross-Cultural Adaptation, and Validation of the Malay Version of the System Usability Scale Questionnaire for the Assessment of Mobile Apps.

    PubMed

    Mohamad Marzuki, Muhamad Fadhil; Yaacob, Nor Azwany; Yaacob, Najib Majdi

    2018-05-14

    A mobile app is a programmed system designed to be used by a target user on a mobile device. The usability of such a system refers not only to the extent to which product can be used to achieve the task that it was designed for, but also its effectiveness and efficiency, as well as user satisfaction. The System Usability Scale is one of the most commonly used questionnaires used to assess the usability of a system. The original 10-item version of System Usability Scale was developed in English and thus needs to be adapted into local languages to assess the usability of a mobile apps developed in other languages. The aim of this study is to translate and validate (with cross-cultural adaptation) the English System Usability Scale questionnaire into Malay, the main language spoken in Malaysia. The development of a translated version will allow the usability of mobile apps to be assessed in Malay. Forward and backward translation of the questionnaire was conducted by groups of Malay native speakers who spoke English as their second language. The final version was obtained after reconciliation and cross-cultural adaptation. The content of the Malay System Usability Scale questionnaire for mobile apps was validated by 10 experts in mobile app development. The efficacy of the questionnaire was further probed by testing the face validity on 10 mobile phone users, followed by reliability testing involving 54 mobile phone users. The content validity index was determined to be 0.91, indicating good relevancy of the 10 items used to assess the usability of a mobile app. Calculation of the face validity index resulted in a value of 0.94, therefore indicating that the questionnaire was easily understood by the users. Reliability testing showed a Cronbach alpha value of .85 (95% CI 0.79-0.91) indicating that the translated System Usability Scale questionnaire is a reliable tool for the assessment of usability of a mobile app. The Malay System Usability Scale questionnaire is a valid and reliable tool to assess the usability of mobile app in Malaysia. ©Muhamad Fadhil Mohamad Marzuki, Nor Azwany Yaacob, Najib Majdi Yaacob. Originally published in JMIR Human Factors (http://humanfactors.jmir.org), 14.05.2018.

  12. In the Name of Language: School-Based Language Revitalization, Strategic Solidarities, and State Power in the French Basque Country

    ERIC Educational Resources Information Center

    Heidemann, Kai A.

    2014-01-01

    This article explores the mobilization dynamics of a school-based minority language revitalization initiative in the French Basque Country, known as the Ikastola Movement. Bringing the study of language revitalization into dialogue with social movement theory, I discuss how the solidarity of Basque language activists was influenced by state-level…

  13. "Seamlessly" Learning Chinese: Contextual Meaning Making and Vocabulary Growth in a Seamless Chinese as a Second Language Learning Environment

    ERIC Educational Resources Information Center

    Wong, Lung-Hsiang; King, Ronnel B.; Chai, Ching Sing; Liu, May

    2016-01-01

    Second language learners are typically hampered by the lack of a natural environment to use the target language for authentic communication purpose (as a means for "learning by applying"). Thus, we propose MyCLOUD, a mobile-assisted seamless language learning approach that aims to nurture a second language social network that bridges…

  14. Feasibility study for a numerical aerodynamic simulation facility. Volume 3: FMP language specification/user manual

    NASA Technical Reports Server (NTRS)

    Kenner, B. G.; Lincoln, N. R.

    1979-01-01

    The manual is intended to show the revisions and additions to the current STAR FORTRAN. The changes are made to incorporate an FMP (Flow Model Processor) for use in the Numerical Aerodynamic Simulation Facility (NASF) for the purpose of simulating fluid flow over three-dimensional bodies in wind tunnel environments and in free space. The FORTRAN programming language for the STAR-100 computer contains both CDC and unique STAR extensions to the standard FORTRAN. Several of the STAR FORTRAN extensions to standard FOR-TRAN allow the FORTRAN user to exploit the vector processing capabilities of the STAR computer. In STAR FORTRAN, vectors can be expressed with an explicit notation, functions are provided that return vector results, and special call statements enable access to any machine instruction.

  15. Using Ontologies to Interlink Linguistic Annotations and Improve Their Accuracy

    ERIC Educational Resources Information Center

    Pareja-Lora, Antonio

    2016-01-01

    For the new approaches to language e-learning (e.g. language blended learning, language autonomous learning or mobile-assisted language learning) to succeed, some automatic functions for error correction (for instance, in exercises) will have to be included in the long run in the corresponding environments and/or applications. A possible way to…

  16. Tuning University Undergraduates for High Mobility and Employability under the Content and Language Integrated Learning Approach

    ERIC Educational Resources Information Center

    Yang, Wenhsien

    2017-01-01

    Globalisation affects both language use and the economics of higher education. Considering how to design new instructional approaches to prepare graduates with competence in using language and professional knowledge interactively and interculturally has thus become a major concern of higher education institutes. Content and language integrated…

  17. Urban Explorations for Language Learning: A Gamified Approach to Teaching Italian in a University Context

    ERIC Educational Resources Information Center

    Charitonos, Koula; Morini, Luca; Arnab, Sylvester; Cervi-Wilson, Tiziana; Brick, Billy

    2016-01-01

    The recent technological developments and widespread use of mobile technologies challenge traditional knowledge and skills, with language learning increasingly taking place beyond the language classroom in learners' own environments. The paper presents the ImparApp study that focuses on a pervasive and gamified approach to language teaching and…

  18. CALL and Less Commonly Taught Languages--Still a Way to Go

    ERIC Educational Resources Information Center

    Ward, Monica

    2016-01-01

    Many Computer Assisted Language Learning (CALL) innovations mainly apply to the Most Commonly Taught Languages (MCTLs), especially English. Recent manifestations of CALL for MCTLs such as corpora, Mobile Assisted Language Learning (MALL) and Massively Open Online Courses (MOOCs) are found less frequently in the world of Less Commonly Taught…

  19. Integrating Mobile Phones into the EFL Foundation Year Classroom in King Abdulaziz University/KSA: Effects on Achievement in General English and Students' Attitudes

    ERIC Educational Resources Information Center

    Khrisat, Abdulhafeth A.; Mahmoud, Salameh Saleem

    2013-01-01

    This study investigates the effect of ten teaching English as a foreign language (TEFL) oriented features of mobile phones in the English language classroom on the achievement of foundation-year students in King Abdulaziz University (KAU) in General English. The study also explores students' attitudes towards this new method of teaching. The study…

  20. Investigating Learner Preparedness for and Usage Patterns of Mobile Learning

    ERIC Educational Resources Information Center

    Stockwell, Glenn

    2008-01-01

    While the use of mobile devices for language learning has sparked the interest of an increasing number of researchers in recent years (e.g., Aizawa & Kiernan, 2003; Thornton & Houser, 2005), our knowledge of learners' preferences for the mobile platform and their usage patterns remains limited. Are learners prepared to use mobile phones…

  1. Parochialism and Intercourse: Metaphors for Mobility.

    ERIC Educational Resources Information Center

    Edwards, John

    1994-01-01

    Discusses tensions resulting from dichotomies existing between "smaller" languages and those of wider communications. It is suggested that there are four recurring approaches for dealing with this tension: communicative language shift, defense of the more threatened variety, "localization" of the stronger language (for example,…

  2. Development and evaluation of a mobile AAC: a virtual therapist and speech assistant for people with communication disabilities.

    PubMed

    Wang, Erh-Hsuan; Zhou, Leming; Chen, Szu-Han Kay; Hill, Katya; Parmanto, Bambang

    2017-09-26

    The currently existing Augmentative and Alternative Communication (AAC) technologies have limitations to produce the best communication rehabilitation outcomes and therefore a better solution is needed. In this work, a mobile AAC app was developed based on results from research studies. Sophisticated AAC language programming, embedded training materials, and real-time communication performance reporting were integrated into the app. Two groups of study participants were recruited to participate a usability study and a preliminary feasibility study for the purpose of evaluating this mobile AAC app, respectively. A tablet-based AAC app was developed to support communication rehabilitation. User studies of the app were conducted and included able-bodied individuals and people with verbal communication disabilities. All study participants agreed that the app establishes a usable alternative treatment protocol for communication rehabilitation. The app's integrated features have great potential to maximize users' communication effectiveness, enhance language skills, and ultimately improve users' quality of life. Implications for rehabilitation We have developed and evaluated an integrated mobile AAC language-based app. This tablet-based app integrated AAC with embedded trainings and real-time performance report.

  3. Language and Opportunity in the "Land of Opportunity": Latina Immigrants' Reflections on Language Learning and Professional Mobility

    ERIC Educational Resources Information Center

    Davila, Liv Thorstensson

    2008-01-01

    This study analyzes the goals and realities of four educated, working, adult Latina, English as a Second language (ESL) students living in North Carolina, a region seeing particularly intense migration of Latino immigrants. The study conceptually frames adjustment issues confronted by these Latina immigrants in terms of gender, language,…

  4. Multilingualism in the Workplace: Language Practices in Multilingual Contexts

    ERIC Educational Resources Information Center

    Angouri, Jo

    2014-01-01

    The modern workplace is international and multilingual. Both white and blue collar employees are expected to be mobile, work increasingly in (virtual) teams (Gee et al. 1996) and to address complex organisational issues in a language that, often, is not their first language (L1). This results in a number of languages forming the ecosystem of…

  5. Informal Language Learning in Authentic Setting, Using Mobile Devices and SNS

    ERIC Educational Resources Information Center

    Aladjem, Ruthi; Jou, Bibiana

    2016-01-01

    One of the challenges of teaching a foreign language in non-immersive contexts, is extending the exposure of learners to the target language, beyond school hours. Since it is quite common to find linguistic and cultural exponents of foreign languages, in authentic contexts (i.e., the "Linguistic Landscape"), those exponents may serve as…

  6. Moving Globally to Transform Locally? Academic Mobility and Language Policy in Brazil

    ERIC Educational Resources Information Center

    Archanjo, Renata

    2017-01-01

    This paper discusses academic mobility in Brazil over the past few years due to the increase in governmental initiatives to promote internationalization of higher education and student mobility. The aim is to address the challenges faced by the international academic mobility program Science without Borders (SwB) to boost the development of…

  7. Path querying system on mobile devices

    NASA Astrophysics Data System (ADS)

    Lin, Xing; Wang, Yifei; Tian, Yuan; Wu, Lun

    2006-01-01

    Traditional approaches to path querying problems are not efficient and convenient under most circumstances. A more convenient and reliable approach to this problem has to be found. This paper is devoted to a path querying solution on mobile devices. By using an improved Dijkstra's shortest path algorithm and a natural language translating module, this system can help people find the shortest path between two places through their cell phones or other mobile devices. The chosen path is prompted in text of natural language, as well as a map picture. This system would be useful in solving best path querying problems and have potential to be a profitable business system.

  8. MALL Technology: Use of Academic Podcasting in the Foreign Language Classroom

    ERIC Educational Resources Information Center

    Abdous, M'hammed; Camarena, Margaret M.; Facer, Betty Rose

    2009-01-01

    Integrating Mobile Assisted Language Learning (MALL) technology (personal multimedia players, cell phones, and handheld devices) into the foreign language curriculum is becoming commonplace in many secondary and higher education institutions. Current research has identified both pedagogically sound applications and important benefits to students.…

  9. Portuguese "to Go": Language Representations in Tourist Guides

    ERIC Educational Resources Information Center

    Cordeiro, Maria Joao

    2011-01-01

    Language difference is an intrinsic aspect of any kind of mobility and especially of tourism, the world's allegedly largest industry which develops around a myriad of multilingual and multicultural places. However, multilingualism and the intense intermingling of languages characterizing tourist sites are considered a potentially chaos-creating…

  10. From Multilingualism to Bilingualism: Changes in Language Use, Language Value, and Social Mobility among Engdewu Speakers in the Solomon Islands

    ERIC Educational Resources Information Center

    Emerine Hicks, Rachel

    2017-01-01

    On the island of Santa Cruz in the Solomon Islands, the Engdewu language is facing imminent language shift because of the increasing use of the lingua franca Solomon Islands Pijin in the community. In this article, I argue that this language shift is occurring because of changes to the social structure in Baemawz, one of the villages where Engdewu…

  11. Global Access through Languages. Dimension '96. Selected Proceedings of the Joint Conference of the Southern Conference on Language Teaching and the Alabama Association of Foreign Language Teachers (Mobile, Alabama, 1996).

    ERIC Educational Resources Information Center

    Terry, Robert M., Ed.

    Six conference papers are presented in this volume. They include: "Living Civilization: a Theoretical Model for Using Task-Based Activities To Combine the Teaching of Language and Culture" (Sharon Gwinn Scinicariello); "Foreign Language Reading versus Understanding: Using Think-Aloud Protocols To Identify L2 Reading Problems"…

  12. CDC25A phosphatase controls meiosis I progression in mouse oocytes.

    PubMed

    Solc, Petr; Saskova, Adela; Baran, Vladimir; Kubelka, Michal; Schultz, Richard M; Motlik, Jan

    2008-05-01

    CDK1 is a pivotal regulator of resumption of meiosis and meiotic maturation of oocytes. CDC25A/B/C are dual-specificity phosphatases and activate cyclin-dependent kinases (CDKs). Although CDC25C is not essential for either mitotic or meiotic cell cycle regulation, CDC25B is essential for CDK1 activation during resumption of meiosis. Cdc25a -/- mice are embryonic lethal and therefore a role for CDC25A in meiosis is unknown. We report that activation of CDK1 results in a maturation-associated decrease in the amount of CDC25A protein, but not Cdc25a mRNA, such that little CDC25A is present by metaphase I. In addition, expression of exogenous CDC25A overcomes cAMP-mediated maintenance of meiotic arrest. Microinjection of Gfp-Cdc25a and Gpf-Cdc25b mRNAs constructs reveals that CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. Over-expressing GFP-CDC25A, which compensates for the normal maturation-associated decrease in CDC25A, blocks meiotic maturation at MI. This MI block is characterized by defects in chromosome congression and spindle formation and a transient reduction in both CDK1 and MAPK activities. Lastly, RNAi-mediated reduction of CDC25A results in fewer oocytes resuming meiosis and reaching MII. These data demonstrate that CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI-MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes.

  13. Internationalization of Higher Education and Language Policy: The Case of a Bilingual University in Taiwan

    ERIC Educational Resources Information Center

    Lau, Ken; Lin, Chia-Yen

    2017-01-01

    Universities worldwide, in placing a greater emphasis on global mobility, have recently seen a growing number of in- and outbound students. Parallel to this development has been the need to internationalize individual campuses, an important aspect of which is to have a common language (or languages) used for communication. The language policies in…

  14. Facilitating Exposure to Sign Languages of the World: The Case for Mobile Assisted Language Learning

    ERIC Educational Resources Information Center

    Parton, Becky Sue

    2014-01-01

    Foreign sign language instruction is an important, but overlooked area of study. Thus the purpose of this paper was two-fold. First, the researcher sought to determine the level of knowledge and interest in foreign sign language among Deaf teenagers along with their learning preferences. Results from a survey indicated that over a third of the…

  15. Perceived Convenience in an Extended Technology Acceptance Model: Mobile Technology and English Learning for College Students

    ERIC Educational Resources Information Center

    Chang, Chi-Cheng; Yan, Chi-Fang; Tseng, Ju-Shih

    2012-01-01

    Since convenience is one of the features for mobile learning, does it affect attitude and intention of using mobile technology? The technology acceptance model (TAM), proposed by David (1989), was extended with perceived convenience in the present study. With regard to English language mobile learning, the variables in the extended TAM and its…

  16. The Motivational Dimension of Language Teaching

    ERIC Educational Resources Information Center

    Lamb, Martin

    2017-01-01

    Motivation is recognized as a vital component in successful second language learning, and has been the subject of intensive research in recent decades. This review focuses on a growing branch of this research effort, that which examines the motivational effects of language teaching. This is pertinent because, despite enhanced mobility and…

  17. Integration, Language, and Practice: Wittgenstein and Interdisciplinary Communication

    ERIC Educational Resources Information Center

    Piso, Zachary

    2015-01-01

    The dominant account of interdisciplinary integration mobilizes linguistic metaphors such as bilingualism or the learning of new languages. While there is something right about these linguistic metaphors, I urge caution about philosophical confusions that can arise in the absence of careful scrutiny of how our language relates to the world.…

  18. The Role of Language in the Dissolution of the Soviet Union.

    ERIC Educational Resources Information Center

    Marshall, David F.

    A study examines the dynamics of cultural pluralism and language in the ethnic mobilization, and resulting dissolution, of the USSR. It first examines ethnic composition, dominant nationalities, language groups without separate nationalities, patterns of ethnic populations within nationalities, and the influence of this multiculturalism on…

  19. The GPRIME approach to finite element modeling

    NASA Technical Reports Server (NTRS)

    Wallace, D. R.; Mckee, J. H.; Hurwitz, M. M.

    1983-01-01

    GPRIME, an interactive modeling system, runs on the CDC 6000 computers and the DEC VAX 11/780 minicomputer. This system includes three components: (1) GPRIME, a user friendly geometric language and a processor to translate that language into geometric entities, (2) GGEN, an interactive data generator for 2-D models; and (3) SOLIDGEN, a 3-D solid modeling program. Each component has a computer user interface of an extensive command set. All of these programs make use of a comprehensive B-spline mathematics subroutine library, which can be used for a wide variety of interpolation problems and other geometric calculations. Many other user aids, such as automatic saving of the geometric and finite element data bases and hidden line removal, are available. This interactive finite element modeling capability can produce a complete finite element model, producing an output file of grid and element data.

  20. Transformations: Mobile Interaction & Language Learning

    ERIC Educational Resources Information Center

    Carroll, Fiona; Kop, Rita; Thomas, Nathan; Dunning, Rebecca

    2015-01-01

    Mobile devices and the interactions that these technologies afford have the potential to change the face and nature of education in our schools. Indeed, mobile technological advances are seen to offer better access to educational material and new interactive ways to learn. However, the question arises, as to whether these new technologies are…

  1. Mobile Assisted Language Learning Experiences

    ERIC Educational Resources Information Center

    Kim, Daesang; Ruecker, Daniel; Kim, Dong-Joong

    2017-01-01

    The purpose of this study was to investigate the benefits of learning with mobile technology for TESOL students and to explore their perceptions of learning with this type of technology. The study provided valuable insights on how students perceive and adapt to learning with mobile technology for effective learning experiences for both students…

  2. Learning with Mobiles in Developing Countries: Technology, Language, and Literacy

    ERIC Educational Resources Information Center

    Traxler, John M.

    2017-01-01

    In the countries of the global South, the challenges of fixed infrastructure and environment, the apparent universality of mobile hardware, software and network technologies and the rhetoric of the global knowledge economy have slowed or impoverished the development of appropriate theoretical discourses to underpin learning with mobiles. This…

  3. MALL: The Pedagogical Challenges

    ERIC Educational Resources Information Center

    Burston, Jack

    2014-01-01

    In this paper the development of mobile-assisted language learning (MALL) over the past 20 years is reviewed with a particular focus on the pedagogical challenges facing its exploitation. Following a consideration of the definition of mobile learning, the paper describes the dominant mobile technologies upon which MALL applications have been…

  4. Reading and Grammar Learning through Mobile Phones

    ERIC Educational Resources Information Center

    Wang, Shudong; Smith, Simon

    2013-01-01

    This paper describes an ongoing language-learning project, three years into its development. We examine both the feasibility and the limitations of developing English reading and grammar skills through the interface of mobile phones. Throughout the project, reading and grammar materials were regularly sent to students' mobile phones. Students read…

  5. Effectiveness of Vocabulary Learning via Mobile Phone

    ERIC Educational Resources Information Center

    Lu, M.

    2008-01-01

    Whereas the penetration of mobile phones in Asian countries keeps climbing, little research has explored the application of the short message service (SMS) in second language learning. This study aims to examine the effectiveness of SMS vocabulary lessons of limited lexical information on the small screens of mobile phones. Thirty high school…

  6. Symbolic dynamic filtering and language measure for behavior identification of mobile robots.

    PubMed

    Mallapragada, Goutham; Ray, Asok; Jin, Xin

    2012-06-01

    This paper presents a procedure for behavior identification of mobile robots, which requires limited or no domain knowledge of the underlying process. While the features of robot behavior are extracted by symbolic dynamic filtering of the observed time series, the behavior patterns are classified based on language measure theory. The behavior identification procedure has been experimentally validated on a networked robotic test bed by comparison with commonly used tools, namely, principal component analysis for feature extraction and Bayesian risk analysis for pattern classification.

  7. From Computer Assisted Language Learning (CALL) to Mobile Assisted Language Use (MALU)

    ERIC Educational Resources Information Center

    Jarvis, Huw; Achilleos, Marianna

    2013-01-01

    This article begins by critiquing the long-established acronym CALL (Computer Assisted Language Learning). We then go on to report on a small-scale study which examines how student non-native speakers of English use a range of digital devices beyond the classroom in both their first (L1) and second (L2) languages. We look also at the extent to…

  8. Optimising the Use of Wireless Application Protocol (WAP) Sites for Listening Activities in a Korean English as a Foreign Language (EFL) Context

    ERIC Educational Resources Information Center

    Nah, Ki Chune

    2011-01-01

    Using the Internet through a mobile phone for learning English as a foreign language (EFL) listening skills has significant potential, and language learners in South Korea hold clearly positive attitudes towards using this. However, the barriers discouraging language learners from using the Internet for EFL listening have not yet been thoroughly…

  9. Mobile Purposive-Extensive-Podcast-Listening versus Mobile Self-Regulated-Podcast-Development: A Critical Framework for Designing Foreign Language Listening

    ERIC Educational Resources Information Center

    Sendag, Serkan; Caner, Mustafa; Kafes, Hüseyin

    2014-01-01

    Nowadays mobile technologies are widely employed in almost all fields of education for varying reasons. The present study intends to explore the role of mobile technologies in the development of students' listening skills in a higher education context. The aim of the present study is twofold; while it seeks for the feasibility of mobile…

  10. LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

    PubMed Central

    Brachet, Anna; Norwood, Stephanie; Brouwers, Jos F.; Palomer, Ernest; Helms, J. Bernd

    2015-01-01

    Neurotransmitter receptor trafficking during synaptic plasticity requires the concerted action of multiple signaling pathways and the protein transport machinery. However, little is known about the contribution of lipid metabolism during these processes. In this paper, we addressed the question of the role of cholesterol in synaptic changes during long-term potentiation (LTP). We found that N-methyl-d-aspartate–type glutamate receptor (NMDAR) activation during LTP induction leads to a rapid and sustained loss or redistribution of intracellular cholesterol in the neuron. A reduction in cholesterol, in turn, leads to the activation of Cdc42 and the mobilization of GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid–type glutamate receptors (AMPARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation. This process is accompanied by an increase of NMDAR function and an enhancement of LTP. These results imply that cholesterol acts as a sensor of NMDAR activation and as a trigger of downstream signaling to engage small GTPase (guanosine triphosphatase) activation and AMPAR synaptic delivery during LTP. PMID:25753037

  11. The effect of DNA replication on mutation of the Saccharomyces cerevisiae CDC8 gene.

    PubMed

    Zaborowska, D; Zuk, J

    1990-04-01

    Incubation in YPD medium under permissive conditions when DNA replication is going on, strongly stimulates the induction of cdc+ colonies of UV-irradiated cells of yeast strains HB23 (cdc8-1/cdc8-3), HB26 (cdc8-3/cdc8-3) and HB7 (cdc8-1/cdc8-1). Inhibition of DNA replication by hydroxyurea, araCMP, cycloheximide or caffeine or else by incubation in phosphate buffer pH 7.0, abolishes this stimulation. Thus the replication of DNA is strongly correlated with the high induction of cdc+ colonies by UV irradiation. It is postulated that these UV-induced cdc+ colonies arise as the result infidelity in DNA replication.

  12. Language Policy and Orthographic Harmonization across Linguistic, Ethnic and National Boundaries in Southern Africa

    ERIC Educational Resources Information Center

    Banda, Felix

    2016-01-01

    Drawing on online and daily newspapers, speakers' language and writing practices, official government documents and prescribed spelling systems in Southern Africa, the paper explores the challenges and possibilities of orthographic reforms allowing for mobility across language clusters, ethnicity, regional and national borders. I argue that this…

  13. An Appraisal of the Importance of Graduates' Language Skills and ERASMUS Experiences

    ERIC Educational Resources Information Center

    Mattern, Delfina

    2016-01-01

    This article discusses the importance of graduates' language skills and their European Regional Action Scheme for the Mobility of University Students (ERASMUS) experiences. The purpose of the research is to establish whether the potential benefits of ERASMUS participation for employability, particularly with regard to language skills, mean that…

  14. Mobile Learning and High-Profiling Language Education

    ERIC Educational Resources Information Center

    Vinther, Jane

    2012-01-01

    The number of students learning a second or foreign language and participating in instruction in languages other than English has been in decline for some time. This seems to be a general tendency across nations albeit for a variety of reasons idiosyncratic to the particular national conditions. This paper gives an account of a diversified…

  15. A Framework for International Student Participation in Postsecondary U.S. English Language Programs

    ERIC Educational Resources Information Center

    Colón, Valeriana

    2016-01-01

    Postsecondary English language education is a growing field in the United States. While there has been considerable research on international student mobility in higher education, there is limited research on the population's participation in U.S. English language programs (ELPs). This study examined literature in related fields to create a…

  16. Student-Produced Podcasts in Language Learning--Exploring Student Perceptions of Podcast Activities

    ERIC Educational Resources Information Center

    Phillips, Birgit

    2017-01-01

    Podcasts are a useful tool for developing speaking skills in language acquisition settings, particularly within the context of the emerging Mobile Assisted Language Learning (MALL). While much research has emphasized the effectiveness of teacher-produced podcasts, this study seeks to address the gap in knowledge on student-generated podcasts in…

  17. Engineering Commodifiable Workers: Language, Migration and the Governmentality of the Self

    ERIC Educational Resources Information Center

    Del Percio, Alfonso

    2018-01-01

    This article examines the strategies and forms of expertise on language and communication mobilized to engineer commodifiable migrant workers. Drawing on an ethnographic account of counselling practices in a state-run Italian job guidance centre for newly arrived migrants, I examine the calculations, tactics, and forms of expertise on language and…

  18. State of the App: A Taxonomy and Framework for Evaluating Language Learning Mobile Applications

    ERIC Educational Resources Information Center

    Rosell-Aguilar, Fernando

    2017-01-01

    The widespread growth in availability and use of smartphones and tablets has facilitated an unprecedented avalanche of new software applications with language learning and teaching capabilities. However, little has been published in terms of effective design and evaluation of language learning apps. This article reviews current research about the…

  19. An Open-Sourced and Interactive Ebook Development Program for Minority Languages

    ERIC Educational Resources Information Center

    Sheepy, Emily; Sundberg, Ross; Laurie, Anne

    2017-01-01

    According to Long (2014), genuine task-based pedagogy is centered around the real-world activities that learners need to complete using the target language. We are developing the OurStories mobile application to support learners and instructors of minority languages in the development of personally relevant, task-based learning resources. The…

  20. Profiling Mobile English Language Learners

    ERIC Educational Resources Information Center

    Byrne, Jason; Diem, Robert

    2014-01-01

    The purpose of this study was to use an app-embedded survey to profile language learner demographics. A total of 3,759 EFL language learners from primarily eight L1 backgrounds (French, German, Italian, Japanese, Korean, Russian, Spanish and Thai) responded to the survey embedded within a popular English grammar app. This app has over 500,000…

  1. Effectiveness of Mobile Devices on Vocabulary Learning: A Meta-Analysis

    ERIC Educational Resources Information Center

    Mahdi, Hassan Saleh

    2018-01-01

    Mobile devices are considered as the most widely used information and communication technologies. They have provided great advantages in language learning. This study reports a meta-analysis of the effectiveness of using mobile devices on vocabulary learning. A meta-analysis was conducted on research that compared the outcomes from students…

  2. A Study of Contextualised Mobile Information Delivery for Language Learning

    ERIC Educational Resources Information Center

    de Jong, Tim; Specht, Marcus; Koper, Rob

    2010-01-01

    Mobile devices offer unique opportunities to deliver learning content in authentic learning situations. Apart from being able to play various kinds of rich multimedia content, they offer new ways of tailoring information to the learner's situation or context. This paper presents the results of a study of mobile media delivery for language…

  3. From Particular to Popular: Facilitating EFL Mobile-Supported Cooperative Reading

    ERIC Educational Resources Information Center

    Lan, Yu-Ju; Sung, Yao-Ting; Chang, Kuo-En

    2013-01-01

    This paper reports the results of an action research-based study that adapted a mobile-supported cooperative reading system into regular English as a foreign language (EFL) classes at one Taiwanese elementary school. The current study was comprised of two stages: adaptation and evaluation. During the adaptation stage, a mobile-supported…

  4. Mobile Learning to Improve Writing in ESL Teaching

    ERIC Educational Resources Information Center

    Noriega, Heidy Selene Robles

    2016-01-01

    This article reports on the results of a study concerning the type of texts and their features produced by a student after using mobile technology as a support to improve the development of the students' writing skills in a second language. The Functional Systemic Linguistic (FSL), Genre Pedagogical Approach (GPA), and mobile learning concepts…

  5. Fostering an English Teaching Environment: Factors Influencing English as a Foreign Language Teachers' Adoption of Mobile Learning

    ERIC Educational Resources Information Center

    Jung, Hee-Jung

    2015-01-01

    The role of mobile technology has significantly increased and been emphasized in English education. However, research investigating EFL teachers' attitudes and behaviors related to mobile technology has been limited in descriptive aspects of the technology, leading to misunderstandings about EFL teachers' needs. Furthermore, many prior studies…

  6. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism

    PubMed Central

    Foe, Ian T.; Foster, Scott A.; Cheung, Stephanie K.; DeLuca, Steven Z.; Morgan, David O.; Toczyski, David P.

    2012-01-01

    SUMMARY Background Cells control progression through late mitosis by regulating Cdc20 and Cdh1, the two mitotic activators of the Anaphase Promoting Complex (APC). The control of Cdc20 protein levels during the cell cycle is not well understood. Results Here, we demonstrate that Cdc20 is degraded in budding yeast by multiple APC-dependent mechanisms. We find that the majority of Cdc20 turnover does not involve a second activator molecule, but instead depends on in cis Cdc20 autoubiquitination while it is bound to its activator-binding site on the APC core. Unlike in trans ubiquitination of Cdc20 substrates, the APC ubiquitinates Cdc20 independent of APC activation by Cdc20’s C-box. Cdc20 turnover by this intramolecular mechanism is cell cycle-regulated, contributing to the decline in Cdc20 levels that occurs after anaphase. Interestingly, high substrate levels in vitro significantly reduce Cdc20 autoubiquitination. Conclusion We show here that Cdc20 fluctuates through the cell cycle via a distinct form of APC-mediated ubiquitination. This in cis autoubiquitination may preferentially occur in early anaphase, following depletion of Cdc20 substrates. This suggests that distinct mechanisms are able to target Cdc20 for ubiquitination at different points during the cell cycle. PMID:22079111

  7. Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.

    PubMed

    Stephenson, Robert; Hosler, Marcus R; Gavande, Navnath S; Ghosh, Arun K; Weake, Vikki M

    2015-01-16

    Cdc7 is a serine-threonine kinase that phosphorylates components of the pre-replication complex during DNA replication initiation. Cdc7 is highly conserved, and Cdc7 orthologs have been characterized in organisms ranging from yeast to humans. Cdc7 is activated specifically during late G1/S phase by binding to its regulatory subunit, Dbf4. Drosophila melanogaster contains a Dbf4 ortholog, Chiffon, which is essential for chorion amplification in Drosophila egg chambers. However, no Drosophila ortholog of Cdc7 has yet been characterized. Here, we report the functional and biochemical characterization of a Drosophila ortholog of Cdc7. Co-expression of Drosophila Cdc7 and Chiffon is able to complement a growth defect in yeast containing a temperature-sensitive Cdc7 mutant. Cdc7 and Chiffon physically interact and can be co-purified from insect cells. Cdc7 phosphorylates the known Cdc7 substrates Mcm2 and histone H3 in vitro, and Cdc7 kinase activity is stimulated by Chiffon and inhibited by the Cdc7-specific inhibitor XL413. Drosophila egg chamber follicle cells deficient for Cdc7 have a defect in two types of DNA replication, endoreplication and chorion gene amplification. However, follicle cells deficient for Chiffon have a defect in chorion gene amplification but still undergo endocycling. Our results show that Cdc7 interacts with Chiffon to form a functional Dbf4-dependent kinase complex and that Cdc7 is necessary for DNA replication in Drosophila egg chamber follicle cells. Additionally, we show that Chiffon is a member of an expanding subset of DNA replication initiation factors that are not strictly required for endoreplication in Drosophila. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Infants with complex congenital heart diseases show poor short-term memory in the mobile paradigm at 3 months of age.

    PubMed

    Chen, Chao-Ying; Harrison, Tondi; Heathcock, Jill

    2015-08-01

    The purpose of this study was to examine learning, short-term memory and general development including cognitive, motor, and language domains in infants with Complex Congenital Heart Defects (CCDH). Ten infants with CCHD (4 males, 6 females) and 14 infants with typical development (TD) were examined at 3 months of age. The mobile paradigm, where an infant's leg is tethered to an overhead mobile, was used to evaluate learning and short-term memory. The Bayley Scales of Infant Development 3rd edition (Bayley-III) was used to evaluate general development in cognitive, motor, and language domains. Infants with CCHD and infants with TD both showed learning with significant increase in kicking rate (p<0.001) across periods of the mobile paradigm, but only infants with TD demonstrated short-term memory (p=0.017) in the mobile paradigm. There were no differences on cognitive, motor, and language development between infants with CCHD and infants with TD on the Bayley-III. Early assessment is necessary to guide targeted treatment in infants with CCHD. One-time assessment may fail to detect potential cognitive impairments during early infancy in infants with CCHD. Supportive intervention programs for infants with CCHD that focuses on enhancing short-term memory are recommended. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Complement-dependent cytotoxicity (CDC) to detect Anti-HLA antibodies: old but gold.

    PubMed

    Saito, Patrícia Keiko; Yamakawa, Roger Haruki; Pereira, Lucieni Christina Marques da Silva; da Silva, Waldir Veríssimo; Borelli, Sueli Donizete

    2014-07-01

    The criterion (gold) standard to detect anti-human leukocyte antigen (HLA) antibodies is the complement-dependent cytotoxicity (CDC) assay. Recently, more sensitive methods have been used for the same purpose. This study analyzed 70 serum samples of patients with end-stage renal disease using CDC, CDC with the addition of anti-human globulin (CDC-AHG), CDC with the addition of dithiothreitol (CDC-DTT), and the recent solid-phase immunoassay (SPI; Labscreen PRA) to detect anti-HLA antibodies. Mean percent panel reactive antibodies (PRA) detected by SPI was 37.5% (±34.2) higher than the values detected by the other methods. Comparative analyses revealed significant difference between CDC and CDC-AHG, and between CDC and SPI (P < 0.0001), but not between CDC-AHG and SPI (P = 0.8026). Although the CDC-AHG method is "old," its performance to detect anti-HLA antibodies in the samples analyzed was comparable to the SPI in the evaluation of percent class I PRA. © 2014 Wiley Periodicals, Inc.

  10. cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkin's lymphomas.

    PubMed

    Hernández, S; Hernández, L; Beà, S; Cazorla, M; Fernández, P L; Nadal, A; Muntané, J; Mallofré, C; Montserrat, E; Cardesa, A; Campo, E

    1998-04-15

    cdc25A, cdc25B, and cdc25C are a family of human phosphatases that activate the cyclin-dependent kinases at different points of the cell cycle. cdc25A and cdc25B have been shown to have oncogenic potential, and they have been identified as transcriptional targets of c-myc. To determine the role of cdc25 genes in the pathogenesis of human lymphomas and their possible correlation with c-myc deregulation, we have analyzed the expression of cdc25A, cdc25B, and cdc25C and c-myc genes in a series of 63 non-Hodgkin's lymphomas and 8 nonneoplastic lymphoid tissues. The mRNA levels of the three phosphatases in the nonneoplastic tissues were negative or negligible. cdc25B overexpression was detected in 35 tumors (56%). This overexpression was more frequently found in aggressive (81%) than in indolent lymphomas (36%; P < 0.01). cdc25B overexpression was also significantly associated with a higher proliferative activity of the tumors. No cdc25B gene amplification or rearrangements were detected by Southern blot analysis. A biallelic EcoRI polymorphism of cdc25B gene was identified with a similar distribution in patients with lymphoma and in a normal population. cdc25A was overexpressed in three aggressive lymphomas. No detectable cdc25C mRNA levels were seen in any of the tumors. c-myc was overexpressed in 43% of tumors, and it correlated significantly with the presence of cdc25B up-regulation. Twenty-six of 35 (74%) lymphomas with high levels of cdc25B mRNA also showed c-myc overexpression, whereas 27 of 28 (96%) tumors without detectable or with very low cdc25B expression also had undetectable c-myc levels (P < 0.0001). In addition, a significant linear correlation was found between the cdc25B and c-myc mRNA levels (r = 0.575, P < 0.001). These findings suggest that cdc25B overexpression in non-Hodkin's lymphoma may participate in the pathogenesis of aggressive variants, and it may cooperate with c-myc oncogene in the development of these tumors.

  11. cdc-25.4, a Caenorhabditis elegans Ortholog of cdc25, Is Required for Male Mating Behavior

    PubMed Central

    Oh, Sangmi; Kawasaki, Ichiro; Park, Jae-Hyung; Shim, Yhong-Hee

    2016-01-01

    Cell division cycle 25 (cdc25) is an evolutionarily conserved phosphatase that promotes cell cycle progression. Among the four cdc25 orthologs in Caenorhabditis elegans, we found that cdc-25.4 mutant males failed to produce outcrossed progeny. This was not caused by defects in sperm development, but by defects in male mating behavior. The cdc-25.4 mutant males showed various defects during male mating, including contact response, backing, turning, and vulva location. Aberrant turning behavior was the most prominent defect in the cdc-25.4 mutant males. We also found that cdc-25.4 is expressed in many neuronal cells throughout development. The turning defect in cdc-25.4 mutant males was recovered by cdc-25.4 transgenic expression in neuronal cells, suggesting that cdc-25.4 functions in neurons for male mating. However, the neuronal morphology of cdc-25.4 mutant males appeared to be normal, as examined with several neuronal markers. Also, RNAi depletion of wee-1.3, a C. elegans ortholog of Wee1/Myt1 kinase, failed to suppress the mating defects of cdc-25.4 mutant males. These findings suggest that, for successful male mating, cdc-25.4 does not target cell cycles that are required for neuronal differentiation and development. Rather, cdc-25.4 likely regulates noncanonical substrates in neuronal cells. PMID:27770028

  12. cdc-25.4, a Caenorhabditis elegans Ortholog of cdc25, Is Required for Male Mating Behavior.

    PubMed

    Oh, Sangmi; Kawasaki, Ichiro; Park, Jae-Hyung; Shim, Yhong-Hee

    2016-12-07

    Cell division cycle 25 (cdc25) is an evolutionarily conserved phosphatase that promotes cell cycle progression. Among the four cdc25 orthologs in Caenorhabditis elegans, we found that cdc-25.4 mutant males failed to produce outcrossed progeny. This was not caused by defects in sperm development, but by defects in male mating behavior. The cdc-25.4 mutant males showed various defects during male mating, including contact response, backing, turning, and vulva location. Aberrant turning behavior was the most prominent defect in the cdc-25.4 mutant males. We also found that cdc-25.4 is expressed in many neuronal cells throughout development. The turning defect in cdc-25.4 mutant males was recovered by cdc-25.4 transgenic expression in neuronal cells, suggesting that cdc-25.4 functions in neurons for male mating. However, the neuronal morphology of cdc-25.4 mutant males appeared to be normal, as examined with several neuronal markers. Also, RNAi depletion of wee-1.3, a C. elegans ortholog of Wee1/Myt1 kinase, failed to suppress the mating defects of cdc-25.4 mutant males. These findings suggest that, for successful male mating, cdc-25.4 does not target cell cycles that are required for neuronal differentiation and development. Rather, cdc-25.4 likely regulates noncanonical substrates in neuronal cells. Copyright © 2016 Oh et al.

  13. Functional characterization and cellular dynamics of the CDC-42 - RAC - CDC-24 module in Neurospora crassa.

    PubMed

    Araujo-Palomares, Cynthia L; Richthammer, Corinna; Seiler, Stephan; Castro-Longoria, Ernestina

    2011-01-01

    Rho-type GTPases are key regulators that control eukaryotic cell polarity, but their role in fungal morphogenesis is only beginning to emerge. In this study, we investigate the role of the CDC-42 - RAC - CDC-24 module in Neurospora crassa. rac and cdc-42 deletion mutants are viable, but generate highly compact colonies with severe morphological defects. Double mutants carrying conditional and loss of function alleles of rac and cdc-42 are lethal, indicating that both GTPases share at least one common essential function. The defects of the GTPase mutants are phenocopied by deletion and conditional alleles of the guanine exchange factor (GEF) cdc-24, and in vitro GDP-GTP exchange assays identify CDC-24 as specific GEF for both CDC-42 and RAC. In vivo confocal microscopy shows that this module is organized as membrane-associated cap that covers the hyphal apex. However, the specific localization patterns of the three proteins are distinct, indicating different functions of RAC and CDC-42 within the hyphal tip. CDC-42 localized as confined apical membrane-associated crescent, while RAC labeled a membrane-associated ring excluding the region labeled by CDC42. The GEF CDC-24 occupied a strategic position, localizing as broad apical membrane-associated crescent and in the apical cytosol excluding the Spitzenkörper. RAC and CDC-42 also display distinct localization patterns during branch initiation and germ tube formation, with CDC-42 accumulating at the plasma membrane before RAC. Together with the distinct cellular defects of rac and cdc-42 mutants, these localizations suggest that CDC-42 is more important for polarity establishment, while the primary function of RAC may be maintaining polarity. In summary, this study identifies CDC-24 as essential regulator for RAC and CDC-42 that have common and distinct functions during polarity establishment and maintenance of cell polarity in N. crassa.

  14. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs approved...

  15. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs approved...

  16. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs approved...

  17. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs approved...

  18. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs approved...

  19. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of any...

  20. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of any...

  1. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of any...

  2. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of any...

  3. Facts about Botulism

    MedlinePlus

    ... Search Controls Search Form Controls Search The CDC Cancel Submit Search The CDC CDC A-Z Index ... Search Controls Search Form Controls Search The CDC Cancel Submit Search The CDC Page Not Found Note: ...

  4. Utilization of a Text and Translation Application for Communication With a Foreign Deaf Family: A Call for Validation of This Technology-A Case Report.

    PubMed

    Fernandez, Patrick G; Brockel, Megan A; Lipscomb, Lisa L; Ing, Richard J; Tailounie, Muayyad

    2017-07-15

    Effective communication with patients is essential to quality care. Obviously, language barriers significantly impact this and can increase the risk of poor patient outcomes. Smartphones and mobile health technology are valuable resources that are beginning to break down language barriers in health care. We present a case of a challenging language barrier where successful perioperative communication was achieved using mobile technology. Although quite beneficial, use of technology that is not validated exposes providers to unnecessary medicolegal risk. We hope to highlight the need for validation of such technology to ensure that these tools are an effective way to accurately communicate with patients in the perioperative setting.

  5. The Global Geek: Language Training for IT Students' Study Abroad in Austria and Germany

    ERIC Educational Resources Information Center

    Cliver, Gwyneth E.; Khazanchi, Deepak

    2011-01-01

    Recognizing the global role of information technology, this article describes a USDOE-funded transatlantic mobility program in the area of IT project management. The project enhances intercultural as well as German language skills and promotes a mutual understanding of EU and US cultures. The relationship between IT and German-language programs…

  6. MALL with WordBricks--Building Correct Sentences Brick by Brick

    ERIC Educational Resources Information Center

    Purgina, Marina; Mozgovoy, Maxim; Ward, Monica

    2017-01-01

    Mobile-Assisted Language Learning (MALL) use is increasing and it is good to be able to provide language learners with new resources to enhance their language learning experience. One such resource is WordBricks, a non-commercial, educational app that facilitates the learning and reinforcement of grammar rules. It uses bricks and connectors of…

  7. Task-Based Language Teaching with Smartphones: A Case Study in Pakistan

    ERIC Educational Resources Information Center

    Rashid, Shaista; Cunningham, Una; Watson, Kevin

    2017-01-01

    Integration of technology in task-based language teaching (TBLT) has long been a source of attraction for language teachers (Pierson, 2015). In the case of developing countries, such as Pakistan, mobile phones are the modern form of technology commonly available at low cost to individuals as well as institutions. The present descriptive case study…

  8. VoIM-Mediated Cooperative Tasks for English Language Learners

    ERIC Educational Resources Information Center

    Chinnery, George M.

    2008-01-01

    The use of telephones--even mobile phones--in language learning is not unique (see Chinnery 2006). The literature is also The literature is also replete with imaginative ideas on how to apply Internet chat software like instant messengers (IM) to language learning. A more recent technological development of use to educators is Internet telephony,…

  9. Spoken Language Comprehension of Phrases, Simple and Compound-Active Sentences in Non-Speaking Children with Severe Cerebral Palsy

    ERIC Educational Resources Information Center

    Geytenbeek, Joke J. M.; Heim, Margriet J. M.; Knol, Dirk L.; Vermeulen, R. Jeroen; Oostrom, Kim J.

    2015-01-01

    Background Children with severe cerebral palsy (CP) (i.e. "non-speaking children with severely limited mobility") are restricted in many domains that are important to the acquisition of language. Aims To investigate comprehension of spoken language on sentence type level in non-speaking children with severe CP. Methods & Procedures…

  10. Design and Implementation of BusinessApp, a MALL Application to Make Successful Business Presentations

    ERIC Educational Resources Information Center

    Calle-Martínez, Cristina; Yanes, Lourdes Pomposo; Pareja-Lora, Antonio

    2016-01-01

    Little by little, (or, simply, MALL) is taking force in the field of education, as it supports language blended learning and language learning ubiquity. The study presented here belongs in the Social Ontology-based Cognitively Augmented Language Learning Mobile Environment (SO-CALL-ME) research project, whose final aim is to design and create…

  11. Learning English Using Children's Stories in Mobile Devices

    ERIC Educational Resources Information Center

    Cavus, Nadire; Ibrahim, Dogan

    2017-01-01

    The topic of this paper is to describe the development of an interactive application that can be used in teaching English as a second language using children's stories in mobile devices. The aim of this experimental study has been to find out the potential of using the developed interactive mobile application in improving the learning skills such…

  12. The Effect of Mobile Learning on Students' Achievement and Conversational Skills

    ERIC Educational Resources Information Center

    Elfeky, Abdellah Ibrahim Mohammed; Masadeh, Thouqan Saleem Yakoub

    2016-01-01

    The present study aimed to examine the effect of Mobile Learning, which is a kind of E-learning that uses mobile devices, on the development of the academic achievement and conversational skills of English language specialty students at Najran University. The study used the quasi-experimental approach. Participants consisted of (50) students who…

  13. Mobile Blogs in Language Learning: Making the Most of Informal and Situated Learning Opportunities

    ERIC Educational Resources Information Center

    Comas-Quinn, Anna; Mardomingo, Raquel; Valentine, Chris

    2009-01-01

    The application of mobile technologies to learning has the potential to facilitate the active participation of learners in the creation and delivery of content. Mobile technologies can also provide a powerful connection between a variety of formal and informal learning contexts and can help to build a community of learners. However these versatile…

  14. English Language Learners' Reading Self-Efficacy and Achievement Using 1:1 Mobile Learning Devices

    ERIC Educational Resources Information Center

    Walters, Jennifer L.

    2012-01-01

    Handheld technology devices allow users to be mobile and access the Internet, personal data, and third-party content applications in many different environments at the users' convenience. The explosion of these mobile learning devices around the globe has led adults to value them for communication, productivity, and learning. Outside of the school…

  15. Patterns and Effectiveness of Mobile Device Usage by Japanese Undergraduates for L2 Acquisition Purposes

    ERIC Educational Resources Information Center

    Pagel, James W.; Lambacher, Stephen G.

    2014-01-01

    Mobile technologies, such as smartphones and tablets, are rapidly gaining popularity as an effective means to enhance foreign language learning. However, does the incorporation of these mobile devices really benefit the learner or simply satisfy the instructor's need to be innovative and ahead of the learning curve? The present study seeks to…

  16. Effects of Using Mobile Devices on English Listening Diversity and Speaking for EFL Elementary Students

    ERIC Educational Resources Information Center

    Hwang, Wu-Yuin; Huang, Yueh-Min; Shadiev, Rustam; Wu, Sheng-Yi; Chen, Shu-Lin

    2014-01-01

    This study designed learning activities supported by a mobile learning system for students to develop listening and speaking skills in English as a foreign language (EFL). How students perceive learning activities and a mobile learning system were examined in this study. Additionally, how different practices relate to students' language…

  17. Towards Situation Driven Mobile Tutoring System for Learning Languages and Communication Skills: Application to Users with Specific Needs

    ERIC Educational Resources Information Center

    Khemaja, Maha; Taamallah, Aroua

    2016-01-01

    Current advances in portable devices and wireless technologies had drastically impacted mobile and pervasive computing development and use. Nowadays, mobile and or pervasive applications, are increasingly being used to support users' everyday activities. These apps either distributed or standalone are characterized by the variability of the…

  18. Mobile Apps to Support and Assess Foreign Language Learning

    ERIC Educational Resources Information Center

    Berns, Anke; Palomo-Duarte, Manuel; Dodero, Juan Manuel; Ruiz-Ladrón, Juan Miguel; Márquez, Andrea Calderón

    2015-01-01

    In the last two decades there have been many attempts to integrate all kinds of mobile devices and apps to support formal as well as informal learning processes. However, most of the available apps still support mainly individual learning, using mobile devices to deliver content rather than providing learners with the opportunity to interact with…

  19. Mobile English Learning: An Evidence-Based Study with Fifth Graders

    ERIC Educational Resources Information Center

    Sandberg, Jacobijn; Maris, Marinus; de Geus, Kaspar

    2011-01-01

    Three groups participated in a study on the added value of mobile technology for learning English as a second language for primary school students. The first group had classroom lessons in English about zoo animals and their characteristics. The second group took classroom lessons and worked with a mobile application on location in a public zoo.…

  20. Injuries and Mass Casualty Events

    MedlinePlus

    ... Search Controls Search Form Controls Search The CDC Cancel Submit Search The CDC CDC A-Z Index ... Search Controls Search Form Controls Search The CDC Cancel Submit Search The CDC Page Not Found Note: ...

  1. [Expression levels of Cdc2 and Cdc25A mRNA in cattle, yak, and cattle-yak testis].

    PubMed

    Dong, Li-Yan; Li, Qi-Fa; Qu, Xu-Guang; Li, Yin-Xia; Li, Xin-Fu; Hu, Hong-Tao; Xie, Zhuang

    2009-05-01

    The infertility of cattle-yak, which is the hybrid offspring of cattle and yak, is a difficult problem in crossbreeding and improvement of yak. Cdc2 and Cdc25A are the key genes of meiosis. The decline of their expression levels will cause the spermatogenesis failure and lead to infertility. Therefore, this study was conducted to study the relationship between the infertility of cattle-yak and the expression levels of Cdc2/Cdc25A genes. The expression profiles were obtained by RT-PCR. Cdc2 and Cdc25A genes were widely expressed in many tissues, which confirmed their important role in cell division and the progression of cell cycle. Real-time quantitative PCR analysis indicated that the expression levels of Cdc2 and Cdc25A in cattle and yak testis were higher than those in cattle-yak (P<0.05). Therefore, low expression levels of Cdc2 and Cdc25A genes may have a relationship with the infertility of cattle-yak.

  2. The Cdc48 Protein and Its Cofactor Vms1 Are Involved in Cdc13 Protein Degradation*

    PubMed Central

    Baek, Guem Hee; Cheng, Haili; Kim, Ikjin; Rao, Hai

    2012-01-01

    Vms1 is a newly identified Cdc48-binding protein. The biological function of Vms1 remains obscure. Here, we show that both Cdc48 and Vms1, but not Cdc48 cofactors Ufd1 and Ufd2, are crucial for the degradation of Cdc13, a telomere regulator. Interestingly, both autophagy and the proteasome are involved in Cdc13 turnover. Toxicity associated with accumulation of large amounts of Cdc13 in vms1Δ or autophagy mutants underscores the significance of the proteolytic regulation of Cdc13. Because few ubiquitylated yeast proteins are known to be degraded by autophagy under non-stress conditions, the identification of Cdc13 as a target of autophagy provides a valuable tool to unravel the mechanism of autophagy-mediated selective protein degradation. PMID:22718752

  3. Blastomyces dermatitidis septins CDC3, CDC10, and CDC12 impact the morphology of yeast and hyphae, but are not required for the phase transition.

    PubMed

    Marty, Amber J; Gauthier, Gregory M

    2013-01-01

    Blastomyces dermatitidis, the etiologic agent of blastomycosis, belongs to a group of thermally dimorphic fungi that change between mold (22°C) and yeast (37°C) in response to temperature. The contribution of structural proteins such as septins to this phase transition in these fungi remains poorly understood. Septins are GTPases that serve as a scaffold for proteins involved with cytokinesis, cell polarity, and cell morphology. In this study, we use a GFP sentinel RNA interference system to investigate the impact of CDC3, CDC10, CDC12, and ASPE on the morphology and phase transition of B. dermatitidis. Targeting CDC3, CDC10, and CDC12 by RNA interference resulted in yeast with aberrant morphology at 37°C with defects in cytokinesis. Downshifting the temperature to 22°C promoted the conversion to the mold phase, but did not abrogate the morphologic defects. CDC3, CDC10, and CDC12 knockdown strains grew as mold with curved, thickened hyphae. Knocking down ASPE transcript did not alter morphology of yeast at 37°C or mold at 22°C. Following an increase in temperature from 22°C to 37°C, all septin knockdown strains were able to revert to yeast. In conclusion, CDC3, CDC10, and CDC12 septin- encoding genes are required for proper morphology of yeast and hyphae, but are dispensable for the phase transition.

  4. Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions*

    PubMed Central

    Jiang, Yiqun; Bernard, Denzil; Yu, Yanke; Xie, Yehua; Zhang, Tao; Li, Yanyan; Burnett, Joseph P.; Fu, Xueqi; Wang, Shaomeng; Sun, Duxin

    2010-01-01

    Hsp90 requires cochaperone Cdc37 to load its clients to the Hsp90 superchaperone complex. The purpose of this study was to utilize split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) bioluminescence to study the full-length human Hsp90-Cdc37 complex and to identity critical residues and their contributions for Hsp90/Cdc37 interaction in living cells. SRL-PFAC showed that full-length human Hsp90/Cdc37 interaction restored dramatically high luciferase activity through Hsp90-Cdc37-assisted complementation of the N and C termini of luciferase (compared with the set of controls). Immunoprecipitation confirmed that the expressed fusion proteins (NRL-Hsp90 and Cdc37-CRL) preserved their ability to interact with each other and also with native Hsp90 or Cdc37. Molecular dynamic simulation revealed several critical residues in the two interaction patches (hydrophobic and polar) at the interface of Hsp90/Cdc37. Mutagenesis confirmed the critical residues for Hsp90-Cdc37 complex formation. SRL-PFAC bioluminescence evaluated the contributions of these critical residues in Hsp90/Cdc37 interaction. The results showed that mutations in Hsp90 (Q133A, F134A, and A121N) and mutations in Cdc37 (M164A, R167A, L205A, and Q208A) reduced the Hsp90/Cdc37 interaction by 70–95% as measured by the resorted luciferase activity through Hsp90-Cdc37-assisted complementation. In comparison, mutations in Hsp90 (E47A and S113A) and a mutation in Cdc37 (A204E) decreased the Hsp90/Cdc37 interaction by 50%. In contrast, mutations of Hsp90 (R46A, S50A, C481A, and C598A) and mutations in Cdc37 (C54S, C57S, and C64S) did not change Hsp90/Cdc37 interactions. The data suggest that single amino acid mutation in the interface of Hsp90/Cdc37 is sufficient to disrupt its interaction, although Hsp90/Cdc37 interactions are through large regions of hydrophobic and polar interactions. These findings provides a rationale to develop inhibitors for disruption of the Hsp90/Cdc37 interaction. PMID:20413594

  5. Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions.

    PubMed

    Jiang, Yiqun; Bernard, Denzil; Yu, Yanke; Xie, Yehua; Zhang, Tao; Li, Yanyan; Burnett, Joseph P; Fu, Xueqi; Wang, Shaomeng; Sun, Duxin

    2010-07-02

    Hsp90 requires cochaperone Cdc37 to load its clients to the Hsp90 superchaperone complex. The purpose of this study was to utilize split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) bioluminescence to study the full-length human Hsp90-Cdc37 complex and to identity critical residues and their contributions for Hsp90/Cdc37 interaction in living cells. SRL-PFAC showed that full-length human Hsp90/Cdc37 interaction restored dramatically high luciferase activity through Hsp90-Cdc37-assisted complementation of the N and C termini of luciferase (compared with the set of controls). Immunoprecipitation confirmed that the expressed fusion proteins (NRL-Hsp90 and Cdc37-CRL) preserved their ability to interact with each other and also with native Hsp90 or Cdc37. Molecular dynamic simulation revealed several critical residues in the two interaction patches (hydrophobic and polar) at the interface of Hsp90/Cdc37. Mutagenesis confirmed the critical residues for Hsp90-Cdc37 complex formation. SRL-PFAC bioluminescence evaluated the contributions of these critical residues in Hsp90/Cdc37 interaction. The results showed that mutations in Hsp90 (Q133A, F134A, and A121N) and mutations in Cdc37 (M164A, R167A, L205A, and Q208A) reduced the Hsp90/Cdc37 interaction by 70-95% as measured by the resorted luciferase activity through Hsp90-Cdc37-assisted complementation. In comparison, mutations in Hsp90 (E47A and S113A) and a mutation in Cdc37 (A204E) decreased the Hsp90/Cdc37 interaction by 50%. In contrast, mutations of Hsp90 (R46A, S50A, C481A, and C598A) and mutations in Cdc37 (C54S, C57S, and C64S) did not change Hsp90/Cdc37 interactions. The data suggest that single amino acid mutation in the interface of Hsp90/Cdc37 is sufficient to disrupt its interaction, although Hsp90/Cdc37 interactions are through large regions of hydrophobic and polar interactions. These findings provides a rationale to develop inhibitors for disruption of the Hsp90/Cdc37 interaction.

  6. MAGNA (Materially and Geometrically Nonlinear Analysis). Part I. Finite Element Analysis Manual.

    DTIC Science & Technology

    1982-12-01

    provided for operating the program, modifying storage caoacity, preparing input data, estimating computer run times , and interpreting the output...7.1.3 Reserved File Names 7.1.16 7.1.4 Typical Execution Times on CDC Computers 7.1.18 7.2 CRAY PROGRAM VERSION 7.2.1 7.2.1 Job Control Language 7.2.1...7.2.2 Modification of Storage Capacity 7.2.8 7.2.3 Execution Times on the CRAY-I Computer 7.2.12 7.3 VAX PROGRAM VERSION 7.3.1 8 INPUT DATA 8.0.1 8.1

  7. User's guide for FRMOD, a zero dimensional FRM burn code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Driemeryer, D.; Miley, G.H.

    1979-10-15

    The zero-dimensional FRM plasma burn code, FRMOD is written in the FORTRAN language and is currently available on the Control Data Corporation (CDC) 7600 computer at the Magnetic Fusion Energy Computer Center (MFECC), sponsored by the US Department of Energy, in Livermore, CA. This guide assumes that the user is familiar with the system architecture and some of the utility programs available on the MFE-7600 machine, since online documentation is available for system routines through the use of the DOCUMENT utility. Users may therefore refer to it for answers to system related questions.

  8. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype.

    PubMed

    Yao, Likun; Chen, Jing; Wu, Xiaotong; Jia, Shunji; Meng, Anming

    2017-11-01

    Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC) forming on DNA replication origins in eukaryotes. Recessive mutations in ORC1, ORC4, ORC6, CDT1 or CDC6 of the preRC in human cause Meier-Gorlin syndrome (MGS) that is characterized by impaired post-natal growth, short stature and microcephaly. However, vertebrate models of MGS have not been reported. Through N-ethyl-N-nitrosourea mutagenesis and Cas9 knockout, we generate several cdc6 mutant lines in zebrafish. Loss-of-function mutations of cdc6, as manifested by cdc6tsu4305 and cdc6tsu7cd mutants, lead to embryonic lethality due to cell cycle arrest at the S phase and extensive apoptosis. Embryos homozygous for a cdc6 hypomorphic mutation, cdc6tsu21cd, develop normally during embryogenesis. Later on, compared with their wild-type (WT) siblings, cdc6tsu21cd mutant fish show growth retardation, and their body weight and length in adulthood are greatly reduced, which resemble human MGS. Surprisingly, cdc6tsu21cd mutant fish become males with a short life and fail to mate with WT females, suggesting defective reproduction. Overexpression of Cdc6 mutant forms, which mimic human CDC6(T323R) mutation found in a MGS patient, in zebrafish cdc6tsu4305 mutant embryos partially represses cell death phenotype, suggesting that the human CDC6(T323R) mutation is a hypomorph. cdc6tsu21cd mutant fish will be useful to detect more tissue defects and develop medical treatment strategies for MGS patients. © The Author 2017. Published by Oxford University Press.

  9. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype

    PubMed Central

    Yao, Likun; Chen, Jing; Wu, Xiaotong; Jia, Shunji; Meng, Anming

    2017-01-01

    Abstract Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC) forming on DNA replication origins in eukaryotes. Recessive mutations in ORC1, ORC4, ORC6, CDT1 or CDC6 of the preRC in human cause Meier-Gorlin syndrome (MGS) that is characterized by impaired post-natal growth, short stature and microcephaly. However, vertebrate models of MGS have not been reported. Through N-ethyl-N-nitrosourea mutagenesis and Cas9 knockout, we generate several cdc6 mutant lines in zebrafish. Loss-of-function mutations of cdc6, as manifested by cdc6tsu4305 and cdc6tsu7cd mutants, lead to embryonic lethality due to cell cycle arrest at the S phase and extensive apoptosis. Embryos homozygous for a cdc6 hypomorphic mutation, cdc6tsu21cd, develop normally during embryogenesis. Later on, compared with their wild-type (WT) siblings, cdc6tsu21cd mutant fish show growth retardation, and their body weight and length in adulthood are greatly reduced, which resemble human MGS. Surprisingly, cdc6tsu21cd mutant fish become males with a short life and fail to mate with WT females, suggesting defective reproduction. Overexpression of Cdc6 mutant forms, which mimic human CDC6(T323R) mutation found in a MGS patient, in zebrafish cdc6tsu4305 mutant embryos partially represses cell death phenotype, suggesting that the human CDC6(T323R) mutation is a hypomorph. cdc6tsu21cd mutant fish will be useful to detect more tissue defects and develop medical treatment strategies for MGS patients. PMID:28985365

  10. Updates on human papillomavirus and genital warts and counseling messages from the 2010 Sexually Transmitted Diseases Treatment Guidelines.

    PubMed

    Dunne, Eileen F; Friedman, Allison; Datta, S Deblina; Markowitz, Lauri E; Workowski, Kimberly A

    2011-12-01

    In April 2009, experts on sexually transmitted diseases (STDs) were convened to review updates on STD prevention and treatment in preparation for the revision of the Centers for Disease Control and Prevention (CDC) STD Treatment Guidelines. At this meeting, there was a discussion of important updates on human papillomavirus (HPV), genital warts, and cervical cancer screening. Key questions were identified with assistance from an expert panel, and systematic reviews of the literature were conducted searching the English-language literature of the PubMed computerized database (US National Library of Medicine). The available evidence was reviewed, and new information was incorporated in the 2010 CDC STD Treatment Guidelines. Two HPV vaccines are now available, the quadrivalent HPV vaccine and the bivalent HPV vaccine; either vaccine is recommended routinely for girls aged 11 or 12 years. The quadrivalent HPV vaccine may be given to boys and men aged 9-26 years. A new patient-applied treatment option for genital warts, sinecatechins 15% ointment, is available and recommended for treatment of external genital warts. This product is a mixture of active ingredients (catechins) from green tea. Finally, updated counseling guidelines and messages about HPV, genital warts, and cervical cancer are included. This manuscript highlights updates to the 2010 CDC STD Treatment Guidelines for HPV and genital warts. Important additions to the 2010 STD Treatment Guidelines include information on prophylactic HPV vaccine recommendations, new patient-applied treatment options for genital warts, and counseling messages for patients on HPV, genital warts, cervical cancer screening, and HPV tests.

  11. Carbide-derived carbon (CDC) linear actuator properties in combination with conducting polymers

    NASA Astrophysics Data System (ADS)

    Kiefer, Rudolf; Aydemir, Nihan; Torop, Janno; Kilmartin, Paul A.; Tamm, Tarmo; Kaasik, Friedrich; Kesküla, Arko; Travas-Sejdic, Jadranka; Aabloo, Alvo

    2014-03-01

    Carbide-derived Carbon (CDC) material is applied for super capacitors due to their nanoporous structure and their high charging/discharging capability. In this work we report for the first time CDC linear actuators and CDC combined with polypyrrole (CDC-PPy) in ECMD (Electrochemomechanical deformation) under isotonic (constant force) and isometric (constant length) measurements in aqueous electrolyte. CDC-PPy actuators showing nearly double strain under cyclic voltammetric and square wave potential measurements in comparison to CDC linear actuators. The new material is investigated by SEM (scanning electron microscopy) and EDX (energy dispersive X-ray analysis) to reveal how the conducting polymer layer and the CDC layer interfere together.

  12. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.

    PubMed

    Gould, K L; Burns, C G; Feoktistova, A; Hu, C P; Pasion, S G; Forsburg, S L

    1998-07-01

    A mutation within the Schizosaccharomyces pombe cdc24(+) gene was identified previously in a screen for cell division cycle mutants and the cdc24(+) gene was determined to be essential for S phase in this yeast. We have isolated the cdc24(+) gene by complementation of a new temperature-sensitive allele of the gene, cdc24-G1. The DNA sequence predicts the presence of an open reading frame punctuated by six introns which encodes a pioneer protein of 58 kD. A cdc24 null mutant was generated by homologous recombination. Haploid cells lacking cdc24(+) are inviable, indicating that cdc24(+) is an essential gene. The transcript of cdc24(+) is present at constant levels throughout the cell cycle. Cells lacking cdc24(+) function show a checkpoint-dependent arrest with a 2N DNA content, indicating a block late in S phase. Arrest is accompanied by a rapid loss of viability and chromosome breakage. An S. pombe homolog of the replicative DNA helicase DNA2 of S. cerevisiae suppresses cdc24. These results suggest that Cdc24p plays a role in the progression of normal DNA replication and is required to maintain genomic integrity.

  13. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.

    PubMed Central

    Gould, K L; Burns, C G; Feoktistova, A; Hu, C P; Pasion, S G; Forsburg, S L

    1998-01-01

    A mutation within the Schizosaccharomyces pombe cdc24(+) gene was identified previously in a screen for cell division cycle mutants and the cdc24(+) gene was determined to be essential for S phase in this yeast. We have isolated the cdc24(+) gene by complementation of a new temperature-sensitive allele of the gene, cdc24-G1. The DNA sequence predicts the presence of an open reading frame punctuated by six introns which encodes a pioneer protein of 58 kD. A cdc24 null mutant was generated by homologous recombination. Haploid cells lacking cdc24(+) are inviable, indicating that cdc24(+) is an essential gene. The transcript of cdc24(+) is present at constant levels throughout the cell cycle. Cells lacking cdc24(+) function show a checkpoint-dependent arrest with a 2N DNA content, indicating a block late in S phase. Arrest is accompanied by a rapid loss of viability and chromosome breakage. An S. pombe homolog of the replicative DNA helicase DNA2 of S. cerevisiae suppresses cdc24. These results suggest that Cdc24p plays a role in the progression of normal DNA replication and is required to maintain genomic integrity. PMID:9649516

  14. cdc-25.2, a C. elegans ortholog of cdc25, is required to promote oocyte maturation.

    PubMed

    Kim, Jiyoung; Kawasaki, Ichiro; Shim, Yhong-Hee

    2010-03-15

    Cdc25 is an evolutionarily conserved protein phosphatase that promotes progression through the cell cycle. Some metazoans have multiple isoforms of Cdc25, which have distinct functions and different expression patterns during development. C. elegans has four cdc-25 genes. cdc-25.1 is required for germline mitotic proliferation. To determine if the other members of the cdc-25 family also contribute to regulation of cell division in the germ line, we examined phenotypes of loss-of-function mutants of the other cdc-25 family genes. We found that cdc-25.2 is also essential for germline development. cdc-25.2 homozygous mutant hermaphrodites exhibited sterility as a result of defects in oogenesis: mutant oocytes were arrested as endomitotic oocytes that were not fertilized successfully. Spermatogenesis and male germline development were not affected. Through genetic interaction studies, we found that CDC-25.2 functions upstream of maturation-promoting factor containing CDK-1 and CYB-3 to promote oocyte maturation by counteracting function of WEE-1.3. We propose that cdc-25 family members function as distinct but related cell cycle regulators to control diverse cell cycles in C. elegans germline development.

  15. Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum.

    PubMed

    Liu, Huiquan; Zhang, Shijie; Ma, Jiwen; Dai, Yafeng; Li, Chaohui; Lyu, Xueliang; Wang, Chenfang; Xu, Jin-Rong

    2015-06-01

    Eukaryotic cell cycle involves a number of protein kinases important for the onset and progression through mitosis, most of which are well characterized in the budding and fission yeasts and conserved in other fungi. However, unlike the model yeast and filamentous fungi that have a single Cdc2 essential for cell cycle progression, the wheat scab fungus Fusarium graminearum contains two CDC2 orthologs. The cdc2A and cdc2B mutants had no obvious defects in growth rate and conidiation but deletion of both of them is lethal, indicating that these two CDC2 orthologs have redundant functions during vegetative growth and asexual reproduction. However, whereas the cdc2B mutant was normal, the cdc2A mutant was significantly reduced in virulence and rarely produced ascospores. Although deletion of CDC2A had no obvious effect on the formation of penetration branches or hyphopodia, the cdc2A mutant was limited in the differentiation and growth of infectious growth in wheat tissues. Therefore, CDC2A plays stage-specific roles in cell cycle regulation during infectious growth and sexual reproduction. Both CDC2A and CDC2B are constitutively expressed but only CDC2A was up-regulated during plant infection and ascosporogenesis. Localization of Cdc2A- GFP to the nucleus but not Cdc2B-GFP was observed in vegetative hyphae, ascospores, and infectious hyphae. Complementation assays with chimeric fusion constructs showed that both the N- and C-terminal regions of Cdc2A are important for its functions in pathogenesis and ascosporogenesis but only the N-terminal region is important for its subcellular localization. Among the Sordariomycetes, only three Fusarium species closely related to F. graminearum have two CDC2 genes. Furthermore, F. graminearum uniquely has two Aurora kinase genes and one additional putative cyclin gene, and its orthologs of CAK1 and other four essential mitotic kinases in the budding yeast are dispensable for viability. Overall, our data indicate that cell cycle regulation is different between vegetative and infectious hyphae in F. graminearum and Cdc2A, possibly by interacting with a stage-specific cyclin, plays a more important role than Cdc2B during ascosporogenesis and plant infection.

  16. Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents.

    PubMed

    Cheng, An Ning; Jiang, Shih Sheng; Fan, Chi-Chen; Lo, Yu-Kang; Kuo, Chan-Yen; Chen, Chung-Hsing; Liu, Ying-Lan; Lee, Chun-Chung; Chen, Wei-Shone; Huang, Tze-Sing; Wang, Tao-Yeuan; Lee, Alan Yueh-Luen

    2013-09-01

    Cdc7-Dbf4 kinase (Dbf4-dependent kinase, DDK) is an essential factor of DNA replication and DNA damage response (DDR), which is associated with tumorigenesis. However, Cdc7 expression has never been associated to the outcome of oral squamous cell carcinoma (OSCC) patients, and the mechanism underlying cancer cell survival mediated by Cdc7 remains unclear. The Cdc7 protein expression of 105 OSCC tumor and 30 benign tissues was examined by immunohistochemistry assay. Overall survival rates of 80 OSCC patients were measured using Kaplan-Meier estimates and the log-rank tests. Cdc7 overexpression by adenovirus system was used to scrutinize the underlying mechanism contributed to cancer cell survival upon DDR. In silico analysis showed that increased Cdc7 is a common feature of cancer. Cdc7 overexpression was found in 96 of 105 (91.4%) studied cases of OSCC patients. Patients with higher Cdc7 expression, either categorized into two groups: Cdc7 high expression (2+ to 3+) versus Cdc7 low expression (0 to 1+) [hazard ratios (HR)=2.6; 95% confidence interval (CI)=1.28-5.43; P=0.0087] or four groups (0 to 3+) [HR=1.71; 95% CI=1.20-2.44; P=0.0032], exhibited a poorer outcome. Multivariate analysis showed that Cdc7 is an independent marker for survival prediction. Overexpressed Cdc7 inhibits genotoxin-induced apoptosis to increase the survival of cancer cells. In summary, Cdc7 expression, which is universally upregulated in cancer, is an independent prognostic marker of OSCC. Cdc7 inhibits genotoxin-induced apoptosis and increases survival in cancer cells upon DDR, suggesting that high expression of Cdc7 enhances the resistance to chemotherapy. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  17. CDC25AQ110del: A Novel Cell Division Cycle 25A Isoform Aberrantly Expressed in Non-Small Cell Lung Cancer

    PubMed Central

    Younis, Rania H.; Cao, Wei; Lin, Ruxian; Xia, Ronghui; Liu, Zhenqiu; Edelman, Martin J.; Mei, Yuping; Mao, Li; Ren, Hening

    2012-01-01

    Objective Lung cancer remains number one cause of cancer related deaths worldwide. Cell cycle deregulation plays a major role in the pathogenesis of Non-Small Cell Lung Cancer (NSCLC). CDC25A represents a critical cell cycle regulator that enhances cell cycle progression. In this study we aimed to investigate the role of a novel CDC25A transcriptional variant, CDC25AQ110del, on the regulation of the CDC25A protein, and its impact on prognosis of NSCLC patients. Methodology/Principal Findings Here we report a novel CDC25A transcript variant with codon 110 (Glutamine) deletion, that we termed CDC25AQ110del in NSCLC cells. In 9 (75%) of the 12 NSCLC cell lines, CDC25AQ110del expression accounted for more than 20% of the CDC25A transcripts. Biological effects of CDC25AQ110del were investigated in H1299 and HEK-293F cells using UV radiation, flowcytometry, cyclohexamide treatment, and confocal microscopy. Compared to CDC25Awt, CDC25AQ110del protein had longer half-life; cells expressing CDC25AQ110del were more resistant to UV irradiation and showed more mitotic activity. Taqman-PCR was used to quantify CDC25AQ110del expression levels in 88 primary NSCLC tumor/normal tissue pairs. In patients with NSCLC, Kaplan Meier curves showed tumors expressing higher levels of CDC25AQ110del relative to the adjacent lung tissues to have significantly inferior overall survival (P = .0018). Significance Here we identified CDC25AQ110del as a novel transcriptional variant of CDC25A in NSCLC. The sequence-specific nature of the abnormality could be a prognostic indicator in NSCLC patients as well as a candidate target for future therapeutic strategies. PMID:23071577

  18. Certified In-lined Reference Monitoring on .NET

    DTIC Science & Technology

    2006-06-01

    Introduction Language -based approaches to computer security have employed two major strategies for enforcing security policies over untrusted programs. • Low...automatically verify IRM’s using a static type-checker. Mobile (MOnitorable BIL with Effects) is an exten- sion of BIL (Baby Intermediate Language ) [15], a...AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES Proceedings of the 2006 Programming Languages and

  19. Highly Effective Teachers of Latino English Language Learners: Knowledge, Skills, and Dispositions That Lead to Improved Language Acquisition and Student Achievement

    ERIC Educational Resources Information Center

    Moore, Wendy V.

    2016-01-01

    It is predicted that Hispanic school-aged children will outnumber non-Hispanic white students in public schools by 2050 (Wolf, Herman, & Dietel, 2010). While the number of Latino English language learners (ELLs) continues to grow, their educational achievement remains problematic. Data reveal that ELL dropout, mobility, and poverty rates are…

  20. Using Smart Phones in Language Learning--A Pilot Study to Turn CALL into MALL

    ERIC Educational Resources Information Center

    Kétyi, András

    2013-01-01

    The popularity of smart phones has increased enormously in the last few years. Because of the increasing penetration of these devices and the above-average willingness of our students using new tools and devices in language courses, we decided to design a voluntary pilot project for mobile language learning for students who learn German as a…

  1. M-Kinyarwanda: Promoting Autonomous Language Learning through a Robust Mobile Application

    ERIC Educational Resources Information Center

    Bikorimana, Emmanuel; Rutayisire, Joachim; Omar, Mwana Said; Sun, Yi

    2017-01-01

    Kinyarwanda, the national official language used by the population of Rwanda, was greatly affected by the tragic history that faced the country. The 13th annual national dialogue held at Kigali from 21st to 22nd December 2015, recommended the government of Rwanda, to put in place all measures to enhance and maintain the above mentioned language.…

  2. International Students of Speech and Language Therapy in the UK: Choices about Where to Study and Whether to Return

    ERIC Educational Resources Information Center

    Goldbart, J.; Marshall, J.; Evans, I. R.

    2005-01-01

    The qualification leading to professional practice in speech and language therapy (SLT, also known as speech and language pathology) is not evenly available across the world. Geographic mobility and the availability of information are greater than at any other time in our history. Thus, initial SLT qualification courses in many countries are…

  3. "You Focus, I'm Talking": A CHAT Analysis of Mobile Dictionary Use in an Advanced EFL Class

    ERIC Educational Resources Information Center

    Lilley, Warren; Hardman, Joanne

    2017-01-01

    This article discusses how students and teachers in an Advanced English as a Foreign Language (EFL) class in Cape Town, South Africa, construct meaning through mobile phones. Drawing on Cultural-Historical Activity Theory (CHAT), mobile phones are viewed as cultural artefacts that learners and teachers engage in the construction of meaning-making…

  4. Development of Adaptive Kanji Learning System for Mobile Phone

    ERIC Educational Resources Information Center

    Li, Mengmeng; Ogata, Hiroaki; Hou, Bin; Hashimoto, Satoshi; Liu, Yuqin; Uosaki, Noriko; Yano, Yoneo

    2010-01-01

    This paper describes an adaptive learning system based on mobile phone email to support the study of Japanese Kanji. In this study, the main emphasis is on using the adaptive learning to resolve one common problem of the mobile-based email or SMS language learning systems. To achieve this goal, the authors main efforts focus on three aspects:…

  5. Post-Secondary Students Using the iPad to Learn English: An Impact Study

    ERIC Educational Resources Information Center

    Gitsaki, Christina; Robby, Matthew A.

    2014-01-01

    The use of mobile technology in language learning has increased considerably, with an unprecedented adoption of mobile tablets in K-12 and higher education settings. Despite the number of recent small-scale studies that have found increased student motivation and engagement in learning as a result of using mobile tablets, there is a need to…

  6. Mobile Learning and English Language Learners: A Case Study of Using iPod Touch as a Teaching and Learning Tool

    ERIC Educational Resources Information Center

    Liu, Min; Navarrete, Cesar; Maradiegue, Erin; Wivagg, Jennifer

    2014-01-01

    Educators have become increasingly interested in the learning benefits that mobile technology can provide to students in and out of classrooms. While there is considerable enthusiasm for using mobile devices to support learning with their multimedia capabilities, portability, connectivity, and flexibility, there is a paucity of research evidence…

  7. Using Mobile-Assisted Exercises to Support Students' Vocabulary Skill Development

    ERIC Educational Resources Information Center

    Suwantarathip, Ornprapat; Orawiwatnakul, Wiwat

    2015-01-01

    The use of mobile phones for learning has become well-known and is widely adopted in many language classes. The use of SMS for transmitting short messages is a fast way of helping students to learn vocabulary. To address this issue, this study was conducted to examine the effects of mobile-assisted vocabulary exercises on vocabulary acquisition of…

  8. Using Mobile Devices and the Adobe Connect Web Conferencing Tool in the Assessment of EFL Student Teacher Performance

    ERIC Educational Resources Information Center

    Bolona Lopez, Maria del Carmen; Ortiz, Margarita Elizabeth; Allen, Christopher

    2015-01-01

    This paper describes a project to use mobile devices and video conferencing technology in the assessment of student English as a Foreign Language (EFL) teacher performance on teaching practice in Ecuador. With the increasing availability of mobile devices with video recording facilities, it has become easier for trainers to capture teacher…

  9. Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization

    PubMed Central

    Witte, Kristen; Strickland, Devin; Glotzer, Michael

    2017-01-01

    Cell polarization underlies many cellular and organismal functions. The GTPase Cdc42 orchestrates polarization in many contexts. In budding yeast, polarization is associated with a focus of Cdc42•GTP which is thought to self sustain by recruiting a complex containing Cla4, a Cdc42-binding effector, Bem1, a scaffold, and Cdc24, a Cdc42 GEF. Using optogenetics, we probe yeast polarization and find that local recruitment of Cdc24 or Bem1 is sufficient to induce polarization by triggering self-sustaining Cdc42 activity. However, the response to these perturbations depends on the recruited molecule, the cell cycle stage, and existing polarization sites. Before cell cycle entry, recruitment of Cdc24, but not Bem1, induces a metastable pool of Cdc42 that is sustained by positive feedback. Upon Cdk1 activation, recruitment of either Cdc24 or Bem1 creates a stable site of polarization that induces budding and inhibits formation of competing sites. Local perturbations have therefore revealed unexpected features of polarity establishment. DOI: http://dx.doi.org/10.7554/eLife.26722.001 PMID:28682236

  10. Caffeine stabilizes Cdc25 independently of Rad3 in S chizosaccharomyces pombe contributing to checkpoint override

    PubMed Central

    Alao, John P; Sjölander, Johanna J; Baar, Juliane; Özbaki-Yagan, Nejla; Kakoschky, Bianca; Sunnerhagen, Per

    2014-01-01

    Cdc25 is required for Cdc2 dephosphorylation and is thus essential for cell cycle progression. Checkpoint activation requires dual inhibition of Cdc25 and Cdc2 in a Rad3-dependent manner. Caffeine is believed to override activation of the replication and DNA damage checkpoints by inhibiting Rad3-related proteins in both S chizosaccharomyces pombe and mammalian cells. In this study, we have investigated the impact of caffeine on Cdc25 stability, cell cycle progression and checkpoint override. Caffeine induced Cdc25 accumulation in S . pombe independently of Rad3. Caffeine delayed cell cycle progression under normal conditions but advanced mitosis in cells treated with replication inhibitors and DNA-damaging agents. In the absence of Cdc25, caffeine inhibited cell cycle progression even in the presence of hydroxyurea or phleomycin. Caffeine induces Cdc25 accumulation in S . pombe by suppressing its degradation independently of Rad3. The induction of Cdc25 accumulation was not associated with accelerated progression through mitosis, but rather with delayed progression through cytokinesis. Caffeine-induced Cdc25 accumulation appears to underlie its ability to override cell cycle checkpoints. The impact of Cdc25 accumulation on cell cycle progression is attenuated by Srk1 and Mad2. Together our findings suggest that caffeine overrides checkpoint enforcement by inducing the inappropriate nuclear localization of Cdc25. PMID:24666325

  11. Exchange programmes and student mobility: meeting student's expectations or an expensive holiday?

    PubMed

    Keogh, Johannes; Russel-Roberts, Eileen

    2009-01-01

    The Bologna Process aims, amongst other things, to improve the mobility of Students within the EU. Student mobility is supported through programmes such as ERASMUS, and the success of these programmes is measured against quality and quantity of Student mobility within the European Union. This study aimed at establishing, from the students' perspective, the benefits of these programmes. To this purpose, 7 Students who were involved in a German-Finnish exchange programme were interviewed. This population was chosen, because they represented the largest group of students going to the same host university, and were influenced by the same variables, such as language difficulties and climatic conditions. The main objective of this study was to determine whether the educational and personal needs of the students were met during their exchange programme. The data analysis was done using Mayring's content analysis method. The results showed that successful mobility at student level, could lead to a diffusion of knowledge and skills between different countries. It was also found that the students indicated that their personal and educational needs were met irrespective of the language difficulties they experienced.

  12. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

    PubMed

    Yan, Z; DeGregori, J; Shohet, R; Leone, G; Stillman, B; Nevins, J R; Williams, R S

    1998-03-31

    Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues of intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. Immunodepletion of Cdc6 by microinjection of anti-Cdc6 antibody blocks initiation of DNA replication in a human tumor cell line. We conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.

  13. Identification of cdc25 gene in pinewood nematode, Bursaphelenchus xylophilus, and its function in reproduction.

    PubMed

    Choi, Ye-Na; Oh, Bong-Kyeong; Kawasaki, Ichiro; Oh, Wan-Suk; Lee, Yi; Paik, Young-Ki; Shim, Yhong-Hee

    2010-02-28

    The cdc25 gene, which is highly conserved in many eukaryotes, encodes a phosphatase that plays essential roles in cell cycle regulation. We identified a cdc25 ortholog in the pinewood nematode, Bursaphelenchus xylophilus. The B. xylophilus ortholog (Bx-cdc25) was found to be highly similar to Caenorhabditis elegans cdc-25.2 in sequence as well as in gene structure, both having long intron 1. The Bx-cdc25 gene was determined to be composed of seven exons and six introns in a 2,580 bp region, and was shown to encode 360 amino acids of a protein containing a highly-conserved phosphatase domain. Bx-cdc25 mRNA was hardly detectable throughout the juvenile stages but was highly expressed in eggs and in both female and male adults. Functional conservation during germline development between C. elegans cdc25 and Bx-cdc25 was revealed by Bx-cdc25 RNA interference in C. elegans.

  14. Cosmopolitan Speakers and Their Cultural Cartographies

    ERIC Educational Resources Information Center

    Ros i Solé, Cristina

    2013-01-01

    Language learners' increased mobility and the ubiquity of virtual intercultural encounters has challenged traditional ideas of "cultures". Moreover, representations of cultures as consumable life-choices has meant that learners are no longer locked into standard and static cultural identities. Language learners are better defined as…

  15. A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae.

    PubMed Central

    Asakawa, K; Yoshida, S; Otake, F; Toh-e, A

    2001-01-01

    Exit from mitosis requires the inactivation of cyclin-dependent kinase (CDK) activity. In the budding yeast Saccharomyces cerevisiae, a number of gene products have been identified as components of the signal transduction network regulating inactivation of CDK (called the MEN, for the mitotic exit network). Cdc15, one of such components of the MEN, is an essential protein kinase. By the two-hybrid screening, we identified Cdc15 as a binding protein of Tem1 GTPase, another essential regulator of the MEN. Coprecipitation experiments revealed that Tem1 binds to Cdc15 in vivo. By deletion analysis, we found that the Tem1-binding domain resides near the conserved kinase domain of Cdc15. The cdc15-LF mutation, which was introduced into the Tem1-binding domain, reduced the interaction with Cdc15 and Tem1 and caused temperature-sensitive growth.The kinase activity of Cdc15 was not so much affected by the cdc15-LF mutation. However, Cdc15-LF failed to localize to the SPB at the restrictive temperature. Our data show that the interaction with Tem1 is important for the function of Cdc15 and that Cdc15 and Tem1 function in a complex to direct the exit from mitosis. PMID:11290702

  16. Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation.

    PubMed

    Wang, Jirong R; Wang, Chaojun J; Xu, Chengyun Y; Wu, Xiaokai K; Hong, Dun; Shi, Wei; Gong, Ying; Chen, Haixiao X; Long, Fanxin; Wu, Ximei M

    2016-03-01

    Endochondral ossification consists of successive steps of chondrocyte differentiation, including mesenchymal condensation, differentiation of chondrocytes, and hypertrophy followed by mineralization and ossification. Loss-of-function studies have revealed that abnormal growth plate cartilage of the Cdc42 mutant contributes to the defects in endochondral bone formation. Here, we have investigated the roles of Cdc42 in osteogenesis and signaling cascades governing Cdc42-mediated chondrogenic differentiation. Though deletion of Cdc42 in limb mesenchymal progenitors led to severe defects in endochondral ossification, either ablation of Cdc42 in limb preosteoblasts or knockdown of Cdc42 in vitro had no obvious effects on bone formation and osteoblast differentiation. However, in Cdc42 mutant limb buds, loss of Cdc42 in mesenchymal progenitors led to marked inactivation of p38 and Smad1/5, and in micromass cultures, Cdc42 lay on the upstream of p38 to activate Smad1/5 in bone morphogenetic protein-2-induced mesenchymal condensation. Finally, Cdc42 also lay on the upstream of protein kinase B to transactivate Sox9 and subsequently induced the expression of chondrocyte differential marker in transforming growth factor-β1-induced chondrogenesis. Taken together, by using biochemical and genetic approaches, we have demonstrated that Cdc42 is involved not in osteogenesis but in chondrogenesis in which the BMP2/Cdc42/Pak/p38/Smad signaling module promotes mesenchymal condensation and the TGF-β/Cdc42/Pak/Akt/Sox9 signaling module facilitates chondrogenic differentiation. Copyright © 2016 by the Genetics Society of America.

  17. PAN AIR: A computer program for predicting subsonic or supersonic linear potential flows about arbitrary configurations using a higher order panel method. Volume 4: Maintenance document (version 1.1)

    NASA Technical Reports Server (NTRS)

    Baruah, P. K.; Bussoletti, J. E.; Chiang, D. T.; Massena, W. A.; Nelson, F. D.; Furdon, D. J.; Tsurusaki, K.

    1981-01-01

    The Maintenance Document is a guide to the PAN AIR software system, a system which computes the subsonic or supersonic linear potential flow about a body of nearly arbitrary shape, using a higher order panel method. The document describes the over-all system and each program module of the system. Sufficient detail is given for program maintenance, updating and modification. It is assumed that the reader is familiar with programming and CDC (Control Data Corporation) computer systems. The PAN AIR system was written in FORTRAN 4 language except for a few COMPASS language subroutines which exist in the PAN AIR library. Structured programming techniques were used to provide code documentation and maintainability. The operating systems accommodated are NOS 1.2, NOS/BE and SCOPE 2.1.3 on the CDC 6600, 7600 and Cyber 175 computing systems. The system is comprised of a data management system, a program library, an execution control module and nine separate FORTRAN technical modules. Each module calculates part of the posed PAN AIR problem. The data base manager is used to communicate between modules and within modules. The technical modules must be run in a prescribed fashion for each PAN AIR problem. In order to ease the problem of supplying the many JCL cards required to execute the modules, a separate module called MEC (Module Execution Control) was created to automatically supply most of the JCL cards. In addition to the MEC generated JCL, there is an additional set of user supplied JCL cards to initiate the JCL sequence stored on the system.

  18. Thermal behavior of H-aggregate in a mixed Langmuir-Blodgett film of merocyanine dye, arachidic acid, and n-octadecane ternary system investigated by UV-visible and IR absorption spectroscopy.

    PubMed

    Hirano, Yoshiaki; Tateno, Shinsuke; Yamashita, Yoshihide; Ozaki, Yukihiro

    2008-11-13

    We have investigated the thermal behavior of H-aggregate in a mixed Langmuir-Blodgett (LB) film of the merocyanine dye (MS18)-arachidic acid (C20)- n-octadecane (AL18) ternary system by means of UV-visible and IR absorption spectroscopy in the range from 25 to 250 degrees C with a continuous scan. The results of both UV-visible and IR spectra indicate that the temperature-dependent variation in MS 18 aggregation state is linked not only with the degree of intramolecular charge transfer and the behavior of packing, orientation, conformation, and thermal mobility of the MS18 hydrocarbon chain but also with the presence and absence of AL18. The H-aggregate dissociates from 25 up to 50 degrees C, which is caused by the AL18 evaporation from the mixed LB film and the increment of thermal mobility of the MS18 hydrocarbon chain. From 110 to 160 degrees C, blue-shifted bands, attributed to the oligomeric MS18 aggregation, appear near 515 nm in the MS18-C 20-AL18 ternary system as well. The temperature at which the 515 nm band occurs is identical for both present ternary system and previously investigated MS18-deuterated arachidic acid (C20- d) binary system, and it is in good agreement with the melting point (110 degrees C) of cadmium arachidate (CdC20). Therefore, it is indicated that the driving force which induces the 515 nm band comes from the melting phenomenon of CdC20 molecules which are phase-separated from MS 18 molecules in as-deposited LB films.

  19. Optimizing Partner Notification Programs for Men Who Have Sex with Men: Factorial Survey Results from South China

    PubMed Central

    Tucker, Joseph D.; Chakraborty, Hrishikesh; Cohen, Myron S.; Chen, Xiang-Sheng

    2016-01-01

    Background Syphilis is prevalent among men who have sex with men (MSM) in China. Syphilis partner notification (PN) programs targeting MSM has been considered as one of effective strategies to prevention and control of the infection in the population. We examined willingness and preferences for PN among MSM to measure feasibility and optimize uptake. Methods Participation in a syphilis PN program was measured using a factorial survey from both the perspective of the index patient and the partner. Respondents were recruited from April-July 2011 using convenience sampling at two sites—a MSM sexually transmitted disease (STD) clinic and a MSM community based organization (CBO). Respondents first evaluated three factorial survey vignettes to measure probability of participation and then an anonymous sociodemographic questionnaire. A two-level mixed linear model was fitted for the factorial survey analysis. Results In 372 respondents with mean age (± SD) 28.5 (± 6.0) years, most were single (82.0%) and closeted gays (66.7%). The Internet was the most frequent place to search for sex. Few (31.2%) had legal names for casual partners, but most had instant messenger (86.5%) and mobile phone numbers (77.7%). The mean probability of participation in a syphilis PN program was 64.5% (± 32.4%) for index patients and 63.7% (± 32.6%) for partners. Referral of the partner to a private clinic or MSM CBO for follow-up decreased participation compared to the local Center for Disease Control and Prevention (CDC) or public STD clinic. Conclusions Enhanced PN services may be feasible among MSM in South China. Internet and mobile phone PN may contact partners untraceable by traditional PN. Referral of partners to the local CDC or public STD clinic may maximize PN participation. PMID:27462724

  20. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from the...

  1. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the SBA...

  2. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the SBA...

  3. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from the...

  4. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the SBA...

  5. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the SBA...

  6. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from the...

  7. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from the...

  8. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from the...

  9. Achieving recognition that mental health is part of the mission of CDC.

    PubMed

    Safran, Marc A

    2009-11-01

    For much of its history the U.S. Centers for Disease Control and Prevention (CDC) considered mental health to be outside of its mission. That assumption persisted even after CDC became a leading public health agency and began to face important mental health issues. This narrative describes how the organizational paradigm indicating that mental health was not mission related was challenged and superseded by a new paradigm recognizing mental health as part of CDC's public health mission. Even after the CDC Mental Health Work Group's establishment in 2000, CDC took eight more years to overcome powerful remnants of the old paradigm that had for so long excluded, minimized, or discouraged attention to mental health. The CDC Mental Health Work Group led the agency's mental health efforts without funding or dedicated staffing but with more than 100 CDC professionals from multiple disciplines and centers serving as voluntary members, in addition to their other CDC responsibilities.

  10. Comparative Field Evaluation of Different Traps for Collecting Adult Phlebotomine Sand Flies (Diptera: Psychodidae) in an Endemic Area of Cutaneous Leishmaniasis in Quintana Roo, Mexico.

    PubMed

    Rodríguez-Rojas, Jorge J; Arque-Chunga, Wilfredo; Fernández-Salas, Ildefonso; Rebollar-Téllez, Eduardo A

    2016-06-01

    Phlebotominae are the vectors of Leishmania parasites. It is important to have available surveillance and collection methods for the sand fly vectors. The objectives of the present study were to evaluate and compare traps for the collection of sand fly species and to analyze trap catches along months and transects. Field evaluations over a year were conducted in an endemic area of leishmaniasis in the state of Quintana Roo, Mexico. A randomized-block design was implemented in study area with tropical rainforest vegetation. The study design utilized 4 transects with 11 trap types: 1) Centers for Disease Control and Prevention (CDC) light trap with incandescent bulb (CDC-I), 2) CDC light trap with blue light-emitting diodes (LEDs) (CDC-B), 3) CDC light trap with white LEDs (CDC-W), 4) CDC light trap with red LEDs (CDC-R), 5) CDC light trap with green LEDs (CDC-G), 6) Disney trap, 7) Disney trap with white LEDs, 8) sticky panels, 9) sticky panels with white LEDs, 10) delta-like trap, and 11) delta-like trap with white LEDs. A total of 1,014 specimens of 13 species and 2 genera (Lutzomyia and Brumptomyia) were collected. There were significant differences in the mean number of sand flies caught with the 11 traps; CDC-I was (P  =  0.0000) more effective than the other traps. Other traps exhibited the following results: CDC-W (17.46%), CDC-B (15.68%), CDC-G (14.89%), and CDC-R (14.30%). The relative abundance of different species varied according to trap types used, and the CDC-I trap attracted more specimens of the known vectors of Leishmania spp., such as like Lutzomyia cruciata, Lu. shannoni, and Lu. ovallesi. Disney trap captured more specimens of Lu. olmeca olmeca. Based on abundance and number of species, CDC light traps and Disney traps appeared to be good candidates for use in vector surveillance programs in this endemic area of Mexico.

  11. Significance of Social Applications on a Mobile Phone for English Task-Based Language Learning

    ERIC Educational Resources Information Center

    Ahmad, Anmol; Farrukh, Fizza

    2015-01-01

    The utter importance of knowing the English language cannot be denied today. Despite the existence of traditional methods for teaching a language in schools, a big number of children are left without the requisite knowledge of English as a result of which they fail to compete in the modern world. With English being a Lingua Franca, more efforts…

  12. Language Needs Analysis from a Perspective of International Professional Mobility: The Case of French Mountain Guides

    ERIC Educational Resources Information Center

    Wozniak, Severine

    2010-01-01

    This paper gives a detailed account of an analysis carried out at the French National Skiing and Mountaineering School from August 2008 to June 2009 to assess the language needs of French mountain guides. A targeted literature review highlighted two main points to be taken into account in the design of this language needs analysis: target…

  13. Los estudiantes que se mudan de escuela y el logro academico (Student Mobility and Academic Achievement). ERIC Digest.

    ERIC Educational Resources Information Center

    Rumberger, Russell W.

    Student mobility (students moving from one school to another for reasons other than being promoted to the next school level) is widespread in the United States. This Spanish-language Digest examines the research on the academic consequences of mobility for elementary school students and discusses what schools and parents can do to mitigate the…

  14. University Administrators as Forced Language Policy Agents. An Institutional Ethnography of Parallel Language Strategy and Practices at the University of Copenhagen

    ERIC Educational Resources Information Center

    Siiner, Maarja

    2016-01-01

    Nation states increasingly assign the responsibility for meeting the global competitiveness agenda to the universities themselves [Cirius, 2009, "Mobilitetsstatistik for de videregaaende uddannelser 2007/08" [Mobility statistics for higher education 2007/08

  15. Developing Skills for Consultation with American Schools Overseas.

    ERIC Educational Resources Information Center

    Gerner, Michael E.

    This compilation of information addresses various issues facing internationally mobile children and adolescents. Some of the topics include: the different characteristics of Third-Culture Kids (TCKs); assessment practices and language and learning differences among TCKs, including an analysis of language problems, norm groups, and test…

  16. Managing Risk in Mobile Applications with Formal Security Policies

    DTIC Science & Technology

    2013-04-01

    Alternatively, Breaux and Powers (2009) found the Business Process Modeling Notation ( BPMN ), a declarative language for describing business processes, to be...the Business Process Execution Language (BPEL), preferred as the candidate formal semantics for BPMN , only works for limited classes of BPMN models

  17. Mobility in Higher Education: Cross-Cultural Communication Issues.

    ERIC Educational Resources Information Center

    Baumgratz, Gisela

    1993-01-01

    A study of the role of foreign languages in European higher education focused on the influence of institutional culture, including that of the discipline, on quality of professional communication. Findings are discussed, and related issues are examined, including student/professional mobility, interinstitutional cooperation, standards for…

  18. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway.

    PubMed

    Thomas, A; Giesler, T; White, E

    2000-11-02

    A member of the small G protein family, cdc42, was isolated from a screen undertaken to identify p53-inducible genes during apoptosis in primary baby rat kidney (BRK) cells transformed with E1A and a temperature-sensitive mutant p53 using a PCR-based subtractive hybridization method. Cdc42 is a GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases. In response to external stimuli, Cdc42 is known to transduce signals to regulate the organization of the actin cytoskeleton, induce DNA synthesis in quiescent fibroblasts, and promote apoptosis in neuronal and immune cells. In this study, we have demonstrated that cdc42 mRNA and protein were up-regulated in the presence of wild-type p53 in BRK cells, followed by cytoplasmic to plasma membrane translocation of Cdc42. Overexpression of Cdc42 in the presence of a dominant-negative mutant p53 induced apoptosis rapidly, indicating that Cdc42 functions downstream of p53. Furthermore, stable expression of a dominant-negative mutant of Cdc42 partially inhibited p53-mediated apoptosis. The Bcl-2 family members Bcl-xL, and the adenovirus protein E1B 19K, inhibited Cdc42-mediated apoptosis, whereas Bcl-2 did not. We provide evidence that PAK1 and JNK1 may play a role downstream of Cdc42 to transduce its apoptotic signal. Cdc42/PAK1 activates JNK1-induced phosphorylation of Bcl-2, thereby inactivating its function, and that a phosphorylation resistant mutant (Bcl-2S70,87A,T56,74A) gains the ability to inhibit Cdc42- and p53-mediated apoptosis. Thus, one mechanism by which p53 promotes apoptosis is through activation of Cdc42 and inactivation of Bcl-2.

  19. Assembly, molecular organization, and membrane-binding properties of development-specific septins

    PubMed Central

    Garcia, Galo; Finnigan, Gregory C.; Heasley, Lydia R.; Sterling, Sarah M.; Aggarwal, Adeeti; Pearson, Chad G.

    2016-01-01

    Septin complexes display remarkable plasticity in subunit composition, yet how a new subunit assembled into higher-order structures confers different functions is not fully understood. Here, this question is addressed in budding yeast, where during meiosis Spr3 and Spr28 replace the mitotic septin subunits Cdc12 and Cdc11 (and Shs1), respectively. In vitro, the sole stable complex that contains both meiosis-specific septins is a linear Spr28–Spr3–Cdc3–Cdc10–Cdc10–Cdc3–Spr3–Spr28 hetero-octamer. Only coexpressed Spr3 and Spr28 colocalize with Cdc3 and Cdc10 in mitotic cells, indicating that incorporation requires a Spr28-Spr3 protomer. Unlike their mitotic counterparts, Spr28-Spr3–capped rods are unable to form higher-order structures in solution but assemble to form long paired filaments on lipid monolayers containing phosphatidylinositol-4,5-bisphosphate, mimicking presence of this phosphoinositide in the prospore membrane. Spr28 and Spr3 fail to rescue the lethality of a cdc11Δ cdc12Δ mutant, and Cdc11 and Cdc12 fail to restore sporulation proficiency to spr3Δ/spr3Δ spr28Δ/spr28Δ diploids. Thus, specific meiotic and mitotic subunits endow septin complexes with functionally distinct properties. PMID:26929450

  20. PP2A(Cdc55)'s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.

    PubMed

    Kerr, Gary W; Wong, Jin Huei; Arumugam, Prakash

    2016-07-26

    PP2A(Cdc55) is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2A(Cdc55) activity undergo a premature exit from meiosis I which results in a failure to form bipolar spindles and divide nuclei. This defect is largely due to its role in negatively regulating the Cdc Fourteen Early Anaphase Release (FEAR) pathway. PP2A(Cdc55) prevents nucleolar release of the Cdk (Cyclin-dependent kinase)-antagonising phosphatase Cdc14 by counteracting phosphorylation of the nucleolar protein Net1 by Cdk. CDC55 was identified in a genetic screen for monopolins performed by isolating suppressors of spo11Δ spo12Δ lethality suggesting that Cdc55 might have a role in meiotic chromosome segregation. We investigated this possibility by isolating cdc55 alleles that suppress spo11Δ spo12Δ lethality and show that this suppression is independent of PP2A(Cdc55)'s FEAR function. Although the suppressor mutations in cdc55 affect reductional chromosome segregation in the absence of recombination, they have no effect on chromosome segregation during wild type meiosis. We suggest that Cdc55 is required for reductional chromosome segregation during achiasmate meiosis and this is independent of its FEAR function.

  1. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members, and...

  2. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC ethical requirements. 120.851... Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and their... § 120.140. In addition, they are subject to the following: (a) Any benefit flowing to a CDC's Associate...

  3. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members, and...

  4. 13 CFR 120.829 - Job Opportunity average a CDC must maintain.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Job Opportunity average a CDC must... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.829 Job Opportunity average a CDC must maintain. (a) A CDC's portfolio must maintain a minimum average of...

  5. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC ethical requirements. 120.851... Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and their... § 120.140. In addition, they are subject to the following: (a) Any benefit flowing to a CDC's Associate...

  6. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC ethical requirements. 120.851... Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and their... § 120.140. In addition, they are subject to the following: (a) Any benefit flowing to a CDC's Associate...

  7. 13 CFR 120.829 - Job Opportunity average a CDC must maintain.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Job Opportunity average a CDC must... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.829 Job Opportunity average a CDC must maintain. (a) A CDC's portfolio must maintain a minimum average of...

  8. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members, and...

  9. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that for...

  10. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except as...

  11. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members, and...

  12. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except as...

  13. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members, and...

  14. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that for...

  15. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that for...

  16. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that for...

  17. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except as...

  18. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that for...

  19. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except as...

  20. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except as...

  1. 13 CFR 120.829 - Job Opportunity average a CDC must maintain.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Job Opportunity average a CDC must... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.829 Job Opportunity average a CDC must maintain. (a) A CDC's portfolio must maintain a minimum average of...

  2. 75 FR 61505 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)-Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)--Health Disparities... provide recommendations for consideration to the ACD on strategic and other broad issues facing CDC... collaboration with the CDC Health Equity Workgroup; CDC Director's Annual Health Disparity Report; and briefing...

  3. cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis.

    PubMed

    Oh, Sangmi; Yoon, Sunghee; Youn, Esther; Kawasaki, Ichiro; Shim, Yhong-Hee

    2017-01-22

    Cell division cycle 25 (Cdc25) is an evolutionarily conserved phosphatase that promotes cell cycle progression by activating cyclin-dependent kinases (Cdks) which are inactivated by Wee1/Myt1 kinases. It was previously reported that cdc-25.2 promotes oocyte maturation and intestinal cell divisions in Caenorhabditis elegans hermaphrodites. Here, we report a novel function of cdc-25.2 in male tail development which was significantly deformed by cdc-25.2 RNAi depletion and in cdc-25.2 mutant males. The deformation was also observed after RNAi depletion of other cell cycle regulators, cdk-1, cyb-3, cyd-1, and cyl-1. Furthermore, wee-1.3 counteracted cdc-25.2 in male tail development as observed in oocyte maturation and intestine development. The number of cells in ray precursor cell lineages was significantly reduced in cdc-25.2 depleted males. These results indicate that CDC-25.2 is essential for cell divisions in ray precursor cell lineages for proper male tail development. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Cdc13 N-Terminal Dimerization DNA Binding and Telomere Length Regulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    M Mitchell; J Smith; M Mason

    The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that ismore » directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres.« less

  5. Underage Drinking

    MedlinePlus

    ... and Prevention (CDC). Fact Sheets: Underage Drinking . Atlanta, GA: CDC, 2016. Available at: http://www.cdc.gov/ ... Public Health: Alcohol-Related Disease Impact (ARDI) . Atlanta, GA: CDC, 2016. Available at: http://go.usa.gov/ ...

  6. Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp

    PubMed Central

    Xu, Ji-Dong; Jiang, Hai-Shan; Wei, Tian-Di; Zhang, Ke-Yi; Wang, Xian-Wei; Zhao, Xiao-Fan

    2016-01-01

    ABSTRACT Many types of small GTPases are widely expressed in eukaryotes and have different functions. As a crucial member of the Rho GTPase family, Cdc42 serves a number of functions, such as regulating cell growth, migration, and cell movement. Several RNA viruses employ Cdc42-hijacking tactics in their target cell entry processes. However, the function of Cdc42 in shrimp antiviral immunity is not clear. In this study, we identified a Cdc42 protein in the kuruma shrimp (Marsupenaeus japonicus) and named it MjCdc42. MjCdc42 was upregulated in shrimp challenged by white spot syndrome virus (WSSV). The knockdown of MjCdc42 and injection of Cdc42 inhibitors increased the proliferation of WSSV. Further experiments determined that MjCdc42 interacted with an arginine kinase (MjAK). By analyzing the binding activity and enzyme activity of MjAK and its mutant, ΔMjAK, we found that MjAK could enhance the replication of WSSV in shrimp. MjAK interacted with the envelope protein VP26 of WSSV. An inhibitor of AK activity, quercetin, could impair the function of MjAK in WSSV replication. Further study demonstrated that the binding of MjCdc42 and MjAK depends on Cys271 of MjAK and suppresses the WSSV replication-promoting effect of MjAK. By interacting with the active site of MjAK and suppressing its enzyme activity, MjCdc42 inhibits WSSV replication in shrimp. Our results demonstrate a new function of Cdc42 in the cellular defense against viral infection in addition to the regulation of actin and phagocytosis, which has been reported in previous studies. IMPORTANCE The interaction of Cdc42 with arginine kinase plays a crucial role in the host defense against WSSV infection. This study identifies a new mechanism of Cdc42 in innate immunity and enriches the knowledge of the antiviral innate immunity of invertebrates. PMID:28031362

  7. Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp.

    PubMed

    Xu, Ji-Dong; Jiang, Hai-Shan; Wei, Tian-Di; Zhang, Ke-Yi; Wang, Xian-Wei; Zhao, Xiao-Fan; Wang, Jin-Xing

    2017-03-01

    Many types of small GTPases are widely expressed in eukaryotes and have different functions. As a crucial member of the Rho GTPase family, Cdc42 serves a number of functions, such as regulating cell growth, migration, and cell movement. Several RNA viruses employ Cdc42-hijacking tactics in their target cell entry processes. However, the function of Cdc42 in shrimp antiviral immunity is not clear. In this study, we identified a Cdc42 protein in the kuruma shrimp ( Marsupenaeus japonicus ) and named it Mj Cdc42. Mj Cdc42 was upregulated in shrimp challenged by white spot syndrome virus (WSSV). The knockdown of Mj Cdc42 and injection of Cdc42 inhibitors increased the proliferation of WSSV. Further experiments determined that Mj Cdc42 interacted with an arginine kinase ( Mj AK). By analyzing the binding activity and enzyme activity of Mj AK and its mutant, Δ Mj AK, we found that Mj AK could enhance the replication of WSSV in shrimp. Mj AK interacted with the envelope protein VP26 of WSSV. An inhibitor of AK activity, quercetin, could impair the function of Mj AK in WSSV replication. Further study demonstrated that the binding of Mj Cdc42 and Mj AK depends on Cys 271 of Mj AK and suppresses the WSSV replication-promoting effect of Mj AK. By interacting with the active site of Mj AK and suppressing its enzyme activity, Mj Cdc42 inhibits WSSV replication in shrimp. Our results demonstrate a new function of Cdc42 in the cellular defense against viral infection in addition to the regulation of actin and phagocytosis, which has been reported in previous studies. IMPORTANCE The interaction of Cdc42 with arginine kinase plays a crucial role in the host defense against WSSV infection. This study identifies a new mechanism of Cdc42 in innate immunity and enriches the knowledge of the antiviral innate immunity of invertebrates. Copyright © 2017 American Society for Microbiology.

  8. Binding and inhibition of Cdc25 phosphatases by vitamin K analogues.

    PubMed

    Kar, Siddhartha; Lefterov, Iliya M; Wang, Meifang; Lazo, John S; Scott, Colleen N; Wilcox, Craig S; Carr, Brian I

    2003-09-09

    A synthetic K vitamin analogue, 2-(2-mercaptothenol)-3-methyl-1,4-naphthoquinone or Cpd 5, was previously found to be a potent inhibitor of cell growth [Nishikawa et al., (1995) J. Biol. Chem. 270, 28304-28310]. The mechanisms of cell growth were hypothesized to include the inactivation of cellular protein tyrosine phosphatases, especially the Cdc25 family [Tamura et al. (2000) Cancer Res. 60, 1317-1325]. In this study, we synthesized PD 49, a new biotin containing Cpd 5 derivative, to search for evidence of direct interaction of these arylating analogues with Cdc25A, Cdc25B, and Cdc25C phosphatases. PD 49 was shown to directly bind to GST-Cdc25A, GST-Cdc25B, their catalytic fragments, and GST-Cdc25C. The binding could be competed with excess glutathione or Cpd 5, and a cysteine-to-serine mutation of the catalytic cysteine abolished binding. This was consistent with an involvement in binding of cysteine in the catalytic domain. This interaction between PD 49 and Cdc25 also occurred in lysates of treated cells. PD 49 also bound to protein phosphatases other than Cdc25. We found that the new analogue also inhibited Hep3B human hepatoma cell growth. This growth inhibition involved ERK1/2 phosphorylation and was inhibited by a MEK antagonist. The results demonstrate a direct interaction and binding between this growth-inhibiting K vitamin derivative with both purified as well as with cellular Cdc25A, Cdc25B, and Cdc25C.

  9. Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells.

    PubMed

    Gao, Lei; Bai, Lan; Nan, Qing zhen

    2013-07-25

    The purpose of this study was to investigate the role of activated Rho GTPase cell division control protein 42 homolog (Cdc42) in colorectal cancer cell adhesion, migration, and invasion. The constitutively active form of Cdc42 (GFP-Cdc42L61) or control vector was overexpressed in the colorectal cancer cell line SW480. The localization of active Cdc42 was monitored by immunofluorescence staining, and the effects of active Cdc42 on cell migration and invasion were examined using an attachment assay, a wound healing assay, and a Matrigel migration assay in vitro. Immunofluorescence staining revealed that constitutively active Cdc42 predominately localized to the plasma membrane. Compared to SW480 cells transfected with the control vector, overexpression of constitutively active Cdc42 in SW480 cells promoted filopodia formation and cell stretch and dramatically enhanced cell adhesion to the coated plates. The wound healing assay revealed a significant increase of migration capability in SW480 cells expressing active Cdc42 compared to the control cells. Additionally, the Matrigel invasion assay demonstrated that active Cdc42 significantly promoted SW480 cell migration through the chamber. Our results suggest that active Rho GTPase Cdc42 can greatly enhance colorectal cancer cell SW480 to spread, migrate, and invade, which may contribute to colorectal cancer metastasis.

  10. Articles Published and Downloaded by Public Health Scientists: Analysis of Data From the CDC Public Health Library, 2011-2013.

    PubMed

    Iskander, John; Bang, Gail; Stupp, Emma; Connick, Kathy; Gomez, Onnalee; Gidudu, Jane

    2016-01-01

    To describe scientific information usage and publication patterns of the Centers for Disease Control and Prevention (CDC) Public Health Library and Information Center patrons. Administratively collected patron usage data and aggregate data on CDC-authored publications from the CDC Library for 3 consecutive years were analyzed. The CDC Public Health Library and Information Center, which serves CDC employees nationally and internationally. Internal patrons and external users of the CDC Library. Three-year trends in full-text article publication and downloads including most common journals used for each purpose, systematic literature searches requested and completed, and subscriptions to a weekly public health current literature awareness service. From 2011 to 2013, CDC scientists published a total of 7718 articles in the peer-reviewed literature. During the same period, article downloads from the CDC Library increased 25% to more than 1.1 million, completed requests for reviews of the scientific literature increased by 34%, and electronic subscriptions to literature compilation services increased by 23%. CDC's scientific output and information use via the CDC Library are both increasing. Researchers and field staff are making greater use of literature review services and other customized information content delivery. Virtual public health library access is an increasingly important resource for the scientific practice of public health.

  11. Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

    PubMed

    Tseng, Shun-Fu; Shen, Zih-Jie; Tsai, Hung-Ji; Lin, Yi-Hsuan; Teng, Shu-Chun

    2009-06-01

    Budding yeast telomerase is mainly activated by Tel1/Mec1 (yeast ATM/ATR) on Cdc13 from late S to G2 phase of the cell cycle. Here, we demonstrated that the telomerase-recruitment domain of Cdc13 is also phosphorylated by Cdk1 at the same cell cycle stage as the Tel1/Mec1-dependent regulation. Phosphor-specific gel analysis demonstrated that Cdk1 phosphorylates residues 308 and 336 of Cdc13. The residue T308 of Cdc13 is critical for efficient Mec1-mediated S306 phosphorylation in vitro. Phenotypic analysis in vivo revealed that the mutations in the Cdc13 S/TP motifs phosphorylated by Cdk1 caused cell cycle delay and telomere shortening and these phenotypes could be partially restored by the replacement with a negative charge residue. In the absence of Ku or Tel1, Cdk1-mediated phosphorylation of Cdc13 showed no effect on telomere length maintenance. Moreover, this Cdk1-mediated phosphorylation was required to promote the regular turnover of Cdc13. Together these results demonstrate that Cdk1 phosphorylates the telomerase recruitment domain of Cdc13, thereby preserves optimal function and expression level of Cdc13 for precise telomere replication and cell cycle progression.

  12. Language (In)competency, Communication Strategies, and the Development of an International Academic Teacher Identity: Becoming an Audible Minority

    ERIC Educational Resources Information Center

    McAllum, Kirstie

    2017-01-01

    Despite universities' enthusiasm for internationalization, international academic mobility requires considerable institutional and cultural adjustment in terms of teaching and supervision styles, research expectations, and departmental relationships. Although language competency underpins these practices, research on international academics has…

  13. Mobile Reading as Social and Embodied Practice

    ERIC Educational Resources Information Center

    Hellermann, John; Thorne, Steven L.; Fodor, Peter

    2017-01-01

    Literacy, and particularly reading, is critical to success in schooling and full participation in contemporary societies. As one of the primary skills needed to develop proficiency in a language, the study of reading in additional languages has attracted significant research attention. Focusing on behaviourally visible and locally occasioned…

  14. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small business...

  15. 33 CFR 165.503 - Security Zone; Captain of the Port Hampton Roads Zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... section— Certain dangerous cargo or CDC means a material defined as CDC in 33 CFR 160.204. Designated... a passenger vessel or vessel carrying a CDC, while the passenger vessel or vessel carrying CDC is... vessel or vessel carrying a CDC within the Captain of the Port Hampton Roads zone, unless traveling at...

  16. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the deposit...

  17. 33 CFR 165.503 - Security Zone; Captain of the Port Hampton Roads Zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... section— Certain dangerous cargo or CDC means a material defined as CDC in 33 CFR 160.204. Designated... a passenger vessel or vessel carrying a CDC, while the passenger vessel or vessel carrying CDC is... vessel or vessel carrying a CDC within the Captain of the Port Hampton Roads zone, unless traveling at...

  18. 42 CFR 73.7 - Registration and related security risk assessments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... requested in the registration application package (APHIS/CDC Form 1) to CDC. To apply for a certificate of... application package (APHIS/CDC Form 1) to CDC or APHIS, but not both. (e) Prior to the issuance of a... entity must immediately notify CDC or APHIS if it loses the services of its Responsible Official. In the...

  19. 75 FR 48699 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)--National Biosurveillance.... L. 92-463), the CDC announces the following meeting of aforementioned subcommittee: Time and Date: 8.... Purpose: As a subcommittee to the CDC's ACD, the NBAS will provide counsel to the CDC and the Federal...

  20. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small business...

  1. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small business...

  2. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one hundred-eighty...

  3. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small business...

  4. 42 CFR 73.7 - Registration and related security risk assessments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requested in the registration application package (APHIS/CDC Form 1) to CDC. To apply for a certificate of... application package (APHIS/CDC Form 1) to CDC or APHIS, but not both. (e) Prior to the issuance of a... entity must immediately notify CDC or APHIS if it loses the services of its Responsible Official. In the...

  5. 13 CFR 120.852 - Restrictions regarding CDC participation in the Small Business Investment Company (SBIC) program...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Restrictions regarding CDC... Company Loan Program (504) Other Cdc Requirements § 120.852 Restrictions regarding CDC participation in.... A CDC must not invest in or be an Affiliate of a Lender participating in the 7(a) loan program...

  6. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the deposit...

  7. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small business...

  8. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the deposit...

  9. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the deposit...

  10. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one hundred-eighty...

  11. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one hundred-eighty...

  12. 13 CFR 120.852 - Restrictions regarding CDC participation in the Small Business Investment Company (SBIC) program...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Restrictions regarding CDC... Company Loan Program (504) Other Cdc Requirements § 120.852 Restrictions regarding CDC participation in.... A CDC must not invest in or be an Affiliate of a Lender participating in the 7(a) loan program...

  13. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one hundred-eighty...

  14. 33 CFR 165.503 - Security Zone; Captain of the Port Hampton Roads Zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section— Certain dangerous cargo or CDC means a material defined as CDC in 33 CFR 160.204. Designated... a passenger vessel or vessel carrying a CDC, while the passenger vessel or vessel carrying CDC is... vessel or vessel carrying a CDC within the Captain of the Port Hampton Roads zone, unless traveling at...

  15. 13 CFR 120.852 - Restrictions regarding CDC participation in the Small Business Investment Company (SBIC) program...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Restrictions regarding CDC... Company Loan Program (504) Other Cdc Requirements § 120.852 Restrictions regarding CDC participation in.... A CDC must not invest in or be an Affiliate of a Lender participating in the 7(a) loan program...

  16. 13 CFR 120.852 - Restrictions regarding CDC participation in the Small Business Investment Company (SBIC) program...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Restrictions regarding CDC... Company Loan Program (504) Other Cdc Requirements § 120.852 Restrictions regarding CDC participation in.... A CDC must not invest in or be an Affiliate of a Lender participating in the 7(a) loan program...

  17. 13 CFR 120.852 - Restrictions regarding CDC participation in the Small Business Investment Company (SBIC) program...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Restrictions regarding CDC... Company Loan Program (504) Other Cdc Requirements § 120.852 Restrictions regarding CDC participation in.... A CDC must not invest in or be an Affiliate of a Lender participating in the 7(a) loan program...

  18. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the deposit...

  19. 42 CFR 73.7 - Registration and related security risk assessments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requested in the registration application package (APHIS/CDC Form 1) to CDC. To apply for a certificate of... application package (APHIS/CDC Form 1) to CDC or APHIS, but not both. (e) Prior to the issuance of a... entity must immediately notify CDC or APHIS if it loses the services of its Responsible Official. In the...

  20. Using PDA for Undergraduate Student Incidental Vocabulary Testing

    ERIC Educational Resources Information Center

    Song, Yanjie; Fox, Robert

    2008-01-01

    Recent studies have explored English vocabulary learning in environments where students used mobile technologies for prescribed vocabulary learning tasks, or tested designed personalized learning systems to enhance student vocabulary learning for short periods of time in language related courses. Dictionary use via mobile devices has mostly been…

  1. Tele-EnREDando.com: A Multimedia WEB-CALL Software for Mobile Phones.

    ERIC Educational Resources Information Center

    Garcia, Jose Carlos

    2002-01-01

    Presents one of the world's first prototypes of language learning software for smart-phones. Tele-EnREDando.com is an Internet based multimedia application designed for 3G mobile phones with audio, video, and interactive exercises for learning Spanish for business. (Author/VWL)

  2. Mobile robots IV; Proceedings of the Meeting, Philadelphia, PA, Nov. 6, 7, 1989

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wolfe, W.J.; Chun, W.H.

    1990-01-01

    The present conference on mobile robot systems discusses high-speed machine perception based on passive sensing, wide-angle optical ranging, three-dimensional path planning for flying/crawling robots, navigation of autonomous mobile intelligence in an unstructured natural environment, mechanical models for the locomotion of a four-articulated-track robot, a rule-based command language for a semiautonomous Mars rover, and a computer model of the structured light vision system for a Mars rover. Also discussed are optical flow and three-dimensional information for navigation, feature-based reasoning trail detection, a symbolic neural-net production system for obstacle avoidance and navigation, intelligent path planning for robot navigation in an unknown environment,more » behaviors from a hierarchical control system, stereoscopic TV systems, the REACT language for autonomous robots, and a man-amplifying exoskeleton.« less

  3. Norovirus

    MedlinePlus

    ... Safety Website CDC Vital Signs — Preventing Norovirus Outbreaks, Food Service has a Key Role CDC Vital Signs: Making ... Safety Website CDC Vital Signs — Preventing Norovirus Outbreaks, Food Service has a Key Role CDC Vital Signs: Making ...

  4. Tribology of carbide derived carbon films synthesized on tungsten carbide

    NASA Astrophysics Data System (ADS)

    Tlustochowicz, Marcin

    Tribologically advantageous films of carbide derived carbon (CDC) have been successfully synthesized on binderless tungsten carbide manufactured using the plasma pressure compaction (P2CRTM) technology. In order to produce the CDC films, tungsten carbide samples were reacted with chlorine containing gas mixtures at temperatures ranging from 800°C to 1000°C in a sealed tube furnace. Some of the treated samples were later dechlorinated by an 800°C hydrogenation treatment. Detailed mechanical and structural characterizations of the CDC films and sliding contact surfaces were done using a series of analytical techniques and their results were correlated with the friction and wear behavior of the CDC films in various tribosystems, including CDC-steel, CDC-WC, CDC-Si3N4 and CDC-CDC. Optimum synthesis and treatment conditions were determined for use in two specific environments: moderately humid air and dry nitrogen. It was found that CDC films first synthesized at 1000°C and then hydrogen post-treated at 800°C performed best in air with friction coefficient values as low as 0.11. However, for dry nitrogen applications, no dechlorination was necessary and both hydrogenated and as-synthesized CDC films exhibited friction coefficients of approximately 0.03. A model of tribological behavior of CDC has been proposed that takes into consideration the tribo-oxidation of counterface material, the capillary forces from adsorbed water vapor, the carbon-based tribofilm formation, and the lubrication effect of both chlorine and hydrogen.

  5. Biological and biochemical characterization of two new PLA2 isoforms Cdc-9 and Cdc-10 from Crotalus durissus cumanensis snake venom.

    PubMed

    Romero-Vargas, Frey Francisco; Ponce-Soto, Luis Alberto; Martins-de-Souza, Daniel; Marangoni, Sergio

    2010-01-01

    This work reports the purification, biological characterization and amino acid sequence of two new basic PLA(2) isoforms, Cdc-9 and Cdc-10, purified from the Crotalus durissus cumanensis venom by one step analytical chromatography reverse phase HPLC. The molecular masses of the PLA(2) were 14,175+/-2.7 Da for Cdc-9 and 14,228+/-3.5 Da for Cdc-10 both deduced by primary structure and confirmed by MALDI-TOF. The isoforms presented an amino acid sequence of 122 amino acid residues, being Cdc-9: SLVQFNKMIK FETRKSGLPF YAAYGCYCGW GGQRPKDATD RCCFVHDCCY GKVAKCNTKW DIYSYSLKSG YITCGKGTWC KEQICECDRV AAECLRRSLS TYKNEYMFYP DSRCREPPEY TC with pI value of 8.25 and Cdc-10: SLLQFNKMIK FETRKSGVPF YAAYGCYCGW GGRRPKDPTD RCCFVHDCCY GKLTKCNTKW DIYSYSLKSG YITCGKGTWC KEQICECDRV AAECLRRSLN TYKNEYMFYP DSRCRGPPEY TC with a pI value of 8.46, showing highly conserved Ca(2+)-binding and catalytic sites. The PLA(2) activity decreased when the isoforms Cdc-9 and Cdc-10 were incubated with 4-bromophenacyl bromide (p-BPB), anhydrous acetic acid and p-nitrobenzene sulfonyl fluoride (NBSF) when compared with the activity of both native isoforms. In mice, the PLA(2) isoforms Cdc-9 and Cdc-10 induced myonecrosis and edema. Myotoxic and edema activities were reduced after treatment of the isoforms with p-BPB; acetylation of the lysine residues and the treatment of PLA(2) with NBSF have also induced edema reduction. However, p-BPB strongly diminishes the local and systemic myotoxic effects.

  6. Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase [alpha

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Jia; Yang, Yuting; Wan, Ke

    Budding yeast Cdc13-Stn1-Ten1 (CST) complex plays an essential role in telomere protection and maintenance, and has been proposed to be a telomere-specific replication protein A (RPA)-like complex. Previous genetic and structural studies revealed a close resemblance between Stn1-Ten1 and RPA32-RPA14. However, the relationship between Cdc13 and RPA70, the largest subunit of RPA, has remained unclear. Here, we report the crystal structure of the N-terminal OB (oligonucleotide/oligosaccharide binding) fold of Cdc13. Although Cdc13 has an RPA70-like domain organization, the structures of Cdc13 OB folds are significantly different from their counterparts in RPA70, suggesting that they have distinct evolutionary origins. Furthermore, ourmore » structural and biochemical analyses revealed unexpected dimerization by the N-terminal OB fold and showed that homodimerization is probably a conserved feature of all Cdc13 proteins. We also uncovered the structural basis of the interaction between the Cdc13 N-terminal OB fold and the catalytic subunit of DNA polymerase {alpha} (Pol1), and demonstrated a role for Cdc13 dimerization in Pol1 binding. Analysis of the phenotypes of mutants defective in Cdc13 dimerization and Cdc13-Pol1 interaction revealed multiple mechanisms by which dimerization regulates telomere lengths in vivo. Collectively, our findings provide novel insights into the mechanisms and evolution of Cdc13.« less

  7. Implementation of the CDC translational informatics platform--from genetic variants to the national Swedish Rheumatology Quality Register.

    PubMed

    Abugessaisa, Imad; Gomez-Cabrero, David; Snir, Omri; Lindblad, Staffan; Klareskog, Lars; Malmström, Vivianne; Tegnér, Jesper

    2013-04-02

    Sequencing of the human genome and the subsequent analyses have produced immense volumes of data. The technological advances have opened new windows into genomics beyond the DNA sequence. In parallel, clinical practice generate large amounts of data. This represents an underused data source that has much greater potential in translational research than is currently realized. This research aims at implementing a translational medicine informatics platform to integrate clinical data (disease diagnosis, diseases activity and treatment) of Rheumatoid Arthritis (RA) patients from Karolinska University Hospital and their research database (biobanks, genotype variants and serology) at the Center for Molecular Medicine, Karolinska Institutet. Requirements engineering methods were utilized to identify user requirements. Unified Modeling Language and data modeling methods were used to model the universe of discourse and data sources. Oracle11g were used as the database management system, and the clinical development center (CDC) was used as the application interface. Patient data were anonymized, and we employed authorization and security methods to protect the system. We developed a user requirement matrix, which provided a framework for evaluating three translation informatics systems. The implementation of the CDC successfully integrated biological research database (15172 DNA, serum and synovial samples, 1436 cell samples and 65 SNPs per patient) and clinical database (5652 clinical visit) for the cohort of 379 patients presents three profiles. Basic functionalities provided by the translational medicine platform are research data management, development of bioinformatics workflow and analysis, sub-cohort selection, and re-use of clinical data in research settings. Finally, the system allowed researchers to extract subsets of attributes from cohorts according to specific biological, clinical, or statistical features. Research and clinical database integration is a real challenge and a road-block in translational research. Through this research we addressed the challenges and demonstrated the usefulness of CDC. We adhered to ethical regulations pertaining to patient data, and we determined that the existing software solutions cannot meet the translational research needs at hand. We used RA as a test case since we have ample data on active and longitudinal cohort.

  8. Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register

    PubMed Central

    2013-01-01

    Background Sequencing of the human genome and the subsequent analyses have produced immense volumes of data. The technological advances have opened new windows into genomics beyond the DNA sequence. In parallel, clinical practice generate large amounts of data. This represents an underused data source that has much greater potential in translational research than is currently realized. This research aims at implementing a translational medicine informatics platform to integrate clinical data (disease diagnosis, diseases activity and treatment) of Rheumatoid Arthritis (RA) patients from Karolinska University Hospital and their research database (biobanks, genotype variants and serology) at the Center for Molecular Medicine, Karolinska Institutet. Methods Requirements engineering methods were utilized to identify user requirements. Unified Modeling Language and data modeling methods were used to model the universe of discourse and data sources. Oracle11g were used as the database management system, and the clinical development center (CDC) was used as the application interface. Patient data were anonymized, and we employed authorization and security methods to protect the system. Results We developed a user requirement matrix, which provided a framework for evaluating three translation informatics systems. The implementation of the CDC successfully integrated biological research database (15172 DNA, serum and synovial samples, 1436 cell samples and 65 SNPs per patient) and clinical database (5652 clinical visit) for the cohort of 379 patients presents three profiles. Basic functionalities provided by the translational medicine platform are research data management, development of bioinformatics workflow and analysis, sub-cohort selection, and re-use of clinical data in research settings. Finally, the system allowed researchers to extract subsets of attributes from cohorts according to specific biological, clinical, or statistical features. Conclusions Research and clinical database integration is a real challenge and a road-block in translational research. Through this research we addressed the challenges and demonstrated the usefulness of CDC. We adhered to ethical regulations pertaining to patient data, and we determined that the existing software solutions cannot meet the translational research needs at hand. We used RA as a test case since we have ample data on active and longitudinal cohort. PMID:23548156

  9. A New Method of Viewing Attachment Document of eMail on Various Mobile Devices

    NASA Astrophysics Data System (ADS)

    Ko, Heeae; Seo, Changwoo; Lim, Yonghwan

    As the computing power of the mobile devices is improving rapidly, many kinds of web services are also available in mobile devices just as Email service. Mobile Mail Service began early, but this service is mostly limited in some specified mobile devices such as Smart Phone. That is a limitation that users have to purchase specified phone to be benefited from Mobile Mail Service. In this paper, it uses DIDL (digital item declaration language) markup type defined in MPEG-21 and MobileGate Server, and solved this problem. DIDL could be converted to other markup types which are displayed by mobile devices. By transforming PC Web Mail contents including attachment document to DIDL markup through MobileGate Server, the Mobile Mail Service could be available for all kinds of mobile devices.

  10. A computer program for calculating symmetrical aerodynamic characteristics and lateral-directional stability derivatives of wing-body combinations with blowing jets

    NASA Technical Reports Server (NTRS)

    Lan, C. E.; Mehrotra, S. C.; Fox, C. H., Jr.

    1978-01-01

    The necessary information for using a computer program to calculate the aerodynamic characteristics under symmetrical flight conditions and the lateral-directional stability derivatives of wing-body combinations with upper-surface-blowing (USB) or over-wing-blowing (OWB) jets are described. The following new features were added to the program: (1) a fuselage of arbitrary body of revolution has been included. The effect of wing-body interference can now be investigated, and (2) all nine lateral-directional stability derivatives can be calculated. The program is written in FORTRAN language and runs on CDC Cyber 175 and Honeywell 66/60 computers.

  11. NERVA dynamic analysis methodology, SPRVIB

    NASA Technical Reports Server (NTRS)

    Vronay, D. F.

    1972-01-01

    The general dynamic computer code called SPRVIB (Spring Vib) developed in support of the NERVA (nuclear engine for rocket vehicle application) program is described. Using normal mode techniques, the program computes kinematical responses of a structure caused by various combinations of harmonic and elliptic forcing functions or base excitations. Provision is made for a graphical type of force or base excitation input to the structure. A description of the required input format and a listing of the program are presented, along with several examples illustrating the use of the program. SPRVIB is written in FORTRAN 4 computer language for use on the CDC 6600 or the IBM 360/75 computers.

  12. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.

    PubMed

    Franz, André; Orth, Michael; Pirson, Paul A; Sonneville, Remi; Blow, J Julian; Gartner, Anton; Stemmann, Olaf; Hoppe, Thorsten

    2011-10-07

    Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. In the licensing step of DNA replication, CDT-1 is loaded onto chromatin to subsequently promote the recruitment of additional replication factors, including CDC-45 and GINS. During the elongation step, the CDC-45/GINS complex moves with the replication fork; however, it is largely unknown how its chromatin association is regulated. Here, we show that the chaperone-like ATPase CDC-48/p97 coordinates degradation of CDT-1 with release of the CDC-45/GINS complex. C. elegans embryos lacking CDC-48 or its cofactors UFD-1/NPL-4 accumulate CDT-1 on mitotic chromatin, indicating a critical role of CDC-48 in CDT-1 turnover. Strikingly, CDC-48(UFD-1/NPL-4)-deficient embryos show persistent chromatin association of CDC-45/GINS, which is a consequence of CDT-1 stabilization. Moreover, our data confirmed a similar regulation in Xenopus egg extracts, emphasizing a conserved coordination of licensing and elongation events during eukaryotic DNA replication by CDC-48/p97. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold.

    PubMed

    Chen, Hongkai; Shi, Nuo; Gao, Yongxiang; Li, Xu; Teng, Maikun; Niu, Liwen

    2012-08-01

    The yeast Paf1 complex (Paf1C), which is composed of the proteins Paf1, Cdc73, Ctr9, Leo1 and Rtf1, accompanies RNA polymerase II from the promoter to the 3'-end formation site of mRNA- and snoRNA-encoding genes. As one of the first identified subunits of Paf1C, yeast Cdc73 (yCdc73) takes part in many transcription-related processes, including binding to RNA polymerase II, recruitment and activation of histone-modification factors and communication with other transcriptional activators. The human homologue of yCdc73, parafibromin, has been identified as a tumour suppressor linked to breast, renal and gastric cancers. However, the functional mechanism of yCdc73 has until recently been unclear. Here, a 2.2 Å resolution crystal structure of the highly conserved C-terminal region of yCdc73 is reported. It revealed that yCdc73 appears to have a GTPase-like fold. However, no GTPase activity was observed. The crystal structure of yCdc73 will shed new light on the modes of function of Cdc73 and Paf1C.

  14. Item response theory analysis of Centers for Disease Control and Prevention Health-Related Quality of Life (CDC HRQOL) items in adults with arthritis.

    PubMed

    Mielenz, Thelma J; Callahan, Leigh F; Edwards, Michael C

    2016-03-12

    Examine the feasibility of performing an item response theory (IRT) analysis on two of the Centers for Disease Control and Prevention health-related quality of life (CDC HRQOL) modules - the 4-item Healthy Days Core Module (HDCM) and the 5-item Healthy days Symptoms Module (HDSM). Previous principal components analyses confirm that the two scales both assess a mix of mental (CDC-MH) and physical health (CDC-PH). The purpose is to conduct item response theory (IRT) analysis on the CDC-MH and CDC-PH scales separately. 2182 patients with self-reported or physician-diagnosed arthritis completed a cross-sectional survey including HDCM and HDSM items. Besides global health, the other 8 items ask the number of days that some statement was true; we chose to recode the data into 8 categories based on observed clustering. The IRT assumptions were assessed using confirmatory factor analysis and the data could be modeled using an unidimensional IRT model. The graded response model was used for IRT analyses and CDC-MH and CDC-PH scales were analyzed separately in flexMIRT. The IRT parameter estimates for the five-item CDC-PH all appeared reasonable. The three-item CDC-MH did not have reasonable parameter estimates. The CDC-PH scale is amenable to IRT analysis but the existing The CDC-MH scale is not. We suggest either using the 4-item Healthy Days Core Module (HDCM) and the 5-item Healthy days Symptoms Module (HDSM) as they currently stand or the CDC-PH scale alone if the primary goal is to measure physical health related HRQOL.

  15. Using Repellent Products to Protect against Mosquito-Borne Illnesses

    MedlinePlus

    ... Illnesses More Information CDC-Avoid Mosquito Bites CDC-Dengue CDC-Zika Virus CDC-Mosquito bite prevention for ... how to protect against the mosquitoes that transmit dengue, Zika, and other viral diseases ( Aedes albopictus and ...

  16. CDC Health Disparities and Inequalities Report--U.S. 2013

    MedlinePlus

    ... Health Literacy Health Equity CDC Health Disparities & Inequalities Report (CHDIR) Recommend on Facebook Tweet Share Compartir On ... More Information CDC Releases Second Health Disparities & Inequalities Report - United States, 2013 CDC and its partners work ...

  17. A Mobile Game-Based English Vocabulary Practice System Based on Portfolio Analysis

    ERIC Educational Resources Information Center

    Wu, Ting-Ting; Huang, Yueh-Min

    2017-01-01

    English learning has become a vital educational strategy in many non-English-speaking countries. Vocabulary is a critical element for language learners. Therefore, developing sufficient vocabulary knowledge enables effective communication. However, learning a foreign language is difficult and stressful. In addition, memorizing English vocabulary…

  18. Language as Ideology: The American Indian Case.

    ERIC Educational Resources Information Center

    Svensson, Frances

    1981-01-01

    Historical development of the politically, socially, economically, and racially scattered and factionalized Indian communities has led to a situation in which the development of symbolic ideology of broad appeal is necessary in the emergence of a substantive ideology. Language has an increasingly important role in the mobilization of American…

  19. Reconceptualizing the Nature of Goals and Outcomes in Language/s Education

    ERIC Educational Resources Information Center

    Leung, Constant; Scarino, Angela

    2016-01-01

    Transformations associated with the increasing speed, scale, and complexity of mobilities, together with the information technology revolution, have changed the demography of most countries of the world and brought about accompanying social, cultural, and economic shifts (Heugh, 2013). This complex diversity has changed the very nature of…

  20. Mobile-Assisted Language Learning and Language Learner Autonomy

    ERIC Educational Resources Information Center

    Lyddon, Paul

    2016-01-01

    In the modern age of exponential knowledge growth and accelerating technological development, the need to engage in lifelong learning is becoming increasingly urgent. Successful lifelong learning, in turn, requires learner autonomy, or "the capacity to take control of one's own learning" (Benson, 2011, p. 58), including all relevant…

  1. SEL/Project Language. Level II, Kindergarten, Volume II (Lessons 17-32).

    ERIC Educational Resources Information Center

    Valladares, Ann E.; And Others

    This curriculum guide contains the Southeastern Education Laboratory/Project Language Lessons 17-32 stressing listening, speaking, and reading readiness for disadvantaged kindergarten children. The lessons are designed to be used in the SEL's mobile preschool units or as readiness materials for kindergarten. The major emphasis of this intervention…

  2. Facilitating Language Tests Delivery through Tablet PCs

    ERIC Educational Resources Information Center

    Garcia Laborda, Jesus; Magal Royo, Teresa; Rodriguez Lazaro, Nieves; Marugan, L. Fuentes

    2015-01-01

    Modern trends in educational technology have evidenced the increasing importance of mobile devices in language learning. The need of sophisticated devices that can facilitate lifelong learning wherever the students might be. Facilitating learning, however, implies that students have to be assessed through the same delivery models that are used in…

  3. Linguistic Human Rights and Mobility

    ERIC Educational Resources Information Center

    Wee, Lionel

    2007-01-01

    The Linguistic Human Rights (LHRs) paradigm is motivated by the desire to combat linguistic discrimination, where speakers of discriminated languages find themselves unable to use their preferred language in society at large. However, in an increasingly globalised world where speakers may feel the need or the desire to travel across state…

  4. The Use of English as Ad Hoc Institutional Standard in the Belgian Asylum Interview

    ERIC Educational Resources Information Center

    Maryns, Katrijn

    2017-01-01

    In institutional settings of globalization, labelled languages are generally preferred over multilingual repertoires and mobile language resources. Drawing on linguistic-ethnographic analysis of the way English is treated as an invariable "ad hoc" idiom in the Belgian asylum interview, this article demonstrates how institutional measures…

  5. Acculturation and Communicative Mobility Among Former Soviet Nationalities.

    ERIC Educational Resources Information Center

    Haarmann, Harald; Holman, Eugene

    1997-01-01

    Discusses the strategies that the former Soviet states are evolving to balance the interests of dominant ethnic groups with those of linguistic minorities while constructing a national identity, highlighting language policy in action and focusing on acculturation processes and geographic mobility among groups. A case study of Estonia is also…

  6. Knowledge Mobilization and Educational Research: Politics, Languages and Responsibilities

    ERIC Educational Resources Information Center

    Fenwick, Tara, Ed.; Farrell, Lesley, Ed.

    2011-01-01

    How can educational research have more impact? What processes of knowledge exchange are most effective for increasing the uses of research results? How can research-produced knowledge be better "mobilized" among users such as practicing educators, policy makers, and the public communities? These sorts of questions are commanding urgent…

  7. A Blended Learning Scenario to Enhance Learners' Oral Production Skills

    ERIC Educational Resources Information Center

    Kim, Hee-Kyung

    2015-01-01

    This paper examines the effectiveness of a mobile assisted blended learning scenario for pronunciation in Korean language. In particular, we analyze how asynchronous oral communication between learners of Korean and native speakers via "kakaotalk" (an open source mobile phone application) may be beneficial to the learner in terms of…

  8. Using Mixed-Modality Vocabulary Learning on Mobile Devices: Design and Evaluation

    ERIC Educational Resources Information Center

    Ou-Yang, Fang Chuan; Wu, Wen-Chi Vivian

    2017-01-01

    To achieve better adaptive learning for mobile-assisted language learning (MALL), individual prior knowledge proficiency, perceptual learning style, and learning behavior should all be considered in system development. While reviewing the existing literature about MALL research, the researchers of this study found very few recent studies exploring…

  9. Mobile Adaptive Communication Support for Vocabulary Acquisition

    ERIC Educational Resources Information Center

    Epp, Carrie Demmans

    2014-01-01

    This work explores the use of an adaptive mobile tool for language learning. A school-based deployment study showed that the tool supported learning. A second study is being conducted in informal learning environments. Current work focuses on building models that increase our understanding of the relationship between application usage and learning.

  10. Migrating an Online Service to WAP - A Case Study.

    ERIC Educational Resources Information Center

    Klasen, Lars

    2002-01-01

    Discusses mobile access via wireless application protocol (WAP) to online services that is offered in Sweden through InfoTorg. Topics include the Swedish online market; filtering HTML data from an Internet/Web server into WML (wireless markup language); mobile phone technology; microbrowsers; WAP protocol; and future possibilities. (LRW)

  11. Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt/β-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury.

    PubMed

    Han, Bin; Zhao, Jun-Ying; Wang, Wu-Tao; Li, Zheng-Wei; He, Ai-Ping; Song, Xiao-Yang

    2017-05-01

    Schwann cells (SCs) are unique glial cells in the peripheral nerve and may secrete multiple neurotrophic factors, adhesion molecules, extracellular matrix molecules to form the microenvironment of peripheral nerve regeneration, guiding and supporting nerve proliferation and migration. Cdc42 plays an important regulatory role in dynamic changes of the cytoskeleton. However, there is a little study referred to regulation and mechanism of Cdc42 on glial cells after peripheral nerve injury. The present study investigated the role of Cdc42 in the proliferation and migration of SCs after sciatic nerve injury. Cdc42 expression was tested, showing that the mRNA and protein expression levels of Cdc42 were significantly up-regulated after sciatic nerve injury. Then, we isolated and purified SCs from injuried sciatic nerve at day 7. The purified SCs were transfected with Cdc42 siRNA and pcDNA3.1-Cdc42, and the cell proliferation, cell cycle and migration were assessed. The results implied that Cdc42 siRNA remarkably inhibited Schwann cell proliferation and migration, and resulted in S phase arrest. While pcDNA3.1-Cdc42 showed a contrary effect. Besides, we also observed that Cdc42 siRNA down-regulated the protein expression of β-catenin, Cyclin D1, c-myc and p-p38, which were up-regulated by pcDNA3.1-Cdc42. Meanwhile, the inhibitor of Wnt/β-catenin and p38 MAPK signaling pathway IWP-2 and SB203580 significantly inhibited the effect of pcDNA3.1-Cdc42 on cell proliferation and migration. Overall, our data indicate that Cdc42 regulates Schwann cell proliferation and migration through Wnt/β-catenin and p38 MAPK signaling pathway after sciatic nerve injury, which provides further insights into the therapy of the sciatic nerve injury.

  12. Characterization of the PcCdc42 small G protein from Pneumocystis carinii, which interacts with the PcSte20 life cycle regulatory kinase

    PubMed Central

    Krajicek, Bryan J.; Kottom, Theodore J.; Villegas, Leah

    2010-01-01

    Pneumocystis carinii (Pc) causes severe pneumonia in immunocompromised hosts. The binding of Pc trophic forms to alveolar epithelial cells is a central feature of infection, inducing the expression and activation of PcSte20, a gene participating in mating, proliferation, and pseudohyphal growth. In related fungi, Ste20 proteins are generally activated by immediate upstream small G proteins of the Cdc42-like family. PcCdc42 has not been previously described in Pneumocystis. To address the potential role of such a G protein in Pneumocystis, PcCdc42 was cloned from a Pc cDNA library. Using the full-length 576-bp PcCdc42 cDNA sequence, a CHEF blot of genomic DNA yielded a single band, providing evidence that this gene is present as a single copy within the genome. The total length of PcCdc42 cDNA was 576 bp with an estimated molecular mass of ∼38 kDa. BLASTP analysis demonstrated greater than 80% homology with other fungal Cdc42p proteins. Northern analysis indicated equal mRNA expression in both cystic and trophic life forms. Heterologous expression of PcCdc42 in Saccharomyces cerevisiae (Sc) demonstrated that PcCdc42p was able to restore growth in an ScCdc42Δ yeast strain. Additional assays with purified PcCdc42 protein demonstrated GTP binding and intrinsic GTPase activity, which was partially but significantly suppressed by Clostridium difficile toxin B, characteristic of Cdc42 GTPases. Furthermore, PcCdc42 protein was also shown to bind to the downstream PCSte20 kinase partner in the presence (but not the absence) of GTP. These data indicate that Pc possesses a Cdc42 gene expressing an active G protein, which binds the downstream regulatory kinase PcSte20, important in Pc life cycle regulation. PMID:19915161

  13. Cyclin B Proteolysis and the Cyclin-dependent Kinase Inhibitor rum1p Are Required for Pheromone-induced G1 Arrest in Fission Yeast

    PubMed Central

    Stern, Bodo; Nurse, Paul

    1998-01-01

    The blocking of G1 progression by fission yeast pheromones requires inhibition of the cyclin-dependent kinase cdc2p associated with the B-cyclins cdc13p and cig2p. We show that cyclosome-mediated degradation of cdc13p and cig2p is necessary for down-regulation of B-cyclin–associated cdc2p kinase activity and for phermone-induced G1 arrest. The cyclin-dependent kinase inhibitor rum1p is also required to maintain this G1 arrest; it binds both cdc13p and cig2p and is specifically required for cdc13p proteolysis. We propose that rum1p acts as an adaptor targeting cdc13p for degradation by the cyclosome. In contrast, the cig2p–cdc2p kinase can be down-regulated, and the cyclin cig2p can be proteolyzed independently of rum1p. We suggest that pheromone signaling inhibits the cig2p–cdc2p kinase, bringing about a transient G1 arrest. As a consequence, rum1p levels increase, thus inhibiting and inducing proteolysis of the cdc13p–cdc2p kinase; this is necessary to maintain G1 arrest. We have also shown that pheromone-induced transcription occurs only in G1 and is independent of rum1p. PMID:9614176

  14. Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Gwang Su; Kang, Jeeheon; Bang, Sung Woong

    2015-01-16

    Highlights: • Cdc6 protein is a component of the pre-replicative complex required for chromosomal replication initiation. • Cdc6 localized to centrosomes of S and G2 phases in a cell cycle-dependent manner. • The centrosomal localization was governed by centrosomal localization signal sequences of Cdc6. • Deletions or substitution mutations on the centrosomal localization signal interfered with centrosomal localization of the Cdc6 proteins. - Abstract: The Cdc6 protein has been primarily investigated as a component of the pre-replicative complex for the initiation of chromosome replication, which contributes to maintenance of chromosomal integrity. Here, we show that Cdc6 localized to the centrosomesmore » during S and G2 phases of the cell cycle. The centrosomal localization was mediated by Cdc6 amino acid residues 311–366, which are conserved within other Cdc6 homologues and contains a putative nuclear export signal. Deletions or substitutions of the amino acid residues did not allow the proteins to localize to centrosomes. In contrast, DsRed tag fused to the amino acid residues localized to centrosomes. These results indicated that a centrosome localization signal is contained within amino acid residues 311–366. The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.« less

  15. Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall.

    PubMed

    Kim, Il Hwan; Wang, Hong; Soderling, Scott H; Yasuda, Ryohei

    2014-07-08

    Cdc42 is a signaling protein important for reorganization of actin cytoskeleton and morphogenesis of cells. However, the functional role of Cdc42 in synaptic plasticity and in behaviors such as learning and memory are not well understood. Here we report that postnatal forebrain deletion of Cdc42 leads to deficits in synaptic plasticity and in remote memory recall using conditional knockout of Cdc42. We found that deletion of Cdc42 impaired LTP in the Schaffer collateral synapses and postsynaptic structural plasticity of dendritic spines in CA1 pyramidal neurons in the hippocampus. Additionally, loss of Cdc42 did not affect memory acquisition, but instead significantly impaired remote memory recall. Together these results indicate that the postnatal functions of Cdc42 may be crucial for the synaptic plasticity in hippocampal neurons, which contribute to the capacity for remote memory recall.

  16. Cdc20/p55 mediates the resistance to docetaxel in castration-resistant prostate cancer in a Bim-dependent manner.

    PubMed

    Wu, Fei; Lin, Yun; Cui, Peng; Li, Hongyun; Zhang, Lechao; Sun, Zeqiang; Huang, Shengliang; Li, Shun; Huang, Shiming; Zhao, Qingli; Liu, Qingyong

    2018-06-01

    At least to date, no effective treatment for advanced castration-resistant prostate cancer (CRPC) has been established. Recent studies indicated that cell division cycle 20 homolog (Cdc20) overexpression is associated with poor prognosis in patients with castration-resistant prostate cancer. However, the mechanism of Cdc20 in the development of docetaxel resistance in CRPC remains elusive. In this study, the transcription of Cdc20 was confirmed in three independent CRPC cell lines derived from different tissues, including LNCaP, PC3, and DU145. Docetaxel resistant (DR) cell lines were generated within the background of DU145 and PC3. The protein levels of Cdc20 and the biological phenotype were detected in both wild-type and DR cell lines. To further explore the mechanism of Cdc20 overexpression, stable cell lines with Cdc20 or Bcl-2 interacting mediator of cell death (Bim) deprivation were generated and examined for biological parameters. In addition, a specific Cdc20 inhibitor was used in DR cell lines to explore the potential solution for docetaxel resistant CRPC. Here, we identified Cdc20 is overexpressed in docetaxel resistant CRPC cell lines, including LNCaP, PC3, and DU145. We also reported that DR cell lines, which mimic the recurrent prostate cancer cells after docetaxel treatment, have higher levels of Cdc20 protein compared with the CRPC cell lines. Interestingly, the protein levels of Bim, an E3 ligase substrate of Cdc20, were decreased in DR cell lines compared with the wild-type, while the mRNA levels were similar. More importantly, in DR cell lines, the biological phenotype induced by Cdc20 deletion could be significantly reversed by the additional knockdown of Bim. As a result, docetaxel resistant prostate cancer cells treated with the pharmacological Cdc20 inhibitor became sensitive to docetaxel treatment. In conclusion, our data collectively demonstrated that Cdc20 overexpression facilitates the docetaxel resistant of the CRPC cell lines in a Bim-dependent manner. Furthermore, additionally targeting Cdc20 might be a promising solution for the treatment of the CRPC with docetaxel resistance.

  17. Rho GTPase protein Cdc42 is critical for postnatal cartilage development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nagahama, Ryo; Department of Orthodontics, School of Dentistry, Showa University, Tokyo; Yamada, Atsushi, E-mail: yamadaa@dent.showa-u.ac.jp

    2016-02-19

    Cdc42, a small Rho GTPase family member, has been shown to regulate multiple cellular functions in vitro, including actin cytoskeletal reorganization, cell migration, proliferation, and gene expression. However, its tissue-specific roles in vivo remain largely unknown, especially in postnatal cartilage development, as cartilage-specific Cdc42 inactivated mice die within a few days after birth. In this study, we investigated the physiological functions of Cdc42 during cartilage development after birth using tamoxifen-induced cartilage-specific inactivated Cdc42 conditional knockout (Cdc42 {sup fl/fl}; Col2-CreERT) mice, which were generated by crossing Cdc42 flox mice (Cdc42 {sup fl/fl}) with tamoxifen-induced type II collagen (Col2) Cre transgenic mice using a Cre/loxP system.more » The gross morphology of the Cdc42 cKO mice was shorter limbs and body, as well as reduced body weight as compared with the controls. In addition, severe defects were found in growth plate chondrocytes of the long bones, characterized by a shorter proliferating zone (PZ), wider hypertrophic zone (HZ), and loss of columnar organization of proliferating chondrocytes, resulting in delayed endochondral bone formation associated with abnormal bone growth. Our findings demonstrate the importance of Cdc42 for cartilage development during both embryonic and postnatal stages. - Highlights: • Tamoxifen-induced cartilage specific inactivated Cdc42 mutant mice were generated. • Cdc42 mutant mice were shorter limbs and body. • Severe defects were found in growth plate chondrocytes.« less

  18. UNIX-based data management system for the Mobile Satellite Propagation Experiment (PiFEx)

    NASA Technical Reports Server (NTRS)

    Kantak, Anil V.

    1987-01-01

    A new method is presented for handling data resulting from Mobile Satellite propagation experiments such as the Pilot Field Experiment (PiFEx) conducted by JPL. This method uses the UNIX operating system and C programming language. The data management system is implemented on a VAX minicomputer. The system automatically divides the large data file housing data from various experiments under a predetermined format into various individual files containing data from each experiment. The system also has a number of programs written in C and FORTRAN languages to allow the researcher to obtain meaningful quantities from the data at hand.

  19. Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

    PubMed Central

    Caligiuri, M; Connolly, T; Beach, D

    1997-01-01

    We have undertaken a biochemical analysis of the regulation of the G1/S-phase transition and commitment to the cell cycle in the fission yeast Schizosaccharomyces pombe. The execution of Start requires the activity of the Cdc2 protein kinase and the Sct1/Cdc10 transcription complex. Progression through G1 also requires the Ran1 protein kinase whose inactivation leads to activation of the meiotic pathway under conditions normally inhibitory to this process. We have found that in addition to Cdc2, Sct1/Cdc10 complex formation requires Ran1. We demonstrate that the Puc1 cyclin associates with Ran1 and Cdc10 in vivo and that the Ran1 protein kinase functions to control the association between Puc1 and Cdc10. In addition, we present evidence that the phosphorylation state of Cdc10 is altered upon inactivation of Ran1. These results provide biochemical evidence that demonstrate one mechanism by which the Ran1 protein kinase serves to control cell fate through Cdc10 and Puc1. Images PMID:9201720

  20. Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.

    PubMed

    Sherman, D A; Pasion, S G; Forsburg, S L

    1998-07-01

    The members of the MCM protein family are essential eukaryotic DNA replication factors that form a six-member protein complex. In this study, we use antibodies to four MCM proteins to investigate the structure of and requirements for the formation of fission yeast MCM complexes in vivo, with particular regard to Cdc19p (MCM2). Gel filtration analysis shows that the MCM protein complexes are unstable and can be broken down to subcomplexes. Using coimmunoprecipitation, we find that Mis5p (MCM6) and Cdc21p (MCM4) are tightly associated with one another in a core complex with which Cdc19p loosely associates. Assembly of Cdc19p with the core depends upon Cdc21p. Interestingly, there is no obvious change in Cdc19p-containing MCM complexes through the cell cycle. Using a panel of Cdc19p mutants, we find that multiple domains of Cdc19p are required for MCM binding. These studies indicate that MCM complexes in fission yeast have distinct substructures, which may be relevant for function.

  1. Multiple Domains of Fission Yeast Cdc19p (MCM2) Are Required for Its Association with the Core MCM Complex

    PubMed Central

    Sherman, Daniel A.; Pasion, Sally G.; Forsburg, Susan L.

    1998-01-01

    The members of the MCM protein family are essential eukaryotic DNA replication factors that form a six-member protein complex. In this study, we use antibodies to four MCM proteins to investigate the structure of and requirements for the formation of fission yeast MCM complexes in vivo, with particular regard to Cdc19p (MCM2). Gel filtration analysis shows that the MCM protein complexes are unstable and can be broken down to subcomplexes. Using coimmunoprecipitation, we find that Mis5p (MCM6) and Cdc21p (MCM4) are tightly associated with one another in a core complex with which Cdc19p loosely associates. Assembly of Cdc19p with the core depends upon Cdc21p. Interestingly, there is no obvious change in Cdc19p-containing MCM complexes through the cell cycle. Using a panel of Cdc19p mutants, we find that multiple domains of Cdc19p are required for MCM binding. These studies indicate that MCM complexes in fission yeast have distinct substructures, which may be relevant for function. PMID:9658174

  2. Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination

    PubMed Central

    Grandin, Nathalie; Damon, Christelle; Charbonneau, Michel

    2001-01-01

    Cdc13 performs an essential function in telomere end protection in budding yeast. Here, we analyze the consequences on telomere dynamics of cdc13-induced telomeric DNA damage in proliferating cells. Checkpoint-deficient cdc13-1 cells accumulated DNA damage and eventually senesced. However, these telomerase-proficient cells could survive by using homologous recombination but, contrary to telomerase-deficient cells, did so without prior telomere shortening. Strikingly, homologous recombination in cdc13-1 mec3, as well as in telomerase-deficient cdc13-1 cells, which were Rad52- and Rad50-dependent but Rad51-independent, exclusively amplified the TG1–3 repeats. This argues that not only short telomeres are substrates for type II recombination. The Cdc13-1 mutant protein harbored a defect in its association with Stn1 and Ten1 but also an additional, unknown, defect that could not be cured by expressing a Cdc13-1– Ten1–Stn1 fusion. We propose that Cdc13 prevents telomere uncapping and inhibits recombination between telomeric sequences through a pathway distinct from and complementary to that used by telomerase. PMID:11689452

  3. Learning the ABCs of pregnancy and newborn care through mobile technology

    PubMed Central

    Entsieh, Angela Afua; Emmelin, Maria; Pettersson, Karen Odberg

    2015-01-01

    Background The diffusion of mobile phones in low- and middle-income countries has taken place faster than any other infrastructural development. Mobile Midwife, a mobile application implemented in Ghana in 2010, sends timely messages in local languages to registered expectant mothers and new parents. The field of mobile health (mHealth) is severely underresearched, yet it can be an alternative for improving health systems and the ways in which health services are delivered. Objective Our goal was to investigate the role that Mobile Midwife technology has played in the lives of pregnant and nursing mothers in Awutu Senya District, Ghana. Design A total of three focus group discussions and 19 individual interviews were conducted. Discussions and interviews were recorded, transcribed verbatim from the local language to English, and analyzed by means of qualitative content analysis at the manifest and latent levels. Results The main findings show that while oscillating between modern and traditional practices, women gradually gained trust in Mobile Midwife's counselling and attempted to balance between myths and reality regarding nutrition in pregnancy. In addition, their decisions to seek essential obstetric care were enhanced by Mobile Midwife's advice. Women also felt strengthened in their understanding of the importance of seeking professional care during pregnancy and childbirth as well as recognizing signs of ill health in the newborn. Conclusions The findings indicate that Mobile Midwife could be an excellent tool in working towards the improvement of maternal health. Mobile Midwife will hopefully contribute to the stepwise achievement of the Sustainable Development Goals extended from the Millennium Development Goals, which expire at the end of 2015. There is a need for strong political will from key stakeholders, to embark in the field of mHealth as a complementary means to strengthen health systems. PMID:26673633

  4. Learning the ABCs of pregnancy and newborn care through mobile technology.

    PubMed

    Entsieh, Angela Afua; Emmelin, Maria; Pettersson, Karen Odberg

    2015-01-01

    The diffusion of mobile phones in low- and middle-income countries has taken place faster than any other infrastructural development. Mobile Midwife, a mobile application implemented in Ghana in 2010, sends timely messages in local languages to registered expectant mothers and new parents. The field of mobile health (mHealth) is severely underresearched, yet it can be an alternative for improving health systems and the ways in which health services are delivered. Our goal was to investigate the role that Mobile Midwife technology has played in the lives of pregnant and nursing mothers in Awutu Senya District, Ghana. A total of three focus group discussions and 19 individual interviews were conducted. Discussions and interviews were recorded, transcribed verbatim from the local language to English, and analyzed by means of qualitative content analysis at the manifest and latent levels. The main findings show that while oscillating between modern and traditional practices, women gradually gained trust in Mobile Midwife's counselling and attempted to balance between myths and reality regarding nutrition in pregnancy. In addition, their decisions to seek essential obstetric care were enhanced by Mobile Midwife's advice. Women also felt strengthened in their understanding of the importance of seeking professional care during pregnancy and childbirth as well as recognizing signs of ill health in the newborn. The findings indicate that Mobile Midwife could be an excellent tool in working towards the improvement of maternal health. Mobile Midwife will hopefully contribute to the stepwise achievement of the Sustainable Development Goals extended from the Millennium Development Goals, which expire at the end of 2015. There is a need for strong political will from key stakeholders, to embark in the field of mHealth as a complementary means to strengthen health systems.

  5. Role of cdc25 Phosphatases in Human Breast Cancer

    DTIC Science & Technology

    2008-05-01

    Cdc25C in these assays, their cat - alytically inactive mutants Cdc25B (C488S) and Cdc25C (C377S) (referred to as mt25B and mt25C) were generated and...chimeras. B and C, N25B and N25C (B) and their corresponding cat - alytically inactive mutants N25B/C and N25C/B (C). Cdc25B Inhibits Cell...HCT116 cells because similar results were obtained using U2OS (osteosarcoma) andHT1080 ( fibrosarcoma ) cells (data not shown). The level of Cdc25B

  6. Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth

    PubMed Central

    Zheng, Xin-De; Lee, Raymond Teck Ho; Wang, Yan-Ming; Lin, Qi-Shan; Wang, Yue

    2007-01-01

    Cyclin-dependent kinases (CDKs) control yeast morphogenesis, although how they regulate the polarity machinery remains unclear. The dimorphic fungus Candida albicans uses Cdc28/Hgc1, a CDK/cyclin complex, to promote persistent actin polarization for hyphal growth. Here, we report that Rga2, a GTPase-activating protein (GAP) of the central polarity regulator Cdc42, undergoes Hgc1-dependent hyperphosphorylation. Using the analog-sensitive Cdc28as mutant, we confirmed that Cdc28 controls Rga2 phosphorylation in vitro and in vivo. Deleting RGA2 produced elongated yeast cells without apparent effect on hyphal morphogenesis. However, deleting it or inactivating its GAP activity restored hyphal growth in hgc1Δ mutants, suggesting that Rga2 represses hyphal development and Cdc28/Hgc1 inactivates it upon hyphal induction. We provide evidence that Cdc28/Hgc1 may act to prevent Rga2 from localizing to hyphal tips, leading to localized Cdc42 activation for hyphal extension. Rga2 also undergoes transient Cdc28-dependent hyperphosphorylation at bud emergence, suggesting that regulating a GAP(s) of Cdc42 by CDKs may play an important role in governing different forms of polarized morphogenesis in yeast. This study reveals a direct molecular link between CDKs and the polarity machinery. PMID:17673907

  7. Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

    PubMed

    Kurasawa, Osamu; Oguro, Yuya; Miyazaki, Tohru; Homma, Misaki; Mori, Kouji; Iwai, Kenichi; Hara, Hideto; Skene, Robert; Hoffman, Isaac; Ohashi, Akihiro; Yoshida, Sei; Ishikawa, Tomoyasu; Cho, Nobuo

    2017-04-01

    Cell division cycle 7 (Cdc7) is a serine/threonine kinase that plays important roles in the regulation of DNA replication process. A genetic study indicates that Cdc7 inhibition can induce selective tumor-cell death in a p53-dependent manner, suggesting that Cdc7 is an attractive target for the treatment of cancers. In order to identify a new class of potent Cdc7 inhibitors, we generated a putative pharmacophore model based on in silico docking analysis of a known inhibitor with Cdc7 homology model. The pharmacophore model provided a minimum structural motif of Cdc7 inhibitor, by which preliminary medicinal chemistry efforts identified a dihydrothieno[3,2-d]-pyrimidin-4(1H)-one scaffold having a heteroaromatic hinge-binding moiety. The structure-activity relationship (SAR) studies resulted in the discovery of new, potent, and selective Cdc7 inhibitors 14a, c, e. Furthermore, the high selectivity of 14c, e for Cdc7 over Rho-associated protein kinase 1 (ROCK1) is discussed by utilizing a docking study with Cdc7 and ROCK2 crystal structures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. CDC Kerala 1: Organization of clinical child development services (1987-2013).

    PubMed

    Nair, M K C; George, Babu; Nair, G S Harikumaran; Bhaskaran, Deepa; Leena, M L; Russell, Paul Swamidhas Sudhakar

    2014-12-01

    The main objective of establishing the Child Development Centre (CDC), Kerala for piloting comprehensive child adolescent development program in India, has been to understand the conceptualization, design and scaling up of a pro-active positive child development initiative, easily replicable all over India. The process of establishing the Child Development Centre (CDC) Kerala for research, clinical services, training and community extension services over the last 25 y, has been as follows; Step 1: Conceptualization--The life cycle approach to child development; Step 2: Research basis--CDC model early stimulation is effective; Step 3: Development and validation of seven simple developmental screening tools; Step 4: CDC Diagnostic services--Ultrasonology and genetic, and metabolic laboratory; Step 5: Developing seven intervention packages; Step 6: Training--Post graduate diploma in clinical child development; Step 7: CDC Clinic Services--seven major ones; Step 8: CDC Community Services--Child development referral units; Step 9: Community service delivery models--Childhood disability and for adolescent care counselling projects; Step 10: National capacity building--Four child development related courses. CDC Kerala follow-up and clinic services are offered till 18 y of age and premarital counselling till 24 y of age as shown in "CDC Kerala Clinic Services Flow Chart" and 74,291 children have availed CDC clinic services in the last 10 y. CDC Kerala is the first model for comprehensive child adolescent development services using a lifecycle approach in the Government sector and hence declared as the collaborative centre for Rashtriya Bal Swasthya Karyakram (RBSK), in Kerala.

  9. Prevalence of Disability and Disability Type Among Adults--United States, 2013.

    PubMed

    Courtney-Long, Elizabeth A; Carroll, Dianna D; Zhang, Qing C; Stevens, Alissa C; Griffin-Blake, Shannon; Armour, Brian S; Campbell, Vincent A

    2015-07-31

    Understanding the prevalence of disability is important for public health programs to be able to address the needs of persons with disabilities. Beginning in 2013, to measure disability prevalence by functional type, the Behavioral Risk Factor Surveillance System (BRFSS), added five questions to identify disability in vision, cognition, mobility, self-care, and independent living. CDC analyzed data from the 2013 BRFSS to assess overall prevalence of any disability, as well as specific types of disability among noninstitutionalized U.S. adults. Across all states, disabilities in mobility and cognition were the most frequently reported types. State-level prevalence of each disability type ranged from 2.7% to 8.1% (vision); 6.9% to 16.8% (cognition); 8.5% to 20.7% (mobility); 1.9% to 6.2% (self-care) and 4.2% to 10.8% (independent living). A higher prevalence of any disability was generally seen among adults living in states in the South and among women (24.4%) compared with men (19.8%). Prevalences of any disability and disability in mobility were higher among older age groups. These are the first data on functional disability types available in a state-based health survey. This information can help public health programs identify the prevalence of and demographic characteristics associated with different disability types among U.S. adults and better target appropriate interventions to reduce health disparities.

  10. Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway

    PubMed Central

    Huang, Z; Zhang, L; Chen, Y; Zhang, H; Zhang, Q; Li, R; Ma, J; Li, Z; Yu, C; Lai, Y; Lin, T; Zhao, X; Zhang, B; Ye, Z; Liu, S; Wang, W; Liang, X; Liao, R; Shi, W

    2016-01-01

    Podocyte apoptosis is a major mechanism that leads to proteinuria in many chronic kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. The Rho family of small GTPases has been shown to be required in maintaining podocyte structure and function. Recent studies have indicated that podocyte-specific deletion of Cdc42 in vivo, but not of RhoA or Rac1, leads to congenital nephrotic syndrome and glomerulosclerosis. However, the underlying cellular events in podocyte controlled by Cdc42 remain unclear. Here, we assessed the cellular mechanisms by which Cdc42 regulates podocyte apoptosis. We found that the expression of Cdc42 and its activity were significantly decreased in high glucose-, lipopolysaccharide- or adriamycin-injured podocytes. Reduced Cdc42 expression in vitro and in vivo by small interfering RNA and selective Cdc42 inhibitor ML-141, respectively, caused podocyte apoptosis and proteinuria. Our results further demonstrated that insufficient Cdc42 or Nwasp, its downstream effector, could decrease the mRNA and protein expression of YAP, which had been regarded as an anti-apoptosis protein in podocyte. Moreover, our data indicated that the loss of stress fibers caused by Cdc42/Nwasp deficiency also decreased Yes-associated protein (YAP) mRNA and protein expression, and induced podocyte apoptosis. Podocyte apoptosis induced by Cdc42/Nwasp/stress fiber deficiency was significantly inhibited by overexpressing-active YAP. Thus, the Cdc42/Nwasp/stress fibers/YAP signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 would be one potent way to prevent proteinuria kidney diseases. PMID:26986510

  11. Characterization of Synthetic-Lethal Mutants Reveals a Role for the Saccharomyces Cerevisiae Guanine-Nucleotide Exchange Factor Cdc24p in Vacuole Function and Na(+) Tolerance

    PubMed Central

    White, W. H.; Johnson, D. I.

    1997-01-01

    Cdc24p is the guanine-nucleotide exchange factor for the Cdc42p GTPase, which controls cell polarity in Saccharomyces cerevisiae. To identify new genes that may affect cell polarity, we characterized six UV-induced csl (CDC24 synthetic-lethal) mutants that exhibited synthetic-lethality with cdc24-4(ts) at 23°. Five mutants were not complemented by plasmid-borne CDC42, RSR1, BUD5, BEM1, BEM2, BEM3 or CLA4 genes, which are known to play a role in cell polarity. The csl3 mutant displayed phenotypes similar to those observed with calcium-sensitive, Pet(-) vma mutants defective in vacuole function. CSL5 was allelic to VMA5, the vacuolar H(+)-ATPase subunit C, and one third of csl5 cdc24-4(ts) cells were elongated or had misshapen buds. A cdc24-4(ts) Δvma5::LEU2 double mutant did not exhibit synthetic lethality, suggesting that the csl5/vma5 cdc24-4(ts) synthetic-lethality was not simply due to altered vacuole function. The cdc24-4(ts) mutant, like Δvma5::LEU2 and csl3 mutants, was sensitive to high levels of Ca(2+) as well as Na(+) in the growth media, which did not appear to be a result of a fragile cell wall because the phenotypes were not remedied by 1 M sorbitol. Our results indicated that Cdc24p was required in one V-ATPase mutant and another mutant affecting vacuole morphology, and also implicated Cdc24p in Na(+) tolerance. PMID:9286667

  12. CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

    PubMed

    Imtiaz, Ayesha; Belyantseva, Inna A; Beirl, Alisha J; Fenollar-Ferrer, Cristina; Bashir, Rasheeda; Bukhari, Ihtisham; Bouzid, Amal; Shaukat, Uzma; Azaiez, Hela; Booth, Kevin T; Kahrizi, Kimia; Najmabadi, Hossein; Maqsood, Azra; Wilson, Elizabeth A; Fitzgerald, Tracy S; Tlili, Abdelaziz; Olszewski, Rafal; Lund, Merete; Chaudhry, Taimur; Rehman, Atteeq U; Starost, Matthew F; Waryah, Ali M; Hoa, Michael; Dong, Lijin; Morell, Robert J; Smith, Richard J H; Riazuddin, Sheikh; Masmoudi, Saber; Kindt, Katie S; Naz, Sadaf; Friedman, Thomas B

    2018-03-01

    The Cell Division-Cycle-14 gene encodes a dual-specificity phosphatase necessary in yeast for exit from mitosis. Numerous disparate roles of vertebrate Cell Division-Cycle-14 (CDC14A) have been proposed largely based on studies of cultured cancer cells in vitro. The in vivo functions of vertebrate CDC14A are largely unknown. We generated and analyzed mutations of zebrafish and mouse CDC14A, developed a computational structural model of human CDC14A protein and report four novel truncating and three missense alleles of CDC14A in human families segregating progressive, moderate-to-profound deafness. In five of these families segregating pathogenic variants of CDC14A, deaf males are infertile, while deaf females are fertile. Several recessive mutations of mouse Cdc14a, including a CRISPR/Cas9-edited phosphatase-dead p.C278S substitution, result in substantial perinatal lethality, but survivors recapitulate the human phenotype of deafness and male infertility. CDC14A protein localizes to inner ear hair cell kinocilia, basal bodies and sound-transducing stereocilia. Auditory hair cells of postnatal Cdc14a mutants develop normally, but subsequently degenerate causing deafness. Kinocilia of germ-line mutants of mouse and zebrafish have normal lengths, which does not recapitulate the published cdc14aa knockdown morphant phenotype of short kinocilia. In mutant male mice, degeneration of seminiferous tubules and spermiation defects result in low sperm count, and abnormal sperm motility and morphology. These findings for the first time define a new monogenic syndrome of deafness and male infertility revealing an absolute requirement in vivo of vertebrate CDC14A phosphatase activity for hearing and male fertility.

  13. Language Education Policy in Late Modernity: (Socio) Linguistic Ethnographies in the European Union

    ERIC Educational Resources Information Center

    Pérez-Milans, Miguel

    2015-01-01

    Focusing on developments in research on language education policy, this introduction to the thematic special issue begins with a sketch of the new problem space emerging at the intersection of intensified transnational mobility, expanding economic neo-liberalisation and institutionalised of multilingualism. It then identifies situated practice,…

  14. Designing for Ab Initio Blended Learning Environments: Identifying Systemic Contradictions

    ERIC Educational Resources Information Center

    Ó Doinn, Oisín

    2017-01-01

    In recent years, Computer Assisted Language Learning (CALL) has become more accessible than ever before. This is largely due to the proliferation of mobile computing devices and the growth of open online language-learning resources. Additionally, since the beginning of the millennium there has been massive growth in the number of students studying…

  15. 3D Talking-Head Mobile App: A Conceptual Framework for English Pronunciation Learning among Non-Native Speakers

    ERIC Educational Resources Information Center

    Ali, Ahmad Zamzuri Mohamad; Segaran, Kogilathah

    2013-01-01

    One of the critical issues pertaining learning English as second language successfully is pronunciation, which consequently contributes to learners' poor communicative power. This situation is moreover crucial among non-native speakers. Therefore, various initiatives have been taken in order to promote effective language learning, which includes…

  16. Pop Lyrics and Mobile Language Learning: Prospects and Challenges

    ERIC Educational Resources Information Center

    Werner, Valentin; Lehl, Maria; Walton, Jonathan

    2017-01-01

    Pop lyrics represent a rich, but underused resource in language teaching in both institutional and informal contexts. This is striking in view of analyses from the fields of motivational and cognitive psychology, didactics as well as linguistics, which all provide evidence for the inherent potential of pop lyrics. This paper will first take a…

  17. Language Policy from Below: Language Choice in Student Project Groups in a Multilingual University Setting

    ERIC Educational Resources Information Center

    Mortensen, Janus

    2014-01-01

    Internationalisation is a buzzword in European higher education, and many universities work hard to devise and implement strategies that will help facilitate increased transnational student mobility. In this context, English is commonly seen as the "natural" choice for university internationalisation, and English is accordingly promoted…

  18. Duolingo: A Mobile Application to Assist Second Language Learning

    ERIC Educational Resources Information Center

    Nushi, Musa; Eqbali, Mohamad Hosein

    2017-01-01

    Technology is changing the way languages are taught and learned. It has provided teachers with new facilities and approaches to teaching that can stimulate learners' interest while challenging their intellect (Blake, 2013, 2016; Stanley, 2013). As an example, new smartphone applications are being developed that make the task of learning ever more…

  19. Increasing Awareness and Talk Time through Free Messaging Apps

    ERIC Educational Resources Information Center

    Pollard, Andrew

    2015-01-01

    For many people, mobile phones are a part of modern life. Although the purpose of this technology revolves around language and communication, its application to language learning still appears to be underutilized. This is changing, as the widespread use of this handheld technology offers numerous opportunities to use functions that are ideal for…

  20. Going to the MALL: Mobile Assisted Language Learning

    ERIC Educational Resources Information Center

    Chinnery, George M.

    2006-01-01

    Practically since their availability, a succession of audiovisual recording devices (e.g., reel-to-reel, VCRs, PCs) has been used to capture language samples, and myriad playback and broadcast devices (e.g., phonographs, radios, televisions) have provided access to authentic speech samples. The espousal of audiolingual theory in the 1950s brought…

  1. Transnationalism and Literacy: Investigating the Mobility of People, Languages, Texts, and Practices in Contexts of Migration

    ERIC Educational Resources Information Center

    Lam, Wan Shun Eva; Warriner, Doris S.

    2012-01-01

    This review of research offers a synthesis and analysis of research studies that address issues of language and literacy practices and learning in transnational contexts of migration. We consider how theoretical concepts from transnational migration studies, including particular Boudieusian-inspired concepts such as transnational social field,…

  2. Web 2.0, Synthetic Immersive Environments, and Mobile Resources for Language Education

    ERIC Educational Resources Information Center

    Sykes, Julie M.; Oskoz, Ana; Thorne, Steven L.

    2008-01-01

    In light of the increasingly blurred line between mediated and nonmediated contexts for social, professional, and educational purposes, attention to the presence and use of innovative digital media is critical to the consideration of the future of computer-assisted language learning (CALL). This article reviews current trends in the use of…

  3. Games in Language Learning: Opportunities and Challenges

    ERIC Educational Resources Information Center

    Godwin-Jones, Robert

    2014-01-01

    There has been a substantial increase in recent years in the interest in using digital games for language learning. This coincides with the explosive growth in multiplayer online gaming and with the proliferation of mobile games for smart phones. It also reflects the growing recognition among educators of the importance of extramural, informal…

  4. The Tablet for Second Language Vocabulary Learning: Keyboard, Stylus or Multiple Choice

    ERIC Educational Resources Information Center

    Van Hove, Stephanie; Vanderhoven, Ellen; Cornillie, Frederik

    2017-01-01

    Mobile technologies are increasingly finding their way into classroom practice. While these technologies can create opportunities that may facilitate learning, including the learning of a second or foreign language (L2), the full potential of these new media often remains underexploited. A case in point concerns tablet applications for language…

  5. New Music Technologies: Platforms for Language Growth through Content

    ERIC Educational Resources Information Center

    Brooks, David L.

    2012-01-01

    This educational showcase highlights some of the musical applications and devices that run them for adding music-related content and instructional activities to the foreign language (FL) classroom. Actual instructional uses for these mobile information and communications technology (ICT) devices such as the iPod, iPad, and iPhone, and music apps…

  6. The Effect of Study Abroad on Intercultural Competence: Results from a Longitudinal Quasi-Experimental Study

    ERIC Educational Resources Information Center

    Heinzmann, Sybille; Künzle, Roland; Schallhart, Nicole; Müller, Marianne

    2015-01-01

    Skills in several foreign languages are among the core competencies demanded in today's multicultural, mobile and connected society. Foreign language teaching must promote the development of intercultural competence (IC) and adaptability. The present study was carried out in Switzerland among upper secondary school students, many of whom are…

  7. miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Yuefeng; Zhu, Xiaolan; Xu, Wenlin

    2013-02-15

    Highlights: ► miR-330 was inversely correlated with Cdc42 in colorectal cancer cells. ► Elevated miR-330 suppressed cell proliferation in vivo and in vitro. ► Elevated miR-330 mimicked the effect of Cdc42 knockdown. ► Restoration of Cdc42 could partially attenuate the effects of miR-330. -- Abstract: MicroRNAs are small non-coding RNA molecules that play important roles in the multistep process of colorectal carcinoma (CRC) development. However, the miRNA–mRNA regulatory network is far from being fully understood. The objective of this study was to investigate the expression and the biological roles of miR-330 in colorectal cancer cells. Cdc42, one of the bestmore » characterized members of the Rho GTPase family, was found to be up-regulated in several types of human tumors including CRC and has been implicated in cancer initiation and progression. In the present study, we identified miR-330, as a potential regulator of Cdc42, was found to be inversely correlated with Cdc42 expression in colorectal cancer cell lines. Ectopic expression of miR-330 down-regulated Cdc42 expression at both protein and mRNA level, mimicked the effect of Cdc42 knockdown in inhibiting proliferation, inducing G1 cell cycle arrest and apoptosis of the colorectal cancer cells, whereas restoration of Cdc42 could partially attenuate the effects of miR-330. In addition, elevated expression of miR-330 could suppress the immediate downstream effectors of Cdc42 and inhibit the growth of colorectal cancer cells in vivo. To sum up, our results establish a role of miR-330 in negatively regulating Cdc42 expression and colorectal cancer cell proliferation. They suggest that manipulating the expression level of Cdc42 by miR-330 has the potential to influence colorectal cancer progression.« less

  8. Embodying a cognitive model in a mobile robot

    NASA Astrophysics Data System (ADS)

    Benjamin, D. Paul; Lyons, Damian; Lonsdale, Deryle

    2006-10-01

    The ADAPT project is a collaboration of researchers in robotics, linguistics and artificial intelligence at three universities to create a cognitive architecture specifically designed to be embodied in a mobile robot. There are major respects in which existing cognitive architectures are inadequate for robot cognition. In particular, they lack support for true concurrency and for active perception. ADAPT addresses these deficiencies by modeling the world as a network of concurrent schemas, and modeling perception as problem solving. Schemas are represented using the RS (Robot Schemas) language, and are activated by spreading activation. RS provides a powerful language for distributed control of concurrent processes. Also, The formal semantics of RS provides the basis for the semantics of ADAPT's use of natural language. We have implemented the RS language in Soar, a mature cognitive architecture originally developed at CMU and used at a number of universities and companies. Soar's subgoaling and learning capabilities enable ADAPT to manage the complexity of its environment and to learn new schemas from experience. We describe the issues faced in developing an embodied cognitive architecture, and our implementation choices.

  9. Personalized Intelligent Mobile Learning System for Supporting Effective English Learning

    ERIC Educational Resources Information Center

    Chen, Chih-Ming; Hsu, Shih-Hsun

    2008-01-01

    Since English has been an international language, how to enhance English levels of people by useful computer assisted learning forms or tools is a critical issue in non-English speaking countries because it definitely affects the overall competition ability of a country. With the rapid growth of wireless and mobile technologies, the mobile…

  10. What Do Mobiles Speak in Algeria? Evidence from SMS Language

    ERIC Educational Resources Information Center

    Mostari, Hind Amel

    2009-01-01

    When Algeria opened its markets to foreign investment starting from the early 2000s, a technological boom occurred, including the expansion of mobile phone use. New technologies have had a considerable impact on the Algerian diglossic situation, in recent decades, and have contributed in the democratisation of the local dialects, which are being…

  11. Multimodal Interaction on English Testing Academic Assessment

    ERIC Educational Resources Information Center

    Magal-Royo, T.; Gimenez-Lopez, J. L.; Garcia Laborda, Jesus

    2012-01-01

    Multimodal interaction methods applied to learning environments of the English language will be a line for future research from the use of adapted mobile phones or PDAs. Today's mobile devices allow access and data entry in a synchronized manner through different channels. At the academic level we made the first analysis of English language…

  12. Internationalisation of Higher Education and Language Policy: Questions of Quality and Equity

    ERIC Educational Resources Information Center

    Hughes, Rebecca

    2007-01-01

    Three major drivers of internationalisation in higher education are student mobility, staff mobility and offshore delivery. All have increased rapidly over the last 20 years and a high-end estimate suggests that 6 million students will be studying abroad by 2020. Anglophone countries have dominated this process: four English-speaking countries…

  13. Researching Mobile-Assisted Chinese-Character Learning Strategies among Adult Distance Learners

    ERIC Educational Resources Information Center

    Qian, Kan; Owen, Nathaniel; Bax, Stephen

    2018-01-01

    In the field of teaching and learning Chinese as a foreign language (CFL), most studies investigate Chinese character learning strategies in pen-and-paper study by campus-based students. With the increase in distance-learning, and expanding popularity of smartphones and tablets and widespread availability of mobile applications for language…

  14. The Role of Mobile Technologies in Pre-Service Foreign Language Teacher Education

    ERIC Educational Resources Information Center

    Tolosa, Constanza

    2017-01-01

    Pre-service teacher education plays a pivotal role in ensuring that future teachers are prepared to integrate technology effectively to their teaching. One way of improving readiness in future teachers is integrating mobile technologies to discipline-specific teacher education courses. This article presents three case studies drawn from…

  15. State-Controlled Licensure and Interstate Mobility: Questions from Katrina

    ERIC Educational Resources Information Center

    Taylor, Carmen L.

    2006-01-01

    State licensure laws in speech-language pathology and audiology vary from state to state. Natural disaster displacements as well as trends in job mobility have increased the need for licensees to be able to have more fluidity in practicing from 1 state to another. Additionally, literature reviews on the history of professional licensure…

  16. The Relative Influence of Faculty Mobility on NJ HSPA Scores

    ERIC Educational Resources Information Center

    Graziano, Dana

    2013-01-01

    In this study, the researcher examined the strength and direction of relationships between New Jersey School Report Card Variables, in particular Faculty Mobility, and 2009-2010 New Jersey High School Proficiency Assessment (HSPA) Math and Language Arts Literacy test scores. Variables found to have an influence on standardized test scores in the…

  17. Migrants and Mobile Technology Use: Gaps in the Support Provided by Current Tools

    ERIC Educational Resources Information Center

    Epp, Carrie Demmans

    2017-01-01

    Our current understanding of how migrants use mobile tools to support their communication and language learning is inadequate. This study, therefore, explores the learner-initiated use of technologies to support their comprehension, production, and acquisition of English following migration to Canada. Information about migrant use of technologies…

  18. The Impact of Mobile Learning on Listening Anxiety and Listening Comprehension

    ERIC Educational Resources Information Center

    Rahimi, Mehrak; Soleymani, Elham

    2015-01-01

    This study aimed at investigating the impact of mobile learning on EFL learners' listening anxiety and listening comprehension. Fifty students of two intermediate English courses were selected and sampled as the experimental (n = 25) and control (n = 25) groups. Students' entry level of listening anxiety was assessed by foreign language listening…

  19. Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

    PubMed Central

    Kim, Il Hwan; Wang, Hong; Soderling, Scott H; Yasuda, Ryohei

    2014-01-01

    Cdc42 is a signaling protein important for reorganization of actin cytoskeleton and morphogenesis of cells. However, the functional role of Cdc42 in synaptic plasticity and in behaviors such as learning and memory are not well understood. Here we report that postnatal forebrain deletion of Cdc42 leads to deficits in synaptic plasticity and in remote memory recall using conditional knockout of Cdc42. We found that deletion of Cdc42 impaired LTP in the Schaffer collateral synapses and postsynaptic structural plasticity of dendritic spines in CA1 pyramidal neurons in the hippocampus. Additionally, loss of Cdc42 did not affect memory acquisition, but instead significantly impaired remote memory recall. Together these results indicate that the postnatal functions of Cdc42 may be crucial for the synaptic plasticity in hippocampal neurons, which contribute to the capacity for remote memory recall. DOI: http://dx.doi.org/10.7554/eLife.02839.001 PMID:25006034

  20. Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis

    PubMed Central

    Pelizon, Cristina; d’Adda di Fagagna, Fabrizio; Farrace, Lorena; Laskey, Ronald A.

    2002-01-01

    In eukaryotes, the initiation of DNA replication involves the ordered assembly on chromatin of pre-replicative complexes (pre-RCs), including the origin recognition complex (ORC), Cdc6, Cdt1 and the minichromosome maintenance proteins (MCMs). In light of its indispensable role in the formation of pre-RCs, Cdc6 binding to chromatin represents a key step in the regulation of DNA replication and cell proliferation. Here, we study the human Cdc6 (HuCdc6) protein during programmed cell death (apoptosis). We find that HuCdc6, but not HuOrc2 (a member of the ORC) or HuMcm5 (one of the MCMs), is specifically cleaved in several human cell lines induced to undergo apoptosis by a variety of stimuli. Expression of caspase-uncleavable mutant HuCdc6 attenuates apoptosis, delaying cell death. Therefore, an important function for cleavage of HuCdc6 is to prevent a wounded cell from replicating and to facilitate death. PMID:12151338

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