Steady state thermal radiometers
NASA Technical Reports Server (NTRS)
Loose, J. D. (Inventor)
1974-01-01
A radiometer is described operating in a vacuum under steady state conditions. The front element is an aluminum sheet painted on the outer side with black or other absorptive material of selected characteristics. A thermocouple is bonded to the inner side of the aluminum sheet. That is backed by highly insulative layers of glass fiber and crinkled, aluminized Mylar polyester. Those layers are backed with a sturdy, polyester sheet, and the entire lamination is laced together by nylon cords. The device is highly reliable in that it does not drift out of calibration, and is significantly inexpensive.
Einstein's steady-state cosmology
NASA Astrophysics Data System (ADS)
O'Raifeartaigh, Cormac
2014-09-01
Last year, a team of Irish scientists discovered an unpublished manuscript by Einstein in which he attempted to construct a "steady-state" model of the universe. Cormac O'Raifeartaigh describes the excitement of finding this previously unknown work.
NASA Astrophysics Data System (ADS)
Johns, G. D.; Drake, D. M.; Nelson, R. O.; Wilburn, W. S.; Archer, D. E.; Becker, J. A.; Bernstein, L. A.; Younes, W.; Garrett, P. E.; Yates, S. W.
1998-04-01
GEANIE (Germanium Array for Neutron-Induced Excitations) is a large-scale high-resolution Ge γ-ray spectrometer located at the Weapons Neutron Research (WNR) facility of the Los Alamos Neutron Science Center (LANSCE). Research with GEANIE includes forefront nuclear reaction and spectroscopy studies along with state-of-the-art measurements needed for the Stockpile Stewardship program. An overview of the spectrometer and ongoing research will be presented. Amparo Corporation, Santa Fe, NM
Inconsistencies in steady state thermodynamics
NASA Astrophysics Data System (ADS)
Dickman, Ronald; Motai, Ricardo
2014-03-01
We address the issue of extending thermodynamics to nonequilibrium steady states. Using driven stochastic lattice gases, we ask whether consistent definitions of an effective chemical potential μ, and an effective temperature Te, are possible. These quantities are determined via zero-flux conditions of particles and energy between the driven system and a reservoir. For the models considered here, the fluxes are given in terms of certain stationary average densities, eliminating the need to perturb the system by actually exchanging particles; μ and Te are thereby obtained via open-circuit measurements, using a virtual reservoir. In the lattice gas with nearest-neighbor exclusion, temperature is not relevant, and we find that the effective chemical potential, a function of density and drive strength, satisfies the zeroth law, and correctly predicts the densities of coexisting systems. In the Katz-Lebowitz-Spohn driven lattice gas, both μ and Te need to be defined. We show analytically that the zeroth law is violated, and determine the size of the violations numerically. Our results highlight a fundamental inconsistency in the extension of thermodynamics to nonequilibrium steady states. Research supported by CNPq, Brazil.
Multimode optical fibers: steady state mode exciter.
Ikeda, M; Sugimura, A; Ikegami, T
1976-09-01
The steady state mode power distribution of the multimode graded index fiber was measured. A simple and effective steady state mode exciter was fabricated by an etching technique. Its insertion loss was 0.5 dB for an injection laser. Deviation in transmission characteristics of multimode graded index fibers can be avoided by using the steady state mode exciter.
Irreversible processes at nonequilibrium steady states
Fox, Ronald Forrest
1979-01-01
It is shown that a Liapunov criterion exists for the stability of nonequilibrium steady states. This criterion is based upon the fluctuation-dissipation relation, as was first pointed out by Keizer. At steady states, the Liapunov function is constructed from the covariance matrix for the thermodynamic variables. Unlike the situation around equilibrium, at steady states the covariance matrix and the “excess entropy” matrix are not equivalent. The excess entropy, which serves as the Liapunov function around equilibrium, does not work in this capacity at steady states. Keizer's Liapunov function must be viewed as the first correct candidate for a proper Liapunov function for steady states. PMID:16592649
Solid state power amplifier as 805 MHz master source for the LANSCE coupled-cavity linac
Lyles, J.; Davis, J.
1998-12-31
From 100 to 800 MeV, the Los Alamos Neutron Science Center (LANSCE) proton linac receives RF power from forty-four 1.25 MW klystrons at 805 Megahertz (MHz). A single master RF source provides a continuous high level phase reference signal which drives the klystrons along the 731 meter-long linac through a coaxial transmission line. A single point failure of this system can deenergize the entire coupled-cavity linac (CCL) RF plant. The authors replaced a physically large air-cooled tetrode amplifier with a compact water-cooled unit based on modular amplifier pallets developed at LANSCE. Each 600 Watt pallet utilizes eight push-pull bipolar power transistor pairs operated in class AB. Four of these can easily provide the 2000 watt reference carrier from the stable master RF source. A radial splitter and combiner parallels the modules. This amplifier has proven to be completely reliable after two years of operation without failure. A second unit was constructed and installed for redundancy, and the old tetrode system was removed in 1998. The compact packaging for cooling, DC power, impedance matching, RF interconnection, and power combining met the electrical and mechanical requirements. CRT display of individual collector currents and RF levels is made possible with built-in samplers and a VXI data acquisition unit.
Morphodynamics: Rivers beyond steady state
NASA Astrophysics Data System (ADS)
Church, M.; Ferguson, R. I.
2015-04-01
The morphology of an alluvial river channel affects the movement of water and sediment along it, but in the longer run is shaped by those processes. This interplay has mostly been investigated empirically within the paradigm of Newtonian mechanics. In rivers, this has created an emphasis on equilibrium configurations with simple morphology and uniform steady flow. But transient adjustment, whether between equilibrium states or indefinitely, is to be expected in a world in which hydrology, sediment supply, and base level are not fixed. More fundamentally, water flows and all the phenomena that accompany them are inherently unsteady, and flows in natural channels are characteristically nonuniform. The morphodynamics of alluvial river channels is the striking consequence. In this paper, we develop the essential connection between the episodic nature of bed material transport and the production of river morphology, emphasizing the fundamental problems of sediment transport, the role of bar evolution in determining channel form, the role of riparian vegetation, and the wide range of time scales for change. As the key integrative exercise, we emphasize the importance of physics-based modeling of morphodynamics. We note consequences that can be of benefit to society if properly understood. These include the possibility to better be able to model how varying flows drive morphodynamic change, to understand the influence of the sediments themselves on morphodynamics, and to recognize the inherent necessity for rivers that transport bed material to deform laterally. We acknowledge pioneering contributions in WRR and elsewhere that have introduced some of these themes.
Non-Markovianity-assisted steady state entanglement.
Huelga, Susana F; Rivas, Ángel; Plenio, Martin B
2012-04-20
We analyze the steady state entanglement generated in a coherently coupled dimer system subject to dephasing noise as a function of the degree of Markovianity of the evolution. By keeping fixed the effective noise strength while varying the memory time of the environment, we demonstrate that non-Markovianity is an essential, quantifiable resource that may support the formation of steady state entanglement whereas purely Markovian dynamics governed by Lindblad master equations lead to separable steady states. This result illustrates possible mechanisms leading to long-lived entanglement in purely decohering, possibly local, environments. We present a feasible experimental demonstration of this noise assisted phenomenon using a system of trapped ions.
Amy Robinson; Audrey Archuleta; Barbara Maes; Dan Strottman; Earl Hoffman; Garth Tietjen; Gene Farnum; Geoff Greene; Joyce Roberts; Ken Johnson; Paul Lewis; Roger Pynn; Stan Schriber; Steve Sterbenz; Steve Wender; Sue Harper
1999-02-01
The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 and 1997, experiment reports from LANSCE users, as well as a search capability.
Practical steady-state enzyme kinetics.
Lorsch, Jon R
2014-01-01
Enzymes are key components of most biological processes. Characterization of enzymes is therefore frequently required during the study of biological systems. Steady-state kinetics provides a simple and rapid means of assessing the substrate specificity of an enzyme. When combined with site-directed mutagenesis (see Site-Directed Mutagenesis), it can be used to probe the roles of particular amino acids in the enzyme in substrate recognition and catalysis. Effects of interaction partners and posttranslational modifications can also be assessed using steady-state kinetics. This overview explains the general principles of steady-state enzyme kinetics experiments in a practical, rather than theoretical, way. Any biochemistry textbook will have a section on the theory of Michaelis-Menten kinetics, including derivations of the relevant equations. No specific enzymatic assay is described here, although a method for monitoring product formation or substrate consumption over time (an assay) is required to perform the experiments described.
Network inference in the nonequilibrium steady state
NASA Astrophysics Data System (ADS)
Dettmer, Simon L.; Nguyen, H. Chau; Berg, Johannes
2016-11-01
Nonequilibrium systems lack an explicit characterization of their steady state like the Boltzmann distribution for equilibrium systems. This has drastic consequences for the inference of the parameters of a model when its dynamics lacks detailed balance. Such nonequilibrium systems occur naturally in applications like neural networks and gene regulatory networks. Here, we focus on the paradigmatic asymmetric Ising model and show that we can learn its parameters from independent samples of the nonequilibrium steady state. We present both an exact inference algorithm and a computationally more efficient, approximate algorithm for weak interactions based on a systematic expansion around mean-field theory. Obtaining expressions for magnetizations and two- and three-point spin correlations, we establish that these observables are sufficient to infer the model parameters. Further, we discuss the symmetries characterizing the different orders of the expansion around the mean field and show how different types of dynamics can be distinguished on the basis of samples from the nonequilibrium steady state.
Steady state response of unsymmetrically laminated plates
Hosokawa, Kenji; Kawashima, Katsuya; Sakata, Toshiyuki
1995-11-01
A numerical approach for analyzing the forced vibration problem of a symmetrically laminated FRP (fiber reinforced plastic) composite plate was proposed by the authors. In the present paper, this approach is modified for application to an unsymmetrically laminated FRP composite plate. Numerical calculations are carried out for the clamped antisymmetrically laminated rectangular and elliptical plates which are a kind of unsymmetrically laminated plate. Then,, the effects of the lamina material and the fiber orientation angle on the steady state response are discussed. Furthermore, it is investigated that what structural damping factor is most influenced on the steady state response of an antisymmetrically laminated plate.
The Politics of the Steady State
ERIC Educational Resources Information Center
Taylor, Charles
1978-01-01
A steady state society has limits pertaining to population size, non-renewable resources, and production which emits heat or substances into soil, water, or the atmosphere. Respecting these limits means renouncing exponential quantitative growth and accepting a universally available consumption standard. (SW)
Steady-state inductive spheromak operation
Janos, A.C.; Jardin, S.C.; Yamada, M.
1985-02-20
The inductively formed spheromak configuration (S-1) can be maintained in a highly stable and controlled fashion. The method described eliminates the restriction to pulsed spheromak plasmas or the use of electrodes for steady-state operation, and, therefore, is a reactor-relevant formation and sustainment method.
Steady-state inductive spheromak operation
Janos, Alan C.; Jardin, Stephen C.; Yamada, Masaaki
1987-01-01
The inductively formed spheromak plasma can be maintained in a highly stable and controlled fashion. Steady-state operation is obtained by forming the plasma in the linked mode, then oscillating the poloidal and toroidal fields such that they have different phases. Preferably, the poloidal and magnetic fields are 90.degree. out of phase.
Steady-state spheromak reactor studies. Revision
Krakowski, R.A.; Hagenson, R.L.
1985-01-01
After summarizing the essential elements of a gun-sustained spheromak, the potential for a steady-state is explored by means of a comprehensive physics/engineering/costing model. A range of cost-optimized reactor design point is presented, and the sensitivity of cost to key physics, engineering, and operational variables is reported.
Steady state compact toroidal plasma production
Turner, William C.
1986-01-01
Apparatus and method for maintaining steady state compact toroidal plasmas. A compact toroidal plasma is formed by a magnetized coaxial plasma gun and held in close proximity to the gun electrodes by applied magnetic fields or magnetic fields produced by image currents in conducting walls. Voltage supply means maintains a constant potential across the electrodes producing an increasing magnetic helicity which drives the plasma away from a minimum energy state. The plasma globally relaxes to a new minimum energy state, conserving helicity according to Taylor's relaxation hypothesis, and injecting net helicity into the core of the compact toroidal plasma. Controlling the voltage so as to inject net helicity at a predetermined rate based on dissipative processes maintains or increases the compact toroidal plasma in a time averaged steady state mode.
On Typicality in Nonequilibrium Steady States
NASA Astrophysics Data System (ADS)
Evans, Denis J.; Williams, Stephen R.; Searles, Debra J.; Rondoni, Lamberto
2016-08-01
From the statistical mechanical viewpoint, relaxation of macroscopic systems and response theory rest on a notion of typicality, according to which the behavior of single macroscopic objects is given by appropriate ensembles: ensemble averages of observable quantities represent the measurements performed on single objects, because " almost all" objects share the same fate. In the case of non-dissipative dynamics and relaxation toward equilibrium states, " almost all" is referred to invariant probability distributions that are absolutely continuous with respect to the Lebesgue measure. In other words, the collection of initial micro-states (single systems) that do not follow the ensemble is supposed to constitute a set of vanishing, phase space volume. This approach is problematic in the case of dissipative dynamics and relaxation to nonequilibrium steady states, because the relevant invariant distributions attribute probability 1 to sets of zero volume, while evolution commonly begins in equilibrium states, i.e., in sets of full phase space volume. We consider the relaxation of classical, thermostatted particle systems to nonequilibrium steady states. We show that the dynamical condition known as Ω T-mixing is necessary and sufficient for relaxation of ensemble averages to steady state values. Moreover, we find that the condition known as weak T-mixing applied to smooth observables is sufficient for ensemble relaxation to be independent of the initial ensemble. Lastly, we show that weak T-mixing provides a notion of typicality for dissipative dynamics that is based on the (non-invariant) Lebesgue measure, and that we call physical ergodicity.
Variational methods in steady state diffusion problems
Lee, C.E.; Fan, W.C.P.; Bratton, R.L.
1983-01-01
Classical variational techniques are used to obtain accurate solutions to the multigroup multiregion one dimensional steady state neutron diffusion equation. Analytic solutions are constructed for benchmark verification. Functionals with cubic trial functions and conservational lagrangian constraints are exhibited and compared with nonconservational functionals with respect to neutron balance and to relative flux and current at interfaces. Excellent agreement of the conservational functionals using cubic trial functions is obtained in comparison with analytic solutions.
Theory of Steady-State Superradiance
NASA Astrophysics Data System (ADS)
Xu, Minghui
In this thesis, I describe the theoretical development of the superradiant laser, or laser in the extreme bad-cavity regime. In this regime, the cavity decay rate is much greater than the atomic dynamics. The atoms emit photons into the cavity mode superradiantly in steady state. We develop group-theoretic methods that enable us to exactly solve mesoscopic systems with hundreds of atoms. We demonstrate the synchronization of atomic dipoles in steady-state superradiance. With this synchronized system, we propose conditional Ramsey spectroscopy which allows us to observe Ramsey fringes indefinitely, even in the presence of atomic decoherence. Furthermore, we explore manifestations of synchronization in the quantum realm with two superradiant atomic ensembles. We show that two such ensembles exhibit a dynamical phase transition from two disparate oscillators to quantum phase-locked dynamics. Finally, we study the mechanical eect of the light-atom interaction in the steady-state superradiance. We find efficient many-body cooling of atoms. The work described in this thesis lays the theoretical foundation for the superradiant laser and for a potential future of active optical frequency standards.
Intensity fluctuations in steady-state superradiance
Meiser, D.; Holland, M. J.
2010-06-15
Alkaline-earth-metal-like atoms with ultranarrow optical transitions enable superradiance in steady state. The emitted light promises to have an unprecedented stability with a linewidth as narrow as a few millihertz. In order to evaluate the potential usefulness of this light source as an ultrastable oscillator in clock and precision metrology applications, it is crucial to understand the noise properties of this device. In this paper, we present a detailed analysis of the intensity fluctuations by means of Monte Carlo simulations and semiclassical approximations. We find that the light exhibits bunching below threshold, is to a good approximation coherent in the superradiant regime, and is chaotic above the second threshold.
Steady state stresses in ribbon parachute canopies
NASA Technical Reports Server (NTRS)
Garrard, W. L.; Wu, K. Y.; Muramoto, K. K.
1984-01-01
An experimental study of the steady state stresses in model ribbon parachute canopies is presented. The distribution of circumferential stress was measured in the horizontal ribbons of two parachutes using Omega sensors. Canopy pressure distributions and overall drag were also measured. Testing was conducted in the University of Minnesota Low-Speed Wind Tunnel at dynamic pressures ranging from 1.0 to 1.5 inches of water. The stresses in the parachute canopies were calculated using the parachute structural analysis code, CANO. It was found that the general shape of the measured and calculated stress distributions was fairly similar; however, the measured stresses were somewhat less than the calculated stresses.
Gravitational steady states of solar coronal loops
NASA Astrophysics Data System (ADS)
Sugiyama, Linda E.; Asgari-Targhi, M.
2017-02-01
Coronal loops on the surface of the sun appear to consist of curved, plasma-confining magnetic flux tubes or "ropes," anchored at both ends in the photosphere. Toroidal loops carrying current are inherently unstable to expansion in the major radius due to toroidal-curvature-induced imbalances in the magnetic and plasma pressures. An ideal MHD analysis of a simple isolated loop with density and pressure higher than the surrounding corona, based on the theory of magnetically confined toroidal plasmas, shows that the radial force balance depends on the loop internal structure and varies over parameter space. It provides a unified picture of simple loop steady states in terms of the plasma beta βo, the inverse aspect ratio ɛ =a /Ro , and the MHD gravitational parameter G ̂≡g a /vA2 , all at the top of the loop, where g is the acceleration due to gravity, a the average minor radius, and vA the shear Alfvén velocity. In the high and low beta tokamak orderings, βo=2 noT /(Bo2/2 μo)˜ɛ1 and ɛ2 , that fit many loops, the solar gravity can sustain nonaxisymmetric steady states at G ̂˜ɛ βo that represent the maximum stable height. At smaller G ̂≤ɛ2βo , the loop is axisymmetric to leading order and stabilized primarily by the two fixed loop ends. Very low beta, nearly force-free, steady states with βo˜ɛ3 may also exist, with or without gravity, depending on higher order effects. The thin coronal loops commonly observed in solar active regions have ɛ ≃0.02 and fit the high beta steady states. G ̂ increases with loop height. Fatter loops in active regions that form along magnetic neutral lines and may lead to solar flares and Coronal Mass Ejections have ɛ ≃0.1 -0.2 and may fit the low beta ordering. Larger loops tend to have G ̂>ɛ βo and be unstable to radial expansion because the exponential hydrostatic reduction in the density at the loop-top reduces the gravitational force -ρG ̂ R ̂ below the level that balances expansion, in agreement with
Intense steady state electron beam generator
Hershcovitch, Ady; Kovarik, Vincent J.; Prelec, Krsto
1990-01-01
An intense, steady state, low emittance electron beam generator is formed by operating a hollow cathode discharge plasma source at critical levels in combination with an extraction electrode and a target electrode that are operable to extract a beam of fast primary electrons from the plasma source through a negatively biased grid that is critically operated to repel bulk electrons toward the plasma source while allowing the fast primary electrons to move toward the target in the desired beam that can be successfully transported for relatively large distances, such as one or more meters away from the plasma source.
Energy repartition in the nonequilibrium steady state
NASA Astrophysics Data System (ADS)
Yan, Peng; Bauer, Gerrit E. W.; Zhang, Huaiwu
2017-01-01
The concept of temperature in nonequilibrium thermodynamics is an outstanding theoretical issue. We propose an energy repartition principle that leads to a spectral (mode-dependent) temperature in steady-state nonequilibrium systems. The general concepts are illustrated by analytic solutions of the classical Heisenberg spin chain connected to Langevin heat reservoirs with arbitrary temperature profiles. Gradients of external magnetic fields are shown to localize spin waves in a Wannier-Zeemann fashion, while magnon interactions renormalize the spectral temperature. Our generic results are applicable to other thermodynamic systems such as Newtonian liquids, elastic solids, and Josephson junctions.
An Intuitive Approach to Steady-State Kinetics.
ERIC Educational Resources Information Center
Raines, Ronald T.; Hansen, David E.
1988-01-01
Attempts to provide an intuitive understanding of steady state kinetics. Discusses the meaning of steady state and uses free energy profiles to illustrate and follow complex kinetic and thermodynamic relationships. Provides examples with explanations. (MVL)
Statistical steady state in turbulent droplet condensation
NASA Astrophysics Data System (ADS)
Siewert, Christoph; Bec, Jérémie; Krstulovic, Giorgio
2017-01-01
Motivated by systems in which droplets grow and shrink in a turbulence-driven supersaturation field, we investigate the problem of turbulent condensation in a general manner. Using direct numerical simulations we show that the turbulent fluctuations of the supersaturation field offer different conditions for the growth of droplets which evolve in time due to turbulent transport and mixing. Based on that, we propose a Lagrangian stochastic model for condensation and evaporation of small droplets in turbulent flows. It consists of a set of stochastic integro-differential equations for the joint evolution of the squared radius and the supersaturation along the droplet trajectories. The model has two parameters fixed by the total amount of water and the thermodynamic properties, as well as the Lagrangian integral timescale of the turbulent supersaturation. The model reproduces very well the droplet size distributions obtained from direct numerical simulations and their time evolution. A noticeable result is that, after a stage where the squared radius simply diffuses, the system converges exponentially fast to a statistical steady state independent of the initial conditions. The main mechanism involved in this convergence is a loss of memory induced by a significant number of droplets undergoing a complete evaporation before growing again. The statistical steady state is characterised by an exponential tail in the droplet mass distribution. These results reconcile those of earlier numerical studies, once these various regimes are considered.
Steady-state models of photosynthesis.
von Caemmerer, Susanne
2013-09-01
In the challenge to increase photosynthetic rate per leaf area mathematical models of photosynthesis can be used to help interpret gas exchange measurements made under different environmental conditions and predict underlying photosynthetic biochemistry. To do this successfully it is important to improve the modelling of temperature dependencies of CO₂ assimilation and gain better understanding of internal CO₂ diffusion limitations. Despite these shortcomings steady-state models of photosynthesis provide simple easy to use tools for thought experiments to explore photosynthetic pathway changes such as redirecting photorespiratory CO₂, inserting bicarbonate pumps into C₃ chloroplasts or inserting C₄ photosynthesis into rice. Here a number of models derived from the C₃ model by Farquhar, von Caemmerer and Berry are discussed and compared.
NASA Astrophysics Data System (ADS)
Jazaei, Farhad; Simpson, Matthew J.; Clement, T. Prabhakar
2017-01-01
The diffusion equation is one of the most commonly used models for describing environmental problems involving heat, solute, and water transport. A diffusive system can be either transient or steady state. When a system is transient, the dependent variable (e.g., temperature, concentration, or hydraulic head) varies with time; whereas at steady state, the temporal variations are negligible. Here we consider an intermediate state, called steady shape, corresponding to the situation where temporal variations in diffusive fluxes are negligible but the dependent variable may remain transient. We present a general theoretical framework for identifying steady shape conditions and propose a novel method for evaluating the time scale needed for a diffusive system to approach both steady shape and steady state conditions.
Inconsistencies in steady-state thermodynamics
NASA Astrophysics Data System (ADS)
Dickman, Ronald; Motai, Ricardo
2014-03-01
We address the issue of extending thermodynamics to nonequilibrium steady states. Using driven stochastic lattice gases, we ask whether consistent definitions of an effective chemical potential μ, and an effective temperature Te, are possible. μ and Te are determined via coexistence, i.e., zero flux of particles and energy between the driven system and a reservoir. In the lattice gas with nearest-neighbor exclusion, temperature is not relevant, and we find that the effective chemical potential, a function of density and drive strength, satisfies the zeroth law, and correctly predicts the densities of coexisting systems. In the Katz-Lebowitz-Spohn driven lattice gas both μ and Te need to be defined. We show analytically that in this case the zeroth law is violated for Metropolis exchange rates, and determine the size of the violations numerically. The zeroth law appears to be violated for generic exchange rates. Remarkably, the system-reservoir coupling proposed by Sasa and Tasaki [J. Stat. Phys. 125, 125 (2006), 10.1007/s10955-005-9021-7] is free of inconsistencies, and the zeroth law holds. This is because the rate depends only on the state of the donor system, and is independent of that of the acceptor.
Steady- and non-steady-state carbonate-silicate controls on atmospheric CO2
Sundquist, E.T.
1991-01-01
Two contrasting hypotheses have recently been proposed for the past long-term relation between atmospheric CO2 and the carbonate-silicate geochemical cycle. One approach (Berner, 1990) suggests that CO2 levels have varied in a manner that has maintained chemical weathering and carbonate sedimentation at a steady state with respect to tectonically controlled decarbonation reactions. A second approach (Raymo et al., 1988), applied specificlly to the late Cenozoic, suggests a decrease in CO2 caused by an uplift-induced increase in chemical weathering, without regard to the rate of decarbonation. According to the steady-state (first) hypothesis, increased weathering and carbonate sedimentation are generally associated with increasing atmospheric CO2, whereas the uplift (second) hypothesis implies decreasing CO2 under the same conditions. An ocean-atmosphere-sediment model has been used to assess the response of atmospheric CO2 and carbonate sedimentation to global perturbations in chemical weathering and decarbonation reactions. Although this assessment is theoretical and cannot yet be related to the geologic record, the model simulations compare steady-state and non-steady-state carbonate-silicate cycle response. The e-fold response time of the 'CO2-weathering' feedback mechanism is between 300 and 400 ka. The response of carbonate sedimentation is much more rapid. These response times provide a measure of the strength of steady-state assumptions, and imply that certain systematic relations are sustained throughout steady-state and non-steady-state scenarios for the carbonate-silicate cycle. The simulations suggest that feedbacks can maintain the system near a steady state, but that non-steady-state effects may contribute to long-term trends. The steady-state and uplift hypotheses are not necessarily incompatible over time scales of a few million years. ?? 1991.
Steady-state and non-steady state operation of counter-current chromatography devices.
Kostanyan, Artak E; Ignatova, Svetlana N; Sutherland, Ian A; Hewitson, Peter; Zakhodjaeva, Yulya A; Erastov, Andrey A
2013-11-01
Different variants of separation processes based on steady-state (continuous sample loading) and non-steady state (batch) operating modes of CCC columns have been analyzed and compared. The analysis is carried out on the basis of the modified equilibrium cell model, which takes into account both mechanisms of band broadening - interphase mass transfer and axial mixing. A full theoretical treatment of the intermittent counter-current chromatography with short sample loading time is performed. Analytical expressions are presented allowing the simulation of the intermittent counter-current chromatography separations for various experimental conditions. Chromatographic and extraction separations have been compared and advantages and disadvantages of the two methods have been evaluated. Further technical development of the CCC machines to implement counter-current extraction separations is considered.
Gallegos, F.R.
1996-06-01
The Radiation Security System (RSS) at the Los Alamos Neutron Science Center (LANSCE) provides personnel protection from prompt radiation due to accelerated beam. Active instrumentation, such as the Beam Current Limiter, is a component of the RSS. The current limiter is designed to limit the average current in a beam line below a specific level, thus minimizing the maximum current available for a beam spill accident. The beam current limiter is a self-contained, electrically isolated toroidal beam transformer which continuously monitors beam current. It is designed as fail-safe instrumentation. The design philosophy, hardware design, operation, and limitations of the device are described.
Gallegos, F.R.
1997-01-01
The Radiation Security System (RSS) at the Los Alamos Neutron Science Center (LANSCE) provides personnel protection from prompt radiation due to accelerated beam. Active instrumentation, such as the beam current limiter, is a component of the RSS. The current limiter is designed to limit the average current in a beamline below a specific level, thus minimizing the maximum current available for a beam spill accident. The beam current limiter is a self-contained, electrically isolated toroidal beam transformer which continuously monitors beam current. It is designed as fail-safe instrumentation. The design philosophy, hardware design, operation, and limitations of the device are described. {copyright} {ital 1997 American Institute of Physics.}
Steady State Vapor Bubble in Pool Boiling
Zou, An; Chanana, Ashish; Agrawal, Amit; Wayner, Peter C.; Maroo, Shalabh C.
2016-01-01
Boiling, a dynamic and multiscale process, has been studied for several decades; however, a comprehensive understanding of the process is still lacking. The bubble ebullition cycle, which occurs over millisecond time-span, makes it extremely challenging to study near-surface interfacial characteristics of a single bubble. Here, we create a steady-state vapor bubble that can remain stable for hours in a pool of sub-cooled water using a femtosecond laser source. The stability of the bubble allows us to measure the contact-angle and perform in-situ imaging of the contact-line region and the microlayer, on hydrophilic and hydrophobic surfaces and in both degassed and regular (with dissolved air) water. The early growth stage of vapor bubble in degassed water shows a completely wetted bubble base with the microlayer, and the bubble does not depart from the surface due to reduced liquid pressure in the microlayer. Using experimental data and numerical simulations, we obtain permissible range of maximum heat transfer coefficient possible in nucleate boiling and the width of the evaporating layer in the contact-line region. This technique of creating and measuring fundamental characteristics of a stable vapor bubble will facilitate rational design of nanostructures for boiling enhancement and advance thermal management in electronics. PMID:26837464
Maximal lactate steady state in Judo
de Azevedo, Paulo Henrique Silva Marques; Pithon-Curi, Tania; Zagatto, Alessandro Moura; Oliveira, João; Perez, Sérgio
2014-01-01
Summary Background: the purpose of this study was to verify the validity of respiratory compensation threshold (RCT) measured during a new single judo specific incremental test (JSIT) for aerobic demand evaluation. Methods: to test the validity of the new test, the JSIT was compared with Maximal Lactate Steady State (MLSS), which is the gold standard procedure for aerobic demand measuring. Eight well-trained male competitive judo players (24.3 ± 7.9 years; height of 169.3 ± 6.7cm; fat mass of 12.7 ± 3.9%) performed a maximal incremental specific test for judo to assess the RCT and performed on 30-minute MLSS test, where both tests were performed mimicking the UchiKomi drills. Results: the intensity at RCT measured on JSIT was not significantly different compared to MLSS (p=0.40). In addition, it was observed high and significant correlation between MLSS and RCT (r=0.90, p=0.002), as well as a high agreement. Conclusions: RCT measured during JSIT is a valid procedure to measure the aerobic demand, respecting the ecological validity of Judo. PMID:25332923
Steady State Vapor Bubble in Pool Boiling.
Zou, An; Chanana, Ashish; Agrawal, Amit; Wayner, Peter C; Maroo, Shalabh C
2016-02-03
Boiling, a dynamic and multiscale process, has been studied for several decades; however, a comprehensive understanding of the process is still lacking. The bubble ebullition cycle, which occurs over millisecond time-span, makes it extremely challenging to study near-surface interfacial characteristics of a single bubble. Here, we create a steady-state vapor bubble that can remain stable for hours in a pool of sub-cooled water using a femtosecond laser source. The stability of the bubble allows us to measure the contact-angle and perform in-situ imaging of the contact-line region and the microlayer, on hydrophilic and hydrophobic surfaces and in both degassed and regular (with dissolved air) water. The early growth stage of vapor bubble in degassed water shows a completely wetted bubble base with the microlayer, and the bubble does not depart from the surface due to reduced liquid pressure in the microlayer. Using experimental data and numerical simulations, we obtain permissible range of maximum heat transfer coefficient possible in nucleate boiling and the width of the evaporating layer in the contact-line region. This technique of creating and measuring fundamental characteristics of a stable vapor bubble will facilitate rational design of nanostructures for boiling enhancement and advance thermal management in electronics.
Steady state volcanism - Evidence from eruption histories of polygenetic volcanoes
NASA Technical Reports Server (NTRS)
Wadge, G.
1982-01-01
Cumulative volcano volume curves are presented as evidence for steady-state behavior at certain volcanoes and to develop a model of steady-state volcanism. A minimum criteria of five eruptions over a year was chosen to characterize a steady-state volcano. The subsequent model features a constant head of magmatic pressure from a reservoir supplied from depth, a sawtooth curve produced by the magma arrivals or discharge from the subvolcanic reservoir, large volume eruptions with long repose periods, and conditions of nonsupply of magma. The behavior of Mts. Etna, Nyamuragira, and Kilauea are described and show continuous levels of plasma output resulting in cumulative volume increases. Further discussion is made of steady-state andesitic and dacitic volcanism, long term patterns of the steady state, and magma storage, and the lack of a sufficient number of steady-state volcanoes in the world is taken as evidence that further data is required for a comprehensive model.
The steady-state assumption in oscillating and growing systems.
Reimers, Alexandra-M; Reimers, Arne C
2016-10-07
The steady-state assumption, which states that the production and consumption of metabolites inside the cell are balanced, is one of the key aspects that makes an efficient analysis of genome-scale metabolic networks possible. It can be motivated from two different perspectives. In the time-scales perspective, we use the fact that metabolism is much faster than other cellular processes such as gene expression. Hence, the steady-state assumption is derived as a quasi-steady-state approximation of the metabolism that adapts to the changing cellular conditions. In this article we focus on the second perspective, stating that on the long run no metabolite can accumulate or deplete. In contrast to the first perspective it is not immediately clear how this perspective can be captured mathematically and what assumptions are required to obtain the steady-state condition. By presenting a mathematical framework based on the second perspective we demonstrate that the assumption of steady-state also applies to oscillating and growing systems without requiring quasi-steady-state at any time point. However, we also show that the average concentrations may not be compatible with the average fluxes. In summary, we establish a mathematical foundation for the steady-state assumption for long time periods that justifies its successful use in many applications. Furthermore, this mathematical foundation also pinpoints unintuitive effects in the integration of metabolite concentrations using nonlinear constraints into steady-state models for long time periods.
Defining Features of Steady-State Timbres
NASA Astrophysics Data System (ADS)
Hall, Michael D.
1995-01-01
Three experiments were conducted to define steady -state features of timbre for a group of well-trained musicians. Experiment 1 evaluated whether or not pairs of three critical dimensions of timbre--spectral slope (6 or 12 dB/octave), formant structure (/a/ or /i/ vowel), and inharmonicity of partials (harmonic or inharmonic)--were processed in a separable or integral fashion. Accuracy and speed for classification of values along one dimension were examined under different conditions of variability along a second dimension (fixed, correlated, or orthogonal). Spectral slope and formant structure were integral, with classification speed for the target dimension depending upon variability along the orthogonal dimension. In contrast, evidence of asymmetric separability was obtained for inharmonicity. Classification speed for slope and formant structure did not depend on inharmonicity, whereas RT for the target dimension of inharmonicity was strongly influenced by variability along either slope or formant structure. Since the results of Experiment 1 provided a basis for manipulating spectral slope and formant structure as a single feature, these dimensions were correlated in Experiment 2. Subjects searched for targets containing potential features of timbre within arrays of 1-4 inharmonic distractor pitches. Distractors were homogeneous with respect to the dimensions of timbre. When targets had /a/ formants with shallow spectral slopes, search time increased nonlinearly with array size in a manner consistent with the parallel processing of items, and thus feature search. Feature search was not obtained for targets with /i/ formants and steep slopes. Thus, the feature was coded as the presence or absence of /a/ formants with shallow spectral slopes. A search task using heterogeneous distractor values along slope/formant structure was used in Experiment 3 to evaluate whether or not the feature of timbre and pitch were automatically conjoined (integral). Search times for
Ecological Implications of Steady State and Nonsteady State Bioaccumulation Models.
McLeod, Anne M; Paterson, Gordon; Drouillard, Ken G; Haffner, G Douglas
2016-10-18
Accurate predictions on the bioaccumulation of persistent organic pollutants (POPs) are critical for hazard and ecosystem health assessments. Aquatic systems are influenced by multiple stressors including climate change and species invasions and it is important to be able to predict variability in POP concentrations in changing environments. Current steady state bioaccumulation models simplify POP bioaccumulation dynamics, assuming that pollutant uptake and elimination processes become balanced over an organism's lifespan. These models do not consider the complexity of dynamic variables such as temperature and growth rates which are known to have the potential to regulate bioaccumulation in aquatic organisms. We contrast a steady state (SS) bioaccumulation model with a dynamic nonsteady state (NSS) model and a no elimination (NE) model. We demonstrate that both the NSS and the NE models are superior at predicting both average concentrations as well as variation in POPs among individuals. This comparison demonstrates that temporal drivers, such as environmental fluctuations in temperature, growth dynamics, and modified food-web structure strongly determine contaminant concentrations and variability in a changing environment. These results support the recommendation of the future development of more dynamic, nonsteady state bioaccumulation models to predict hazard and risk assessments in the Anthropocene.
The status of the LANSCE refurbishment project (LANSCE-R)
Erickson, John Leonard; Jones, Kevin; Streve, Michael
2008-01-01
The Los Alamos Neutron Science Center (LANSCE) accelerator is an 800-MeV proton linac that drives user facilities for isotope production, proton radiography, ultra-cold neutrons, weapons neutron research and various sciences using neutron scattering. The LANSCE Refurbishment Project (LANSCE-R) is an ambitious project to refurbish key elements of the LANSCE accelerator that are becoming obsolete or nearing end-of-life. The conceptual design phase for the project is funded and underway. The 5 year, $170M (US) project will enable future decades of reliable, high-performance operation. It will replace a substantial fraction of the radio-frequency power systems (gridded tubes and klystrons) with modern systems, completely refurbish the original accelerator control and timing systems, replace obsolete diagnostic devices, and modernize other ancillary systems. An overview of the LANSCE-R project will be presented. The functional and operating requirements will be discussed, the proposed technical solutions presented, and the plan for successful project execution while meeting annual customer expectations for beam delivery will be reviewed.
A Note on Equations for Steady-State Optimal Landscapes
Liu, H.H.
2010-06-15
Based on the optimality principle (that the global energy expenditure rate is at its minimum for a given landscape under steady state conditions) and calculus of variations, we have derived a group of partial differential equations for describing steady-state optimal landscapes without explicitly distinguishing between hillslopes and channel networks. Other than building on the well-established Mining's equation, this work does not rely on any empirical relationships (such as those relating hydraulic parameters to local slopes). Using additional constraints, we also theoretically demonstrate that steady-state water depth is a power function of local slope, which is consistent with field data.
Steady-state decoupling and design of linear multivariable systems
NASA Technical Reports Server (NTRS)
Thaler, G. J.
1974-01-01
A constructive criterion for decoupling the steady states of a linear time-invariant multivariable system is presented. This criterion consists of a set of inequalities which, when satisfied, will cause the steady states of a system to be decoupled. Stability analysis and a new design technique for such systems are given. A new and simple connection between single-loop and multivariable cases is found. These results are then applied to the compensation design for NASA STOL C-8A aircraft. Both steady-state decoupling and stability are justified through computer simulations.
[Auditory steady-state responses--the state of art].
Szymańska, Anna; Gryczyński, Maciej; Pajor, Anna
2010-01-01
The auditory steady-state responses (ASSR) is quite a new method of electrophysiological threshold estimation with no clinical standards. It was the aim of this study to review practical and theoretical thesis of ASSR and mention recent recommendations and achievements of this technique. The most common application of ASSR is diagnosis of hearing loss in children together with ABR test. In this paper we mentioned information about influence of physiological factors (age, sex, state of arousal, handedness) and type of recording technique (electrodes placement, air and bone stimulation, occlusion effect, amplitude and frequency stimulation, multiple or single frequency stimulation, dichotic and monotic recording technique and type of hearing loss) on ASSR. We conclude that putting ASSR in clinical use as an standardized method it is necessary to do research with numerous groups of patients using the same equipment and parameters of tests.
On the time to steady state: insights from numerical modeling
NASA Astrophysics Data System (ADS)
Goren, L.; Willett, S.; McCoy, S. W.; Perron, J.
2013-12-01
How fast do fluvial landscapes approach steady state after an application of tectonic or climatic perturbation? While theory and some numerical models predict that the celerity of the advective wave (knickpoint) controls the response time for perturbations, experiments and other landscape evolution models demonstrate that the time to steady state is much longer than the theoretically predicted response time. We posit that the longevity of transient features and the time to steady state are controlled by the stability of the topology and geometry of channel networks. Evolution of a channel network occurs by a combination of discrete capture events and continuous migration of water divides, processes, which are difficult to represent accurately in landscape evolution models. We therefore address the question of the time to steady state using the DAC landscape evolution model that solves accurately for the location of water divides, using a combination of analytical solution for hillslopes and low-order channels together with a numerical solution for higher order channels. DAC also includes an explicit capture criterion. We have tested fundamental predictions from DAC and show that modeled networks reproduce natural network characteristics such as the Hack's exponent and coefficient and the fractal dimension. We define two steady-state criteria: a topographic steady state, defined by global, pointwise steady elevation, and a topological steady state defined as the state in which no further reorganization of the drainage network takes place. Analyzing block uplift simulations, we find that the time to achieve either topographic or topological steady state exceeds by an order of magnitude the theoretical response time of the fluvial network. The longevity of the transient state is the result of the area feedback, by which, migration of a divide changes the local contributing area. This change propagates downstream as a slope adjustment, forcing further divide migrations
An Operational Definition of the Steady State in Enzyme Kinetics.
ERIC Educational Resources Information Center
Barnsley, E. A.
1990-01-01
The Briggs-Haldane assumption is used as the basis for the development of a kinetic model for enzyme catalysis. An alternative definition of the steady state and examples of realistic mechanisms are provided. (KR)
The Enlisted Steady State-Simulation (ESS-SIM) Tool
2014-07-01
The Enlisted Steady State-Simulation ( ESS -SIM) Tool David M. Rodney • Peggy A. Golfin • Molly F. McIntosh DIM-2014-U-007587-Final July 2014 This...situation. We built and made use of a simulation model, ESS -Sim (Enlisted Steady- State Simulation), to obtain insights into attainable levels of...fleet manning and estimate the impact of policy changes on fleet man- ning. This information memorandum describes this model. Model overview We built ESS
Multiple steady states in coupled flow tank reactors
NASA Astrophysics Data System (ADS)
Hunt, Katharine L. C.; Kottalam, J.; Hatlee, Michael D.; Ross, John
1992-05-01
Coupling between continuous-flow, stirred tank reactors (CSTR's), each having multiple steady states, can produce new steady states with different concentrations of the chemical species in each of the coupled tanks. In this work, we identify a kinetic potential ψ that governs the deterministic time evolution of coupled tank reactors, when the reaction mechanism permits a single-variable description of the states of the individual tanks; examples include the iodate-arsenous acid reaction, a cubic model suggested by Noyes, and two quintic models. Stable steady states correspond to minima of ψ, and unstable steady states to maxima or saddle points; marginally stable states typically correspond to saddle-node points. We illustrate the variation in ψ due to changes in the rate constant for external material intake (k0) and for exchange between tanks (kx). For fixed k0 values, we analyze the changes in numbers and types of steady states as kx increases from zero. We show that steady states disappear by pairwise coalescence; we also show that new steady states may appear with increasing kx, when the reaction mechanism is sufficiently complex. For fixed initial conditions, the steady state ultimately reached in a mixing experiment may depend on the exchange rate constant as a function of time, kx(t) : Adiabatic mixing is obtained in the limit of slow changes in kx(t) and instantaneous mixing in the limit as kx(t)→∞ while t remains small. Analyses based on the potential ψ predict the outcome of mixing experiments for arbitrary kx(t). We show by explicit counterexamples that a prior theory developed by Noyes does not correctly predict the instability points or the transitions between steady states of coupled tanks, to be expected in mixing experiments. We further show that the outcome of such experiments is not connected to the relative stability of steady states in individual tank reactors. We find that coupling may effectively stabilize the tanks. We provide
Numerical computation of steady-state acoustic disturbances in flow
NASA Technical Reports Server (NTRS)
Watson, W. R.; Myers, M. K.
1992-01-01
Two time domain methods for computing two dimensional steady-state acoustic disturbances propagating through internal subsonic viscous flow fields in the presence of variable area are investigated. The first method solves the Navier-Stokes equations for the combined steady and acoustic field together and subtracts the steady flow to obtain the acoustic field. The second method solves a system of perturbation equations to obtain the acoustic disturbances, making use of a separate steady flow computation as input to the system. In each case the periodic steady-state acoustic fluctuations are obtained numerically on a supercomputer using a second order unsplit explicit MacCormack predictor-corrector method. Results show that the first method is not very effective for computing acoustic disturbances of even moderate amplitude. It appears that more accurate steady flow algorithms are required for this method to succeed. On the other hand, linear and nonlinear acoustic disturbances extracted from the perturbation approach are shown to exhibit expected behavior for the problems considered. It is also found that inflow boundary conditions for an equivalent uniform duct can be successfully applied to a nonuniform duct to obtain steady-state acoustic disturbances.
The Energy Budget of Steady State Photosynthesis
Dr. David M. Kramer
2012-11-27
Progress is reported in addressing these questions: Why do hcef mutants have increased CEF1? Is increased CEF1 caused by elevated expression or altered regulation of CEF1 components? Which metabolic pools can be regulators of CEF1? Do metabolites influence CEF1 directly or indirectly? Which CEF1 pathways are activated in high CEF1 mutants? Is PQR a proton pump? Is elevated CEF1 activated by state transitions?
Structural simplification of chemical reaction networks in partial steady states.
Madelaine, Guillaume; Lhoussaine, Cédric; Niehren, Joachim; Tonello, Elisa
2016-11-01
We study the structural simplification of chemical reaction networks with partial steady state semantics assuming that the concentrations of some but not all species are constant. We present a simplification rule that can eliminate intermediate species that are in partial steady state, while preserving the dynamics of all other species. Our simplification rule can be applied to general reaction networks with some but few restrictions on the possible kinetic laws. We can also simplify reaction networks subject to conservation laws. We prove that our simplification rule is correct when applied to a module of a reaction network, as long as the partial steady state is assumed with respect to the complete network. Michaelis-Menten's simplification rule for enzymatic reactions falls out as a special case. We have implemented an algorithm that applies our simplification rules repeatedly and applied it to reaction networks from systems biology.
Poissonian steady states: from stationary densities to stationary intensities.
Eliazar, Iddo
2012-10-01
Markov dynamics are the most elemental and omnipresent form of stochastic dynamics in the sciences, with applications ranging from physics to chemistry, from biology to evolution, and from economics to finance. Markov dynamics can be either stationary or nonstationary. Stationary Markov dynamics represent statistical steady states and are quantified by stationary densities. In this paper, we generalize the notion of steady state to the case of general Markov dynamics. Considering an ensemble of independent motions governed by common Markov dynamics, we establish that the entire ensemble attains Poissonian steady states which are quantified by stationary Poissonian intensities and which hold valid also in the case of nonstationary Markov dynamics. The methodology is applied to a host of Markov dynamics, including Brownian motion, birth-death processes, random walks, geometric random walks, renewal processes, growth-collapse dynamics, decay-surge dynamics, Ito diffusions, and Langevin dynamics.
A simplified approach to estimating the maximal lactate steady state.
Snyder, A C; Woulfe, T; Welsh, R; Foster, C
1994-01-01
The exercise intensity associated with an elevated but stable blood lactate (HLa) concentration during constant load work (the maximal steady state, MSS) has received attention as a candidate for the "optimal" exercise intensity for endurance training. Identification of MSS ordinarily demands direct measurement of HLa or respiratory metabolism. The purpose of this study was to test the ability of heart rate (HR) to identify MSS during steady state exercise, similar to that used in conventional exercise prescription. Trained runners (n = 9) and cyclists (n = 12) performed incremental and steady state exercise. MSS was defined as the highest intensity in which blood lactate concentration increased < 1.0 mM from minutes 10 to 30. The next higher intensity workbout completed was defined as > MSS. HR models related to the presence or absence of steady state conditions were developed from the upper 95% confidence interval of MSS and the lower 95% confidence interval of > MSS. Cross validation of the model to predict MSS was performed using 21 running and 45 cycling exercise bouts in a separate group. Using the MSS upper 95% confidence interval model 84% and 76% of workbouts were correctly predicted in cyclists and runners, respectively. Using the > MSS lower 95% confidence interval model, 76% and 81% of workbouts were correctly predicted in cyclists and runners, respectively. Prediction errors tended to incorrectly predict non-steady state conditions when steady state had occurred (16/26) (62%). We conclude that use of these simple HR models may predict MSS with sufficient accuracy to be useful when direct HLa measurement is not available.
Steady-state error of a system with fuzzy controller.
Butkiewicz, B S
1998-01-01
We consider the problem of control error of a fuzzy system with feedback. The system consists of a plant, linear or nonlinear, fuzzy controller, and feedback loop. As controller we use both PD and PI fuzzy type controllers. We apply different t-norm and co-norm: logic, algebraic, Yager, Hamacher, bounded, drastic, etc. in the process of fuzzy reasoning. Triangular shape of membership functions is supposed, but we generalize the results obtained. Steady-state error of a system is calculated. We have obtained very interesting results. The steady-state error is identical for pairs of triangular t- and co-norms.
Mapping current fluctuations of stochastic pumps to nonequilibrium steady states
NASA Astrophysics Data System (ADS)
Rotskoff, Grant M.
2017-03-01
We show that current fluctuations in a stochastic pump can be robustly mapped to fluctuations in a corresponding time-independent nonequilibrium steady state. We thus refine a recently proposed mapping so that it ensures equivalence of not only the averages, but also optimal representation of fluctuations in currents and density. Our mapping leads to a natural decomposition of the entropy production in stochastic pumps similar to the "housekeeping" heat. As a consequence of the decomposition of entropy production, the current fluctuations in weakly perturbed stochastic pumps are shown to satisfy a universal bound determined by the steady state entropy production.
Descriptive Linear modeling of steady-state visual evoked response
NASA Technical Reports Server (NTRS)
Levison, W. H.; Junker, A. M.; Kenner, K.
1986-01-01
A study is being conducted to explore use of the steady state visual-evoke electrocortical response as an indicator of cognitive task loading. Application of linear descriptive modeling to steady state Visual Evoked Response (VER) data is summarized. Two aspects of linear modeling are reviewed: (1) unwrapping the phase-shift portion of the frequency response, and (2) parsimonious characterization of task-loading effects in terms of changes in model parameters. Model-based phase unwrapping appears to be most reliable in applications, such as manual control, where theoretical models are available. Linear descriptive modeling of the VER has not yet been shown to provide consistent and readily interpretable results.
Analytic Steady-State Accuracy of a Spacecraft Attitude Estimator
NASA Technical Reports Server (NTRS)
Markley, F. Landis
2000-01-01
This paper extends Farrenkopf's analysis of a single-axis spacecraft attitude estimator using gyro and angle sensor data to include the angle output white noise of a rate-integrating gyro. Analytic expressions are derived for the steady-state pre-update and post-update angle and drift bias variances and for the state update equations. It is shown that only part of the state update resulting from the angle sensor measurement is propagated to future times.
Density Functional Theory for Steady-State Nonequilibrium Molecular Junctions
Liu, Shuanglong; Nurbawono, Argo; Zhang, Chun
2015-01-01
We present a density functional theory (DFT) for steady-state nonequilibrium quantum systems such as molecular junctions under a finite bias. Based on the steady-state nonequilibrium statistics that maps nonequilibrium to an effective equilibrium, we show that ground-state DFT (GS-DFT) is not applicable in this case and two densities, the total electron density and the density of current-carrying electrons, are needed to uniquely determine the properties of the corresponding nonequilibrium system. A self-consistent mean-field approach based on two densities is then derived. The theory is implemented into SIESTA computational package and applied to study nonequilibrium electronic/transport properties of a realistic carbon-nanotube (CNT)/Benzene junction. Results obtained from our steady-state DFT (SS-DFT) are compared with those of conventional GS-DFT based transport calculations. We show that SS-DFT yields energetically more stable nonequilibrium steady state, predicts significantly lower electric current, and is able to produce correct electronic structures in local equilibrium under a limiting case. PMID:26472080
Basin stability measure of different steady states in coupled oscillators
Rakshit, Sarbendu; Bera, Bidesh K.; Majhi, Soumen; Hens, Chittaranjan; Ghosh, Dibakar
2017-01-01
In this report, we investigate the stabilization of saddle fixed points in coupled oscillators where individual oscillators exhibit the saddle fixed points. The coupled oscillators may have two structurally different types of suppressed states, namely amplitude death and oscillation death. The stabilization of saddle equilibrium point refers to the amplitude death state where oscillations are ceased and all the oscillators converge to the single stable steady state via inverse pitchfork bifurcation. Due to multistability features of oscillation death states, linear stability theory fails to analyze the stability of such states analytically, so we quantify all the states by basin stability measurement which is an universal nonlocal nonlinear concept and it interplays with the volume of basins of attractions. We also observe multi-clustered oscillation death states in a random network and measure them using basin stability framework. To explore such phenomena we choose a network of coupled Duffing-Holmes and Lorenz oscillators which are interacting through mean-field coupling. We investigate how basin stability for different steady states depends on mean-field density and coupling strength. We also analytically derive stability conditions for different steady states and confirm by rigorous bifurcation analysis. PMID:28378760
Pre-Steady-State Decoding of the Bicoid Morphogen Gradient
Bergmann, Sven; Sandler, Oded; Sberro, Hila; Shnider, Sara; Schejter, Eyal; Shilo, Ben-Zion; Barkai, Naama
2007-01-01
Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior–posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage. PMID:17298180
Steady-State Multiplicity Features of Chemically Reacting Systems.
ERIC Educational Resources Information Center
Luss, Dan
1986-01-01
Analyzes steady-state multiplicity in chemical reactors, focusing on the use of two mathematical tools, namely, the catastrophe theory and the singularity theory with a distinguished parameter. These tools can be used to determine the maximum number of possible solutions and the different types of bifurcation diagrams. (JN)
Pressure updating methods for the steady-state fluid equations
NASA Technical Reports Server (NTRS)
Fiterman, A.; Turkel, E.; Vatsa, V.
1995-01-01
We consider the steady state equations for a compressible fluid. Since we wish to solve for a range of speeds we must consider the equations in conservation form. For transonic speeds these equations are of mixed type. Hence, the usual approach is to add time derivatives to the steady state equations and then march these equations in time. One then adds a time derivative of the density to the continuity equation, a derivative of the momentum to the momentum equation and a derivative of the total energy to the energy equation. This choice is dictated by the time consistent equations. However, since we are only interested in the steady state this is not necessary. Thus we shall consider the possibility of adding a time derivative of the pressure to the continuity equation and similar modifications for the energy equation. This can then be generalized to adding combinations of time derivatives to each equation since these vanish in the steady state. When using acceleration techniques such as residual smoothing, multigrid, etc. these are applied to the pressure rather than the density. Hence, the code duplicates the behavior of the incompressible equations for low speeds.
STEADY-STATE MODEL OF SOLAR WIND ELECTRONS REVISITED
Yoon, Peter H.; Kim, Sunjung; Choe, G. S.
2015-10-20
In a recent paper, Kim et al. put forth a steady-state model for the solar wind electrons. The model assumed local equilibrium between the halo electrons, characterized by an intermediate energy range, and the whistler-range fluctuations. The basic wave–particle interaction is assumed to be the cyclotron resonance. Similarly, it was assumed that a dynamical steady state is established between the highly energetic superhalo electrons and high-frequency Langmuir fluctuations. Comparisons with the measured solar wind electron velocity distribution function (VDF) during quiet times were also made, and reasonable agreements were obtained. In such a model, however, only the steady-state solution for the Fokker–Planck type of electron particle kinetic equation was considered. The present paper complements the previous analysis by considering both the steady-state particle and wave kinetic equations. It is shown that the model halo and superhalo electron VDFs, as well as the assumed wave intensity spectra for the whistler and Langmuir fluctuations, approximately satisfy the quasi-linear wave kinetic equations in an approximate sense, thus further validating the local equilibrium model constructed in the paper by Kim et al.
CONTROL OF CRYPTOSPORIDIUM OOCYSTS BY STEADY-STATE CONVENTIONAL TREATMENT
Pilot-scale experiments have been performed to assess the ability of conventional treatment to control Cryptosporidium oocysts under steady-state conditions. The work was performed with a pilot plant that was designed to minimize flow rates and, as a result, the number of oocyst...
Steady-State Pharmacokinetics of Bupropion SR in Juvenile Patients
ERIC Educational Resources Information Center
Daviss, W. Burleson; Perel, James M.; Rudolph, George R.; Axelson, David A.; Gilchrist, Richard; Nuss, Sharon; Birmaher, Boris; Brent, David A.
2005-01-01
Objective: To examine the steady-state pharmacokinetic properties of bupropion sustained release (SR) and their potential developmental differences in youths. Method: Eleven boys and eight girls aged 11 to 17 years old were prescribed bupropion SR monotherapy for attention-deficit/hyperactivity disorder (n = 16) and/or depressive disorders (n =…
The concave river long profile: a morphodynamic steady state?
NASA Astrophysics Data System (ADS)
Blom, A.
2011-12-01
By definition, a morphodynamic steady state is governed by a spatially constant sediment transport rate. As the sediment transport rate is a function of shear stress associated with skin friction, the morphodynamic steady state has been considered to be governed by a spatially constant bed slope. For this reason, the typical concave river long profile has been considered to be a quasi-steady state. The river's steady state has been considered to be one with a spatially constant bed slope, with tributaries inducing a stepwise decrease in bed slope in streamwise direction. Yet, for the sediment transport rate to be spatially constant, it rather is the product of water surface slope and water depth associated with skin friction that needs to be constant. This implies that physical mechanisms that induce streamwise variation in the sediment transport rate can be compensated by a streamwise variation in bed slope so as to guarantee a spatially constant sediment transport rate. Following the river course, such physical mechanisms can be bedrock exposure, partial transport, and a spatially lagging bedform growth. At locations where tributaries increase the water discharge, the above mechanisms cause the river bed profile to be upward concave over a significant reach. At bifucations or at locations where river widening prevails, the river bed profile is upward convex.
Combined Steady-State and Dynamic Heat Exchanger Experiment
ERIC Educational Resources Information Center
Luyben, William L.; Tuzla, Kemal; Bader, Paul N.
2009-01-01
This paper describes a heat-transfer experiment that combines steady-state analysis and dynamic control. A process-water stream is circulated through two tube-in-shell heat exchangers in series. In the first, the process water is heated by steam. In the second, it is cooled by cooling water. The equipment is pilot-plant size: heat-transfer areas…
Equilibrium Binding and Steady-State Enzyme Kinetics.
ERIC Educational Resources Information Center
Dunford, H. Brian
1984-01-01
Points out that equilibrium binding and steady-state enzyme kinetics have a great deal in common and that related equations and error analysis can be cast in identical forms. Emphasizes that if one type of problem solution is taught, the other is also taught. Various methods of data analysis are evaluated. (JM)
Identification of enzyme inhibitory mechanisms from steady-state kinetics.
Fange, David; Lovmar, Martin; Pavlov, Michael Y; Ehrenberg, Måns
2011-09-01
Enzyme inhibitors are used in many areas of the life sciences, ranging from basic research to the combat of disease in the clinic. Inhibitors are traditionally characterized by how they affect the steady-state kinetics of enzymes, commonly analyzed on the assumption that enzyme-bound and free substrate molecules are in equilibrium. This assumption, implying that an enzyme-bound substrate molecule has near zero probability to form a product rather than dissociate, is valid only for very inefficient enzymes. When it is relaxed, more complex but also more information-rich steady-state kinetics emerges. Although solutions to the general steady-state kinetics problem exist, they are opaque and have been of limited help to experimentalists. Here we reformulate the steady-state kinetics of enzyme inhibition in terms of new parameters. These allow for assessment of ambiguities of interpretation due to kinetic scheme degeneracy and provide an intuitively simple way to analyze experimental data. We illustrate the method by concrete examples of how to assess scheme degeneracy and obtain experimental estimates of all available rate and equilibrium constants. We suggest simple, complementary experiments that can remove ambiguities and greatly enhance the accuracy of parameter estimation.
Steady States of the Parametric Rotator and Pendulum
ERIC Educational Resources Information Center
Bouzas, Antonio O.
2010-01-01
We discuss several steady-state rotation and oscillation modes of the planar parametric rotator and pendulum with damping. We consider a general elliptic trajectory of the suspension point for both rotator and pendulum, for the latter at an arbitrary angle with gravity, with linear and circular trajectories as particular cases. We treat the…
Steady State Load Characterization Fact Sheet: 2012 Chevy Volt
Scoffield, Don
2015-03-01
This fact sheet characterizes the steady state charging behavior of a 2012 Chevy Volt. Both level 1 charging (120 volt) and level 2 charging (208 volts) is investigated. This fact sheet contains plots of efficiency, power factor, and current harmonics as vehicle charging is curtailed. Prominent current harmonics are also displayed in a histogram for various charge rates.
Steady-State Squeezing in the Micromaser Cavity Field
NASA Technical Reports Server (NTRS)
Nayak, N.
1996-01-01
It is shown that the radiation field in the presently operated micromaser cavity may be squeezed when pumped with polarized atoms. The squeezing is in the steady state field corresponding to the action similar to that of the conventional micromaser, with the effect of cavity dissipation during entire t(sub c) = tau + t(sub cav).
Typical pure nonequilibrium steady states and irreversibility for quantum transport.
Monnai, Takaaki; Yuasa, Kazuya
2016-07-01
It is known that each single typical pure state in an energy shell of a large isolated quantum system well represents a thermal equilibrium state of the system. We show that such typicality holds also for nonequilibrium steady states (NESS's). We consider a small quantum system coupled to multiple infinite reservoirs. In the long run, the total system reaches a unique NESS. We identify a large Hilbert space from which pure states of the system are to be sampled randomly and show that the typical pure states well describe the NESS. We also point out that the irreversible relaxation to the unique NESS is important to the typicality of the pure NESS's.
Multiplying steady-state culture in multi-reactor system.
Erm, Sten; Adamberg, Kaarel; Vilu, Raivo
2014-11-01
Cultivation of microorganisms in batch experiments is fast and economical but the conditions therein change constantly, rendering quantitative data interpretation difficult. By using chemostat with controlled environmental conditions the physiological state of microorganisms is fixed; however, the unavoidable stabilization phase makes continuous methods resource consuming. Material can be spared by using micro scale devices, which however have limited analysis and process control capabilities. Described herein are a method and a system combining the high throughput of batch with the controlled environment of continuous cultivations. Microorganisms were prepared in one bioreactor followed by culture distribution into a network of bioreactors and continuation of independent steady state experiments therein. Accelerostat cultivation with statistical analysis of growth parameters demonstrated non-compromised physiological state following distribution, thus the method effectively multiplied steady state culture of microorganisms. The theoretical efficiency of the system was evaluated in inhibitory compound analysis using repeated chemostat to chemostat transfers.
Steady state volcanism: Evidence from eruption histories of polygenetic volcanoes
Wadge, G.
1982-05-10
Some volcanoes erupt magma at average rates which are constant over periods of many years, even through this magma may appear in a complex series of eruptions. This constancy of output is tested by construction of a curve of cumulative volume of erupted magma, which is linear for steady state volcanism, and whose gradient defines the steady state rate Q/sub s/s. The assumption is made that Q/sub s/s is the rate at which magma is supplied to these polygenetic volcanoes. Five general types of eruptive behavior can be distinguished from the cumulative volume studied. These types are interpreted in terms of a simple model of batches of magma rising buoyantly through the crust and interacting with a small-capacity subvolcanic magma reservoir. Recognition of previous steady state behavior at a volcano may enable the cumulative volume curve to be used empirically as a constraint on the timing and volume of the next eruption. The steady state model thus has a limited predictive capability. With the exception of Kilauea (O/sub s/s = 4m/sup 3/ s/sup -1/) all the identified steady state volcanoes have values of Q/sub s/s of a few tenths of one cubic meter per second. These rates are consistent with the minimum flux rates required by theoretical cooling models of batches of magma traversing the crust. The similarity of these Q/sub s/s values of volcanoes (producing basalt, andesite, and dacite magmas) in very different tectonic settings suggests that the common factors of crustal buoyancy forces and the geotherm-controlled cooling rates control the dynamics of magma supply through the crust. Long-term dormancy at active volcanoes may be a manifestation of the steady accumulation of magma in large crustal reservoirs, a process that complements the intermittent periods of steady state output at the surface. This possibility has several implications, the most important of which is that it provides a constraint on the supply rate of new magma to the bases of plutons.
Simulations of KSTAR high performance steady state operation scenarios
NASA Astrophysics Data System (ADS)
Na, Yong-Su; Kessel, C. E.; Park, J. M.; Yi, Sumin; Becoulet, A.; Sips, A. C. C.; Kim, J. Y.
2009-11-01
We report the results of predictive modelling of high performance steady state operation scenarios in KSTAR. Firstly, the capabilities of steady state operation are investigated with time-dependent simulations using a free-boundary plasma equilibrium evolution code coupled with transport calculations. Secondly, the reproducibility of high performance steady state operation scenarios developed in the DIII-D tokamak, of similar size to that of KSTAR, is investigated using the experimental data taken from DIII-D. Finally, the capability of ITER-relevant steady state operation is investigated in KSTAR. It is found that KSTAR is able to establish high performance steady state operation scenarios; βN above 3, H98(y, 2) up to 2.0, fBS up to 0.76 and fNI equals 1.0. In this work, a realistic density profile is newly introduced for predictive simulations by employing the scaling law of a density peaking factor. The influence of the current ramp-up scenario and the transport model is discussed with respect to the fusion performance and non-inductive current drive fraction in the transport simulations. As observed in the experiments, both the heating and the plasma current waveforms in the current ramp-up phase produce a strong effect on the q-profile, the fusion performance and also on the non-inductive current drive fraction in the current flattop phase. A criterion in terms of qmin is found to establish ITER-relevant steady state operation scenarios. This will provide a guideline for designing the current ramp-up phase in KSTAR. It is observed that the transport model also affects the predictive values of fusion performance as well as the non-inductive current drive fraction. The Weiland transport model predicts the highest fusion performance as well as non-inductive current drive fraction in KSTAR. In contrast, the GLF23 model exhibits the lowest ones. ITER-relevant advanced scenarios cannot be obtained with the GLF23 model in the conditions given in this work. Finally
Simulations of KSTAR high performance steady state operation scenarios
Na, Y S; Kessel, C. E.; Park, Jin Myung; Yi, Sumin; Becoulet, A.; Sips, A C C; Kim, J Y
2009-01-01
We report the results of predictive modelling of high performance steady state operation scenarios in KSTAR. Firstly, the capabilities of steady state operation are investigated with time-dependent simulations using a free-boundary plasma equilibrium evolution code coupled with transport calculations. Secondly, the reproducibility of high performance steady state operation scenarios developed in the DIII-D tokamak, of similar size to that of KSTAR, is investigated using the experimental data taken from DIII-D. Finally, the capability of ITER-relevant steady state operation is investigated in KSTAR. It is found that KSTAR is able to establish high performance steady state operation scenarios; beta(N) above 3, H-98(y, 2) up to 2.0, f(BS) up to 0.76 and f(NI) equals 1.0. In this work, a realistic density profile is newly introduced for predictive simulations by employing the scaling law of a density peaking factor. The influence of the current ramp-up scenario and the transport model is discussed with respect to the fusion performance and non-inductive current drive fraction in the transport simulations. As observed in the experiments, both the heating and the plasma current waveforms in the current ramp-up phase produce a strong effect on the q-profile, the fusion performance and also on the non-inductive current drive fraction in the current flattop phase. A criterion in terms of q(min) is found to establish ITER-relevant steady state operation scenarios. This will provide a guideline for designing the current ramp-up phase in KSTAR. It is observed that the transport model also affects the predictive values of fusion performance as well as the non-inductive current drive fraction. The Weiland transport model predicts the highest fusion performance as well as non-inductive current drive fraction in KSTAR. In contrast, the GLF23 model exhibits the lowest ones. ITER-relevant advanced scenarios cannot be obtained with the GLF23 model in the conditions given in this work
Nonequilibrium Steady State Thermodynamics and Fluctuations for Stochastic Systems
NASA Astrophysics Data System (ADS)
Taniguchi, Tooru; Cohen, E. G. D.
2008-02-01
We use the work done on and the heat removed from a system to maintain it in a nonequilibrium steady state for a thermodynamic-like description of such a system as well as of its fluctuations. Based on an extended Onsager-Machlup theory for nonequilibrium steady states we indicate two ambiguities, not present in an equilibrium state, in defining such work and heat: one due to a non-uniqueness of time-reversal procedures and another due to multiple possibilities to separate heat into work and an energy difference in nonequilibrium steady states. As a consequence, for such systems, the work and heat satisfy multiple versions of the first and second laws of thermodynamics as well as of their fluctuation theorems. Unique laws and relations appear only to be obtainable for concretely defined systems, using physical arguments to choose the relevant physical quantities. This is illustrated on a number of systems, including a Brownian particle in an electric field, a driven torsion pendulum, electric circuits and an energy transfer driven by a temperature difference.
Extending Molecular Theory to Steady-State Diffusing Systems
FRINK,LAURA J. D.; SALINGER,ANDREW G.; THOMPSON,AIDAN P.
1999-10-22
Predicting the properties of nonequilibrium systems from molecular simulations is a growing area of interest. One important class of problems involves steady state diffusion. To study these cases, a grand canonical molecular dynamics approach has been developed by Heffelfinger and van Swol [J. Chem. Phys., 101, 5274 (1994)]. With this method, the flux of particles, the chemical potential gradients, and density gradients can all be measured in the simulation. In this paper, we present a complementary approach that couples a nonlocal density functional theory (DFT) with a transport equation describing steady-state flux of the particles. We compare transport-DFT predictions to GCMD results for a variety of ideal (color diffusion), and nonideal (uphill diffusion and convective transport) systems. In all cases excellent agreement between transport-DFT and GCMD calculations is obtained with diffusion coefficients that are invariant with respect to density and external fields.
Optimal Control of Transitions between Nonequilibrium Steady States
Zulkowski, Patrick R.; Sivak, David A.; DeWeese, Michael R.
2013-01-01
Biological systems fundamentally exist out of equilibrium in order to preserve organized structures and processes. Many changing cellular conditions can be represented as transitions between nonequilibrium steady states, and organisms have an interest in optimizing such transitions. Using the Hatano-Sasa Y-value, we extend a recently developed geometrical framework for determining optimal protocols so that it can be applied to systems driven from nonequilibrium steady states. We calculate and numerically verify optimal protocols for a colloidal particle dragged through solution by a translating optical trap with two controllable parameters. We offer experimental predictions, specifically that optimal protocols are significantly less costly than naive ones. Optimal protocols similar to these may ultimately point to design principles for biological energy transduction systems and guide the design of artificial molecular machines. PMID:24386112
Hydrodynamics of stratified epithelium: Steady state and linearized dynamics
NASA Astrophysics Data System (ADS)
Yeh, Wei-Ting; Chen, Hsuan-Yi
2016-05-01
A theoretical model for stratified epithelium is presented. The viscoelastic properties of the tissue are assumed to be dependent on the spatial distribution of proliferative and differentiated cells. Based on this assumption, a hydrodynamic description of tissue dynamics at the long-wavelength, long-time limit is developed, and the analysis reveals important insights into the dynamics of an epithelium close to its steady state. When the proliferative cells occupy a thin region close to the basal membrane, the relaxation rate towards the steady state is enhanced by cell division and cell apoptosis. On the other hand, when the region where proliferative cells reside becomes sufficiently thick, a flow induced by cell apoptosis close to the apical surface enhances small perturbations. This destabilizing mechanism is general for continuous self-renewal multilayered tissues; it could be related to the origin of certain tissue morphology, tumor growth, and the development pattern.
Nonequilibrium Steady States of a Stochastic Model System.
NASA Astrophysics Data System (ADS)
Zhang, Qiwei
We study the nonequilibrium steady state of a stochastic lattice gas model, originally proposed by Katz, Lebowitz and Spohn (Phys. Rev. B 28: 1655 (1983)). Firstly, we solve the model on some small lattices exactly in order to see the general dependence of the steady state upon different parameters of the model. Nextly, we derive some analytical results for infinite lattice systems by taking some suitable limits. We then present some renormalization group results for the continuum version of the model via field theoretical techniques, the supersymmetry of the critical dynamics in zero field is also explored. Finally, we report some very recent 3-D Monte Carlo simulation results, which have been obtained by applying Multi-Spin-Coding techniques on a CDC vector supercomputer - Cyber 205 at John von Neumann Center.
Turnover of messenger RNA: Polysome statistics beyond the steady state
NASA Astrophysics Data System (ADS)
Valleriani, A.; Ignatova, Z.; Nagar, A.; Lipowsky, R.
2010-03-01
The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studied theoretically using a stochastic model that is motivated by recent experimental results. Random mRNA degradation affects the statistics of polysomes, i.e., the statistics of the number of ribosomes per mRNA as extracted from cells. Since ribosome loading of newly created mRNA chains requires some time to reach steady state, a fraction of the extracted mRNA/ribosome complexes does not represent steady state conditions. As a consequence, the mean ribosome density obtained from the extracted complexes is found to be inversely proportional to the mRNA length. On the other hand, the ribosome density profile shows an exponential decrease along the mRNA for prokaryotes and becomes uniform in eukaryotic cells.
Mimicking Nonequilibrium Steady States with Time-Periodic Driving
NASA Astrophysics Data System (ADS)
Raz, O.; Subaşı, Y.; Jarzynski, C.
2016-04-01
Under static conditions, a system satisfying detailed balance generically relaxes to an equilibrium state in which there are no currents. To generate persistent currents, either detailed balance must be broken or the system must be driven in a time-dependent manner. A stationary system that violates detailed balance evolves to a nonequilibrium steady state (NESS) characterized by fixed currents. Conversely, a system that satisfies instantaneous detailed balance but is driven by the time-periodic variation of external parameters—also known as a stochastic pump (SP)—reaches a periodic state with nonvanishing currents. In both cases, these currents are maintained at the cost of entropy production. Are these two paradigmatic scenarios effectively equivalent? For discrete-state systems, we establish a mapping between nonequilibrium stationary states and stochastic pumps. Given a NESS characterized by a particular set of stationary probabilities, currents, and entropy production rates, we show how to construct a SP with exactly the same (time-averaged) values. The mapping works in the opposite direction as well. These results establish a proof of principle: They show that stochastic pumps are able to mimic the behavior of nonequilibrium steady states, and vice versa, within the theoretical framework of discrete-state stochastic thermodynamics. Nonequilibrium steady states and stochastic pumps are often used to model, respectively, biomolecular motors driven by chemical reactions and artificial molecular machines steered by the variation of external, macroscopic parameters. Our results loosely suggest that anything a biomolecular machine can do, an artificial molecular machine can do equally well. We illustrate this principle by showing that kinetic proofreading, a NESS mechanism that explains the low error rates in biochemical reactions, can be effectively mimicked by a constrained periodic driving.
Harmonic coupling of steady-state visual evoked potentials.
Krusienski, Dean J; Allison, Brendan Z
2008-01-01
Steady-state visual evoked potentials (SSVEPs) are oscillating components of the electroencephalogram (EEG) that are detected over the occipital areas, having frequencies corresponding to visual stimulus frequencies. SSVEPs have been demonstrated to be reliable control signals for operating a brain-computer interface (BCI). This study uses offline analyses to investigate the characteristics of SSVEP harmonic amplitude and phase coupling and the impact of using this information to construct a matched filter for continuously tracking the signal.
The approach to steady state using homogeneous and Cartesian coordinates.
Gochberg, D F; Ding, Z
2013-01-01
Repeating an arbitrary sequence of RF pulses and magnetic field gradients will eventually lead to a steady-state condition in any magnetic resonance system. While numerical methods can quantify this trajectory, analytic analysis provides significantly more insight and a means for faster calculation. Recently, an analytic analysis using homogeneous coordinates was published. The current work further develops this line of thought and compares the relative merits of using a homogeneous or a Cartesian coordinate system.
Intense steady state neutron source. The CNR reactor
Difilippo, F.C.; Moon, R.M.; Gambill, W.R.; Moon, R.M.; Primm, R.T. III; West, C.D.
1986-01-01
The Center for Neutron Research (CNR) has been proposed in response to the needs - neutron flux, spectrum, and experimental facilities - that have been identified through workshops, studies, and discussions by the neutron-scattering, isotope, and materials irradiation research communities. The CNR is a major new experimental facility consisting of a reactor-based steady state neutron source of unprecedented flux, together with extensive facilities and instruments for neutron scattering, isotope production, materials irradiation, and other areas of research.
MUTATION RATES OF BACTERIA IN STEADY STATE POPULATIONS
Fox, Maurice S.
1955-01-01
The breeder and the chemostat have been used to measure mutation rates for two mutations under a variety of steady state growth conditions. These rates have been found to be higher in complex medium than in minimal (F) medium. The effects of changes in nutritional conditions on these high rates have been described. In addition, the mutation rates at short generation times, in complex medium, have been shown to decrease with increasing generation time. PMID:13271726
Steady state equivalence among autocatalytic peroxidase-oxidase reactions.
Méndez-González, José; Femat, Ricardo
2016-12-14
Peroxidase-oxidase is an enzymatic reaction that can exhibit dynamical scenarios such as bistability, sustained oscillations, and Shilnikov chaos. In this work, we apply the chemical reaction network theory approach to find kinetic constants such that the associated mass action kinetics ordinary differential equations induced by three four dimensional structurally different enzymatic reaction systems can support the same steady states for several chemical species despite differences in their chemical nature.
Steady state equivalence among autocatalytic peroxidase-oxidase reactions
NASA Astrophysics Data System (ADS)
Méndez-González, José; Femat, Ricardo
2016-12-01
Peroxidase-oxidase is an enzymatic reaction that can exhibit dynamical scenarios such as bistability, sustained oscillations, and Shilnikov chaos. In this work, we apply the chemical reaction network theory approach to find kinetic constants such that the associated mass action kinetics ordinary differential equations induced by three four dimensional structurally different enzymatic reaction systems can support the same steady states for several chemical species despite differences in their chemical nature.
A correspondence principle for steady-state wave problems
NASA Technical Reports Server (NTRS)
Schmerr, L. W.
1976-01-01
A correspondence principle was developed for treating the steady state propagation of waves from sources moving along a plane surface or interface. This new principle allows one to obtain, in a unified manner, explicit solutions for any source velocity. To illustrate the correspondence principle in a particular case, the problem of a load moving at an arbitrary constant velocity along the surface of an elastic half-space is considered.
Multiple Color Stimulus Induced Steady State Visual Evoked Potentials
2007-11-02
MULTIPLE COLOR STIMULUS INDUCED STEADY STATE VISUAL EVOKED POTENTIALS M. Cheng, X. Gao, S. Gao, D. Xu Institute of Biomedical Engineering...characteristics of high SNR and effectiveness in short-term identification of evoked responses. In most of the SSVEP experiments, single high...frequency stimuli are used. To characterize the complex rhythms in SSVEP, a new multiple color stimulus pattern is proposed in this paper. FFT and
Multiple steady states for characteristic initial value problems
NASA Technical Reports Server (NTRS)
Salas, M. D.; Abarbanel, S.; Gottlieb, D.
1984-01-01
The time dependent, isentropic, quasi-one-dimensional equations of gas dynamics and other model equations are considered under the constraint of characteristic boundary conditions. Analysis of the time evolution shows how different initial data may lead to different steady states and how seemingly anamolous behavior of the solution may be resolved. Numerical experimentation using time consistent explicit algorithms verifies the conclusions of the analysis. The use of implicit schemes with very large time steps leads to erroneous results.
Transition of unsteady flows of evaporation to steady state
NASA Astrophysics Data System (ADS)
d'Almeida, Amah
2008-07-01
We investigate the half-space problem of evaporation and condensation in the scope of discrete kinetic theory. Exact solutions are found to the boundary value problem and the initial boundary value problems of the flow in the half space for a discrete velocity model. The results are used to analyze the transition of the unsteady solutions towards steady states. To cite this article: A. d'Almeida, C. R. Mecanique 336 (2008).
Steady-state superradiance with alkaline-earth-metal atoms
Meiser, D.; Holland, M. J.
2010-03-15
Alkaline-earth-metal-like atoms with ultranarrow transitions open the door to a new regime of cavity quantum electrodynamics. That regime is characterized by a critical photon number that is many orders of magnitude smaller than what can be achieved in conventional systems. We show that it is possible to achieve superradiance in steady state with such systems. We discuss the basic underlying mechanisms as well as the key experimental requirements.
Steady state magnetic field configurations for the earth's magnetotail
NASA Technical Reports Server (NTRS)
Hau, L.-N.; Wolf, R. A.; Voigt, G.-H.; Wu, C. C.
1989-01-01
A two-dimensional, force-balance magnetic field model is presented. The theoretical existence of a steady state magnetic field configuration that is force-balanced and consistent with slow, lossless, adiabatic, earthward convection within the limit of the ideal MHD is demonstrated. A numerical solution is obtained for a two-dimensional magnetosphere with a rectangular magnetopause and nonflaring tail. The results are consistent with the convection time sequences reported by Erickson (1985).
Adaptive control of unknown unstable steady states of dynamical systems.
Pyragas, K; Pyragas, V; Kiss, I Z; Hudson, J L
2004-08-01
A simple adaptive controller based on a low-pass filter to stabilize unstable steady states of dynamical systems is considered. The controller is reference-free; it does not require knowledge of the location of the fixed point in the phase space. A topological limitation similar to that of the delayed feedback controller is discussed. We show that the saddle-type steady states cannot be stabilized by using the conventional low-pass filter. The limitation can be overcome by using an unstable low-pass filter. The use of the controller is demonstrated for several physical models, including the pendulum driven by a constant torque, the Lorenz system, and an electrochemical oscillator. Linear and nonlinear analyses of the models are performed and the problem of the basins of attraction of the stabilized steady states is discussed. The robustness of the controller is demonstrated in experiments and numerical simulations with an electrochemical oscillator, the dissolution of nickel in sulfuric acid; a comparison of the effect of using direct and indirect variables in the control is made. With the use of the controller, all unstable phase-space objects are successfully reconstructed experimentally.
Cavitation modeling for steady-state CFD simulations
NASA Astrophysics Data System (ADS)
Hanimann, L.; Mangani, L.; Casartelli, E.; Widmer, M.
2016-11-01
Cavitation in hydraulic turbomachines is an important phenomenon to be considered for performance predictions. Correct analysis of the cavitation onset and its effect on the flow field while diminishing the pressure level need therefore to be investigated. Even if cavitation often appears as an unsteady phenomenon, the capability to compute it in a steady state formulation for the design and assessment phase in the product development process is very useful for the engineer. In the present paper the development and corresponding application of a steady state CFD solver is presented, based on the open source toolbox OpenFOAM®. In the first part a review of different cavitation models is presented. Adopting the mixture-type cavitation approach, various models are investigated and developed in a steady state CFD RANS solver. Particular attention is given to the coupling between cavitation and turbulence models as well as on the underlying numerical procedure, especially the integration in the pressure- correction step of pressure-based solvers, which plays an important role in the stability of the procedure. The performance of the proposed model is initially assessed on simple cases available in the open literature. In a second step results for different applications are presented, ranging from airfoils to pumps.
Steady state statistical correlations predict bistability in reaction motifs.
Chakravarty, Suchana; Barik, Debashis
2017-03-01
Various cellular decision making processes are regulated by bistable switches that take graded input signals and convert them to binary all-or-none responses. Traditionally, a bistable switch generated by a positive feedback loop is characterized either by a hysteretic signal response curve with two distinct signaling thresholds or by characterizing the bimodality of the response distribution in the bistable region. To identify the intrinsic bistability of a feedback regulated network, here we propose that bistability can be determined by correlating higher order moments and cumulants (≥2) of the joint steady state distributions of two components connected in a positive feedback loop. We performed stochastic simulations of four feedback regulated models with intrinsic bistability and we show that for a bistable switch with variation of the signal dose, the steady state variance vs. covariance adopts a signatory cusp-shaped curve. Further, we find that the (n + 1)th order cross-cumulant vs. nth order cross-cumulant adopts a closed loop structure for at least n = 3. We also propose that our method is capable of identifying systems without intrinsic bistability even though the system may show bimodality in the marginal response distribution. The proposed method can be used to analyze single cell protein data measured at steady state from experiments such as flow cytometry.
Addressable nanoelectrode membrane arrays: fabrication and steady-state behavior.
Zoski, Cynthia G; Yang, Nianjun; He, Peixin; Berdondini, Luca; Koudelka-Hep, Milena
2007-02-15
An addressable nanoelectrode membrane array (ANEMA) based on a Au-filled track-etched polycarbonate membrane was fabricated. The Au-filled membrane was secured to a lithographically fabricated addressable ultramicroelectrode (UME) array patterned with 25 regularly spaced (100 microm center to center spacing), 10 microm diameter recessed Pt UMEs to create 25 microregions of 10 microm diameter nanoelectrode ensembles (NEEs) on the membrane. The steady-state voltammetric behavior of 1.0 mM Ru(NH(3))(6)Cl(3) and 1.0 mM ferrocene methanol in 0.1 M KCl on each of the micro NEEs resulted in sigmoidal-shaped voltammograms which were reproducible across the ANEMA. This reproducibility of the steady-state current was attributed to the overlapping hemispherical diffusion layers at the Au-filled nanopores of each 10 microm diameter NEE of a ANEMA. The track-etched polycarbonate membranes were filled using a gold electroless deposition procedure into the 30 nm diameter pores in the membrane. Electrical connection between the Au-filled template array and the lithographic UME platform array was achieved by potentiostatic electrodeposition of Cu from an acidic copper solution into each of the 25 recessed Pt UMEs on the UME array platform. A multiplexer unit capable of addressing 64 individual micro NEEs on an ANEMA is described. ANEMAs have advantages of high reproducibility, facile fabrication, multitime reuse of lithographically fabricated UME arrays, and purely steady-state behavior.
Steady States and Universal Conductance in a Quenched Luttinger Model
NASA Astrophysics Data System (ADS)
Langmann, Edwin; Lebowitz, Joel L.; Mastropietro, Vieri; Moosavi, Per
2017-01-01
We obtain exact analytical results for the evolution of a 1+1-dimensional Luttinger model prepared in a domain wall initial state, i.e., a state with different densities on its left and right sides. Such an initial state is modeled as the ground state of a translation invariant Luttinger Hamiltonian {H_{λ}} with short range non-local interaction and different chemical potentials to the left and right of the origin. The system evolves for time t > 0 via a Hamiltonian {H_{λ'}} which differs from {H_{λ}} by the strength of the interaction. Asymptotically in time, as {t to ∞}, after taking the thermodynamic limit, the system approaches a translation invariant steady state. This final steady state carries a current I and has an effective chemical potential difference {μ+ - μ-} between right- (+) and left- (-) moving fermions obtained from the two-point correlation function. Both I and {μ+ - μ-} depend on {λ} and {λ'}. Only for the case {λ = λ' = 0} does {μ+ - μ-} equal the difference in the initial left and right chemical potentials. Nevertheless, the Landauer conductance for the final state, {G = I/(μ+ - μ-)}, has a universal value equal to the conductance quantum {e^2/h} for the spinless case.
Steady-state mushy layers: Experiments and theory
NASA Astrophysics Data System (ADS)
Peppin, S.; Aussillous, P.; Huppert, Herbert E.; Grae Worster, M.
2006-11-01
A new facility has been developed to investigate mushy layers formed during the steady directional solidification of transparent aqueous solutions in a quasi-two-dimensional system. Experiments have been conducted on NaCl--H20 solutions by translating a Hele-Shaw cell at prescribed rates between fixed heat exchangers providing a temperature gradient of approximately 1,^0C/mm. Ice formed the primary solid phase and the dense residual fluid ponded within the mushy layer at the base of the system. Mathematical predictions of the steady-state temperature profile and mushy layer thickness as functions of freezing rate are in excellent agreement with experimental results. Experiments have also been performed on aqueous NH4Cl solutions, with the salt forming the primary solid phase, yielding buoyancy-driven convection in the mushy layer and the development of chimneys. The lifetime of the chimneys increased with decreasing freezing rate; however, no steady-state chimneys have been observed. Rather, a convecting chimney appears to deplete the surrounding solution and is eventually extinguished. At freezing rates larger than about 5.5,μm/s a uniform mushy layer develops with no chimneys. However, at rates larger than about 5,μm/s a second mode of behaviour is observed in which the mushy layer is thin and there is significant supercooling and nucleation above it. There is hysteresis between the two modes.
Steady-State and Pre-Steady-State Kinetic Analysis of Mycobacterium smegmatis Cysteine Ligase (MshC)
Fan, Fan; Luxenburger, Andreas; Painter, Gavin F.; Blanchard, John S
2008-01-01
Mycobacterium tuberculosis and many other members of the Actinomycetes family produce mycothiol, i.e., 1-D-myo-inosityl-2-(N-acetyl-L-cysteinyl)amido-2-deoxy-α-D-glucopyranoside (MSH or AcCys-GlcN-Ins), to act against oxidative and antibiotic stress. The biosynthesis of MSH is essential for cell growth, and has been proposed to proceed via a biosynthetic pathway involving four key enzymes, MshA-D. The MSH biosynthetic enzymes present potential targets for inhibitor design. With this as a long-term goal, we have carried out a kinetic and mechanistic characterization, using steady state and pre-steady state approaches, of the recombinant Mycobacterium smegmatis MshC. MshC catalyzes the ATP-dependent condensation of GlcN-Ins and cysteine to form Cys-GlcN-Ins. Initial velocity and inhibition studies show that the steady state kinetic mechanism of MshC is a Bi Uni Uni Bi Ping Pong mechanism, with ATP binding followed by cysteine binding, release of PPi, binding of GlcN-Ins, followed by the release of Cys-GlcN-Ins and AMP. The steady state kinetic parameters were determined to be: kcat equal to 3.15 s−1, and Km values of 1.8, 0.1, and 0.16 mM for ATP, cysteine, and GlcN-Ins, respectively. A stable bisubstrate analog, 5′-O-[N-(L-cysteinyl)sulfamonyl]adenosine, exhibits competitive inhibition versus ATP and non-competitive inhibition versus cysteine, with an inhibition constant of ~306 nM versus ATP. Single-turnover reactions of the first and second half reactions were determined using rapid quench techniques, giving rates of ~9.4 s−1 and ~5.2 s−1, respectively, consistent with the cysteinyl adenylate being a kinetically competent intermediate in the reaction by MshC. PMID:17848100
Steady-State Density Functional Theory for Finite Bias Conductances.
Stefanucci, G; Kurth, S
2015-12-09
In the framework of density functional theory, a formalism to describe electronic transport in the steady state is proposed which uses the density on the junction and the steady current as basic variables. We prove that, in a finite window around zero bias, there is a one-to-one map between the basic variables and both local potential on as well as bias across the junction. The resulting Kohn-Sham system features two exchange-correlation (xc) potentials, a local xc potential, and an xc contribution to the bias. For weakly coupled junctions the xc potentials exhibit steps in the density-current plane which are shown to be crucial to describe the Coulomb blockade diamonds. At small currents these steps emerge as the equilibrium xc discontinuity bifurcates. The formalism is applied to a model benzene junction, finding perfect agreement with the orthodox theory of Coulomb blockade.
Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels
Prattes, Jürgen; Duettmann, Wiebke
2016-01-01
Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state. PMID:27324763
LANSCE radiation security system (RSS)
Gallegos, F.R.
1996-12-31
The Radiation Security System (RSS) is an engineered safety system which automatically terminates transmission of accelerated ion beams in response to pre-defined abnormal conditions. It is one of the four major mechanisms used to protect people from radiation hazards induced by accelerated pulsed ion beams at the Los Alamos Neutron Science Center (LANSCE). The others are shielding, administrative policies and procedures, and qualified, trained personnel. Prompt radiation hazards at the half-mile long LANSCE accelerator exist due to average beam intensities ranging from 1 milli-amp for H{sup +} beam to 100 micro-amps for the high intensity H{sup {minus}} beam. Experimental programs are supplied with variable energy (maximum 800 MeV), pulse-width (maximum 1 msec), and pulse frequency (maximum 120 Hz) ion beams. The RSS includes personnel access control systems, beam spill monitoring systems, and beam current level limiting systems. It is a stand-alone system with redundant logic chains. A fault of the RSS will cause the insertion of fusible beam plugs in the accelerator low energy beam transport. The design philosophy, description, and operation of the RSS are described in this paper.
New Millisecond Isomer Lifetime Measurements at LANSCE
Devlin, M. Nelson, R.O.; Fotiades, N.; O'Donnell, J.M.
2014-06-15
New half-life measurements have been made of the millisecond isomers {sup 71m}Ge, {sup 114m2}I, {sup 208m}Bi, {sup 88m1}Y, {sup 88m2}Y, and {sup 75m}As populated in neutron-induced reactions. These measurements were made using the unique time structure of the LANSCE/WNR neutron source, by observing the γ-ray decays of the isomers during the time between the LANSCE proton macropulses. Two different LANSCE proton beam time structures were used. The GEANIE array of HPGe detectors was used to detect the γ-ray decays.
Stabilizing unstable steady states using multiple delay feedback control.
Ahlborn, Alexander; Parlitz, Ulrich
2004-12-31
Feedback control with different and independent delay times is introduced and shown to be an efficient method for stabilizing fixed points (equilibria) of dynamical systems. In comparison to other delay based chaos control methods multiple delay feedback control is superior for controlling steady states and works also for relatively large delay times (sometimes unavoidable in experiments due to system dead times). To demonstrate this approach for stabilizing unstable fixed points we present numerical simulations of Chua's circuit and a successful experimental application for stabilizing a chaotic frequency doubled Nd-doped yttrium aluminum garnet laser.
Nonequilibrium steady-state circulation and heat dissipation functional.
Qian, H
2001-08-01
A nonequilibrium steady-state (NESS), different from an equilibrium, is sustained by circular balance rather than detailed balance. The circular fluxes are driven by energy input and heat dissipation, accompanied by a positive entropy production. Based on a Master equation formalism for NESS, we show the circulation is intimately related to the recently studied Gallavotti-Cohen symmetry of heat dissipation functional, which in turn suggests a Boltzmann's formulalike relation between rate constants and energy in NESS. Expanding this unifying view on NESS to diffusion is discussed.
Steady-State-Preserving Simulation of Genetic Regulatory Systems
Hou, Xilin
2017-01-01
A novel family of exponential Runge-Kutta (expRK) methods are designed incorporating the stable steady-state structure of genetic regulatory systems. A natural and convenient approach to constructing new expRK methods on the base of traditional RK methods is provided. In the numerical integration of the one-gene, two-gene, and p53-mdm2 regulatory systems, the new expRK methods are shown to be more accurate than their prototype RK methods. Moreover, for nonstiff genetic regulatory systems, the expRK methods are more efficient than some traditional exponential RK integrators in the scientific literature. PMID:28203268
Thermodynamic formalism and linear response theory for nonequilibrium steady states.
Speck, Thomas
2016-08-01
We study the linear response in systems driven away from thermal equilibrium into a nonequilibrium steady state with nonvanishing entropy production rate. A simple derivation of a general response formula is presented under the condition that the generating function describes a transformation that (to lowest order) preserves normalization and thus describes a physical stochastic process. For Markov processes we explicitly construct the conjugate quantities and discuss their relation with known response formulas. Emphasis is put on the formal analogy with thermodynamic potentials and some consequences are discussed.
Steady State Vacuum Ultraviolet Exposure Facility With Automated Calibration Capability
NASA Technical Reports Server (NTRS)
Stueber, Thomas J.; Sechkar, Edward A.; Dever, Joyce A.; Banks, Bruce A.
2000-01-01
NASA Glenn Research Center at Lewis Field designed and developed a steady state vacuum ultraviolet automated (SSVUVa) facility with in situ VUV intensity calibration capability. The automated feature enables a constant accelerated VUV radiation exposure over long periods of testing without breaking vacuum. This test facility is designed to simultaneously accommodate four isolated radiation exposure tests within the SSVUVa vacuum chamber. Computer-control of the facility for long, term continuous operation also provides control and recording of thermocouple temperatures, periodic recording of VUV lamp intensity, and monitoring of vacuum facility status. This paper discusses the design and capabilities of the SSVUVa facility.
Quantum-classical correspondence in steady states of nonadiabatic systems
Fujii, Mikiya; Yamashita, Koichi
2015-12-31
We first present nonadiabatic path integral which is exact formulation of quantum dynamics in nonadiabatic systems. Then, by applying the stationary phase approximations to the nonadiabatic path integral, a semiclassical quantization condition, i.e., quantum-classical correspondence, for steady states of nonadiabatic systems is presented as a nonadiabatic trace formula. The present quantum-classical correspondence indicates that a set of primitive hopping periodic orbits, which are invariant under time evolution in the phase space of the slow degree of freedom, should be quantized. The semiclassical quantization is then applied to a simple nonadiabatic model and accurately reproduces exact quantum energy levels.
System studies for quasi-steady-state advanced physics tokamak
Reid, R.L.; Peng, Y.K.M.
1983-11-01
Parametric studies were conducted using the Fusion Engineering Design Center (FEDC) Tokamak Systems Code to investigate the impact of veriation in physics parameters and technology limits on the performance and cost of a low q/sub psi/, high beta, quasi-steady-state tokamak for the purpose of fusion engineering experimentation. The features and characteristics chosen from each study were embodied into a single Advanced Physics Tokamak design for which a self-consistent set of parameters was generated and a value of capital cost was estimated.
Steady State Creep of Zirconium at High and Intermediate Temperatures
Rosen, R.S.; Hayes, T.A.
2000-04-08
Creep of zirconium and zirconium alloys has been labeled ''anomalous.'' Researchers often report that zirconium and its alloys never reach true steady state creep and have stress exponents that continuously change with stress and temperature. Many varied interpretations have been offered explaining the creep behavior of zirconium. Some have suggested that creep is diffusion controlled, while others maintain that creep is dislocation glide controlled. Cumulative zirconium creep data will be presented based on an extensive literature review. An interpretation of results will be presented and compared to previous interpretations.
Steady-State Solution of a Flexible Wing
NASA Technical Reports Server (NTRS)
Karkehabadi, Reza; Chandra, Suresh; Krishnamurthy, Ramesh
1997-01-01
A fluid-structure interaction code, ENSAERO, has been used to compute the aerodynamic loads on a swept-tapered wing. The code has the capability of using Euler or Navier-Stokes equations. Both options have been used and compared in the present paper. In the calculation of the steady-state solution, we are interested in knowing how the flexibility of the wing influences the lift coefficients. If the results of a flexible wing are not affected by the flexibility of the wing significantly, one could consider the wing to be rigid and reduce the problem from fluid-structure interaction to a fluid problem.
Non-steady-state aerosol filtration in nanostructured fibrous media.
Przekop, Rafal; Gradoń, Leon
2011-06-28
The filtration of aerosol particles using composites of nano- and microsized fibrous structures is a promising method for the effective separation of nanoparticles from gases. A multi-scale physical system describing the flow pattern and particle deposition at a non-steady-state condition requires an advanced method of modelling. The combination of lattice Boltzmann and Brownian dynamics was used for analysis of the particle deposition pattern in a fibrous system. The dendritic structures of deposits for neutral and charged fibres and particles are present. The efficiency of deposition, deposit morphology, porosity and fractal dimension were calculated for a selected operational condition of the process.
Steady-state grain growth in UO{sub 2}
Galinari, C.M.; Lameiras, F.S.
1998-06-05
The authors have observed steady-state grain growth in sintered UO{sub 2} pellets of nuclear purity at 2,003 K under H{sub 2}. The behavior of the grain size distribution at different instants is consistent with the grain growth model proposed by one of the authors. The total number of grains was estimated using the Saltykov`s method, and the evolution is in accordance with the model proposed by Rhines and Craig. The parabolic growth law was observed for the mean intercept length with n = 0.4.
Linear modeling of steady-state behavioral dynamics.
Palya, William L; Walter, Donald; Kessel, Robert; Lucke, Robert
2002-01-01
The observed steady-state behavioral dynamics supported by unsignaled periods of reinforcement within repeating 2,000-s trials were modeled with a linear transfer function. These experiments employed improved schedule forms and analytical methods to improve the precision of the measured transfer function, compared to previous work. The refinements include both the use of multiple reinforcement periods that improve spectral coverage and averaging of independently determined transfer functions. A linear analysis was then used to predict behavior observed for three different test schedules. The fidelity of these predictions was determined. PMID:11831782
Nonequilibrium steady states in a model for prebiotic evolution
NASA Astrophysics Data System (ADS)
Wynveen, A.; Fedorov, I.; Halley, J. W.
2014-02-01
Some statistical features of steady states of a Kauffman-like model for prebiotic evolution are reported from computational studies. We postulate that the interesting "lifelike" states will be characterized by a nonequilibrium distribution of species and a time variable species self-correlation function. Selecting only such states from the population of final states produced by the model yields the probability of the appearance of such states as a function of a parameter p of the model. p is defined as the probability that a possible reaction in the the artificial chemistry actually appears in the network of chemical reactions. Small p corresponds to sparse networks utilizing a small fraction of the available reactions. We find that the probability of the appearance of such lifelike states exhibits a maximum as a function of p: at large p, most final states are in chemical equilibrium and hence are excluded by our criterion. At very small p, the sparseness of the network makes the probability of formation of any nontrivial dynamic final state low, yielding a low probability of production of lifelike states in this limit as well. We also report results on the diversity of the lifelike states (as defined here) that are produced. Repeated starts of the model evolution with different random number seeds in a given reaction network lead to final lifelike states which have a greater than random likelihood of resembling one another. Thus a form of "convergence" is observed. On the other hand, in different reaction networks with the same p, lifelike final states are statistically uncorrelated. In summary, the main results are (1) there is an optimal p or "sparseness" for production of lifelike states in our model—neither very dense nor very sparse networks are optimal—and (2) for a given p or sparseness, the resulting lifelike states can be extremely different. We discuss some possible implications for studies of the origin of life.
LANSCE beam instrumentation and the LANSCE refurbishment project
Mccrady, Rodney C; Blind, Barbara; Gilpatrick, John D; Pillai, Chandra; Power, John F; Rybarcyk, Lawrence J; Sedillo, James D; Gruchalla, Michael E
2010-01-01
The heart of the LANSCE accelerator complex consists of Cockroft-Walton-type injectors, a drift-tube linac (DTL) and a side-coupled linac (CCL). These systems are approaching 40 years of age and a project to re-establish high-power capability and to extend the lifetime is underway. Many of the present beam diagnostic systems are difficult to maintain, and the original beam position monitors don't provide any data at all. These deficiencies hamper beam tuning and trouble-shooting efforts. One thrust of the refurbishment project is to restore reliable operation of the diagnostic systems. This paper describes the present diagnostics systems and their limitations and the envisaged next-generation systems. The emphasis will be on the uses and requirements for the systems rather than the solutions and engineering aspects of the refurbishment.
Steady and transient sliding under rate-and-state friction
NASA Astrophysics Data System (ADS)
Putelat, Thibaut; Dawes, Jonathan H. P.
2015-05-01
The physics of dry friction is often modelled by assuming that static and kinetic frictional forces can be represented by a pair of coefficients usually referred to as μs and μk, respectively. In this paper we re-examine this discontinuous dichotomy and relate it quantitatively to the more general, and smooth, framework of rate-and-state friction. This is important because it enables us to link the ideas behind the widely used static and dynamic coefficients to the more complex concepts that lie behind the rate-and-state framework. Further, we introduce a generic framework for rate-and-state friction that unifies different approaches found in the literature. We consider specific dynamical models for the motion of a rigid block sliding on an inclined surface. In the Coulomb model with constant dynamic friction coefficient, sliding at constant velocity is not possible. In the rate-and-state formalism steady sliding states exist, and analysing their existence and stability enables us to show that the static friction coefficient μs should be interpreted as the local maximum at very small slip rates of the steady state rate-and-state friction law. Next, we revisit the often-cited experiments of Rabinowicz (J. Appl. Phys., 22:1373-1379, 1951). Rabinowicz further developed the idea of static and kinetic friction by proposing that the friction coefficient maintains its higher and static value μs over a persistence length before dropping to the value μk. We show that there is a natural identification of the persistence length with the distance that the block slips as measured along the stable manifold of the saddle point equilibrium in the phase space of the rate-and-state dynamics. This enables us explicitly to define μs in terms of the rate-and-state variables and hence link Rabinowicz's ideas to rate-and-state friction laws. This stable manifold naturally separates two basins of attraction in the phase space: initial conditions in the first one lead to the block
Steady-state spectroscopy of new biological probes
NASA Astrophysics Data System (ADS)
Abou-Zied, Osama K.
2007-02-01
The steady state absorption and fluorescence spectroscopy of 2-(2'-hydroxyphenyl)benzoxazole (HBO) and (2,2'-bipyridine)-3,3'-diol (BP(OH) II) were studied here free in solution and in human serum albumin (HSA) in order to test their applicability as new biological probes. HBO and BP(OH) II are known to undergo intramolecular proton transfers in the excited state. Their absorption and fluorescence spectra are sensitive to environmental change from hydrophilic to hydrophobic, thus allowing the opportunity to use them as environment-sensitive probes. The effect of water on the steady state spectra of the two molecules also shows unique features which may position them as water sensors in biological systems. For HBO in buffer, fluorescence is only due to the syn-keto tautomer, whereas in HSA the fluorescence is due to four species in equilibrium in the excited state (the syn-keto tautomer, the anti-enol tautomer, the solvated syn-enol tautomer, and the anion species of HBO). Analysis of the fluorescence spectra of HBO in HSA indicates that HBO is exposed to less water in the HBO:HSA complex. For the BP(OH) II molecule, unique absorption due to water was observed in the spectral region of 400-450 nm. This absorption decreases in the presence of HSA due to less accessibility to water as a result of binding to HSA. Fluorescence of BP(OH) II is due solely to the di-keto tautomer after double proton transfer in the excited state. The fluorescence peak of BP(OH) II shows a red-shift upon HSA recognition which is attributed to the hydrophobic environment inside the binding site of HSA. We discuss also the effect of probe-inclusion inside well-defined hydrophobic cavities of cyclodextrins.
Steady-state operation of spheromaks by inductive techniques
Janos, A.
1984-04-01
A method to maintain a steady-state spheromak configuration inductively using the S-1 Spheromak device is described. The S-1 Spheromak formation apparatus can be utilized to inject magnetic helicity continuously (C.W., not pulsed or D.C.) into the spheromak configuration after equilibrium is achieved in the linked mode of operation. Oscillation of both poloidal- and toroidal-field currents in the flux core (psi-phi Pumping), with proper phasing, injects a net time-averaged helicity into the plasma. Steady-state maintenance relies on flux conversion, which has been earlier identified. Relevant experimental data from the operation of S-1 are described. Helicity flow has been measured and the proposed injection scheme simulated. In a reasonable time practical voltages and frequencies can inject an amount of helicity comparable to that in the initial plasma. Plasma currents can be maintained or increased. This pumping technique is similar to F-THETA Pumping of a Reversed-Field-Pinch but is applied to this inverse-pinch formation.
Steady-State ALPS for Real-Valued Problems
NASA Technical Reports Server (NTRS)
Hornby, Gregory S.
2009-01-01
The two objectives of this paper are to describe a steady-state version of the Age-Layered Population Structure (ALPS) Evolutionary Algorithm (EA) and to compare it against other GAs on real-valued problems. Motivation for this work comes from our previous success in demonstrating that a generational version of ALPS greatly improves search performance on a Genetic Programming problem. In making steady-state ALPS some modifications were made to the method for calculating age and the method for moving individuals up layers. To demonstrate that ALPS works well on real-valued problems we compare it against CMA-ES and Differential Evolution (DE) on five challenging, real-valued functions and on one real-world problem. While CMA-ES and DE outperform ALPS on the two unimodal test functions, ALPS is much better on the three multimodal test problems and on the real-world problem. Further examination shows that, unlike the other GAs, ALPS maintains a genotypically diverse population throughout the entire search process. These findings strongly suggest that the ALPS paradigm is better able to avoid premature convergence then the other GAs.
New models for fast steady state magnetic reconnection
NASA Technical Reports Server (NTRS)
Priest, E. R.; Forbes, T. G.
1986-01-01
A new unified family of models for incompressible, steady-state magnetic reconnection in a finite region is presented. The models are obtained by expanding in powers of the Alfven Mach number and may be used to elucidate some of the puzzling properties of numerical experiments on reconnection which are not present in the classical models. The conditions imposed on the inflow boundary of the finite region determine which member of the family occurs. Petscheklien and Sonnerup like solutions are particular members. The Sonneruplike regime is a special case of a weak slow mode expansion in the inflow region, and it separates two classes of members with reversed currents. The Petscheklike regime is a singular case of a weak fast mode expansion, and it separates the hybrid regime from a regime of slow mode compressions. Care should be taken in deciding which type of reconnection is operating in a numerical experiment. Indeed, no experiment to date has used boundary conditions appropriate for demonstrating steady state Petschek reconnection.
Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism
Fleming, R.M.T.; Thiele, I.; Provan, G.; Nasheuer, H.P.
2010-01-01
The quantitative analysis of biochemical reactions and metabolites is at frontier of biological sciences. The recent availability of high-throughput technology data sets in biology has paved the way for new modelling approaches at various levels of complexity including the metabolome of a cell or an organism. Understanding the metabolism of a single cell and multi-cell organism will provide the knowledge for the rational design of growth conditions to produce commercially valuable reagents in biotechnology. Here, we demonstrate how equations representing steady state mass conservation, energy conservation, the second law of thermodynamics, and reversible enzyme kinetics can be formulated as a single system of linear equalities and inequalities, in addition to linear equalities on exponential variables. Even though the feasible set is non-convex, the reformulation is exact and amenable to large-scale numerical analysis, a prerequisite for computationally feasible genome scale modelling. Integrating flux, concentration and kinetic variables in a unified constraint-based formulation is aimed at increasing the quantitative predictive capacity of flux balance analysis. Incorporation of experimental and theoretical bounds on thermodynamic and kinetic variables ensures that the predicted steady state fluxes are both thermodynamically and biochemically feasible. The resulting in silico predictions are tested against fluxomic data for central metabolism in E. coli and compare favourably with in silico prediction by flux balance analysis. PMID:20230840
Zonal Flow Growth Rates: Modulational Instability vs Statistical Steady States.
NASA Astrophysics Data System (ADS)
Krommes, J. A.; Kolesnikov, R. A.
2002-11-01
The nonlinear growth rate of zonal flows has been the subject of various investigations. The calculations can be grouped into two major classes: those based on modulational instability of a fixed pump wave;(L. Chen et al., Phys. Plasmas 7), 3129 (2000); P. N. Guzdar et al., Phys. Rev. Lett. 87, 015001 (2001); C. N. Lashmore-Davies et al., Phys. Plasmas 8, 5121 (2001). and those employing statistical formalism to describe a self-consistent, energy-conserving steady state.(J. A. Krommes and C.--B. Kim, Phys. Rev. E 62), 8508 (2000), and references therein. The results from these two approaches do not necessarily agree either in their dependence on parameters like the plasma pressure β, on the threshold for instability, or even, in some cases, on the sign. The reasons for such disagreements are isolated, and it is shown to what extent the steady-state statistical approach can be reconciled with a generic modulational instability calculation. Generalizations of the statistical formalism to the multifield systems appropriate for finite β are described. Specific calculations based on model systems are used to illustrate the general arguments.
Modeling steady-state methanogenic degradation of phenols in groundwater
Bekins, Barbara A.; Godsy, E. Michael; Goerlitz, Donald F.
1993-01-01
Field and microcosm observations of methanogenic phenolic compound degradation indicate that Monod kinetics governs the substrate disappearance but overestimates the observed biomass. In this paper we present modeling results from an ongoing multidisciplinary study of methanogenic biodegradation of phenolic compounds in a sand and gravel aquifer contaminated by chemicals and wastes used in wood treatment. Field disappearance rates of four phenols match those determined in batch microcosm studies previously performed by E.M. Godsy and coworkers. The degradation process appears to be at steady-state because even after a sustained influx over several decades, the contaminants still are disappearing in transport downgradient. The existence of a steady-state degradation profile of each substrate together with a low biomass density in the aquifer indicate that the bacteria population is exhibiting no net growth. This may be due to the oligotrophic nature of the biomass population in which utilization and growth are approximately independent of concentration for most of the concentration range. Thus a constant growth rate should exist over much of the contaminated area which may in turn be balanced by an unusually high decay or maintenance rate due to hostile conditions or predation.
Steady-state wear and friction in boundary lubrication studies
NASA Technical Reports Server (NTRS)
Loomis, W. R.; Jones, W. R., Jr.
1980-01-01
A friction and wear study was made at 20 C to obtain improved reproducibility and reliability in boundary lubrication testing. Ester-base and C-ether-base fluids were used to lubricate a pure iron rider in sliding contact with a rotating M-50 steel disk in a friction and wear apparatus. Conditions included loads of 1/2 and 1 kg and sliding velocities of 3.6 to 18.2 m/min in a dry air atmosphere and stepwise time intervals from 1 to 250 min for wear measurements. The wear rate results were compared with those from previous studies where a single 25 min test period was used. Satisfactory test conditions for studying friction and wear in boundary lubrication for this apparatus were found to be 1 kg load; sliding velocities of 7.1 to 9.1 m/min (50 rpm disk speed); and use of a time stepwise test procedure. Highly reproducible steady-state wear rates and steady-state friction coefficients were determined under boundary conditions. Wear rates and coefficients of friction were constant following initially high values during run-in periods.
2005-12-01
choice of a steady state control is completely independent from the choice of a stabilizing control law. This separation is key for the methods we will...develop for steady state optimization in later sections. Combining the steady state with the stabilizing control , we can express the control law as u...for stabilizing control and optimization methods for steady state control, both unconstrained and constrained, we were able to produce promising results
40 CFR 86.1362-2010 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Torque(percent) 2 3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition. 2a Steady-state 173 A 100 2b Transition 20 Linear Transition Linear Transition. 3a Steady-state 219 B 50 3b Transition 20 B Linear Transition. 4a Steady-state 217 B 75 4b Transition 20 Linear...
Steady-state magma discharge at Etna 1971-81
NASA Technical Reports Server (NTRS)
Wadge, G.; Guest, J. E.
1981-01-01
Throughout the past decade Mount Etna has been in almost continuous activity and even during periods of repose incandescent lava has often been visible in at least one of the summit vents. Using observations by Italian, British and French volcanological teams, the volumes of lava produced by each eruption from 1971 to July 1981 have been estimated. The computed output of magma for this period approximates to a rate of 0.7 cu m/s. This is compared with the output rate estimates for Etna's historic past. The steady-state nature of the output during the past decade has implications for the interpretation of the volcano's internal plumbing and the petrology of its lavas, and the assumption that this state will be maintained allows a discussion of the timing and magnitude of future eruptions.
Transient and steady state modelling of a coupled WECS
NASA Astrophysics Data System (ADS)
Nathan, G. K.; Tan, J. K.
The paper presents a method for simulation of a wind turbine using a dc motor. The armature and field voltages of the dc motor are independently regulated to obtain torque-speed characteristics which correspond to those of a wind turbine at different wind speeds. The mass moment of inertia of the wind turbine is represented by adding a rotating mass to a parallel shaft which is positively coupled to the motor shaft. To verify the method of simulation, an American multiblade wind turbine is chosen, loaded by coupling to a centrifugal pump. Using the principle of conservation of energy and characteristics of both constituent units, two mathematical models are proposed: one for steady state operation and another for the transient state. The close comparison between the theoretical and the experimental results validates the proposed models and the method of simulation. The experimental method is described and the results of the experimental and theoretical investigation are presented.
40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles
Code of Federal Regulations, 2014 CFR
2014-07-01
...%. 1bTransition 20 Linear transition Linear transition in torque. 2aSteady-state 166 63% 25%. 2bTransition 20 Linear transition Linear transition in torque. 3aSteady-state 570 91% 75%. 3bTransition 20 Linear transition Linear transition in torque. 4aSteady-state 175 80% 50%. 1 Speed terms are defined...
40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles
Code of Federal Regulations, 2010 CFR
2010-07-01
...%. 1bTransition 20 Linear transition Linear transition in torque. 2aSteady-state 166 63% 25%. 2bTransition 20 Linear transition Linear transition in torque. 3aSteady-state 570 91% 75%. 3bTransition 20 Linear transition Linear transition in torque. 4aSteady-state 175 80% 50%. 1 Speed terms are defined...
40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles
Code of Federal Regulations, 2013 CFR
2013-07-01
...%. 1bTransition 20 Linear transition Linear transition in torque. 2aSteady-state 166 63% 25%. 2bTransition 20 Linear transition Linear transition in torque. 3aSteady-state 570 91% 75%. 3bTransition 20 Linear transition Linear transition in torque. 4aSteady-state 175 80% 50%. 1 Speed terms are defined...
Nonequilibrium steady states of ideal bosonic and fermionic quantum gases
NASA Astrophysics Data System (ADS)
Vorberg, Daniel; Wustmann, Waltraut; Schomerus, Henning; Ketzmerick, Roland; Eckardt, André
2015-12-01
We investigate nonequilibrium steady states of driven-dissipative ideal quantum gases of both bosons and fermions. We focus on systems of sharp particle number that are driven out of equilibrium either by the coupling to several heat baths of different temperature or by time-periodic driving in combination with the coupling to a heat bath. Within the framework of (Floquet-)Born-Markov theory, several analytical and numerical methods are described in detail. This includes a mean-field theory in terms of occupation numbers, an augmented mean-field theory taking into account also nontrivial two-particle correlations, and quantum-jump-type Monte Carlo simulations. For the case of the ideal Fermi gas, these methods are applied to simple lattice models and the possibility of achieving exotic states via bath engineering is pointed out. The largest part of this work is devoted to bosonic quantum gases and the phenomenon of Bose selection, a nonequilibrium generalization of Bose condensation, where multiple single-particle states are selected to acquire a large occupation [Phys. Rev. Lett. 111, 240405 (2013), 10.1103/PhysRevLett.111.240405]. In this context, among others, we provide a theory for transitions where the set of selected states changes, describe an efficient algorithm for finding the set of selected states, investigate beyond-mean-field effects, and identify the dominant mechanisms for heat transport in the Bose-selected state.
LANSCE Beam Current Limiter (XL)
Gallegos, F.R.; Hall, M.J.
1997-01-01
The Radiation Security System (RSS) at the Los Alamos Neutron Science Center (LANSCE) is an engineered safety system that provides personnel protection from prompt radiation due to accelerated proton beams. The Beam Current Limiter (XL), as an active component of the RSS, limits the maximum average current in a beamline, thus the current available for a beam spill accident. Exceeding the pre-set limit initiates action by the RSS to mitigate the hazard (insertion of beam stoppers in the low energy beam transport). The beam limiter is an electrically isolated, toroidal transformer and associated electronics. The device was designed to continuously monitor beamline currents independent of any external timing. Fail-safe operation was a prime consideration in its development. Fail-safe operation is defined as functioning as intended (due to redundant circuitry), functioning with a more sensitive fault threshold, or generating a fault condition. This report describes the design philosophy, hardware, implementation, operation, and limitations of the device.
The inductive, steady-state sustainment of stable spheromaks
NASA Astrophysics Data System (ADS)
Hossack, A. C.; Jarboe, T. R.; Morgan, K. D.; Sutherland, D. A.; Hansen, C. J.; Everson, C. J.; Penna, J. M.; Nelson, B. A.
2016-10-01
Inductive helicity injection current drive with imposed perturbations has led to the breakthrough of spheromak sustainment while maintaining stability. Sustained spheromaks show coherent, imposed plasma motion and low plasma-generated mode activity, indicating stability. Additionally, record current gain of 3.9 has been achieved with evidence of pressure confinement. The Helicity Injected Torus - Steady Inductive (HIT-SI) experiment studies efficient, steady-state current drive for magnetic confinement plasmas using a novel experimental method which is ideal for low aspect ratio, toroidal geometries and is compatible with closed flux surfaces. Analysis of surface magnetic probes indicates large n = 0 and 1 toroidal Fourier mode amplitudes and little energy in higher modes. Biorthogonal decomposition shows that almost all of the n = 1 energy is imposed by the injectors, rather than plasma-generated. Ion Doppler spectroscopy (IDS) measurements show coherent, imposed plasma motion of +/-2.5 cm in the region inside r 10 cm (a = 23 cm) and the size of the separate spheromak is consistent with that predicted by Imposed-dynamo Current Drive (IDCD). Coherent motion indicates that the spheromak is stable and a lack of plasma-generated n = 1 energy indicates that the maximum q is maintained below 1 for stability during sustainment.
Magnetocentrifugal Winds in 3D: Nonaxisymmetric Steady State
Anderson, Jeffrey M.; Li, Zhi-Yun; Krasnopolsky, Ruben; Blandford, Roger D.; /SLAC
2006-11-28
Outflows can be loaded and accelerated to high speeds along rapidly rotating, open magnetic field lines by centrifugal forces. Whether such magnetocentrifugally driven winds are stable is a longstanding theoretical problem. As a step towards addressing this problem, we perform the first large-scale 3D MHD simulations that extend to a distance {approx} 10{sup 2} times beyond the launching region, starting from steady 2D (axisymmetric) solutions. In an attempt to drive the wind unstable, we increase the mass loading on one half of the launching surface by a factor of {radical}10, and reduce it by the same factor on the other half. The evolution of the perturbed wind is followed numerically. We find no evidence for any rapidly growing instability that could disrupt the wind during the launching and initial phase of propagation, even when the magnetic field of the magnetocentrifugal wind is toroidally dominated all the way to the launching surface. The strongly perturbed wind settles into a new steady state, with a highly asymmetric mass distribution. The distribution of magnetic field strength is, in contrast, much more symmetric. We discuss possible reasons for the apparent stability, including stabilization by an axial poloidal magnetic field, which is required to bend field lines away from the vertical direction and produce a magnetocentrifugal wind in the first place.
Mimicking Nonequilibrium Steady States with Time-Periodic Driving
NASA Astrophysics Data System (ADS)
Raz, Oren; Subasi, Yigit; Jarzynski, Christopher
Under static conditions, a system satisfying detailed balance generically relaxes to an equilibrium state in which there are no currents: to generate persistent currents, either detailed balance must be broken or the system must be driven in a time-dependent manner. A stationary system that violates detailed balance evolves to a nonequilibrium steady state (NESS) characterized by fixed currents. Conversely, a system that satisfies instantaneous detailed balance but is driven by the time-periodic variation of external parameters - also known as a stochastic pump (SP) - reaches a periodic state with non-vanishing currents. In both cases, these currents are maintained at the cost of entropy production. Are these two paradigmatic scenarios effectively equivalent? For discrete-state systems we establish a mapping between NESS and SP. Given a NESS characterized by a particular set of stationary probabilities, currents and entropy production rates, we show how to construct a SP with exactly the same (time-averaged) values. The mapping works in the opposite direction as well. These results establish a proof of principle: they show that SP are able to mimic the behavior of NESS, and vice-versa, within the theoretical framework of discrete-state stochastic thermodynamics.
NASA Lewis Steady-State Heat Pipe Code Architecture
NASA Technical Reports Server (NTRS)
Mi, Ye; Tower, Leonard K.
2013-01-01
NASA Glenn Research Center (GRC) has developed the LERCHP code. The PC-based LERCHP code can be used to predict the steady-state performance of heat pipes, including the determination of operating temperature and operating limits which might be encountered under specified conditions. The code contains a vapor flow algorithm which incorporates vapor compressibility and axially varying heat input. For the liquid flow in the wick, Darcy s formula is employed. Thermal boundary conditions and geometric structures can be defined through an interactive input interface. A variety of fluid and material options as well as user defined options can be chosen for the working fluid, wick, and pipe materials. This report documents the current effort at GRC to update the LERCHP code for operating in a Microsoft Windows (Microsoft Corporation) environment. A detailed analysis of the model is presented. The programming architecture for the numerical calculations is explained and flowcharts of the key subroutines are given
Characterization of a class of stellarator steady states
Weitzner, Harold
2011-01-15
A stellarator steady state is obtained for a specific class of magnetic fields by a formal expansion in the small Larmor radius parameters of the coupled ion-electron Fokker-Planck equations. A system of relatively simple ordinary differential equations is given to determine the plasma profile functions, the number density, the temperature, and the electrostatic potential. A particular low collisionality ordering is used. The magnetic field is assumed to have stellarator symmetry of N periods in the toroidal direction and is approximated by a closed magnetic line configuration with rotational transform N/R. The magnetic field is nearly quasisymmetric. The chosen magnetic field also includes a small additional component leading to a configuration without closed lines or closed flux surfaces. The theoretical logic behind this choice of magnetic fields is also presented.
Extending the definition of entropy to nonequilibrium steady states
Ruelle, David P.
2003-01-01
We study the nonequilibrium statistical mechanics of a finite classical system subjected to nongradient forces ξ and maintained at fixed kinetic energy (Hoover–Evans isokinetic thermostat). We assume that the microscopic dynamics is sufficiently chaotic (Gallavotti–Cohen chaotic hypothesis) and that there is a natural nonequilibrium steady-state ρξ. When ξ is replaced by ξ + δξ, one can compute the change δρ of ρξ (linear response) and define an entropy change δS based on energy considerations. When ξ is varied around a loop, the total change of S need not vanish: Outside of equilibrium the entropy has curvature. However, at equilibrium (i.e., if ξ is a gradient) we show that the curvature is zero, and that the entropy S(ξ + δξ) near equilibrium is well defined to second order in δξ. PMID:12629215
Extending the definition of entropy to nonequilibrium steady states.
Ruelle, David P
2003-03-18
We study the nonequilibrium statistical mechanics of a finite classical system subjected to nongradient forces xi and maintained at fixed kinetic energy (Hoover-Evans isokinetic thermostat). We assume that the microscopic dynamics is sufficiently chaotic (Gallavotti-Cohen chaotic hypothesis) and that there is a natural nonequilibrium steady-state rho(xi). When xi is replaced by xi + deltaxi, one can compute the change deltarho of rho(xi) (linear response) and define an entropy change deltaS based on energy considerations. When xi is varied around a loop, the total change of S need not vanish: Outside of equilibrium the entropy has curvature. However, at equilibrium (i.e., if xi is a gradient) we show that the curvature is zero, and that the entropy S(xi + deltaxi) near equilibrium is well defined to second order in deltaxi.
Steady state asymmetric planetary electrical induction. [by solar wind
NASA Technical Reports Server (NTRS)
Horning, B. L.; Schubert, G.
1974-01-01
An analytic solution is presented for the steady state electric and magnetic fields induced by the motional electric field of the solar wind in the atmosphere or interior of a planet that is asymmetrically surrounded by solar wind plasma. The electrically conducting ionosphere or interior must be in direct electrical contact with the solar wind over the day side of the planet. The conducting region of the planet is modeled by a sphere or a spherical shell of arbitrarily stratified electrical conductivity. A monoconducting cylindrical cavity is assumed to extend downstream on the night side of the planet. The solar wind is assumed to be highly conducting so that the induced fields are confined to the planet and cavity. Induced currents close as sheet currents at the solar wind-cavity and solar wind-planet interfaces. Numerical evaluations of the analytic formulas are carried out for a uniformly conducting spherical model.
Steady-state mushy layers: experiments and theory
NASA Astrophysics Data System (ADS)
Peppin, S. S. L.; Aussillous, P.; Huppert, Herbert E.; Grae Worster, M.
A new facility has been developed to investigate the directional solidification of transparent aqueous solutions forming mushy layers in a quasi-two-dimensional system. Experiments have been conducted on NaCl H_{2}O solutions by translating a Hele-Shaw cell at prescribed rates between fixed heat exchangers providing a temperature gradient of approximately 1 (°) C mm(-1) . The mush liquid interface remained planar at all freezing velocities larger than 8 umum s(-1) , while steepling occurred at lower velocities. No significant undercooling of the mush liquid interface was detected at freezing velocities up to 12 umum s(-1) . Mathematical predictions of the steady-state temperature profile and mushy-layer thickness as functions of freezing rate are in excellent agreement with experimental measurements.
Entropy Production and Non-Equilibrium Steady States
NASA Astrophysics Data System (ADS)
Suzuki, Masuo
2013-01-01
The long-term issue of entropy production in transport phenomena is solved by separating the symmetry of the non-equilibrium density matrix ρ(t) in the von Neumann equation, as ρ(t) = ρs(t) + ρa(t) with the symmetric part ρs(t) and antisymmetric part ρa(t). The irreversible entropy production (dS/dt)irr is given in M. Suzuki, Physica A 390(2011)1904 by (dS/dt)irr = Tr( {H}(dρ s{(t)/dt))}/T for the Hamiltonian {H} of the relevant system. The general formulation of the extended von Neumann equation with energy supply and heat extraction is reviewed from the author's paper (M. S.,Physica A391(2012)1074). irreversibility; entropy production; transport phenomena; electric conduction; thermal conduction; linear response; Kubo formula; steady state; non-equilibrium density matrix; energy supply; symmetry-separated von Neumann equation; unboundedness.
Dust remobilization in fusion plasmas under steady state conditions
NASA Astrophysics Data System (ADS)
Tolias, P.; Ratynskaia, S.; De Angeli, M.; De Temmerman, G.; Ripamonti, D.; Riva, G.; Bykov, I.; Shalpegin, A.; Vignitchouk, L.; Brochard, F.; Bystrov, K.; Bardin, S.; Litnovsky, A.
2016-02-01
The first combined experimental and theoretical studies of dust remobilization by plasma forces are reported. The main theoretical aspects of remobilization in fusion devices under steady state conditions are analyzed. In particular, the dominant role of adhesive forces is highlighted and generic remobilization conditions—direct lift-up, sliding, rolling—are formulated. A novel experimental technique is proposed, based on controlled adhesion of dust grains on tungsten samples combined with detailed mapping of the dust deposition profile prior and post plasma exposure. Proof-of-principle experiments in the TEXTOR tokamak and the EXTRAP-T2R reversed-field pinch are presented. The versatile environment of the linear device Pilot-PSI allowed for experiments with different magnetic field topologies and varying plasma conditions that were complemented with camera observations.
Modelling of pulsed and steady-state DEMO scenarios
NASA Astrophysics Data System (ADS)
Giruzzi, G.; Artaud, J. F.; Baruzzo, M.; Bolzonella, T.; Fable, E.; Garzotti, L.; Ivanova-Stanik, I.; Kemp, R.; King, D. B.; Schneider, M.; Stankiewicz, R.; Stępniewski, W.; Vincenzi, P.; Ward, D.; Zagórski, R.
2015-07-01
Scenario modelling for the demonstration fusion reactor (DEMO) has been carried out using a variety of simulation codes. Two DEMO concepts have been analysed: a pulsed tokamak, characterized by rather conventional physics and technology assumptions (DEMO1) and a steady-state tokamak, with moderately advanced physics and technology assumptions (DEMO2). Sensitivity to impurity concentrations, radiation, and heat transport models has been investigated. For DEMO2, the impact of current driven non-inductively by neutral beams has been studied by full Monte Carlo simulations of the fast ion distribution. The results obtained are a part of a more extensive research and development (R&D) effort carried out in the EU in order to develop a viable option for a DEMO reactor, to be adopted after ITER for fusion energy research.
Steady-state plasma transition in the Venus ionosheath
NASA Technical Reports Server (NTRS)
Perez-De-tejada, H.; Intriligator, D. S.; Strangeway, R. J.
1991-01-01
The results of an extended analysis of the plasma and electric field data of the Pioneer Venus Orbiter (PVO) are presented. The persistent presence of a plasma transition embedded in the flanks of the Venus ionosheath between the bow shock and the ionopause is reported. This transition is identified by the repeated presence of characteristic bursts in the 30 kHz channel of the electric field detector of the PVO. The observed electric field signals coincide with the onset of different plasma conditions in the inner ionosheath where more rarified plasma fluxes are measured. The repeated identification of this intermediate ionosheath transition in the PVO data indicates that it is present as a steady state feature of the Venus plasma environment. The distribution of PVO orbits in which the transition is observed suggests that it is more favorably detected in the vicinity of and downstream from the terminator.
Locating CVBEM collocation points for steady state heat transfer problems
Hromadka, T.V.
1985-01-01
The Complex Variable Boundary Element Method or CVBEM provides a highly accurate means of developing numerical solutions to steady state two-dimensional heat transfer problems. The numerical approach exactly solves the Laplace equation and satisfies the boundary conditions at specified points on the boundary by means of collocation. The accuracy of the approximation depends upon the nodal point distribution specified by the numerical analyst. In order to develop subsequent, refined approximation functions, four techniques for selecting additional collocation points are presented. The techniques are compared as to the governing theory, representation of the error of approximation on the problem boundary, the computational costs, and the ease of use by the numerical analyst. ?? 1985.
A Steady-state Trio for Bretherton Equation
NASA Astrophysics Data System (ADS)
Niu, Zhao; Liu, Zeng; Cui, Jifeng
2016-12-01
To investigate if steady-state resonant solution exist for any system of weakly interacting waves in a dispersive medium, a trio is considered in the Bretherton equation based on the homotopy analysis method (HAM). Time-independent spectrum was found when all components were travelling in the same direction. Within the trio, the amplitude of longer component is larger than that of shorter one. As the difference of wave number between components in trio increases or the nonlinearity of whole system increases, the amplitudes of all components tends to increase simultaneously. These findings are helpful to enrich and deepen our understanding about resonant solutions in any dispersive medium, especially for a two-dimensional scenario.
Relativistic hydrodynamics and non-equilibrium steady states
NASA Astrophysics Data System (ADS)
Spillane, Michael; Herzog, Christopher P.
2016-10-01
We review recent interest in the relativistic Riemann problem as a method for generating a non-equilibrium steady state. In the version of the problem under consideration, the initial conditions consist of a planar interface between two halves of a system held at different temperatures in a hydrodynamic regime. The new double shock solutions are in contrast with older solutions that involve one shock and one rarefaction wave. We use numerical simulations to show that the older solutions are preferred. Briefly we discuss the effects of a conserved charge. Finally, we discuss deforming the relativistic equations with a nonlinear term and how that deformation affects the temperature and velocity in the region connecting the asymptotic fluids.
Petri nets for steady state analysis of metabolic systems.
Voss, Klaus; Heiner, Monika; Koch, Ina
2011-01-01
Computer assisted analysis and simulation of biochemical pathways can improve the understanding of the structure and the dynamics of cell processes considerably. The construction and quantitative analysis of kinetic models is often impeded by the lack of reliable data. However, as the topological structure of biochemical systems can be regarded to remain constant in time, a qualitative analysis of a pathway model was shown to be quite promising as it can render a lot of useful knowledge, e. g., about its structural invariants. The topic of this paper are pathways whose substances have reached a dynamic concentration equilibrium (steady state). It is argued that appreciated tools from biochemistry and also low-level Petri nets can yield only part of the desired results, whereas executable high-level net models lead to a number of valuable additional insights by combining symbolic analysis and simulation.
Steady state analysis of metabolic pathways using Petri nets.
Voss, Klaus; Heiner, Monika; Koch, Ina
2003-01-01
Computer assisted analysis and simulation of biochemical pathways can improve the understanding of the structure and the dynamics of cell processes considerably. The construction and quantitative analysis of kinetic models is often impeded by the lack of reliable data. However, as the topological structure of biochemical systems can be regarded to remain constant in time, a qualitative analysis of a pathway model was shown to be quite promising as it can render a lot of useful knowledge, e. g., about its structural invariants. The topic of this paper are pathways whose substances have reached a dynamic concentration equilibrium (steady state). It is argued that appreciated tools from biochemistry and also low-level Petri nets can yield only part of the desired results, whereas executable high-level net models lead to a number of valuable additional insights by combining symbolic analysis and simulation.
Steady-state thermodynamics for population growth in fluctuating environments
NASA Astrophysics Data System (ADS)
Sughiyama, Yuki; Kobayashi, Tetsuya J.
2017-01-01
We report that population dynamics in fluctuating environments is characterized by a mathematically equivalent structure to steady-state thermodynamics. By employing the structure, population growth in fluctuating environments is decomposed into housekeeping and excess parts. The housekeeping part represents the integral of the stationary growth rate for each condition during a history of the environmental change. The excess part accounts for the excess growth induced by environmental fluctuations. Focusing on the excess growth, we obtain a Clausius inequality, which gives the upper bound of the excess growth. The equality is shown to be achieved in quasistatic environmental changes. We also clarify that this bound can be evaluated by the "lineage fitness", which is an experimentally observable quantity.
A mathematical model of pan evaporation under steady state conditions
NASA Astrophysics Data System (ADS)
Lim, Wee Ho; Roderick, Michael L.; Farquhar, Graham D.
2016-09-01
In the context of changing climate, global pan evaporation records have shown a spatially-averaged trend of ∼ -2 to ∼ -3 mm a-2 over the past 30-50 years. This global phenomenon has motivated the development of the "PenPan" model (Rotstayn et al., 2006). However, the original PenPan model has yet to receive an independent experimental evaluation. Hence, we constructed an instrumented US Class A pan at Canberra Airport (Australia) and monitored it over a three-year period (2007-2010) to uncover the physics of pan evaporation under non-steady state conditions. The experimental investigations of pan evaporation enabled theoretical formulation and parameterisation of the aerodynamic function considering the wind, properties of air and (with or without) the bird guard effect. The energy balance investigation allowed for detailed formulation of the short- and long-wave radiation associated with the albedos and the emissivities of the pan water surface and the pan wall. Here, we synthesise and generalise those earlier works to develop a new model called the "PenPan-V2" model for application under steady state conditions (i.e., uses a monthly time step). Two versions (PenPan-V2C and PenPan-V2S) are tested using pan evaporation data available across the Australian continent. Both versions outperformed the original PenPan model with better representation of both the evaporation rate and the underlying physics of a US Class A pan. The results show the improved solar geometry related calculations (e.g., albedo, area) for the pan system led to a clear improvement in representing the seasonal cycle of pan evaporation. For general applications, the PenPan-V2S is simpler and suited for applications including an evaluation of long-term trends in pan evaporation.
Steady state plasma operation in RF dominated regimes on EAST
Zhang, X. J.; Zhao, Y. P.; Gong, X. Z.; Hu, C. D.; Liu, F. K.; Hu, L. Q.; Wan, B. N. Li, J. G.
2015-12-10
Significant progress has recently been made on EAST in the 2014 campaign, including the enhanced CW H&CD system over 20MW heating power (LHCD, ICRH and NBI), more than 70 diagnostics, ITER-like W-monoblock on upper divertor, two inner cryo-pumps and RMP coils, enabling EAST to investigate long pulse H mode operation with dominant electron heating and low torque to address the critical issues for ITER. H-mode plasmas were achieved by new H&CD system or 4.6GHz LHCD alone for the first time. Long pulse high performance H mode has been obtained by LHCD alone up to 28s at H{sub 98}∼1.2 or by combing of ICRH and LHCD, no or small ELM was found in RF plasmas, which is essential for steady state operation in the future Tokamak. Plasma operation in low collision regimes were implemented by new 4.6GHz LHCD with core Te∼4.5keV. The non-inductive scenarios with high performance at high bootstrap current fraction have been demonstrated in RF dominated regimes for long pulse operation. Near full non-inductive CD discharges have been achieved. In addition, effective heating and decoupling method under multi-transmitter for ICRF system were developed in this campaign, etc. EAST could be in operation with over 30MW CW heating and current drive power (LHCD ICRH NBI and ECRH), enhanced diagnostic capabilities and full actively-cooled metal wall from 2015. It will therefore allow to access new confinement regimes and to extend these regimes towards to steady state operation.
Steady state plasma operation in RF dominated regimes on EAST
NASA Astrophysics Data System (ADS)
Zhang, X. J.; Zhao, Y. P.; Gong, X. Z.; Hu, C. D.; Liu, F. K.; Hu, L. Q.; Wan, B. N.; Li, J. G.
2015-12-01
Significant progress has recently been made on EAST in the 2014 campaign, including the enhanced CW H&CD system over 20MW heating power (LHCD, ICRH and NBI), more than 70 diagnostics, ITER-like W-monoblock on upper divertor, two inner cryo-pumps and RMP coils, enabling EAST to investigate long pulse H mode operation with dominant electron heating and low torque to address the critical issues for ITER. H-mode plasmas were achieved by new H&CD system or 4.6GHz LHCD alone for the first time. Long pulse high performance H mode has been obtained by LHCD alone up to 28s at H98˜1.2 or by combing of ICRH and LHCD, no or small ELM was found in RF plasmas, which is essential for steady state operation in the future Tokamak. Plasma operation in low collision regimes were implemented by new 4.6GHz LHCD with core Te˜4.5keV. The non-inductive scenarios with high performance at high bootstrap current fraction have been demonstrated in RF dominated regimes for long pulse operation. Near full non-inductive CD discharges have been achieved. In addition, effective heating and decoupling method under multi-transmitter for ICRF system were developed in this campaign, etc. EAST could be in operation with over 30MW CW heating and current drive power (LHCD ICRH NBI and ECRH), enhanced diagnostic capabilities and full actively-cooled metal wall from 2015. It will therefore allow to access new confinement regimes and to extend these regimes towards to steady state operation.
Three-state, steady-state Ising systems: Monte Carlo and Bragg-Williams treatments
Hill, Terrell L.; Chen, Yi-Der
1981-01-01
In two earlier papers, the steady-state critical and phase-transition properties of a lattice of three-state enzyme molecules were studied by using the “closed” Bragg-Williams (BW), or mean field, approximation. The “open” BW and Monte Carlo methods are applied to the same problem in this paper by using finite lattices. The open BW treatment provides a way of locating the cut across a van der Waals type of loop encountered in a phase transition in the closed BW system. Thermodynamic-like methods cannot be used for this purpose as they can with two-state, steady-state systems. PMID:16592956
Steady state quantum discord for circularly accelerated atoms
Hu, Jiawei; Yu, Hongwei
2015-12-15
We study, in the framework of open quantum systems, the dynamics of quantum entanglement and quantum discord of two mutually independent circularly accelerated two-level atoms in interaction with a bath of fluctuating massless scalar fields in the Minkowski vacuum. We assume that the two atoms rotate synchronically with their separation perpendicular to the rotating plane. The time evolution of the quantum entanglement and quantum discord of the two-atom system is investigated. For a maximally entangled initial state, the entanglement measured by concurrence diminishes to zero within a finite time, while the quantum discord can either decrease monotonically to an asymptotic value or diminish to zero at first and then followed by a revival depending on whether the initial state is antisymmetric or symmetric. When both of the two atoms are initially excited, the generation of quantum entanglement shows a delayed feature, while quantum discord is created immediately. Remarkably, the quantum discord for such a circularly accelerated two-atom system takes a nonvanishing value in the steady state, and this is distinct from what happens in both the linear acceleration case and the case of static atoms immersed in a thermal bath.
Steady-state and dynamic network modes for perceptual expectation
Choi, Uk-Su; Sung, Yul-Wan; Ogawa, Seiji
2017-01-01
Perceptual expectation can attenuate repetition suppression, the stimulus-induced neuronal response generated by repeated stimulation, suggesting that repetition suppression is a top-down modulatory phenomenon. However, it is still unclear which high-level brain areas are involved and how they interact with low-level brain areas. Further, the temporal range over which perceptual expectation can effectively attenuate repetition suppression effects remains unclear. To elucidate the details of this top-down modulatory process, we used two short and long inter-stimulus intervals for a perceptual expectation paradigm of paired stimulation. We found that top-down modulation enhanced the response to the unexpected stimulus when repetition suppression was weak and that the effect disappeared at 1,000 ms prior to stimulus exposure. The high-level areas involved in this process included the left inferior frontal gyrus (IFG_L) and left parietal lobule (IPL_L). We also found two systems providing modulatory input to the right fusiform face area (FFA_R): one from IFG_L and the other from IPL_L. Most importantly, we identified two states of networks through which perceptual expectation modulates sensory responses: one is a dynamic state and the other is a steady state. Our results provide the first functional magnetic resonance imaging (fMRI) evidence of temporally nested networks in brain processing. PMID:28079163
Ising game: Nonequilibrium steady states of resource-allocation systems
NASA Astrophysics Data System (ADS)
Xin, C.; Yang, G.; Huang, J. P.
2017-04-01
Resource-allocation systems are ubiquitous in the human society. But how external fields affect the state of such systems remains poorly explored due to the lack of a suitable model. Because the behavior of spins pursuing energy minimization required by physical laws is similar to that of humans chasing payoff maximization studied in game theory, here we combine the Ising model with the market-directed resource-allocation game, yielding an Ising game. Based on the Ising game, we show theoretical, simulative and experimental evidences for a formula, which offers a clear expression of nonequilibrium steady states (NESSs). Interestingly, the formula also reveals a convertible relationship between the external field (exogenous factor) and resource ratio (endogenous factor), and a class of saturation as the external field exceeds certain limits. This work suggests that the Ising game could be a suitable model for studying external-field effects on resource-allocation systems, and it could provide guidance both for seeking more relations between NESSs and equilibrium states and for regulating human systems by choosing NESSs appropriately.
Steady-state and dynamic network modes for perceptual expectation.
Choi, Uk-Su; Sung, Yul-Wan; Ogawa, Seiji
2017-01-12
Perceptual expectation can attenuate repetition suppression, the stimulus-induced neuronal response generated by repeated stimulation, suggesting that repetition suppression is a top-down modulatory phenomenon. However, it is still unclear which high-level brain areas are involved and how they interact with low-level brain areas. Further, the temporal range over which perceptual expectation can effectively attenuate repetition suppression effects remains unclear. To elucidate the details of this top-down modulatory process, we used two short and long inter-stimulus intervals for a perceptual expectation paradigm of paired stimulation. We found that top-down modulation enhanced the response to the unexpected stimulus when repetition suppression was weak and that the effect disappeared at 1,000 ms prior to stimulus exposure. The high-level areas involved in this process included the left inferior frontal gyrus (IFG_L) and left parietal lobule (IPL_L). We also found two systems providing modulatory input to the right fusiform face area (FFA_R): one from IFG_L and the other from IPL_L. Most importantly, we identified two states of networks through which perceptual expectation modulates sensory responses: one is a dynamic state and the other is a steady state. Our results provide the first functional magnetic resonance imaging (fMRI) evidence of temporally nested networks in brain processing.
Critical Concavity of a Drainage Basin for Steady-State
NASA Astrophysics Data System (ADS)
Byun, Jongmin; Paik, Kyungrock
2015-04-01
Longitudinal profiles of natural streams are known to show concave forms. Saying A as drainage area, channel gradient S can be expressed as the power-law, S≈A-θ (Flint, 1974), which is one of the scale-invariant features of drainage basin. According to literature, θ of most natural streams falls into a narrow range (0.4 < θ < 0.7) (Tucker and Whipple, 2002). It leads to fundamental questions: 'Why does θ falls into such narrow range?' and 'How is this related with other power-law scaling relationships reported in natural drainage basins?' To answer above questions, we analytically derive θ for a steady-state drainage basin following Lane's equilibrium (Lane, 1955) throughout the corridor and named this specific case as the 'critical concavity'. In the derivation, sediment transport capacity is estimated by unit stream power model (Yang, 1976), yielding a power function of upstream area. Stability of channel at a local point occurs when incoming flux equals outgoing flux at the point. Therefore, given the drainage at steady-state where all channel beds are stable, the exponent of the power function should be zero. From this, we can determine the critical concavity. Considering ranges of variables associated in this derivation, critical concavity cannot be resolved as a single definite value, rather a range of critical concavity is suggested. This range well agrees with the widely reported range of θ (0.4 < θ < 0.7) in natural streams. In this theoretical study, inter-relationships between power-laws such as hydraulic geometry (Leopold and Maddock, 1953), dominant discharge-drainage area (Knighton et al., 1999), and concavity, are coupled into the power-law framework of stream power sediment transport model. This allows us to explore close relationships between their power-law exponents: their relative roles and sensitivity. Detailed analysis and implications will be presented. References Flint, J. J., 1974, Stream gradient as a function of order, magnitude
Grand canonical steady-state simulation of nucleation
NASA Astrophysics Data System (ADS)
Horsch, Martin; Vrabec, Jadran
2009-11-01
Grand canonical molecular dynamics (GCMD) is applied to the nucleation process in a metastable phase near the spinodal, where nucleation occurs almost instantaneously and is limited to a very short time interval. With a variant of Maxwell's demon, proposed by McDonald [Am. J. Phys. 31, 31 (1963)], all nuclei exceeding a specified size are removed. In such a steady-state simulation, the nucleation process is sampled over an arbitrary time span and all properties of the metastable state, including the nucleation rate, can be obtained with an increased precision. As an example, a series of GCMD simulations with McDonald's demon is carried out for homogeneous vapor to liquid nucleation of the truncated-shifted Lennard-Jones (tsLJ) fluid, covering the entire relevant temperature range. The results are in agreement with direct nonequilibrium MD simulation in the canonical ensemble. It is confirmed for supersaturated vapors of the tsLJ fluid that the classical nucleation theory underpredicts the nucleation rate by two orders of magnitude.
Modeling on the Steady State of Thwaites Glacier
NASA Astrophysics Data System (ADS)
Yu, H.; Rignot, E. J.; Morlighem, M.; Seroussi, H.
2013-12-01
Thwaites Glacier (TWG) is the second largest ice stream in West Antarctica in terms of ice discharge, and the broadest ice stream in Antarctica (120 km wide). Observations and theory suggest that its configuration is inherently unstable in a warming climate. Satellite observations have revealed grounding line retreat, ice thinning, ice stream broadening and in more recent years ice flow acceleration. The most important part of the glacier evolution involves its grounding line dynamics and the impact of ice-ocean interactions. In a region between the grounding line and the limit of the flexure zone, some 10 km downstream, however, the glacier is not in hydrostatic equilibrium. Proper treatment of the grounding line dynamics requires full Stokes solution. Here, we model the grounding line of TWG in 2D, full Stokes, with the goal to examine whether the glacier is in a steady state configuration or not. The model treats ice sheet and ice shelf as two fluids coupled through the ice mass flux (Nowicki, 2008). Water stress is used as a constraint on the ice shelf instead of hydrostatic equilibrium. We use radar interferometry (InSAR) measurements of ice velocity and grounding line position through time, Bedmap2 and IceBridge thickness, and surface mass balance from RACMO to constrain the model. The results are used to conclude on the state of dynamic balance of the glacier. This work is funded by NASA Cryospheric Science Program.
Dynamic steady state of periodically driven quantum systems
NASA Astrophysics Data System (ADS)
Yudin, V. I.; Taichenachev, A. V.; Basalaev, M. Yu.
2016-01-01
Using the density matrix formalism, we prove the existence of the periodic steady state for an arbitrary periodically driven system described by linear dynamic equations. This state has the same period as the modulated external influence, and it is realized as an asymptotic solution (t →+∞ ) due to relaxation processes. The presented derivation simultaneously contains a simple and effective computational algorithm (without using either the Floquet or Fourier formalisms), which automatically guarantees a full account of all frequency components. As a particular example, for three-level Λ system we calculate the line shape and field-induced shift of the dark resonance formed by the field with a periodically modulated phase. Also we have analytically solved a basic theoretical problem of the direct frequency comb spectroscopy, when the two-level system is driven by the periodic sequence of rectangular pulses. In this case, the radical dependence of the spectroscopy line shape on pulse area is found. Moreover, the existence of quasiforbidden spectroscopic zones, in which the Ramsey fringes are significantly reduced, is predicted. Our results have a wide area of applications in laser physics, spectroscopy, atomic clocks, and magnetometry. Also they can be useful for any area of quantum physics where periodically driven systems are considered.
Status of the LANSCE refurbishment project
Erickson, John L; Jones, Kevin W; Prince, Peter P
2010-01-01
The Los Alamos Neutron Science Center (LANSCE) accelerator is an 800-MeV proton linac that drives user facilities for isotope production, proton radiography, ultra-cold neutrons, weapons neutron research and various sciences using neutron scattering. The LANSCE Refurbishment Project (LANSCE-R) is an ambitious project to refurbish key elements of the LANSCE accelerator that are becoming obsolete or nearing end-of-life. The preliminary design phase for the project is funded and underway. The 6 year, $150M (US) project will enable future decades of reliable, high-performance operation. It will replace a substantial fraction of the radio-frequency power systems (gridded tubes and klystrons) with modern systems, completely refurbish the original accelerator control and timing systems, replace obsolete diagnostic devices, and modernize other ancillary systems. An overview of the LANSCE-R project will be presented. The project requirements will be discussed, the preliminary technical solutions presented, and the plan for successful project execution while meeting annual customer expectations for beam delivery will be reviewed.
Yongky, Andrew; Lee, Jongchan; Le, Tung; Mulukutla, Bhanu Chandra; Daoutidis, Prodromos; Hu, Wei-Shou
2015-07-01
Continuous culture for the production of biopharmaceutical proteins offers the possibility of steady state operations and thus more consistent product quality and increased productivity. Under some conditions, multiplicity of steady states has been observed in continuous cultures of mammalian cells, wherein with the same dilution rate and feed nutrient composition, steady states with very different cell and product concentrations may be reached. At those different steady states, cells may exhibit a high glycolysis flux with high lactate production and low cell concentration, or a low glycolysis flux with low lactate and high cell concentration. These different steady states, with different cell concentration, also have different productivity. Developing a mechanistic understanding of the occurrence of steady state multiplicity and devising a strategy to steer the culture toward the desired steady state is critical. We establish a multi-scale kinetic model that integrates a mechanistic intracellular metabolic model and cell growth model in a continuous bioreactor. We show that steady state multiplicity exists in a range of dilution rate in continuous culture as a result of the bistable behavior in glycolysis. The insights from the model were used to devise strategies to guide the culture to the desired steady state in the multiple steady state region. The model provides a guideline principle in the design of continuous culture processes of mammalian cells.
The Budyko functions under non-steady-state conditions
NASA Astrophysics Data System (ADS)
Moussa, Roger; Lhomme, Jean-Paul
2016-12-01
The Budyko functions relate the evaporation ratio E / P (E is evaporation and P precipitation) to the aridity index Φ = Ep / P (Ep is potential evaporation) and are valid on long timescales under steady-state conditions. A new physically based formulation (noted as Moussa-Lhomme, ML) is proposed to extend the Budyko framework under non-steady-state conditions taking into account the change in terrestrial water storage ΔS. The variation in storage amount ΔS is taken as negative when withdrawn from the area at stake and used for evaporation and positive otherwise, when removed from the precipitation and stored in the area. The ML formulation introduces a dimensionless parameter HE = -ΔS / Ep and can be applied with any Budyko function. It represents a generic framework, easy to use at various time steps (year, season or month), with the only data required being Ep, P and ΔS. For the particular case where the Fu-Zhang equation is used, the ML formulation with ΔS ≤ 0 is similar to the analytical solution of Greve et al. (2016) in the standard Budyko space (Ep / P, E / P), a simple relationship existing between their respective parameters. The ML formulation is extended to the space [Ep / (P - ΔS), E / (P - ΔS)] and compared to the formulations of Chen et al. (2013) and Du et al. (2016). The ML (or Greve et al., 2016) feasible domain has a similar upper limit to that of Chen et al. (2013) and Du et al. (2016), but its lower boundary is different. Moreover, the domain of variation of Ep / (P - ΔS) differs: for ΔS ≤ 0, it is bounded by an upper limit 1 / HE in the ML formulation, while it is only bounded by a lower limit in Chen et al.'s (2013) and Du et al.'s (2016) formulations. The ML formulation can also be conducted using the dimensionless parameter HP = -ΔS / P instead of HE, which yields another form of the equations.
Mantle Sulfur Cycle: A Case for Non-Steady State ?
NASA Astrophysics Data System (ADS)
Cartigny, Pierre; Labidi, Jabrane
2016-04-01
Data published over the last 5 years show that the early inference that mantle is isotopically homogeneous is no more valid. Instead, new generation data on lavas range over a significant 34S/32S variability of up to 5‰ with δ 34S values often correlated to Sr- and Nd-isotope compositions. This new set of data also reveals the Earth's mantle to have a sub-chondritic 34S/32S ratio, by about ˜ 1‰. We will present at the conference our published and unpublished data on samples characterizing the different mantle components (i.e. EM1, EM2, HIMU and LOMU). All illustrate 34S-enrichments compared to MORB with Δ 33S and Δ 36S values indistinguishable from CDT or chondrites at the 0.03‰ level. These data are consistent with the recycling of subducted components carrying sulfur with Δ 33S and Δ 36S-values close to zero. Archean rocks commonly display Δ 33S and Δ 36S values deviating from zero by 1 to 10 ‰. The lack of variations for Δ 33S and Δ 36S values in present day lava argue against the sampling of any subducted protolith of Archean age in their mantle source. Instead, our data are consistent with the occurrence of Proterozoic subducted sulfur in the source of the EM1, EM2, LOMU and HIMU endmember at the St-Helena island. This is in agreement with the age of those components early derived through the use of the Pb isotope systematic. Currently, the negative δ 34S-values of the depleted mantle seem to be associated with mostly positive values of enriched components. This would be inconsistent with the concept a steady state of sulfur. Assuming that the overall observations of recycled sulfur are not biased, the origin of such a non-steady state remains unclear. It could be related to the relatively compatible behavior of sulfur during partial melting, as the residue of present-day melting can be shown to always contain significant amounts of sulfide (50{%} of what is observed in a fertile source). This typical behavior likely prevents an efficient
Neutron Imaging Developments at LANSCE
NASA Astrophysics Data System (ADS)
Nelson, Ron; Hunter, James; Schirato, Richard; Vogel, Sven; Swift, Alicia; Ickes, Tim; Ward, Bill; Losko, Adrian; Tremsin, Anton
2015-10-01
Neutron imaging is complementary to x-ray imaging because of its sensitivity to light elements and greater penetration of high-Z materials. Energy-resolved neutron imaging can provide contrast enhancements for elements and isotopes due to the variations with energy in scattering cross sections due to nuclear resonances. These cross section differences exist due to compound nuclear resonances that are characteristic of each element and isotope, as well as broader resonances at higher energies. In addition, multi-probe imaging, such as combined photon and neutron imaging, is a powerful tool for discerning properties and features in materials that cannot be observed with a single probe. Recently, we have demonstrated neutron imaging, both radiography and computed tomography, using the moderated (Lujan Center) and high-energy (WNR facility) neutron sources at LANSCE. Flat panel x-ray detectors with suitable scintillator-converter screens provide good sensitivity for both low and high neutron energies. Micro-Channel-Plate detectors and iCCD scintillator camera systems that provide the fast time gating needed for energy-resolved imaging have been demonstrated as well. Examples of recent work will be shown including fluid flow in plants and imaging through dense thick objects. This work is funded by the US Department of Energy, National Nuclear Security Administration, and performed by Los Alamos National Security LLC under Contract DE-AC52-06NA25396.
LANSCE personnel access control system
Sturrock, J.C.; Gallegos, F.R.; Hall, M.J.
1997-01-01
The Radiation Security System (RSS) at the Los Alamos Neutron Science Center (LANSCE) provides personnel protection from prompt radiation due to accelerated beam. The Personnel Access Control System (PACS) is a component of the RSS that is designed to prevent personnel access to areas where prompt radiation is a hazard. PACS was designed to replace several older personnel safety systems (PSS) with a single modem unified design. Lessons learned from the operation over the last 20 years were incorporated into a redundant sensor, single-point failure safe, fault tolerant, and tamper-resistant system that prevents access to the beam areas by controlling the access keys and beam stoppers. PACS uses a layered philosophy to the physical and electronic design. The most critical assemblies are battery backed up, relay logic circuits; less critical devices use Programmable Logic Controllers (PLCs) for timing functions and communications. Outside reviewers have reviewed the operational safety of the design. The design philosophy, lessons learned, hardware design, software design, operation, and limitations of the device are described.
Steady state solutions to dynamically loaded periodic structures
NASA Technical Reports Server (NTRS)
Kalinowski, A. J.
1980-01-01
The general problem of solving for the steady state (time domain) dynamic response (i.e., NASTRAN rigid format-8) of a general elastic periodic structure subject to a phase difference loading of the type encountered in traveling wave propagation problems was studied. Two types of structural configurations were considered; in the first type, the structure has a repeating pattern over a span that is long enough to be considered, for all practical purposes, as infinite; in the second type, the structure has structural rotational symmetry in the circumferential direction. The theory and a corresponding set of DMAP instructions which permits the NASTRAN user to automatically alter the rigid format-8 sequence to solve the intended class of problems are presented. Final results are recovered as with any ordinary rigid format-8 solution, except that the results are only printed for the typical periodic segment of the structure. A simple demonstration problem having a known exact solution is used to illustrate the implementation of the procedure.
Visual steady state in relation to age and cognitive function.
Horwitz, Anna; Dyhr Thomsen, Mia; Wiegand, Iris; Horwitz, Henrik; Klemp, Marc; Nikolic, Miki; Rask, Lene; Lauritzen, Martin; Benedek, Krisztina
2017-01-01
Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.
Visual steady state in relation to age and cognitive function
Dyhr Thomsen, Mia; Wiegand, Iris; Horwitz, Henrik; Klemp, Marc; Nikolic, Miki; Rask, Lene; Lauritzen, Martin; Benedek, Krisztina
2017-01-01
Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age. PMID:28245274
Attentional Modulation of Auditory Steady-State Responses
Mahajan, Yatin; Davis, Chris; Kim, Jeesun
2014-01-01
Auditory selective attention enables task-relevant auditory events to be enhanced and irrelevant ones suppressed. In the present study we used a frequency tagging paradigm to investigate the effects of attention on auditory steady state responses (ASSR). The ASSR was elicited by simultaneously presenting two different streams of white noise, amplitude modulated at either 16 and 23.5 Hz or 32.5 and 40 Hz. The two different frequencies were presented to each ear and participants were instructed to selectively attend to one ear or the other (confirmed by behavioral evidence). The results revealed that modulation of ASSR by selective attention depended on the modulation frequencies used and whether the activation was contralateral or ipsilateral. Attention enhanced the ASSR for contralateral activation from either ear for 16 Hz and suppressed the ASSR for ipsilateral activation for 16 Hz and 23.5 Hz. For modulation frequencies of 32.5 or 40 Hz attention did not affect the ASSR. We propose that the pattern of enhancement and inhibition may be due to binaural suppressive effects on ipsilateral stimulation and the dominance of contralateral hemisphere during dichotic listening. In addition to the influence of cortical processing asymmetries, these results may also reflect a bias towards inhibitory ipsilateral and excitatory contralateral activation present at the level of inferior colliculus. That the effect of attention was clearest for the lower modulation frequencies suggests that such effects are likely mediated by cortical brain structures or by those in close proximity to cortex. PMID:25334021
Maximally reliable spatial filtering of steady state visual evoked potentials.
Dmochowski, Jacek P; Greaves, Alex S; Norcia, Anthony M
2015-04-01
Due to their high signal-to-noise ratio (SNR) and robustness to artifacts, steady state visual evoked potentials (SSVEPs) are a popular technique for studying neural processing in the human visual system. SSVEPs are conventionally analyzed at individual electrodes or linear combinations of electrodes which maximize some variant of the SNR. Here we exploit the fundamental assumption of evoked responses--reproducibility across trials--to develop a technique that extracts a small number of high SNR, maximally reliable SSVEP components. This novel spatial filtering method operates on an array of Fourier coefficients and projects the data into a low-dimensional space in which the trial-to-trial spectral covariance is maximized. When applied to two sample data sets, the resulting technique recovers physiologically plausible components (i.e., the recovered topographies match the lead fields of the underlying sources) while drastically reducing the dimensionality of the data (i.e., more than 90% of the trial-to-trial reliability is captured in the first four components). Moreover, the proposed technique achieves a higher SNR than that of the single-best electrode or the Principal Components. We provide a freely-available MATLAB implementation of the proposed technique, herein termed "Reliable Components Analysis".
Quasi-steady state aerodynamics of the cheetah tail.
Patel, Amir; Boje, Edward; Fisher, Callen; Louis, Leeann; Lane, Emily
2016-08-15
During high-speed pursuit of prey, the cheetah (Acinonyx jubatus) has been observed to swing its tail while manoeuvring (e.g. turning or braking) but the effect of these complex motions is not well understood. This study demonstrates the potential of the cheetah's long, furry tail to impart torques and forces on the body as a result of aerodynamic effects, in addition to the well-known inertial effects. The first-order aerodynamic forces on the tail are quantified through wind tunnel testing and it is observed that the fur nearly doubles the effective frontal area of the tail without much mass penalty. Simple dynamic models provide insight into manoeuvrability via simulation of pitch, roll and yaw tail motion primitives. The inertial and quasi-steady state aerodynamic effects of tail actuation are quantified and compared by calculating the angular impulse imparted onto the cheetah's body and its shown aerodynamic effects contribute to the tail's angular impulse, especially at the highest forward velocities.
Quasi-steady state aerodynamics of the cheetah tail
Boje, Edward; Fisher, Callen; Louis, Leeann; Lane, Emily
2016-01-01
ABSTRACT During high-speed pursuit of prey, the cheetah (Acinonyx jubatus) has been observed to swing its tail while manoeuvring (e.g. turning or braking) but the effect of these complex motions is not well understood. This study demonstrates the potential of the cheetah's long, furry tail to impart torques and forces on the body as a result of aerodynamic effects, in addition to the well-known inertial effects. The first-order aerodynamic forces on the tail are quantified through wind tunnel testing and it is observed that the fur nearly doubles the effective frontal area of the tail without much mass penalty. Simple dynamic models provide insight into manoeuvrability via simulation of pitch, roll and yaw tail motion primitives. The inertial and quasi-steady state aerodynamic effects of tail actuation are quantified and compared by calculating the angular impulse imparted onto the cheetah's body and its shown aerodynamic effects contribute to the tail's angular impulse, especially at the highest forward velocities. PMID:27412267
The Path of Carbon in Photosynthesis XX. The Steady State
DOE R&D Accomplishments Database
Calvin, M.; Massini, Peter
1952-09-01
The separation of the phenomenon of photosynthesis in green plants into a photochemical reaction and into the light-dependent reduction of carbon dioxide is discussed, The reduction of carbon dioxide and the fate of the assimilated carbon were investigated with the help of the tracer technique (exposure of the planks to the radioactive C{sup 14}O{sub 2}) and of paper chromatography. A reaction cycle is proposed in which phosphoglyceric acid is the first isolable assimilations product. Analyses of the algal extracts which had assimilated radioactive carbon dioxide in a stationary condition ('steady-state' photosynthesis) for a long time provided further information concerning the proposed cycle and permitted the approximate estimation, for a number of compounds of what fraction of each compound was taking part in the cycle. The earlier supposition that light influences the respiration cycle was confirmed. The possibility of the assistance of {alpha}-lipoic acid, or of a related substance, in this influence and in the photosynthesis cycle, is discussed.
Flavour fields in steady state: stress tensor and free energy
NASA Astrophysics Data System (ADS)
Banerjee, Avik; Kundu, Arnab; Kundu, Sandipan
2016-02-01
The dynamics of a probe brane in a given gravitational background is governed by the Dirac-Born-Infeld action. The corresponding open string metric arises naturally in studying the fluctuations on the probe. In Gauge-String duality, it is known that in the presence of a constant electric field on the worldvolume of the probe, the open string metric acquires an event horizon and therefore the fluctuation modes on the probe experience an effective temperature. In this article, we bring together various properties of such a system to a formal definition and a subsequent narration of the effective thermodynamics and the stress tensor of the corresponding flavour fields, also including a non-vanishing chemical potential. In doing so, we point out a potentially infinitely-degenerate scheme-dependence of regularizing the free energy, which nevertheless yields a universal contribution in certain cases. This universal piece appears as the coefficient of a log-divergence in free energy when a space-filling probe brane is embedded in AdS d+1-background, for d = 2, 4, and is related to conformal anomaly. For the special case of d = 2, the universal factor has a striking resemblance to the well-known heat current formula in (1 + 1)-dimensional conformal field theory in steady-state, which endows a plausible physical interpretation to it. Interestingly, we observe a vanishing conformal anomaly in d = 6.
Models of steady state cooling flows in elliptical galaxies
NASA Technical Reports Server (NTRS)
Vedder, Peter W.; Trester, Jeffrey J.; Canizares, Claude R.
1988-01-01
A comprehensive set of steady state models for spherically symmetric cooling flows in early-type galaxies is presented. It is found that a reduction of the supernova (SN) rate in ellipticals produces a decrease in the X-ray luminosity of galactic cooling flows and a steepening of the surface brightness profile. The mean X-ray temperature of the cooling flow is not affected noticeably by a change in the SN rate. The external pressure around a galaxy does not markedly change the luminosity of the gas within the galaxy but does change the mean temperature of the gas. The presence of a dark matter halo in a galaxy only changes the mean X-ray temperature slightly. The addition of a distribution of mass sinks which remove material from the general accretion flow reduces L(X) very slightly, flattens the surface brightness profile, and reduces the central surface brightness level to values close to those actually observed. A reduction in the stellar mass-loss rate only slightly reduces the X-ray luminosity of the cooling flow and flattens the surface brightness by a small amount.
Optomechanically induced transparency associated with steady-state entanglement
NASA Astrophysics Data System (ADS)
He, Yong
2015-01-01
We theoretically investigate a two-cavity optomechanical system in which a cavity (cavity a ) couples to a mechanical resonator via radiation pressure and to another cavity (cavity c ) via a common waveguide. In the excitation of a strong pump filed to cavity a , the steady-state entanglement between cavity a and c , as a quantum channel, can be generated, which provides an indirect optical pathway to excite cavity c by means of the pump filed. Quantum interference between the direct and indirect optical pathways gives rise to an optomechanically induced transparency appearing in the probe transmission of cavity c . Unlike in a typical optomechanically induced transparency effect, the electromagnetical control of the transmission is implemented by resorting to the quantum channel. Furthermore, the coupling strength of the two cavities is an important factor of the quantum channel, which can influence the width of the transparency window and the bistable behavior of the mean photon number in cavity a . We also illustrate that the electromagnetical control via quantum channel can be exploited to implement the optical switch and the slow light.
Steady State Turbulent Transport in Magnetic Fusion Plasmas
Lee, W. W.; Ethier, S.; Kolesnikov, R.; Wang, W. X.; Tang, W. M.
2007-12-20
For more than a decade, the study of microturbulence, driven by ion temperature gradient (ITG) drift instabilities in tokamak devices, has been an active area of research in magnetic fusion science for both experimentalists and theorists alike. One of the important impetus for this avenue of research was the discovery of the radial streamers associated the ITG modes in the early nineties using a Particle-In-Cell (PIC) code. Since then, ITG simulations based on the codes with increasing realism have become possible with the dramatic increase in computing power. The notable examples were the demonstration of the importance of nonlinearly generated zonal flows in regulating ion thermal transport and the transition from Bohm to GyroBoham scaling with increased device size. In this paper, we will describe another interesting nonlinear physical process associated with the parallel acceleration of the ions, that is found to play an important role for the steady state turbulent transport. Its discovery is again through the use of the modern massively parallel supercomputers.
Dynamic causal models of steady-state responses
Moran, R.J.; Stephan, K.E.; Seidenbecher, T.; Pape, H.-C.; Dolan, R.J.; Friston, K.J.
2009-01-01
In this paper, we describe a dynamic causal model (DCM) of steady-state responses in electrophysiological data that are summarised in terms of their cross-spectral density. These spectral data-features are generated by a biologically plausible, neural-mass model of coupled electromagnetic sources; where each source comprises three sub-populations. Under linearity and stationarity assumptions, the model's biophysical parameters (e.g., post-synaptic receptor density and time constants) prescribe the cross-spectral density of responses measured directly (e.g., local field potentials) or indirectly through some lead-field (e.g., electroencephalographic and magnetoencephalographic data). Inversion of the ensuing DCM provides conditional probabilities on the synaptic parameters of intrinsic and extrinsic connections in the underlying neuronal network. This means we can make inferences about synaptic physiology, as well as changes induced by pharmacological or behavioural manipulations, using the cross-spectral density of invasive or non-invasive electrophysiological recordings. In this paper, we focus on the form of the model, its inversion and validation using synthetic and real data. We conclude with an illustrative application to multi-channel local field potential data acquired during a learning experiment in mice. PMID:19000769
Fault Wear by Damage Evolution During Steady-State Slip
NASA Astrophysics Data System (ADS)
Lyakhovsky, Vladimir; Sagy, Amir; Boneh, Yuval; Reches, Ze'ev
2014-11-01
Slip along faults generates wear products such as gouge layers and cataclasite zones that range in thickness from sub-millimeter to tens of meters. The properties of these zones apparently control fault strength and slip stability. Here we present a new model of wear in a three-body configuration that utilizes the damage rheology approach and considers the process as a microfracturing or damage front propagating from the gouge zone into the solid rock. The derivations for steady-state conditions lead to a scaling relation for the damage front velocity considered as the wear-rate. The model predicts that the wear-rate is a function of the shear-stress and may vanish when the shear-stress drops below the microfracturing strength of the fault host rock. The simulated results successfully fit the measured friction and wear during shear experiments along faults made of carbonate and tonalite. The model is also valid for relatively large confining pressures, small damage-induced change of the bulk modulus and significant degradation of the shear modulus, which are assumed for seismogenic zones of earthquake faults. The presented formulation indicates that wear dynamics in brittle materials in general and in natural faults in particular can be understood by the concept of a "propagating damage front" and the evolution of a third-body layer.
Steady-state and transient results on insulation materials
Graves, R.S.; Yarbrough, D.W.; McElroy, D.L.; Fine, H.A.
1991-01-01
The Unguarded Thin-Heater Apparatus (UTHA, ASTM C 1114) was used to determine the thermal conductivity (k), specific heat (C), and thermal diffusivity ({alpha}) of selected building materials from 24 to 50{degree}C. Steady-state and transient measurements yielded data on four types of material: gypsum wall board containing 0, 15, and 30 wt % wax; calcium silicate insulations with densities ({rho}) of 307, 444, and 605 kg/m{sup 3}; three wood products: southern yellow pine flooring (575 kg/m{sup 3}), Douglas fir plywood (501 kg/m{sup 3}), and white spruce flooring (452 kg/m{sup 3}); and two cellular plastic foams: extruded polystyrene (30 kg/m{sup 3}) blown with HCFC-142b and polyisocyanurate rigid board (30.2 kg/m{sup 3}) blown with CFC-11. The extruded polystyrene was measured several times after production (25 days, 45 days, 74 days, 131 days, and 227 days). The UTHA is an absolute technique that yields k with an uncertainty of less than {plus minus}2% as determined by modeling, by determinate error analyses, and by use of Standard Reference Materials SRM-1450b and SRM-1451. 37 refs., 5 figs., 10 tabs.
a Steady Thermal State for the Earth's Interior
NASA Astrophysics Data System (ADS)
Andrault, D.; Monteux, J.; Le Bars, M.; Samuel, H.
2015-12-01
Large amounts of heat are permanently lost at the surface yielding the classic view of the Earth continuously cooling down. Contrary to this conventional depiction, we propose that the temperature profile in the deep Earth has remained almost constant for the last ~3 billion years (Ga) or more. The core-mantle boundary (CMB) temperature reached the mantle solidus of 4100 (+/-300) K after complete crystallization of the magma ocean not more than 1 Ga after the Moon-forming impact. The CMB remains at a similar temperature today; seismological evidences of ultra-low velocity zones suggest partial melting in the D"-layer and, therefore, a current temperature at, or just below, the mantle solidus. Such a steady thermal state of the CMB temperature excludes thermal buoyancy and compositional convection from being the predominant mechanisms to power the geodynamo over geological time. An alternative mechanism to produce motion in the outer core is mechanical forcing by tidal distortion and planetary precession. The conversion of gravitational and rotational energies of the Earth-Moon-Sun system to core motions could have supplied the lowermost mantle with a variable intensity heat source through geological time, due to the regime of core instabilities and/or changes in the astronomical forces. This variable heat source could explain the dramatic volcanic events that occurred in the Earth's history.
Steady-state growth of the marine diatom Thalassiosira pseudonana
Olson, R.J.; SooHoo, J.B.; Kiefer, D.A.
1980-09-01
Seasonal studies of the vertical distribution of nitrate, nitrite, and phytoplankton in the oceans and studies using /sup 15/N as a tracer of nitrate metabolism indicate that the reduction of nitrate by phytoplankton is a source of nitrite in the upper waters of the ocean. To better understand this process, the relationship between nitrate uptake and nitrite production has been examined with continuous cultures of the small marine diatom Thalassiosira pseudonana. In a turbidostat culture, the rates of nitrite production by T. Pseudonana increase with light intensity. This process is only loosely coupled to rates of nitrate assimilation since the ratio of net nitrite production to total nitrate assimilation increases with increased rates of growth. In continuous cultures where steady-state concentrations of nitrate and nitrite were varied, T. pseudonana produced nitrite at rates which increased with increasing concentrations of nitrate. Again, the rates of nitrite production were uncoupled from rates of nitrate assimilation. The study was used to derive a mathematical description of nitrate and nitrite metabolism by T. pseudonana. The validity of this model was supported by the results of a study in which /sup 15/N-labeled nitrite was introduced into the continuous culture, and the model was used to examine patterns in distribution of nitrite in the Antarctic Ocean and the Sargasso Sea.
Steady State Analysis of Small Molten Salt Reactor
NASA Astrophysics Data System (ADS)
Yamamoto, Takahisa; Mitachi, Koshi; Suzuki, Takashi
The Molten Salt Reactor (MSR) is a thermal neutron reactor with graphite moderation and operates on the thorium-uranium fuel cycle. The feature of the MSR is that fuel salt flows inside the reactor during the nuclear fission reaction. In the previous study, the authors developed numerical model with which to simulate the effects of fuel salt flow on the reactor characteristics. In this study, we apply the model to the steady-state analysis of a small MSR system and estimate the effects of fuel flow. The model consists of two-group neutron diffusion equations for fast and thermal neutron fluxes, transport equations for six-group delayed neutron precursors and energy conservation equations for fuel salt and the graphite moderator. The following results are obtained: (1) in the rated operation condition, the peaks of the neutron fluxes slightly move toward the bottom from the center of the reactor and the delayed neutron precursors are significantly carried by the fuel salt flow, and (2) the extension of residence time in the external-loop system and the rise of the fuel inflow temperature show weak negative reactivity effects, which decrease the neutron multiplication factor of the small MSR system.
NASA Lewis steady-state heat pipe code users manual
NASA Technical Reports Server (NTRS)
Tower, Leonard K.; Baker, Karl W.; Marks, Timothy S.
1992-01-01
The NASA Lewis heat pipe code was developed to predict the performance of heat pipes in the steady state. The code can be used as a design tool on a personal computer or with a suitable calling routine, as a subroutine for a mainframe radiator code. A variety of wick structures, including a user input option, can be used. Heat pipes with multiple evaporators, condensers, and adiabatic sections in series and with wick structures that differ among sections can be modeled. Several working fluids can be chosen, including potassium, sodium, and lithium, for which monomer-dimer equilibrium is considered. The code incorporates a vapor flow algorithm that treats compressibility and axially varying heat input. This code facilitates the determination of heat pipe operating temperatures and heat pipe limits that may be encountered at the specified heat input and environment temperature. Data are input to the computer through a user-interactive input subroutine. Output, such as liquid and vapor pressures and temperatures, is printed at equally spaced axial positions along the pipe as determined by the user.
Steady-state compartmentalization of lipid membranes by active proteins.
Sabra, M C; Mouritsen, O G
1998-01-01
Using a simple microscopic model of lipid-protein interactions, based on the hydrophobic matching principle, we study some generic aspects of lipid-membrane compartmentalization controlled by a dispersion of active integral membrane proteins. The activity of the proteins is simulated by conformational excitations governed by an external drive, and the deexcitation is controlled by interaction of the protein with its lipid surroundings. In response to the flux of energy into the proteins from the environment and the subsequent dissipation of energy into the lipid bilayer, the lipid-protein assembly reorganizes into a steady-state structure with a typical length scale determined by the strength of the external drive. In the specific case of a mixed dimyristoylphosphatidylcholine-distearoylphosphatidylcholine bilayer in the gel-fluid coexistence region, it is shown explicitly by computer simulation that the activity of an integral membrane protein can lead to a compartmentalization of the lipid-bilayer membrane. The compartmentalization is related to the dynamical process of phase separation and lipid domain formation. PMID:9533687
Classical quasi-steady state reduction-A mathematical characterization
NASA Astrophysics Data System (ADS)
Goeke, Alexandra; Walcher, Sebastian; Zerz, Eva
2017-04-01
We discuss parameter dependent polynomial ordinary differential equations that model chemical reaction networks. By classical quasi-steady state (QSS) reduction we understand the following familiar (heuristically motivated) mathematical procedure: Set the rate of change for certain (a priori chosen) variables equal to zero and use the resulting algebraic equations to obtain a system of smaller dimension for the remaining variables. This procedure will generally be valid only for certain parameter ranges. We start by showing that the reduction is accurate if and only if the corresponding parameter is what we call a QSS parameter value, and that the reduction is approximately accurate if and only if the corresponding parameter is close to a QSS parameter value. The QSS parameter values can be characterized by polynomial equations and inequations, hence parameter ranges for which QSS reduction is valid are accessible in an algorithmic manner. A defining characteristic of a QSS parameter value is that the algebraic variety defined by the QSS relations is invariant for the differential equation. A closer investigation of the associated systems shows the existence of further invariant sets; here singular perturbations enter the picture in a natural manner. We compare QSS reduction and singular perturbation reduction, and show that, while they do not agree in general, they do, up to lowest order in a small parameter, for a quite large and relevant class of examples. This observation, in turn, allows the computation of QSS reductions even in cases where an explicit resolution of the polynomial equations is not possible.
Experimental Realization of Nearly Steady-State Toroidal Electron Plasmas
NASA Astrophysics Data System (ADS)
Stoneking, M. R.
2008-11-01
Non-neutral plasmas are routinely confined in the uniform magnetic field of a Penning-Malmberg trap for arbitrarily long times and approach thermal equilibrium. Theory predicts that dynamically stable and therefore long-lived equilibria exist for non-neutral plasmas confined in the curved, non-uniform field of a toroidal trap, but that ultimately thermal equilibrium states do not exist. On long timescales, the poloidal ExB rotation through the non-uniform toroidal magnetic field leads to magnetic pumping transport. A new experiment has, for the first time, demonstrated the existence of a stable, long-lived (i.e. nearly steady-state) toroidal equilibrium for pure electron plasmas and is poised to observe the magnetic pumping transport mechanism. Electron plasmas with densities of order 10^6 cm-3 are trapped in the Lawrence Non-neutral Torus II for several seconds. LNT II is a high aspect ratio (Ro/a 10), partially toroidal trap (a 270^o arc with Bo=670 G). The m=1 diocotron mode is launched and detected using isolated segments of a fully-sectored conducting boundary and its frequency is used to determine the total trapped charge as a function of time. The observed confinement time ( 3 s) approaches the theoretical limit ( 6 s) set by the magnetic pumping transport mechanism of Crooks and O'Neil. We also present equilibrium modeling and numerical simulation of the toroidal m=1 mode constrained by experimental data. Future work includes the identification of the dominant transport mechanisms via confinement scaling experiments and measurement of the m=2 mode frequency, and development of a strategy for making a transition to fully toroidal confinement. J.P. Marler and M.R. Stoneking, Phys. Rev. Lett. 100, 155001 (2008). S.M. Crooks and T.M. O'Neil, Phys Plamas 3, 2533 (1996).
Hopf and steady state bifurcation analysis in a ratio-dependent predator-prey model
NASA Astrophysics Data System (ADS)
Zhang, Lai; Liu, Jia; Banerjee, Malay
2017-03-01
In this paper, we perform spatiotemporal bifurcation analysis in a ratio-dependent predator-prey model and derive explicit conditions for the existence of non-constant steady states that emerge through steady state bifurcation from related constant steady states. These explicit conditions are numerically verified in details and further compared to those conditions ensuring Turing instability. We find that (1) Turing domain is identical to the parametric domain where there exists only steady state bifurcation, which implies that Turing patterns are stable non-constant steady states, but the opposite is not necessarily true; (2) In non-Turing domain, steady state bifurcation and Hopf bifurcation act in concert to determine the emergent spatial patterns, that is, non-constant steady state emerges through steady state bifurcation but it may be unstable if the destabilising effect of Hopf bifurcation counteracts the stabilising effect of diffusion, leading to non-stationary spatial patterns; (3) Coupling diffusion into an ODE model can significantly enrich population dynamics by inducing alternative non-constant steady states (four different states are observed, two stable and two unstable), in particular when diffusion interacts with different types of bifurcation; (4) Diffusion can promote species coexistence by saving species which otherwise goes to extinction in the absence of diffusion.
2012-09-03
use of so-called probability-one methods [22]. The significant advantage of homotopy method to compute steady state solutions is free of Courant ...A homotopy method based on WENO schemes for solving steady state problems of hyperbolic conservation laws Wenrui Hao∗ Jonathan D. Hauenstein† Chi...robustness of the new method . Keywords homotopy continuation, hyperbolic conservation laws, WENO scheme, steady state problems. ∗Department of Applied and
HELIOS: A high intensity chopper spectrometer at LANSCE
Mason, T.E.; Broholm, C.; Fultz, B.
1998-12-31
A proposal to construct a high intensity chopper spectrometer at LANSCE as part of the SPSS upgrade project is discussed. HELIOS will be optimized for science requiring high sensitivity neutron spectroscopy. This includes studies of phonon density of states in small polycrystalline samples, magnetic excitations in quantum magnets and highly correlated electron systems, as well as parametric studies (as a function of pressure, temperature, or magnetic field) of S(Q,{omega}). By employing a compact design together with the use of supermirror guide in the incident flight path the neutron flux at HELIOS will be significantly higher than any other comparable instrument now operating.
Ho, Pang-Yen; Chuang, Guo-Syong; Chao, An-Chong; Li, Hsing-Ya
2005-05-01
The capacity of complex biochemical reaction networks (consisting of 11 coupled non-linear ordinary differential equations) to show multiple steady states, was investigated. The system involved esterification of ethanol and oleic acid by lipase in an isothermal continuous stirred tank reactor (CSTR). The Deficiency One Algorithm and the Subnetwork Analysis were applied to determine the steady state multiplicity. A set of rate constants and two corresponding steady states are computed. The phenomena of bistability, hysteresis and bifurcation are discussed. Moreover, the capacity of steady state multiplicity is extended to the family of the studied reaction networks.
Bieri, Oliver
2011-02-01
Conceptually, the only flaw in the standard steady-state free precession theory is the assumption of quasi-instantaneous radio-frequency pulses, and 10-20% signal deviations from theory are observed for common balanced steady-state free precession protocols. This discrepancy in the steady-state signal can be resolved by a simple T(2) substitution taking into account reduced transverse relaxation effects during finite radio-frequency excitation. However, finite radio-frequency effects may also affect the transient phase of balanced steady-state free precession, its contrast or its spin-echo nature and thereby have an adverse effect on common steady-state free precession magnetization preparation methods. As a result, an in-depth understanding of finite radio-frequency effects is not only of fundamental theoretical interest but also has direct practical implications. In this article, an analytical solution for balanced steady-state free precession with finite radio-frequency pulses is derived for the transient phase (under ideal conditions) and in the steady state demonstrating that balanced steady-state free precession key features are preserved but revealing an unexpected dependency of finite radio-frequency effects on relaxation times for the transient decay. Finally, the mathematical framework reveals that finite radio-frequency theory can be understood as a generalization of alternating repetition time and fluctuating equilibrium steady-state free precession sequence schemes.
Rod Bundle Heat Transfer: Steady-State Steam Cooling Experiments
Spring, J.P.; McLaughlin, D.M.
2006-07-01
Through the joint efforts of the Pennsylvania State University and the United States Nuclear Regulatory Commission, an experimental rod bundle heat transfer (RBHT) facility was designed and built. The rod bundle consists of a 7 x 7 square pitch array with spacer grids and geometry similar to that found in a modern pressurized water reactor. From this facility, a series of steady-state steam cooling experiments were performed. The bundle inlet Reynolds number was varied from 1 400 to 30 000 over a pressure range from 1.36 to 4 bars (20 to 60 psia). The bundle inlet steam temperature was controlled to be at saturation for the specified pressure and the fluid exit temperature exceeded 550 deg. C in the highest power tests. One important quantity of interest is the local convective heat transfer coefficient defined in terms of the local bulk mean temperature of the flow, local wall temperature, and heat flux. Steam temperatures were measured at the center of selected subchannels along the length of the bundle by traversing miniaturized thermocouples. Using an analogy between momentum and energy transport, a method was developed for relating the local subchannel centerline temperature measurement to the local bulk mean temperature. Wall temperatures were measured using internal thermocouples strategically placed along the length of each rod and the local wall heat flux was obtained from an inverse conduction program. The local heat transfer coefficient was calculated from the data at each rod thermocouple location. The local heat transfer coefficients calculated for locations where the flow was fully developed were compared against several published correlations. The Weisman and El-Genk correlations were found to agree best with the RBHT steam cooling data, especially over the range of turbulent Reynolds numbers. The effect of spacer grids on the heat transfer enhancement was also determined from instrumentation placed downstream of the spacer grid locations. The local
There are no steady state processes in compaction
NASA Astrophysics Data System (ADS)
Dysthe, D. K.
2003-04-01
Compaction of sediments is normally thought to start with grain sliding and cataclastic grain crushing. Then the ductile dissolution-precipitation creep processes take over. Modeling of this process normally neglects all collective rearrangement processes and regard simple packings of grains that slowly deform by steady state pressure solution creep. From simple geometrical reasoning we know, however that imperfect packings of plastic grains must undergo rearrangement during compaction. Such rearrangement will drastically alter the microscopic, or "primitive processes" of compaction. Recent research has questioned the fundamental mechanisms ("primitive processes") of dissolution-precipitation creep. Do grain contacts heal or dissolve? Why is there asymmetric dissolution? Does pressure solution creep in single contacts ever reach steady state? Can transient free face dissolution feed back on pressure solution creep in the contacts? The emerging radical change in our understanding of dissolution-precipitation creep as a dynamic, transient process is driven by new experiments and reevaluation of the fundamental theory. The same change in viewpoint is necessary on all time and length scales. I will present experiments [1-8] and simulations [9-11] of complex compaction behaviour [1], transient primitive processes of pressure solution creep in the contacts [2-4], free face dissolution [5] and crack healing [6]. I will also show that macroscopic observation of compaction shows smooth, universal behaviour [7]. Microscopic observation of compaction shows transient collective behaviour at all scales. Evidence points in the direction that compaction is dominated by transient processes with interacting instabilities. The interaction causes intermittency or switching between processes. A new, more complex theory of compaction is necessary to explain how the cooperative microscopic phenomena contribute to the simple, universal, macroscopic behaviour. 1. Uri, L., et. al., in
Phencyclidine Disrupts the Auditory Steady State Response in Rats
Leishman, Emma; O’Donnell, Brian F.; Millward, James B.; Vohs, Jenifer L.; Rass, Olga; Krishnan, Giri P.; Bolbecker, Amanda R.; Morzorati, Sandra L.
2015-01-01
The Auditory Steady-State Response (ASSR) in the electroencephalogram (EEG) is usually reduced in schizophrenia (SZ), particularly to 40 Hz stimulation. The gamma frequency ASSR deficit has been attributed to N-methyl-D-aspartate receptor (NMDAR) hypofunction. We tested whether the NMDAR antagonist, phencyclidine (PCP), produced similar ASSR deficits in rats. EEG was recorded from awake rats via intracranial electrodes overlaying the auditory cortex and at the vertex of the skull. ASSRs to click trains were recorded at 10, 20, 30, 40, 50, and 55 Hz and measured by ASSR Mean Power (MP) and Phase Locking Factor (PLF). In Experiment 1, the effect of different subcutaneous doses of PCP (1.0, 2.5 and 4.0 mg/kg) on the ASSR in 12 rats was assessed. In Experiment 2, ASSRs were compared in PCP treated rats and control rats at baseline, after acute injection (5 mg/kg), following two weeks of subchronic, continuous administration (5 mg/kg/day), and one week after drug cessation. Acute administration of PCP increased PLF and MP at frequencies of stimulation below 50 Hz, and decreased responses at higher frequencies at the auditory cortex site. Acute administration had a less pronounced effect at the vertex site, with a reduction of either PLF or MP observed at frequencies above 20 Hz. Acute effects increased in magnitude with higher doses of PCP. Consistent effects were not observed after subchronic PCP administration. These data indicate that acute administration of PCP, a NMDAR antagonist, produces an increase in ASSR synchrony and power at low frequencies of stimulation and a reduction of high frequency (> 40 Hz) ASSR activity in rats. Subchronic, continuous administration of PCP, on the other hand, has little impact on ASSRs. Thus, while ASSRs are highly sensitive to NMDAR antagonists, their translational utility as a cross-species biomarker for NMDAR hypofunction in SZ and other disorders may be dependent on dose and schedule. PMID:26258486
Steady state growth of E. Coli in low ammonium environment
NASA Astrophysics Data System (ADS)
Kim, Minsu; Deris, Barret; Zhang, Zhongge; Hwa, Terry
2011-03-01
Ammonium is the preferred nitrogen source for many microorganisms. In medium with low ammonium concentrations, enteric bacteria turn on the nitrogen responsive (ntr) genes to assimilate ammonium. Two proteins in E. coli, Glutamine synthetase (GS) and the Ammonium/methylammonium transporter AmtB play crucial roles in this regard. GS is the major ammonium assimilation enzyme below 1mM of NH4 + . AmtB is an inner membrane protein that transports NH4 + across the cell membrane against a concentration gradient. In order to study ammonium uptake at low NH4 + concentration at neutral pH, we developed a microfluidic flow chamber that maintains a homogenous nutrient environment during the course of exponential cell growth, even at very low concentration of nutrients. Cell growth can be accurately monitored using time-lapse microscopy. We followed steady state growth down to micro-molar range of NH4 + for the wild type and Δ amtB strains. The wild type strain is able to maintain the growth rate from 10mM down to a few uM of NH4 + , while the mutant exhibited reduced growth below ~ 20 ~uM of NH4 + . Simultaneous characterization of the expression levels of GS and AmtB using fluorescence reporters reveals that AmtB is turned on already at 1mM, but contributes to function only below ~ 30 ~uM in the wild-type. Down to ~ 20 ~uM of NH4 + , E.~coli can compensate the loss of AmtB by GS alone.
Steady-state and transient electronic dynamics in granular metals
NASA Astrophysics Data System (ADS)
Chen, Wei
In this thesis two very different approaches, steady state and transient, are taken to help understand the electronic dynamics in the nanogranular Cux(SiO2)1-x composite thin films. The electrical conductivity and thermopower are measured from 2 K to room temperature with the Cu volume fraction x varying from 1 down to 0.43. At low temperatures, a T dependence of the electrical conductivity is observed well above the percolation threshold due to the disorder-enhanced electron-electron interaction and as the metal-insulator transition is approached, the electrical conductivity assumes a T1/3 dependence. The thermopower is found to be small and rather insensitive to the degree of disorder in the system. It varies linearly with temperatures at both low and high temperatures. Annealing has considerable influence to the behavior of the electrical conductivity while introducing little changes to the thermopower. Femtosecond pump-probe experiments were performed on a series of Cu x(SiO2)1-x composite films with volume fraction x varying from 0.7 to 1.0 to study the reflectivity change DeltaR/R as a function of composition and temperature. It is discovered that DeltaR/R undergoes drastic changes as the metal content is lowered. Very small amount of SiO 2 inclusions can start to result in qualitatively different Delta R/R behavior from pure Cu. Changes in the dielectric constant of Cu are investigated and possible explanations for the DeltaR/R behaviors in the composite films are discussed.
A steady-state model of the lunar ejecta cloud
NASA Astrophysics Data System (ADS)
Christou, Apostolos
2014-05-01
Every airless body in the solar system is surrounded by a cloud of ejecta produced by the impact of interplanetary meteoroids on its surface [1]. Such ``dust exospheres'' have been observed around the Galilean satellites of Jupiter [2,3]. The prospect of long-term robotic and human operations on the Moon by the US and other countries has rekindled interest on the subject [4]. This interest has culminated with the - currently ongoing - investigation of the Moon's dust exosphere by the LADEE spacecraft [5]. Here a model is presented of a ballistic, collisionless, steady state population of ejecta launched vertically at randomly distributed times and velocities and moving under constant gravity. Assuming a uniform distribution of launch times I derive closed form solutions for the probability density functions (pdfs) of the height distribution of particles and the distribution of their speeds in a rest frame both at the surface and at altitude. The treatment is then extended to particle motion with respect to a moving platform such as an orbiting spacecraft. These expressions are compared with numerical simulations under lunar surface gravity where the underlying ejection speed distribution is (a) uniform (b) a power law. I discuss the predictions of the model, its limitations, and how it can be validated against near-surface and orbital measurements.[1] Gault, D. Shoemaker, E.M., Moore, H.J., 1963, NASA TN-D 1767. [2] Kruger, H., Krivov, A.V., Hamilton, D. P., Grun, E., 1999, Nature, 399, 558. [3] Kruger, H., Krivov, A.V., Sremcevic, M., Grun, E., 2003, Icarus, 164, 170. [4] Grun, E., Horanyi, M., Sternovsky, Z., 2011, Planetary and Space Science, 59, 1672. [5] Elphic, R.C., Hine, B., Delory, G.T., Salute, J.S., Noble, S., Colaprete, A., Horanyi, M., Mahaffy, P., and the LADEE Science Team, 2014, LPSC XLV, LPI Contr. 1777, 2677.
Impact of aquifer desaturation on steady-state river seepage
NASA Astrophysics Data System (ADS)
Morel-Seytoux, Hubert J.; Miracapillo, Cinzia; Mehl, Steffen
2016-02-01
Flow exchange between surface and ground water is of great importance be it for beneficial allocation and use of the water resources or for the proper exercise of water rights. That exchange can take place under a saturated or unsaturated flow regime. Which regimes occur depend on conditions in the vicinity of the interactive area. Withdrawals partially sustained by seepage may not bring about desaturation but greater amounts eventually will. The problem considered in this paper deals only with the steady-state case. It is meant as a first step toward a simple, yet accurate and physically based treatment of the transient situation. The primary purpose of the article is to provide simple criteria for determination of the initiation of desaturation in an aquifer originally in saturated hydraulic connection with a river or a recharge area. The extent of the unsaturated zone in the aquifer will increase with increasing withdrawals while at the same time the seepage rate from the river increases. However the seepage increase will stop once infiltration takes place strictly by gravity in the aquifer and is no longer opposed by the capillary rise from the water table below the riverbed. Following desaturation simple criteria are derived and simple analytical formulae provided to estimate the river seepage based on the position of the water table mound below the clogging layer and at some distance away from the river bank. They fully account for the unsaturated flow phenomena, including the existence of a drainage entry pressure. Two secondary objectives were to verify that (1) the assumption of uniform vertical flow through a clogging layer and that (2) the approximation of the water table mound below the seepage area as a flat surface were both reasonably legitimate. This approach will be especially advantageous for the implementation of the methodology in large-scale applications of integrated hydrologic models used for management.
Steady state risetimes of shock waves in the atmosphere
NASA Technical Reports Server (NTRS)
Raspet, Richard; Bass, Henry; Yao, Lixin; Wu, Wenliang
1992-01-01
A square wave shape is used in the Pestorius algorithm to calculate the risetime of a step shock in the atmosphere. These results agree closely with steady shock calculations. The healing distance of perturbed shocks due to finite wave effects is then investigated for quasi-steady shocks. Perturbed 100 Pa shocks require on the order of 1.0 km travel distance to return to within 10 percent of their steady shock risetime. For 30 Pa shocks, the minimum recovery distance increases to 3.0 km. It is unlikely that finite wave effects can remove the longer risetimes and irregular features introduced into the sonic boom by turbulent scattering in the planetary boundary layer.
Lead Slowing-Down Spectrometer Research at Lansce
NASA Astrophysics Data System (ADS)
Haight, R. C.; Bredeweg, T. A.; Devlin, M.; Gavron, A.; Jandel, M.; O'Donnell, J. M.; Wender, S. A.; Bélier, G.; Granier, T.; Laurent, B.; Taieb, J.; Danon, Y.; Thompson, J. T.
2013-03-01
The lead slowing-down spectrometer (LSDS) at Los Alamos is a 20 ton cube of lead with numerous channels, one for the proton beam from the LANSCE accelerator and others for samples and detectors. A pulsed spallation neutron source at the center of the cube is produced by the 800 MeV proton beam incident on an air-cooled tungsten target. Neutrons from this source are quickly downscattered by various reactions until their energies are less than the first excited state of 207Pb (0.57 MeV). After that, the neutrons slow down by elastic scattering where they lose on the average 1% of their energy per collision. The mean energy of the neutron distribution then changes with time as
Progress Towards High-Performance, Steady-State Spherical Torus
Lawrence Livermore National Laboratory
2004-01-04
Research on the spherical torus (or spherical tokamak) (ST) is being pursued to explore the scientific benefits of modifying the field line structure from that in more moderate aspect ratio devices, such as the conventional tokamak. The ST experiments are being conducted in various US research facilities including the MA-class National Spherical Torus Experiment (NSTX) at Princeton, and three medium sized ST research facilities: PEGASUS at University of Wisconsin, HIT-II at University of Washington, and CDX-U at Princeton. In the context of the fusion energy development path being formulated in the US, an ST-based Component Test Facility (CTF) and, ultimately a Demo device, are being discussed. For these, it is essential to develop high performance, steady-state operational scenarios. The relevant scientific issues are energy confinement, MHD stability at high beta ({beta}), non-inductive sustainment, Ohmic-solenoid-free start-up, and power and particle handling. In the confinement area, the NSTX experiments have shown that the confinement can be up to 50% better than the ITER-98-pby2 H-mode scaling, consistent with the requirements for an ST-based CTF and Demo. In NSTX, CTF-relevant average toroidal beta values {beta}{sub T} of up to 35% with a near unity central {beta}{sub T} have been obtained. NSTX will be exploring advanced regimes where {beta}{sub T} up to 40% can be sustained through active stabilization of resistive wall modes. To date, the most successful technique for non-inductive sustainment in NSTX is the high beta poloidal regime, where discharges with a high non-inductive fraction ({approx}60% bootstrap current+NBI current drive) were sustained over the resistive skin time. Research on radio-frequency (RF) based heating and current drive utilizing high harmonic fastwave and electron Bernstein wave is also pursued on NSTX, PEGASUS, and CDX-U. For non-inductive start-up, the coaxial helicity injection, developed in HIT/HIT-II, has been adopted on NSTX
40 CFR 92.130 - Determination of steady-state concentrations.
Code of Federal Regulations, 2013 CFR
2013-07-01
... concentrations. 92.130 Section 92.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....130 Determination of steady-state concentrations. (a)(1) For HC and NOX emissions, a steady-state concentration measurement, measured after 300 seconds (or 840 seconds for notch 8) of testing shall be...
40 CFR 92.130 - Determination of steady-state concentrations.
Code of Federal Regulations, 2010 CFR
2010-07-01
... concentrations. 92.130 Section 92.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....130 Determination of steady-state concentrations. (a)(1) For HC and NOX emissions, a steady-state concentration measurement, measured after 300 seconds (or 840 seconds for notch 8) of testing shall be...
40 CFR 92.130 - Determination of steady-state concentrations.
Code of Federal Regulations, 2011 CFR
2011-07-01
... concentrations. 92.130 Section 92.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....130 Determination of steady-state concentrations. (a)(1) For HC and NOX emissions, a steady-state concentration measurement, measured after 300 seconds (or 840 seconds for notch 8) of testing shall be...
40 CFR 92.130 - Determination of steady-state concentrations.
Code of Federal Regulations, 2012 CFR
2012-07-01
... concentrations. 92.130 Section 92.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....130 Determination of steady-state concentrations. (a)(1) For HC and NOX emissions, a steady-state concentration measurement, measured after 300 seconds (or 840 seconds for notch 8) of testing shall be...
40 CFR 92.130 - Determination of steady-state concentrations.
Code of Federal Regulations, 2014 CFR
2014-07-01
... concentrations. 92.130 Section 92.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....130 Determination of steady-state concentrations. (a)(1) For HC and NOX emissions, a steady-state concentration measurement, measured after 300 seconds (or 840 seconds for notch 8) of testing shall be...
Constructive interference in steady-state/FIESTA-C clinical applications in neuroimaging.
Kulkarni, Makarand; Kulkami, Makarand
2011-04-01
High spatial resolution is one of the major problems in neuroimaging, particularly in cranial and spinal nerve imaging. Constructive interference in steady-state/fast imaging employing steady-state acquisition with phase cycling is a robust sequence in imaging the cranial and spinal nerve pathologies. This pictorial review is a concise article about the applications of this sequence in neuroimaging with clinical examples.
40 CFR 85.2230 - Steady state test dynamometer-EPA 91.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Steady state test dynamometer-EPA 91. 85.2230 Section 85.2230 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Warranty Short Tests § 85.2230 Steady state test dynamometer—EPA 91. (a) Special calendar and model...
Steady-state bumpless transfer under controller uncertainty using the state/output feedback topology
Zheng, K.; Lee, A.H.; Bentsman, J.; Taft, C.W.
2006-01-15
Linear quadratic (LQ) bumpless transfer design introduced recently by Turner and Walker gives a very convenient and straightforward computational procedure for the steady-state bumpless transfer operator synthesis. It is, however, found to be incapable of providing convergence of the output of the offline controller to that of the online controller in several industrial applications, producing bumps in the plant output in the wake of controller transfer. An examination of this phenomenon reveals that the applications in question are characterized by a significant mismatch, further referred to as controller uncertainty, between the dynamics of the implemented controllers and their models used in the transfer operator computation. To address this problem, while retaining the convenience of the Turner and Walker design, a novel state/output feedback bumpless transfer topology is introduced that employs the nominal state of the offline controller and, through the use of an additional controller/model mismatch compensator, also the offline controller output. A corresponding steady-state bumpless transfer design procedure along with the supporting theory is developed for a large class of systems. Due to these features, it is demonstrated to solve a long-standing problem of high-quality steady-state bumpless transfer from the industry standard low-order nonlinear multiloop PID-based controllers to the modern multiinput-multioutput (MIMO) robust controllers in the megawatt/throttle pressure control of a typical coal-fired boiler/turbine unit.
Phased Array Ghost Elimination (PAGE) for Segmented SSFP Imaging With Interrupted Steady-State
Kellman, Peter; Guttman, Michael A.; Herzka, Daniel A.; McVeigh, Elliot R.
2007-01-01
Steady-state free precession (SSFP) has recently proven to be valuable for cardiac imaging due to its high signal-to-noise ratio and blood-myocardium contrast. Data acquired using ECG-triggered, segmented sequences during the approach to steady-state, or return to steady-state after interruption, may have ghost artifacts due to periodic k-space distortion. Schemes involving several preparatory RF pulses have been proposed to restore steady-state, but these consume imaging time during early systole. Alternatively, the phased-array ghost elimination (PAGE) method may be used to remove ghost artifacts from the first several frames. PAGE was demonstrated for cardiac cine SSFP imaging with interrupted steady-state using a simple alpha/2 magnetization preparation and storage scheme and a spatial tagging preparation. PMID:12465121
Reis, Renata A G; Ferreira, Patricia; Medina, Milagros; Nonato, M Cristina
2016-03-01
Leishmania major dihydro-orotate dehydrogenase (DHODHLm) has been considered as a potential therapeutic target against leishmaniasis. DHODHLm, a member of class 1A DHODH, oxidizes dihydro-orotate (DHO) to orotate (ORO) during pyrimidine biosynthesis using fumarate (FUM) as the oxidizing substrate. In the present study, the chemistry of reduction and reoxidation of the flavin mononucleotide (FMN) cofactor in DHODHLm was examined by steady- and pre-steady state kinetics under both aerobic and anaerobic environments. Our results provide for the first time the experimental evidence of co-operative behaviour in class 1A DHODH regulated by DHO binding and reveal that the initial reductive flavin half-reaction follows a mechanism with two steps. The first step is consistent with FMN reduction and shows a hyperbolic dependence on the DHO concentration with a limiting rate (kred) of 110±6 s(-1) and a K(DHO) d of 180±27 μM. Dissociation of the reduced flavin-ORO complex corresponds to the second step, with a limiting rate of 6 s(-1). In the oxidative half-reaction, the oxygen-sensitive reoxidation of the reduced FMN cofactor of DHODHLm by FUM exhibited a hyperbolic saturation profile dependent on FUM concentration allowing estimation of K(FUM) d and the limiting rate (kreox) of 258±53 μM and 35±2 s(-1), respectively. Comparison between steady- and pre-steady-state parameters together with studies of interaction for DHODHLm with both ORO and succinate (SUC), suggests that ORO release is the rate-limiting step in overall catalysis. Our results provide evidence of mechanistic differences between class 1A and class 2 individual half-reactions to be exploited for the development of selective inhibitors.
On the use of steady-state signal equations for 2D TrueFISP imaging.
Coolen, Bram F; Heijman, Edwin; Nicolay, Klaas; Strijkers, Gustav J
2009-07-01
To explain the signal behavior in 2D-TrueFISP imaging, a slice excitation profile should be considered that describes a variation of effective flip angles and magnetization phases after excitation. These parameters can be incorporated into steady-state equations to predict the final signal within a pixel. The use of steady-state equations assumes that excitation occurs instantaneously, although in reality this is a nonlinear process. In addition, often the flip angle variation within the slice excitation profile is solely considered when using steady-state equations, while TrueFISP is especially known for its sensitivity to phase variations. The purpose of this study was therefore to evaluate the precision of steady-state equations in calculating signal intensities in 2D TrueFISP imaging. To that end, steady-state slice profiles and corresponding signal intensities were calculated as function of flip angle, RF phase advance and pulse shape. More complex Bloch simulations were considered as a gold standard, which described every excitation within the sequence until steady state was reached. They were used to analyze two different methods based on steady-state equations. In addition, measurements on phantoms were done with corresponding imaging parameters. Although the Bloch simulations described the steady-state slice profile formation better than methods based on steady-state equations, the latter performed well in predicting the steady-state signal resulting from it. In certain cases the phase variation within the slice excitation profile did not even have to be taken into account.
NASA Astrophysics Data System (ADS)
McLaren, Robert; Wojtal, Patryk
2013-04-01
Nitrous acid (HONO) is an important radical precursor in the troposphere. Recent consensus suggests that HONO is formed in the dark through the heterogeneous hydrolysis of NO2 on surfaces (2 NO2 + H2O -> HONO + HNO3), largely dominated by hydrolysis on ground surfaces and a smaller contribution from aerosol surfaces. Frequently a steady state of HONO is observed (dHONO/dt ~ 0) at night, which has been ascribed to a balance between heterogeneous formation and dry deposition. The fate of the surface deposited HONO remains an open question with the possibilities including the permanent loss of N(III), accumulation of surface reservoirs of N(III) at night, and/or a full dynamic equilibrium that partitions HONO between the atmosphere and water on the surface. Surface reservoirs of N(III) accumulated at night could act as a source of HONO the next day. Here we report measurements of HONO by DOAS in Toronto for a 1-year period. Of interest is the frequently observed phenomena of a fast approach to a steady state at sunset with rates of increase of d[HONO]/dt = 1.4 ppb/hr (with snow cover) and long periods in which the mixing ratio of HONO is constant with a median level of ~ 1.1 ppb. We discuss these observations in the context of the steady state being attributable to a dynamic equilibrium state.
Digital acquisition development for neutron induced fission studies at LANSCE
NASA Astrophysics Data System (ADS)
Richman, Debra; O'Donnell, John; Couture, Aaron; Mosby, Shea; Wender, Steve
2013-10-01
The Los Alamos Neutron Science Center (LANSCE) is a neutron time of flight facility with a diverse group of experiments dedicated to the study of neutron induced reactions. A powerful proton LINAC is used to produce multiple pulsed neutron beams for which monitoring is required to track the neutron flux and energy distribution for each pulse. Digital DAQ techniques lend themselves well to beam monitoring and many of the experiments. Significant effort is being put into transitioning several traditional analog DAQ systems to state of the art digital systems. The Irradiation of Chips and Electronics (ICE House) and the Total Kinetic Energy of Fission (TKE) experiments are both transitioning to digital for the fall 2013 LANSCE run cycle. These new DAQ systems were built using the CAEN VME digitizer family, and both systems will benefit from reduced module count and zero deadtime. The TKE experiment utilizes FPGA firmware to streamline the acquisition system, as well as provide additional data for further analysis. Details of the implementation process along with preliminary data from both experiments will be presented.
Efficient Steady-State Solution Techniques for Variably Saturated Groundwater Flow
NASA Astrophysics Data System (ADS)
Farthing, M. W.; Kees, C. E.; Coffey, T. S.; Kelley, C. T.; Miller, C. T.
2002-12-01
We consider the simulation of steady-state variably saturated groundwater flow using Richards' equation. The difficulties associated with solving Richards' equation numerically are well known. Most discretization approaches for Richards' equation lead to nonlinear systems that are large and difficult to solve. The solution of nonlinear systems for steady-state problems can be particularly challenging, since a good initial guess for the steady-state solution is often hard to obtain, and the resulting linear systems may be poorly scaled. Common approaches like modified Picard iteration or variations of Newton's method have their advantages but perform poorly with standard globalization techniques under certain conditions. Pseudo-transient continuation has been used in computational fluid dynamics for some time to obtain steady-state solutions for problems in which Newton's method with standard line-search strategies fails. It combines aspects of backward Euler time integration and Newton's method to select intermediate estimates of the steady-state solution. In this work, we examine the use of pseudo-transient continuation methods for Richards' equation. We evaluate their performance for steady-state problems in heterogeneous domains by comparing them with Newton's method using standard globalization techniques. We investigate the methods' performance with both direct and preconditioned Krylov iterative linear solvers. We then make recommendations for robust and efficient approaches to obtain steady-state solutions for Richards' equation under a variety of conditions.
Science-based stockpile stewardship at LANSCE
Browne, J.
1995-10-01
Let me tell you a little about the Los Alamos Neutron Science Center (LANSCE) and how some of the examples you heard about from Sig Hecker and John Immele fit together in this view of a different world in the future where defense, basic and industrial research overlap. I am going to talk about science-based stockpile stewardship at LANSCE; the accelerator production of tritium (APT), which I think has a real bearing on the neutron road map; the world-class neutron science user facility, for which I will provide some examples so you can see the connection with defense science; and lastly, testing concepts for a high-power spallation neutron target and waste transmutation.
Mulukutla, Bhanu Chandra; Yongky, Andrew; Grimm, Simon; Daoutidis, Prodromos; Hu, Wei-Shou
2015-01-01
Cultured mammalian cells exhibit elevated glycolysis flux and high lactate production. In the industrial bioprocesses for biotherapeutic protein production, glucose is supplemented to the culture medium to sustain continued cell growth resulting in the accumulation of lactate to high levels. In such fed-batch cultures, sometimes a metabolic shift from a state of high glycolysis flux and high lactate production to a state of low glycolysis flux and low lactate production or even lactate consumption is observed. While in other cases with very similar culture conditions, the same cell line and medium, cells continue to produce lactate. A metabolic shift to lactate consumption has been correlated to the productivity of the process. Cultures that exhibited the metabolic shift to lactate consumption had higher titers than those which didn't. However, the cues that trigger the metabolic shift to lactate consumption state (or low lactate production state) are yet to be identified. Metabolic control of cells is tightly linked to growth control through signaling pathways such as the AKT pathway. We have previously shown that the glycolysis of proliferating cells can exhibit bistability with well-segregated high flux and low flux states. Low lactate production (or lactate consumption) is possible only at a low glycolysis flux state. In this study, we use mathematical modeling to demonstrate that lactate inhibition together with AKT regulation on glycolysis enzymes can profoundly influence the bistable behavior, resulting in a complex steady-state topology. The transition from the high flux state to the low flux state can only occur in certain regions of the steady state topology, and therefore the metabolic fate of the cells depends on their metabolic trajectory encountering the region that allows such a metabolic state switch. Insights from such switch behavior present us with new means to control the metabolism of mammalian cells in fed-batch cultures.
The condensation of ampholytes in steady state moving boundaries - Analysis by computer simulation
NASA Technical Reports Server (NTRS)
Mosher, Richard A.; Thormann, Wolfgang
1986-01-01
A digital simulation of the behavior of amphoteric sample components in moving steady state boundaries is presented. Complete computer simulation data, including profiles of concentration, conductivity and pH as functions of time, are given for both cationic and anionic electrolyte configurations which incorporate one amphoteric sample constituent. The condensation of ampholytes in steady state moving boundaries is shown to proceed via an isotachophoretic mechanism and not by isoelectric focusing. Mobility (velocity) relationships necessary for sample components to form steady state zones are discussed.
A closed-loop control scheme for steering steady states of glycolysis and glycogenolysis pathway.
Panja, Surajit; Patra, Sourav; Mukherjee, Anirban; Basu, Madhumita; Sengupta, Sanghamitra; Dutta, Pranab K
2013-01-01
Biochemical networks normally operate in the neighborhood of one of its multiple steady states. It may reach from one steady state to other within a finite time span. In this paper, a closed-loop control scheme is proposed to steer states of the glycolysis and glycogenolysis (GG) pathway from one of its steady states to other. The GG pathway is modeled in the synergism and saturation system formalism, known as S-system. This S-system model is linearized into the controllable Brunovsky canonical form using a feedback linearization technique. For closed-loop control, the linear-quadratic regulator (LQR) and the linear-quadratic gaussian (LQG) regulator are invoked to design a controller for tracking prespecified steady states. In the feedback linearization technique, a global diffeomorphism function is proposed that facilitates in achieving the regulation requirement. The robustness of the regulated GG pathway is studied considering input perturbation and with measurement noise.
LANSCE nuclear science facilities and activities
Nelson, Ronald O
2010-01-01
Nuclear science activities at the Los Alamos Neutron Science Center (LANSCE) encompass measurements spanning the neutron energy range from thermal to 600 MeV. The neutron sources use spallation of the LANSCE 800 MeV pulsed proton beam with the time-of-flight technique to measure properties of neutron-induced reactions as a function of energy over this large energy range. Current experiments are conducted at the Lujan Center moderated neutron source, the unmoderated WNR target, and with a lead-slowing-down spectrometer. Instruments in use include the DANCE array of BaF{sub 2} scintillators for neutron capture studies, the FIGARO array of liquid scintillator neutron detectors, the GEANIE array of high-resolution HPGe x-ray and gamma-ray detectors, and a number of fission chambers, and other detectors. The LANL capabilities for production and handling of radioactive materials coupled with the neutron sources and detectors at LANSCE are enabling new and challenging measurements for a variety of applications including nuclear energy and nuclear astrophysics. An overview of recent research and examples of results is presented.
Absolute Steady-State Thermal Conductivity Measurements by Use of a Transient Hot-Wire System.
Roder, H M; Perkins, R A; Laesecke, A; Nieto de Castro, C A
2000-01-01
A transient hot-wire apparatus was used to measure the thermal conductivity of argon with both steady-state and transient methods. The effects of wire diameter, eccentricity of the wire in the cavity, axial conduction, and natural convection were accounted for in the analysis of the steady-state measurements. Based on measurements on argon, the relative uncertainty at the 95 % level of confidence of the new steady-state measurements is 2 % at low densities. Using the same hot wires, the relative uncertainty of the transient measurements is 1 % at the 95 % level of confidence. This is the first report of thermal conductivity measurements made by two different methods in the same apparatus. The steady-state method is shown to complement normal transient measurements at low densities, particularly for fluids where the thermophysical properties at low densities are not known with high accuracy.
Spin-locked balanced steady-state free-precession (slSSFP).
Witschey, Walter R T; Borthakur, Ari; Elliott, Mark A; Magland, Jeremy; McArdle, Erin L; Wheaton, Andrew; Reddy, Ravinder
2009-10-01
A spin-locked balanced steady-state free-precession (slSSFP) pulse sequence is described that combines a balanced gradient-echo acquisition with an off-resonance spin-lock pulse for fast MRI. The transient and steady-state magnetization trajectory was solved numerically using the Bloch equations and was shown to be similar to balanced steady-state free-precession (bSSFP) for a range of T(2)/T(1) and flip angles, although the slSSFP steady-state could be maintained with considerably lower radio frequency (RF) power. In both simulations and brain scans performed at 7T, slSSFP was shown to exhibit similar contrast and signal-to-noise ratio (SNR) efficiency to bSSFP, but with significantly lower power.
Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X
Bosch, H.-S.; Wolf, R. C.; Andreeva, T.; Cardella, A; Erckmann, V.; Gantenbein, G; Hathiramani, D; Kasparek, W; Klinger, T.; Koenig, R; Kornejew, P; Laqua, H P; Lechte, C; Michel, G; Peacock, A.; Sunn Pedersen, T; Thumm, M; Turkin, Yu.; Wegener, Lutz; Werner, A.; Zhang, D; Beidler, C.; Bozhenkov, S.; Brown, T.; Geiger, J.; Harris, Jeffrey H; Heitzenroeder, P.; Lumsdaine, Arnold; Maassberg, H.; Marushchenko, N B; Neilson, G. H.; Otte, M; Rummel, Thomas; Spong, Donald A; Tretter, Jorg
2013-01-01
The next step in the Wendelstein stellarator line is the large superconducting device Wendelstein 7-X, currently under construction in Greifswald, Germany. Steady-state operation is an intrinsic feature of stellarators, and one key element of the Wendelstein 7-X mission is to demonstrate steady-state operation under plasma conditions relevant for a fusion power plant. Steady-state operation of a fusion device, on the one hand, requires the implementation of special technologies, giving rise to technical challenges during the design, fabrication and assembly of such a device. On the other hand, also the physics development of steady-state operation at high plasma performance poses a challenge and careful preparation. The electron cyclotron resonance heating system, diagnostics, experiment control and data acquisition are prepared for plasma operation lasting 30 min. This requires many new technological approaches for plasma heating and diagnostics as well as new concepts for experiment control and data acquisition.
Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X
NASA Astrophysics Data System (ADS)
Bosch, H.-S.; Wolf, R. C.; Andreeva, T.; Baldzuhn, J.; Birus, D.; Bluhm, T.; Bräuer, T.; Braune, H.; Bykov, V.; Cardella, A.; Durodié, F.; Endler, M.; Erckmann, V.; Gantenbein, G.; Hartmann, D.; Hathiramani, D.; Heimann, P.; Heinemann, B.; Hennig, C.; Hirsch, M.; Holtum, D.; Jagielski, J.; Jelonnek, J.; Kasparek, W.; Klinger, T.; König, R.; Kornejew, P.; Kroiss, H.; Krom, J. G.; Kühner, G.; Laqua, H.; Laqua, H. P.; Lechte, C.; Lewerentz, M.; Maier, J.; McNeely, P.; Messiaen, A.; Michel, G.; Ongena, J.; Peacock, A.; Pedersen, T. S.; Riedl, R.; Riemann, H.; Rong, P.; Rust, N.; Schacht, J.; Schauer, F.; Schroeder, R.; Schweer, B.; Spring, A.; Stäbler, A.; Thumm, M.; Turkin, Y.; Wegener, L.; Werner, A.; Zhang, D.; Zilker, M.; Akijama, T.; Alzbutas, R.; Ascasibar, E.; Balden, M.; Banduch, M.; Baylard, Ch.; Behr, W.; Beidler, C.; Benndorf, A.; Bergmann, T.; Biedermann, C.; Bieg, B.; Biel, W.; Borchardt, M.; Borowitz, G.; Borsuk, V.; Bozhenkov, S.; Brakel, R.; Brand, H.; Brown, T.; Brucker, B.; Burhenn, R.; Buscher, K.-P.; Caldwell-Nichols, C.; Cappa, A.; Cardella, A.; Carls, A.; Carvalho, P.; Ciupiński, Ł.; Cole, M.; Collienne, J.; Czarnecka, A.; Czymek, G.; Dammertz, G.; Dhard, C. P.; Davydenko, V. I.; Dinklage, A.; Drevlak, M.; Drotziger, S.; Dudek, A.; Dumortier, P.; Dundulis, G.; Eeten, P. v.; Egorov, K.; Estrada, T.; Faugel, H.; Fellinger, J.; Feng, Y.; Fernandes, H.; Fietz, W. H.; Figacz, W.; Fischer, F.; Fontdecaba, J.; Freund, A.; Funaba, T.; Fünfgelder, H.; Galkowski, A.; Gates, D.; Giannone, L.; García Regaña, J. M.; Geiger, J.; Geißler, S.; Greuner, H.; Grahl, M.; Groß, S.; Grosman, A.; Grote, H.; Grulke, O.; Haas, M.; Haiduk, L.; Hartfuß, H.-J.; Harris, J. H.; Haus, D.; Hein, B.; Heitzenroeder, P.; Helander, P.; Heller, R.; Hidalgo, C.; Hildebrandt, D.; Höhnle, H.; Holtz, A.; Holzhauer, E.; Holzthüm, R.; Huber, A.; Hunger, H.; Hurd, F.; Ihrke, M.; Illy, S.; Ivanov, A.; Jablonski, S.; Jaksic, N.; Jakubowski, M.; Jaspers, R.; Jensen, H.; Jenzsch, H.; Kacmarczyk, J.; Kaliatk, T.; Kallmeyer, J.; Kamionka, U.; Karaleviciu, R.; Kern, S.; Keunecke, M.; Kleiber, R.; Knauer, J.; Koch, R.; Kocsis, G.; Könies, A.; Köppen, M.; Koslowski, R.; Koshurinov, J.; Krämer-Flecken, A.; Krampitz, R.; Kravtsov, Y.; Krychowiak, M.; Krzesinski, G.; Ksiazek, I.; Kubkowska, M.; Kus, A.; Langish, S.; Laube, R.; Laux, M.; Lazerson, S.; Lennartz, M.; Li, C.; Lietzow, R.; Lohs, A.; Lorenz, A.; Louche, F.; Lubyako, L.; Lumsdaine, A.; Lyssoivan, A.; Maaßberg, H.; Marek, P.; Martens, C.; Marushchenko, N.; Mayer, M.; Mendelevitch, B.; Mertens, Ph.; Mikkelsen, D.; Mishchenko, A.; Missal, B.; Mizuuchi, T.; Modrow, H.; Mönnich, T.; Morizaki, T.; Murakami, S.; Musielok, F.; Nagel, M.; Naujoks, D.; Neilson, H.; Neubauer, O.; Neuner, U.; Nocentini, R.; Noterdaeme, J.-M.; Nührenberg, C.; Obermayer, S.; Offermanns, G.; Oosterbeek, H.; Otte, M.; Panin, A.; Pap, M.; Paquay, S.; Pasch, E.; Peng, X.; Petrov, S.; Pilopp, D.; Pirsch, H.; Plaum, B.; Pompon, F.; Povilaitis, M.; Preinhaelter, J.; Prinz, O.; Purps, F.; Rajna, T.; Récsei, S.; Reiman, A.; Reiter, D.; Remmel, J.; Renard, S.; Rhode, V.; Riemann, J.; Rimkevicius, S.; Riße, K.; Rodatos, A.; Rodin, I.; Romé, M.; Roscher, H.-J.; Rummel, K.; Rummel, Th.; Runov, A.; Ryc, L.; Sachtleben, J.; Samartsev, A.; Sanchez, M.; Sano, F.; Scarabosio, A.; Schmid, M.; Schmitz, H.; Schmitz, O.; Schneider, M.; Schneider, W.; Scheibl, L.; Scholz, M.; Schröder, G.; Schröder, M.; Schruff, J.; Schumacher, H.; Shikhovtsev, I. V.; Shoji, M.; Siegl, G.; Skodzik, J.; Smirnow, M.; Speth, E.; Spong, D. A.; Stadler, R.; Sulek, Z.; Szabó, V.; Szabolics, T.; Szetefi, T.; Szökefalvi-Nagy, Z.; Tereshchenko, A.; Thomsen, H.; Thumm, M.; Timmermann, D.; Tittes, H.; Toi, K.; Tournianski, M.; Toussaint, U. v.; Tretter, J.; Tulipán, S.; Turba, P.; Uhlemann, R.; Urban, J.; Urbonavicius, E.; Urlings, P.; Valet, S.; Van Eester, D.; Van Schoor, M.; Vervier, M.; Viebke, H.; Vilbrandt, R.; Vrancken, M.; Wauters, T.; Weissgerber, M.; Weiß, E.; Weller, A.; Wendorf, J.; Wenzel, U.; Windisch, T.; Winkler, E.; Winkler, M.; Wolowski, J.; Wolters, J.; Wrochna, G.; Xanthopoulos, P.; Yamada, H.; Yokoyama, M.; Zacharias, D.; Zajac, J.; Zangl, G.; Zarnstorff, M.; Zeplien, H.; Zoletnik, S.; Zuin, M.
2013-12-01
The next step in the Wendelstein stellarator line is the large superconducting device Wendelstein 7-X, currently under construction in Greifswald, Germany. Steady-state operation is an intrinsic feature of stellarators, and one key element of the Wendelstein 7-X mission is to demonstrate steady-state operation under plasma conditions relevant for a fusion power plant. Steady-state operation of a fusion device, on the one hand, requires the implementation of special technologies, giving rise to technical challenges during the design, fabrication and assembly of such a device. On the other hand, also the physics development of steady-state operation at high plasma performance poses a challenge and careful preparation. The electron cyclotron resonance heating system, diagnostics, experiment control and data acquisition are prepared for plasma operation lasting 30 min. This requires many new technological approaches for plasma heating and diagnostics as well as new concepts for experiment control and data acquisition.
On the theory of steady-state crystallization with a non-equilibrium mushy layer
NASA Astrophysics Data System (ADS)
Alexandrov, D. V.; Alexandrova, I. V.; Ivanov, A. A.
2016-12-01
Complete analytical solutions of nonlinear equations describing the steady-state directional crystallization of binary melts with a nonequilibrium mushy layer, where the processes of nucleation and growth of crystals occur, are constructed.
Quasi steady-state aerodynamic model development for race vehicle simulations
NASA Astrophysics Data System (ADS)
Mohrfeld-Halterman, J. A.; Uddin, M.
2016-01-01
Presented in this paper is a procedure to develop a high fidelity quasi steady-state aerodynamic model for use in race car vehicle dynamic simulations. Developed to fit quasi steady-state wind tunnel data, the aerodynamic model is regressed against three independent variables: front ground clearance, rear ride height, and yaw angle. An initial dual range model is presented and then further refined to reduce the model complexity while maintaining a high level of predictive accuracy. The model complexity reduction decreases the required amount of wind tunnel data thereby reducing wind tunnel testing time and cost. The quasi steady-state aerodynamic model for the pitch moment degree of freedom is systematically developed in this paper. This same procedure can be extended to the other five aerodynamic degrees of freedom to develop a complete six degree of freedom quasi steady-state aerodynamic model for any vehicle.
Decoding of the sound frequency from the steady-state neural activities in rat auditory cortex.
Shiramatsu, Tomoyo I; Noda, Takahiro; Kanzaki, Ryohei; Takahashi, Hirokazu
2013-01-01
In the auditory cortex, onset activities have been extensively investigated as a cortical representation of sound information such as sound frequency. Yet, less attention has been paid to date to steady-state activities following the onset activities. In this study, we used machine learning to investigate whether steady-state activities in the presence of continuous sounds represent the sound frequency. Sparse Logistic Regression (SLR) decoded the sound frequency from band specific power or phase locking value (PLV) of local field potentials (LFP) from the fourth layer of the auditory cortex of anesthetized rats. Consequently, we found that SLR was able to decode the sound frequency from steady-state neural activities as well as onset activities. This result demonstrates that the steady-state activities contain information about the sound such as sound frequency.
Steady-state existence of passive vector fields under the Kraichnan model.
Arponen, Heikki
2010-03-01
The steady-state existence problem for Kraichnan advected passive vector models is considered for isotropic and anisotropic initial values in arbitrary dimension. The models include the magnetohydrodynamic (MHD) equations, linear pressure model, and linearized Navier-Stokes (LNS) equations. In addition to reproducing the previously known results for the MHD model, we obtain the values of the Kraichnan model roughness parameter xi for which the LNS steady state exists.
Steady-state ab initio laser theory for N-level lasers.
Cerjan, Alexander; Chong, Yidong; Ge, Li; Stone, A Douglas
2012-01-02
We show that Steady-state Ab initio Laser Theory (SALT) can be applied to find the stationary multimode lasing properties of an N-level laser. This is achieved by mapping the N-level rate equations to an effective two-level model of the type solved by the SALT algorithm. This mapping yields excellent agreement with more computationally demanding N-level time domain solutions for the steady state.
Bifurcation analysis of steady-state flows in the lid-driven cavity
NASA Astrophysics Data System (ADS)
Nuriev, A. N.; Egorov, A. G.; Zaitseva, O. N.
2016-12-01
The paper is devoted to the study of the non-uniqueness issues of a steady-state flow in the square lid-driven cavity. A range 0\\lt {Re} \\lt 20000 of Reynolds numbers is considered in which a numerical bifurcation analysis is carried out. The analysis allows us to localize several branches of the steady-state solution and also to investigate their stability.
Rosenblatt, Marcus; Timmer, Jens; Kaschek, Daniel
2016-01-01
Ordinary differential equation models have become a wide-spread approach to analyze dynamical systems and understand underlying mechanisms. Model parameters are often unknown and have to be estimated from experimental data, e.g., by maximum-likelihood estimation. In particular, models of biological systems contain a large number of parameters. To reduce the dimensionality of the parameter space, steady-state information is incorporated in the parameter estimation process. For non-linear models, analytical steady-state calculation typically leads to higher-order polynomial equations for which no closed-form solutions can be obtained. This can be circumvented by solving the steady-state equations for kinetic parameters, which results in a linear equation system with comparatively simple solutions. At the same time multiplicity of steady-state solutions is avoided, which otherwise is problematic for optimization. When solved for kinetic parameters, however, steady-state constraints tend to become negative for particular model specifications, thus, generating new types of optimization problems. Here, we present an algorithm based on graph theory that derives non-negative, analytical steady-state expressions by stepwise removal of cyclic dependencies between dynamical variables. The algorithm avoids multiple steady-state solutions by construction. We show that our method is applicable to most common classes of biochemical reaction networks containing inhibition terms, mass-action and Hill-type kinetic equations. Comparing the performance of parameter estimation for different analytical and numerical methods of incorporating steady-state information, we show that our approach is especially well-tailored to guarantee a high success rate of optimization.
Steady-state entanglement of a Bose-Einstein condensate and a nanomechanical resonator
Asjad, Muhammad; Saif, Farhan
2011-09-15
We analyze the steady-state entanglement between Bose-Einstein condensate trapped inside an optical cavity with a moving end mirror (nanomechanical resonator) driven by a single mode laser. The quantized laser field mediates the interaction between the Bose-Einstein condensate and nanomechanical resonator. In particular, we study the influence of temperature on the entanglement of the coupled system, and note that the steady-state entanglement is fragile with respect to temperature.
Steady-state 2. pi. pulses under conditions of passive locking of laser modes
Komarov, K.P.; Ugozhaev, V.D.
1984-06-01
A theoretical study is made of laser mode locking in the regime of self-induced transparency of a passive filter. It is shown that there is a solution in the form of ultrashort steady-state 2..pi.. pulses. The range of stability of this regime and its characteristics are determined. By way of example, estimates are obtained of parameters of a steady-state pulse emitted by an alexandrite laser with a potassium absorption cell.
The effect of oxygen on denitrification during steady-state growth of Paracoccus halodenitrificans
NASA Technical Reports Server (NTRS)
Hochstein, L. I.; Betlach, M.; Kritikos, G.
1984-01-01
Steady-state cultures of Paracoccus halodenitrificans were grown anaerobically prior to establishing steady states at different concentrations of oxygen. In the absence of oxygen, nitrate-limited cultures produced dinitrogen, and as the oxygen supply increased, these cultures produced nitrous oxide, then nitrite. These changes reflected two phenomena: the inactivation of nitrous oxide reductase by oxygen and the diversion of electrons from nitrite to oxygen.
Rosenblatt, Marcus; Timmer, Jens; Kaschek, Daniel
2016-01-01
Ordinary differential equation models have become a wide-spread approach to analyze dynamical systems and understand underlying mechanisms. Model parameters are often unknown and have to be estimated from experimental data, e.g., by maximum-likelihood estimation. In particular, models of biological systems contain a large number of parameters. To reduce the dimensionality of the parameter space, steady-state information is incorporated in the parameter estimation process. For non-linear models, analytical steady-state calculation typically leads to higher-order polynomial equations for which no closed-form solutions can be obtained. This can be circumvented by solving the steady-state equations for kinetic parameters, which results in a linear equation system with comparatively simple solutions. At the same time multiplicity of steady-state solutions is avoided, which otherwise is problematic for optimization. When solved for kinetic parameters, however, steady-state constraints tend to become negative for particular model specifications, thus, generating new types of optimization problems. Here, we present an algorithm based on graph theory that derives non-negative, analytical steady-state expressions by stepwise removal of cyclic dependencies between dynamical variables. The algorithm avoids multiple steady-state solutions by construction. We show that our method is applicable to most common classes of biochemical reaction networks containing inhibition terms, mass-action and Hill-type kinetic equations. Comparing the performance of parameter estimation for different analytical and numerical methods of incorporating steady-state information, we show that our approach is especially well-tailored to guarantee a high success rate of optimization. PMID:27243005
Steady state effects in a two-pulse diffusion-weighted sequence
Zubkov, Mikhail; Stait-Gardner, Timothy; Price, William S.; Stilbs, Peter
2015-04-21
In conventional nuclear magnetic resonance (NMR) diffusion measurements a significant amount of experimental time is used up by magnetization recovery, serving to prevent the formation of the steady state, as in the latter case the manifestation of diffusion is modulated by multiple applications of the pulse sequence and conventional diffusion coefficient inference procedures are generally not applicable. Here, an analytical expression for diffusion-related effects in a two-pulse NMR experiment (e.g., pulsed-gradient spin echo) in the steady state mode (with repetition times less than the longitudinal relaxation time of the sample) is derived by employing a Fourier series expansion within the solution of the Bloch-Torrey equations. Considerations are given for the transition conditions between the full relaxation and the steady state experiment description. The diffusion coefficient of a polymer solution (polyethylene glycol) is measured by a two-pulse sequence in the full relaxation mode and for a range of repetition times, approaching the rapid steady state experiment. The precision of the fitting employing the presented steady state solution by far exceeds that of the conventional fitting. Additionally, numerical simulations are performed yielding results strongly supporting the proposed description of the NMR diffusion measurements in the steady state.
Steady state multiplicity of two-step biological conversion systems with general kinetics.
Volcke, E I P; Sbarciog, M; Noldus, E J L; De Baets, B; Loccufier, M
2010-12-01
This study analyses the steady state behaviour of biological conversion systems with general kinetics, in which two consecutive reactions are carried out by two groups of micro-organisms. The model considered is a realistic description of wastewater treatment processes. A step-wise procedure is followed to reveal the mechanisms affecting the occurrence of steady states in terms of the process input variables. It is clearly demonstrated how taking into account inhibition effects by simply including additional inhibition terms to the kinetic expressions, a common practice, influences the model's long term behaviour. The overall steady state behaviour of the model has been summarized in easy-to-interpret operating diagrams, depicting the occurrence of steady states in terms of the reactor dilution rate and the influent substrate concentration, with well-defined boundaries between distinct operating regions. This knowledge is crucial for modelers as steady state multiplicity--in the sense that more than one steady state can be reached depending on the initial conditions--may remain undetected during simulation. The obtained results may also serve for experimental design and for model validation based on experimental findings.
Efficient steady-state solution techniques for variably saturated groundwater flow
NASA Astrophysics Data System (ADS)
Farthing, Matthew W.; Kees, Christopher E.; Coffey, Todd S.; Kelley, C. T.; Miller, Cass T.
We consider the simulation of steady-state variably saturated groundwater flow using Richards' equation (RE). The difficulties associated with solving RE numerically are well known. Most discretization approaches for RE lead to nonlinear systems that are large and difficult to solve. The solution of nonlinear systems for steady-state problems can be particularly challenging, since a good initial guess for the steady-state solution is often hard to obtain, and the resulting linear systems may be poorly scaled. Common approaches like Picard iteration or variations of Newton's method have their advantages but perform poorly with standard globalization techniques under certain conditions. Pseudo-transient continuation has been used in computational fluid dynamics for some time to obtain steady-state solutions for problems in which Newton's method with standard line-search strategies fails. Here, we examine the use of pseudo-transient continuation as well as Newton's method combined with standard globalization techniques for steady-state problems in heterogeneous domains. We investigate the methods' performance with direct and preconditioned Krylov iterative linear solvers. We then make recommendations for robust and efficient approaches to obtain steady-state solutions for RE under a range of conditions.
Mass-Radius Spirals for Steady State Families of the Vlasov-Poisson System
NASA Astrophysics Data System (ADS)
Ramming, Tobias; Rein, Gerhard
2017-02-01
We consider spherically symmetric steady states of the Vlasov-Poisson system, which describe equilibrium configurations of galaxies or globular clusters. If the microscopic equation of state, i.e., the dependence of the steady state on the particle energy (and angular momentum) is fixed, a one-parameter family of such states is obtained. In the polytropic case the mass of the state along such a one-parameter family is a monotone function of its radius. We prove that for the King, Woolley-Dickens, and related models this mass-radius relation takes the form of a spiral.
Hong, Changki; Hwang, Jeewon; Cho, Kwang-Hyun; Shin, Insik
2015-01-01
Boolean networks have been widely used to model biological processes lacking detailed kinetic information. Despite their simplicity, Boolean network dynamics can still capture some important features of biological systems such as stable cell phenotypes represented by steady states. For small models, steady states can be determined through exhaustive enumeration of all state transitions. As the number of nodes increases, however, the state space grows exponentially thus making it difficult to find steady states. Over the last several decades, many studies have addressed how to handle such a state space explosion. Recently, increasing attention has been paid to a satisfiability solving algorithm due to its potential scalability to handle large networks. Meanwhile, there still lies a problem in the case of large models with high maximum node connectivity where the satisfiability solving algorithm is known to be computationally intractable. To address the problem, this paper presents a new partitioning-based method that breaks down a given network into smaller subnetworks. Steady states of each subnetworks are identified by independently applying the satisfiability solving algorithm. Then, they are combined to construct the steady states of the overall network. To efficiently apply the satisfiability solving algorithm to each subnetwork, it is crucial to find the best partition of the network. In this paper, we propose a method that divides each subnetwork to be smallest in size and lowest in maximum node connectivity. This minimizes the total cost of finding all steady states in entire subnetworks. The proposed algorithm is compared with others for steady states identification through a number of simulations on both published small models and randomly generated large models with differing maximum node connectivities. The simulation results show that our method can scale up to several hundreds of nodes even for Boolean networks with high maximum node connectivity. The
Hong, Changki; Hwang, Jeewon; Cho, Kwang-Hyun; Shin, Insik
2015-01-01
Boolean networks have been widely used to model biological processes lacking detailed kinetic information. Despite their simplicity, Boolean network dynamics can still capture some important features of biological systems such as stable cell phenotypes represented by steady states. For small models, steady states can be determined through exhaustive enumeration of all state transitions. As the number of nodes increases, however, the state space grows exponentially thus making it difficult to find steady states. Over the last several decades, many studies have addressed how to handle such a state space explosion. Recently, increasing attention has been paid to a satisfiability solving algorithm due to its potential scalability to handle large networks. Meanwhile, there still lies a problem in the case of large models with high maximum node connectivity where the satisfiability solving algorithm is known to be computationally intractable. To address the problem, this paper presents a new partitioning-based method that breaks down a given network into smaller subnetworks. Steady states of each subnetworks are identified by independently applying the satisfiability solving algorithm. Then, they are combined to construct the steady states of the overall network. To efficiently apply the satisfiability solving algorithm to each subnetwork, it is crucial to find the best partition of the network. In this paper, we propose a method that divides each subnetwork to be smallest in size and lowest in maximum node connectivity. This minimizes the total cost of finding all steady states in entire subnetworks. The proposed algorithm is compared with others for steady states identification through a number of simulations on both published small models and randomly generated large models with differing maximum node connectivities. The simulation results show that our method can scale up to several hundreds of nodes even for Boolean networks with high maximum node connectivity. The
ERIC Educational Resources Information Center
Kosman, Daniel J.
2009-01-01
The steady-state is a fundamental aspect of biochemical pathways in cells; indeed, the concept of steady-state is a definition of life itself. In a simple enzyme kinetic scheme, the steady-state condition is easy to define analytically but experimentally often difficult to capture because of its evanescent quality; the initial, constant velocity…
Chirp and Click Evoked Auditory Steady State Responses
2007-11-02
state evoked potentials: A new tool for the accurate assessment of hearing in cochlear implant candidates. Advances in Otorhinolaryngology, 1993. 48...State Responses (ASSR) to 100 µsec clicks and 4 msec cochlear chirps are recorded in adult subjects at repetition rates of 20 to 100 Hz in 10 Hz...differences in the cochlea according to the DeBoer’s cochlear model [14] in order to determine if it will generate better ASSR. We also attempted to
Steady state, erosional continuity, and the topography of landscapes developed in layered rocks
NASA Astrophysics Data System (ADS)
Perne, Matija; Covington, Matthew D.; Thaler, Evan A.; Myre, Joseph M.
2017-01-01
The concept of topographic steady state has substantially informed our understanding of the relationships between landscapes, tectonics, climate, and lithology. In topographic steady state, erosion rates are equal everywhere, and steepness adjusts to enable equal erosion rates in rocks of different strengths. This conceptual model makes an implicit assumption of vertical contacts between different rock types. Here we hypothesize that landscapes in layered rocks will be driven toward a state of erosional continuity, where retreat rates on either side of a contact are equal in a direction parallel to the contact rather than in the vertical direction. For vertical contacts, erosional continuity is the same as topographic steady state, whereas for horizontal contacts it is equivalent to equal rates of horizontal retreat on either side of a rock contact. Using analytical solutions and numerical simulations, we show that erosional continuity predicts the form of flux steady-state landscapes that develop in simulations with horizontally layered rocks. For stream power erosion, the nature of continuity steady state depends on the exponent, n, in the erosion model. For n = 1, the landscape cannot maintain continuity. For cases where n ≠ 1, continuity is maintained, and steepness is a function of erodibility that is predicted by the theory. The landscape in continuity steady state can be quite different from that predicted by topographic steady state. For n < 1 continuity predicts that channels incising subhorizontal layers will be steeper in the weaker rock layers. For subhorizontal layered rocks with different erodibilities, continuity also predicts larger slope contrasts than in topographic steady state. Therefore, the relationship between steepness and erodibility within a sequence of layered rocks is a function of contact dip. For the subhorizontal limit, the history of layers exposed at base level also influences the steepness-erodibility relationship. If uplift rate
2014-01-01
Background A key problem in the analysis of mathematical models of molecular networks is the determination of their steady states. The present paper addresses this problem for Boolean network models, an increasingly popular modeling paradigm for networks lacking detailed kinetic information. For small models, the problem can be solved by exhaustive enumeration of all state transitions. But for larger models this is not feasible, since the size of the phase space grows exponentially with the dimension of the network. The dimension of published models is growing to over 100, so that efficient methods for steady state determination are essential. Several methods have been proposed for large networks, some of them heuristic. While these methods represent a substantial improvement in scalability over exhaustive enumeration, the problem for large networks is still unsolved in general. Results This paper presents an algorithm that consists of two main parts. The first is a graph theoretic reduction of the wiring diagram of the network, while preserving all information about steady states. The second part formulates the determination of all steady states of a Boolean network as a problem of finding all solutions to a system of polynomial equations over the finite number system with two elements. This problem can be solved with existing computer algebra software. This algorithm compares favorably with several existing algorithms for steady state determination. One advantage is that it is not heuristic or reliant on sampling, but rather determines algorithmically and exactly all steady states of a Boolean network. The code for the algorithm, as well as the test suite of benchmark networks, is available upon request from the corresponding author. Conclusions The algorithm presented in this paper reliably determines all steady states of sparse Boolean networks with up to 1000 nodes. The algorithm is effective at analyzing virtually all published models even those of moderate
Development of a High Speed Crowbar for LANSCE
NASA Astrophysics Data System (ADS)
Friedrichs, C.; Lyles, J.; Doub, J. M.
1997-05-01
Each of the four 200 Mhz Final Power Amplifiers (FPAs) in the LANSCE proton linac has its own capacitor bank and crowbar. The dissipation in the 10 ohm crowbar limiting resistor is 67 kW, and oil cooling is used. Our stated upgrade goal was to substantially reduce the limiting resistor dissipation and eliminate the oil cooling. Early tests showed that the fault energy quickly rose to unacceptable levels as the current limiting resistance was reduced. FPA arcs are normally quenched by interrupting the FPA modulator current, and the crowbar waits 10 microseconds for this to occur. The successful upgrade strategy was to replace the 10 ohm resistor with a 3 ohm air cooled resistor and to add a high speed crowbar circuit which operates only if there are simultaneous arcs in the FPA and its modulator. This paper describes the high speed circuit and its interface with the existing crowbar. Test results are also given.
Determination of the Nonequilibrium Steady State Emerging from a Defect
NASA Astrophysics Data System (ADS)
Bertini, Bruno; Fagotti, Maurizio
2016-09-01
We consider the nonequilibrium time evolution of a translationally invariant state under a Hamiltonian with a localized defect. We discern the situations where a light cone spreads out from the defect and separates the system into regions with macroscopically different properties. We identify the light cone and propose a procedure to obtain a (quasi)stationary state describing the late time dynamics of local observables. As an explicit example, we study the time evolution generated by the Hamiltonian of the transverse-field Ising chain with a local defect that cuts the interaction between two sites (a quench of the boundary conditions alongside a global quench). We solve the dynamics exactly and show that the late time properties can be obtained with the general method proposed.
LANSCE Wire Scanner System Prototype: Switchyard Test
Sedillo, James D
2012-04-11
On November 19, 2011, the beam diagnostics team of Los Alamos National Laboratory's LANSCE accelerator facility conducted a test of a prototype wire scanner system for future deployment within the accelerator's switchyard area. The primary focus of this test was to demonstrate the wire scanner control system's ability to extend its functionality beyond acquiring lower energy linac beam profile measurements to acquiring data in the switchyard. This study summarizes the features and performance characteristics of the electronic and mechanical implementation of this system with details focusing on the test results.
Steady state security assessment in deregulated power systems
NASA Astrophysics Data System (ADS)
Manjure, Durgesh Padmakar
Power system operations are undergoing changes, brought about primarily due to deregulation and subsequent restructuring of the power industry. The primary intention of the introduction of deregulation in power systems was to bring about competition and improved customer focus. The underlying motive was increased economic benefit. Present day power system analysis is much different than what it was earlier, essentially due to the transformation of the power industry from being cost-based to one that is price-based and due to open access of transmission networks to the various market participants. Power is now treated as a commodity and is traded in an open market. The resultant interdependence of the technical criteria and the economic considerations has only accentuated the need for accurate analysis in power systems. The main impetus in security analysis studies is on efficient assessment of the post-contingency status of the system, accuracy being of secondary consideration. In most cases, given the time frame involved, it is not feasible to run a complete AC load flow for determining the post-contingency state of the system. Quite often, it is not warranted as well, as an indication of the state of the system is desired rather than the exact quantification of the various state variables. With the inception of deregulation, transmission networks are subjected to a host of multilateral transactions, which would influence physical system quantities like real power flows, security margins and voltage levels. For efficient asset utilization and maximization of the revenue, more often than not, transmission networks are operated under stressed conditions, close to security limits. Therefore, a quantitative assessment of the extent to which each transaction adversely affects the transmission network is required. This needs to be done accurately as the feasibility of the power transactions and subsequent decisions (execution, curtailment, pricing) would depend upon the
Mimicking Nonequilibrium Steady States with Time-Periodic Driving
2016-08-29
balance system can have instantaneous currents equal to the currents in the loop 1 → 3 → 4 → 1 FIG. 2. A concrete example of a NESS for which we build an...definitions of the construction are followed by a concrete application to the example of the four-state system described in Fig. 2. In this example, the NESS...Nevertheless, the tools developed so far might be useful even for constrained systems. We next demonstrate this through a concrete example: kinetic
Reformulation of the Fourier-Bessel steady state mode solver
NASA Astrophysics Data System (ADS)
Gauthier, Robert C.
2016-09-01
The Fourier-Bessel resonator state mode solver is reformulated using Maxwell's field coupled curl equations. The matrix generating expressions are greatly simplified as well as a reduction in the number of pre-computed tables making the technique simpler to implement on a desktop computer. The reformulation maintains the theoretical equivalence of the permittivity and permeability and as such structures containing both electric and magnetic properties can be examined. Computation examples are presented for a surface nanoscale axial photonic resonator and hybrid { ε , μ } quasi-crystal resonator.
Steady States of the Inhomogenous Microwave Irradiated Quantum Hall Gas
NASA Astrophysics Data System (ADS)
Auerbach, Assa; Finkler, Ilya; Halperin, Bertrand; Yacoby, Amir
2005-03-01
To explain the observation of Zero-Resistance states (ZRS) in Microwave irradiated Quantum Hall gases[1], it has been proposed[2] that under appropriate conditions the sample will break into domains of photogenerated fields. In the absence of disorder induced pinning, motion of domain walls results in a ZRS state. In order to treat the effects of long wavelength disorder, we construct a Lyapunov functional for systems with uniform Hall conductivity. We use it to derive stability conditions on the domain structure and to compute the conductance. We show that weak white noise disorder does not destroy the ZRS although it produces current fluctuations. In contrast, separable and correlated disorder pin the domain walls, and produce a finite conductance and a photovoltage as demonstrated by one dimensional, and simple two dimensional, potentials.1. R.G. Mani et.al. Nature, 420, 646 (2002); M.A. Zudov et.al., Phys. Rev. Lett. 90, 046807 (2003).2. A.V. Andreev, I.L. Aleiner, and A.J. Millis, PRL 91, 056803 (2003).
NASA Astrophysics Data System (ADS)
Gedeon, M.; Mallants, D.
2012-04-01
Radionuclide concentration predictions in aquifers play an important role in estimating impact of planned surface disposal of radioactive waste in Belgium, developed by the Belgian Agency for Radioactive Waste and Enriched Fissile Materials (ONDRAF), who also coordinates and leads the corresponding research. Long-term concentration predictions are based on a steady-state flow solution obtained by a cascade of multi-scale models from the catchment to the detailed (site) scale performed in MODFLOW. To test the concept and accuracy of the groundwater flow solution and conservativeness of the concentration predictions obtained therewith, a transient model, considered more realistic, was set up in a sub-domain of the intermediate scale steady-state model. Besides the modelling domain reduction, the transient model was and exact copy of the steady-state model, having the infiltration as the only time-varying parameter. The transient model was run for a twenty-year period, whereas the results were compared to the steady-state results based on infiltration value and observations averaged over the same period. The comparison of the steady-state and transient flow solutions includes the analyses of the goodness of fit, the parameter sensitivities, relative importance of the individual observations and one-percent sensitivity maps. The steady-state and transient flow solutions were subsequently translated into a site-scale transport model, used to predict the radionuclide concentrations in a hypothetical well in the aquifers. The translation of the flow solutions between the models of distinct scales was performed using the Local grid refinement method available in MODFLOW. In the site-scale models, MT3DMS transport simulations were performed to obtain respective concentration predictions in a hypothetical well, situated at 70 meters from the disposal tumuli. The equilibrium concentrations based on a constant source flux achieved using a steady-state solution were then
Simulation of a steady-state integrated human thermal system.
NASA Technical Reports Server (NTRS)
Hsu, F. T.; Fan, L. T.; Hwang, C. L.
1972-01-01
The mathematical model of an integrated human thermal system is formulated. The system consists of an external thermal regulation device on the human body. The purpose of the device (a network of cooling tubes held in contact with the surface of the skin) is to maintain the human body in a state of thermoneutrality. The device is controlled by varying the inlet coolant temperature and coolant mass flow rate. The differential equations of the model are approximated by a set of algebraic equations which result from the application of the explicit forward finite difference method to the differential equations. The integrated human thermal system is simulated for a variety of combinations of the inlet coolant temperature, coolant mass flow rate, and metabolic rates.
Sickle cell disease painful crisis and steady state differentiation by proton magnetic resonance.
Fernández, Adolfo A; Cabal, Carlos A; Lores, Manuel A; Losada, Jorge; Pérez, Enrique R
2009-01-01
The delay time of the Hb S polymerization process was investigated in 63 patients with sickle cell disease during steady state and 10 during painful crisis starting from spin-spin proton magnetic resonance (PMR) time behavior measured at 36 degrees C and during spontaneous deoxygenation. We found a significant decrease of delay time as a result of the crisis (36 +/- 10%) and two well-differentiated ranges of values for each state: 273-354 min for steady state and 166-229 min for crisis with an uncertainty region of 15%. It is possible to use PMR as an objective and quantitative method in order to differentiate both clinical conditions of the sickle cell patient, but a more clear differentiation can be established comparing the delay time (td) value of one patient during crisis with his own td value during steady state.
Cell kinetics of GM-CFC in the steady state
Hagan, M.P.; MacVittie, T.J.; Dodgen, D.P.
1985-07-01
The kinetics of cell turnover for myeloid/monocyte cells that form colonies in agar (GM-CFC) were measured through the progressive increase in their sensitivity to 313-nm light during a period of cell labeling with BrdCyd. Two components of cell killing with distinctly separate labeling kinetics revealed both the presence of two generations within the GM-CFC compartment and the properties of the kinetics of the precursors of the GM-CFC. These precursors of the GM-CFC were not assayable in a routine GM-CFC assay when pregnant mouse uterus extract and mouse L-cell-conditioned medium were used to stimulate colony formation but were revealed by the labeling kinetics of the assayable GM-CFC. Further, these precursor cells appeared to enter the assayable GM-CFC population from a noncycling state. This was evidenced by the failure of the majority of these cells to incorporate BrdCyd during five days of infusion. The half-time for cell turnover within this precursor compartment was measured to be approximately 5.5 days. Further, these normally noncycling cells proliferated rapidly in response to endotoxin. High-proliferative-potential colony-forming cells (HPP-CFC) were tested as a candidate for this precursor population. The results of the determination of the kinetics for these cells showed that the HPP-CFC exist largely in a Go state, existing at an average rate of once every four days. The slow turnover time for these cells and their response to endotoxin challenge are consistent with a close relationship between the HPP-CFC and the Go pool of cells that is the direct precursor of the GM-CFC.
A quaternionic map for the steady states of the Heisenberg spin-chain
NASA Astrophysics Data System (ADS)
Mehta, Mitaxi P.; Dutta, Souvik; Tiwari, Shubhanshu
2014-01-01
We show that the steady states of the classical Heisenberg XXX spin-chain in an external magnetic field can be found by iterations of a quaternionic map. A restricted model, e.g., the xy spin-chain is known to have spatially chaotic steady states and the phase space occupied by these chaotic states is known to go through discrete changes as the field strength is varied. The same phenomenon is studied for the xxx spin-chain. It is seen that in this model the phase space volume varies smoothly with the external field.
Archelas, Alain; Zhao, Wei; Faure, Bruno; Iacazio, Gilles; Kotik, Michael
2016-02-01
A detailed kinetic study based on steady-state and pre-steady-state measurements is described for the highly enantioselective epoxide hydrolase Kau2. The enzyme, which is a member of the α/β-hydrolase fold family, preferentially reacts with the (S,S)-enantiomer of trans-stilbene oxide (TSO) with an E value of ∼200. The enzyme follows a classical two-step catalytic mechanism with formation of an alkyl-enzyme intermediate in the first step and hydrolysis of this intermediate in a rate-limiting second step. Tryptophan fluorescence quenching during TSO conversion appears to correlate with alkylation of the enzyme. The steady-state data are consistent with (S,S) and (R,R)-TSO being two competing substrates with marked differences in k(cat) and K(M) values. The high enantiopreference of the epoxide hydrolase is best explained by pronounced differences in the second-order alkylation rate constant (k2/K(S)) and the alkyl-enzyme hydrolysis rate k3 between the (S,S) and (R,R)-enantiomers of TSO. Our data suggest that during conversion of (S,S)-TSO the two active site tyrosines, Tyr(157) and Tyr(259), serve mainly as electrophilic catalysts in the alkylation half-reaction, polarizing the oxirane oxygen of the bound epoxide through hydrogen bond formation, however, without fully donating their hydrogens to the forming alkyl-enzyme intermediate.
Synchronous machine steady-state stability analysis using an artificial neural network
Chen, C.R.; Hsu, Y.Y. . Dept. of Electrical Engineering)
1991-03-01
A new type of artificial neural network is proposed for the steady-state stability analysis of a synchronous generator. In the developed artificial neutral network, those system variables which play an important role in steady-state stability such as generator outputs and power system stabilizer parameters are employed as the inputs. The output of the neural net provides the information on steady-state stability. Once the connection weights of the neural network have been learned using a set of training data derived off-line, the neural net can be applied to analyze the steady-state stability of the system time. To demonstrate the effectiveness of the proposed neural net, steady-state stability analysis is performed on a synchronous generator connected to a large power system. It is found that the proposed neural net requires much less training time than the multilayer feedforward network with backpropagation-momentum learning algorithm. It is also concluded from the test results that correct stability assessment can be achieved by the neural network.
Perception of steady-state vowels and vowelless syllables by adults and children
NASA Astrophysics Data System (ADS)
Nittrouer, Susan
2005-04-01
Vowels can be produced as long, isolated, and steady-state, but that is not how they are found in natural speech. Instead natural speech consists of almost continuously changing (i.e., dynamic) acoustic forms from which mature listeners recover underlying phonetic form. Some theories suggest that children need steady-state information to recognize vowels (and so learn vowel systems), even though that information is sparse in natural speech. The current study examined whether young children can recover vowel targets from dynamic forms, or whether they need steady-state information. Vowel recognition was measured for adults and children (3, 5, and 7 years) for natural productions of /dæd/, /dUd/ /æ/, /U/ edited to make six stimulus sets: three dynamic (whole syllables; syllables with middle 50-percent replaced by cough; syllables with all but the first and last three pitch periods replaced by cough), and three steady-state (natural, isolated vowels; reiterated pitch periods from those vowels; reiterated pitch periods from the syllables). Adults scored nearly perfectly on all but first/last three pitch period stimuli. Children performed nearly perfectly only when the entire syllable was heard, and performed similarly (near 80%) for all other stimuli. Consequently, children need dynamic forms to perceive vowels; steady-state forms are not preferred.
A stability analysis of the power-law steady state of marine size spectra.
Datta, Samik; Delius, Gustav W; Law, Richard; Plank, Michael J
2011-10-01
This paper investigates the stability of the power-law steady state often observed in marine ecosystems. Three dynamical systems are considered, describing the abundance of organisms as a function of body mass and time: a "jump-growth" equation, a first order approximation which is the widely used McKendrick-von Foerster equation, and a second order approximation which is the McKendrick-von Foerster equation with a diffusion term. All of these yield a power-law steady state. We derive, for the first time, the eigenvalue spectrum for the linearised evolution operator, under certain constraints on the parameters. This provides new knowledge of the stability properties of the power-law steady state. It is shown analytically that the steady state of the McKendrick-von Foerster equation without the diffusion term is always unstable. Furthermore, numerical plots show that eigenvalue spectra of the McKendrick-von Foerster equation with diffusion give a good approximation to those of the jump-growth equation. The steady state is more likely to be stable with a low preferred predator:prey mass ratio, a large diet breadth and a high feeding efficiency. The effects of demographic stochasticity are also investigated and it is concluded that these are likely to be small in real systems.
Diehl, S; Zambrano, J; Carlsson, B
2016-01-01
A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration.
Halász, Adám M; Lai, Hong-Jian; McCabe Pryor, Meghan; Radhakrishnan, Krishnan; Edwards, Jeremy S
2013-01-01
True steady states are a rare occurrence in living organisms, yet their knowledge is essential for quasi-steady-state approximations, multistability analysis, and other important tools in the investigation of chemical reaction networks (CRN) used to describe molecular processes on the cellular level. Here, we present an approach that can provide closed form steady-state solutions to complex systems, resulting from CRN with binary reactions and mass-action rate laws. We map the nonlinear algebraic problem of finding steady states onto a linear problem in a higher-dimensional space. We show that the linearized version of the steady-state equations obeys the linear conservation laws of the original CRN. We identify two classes of problems for which complete, minimally parameterized solutions may be obtained using only the machinery of linear systems and a judicious choice of the variables used as free parameters. We exemplify our method, providing explicit formulae, on CRN describing signal initiation of two important types of RTK receptor-ligand systems, VEGF and EGF-ErbB1.
Analytical Solution of Steady State Equations for Chemical Reaction Networks with Bilinear Rate Laws
Halász, Ádám M.; Lai, Hong-Jian; McCabe, Meghan M.; Radhakrishnan, Krishnan; Edwards, Jeremy S.
2014-01-01
True steady states are a rare occurrence in living organisms, yet their knowledge is essential for quasi-steady state approximations, multistability analysis, and other important tools in the investigation of chemical reaction networks (CRN) used to describe molecular processes on the cellular level. Here we present an approach that can provide closed form steady-state solutions to complex systems, resulting from CRN with binary reactions and mass-action rate laws. We map the nonlinear algebraic problem of finding steady states onto a linear problem in a higher dimensional space. We show that the linearized version of the steady state equations obeys the linear conservation laws of the original CRN. We identify two classes of problems for which complete, minimally parameterized solutions may be obtained using only the machinery of linear systems and a judicious choice of the variables used as free parameters. We exemplify our method, providing explicit formulae, on CRN describing signal initiation of two important types of RTK receptor-ligand systems, VEGF and EGF-ErbB1. PMID:24334389
Mass transport in salt repositories: Steady-state transport through interbeds
Hwang, Y.; Lee, W.W.-L.; Chambre, P.L.; Pigford, T.H. . Dept. of Nuclear Engineering)
1989-03-01
Salt has long been a candidate for geologic disposal of nuclear waste. Because salt is extremely soluble in water, the existence of rock salt in the ground atest to the long-term stability of the salt. Both bedded salt and salt domes have been considered for nuclear waste disposal in the United States and Europe. While the salt is known to be quite pure in salt domes, bedded salt is interlaced with beds of sediments. Traditionally rock salt has not been considered water-conducting, but sediments layers would be classical porous media, capable of conducting water. Therefore there is interest in determining whether interbeds in bedded salt constitute pathway for radionuclide migration. In this report we consider steady-state migration of radionuclides from a single waste cylinder into a single interbed. Two approaches are used. In 1982 Neretnieks proposed an approach for calculating the steady-state transport of oxidants to a copper container. We have adapted that approach for calculating steady-state radionuclide migration away from the waste package, as a first approximation. We have also analyzed the problem of time-dependent radionuclide diffusion from a container through a backfill layer into a fracture, and we used the steady-state solution from that problem for comparison. Section 2 gives a brief summary of the geology of interbeds in bedded salt. Section 3 presents the mass transfer resistances approach of Neretnieks, summarizing the formulation and giving numerical illustrations of the steady-state two-dimensional diffusion analysis. Section 4 gives a brief statement of the steady-state result from a related analysis. Conclusions are stated in Section 5. 13 refs., 5 figs., 2 tabs.
Steady-state distributions of probability fluxes on complex networks
NASA Astrophysics Data System (ADS)
Chełminiak, Przemysław; Kurzyński, Michał
2017-02-01
We consider a simple model of the Markovian stochastic dynamics on complex networks to examine the statistical properties of the probability fluxes. The additional transition, called hereafter a gate, powered by the external constant force breaks a detailed balance in the network. We argue, using a theoretical approach and numerical simulations, that the stationary distributions of the probability fluxes emergent under such conditions converge to the Gaussian distribution. By virtue of the stationary fluctuation theorem, its standard deviation depends directly on the square root of the mean flux. In turn, the nonlinear relation between the mean flux and the external force, which provides the key result of the present study, allows us to calculate the two parameters that entirely characterize the Gaussian distribution of the probability fluxes both close to as well as far from the equilibrium state. Also, the other effects that modify these parameters, such as the addition of shortcuts to the tree-like network, the extension and configuration of the gate and a change in the network size studied by means of computer simulations are widely discussed in terms of the rigorous theoretical predictions.
Simulation of a steady-state integrated human thermal system.
NASA Technical Reports Server (NTRS)
Hsu, F. T.; Fan, L. T.; Hwang, C. L.
1972-01-01
The mathematical model of an integrated human thermal system is formulated. The system consists of an external thermal regulation device on the human body. The purpose of the device (a network of cooling tubes held in contact with the surface of the skin) is to maintain the human body in a state of thermoneutrality. The device is controlled by varying the inlet coolant temperature and coolant mass flow rate. The differential equations of the model are approximated by a set of algebraic equations which result from the application of the explicit forward finite difference method to the differential equations. The integrated human thermal system is simulated for a variety of combinations of the inlet coolant temperature, coolant mass flow rate, and metabolic rates. Two specific cases are considered: (1) the external thermal regulation device is placed only on the head and (2) the devices are placed on the head and the torso. The results of the simulation indicate that when the human body is exposed to hot environment, thermoneutrality can be attained by localized cooling if the operating variables of the external regulation device(s) are properly controlled.
Periodically driven Kondo impurity in nonequilibrium steady states
NASA Astrophysics Data System (ADS)
Iwahori, Koudai; Kawakami, Norio
2016-12-01
We study the nonequilibrium dynamics of a periodically driven anisotropic Kondo impurity model. The periodic time dependence is introduced for a local magnetic field which couples to the impurity spin and also for an in-plane exchange interaction. We obtain the exact results on the time evolution for arbitrary periodic time dependence at the special point in the parameter space known as the Toulouse limit. We first consider a specific case where the local magnetic field is periodically switched on and off. When the driving period is much shorter than the inverse of the Kondo temperature, an intriguing oscillating behavior (resonance phenomenon) emerges in the time average of the impurity spin polarization with increasing the local magnetic field intensity. By taking the high-frequency limit of the external driving, we elucidate that the system recovers the translational invariance in time and can be described by a mixture of the zero-temperature and infinite-temperature properties. In certain cases, the system is governed by either zero-temperature or infinite-temperature properties and, therefore, can be properly described by the corresponding equilibrium state.
Current Pressure Transducer Application of Model-based Prognostics Using Steady State Conditions
NASA Technical Reports Server (NTRS)
Teubert, Christopher; Daigle, Matthew J.
2014-01-01
Prognostics is the process of predicting a system's future states, health degradation/wear, and remaining useful life (RUL). This information plays an important role in preventing failure, reducing downtime, scheduling maintenance, and improving system utility. Prognostics relies heavily on wear estimation. In some components, the sensors used to estimate wear may not be fast enough to capture brief transient states that are indicative of wear. For this reason it is beneficial to be capable of detecting and estimating the extent of component wear using steady-state measurements. This paper details a method for estimating component wear using steady-state measurements, describes how this is used to predict future states, and presents a case study of a current/pressure (I/P) Transducer. I/P Transducer nominal and off-nominal behaviors are characterized using a physics-based model, and validated against expected and observed component behavior. This model is used to map observed steady-state responses to corresponding fault parameter values in the form of a lookup table. This method was chosen because of its fast, efficient nature, and its ability to be applied to both linear and non-linear systems. Using measurements of the steady state output, and the lookup table, wear is estimated. A regression is used to estimate the wear propagation parameter and characterize the damage progression function, which are used to predict future states and the remaining useful life of the system.
Steady State Convection within Medium-size Icy Satellites
NASA Astrophysics Data System (ADS)
Leliwa-Kopystynski, J.; Czechowski, L.
2000-10-01
We consider the satellites of the size range from Mimas or Protheus (radii 200 km) to Titania (790 km). The lower limit is that of the smallest sphere-like bodies. The upper limit is determined by requirement that no phase transitions occurs inside the body or these transitions are only of marginal significance. Therefore, the considered bodies could be 6 satellites of Saturn, 5 of Uranus, Protheus, and Charon. Since Miranda is probably a re-accretion product and density of Protheus is unknown therefore our class of satellites contains 11 globes in total. Their densities are known and therefore the mass ratio rock/total and radioactive heat production can be estimated quite well. Two extreme models of the satellites are considered: non-differentiated (homogeneous) and fully differentiated with rocky core and icy mantle. For the first model there is a uniform distributions of radioactive sources and the convection can develop within the whole globe. For the second case, the radioactivity determines the heat flux through the boundary between rocky core and icy mantle; in this case the possibilities of convection are discussed within the icy mantle. Axially symmetric convection is considered. The model is based on the equations: Navier-Stokes, thermal conductivity, mass continuity, and on the equation of state. They involved a large set of parameters of which the viscosity is the least known and it is strongly dependent on temperature. Written in dimensionless form for constant viscosity the equations have only one parameter, the Rayleigh number Ra. Set of solutions, for different Ra, and for constant viscosity or for temperature dependent viscosity are presented. The solutions, when converted into dimensional form, are applied for interpretation of particular tectonic features on the icy satellites (e.g. Samarkand Sulci on Enceladus and Ithaca Chasma on Tethys). Correlation between tectonic features and far-near sides orientation is expected.
Joseph, David; Schobelock, Michael J; Riesenberg, Robert R; Vince, Bradley D; Webster, Lynn R; Adeniji, Abidemi; Elgadi, Mabrouk; Huang, Fenglei
2015-01-01
The effects of steady-state faldaprevir on the safety, pharmacokinetics, and pharmacodynamics of steady-state methadone and buprenorphine-naloxone were assessed in 34 healthy male and female subjects receiving stable addiction management therapy. Subjects continued receiving a stable oral dose of either methadone (up to a maximum dose of 180 mg per day) or buprenorphine-naloxone (up to a maximum dose of 24 mg-6 mg per day) and also received oral faldaprevir (240 mg) once daily (QD) for 8 days following a 480-mg loading dose. Serial blood samples were taken for pharmacokinetic analysis. The pharmacodynamics of the opioid maintenance regimens were evaluated by the objective and subjective opioid withdrawal scales. Coadministration of faldaprevir with methadone or buprenorphine-naloxone resulted in geometric mean ratios for the steady-state area under the concentration-time curve from 0 to 24 h (AUC(0-24,ss)), the steady-state maximum concentration of the drug in plasma (C(max,ss)), and the steady-state concentration of the drug in plasma at 24 h (C(24,ss)) of 0.92 to 1.18 for (R)-methadone, (S)-methadone, buprenorphine, norbuprenorphine, and naloxone, with 90% confidence intervals including, or very close to including, 1.00 (no effect), suggesting a limited overall effect of faldaprevir. Although individual data showed moderate variability in the exposures between subjects and treatments, there was no evidence of symptoms of opiate overdose or withdrawal either during the coadministration of faldaprevir with methadone or buprenorphine-naloxone or after faldaprevir dosing was stopped. Similar faldaprevir exposures were observed in the methadone- and buprenorphine-naloxone-treated subjects. In conclusion, faldaprevir at 240 mg QD can be coadministered with methadone or buprenorphine-naloxone without dose adjustment, although given the relatively narrow therapeutic windows of these agents, monitoring for opiate overdose and withdrawal may still be appropriate. (This
X-ray spectral analysis of the steady states of GRS 1915+105
NASA Astrophysics Data System (ADS)
Peris, Charith; Remillard, Ronald A.; Steiner, James F.; Dil Vrtilek, Saeqa; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy G.
2016-04-01
Of the black hole binaries (BHBs) discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner disk radius, remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion 80 % of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results combine to suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical BHBs.
Lansce Wire Scanning Diagnostics Device Mechanical Design
Rodriguez Esparza, Sergio; Batygin, Yuri K.; Gilpatrick, John D.; Gruchalla, Michael E.; Maestas, Alfred J.; Pillai, Chandra; Raybun, Joseph L.; Sattler, F. D.; Sedillo, James Daniel; Smith, Brian G.
2011-01-01
The Accelerator Operations & Technology Division at Los Alamos National Laboratory operates a linear particle accelerator which utilizes 110 wire scanning diagnostics devices to gain position and intensity information of the proton beam. In the upcoming LANSCE improvements, 51 of these wire scanners are to be replaced with a new design, up-to-date technology and off-the-shelf components. This document outlines the requirements for the mechanical design of the LANSCE wire scanner and presents the recently developed linac wire scanner prototype. Additionally, this document presents the design modifications that have been implemented into the fabrication and assembly of this first linac wire scanner prototype. Also, this document will present the design for the second, third, and fourth wire scanner prototypes being developed. Prototypes 2 and 3 belong to a different section of the particle accelerator and therefore have slightly different design specifications. Prototype 4 is a modification of a previously used wire scanner in our facility. Lastly, the paper concludes with a plan for future work on the wire scanner development.
LANSCE wire scanning diagnostics device mechanical design
Rodriguez Esparza, Sergio
2010-01-01
The Los Alamos Neutron Science Center (LANSCE) is one of the major experimental science facilities at the Los Alamos National Laboratory (LANL). The core of LANSCE's work lies in the operation of a powerful linear accelerator, which accelerates protons up to 84% the speed oflight. These protons are used for a variety of purposes, including materials testing, weapons research and isotopes production. To assist in guiding the proton beam, a series of over one hundred wire scanners are used to measure the beam profile at various locations along the half-mile length of the particle accelerator. A wire scanner is an electro-mechanical device that moves a set of wires through a particle beam and measures the secondary emissions from the resulting beam-wire interaction to obtain beam intensity information. When supplemented with data from a position sensor, this information is used to determine the cross-sectional profile of the beam. This measurement allows beam operators to adjust parameters such as acceleration, beam steering, and focus to ensure that the beam reaches its destination as effectively as possible. Some of the current wire scanners are nearly forty years old and are becoming obsolete. The problem with current wire scanners comes in the difficulty of maintenance and reliability. The designs of these wire scanners vary making it difficult to keep spare parts that would work on all designs. Also many of the components are custom built or out-dated technology and are no longer in production.
Wang, Qian; Li, Bincheng
2015-09-28
Spatially resolved steady-state photocarrier radiometric (PCR) imaging technique is developed to characterize the electronic transport properties of silicon wafers. Based on a nonlinear PCR theory, simulations are performed to investigate the effects of electronic transport parameters (the carrier lifetime, the carrier diffusion coefficient, and the front surface recombination velocity) on the steady-state PCR intensity profiles. The electronic transport parameters of an n-type silicon wafer are simultaneously determined by fitting the measured steady-state PCR intensity profiles to the three-dimensional nonlinear PCR model. The determined transport parameters are in good agreement with the results obtained by the conventional modulated PCR technique with multiple pump beam radii.
The steady-state visual evoked potential in vision research: A review
Norcia, Anthony M.; Appelbaum, L. Gregory; Ales, Justin M.; Cottereau, Benoit R.; Rossion, Bruno
2015-01-01
Periodic visual stimulation and analysis of the resulting steady-state visual evoked potentials were first introduced over 80 years ago as a means to study visual sensation and perception. From the first single-channel recording of responses to modulated light to the present use of sophisticated digital displays composed of complex visual stimuli and high-density recording arrays, steady-state methods have been applied in a broad range of scientific and applied settings.The purpose of this article is to describe the fundamental stimulation paradigms for steady-state visual evoked potentials and to illustrate these principles through research findings across a range of applications in vision science. PMID:26024451
Mechanism of Non-Steady State Dissolution of Goethite in the Presence of Siderophores
NASA Astrophysics Data System (ADS)
Reichard, P. U.; Kretzschmar, R.; Kraemer, S. M.
2003-12-01
Iron is an essential micronutrient for almost all known organisms. Bacteria, fungi, and graminaceous plants are capable of exuding siderophores as part of an iron acquisition strategy. The production of these strong iron chelating ligands is induced by iron limited conditions. Grasses under iron stress, for example, exude phytosiderophores into the rhizosphere in a special diurnal rhythm (Roemheld and Marschner 1986). A few hours after sunrise the exudation starts, culminates around noon and is shut down again until about 4 hours after noon. The phytosiderophores diffuse into the rhizosphere (Marschner et al. 1986) and are passively back transported to the plants by advective flow induced by high transpiration around noon. Despite a fairly short residence time of the phytosiderophores in the rhizosphere, it is a very effective strategy for iron acquisition. To investigate the effect of such pulse inputs of siderophores on iron acquisition, we studied the dissolution mechanism of goethite (alpha-FeOOH), a mineral phase common in soils, under non-steady state conditions. In consideration of the chemical complexity of the rhizosphere, we also investigated the effect of other organic ligands commonly found in the rhizosphere (e. g. oxalate) on the dissolution kinetics. The dissolution experiments were conducted in batch reactors with a constant goethite solids concentration of 2.5 g/l, an ionic strength of 0.01 M, a pH of 6 and 100 microM oxalate. To induce non-steady state conditions, 3 mM phytosiderophores were added to a batch after the goethite-oxalate suspension reacted for a certain time period. Before the siderophore was added to the goethite-oxalate suspension, no dissolution of iron was observed. But, with the addition of the siderophore, a high rate was observed for the iron mobilization under these non-steady state conditions that subsequently was followed by a slow steady state dissolution rate. The results of these non-steady state experiments are very
Exact steady state manifold of a boundary driven spin-1 Lai-Sutherland chain
NASA Astrophysics Data System (ADS)
Ilievski, Enej; Prosen, Tomaž
2014-05-01
We present an explicit construction of a family of steady state density matrices for an open integrable spin-1 chain with bilinear and biquadratic interactions, also known as the Lai-Sutherland model, driven far from equilibrium by means of two oppositely polarizing Markovian dissipation channels localized at the boundary. The steady state solution exhibits n+1 fold degeneracy, for a chain of length n, due to existence of (strong) Liouvillian U(1) symmetry. The latter can be exploited to introduce a chemical potential and define a grand canonical nonequilibrium steady state ensemble. The matrix product form of the solution entails an infinitely-dimensional representation of a non-trivial Lie algebra (semidirect product of sl2 and a non-nilpotent radical) and hints to a novel Yang-Baxter integrability structure.
Kitazumi, Yuki; Hamamoto, Katsumi; Noda, Tatsuo; Shirai, Osamu; Kano, Kenji
2015-01-01
The fabrication of ultrathin-ring electrodes with a diameter of 2 mm and a thickness of 100 nm is established. The ultrathin-ring electrodes provide a large density of pseudo-steady-state currents, and realize pseudo-steady-state amperometry under quiescent conditions without a Faraday cage. Under the limiting current conditions, the current response at the ultrathin-ring electrode can be well explained by the theory of the microband electrode response. Cyclic voltammograms at the ultrathin-ring electrode show sigmoidal characteristics with some hysteresis. Numerical simulation reveals that the hysteresis can be ascribed to the time-dependence of pseudo-steady-state current. The performance of amperometry with the ultrathin-ring electrode has been verified in its application to redox enzyme kinetic measurements.
Steady-state solutions of a diffusive energy-balance climate model and their stability
NASA Technical Reports Server (NTRS)
Ghil, M.
1975-01-01
A diffusive energy-balance climate model, governed by a nonlinear parabolic partial differential equation, was studied. Three positive steady-state solutions of this equation are found; they correspond to three possible climates of our planet: an interglacial (nearly identical to the present climate), a glacial, and a completely ice-covered earth. Models similar to the main one are considered, and the number of their steady states was determined. All the models have albedo continuously varying with latitude and temperature, and entirely diffusive horizontal heat transfer. The stability under small perturbations of the main model's climates was investigated. A stability criterion is derived, and its application shows that the present climate and the deep freeze are stable, whereas the model's glacial is unstable. The dependence was examined of the number of steady states and of their stability on the average solar radiation.
Current Control in ITER Steady State Plasmas With Neutral Beam Steering
R.V. Budny
2009-09-10
Predictions of quasi steady state DT plasmas in ITER are generated using the PTRANSP code. The plasma temperatures, densities, boundary shape, and total current (9 - 10 MA) anticipated for ITER steady state plasmas are specified. Current drive by negative ion neutral beam injection, lower-hybrid, and electron cyclotron resonance are calculated. Four modes of operation with different combinations of current drive are studied. For each mode, scans with the NNBI aimed at differing heights in the plasma are performed to study effects of current control on the q profile. The timeevolution of the currents and q are calculated to evaluate long duration transients. Quasi steady state, strongly reversed q profiles are predicted for some beam injection angles if the current drive and bootstrap currents are sufficiently large.
Exact Nonequilibrium Steady State of a Strongly Driven Open XXZ Chain
NASA Astrophysics Data System (ADS)
Prosen, Tomaž
2011-09-01
An exact and explicit ladder-tensor-network ansatz is presented for the nonequilibrium steady state of an anisotropic Heisenberg XXZ spin-1/2 chain which is driven far from equilibrium with a pair of Lindblad operators acting on the edges of the chain only. We show that the steady-state density operator of a finite system of size n is—apart from a normalization constant—a polynomial of degree 2n-2 in the coupling constant. Efficient computation of physical observables is facilitated in terms of a transfer operator reminiscent of a classical Markov process. In the isotropic case we find cosine spin profiles, 1/n2 scaling of the spin current, and long-range correlations in the steady state. This is a fully nonperturbative extension of a recent result [Phys. Rev. Lett. 106, 217206 (2011)PRLTAO0031-900710.1103/PhysRevLett.106.217206].
Foster, Carl; Farland, Courtney V.; Guidotti, Flavia; Harbin, Michelle; Roberts, Brianna; Schuette, Jeff; Tuuri, Andrew; Doberstein, Scott T.; Porcari, John P.
2015-01-01
High intensity interval training (HIIT) has become an increasingly popular form of exercise due to its potentially large effects on exercise capacity and small time requirement. This study compared the effects of two HIIT protocols vs steady-state training on aerobic and anaerobic capacity following 8-weeks of training. Fifty-five untrained college-aged subjects were randomly assigned to three training groups (3x weekly). Steady-state (n = 19) exercised (cycle ergometer) 20 minutes at 90% of ventilatory threshold (VT). Tabata (n = 21) completed eight intervals of 20s at 170% VO2max/10s rest. Meyer (n = 15) completed 13 sets of 30s (20 min) @ 100% PVO2 max/ 60s recovery, average PO = 90% VT. Each subject did 24 training sessions during 8 weeks. Results: There were significant (p < 0.05) increases in VO2max (+19, +18 and +18%) and PPO (+17, +24 and +14%) for each training group, as well as significant increases in peak (+8, + 9 and +5%) & mean (+4, +7 and +6%) power during Wingate testing, but no significant differences between groups. Measures of the enjoyment of the training program indicated that the Tabata protocol was significantly less enjoyable (p < 0.05) than the steady state and Meyer protocols, and that the enjoyment of all protocols declined (p < 0.05) across the duration of the study. The results suggest that although HIIT protocols are time efficient, they are not superior to conventional exercise training in sedentary young adults. Key points Steady state training equivalent to HIIT in untrained students Mild interval training presents very similar physiologic challenge compared to steady state training HIIT (particularly very high intensity variants were less enjoyable than steady state or mild interval training Enjoyment of training decreases across the course of an 8 week experimental training program PMID:26664271
Steady-state evoked potentials possibilities for mental-state estimation
NASA Technical Reports Server (NTRS)
Junker, Andrew M.; Schnurer, John H.; Ingle, David F.; Downey, Craig W.
1988-01-01
The use of the human steady-state evoked potential (SSEP) as a possible measure of mental-state estimation is explored. A method for evoking a visual response to a sum-of-ten sine waves is presented. This approach provides simultaneous multiple frequency measurements of the human EEG to the evoking stimulus in terms of describing functions (gain and phase) and remnant spectra. Ways in which these quantities vary with the addition of performance tasks (manual tracking, grammatical reasoning, and decision making) are presented. Models of the describing function measures can be formulated using systems engineering technology. Relationships between model parameters and performance scores during manual tracking are discussed. Problems of unresponsiveness and lack of repeatability of subject responses are addressed in terms of a need for loop closure of the SSEP. A technique to achieve loop closure using a lock-in amplifier approach is presented. Results of a study designed to test the effectiveness of using feedback to consciously connect humans to their evoked response are presented. Findings indicate that conscious control of EEG is possible. Implications of these results in terms of secondary tasks for mental-state estimation and brain actuated control are addressed.
SUPERENERGY-2: a multiassembly, steady-state computer code for LMFBR core thermal-hydraulic analysis
Basehore, K.L.; Todreas, N.E.
1980-08-01
Core thermal-hydraulic design and performance analyses for Liquid Metal Fast Breeder Reactors (LMFBRs) require repeated detailed multiassembly calculations to determine radial temperature profiles and subchannel outlet temperatures for various core configurations and subassembly structural analyses. At steady-state, detailed core-wide temperature profiles are required for core restraint calculations and subassembly structural analysis. In addition, sodium outlet temperatures are routinely needed for each reactor operating cycle. The SUPERENERGY-2 thermal-hydraulic code was designed specifically to meet these designer needs. It is applicable only to steady-state, forced-convection flow in LMFBR core geometries.
S3C: EBT Steady-State Shooting code description and user's guide
Downum, W.B.
1983-09-01
The Oak Ridge National Laboratory (ORNL) one-dimensional (1-D) Steady-State Shooting code (S3C) for ELMO Bumpy Torus (EBT) plasmas is described. Benchmark calculations finding the steady-state density and electron and ion temperature profiles for a known neutral density profile and known external energy sources are carried out. Good agreement is obtained with results from the ORNL Radially Resolved Time Dependent 1-D Transport code for an EBT-Q type reactor. The program logic is described, along with the physics models in each code block and the variable names used. Sample input and output files are listed, along with the main code.
Steady-state creep of complexly reinforced shallow metal-composite shells
NASA Astrophysics Data System (ADS)
Yankovskii, A. P.
2010-05-01
The problem of deformation of shallow shells of variable thickness reinforced with fibers of constant cross section, whose all phases operate under the conditions of steady-state creep, is formulated. The system of resolving equations and the corresponding boundary conditions are analyzed, and the procedure for solving this problem is developed. A way of approximate solution of such problems in the case of transient creep is indicated. The particular calculations performed show that the compliance of thin-walled structures, under the conditions of steady-state creep, greatly depends on the structure of reinforcement.
Wavenumber selection for single-wave steady states in a nonlinear baroclinic system
NASA Technical Reports Server (NTRS)
Weng, H.-Y.; Barcilon, A.
1988-01-01
The principles involved in the selection of a wavenumber for single-wave steady states are examined numerically and analytically in the framework of an Eady-type model with uneven Ekman dissipation. The process of selection involves the determination of the preferred wavenumber for a given parameter setting in the nonlinear system by testing the stability of steady single-wave states in a triad with wavenumbers n(0) - 1, n(0), and n(0) + 1, where n(0) may change successively in the selection procedure. In a given triad for a given parameter setting, the preferred wave is the wave with the nonlinear Eady angle that is last to vanish.
Non-equilibrium steady states: fluctuations and large deviations of the density and of the current
NASA Astrophysics Data System (ADS)
Derrida, Bernard
2007-07-01
These lecture notes give a short review of methods such as the matrix ansatz, the additivity principle or the macroscopic fluctuation theory, developed recently in the theory of non-equilibrium phenomena. They show how these methods allow us to calculate the fluctuations and large deviations of the density and the current in non-equilibrium steady states of systems like exclusion processes. The properties of these fluctuations and large deviation functions in non-equilibrium steady states (for example, non-Gaussian fluctuations of density or non-convexity of the large deviation function which generalizes the notion of free energy) are compared with those of systems at equilibrium.
Ng, P K
1980-07-01
This paper describes the use of a programmable calculator (HP-97) to determine the individualized Michaelis-Menten parameters of phenytoin by utilising the linear regression technique in fitting data of multiple doses and corresponding steady-state concentrations to a linear-transformed Michaelis-Menten equation and solving for the Michaelis-Menten parameters. In addition, the calculator program can predict the corresponding steady-state concentration of phenytoin for any given dose used in an individual by employing the derived Michaelis-Menten parameters and the Michaelis-Menten equation.
Spectral characteristics of steady-state Lévy flights in confinement potential profiles
NASA Astrophysics Data System (ADS)
Kharcheva, A. A.; Dubkov, A. A.; Dybiec, B.; Spagnolo, B.; Valenti, D.
2016-05-01
The steady-state correlation characteristics of superdiffusion in the form of Lévy flights in one-dimensional confinement potential profiles are investigated both theoretically and numerically. Specifically, for Cauchy stable noise we calculate the steady-state probability density function for an infinitely deep rectangular potential well and for a symmetric steep potential well of the type U(x)\\propto {{x}2m} . For these potential profiles and arbitrary Lévy index α, we obtain the asymptotic expression of the spectral power density.
Transient and steady-state velocity of domain walls for a complete range of drive fields
NASA Technical Reports Server (NTRS)
Bourne, H. C., Jr.; Bartran, D. S.
1974-01-01
Approximate analytic solutions for transient and steady-state 180 deg domain wall motion in bulk magnetic material are obtained from the dynamic torque equations with a Gilbert damping term. The results for the Walker region in which the transient solution approaches the familiar Walker steady-state solution are presented in a slightly new form for completeness. An analytic solution corresponding to larger drive fields predicts an oscillatory motion with an average value which decreases with drive field for reasonable values of the damping parameter. These results agree with those obtained by a computer solution of the torque equation and those obtained with the assumption of a very large anisotropy field.
Characterization of polyester films used in capacitors. 1: Transient and steady-state conductivity
NASA Astrophysics Data System (ADS)
Thielen, A.; Niezette, J.; Feyder, G.; Vanderschueren, J.
1994-10-01
Charging and discharging currents flowing through polyethylene terephthalate (PET) ultrathin films (1.5 - 12 micrometers) were measured by the use of a two-electrode configuration involving opposite lateral contacts. A study of the influence of electrification time, applied electric field, film thickness, nature of electrodes, and water content was carried out on both transient and steady-state conduction. The transient behavior can be interpreted in terms of dipolar orientation and relaxation processes while steady-state conductivity can be mainly accounted for in terms of Schottky emission. A comparison between PET and polyethylene naphthalate films is also reported.
Design of a new VHF RF power amplifier system for LANSCE
Lyles, John T M
2010-01-01
A major upgrade is replacing much of the 40 year-old proton drift tube linac RF system with new components at the Los Alamos Neutron Science Center (LANSCE). When installed, the new system will reduce the total number of electron power tubes from twenty-four to eight in the RF powerplant. A new 200 MHz high power cavity amplifier has being developed at LANSCE. This 3.2 MW final power amplifier (FPA) uses a Thales TH628 Diacrode{reg_sign}, a state-of-the-art tetrode that eliminates the large anode modulator of the triode-based FPA that has been in use for four decades. Drive power for the FPA is provided by a new tetrode intermediate power amplifier (and a solid-state driver stage). The new system has sufficient duty-factor capability to allow LANSCE to return to 1 MW beam operation. Prototype RF power amplifiers have been designed, fabricated, and assembled, and are being tested. High voltage DC power became available through innovative re-engineering of an installed system. Details of the electrical and mechanical design of the FPA and ancillary systems are discussed.
Elimination of Thermodynamically Infeasible Loops in Steady-State Metabolic Models
Schellenberger, Jan; Lewis, Nathan E.; Palsson, Bernhard Ø.
2011-01-01
The constraint-based reconstruction and analysis (COBRA) framework has been widely used to study steady-state flux solutions in genome-scale metabolic networks. One shortcoming of current COBRA methods is the possible violation of the loop law in the computed steady-state flux solutions. The loop law is analogous to Kirchhoff's second law for electric circuits, and states that at steady state there can be no net flux around a closed network cycle. Although the consequences of the loop law have been known for years, it has been computationally difficult to work with. Therefore, the resulting loop-law constraints have been overlooked. Here, we present a general mixed integer programming approach called loopless COBRA (ll-COBRA), which can be used to eliminate all steady-state flux solutions that are incompatible with the loop law. We apply this approach to improve flux predictions on three common COBRA methods: flux balance analysis, flux variability analysis, and Monte Carlo sampling of the flux space. Moreover, we demonstrate that the imposition of loop-law constraints with ll-COBRA improves the consistency of simulation results with experimental data. This method provides an additional constraint for many COBRA methods, enabling the acquisition of more realistic simulation results. PMID:21281568
LANSCE (Los Alamos Neutron Scattering Center) target data collection system
Kernodle, A.K. )
1988-01-01
The Los Alamos Neutron Scattering Center (LANSCE) Target Data Collection System is the result of an effort to provide a base of information from which to draw conclusions on the performance and operational condition of the overall LANSCE target system. During the conceptualization of the system several purposes and goals were defined. A survey was made of custom as well as off the shelf hardware and software which was capable of meeting these goals. The first stage of this system was successfully implemented for the LANSCE run cycle 52. From the operational experience gained thus far with the LANSCE Target Data Collection System, it would appear as though this system will indeed meet all of the previously defined requirements that seem to develop after a new system is installed.
Alarcón, Tomás
2014-05-14
In this paper, we propose two methods to carry out the quasi-steady state approximation in stochastic models of enzyme catalytic regulation, based on WKB asymptotics of the chemical master equation or of the corresponding partial differential equation for the generating function. The first of the methods we propose involves the development of multiscale generalisation of a WKB approximation of the solution of the master equation, where the separation of time scales is made explicit which allows us to apply the quasi-steady state approximation in a straightforward manner. To the lowest order, the multi-scale WKB method provides a quasi-steady state, Gaussian approximation of the probability distribution. The second method is based on the Hamilton-Jacobi representation of the stochastic process where, as predicted by large deviation theory, the solution of the partial differential equation for the corresponding characteristic function is given in terms of an effective action functional. The optimal transition paths between two states are then given by those paths that maximise the effective action. Such paths are the solutions of the Hamilton equations for the Hamiltonian associated to the effective action functional. The quasi-steady state approximation is applied to the Hamilton equations thus providing an approximation to the optimal transition paths and the transition time between two states. Using this approximation we predict that, unlike the mean-field quasi-steady approximation result, the rate of enzyme catalysis depends explicitly on the initial number of enzyme molecules. The accuracy and validity of our approximated results as well as that of our predictions regarding the behaviour of the stochastic enzyme catalytic models are verified by direct simulation of the stochastic model using Gillespie stochastic simulation algorithm.
Alarcón, Tomás
2014-05-14
In this paper, we propose two methods to carry out the quasi-steady state approximation in stochastic models of enzyme catalytic regulation, based on WKB asymptotics of the chemical master equation or of the corresponding partial differential equation for the generating function. The first of the methods we propose involves the development of multiscale generalisation of a WKB approximation of the solution of the master equation, where the separation of time scales is made explicit which allows us to apply the quasi-steady state approximation in a straightforward manner. To the lowest order, the multi-scale WKB method provides a quasi-steady state, Gaussian approximation of the probability distribution. The second method is based on the Hamilton-Jacobi representation of the stochastic process where, as predicted by large deviation theory, the solution of the partial differential equation for the corresponding characteristic function is given in terms of an effective action functional. The optimal transition paths between two states are then given by those paths that maximise the effective action. Such paths are the solutions of the Hamilton equations for the Hamiltonian associated to the effective action functional. The quasi-steady state approximation is applied to the Hamilton equations thus providing an approximation to the optimal transition paths and the transition time between two states. Using this approximation we predict that, unlike the mean-field quasi-steady approximation result, the rate of enzyme catalysis depends explicitly on the initial number of enzyme molecules. The accuracy and validity of our approximated results as well as that of our predictions regarding the behaviour of the stochastic enzyme catalytic models are verified by direct simulation of the stochastic model using Gillespie stochastic simulation algorithm.
Design of the next generation target at Lujan center, LANSCE.
Ferres, Laurent
2016-07-27
This is a presentation given at Los Alamos National Laboratory (LANL) on the design of the next generation target at Lujan center, LANSCE. The motivation for this design is to enable new nuclear physics experiments (defense program applications (DANCE)) that are currently limited by neutron intensity or energy resolution available at LANSCE. The target is being redesigned so that the Flight Paths in the upper tier provide a higher intensity in the epithermal and medium energy ranges.
Transient and steady state photoelectronic analysis in TlInSe{sub 2} crystals
Qasrawi, A.F.; Gasanly, N.M.
2011-08-15
Highlights: {yields} The steady state and time dependent photoconductivity kinetics of the TlInSe{sub 2} crystals are investigated in the temperature region of 100-350 K. {yields} The photocurrent of the sample exhibited linear, sublinear, and supralinear recombination mechanisms, at, above and below 160 K, respectively. {yields} Steady state photoconductivity revealed two recombination centres located at 234 and 94 meV. {yields} The transient photoconductivity is limited by a trapping center located at 173 meV. {yields} The capture coefficient of the trap for holes was determined as 3.11 x 10{sup -22} cm{sup -2}. -- Abstract: The temperature and illumination effects on the transient and steady state photoconductivities of TlInSe{sub 2} crystals have been studied. Namely, two recombination centres located at 234 and at 94 meV and one trap center located at 173 meV were determined from the temperature-dependent steady state and transient photoconductivities, respectively. The illumination dependence of photoconductivity indicated the domination of sublinear and supralinear recombination mechanisms above and below 160 K, respectively. The change in the recombination mechanism is attributed to the exchange of roles between the linear recombination at the surface and trapping centres in the crystal, which become dominant as temperature decreases. The transient photoconductivity measurement allowed the determination of the capture coefficient of traps for holes as 3.11 x 10{sup -22} cm{sup -2}.
Quantifying biases in non-steady state chamber measurements of soil-atmosphere gas exchange
Technology Transfer Automated Retrieval System (TEKTRAN)
Limitations of non-steady state (NSS) chamber methods for determining soil-to-atmosphere trace gas exchange rates have been recognized for several decades. Of these limitations, the so-called “chamber effect” is one of the most challenging to overcome. The chamber effect can be defined as the inhere...
40 CFR 86.1362-2010 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Torque(percent) 2 3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition..., command a linear progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at the commanded engine...
40 CFR 86.1362 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2014 CFR
2014-07-01
... Torque(percent) 2 3 1a Steady-state 170 Warm Idle 0. 1b Transition 20 Linear Transition Linear Transition... transition phase, command a linear progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at...
40 CFR 86.1362-2007 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Torque(percent) 2,3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition... progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at the commanded engine speed. (c) During...
40 CFR 86.1362-2007 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Torque(percent) 2,3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition... progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at the commanded engine speed. (c) During...
40 CFR 86.1362-2010 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Torque(percent) 2 3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition..., command a linear progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at the commanded engine...
40 CFR 86.1362-2007 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Torque(percent) 2,3 1a Steady-state 170 Warm Idle 0 1b Transition 20 Linear Transition Linear Transition... progression from the speed or torque setting of the current mode to the speed or torque setting of the next mode. 3 The percent torque is relative to maximum torque at the commanded engine speed. (c) During...
Steady-State Fluorescence Anisotropy to Investigate Flavonoids Binding to Proteins
ERIC Educational Resources Information Center
Ingersoll, Christine M.; Strollo, Christen M.
2007-01-01
The steady-state fluorescence anisotropy is employed to study the binding of protein of a model protein, human serum albumin, to a commonly used flavonoid, quercetin. The experiment describes the thermodynamics, as well as the biochemical interactions of such binding effectively.
NASA Technical Reports Server (NTRS)
Giebler, K. N.
1966-01-01
Computer program evaluates heat transfer modes and calculates either the transient or steady-state temperature distributions throughout an object of complex shape when heat sources are applied to specified points on the object. It uses an electrothermal model to simulate the conductance, heat capacity, and temperature potential of the object.
User's instructions for the 41-node thermoregulatory model (steady state version)
NASA Technical Reports Server (NTRS)
Leonard, J. I.
1974-01-01
A user's guide for the steady-state thermoregulatory model is presented. The model was modified to provide conversational interaction on a remote terminal, greater flexibility for parameter estimation, increased efficiency of convergence, greater choice of output variable and more realistic equations for respiratory and skin diffusion water losses.
Impurity shielding criteria for steady state hydrogen plasmas in the LHD, a heliotron-type device
NASA Astrophysics Data System (ADS)
Nakamura, Y.; Kobayashi, M.; Yoshimura, S.; Tamura, N.; Yoshinuma, M.; Tanaka, K.; Suzuki, C.; Peterson, B. J.; Sakamoto, R.; Morisaki, T.; the LHD Experiment Group
2014-07-01
Impurity behavior has so far been investigated in steady state hydrogen plasmas in the Large Helical Device, which is a heliotron-type device and excellent for steady state operation. There was always found to be an impurity accumulation window, as observed before (Nakamura et al 2002 Plasma Phys. Control. Fusion 44 2121, Nakamura et al 2003 Nucl. Fusion 43 219). To clarify the boundary conditions, the dependences of impurity transport on edge plasma parameters are investigated with a database of steady state hydrogen discharges, and the boundary conditions for the impurity accumulation window are discussed. It is found that two different types of impurity screening effects are essential for preventing intrinsic impurities from entering the core plasma. One of them is due to positive radial electric field at the plasma edge on the low collisionality side and the other is impurity retention caused by friction force in the ergodic layer on the high collisionality side. The classification of steady state discharges on n-T space shows that the impurity behavior can be predicted by the impurity shielding criteria based on each empirical scaling.
Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems
Malik, Wasim Q.; Truccolo, Wilson; Brown, Emery N.; Hochberg, Leigh R.
2011-01-01
The Kalman filter is commonly used in neural interface systems to decode neural activity and estimate the desired movement kinematics. We analyze a low-complexity Kalman filter implementation in which the filter gain is approximated by its steady-state form, computed offline before real-time decoding commences. We evaluate its performance using human motor cortical spike train data obtained from an intracortical recording array as part of an ongoing pilot clinical trial. We demonstrate that the standard Kalman filter gain converges to within 95% of the steady-state filter gain in 1.5 ± 0.5 s (mean ± s.d.). The difference in the intended movement velocity decoded by the two filters vanishes within 5 s, with a correlation coefficient of 0.99 between the two decoded velocities over the session length. We also find that the steady-state Kalman filter reduces the computational load (algorithm execution time) for decoding the firing rates of 25 ± 3 single units by a factor of 7.0 ± 0.9. We expect that the gain in computational efficiency will be much higher in systems with larger neural ensembles. The steady-state filter can thus provide substantial runtime efficiency at little cost in terms of estimation accuracy. This far more efficient neural decoding approach will facilitate the practical implementation of future large-dimensional, multisignal neural interface systems. PMID:21078582
HU, T.A.
2005-10-27
Assess the steady-state flammability level at normal and off-normal ventilation conditions. The hydrogen generation rate was calculated for 177 tanks using the rate equation model. Flammability calculations based on hydrogen, ammonia, and methane were performed for 177 tanks for various scenarios.
ROLE OF NMDA, NICOTINIC, AND GABA RECEPTORS IN THE STEADY STATE VISUAL EVOKED POTENTIAL IN RATS.
This manuscript characterizes the receptor pathways involved in pattern-evoked potential generation in rats
" NMDA and nicotinic acetylcholine receptors appear to be involved in the generation of the steady-state pattern evoked response in vivo.
" The pattern evok...
40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Steady-State Duty Cycles II Appendix II to Part 1042 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt....
TRANSIENT AND STEADY STATE STUDY OF PURE AND MIXED REFRIGERANTS IN A RESIDENTIAL HEAT PUMP
The report gives results of an experimental and theoretical investigation of the transient and steady state performance of a residential air-conditioning/heat pump (AC/HP) operating with different refrigerants. (NOTE: The project was motivated by environmental concerns related to...
Steady-State Clinical Pharmacokinetics of Bupropion Extended-Release In Youths
ERIC Educational Resources Information Center
Daviss, W. Burleson; Perel, James M.; Birmaher, Boris; Rudolph, George R.; Melhem, Imad; Axelson, David A.; Brent, David A.
2006-01-01
Objective: To examine in children and adolescents the 24-hour, steady-state clinical pharmacokinetics of an extended-release (XL) formulation of bupropion (Wellbutrin XL). Method: Subjects were six male and four female patients (ages 11.5-16.2 years) prescribed bupropion XL in morning daily doses of either 150 mg (n = 5) or 300 mg (n = 5) for at…
Incorporation of wind generation to the Mexican power grid: Steady state analysis
Tovar, J.H.; Guardado, J.L.; Cisneros, F.; Cadenas, R.; Lopez, S.
1997-09-01
This paper describes a steady state analysis related with the incorporation of large amounts of eolic generation into the Mexican power system. An equivalent node is used to represent individual eolic generators in the wind farm. Possible overloads, losses, voltage and reactive profiles and estimated severe contingencies are analyzed. Finally, the conclusions of this study are presented.
NASA Astrophysics Data System (ADS)
Hershey, Kyle W.; Holmes, Russell J.
2016-11-01
Phosphorescent organic light-emitting devices (OLEDs) can suffer a significant reduction in device efficiency under high current density excitation. This steady-state efficiency roll-off is frequently modeled by including losses from exciton-exciton and exciton-polaron quenching. Despite success in modeling the steady-state efficiency roll-off, the corresponding transient electroluminescence behavior has not been modeled as effectively using the same quenching processes. In this work, both the steady-state and transient electroluminescence behavior of phosphorescent OLEDs based on tris[2-phenylpyridinato-C2,N]Iridium(III) (Ir(ppy)3) are successfully reproduced by considering a dynamic polaron population. Within this model, polarons are able to either form excitons or leak through the device emissive layer, reducing the overall efficiency. This formalism permits a natural and rigorous connection between exciton and polaron dynamics and device charge balance, with the charge balance cast as the efficiency of exciton formation. The full dynamics model reproduces both the rise and decay of transient electroluminescence, as well as the full dependence of the external quantum efficiency on current density. Fit parameters are independently verified using separate studies of transient and steady-state photoluminescence. The model provides a complete picture for the dynamics present during the electrical operation of phosphorescent OLEDs, while also offering a direct route to elucidate exciton formation.
Stable long-term blood formation by stem cells in murine steady-state hematopoiesis.
Zavidij, Oksana; Ball, Claudia R; Herbst, Friederike; Oppel, Felix; Fessler, Sylvia; Schmidt, Manfred; von Kalle, Christof; Glimm, Hanno
2012-09-01
Hematopoietic stem cells (HSCs) generate all mature blood cells during the whole lifespan of an individual. However, the clonal contribution of individual HSC and progenitor cells in steady-state hematopoiesis is poorly understood. To investigate the activity of HSCs under steady-state conditions, murine HSC and progenitor cells were genetically marked in vivo by integrating lentiviral vectors (LVs) encoding green fluorescent protein (GFP). Hematopoietic contribution of individual marked clones was monitored by determination of lentiviral integration sites using highly sensitive linear amplification-mediated-polymerase chain reaction. A remarkably stable small proportion of hematopoietic cells expressed GFP in LV-injected animals for up to 24 months, indicating stable marking of murine steady-state hematopoiesis. Analysis of the lentiviral integration sites revealed that multiple hematopoietic clones with both myeloid and lymphoid differentiation potential contributed to long-term hematopoiesis. In contrast to intrafemoral vector injection, intravenous administration of LV preferentially targeted short-lived progenitor cells. Myelosuppressive treatment of mice prior to LV-injection did not affect the marking efficiency. Our study represents the first continuous analysis of clonal behavior of genetically marked hematopoietic cells in an unmanipulated system, providing evidence that multiple clones are simultaneously active in murine steady-state hematopoiesis.
Steady-state choice between four alternatives obeys the constant-ratio rule.
Bensemann, Joshua; Lobb, Brenda; Podlesnik, Christopher A; Elliffe, Douglas
2015-07-01
We investigated why violations to the constant-ratio rule, an assumption of the generalized matching law, occur in procedures that arrange frequent changes to reinforcer ratios. Our investigation produced steady-state data and compared them with data from equivalent, frequently changing procedures. Six pigeons responded in a four-alternative concurrent-schedule experiment with an arranged reinforcer-rate ratio of 27:9:3:1. The same four variable-interval schedules were used in every condition, for 50 sessions, and the physical location of each schedule was changed across conditions. The experiment was a steady-state version of a frequently changing procedure in which the locations of four VI schedules were changed every 10 reinforcers. We found that subjects' responding was consistent with the constant-ratio rule in the steady-state procedure. Additionally, local analyses showed that preference after reinforcement was towards the alternative that was likely to produce the next reinforcer, instead of being towards the just-reinforced alternative as in frequently changing procedures. This suggests that the effect of a reinforcer on preference is fundamentally different in rapidly changing and steady-state environments. Comparing this finding to the existing literature suggests that choice is more influenced by reinforcer-generated signals when the reinforcement contingencies often change.
A Sequential Procedure for Determining the Length of a Steady-State Simulation.
1977-04-01
A common problem faced by simulators is that of constructing a confidence interval for the steady-state mean of a stochastic process. We have...procedure based on the method of batch means for constructing a confidence interval with coverage close to the desired level. Empirical results for a large
HU TA
2009-10-26
Assess the steady-state flammability level at normal and off-normal ventilation conditions. The hydrogen generation rate was calculated for 177 tanks using the rate equation model. Flammability calculations based on hydrogen, ammonia, and methane were performed for 177 tanks for various scenarios.
40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles
Code of Federal Regulations, 2010 CFR
2010-07-01
... II to Part 1039 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Pt. 1039, App. II Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for...
40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part...
Analytical steady-state solutions for water-limited cropping systems using saline irrigation water
Technology Transfer Automated Retrieval System (TEKTRAN)
Due to the diminishing availability of good quality water for irrigation, it is increasingly important that irrigation and salinity management tools be able to target submaximal crop yields and support the use of marginal quality waters. In this work, we present a steady-state irrigated systems mod...
Proteome analysis of the Escherichia coli heat shock response under steady-state conditions
Lüders, Svenja; Fallet, Claas; Franco-Lara, Ezequiel
2009-01-01
In this study a proteomic approach was used to investigate the steady-state response of Escherichia coli to temperature up-shifts in a cascade of two continuously operated bioreactors. The first reactor served as cell source with optimal settings for microbial growth, while in the second chemostat the cells were exposed to elevated temperatures. By using this reactor configuration, which has not been reported to be used for the study of bacterial stress responses so far, it is possible to study temperature stress under well-defined, steady-state conditions. Specifically the effect on the cellular adaption to temperature stress using two-dimensional gel electrophoresis was examined and compared at the cultivation temperatures of 37°C and 47.5°C. As expected, the steady-state study with the double bioreactor configuration delivered a different protein spectrum compared to that obtained with standard batch experiments in shaking flasks and bioreactors. Setting a high cut-out spot-to-spot size ratio of 5, proteins involved in defence against oxygen stress, functional cell envelope proteins, chaperones and proteins involved in protein biosynthesis, the energy metabolism and the amino acid biosynthesis were found to be differently expressed at high cultivation temperatures. The results demonstrate the complexity of the stress response in a steady-state culture not reported elsewhere to date. PMID:19772559
Abnormal Attention in Autism Shown by Steady-State Visual Evoked Potentials.
ERIC Educational Resources Information Center
Belmonte, Matthew
2000-01-01
Eight males with autism were required to shift attention between rapidly flashed targets alternating between left and right visual hemifields. When targets were separated by less than 700 ms, steady-state brain electrical response in both hemispheres was augmented and background EEG decreased for rightward shifts as compared with leftward shifts.…
A hybrid multigrid technique for computing steady-state solutions to supersonic flows
NASA Technical Reports Server (NTRS)
Sanders, Richard
1992-01-01
Recently, Li and Sanders have introduced a class of finite difference schemes to approximate generally discontinuous solutions to hyperbolic systems of conservation laws. These equations have the form together with relevant boundary conditions. When modelling hypersonic spacecraft reentry, the differential equations above are frequently given by the compressible Euler equations coupled with a nonequilibrium chemistry model. For these applications, steady state solutions are often sought. Many tens (to hundreds) of super computer hours can be devoted to a single three space dimensional simulation. The primary difficulty is the inability to rapidly and reliably capture the steady state. In these notes, we demonstrate that a particular variant from the schemes presented can be combined with a particular multigrid approach to capture steady state solutions to the compressible Euler equations in one space dimension. We show that the rate of convergence to steady state coming from this multigrid implementation is vastly superior to the traditional approach of artificial time relaxation. Moreover, we demonstrate virtual grid independence. That is, the rate of convergence does not depend on the degree of spatial grid refinement.
Einstein's steady-state theory: an abandoned model of the cosmos
NASA Astrophysics Data System (ADS)
O'Raifeartaigh, Cormac; McCann, Brendan; Nahm, Werner; Mitton, Simon
2014-09-01
We present a translation and analysis of an unpublished manuscript by Albert Einstein in which he attempted to construct a `steady-state' model of the universe. The manuscript, which appears to have been written in early 1931, demonstrates that Einstein once explored a cosmic model in which the mean density of matter in an expanding universe is maintained constant by the continuous formation of matter from empty space. This model is very different to previously known Einsteinian models of the cosmos (both static and dynamic) but anticipates the later steady-state cosmology of Hoyle, Bondi and Gold in some ways. We find that Einstein's steady-state model contains a fundamental flaw and suggest that it was abandoned for this reason. We also suggest that he declined to explore a more sophisticated version because he found such theories rather contrived. The manuscript is of historical interest because it reveals that Einstein debated between steady-state and evolving models of the cosmos decades before a similar debate took place in the cosmological community.
The Cost Structure of Higher Education: Implications for Governmental Policy in Steady State.
ERIC Educational Resources Information Center
Lyell, Edward H.
The historical pattern of resource allocation in American higher education as exemplified by public colleges in Colorado was examined. The reliance upon average cost information in making resource allocation decisions was critiqued for the special problems that arise from student enrollment decline or steady state. A model of resource allocation…
40 CFR Appendix D to Subpart S of... - Steady-State Short Test Equipment
Code of Federal Regulations, 2014 CFR
2014-07-01
.../Maintenance Program Requirements Pt. 51, Subpt. S, App. D Appendix D to Subpart S of Part 51—Steady-State..., a flexible sample line, a water removal system, particulate trap, sample pump, flow control... flow rate in each leg of the probe has been measured under two sample pump flow rates (the normal...
40 CFR Appendix D to Subpart S of... - Steady-State Short Test Equipment
Code of Federal Regulations, 2012 CFR
2012-07-01
.../Maintenance Program Requirements Pt. 51, Subpt. S, App. D Appendix D to Subpart S of Part 51—Steady-State..., a flexible sample line, a water removal system, particulate trap, sample pump, flow control... flow rate in each leg of the probe has been measured under two sample pump flow rates (the normal...
40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part...
HU, T.A.
2000-04-27
This work is to assess the steady-state flammability level at normal and off-normal ventilation conditions in the tank dome space for 177 double-shell and single-shell tanks at Hanford. Hydrogen generation rate was calculated for 177 tanks using rate equation model developed recently.
Walkway Length Determination for Steady State Walking in Young and Older Adults
ERIC Educational Resources Information Center
Macfarlane, Pamela A.; Looney, Marilyn A.
2008-01-01
The primary purpose of this study was to determine acceleration (AC) and deceleration (DC) distances that would accommodate young and older adults walking at their preferred and fast speeds. A secondary purpose was to determine the minimal walkway length needed to record six steady state (SS) steps (three full gait cycles) for younger and older…
Radioactivity computation of steady-state and pulsed fusion reactors operation
Attaya, H.
1994-06-01
Different mathematical methods are used to calculate the nuclear transmutation in steady-state and pulsed neutron irradiation. These methods are the Schuer decomposition, the eigenvector decomposition, and the Pade approximation of the matrix exponential function. In the case of the linear decay chain approximation, a simple algorithm is used to evaluate the transition matrices.
System and method for generating steady state confining current for a toroidal plasma fusion reactor
Bers, Abraham
1981-01-01
A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma.
System and method for generating steady state confining current for a toroidal plasma fusion reactor
Fisch, Nathaniel J.
1981-01-01
A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma.
Thermal shock behaviour of blisters on W surface during combined steady-state/pulsed plasma loading
NASA Astrophysics Data System (ADS)
Jia, Y. Z.; Liu, W.; Xu, B.; Luo, G.-N.; Li, C.; Qu, S. L.; Morgan, T. W.; De Temmerman, G.
2015-09-01
The thermal shock behaviour of blister-covered W surfaces during combined steady-state/pulsed plasma loading was studied by scanning electron microscopy and electron backscatter diffraction. The W samples were first exposed to steady-state D plasma to induce blisters on the surface, and then the blistered surfaces were exposed to steady-state/pulsed plasma. Growth and cracking of blisters were observed after the exposure to the steady-state/pulsed plasma, while no obvious damage occurred on the surface area not covered with blisters. The results confirm that blisters induced by D plasma might represent weak spots on the W surface when exposed to transient heat load of ELMs. The cracks on blisters were different from the cracks due to the transient heat loads reported before, and they were assumed to be caused by stress and strain due to the gas expansion inside the blisters during the plasma pulses. Moreover, most of cracks were found to appear on the blisters formed on grains with surface orientation near [1 1 1].
Technology Transfer Automated Retrieval System (TEKTRAN)
Several flux-calculation (FC) schemes are available for determining soil-to-atmosphere emissions of nitrous oxide (N2O) and other trace gases using data from non-steady-state flux chambers. Recently developed methods claim to provide more accuracy in estimating the true pre-deployment flux (f0) comp...
Pre-steady-state kinetics for hydrolysis of insoluble cellulose by cellobiohydrolase Cel7A.
Cruys-Bagger, Nicolaj; Elmerdahl, Jens; Praestgaard, Eigil; Tatsumi, Hirosuke; Spodsberg, Nikolaj; Borch, Kim; Westh, Peter
2012-05-25
The transient kinetic behavior of enzyme reactions prior to the establishment of steady state is a major source of mechanistic information, yet this approach has not been utilized for cellulases acting on their natural substrate, insoluble cellulose. Here, we elucidate the pre-steady-state regime for the exo-acting cellulase Cel7A using amperometric biosensors and an explicit model for processive hydrolysis of cellulose. This analysis allows the identification of a pseudo-steady-state period and quantification of a processivity number as well as rate constants for the formation of a threaded enzyme complex, processive hydrolysis, and dissociation, respectively. These kinetic parameters elucidate limiting factors in the cellulolytic process. We concluded, for example, that Cel7A cleaves about four glycosidic bonds/s during processive hydrolysis. However, the results suggest that stalling the processive movement and low off-rates result in a specific activity at pseudo-steady state that is 10-25-fold lower. It follows that the dissociation of the enzyme-substrate complex (half-time of ~30 s) is rate-limiting for the investigated system. We suggest that this approach can be useful in attempts to unveil fundamental reasons for the distinctive variability in hydrolytic activity found in different cellulase-substrate systems.
Programmable calculator uses equation to figure steady-state gas-pipeline flow
Holmberg, E.
1982-04-26
Because it is accurate and consistent over a wide range of variables, the Colebrook-White (C-W) formula serves as the basis for many methods of calculating turbulent flow in gas pipelines. Oilconsult reveals a simple way to adapt the C-W formula to calculate steady-state pipeline flow using the TI-59 programmable calculator.
40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part...
40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part...
Efficient decoding with steady-state Kalman filter in neural interface systems.
Malik, Wasim Q; Truccolo, Wilson; Brown, Emery N; Hochberg, Leigh R
2011-02-01
The Kalman filter is commonly used in neural interface systems to decode neural activity and estimate the desired movement kinematics. We analyze a low-complexity Kalman filter implementation in which the filter gain is approximated by its steady-state form, computed offline before real-time decoding commences. We evaluate its performance using human motor cortical spike train data obtained from an intracortical recording array as part of an ongoing pilot clinical trial. We demonstrate that the standard Kalman filter gain converges to within 95% of the steady-state filter gain in 1.5±0.5 s (mean ±s.d.). The difference in the intended movement velocity decoded by the two filters vanishes within 5 s, with a correlation coefficient of 0.99 between the two decoded velocities over the session length. We also find that the steady-state Kalman filter reduces the computational load (algorithm execution time) for decoding the firing rates of 25±3 single units by a factor of 7.0±0.9. We expect that the gain in computational efficiency will be much higher in systems with larger neural ensembles. The steady-state filter can thus provide substantial runtime efficiency at little cost in terms of estimation accuracy. This far more efficient neural decoding approach will facilitate the practical implementation of future large-dimensional, multisignal neural interface systems.
An implicit steady-state initialization package for the RELAP5 computer code
Paulsen, M.P.; Peterson, C.E.; Odar, F.
1995-08-01
A direct steady-state initialization (DSSI) method has been developed and implemented in the RELAP5 hydrodynamic analysis program. It provides a means for users to specify a small set of initial conditions which are then propagated through the remainder of the system. The DSSI scheme utilizes the steady-state form of the RELAP5 balance equations for nonequilibrium two-phase flow. It also employs the RELAP5 component models and constitutive model packages for wall-to-phase and interphase momentum and heat exchange. A fully implicit solution of the linearized hydrodynamic equations is implemented. An implicit coupling scheme is used to augment the standard steady-state heat conduction solution for steam generator use. It solves the primary-side tube region energy equations, heat conduction equations, wall heat flux boundary conditions, and overall energy balance equation as a coupled system of equations and improves convergence. The DSSI method for initializing RELAP5 problems to steady-state conditions has been compared with the transient solution scheme using a suite of test problems including; adiabatic single-phase liquid and vapor flow through channels with and without healing and area changes; a heated two-phase test bundle representative of BWR core conditions; and a single-loop PWR model.
Steady-state chlorophyll flourescence (Fs) as a tool to monitor plant heat and drought stress
Technology Transfer Automated Retrieval System (TEKTRAN)
Crop yield decreases when photosynthesis is limited by heat or drought conditions. Yet farmers do not monitor crop photosynthesis because it is difficult to measure at the field scale in real time. Steady-state chlorophyll fluorescence (Fs) can be used at the field level as an indirect measure of p...
NASA Technical Reports Server (NTRS)
Sellers, J. F.; Daniele, C. J.
1975-01-01
The DYNGEN, a digital computer program for analyzing the steady state and transient performance of turbojet and turbofan engines, is described. The DYNGEN is based on earlier computer codes (SMOTE, GENENG, and GENENG 2) which are capable of calculating the steady state performance of turbojet and turbofan engines at design and off-design operating conditions. The DYNGEN has the combined capabilities of GENENG and GENENG 2 for calculating steady state performance; to these the further capability for calculating transient performance was added. The DYNGEN can be used to analyze one- and two-spool turbojet engines or two- and three-spool turbofan engines without modification to the basic program. A modified Euler method is used by DYNGEN to solve the differential equations which model the dynamics of the engine. This new method frees the programmer from having to minimize the number of equations which require iterative solution. As a result, some of the approximations normally used in transient engine simulations can be eliminated. This tends to produce better agreement when answers are compared with those from purely steady state simulations. The modified Euler method also permits the user to specify large time steps (about 0.10 sec) to be used in the solution of the differential equations. This saves computer execution time when long transients are run. Examples of the use of the program are included, and program results are compared with those from an existing hybrid-computer simulation of a two-spool turbofan.
40 CFR 86.1362-2007 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2010 CFR
2010-07-01
... procedures specified in § 86.1363-2007 through the 2009 model year. (a) Start sampling at the beginning of the first mode and continue sampling until the end of the last mode. Calculate emissions as described... meets the applicable steady-state emission standards: RMC mode Time in mode (seconds) Enginespeed...
40 CFR 86.1362-2010 - Steady-state testing with a ramped-modal cycle.
Code of Federal Regulations, 2010 CFR
2010-07-01
... describes how to test engines under steady-state conditions. For model years through 2009, manufacturers may use the mode order described in this section or in § 86.1362-2007. Starting in model year 2010 manufacturers must use the mode order described in this section with the following exception: for model...
A Steady State Visually Evoked Potential Investigation of Memory and Ageing
ERIC Educational Resources Information Center
Macpherson, Helen; Pipingas, Andrew; Silberstein, Richard
2009-01-01
Old age is generally accompanied by a decline in memory performance. Specifically, neuroimaging and electrophysiological studies have revealed that there are age-related changes in the neural correlates of episodic and working memory. This study investigated age-associated changes in the steady state visually evoked potential (SSVEP) amplitude and…
Existence of a steady state of a natural convective flow in a confined medium
NASA Astrophysics Data System (ADS)
Pignatel, J.-F.; Marcillat, J.
1983-04-01
Experimental results are presented from a study of convective flow in a parallelipiped-shaped cavity with walls maintained at different temperatures. Resistive heaters permitted varying the wall temperatures up to 150 C, and the container could be tilted from 0-90 deg. Air was used as the fluid medium, with Rayleigh numbers from 2000-1,000,000. The flows studied featured the appearances of both steady and unsteady instabilities. Attention was given to vertical movements and a two-dimensional numerical model was defined. Attempts were made to identify the limits of a steady state in terms of the Rayleigh number, the shape factors, and the tilt of the cavity.
STEADY-STATE RELATIVISTIC STELLAR DYNAMICS AROUND A MASSIVE BLACK HOLE
Bar-Or, Ben; Alexander, Tal
2016-04-01
A massive black hole (MBH) consumes stars whose orbits evolve into the small phase-space volume of unstable orbits, the “loss cone,” which take them into the MBH, or close enough to interact strongly with it. The resulting phenomena, e.g., tidal heating and disruption, binary capture and hyper-velocity star ejection, gravitational wave (GW) emission by inspiraling compact remnants, or hydrodynamical interactions with an accretion disk, can produce observable signatures and thereby reveal the MBH, affect its mass and spin evolution, test strong gravity, and probe stars and gas near the MBH. These continuous stellar loss and resupply processes shape the central stellar distribution. We investigate relativistic stellar dynamics near the loss cone of a non-spinning MBH in steady state, analytically and by Monte Carlo simulations of the diffusion of the orbital parameters. These take into account Newtonian mass precession due to enclosed stellar mass, in-plane precession due to general relativity, dissipation by GW, uncorrelated two-body relaxation, correlated resonant relaxation (RR), and adiabatic invariance due to secular precession, using a rigorously derived description of correlated post-Newtonian dynamics in the diffusion limit. We argue that general maximal entropy considerations strongly constrain the orbital diffusion in steady state, irrespective of the relaxation mechanism. We identify the exact phase-space separatrix between plunges and inspirals, and predict their steady-state rates. We derive the dependence of the rates on the mass of the MBH, show that the contribution of RR in steady state is small, and discuss special cases where unquenched RR in restricted volumes of phase-space may affect the steady state substantially.
Analytical models of steady-state plumes undergoing sequential first-order degradation.
Burnell, Daniel K; Mercer, James W; Sims, Lawrence S
2012-01-01
An exact, closed-form analytical solution is derived for one-dimensional (1D), coupled, steady-state advection-dispersion equations with sequential first-order degradation of three dissolved species in groundwater. Dimensionless and mathematical analyses are used to examine the sensitivity of longitudinal dispersivity in the parent and daughter analytical solutions. The results indicate that the relative error decreases to less than 15% for the 1D advection-dominated and advection-dispersion analytical solutions of the parent and daughter when the Damköhler number of the parent decreases to less than 1 (slow degradation rate) and the Peclet number increases to greater than 6 (advection-dominated). To estimate first-order daughter product rate constants in advection-dominated zones, 1D, two-dimensional (2D), and three-dimensional (3D) steady-state analytical solutions with zero longitudinal dispersivity are also derived for three first-order sequentially degrading compounds. The closed form of these exact analytical solutions has the advantage of having (1) no numerical integration or evaluation of complex-valued error function arguments, (2) computational efficiency compared to problems with long times to reach steady state, and (3) minimal effort for incorporation into spreadsheets. These multispecies analytical solutions indicate that BIOCHLOR produces accurate results for 1D steady-state, applications with longitudinal dispersion. Although BIOCHLOR is inaccurate in multidimensional applications with longitudinal dispersion, these multidimensional multispecies analytical solutions indicate that BIOCHLOR produces accurate steady-state results when the longitudinal dispersion is zero. As an application, the 1D advection-dominated analytical solution is applied to estimate field-scale rate constants of 0.81, 0.74, and 0.69/year for trichloroethene, cis-1,2-dichloroethene, and vinyl chloride, respectively, at the Harris Palm Bay, FL, CERCLA site.
Uncertainties from the determination of the steady state in borehole climatology
NASA Astrophysics Data System (ADS)
Matharoo, G. S.; Beltrami, H.; Smerdon, J. E.
2010-12-01
Temperature changes at the Earth's surface propagate and are recorded underground as perturbations to the equilibrium thermal regime associated with the heat flow from the Earth's interior. Borehole climatology is concerned with the analysis and interpretation of these downward propagating subsurface temperature anomalies in terms of surface climate; as such proper determination of the steady-state geothermal regime is crucial because it is the reference that determines the size and shape of the climate induced subsurface temperature anomalies. Here we examine the effects of data noise, of lithological or instrumental origin, on the determination of the steady-state geothermal regime of the subsurface and provide error bounds for a particular choice of ground surface temperature (GST) history. From a series of 1000 Montecarlo experiments using Gaussian noise (mean = 0; standard devation = ±0.02 K), a 100 m steady-state fitting interval, and a data sampling rate of 0.02 m, our results indicate that typical uncertainties for 50-year averages are on the order of ± 0.02 K for the most recent 100 year period. These uncertainties grow with decreasing sampling rate reaching about ± 0.1 K for a 10-m sampling rate under identical conditions and target period. Uncertainties increase for progressively older periods, reaching ±0.2K at 500 year before present for a 10-m sampling rate. The uncertainties in reconstructed GST histories are also inversely proportional to the length of the fitting range used to estimate the reference steady-state thermal regime. We suggest that continuous logging should be the preferred approach when measuring geothermal data for climate reconstructions and that the steady-state geothermal gradient be estimated from a large depth range(>100 m).
Steady-state Relativistic Stellar Dynamics Around a Massive Black hole
NASA Astrophysics Data System (ADS)
Bar-Or, Ben; Alexander, Tal
2016-04-01
A massive black hole (MBH) consumes stars whose orbits evolve into the small phase-space volume of unstable orbits, the “loss cone,” which take them into the MBH, or close enough to interact strongly with it. The resulting phenomena, e.g., tidal heating and disruption, binary capture and hyper-velocity star ejection, gravitational wave (GW) emission by inspiraling compact remnants, or hydrodynamical interactions with an accretion disk, can produce observable signatures and thereby reveal the MBH, affect its mass and spin evolution, test strong gravity, and probe stars and gas near the MBH. These continuous stellar loss and resupply processes shape the central stellar distribution. We investigate relativistic stellar dynamics near the loss cone of a non-spinning MBH in steady state, analytically and by Monte Carlo simulations of the diffusion of the orbital parameters. These take into account Newtonian mass precession due to enclosed stellar mass, in-plane precession due to general relativity, dissipation by GW, uncorrelated two-body relaxation, correlated resonant relaxation (RR), and adiabatic invariance due to secular precession, using a rigorously derived description of correlated post-Newtonian dynamics in the diffusion limit. We argue that general maximal entropy considerations strongly constrain the orbital diffusion in steady state, irrespective of the relaxation mechanism. We identify the exact phase-space separatrix between plunges and inspirals, and predict their steady-state rates. We derive the dependence of the rates on the mass of the MBH, show that the contribution of RR in steady state is small, and discuss special cases where unquenched RR in restricted volumes of phase-space may affect the steady state substantially.
Karst, Daniel J; Steinhoff, Robert F; Kopp, Marie R G; Serra, Elisa; Soos, Miroslav; Zenobi, Renato; Morbidelli, Massimo
2016-12-20
Perfusion cell culture processes allow the steady-state culture of mammalian cells at high viable cell density, which is beneficial for overall product yields and homogeneity of product quality in the manufacturing of therapeutic proteins. In this study, the extent of metabolic steady state and the change of the metabolite profile between different steady states of an industrial Chinese hamster ovary (CHO) cell line producing a monoclonal antibody (mAb) was investigated in stirred tank perfusion bioreactors. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) of daily cell extracts revealed more than a hundred peaks, among which 76 metabolites were identified by tandem MS (MS/MS) and high resolution Fourier transform ion cyclotron resonance (FT-ICR) MS. Nucleotide ratios (Uridine (U)-ratio, nucleotide triphosphate (NTP)-ratio and energy charge (EC)) and multivariate analysis of all features indicated a consistent metabolite profile for a stable culture performed at 40 × 10(6) cells/mL over 26 days of culture. Conversely, the reactor was operated continuously so as to reach three distinct steady states one after the other at 20, 60, and 40 × 10(6) cells/mL. In each case, a stable metabolite profile was achieved after an initial transient phase of approximately three days at constant cell density when varying between these set points. Clear clustering according to cell density was observed by principal component analysis, indicating steady-state dependent metabolite profiles. In particular, varying levels of nucleotides, nucleotide sugar, and lipid precursors explained most of the variance between the different cell density set points. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 2016.
Study on the steady operating state of a micro-pulse electron gun
Kui, Zhou; Xing, Luo; Xiangyang, Lu; Shengwen, Quan; Jifei, Zhao; Ziqin, Yang
2014-09-15
Micro-pulse electron gun (MPG) employs the basic concept of multipacting to produce high-current and short-pulse electron beams from a radio-frequency (RF) cavity. The concept of MPG has been proposed for more than two decades. However, the unstable operating state of MPG vastly obstructs its practical applications. This paper presents a study on the steady operating state of a micro-pulse electron gun with theory and experiments. The requirements for the steady operating state are proposed through the analysis of the interaction between the RF cavity and the beam load. Accordingly, a MPG cavity with the frequency of 2856 MHz has been designed, constructed, and tested. Some primary experiments have been finished. Both the unstable and stable operating states of the MPG have been observed. The stable output beam current has been detected at about 3.8 mA. Further experimental study is under way now.
A Series RCL Circuit Theory for Analyzing Non-Steady-State Water Uptake of Maize Plants
NASA Astrophysics Data System (ADS)
Zhuang, Jie; Yu, Gui-Rui; Nakayama, Keiichi
2014-10-01
Understanding water uptake and transport through the soil-plant continuum is vital for ecosystem management and agricultural water use. Plant water uptake under natural conditions is a non-steady transient flow controlled by root distribution, plant configuration, soil hydraulics, and climatic conditions. Despite significant progress in model development, a mechanistic description of transient water uptake has not been developed or remains incomplete. Here, based on advanced electrical network theory (RLC circuit theory), we developed a non-steady state biophysical model to mechanistically analyze the fluctuations of uptake rates in response to water stress. We found that the non-steady-state model captures the nature of instantaneity and hysteresis of plant water uptake due to the considerations of water storage in plant xylem and coarse roots (capacitance effect), hydraulic architecture of leaf system (inductance effect), and soil-root contact (fuse effect). The model provides insights into the important role of plant configuration and hydraulic heterogeneity in helping plants survive an adverse environment. Our tests against field data suggest that the non-steady-state model has great potential for being used to interpret the smart water strategy of plants, which is intrinsically determined by stem size, leaf size/thickness and distribution, root system architecture, and the ratio of fine-to-coarse root lengths.
A Series RCL Circuit Theory for Analyzing Non-Steady-State Water Uptake of Maize Plants
Zhuang, Jie; Yu, Gui-Rui; Nakayama, Keiichi
2014-01-01
Understanding water uptake and transport through the soil-plant continuum is vital for ecosystem management and agricultural water use. Plant water uptake under natural conditions is a non-steady transient flow controlled by root distribution, plant configuration, soil hydraulics, and climatic conditions. Despite significant progress in model development, a mechanistic description of transient water uptake has not been developed or remains incomplete. Here, based on advanced electrical network theory (RLC circuit theory), we developed a non-steady state biophysical model to mechanistically analyze the fluctuations of uptake rates in response to water stress. We found that the non-steady-state model captures the nature of instantaneity and hysteresis of plant water uptake due to the considerations of water storage in plant xylem and coarse roots (capacitance effect), hydraulic architecture of leaf system (inductance effect), and soil-root contact (fuse effect). The model provides insights into the important role of plant configuration and hydraulic heterogeneity in helping plants survive an adverse environment. Our tests against field data suggest that the non-steady-state model has great potential for being used to interpret the smart water strategy of plants, which is intrinsically determined by stem size, leaf size/thickness and distribution, root system architecture, and the ratio of fine-to-coarse root lengths. PMID:25335512
A series RCL circuit theory for analyzing non-steady-state water uptake of maize plants.
Zhuang, Jie; Yu, Gui-Rui; Nakayama, Keiichi
2014-10-22
Understanding water uptake and transport through the soil-plant continuum is vital for ecosystem management and agricultural water use. Plant water uptake under natural conditions is a non-steady transient flow controlled by root distribution, plant configuration, soil hydraulics, and climatic conditions. Despite significant progress in model development, a mechanistic description of transient water uptake has not been developed or remains incomplete. Here, based on advanced electrical network theory (RLC circuit theory), we developed a non-steady state biophysical model to mechanistically analyze the fluctuations of uptake rates in response to water stress. We found that the non-steady-state model captures the nature of instantaneity and hysteresis of plant water uptake due to the considerations of water storage in plant xylem and coarse roots (capacitance effect), hydraulic architecture of leaf system (inductance effect), and soil-root contact (fuse effect). The model provides insights into the important role of plant configuration and hydraulic heterogeneity in helping plants survive an adverse environment. Our tests against field data suggest that the non-steady-state model has great potential for being used to interpret the smart water strategy of plants, which is intrinsically determined by stem size, leaf size/thickness and distribution, root system architecture, and the ratio of fine-to-coarse root lengths.
A steady-state Kalman filter for assimilating data from a single polar orbiting satellite
NASA Technical Reports Server (NTRS)
Banfield, Don; Ingersoll, Andrew P.; Keppenne, Christian L.
1995-01-01
A steady-state scheme for data assimilation in the context of a single, short period (relative to a day), sun-synchronous, polar-orbiting satellite is examined. If the satellite takes observations continuously, the gains, which are the weights for blending observations and predictions together, are steady in time. For a linear system forced by random noise, the optimal steady-state gains (Wiener gains) are equivalent to those of a Kalman filter. Computing the Kalman gains increases the computational cost of the model by a large factor, but computing the Wiener gains does not. The latter are computed by iteration using prior estimates of the gains to assimilate simulated observations of one run of the model, termed 'truth' into another run termed 'prediction'. At each stage, the prediction errors form the basis for the next estimate of the gains. Steady state is achieved after three or four iterations. Further simplification is achieved by making the gains depend on longitudinal distance from the observation point, not on absolute longitude. For a single-layer primitive equation model, the scheme works well even if only the mass field is observed but not the velocity field. Although the scheme was developed for Mars Observer, it should be applicable to data retrieved from Earth atmosphere satellites, for example, UARS.
A new hybrid inductive scenario for a nearly steady-state Reversed Field Pinch
NASA Astrophysics Data System (ADS)
Sarff, J. S.
2007-11-01
Steady-state current sustainment is challenging for the Reversed Field Pinch (RFP). The current magnitude is large, while the pressure-driven (bootstrap) current is small, even at the RFP's high beta >20%. In the TITAN (RFP) system study [1], the current was designed steady-state using Oscillating Field Current Drive (OFCD), i.e., steady magnetic helicity injection using phased AC induction. Experiments and theory for OFCD are so far promising, but OFCD's reliance on magnetic relaxation could turn out incompatible with energy confinement requirements. Meanwhile inductive current profile control has demonstrated tokamak-like confinement in the RFP. Such control is inherently not steady-state. A hybrid scheme is proposed using OFCD to ramp the current, followed by a pulsed-burn during which inductive profile control maintains high confinement. The current is not constant but never goes to zero (sawtooth-like waveform). The current drive (and profile control) is efficient induction, simply applied at the plasma surface. The pulsed-burn phases could be separated by only a few seconds. Optimization of the hybrid cycle and other issues will be discussed. [1] http://aries.ucsd.edu/LIB/REPORT/TITAN/final.shtml
A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.
Preugschat, Frank; Carter, Luke H; Boros, Eric E; Porter, David J T; Stewart, Eugene L; Shewchuk, Lisa M
2014-12-15
hCD157 catalyzes the hydrolysis of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The release of nicotinamide or nicotinic acid from NR or NAR was confirmed by spectrophotometric, HPLC and NMR analyses. hCD157 is inactivated by a mechanism-based inhibitor, 2'-deoxy-2'-fluoro-nicotinamide arabinoside (fNR). Modification of the enzyme during the catalytic cycle by NR, NAR, or fNR increased the intrinsic protein fluorescence by approximately 50%. Pre-steady state and steady state data were used to derive a minimal kinetic scheme for the hydrolysis of NR. After initial complex formation a reversible step (360 and 30s(-1)) is followed by a slow irreversible step (0.1s(-1)) that defined the rate limiting step, or kcat. The calculated KMapp value for NR in the hydrolytic reaction is 6nM. The values of the kinetic constants suggest that one biological function of cell-surface hCD157 is to bind and slowly hydrolyze NR, possibly converting it to a ligand-activated receptor. Differences in substrate preference between hCD157 and hCD38 were rationalized through a comparison of the crystal structures of the two proteins. This comparison identified several residues in hCD157 (F108 and F173) that can potentially hinder the binding of dinucleotide substrates (NAD+).
2012-01-01
The Steady State (SS) probability distribution is an important quantity needed to characterize the steady state behavior of many stochastic biochemical networks. In this paper, we propose an efficient and accurate approach to calculating an approximate SS probability distribution from solution of the Chemical Master Equation (CME) under the assumption of the existence of a unique deterministic SS of the system. To find the approximate solution to the CME, a truncated state-space representation is used to reduce the state-space of the system and translate it to a finite dimension. The subsequent ill-posed eigenvalue problem of a linear system for the finite state-space can be converted to a well-posed system of linear equations and solved. The proposed strategy yields efficient and accurate estimation of noise in stochastic biochemical systems. To demonstrate the approach, we applied the method to characterize the noise behavior of a set of biochemical networks of ligand-receptor interactions for Bone Morphogenetic Protein (BMP) signaling. We found that recruitment of type II receptors during the receptor oligomerization by itself doesn't not tend to lower noise in receptor signaling, but regulation by a secreted co-factor may provide a substantial improvement in signaling relative to noise. The steady state probability approximation method shortened the time necessary to calculate the probability distributions compared to earlier approaches, such as Gillespie's Stochastic Simulation Algorithm (SSA) while maintaining high accuracy. PMID:23134718
Tabiś, Bolesław; Skoneczny, Szymon
2013-07-20
Nonlinear properties of a bioreactor with a developed microbiological predator-prey food chain are discussed. The presence of the predator microorganism completely changes the position and stability of the stationary states. A wide range of unstable steady states appears, associated with high amplitude oscillations of the state variables. Without automatic control such a system can only operate in transient states, with the yield undergoing periodic changes following the dynamics of the stable limit cycle. Technologically, this is undesirable. It has been shown that the oscillations can be removed by employing continuous P or PI controllers. Moreover, with a PI-controller, the predator can be eliminated from the system.
NASA Astrophysics Data System (ADS)
Dubbert, Maren; Kübert, Angelika; Cuntz, Matthias; Werner, Christiane
2015-04-01
Isotope techniques are widely applied in ecosystem studies. For example, isoflux models are used to separate soil evaporation from transpiration in ecosystems. These models often assume that plant transpiration occurs at isotopic steady state, i.e. that the transpired water shows the same isotopic signature as the source water. Yet, several studies found that transpiration did not occur at isotopic steady state, under both controlled and field conditions. Here we focused on identifying the internal and external factors which drive the isotopic signature of leaf transpiration. Using cavity ring-down spectroscopy (CRDS), the effect of both environmental variables and leaf physiological traits on δ18OT was investigated under controlled conditions. Six plant species with distinct leaf physiological traits were exposed to step changes in relative air humidity (RH), their response in δ18OT and gas exchange parameters and their leaf physiological traits were assessed. Moreover, two functionally distinct plant types (tree, i.e. Quercus suber, and grassland) of a semi-arid Mediterranean oak-woodland where observed under natural conditions throughout an entire growth period in the field. The species differed substantially in their leaf physiological traits and their turn-over times of leaf water. They could be grouped in species with fast (<60 min.), intermediate (ca. 120 min.) and slow (>240 min.) turn-over times, mostly due to differences in stomatal conductance, leaf water content or a combination of both. Changes in RH caused an immediate response in δ18OT, which were similarly strong in all species, while leaf physiological traits affected the subsequent response in δ18OT. The turn-over time of leaf water determined the speed of return to the isotopic steady or a stable δ18OT value (Dubbert & Kübert et al., in prep.). Under natural conditions, changes in environmental conditions over the diurnal cycle had a huge impact on the diurnal development of δ18OT in both
Steady states and global dynamics of electrical activity in the cerebral cortex
NASA Astrophysics Data System (ADS)
Robinson, P. A.; Rennie, C. J.; Wright, J. J.; Bourke, P. D.
1998-09-01
Steady states and global dynamics of electrical activity in the cerebral cortex are investigated within the framework of a recent continuum model. It is shown that for a particular physiologically realistic class of models, at most three steady states can occur, two of which are stable. The global dynamics of spatially uniform activity states is studied and it is shown that in a physiologically realistic class of models, the adiabatic dynamics is governed by a second-order differential equation equivalent to that for the motion of a Newtonian particle in a potential in the presence of friction. This result is used to derive a simplified dynamical equation in the friction-dominated limit. Solutions of these equations are compared with those of the full global dynamics equations and it is found that they are adequate for time scales longer than approximately 100 ms provided dendritic integration times are less than approximately 10 ms.
NASA Astrophysics Data System (ADS)
Bogoslovskiy, Nikita; Tsendin, Konstantin
2017-03-01
In the phase-change memory (PCM) crystallization occurs in the high-current filament which forms during switching to the conductive state. In the present paper we conduct a numerical modeling of the current filament formation dynamics in thin chalcogenide films using an electronic-thermal model based on negative-U centers tunnel ionization and Joule heating. The key role of inhomogeneities in the filament formation process is shown. Steady-state filament parameters were obtained from the analysis of the stationary heat conduction equation. The filament formation dynamics and the steady-state filament radius and temperature could be controlled by material parameters and contact resistance. Consequently it is possible to control the size of the region wherein crystallization occurs. A good agreement with numerous experimental data leads to the conclusion that thermal effects play a significant role in CGS conduction and high-current filament formation while switching.
A computer simulation using spreadsheets for learning concept of steady-state equilibrium
NASA Astrophysics Data System (ADS)
Sharda, Vandana; Sastri, O. S. K. S.; Bhardwaj, Jyoti; Jha, Arbind K.
2016-03-01
In this paper, we present a simple spreadsheet based simulation activity that can be performed by students at the undergraduate level. This simulation is implemented in free open source software (FOSS) LibreOffice Calc, which is available for both Windows and Linux platform. This activity aims at building the probability distribution for the possible macro-states of a system. This has been achieved by randomly sampling the configuration space consisting of all the possible microstates and determining the corresponding macrostate for each of the samples, which is akin to Monte-Carlo simulation. This simulation could act as a very useful tool in engaging students for learning the concepts of microstates, macrostates and steady state equilibrium, once the ideas have been introduced in the classroom. Further, the effect of the number of particles on the quality of steady state equilibrium achieved demonstrates the idea of thermodynamic limit.
Dynamic relaxation of a levitated nanoparticle from a non-equilibrium steady state.
Gieseler, Jan; Quidant, Romain; Dellago, Christoph; Novotny, Lukas
2014-05-01
Fluctuation theorems are a generalization of thermodynamics on small scales and provide the tools to characterize the fluctuations of thermodynamic quantities in non-equilibrium nanoscale systems. They are particularly important for understanding irreversibility and the second law in fundamental chemical and biological processes that are actively driven, thus operating far from thermal equilibrium. Here, we apply the framework of fluctuation theorems to investigate the important case of a system relaxing from a non-equilibrium state towards equilibrium. Using a vacuum-trapped nanoparticle, we demonstrate experimentally the validity of a fluctuation theorem for the relative entropy change occurring during relaxation from a non-equilibrium steady state. The platform established here allows non-equilibrium fluctuation theorems to be studied experimentally for arbitrary steady states and can be extended to investigate quantum fluctuation theorems as well as systems that do not obey detailed balance.
Steady and unsteady state thermal behaviour of triple concentric-tube heat exchanger
NASA Astrophysics Data System (ADS)
Boultif, Nora; Bougriou, Cherif
2017-03-01
This paper presents a numerical analysis by using the finite difference method to describe the steady and unsteady state thermal behavior of triple concentric-tube heat exchanger with parallel flow and counter flow arrangements. One gives the temperature variations of the three fluids and three walls with time along the triple concentric-tube heat exchanger. The fluids have a time lag and the response of triple concentric-tube heat exchanger in parallel flow configuration is faster than those of a counterflow arrangement, its performances are always lower than those of a counterflow triple concentric-tube heat exchanger. The heat transfer coefficients by convection of the three fluids vary with time in addition to the temperature and the heat exchanger performances are lower in unsteady state than the steady state case.
Steady state reconnection at a single 3D magnetic null point
NASA Astrophysics Data System (ADS)
Galsgaard, K.; Pontin, D. I.
2011-05-01
Aims: We systematically stress a rotationally symmetric 3D magnetic null point by advecting the opposite footpoints of the spine axis in opposite directions. This stress eventually concentrates in the vicinity of the null point, thereby forming a local current sheet through which magnetic reconnection takes place. The aim is to look for a steady state evolution of the current sheet dynamics, which may provide scaling relations for various characteristic parameters of the system. Methods: The evolution is followed by solving numerically the non-ideal MHD equations in a Cartesian domain. The null point is embedded in an initially constant density and temperature plasma. Results: It is shown that a quasi-steady reconnection process can be set up at a 3D null by continuous shear driving. It appears that a true steady state is unlikely to be realised because the current layer tends to grow until it is restricted by the geometry of the computational domain and the imposed driving profile. However, ratios between characteristic quantities clearly settle after some time to stable values, so that the evolution is quasi-steady. The experiments show a number of scaling relations, but they do not provide a clear consensus for extending to lower magnetic resistivity or faster driving velocities. More investigations are needed to fully clarify the properties of current sheets at magnetic null points.
NASA Astrophysics Data System (ADS)
Boulin, P. F.; Bretonnier, P.; Gland, N.
2010-12-01
Very low permeability geomaterials (order of nanoDarcy (10-21 m2)), such as clays rocks, are studied for many industrial applications such as production from unconventional reserves of oil and gas, CO2 geological storage and deep geological disposal of high-level long-lived nuclear wastes. For these last two applications, clay efficiency as barrier relies mainly on their very low permeability. Laboratory measurement of low permeability to water (below 10-19 m2) remains a technical challenge. Some authors argue that steady state methods are irrelevant due to the time required to stabilize water fluxes in such low permeability media. Most of the authors measuring low permeabilities use a transient technique called pulse decay. This study aims to compare objectively these different types of permeability tests performed on a single clay sample. For the steady state method, a high precision pump was used to impose a pressure gradient and to measure the small resulting water flow rate at steady state. We show that with a suitable set-up, the steady state method enables to measure a very low permeability of 8 10-22 m2 in a period of three days. For a comparable duration, the pulse decay test, most commonly used for such low permeability measurements, provides only an average estimate of the permeability. Permeability measurements by pulse decay require to perform simulations to interpret the pressure relaxation signals. Many uncertainties remain such as the determination of the reservoirs storage factor, micro leakage effect, or the determination of the initial pulse pressure. All these uncertainties have a very significant impact on the determination of sample permeability and specific storage. Opposite to the wide-spread idea that transient techniques are required to measure very low permeability, we show that direct steady state measurement of water permeability with suitable equipments can be much faster and more accurate than measurement by pulse decay, especially in
Steady-State Cycle Deck Launcher Developed for Numerical Propulsion System Simulation
NASA Technical Reports Server (NTRS)
VanDrei, Donald E.
1997-01-01
One of the objectives of NASA's High Performance Computing and Communications Program's (HPCCP) Numerical Propulsion System Simulation (NPSS) is to reduce the time and cost of generating aerothermal numerical representations of engines, called customer decks. These customer decks, which are delivered to airframe companies by various U.S. engine companies, numerically characterize an engine's performance as defined by the particular U.S. airframe manufacturer. Until recently, all numerical models were provided with a Fortran-compatible interface in compliance with the Society of Automotive Engineers (SAE) document AS681F, and data communication was performed via a standard, labeled common structure in compliance with AS681F. Recently, the SAE committee began to develop a new standard: AS681G. AS681G addresses multiple language requirements for customer decks along with alternative data communication techniques. Along with the SAE committee, the NPSS Steady-State Cycle Deck project team developed a standard Application Program Interface (API) supported by a graphical user interface. This work will result in Aerospace Recommended Practice 4868 (ARP4868). The Steady-State Cycle Deck work was validated against the Energy Efficient Engine customer deck, which is publicly available. The Energy Efficient Engine wrapper was used not only to validate ARP4868 but also to demonstrate how to wrap an existing customer deck. The graphical user interface for the Steady-State Cycle Deck facilitates the use of the new standard and makes it easier to design and analyze a customer deck. This software was developed following I. Jacobson's Object-Oriented Design methodology and is implemented in C++. The AS681G standard will establish a common generic interface for U.S. engine companies and airframe manufacturers. This will lead to more accurate cycle models, quicker model generation, and faster validation leading to specifications. The standard will facilitate cooperative work between
Zhang, Z Y; VanEtten, R L
1991-01-25
The complete time course of the hydrolysis of p-nitrophenyl phosphate catalyzed by the low molecular weight (acid) phosphotyrosyl protein phosphatase from bovine heart was elucidated and analyzed in detail. Burst titration kinetics were demonstrated for the first time with this class of enzyme. At pH 7.0, 4.5 degrees C, a transient pre-steady-state "burst" of p-nitrophenol was formed with a rate constant of 48 s-1. The burst was effectively stoichiometric and corresponded to a single enzyme active site/molecule. The burst was followed by a slow steady-state turnover of the phosphoenzyme intermediate with a rate constant of 1.2 s-1. Product inhibition studies indicated an ordered uni-bi kinetic scheme for the hydrolysis. Partition experiments conducted for several substrates revealed a constant product ratio. Vmax was constant for these substrates, and the overall rate of hydrolysis was increased greatly in the presence of alcohol acceptors. An enzyme-catalyzed 18O exchange between inorganic phosphate and water was detected and occurred with kcat = 4.47 x 10(-3) s-1 at pH 5.0, 37 degrees C. These results were all consistent with the existence of a phosphoenzyme intermediate in the catalytic pathway and with the breakdown of the intermediate being the rate-limiting step. The true Michaelis binding constant Ks = 6.0 mM, the apparent Km = 0.38 mM, and the rate constants for phosphorylation (k2 = 540 s-1) and dephosphorylation (k3 = 36.5 s-1) were determined under steady-state conditions with p-nitrophenyl phosphate at pH 5.0 and 37 degrees C in the presence of phosphate acceptors. The energies of activation for the enzyme-catalyzed hydrolysis at pH 5.0 and 7.0 were 13.6 and 14.1 kcal/mol, respectively. The activation energy for the enzyme-catalyzed medium 18O exchange between phosphate and water was 20.2 kcal/mol. Using the available equilibrium and rate constants, an energetic diagram was constructed for the enzyme-catalyzed reaction.
Steady states of solar coronal loops as nonaxisymmetric toroidal flux ropes
NASA Astrophysics Data System (ADS)
Sugiyama, Linda; Asgari-Targhi, M.
2016-10-01
Consistent MHD steady states for coronal loops on the surface of the sun, modeled as magnetic flux ropes, are derived for the first time, based on the equilibrium and stability of toroidal magnetically confined fusion plasmas. Coronal loops, like magnetic tori, are unstable to expansion in major radius. The solar gravity and plasma beta, previously ignored, are crucual parameters in the steady state. For loops with a predominantly axisymmetric magnetic axis, three analytical steady states exist in terms of beta and the normalized solar gravity parameter Ĝ = ga /vA2 , where g is the acceleration due to gravity, ordered in inverse aspect ratio: high beta (β ɛ) and small gravity Ĝ ɛ3 , which resembles a nearly axisymmetric high-beta tokamak, and high beta with larger Ĝ ɛ2 , and low beta (β ɛ2) with Ĝ ɛ3 , which are more strongly nonaxisymmetric. Comparison with observations shows that the two high beta states bracket the range of thin coronal loops in solar active regions ɛ 0.02 and Ĝ orders the loops by height. The low beta solution may describe certain thicker loops ɛ 0.1 that grow to solar flares or Coronal Mass Ejections. Work partially supported by the U.S. DOE OFES under Award DE-SC-0007883.
An analytical solution for the steady-state aerosol size distribution achieved in a steady-state, continuous flow chamber is derived, where particle growth is occurring by gas-to-particle conversion and particle loss is occurring by deposition to the walls of the chamber. The s...
Quantum transport in networks and photosynthetic complexes at the steady state.
Manzano, Daniel
2013-01-01
Recently, several works have analysed the efficiency of photosynthetic complexes in a transient scenario and how that efficiency is affected by environmental noise. Here, following a quantum master equation approach, we study the energy and excitation transport in fully connected networks both in general and in the particular case of the Fenna-Matthew-Olson complex. The analysis is carried out for the steady state of the system where the excitation energy is constantly "flowing" through the system. Steady state transport scenarios are particularly relevant if the evolution of the quantum system is not conditioned on the arrival of individual excitations. By adding dephasing to the system, we analyse the possibility of noise-enhancement of the quantum transport.
A periodogram-based method for the detection of steady-state visually evoked potentials.
Liavas, A P; Moustakides, G V; Henning, G; Psarakis, E Z; Husar, P
1998-02-01
The task of objective perimetry is to scan the visual field and find an answer about the function of the visual system. Flicker-burst stimulation--a physiological sensible combination of transient and steady-state stimulation--is used to generate deterministic sinusoidal responses or visually evoked potentials (VEP's) at the visual cortex, which are derived from the electroencephalogram by a suitable electrode array. In this paper we develop a new method for the detection of VEP's. Based on the periodogram of a time-series, we test the data for the presence of hidden periodic components, which correspond to steady-state VEP's. The method is applied successfully to real data.
Thermal-Conductivity Apparatus for Steady-State, Comparative Measurement of Ceramic Coatings.
Slifka, A J
2000-01-01
An apparatus has been developed to measure the thermal conductivity of ceramic coatings. Since the method uses an infrared microscope for temperature measurement, coatings as thin as 20 μm can, in principle, be measured using this technique. This steady-state, comparative measurement method uses the known thermal conductivity of the substrate material as the reference material for heat-flow measurement. The experimental method is validated by measuring a plasma-sprayed coating that has been previously measured using an absolute, steady-state measurement method. The new measurement method has a relative standard uncertainty of about 10 %. The measurement of the plasma-sprayed coating gives 0.58 W·m(-1)·K(-l) which compares well with the 0.62 W·m(-1)·K(-l) measured using the absolute method.
Implicit Total Variation Diminishing (TVD) schemes for steady-state calculations
NASA Technical Reports Server (NTRS)
Yee, H. C.; Warming, R. F.; Harten, A.
1983-01-01
The application of a new implicit unconditionally stable high resolution total variation diminishing (TVD) scheme to steady state calculations. It is a member of a one parameter family of explicit and implicit second order accurate schemes developed by Harten for the computation of weak solutions of hyperbolic conservation laws. This scheme is guaranteed not to generate spurious oscillations for a nonlinear scalar equation and a constant coefficient system. Numerical experiments show that this scheme not only has a rapid convergence rate, but also generates a highly resolved approximation to the steady state solution. A detailed implementation of the implicit scheme for the one and two dimensional compressible inviscid equations of gas dynamics is presented. Some numerical computations of one and two dimensional fluid flows containing shocks demonstrate the efficiency and accuracy of this new scheme.
NASA Technical Reports Server (NTRS)
Wang, Jai-Ching
1994-01-01
The lateral solute segregation that results from a curved solid-liquid interface shape during steady state unidirectional solidification of a binary alloy system has been studied both analytically and numerically by Coriell, Bosivert, Rehm, and Sekerka. The system under their study is a two dimensional rectangular system. However, most real growth systems are cylindrical systems. Thus, in a previous study, we have followed Coriell etc. formalism and obtained analytical results for lateral solute segregation for an azimuthal symmetric cylindrical binary melt system during steady state solidification process. The solid-liquid interface shape is expressed as a series combination of Bessel functions. In this study a computer program has been developed to simulate the lateral solute segregation.
Johnston, Matthew D
2015-06-01
It has been recently observed that the dynamical properties of mass action systems arising from many models of biochemical reaction networks can be characterized by considering the corresponding properties of a related generalized mass action system. The correspondence process known as network translation in particular has been shown to be useful in characterizing a system's steady states. In this paper, we further develop the theory of network translation with particular focus on a subclass of translations known as improper translations. For these translations, we derive conditions on the network topology of the translated network which are sufficient to guarantee the original and translated systems share the same steady states. We then present a mixed-integer linear programming algorithm capable of determining whether a mass action system can be corresponded to a generalized system through the process of network translation.
Iterative solutions to the steady-state density matrix for optomechanical systems
NASA Astrophysics Data System (ADS)
Nation, P. D.; Johansson, J. R.; Blencowe, M. P.; Rimberg, A. J.
2015-01-01
We present a sparse matrix permutation from graph theory that gives stable incomplete lower-upper preconditioners necessary for iterative solutions to the steady-state density matrix for quantum optomechanical systems. This reordering is efficient, adding little overhead to the computation, and results in a marked reduction in both memory and runtime requirements compared to other solution methods, with performance gains increasing with system size. Either of these benchmarks can be tuned via the preconditioner accuracy and solution tolerance. This reordering optimizes the condition number of the approximate inverse and is the only method found to be stable at large Hilbert space dimensions. This allows for steady-state solutions to otherwise intractable quantum optomechanical systems.
Comparison of steady-state and transient CVS cycle emission of an automotive Stirling engine
NASA Technical Reports Server (NTRS)
Farrell, R. A.; Bolton, R. J.
1983-01-01
The Automotive Stirling Engine Development Program is to demonstrate a number of goals for a Stirling-powered vehicle. These goals are related to an achievement of specified maximum emission rates, a combined cycle fuel economy 30 percent better than a comparable internal-combustion engine-powered automobile, multifuel capability, competitive cost and reliability, and a meeting of Federal standards concerning noise and safety. The present investigation is concerned with efforts related to meeting the stringent emission goals. Attention is given to the initial development of a procedure for predicting transient CVS urban cycle gaseous emissions from steady-state engine data, taking into account the employment of the test data from the first-generation automotive Stirling engine. A large amount of steady-state data from three Mod I automotive Stirling engines were used to predict urban CVS cycle emissions for the Mod I Lerma vehicle.
Steady-state visually evoked potentials: focus on essential paradigms and future perspectives.
Vialatte, François-Benoît; Maurice, Monique; Dauwels, Justin; Cichocki, Andrzej
2010-04-01
After 40 years of investigation, steady-state visually evoked potentials (SSVEPs) have been shown to be useful for many paradigms in cognitive (visual attention, binocular rivalry, working memory, and brain rhythms) and clinical neuroscience (aging, neurodegenerative disorders, schizophrenia, ophthalmic pathologies, migraine, autism, depression, anxiety, stress, and epilepsy). Recently, in engineering, SSVEPs found a novel application for SSVEP-driven brain-computer interface (BCI) systems. Although some SSVEP properties are well documented, many questions are still hotly debated. We provide an overview of recent SSVEP studies in neuroscience (using implanted and scalp EEG, fMRI, or PET), with the perspective of modern theories about the visual pathway. We investigate the steady-state evoked activity, its properties, and the mechanisms behind SSVEP generation. Next, we describe the SSVEP-BCI paradigm and review recently developed SSVEP-based BCI systems. Lastly, we outline future research directions related to basic and applied aspects of SSVEPs.
Liu, H. H.
2010-09-15
Optimality principles have been used for investigating physical processes in different areas. This work attempts to apply an optimal principle (that water flow resistance is minimized on global scale) to steady-state unsaturated flow processes. Based on the calculus of variations, we show that under optimal conditions, hydraulic conductivity for steady-state unsaturated flow is proportional to a power function of the magnitude of water flux. This relationship is consistent with an intuitive expectation that for an optimal water flow system, locations where relatively large water fluxes occur should correspond to relatively small resistance (or large conductance). Similar results were also obtained for hydraulic structures in river basins and tree leaves, as reported in other studies. Consistence of this theoretical result with observed fingering-flow behavior in unsaturated soils and an existing model is also demonstrated.
Thermal-Conductivity Apparatus for Steady-State, Comparative Measurement of Ceramic Coatings
Slifka, A. J.
2000-01-01
An apparatus has been developed to measure the thermal conductivity of ceramic coatings. Since the method uses an infrared microscope for temperature measurement, coatings as thin as 20 μm can, in principle, be measured using this technique. This steady-state, comparative measurement method uses the known thermal conductivity of the substrate material as the reference material for heat-flow measurement. The experimental method is validated by measuring a plasma-sprayed coating that has been previously measured using an absolute, steady-state measurement method. The new measurement method has a relative standard uncertainty of about 10 %. The measurement of the plasma-sprayed coating gives 0.58 W·m−1·K−l which compares well with the 0.62 W·m−1·K−l measured using the absolute method. PMID:27551628
Effect of transverse magnetic field on the steady state properties of Plasma Diodes
NASA Astrophysics Data System (ADS)
Pramanik, Sourav; Kuznetsov, Victor; Chakrabarti, Nikhil
2016-10-01
A study of the steady-states of the Plasma Diodes (e.g., Bursian diode, Pierce diode etc.) driven by a cold electron beam is presented in presence of an external transverse magnetic field is presented. Both the regimes of no electron-reflection and electron-reflection are taken into account. Steady state solutions are evaluated using emitter electric field as a characteristic parameters, for fixed values of the diode length, applied voltage, and magnetic field strength. For our purpose, both the Eulerian and Lagrangian descriptions are employed. It is shown that transverse magnetic field has profound influences on the space charge limit, maximum diode current, aperiodic instability and other characteristic parameters. An external magnetic field can be used to design fast electronic switches based on its effects on the Plasma diode.
Diagnostics and control for the steady state and pulsed tokamak DEMO
NASA Astrophysics Data System (ADS)
Orsitto, F. P.; Villari, R.; Moro, F.; Todd, T. N.; Lilley, S.; Jenkins, I.; Felton, R.; Biel, W.; Silva, A.; Scholz, M.; Rzadkiewicz, J.; Duran, I.; Tardocchi, M.; Gorini, G.; Morlock, C.; Federici, G.; Litnovsky, A.
2016-02-01
The present paper is devoted to a first assessment of the DEMO diagnostics systems and controls in the context of pulsed and steady state reactor design under study in Europe. In particular, the main arguments treated are: (i) The quantities to be measured in DEMO and the requirements for the measurements; (ii) the present capability of the diagnostic and control technology, determining the most urgent gaps, and (iii) the program and strategy of the research and development (R&D) needed to fill the gaps. Burn control, magnetohydrodynamic stability, and basic machine protection require improvements to the ITER technology, and moderated efforts in R&D can be dedicated to infrared diagnostics (reflectometry, electron cyclotron emission, polarimetry) and neutron diagnostics. Metallic Hall sensors appear to be a promising candidate for magnetic measurements in the high neutron fluence and long/steady state discharges of DEMO.
Non-steady-state operation of polymer/TiO2 photovoltaic devices
NASA Astrophysics Data System (ADS)
Kirov, Kiril R.; Burlakov, Victor M.; Xie, Zhibin; Henry, Bernard M.; Carey, Michelle J.; Grovenor, Christopher R. M.; Burn, Paul L.; Assender, Hazel E.; Briggs, G. Andrew D.
2004-11-01
We present data on the initial period of operation of Gilch-route MEH-PPV/TiO2 composite solar cells (CSCs) which show that during this period the CSCs operate in a non-steady state regime. The behavior is complex and may include a gradual rise of the open circuit voltage (Voc) and of the short-circuit current density (Jsc) with time, a passage through a maximum of either or both parameters, and even a sign reversal. The mechanisms most probably contributing to the transient processes are: i) diffusion driven redistribution of charges resulting in the build up of a quasi steady state charge density profile across the device; ii) photo-doping resulting in a relatively slow increase of the average charge carrier concentration and consequently of the conductivity of the device. The latter is responsible for a strong decrease in Voc, and is evidenced by the significant increase in dark current after device illumination.
Steady-state EB cap size fluctuations are determined by stochastic microtubule growth and maturation
Rickman, Jamie; Duellberg, Christian; Cade, Nicholas I.; Griffin, Lewis D.; Surrey, Thomas
2017-01-01
Growing microtubules are protected from depolymerization by the presence of a GTP or GDP/Pi cap. End-binding proteins of the EB1 family bind to the stabilizing cap, allowing monitoring of its size in real time. The cap size has been shown to correlate with instantaneous microtubule stability. Here we have quantitatively characterized the properties of cap size fluctuations during steady-state growth and have developed a theory predicting their timescale and amplitude from the kinetics of microtubule growth and cap maturation. In contrast to growth speed fluctuations, cap size fluctuations show a characteristic timescale, which is defined by the lifetime of the cap sites. Growth fluctuations affect the amplitude of cap size fluctuations; however, cap size does not affect growth speed, indicating that microtubules are far from instability during most of their time of growth. Our theory provides the basis for a quantitative understanding of microtubule stability fluctuations during steady-state growth. PMID:28280102
Realization of minute-long steady-state H-mode discharges on EAST
NASA Astrophysics Data System (ADS)
Xianzu, GONG; Baonian, WAN; Jiangang, LI; Jinping, QIAN; Erzhong, LI; Fukun, LIU; Yanping, ZHAO; Mao, WANG; Handong, XU; A, M. GAROFALO; Annika, EKEDAH; Siye, DING; Juan, HUANG; Ling, ZHANG; Qing, ZANG; Haiqing, LIU; Long, ZENG; Shiyao, LIN; Biao, SHEN; Bin, ZHANG; Linming, SHAO; Bingjia, XIAO; Jiansheng, HU; Chundong, HU; Liqun, HU; Liang, WANG; Youwen, SUN; Guosheng, XU; Yunfeng, LIANG; Nong, XIANG; EAST Team
2017-03-01
In the 2016 EAST experimental campaign, a steady-state long-pulse H-mode discharge with an ITER-like tungsten divertor lasting longer than one minute has been obtained using only RF heating and current drive, through an integrated control of the wall conditioning, plasma configuration, divertor heat flux, particle exhaust, impurity management, and effective coupling of multiple RF heating and current drive sources at high injected power. The plasma current (I p ∼ 0.45 MA) was fully-noninductively driven (V loop < 0.0 V) by a combination of ∼2.5 MW LHW, ∼0.4 MW ECH and ∼0.8 MW ICRF. This result demonstrates the progress of physics and technology studies on EAST, and will benefit the physics basis for steady state operation of ITER and CFETR.
Steady-State Somatosensory Evoked Potential for Brain-Computer Interface—Present and Future
Ahn, Sangtae; Kim, Kiwoong; Jun, Sung Chan
2016-01-01
Brain-computer interface (BCI) performance has achieved continued improvement over recent decades, and sensorimotor rhythm-based BCIs that use motor function have been popular subjects of investigation. However, it remains problematic to introduce them to the public market because of their low reliability. As an alternative resolution to this issue, visual-based BCIs that use P300 or steady-state visually evoked potentials (SSVEPs) seem promising; however, the inherent visual fatigue that occurs with these BCIs may be unavoidable. For these reasons, steady-state somatosensory evoked potential (SSSEP) BCIs, which are based on tactile selective attention, have gained increasing attention recently. These may reduce the fatigue induced by visual attention and overcome the low reliability of motor activity. In this literature survey, recent findings on SSSEP and its methodological uses in BCI are reviewed. Further, existing limitations of SSSEP BCI and potential future directions for the technique are discussed. PMID:26834611
PEBBLE: a two-dimensional steady-state pebble bed reactor thermal hydraulics code
Vondy, D.R.
1981-09-01
This report documents the local implementation of the PEBBLE code to treat the two-dimensional steady-state pebble bed reactor thermal hydraulics problem. This code is implemented as a module of a computation system used for reactor core history calculations. Given power density data, the geometric description in (RZ), and basic heat removal conditions and thermal properties, the coolant properties, flow conditions, and temperature distributions in the pebble fuel elements are predicted. The calculation is oriented to the continuous fueling, steady state condition with consideration of the effect of the high energy neutron flux exposure and temperature history on the thermal conductivity. The coolant flow conditions are calculated for the same geometry as used in the neutronics calculation, power density and fluence data being used directly, and temperature results are made available for subsequent use.
Composing Problem Solvers for Simulation Experimentation: A Case Study on Steady State Estimation
Leye, Stefan; Ewald, Roland; Uhrmacher, Adelinde M.
2014-01-01
Simulation experiments involve various sub-tasks, e.g., parameter optimization, simulation execution, or output data analysis. Many algorithms can be applied to such tasks, but their performance depends on the given problem. Steady state estimation in systems biology is a typical example for this: several estimators have been proposed, each with its own (dis-)advantages. Experimenters, therefore, must choose from the available options, even though they may not be aware of the consequences. To support those users, we propose a general scheme to aggregate such algorithms to so-called synthetic problem solvers, which exploit algorithm differences to improve overall performance. Our approach subsumes various aggregation mechanisms, supports automatic configuration from training data (e.g., via ensemble learning or portfolio selection), and extends the plugin system of the open source modeling and simulation framework James II. We show the benefits of our approach by applying it to steady state estimation for cell-biological models. PMID:24705453
Steady-State Dynamic Behavior of a Flexible Rotor With Auxiliary Support From a Clearance Bearing
NASA Technical Reports Server (NTRS)
Xie, Huajun; Flowers, George T.; Feng, Li; Lawrence, Charles T.
1996-01-01
This paper investigates the steady-state responses of a rotor system supported by auxiliary bearings in which there is a clearance between the rotor and the inner race of the bearing. A simulation model based upon the rotor of a production jet engine is developed and its steady-state behavior is explored over a wide range of operating conditions for various parametric configurations. Specifically, the influence of rotor imbalance, clearance, support stiffness and damping is studied. Bifurcation diagrams are used as a tool to examine the dynamic behavior of this system as a function of the afore mentioned parameters. The harmonic balance method is also employed for synchronous response cases. The observed dynamical responses is discussed and some insights into the behavior of such systems are presented.
Steady-state mechanical squeezing in a double-cavity optomechanical system
Wang, Dong-Yang; Bai, Cheng-Hua; Wang, Hong-Fu; Zhu, Ai-Dong; Zhang, Shou
2016-01-01
We study the physical properties of double-cavity optomechanical system in which the mechanical resonator interacts with one of the coupled cavities and another cavity is used as an auxiliary cavity. The model can be expected to achieve the strong optomechanical coupling strength and overcome the optomechanical cavity decay, simultaneously. Through the coherent auxiliary cavity interferences, the steady-state squeezing of mechanical resonator can be generated in highly unresolved sideband regime. The validity of the scheme is assessed by numerical simulation and theoretical analysis of the steady-state variance of the mechanical displacement quadrature. The scheme provides a platform for the mechanical squeezing beyond the resolved sideband limit and solves the restricted experimental bounds at present. PMID:27917939
Steady-state boundary lubrication with formulated C-ethers to 260 C
NASA Technical Reports Server (NTRS)
Loomis, W. R.
1981-01-01
Steady state wear and friction studies were made at boundary lubrication conditions in a pin on disk (pure iron on rotating CVM M 50 steel) sliding friction apparatus with five C ether formulated fluids (modified polyphenyl ether containing phosphrous ester, organic acid, and other additives). Conditions included 20, 150, and 260 C disk temperatures, dry air test atmosphere, 1 kilogram load, 50 rpm disk speed, and test times to 130 minutes. Results were compared with those obtained with a formulated MIL L 27502 candidate ester and the C ether base fluid. Three of the C ether formulations gave better lubrication than both reference fluids under most conditions. The other two C ether formulations yielded higher wear rates and friction coefficients than the C ether base fluid for most of the temperature range. Only one C ether formulation showed consistently higher steady state wear rates than the ester.
Nonequilibrium density-matrix description of steady-state quantum transport.
Dhar, Abhishek; Saito, Keiji; Hänggi, Peter
2012-01-01
With this work we investigate the stationary nonequilibrium density matrix of current carrying nonequilibrium steady states of in-between quantum systems that are connected to reservoirs. We describe the analytical procedure to obtain the explicit result for the reduced density matrix of quantum transport when the system, the connecting reservoirs, and the system-reservoir interactions are described by quadratic Hamiltonians. Our procedure is detailed for both electronic transport described by the tight-binding Hamiltonian and for phonon transport described by harmonic Hamiltonians. For the special case of weak system-reservoir couplings, a more detailed description of the steady-state density matrix is obtained. Several paradigm transport setups for interelectrode electron transport and low-dimensional phonon heat flux are elucidated.
Kabir, M. Z.; Imam, Safayat-Al
2013-04-15
A theoretical model for describing bias-dependent transient and steady-state behaviors of dark current in amorphous selenium (a-Se) avalanche detector structures has been developed. The analytical model considers bulk thermal generation current from mid-gap sates, transient carrier depletion, and carrier injection from the electrodes incorporating avalanche multiplication. The proposed physics-based dark current model is compared with the published experimental results on three potential a-Se avalanche detector structures. The steady-state dark current is the minimum for the structures that have effective blocking layers for both holes and electrons. The transient decay time to reach a plateau decreases considerably with increasing electric field.
The Medical Education Commission Report 2002: trends indicate a steady state supply of physicians.
Rigby, Perry G; Foulks, Edward; Pinsky, William W; Braun, Kurt; Hilton, Charles; Guidry, Jimmy
2002-01-01
This summary report for 2002 provides the detailed and updated data on all Graduate Medical Education (GME) residents and fellows in Louisiana for the last academic year. The 2002 match results and the trend in matching over the last 4 years depict the consistent successful match by Louisiana institutions. The totals and components of GME in Louisiana are steady. The infusion of gradually increasing numbers of physicians over the last 30 years in the United States and in Louisiana is quantified to indicate the present consistent steady state production and supply. The ripple effect into the physician population of this infusion now shows the expected beginning stabilization, although incomplete at this juncture. While demand for physician services for healthcare delivery is difficult to define and quantify, the inexorable increase of utilization of healthcare services portends a future mismatch of supply and demand, a shortage not a surplus.
Non-steady-state transport of superthermal electrons in the plasmasphere
NASA Technical Reports Server (NTRS)
Khazanov, George V.; Liemohn, Michael W.; Gombosi, Tamas I.; Nagy, Andrew F.
1993-01-01
Numerical solutions to the time-dependent kinetic equation, which describes the transport of superthermal electrons in the splasmasphere between the two conjugate ionospheres, are presented. The model calculates the distribution function as a function of time, field-aligned distance, energy, and pitch-angle. The processes of refilling, depleting, and establishing steady-state conditions of superthermal electrons in the plasmasphere are discussed.
Chirality, causality, and fluctuation-dissipation theorems in nonequilibrium steady states.
Wang, Chenjie; Feldman, D E
2013-01-18
Edges of some quantum Hall liquids and a number of other systems exhibit chiral transport: excitations can propagate in one direction only, e.g., clockwise. We derive a family of fluctuation-dissipation relations in nonequilibrium steady states of such chiral systems. The theorems connect nonlinear response with fluctuations far from thermal equilibrium and hold only in case of chiral transport. They can be used to test the chiral or nonchiral character of the system.
Restitution slope is principally determined by steady-state action potential duration.
Shattock, Michael J; Park, Kyung Chan; Yang, Hsiang-Yu; Lee, Angela Wc; Niederer, Steve; MacLeod, Kenneth T; Winter, James
2017-03-23
AimsThe steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition of the apparent association between steady-state APD and the slope of the restitution curve. The objective of this study was to test the hypothesis that restitution slope is determined by APD and to examine the relationship between restitution slope, refractoriness and susceptibility to VF.Methods and ResultsExperiments were conducted in isolated hearts and ventricular myocytes from adult guinea pigs and rabbits. Restitution curves were measured under control conditions and following intervention to prolong (clofilium, veratridine, bretylium, low [Ca]e, chronic transverse aortic constriction) or shorten (catecholamines, rapid pacing) ventricular APD. Despite markedly differing mechanisms of action, all interventions that prolonged the action potential led to a steepening of the restitution curve (and vice versa). Normalising the restitution curve as a % of steady-state APD abolished the difference in restitution curves by all interventions. Altered restitution dynamics were preserved when APD was modulated by current injection in myocytes pre-treated with the calcium chelator BAPTA-AM, to abolish the intracellular calcium transient. The non-linear relation between APD and the rate of repolarization of the action potential is shown to underpin the common influence of APD on the slope of the restitution curve. Susceptibility to VF was found to parallel changes in APD/refractoriness, rather than restitution slope.Conclusion(s)Steady-state APD is the principal determinant of the slope of the ventricular electrical restitution curve. In the absence of post-repolarization refractoriness, factors that prolong the action potential would be expected to steepen the restitution curve. However, concomitant changes in tissue refractoriness act to reduce
Pilyugina, Svetlana A; Fischbein, Nancy J; Liao, Y Joyce; McCulley, Timothy J
2007-06-01
An otherwise healthy 12-month-old girl presented for evaluation of reduced abduction of the left eye detected at 6 months of age. The remainder of the examination was unremarkable. A special MRI sequence-fast imaging employing steady-state acquisition (FIESTA)-visualized the right but not the left sixth nerve cisternal segment. This is the first reported use of the MRI FIESTA sequence to diagnose aplasia of the sixth cranial nerve.
Steady-state and dynamic models of unified power flow controller (UPFC) for power system studies
Nabavi-Niaki, A.; Iravani, M.R.
1996-11-01
This paper provides comprehensive development procedures and final forms of mathematical models of unified power flow controller (UPFC) for steady-state, transient stability and eigenvalue studies. Based on the developed models, the impacts of control strategy, parameters and location of UPFC on power system operating conditions are discussed. The accuracy of the developed models is verified through comparing the study results with those obtained from detailed time-domain simulation using the Electromagnetic Transients Program (EMTP).
GENERAL: Steady State Entanglement and Saturation Effects in Correlated Spontaneous Emission Lasers
NASA Astrophysics Data System (ADS)
Wang, Fei; Hu, Xiang-Ming; Shi, Wen-Xing
2009-08-01
It has recently been shown that correlated spontaneous emission lasers (CEL) exhibit transient entanglement in the linear regime. Here we re-examine the quantum correlations in two-photon CEL and explore the saturation effects on continuous variable entanglement. It is shown that the steady state entanglement is obtainable in the weak or moderate saturation regime, while is washed out in the deep saturation regime.
Cooperative Effects in Models of Steady-State Transport across Membranes
Hill, Terrell L.; Chen, Yi-Der
1971-01-01
Several different one-site, two-site, and multisite models of steady-state ion transport across a membrane are investigated. The basic features, including cooperative interactions between channels, are the same as in earlier papers in this series. In particular, the present paper represents a considerable elaboration of part III. The models might apply to artificial or possibly to biological membranes, but particular applications must await further elucidation of the molecular structure and operation of these membranes. PMID:5132496
Agarwalla, Bijay Kumar; Li, Baowen; Wang, Jian-Sheng
2012-05-01
We study the statistics of heat transferred in a given time interval t_{M}, through a finite harmonic chain, called the center, which is connected to two heat baths, the left (L) and the right (R), that are maintained at two temperatures. The center atoms are driven by external time-dependent forces. We calculate the cumulant generating function (CGF) for the heat transferred out of the left lead, Q_{L}, based on the two-time quantum measurement concept and using the nonequilibrium Green's function method. The CGF can be concisely expressed in terms of Green's functions of the center and an argument-shifted self-energy of the lead. The expression of the CGF is valid in both transient and steady-state regimes. We consider three initial conditions for the density operator and show numerically, for a one-atom junction, how their transient behaviors differ from each other but, finally, approach the same steady state, independent of the initial distributions. We also derive the CGF for the joint probability distribution P(Q_{L},Q_{R}), and discuss the correlations between Q_{L} and Q_{R}. We calculate the CGF for total entropy production in the reservoirs. In the steady state we explicitly show that the CGFs obey steady-state fluctuation theorems. We obtain classical results by taking ℏ→0. We also apply our method to the counting of the electron number and electron energy, for which the associated self-energy is obtained from the usual lead self-energy by multiplying a phase and shifting the contour time, respectively.
Infinite product expansion of the Fokker–Planck equation with steady-state solution
Martin, R. J.; Craster, R. V.; Kearney, M. J.
2015-01-01
We present an analytical technique for solving Fokker–Planck equations that have a steady-state solution by representing the solution as an infinite product rather than, as usual, an infinite sum. This method has many advantages: automatically ensuring positivity of the resulting approximation, and by design exactly matching both the short- and long-term behaviour. The efficacy of the technique is demonstrated via comparisons with computations of typical examples. PMID:26346100
Crank inertial load has little effect on steady-state pedaling coordination.
Fregly, B J; Zajac, F E; Dairaghi, C A
1996-12-01
Inertial load can affect the control of a dynamic system whenever parts of the system are accelerated or decelerated. During steady-state pedaling, because within-cycle variations in crank angular acceleration still exist, the amount of crank inertia present (which varies widely with road-riding gear ratio) may affect the within-cycle coordination of muscles. However, the effect of inertial load on steady-state pedaling coordination is almost always assumed to be negligible, since the net mechanical energy per cycle developed by muscles only depends on the constant cadence and workload. This study test the hypothesis that under steady-state conditions, the net joint torques produced by muscles at the hip, knee, and ankle are unaffected by crank inertial load. To perform the investigation, we constructed a pedaling apparatus which could emulate the low inertial load of a standard ergometer or the high inertial load of a road bicycle in high gear. Crank angle and bilateral pedal force and angle data were collected from ten subjects instructed to pedal steadily (i.e., constant speed across cycles) and smoothly (i.e., constant speed within a cycle) against both inertias at a constant workload. Virtually no statistically significant changes were found in the net hip and knee muscle joint torques calculated from an inverse dynamics analysis. Though the net ankle muscle joint torque, as well as the one- and two-legged crank torque, showed statistically significant increases at the higher inertia, the changes were small. In contrast, large statistically significant reductions were found in crank kinematic variability both within a cycle and between cycles (i.e., cadence), primarily because a larger inertial load means a slower crank dynamic response. Nonetheless, the reduction in cadence variability was somewhat attenuated by a large statistically significant increase in one-legged crank torque variability. We suggest, therefore, that muscle coordination during steady-state
Estimating equations for biomarker based exposure estimation under non-steady-state conditions.
Bartell, Scott M; Johnson, Wesley O
2011-06-13
Unrealistic steady-state assumptions are often used to estimate toxicant exposure rates from biomarkers. A biomarker may instead be modeled as a weighted sum of historical time-varying exposures. Estimating equations are derived for a zero-inflated gamma distribution for daily exposures with a known exposure frequency. Simulation studies suggest that the estimating equations can provide accurate estimates of exposure magnitude at any reasonable sample size, and reasonable estimates of the exposure variance at larger sample sizes.
Tromberg, Bruce J.; Berger, Andrew J.; Cerussi, Albert E.; Bevilacqua, Frederic; Jakubowski, Dorota
2008-09-23
A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.
Silva, J P; Almeida, Y B; Pinheiro, I O; Knoelchelmann, A; Silva, J M F
2015-02-01
In recent decades, the production of compounds from microorganisms has increased significantly. Glycerol as a source of substrate appears to have great potential, due to its large supply because of the increase in biodiesel production. This paper will discuss the multiplicity of steady states for the production of 1,3-propanediol from glycerol by Clostridium butyricum, employing a model that takes into account inhibition by fermentation products. The theoretical study of bifurcation enabled us to make a qualitative adjustment to the various experimental steady states, using the theoretical steady states obtained from the AUTO2007 program. The theoretical model parameters were varied to fit qualitatively the values of the experimental steady states. In addition, this work is a qualitative study, using experimental steady states that can be used as an initial study for more advanced work on optimizing the production of 1,3-propanediol.
Analytical comparison of transient and steady state visual evoked cortical potentials
NASA Technical Reports Server (NTRS)
Junker, A. M.; Kenner, K. M.; Kleinman, D. L.; Mcclurg, T. D.
1986-01-01
To better describe the linear-dynamic properties of the human visual-cortical response system, transient and steady state Visual Evoked Response Potentials (VERP) were observed. The stimulus presentation device provided both the evoking stimulus (flickering or pulsing lights) and a video task display. The steady state stimulus was modulated by a complex, ten frequency, sum-of-sines, wave. The transient VERP was the time-locked average of the EEG to a series of narrow light pulses (pulse width of 10 msec). The Fourier transform of the averaged pulses had properties that approximate band limited white noise, i.e., a flat spectrum over the frequency region spanned by the 10 summed sines. The Fourier transform of both the steady state and the transient evoked potentials resulted in transfer that are equivalent and therefore comparable. To investigate the effects of task loading on evoked potentials, a grammatical reasoning task was provided. Results support the relevancy of continued application of a systems engineering approach for describing neurosensory functioning.
A waved journal bearing concept with improved steady-state and dynamic performance
NASA Technical Reports Server (NTRS)
Dimofte, Florin
1994-01-01
Analysis of the waved journal bearing concept featuring a waved inner bearing diameter for use with a compressible lubricant (gas) is presented. A three wave, waved journal bearing geometry is used to show the geometry of this concept. The performance of generic waved bearings having either three, four, six, or eight waves is predicted for air lubricated bearings. Steady-state performance is discussed in terms of bearing load capacity, while the dynamic performance is discussed in terms of dynamic coefficients and fluid film stability. It was found that the bearing wave amplitude has an important influence on both steady-state and dynamic performance of the waved journal bearing. For a fixed eccentricity ratio, the bearing steady-state load capacity and direct dynamic stiffness coefficient increase as the wave amplitude increases. Also, the waved bearing becomes more stable as the wave amplitude increases. In addition, increasing the number of waves reduces the waved bearing's sensitivity to the direction of the applied load relative to the wave. However, the range in which the bearing performance can be varied decreases as the number of waves increases. Therefore, both the number and the amplitude of the waves must be properly selected to optimize the waved bearing design for a specific application. It is concluded that the stiffness of an air bearing, due to the hydrodynamic effect, could be doubled and made to run stably by using a six or eight wave geometry with a wave amplitude approximately half of the bearing radial clearance.
Shim, Jaesool; Yoo, Kisoo; Dutta, Prashanta
2017-03-01
The determination of an analytical solution to find the steady-state protein concentration distribution in IEF is very challenging due to the nonlinear coupling between mass and charge conservation equations. In this study, approximate analytical solutions are obtained for steady-state protein distribution in carrier ampholyte based IEF. Similar to the work of Svensson, the final concentration profile for proteins is assumed to be Gaussian, but appropriate expressions are presented in order to obtain the effective electric field and pH gradient in the focused protein band region. Analytical results are found from iterative solutions of a system of coupled algebraic equations using only several iterations for IEF separation of three plasma proteins: albumin, cardiac troponin I, and hemoglobin. The analytical results are compared with numerically predicted results for IEF, showing excellent agreement. Analytically obtained electric field and ionic conductivity distributions show significant deviation from their nominal values, which is essential in finding the protein focusing behavior at isoelectric points. These analytical solutions can be used to determine steady-state protein concentration distribution for experiment design of IEF considering any number of proteins and ampholytes. Moreover, the model presented herein can be used to find the conductivity, electric field, and pH field.
Exploration of trade-offs between steady-state and dynamic properties in signaling cycles
NASA Astrophysics Data System (ADS)
Radivojevic, A.; Chachuat, B.; Bonvin, D.; Hatzimanikatis, V.
2012-08-01
In the intracellular signaling networks that regulate important cell processes, the base pattern comprises the cycle of reversible phosphorylation of a protein, catalyzed by kinases and opposing phosphatases. Mathematical modeling and analysis have been used for gaining a better understanding of their functions and to capture the rules governing system behavior. Since biochemical parameters in signaling pathways are not easily accessible experimentally, it is necessary to explore possibilities for both steady-state and dynamic responses in these systems. While a number of studies have focused on analyzing these properties separately, it is necessary to take into account both of these responses simultaneously in order to be able to interpret a broader range of phenotypes. This paper investigates the trade-offs between optimal characteristics of both steady-state and dynamic responses. Following an inverse sensitivity analysis approach, we use systematic optimization methods to find the biochemical and biophysical parameters that simultaneously achieve optimal steady-state and dynamic performance. Remarkably, we find that even a single covalent modification cycle can simultaneously and robustly achieve high ultrasensitivity, high amplification and rapid signal transduction. We also find that the response rise and decay times can be modulated independently by varying the activating- and deactivating-enzyme-to-interconvertible-protein ratios.
Effects of aging in catastrophe on the steady state and dynamics of a microtubule population
NASA Astrophysics Data System (ADS)
Jemseena, V.; Gopalakrishnan, Manoj
2015-05-01
Several independent observations have suggested that the catastrophe transition in microtubules is not a first-order process, as is usually assumed. Recent in vitro observations by Gardner et al. [M. K. Gardner et al., Cell 147, 1092 (2011), 10.1016/j.cell.2011.10.037] showed that microtubule catastrophe takes place via multiple steps and the frequency increases with the age of the filament. Here we investigate, via numerical simulations and mathematical calculations, some of the consequences of the age dependence of catastrophe on the dynamics of microtubules as a function of the aging rate, for two different models of aging: exponential growth, but saturating asymptotically, and purely linear growth. The boundary demarcating the steady-state and non-steady-state regimes in the dynamics is derived analytically in both cases. Numerical simulations, supported by analytical calculations in the linear model, show that aging leads to nonexponential length distributions in steady state. More importantly, oscillations ensue in microtubule length and velocity. The regularity of oscillations, as characterized by the negative dip in the autocorrelation function, is reduced by increasing the frequency of rescue events. Our study shows that the age dependence of catastrophe could function as an intrinsic mechanism to generate oscillatory dynamics in a microtubule population, distinct from hitherto identified ones.
Ion-selective supported liquid membranes placed under steady-state diffusion control.
Tompa, Károly; Birbaum, Karin; Malon, Adam; Vigassy, Tamás; Bakker, Eric; Pretsch, Ernö
2005-12-01
Supported liquid membranes are used here to establish steady-state concentration profiles across ion-selective membranes rapidly and reproducibly. This opens up new avenues in the area of nonequilibrium potentiometry, where reproducible accumulation and depletion processes at ion-selective membranes may be used to gain valuable analytical information about the sample. Until today, drifting signals originating from a slowly developing concentration profile across the ion-selective membrane made such approaches impractical in zero current potentiometry. Here, calcium- and silver-selective membranes were placed between two identical aqueous electrolyte solutions, and the open circuit potential was monitored upon changing the composition of one solution. Steady state was reached in approximately 1 min with 25-microm porous polypropylene membranes filled with bis(2-ethylhexyl) sebacate doped with ionophore and lipophilic ion exchanger. Ion transport across the membrane resulted on the basis of nonsymmetric ion-exchange processes at both membrane sides. The steady-state potential was calculated as the sum of the two membrane phase boundary potentials, and good correspondence to experiment was observed. Concentration polarizations in the contacting aqueous phases were confirmed with stirring experiments. It was found that interferences (barium in the case of calcium electrodes and potassium with silver electrodes) induce a larger potential change than expected with the Nicolsky equation because they influence the level of polarization of the primary ion (calcium or silver) that remains potential determining.
Steady-state propagation speed of rupture fronts along one-dimensional frictional interfaces
NASA Astrophysics Data System (ADS)
Amundsen, David Skâlid; Trømborg, Jørgen Kjoshagen; Thøgersen, Kjetil; Katzav, Eytan; Malthe-Sørenssen, Anders; Scheibert, Julien
2015-09-01
The rupture of dry frictional interfaces occurs through the propagation of fronts breaking the contacts at the interface. Recent experiments have shown that the velocities of these rupture fronts range from quasistatic velocities proportional to the external loading rate to velocities larger than the shear wave speed. The way system parameters influence front speed is still poorly understood. Here we study steady-state rupture propagation in a one-dimensional (1D) spring-block model of an extended frictional interface for various friction laws. With the classical Amontons-Coulomb friction law, we derive a closed-form expression for the steady-state rupture velocity as a function of the interfacial shear stress just prior to rupture. We then consider an additional shear stiffness of the interface and show that the softer the interface, the slower the rupture fronts. We provide an approximate closed form expression for this effect. We finally show that adding a bulk viscosity on the relative motion of blocks accelerates steady-state rupture fronts and we give an approximate expression for this effect. We demonstrate that the 1D results are qualitatively valid in 2D. Our results provide insights into the qualitative role of various key parameters of a frictional interface on its rupture dynamics. They will be useful to better understand the many systems in which spring-block models have proved adequate, from friction to granular matter and earthquake dynamics.
NASA Astrophysics Data System (ADS)
Hu, J. S.; Sun, Z.; Guo, H. Y.; Li, J. G.; Wan, B. N.; Wang, H. Q.; Ding, S. Y.; Xu, G. S.; Liang, Y. F.; Mansfield, D. K.; Maingi, R.; Zou, X. L.; Wang, L.; Ren, J.; Zuo, G. Z.; Zhang, L.; Duan, Y. M.; Shi, T. H.; Hu, L. Q.; East Team
2015-02-01
A critical challenge facing the basic long-pulse high-confinement operation scenario (H mode) for ITER is to control a magnetohydrodynamic (MHD) instability, known as the edge localized mode (ELM), which leads to cyclical high peak heat and particle fluxes at the plasma facing components. A breakthrough is made in the Experimental Advanced Superconducting Tokamak in achieving a new steady-state H mode without the presence of ELMs for a duration exceeding hundreds of energy confinement times, by using a novel technique of continuous real-time injection of a lithium (Li) aerosol into the edge plasma. The steady-state ELM-free H mode is accompanied by a strong edge coherent MHD mode (ECM) at a frequency of 35-40 kHz with a poloidal wavelength of 10.2 cm in the ion diamagnetic drift direction, providing continuous heat and particle exhaust, thus preventing the transient heat deposition on plasma facing components and impurity accumulation in the confined plasma. It is truly remarkable that Li injection appears to promote the growth of the ECM, owing to the increase in Li concentration and hence collisionality at the edge, as predicted by GYRO simulations. This new steady-state ELM-free H -mode regime, enabled by real-time Li injection, may open a new avenue for next-step fusion development.
On the Kaolinite Floc Size at the Steady State of Flocculation in a Turbulent Flow
Zhu, Zhongfan; Wang, Hongrui; Yu, Jingshan; Dou, Jie
2016-01-01
The flocculation of cohesive fine-grained sediment plays an important role in the transport characteristics of pollutants and nutrients absorbed on the surface of sediment in estuarine and coastal waters through the complex processes of sediment transport, deposition, resuspension and consolidation. Many laboratory experiments have been carried out to investigate the influence of different flow shear conditions on the floc size at the steady state of flocculation in the shear flow. Most of these experiments reported that the floc size decreases with increasing shear stresses and used a power law to express this dependence. In this study, we performed a Couette-flow experiment to measure the size of the kaolinite floc through sampling observation and an image analysis system at the steady state of flocculation under six flow shear conditions. The results show that the negative correlation of the floc size on the flow shear occurs only at high shear conditions, whereas at low shear conditions, the floc size increases with increasing turbulent shear stresses regardless of electrolyte conditions. Increasing electrolyte conditions and the initial particle concentration could lead to a larger steady-state floc size. PMID:26901652
Amri, Amina; Pulko, Susan Helen; Wilkinson, Anthony James
2016-01-01
Breast thermography still has inherent limitations that prevent it from being fully accepted as a breast screening modality in medicine. The main challenges of breast thermography are to reduce false positive results and to increase the sensitivity of a thermogram. Further, it is still difficult to obtain information about tumour parameters such as metabolic heat, tumour depth and diameter from a thermogram. However, infrared technology and image processing have advanced significantly and recent clinical studies have shown increased sensitivity of thermography in cancer diagnosis. The aim of this paper is to study numerically the possibilities of extracting information about the tumour depth from steady state thermography and transient thermography after cold stress with no need to use any specific inversion technique. Both methods are based on the numerical solution of Pennes bioheat equation for a simple three-dimensional breast model. The effectiveness of two approaches used for depth detection from steady state thermography is assessed. The effect of breast density on the steady state thermal contrast has also been studied. The use of a cold stress test and the recording of transient contrasts during rewarming were found to be potentially suitable for tumour depth detection during the rewarming process. Sensitivity to parameters such as cold stress temperature and cooling time is investigated using the numerical model and simulation results reveal two prominent depth-related characteristic times which do not strongly depend on the temperature of the cold stress or on the cooling period.
Dougherty, T.; Maciuca, C.; McAssey, E.V. Jr.; Reddy, D.G.; Yang, B.W.
1991-07-01
This report presents results for the steady state portion of the finless single annulus test program. The objective of the experimental study was to investigate the onset of flow instability in an annular geometry similar to the MARK 22 reactor. The test program involved testing of both a finless or ribless heater and a ribbed heater. The latter program is currently underway and will be reported separately. For finless heater, testing was conducted in both a steady state and transient mode. The present report presents steady state results for a series of experiments with uniform and asymmetric heating. The demand curves obtained under uniform heating yielded OFI flow-rates which were slightly below those obtained for a circular tube geometry with the same L/D ratio; however, the single annulus had a hydraulic diameter which was approximately fifty percent larger than the circular tube. The asymmetric heating cases were selected to provide the same average power input as the uniform cases. The results for these tests indicated that the flow-rate at OFI increased with the degree of asymmetry.
A steady-state non-equilibrium molecular dynamics approach for the study of evaporation processes
NASA Astrophysics Data System (ADS)
Zhang, Jianguo; Müller-Plathe, Florian; Yahia-Ouahmed, Méziane; Leroy, Frédéric
2013-10-01
Two non-equilibrium methods (called bubble method and splitting method, respectively) have been developed and tested to study the steady state evaporation of a droplet surrounded by its vapor, where the evaporation continuously occurs at the vapor-liquid interface while the droplet size remains constant. In the bubble method, gas molecules are continuously reinserted into a free volume (represented by a bubble) located at the centre of mass of the droplet to keep the droplet size constant. In the splitting method, a molecule close to the centre of mass of the droplet is split into two: In this way, the droplet size is also maintained during the evaporation. By additional local thermostats confined to the area of insertion, the effect of frequent insertions on properties such as density and temperature can be limited to the immediate insertion area. Perturbations are not observed in other parts of the droplet. In the end, both the bubble method and the splitting method achieve steady-state droplet evaporation. Although these methods have been developed using an isolated droplet, we anticipate that they will find a wide range of applications in the study of the evaporation of isolated films and droplets or thin films on heated substrates or under confinement. They can in principle also be used to study the steady-state of other physical processes, such as the diffusion or permeation of gas molecules or ions in a pressure gradient or a concentration gradient.
The orbital PDF: general inference of the gravitational potential from steady-state tracers
NASA Astrophysics Data System (ADS)
Han, Jiaxin; Wang, Wenting; Cole, Shaun; Frenk, Carlos S.
2016-02-01
We develop two general methods to infer the gravitational potential of a system using steady-state tracers, i.e. tracers with a time-independent phase-space distribution. Combined with the phase-space continuity equation, the time independence implies a universal orbital probability density function (oPDF) dP(λ|orbit) ∝ dt, where λ is the coordinate of the particle along the orbit. The oPDF is equivalent to Jeans theorem, and is the key physical ingredient behind most dynamical modelling of steady-state tracers. In the case of a spherical potential, we develop a likelihood estimator that fits analytical potentials to the system and a non-parametric method (`phase-mark') that reconstructs the potential profile, both assuming only the oPDF. The methods involve no extra assumptions about the tracer distribution function and can be applied to tracers with any arbitrary distribution of orbits, with possible extension to non-spherical potentials. The methods are tested on Monte Carlo samples of steady-state tracers in dark matter haloes to show that they are unbiased as well as efficient. A fully documented C/PYTHON code implementing our method is freely available at a GitHub repository linked from http://icc.dur.ac.uk/data/#oPDF.
Haaland, Ben; Min, Wanli; Qian, Peter Z. G.; Amemiya, Yasuo
2011-01-01
Temperature control for a large data center is both important and expensive. On the one hand, many of the components produce a great deal of heat, and on the other hand, many of the components require temperatures below a fairly low threshold for reliable operation. A statistical framework is proposed within which the behavior of a large cooling system can be modeled and forecast under both steady state and perturbations. This framework is based upon an extension of multivariate Gaussian autoregressive hidden Markov models (HMMs). The estimated parameters of the fitted model provide useful summaries of the overall behavior of and relationships within the cooling system. Predictions under system perturbations are useful for assessing potential changes and improvements to be made to the system. Many data centers have far more cooling capacity than necessary under sensible circumstances, thus resulting in energy inefficiencies. Using this model, predictions for system behavior after a particular component of the cooling system is shut down or reduced in cooling power can be generated. Steady-state predictions are also useful for facility monitors. System traces outside control boundaries flag a change in behavior to examine. The proposed model is fit to data from a group of air conditioners within an enterprise data center from the IT industry. The fitted model is examined, and a particular unit is found to be underutilized. Predictions generated for the system under the removal of that unit appear very reasonable. Steady-state system behavior also is predicted well. PMID:22076026
A theoretical analysis of steady-state photocurrents in simple silicon diodes
NASA Technical Reports Server (NTRS)
Edmonds, L.
1995-01-01
A theoretical analysis solves for the steady-state photocurrents produced by a given photo-generation rate function with negligible recombination in simple silicon diodes, consisting of a uniformly doped quasi-neutral region (called 'substrate' below) adjacent to a p-n junction depletion region (DR). Special attention is given to conditions that produce 'funneling' (a term used by the single-eventeffects community) under steady-state conditions. Funneling occurs when carriers are generated so fast that the DR becomes flooded and partially or completely collapses. Some or nearly all of the applied voltage, plus built-in potential normally across the DR, is now across the substrate. This substrate voltage drop affects substrate currents. The steady-state problem can provide some qualitative insights into the more difficult transient problem. First, it was found that funneling can be induced from a distance, i.e., from carriers generated at locations outside of the DR. Secondly, it was found that the substrate can divide into two subregions, with one controlling substrate resistance and the other characterized by ambipolar diffusion. Finally, funneling was found to be more difficult to induce in the p(sup +)/n diode than in the n(sup +)/p diode. The carrier density exceeding the doping density in the substrate and at the DR boundary is not a sufficient condition to collapse a DR.
Arc plasma generator of atomic driver for steady-state negative ion source
Ivanov, A. A.; Belchenko, Yu. I.; Davydenko, V. I.; Ivanov, I. A.; Kolmogorov, V. V.; Listopad, A. A. Mishagin, V. V.; Shulzhenko, G. I.; Putvinsky, S. V.; Smirnov, A.
2014-02-15
The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB{sub 6} cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.
Arc plasma generator of atomic driver for steady-state negative ion source.
Ivanov, A A; Belchenko, Yu I; Davydenko, V I; Ivanov, I A; Kolmogorov, V V; Listopad, A A; Mishagin, V V; Putvinsky, S V; Shulzhenko, G I; Smirnov, A
2014-02-01
The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB6 cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.
On the Kaolinite Floc Size at the Steady State of Flocculation in a Turbulent Flow.
Zhu, Zhongfan; Wang, Hongrui; Yu, Jingshan; Dou, Jie
2016-01-01
The flocculation of cohesive fine-grained sediment plays an important role in the transport characteristics of pollutants and nutrients absorbed on the surface of sediment in estuarine and coastal waters through the complex processes of sediment transport, deposition, resuspension and consolidation. Many laboratory experiments have been carried out to investigate the influence of different flow shear conditions on the floc size at the steady state of flocculation in the shear flow. Most of these experiments reported that the floc size decreases with increasing shear stresses and used a power law to express this dependence. In this study, we performed a Couette-flow experiment to measure the size of the kaolinite floc through sampling observation and an image analysis system at the steady state of flocculation under six flow shear conditions. The results show that the negative correlation of the floc size on the flow shear occurs only at high shear conditions, whereas at low shear conditions, the floc size increases with increasing turbulent shear stresses regardless of electrolyte conditions. Increasing electrolyte conditions and the initial particle concentration could lead to a larger steady-state floc size.
Steady-State and Transient Boundary Element Methods for Coupled Heat Conduction
NASA Technical Reports Server (NTRS)
Kontinos, Dean A.
1997-01-01
Boundary element algorithms for the solution of steady-state and transient heat conduction are presented. The algorithms are designed for efficient coupling with computational fluid dynamic discretizations and feature piecewise linear elements with offset nodal points. The steady-state algorithm employs the fundamental solution approach; the integration kernels are computed analytically based on linear shape functions, linear elements, and variably offset nodal points. The analytic expressions for both singular and nonsingular integrands are presented. The transient algorithm employs the transient fundamental solution; the temporal integration is performed analytically and the nonsingular spatial integration is performed numerically using Gaussian quadrature. A series solution to the integration is derived for the instance of a singular integrand. The boundary-only character of the algorithm is maintained by integrating the influence coefficients from initial time. Numerical results are compared to analytical solutions to verify the current boundary element algorithms. The steady-state and transient algorithms are numerically shown to be second-order accurate in space and time, respectively.
Bustard, Mark A; Farley, Anne E; Bennett, Brian M; Smith, Graeme N
2003-09-01
The administration of glyceryl trinitrate (GTN; nitroglycerin) is increasing during preterm pregnancies, yet its disposition and, importantly, the extent of fetal exposure remain to be elucidated. When used as a tocolytic (pharmacological agent that stops uterine contractions), it is administered transdermally (24-48 h). Here, we quantified the maternal and fetal steady-state plasma concentrations of maternal intravenous GTN in preterm sheep and continuously monitored maternal and fetal vascular parameters to observe possible dose-dependent vascular effects. Preterm (120 days gestation) pregnant sheep (n = 6) were instrumented with maternal femoral arterial (MA) and venous (MV) and fetal femoral arterial (FA) and umbilical venous (UV) polyethylene blood-sampling catheters. During maternal GTN infusion (3.0 micro g.kg-1.min-1, 60-min duration) the steady-state GTN concentrations ([GTN]) were as follows: MA, 98.6 +/- 9.0 nM; UV, 17.4 +/- 7.6 nM; and FA, <5 nM. There were no changes in maternal and fetal mean arterial pressure and heart rate or in uterine activity. Overall, the steady-state [GTN] was established by 5 min, and the UV/MA ratio of [GTN] was 0.18. The FA [GTN] (<5 nM) indicates that the fetus cleared essentially all GTN in the UV, and the maternal and fetal heart rate and mean arterial pressure appear to be independent of maternal GTN infusion.
NASA Technical Reports Server (NTRS)
Schallhorn, Paul; Majumdar, Alok; Tiller, Bruce
2001-01-01
A general purpose, one dimensional fluid flow code is currently being interfaced with the thermal analysis program SINDA/G. The flow code, GFSSP, is capable of analyzing steady state and transient flow in a complex network. The flow code is capable of modeling several physical phenomena including compressibility effects, phase changes, body forces (such as gravity and centrifugal) and mixture thermodynamics for multiple species. The addition of GFSSP to SINDA/G provides a significant improvement in convective heat transfer modeling for SINDA/G. The interface development is conducted in multiple phases. This paper describes the first phase of the interface which allows for steady and quasisteady (unsteady solid, steady fluid) conjugate heat transfer modeling.
Generation and protection of steady-state quantum correlations due to quantum channels with memory
NASA Astrophysics Data System (ADS)
Guo, You-neng; Fang, Mao-fa; Wang, Guo-you; Zeng, Ke
2016-12-01
We have proposed a scheme of the generation and preservation of two-qubit steady-state quantum correlations through quantum channels where successive uses of the channels are correlated. Different types of noisy channels with memory, such as amplitude damping, phase damping, and depolarizing channels, have been taken into account. Some analytical or numerical results are presented. The effect of channels with memory on dynamics of quantum correlations has been discussed in detail. The results show that steady-state entanglement between two initial qubits whose initial states are prepared in a specific family states without entanglement subject to amplitude damping channel with memory can be generated. The entanglement creation is related to the memory coefficient of channel μ . The stronger the memory coefficient of channel μ is, the more the entanglement creation is, and the earlier the separable state becomes the entangled state. Besides, we compare the dynamics of entanglement with that of quantum discord when a two-qubit system is initially prepared in an entangled state. We show that entanglement dynamics suddenly disappears, while quantum discord dynamics displays only in the asymptotic limit. Furthermore, two-qubit quantum correlations can be preserved at a long time in the limit of μ → 1.
Gruchalla, Michael E.
2011-01-01
The National Instruments cRIO platform is used for the new LANSCE-R wire-scanner systems. All wire-scanner electronics are integrated into a single BiRa BiRIO 4U cRIO chassis specifically designed for the cRIO crate and all interface electronics. The BiRIO chassis, actuator and LabVIEW VIs provide a complete wire-scanner system integrated with EPICS. The new wire-scanner chassis includes an 8-slot cRIO crate with Virtex-5 LX 110 FPGA and Power-PC real-time controller, the LANL-developed cRIO 2-axis wire-sensor analog interface module (AFE), NI9222 cRIO 4-channel 16-bit digitizer, cRIO resolver demodulator, cRIO event receiver, front-panel touch panel display, motor driver, and all necessary software, interface wiring, connectors and ancillary components. This wirescanner system provides a complete, turn-key, 2-axis wire-scanner system including 2-channel low-noise sensewire interface with variable DC wire bias and wireintegrity monitor, 16-bit signal digitizers, actuator motor drive and control, actuator position sensing, limit-switch interfaces, event receiver, LabVIEW and EPICS interface, and both remote operation and full stand-alone operation using the touch panel.
Thermal noise of mechanical oscillators in steady states with a heat flux
NASA Astrophysics Data System (ADS)
Conti, Livia; Lazzaro, Claudia; Karapetyan, Gagik; Bonaldi, Michele; Pegoraro, Matteo; Thakur, Ram-Krishna; De Gregorio, Paolo; Rondoni, Lamberto
2014-09-01
We present an experimental investigation of the statistical properties of the position fluctuations of low-loss oscillators in nonequilibrium steady states. The oscillators are coupled to a heat bath, and a nonequilibrium steady state is produced by flowing a constant heat flux, setting a temperature difference across the oscillators. We investigated the distribution of the measurements of the square of the oscillator position and searched for signs of changes with respect to the equilibrium case. We found that, after normalization by the mean value, the second, third, and fourth standardized statistical moments are not modified by the underlying thermodynamic state. This differs from the behavior of the absolute, i.e., not normalized, second moment, which is strongly affected by temperature gradients and heat fluxes. We illustrate this with a numerical experiment in which we study via molecular dynamics the fluctuations of the length of a one-dimensional chain of identical particles interacting via anharmonic interparticle potentials, with the extremes thermostated at different temperatures: we use the variance of the length in correspondence to its first elastic mode of resonance to define an effective temperature which we observe to depart from the thermodynamic one in the nonequilibrium states. We investigate the effect of changing the interparticle potential and show that the qualitative behavior of the nonequilibrium excess is unchanged. Our numerical results are consistent with the chain length being Gaussian distributed in the nonequilibrium states. Our experimental investigation reveals that the position variance is the only, and crucially easily accessible, observable for distinguishing equilibrium from nonequilibrium steady states. The consequences of this fact for the design of interferometric gravitational wave detectors are discussed.
On the Stress-Temperature Scaling for Steady-State Flow in Metallic Glasses
Guan, Pengfei; Chen, Mingwei; Egami, T.
2010-01-01
Through computer simulation of steady-state flow in a Zr50Cu40Al10 metallic glass using a set of realistic potentials we found a simple scaling relationship between temperature and stress as they affect viscosity. The scaling relationship provides new insights for the microscopic mechanism of shear flow in the glassy state, in terms of the elastic energy of the applied stress modifying the local energy landscape. The results suggest that the plastic flow and mechanical failure in metallic glasses are consequences of stress-induced glass transition.
Stress-Temperature Scaling for Steady-State Flow in Metallic Glasses
NASA Astrophysics Data System (ADS)
Guan, Pengfei; Chen, Mingwei; Egami, Takeshi
2010-05-01
Through computer simulation of steady-state flow in a Zr50Cu40Al10 metallic glass using a set of realistic potentials we find a simple scaling relationship between temperature and stress as they affect viscosity. The scaling relationship provides new insight into the microscopic mechanism of shear flow in the glassy state, in terms of the elastic energy of the applied stress modifying the local energy landscape. The results suggest that the plastic flow and mechanical failure in metallic glasses are consequences of stress-induced glass transition.
NASA Astrophysics Data System (ADS)
Daga, Bijoy; Mondal, Souvik; Chandra, Anjan Kumar; Banerjee, Tirthankar; Basu, Abhik
2017-01-01
We study the totally asymmetric exclusion process (TASEP) on a nonuniform one-dimensional ring consisting of two segments having unequal hopping rates, or defects. We allow weak particle nonconservation via Langmuir kinetics (LK), which are parametrized by generic unequal attachment and detachment rates. For an extended defect, in the thermodynamic limit the system generically displays inhomogeneous density profiles in the steady state—the faster segment is either in a phase with spatially varying density having no density discontinuity, or a phase with a discontinuous density changes. Nonequilibrium phase transitions between the above phases are controlled by the inhomogeneity and LK. The slower segment displays only macroscopically uniform bulk density profiles in the steady states, reminiscent of the maximal current phase of TASEP but with a bulk density generally different from half. With a point defect, there are spatially uniform low- and high-density phases as well, in addition to the inhomogeneous density profiles observed for an extended defect. In all the cases, it is argued that the mean particle density in the steady state is controlled only by the ratio of the LK attachment and detachment rates.
Measurement and Characterization of Helicopter Noise in Steady-State and Maneuvering Flight
NASA Technical Reports Server (NTRS)
Schmitz, Fredric H.; Greenwood, Eric; Sickenberger, Richard D.; Gopalan, Gaurav; Sim, Ben Well-C; Conner, David; Moralez, Ernesto; Decker, William A.
2007-01-01
A special acoustic flight test program was performed on the Bell 206B helicopter outfitted with an in-flight microphone boom/array attached to the helicopter while simultaneous acoustic measurements were made using a linear ground array of microphones arranged to be perpendicular to the flight path. Air and ground noise measurements were made in steady-state longitudinal and steady turning flight, and during selected dynamic maneuvers. Special instrumentation, including direct measurement of the helicopter s longitudinal tip-path-plane (TPP) angle, Differential Global Positioning System (DGPS) and Inertial Navigation Unit (INU) measurements, and a pursuit guidance display were used to measure important noise controlling parameters and to make the task of flying precise operating conditions and flight track easier for the pilot. Special care was also made to test only in very low winds. The resulting acoustic data is of relatively high quality and shows the value of carefully monitoring and controlling the helicopter s performance state. This paper has shown experimentally, that microphones close to the helicopter can be used to estimate the specific noise sources that radiate to the far field, if the microphones are positioned correctly relative to the noise source. Directivity patterns for steady, turning flight were also developed, for the first time, and connected to the turning performance of the helicopter. Some of the acoustic benefits of combining normally separated flight segments (i.e. an accelerated segment and a descending segment) were also demonstrated.
Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux
Liemburg-Apers, Dania C.; Schirris, Tom J.J.; Russel, Frans G.M.; Willems, Peter H.G.M.; Koopman, Werner J.H.
2015-01-01
ATP can be produced in the cytosol by glycolytic conversion of glucose (GLC) into pyruvate. The latter can be metabolized into lactate, which is released by the cell, or taken up by mitochondria to fuel ATP production by the tricarboxylic acid cycle and oxidative phosphorylation (OXPHOS) system. Altering the balance between glycolytic and mitochondrial ATP generation is crucial for cell survival during mitoenergetic dysfunction, which is observed in a large variety of human disorders including cancer. To gain insight into the kinetic properties of this adaptive mechanism we determined here how acute (30 min) inhibition of OXPHOS affected cytosolic GLC homeostasis. GLC dynamics were analyzed in single living C2C12 myoblasts expressing the fluorescent biosensor FLII12Pglu-700μδ6 (FLII). Following in situ FLII calibration, the kinetic properties of GLC uptake (V1) and GLC consumption (V2) were determined independently and used to construct a minimal mathematical model of cytosolic GLC dynamics. After validating the model, it was applied to quantitatively predict V1 and V2 at steady-state (i.e., when V1 = V2 = Vsteady-state) in the absence and presence of OXPHOS inhibitors. Integrating model predictions with experimental data on lactate production, cell volume, and O2 consumption revealed that glycolysis and mitochondria equally contribute to cellular ATP production in control myoblasts. Inhibition of OXPHOS induced a twofold increase in Vsteady-state and glycolytic ATP production flux. Both in the absence and presence of OXPHOS inhibitors, GLC was consumed at near maximal rates, meaning that GLC consumption is rate-limiting under steady-state conditions. Taken together, we demonstrate here that OXPHOS inhibition increases steady-state GLC uptake and consumption in C2C12 myoblasts. This activation fully compensates for the reduction in mitochondrial ATP production, thereby maintaining the balance between cellular ATP supply and demand. PMID:26445438
Los Alamos Neutron Science Center (LANSCE) Nuclear Science Facilities
Nelson, Ronald Owen; Wender, Steve
2015-06-19
The Los Alamos Neutron Science Center (LANSCE) facilities for Nuclear Science consist of a high-energy "white" neutron source (Target 4) with 6 flight paths, three low-energy nuclear science flight paths at the Lujan Center, and a proton reaction area. The neutron beams produced at the Target 4 complement those produced at the Lujan Center because they are of much higher energy and have shorter pulse widths. The neutron sources are driven by the 800-MeV proton beam of the LANSCE linear accelerator. With these facilities, LANSCE is able to deliver neutrons with energies ranging from a milli-electron volt to several hundreds of MeV, as well as proton beams with a wide range of energy, time and intensity characteristics. The facilities, instruments and research programs are described briefly.
A mathematical model of liver metabolism: from steady state to dynamic
NASA Astrophysics Data System (ADS)
Calvetti, D.; Kuceyeski, A.; Somersalo, E.
2008-07-01
The increase in Type 2 diabetes and other metabolic disorders has led to an intense focus on the areas of research related to metabolism. Because the liver is essential in regulating metabolite concentrations that maintain life, it is especially important to have good knowledge of the functions within this organ. In silico mathematical models that can adequately describe metabolite concentrations, flux and transport rates in the liver in vivo can be a useful predictive tool. Fully dynamic models, which contain expressions for Michaelis-Menten reaction kinetics can be utilized to investigate different metabolic states, for example exercise, fed or starved state. In this paper we describe a two compartment (blood and tissue) spatially lumped liver metabolism model. First, we use Bayesian Flux Balance Analysis (BFBA) to estimate the values of flux and transport rates at steady state, which agree closely with values from the literature. These values are then used to find a set of Michaelis-Menten parameters and initial concentrations which identify a dynamic model that can be used for exploring different metabolic states. In particular, we investigate the effect of doubling the concentration of lactate entering the system via the hepatic artery and portal vein. This change in lactate concentration forces the system to a new steady state, where glucose production is increased.
Dubbert, Maren; Cuntz, Matthias; Piayda, Arndt; Werner, Christiane
2014-09-01
The oxygen isotope signature of water is a powerful tracer of water movement from plants to the global scale. However, little is known about the short-term variability of oxygen isotopes leaving the ecosystem via transpiration, as high-frequency measurements are lacking. A laser spectrometer was coupled to a gas-exchange chamber directly estimating branch-level fluxes in order to evaluate the short-term variability of the isotopic composition of transpiration (δE ) and to investigate the role of isotopic non-steady-state transpiration under natural conditions in cork-oak trees (Quercus suber) during distinct Mediterranean seasons. The measured δ(18) O of transpiration (δE ) deviated from isotopic steady state throughout most of the day even when leaf water at the evaporating sites was near isotopic steady state. High agreement was found between estimated and modeled δE values assuming non-steady-state enrichment of leaf water. Isoforcing, that is, the influence of the transpirational δ(18) O flux on atmospheric values, deviated from steady-state calculations but daily means were similar between steady state and non-steady state. However, strong daytime isoforcing on the atmosphere implies that short-term variations in δE are likely to have consequences for large-scale applications, for example, partitioning of ecosystem fluxes or satellite-based applications.
Hughes, Michael F.; Edwards, Brenda C.; Herbin-Davis, Karen M.; Saunders, Jesse; Styblo, Miroslav; Thomas, David J.
2010-12-15
Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-, and tri-methylated metabolites of inorganic arsenic. Distribution and retention of arsenic were compared in adult female As3mt knockout mice and wild-type C57BL/6 mice using a regimen in which mice received daily oral doses of 0.5 mg of arsenic as arsenate per kilogram of body weight. Regardless of genotype, arsenic body burdens attained steady state after 10 daily doses. At steady state, arsenic body burdens in As3mt knockout mice were 16 to 20 times greater than in wild-type mice. During the post dosing clearance period, arsenic body burdens declined in As3mt knockout mice to {approx} 35% and in wild-type mice to {approx} 10% of steady-state levels. Urinary concentration of arsenic was significantly lower in As3mt knockout mice than in wild-type mice. At steady state, As3mt knockout mice had significantly higher fractions of the body burden of arsenic in liver, kidney, and urinary bladder than did wild-type mice. These organs and lung had significantly higher arsenic concentrations than did corresponding organs from wild-type mice. Inorganic arsenic was the predominant species in tissues of As3mt knockout mice; tissues from wild-type mice contained mixtures of inorganic arsenic and its methylated metabolites. Diminished capacity for arsenic methylation in As3mt knockout mice prolongs retention of inorganic arsenic in tissues and affects whole body clearance of arsenic. Altered retention and tissue tropism of arsenic in As3mt knockout mice could affect the toxic or carcinogenic effects associated with exposure to this metalloid or its methylated metabolites.
NASA Astrophysics Data System (ADS)
Tsakiroglou, C. D.; Avraam, D. G.; Payatakes, A. C.
2007-09-01
The water krw and oil kro relative permeability curves of a glass-etched planar pore network are estimated with history matching from transient displacement experiments performed at varying values of the capillary number, Ca, for two fluid systems: one of intermediate and one of strong wettability. The transient k,k are compared to corresponding ones measured with the steady-state method on the same porous medium [Avraam DG, Payatakes AC. Flow regimes and relative permeabilities during steady-state two-phase flow in porous media. J Fluid Mech 1995;293:207-36; Avraam DG, Payatakes AC. Generalized relative permeability coefficients during steady-state two-phase flow in porous media and correlation with the flow mechanisms. Transport Porous Med 1995;20:135-68; Avraam DG, Payatakes AC. Flow mechanisms, relative permeabilities, and coupling effects in steady-state two-phase flow through porous media. The case of strong wettability. Ind Eng Chem Res 1999;38:778-86.], and potential differences from them are interpreted in the light of the differences between the transient growth pattern, and the steady-state two-phase flow regime. For intermediate wettability, the transient kro and krw exceed the corresponding steady-state functions at low Ca values and have the tendency to become smaller than the steady-state ones at high Ca values. For strong wettability, the transient kro and krw are increasing functions of Ca, the transient kro is higher than the steady-state one, whereas the transient krw decreases substantially and becomes lower than the steady-state one at low Ca values. The dynamic capillary pressure estimated from transient experiments is a decreasing function of Ca in agreement with previous theoretical and experimental studies.
Overview of the Neutron experimental facilities at LANSCE
Mocko, Michal
2016-06-30
This presentation gives an overview of the neutron experimental facilities at LANSCE. The layout is mentioned in detail, with a map of the south-side experimental facilities, information on Target-4 and the Lujan Center. Then it goes into detail about neutron sources, specifically continuous versus pulsed. Target 4 is then discussed. In conclusion, we have introduced the south-side experimental facilities in operation at LANSCE. 1L target and Target 4 provide complementary neutron energy spectra. Two spallation neutron sources taken together cover more than 11 orders of magnitude in neutron energy.
NASA Astrophysics Data System (ADS)
De Silvestri, S.; Laporta, P.
1984-01-01
Time-resolved and steady-state fluorescence studies of proflavine in aqueous solution are presented. The observation of a monoexponential fluorescence decay with a time constant decreasing with increasing pH and the presence of an anomalous red-shift in the fluorescence spectrum as a function of pH indicate the existence of a complex proton-transfer mechanism in the excited state. A reaction scheme is proposed and the corresponding proton-transfer rates are evaluated. An excited-state pK value of 12.85 is obtained for the equilibrium between the cationic form of proflavine and the same form dissociated at an amino group.
Steady-State Characterization of Bacteriorhodopsin-D85N Photocycle
NASA Technical Reports Server (NTRS)
Timucin, Dogan A.; Downie, John D.; Norvig, Peter (Technical Monitor)
1999-01-01
An operational characterization of the photocycle of the genetic mutant D85N of bacteriorhodopsin, BR-D85N, is presented. Steady-state bleach spectra and pump-probe absorbance data are obtained with thick hydrated films containing BR-D85N embedded in a gelatin host. Simple two- and three-state models are used to analyze the photocycle dynamics and extract relevant information such as pure-state absorption spectra, photochemical-transition quantum efficiencies, and thermal lifetimes of dominant states appearing in the photocycle, the knowledge of which should aid in the analysis of optical recording and retrieval of data in films incorporating this photochromic material. The remarkable characteristics of this material and their implications from the viewpoint of optical data storage and processing are discussed.
Steady state estimation of soil organic carbon using satellite-derived canopy leaf area index
Fang, Yilin; Liu, Chongxuan; Huang, Maoyi; ...
2014-12-02
Soil organic carbon (SOC) plays a key role in the global carbon cycle that is important for decadal-to-century climate prediction. Estimation of soil organic carbon stock using model-based methods typically requires spin-up (time marching transient simulation) of the carbon-nitrogen (CN) models by performing hundreds to thousands years long simulations until the carbon-nitrogen pools reach dynamic steady-state. This has become a bottleneck for global modeling and analysis, especially when testing new physical and/or chemical mechanisms and evaluating parameter sensitivity. Here we report a new numerical approach to estimate global soil carbon stock that can avoid the long term spin-up of themore » CN model. The approach uses canopy leaf area index (LAI) from satellite data and takes advantage of a reaction-based biogeochemical module NGBGC (Next Generation BioGeoChemical Module) that was recently developed and incorporated in version 4 of the Community Land Model (CLM4). Although NGBGC uses the same CN mechanisms as used in CLM4CN, it can be easily configured to run prognostic or steady state simulations. In this approach, monthly LAI from the multi-year Moderate Resolution Imaging Spectroradiometer (MODIS) data was used to calculate potential annual average gross primary production (GPP) and leaf carbon for the period of the atmospheric forcing. The calculated potential annual average GPP and leaf C are then used by NGBGC to calculate the steady-state distributions of carbon and nitrogen in different vegetation and soil pools by solving the steady-state reaction-network in NGBGC using the Newton-Raphson method. The new approach was applied at point and global scales and compared with SOC derived from long spin-up by running NGBGC in prognostic mode, and SOC from the empirical data of the Harmonized World Soil Database (HWSD). The steady-state solution is comparable to the spin-up value when the MODIS LAI is close to the LAI from the spin-up solution, and largely
Steady state estimation of soil organic carbon using satellite-derived canopy leaf area index
Fang, Yilin; Liu, Chongxuan; Huang, Maoyi; Li, Hongyi; Leung, Lai-Yung R.
2014-12-02
Soil organic carbon (SOC) plays a key role in the global carbon cycle that is important for decadal-to-century climate prediction. Estimation of soil organic carbon stock using model-based methods typically requires spin-up (time marching transient simulation) of the carbon-nitrogen (CN) models by performing hundreds to thousands years long simulations until the carbon-nitrogen pools reach dynamic steady-state. This has become a bottleneck for global modeling and analysis, especially when testing new physical and/or chemical mechanisms and evaluating parameter sensitivity. Here we report a new numerical approach to estimate global soil carbon stock that can avoid the long term spin-up of the CN model. The approach uses canopy leaf area index (LAI) from satellite data and takes advantage of a reaction-based biogeochemical module NGBGC (Next Generation BioGeoChemical Module) that was recently developed and incorporated in version 4 of the Community Land Model (CLM4). Although NGBGC uses the same CN mechanisms as used in CLM4CN, it can be easily configured to run prognostic or steady state simulations. In this approach, monthly LAI from the multi-year Moderate Resolution Imaging Spectroradiometer (MODIS) data was used to calculate potential annual average gross primary production (GPP) and leaf carbon for the period of the atmospheric forcing. The calculated potential annual average GPP and leaf C are then used by NGBGC to calculate the steady-state distributions of carbon and nitrogen in different vegetation and soil pools by solving the steady-state reaction-network in NGBGC using the Newton-Raphson method. The new approach was applied at point and global scales and compared with SOC derived from long spin-up by running NGBGC in prognostic mode, and SOC from the empirical data of the Harmonized World Soil Database (HWSD). The steady-state solution is comparable to the spin-up value when the MODIS LAI is close to the LAI from the spin-up solution, and largely
Steady-state and femtosecond photoinduced processes of blepharismins bound to alpha-crystallin.
Youssef, T; Brazard, J; Ley, C; Lacombat, F; Plaza, P; Martin, M M; Sgarbossa, A; Checcucci, G; Lenci, F
2008-07-01
The interaction of blepharismin (BP) and oxyblepharismin (OxyBP) with bovine alpha-crystallin (BAC) has been studied both by steady-state and femtosecond spectroscopy, with the aim of assessing the possible phototoxicity of these compounds toward the eye tissues. We showed that these pigments form with BAC potentially harmful ground-state complexes, the dissociation constants of which have been estimated to be 6 +/- 2 micromol L(-1) for OxyBP and 9 +/- 4 micromol L(-1) for BP. Irradiation with steady-state visible light of solutions of blepharismins in the presence of BAC proved to induce a quenching of both the pigment and the intrinsic protein fluorescences. These effects were tentatively rationalized in terms of structural changes of alpha-crystallin. On the other hand, femtosecond transient absorption spectroscopy was used to check the occurrence of any type I photoactivity of oxyblepharismin bound to alpha-crystallin. The existence of a particular type of fast photoinduced reaction, not observed in former studies with human serum albumin but present in the natural oxyblepharismin-binding protein, could here be evidenced but no specific reaction was observed during the first few nanoseconds after excitation. Partial denaturation of alpha-crystallin was however found to alter the excited-state behaviour of its complex with oxyblepharismin, making it partly resemble that of free oxyblepharismin in solution.
Yamori, Wataru; Masumoto, Chisato; Fukayama, Hiroshi; Makino, Amane
2012-09-01
The role of Rubisco activase in steady-state and non-steady-state photosynthesis was analyzed in wild-type (Oryza sativa) and transgenic rice that expressed different amounts of Rubisco activase. Below 25°C, the Rubisco activation state and steady-state photosynthesis were only affected when Rubisco activase was reduced by more than 70%. However, at 40°C, smaller reductions in Rubisco activase content were linked to a reduced Rubisco activation state and steady-state photosynthesis. As a result, overexpression of maize Rubisco activase in rice did not lead to an increase of the Rubisco activation state, nor to an increase in photosynthetic rate below 25°C, but had a small stimulatory effect at 40°C. On the other hand, the rate at which photosynthesis approached the steady state following an increase in light intensity was rapid in Rubisco activase-overexpressing plants, intermediate in the wild-type, and slowest in antisense plants at any leaf temperature. In Rubisco activase-overexpressing plants, Rubisco activation state at low light was maintained at higher levels than in the wild-type. Thus, rapid regulation by Rubisco activase following an increase in light intensity and/or maintenance of a high Rubisco activation state at low light would result in a rapid increase in Rubisco activation state and photosynthetic rate following an increase in light intensity. It is concluded that Rubisco activase plays an important role in the regulation of non-steady-state photosynthesis at any leaf temperature and, to a lesser extent, of steady-state photosynthesis at high temperature.
NASA Technical Reports Server (NTRS)
Pogorzelski, Ronald J.
2004-01-01
When electronic oscillators are coupled to nearest neighbors to form an array on a hexagonal lattice, the planar phase distributions desired for excitation of a phased array antenna are not steady state solutions of the governing non-linear equations describing the system. Thus the steady state phase distribution deviates from planar. It is shown to be possible to obtain an exact solution for the steady state phase distribution and thus determine the deviation from the desired planar distribution as a function of beam steering angle.
Lyra, Wladimir; Lin, Min-Kai E-mail: mklin924@cita.utoronto.ca
2013-09-20
The Atacama Large Millimeter Array has returned images of transitional disks in which large asymmetries are seen in the distribution of millimeter sized dust in the outer disk. The explanation in vogue borrows from the vortex literature and suggests that these asymmetries are the result of dust trapping in giant vortices, excited via Rossby wave instabilities at planetary gap edges. Due to the drag force, dust trapped in vortices will accumulate in the center and diffusion is needed to maintain a steady state over the lifetime of the disk. While previous work derived semi-analytical models of the process, in this paper we provide analytical steady-steady solutions. Exact solutions exist for certain vortex models. The solution is determined by the vortex rotation profile, the gas scale height, the vortex aspect ratio, and the ratio of dust diffusion to gas-dust friction. In principle, all of these quantities can be derived from observations, which would validate the model and also provide constrains on the strength of the turbulence inside the vortex core. Based on our solution, we derive quantities such as the gas-dust contrast, the trapped dust mass, and the dust contrast at the same orbital location. We apply our model to the recently imaged Oph IRS 48 system, finding values within the range of the observational uncertainties.
Minimal gain marching schemes: searching for unstable steady-states with unsteady solvers
NASA Astrophysics Data System (ADS)
de S. Teixeira, Renan; S. de B. Alves, Leonardo
2017-03-01
Reference solutions are important in several applications. They are used as base states in linear stability analyses as well as initial conditions and reference states for sponge zones in numerical simulations, just to name a few examples. Their accuracy is also paramount in both fields, leading to more reliable analyses and efficient simulations, respectively. Hence, steady-states usually make the best reference solutions. Unfortunately, standard marching schemes utilized for accurate unsteady simulations almost never reach steady-states of unstable flows. Steady governing equations could be solved instead, by employing Newton-type methods often coupled with continuation techniques. However, such iterative approaches do require large computational resources and very good initial guesses to converge. These difficulties motivated the development of a technique known as selective frequency damping (SFD) (Åkervik et al. in Phys Fluids 18(6):068102, 2006). It adds a source term to the unsteady governing equations that filters out the unstable frequencies, allowing a steady-state to be reached. This approach does not require a good initial condition and works well for self-excited flows, where a single nonzero excitation frequency is selected by either absolute or global instability mechanisms. On the other hand, it seems unable to damp stationary disturbances. Furthermore, flows with a broad unstable frequency spectrum might require the use of multiple filters, which delays convergence significantly. Both scenarios appear in convectively, absolutely or globally unstable flows. An alternative approach is proposed in the present paper. It modifies the coefficients of a marching scheme in such a way that makes the absolute value of its linear gain smaller than one within the required unstable frequency spectra, allowing the respective disturbance amplitudes to decay given enough time. These ideas are applied here to implicit multi-step schemes. A few chosen test cases
High-power and steady-state operation of ICRF heating in the large helical device
Mutoh, T. Seki, T.; Saito, K.; Kasahara, H.; Seki, R.; Kamio, S.; Kumazawa, R.; Kubo, S.; Shimozuma, T.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Ii, T.; Makino, R.; Nagaoka, K.; Nomura, G.; Shinya, T.
2015-12-10
Recent progress in an ion cyclotron range of frequencies (ICRF) heating system and experiment results in a Large Helical Device (LHD) are reported. Three kinds of ICRF antenna pairs were installed in the LHD, and the operation power regimes were extended up to 4.5 MW; also, the steady-state operation was extended for more than 45 min in LHD at a MW power level. We studied ICRF heating physics in heliotron configuration using a Hand Shake type (HAS) antenna, Field Aligned Impedance Transforming (FAIT) antenna, and Poloidal Array (PA) antenna, and established the optimum minority-ion heating scenario in an LHD. The FAIT antenna having a novel impedance transformer inside the vacuum chamber could reduce the VSWR and successfully injected a higher power to plasma. We tested the PA antennas completely removing the Faraday-shield pipes to avoid breakdown and to increase the plasma coupling. The heating performance was almost the same as other antennas; however, the heating efficiency was degraded when the gap between the antenna and plasma surface was large. Using these three kinds of antennas, ICRF heating could contribute to raising the plasma beta with the second- and third-harmonic cyclotron heating mode, and also to raising the ion temperature as discharge cleaning tools. In 2014, steady-state operation plasma with a line-averaged electron density of 1.2 × 10{sup 19} m{sup −3}, ion and electron temperature of 2 keV, and plasma sustainment time of 48 min was achieved with ICH and ECH heating power of 1.2 MW for majority helium with minority hydrogen. In 2015, the higher-power steady-state operation with a heating power of up to 3 MW was tested with higher density of 3 × 10{sup 19} m{sup −3}.
Pharmacokinetics of phase I nevirapine metabolites following a single dose and at steady state.
Fan-Havard, Patty; Liu, Zhongfa; Chou, Monidarin; Ling, Yonghua; Barrail-Tran, Aurélie; Haas, David W; Taburet, Anne-Marie
2013-05-01
Nevirapine is one of the most extensively prescribed antiretrovirals worldwide. The present analyses used data and specimens from two prior studies to characterize and compare plasma nevirapine phase I metabolite profiles following a single 200-mg oral dose of nevirapine in 10 HIV-negative African Americans and a steady-state 200-mg twice-daily dose in 10 HIV-infected Cambodians. Nevirapine was assayed by high-performance liquid chromatography (HPLC). The 2-, 3-, 8- and 12-hydroxy and 4-carboxy metabolites of nevirapine were assayed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). Pharmacokinetic parameters were calculated by noncompartmental analysis. The metabolic index for each metabolite was defined as the ratio of the metabolite area under the concentration-time curve (AUC) to the nevirapine AUC. Every metabolite concentration was much less than the corresponding nevirapine concentration. The predominant metabolite after single dose and at steady state was 12-hydroxynevirapine. From single dose to steady state, the metabolic index increased for 3-hydroxynevirapine (P < 0.01) but decreased for 2-hydroxynevirapine (P < 0.001). The 3-hydroxynevirapine metabolic index was correlated with nevirapine apparent clearance (P < 0.001). These findings are consistent with induction of CYP2B6 (3-hydroxy metabolite) and a possible inhibition of CYP3A (2-hydroxy metabolite), although these are preliminary data. There were no such changes in metabolic indexes for 12-hydroxynevirapine or 4-carboxynevirapine. Two subjects with the CYP2B6 *6*6 genetic polymorphism had metabolic indexes in the same range as other subjects. These results suggest that nevirapine metabolite profiles change over time under the influence of enzyme induction, enzyme inhibition, and host genetics. Further work is warranted to elucidate nevirapine biotransformation pathways and implications for drug efficacy and toxicity.
Wolfaardt, G. M.; Lawrence, J. R.; Hendry, M. J.; Robarts, R. D.; Caldwell, D. E.
1993-01-01
A diffusion gradient plate was constructed and evaluated for its potential use in the isolation of degradative microbial consortia from natural habitats. In this model, a steady-state concentration gradient of diclofop methyl, established by diffusion through an agarose gel, provided the carbon for microbial growth. Colonization of the gel surface was observed with epifluorescence and scanning confocal laser microscopy to determine microbial responses to the diclofop gradient. A detectable gradient developed over a narrow band (<10 mm). Consequently, quantitative analyses of the microbial response to the gradient were difficult to obtain. A two-dimensional, finite-element numerical transport model for advective-diffusive transport was used to simulate concentration and flux profiles in the physical model. The simulated profiles were correlated with the measured concentration gradient (R2 = 0.89) and the cell numbers on the gel surface (R2 = 0.85). The numerical model was subsequently used to redesign the physical model. The detectable concentration gradient in the modified physical model extended over the length of the gel (38 mm). The simulated profile again showed a good correlation with the measured profile (R2 = 0.96) and the microbial responses to the concentration gradient (R2 = 0.99). It was concluded that these gradients provide the steady-state environments needed to sustain steady-state consortia. They also provide a physical pathway for the development of degradative biofilms from low to high concentrations of toxicants and simulate conditions under which low concentrations of toxicant are supplied at a constant flux over long periods of time, such as the conditions that could occur in natural environments. Images PMID:16349007
Modeling of the blood rheology in steady-state shear flows
Apostolidis, Alex J.; Beris, Antony N.
2014-05-15
We undertake here a systematic study of the rheology of blood in steady-state shear flows. As blood is a complex fluid, the first question that we try to answer is whether, even in steady-state shear flows, we can model it as a rheologically simple fluid, i.e., we can describe its behavior through a constitutive model that involves only local kinematic quantities. Having answered that question positively, we then probe as to which non-Newtonian model best fits available shear stress vs shear-rate literature data. We show that under physiological conditions blood is typically viscoplastic, i.e., it exhibits a yield stress that acts as a minimum threshold for flow. We further show that the Casson model emerges naturally as the best approximation, at least for low and moderate shear-rates. We then develop systematically a parametric dependence of the rheological parameters entering the Casson model on key physiological quantities, such as the red blood cell volume fraction (hematocrit). For the yield stress, we base our description on its critical, percolation-originated nature. Thus, we first determine onset conditions, i.e., the critical threshold value that the hematocrit has to have in order for yield stress to appear. It is shown that this is a function of the concentration of a key red blood cell binding protein, fibrinogen. Then, we establish a parametric dependence as a function of the fibrinogen and the square of the difference of the hematocrit from its critical onset value. Similarly, we provide an expression for the Casson viscosity, in terms of the hematocrit and the temperature. A successful validation of the proposed formula is performed against additional experimental literature data. The proposed expression is anticipated to be useful not only for steady-state blood flow modeling but also as providing the starting point for transient shear, or more general flow modeling.
Steady-state responses of a belt-drive dynamical system under dual excitations
NASA Astrophysics Data System (ADS)
Ding, Hu
2016-02-01
The stable steady-state periodic responses of a belt-drive system with a one-way clutch are studied. For the first time, the dynamical system is investigated under dual excitations. The system is simultaneously excited by the firing pulsations of the engine and the harmonic motion of the foundation. Nonlinear discrete-continuous equations are derived for coupling the transverse vibration of the belt spans and the rotations of the driving and driven pulleys and the accessory pulley. The nonlinear dynamics is studied under equal and multiple relations between the frequency of the firing pulsations and the frequency of the foundation motion. Furthermore, translating belt spans are modeled as axially moving strings. A set of nonlinear piecewise ordinary differential equations is achieved by using the Galerkin truncation. Under various relations between the excitation frequencies, the time histories of the dynamical system are numerically simulated based on the time discretization method. Furthermore, the stable steady-state periodic response curves are calculated based on the frequency sweep. Moreover, the convergence of the Galerkin truncation is examined. Numerical results demonstrate that the one-way clutch reduces the resonance amplitude of the rotations of the driven pulley and the accessory pulley. On the other hand, numerical examples prove that the resonance areas of the belt spans are decreased by eliminating the torque-transmitting in the opposite direction. With the increasing amplitude of the foundation excitation, the damping effect of the one-way clutch will be reduced. Furthermore, as the amplitude of the firing pulsations of the engine increases, the jumping phenomena in steady-state response curves of the belt-drive system with or without a one-way clutch both occur.
FtsZ Filament Dynamics at Steady State: Subunit Exchange with and without Nucleotide Hydrolysis†
Chen, Yaodong; Erickson, Harold P.
2009-01-01
We have measured three aspects of FtsZ filament dynamics at steady state: rates of GTP hydrolysis, subunit exchange between protofilaments, and disassembly induced by dilution or excess GDP. All three reactions were slowed with an increase in the potassium concentration from 100 to 500 mM, via replacement of potassium with rubidium, or with an increase in the magnesium concentration from 5 to 20 mM. Electron microscopy showed that the polymers assembled under the conditions of fastest assembly were predominantly short, one-stranded protofilaments, whereas under conditions of slower dynamics, the protofilaments tended to associate into long, thin bundles. We suggest that exchange of subunits between protofilaments at steady state involves two separate mechanisms: (1) fragmentation or dissociation of subunits from protofilament ends following GTP hydrolysis and (2) reversible association and dissociation of subunits from protofilament ends independent of hydrolysis. Exchange of nucleotides on these recycling subunits could give the appearance of exchange directly into the polymer. Several of our observations suggest that exchange of nucleotide can take place on these recycling subunits, but not directly into the FtsZ polymer. Annealing of protofilaments was demonstrated for the L68W mutant in EDTA buffer but not in Mg buffer, where rapid cycling of subunits may obscure the effect of annealing. We also reinvestigated the nucleotide composition of FtsZ polymers at steady state. We found that the GDP:GTP ratio was 50:50 for concentrations of GTP > 100 μM, significantly higher than the 20:80 ratio previously reported at 20 μM GTP. PMID:19527070
Guan, Wei-Jie; Gao, Yong-Hua; Xu, Gang; Lin, Zhi-Ya; Tang, Yan; Li, Hui-Min; Li, Zhi-Min; Zheng, Jin-Ping
2015-01-01
Background Current status of Pseudomonas aeruginosa (PA) infection in clinically stable bronchiectasis in mainland China remains unclear. Objective To compare the inflammation and lung function impairment in bronchiectasis patients isolated or infected with PA, potentially pathogenic microorganisms (PPMs) and commensals, and to identify factors associated with PA isolation and infection. Methods Patients with steady-state bronchiectasis and healthy subjects were recruited. Peripheral blood and sputum were sampled to determine inflammatory markers and bacterial loads in steady-state bronchiectasis and health. Spirometry and diffusing capacity were also measured. Results We enrolled 144 bronchiectasis patients and 23 healthy subjects. PA isolation and infection accounted for 44 and 39 patients, who demonstrated significant inflammatory responses and markedly impaired spirometry, but not diffusing capacity, compared with healthy subjects and patients isolated with other PPMs and commensals (all P<0.05). Except for heightened sputum inflammatory responses, there were no notable differences in serum inflammation and lung function as with the increased density of PA. Female gender [odds ratio (OR): 3.10 for PA isolation; OR: 3.74 for PA infection], 4 or more exacerbations within 2 years (OR: 3.74 for PA isolation, OR: 2.95 for PA infection) and cystic bronchiectasis (OR: 3.63 for PA isolation, OR: 4.47 for PA infection) were the factors consistently associated with PA isolation and infection. Conclusions PA elicits intense inflammation and lung function impairment in steady-state bronchiectasis. The density of PA does not correlate with most clinical indices. PA infection is associated with females, frequent exacerbations and cystic bronchiectasis. PMID:25973228
Steady-state diffusion of water through soft-contact-lens materials.
Fornasiero, Francesco; Krull, Florian; Prausnitz, John M; Radke, Clayton J
2005-10-01
Water transport through soft contact lenses (SCL) is important for acceptable performance on the human eye. Chemical-potential gradient-driven diffusion rates of water through SCL materials are measured with an evaporation-cell technique. Water is evaporated from the bottom surface of a lens membrane by impinging air at controlled flow rate and humidity. The resulting weight loss of a water reservoir covering the top surface of the contact-lens material is recorded as a function of time. New results are reported for a conventional hydrogel material (SofLens One Day, hilafilcon A, water content at saturation w10 = 70 weight %) and a silicone hydrogel material (PureVision, balafilcon A, w10 = 36%), with and without surface oxygen plasma treatment. Also, previously reported data for a conventional 2-hydroxyethyl methacrylate (HEMA)-SCL (w10 = 38%) hydrogel are reexamined and compared with those for SofLens One Day and PureVision hydrogels. Measured steady-state water fluxes are largest for SofLens One Day, followed by PureVision and HEMA. In some cases, the measured steady-state water fluxes increase with rising relative air humidity. This increase, due to an apparent mass-transfer resistance at the surface (trapping skinning), is associated with formation of a glassy skin at the air/membrane interface when the relative humidity is below 55-75%. Steady-state water fluxes are interpreted through an extended Maxwell-Stefan diffusion model for a mixture of species starkly different in size. Thermodynamic nonideality is considered through Flory-Rehner polymer-solution theory. Shrinking/swelling is self-consistently modeled by conservation of the total polymer mass. Fitted Maxwell-Stefan diffusivities increase significantly with water concentration in the contact lens.
Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia
Schiavi, Costantino; Tassi, Filippo; Finzi, Alessandro; Strobbe, Ernesto; Cellini, Mauro
2016-01-01
Background Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes. Methods Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT. Results The amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0.0001) and the sound eye group (P=0.0001), but also between the latter two groups (P=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (P=0.0002), but also between the control group and the sound eye group (P=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (P=0.0001) or the sound eye group (P=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (P=0.0025) and sound (P=0.0023) eyes, but also in the healthy control group (P=0.0001). Conclusion These data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease. PMID:27799733
Czarnecki, Olaf; Peter, Enrico; Grimm, Bernhard
2011-01-01
Tetrapyrroles and carotenoids are required for many indispensable functions in photosynthesis. Tetrapyrroles are essential metabolites for photosynthesis, redox reaction, and detoxification of reactive oxygen species and xenobiotics, while carotenoids function as accessory pigments, in photoprotection and in attraction to animals. Their branched metabolic pathways of synthesis and degradation are tightly controlled to provide adequate amounts of each metabolite (carotenoids/tetrapyrroles) and to prevent accumulation of photoreactive intermediates (tetrapyrroles). Many Arabidopsis mutants and transgenic plants have been reported to show variations in steady-state levels of tetrapyrrole intermediates and contents of different carotenoid species. It is a challenging task to determine the minute amounts of these metabolites to assess the metabolic flow and the activities of both pigment-synthesising and degrading pathways, to unravel limiting enzymatic steps of these biosynthetic pathways, and to characterise mutants with accumulating intermediates. In this chapter, we present a series of methods to qualify and quantify anabolic and catabolic intermediates of Arabidopsis tetrapyrrole metabolism, and describe a common method for quantification of different plant carotenoid species. Additionally, we introduce two methods for quantification of non-covalently bound haem. The approach of analysing steady-state levels of tetrapyrrole intermediates in plants, when applied in combination with analyses of transcripts, proteins, and enzyme activities, enables the biochemical and genetic elucidation of the tetrapyrrole pathway in wild-type plants, varieties, and mutants. Steady-state levels of tetrapyrrole intermediates are only up to 1/1,000 of the amounts of the accumulating end-products, chlorophyll, and haem. Although present in very low amounts, the accumulation and availability of tetrapyrrole intermediates have major consequences on the physiology and activity of
Manhart, Michael; Haldane, Allan
2012-01-01
Monomorphic loci evolve through a series of substitutions on a fitness landscape. Understanding how mutation, selection, and genetic drift drive this process, and uncovering the structure of the fitness landscape from genomic data are two major goals of evolutionary theory. Population genetics models of the substitution process have traditionally focused on the weak-selection regime, which is accurately described by diffusion theory. Predictions in this regime can be considered universal in the sense that many population models exhibit equivalent behavior in the diffusion limit. However, a growing number of experimental studies suggest that strong selection plays a key role in some systems, and thus there is a need to understand universal properties of models without a priori assumptions about selection strength. Here we study time reversibility in a general substitution model of a monomorphic haploid population. We show that for any time-reversible population model, such as the Moran process, substitution rates obey an exact scaling law. For several other irreversible models, such as the simple Wright-Fisher process and its extensions, the scaling law is accurate up to selection strengths that are well outside the diffusion regime. Time reversibility gives rise to a power-law expression for the steady-state distribution of populations on an arbitrary fitness landscape. The steady-state behavior is dominated by weak selection and is thus adequately described by the diffusion approximation, which guarantees universality of the steady-state formula and its applicability to the problem of reconstructing fitness landscapes from DNA or protein sequence data. PMID:22838027
Collisional evolution - an analytical study for the non steady-state mass distribution.
NASA Astrophysics Data System (ADS)
Vieira Martins, R.
1999-05-01
To study the collisional evolution of asteroidal groups one can use an analytical solution for the self-similar collision cascades. This solution is suitable to study the steady-state mass distribution of the collisional fragmentation. However, out of the steady-state conditions, this solution is not satisfactory for some values of the collisional parameters. In fact, for some values for the exponent of the mass distribution power law of an asteroidal group and its relation to the exponent of the function which describes "how rocks break" the author arrives at singular points for the equation which describes the collisional evolution. These singularities appear since some approximations are usually made in the laborious evaluation of many integrals that appear in the analytical calculations. They concern the cutoff for the smallest and the largest bodies. These singularities set some restrictions to the study of the analytical solution for the collisional equation. To overcome these singularities the author performed an algebraic computation considering the smallest and the largest bodies and he obtained the analytical expressions for the integrals that describe the collisional evolution without restriction on the parameters. However, the new distribution is more sensitive to the values of the collisional parameters. In particular the steady-state solution for the differential mass distribution has exponents slightly different from 11/6 for the usual parameters in the asteroid belt. The sensitivity of this distribution with respect to the parameters is analyzed for the usual values in the asteroidal groups. With an expression for the mass distribution without singularities, one can evaluate also its time evolution. The author arrives at an analytical expression given by a power series of terms constituted by a small parameter multiplied by the mass to an exponent, which depends on the initial power law distribution. This expression is a formal solution for the
Microchemostat array with small-volume fraction replenishment for steady-state microbial culture.
Park, Jaewon; Wu, Jianzhang; Polymenis, Michael; Han, Arum
2013-11-07
A chemostat is a bioreactor in which microorganisms can be cultured at steady-state by controlling the rate of culture medium inflow and waste outflow, thus maintaining media composition over time. Even though many microbial studies could greatly benefit from studying microbes in steady-state conditions, high instrument cost, complexity, and large reagent consumption hamper the routine use of chemostats. Microfluidic-based chemostats (i.e. microchemostats) can operate with significantly smaller reagent consumption while providing accurate chemostatic conditions at orders of magnitude lower cost compared to conventional chemostats. Also, microchemostats have the potential to significantly increase the throughput by integrating arrays of microchemostats. We present a microchemostat array with a unique two-depth culture chamber design that enables small-volume fraction replenishment of culture medium as low as 1% per replenishment cycle in a 250 nl volume. A system having an array of 8 microchemostats on a 40 × 60 mm(2) footprint could be automatically operated in parallel by a single controller unit as a demonstration for potential high throughput microbial studies. The model organism, Saccharomyces cerevisiae, successfully reached a stable steady-state of different cell densities as a demonstration of the chemostatic functionality by programming the dilution rates. Chemostatic functionality of the system was further confirmed by quantifying the budding index as a function of dilution rate, a strong indicator of growth-dependent cell division. In addition, the small-volume fraction replenishment feature minimized the cell density fluctuation during the culture. The developed system provides a robust, low-cost, and higher throughput solution to furthering studies in microbial physiology.
Steady-State Diffusion of Water through Soft-Contact LensMaterials
Fornasiero, Francesco; Krull, Florian; Radke, Clayton J.; Prausnitz, JohnM.
2005-01-31
Water transport through soft contact lenses (SCL) is important for acceptable performance on the human eye. Chemical-potential gradient-driven diffusion rates of water through soft-contact-lens materials are measured with an evaporation-cell technique. Water is evaporated from the bottom surface of a lens membrane by impinging air at controlled flow rate and humidity. The resulting weight loss of a water reservoir covering the top surface of the contact-lens material is recorded as a function of time. New results are reported for a conventional hydrogel material (SofLens{trademark} One Day, hilafilcon A, water content at saturation W{sub 10} = 70 weight %) and a silicone hydrogel material (PureVision{trademark}, balafilcon A, W{sub 10} = 36 %), with and without surface oxygen plasma treatment. Also, previously reported data for a conventional HEMA-SCL (W{sub 10} = 38 %) hydrogel are reexamined and compared with those for SofLens{trademark} One Day and PureVision{trademark} hydrogels. Measured steady-state water fluxes are largest for SofLens{trademark} One Day, followed by PureVision{trademark} and HEMA. In some cases, the measured steady-state water fluxes increase with rising relative air humidity. This increase, due to an apparent mass-transfer resistance at the surface (trapping skinning), is associated with formation of a glassy skin at the air/membrane interface when the relative humidity is below 55-75%. Steady-state water-fluxes are interpreted through an extended Maxwell-Stefan diffusion model for a mixture of species starkly different in size. Thermodynamic nonideality is considered through Flory-Rehner polymer-solution theory. Shrinking/swelling is self-consistently modeled by conservation of the total polymer mass. Fitted Maxwell-Stefan diffusivities increase significantly with water concentration in the contact lens.
Determination of longitudinal aerodynamic derivatives from steady-state measurement of an aircraft
NASA Technical Reports Server (NTRS)
Klein, V.
1977-01-01
A method for the estimation of aerodynamic derivatives from steady-state symmetric flight data is developed. The derivatives considered are the longitudinal static stability and control derivatives, damping derivatives due to tail, and the derivatives expressing the speed effect on the lift and pitching moment coefficients. The method is an extension of the well known theory of longitudinal static stability and control, and corresponding flight data interpretation. Measured data is assumed in the form of trim curves and lift vs angle of attack. The expressions for the derivative estimates are in the form of algebraic relationships containing known constants, and directly or indirectly measured quantities.
Steady States and Dynamics of 2-D Nematic Polymers Driven by an Imposed Weak Shear
2007-01-01
f (0)(θ,T0,T1) is a quasi-steady state if it is independent of T0. In particu- lar , the phase angle α in (4.3) is independent of T0. However, as we...posedness for the dumbbell model of polymeric fluids, Comm. Math. Phys., 248, 409-427, 2004. [11] I. Fatkullin and V. Slastikov, A note on the Onsager ...model of nematic phase transitions, Commun. Math. Sci., 3, 21-26, 2005. [12] I. Fatkullin and V. Slastikov, Critical points of the Onsager functional
Investigation of component failure rates for pulsed versus steady state tokamak operation
Cadwallader, L.C.
1992-07-01
This report presents component failure rate data sources applicable to magnetic fusion systems, and defines multiplicative factors to adjust these data for specific use on magnetic fusion experiment designs. The multipliers address both long pulse and steady state tokamak operation. Thermal fatigue and radiation damage are among the leading reasons for large multiplier values in pulsed operation applications. Field failure rate values for graphite protective tiles are presented, and beryllium tile failure rates in laboratory testing are also given. All of these data can be used for reliability studies, safety analyses, design tradeoff studies, and risk assessments.
Interaction-stabilized steady states in the driven O (N ) model
NASA Astrophysics Data System (ADS)
Chandran, Anushya; Sondhi, S. L.
2016-05-01
We study periodically driven bosonic scalar field theories in the infinite N limit. It is well known that the free theory can undergo parametric resonance under monochromatic modulation of the mass term and thereby absorb energy indefinitely. Interactions in the infinite N limit terminate this increase for any choice of the UV cutoff and driving frequency. The steady state has nontrivial correlations and is synchronized with the drive. The O (N ) model at infinite N provides the first example of a clean interacting quantum system that does not heat to infinite temperature at any drive frequency.
The VERRUN and VERNAL software systems for steady-state visual evoked response experimentation
NASA Technical Reports Server (NTRS)
Levison, W. H.; Zacharias, G. L.
1984-01-01
Two digital computer programs were developed for use in experiments involving steady-state visual evoked response (VER): VERRUN, whose primary functions are to generate a sum-of-sines (SOS) stimulus and to digitize and store electro-cortical response; and VERNAL, which provides both time- and frequency-domain metrics of the evoked response. These programs were coded in FORTRAN for operation on the PDP-11/34, using the RSX-11 Operating System, and the PDP-11/23, using the RT-11 Operating System. Users' and programmers' guides to these programs are provided, and guidelines for model analysis of VER data are suggested.
A calculation of steady-state electrocoloration parameters of electrochromic systems
Ushakov, O.A.; Shelepin, I.V.
1986-01-01
Electrochromic systems based on solutions of compounds whichchange their color reversibly when electrochemical reactions take place may find wide applications in the design of laser-light modulators, light filters with variable optical density, and means for visual information display. It is the aim of this work to find the limiting steady-state values of current density and electrically induced optical density for electrochromic systems and to discuss possibilities of eliminating solution convection during current flow in them. During prolonged electrocoloration, the convection of anolyte and catholyte in opposite directions can lead to ''glistering'' or separation of the solution layer.
Quantitative, steady-state properties of Catania's computational model of the operant reserve.
Berg, John P; McDowell, J J
2011-05-01
Catania (2005) found that a computational model of the operant reserve (Skinner, 1938) produced realistic behavior in initial, exploratory analyses. Although Catania's operant reserve computational model demonstrated potential to simulate varied behavioral phenomena, the model was not systematically tested. The current project replicated and extended the Catania model, clarified its capabilities through systematic testing, and determined the extent to which it produces behavior corresponding to matching theory. Significant departures from both classic and modern matching theory were found in behavior generated by the model across all conditions. The results suggest that a simple, dynamic operant model of the reflex reserve does not simulate realistic steady state behavior.
A steady-state kinetic analysis of the prolyl-4-hydroxylase mechanism.
Soskel, N T; Kuby, S A
1981-01-01
Published kinetic data by Kivirikko, et al. on the prolyl-4-hydroxylase reaction have been re-evaluated using the overall steady-state velocity equation in the forward and reverse directions for an ordered ter ter kinetic mechanism. Qualitatively, the published data for prolyl-4-hydroxylase appear to fit the predicted patterns for this kinetic mechanism. More kinetic data are needed to confirm these results and to quantitate the kinetic parameters but, tentatively, the order of substrate addition would appear to be alpha-ketoglutarate, oxygen, and peptide; and the order of product release would be hydroxylated peptide (or collagen), carbon dioxide, and succinate.
Wani, Nisar A.; Jehangir, Majid; Lone, Parveen A.
2017-01-01
Purpose: To highlight the role of constructive interference steady state (CISS) magnetic resonance imaging (MRI) in the diagnosis of Tolosa-Hunt Syndrome (THS). Case Report: We describe a case of THS in a 55-year-old woman presenting with left painful opthalmoplegia that was diagnosed by CISS MRI. Patient responded to steroid treatment and the lesion resolved. Conclusion: Imaging with MRI can help in making the diagnosis of THS by demonstrating an enhancing soft tissue lesion in the cavernous sinus and orbital apex resolving with steroids. CISS MRI is a sensitive sequence for diagnosis and follow-up imaging in THS. PMID:28299013
Optomechanical self-oscillations in an anharmonic potential: engineering a nonclassical steady state
NASA Astrophysics Data System (ADS)
Grimm, Manuel; Bruder, Christoph; Lörch, Niels
2016-09-01
We study self-oscillations of an optomechanical system, where coherent mechanical oscillations are induced by a driven optical or microwave cavity, for the case of an anharmonic mechanical oscillator potential. A semiclassical analytical model is developed to characterize the limit cycle for large mechanical amplitudes corresponding to a weak nonlinearity. As a result, we predict conditions to achieve subpoissonian phonon statistics in the steady state, indicating classically forbidden behavior. We compare with numerical simulations and find very good agreement. Our model is quite general and can be applied to other physical systems such as trapped ions or superconducting circuits.
Nonequilibrium steady state transport of collective-qubit system in strong coupling regime
NASA Astrophysics Data System (ADS)
Wang, Chen; Sun, Ke-Wei
2015-11-01
We investigate the steady state photon transport in a nonequilibrium collective-qubit model. By adopting the noninteracting blip approximation, which is applicable in the strong photon-qubit coupling regime, we describe the essential contribution of indirect qubit-qubit interaction to the population distribution, mediated by the photonic baths. The linear relations of both the optimal flux and noise power with the qubits system size are obtained. Moreover, the inversed power-law style for the finite-size scaling of the optimal photon-qubit coupling strength is exhibited, which is proposed to be universal.