Large Deviations and Gallavotti-Cohen Principle for Dissipative PDEs with Rough Noise
NASA Astrophysics Data System (ADS)
Jakšić, V.; Nersesyan, V.; Pillet, C.-A.; Shirikyan, A.
2015-05-01
We study a class of dissipative PDEs perturbed by an unbounded kick force. Under some natural assumptions, the restrictions of solutions to integer times form a homogeneous Markov process. Assuming that the noise is rough with respect to the space variables and has a non-degenerate law, we prove that the system in question satisfies a large deviation principle (LDP) in τ-topology. Under some additional hypotheses, we establish a Gallavotti-Cohen type symmetry for the rate function of an entropy production functional and the strict positivity and finiteness of the mean entropy production rate in the stationary regime. The latter result is applicable to PDEs with strong nonlinear dissipation.
NASA Astrophysics Data System (ADS)
Kraaij, Richard
2016-07-01
We prove the large deviation principle (LDP) for the trajectory of a broad class of finite state mean-field interacting Markov jump processes via a general analytic approach based on viscosity solutions. Examples include generalized Ehrenfest models as well as Curie-Weiss spin flip dynamics with singular jump rates. The main step in the proof of the LDP, which is of independent interest, is the proof of the comparison principle for an associated collection of Hamilton-Jacobi equations. Additionally, we show that the LDP provides a general method to identify a Lyapunov function for the associated McKean-Vlasov equation.
Large deviations and portfolio optimization
NASA Astrophysics Data System (ADS)
Sornette, Didier
Risk control and optimal diversification constitute a major focus in the finance and insurance industries as well as, more or less consciously, in our everyday life. We present a discussion of the characterization of risks and of the optimization of portfolios that starts from a simple illustrative model and ends by a general functional integral formulation. A major item is that risk, usually thought of as one-dimensional in the conventional mean-variance approach, has to be addressed by the full distribution of losses. Furthermore, the time-horizon of the investment is shown to play a major role. We show the importance of accounting for large fluctuations and use the theory of Cramér for large deviations in this context. We first treat a simple model with a single risky asset that exemplifies the distinction between the average return and the typical return and the role of large deviations in multiplicative processes, and the different optimal strategies for the investors depending on their size. We then analyze the case of assets whose price variations are distributed according to exponential laws, a situation that is found to describe daily price variations reasonably well. Several portfolio optimization strategies are presented that aim at controlling large risks. We end by extending the standard mean-variance portfolio optimization theory, first within the quasi-Gaussian approximation and then using a general formulation for non-Gaussian correlated assets in terms of the formalism of functional integrals developed in the field theory of critical phenomena.
NASA Astrophysics Data System (ADS)
Chen, Yong; Ge, Hao; Xiong, Jie; Xu, Lihu
2016-07-01
Fluctuation theorem is one of the major achievements in the field of nonequilibrium statistical mechanics during the past two decades. There exist very few results for steady-state fluctuation theorem of sample entropy production rate in terms of large deviation principle for diffusion processes due to the technical difficulties. Here we give a proof for the steady-state fluctuation theorem of a diffusion process in magnetic fields, with explicit expressions of the free energy function and rate function. The proof is based on the Karhunen-Loève expansion of complex-valued Ornstein-Uhlenbeck process.
Large Deviations for Stochastic Evolution Equations with Small Multiplicative Noise
Liu Wei
2010-02-15
The Freidlin-Wentzell large deviation principle is established for the distributions of stochastic evolution equations with general monotone drift and small multiplicative noise. As examples, the main results are applied to derive the large deviation principle for different types of SPDE such as stochastic reaction-diffusion equations, stochastic porous media equations and fast diffusion equations, and the stochastic p-Laplace equation in Hilbert space. The weak convergence approach is employed in the proof to establish the Laplace principle, which is equivalent to the large deviation principle in our framework.
Large Deviations in Fast-Slow Systems
NASA Astrophysics Data System (ADS)
Bouchet, Freddy; Grafke, Tobias; Tangarife, Tomás; Vanden-Eijnden, Eric
2016-02-01
The incidence of rare events in fast-slow systems is investigated via analysis of the large deviation principle (LDP) that characterizes the likelihood and pathway of large fluctuations of the slow variables away from their mean behavior—such fluctuations are rare on short time-scales but become ubiquitous eventually. Classical results prove that this LDP involves an Hamilton-Jacobi equation whose Hamiltonian is related to the leading eigenvalue of the generator of the fast process, and is typically non-quadratic in the momenta—in other words, the LDP for the slow variables in fast-slow systems is different in general from that of any stochastic differential equation (SDE) one would write for the slow variables alone. It is shown here that the eigenvalue problem for the Hamiltonian can be reduced to a simpler algebraic equation for this Hamiltonian for a specific class of systems in which the fast variables satisfy a linear equation whose coefficients depend nonlinearly on the slow variables, and the fast variables enter quadratically the equation for the slow variables. These results are illustrated via examples, inspired by kinetic theories of turbulent flows and plasma, in which the quasipotential characterizing the long time behavior of the system is calculated and shown again to be different from that of an SDE.
Large Deviations for Nonlocal Stochastic Neural Fields
2014-01-01
We study the effect of additive noise on integro-differential neural field equations. In particular, we analyze an Amari-type model driven by a Q-Wiener process, and focus on noise-induced transitions and escape. We argue that proving a sharp Kramers’ law for neural fields poses substantial difficulties, but that one may transfer techniques from stochastic partial differential equations to establish a large deviation principle (LDP). Then we demonstrate that an efficient finite-dimensional approximation of the stochastic neural field equation can be achieved using a Galerkin method and that the resulting finite-dimensional rate function for the LDP can have a multiscale structure in certain cases. These results form the starting point for an efficient practical computation of the LDP. Our approach also provides the technical basis for further rigorous study of noise-induced transitions in neural fields based on Galerkin approximations. Mathematics Subject Classification (2000): 60F10, 60H15, 65M60, 92C20. PMID:24742297
Large Deviations: Advanced Probability for Undergrads
ERIC Educational Resources Information Center
Rolls, David A.
2007-01-01
In the branch of probability called "large deviations," rates of convergence (e.g. of the sample mean) are considered. The theory makes use of the moment generating function. So, particularly for sums of independent and identically distributed random variables, the theory can be made accessible to senior undergraduates after a first course in…
On large deviations for ensembles of distributions
Khrychev, D A
2013-11-30
The paper is concerned with the large deviations problem in the Freidlin-Wentzell formulation without the assumption of the uniqueness of the solution to the equation involving white noise. In other words, it is assumed that for each ε>0 the nonempty set P{sub ε} of weak solutions is not necessarily a singleton. Analogues of a number of concepts in the theory of large deviations are introduced for the set (P{sub ε}, ε>0), hereafter referred to as an ensemble of distributions. The ensembles of weak solutions of an n-dimensional stochastic Navier-Stokes system and stochastic wave equation with power-law nonlinearity are shown to be uniformly exponentially tight. An idempotent Wiener process in a Hilbert space and idempotent partial differential equations are defined. The accumulation points in the sense of large deviations of the ensembles in question are shown to be weak solutions of the corresponding idempotent equations. Bibliography: 14 titles.
Large deviations in single-file diffusion.
Krapivsky, P L; Mallick, Kirone; Sadhu, Tridib
2014-08-15
We apply macroscopic fluctuation theory to study the diffusion of a tracer in a one-dimensional interacting particle system with excluded mutual passage, known as single-file diffusion. In the case of Brownian point particles with hard-core repulsion, we derive the cumulant generating function of the tracer position and its large deviation function. In the general case of arbitrary interparticle interactions, we express the variance of the tracer position in terms of the collective transport properties, viz., the diffusion coefficient and the mobility. Our analysis applies both for fluctuating (annealed) and fixed (quenched) initial configurations.
Large Deviations in Single-File Diffusion
NASA Astrophysics Data System (ADS)
Krapivsky, P. L.; Mallick, Kirone; Sadhu, Tridib
2014-08-01
We apply macroscopic fluctuation theory to study the diffusion of a tracer in a one-dimensional interacting particle system with excluded mutual passage, known as single-file diffusion. In the case of Brownian point particles with hard-core repulsion, we derive the cumulant generating function of the tracer position and its large deviation function. In the general case of arbitrary interparticle interactions, we express the variance of the tracer position in terms of the collective transport properties, viz., the diffusion coefficient and the mobility. Our analysis applies both for fluctuating (annealed) and fixed (quenched) initial configurations.
Large deviations of the current for driven periodic diffusions
NASA Astrophysics Data System (ADS)
Tsobgni Nyawo, Pelerine; Touchette, Hugo
2016-09-01
We study the large deviations of the time-integrated current for a driven diffusion on the circle, often used as a model of nonequilibrium systems. We obtain the large deviation functions describing the current fluctuations using a Fourier-Bloch decomposition of the so-called tilted generator, and we also construct from this decomposition the effective (biased, auxiliary, or driven) Markov process describing the diffusion as current fluctuations are observed in time. This effective process provides a clear physical explanation of the various fluctuation regimes observed. It is used here to obtain an upper bound on the current large deviation function, which we compare to a recently derived entropic bound, and to study the low-noise limit of large deviations.
Path integrals and large deviations in stochastic hybrid systems
NASA Astrophysics Data System (ADS)
Bressloff, Paul C.; Newby, Jay M.
2014-04-01
We construct a path-integral representation of solutions to a stochastic hybrid system, consisting of one or more continuous variables evolving according to a piecewise-deterministic dynamics. The differential equations for the continuous variables are coupled to a set of discrete variables that satisfy a continuous-time Markov process, which means that the differential equations are only valid between jumps in the discrete variables. Examples of stochastic hybrid systems arise in biophysical models of stochastic ion channels, motor-driven intracellular transport, gene networks, and stochastic neural networks. We use the path-integral representation to derive a large deviation action principle for a stochastic hybrid system. Minimizing the associated action functional with respect to the set of all trajectories emanating from a metastable state (assuming that such a minimization scheme exists) then determines the most probable paths of escape. Moreover, evaluating the action functional along a most probable path generates the so-called quasipotential used in the calculation of mean first passage times. We illustrate the theory by considering the optimal paths of escape from a metastable state in a bistable neural network.
Large Deviation Analysis of Rapid Onset of Rain Showers.
Wilkinson, Michael
2016-01-01
Rainfall from ice-free cumulus clouds requires collisions of large numbers of microscopic droplets to create every raindrop. The onset of rain showers can be surprisingly rapid, much faster than the mean time required for a single collision. Large-deviation theory is used to explain this observation. PMID:26799046
Large Deviation Analysis of Rapid Onset of Rain Showers.
Wilkinson, Michael
2016-01-01
Rainfall from ice-free cumulus clouds requires collisions of large numbers of microscopic droplets to create every raindrop. The onset of rain showers can be surprisingly rapid, much faster than the mean time required for a single collision. Large-deviation theory is used to explain this observation.
Large Deviation Analysis of Rapid Onset of Rain Showers
NASA Astrophysics Data System (ADS)
Wilkinson, Michael
2016-01-01
Rainfall from ice-free cumulus clouds requires collisions of large numbers of microscopic droplets to create every raindrop. The onset of rain showers can be surprisingly rapid, much faster than the mean time required for a single collision. Large-deviation theory is used to explain this observation.
Large deviation theory for coin tossing and turbulence.
Chakraborty, Sagar; Saha, Arnab; Bhattacharjee, Jayanta K
2009-11-01
Large deviations play a significant role in many branches of nonequilibrium statistical physics. They are difficult to handle because their effects, though small, are not amenable to perturbation theory. Even the Gaussian model, which is the usual initial step for most perturbation theories, fails to be a starting point while discussing intermittency in fluid turbulence, where large deviations dominate. Our contention is: in the large deviation theory, the central role is played by the distribution associated with the tossing of a coin and the simple coin toss is the "Gaussian model" of problems where rare events play significant role. We illustrate this by applying it to calculate the multifractal exponents of the order structure factors in fully developed turbulence.
Large deviations of spread measures for Gaussian matrices
NASA Astrophysics Data System (ADS)
Deelan Cunden, Fabio; Vivo, Pierpaolo
2016-04-01
For a large n× m Gaussian matrix, we compute the joint statistics, including large deviation tails, of generalized and total variance—the scaled log-determinant H and trace T of the corresponding n× n covariance matrix. Using a Coulomb gas technique, we find that the Laplace transform of their joint distribution {{P}n}(h,t) decays for large n, m (with c=m/n≥slant 1 fixed) as {{\\hat{P}}n}(s,w)≈ \\exp ≤ft(-β {{n}2}J(s,w)\\right) , where β is the Dyson index of the ensemble and J(s, w) is a β-independent large deviation function, which we compute exactly for any c. The corresponding large deviation functions in real space are worked out and checked with extensive numerical simulations. The results are complemented with a finite n, m treatment based on the Laguerre–Selberg integral. The statistics of atypically small log-determinants is shown to be driven by the split-off of the smallest eigenvalue, leading to an abrupt change in the large deviation speed.
Large-deviation statistics of vorticity stretching in isotropic turbulence.
Johnson, Perry L; Meneveau, Charles
2016-03-01
A key feature of three-dimensional fluid turbulence is the stretching and realignment of vorticity by the action of the strain rate. It is shown in this paper, using the cumulant-generating function, that the cumulative vorticity stretching along a Lagrangian path in isotropic turbulence obeys a large deviation principle. As a result, the relevant statistics can be described by the vorticity stretching Cramér function. This function is computed from a direct numerical simulation data set at a Taylor-scale Reynolds number of Re(λ)=433 and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected, the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramér functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of the largest FTLE. In an attempt to relate the vorticity stretching statistics to the vorticity magnitude probability density function in statistically stationary conditions, a model Kramers-Moyal equation is constructed using the statistics encoded in the Cramér function. The model predicts a stretched-exponential tail for the vorticity magnitude probability density function, with good agreement for the exponent but significant difference (35%) in the prefactor.
Large-deviation statistics of vorticity stretching in isotropic turbulence
NASA Astrophysics Data System (ADS)
Johnson, Perry L.; Meneveau, Charles
2016-03-01
A key feature of three-dimensional fluid turbulence is the stretching and realignment of vorticity by the action of the strain rate. It is shown in this paper, using the cumulant-generating function, that the cumulative vorticity stretching along a Lagrangian path in isotropic turbulence obeys a large deviation principle. As a result, the relevant statistics can be described by the vorticity stretching Cramér function. This function is computed from a direct numerical simulation data set at a Taylor-scale Reynolds number of Reλ=433 and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected, the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramér functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of the largest FTLE. In an attempt to relate the vorticity stretching statistics to the vorticity magnitude probability density function in statistically stationary conditions, a model Kramers-Moyal equation is constructed using the statistics encoded in the Cramér function. The model predicts a stretched-exponential tail for the vorticity magnitude probability density function, with good agreement for the exponent but significant difference (35%) in the prefactor.
Large-deviation statistics of vorticity stretching in isotropic turbulence.
Johnson, Perry L; Meneveau, Charles
2016-03-01
A key feature of three-dimensional fluid turbulence is the stretching and realignment of vorticity by the action of the strain rate. It is shown in this paper, using the cumulant-generating function, that the cumulative vorticity stretching along a Lagrangian path in isotropic turbulence obeys a large deviation principle. As a result, the relevant statistics can be described by the vorticity stretching Cramér function. This function is computed from a direct numerical simulation data set at a Taylor-scale Reynolds number of Re(λ)=433 and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected, the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramér functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of the largest FTLE. In an attempt to relate the vorticity stretching statistics to the vorticity magnitude probability density function in statistically stationary conditions, a model Kramers-Moyal equation is constructed using the statistics encoded in the Cramér function. The model predicts a stretched-exponential tail for the vorticity magnitude probability density function, with good agreement for the exponent but significant difference (35%) in the prefactor. PMID:27078458
Deviations from Newton's law in supersymmetric large extra dimensions
NASA Astrophysics Data System (ADS)
Callin, P.; Burgess, C. P.
2006-09-01
Deviations from Newton's inverse-squared law at the micron length scale are smoking-gun signals for models containing supersymmetric large extra dimensions (SLEDs), which have been proposed as approaches for resolving the cosmological constant problem. Just like their non-supersymmetric counterparts, SLED models predict gravity to deviate from the inverse-square law because of the advent of new dimensions at sub-millimeter scales. However SLED models differ from their non-supersymmetric counterparts in three important ways: (i) the size of the extra dimensions is fixed by the observed value of the dark energy density, making it impossible to shorten the range over which new deviations from Newton's law must be seen; (ii) supersymmetry predicts there to be more fields in the extra dimensions than just gravity, implying different types of couplings to matter and the possibility of repulsive as well as attractive interactions; and (iii) the same mechanism which is purported to keep the cosmological constant naturally small also keeps the extra-dimensional moduli effectively massless, leading to deviations from general relativity in the far infrared of the scalar-tensor form. We here explore the deviations from Newton's law which are predicted over micron distances, and show the ways in which they differ and resemble those in the non-supersymmetric case.
Large Deviations for the Two-Dimensional Two-Component Plasma
NASA Astrophysics Data System (ADS)
Leblé, Thomas; Serfaty, Sylvia; Zeitouni, Ofer
2016-08-01
We derive a large deviations principle for the two-dimensional two-component plasma in a box. As a consequence, we obtain a variational representation for the free energy, and also show that the macroscopic empirical measure of either positive or negative charges converges to the uniform measure. An appendix, written by Wei Wu, discusses applications to the subcritical complex Gaussian multiplicative chaos.
Large deviation function of the partially asymmetric exclusion process.
Lee, D S; Kim, D
1999-06-01
The large deviation function obtained recently by Derrida and Lebowitz [Phys. Rev. Lett. 80, 209 (1998)] for the totally asymmetric exclusion process is generalized to the partially asymmetric case in the scaling limit. The asymmetry parameter rescales the scaling variable in a simple way. The finite-size corrections to the universal scaling function and the universal cumulant ratio are also obtained to the leading order. PMID:11969632
Large deviation statistics of non-equilibrium fluctuations in a sheared model-fluid
NASA Astrophysics Data System (ADS)
Dolai, Pritha; Simha, Aditi
2016-08-01
We analyse the statistics of the shear stress in a one dimensional model fluid, that exhibits a rich phase behaviour akin to real complex fluids under shear. We show that the energy flux satisfies the Gallavotti-Cohen FT across all phases in the system. The theorem allows us to define an effective temperature which deviates considerably from the equilibrium temperature as the noise in the system increases. This deviation is negligible when the system size is small. The dependence of the effective temperature on the strain rate is phase-dependent. It doesn’t vary much at the phase boundaries. The effective temperature can also be determined from the large deviation function of the energy flux. The local strain rate statistics obeys the large deviation principle and satisfies a fluctuation relation. It does not exhibit a distinct kink near zero strain rate because of inertia of the rotors in our system.
Large deviation approach to the generalized random energy model
NASA Astrophysics Data System (ADS)
Dorlas, T. C.; Dukes, W. M. B.
2002-05-01
The generalized random energy model is a generalization of the random energy model introduced by Derrida to mimic the ultrametric structure of the Parisi solution of the Sherrington-Kirkpatrick model of a spin glass. It was solved exactly in two special cases by Derrida and Gardner. A complete solution for the thermodynamics in the general case was given by Capocaccia et al. Here we use large deviation theory to analyse the model in a very straightforward way. We also show that the variational expression for the free energy can be evaluated easily using the Cauchy-Schwarz inequality.
Large deviation analysis of a simple information engine
NASA Astrophysics Data System (ADS)
Maitland, Michael; Grosskinsky, Stefan; Harris, Rosemary J.
2015-11-01
Information thermodynamics provides a framework for studying the effect of feedback loops on entropy production. It has enabled the understanding of novel thermodynamic systems such as the information engine, which can be seen as a modern version of "Maxwell's Dæmon," whereby a feedback controller processes information gained by measurements in order to extract work. Here, we analyze a simple model of such an engine that uses feedback control based on measurements to obtain negative entropy production. We focus on the distribution and fluctuations of the information obtained by the feedback controller. Significantly, our model allows an analytic treatment for a two-state system with exact calculation of the large deviation rate function. These results suggest an approximate technique for larger systems, which is corroborated by simulation data.
Large deviation analysis of a simple information engine.
Maitland, Michael; Grosskinsky, Stefan; Harris, Rosemary J
2015-11-01
Information thermodynamics provides a framework for studying the effect of feedback loops on entropy production. It has enabled the understanding of novel thermodynamic systems such as the information engine, which can be seen as a modern version of "Maxwell's Dæmon," whereby a feedback controller processes information gained by measurements in order to extract work. Here, we analyze a simple model of such an engine that uses feedback control based on measurements to obtain negative entropy production. We focus on the distribution and fluctuations of the information obtained by the feedback controller. Significantly, our model allows an analytic treatment for a two-state system with exact calculation of the large deviation rate function. These results suggest an approximate technique for larger systems, which is corroborated by simulation data. PMID:26651675
From the Law of Large Numbers to Large Deviation Theory in Statistical Physics: An Introduction
NASA Astrophysics Data System (ADS)
Cecconi, Fabio; Cencini, Massimo; Puglisi, Andrea; Vergni, Davide; Vulpiani, Angelo
This contribution aims at introducing the topics of this book. We start with a brief historical excursion on the developments from the law of large numbers to the central limit theorem and large deviations theory. The same topics are then presented using the language of probability theory. Finally, some applications of large deviations theory in physics are briefly discussed through examples taken from statistical mechanics, dynamical and disordered systems.
Large Deviations, Dynamics and Phase Transitions in Large Stochastic and Disordered Neural Networks
NASA Astrophysics Data System (ADS)
Cabana, Tanguy; Touboul, Jonathan
2013-10-01
Neuronal networks are characterized by highly heterogeneous connectivity, and this disorder was recently related experimentally to qualitative properties of the network. The motivation of this paper is to mathematically analyze the role of these disordered connectivities on the large-scale properties of neuronal networks. To this end, we analyze here large-scale limit behaviors of neural networks including, for biological relevance, multiple populations, random connectivities and interaction delays. Due to the randomness of the connectivity, usual mean-field methods (e.g. coupling) cannot be applied, but, similarly to studies developed for spin glasses, we will show that the sequences of empirical measures satisfy a large deviation principle, and converge towards a self-consistent non-Markovian process. From a mathematical viewpoint, the proof differs from previous works in that we are working in infinite-dimensional spaces (interaction delays) and consider multiple cell types. The limit obtained formally characterizes the macroscopic behavior of the network. We propose a dynamical systems approach in order to address the qualitative nature of the solutions of these very complex equations, and apply this methodology to three instances in order to show how non-centered coefficients, interaction delays and multiple populations networks are affected by disorder levels. We identify a number of phase transitions in such systems upon changes in delays, connectivity patterns and dispersion, and particularly focus on the emergence of non-equilibrium states involving synchronized oscillations.
Irreversible Langevin samplers and variance reduction: a large deviations approach
NASA Astrophysics Data System (ADS)
Rey-Bellet, Luc; Spiliopoulos, Konstantinos
2015-07-01
In order to sample from a given target distribution (often of Gibbs type), the Monte Carlo Markov chain method consists of constructing an ergodic Markov process whose invariant measure is the target distribution. By sampling the Markov process one can then compute, approximately, expectations of observables with respect to the target distribution. Often the Markov processes used in practice are time-reversible (i.e. they satisfy detailed balance), but our main goal here is to assess and quantify how the addition of a non-reversible part to the process can be used to improve the sampling properties. We focus on the diffusion setting (overdamped Langevin equations) where the drift consists of a gradient vector field as well as another drift which breaks the reversibility of the process but is chosen to preserve the Gibbs measure. In this paper we use the large deviation rate function for the empirical measure as a tool to analyze the speed of convergence to the invariant measure. We show that the addition of an irreversible drift leads to a larger rate function and it strictly improves the speed of convergence of ergodic average for (generic smooth) observables. We also deduce from this result that the asymptotic variance decreases under the addition of the irreversible drift and we give an explicit characterization of the observables whose variance is not reduced reduced, in terms of a nonlinear Poisson equation. Our theoretical results are illustrated and supplemented by numerical simulations.
Large Deviations Techniques for Long-Range Interactions
NASA Astrophysics Data System (ADS)
Patelli, Aurelio; Ruffo, Stefano
After a brief introduction to the main equilibrium features of long-range interacting systems (ensemble inequivalence, negative specific heat and susceptibility, broken ergodicity, etc.) and a recall of Cramèr's theorem, we discuss in this chapter a general method which allows us to compute microcanonical entropy for systems of the mean-field type. The method consists in expressing the Hamiltonian in terms of global variables and, then, in computing the phase-space volume by fixing a value for these variables: this is done by using large deviations. The calculation of entropy as a function of energy is, thus, reformulated as the solution of a variational problem. We show the power of the method by explicitly deriving the equilibrium thermodynamic properties of the three-state Potts model, the Blume-Capel model, an XY spin system, the ϕ 4 model and the Colson-Bonifacio model of the free electron laser. When short range interactions coexist with long-range ones, the method cannot be straightforwardly applied. We discuss an alternative variational method which allows us to solve the XY model with both mean-field and nearest neighbor interactions.
De Roeck, W. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Maes, C. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Schütz, M. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be; Netočný, K. E-mail: christian.maes@fys.kuleuven.be E-mail: marius.schutz@fys.kuleuven.be
2015-02-15
We study the projection on classical spins starting from quantum equilibria. We show Gibbsianness or quasi-locality of the resulting classical spin system for a class of gapped quantum systems at low temperatures including quantum ground states. A consequence of Gibbsianness is the validity of a large deviation principle in the quantum system which is known and here recovered in regimes of high temperature or for thermal states in one dimension. On the other hand, we give an example of a quantum ground state with strong nonlocality in the classical restriction, giving rise to what we call measurement induced entanglement and still satisfying a large deviation principle.
Large Deviations and Importance Sampling for Systems of Slow-Fast Motion
Spiliopoulos, Konstantinos
2013-02-15
In this paper we develop the large deviations principle and a rigorous mathematical framework for asymptotically efficient importance sampling schemes for general, fully dependent systems of stochastic differential equations of slow and fast motion with small noise in the slow component. We assume periodicity with respect to the fast component. Depending on the interaction of the fast scale with the smallness of the noise, we get different behavior. We examine how one range of interaction differs from the other one both for the large deviations and for the importance sampling. We use the large deviations results to identify asymptotically optimal importance sampling schemes in each case. Standard Monte Carlo schemes perform poorly in the small noise limit. In the presence of multiscale aspects one faces additional difficulties and straightforward adaptation of importance sampling schemes for standard small noise diffusions will not produce efficient schemes. It turns out that one has to consider the so called cell problem from the homogenization theory for Hamilton-Jacobi-Bellman equations in order to guarantee asymptotic optimality. We use stochastic control arguments.
NASA Astrophysics Data System (ADS)
Teodorescu, Razvan
2009-10-01
Systems of oscillators coupled non-linearly (stochastically or not) are ubiquitous in nature and can explain many complex phenomena: coupled Josephson junction arrays, cardiac pacemaker cells, swarms or flocks of insects and birds, etc. They are know to have a non-trivial phase diagram, which includes chaotic, partially synchronized, and fully synchronized phases. A traditional model for this class of problems is the Kuramoto system of oscillators, which has been studied extensively for the last three decades. The model is a canonical example for non-equilibrium, dynamical phase transitions, so little understood in physics. From a stochastic analysis point of view, the transition is described by the large deviations principle, which offers little information on the scaling behavior near the critical point. I will discuss a special case of the model, which allows a rigorous analysis of the critical properties of the model, and reveals a new, anomalous scaling behavior in the vicinity of the critical point.
Back in the saddle: large-deviation statistics of the cosmic log-density field
NASA Astrophysics Data System (ADS)
Uhlemann, C.; Codis, S.; Pichon, C.; Bernardeau, F.; Reimberg, P.
2016-08-01
We present a first principle approach to obtain analytical predictions for spherically averaged cosmic densities in the mildly non-linear regime that go well beyond what is usually achieved by standard perturbation theory. A large deviation principle allows us to compute the leading order cumulants of average densities in concentric cells. In this symmetry, the spherical collapse model leads to cumulant generating functions that are robust for finite variances and free of critical points when logarithmic density transformations are implemented. They yield in turn accurate density probability distribution functions (PDFs) from a straightforward saddle-point approximation valid for all density values. Based on this easy-to-implement modification, explicit analytic formulas for the evaluation of the one- and two-cell PDF are provided. The theoretical predictions obtained for the PDFs are accurate to a few per cent compared to the numerical integration, regardless of the density under consideration and in excellent agreement with N-body simulations for a wide range of densities. This formalism should prove valuable for accurately probing the quasi-linear scales of low-redshift surveys for arbitrary primordial power spectra.
Two-scale large deviations for chemical reaction kinetics through second quantization path integral
NASA Astrophysics Data System (ADS)
Li, Tiejun; Lin, Feng
2016-04-01
Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second quantization path integral technique. We get three important types of large deviation results when the underlying two timescales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by the path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes.
Large deviations of the shifted index number in the Gaussian ensemble
NASA Astrophysics Data System (ADS)
Pérez Castillo, Isaac
2016-06-01
We show that, using the Coulomb fluid approach, we are able to derive a rate function \\Psi(c,x) of two variables that captures: (i) the large deviations of bulk eigenvalues; (ii) the large deviations of extreme eigenvalues (both left and right large deviations); (iii) the statistics of the fraction c of eigenvalues to the left of a position x. Thus, \\Psi(c,x) explains the full order statistics of the eigenvalues of large random Gaussian matrices as well as the statistics of the shifted index number. All our analytical findings are thoroughly compared with Monte Carlo simulations, obtaining excellent agreement. A summary of preliminary results has already been presented in Pérez Castillo (2014 Phys. Rev. E 90 040102) in the context of one-dimensional trapped spinless fermions in a harmonic potential.
Large Deviations of the Maximum Eigenvalue for Wishart and Gaussian Random Matrices
Majumdar, Satya N.; Vergassola, Massimo
2009-02-13
We present a Coulomb gas method to calculate analytically the probability of rare events where the maximum eigenvalue of a random matrix is much larger than its typical value. The large deviation function that characterizes this probability is computed explicitly for Wishart and Gaussian ensembles. The method is general and applies to other related problems, e.g., the joint large deviation function for large fluctuations of top eigenvalues. Our results are relevant to widely employed data compression techniques, namely, the principal components analysis. Analytical predictions are verified by extensive numerical simulations.
Efficiency and large deviations in time-asymmetric stochastic heat engines
Gingrich, Todd R.; Rotskoff, Grant M.; Vaikuntanathan, Suriyanarayanan; Geissler, Phillip L.
2014-10-24
In a stochastic heat engine driven by a cyclic non-equilibrium protocol, fluctuations in work and heat give rise to a fluctuating efficiency. Using computer simulations and tools from large deviation theory, we have examined these fluctuations in detail for a model two-state engine. We find in general that the form of efficiency probability distributions is similar to those described by Verley et al (2014 Nat. Commun. 5 4721), in particular featuring a local minimum in the long-time limit. In contrast to the time-symmetric engine protocols studied previously, however, this minimum need not occur at the value characteristic of a reversible Carnot engine. Furthermore, while the local minimum may reside at the global minimum of a large deviation rate function, it does not generally correspond to the least likely efficiency measured over finite time. Lastly, we introduce a general approximation for the finite-time efficiency distribution, $P(\\eta )$, based on large deviation statistics of work and heat, that remains very accurate even when $P(\\eta )$ deviates significantly from its large deviation form.
Efficiency and large deviations in time-asymmetric stochastic heat engines
Gingrich, Todd R.; Rotskoff, Grant M.; Vaikuntanathan, Suriyanarayanan; Geissler, Phillip L.
2014-10-24
In a stochastic heat engine driven by a cyclic non-equilibrium protocol, fluctuations in work and heat give rise to a fluctuating efficiency. Using computer simulations and tools from large deviation theory, we have examined these fluctuations in detail for a model two-state engine. We find in general that the form of efficiency probability distributions is similar to those described by Verley et al (2014 Nat. Commun. 5 4721), in particular featuring a local minimum in the long-time limit. In contrast to the time-symmetric engine protocols studied previously, however, this minimum need not occur at the value characteristic of a reversible Carnot engine. Furthermore, while the local minimum may reside at the global minimum of a large deviation rate function, it does not generally correspond to the least likely efficiency measured over finite time. Lastly, we introduce a general approximation for the finite-time efficiency distribution,more » $$P(\\eta )$$, based on large deviation statistics of work and heat, that remains very accurate even when $$P(\\eta )$$ deviates significantly from its large deviation form.« less
Dispersion in Rectangular Networks: Effective Diffusivity and Large-Deviation Rate Function
NASA Astrophysics Data System (ADS)
Tzella, Alexandra; Vanneste, Jacques
2016-09-01
The dispersion of a diffusive scalar in a fluid flowing through a network has many applications including to biological flows, porous media, water supply, and urban pollution. Motivated by this, we develop a large-deviation theory that predicts the evolution of the concentration of a scalar released in a rectangular network in the limit of large time t ≫1 . This theory provides an approximation for the concentration that remains valid for large distances from the center of mass, specifically for distances up to O (t ) and thus much beyond the O (t1 /2) range where a standard Gaussian approximation holds. A byproduct of the approach is a closed-form expression for the effective diffusivity tensor that governs this Gaussian approximation. Monte Carlo simulations of Brownian particles confirm the large-deviation results and demonstrate their effectiveness in describing the scalar distribution when t is only moderately large.
Dispersion in Rectangular Networks: Effective Diffusivity and Large-Deviation Rate Function.
Tzella, Alexandra; Vanneste, Jacques
2016-09-01
The dispersion of a diffusive scalar in a fluid flowing through a network has many applications including to biological flows, porous media, water supply, and urban pollution. Motivated by this, we develop a large-deviation theory that predicts the evolution of the concentration of a scalar released in a rectangular network in the limit of large time t≫1. This theory provides an approximation for the concentration that remains valid for large distances from the center of mass, specifically for distances up to O(t) and thus much beyond the O(t^{1/2}) range where a standard Gaussian approximation holds. A byproduct of the approach is a closed-form expression for the effective diffusivity tensor that governs this Gaussian approximation. Monte Carlo simulations of Brownian particles confirm the large-deviation results and demonstrate their effectiveness in describing the scalar distribution when t is only moderately large. PMID:27661692
Dispersion in Rectangular Networks: Effective Diffusivity and Large-Deviation Rate Function.
Tzella, Alexandra; Vanneste, Jacques
2016-09-01
The dispersion of a diffusive scalar in a fluid flowing through a network has many applications including to biological flows, porous media, water supply, and urban pollution. Motivated by this, we develop a large-deviation theory that predicts the evolution of the concentration of a scalar released in a rectangular network in the limit of large time t≫1. This theory provides an approximation for the concentration that remains valid for large distances from the center of mass, specifically for distances up to O(t) and thus much beyond the O(t^{1/2}) range where a standard Gaussian approximation holds. A byproduct of the approach is a closed-form expression for the effective diffusivity tensor that governs this Gaussian approximation. Monte Carlo simulations of Brownian particles confirm the large-deviation results and demonstrate their effectiveness in describing the scalar distribution when t is only moderately large.
First-Principle Calculations of Large Fullerenes.
Calaminici, Patrizia; Geudtner, Gerald; Köster, Andreas M
2009-01-13
State of-the-art density functional theory calculations have been performed for the large fullerenes C180, C240, C320, and C540 using the linear combination of Gaussian-type orbitals density functional theory (LCGTO-DFT) approach. For the calculations all-electron basis sets were employed. All fullerene structures were fully optimized without symmetry constrains. The analysis of the obtained structures as well as a study on the evolution of the bond lengths and calculated binding energies are presented. The fullerene results are compared to diamond and graphene which were calculated at the same level of theory. This represents the first systematic study on these large fullerenes based on nonsymmetry adapted first-principle calculations, and it demonstrates the capability of DFT calculations for energy and structure computations of large scale structures without any symmetry constraint.
Wang, Wanlin; Zhang, Wang; Chen, Weixin; Gu, Jiajun; Liu, Qinglei; Deng, Tao; Zhang, Di
2013-01-15
The wide angular range of the treelike structure in Morpho butterfly scales was investigated by finite-difference time-domain (FDTD)/particle-swarm-optimization (PSO) analysis. Using the FDTD method, different parameters in the Morpho butterflies' treelike structure were studied and their contributions to the angular dependence were analyzed. Then a wide angular range was realized by the PSO method from quantitatively designing the lamellae deviation (Δy), which was a crucial parameter with angular range. The field map of the wide-range reflection in a large area was given to confirm the wide angular range. The tristimulus values and corresponding color coordinates for various viewing directions were calculated to confirm the blue color in different observation angles. The wide angular range realized by the FDTD/PSO method will assist us in understanding the scientific principles involved and also in designing artificial optical materials.
Large deviations for the height in 1D Kardar-Parisi-Zhang growth at late times
NASA Astrophysics Data System (ADS)
Le Doussal, Pierre; Majumdar, Satya N.; Schehr, Grégory
2016-03-01
We study the atypically large deviations of the height H∼O}(t) at the origin at late times in (1 + 1)-dimensional growth models belonging to the Kardar-Parisi-Zhang (KPZ) universality class. We present exact results for the rate functions for the discrete single-step growth model, as well as for the continuum KPZ equation in a droplet geometry. Based on our exact calculation of the rate functions we argue that models in the KPZ class undergo a third-order phase transition from a strong-coupling to a weak-coupling phase, at late times.
NASA Astrophysics Data System (ADS)
Chulaevsky, Victor
2016-09-01
We study a class of Anderson Hamiltonians with heavy-tailed independent and identically distributed random potential on graphs with sub-exponential growth of the balls and of the number of self-avoiding paths connecting pairs of points. We show that for a class of marginal distributions, Anderson localization occurs non-perturbatively, i.e., for any nonzero amplitude of the potential, like in one-dimensional systems. The proof is based on the moment analysis of the Green functions via large deviations estimates.
Universal large deviations for the tagged particle in single-file motion.
Hegde, Chaitra; Sabhapandit, Sanjib; Dhar, Abhishek
2014-09-19
We consider a gas of point particles moving in a one-dimensional channel with a hard-core interparticle interaction that prevents particle crossings--this is called single-file motion. Starting from equilibrium initial conditions we observe the motion of a tagged particle. It is well known that if the individual particle dynamics is diffusive, then the tagged particle motion is subdiffusive, while for ballistic particle dynamics, the tagged particle motion is diffusive. Here we compute the exact large deviation function for the tagged particle displacement and show that this is universal, independent of the individual dynamics.
Universal Large Deviations for the Tagged Particle in Single-File Motion
NASA Astrophysics Data System (ADS)
Hegde, Chaitra; Sabhapandit, Sanjib; Dhar, Abhishek
2014-09-01
We consider a gas of point particles moving in a one-dimensional channel with a hard-core interparticle interaction that prevents particle crossings—this is called single-file motion. Starting from equilibrium initial conditions we observe the motion of a tagged particle. It is well known that if the individual particle dynamics is diffusive, then the tagged particle motion is subdiffusive, while for ballistic particle dynamics, the tagged particle motion is diffusive. Here we compute the exact large deviation function for the tagged particle displacement and show that this is universal, independent of the individual dynamics.
Quadratic and rate-independent limits for a large-deviations functional
NASA Astrophysics Data System (ADS)
Bonaschi, Giovanni A.; Peletier, Mark A.
2016-07-01
We construct a stochastic model showing the relationship between noise, gradient flows and rate-independent systems. The model consists of a one-dimensional birth-death process on a lattice, with rates derived from Kramers' law as an approximation of a Brownian motion on a wiggly energy landscape. Taking various limits, we show how to obtain a whole family of generalized gradient flows, ranging from quadratic to rate-independent ones, connected via ` L log L' gradient flows. This is achieved via Mosco-convergence of the renormalized large-deviations rate functional of the stochastic process.
A large deviation analysis on the near-equivalence between external and internal reservoirs
NASA Astrophysics Data System (ADS)
Medeiros, João R.; Duarte Queirós, Sílvio M.
2016-06-01
Within the spirit of van Kampen's "Langevin approach", we discuss the limits of validity of rephrasing the non-equilibrium problem of a particle subject to an external (work) reservoir-a system where the fluctuation-dissipation relation is not verified-into the simpler case with an internal (heat) reservoir for which the fluctuations and the dissipation arise from the same source. Using a convenient mapping of the thermomechanical parameters we show that, counter-intuitively, such approach is not only valid for steady state time independent quantities, but also for time dependent thermostatistical quantities, namely the injected and dissipated fluxes. We connect this result with the problem of large deviations and conclude that, in this context, we can only distinguish reservoirs by analysing the "fluctuations of accumulated fluctuations". As a by-product, we learn that the best reference approximation to the large deviation functions of a non-Markovian external reservoir system is not the respective internal reservoir limit-as often assumed and suggested by the Langevin approach-but its internal reservoir analogue system obtained from the mapping of the original thermomechanical parameters.
Level 2 and level 2.5 large deviation functionals for systems with and without detailed balance
NASA Astrophysics Data System (ADS)
Hoppenau, J.; Nickelsen, D.; Engel, A.
2016-08-01
Large deviation functions are an essential tool in the statistics of rare events. Often they can be obtained by contraction from a so-called level 2 or level 2.5 large deviation functional characterizing the empirical density and current of the underlying stochastic process. For Langevin systems obeying detailed balance, the explicit form of the level 2 functional has been known ever since the mathematical work of Donsker and Varadhan. We rederive the Donsker–Varadhan result using stochastic path-integrals. We than generalize the derivation to level 2.5 large deviation functionals for non-equilibrium steady states and elucidate the relation between the large deviation functionals and different notions of entropy production in stochastic thermodynamics. Finally, we discuss some aspects of the contractions to level 1 large deviation functions and illustrate our findings with examples.
A Quantitative Evaluation of the Flipped Classroom in a Large Lecture Principles of Economics Course
ERIC Educational Resources Information Center
Balaban, Rita A.; Gilleskie, Donna B.; Tran, Uyen
2016-01-01
This research provides evidence that the flipped classroom instructional format increases student final exam performance, relative to the traditional instructional format, in a large lecture principles of economics course. The authors find that the flipped classroom directly improves performance by 0.2 to 0.7 standardized deviations, depending on…
Large Deviations of Surface Height in the Kardar-Parisi-Zhang Equation
NASA Astrophysics Data System (ADS)
Meerson, Baruch; Katzav, Eytan; Vilenkin, Arkady
2016-02-01
Using the weak-noise theory, we evaluate the probability distribution P (H ,t ) of large deviations of height H of the evolving surface height h (x ,t ) in the Kardar-Parisi-Zhang equation in one dimension when starting from a flat interface. We also determine the optimal history of the interface, conditioned on reaching the height H at time t . We argue that the tails of P behave, at arbitrary time t >0 , and in a proper moving frame, as -ln P ˜|H |5 /2 and ˜|H |3/2. The 3 /2 tail coincides with the asymptotic of the Gaussian orthogonal ensemble Tracy-Widom distribution, previously observed at long times.
NASA Astrophysics Data System (ADS)
Ge, Hao; Qian, Hong
2012-09-01
Analytical (rational) mechanics is the mathematical structure of Newtonian deterministic dynamics developed by D'Alembert, Lagrange, Hamilton, Jacobi, and many other luminaries of applied mathematics. Diffusion as a stochastic process of an overdamped individual particle immersed in a fluid, initiated by Einstein, Smoluchowski, Langevin and Wiener, has no momentum since its path is nowhere differentiable. In this exposition, we illustrate how analytical mechanics arises in stochastic dynamics from a randomly perturbed ordinary differential equation dXt = b(Xt)dt+ɛdWt, where Wt is a Brownian motion. In the limit of vanishingly small ɛ, the solution to the stochastic differential equation other than ˙ {x} = b(x) are all rare events. However, conditioned on an occurrence of such an event, the most probable trajectory of the stochastic motion is the solution to Lagrangian mechanics with L = \\Vert ˙ {q}-b(q)\\Vert 2/4 and Hamiltonian equations with H(p, q) = \\dvbr p\\dvbr2+b(q)ṡp. Hamiltonian conservation law implies that the most probable trajectory for a "rare" event has a uniform "excess kinetic energy" along its path. Rare events can also be characterized by the principle of large deviations which expresses the probability density function for Xt as f(x, t) = e-u(x, t)/ɛ, where u(x, t) is called a large-deviation rate function which satisfies the corresponding Hamilton-Jacobi equation. An irreversible diffusion process with ∇×b≠0 corresponds to a Newtonian system with a Lorentz force ḋ {q} = (∇ × b)× ˙ {q}+({1}/{2})∇ \\Vert b\\Vert 2. The connection between stochastic motion and analytical mechanics can be explored in terms of various techniques of applied mathematics, for example, singular perturbations, viscosity solutions and integrable systems.
Large Deviations of Radial Statistics in the Two-Dimensional One-Component Plasma
NASA Astrophysics Data System (ADS)
Cunden, Fabio Deelan; Mezzadri, Francesco; Vivo, Pierpaolo
2016-09-01
The two-dimensional one-component plasma is an ubiquitous model for several vortex systems. For special values of the coupling constant β q^2 (where q is the particles charge and β the inverse temperature), the model also corresponds to the eigenvalues distribution of normal matrix models. Several features of the system are discussed in the limit of large number N of particles for generic values of the coupling constant. We show that the statistics of a class of radial observables produces a rich phase diagram, and their asymptotic behaviour in terms of large deviation functions is calculated explicitly, including next-to-leading terms up to order 1 / N. We demonstrate a split-off phenomenon associated to atypical fluctuations of the edge density profile. We also show explicitly that a failure of the fluid phase assumption of the plasma can break a genuine 1 / N-expansion of the free energy. Our findings are corroborated by numerical comparisons with exact finite- N formulae valid for β q^2=2.
Large-deviation joint statistics of the finite-time Lyapunov spectrum in isotropic turbulence
NASA Astrophysics Data System (ADS)
Johnson, Perry L.; Meneveau, Charles
2015-08-01
One of the hallmarks of turbulent flows is the chaotic behavior of fluid particle paths with exponentially growing separation among them while their distance does not exceed the viscous range. The maximal (positive) Lyapunov exponent represents the average strength of the exponential growth rate, while fluctuations in the rate of growth are characterized by the finite-time Lyapunov exponents (FTLEs). In the last decade or so, the notion of Lagrangian coherent structures (which are often computed using FTLEs) has gained attention as a tool for visualizing coherent trajectory patterns in a flow and distinguishing regions of the flow with different mixing properties. A quantitative statistical characterization of FTLEs can be accomplished using the statistical theory of large deviations, based on the so-called Cramér function. To obtain the Cramér function from data, we use both the method based on measuring moments and measuring histograms and introduce a finite-size correction to the histogram-based method. We generalize the existing univariate formalism to the joint distributions of the two FTLEs needed to fully specify the Lyapunov spectrum in 3D flows. The joint Cramér function of turbulence is measured from two direct numerical simulation datasets of isotropic turbulence. Results are compared with joint statistics of FTLEs computed using only the symmetric part of the velocity gradient tensor, as well as with joint statistics of instantaneous strain-rate eigenvalues. When using only the strain contribution of the velocity gradient, the maximal FTLE nearly doubles in magnitude, highlighting the role of rotation in de-correlating the fluid deformations along particle paths. We also extend the large-deviation theory to study the statistics of the ratio of FTLEs. The most likely ratio of the FTLEs λ1 : λ2 : λ3 is shown to be about 4:1:-5, compared to about 8:3:-11 when using only the strain-rate tensor for calculating fluid volume deformations. The results
Large-deviation joint statistics of the finite-time Lyapunov spectrum in isotropic turbulence
Johnson, Perry L. Meneveau, Charles
2015-08-15
One of the hallmarks of turbulent flows is the chaotic behavior of fluid particle paths with exponentially growing separation among them while their distance does not exceed the viscous range. The maximal (positive) Lyapunov exponent represents the average strength of the exponential growth rate, while fluctuations in the rate of growth are characterized by the finite-time Lyapunov exponents (FTLEs). In the last decade or so, the notion of Lagrangian coherent structures (which are often computed using FTLEs) has gained attention as a tool for visualizing coherent trajectory patterns in a flow and distinguishing regions of the flow with different mixing properties. A quantitative statistical characterization of FTLEs can be accomplished using the statistical theory of large deviations, based on the so-called Cramér function. To obtain the Cramér function from data, we use both the method based on measuring moments and measuring histograms and introduce a finite-size correction to the histogram-based method. We generalize the existing univariate formalism to the joint distributions of the two FTLEs needed to fully specify the Lyapunov spectrum in 3D flows. The joint Cramér function of turbulence is measured from two direct numerical simulation datasets of isotropic turbulence. Results are compared with joint statistics of FTLEs computed using only the symmetric part of the velocity gradient tensor, as well as with joint statistics of instantaneous strain-rate eigenvalues. When using only the strain contribution of the velocity gradient, the maximal FTLE nearly doubles in magnitude, highlighting the role of rotation in de-correlating the fluid deformations along particle paths. We also extend the large-deviation theory to study the statistics of the ratio of FTLEs. The most likely ratio of the FTLEs λ{sub 1} : λ{sub 2} : λ{sub 3} is shown to be about 4:1:−5, compared to about 8:3:−11 when using only the strain-rate tensor for calculating fluid volume
Large Deviation Function for the Number of Eigenvalues of Sparse Random Graphs Inside an Interval.
Metz, Fernando L; Pérez Castillo, Isaac
2016-09-01
We present a general method to obtain the exact rate function Ψ_{[a,b]}(k) controlling the large deviation probability Prob[I_{N}[a,b]=kN]≍e^{-NΨ_{[a,b]}(k)} that an N×N sparse random matrix has I_{N}[a,b]=kN eigenvalues inside the interval [a,b]. The method is applied to study the eigenvalue statistics in two distinct examples: (i) the shifted index number of eigenvalues for an ensemble of Erdös-Rényi graphs and (ii) the number of eigenvalues within a bounded region of the spectrum for the Anderson model on regular random graphs. A salient feature of the rate function in both cases is that, unlike rotationally invariant random matrices, it is asymmetric with respect to its minimum. The asymmetric character depends on the disorder in a way that is compatible with the distinct eigenvalue statistics corresponding to localized and delocalized eigenstates. The results also show that the level compressibility κ_{2}/κ_{1} for the Anderson model on a regular graph satisfies 0<κ_{2}/κ_{1}<1 in the bulk regime, in contrast with the behavior found in Gaussian random matrices. Our theoretical findings are thoroughly compared to numerical diagonalization in both cases, showing a reasonable good agreement. PMID:27636476
Dynamical phase transition in large-deviation statistics of the Kardar-Parisi-Zhang equation
NASA Astrophysics Data System (ADS)
Janas, Michael; Kamenev, Alex; Meerson, Baruch
2016-09-01
We study the short-time behavior of the probability distribution P (H ,t ) of the surface height h (x =0 ,t )=H in the Kardar-Parisi-Zhang (KPZ) equation in 1 +1 dimension. The process starts from a stationary interface: h (x ,t =0 ) is given by a realization of two-sided Brownian motion constrained by h (0 ,0 )=0 . We find a singularity of the large deviation function of H at a critical value H =Hc . The singularity has the character of a second-order phase transition. It reflects spontaneous breaking of the reflection symmetry x ↔-x of optimal paths h (x ,t ) predicted by the weak-noise theory of the KPZ equation. At |H |≫| Hc| the corresponding tail of P (H ) scales as -lnP ˜|H| 3 /2/t1 /2 and agrees, at any t >0 , with the proper tail of the Baik-Rains distribution, previously observed only at long times. The other tail of P scales as -lnP ˜|H| 5 /2/t1 /2 and coincides with the corresponding tail for the sharp-wedge initial condition.
Large Deviation Function for the Number of Eigenvalues of Sparse Random Graphs Inside an Interval
NASA Astrophysics Data System (ADS)
Metz, Fernando L.; Pérez Castillo, Isaac
2016-09-01
We present a general method to obtain the exact rate function Ψ[a ,b ](k ) controlling the large deviation probability Prob[IN[a ,b ]=k N ]≍e-N Ψ[a ,b ](k ) that an N ×N sparse random matrix has IN[a ,b ]=k N eigenvalues inside the interval [a ,b ]. The method is applied to study the eigenvalue statistics in two distinct examples: (i) the shifted index number of eigenvalues for an ensemble of Erdös-Rényi graphs and (ii) the number of eigenvalues within a bounded region of the spectrum for the Anderson model on regular random graphs. A salient feature of the rate function in both cases is that, unlike rotationally invariant random matrices, it is asymmetric with respect to its minimum. The asymmetric character depends on the disorder in a way that is compatible with the distinct eigenvalue statistics corresponding to localized and delocalized eigenstates. The results also show that the level compressibility κ2/κ1 for the Anderson model on a regular graph satisfies 0 <κ2/κ1<1 in the bulk regime, in contrast with the behavior found in Gaussian random matrices. Our theoretical findings are thoroughly compared to numerical diagonalization in both cases, showing a reasonable good agreement.
NASA Astrophysics Data System (ADS)
Massah, Mozhdeh; Kantz, Holger
2016-04-01
As we have one and only one earth and no replicas, climate characteristics are usually computed as time averages from a single time series. For understanding climate variability, it is essential to understand how close a single time average will typically be to an ensemble average. To answer this question, we study large deviation probabilities (LDP) of stochastic processes and characterize them by their dependence on the time window. In contrast to iid variables for which there exists an analytical expression for the rate function, the correlated variables such as auto-regressive (short memory) and auto-regressive fractionally integrated moving average (long memory) processes, have not an analytical LDP. We study LDP for these processes, in order to see how correlation affects this probability in comparison to iid data. Although short range correlations lead to a simple correction of sample size, long range correlations lead to a sub-exponential decay of LDP and hence to a very slow convergence of time averages. This effect is demonstrated for a 120 year long time series of daily temperature anomalies measured in Potsdam (Germany).
The large deviations of the whitening process in random constraint satisfaction problems
NASA Astrophysics Data System (ADS)
Braunstein, Alfredo; Dall'Asta, Luca; Semerjian, Guilhem; Zdeborová, Lenka
2016-05-01
Random constraint satisfaction problems undergo several phase transitions as the ratio between the number of constraints and the number of variables is varied. When this ratio exceeds the satisfiability threshold no more solutions exist; the satisfiable phase, for less constrained problems, is itself divided in an unclustered regime and a clustered one. In the latter solutions are grouped in clusters of nearby solutions separated in configuration space from solutions of other clusters. In addition the rigidity transition signals the appearance of so-called frozen variables in typical solutions: beyond this threshold most solutions belong to clusters with an extensive number of variables taking the same values in all solutions of the cluster. In this paper we refine the description of this phenomenon by estimating the location of the freezing transition, corresponding to the disappearance of all unfrozen solutions (not only typical ones). We also unveil phase transitions for the existence and uniqueness of locked solutions, in which all variables are frozen. From a technical point of view we characterize atypical solutions with a number of frozen variables different from the typical value via a large deviation study of the dynamics of a stripping process (whitening) that unveils the frozen variables of a solution, building upon recent works on atypical trajectories of the bootstrap percolation dynamics. Our results also bear some relevance from an algorithmic perspective, previous numerical studies having shown that heuristic algorithms of various kinds usually output unfrozen solutions.
Simulation of heat waves in climate models using large deviation algorithms
NASA Astrophysics Data System (ADS)
Ragone, Francesco; Bouchet, Freddy; Wouters, Jeroen
2016-04-01
One of the goals of climate science is to characterize the statistics of extreme, potentially dangerous events (e.g. exceptionally intense precipitations, wind gusts, heat waves) in the present and future climate. The study of extremes is however hindered by both a lack of past observational data for events with a return time larger than decades or centuries, and by the large computational cost required to perform a proper sampling of extreme statistics with state of the art climate models. The study of the dynamics leading to extreme events is especially difficult as it requires hundreds or thousands of realizations of the dynamical paths leading to similar extremes. We will discuss here a new numerical algorithm, based on large deviation theory, that allows to efficiently sample very rare events in complex climate models. A large ensemble of realizations are run in parallel, and selection and cloning procedures are applied in order to oversample the trajectories leading to the extremes of interest. The statistics and characteristic dynamics of the extremes can then be computed on a much larger sample of events. This kind of importance sampling method belongs to a class of genetic algorithms that have been successfully applied in other scientific fields (statistical mechanics, complex biomolecular dynamics), allowing to decrease by orders of magnitude the numerical cost required to sample extremes with respect to standard direct numerical sampling. We study the applicability of this method to the computation of the statistics of European surface temperatures with the Planet Simulator (Plasim), an intermediate complexity general circulation model of the atmosphere. We demonstrate the efficiency of the method by comparing its performances against standard approaches. Dynamical paths leading to heat waves are studied, enlightening the relation of Plasim heat waves with blocking events, and the dynamics leading to these events. We then discuss the feasibility of this
Mechanical principles of large mirror supports
NASA Astrophysics Data System (ADS)
Kärcher, Hans J.; Eisenträger, Peter; Süss, Martin
2010-07-01
Large thin meniscus mirrors use force-controlled shape actuators to obtain the required optical performance. The shape actuators can be interpreted as an advancement of classical mirror supports as whiffle trees or iso-static levers, which worked purely mechanical. The paper develops, after a short historical overview, the theoretical background of mirror mechanics. Different combinations of force-controlled shape actuators with mechanical, hydraulic or pneumatic whiffle trees or iso-static levers are analyzed in regard of their impact on optical performance, dynamic and control behavior. The investigations were the basis for the choice of the shape actuator system for the E-ELT M2, executed by MT Mechatronics under an ESO contract in 2008-09.
Unification of Small and Large Time Scales for Biological Evolution: Deviations from Power Law
NASA Astrophysics Data System (ADS)
Chowdhury, Debashish; Stauffer, Dietrich; Kunwar, Ambarish
2003-02-01
We develop a unified model that describes both “micro” and “macro” evolutions within a single theoretical framework. The ecosystem is described as a dynamic network; the population dynamics at each node of this network describes the “microevolution” over ecological time scales (i.e., birth, ageing, and natural death of individual organisms), while the appearance of new nodes, the slow changes of the links, and the disappearance of existing nodes accounts for the “macroevolution” over geological time scales (i.e., the origination, evolution, and extinction of species). In contrast to several earlier claims in the literature, we observe strong deviations from power law in the regime of long lifetimes.
NASA Astrophysics Data System (ADS)
Itami, Masato; Sasa, Shin-ichi
2015-11-01
We study the friction coefficient of a macroscopic sphere in a viscous fluid at low Reynolds number. First, Kirkwood's formula for the friction coefficient is reviewed on the basis of the Hamiltonian description of particle systems. According to this formula, the friction coefficient is expressed in terms of the stress correlation on the surface of the macroscopic sphere. Then, with the aid of large deviation theory, we relate the surface stress correlation to the stress correlation in the bulk of the fluid, where the latter is characterized by the viscosity in the Green-Kubo formula. By combining Kirkwood's formula and the Green-Kubo formula in large deviation theory, we derive Stokes' law without explicitly employing the hydrodynamic equations.
Extending the Principles of Intensive Writing to Large Macroeconomics Classes
ERIC Educational Resources Information Center
Docherty, Peter; Tse, Harry; Forman, Ross; McKenzie, Jo
2010-01-01
The authors report on the design and implementation of a pilot program to extend the principles of intensive writing outlined by W. Lee Hansen (1998), Murray S. Simpson and Shireen E. Carroll (1999) and David Carless (2006) to large macroeconomics classes. The key aspect of this program was its collaborative nature, with staff from two specialist…
Peletier, Mark A.; Redig, Frank; Vafayi, Kiamars
2014-09-01
We consider three one-dimensional continuous-time Markov processes on a lattice, each of which models the conduction of heat: the family of Brownian Energy Processes with parameter m (BEP(m)), a Generalized Brownian Energy Process, and the Kipnis-Marchioro-Presutti (KMP) process. The hydrodynamic limit of each of these three processes is a parabolic equation, the linear heat equation in the case of the BEP(m) and the KMP, and a nonlinear heat equation for the Generalized Brownian Energy Process with parameter a (GBEP(a)). We prove the hydrodynamic limit rigorously for the BEP(m), and give a formal derivation for the GBEP(a). We then formally derive the pathwise large-deviation rate functional for the empirical measure of the three processes. These rate functionals imply gradient-flow structures for the limiting linear and nonlinear heat equations. We contrast these gradient-flow structures with those for processes describing the diffusion of mass, most importantly the class of Wasserstein gradient-flow systems. The linear and nonlinear heat-equation gradient-flow structures are each driven by entropy terms of the form -log ρ; they involve dissipation or mobility terms of order ρ² for the linear heat equation, and a nonlinear function of ρ for the nonlinear heat equation.
... only when he or she also has a "cold" (an upper respiratory tract infection). In these individuals, ... problems related to the deviated septum. Once the "cold" resolves, and the nasal inflammation subsides, symptoms of ...
Hurtado, Pablo I; Garrido, Pedro L
2010-04-01
Most systems, when pushed out of equilibrium, respond by building up currents of locally conserved observables. Understanding how microscopic dynamics determines the averages and fluctuations of these currents is one of the main open problems in nonequilibrium statistical physics. The additivity principle is a theoretical proposal that allows to compute the current distribution in many one-dimensional nonequilibrium systems. Using simulations, we validate this conjecture in a simple and general model of energy transport, both in the presence of a temperature gradient and in canonical equilibrium. In particular, we show that the current distribution displays a Gaussian regime for small current fluctuations, as prescribed by the central limit theorem, and non-Gaussian (exponential) tails for large current deviations, obeying in all cases the Gallavotti-Cohen fluctuation theorem. In order to facilitate a given current fluctuation, the system adopts a well-defined temperature profile different from that of the steady state and in accordance with the additivity hypothesis predictions. System statistics during a large current fluctuation is independent of the sign of the current, which implies that the optimal profile (as well as higher-order profiles and spatial correlations) are invariant upon current inversion. We also demonstrate that finite-time joint fluctuations of the current and the profile are well described by the additivity functional. These results suggest the additivity hypothesis as a general and powerful tool to compute current distributions in many nonequilibrium systems.
NASA Astrophysics Data System (ADS)
Fatalov, V. R.
2013-12-01
We prove results on exact asymptotics as T\\to\\infty for the means \\mathsf{E}_{a,c}\\exp\\bigl\\{-\\int_0^T g(\\mathbf{w}(t))\\,dt\\bigr\\} and probabilities \\mathsf{P}_{a,c}\\bigl\\{\\frac1T\\int_0^Tg(\\mathbf{w}(t))\\,dt\\lt d\\bigr\\}, where \\mathbf{w}(t)=(w_1(t),\\dots,w_n(t)), t\\ge 0, is an n-dimensional Wiener process, g(x) is a positive continuous function (potential) satisfying certain conditions, d\\gt 0, and a,c\\in{R}^n are prescribed vectors. The results are obtained by a new method developed in this paper, the Laplace method for the occupation time of a multi-dimensional Wiener process. We consider examples of monomial and radial potentials and prove results on exact asymptotics of small deviations for the probabilities \\mathsf{P}_0\\bigl\\{\\int_0^1\\sum_{j=1}^n\\vert w_j(t)\\vert^p\\,dt\\lt\\varepsilon^p\\bigr\\} as \\varepsilon\\to 0 with a fixed p\\gt 0.
Large impurity effects in rubrene crystals: First-principles calculations
Tsetseris, L.; Pantelides, Sokrates T.
2008-01-01
Carrier mobilities of rubrene films are among the highest values reported for any organic semiconductor. Here, we probe with first-principles calculations the sensitivity of rubrene crystals on impurities. We find that isolated oxygen impurities create distinct peaks in the electronic density of states consistent with observations of defect levels in rubrene and that increased O content changes the position and shape of rubrene energy bands significantly. We also establish a dual role of hydrogen as individual H species and H impurity pairs create and annihilate deep carrier traps, respectively. The results are relevant to the performance and reliability of rubrene-based devices.
Dupuis, Paul
2014-03-14
This proposal is concerned with applications of Monte Carlo to problems in physics and chemistry where rare events degrade the performance of standard Monte Carlo. One class of problems is concerned with computation of various aspects of the equilibrium behavior of some Markov process via time averages. The problem to be overcome is that rare events interfere with the efficient sampling of all relevant parts of phase space. A second class concerns sampling transitions between two or more stable attractors. Here, rare events do not interfere with the sampling of all relevant parts of phase space, but make Monte Carlo inefficient because of the very large number of samples required to obtain variance comparable to the quantity estimated. The project uses large deviation methods for the mathematical analyses of various Monte Carlo techniques, and in particular for algorithmic analysis and design. This is done in the context of relevant application areas, mainly from chemistry and biology.
NASA Astrophysics Data System (ADS)
Rosi, G. A.; la Bastide, B.; Gaebler, J.; Kinzel, M.; Rival, D. E.
2014-12-01
The following study proposes a two-dimensional large-scale particle tracking velocimetry (LS-PTV) system to characterize coherent wind structures. Seven minutes of LS-PTV data is collected via an apparatus that seeds fog-filled soap bubbles into the wind at a height of 6m from the ground. The LS-PTV data is compared to 20 minutes of data collected concurrently from a wind mast at the same site. The LS-PTV system recorded a mean streamwise velocity of 1.35m/s with a standard deviation of 0.23m/s at a mean height of 2.50m with a standard deviation of 0.7m, which agrees well with the velocity profile measured by the wind mast. Furthermore, the Reynolds stresses measured by the LS-PTV system are found to compare to those measured by the wind mast and by Klebanoff [1] for a canonical turbulent boundary layer. The current study assumes that the centre-of-curvature trajectories of the particle pathlines are representative of the trajectories followed by the spanwise vortices. As a proof-of-principle study, this work has been successful in accurately describing the vortex distribution very near to the ground. However, the trajectories followed by the centres-of- curvat.ure belonging to pathlines concurrently passing through the field-of-view were sporadic and uncorrelated.
Coarse Grained Approach to First Principles Modeling of Radiation Cascade in Large Fe Supercells
NASA Astrophysics Data System (ADS)
Odbadrakh, Kh; Nicholson, D. M.; Rusanu, A.; Samolyuk, G. D.; Stoller, R. E.; Zhang, X.-G.; Stocks, G. M.
2012-12-01
Classical Molecular Dynamics (MD) simulations characterizing dislocations and radiation damage typically treat 105-107 atoms. First principles techniques employed to understand systems at an atomistic level are not practical for such large systems consisting of millions of atoms. We present an efficient coarse grained (CG) approach to calculate local electronic and magnetic properties of large MD-generated structures from the first principles. Local atomic magnetic moments in crystalline Fe are perturbed by the presence of radiation generated vacancies and interstitials. The effects are most pronounced near the defect cores and decay slowly as the strain field of the defects decrease with distance. We develop the CG technique based on the Locally Self-consistent Multiple Scattering (LSMS) method that exploits the near-sightedness of the electron Green function. The atomic positions were determined by MD with an embedded atom force field. The local moments in the neighborhood of the defect cores are calculated with first-principles based on full local structure information. Atoms in the rest of the system are modeled by representative atoms with approximated properties. The calculations result in local moments near the defect centers with first-principles accuracy, while capturing coarse-grained details of local moments at greater length scales. This CG approach makes these large scale structures amenable to first principles study.
Implementing the "Marketing You" Project in Large Sections of Principles of Marketing
ERIC Educational Resources Information Center
Smith, Karen H.
2004-01-01
There is mounting pressure on business education to increase experiential learning at the same time that budget constraints are forcing universities to increase class size. This article explains the design and implementation of the "Marketing You" project in two large sections of Principles of Marketing to bring experiential learning into the…
Dissociated Vertical Deviation
... Eye Terms Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Dissociated Vertical Deviation En Español Read in Chinese What is Dissociated Vertical Deviation (DVD)? DVD is ...
Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; Huang, Patrick; Lightstone, Felice C.
2015-10-22
Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.
Fattebert, Jean-Luc; Lau, Edmond Y; Bennion, Brian J; Huang, Patrick; Lightstone, Felice C
2015-12-01
Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale first-principles molecular dynamics simulations and applied them to the study of the enzymatic reaction catalyzed by acetylcholinesterase. We carried out density functional theory calculations for a quantum-mechanical (QM) subsystem consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM subsystem is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite-temperature sampling by first-principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Our calculations show two energy barriers along the reaction coordinate for the enzyme-catalyzed acylation of acetylcholine. The second barrier (8.5 kcal/mol) is rate-limiting for the acylation reaction and in good agreement with experiment. PMID:26642985
Fattebert, Jean-Luc; Lau, Edmond Y.; Bennion, Brian J.; Huang, Patrick; Lightstone, Felice C.
2015-10-22
Enzymes are complicated solvated systems that typically require many atoms to simulate their function with any degree of accuracy. We have recently developed numerical techniques for large scale First-Principles molecular dynamics simulations and applied them to study the enzymatic reaction catalyzed by acetylcholinesterase. We carried out Density functional theory calculations for a quantum mechanical (QM) sub- system consisting of 612 atoms with an O(N) complexity finite-difference approach. The QM sub-system is embedded inside an external potential field representing the electrostatic effect due to the environment. We obtained finite temperature sampling by First-Principles molecular dynamics for the acylation reaction of acetylcholinemore » catalyzed by acetylcholinesterase. Our calculations shows two energies barriers along the reaction coordinate for the enzyme catalyzed acylation of acetylcholine. In conclusion, the second barrier (8.5 kcal/mole) is rate-limiting for the acylation reaction and in good agreement with experiment.« less
NASA Technical Reports Server (NTRS)
Smith, Terence R.; Menon, Sudhakar; Star, Jeffrey L.; Estes, John E.
1987-01-01
This paper provides a brief survey of the history, structure and functions of 'traditional' geographic information systems (GIS), and then suggests a set of requirements that large-scale GIS should satisfy, together with a set of principles for their satisfaction. These principles, which include the systematic application of techniques from several subfields of computer science to the design and implementation of GIS and the integration of techniques from computer vision and image processing into standard GIS technology, are discussed in some detail. In particular, the paper provides a detailed discussion of questions relating to appropriate data models, data structures and computational procedures for the efficient storage, retrieval and analysis of spatially-indexed data.
Practical algorithms to facilitate large-scale first-principles molecular dynamics
NASA Astrophysics Data System (ADS)
Gygi, François; Duchemin, Ivan; Donadio, Davide; Galli, Giulia
2009-07-01
Running First-Principles Molecular Dynamics (FPMD) simulations on large parallel platforms presents a number of practical challenges related to the large size of the datasets generated during simulations and to the lack of flexibility of parallel FPMD codes for the implementation of new algorithms. In this paper, we present two approaches implemented in the Qbox code, that alleviate these problems and facilitate large-scale FPMD simulations. We first describe a parallel I/O strategy based on MPI-IO that fully exploits the performance of parallel file systems. We also describe the implementation of a client-server interface that enables coupled quantum-classical computations in which the quantum simulation run by Qbox is "driven" by another application. This feature can be used to couple FPMD simulations with other simulation methods such as e.g. Path Integral Monte Carlo, thermodynamic integration or replica exchange dynamics.
Integration of human factors principles in LARG organizations--a conceptual model.
Figueira, Sara; Machado, V Cruz; Nunes, Isabel L
2012-01-01
Nowadays many companies are undergoing organizational transformations in order to meet the changing market demands. Thus, in order to become more competitive, supply chains (SC) are adopting new management paradigms to improve SC performance: lean, agile, resilient and green (LARG paradigms). The implementation of new production paradigms demands particular care with the issues related with Human Factors to avoid health and safety problems to workers and losses to companies. Thus, the successful introduction of these new production paradigms depends among others on a Human Factors oriented approach. This work presents a conceptual framework that allows integrating ergonomic and safety design principles during the different implementation phases of lean, agile, resilient and green practices.
Thermal Conductivity and Large Isotope Effect in GaN from First Principles
Lindsay, L.; Broido, D. A.; Reinecke, T. L.
2012-08-28
We present atomistic first principles results for the lattice thermal conductivity of GaN and compare them to those for GaP, GaAs, and GaSb. In GaN we find a large increase to the thermal conductivity with isotopic enrichment, ~65% at room temperature. We show that both the high thermal conductivity and its enhancement with isotopic enrichment in GaN arise from the weak coupling of heat-carrying acoustic phonons with optic phonons. This weak scattering results from stiff atomic bonds and the large Ga to N mass ratio, which give phonons high frequencies and also a pronounced energy gap between acoustic and optic phonons compared to other materials. Rigorous understanding of these features in GaN gives important insights into the interplay between intrinsic phonon-phonon scattering and isotopic scattering in a range of materials.
The Force-From-Lipid (FFL) principle of mechanosensitivity, at large and in elements
Teng, Jinfeng; Loukin, Stephen; Anishkin, Andriy; Kung, Ching
2014-01-01
Focus on touch and hearing distracts attention from numerous subconscious force sensors such as the vital control of blood pressure, systemic osmolarity, etc. and sensors in non-animals. Multifarious manifestations should not obscure invariant and fundamental physico-chemical principles. We advocate that force-from-lipid (FFL) is one such principle. It is based on the fact that the self-assembled bilayer necessitates inherent forces that are large, and anisotropic, even at life’s origin. Functional response of membrane proteins is governed by bilayer-force changes. Added stress can redirect these forces, leading to geometric changes of embedded proteins such as ion channels. The FFL principle was first demonstrated when purified bacterial MscL remained mechanosensitive (MS) after reconstituting into bilayers. This key experiment has recently been unequivocally replicated with two vertebrate MS K2p channels. Even the canonical Kv and the Drosophila TRPCs have now been shown to be MS in biophysical and in physiological contexts, supporting the universality of the FFL paradigm. We also review the deterministic role of mechanical force during stem-cell differentiation as well as the cell-cell and cell-matrix tethers that provide force communications. In both the ear hair cell and the worm’s touch neuron, deleting the cadherin or microtubule tethers reduces but does not eliminate MS-channel activities. We found no evidence to distinguish whether these tethers directly pulls on the channel protein or a surrounding lipid platform. Regardless of the implementation, pulling tether tenses up the bilayer. Membrane tenting is directly visible at the apexes of the stereocilia. PMID:24888690
On the performance of maximum-principle enforcing methods applied to large-scale subsurface problems
NASA Astrophysics Data System (ADS)
Karra, S.; Chang, J.; Nakshatrala, K.
2014-12-01
It is well known that numerical formulations (either finite element, finite volume or finite difference) do not meet maximum principles and the non-negative constraint for anisotropic diffusion equations. But these mathematical properties and physical constraints are important for predictive simulations in subsurface modeling. Recently, optimization-based methodologies have been proposed for diffusion-type equations that respect maximum principles and meet the non-negative constraint on general computational grids. Till date these methodologies have been tested only on small-scale academic problems with few thousands of degrees-of-freedom. But for practical problems in subsurface modeling, the degrees-of-freedom easily run into millions and sometimes into billions. The purpose of this research is to systematically study the performance of the non-negative methodologies for large-scale problems and in a parallel setting. We shall use PETSc for parallel environment, and TAO for parallel optimization solvers. Numerical simulations on real sites using our methodologies will be presented.
Creminelli, Paolo; Gleyzes, Jérôme; Vernizzi, Filippo; Hui, Lam; Simonović, Marko E-mail: jerome.gleyzes@cea.fr E-mail: msimonov@sissa.it
2014-06-01
The recently derived consistency relations for Large Scale Structure do not hold if the Equivalence Principle (EP) is violated. We show it explicitly in a toy model with two fluids, one of which is coupled to a fifth force. We explore the constraints that galaxy surveys can set on EP violation looking at the squeezed limit of the 3-point function involving two populations of objects. We find that one can explore EP violations of order 10{sup −3}÷10{sup −4} on cosmological scales. Chameleon models are already very constrained by the requirement of screening within the Solar System and only a very tiny region of the parameter space can be explored with this method. We show that no violation of the consistency relations is expected in Galileon models.
Jump rates for surface diffusion of large molecules from first principles
Shea, Patrick Kreuzer, Hans Jürgen
2015-04-21
We apply a recently developed stochastic model for the surface diffusion of large molecules to calculate jump rates for 9,10-dithioanthracene on a Cu(111) surface. The necessary input parameters for the stochastic model are calculated from first principles using density functional theory (DFT). We find that the inclusion of van der Waals corrections to the DFT energies is critical to obtain good agreement with experimental results for the adsorption geometry and energy barrier for diffusion. The predictions for jump rates in our model are in excellent agreement with measured values and show a marked improvement over transition state theory (TST). We find that the jump rate prefactor is reduced by an order of magnitude from the TST estimate due to frictional damping resulting from energy exchange with surface phonons, as well as a rotational mode of the diffusing molecule.
A method of orbital analysis for large-scale first-principles simulations
Ohwaki, Tsukuru; Otani, Minoru; Ozaki, Taisuke
2014-06-28
An efficient method of calculating the natural bond orbitals (NBOs) based on a truncation of the entire density matrix of a whole system is presented for large-scale density functional theory calculations. The method recovers an orbital picture for O(N) electronic structure methods which directly evaluate the density matrix without using Kohn-Sham orbitals, thus enabling quantitative analysis of chemical reactions in large-scale systems in the language of localized Lewis-type chemical bonds. With the density matrix calculated by either an exact diagonalization or O(N) method, the computational cost is O(1) for the calculation of NBOs associated with a local region where a chemical reaction takes place. As an illustration of the method, we demonstrate how an electronic structure in a local region of interest can be analyzed by NBOs in a large-scale first-principles molecular dynamics simulation for a liquid electrolyte bulk model (propylene carbonate + LiBF{sub 4})
NASA Astrophysics Data System (ADS)
Ravindran, P.; Kjekshus, A.; Fjellvåg, H.; James, P.; Nordström, L.; Johansson, B.; Eriksson, O.
2001-04-01
The computational framework of this study is based on the local-spin-density approximation with first-principles full-potential linear muffin-tin orbital calculations including orbital polarization (OP) correction. We have studied the magnetic anisotropy for a series of bilayer CuAu(I)-type materials such as FeX, MnX (X=Ni,Pd,Pt), CoPt, NiPt, MnHg, and MnRh in a ferromagnetic state using experimental structural parameters to understand the microscopic origin of magnetic-anisotropy energy (MAE) in magnetic multilayers. Except for MnRh and MnHg, all these phases show perpendicular magnetization. We have analyzed our results in terms of angular momentum-, spin- and site-projected density of states, magnetic-angular-momentum-projected density of states, orbital-moment density of states, and total density of states. The orbital-moment number of states and the orbital-moment anisotropy for FeX (X=Ni,Pd,Pt) are calculated as a function of band filling to study its effect on MAE. The total and site-projected spin and orbital moments for all these systems are calculated with and without OP when the magnetization is along or perpendicular to the plane. The results are compared with available experimental as well as theoretical results. Our calculations show that OP always enhances the orbital moment in these phases and brings them closer to experimental values. The changes in MAE are analyzed in terms of exchange splitting, spin-orbit splitting, and tetragonal distortion/crystal-field splitting. The calculated MAE is found to be in good agreement with experimental values when the OP correction is included. Some of the materials considered here show large magnetic anisotropy of the order of meV. In particular we found that MnPt will have a very large MAE if it could be stabilized in a ferromagnetic configuration. Our analysis indicates that apart from large spin-orbit interaction and exchange interaction from at least one of the constituents, a large crystal-field splitting
Principles for selecting earthquake motions in engineering design of large dams
Krinitzsky, E.L.; Marcuson, William F.
1983-01-01
a site may be obtained from several methods that involve magnitude of earthquake, distance from source, and corresponding motions; or, alternately, peak motions may be assigned from other correlations based on earthquake intensity. Various interpretations exist to account for duration, recurrence, effects of site conditions, etc. Comparison of the various interpretations can be very useful. Probabilities can be assigned; however, they can present very serious problems unless appropriate care is taken when data are extrapolated beyond their data base. In making deterministic judgments, probabilistic data can provide useful guidance in estimating the uncertainties of the decision. The selection of a design ground motion for large dams is based in the end on subjective judgments which should depend, to an important extent, on the consequences of failure. Usually, use of a design value of ground motion representing a mean plus one standard deviation of possible variation in the mean of the data puts one in a conservative position. If failure presents no hazard to life, lower values of design ground motion may be justified, providing there are cost benefits and the risk is acceptable to the owner. Where a large hazard to life exists (i.e., a dam above an urbanized area) one may wish to use values of design ground motion that approximate the very worst case. The selection of a design ground motion must be appropriate for its particular set of circumstances.
Guelpa, Valérian; Laurent, Guillaume J; Sandoz, Patrick; Zea, July Galeano; Clévy, Cédric
2014-01-01
This paper presents a visual measurement method able to sense 1D rigid body displacements with very high resolutions, large ranges and high processing rates. Sub-pixelic resolution is obtained thanks to a structured pattern placed on the target. The pattern is made of twin periodic grids with slightly different periods. The periodic frames are suited for Fourier-like phase calculations-leading to high resolution-while the period difference allows the removal of phase ambiguity and thus a high range-to-resolution ratio. The paper presents the measurement principle as well as the processing algorithms (source files are provided as supplementary materials). The theoretical and experimental performances are also discussed. The processing time is around 3 µs for a line of 780 pixels, which means that the measurement rate is mostly limited by the image acquisition frame rate. A 3-σ repeatability of 5 nm is experimentally demonstrated which has to be compared with the 168 µm measurement range. PMID:24625736
Fox, Stephen J; Pittock, Chris; Fox, Thomas; Tautermann, Christofer S; Malcolm, Noj; Skylaris, Chris-Kriton
2011-12-14
Biomolecular simulations with atomistic detail are often required to describe interactions with chemical accuracy for applications such as the calculation of free energies of binding or chemical reactions in enzymes. Force fields are typically used for this task but these rely on extensive parameterisation which in cases can lead to limited accuracy and transferability, for example for ligands with unusual functional groups. These limitations can be overcome with first principles calculations with methods such as density functional theory (DFT) but at a much higher computational cost. The use of electrostatic embedding can significantly reduce this cost by representing a portion of the simulated system in terms of highly localised charge distributions. These classical charge distributions are electrostatically coupled with the quantum system and represent the effect of the environment in which the quantum system is embedded. In this paper we describe and evaluate such an embedding scheme in which the polarisation of the electronic density by the embedding charges occurs self-consistently during the calculation of the density. We have implemented this scheme in a linear-scaling DFT program as our aim is to treat with DFT entire biomolecules (such as proteins) and large portions of the solvent. We test this approach in the calculation of interaction energies of ligands with biomolecules and solvent and investigate under what conditions these can be obtained with the same level of accuracy as when the entire system is described by DFT, for a variety of neutral and charged species. PMID:22168680
Sexual "Variation" without "Deviation"
ERIC Educational Resources Information Center
Turnage, John R.; Logan, Daniel L.
1975-01-01
Non-heterosexual behavior continues to be labeled "deviant" or "maladaptive" by those propounding a learning formulation of sexual behavior. It is suggested that the term "variation" replace, in part, the term "deviation" when describing non-heterosexual behavior, especially homosexuality. (Author)
ERIC Educational Resources Information Center
Salemi, Michael K.
2009-01-01
One of the most important challenges facing college instructors of economics is helping students engage. Engagement is particularly important in a large-enrollment Principles of Economics course, where it can help students achieve a long-lived understanding of how economists use basic economic ideas to look at the world. The author reports how…
Bodnar, Richard J; Stellar, James R; Kraft, Tamar T; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo
2013-01-01
In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20-25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first
Bodnar, Richard J.; Stellar, James R.; Kraft, Tamar T.; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M.; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo
2013-01-01
In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20–25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first
Bodnar, Richard J; Stellar, James R; Kraft, Tamar T; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo
2013-01-01
In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20-25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first
Petrenko, Anton; McArthur, Dan
2010-09-01
The Precautionary Principle is a guide to coping with scientific uncertainties in the assessment and management of risks. In recent years, it has moved to the forefront of debates in policy and applied ethics, becoming a key normative tool in policy discussions in such diverse areas as medical and scientific research, health and safety regulation, environmental regulation, product development, international trade, and even judicial review. The principle has attracted critics who claim that it is fundamentally incoherent, too vague to guide policy, and makes demands that are logically and scientifically impossible. In this paper we will answer these criticisms by formulating guidelines for its application that ensure its coherence as a useful normative guide in applied and policy ethics debates. We will also provide analyses of cases that demonstrate how our version of the principle functions in practice.
Software engineering principles applied to large healthcare information systems--a case report.
Nardon, Fabiane Bizinella; de A Moura, Lincoln
2007-01-01
São Paulo is the largest city in Brazil and one of the largest cities in the world. In 2004, São Paulo City Department of Health decided to implement a Healthcare Information System to support managing healthcare services and provide an ambulatory health record. The resulting information system is one of the largest public healthcare information systems ever built, with more than 2 million lines of code. Although statistics shows that most software projects fail, and the risks for the São Paulo initiative were enormous, the information system was completed on-time and on-budget. In this paper, we discuss the software engineering principles adopted that allowed to accomplish that project's goals, hoping that sharing the experience of this project will help other healthcare information systems initiatives to succeed.
Software engineering principles applied to large healthcare information systems--a case report.
Nardon, Fabiane Bizinella; de A Moura, Lincoln
2007-01-01
São Paulo is the largest city in Brazil and one of the largest cities in the world. In 2004, São Paulo City Department of Health decided to implement a Healthcare Information System to support managing healthcare services and provide an ambulatory health record. The resulting information system is one of the largest public healthcare information systems ever built, with more than 2 million lines of code. Although statistics shows that most software projects fail, and the risks for the São Paulo initiative were enormous, the information system was completed on-time and on-budget. In this paper, we discuss the software engineering principles adopted that allowed to accomplish that project's goals, hoping that sharing the experience of this project will help other healthcare information systems initiatives to succeed. PMID:17911673
Nurbawono, Argo; Liu, Shuanglong; Zhang, Chun
2015-04-21
Time dependent density functional tight binding (TDDFTB) method is implemented with sparse matrix techniques and improved parallelization algorithms. The method is employed to calculate the optical properties of various Si nanocrystals (NCs). The calculated light absorption spectra of small Si NCs from TDDFTB were found to be comparable with many body perturbation methods utilizing planewave basis sets. For large Si NCs (more than a thousand atoms) that are beyond the reach of conventional approaches, the TDDFTB method is able to produce reasonable results that are consistent with prior experiments. We also employed the method to study the effects of surface chemistry on the optical properties of large Si NCs. We learned that the optical properties of Si NCs can be manipulated with small molecule passivations such as methyl, hydroxyl, amino, and fluorine. In general, the shifts and profiles in the absorption spectra can be tuned with suitably chosen passivants.
Large-Scale Computations Leading to a First-Principles Approach to Nuclear Structure
Ormand, W E; Navratil, P
2003-08-18
We report on large-scale applications of the ab initio, no-core shell model with the primary goal of achieving an accurate description of nuclear structure from the fundamental inter-nucleon interactions. In particular, we show that realistic two-nucleon interactions are inadequate to describe the low-lying structure of {sup 10}B, and that realistic three-nucleon interactions are essential.
Large-scale oligonucleotide synthesizers. I. Basic principles and system design.
Anderson, N G; Anderson, N L; Taylor, J; Goodman, J
1995-01-01
The central problem in scaling up oligonucleotide synthesis is to expose each element of a large bed to the same conditions obtaining in very small ones, for the same intervals of time. Our analysis suggests that scale-up is chiefly limited by fluid path length through the bed. By using annular beds in zonal centrifuge rotors of unique design, with fluid flow controlled by combining centrifugal force with differences in physical density between reagents, reagent fronts may be kept exactly perpendicular to the direction of flow in each bed element. Under these conditions, bed volume may be increased by increasing rotor length and diameter. The rotor is lined with polypropylene or Teflon, and has a thick tempered glass end window. Transparent rotary valves of a unique design allow any of 47 reagents to be selected and the direction of flow through the rotor to be controlled. A photodiode spectrophotometer provides complete absorption spectra on fluid in the rotor inlet and outlet lines every 4 s, and a large balance weighs effluent from the synthesizer continuously. The entire operation is controlled by a work station, and steps may be programmed by time, absorbance, or reagent mass. Reagents are identified by spectra, and trityls are integrated on line. A detailed time-stamped log file provides a complete record of each synthesis. PMID:7486979
A first principle particle mesh method for solution SAXS of large bio-molecular systems.
Marchi, Massimo
2016-07-28
This paper will show that the solution small angle X-ray scattering (SAXS) intensity of globular and membrane proteins can be efficiently and accurately computed from molecular dynamics trajectories using 3D fast Fourier transforms (FFTs). A suitable particle meshing interpolation, similar to the one used in smooth particle mesh Ewald for electrostatic energies and forces, was combined with a uniform solvent density FFT padding scheme to obtain a convenient SAXS spectral resolution. The CPU time scaling of the method, as a function of system size, is highly favorable and its application to large systems such as solutions of solvated membrane proteins is computationally undemanding. Differently from other approaches, all contributions from the simulation cell are included. This means that the subtraction of the buffer from the solution scattering intensity is straightforward and devoid of artifact due to ad hoc definitions of proximal and distal solvent intensity contributions. PMID:27475396
The PubChemQC project: A large chemical database from the first principle calculations
NASA Astrophysics Data System (ADS)
Maho, Nakata
2015-12-01
In this research, we have been constructing a large database of molecules by ab initio calculations. Currently, we have over 1.53 million entries of 6-31G* B3LYP optimized geometries and ten excited states by 6-31+G* TDDFT calculations. To calculate molecules, we only refer the InChI (International Chemical Identifier) representation of chemical formula by the International Union of Pure and Applied Chemistry (IUPAC), thus, no reference to experimental data. These results are open to public at http://pubchemqc.riken.jp/. The molecular data have been taken from the PubChem Project (http://pubchem.ncbi.nlm.nih.gov/) which is one of the largest in the world (approximately 63 million molecules are listed) and free (public domain) database. Our final goal is, using these data, to develop a molecular search engine or molecular expert system to find molecules which have desired properties.
A first principle particle mesh method for solution SAXS of large bio-molecular systems
NASA Astrophysics Data System (ADS)
Marchi, Massimo
2016-07-01
This paper will show that the solution small angle X-ray scattering (SAXS) intensity of globular and membrane proteins can be efficiently and accurately computed from molecular dynamics trajectories using 3D fast Fourier transforms (FFTs). A suitable particle meshing interpolation, similar to the one used in smooth particle mesh Ewald for electrostatic energies and forces, was combined with a uniform solvent density FFT padding scheme to obtain a convenient SAXS spectral resolution. The CPU time scaling of the method, as a function of system size, is highly favorable and its application to large systems such as solutions of solvated membrane proteins is computationally undemanding. Differently from other approaches, all contributions from the simulation cell are included. This means that the subtraction of the buffer from the solution scattering intensity is straightforward and devoid of artifact due to ad hoc definitions of proximal and distal solvent intensity contributions.
Shinde, Ravindra; Shukla, Alok
2014-10-14
We report the linear optical absorption spectra of aluminum clusters Aln (n = 2-5) involving valence transitions, computed using the large-scale all-electron configuration interaction (CI) methodology. Several low-lying isomers of each cluster were considered, and their geometries were optimized at the coupled-cluster singles-doubles (CCSD) level of theory. With these optimized ground-state geometries, excited states of different clusters were computed using the multi-reference singles-doubles configuration-interaction (MRSDCI) approach, which includes electron correlation effects at a sophisticated level. These CI wave functions were used to compute the transition dipole matrix elements connecting the ground and various excited states of different clusters, and thus their photoabsorption spectra. The convergence of our results with respect to the basis sets, and the size of the CI expansion, was carefully examined. Our results were found to be significantly different as compared to those obtained using time-dependent density functional theory (TDDFT) [Deshpande et al. Phys. Rev. B: Condens. Matter Mater. Phys., 2003, 68, 035428]. When compared to the available experimental data for the isomers of Al2 and Al3, our results are in very good agreement as far as important peak positions are concerned. The contribution of configurations to many body wave functions of various excited states suggests that in most cases optical excitations involved are collective, and plasmonic in nature. PMID:25162600
[Behavior therapy in sexual deviation].
Schmieschek, H
1977-12-01
The author, after discussing theoretical aspects of the development and treatment of sexual deviations, describes methods of behavior therapy which when used in combination and by experienced clinicians will yield promising results. In addition, a number of cases are reported, and these indicate some special problems associated with the therapy of sexual deviations.
NASA Astrophysics Data System (ADS)
Ono, Tomoya; Tsukamoto, Shigeru
2016-01-01
We present a fast and stable numerical technique to obtain the self-energy terms of electrodes for first-principles electron transport calculations. Although first-principles calculations based on the real-space finite-difference method are advantageous for execution on massively parallel computers, large-scale transport calculations are hampered by the computational cost and numerical instability of the computation of the self-energy terms. Using the orthogonal complement vectors of the space spanned by the generalized Bloch waves that actually contribute to transport phenomena, the computational accuracy of transport properties is significantly improved with a moderate computational cost. To demonstrate the efficiency of the present technique, the electron transport properties of a Stone-Wales (SW) defect in graphene and silicene are examined. The resonance scattering of the SW defect is observed in the conductance spectrum of silicene since the σ* state of silicene lies near the Fermi energy. In addition, we found that one conduction channel is sensitive to a defect near the Fermi energy, while the other channel is hardly affected. This characteristic behavior of the conduction channels is interpreted in terms of the bonding network between the bilattices of the honeycomb structure in the formation of the SW defect. The present technique enables us to distinguish the different behaviors of the two conduction channels in graphene and silicene owing to its excellent accuracy.
Schubert, Walter
2013-01-01
Understanding biological systems at the level of their relational (emergent) molecular properties in functional protein networks relies on imaging methods, able to spatially resolve a tissue or a cell as a giant, non-random, topologically defined collection of interacting supermolecules executing myriads of subcellular mechanisms. Here, the development and findings of parameter-unlimited functional super-resolution microscopy are described—a technology based on the fluorescence imaging cycler (IC) principle capable of co-mapping thousands of distinct biomolecular assemblies at high spatial resolution and differentiation (<40 nm distances). It is shown that the subcellular and transcellular features of such supermolecules can be described at the compositional and constitutional levels; that the spatial connection, relational stoichiometry, and topology of supermolecules generate hitherto unrecognized functional self-segmentation of biological tissues; that hierarchical features, common to thousands of simultaneously imaged supermolecules, can be identified; and how the resulting supramolecular order relates to spatial coding of cellular functionalities in biological systems. A large body of observations with IC molecular systems microscopy collected over 20 years have disclosed principles governed by a law of supramolecular segregation of cellular functionalities. This pervades phenomena, such as exceptional orderliness, functional selectivity, combinatorial and spatial periodicity, and hierarchical organization of large molecular systems, across all species investigated so far. This insight is based on the high degree of specificity, selectivity, and sensitivity of molecular recognition processes for fluorescence imaging beyond the spectral resolution limit, using probe libraries controlled by ICs. © 2013 The Authors. Journal of Molecular Recognition published by John Wiley & Sons, Ltd. PMID:24375580
Liu, Huanxiang; Papa, Ester; Gramatica, Paola
2006-11-01
A large number of environmental chemicals, known as endocrine-disrupting chemicals, are suspected of disrupting endocrine functions by mimicking or antagonizing natural hormones, and such chemicals may pose a serious threat to the health of humans and wildlife. They are thought to act through a variety of mechanisms, mainly estrogen-receptor-mediated mechanisms of toxicity. However, it is practically impossible to perform thorough toxicological tests on all potential xenoestrogens, and thus, the quantitative structure--activity relationship (QSAR) provides a promising method for the estimation of a compound's estrogenic activity. Here, QSAR models of the estrogen receptor binding affinity of a large data set of heterogeneous chemicals have been built using theoretical molecular descriptors, giving full consideration to the new OECD principles in regulation for QSAR acceptability, during model construction and assessment. An unambiguous multiple linear regression (MLR) algorithm was used to build the models, and model predictive ability was validated by both internal and external validation. The applicability domain was checked by the leverage approach to verify prediction reliability. The results obtained using several validation paths indicate that the proposed QSAR model is robust and satisfactory, and can provide a feasible and practical tool for the rapid screening of the estrogen activity of organic compounds.
Fox, Stephen J; Pittock, Chris; Tautermann, Christofer S; Fox, Thomas; Christ, Clara; Malcolm, N O J; Essex, Jonathan W; Skylaris, Chris-Kriton
2013-08-15
Schemes of increasing sophistication for obtaining free energies of binding have been developed over the years, where configurational sampling is used to include the all-important entropic contributions to the free energies. However, the quality of the results will also depend on the accuracy with which the intermolecular interactions are computed at each molecular configuration. In this context, the energy change associated with the rearrangement of electrons (electronic polarization and charge transfer) upon binding is a very important effect. Classical molecular mechanics force fields do not take this effect into account explicitly, and polarizable force fields and semiempirical quantum or hybrid quantum-classical (QM/MM) calculations are increasingly employed (at higher computational cost) to compute intermolecular interactions in free-energy schemes. In this work, we investigate the use of large-scale quantum mechanical calculations from first-principles as a way of fully taking into account electronic effects in free-energy calculations. We employ a one-step free-energy perturbation (FEP) scheme from a molecular mechanical (MM) potential to a quantum mechanical (QM) potential as a correction to thermodynamic integration calculations within the MM potential. We use this approach to calculate relative free energies of hydration of small aromatic molecules. Our quantum calculations are performed on multiple configurations from classical molecular dynamics simulations. The quantum energy of each configuration is obtained from density functional theory calculations with a near-complete psinc basis set on over 600 atoms using the ONETEP program.
NASA Astrophysics Data System (ADS)
Guo, Peng-Jie; Yang, Huan-Cheng; Zhang, Bing-Jing; Liu, Kai; Lu, Zhong-Yi
2016-06-01
By the first-principles electronic structure calculations, we have systematically studied the electronic structures of recently discovered extremely large magnetoresistance (XMR) materials LaSb and LaBi. We find that both LaSb and LaBi are semimetals with the electron and hole carriers in balance. The calculated carrier densities on the order of 1020cm-3 are in good agreement with the experimental values, implying long mean-free time of carriers at low temperatures and thus high carrier mobilities. With a semiclassical two-band model, the charge compensation and high carrier mobilities naturally explain: (i) the XMR observed in LaSb and LaBi, (ii) the nonsaturating quadratic dependence of XMR on an external magnetic field, and (iii) the resistivity plateau in the turn-on temperature behavior at very low temperatures. The explanation of these features without resorting to the topological effect indicates that they should be the common characteristics of all electron-hole compensated semimetals.
Han, Yong; Evans, James W.
2015-10-28
Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C{sub 6}-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom in the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ∼0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. This in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001)
Han, Yong; Evans, James W.
2015-10-27
Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C6-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom inmore » the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ~0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. Furthermore, this in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001).« less
Han, Yong; Evans, James W.
2015-10-27
Large-scale first-principles density functional theory calculations are performed to investigate the adsorption and diffusion of Ru adatoms on monolayer graphene (G) supported on Ru(0001). The G sheet exhibits a periodic moiré-cell superstructure due to lattice mismatch. Within a moiré cell, there are three distinct regions: fcc, hcp, and mound, in which the C6-ring center is above a fcc site, a hcp site, and a surface Ru atom of Ru(0001), respectively. The adsorption energy of a Ru adatom is evaluated at specific sites in these distinct regions. We find the strongest binding at an adsorption site above a C atom in the fcc region, next strongest in the hcp region, then the fcc-hcp boundary (ridge) between these regions, and the weakest binding in the mound region. Behavior is similar to that observed from small-unit-cell calculations of Habenicht et al. [Top. Catal. 57, 69 (2014)], which differ from previous large-scale calculations. We determine the minimum-energy path for local diffusion near the center of the fcc region and obtain a local diffusion barrier of ~0.48 eV. We also estimate a significantly lower local diffusion barrier in the ridge region. These barriers and information on the adsorption energy variation facilitate development of a realistic model for the global potential energy surface for Ru adatoms. Furthermore, this in turn enables simulation studies elucidating diffusion-mediated directed-assembly of Ru nanoclusters during deposition of Ru on G/Ru(0001).
Standard Deviation for Small Samples
ERIC Educational Resources Information Center
Joarder, Anwar H.; Latif, Raja M.
2006-01-01
Neater representations for variance are given for small sample sizes, especially for 3 and 4. With these representations, variance can be calculated without a calculator if sample sizes are small and observations are integers, and an upper bound for the standard deviation is immediate. Accessible proofs of lower and upper bounds are presented for…
48 CFR 801.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations. 801... Individual deviations. (a) Authority to authorize individual deviations from the FAR and VAAR is delegated to... nature of the deviation. (d) The DSPE may authorize individual deviations from the FAR and VAAR when...
48 CFR 2001.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2001... Individual deviations. In individual cases, deviations from either the FAR or the NRCAR will be authorized... deviations clearly in the best interest of the Government. Individual deviations must be authorized...
Perception of aircraft Deviation Cues
NASA Technical Reports Server (NTRS)
Martin, Lynne; Azuma, Ronald; Fox, Jason; Verma, Savita; Lozito, Sandra
2005-01-01
To begin to address the need for new displays, required by a future airspace concept to support new roles that will be assigned to flight crews, a study of potentially informative display cues was undertaken. Two cues were tested on a simple plan display - aircraft trajectory and flight corridor. Of particular interest was the speed and accuracy with which participants could detect an aircraft deviating outside its flight corridor. Presence of the trajectory cue significantly reduced participant reaction time to a deviation while the flight corridor cue did not. Although non-significant, the flight corridor cue seemed to have a relationship with the accuracy of participants judgments rather than their speed. As this is the second of a series of studies, these issues will be addressed further in future studies.
48 CFR 401.404 - Class deviations.
Code of Federal Regulations, 2011 CFR
2011-10-01
... ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.404 Class deviations. Where deviations from the FAR or AGAR are considered necessary for classes of contracts, requests for authority to...
48 CFR 401.404 - Class deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.404 Class deviations. Where deviations from the FAR or AGAR are considered necessary for classes of contracts, requests for authority to...
Deviation of the statistical fluctuation in heterogeneous anomalous diffusion
NASA Astrophysics Data System (ADS)
Itto, Yuichi
2016-11-01
The exponent of anomalous diffusion of virus in cytoplasm of a living cell is experimentally known to fluctuate depending on localized areas of the cytoplasm, indicating heterogeneity of diffusion. In a recent paper (Itto, 2012), a maximum-entropy-principle approach has been developed in order to propose an Ansatz for the statistical distribution of such exponent fluctuations. Based on this approach, here the deviation of the statistical distribution of the fluctuations from the proposed one is studied from the viewpoint of Einstein's theory of fluctuations (of the thermodynamic quantities). This may present a step toward understanding the statistical property of the deviation. It is shown in a certain class of small deviations that the deviation obeys the multivariate Gaussian distribution.
48 CFR 1501.404 - Class deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Class deviations. 1501.404 Section 1501.404 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.404 Class deviations. Requests for class deviations to the FAR and the EPAAR shall...
48 CFR 401.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... AGRICULTURE ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.403 Individual deviations. In individual cases, deviations from either the FAR or the AGAR will be authorized only when essential to effect... AGAR, after coordinating with the General Counsel and the SPE. No deviations from the FAR or AGAR...
48 CFR 401.403 - Individual deviations.
Code of Federal Regulations, 2011 CFR
2011-10-01
... AGRICULTURE ACQUISITION REGULATION SYSTEM Deviations From the FAR and AGAR 401.403 Individual deviations. In individual cases, deviations from either the FAR or the AGAR will be authorized only when essential to effect... AGAR, after coordinating with the General Counsel and the SPE. No deviations from the FAR or AGAR...
48 CFR 2401.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2401... DEVELOPMENT GENERAL FEDERAL ACQUISITION REGULATION SYSTEM Deviations 2401.403 Individual deviations. In individual cases, proposed deviations from the FAR or HUDAR shall be submitted to the Senior...
48 CFR 501.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 501... Individual deviations. (a) An individual deviation affects only one contract action. (1) The Head of the Contracting Activity (HCA) must approve an individual deviation to the FAR. The authority to grant...
48 CFR 1301.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations... DEPARTMENT OF COMMERCE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 1301.403 Individual deviations. The designee authorized to approve individual deviations from the FAR is set forth in CAM 1301.70....
48 CFR 1501.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 1501.403 Section 1501.403 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL GENERAL Deviations 1501.403 Individual deviations. Requests for individual deviations from the FAR and...
48 CFR 2801.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2801... OF JUSTICE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR and JAR 2801.403 Individual deviations. Individual deviations from the FAR or the JAR shall be approved by the head of the...
48 CFR 301.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 301... ACQUISITION REGULATION SYSTEM Deviations From the FAR 301.403 Individual deviations. Contracting activities shall prepare requests for individual deviations to either the FAR or HHSAR in accordance with 301.470....
Code of Federal Regulations, 2010 CFR
2010-01-01
... proposed deviation from this part would be a deviation from 10 CFR part 600, the deviation must also be... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 602.4 Section 602.4 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL...
Assessment and classification of protocol deviations
Ghooi, Ravindra Bhaskar; Bhosale, Neelambari; Wadhwani, Reena; Divate, Pathik; Divate, Uma
2016-01-01
Introduction: Deviations from the approved trial protocol are common during clinical trials. They have been conventionally classified as deviations or violations, depending on their impact on the trial. Methods: A new method has been proposed by which deviations are classified in five grades from 1 to 5. A deviation of Grade 1 has no impact on the subjects’ well-being or on the quality of data. At the maximum, a deviation Grade 5 leads to the death of the subject. This method of classification was applied to deviations noted in the center over the last 3 years. Results: It was observed that most deviations were of Grades 1 and 2, with fewer falling in Grades 3 and 4. There were no deviations that led to the death of the subject (Grade 5). Discussion: This method of classification would help trial managers decide on the action to be taken on the occurrence of deviations, which would be based on their impact. PMID:27453830
48 CFR 501.404 - Class deviations.
Code of Federal Regulations, 2012 CFR
2012-10-01
... HCA to GSA's SPE for approval. Prior to approving a class deviation to the FAR, the SPE will consult...). (2) A class deviation to the GSAR must be forwarded by the cognizant HCA to GSA's SPE for approval. (3) When an HCA knows that a proposed class deviation will be required on a permanent basis, the...
48 CFR 501.404 - Class deviations.
Code of Federal Regulations, 2011 CFR
2011-10-01
... HCA to GSA's SPE for approval. Prior to approving a class deviation to the FAR, the SPE will consult...). (2) A class deviation to the GSAR must be forwarded by the cognizant HCA to GSA's SPE for approval. (3) When an HCA knows that a proposed class deviation will be required on a permanent basis, the...
Code of Federal Regulations, 2011 CFR
2011-01-01
... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2011-01-01 2011-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...
Code of Federal Regulations, 2010 CFR
2010-01-01
... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...
Code of Federal Regulations, 2014 CFR
2014-01-01
... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2014-01-01 2014-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...
Code of Federal Regulations, 2012 CFR
2012-01-01
... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2012-01-01 2012-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...
Code of Federal Regulations, 2013 CFR
2013-01-01
... the deviation and nuclear power reactor(s) affected; (e) A statement as to whether the deviation has... 10 Energy 4 2013-01-01 2013-01-01 false Deviations. 961.4 Section 961.4 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE...
48 CFR 1.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Individual deviations. 1.403 Section 1.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 1.403 Individual deviations....
48 CFR 601.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Individual deviations. 601.403 Section 601.403 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL DEPARTMENT OF STATE ACQUISITION REGULATIONS SYSTEM Deviations from the FAR 601.403 Individual deviations....
48 CFR 1901.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 1901.403 Section 1901.403 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL... Individual deviations. Deviations from the IAAR or the FAR in individual cases shall be authorized by...
48 CFR 3401.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Individual deviations. 3401.403 Section 3401.403 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION GENERAL ED ACQUISITION REGULATION SYSTEM Deviations 3401.403 Individual deviations. An...
48 CFR 2501.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Individual deviations. 2501.403 Section 2501.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Deviations From the FAR 2501.403 Individual deviations....
Introducing the Mean Absolute Deviation "Effect" Size
ERIC Educational Resources Information Center
Gorard, Stephen
2015-01-01
This paper revisits the use of effect sizes in the analysis of experimental and similar results, and reminds readers of the relative advantages of the mean absolute deviation as a measure of variation, as opposed to the more complex standard deviation. The mean absolute deviation is easier to use and understand, and more tolerant of extreme…
Osei-Kuffuor, Daniel; Fattebert, Jean-Luc
2014-01-01
We present the first truly scalable first-principles molecular dynamics algorithm with O(N) complexity and controllable accuracy, capable of simulating systems with finite band gaps of sizes that were previously impossible with this degree of accuracy. By avoiding global communications, we provide a practical computational scheme capable of extreme scalability. Accuracy is controlled by the mesh spacing of the finite difference discretization, the size of the localization regions in which the electronic wave functions are confined, and a cutoff beyond which the components of the overlap matrix can be omitted when computing selected elements of its inverse. We demonstrate the algorithm's excellent parallel scaling for up to 101 952 atoms on 23 328 processors, with a wall-clock time of the order of 1 min per molecular dynamics time step and numerical error on the forces of less than 7x10^{-4} Ha/Bohr.
The Standard Deviation of Launch Vehicle Environments
NASA Technical Reports Server (NTRS)
Yunis, Isam
2005-01-01
Statistical analysis is used in the development of the launch vehicle environments of acoustics, vibrations, and shock. The standard deviation of these environments is critical to accurate statistical extrema. However, often very little data exists to define the standard deviation and it is better to use a typical standard deviation than one derived from a few measurements. This paper uses Space Shuttle and expendable launch vehicle flight data to define a typical standard deviation for acoustics and vibrations. The results suggest that 3dB is a conservative and reasonable standard deviation for the source environment and the payload environment.
A Scalable O(N) Algorithm for Large-Scale Parallel First-Principles Molecular Dynamics Simulations
Osei-Kuffuor, Daniel; Fattebert, Jean-Luc
2014-01-01
Traditional algorithms for first-principles molecular dynamics (FPMD) simulations only gain a modest capability increase from current petascale computers, due to their O(N^{3}) complexity and their heavy use of global communications. To address this issue, we are developing a truly scalable O(N) complexity FPMD algorithm, based on density functional theory (DFT), which avoids global communications. The computational model uses a general nonorthogonal orbital formulation for the DFT energy functional, which requires knowledge of selected elements of the inverse of the associated overlap matrix. We present a scalable algorithm for approximately computing selected entries of the inverse of the overlap matrix, based on an approximate inverse technique, by inverting local blocks corresponding to principal submatrices of the global overlap matrix. The new FPMD algorithm exploits sparsity and uses nearest neighbor communication to provide a computational scheme capable of extreme scalability. Accuracy is controlled by the mesh spacing of the finite difference discretization, the size of the localization regions in which the electronic orbitals are confined, and a cutoff beyond which the entries of the overlap matrix can be omitted when computing selected entries of its inverse. We demonstrate the algorithm's excellent parallel scaling for up to O(100K) atoms on O(100K) processors, with a wall-clock time of O(1) minute per molecular dynamics time step.
Large Deviation Statistics of Vorticity Stretching in Isotropic Turbulence
NASA Astrophysics Data System (ADS)
Johnson, Perry; Meneveau, Charles
2015-11-01
A key feature of 3D fluid turbulence is the stretching/re-alignment of vorticity by the action of the strain-rate. It is shown using the cumulant-generating function that cumulative vorticity stretching along a Lagrangian path in isotropic turbulence behaves statistically like a sum of i.i.d. variables. The Cramer function for vorticity stretching is computed from the JHTDB isotropic DNS (Reλ = 430) and compared to those of the finite-time Lyapunov exponents (FTLE) for material deformation. As expected the mean cumulative vorticity stretching is slightly less than that of the most-stretched material line (largest FTLE), due to the vorticity's preferential alignment with the second-largest eigenvalue of strain-rate and the material line's preferential alignment with the largest eigenvalue. However, the vorticity stretching tends to be significantly larger than the second-largest FTLE, and the Cramer functions reveal that the statistics of vorticity stretching fluctuations are more similar to those of largest FTLE. A model Fokker-Planck equation is constructed by approximating the viscous destruction of vorticity with a deterministic non-linear relaxation law matching conditional statistics, while the fluctuations in vorticity stretching are modelled by stochastic noise matching the statistics encoded in the Cramer function. The model predicts a stretched-exponential tail for the vorticity magnitude PDF, with good agreement for the exponent but significant error (30-40%) in the pre-factor. Supported by NSF Graduate Fellowship (DGE-1232825) and NSF Grant CMMI-0941530.
Large deviations of Rouse polymer chain: First passage problem
NASA Astrophysics Data System (ADS)
Cao, Jing; Zhu, Jian; Wang, Zuowei; Likhtman, Alexei E.
2015-11-01
The purpose of this paper is to investigate several analytical methods of solving first passage (FP) problem for the Rouse model, a simplest model of a polymer chain. We show that this problem has to be treated as a multi-dimensional Kramers' problem, which presents rich and unexpected behavior. We first perform direct and forward-flux sampling (FFS) simulations and measure the mean first-passage time τ(z) for the free end to reach a certain distance z away from the origin. The results show that the mean FP time is getting faster if the Rouse chain is represented by more beads. Two scaling regimes of τ(z) are observed, with transition between them varying as a function of chain length. We use these simulation results to test two theoretical approaches. One is a well known asymptotic theory valid in the limit of zero temperature. We show that this limit corresponds to fully extended chain when each chain segment is stretched, which is not particularly realistic. A new theory based on the well known Freidlin-Wentzell theory is proposed, where dynamics is projected onto the minimal action path. The new theory predicts both scaling regimes correctly, but fails to get the correct numerical prefactor in the first regime. Combining our theory with the FFS simulations leads us to a simple analytical expression valid for all extensions and chain lengths. One of the applications of polymer FP problem occurs in the context of branched polymer rheology. In this paper, we consider the arm-retraction mechanism in the tube model, which maps exactly on the model we have solved. The results are compared to the Milner-McLeish theory without constraint release, which is found to overestimate FP time by a factor of 10 or more.
Large deviations of Rouse polymer chain: First passage problem.
Cao, Jing; Zhu, Jian; Wang, Zuowei; Likhtman, Alexei E
2015-11-28
The purpose of this paper is to investigate several analytical methods of solving first passage (FP) problem for the Rouse model, a simplest model of a polymer chain. We show that this problem has to be treated as a multi-dimensional Kramers' problem, which presents rich and unexpected behavior. We first perform direct and forward-flux sampling (FFS) simulations and measure the mean first-passage time τ(z) for the free end to reach a certain distance z away from the origin. The results show that the mean FP time is getting faster if the Rouse chain is represented by more beads. Two scaling regimes of τ(z) are observed, with transition between them varying as a function of chain length. We use these simulation results to test two theoretical approaches. One is a well known asymptotic theory valid in the limit of zero temperature. We show that this limit corresponds to fully extended chain when each chain segment is stretched, which is not particularly realistic. A new theory based on the well known Freidlin-Wentzell theory is proposed, where dynamics is projected onto the minimal action path. The new theory predicts both scaling regimes correctly, but fails to get the correct numerical prefactor in the first regime. Combining our theory with the FFS simulations leads us to a simple analytical expression valid for all extensions and chain lengths. One of the applications of polymer FP problem occurs in the context of branched polymer rheology. In this paper, we consider the arm-retraction mechanism in the tube model, which maps exactly on the model we have solved. The results are compared to the Milner-McLeish theory without constraint release, which is found to overestimate FP time by a factor of 10 or more. PMID:26627948
Large perpendicular magnetic anisotropy of single Co atom on MgO monolayer: A first-principles study
Shao, Bin; Shi, Wu-Jun; Feng, Min; Zuo, Xu
2015-05-07
Realizing the magnetic bit with a single atom is the ultimate goal for magnetic storage. Based on density functional theory, the magnetic anisotropy (MA) of single Co atom on MgO monolayer has been investigated. Results show that this two dimensional system possesses a large perpendicular MA, about 5.8 meV per Co atom. Besides, there exists remarkable unquenched orbital moments for different magnetization directions, which can be attributed to the reduction of coordination number in two dimensional system and is responsible for the enhanced MA. The Bloch pseudo-wavefunction and band structure of Co d-orbitals have been calculated to elucidate the origin of the perpendicular MA.
NASA Astrophysics Data System (ADS)
Norouzzadeh, Payam; Myles, Charles W.; Vashaee, Daryoosh
2013-11-01
The material design of type-VIII clathrate Si46 is presented based on first principles. The structural, electronic, elastic, vibrational, and thermodynamic properties of this hypothetical material are presented. Our results predict that type-VIII clathrate Si46 is an indirect semiconductor with a bandgap of 1.24 eV. The band structure revealed an interestingly large number of electron pockets near both conduction and valance band edges. Such a large density of states near the band edges, which is higher than that of the best thermoelectric materials discovered so far, can result in a large thermoelectric power factor (>0.004 W m-1 K-2) making it a promising candidate for thermoelectric applications. The elastic properties as well as the vibrational modes and the phonon state densities of this material were also calculated. Our calculations predict that the heat capacity at constant volume (isochoric) of this clathrate increases smoothly with temperature and approaches the Dulong-Petit value near room temperature. The electronic band structure shows a large number of valleys closely packed around the valance band edge, which is rare among the known semiconducting materials. These valleys can contribute to transport at high temperature resulting in a possibly high performance (ZT > 1.5) p-type thermoelectric material.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Deviations. 139.113 Section 139.113 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... life or property, the certificate holder may deviate from any requirement of subpart D of this part,...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviation. 105-1.110 Section 105-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation....
Code of Federal Regulations, 2012 CFR
2012-01-01
... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Deviations. 1216.318 Section 1216.318 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Procedures for Implementing the National Environmental Policy Act (NEPA) Agency Procedures § 1216.318 Deviations. From time...
Code of Federal Regulations, 2012 CFR
2012-07-01
... 34 Education 1 2012-07-01 2012-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary,...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 34 Education 1 2014-07-01 2014-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary, after consultation with the Office of...
48 CFR 2901.404 - Class deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... through the Director, DAMS. (b) Requests for deviations under paragraph (a) of this section must be... contracting actions which will be affected. (c) For a FAR class deviation the Director, DAMS will consult with... Director, DAMS as required in FAR 1.404....
48 CFR 1401.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations. 1401.403 Section 1401.403 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL DEPARTMENT OF THE INTERIOR ACQUISITION REGULATION SYSTEM Deviations from the FAR and DIAR 1401.403...
48 CFR 1201.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
...) 48 CFR 1.405(e) applies). However, see TAM 1201.403. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Individual deviations... FEDERAL ACQUISITION REGULATIONS SYSTEM 70-Deviations From the FAR and TAR 1201.403 Individual...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 34 Education 1 2010-07-01 2010-07-01 false Deviations. 74.4 Section 74.4 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 74.4 Deviations. The Secretary,...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management...
48 CFR 1901.403 - Individual deviations.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Individual deviations. 1901.403 Section 1901.403 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL THE BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR...
48 CFR 1901.404 - Class deviations.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Class deviations. 1901.404 Section 1901.404 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL THE BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR 1901.404 Class...
48 CFR 1901.403 - Individual deviations.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Individual deviations. 1901.403 Section 1901.403 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL THE BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR...
48 CFR 1901.404 - Class deviations.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Class deviations. 1901.404 Section 1901.404 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS GENERAL THE BROADCASTING BOARD OF GOVERNORS ACQUISITION REGULATION SYSTEM Deviations From the FAR 1901.404 Class...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Deviations. 800.204 Section 800.204 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE Loans § 800.204 Deviations. (a) To the extent consistent with the Act, relevant...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 4 2013-01-01 2013-01-01 false Deviations. 800.204 Section 800.204 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE Loans § 800.204 Deviations. (a) To the extent consistent with the Act, relevant...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 10 Energy 4 2014-01-01 2014-01-01 false Deviations. 800.204 Section 800.204 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE Loans § 800.204 Deviations. (a) To the extent consistent with the Act, relevant...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 4 2012-01-01 2012-01-01 false Deviations. 800.204 Section 800.204 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE Loans § 800.204 Deviations. (a) To the extent consistent with the Act, relevant...
Exploring Students' Conceptions of the Standard Deviation
ERIC Educational Resources Information Center
delMas, Robert; Liu, Yan
2005-01-01
This study investigated introductory statistics students' conceptual understanding of the standard deviation. A computer environment was designed to promote students' ability to coordinate characteristics of variation of values about the mean with the size of the standard deviation as a measure of that variation. Twelve students participated in an…
Code of Federal Regulations, 2011 CFR
2011-07-01
... deviations. Individual deviations affecting only one award may be approved by DoD Components in accordance with procedures stated in 32 CFR 21.335(a) and 21.340. (b) Small awards. DoD Components may apply less..., the Director, Defense Research and Engineering, or his or her designee, may grant exceptions from...
Code of Federal Regulations, 2010 CFR
2010-07-01
... deviations. Individual deviations affecting only one award may be approved by DoD Components in accordance with procedures stated in 32 CFR 21.335(a) and 21.340. (b) Small awards. DoD Components may apply less..., the Director, Defense Research and Engineering, or his or her designee, may grant exceptions from...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 4 2012-01-01 2012-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 10 Energy 4 2014-01-01 2014-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 4 2013-01-01 2013-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Deviations. 609.18 Section 609.18 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS LOAN GUARANTEES FOR PROJECTS THAT EMPLOY INNOVATIVE TECHNOLOGIES § 609.18 Deviations. To the extent that such requirements are not specified by the Act or...
Code of Federal Regulations, 2013 CFR
2013-07-01
... (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation. (a..., deviations; i.e., the use of any policy or procedure in any manner that is inconsistent with a policy or... have been requested from and approved by the Administrator of General Services or his...
Code of Federal Regulations, 2011 CFR
2011-01-01
... (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation. (a..., deviations; i.e., the use of any policy or procedure in any manner that is inconsistent with a policy or... have been requested from and approved by the Administrator of General Services or his...
Scaling Deviations for Neutrino Reactions in Aysmptotically Free Field Theories
DOE R&D Accomplishments Database
Wilczek, F. A.; Zee, A.; Treiman, S. B.
1974-11-01
Several aspects of deep inelastic neutrino scattering are discussed in the framework of asymptotically free field theories. We first consider the growth behavior of the total cross sections at large energies. Because of the deviations from strict scaling which are characteristic of such theories the growth need not be linear. However, upper and lower bounds are established which rather closely bracket a linear growth. We next consider in more detail the expected pattern of scaling deviation for the structure functions and, correspondingly, for the differential cross sections. The analysis here is based on certain speculative assumptions. The focus is on qualitative effects of scaling breakdown as they may show up in the X and y distributions. The last section of the paper deals with deviations from the Callan-Gross relation.
48 CFR 201.403 - Individual deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
.... 2341(2)), or with United Nations or NATO organizations; and (ii) Such governments or organizations will...). (2) Contracting officers outside the United States may deviate from prescribed nonstatutory FAR...
48 CFR 201.404 - Class deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Air Force, and the Directors of the Defense Commissary Agency, the Defense Contract Management Agency, and the Defense Logistics Agency, may approve any class deviation, other than those described in...
Attacks exploiting deviation of mean photon number in quantum key distribution and coin tossing
NASA Astrophysics Data System (ADS)
Sajeed, Shihan; Radchenko, Igor; Kaiser, Sarah; Bourgoin, Jean-Philippe; Pappa, Anna; Monat, Laurent; Legré, Matthieu; Makarov, Vadim
2015-03-01
The security of quantum communication using a weak coherent source requires an accurate knowledge of the source's mean photon number. Finite calibration precision or an active manipulation by an attacker may cause the actual emitted photon number to deviate from the known value. We model effects of this deviation on the security of three quantum communication protocols: the Bennett-Brassard 1984 (BB84) quantum key distribution (QKD) protocol without decoy states, Scarani-Acín-Ribordy-Gisin 2004 (SARG04) QKD protocol, and a coin-tossing protocol. For QKD we model both a strong attack using technology possible in principle and a realistic attack bounded by today's technology. To maintain the mean photon number in two-way systems, such as plug-and-play and relativistic quantum cryptography schemes, bright pulse energy incoming from the communication channel must be monitored. Implementation of a monitoring detector has largely been ignored so far, except for ID Quantique's commercial QKD system Clavis2. We scrutinize this implementation for security problems and show that designing a hack-proof pulse-energy-measuring detector is far from trivial. Indeed, the first implementation has three serious flaws confirmed experimentally, each of which may be exploited in a cleverly constructed Trojan-horse attack. We discuss requirements for a loophole-free implementation of the monitoring detector.
Toddle temporal-spatial deviation index: Assessment of pediatric gait.
Cahill-Rowley, Katelyn; Rose, Jessica
2016-09-01
This research aims to develop a gait index for use in the pediatric clinic as well as research, that quantifies gait deviation in 18-22 month-old children: the Toddle Temporal-spatial Deviation Index (Toddle TDI). 81 preterm children (≤32 weeks) with very-low-birth-weights (≤1500g) and 42 full-term TD children aged 18-22 months, adjusted for prematurity, walked on a pressure-sensitive mat. Preterm children were administered the Bayley Scales of Infant Development-3rd Edition (BSID-III). Principle component analysis of TD children's temporal-spatial gait parameters quantified raw gait deviation from typical, normalized to an average(standard deviation) Toddle TDI score of 100(10), and calculated for all participants. The Toddle TDI was significantly lower for preterm versus TD children (86 vs. 100, p=0.003), and lower in preterm children with <85 vs. ≥85 BSID-III motor composite scores (66 vs. 89, p=0.004). The Toddle TDI, which by design plateaus at typical average (BSID-III gross motor 8-12), correlated with BSID-III gross motor (r=0.60, p<0.001) and not fine motor (r=0.08, p=0.65) in preterm children with gross motor scores ≤8, suggesting sensitivity to gross motor development. The Toddle TDI demonstrated sensitivity and specificity to gross motor function in very-low-birth-weight preterm children aged 18-22 months, and has been potential as an easily-administered, revealing clinical gait metric. PMID:27454230
ERIC Educational Resources Information Center
Hewitt, Paul G.
2004-01-01
Some teachers have difficulty understanding Bernoulli's principle particularly when the principle is applied to the aerodynamic lift. Some teachers favor using Newton's laws instead of Bernoulli's principle to explain the physics behind lift. Some also consider Bernoulli's principle too difficult to explain to students and avoid teaching it…
Static ocular counterroll reflex in skew deviation
Chandrakumar, M.; Blakeman, A.; Goltz, H.C.; Sharpe, J.A.
2011-01-01
Objective: The static ocular counterroll (OCR) reflex generates partially compensatory torsional eye movements during head roll. It is mediated by the utricle in the inner ear. Skew deviation is a vertical strabismus thought to be caused by imbalance in the utriculo-ocular pathway. We hypothesized that if skew deviation is indeed caused by damage to this reflex pathway, patients with skew deviation would show abnormal OCR. Methods: Eighteen patients with skew deviation caused by brainstem or cerebellar lesions and 18 normal participants viewed a target at 1 m. Ocular responses to static passive head roll-tilts of approximately 20° were recorded using search coils. Static OCR gain was calculated as the change in torsional eye position divided by the change in head position during sustained head roll. Perception of the subjective visual vertical (SVV) was also measured. Results: Group mean OCR gain was reduced by 45% in patients. At an individual level, OCR gains were asymmetric between eyes and between torsional directions in 90% of patients. In addition, the hypotropic eye incyclotorting gain was lower than the hypertropic eye excyclotorting gain during head roll toward the hypotropic eye in 94% of patients. No consistent pattern of gain asymmetry was found during head roll toward the hypertropic eye. The SVV was tilted toward the hypotropic eye. Conclusion: Static OCR gain is significantly reduced in skew deviation. Interocular and directional gain asymmetries are also prevalent. The asymmetries provide further evidence that disruption of the utriculo-ocular pathway is a mechanism for skew deviation. PMID:21813791
14 CFR 125.3 - Deviation authority.
Code of Federal Regulations, 2013 CFR
2013-01-01
... data recorder requirements of this part will be granted. Any previously issued deviation from the flight data recorder requirements of this part is no longer valid. ... nearest Flight Standards District Office, not less than 60 days prior to the date of intended...
14 CFR 125.3 - Deviation authority.
Code of Federal Regulations, 2014 CFR
2014-01-01
... data recorder requirements of this part will be granted. Any previously issued deviation from the flight data recorder requirements of this part is no longer valid. ... nearest Flight Standards District Office, not less than 60 days prior to the date of intended...
14 CFR 125.3 - Deviation authority.
Code of Federal Regulations, 2012 CFR
2012-01-01
... data recorder requirements of this part will be granted. Any previously issued deviation from the flight data recorder requirements of this part is no longer valid. ... nearest Flight Standards District Office, not less than 60 days prior to the date of intended...
14 CFR 125.3 - Deviation authority.
Code of Federal Regulations, 2011 CFR
2011-01-01
... data recorder requirements of this part will be granted. Any previously issued deviation from the flight data recorder requirements of this part is no longer valid. ... nearest Flight Standards District Office, not less than 60 days prior to the date of intended...
14 CFR 125.3 - Deviation authority.
Code of Federal Regulations, 2010 CFR
2010-01-01
... data recorder requirements of this part will be granted. Any previously issued deviation from the flight data recorder requirements of this part is no longer valid. ... nearest Flight Standards District Office, not less than 60 days prior to the date of intended...
41 CFR 115-1.110 - Deviations.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviations. 115-1.110 Section 115-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) ENVIRONMENTAL PROTECTION AGENCY 1-INTRODUCTION 1.1-Regulation System § 115-1.110...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110...
Code of Federal Regulations, 2013 CFR
2013-01-01
...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...
Code of Federal Regulations, 2014 CFR
2014-01-01
...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Deviations. Â§ 1260.7 Section Â§ 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...
Code of Federal Regulations, 2012 CFR
2012-01-01
...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...
Code of Federal Regulations, 2011 CFR
2011-01-01
...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 15 2014-01-01 2014-01-01 false Deviations. 2502.3 Section 2502.3 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE AGRICULTURAL CAREER AND EMPLOYMENT (ACE) GRANTS PROGRAM General Information § 2502.3...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 15 2013-01-01 2013-01-01 false Deviations. 2502.3 Section 2502.3 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE AGRICULTURAL CAREER AND EMPLOYMENT (ACE) GRANTS PROGRAM General Information § 2502.3...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 15 2012-01-01 2012-01-01 false Deviations. 2502.3 Section 2502.3 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE AGRICULTURAL CAREER AND EMPLOYMENT (ACE) GRANTS PROGRAM General Information § 2502.3...
Code of Federal Regulations, 2012 CFR
2012-04-01
... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Deviations. 84.4 Section 84.4 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Deviations. 84.4 Section 84.4 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND...
Code of Federal Regulations, 2013 CFR
2013-04-01
... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Deviations. 84.4 Section 84.4 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND...
Code of Federal Regulations, 2011 CFR
2011-04-01
... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Deviations. 84.4 Section 84.4 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND...
Code of Federal Regulations, 2014 CFR
2014-04-01
... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Deviations. 84.4 Section 84.4 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND...
41 CFR 115-1.110 - Deviations.
Code of Federal Regulations, 2011 CFR
2011-01-01
... Section 115-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) ENVIRONMENTAL PROTECTION AGENCY 1-INTRODUCTION 1.1-Regulation System § 115-1.110 Deviations. Where deemed necessary that regulations set forth in the FPMR or EPPMR be changed in the interest...
41 CFR 115-1.110 - Deviations.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Section 115-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) ENVIRONMENTAL PROTECTION AGENCY 1-INTRODUCTION 1.1-Regulation System § 115-1.110 Deviations. Where deemed necessary that regulations set forth in the FPMR or EPPMR be changed in the interest...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Deviations. 1260.104 Section 1260.104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS Uniform Administrative Requirements for Grants and Cooperative Agreements With Institutions of Higher...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Deviations. 1260.104 Section 1260.104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS Uniform Administrative Requirements for Grants and Cooperative Agreements With Institutions of Higher...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Deviations. 1260.104 Section 1260.104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS Uniform Administrative Requirements for Grants and Cooperative Agreements With Institutions of Higher...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Deviations. 1260.104 Section 1260.104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS Uniform Administrative Requirements for Grants and Cooperative Agreements With Institutions of Higher...
14 CFR § 1260.104 - Deviations.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Deviations. Â§ 1260.104 Section Â§ 1260.104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS Uniform Administrative Requirements for Grants and Cooperative Agreements With Institutions of Higher...
Manifestations of Deviation in the Adolescent Subculture
ERIC Educational Resources Information Center
Sobkin, V. S.; Abrosimova, Z. B.; Adamchuk, D. V.; Baranova, E. V.
2005-01-01
In this article the authors look at questions relating to school students' attitudes toward types of deviation such as smoking and the use of alcohol and narcotics. The empirical material is divided into the following topics: how widespread these forms of behavior are; motives that cause adolescents to start smoking, using alcohol, and taking…
48 CFR 201.404 - Class deviations.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Air Force, and the Directors of the Defense Commissary Agency, the Defense Contract Management Agency, and the Defense Logistics Agency, may approve any class deviation, other than those described in 201... department or agency; (B) Have a significant cost or administrative impact on contractors or offerors;...
48 CFR 201.404 - Class deviations.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Air Force, and the Directors of the Defense Commissary Agency, the Defense Contract Management Agency, and the Defense Logistics Agency, may approve any class deviation, other than those described in 201... department or agency; (B) Have a significant cost or administrative impact on contractors or offerors;...
41 CFR 109-1.5304 - Deviations.
Code of Federal Regulations, 2010 CFR
2010-07-01
... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...
41 CFR 109-1.5304 - Deviations.
Code of Federal Regulations, 2011 CFR
2011-01-01
... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle...
Code of Federal Regulations, 2010 CFR
2010-01-01
...” within the meaning of the Paperwork Reduction Act (44 U.S.C. 35) and its implementation in 5 CFR part... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Deviations. 1260.7 Section 1260.7 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS...
Bodily Deviations and Body Image in Adolescence
ERIC Educational Resources Information Center
Vilhjalmsson, Runar; Kristjansdottir, Gudrun; Ward, Dianne S.
2012-01-01
Adolescents with unusually sized or shaped bodies may experience ridicule, rejection, or exclusion based on their negatively valued bodily characteristics. Such experiences can have negative consequences for a person's image and evaluation of self. This study focuses on the relationship between bodily deviations and body image and is based on a…
Voice Deviations and Coexisting Communication Disorders.
ERIC Educational Resources Information Center
St. Louis, Kenneth O.; And Others
1992-01-01
This study examined the coexistence of other communicative disorders with voice disorders in about 3,400 children in grades 1-12 at 100 sites throughout the United States. The majority of voice-disordered children had coexisting articulation deviations and also differed from controls on two language measures and mean pure-tone hearing thresholds.…
Code of Federal Regulations, 2010 CFR
2010-07-01
... award may be approved by DoD Components in accordance with procedures stated in 32 CFR 21.335(a) and 21.340. (b) Small awards. DoD Components may apply less restrictive requirements than the provisions of... Components shall request approval for such deviations in accordance with 32 CFR 21.335(b) and 21.340....
Code of Federal Regulations, 2011 CFR
2011-07-01
... award may be approved by DoD Components in accordance with procedures stated in 32 CFR 21.335(a) and 21.340. (b) Small awards. DoD Components may apply less restrictive requirements than the provisions of... Components shall request approval for such deviations in accordance with 32 CFR 21.335(b) and 21.340....
Code of Federal Regulations, 2010 CFR
2010-10-01
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Deviations. 12.904 Section 12.904 Public Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... Institutions of Higher Education, Hospitals, and Other Non-Profit Organizations General § 12.904...
Code of Federal Regulations, 2010 CFR
2010-01-01
... Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS (OMB CIRCULAR A-110) General § 215.4 Deviations. The Office of Management and Budget (OMB)...
Association between septal deviation and sinonasal papilloma.
Nomura, Kazuhiro; Ogawa, Takenori; Sugawara, Mitsuru; Honkura, Yohei; Oshima, Hidetoshi; Arakawa, Kazuya; Oshima, Takeshi; Katori, Yukio
2013-01-01
Sinonasal papilloma is a common benign epithelial tumor of the sinonasal tract and accounts for 0.5% to 4% of all nasal tumors. The etiology of sinonasal papilloma remains unclear, although human papilloma virus has been proposed as a major risk factor. Other etiological factors, such as anatomical variations of the nasal cavity, may be related to the pathogenesis of sinonasal papilloma, because deviated nasal septum is seen in patients with chronic rhinosinusitis. We, therefore, investigated the involvement of deviated nasal septum in the development of sinonasal papilloma. Preoperative computed tomography or magnetic resonance imaging findings of 83 patients with sinonasal papilloma were evaluated retrospectively. The side of papilloma and the direction of septal deviation showed a significant correlation. Septum deviated to the intact side in 51 of 83 patients (61.4%) and to the affected side in 18 of 83 patients (21.7%). Straight or S-shaped septum was observed in 14 of 83 patients (16.9%). Even after excluding 27 patients who underwent revision surgery and 15 patients in whom the papilloma touched the concave portion of the nasal septum, the concave side of septal deviation was associated with the development of sinonasal papilloma (p = 0.040). The high incidence of sinonasal papilloma in the concave side may reflect the consequences of the traumatic effects caused by wall shear stress of the high-velocity airflow and the increased chance of inhaling viruses and pollutants. The present study supports the causative role of human papilloma virus and toxic chemicals in the occurrence of sinonasal papilloma.
NASA Astrophysics Data System (ADS)
Areshkin, Denis A.; Nikolić, Branislav K.
2010-04-01
The recent fabrication of graphene nanoribbon (GNR) field-effect transistors poses a challenge for first-principles modeling of carbon nanoelectronics due to many thousand atoms present in the device. The state of the art quantum transport algorithms, based on the nonequilibrium Green function formalism combined with the density-functional theory (NEGF-DFT), were originally developed to calculate self-consistent electron density in equilibrium and at finite bias voltage (as a prerequisite to obtain conductance or current-voltage characteristics, respectively) for small molecules attached to metallic electrodes where only a few hundred atoms are typically simulated. Here we introduce combination of two numerically efficient algorithms which make it possible to extend the NEGF-DFT framework to device simulations involving large number of atoms. Our first algorithm offers an alternative to the usual evaluation of the equilibrium part of electron density via numerical contour integration of the retarded Green function in the upper complex half-plane. It is based on the replacement of the Fermi function f(E) with an analytic function f˜(E) coinciding with f(E) inside the integration range along the real axis, but decaying exponentially in the upper complex half-plane. Although f˜(E) has infinite number of poles, whose positions and residues are determined analytically, only a finite number of those poles have non-negligible residues. We also discuss how this algorithm can be extended to compute the nonequilibrium contribution to electron density, thereby evading cumbersome real-axis integration (within the bias voltage window) of NEGFs which is very difficult to converge for systems with large number of atoms while maintaining current conservation. Our second algorithm combines the recursive formulas with the geometrical partitioning of an arbitrary multiterminal device into nonuniform segments in order to reduce the computational complexity of the retarded Green
NASA Technical Reports Server (NTRS)
Litvin, Faydor L.; Kuan, Chihping; Zhang, YI
1991-01-01
A numerical method is developed for the minimization of deviations of real tooth surfaces from the theoretical ones. The deviations are caused by errors of manufacturing, errors of installment of machine-tool settings and distortion of surfaces by heat-treatment. The deviations are determined by coordinate measurements of gear tooth surfaces. The minimization of deviations is based on the proper correction of initially applied machine-tool settings. The contents of accomplished research project cover the following topics: (1) Descriptions of the principle of coordinate measurements of gear tooth surfaces; (2) Deviation of theoretical tooth surfaces (with examples of surfaces of hypoid gears and references for spiral bevel gears); (3) Determination of the reference point and the grid; (4) Determination of the deviations of real tooth surfaces at the points of the grid; and (5) Determination of required corrections of machine-tool settings for minimization of deviations. The procedure for minimization of deviations is based on numerical solution of an overdetermined system of n linear equations in m unknowns (m much less than n ), where n is the number of points of measurements and m is the number of parameters of applied machine-tool settings to be corrected. The developed approach is illustrated with numerical examples.
Equivalence Principle and Gravitational Redshift
Hohensee, Michael A.; Chu, Steven; Mueller, Holger; Peters, Achim
2011-04-15
We investigate leading order deviations from general relativity that violate the Einstein equivalence principle in the gravitational standard model extension. We show that redshift experiments based on matter waves and clock comparisons are equivalent to one another. Consideration of torsion balance tests, along with matter-wave, microwave, optical, and Moessbauer clock tests, yields comprehensive limits on spin-independent Einstein equivalence principle-violating standard model extension terms at the 10{sup -6} level.
Century-Scale of Standard Deviation in Europe Historical Temperature Records
NASA Astrophysics Data System (ADS)
Xie, F.
2015-12-01
The standard deviation (STD) variability in long historical temperature records in Europe is analyzed. It is found that STD is changeable with time, and a century-scale variation is revealed, which further indicates a century-scale intensity modulation of the large-scale temperature variability. The Atlantic multidecadal oscillation (AMO) can cause significant impacts in standard deviation. During the periods of 1870-1910 and 1950-80, increasing standard deviation corresponds to increasing AMO index, while the periods of 1920-50 and 1980-2000 decreasing standard deviation corresponds to decreasing AMO index. The findings herein suggest a new perspective on the understanding of climatic change
Deviations from LTE in a stellar atmosphere
NASA Technical Reports Server (NTRS)
Kalkofen, W.; Klein, R. I.; Stein, R. F.
1979-01-01
Deviations for LTE are investigated in an atmosphere of hydrogen atoms with one bound level, satisfying the equations of radiative, hydrostatic, and statistical equilibrium. The departure coefficient and the kinetic temperature as functions of the frequency dependence of the radiative cross section are studied analytically and numerically. Near the outer boundary of the atmosphere, the departure coefficient is smaller than unity when the radiative cross section grows with frequency faster than with the square of frequency; it exceeds unity otherwise. Far from the boundary the departure coefficient tends to exceed unity for any frequency dependence of the radiative cross section. Overpopulation always implies that the kinetic temperature in the statistical-equilibrium atmosphere is higher than the temperature in the corresponding LTE atmosphere. Upper and lower bounds on the kinetic temperature are given for an atmosphere with deviations from LTE only in the optically shallow layers when the emergent intensity can be described by a radiation temperature.
Note onset deviations as musical piece signatures.
Serrà, Joan; Özaslan, Tan Hakan; Arcos, Josep Lluis
2013-01-01
A competent interpretation of a musical composition presents several non-explicit departures from the written score. Timing variations are perhaps the most important ones: they are fundamental for expressive performance and a key ingredient for conferring a human-like quality to machine-based music renditions. However, the nature of such variations is still an open research question, with diverse theories that indicate a multi-dimensional phenomenon. In the present study, we consider event-shift timing variations and show that sequences of note onset deviations are robust and reliable predictors of the musical piece being played, irrespective of the performer. In fact, our results suggest that only a few consecutive onset deviations are already enough to identify a musical composition with statistically significant accuracy. We consider a mid-size collection of commercial recordings of classical guitar pieces and follow a quantitative approach based on the combination of standard statistical tools and machine learning techniques with the semi-automatic estimation of onset deviations. Besides the reported results, we believe that the considered materials and the methodology followed widen the testing ground for studying musical timing and could open new perspectives in related research fields.
Note Onset Deviations as Musical Piece Signatures
Serrà, Joan; Özaslan, Tan Hakan; Arcos, Josep Lluis
2013-01-01
A competent interpretation of a musical composition presents several non-explicit departures from the written score. Timing variations are perhaps the most important ones: they are fundamental for expressive performance and a key ingredient for conferring a human-like quality to machine-based music renditions. However, the nature of such variations is still an open research question, with diverse theories that indicate a multi-dimensional phenomenon. In the present study, we consider event-shift timing variations and show that sequences of note onset deviations are robust and reliable predictors of the musical piece being played, irrespective of the performer. In fact, our results suggest that only a few consecutive onset deviations are already enough to identify a musical composition with statistically significant accuracy. We consider a mid-size collection of commercial recordings of classical guitar pieces and follow a quantitative approach based on the combination of standard statistical tools and machine learning techniques with the semi-automatic estimation of onset deviations. Besides the reported results, we believe that the considered materials and the methodology followed widen the testing ground for studying musical timing and could open new perspectives in related research fields. PMID:23935971
Note onset deviations as musical piece signatures.
Serrà, Joan; Özaslan, Tan Hakan; Arcos, Josep Lluis
2013-01-01
A competent interpretation of a musical composition presents several non-explicit departures from the written score. Timing variations are perhaps the most important ones: they are fundamental for expressive performance and a key ingredient for conferring a human-like quality to machine-based music renditions. However, the nature of such variations is still an open research question, with diverse theories that indicate a multi-dimensional phenomenon. In the present study, we consider event-shift timing variations and show that sequences of note onset deviations are robust and reliable predictors of the musical piece being played, irrespective of the performer. In fact, our results suggest that only a few consecutive onset deviations are already enough to identify a musical composition with statistically significant accuracy. We consider a mid-size collection of commercial recordings of classical guitar pieces and follow a quantitative approach based on the combination of standard statistical tools and machine learning techniques with the semi-automatic estimation of onset deviations. Besides the reported results, we believe that the considered materials and the methodology followed widen the testing ground for studying musical timing and could open new perspectives in related research fields. PMID:23935971
Variability of Ocular Deviation in Strabismus
Economides, John R.; Adams, Daniel L.; Horton, Jonathan C.
2015-01-01
IMPORTANCE In strabismus, the fixating eye conveys the direction of gaze while the fellow eye points at a peripheral location in space. The stability of the eyes may be reduced by the absence of a common target. OBJECTIVE To quantify the stability of eye position in strabismus and to measure variability in the ocular deviation. DESIGN, SETTING, AND PARTICIPANTS From 2010 to 2014, a prospective comparative case study of 25 patients with alternating exotropia with normal visual acuity in each eye and 25 control individuals was conducted in a laboratory at a tertiary eye center. A video eye tracker was used to measure the position of each eye while participants alternated fixation on the center of a cross under dichoptic conditions or scanned pictures of natural scenes. MAIN OUTCOMES AND MEASURES Spatial and temporal variability in the position of the fixating eye and the nonfixating eye in patients with strabismus and control individuals, quantified by the log area of ellipses containing 95% of eye positions or mean SDs of eye position. RESULTS In the 25 patients with strabismus, the mean (SD) age was 28 (14) years (range, 8–55 years) and the mean (SD) ocular deviation was 14.2° (5.9°) (range, 4.4°–22.4°). In the patients with strabismus, the mean position variability (1.80 log units; 95% CI, 1.66–1.93) for the deviating eye was greater than for the fixating eye (1.26 log units; 95% CI, 1.17–1.35) (P < .001). The fixating eye of patients with strabismus was more variable in position than the fixating eye of individuals without strabismus (0.98 log units; 95% CI, 0.88–1.08) (P < .005). CONCLUSIONS AND RELEVANCE In patients with strabismus, even without amblyopia, the deviated eye is more variable in position than the fixating eye. Both eyes are less stable in position than the eyes of control individuals, which indicates that strabismus impairs the ability to fixate targets steadily. Saccades contribute to variability of the deviation angle because they
9 CFR 318.308 - Deviations in processing.
Code of Federal Regulations, 2010 CFR
2010-01-01
...) Deviations in processing (or process deviations) must be handled according to: (1)(i) A HACCP plan for canned...) of this section. (c) (d) Procedures for handling process deviations where the HACCP plan...
NASA Astrophysics Data System (ADS)
Prins, Steven L.; Blatchford, James; Olubuyide, Oluwamuyiwa; Riley, Deborah; Chang, Simon; Hong, Qi-Zhong; Kim, T. S.; Borges, Ricardo; Lin, Li
2009-03-01
As design rules and corresponding logic standard cell layouts continue to shrink node-on-node in accordance with Moore's law, complex 2D interactions, both intra-cell and between cells, become much more prominent. For example, in lithography, lack of scaling of λ/NA implies aggressive use of resolution enhancement techniques to meet logic scaling requirements-resulting in adverse effects such as 'forbidden pitches'-and also implies an increasing range of optical influence relative to cell size. These adverse effects are therefore expected to extend well beyond the cell boundary, leading to lithographic marginalities that occur only when a given cell is placed "in context" with other neighboring cells in a variable design environment [1]. This context dependence is greatly exacerbated by increased use of strain engineering techniques such as SiGe and dual-stress liners (DSL) to enhance transistor performance, both of which also have interaction lengths on the order of microns. The use of these techniques also breaks the formerly straightforward connection between lithographic 'shapes' and end-of-line electrical performance, thus making the formulation of design rules that are robust to process variations and complex 2D interactions more difficult. To address these issues, we have developed a first-principles-based simulation flow to study contextdependent electrical effects in layout, arising not only from lithography, but also from stress and interconnect parasitic effects. This flow is novel in that it can be applied to relatively large layout clips- required for context-dependent analysis-without relying on semi-empirical or 'black-box' models for the fundamental electrical effects. The first-principles-based approach is ideal for understanding contextdependent effects early in the design phase, so that they can be mitigated through restrictive design rules. The lithographic simulations have been discussed elsewhere [1] and will not be presented in detail. The
Standard deviation of scatterometer measurements from space.
NASA Technical Reports Server (NTRS)
Fischer, R. E.
1972-01-01
The standard deviation of scatterometer measurements has been derived under assumptions applicable to spaceborne scatterometers. Numerical results are presented which show that, with sufficiently long integration times, input signal-to-noise ratios below unity do not cause excessive degradation of measurement accuracy. The effects on measurement accuracy due to varying integration times and changing the ratio of signal bandwidth to IF filter-noise bandwidth are also plotted. The results of the analysis may resolve a controversy by showing that in fact statistically useful scatterometer measurements can be made from space using a 20-W transmitter, such as will be used on the S-193 experiment for Skylab-A.
ERIC Educational Resources Information Center
Hamp-Lyons, Liz
2009-01-01
Davison and Leung (this issue) describe the field of teacher-based English language assessment as having "much variability, a lack of systematic principles and procedures and a dearth of information as to the impact of teacher-based assessments on learning and teaching" (p. 389). In this article, the author briefly explores an example of…
48 CFR 552.252-5 - Authorized Deviations in Provisions.
Code of Federal Regulations, 2010 CFR
2010-10-01
... CFR chapter 1) provision by the addition of “(DEVIATION)” after the date of the provision, if the provision is not published in the General Services Administration Acquisition Regulation (48 CFR chapter 5... provision: Authorized Deviations in Provisions (Deviation FAR 52.252-5) (SEP 1999) (a) Deviations to...
48 CFR 552.252-6 - Authorized Deviations in Clauses.
Code of Federal Regulations, 2010 CFR
2010-10-01
...: Authorized Deviations in Clauses (Deviation FAR 52.252-6) (SEP 1999) (a) Deviations to FAR clauses. (1) This solicitation or contract indicates any authorized deviation to a Federal Acquisition Regulation (48 CFR chapter... published in the General Services Administration Acquisition Regulation (48 CFR chapter 5). (2)...
ERIC Educational Resources Information Center
MacBeath, John; Swaffield, Sue; Frost, David
2009-01-01
This article provides an overview of the "Carpe Vitam: Leadership for Learning" project, accounting for its provenance and purposes, before focusing on the principles for practice that constitute an important part of the project's legacy. These principles framed the dialogic process that was a dominant feature of the project and are presented,…
NASA Astrophysics Data System (ADS)
Lamport, Leslie
2012-08-01
Buridan's principle asserts that a discrete decision based upon input having a continuous range of values cannot be made within a bounded length of time. It appears to be a fundamental law of nature. Engineers aware of it can design devices so they have an infinitessimal probability of not making a decision quickly enough. Ignorance of the principle could have serious consequences.
Spotting deviations from R2 inflation
NASA Astrophysics Data System (ADS)
de la Cruz-Dombriz, Álvaro; Elizalde, Emilio; Odintsov, Sergei D.; Sáez-Gómez, Diego
2016-05-01
We discuss the soundness of inflationary scenarios in theories beyond the Starobinsky model, namely a class of theories described by arbitrary functions of the Ricci scalar and the K-essence field. We discuss the pathologies associated with higher-order equations of motion which will be shown to constrain the stability of this class of theories. We provide a general framework to calculate the slow-roll parameters and the corresponding mappings to the theory parameters. For paradigmatic gravitational models within the class of theories under consideration we illustrate the power of the Planck/Bicep2 latest results to constrain such gravitational Lagrangians. Finally, bounds for potential deviations from Starobinsky-like inflation are derived.
Background and principles of self-organizing jet-emulsion metallurgical unit
NASA Astrophysics Data System (ADS)
Tsymbal, V. P.; Kozhemyachenko, V. I.; Rybenko, I. A.; Mochalov, S. P.; Padalko, A. G.; Kalashnikov, S. N.; Krasnoperov, S. Yu; Ermakova, L. A.; Olennikov, A. A.
2016-09-01
The basic principles laid in the creation of a new jet-emulsion process and metallurgical unit were considered. Development of self-organizing oscillator reactor, bottom feed of the prepared in it combustible mixture to the column reactor and a large deviation from the thermodynamic equilibrium allow dissipative structure to be created, and thus control the ratio of reducing and oxidizing processes, the carbon content in the metal.
NASA Astrophysics Data System (ADS)
Svenson, Eric Johan
Participants on the Invincible America Assembly in Fairfield, Iowa, and neighboring Maharishi Vedic City, Iowa, practicing Maharishi Transcendental Meditation(TM) (TM) and the TM-Sidhi(TM) programs in large groups, submitted written experiences that they had had during, and in some cases shortly after, their daily practice of the TM and TM-Sidhi programs. Participants were instructed to include in their written experiences only what they observed and to leave out interpretation and analysis. These experiences were then read by the author and compared with principles and phenomena of modern physics, particularly with quantum theory, astrophysics, quantum cosmology, and string theory as well as defining characteristics of higher states of consciousness as described by Maharishi Vedic Science. In all cases, particular principles or phenomena of physics and qualities of higher states of consciousness appeared qualitatively quite similar to the content of the given experience. These experiences are presented in an Appendix, in which the corresponding principles and phenomena of physics are also presented. These physics "commentaries" on the experiences were written largely in layman's terms, without equations, and, in nearly every case, with clear reference to the corresponding sections of the experiences to which a given principle appears to relate. An abundance of similarities were apparent between the subjective experiences during meditation and principles of modern physics. A theoretic framework for understanding these rich similarities may begin with Maharishi's theory of higher states of consciousness provided herein. We conclude that the consistency and richness of detail found in these abundant similarities warrants the further pursuit and development of such a framework.
Large deviations in boundary-driven systems: Numerical evaluation and effective large-scale behavior
NASA Astrophysics Data System (ADS)
Bunin, Guy; Kafri, Yariv; Podolsky, Daniel
2012-07-01
We study rare events in systems of diffusive fields driven out of equilibrium by the boundaries. We present a numerical technique and use it to calculate the probabilities of rare events in one and two dimensions. Using this technique, we show that the probability density of a slowly varying configuration can be captured with a small number of long-wavelength modes. For a configuration which varies rapidly in space this description can be complemented by a local-equilibrium assumption.
Yue, Ning J.; Kim, Sung; Jabbour, Salma; Narra, Venkat; Haffty, Bruce G.
2007-11-15
Image guided radiotherapy technologies are being increasingly utilized in the treatment of various cancers. These technologies have enhanced the ability to detect temporal and spatial deviations of the target volume relative to planned radiation beams. Correcting these detected deviations may, in principle, improve the accuracy of dose delivery to the target. However, in many situations, a clinical decision has to be made as to whether it is necessary to correct some of the deviations since the relevant dosimetric impact may or may not be significant, and the corresponding corrective action may be either impractical or time consuming. Ideally this decision should be based on objective and reproducible criteria rather than subjective judgment. In this study, a strategy is proposed for the objective evaluation of the necessity of deviation correction during the treatment verification process. At the treatment stage, without any alteration from the planned beams, the treatment beams should provide the desired dose coverage to the geometric volume identical to the planning target volume (PTV). Given this fact, the planned dose distribution and PTV geometry were used to compute the dose coverage and PTV enclosure of the clinical target volume (CTV) that was detected from imaging during the treatment setup verification. The spatial differences between the detected CTV and the planning CTV are essentially the target deviations. The extent of the PTV enclosure of the detected CTV as well as its dose coverage were used as criteria to evaluate the necessity of correcting any of the target deviations. This strategy, in principle, should be applicable to any type of target deviations, including both target deformable and positional changes and should be independent of how the deviations are detected. The proposed strategy was used on two clinical prostate cancer cases. In both cases, gold markers were implanted inside the prostate for the purpose of treatment setup
Effect of stress on energy flux deviation of ultrasonic waves in GR/EP composites
NASA Technical Reports Server (NTRS)
Prosser, William H.; Kriz, R. D.; Fitting, Dale W.
1990-01-01
Ultrasonic waves suffer energy flux deviation in graphite/epoxy because of the large anisotropy. The angle of deviation is a function of the elastic coefficients. For nonlinear solids, these coefficients and thus the angle of deviation is a function of stress. Acoustoelastic theory was used to model the effect of stress on flux deviation for unidirectional T300/5208 using previously measured elastic coefficients. Computations were made for uniaxial stress along the x3 axis (fiber axis) and the x1 for waves propagating in the x1x3 plane. These results predict a shift as large as three degrees for the quasi-transverse wave. The shift in energy flux offers a new nondestructive technique of evaluating stress in composites.
The Role of Burden and Deviation in Ostracizing Others.
Wesselmann, Eric D; Wirth, James H; Pryor, John B; Reeder, Glenn D; Williams, Kipling D
2015-01-01
Ostracism (being excluded and ignored) is a painful experience, so why do individuals ostracize others? Previous research suggests individuals often ostracize those who are deviate, but not always. We posit that there may be two types of deviation, burdensome and non-burdensome, and the former is most likely to be ostracized. Study 1 manipulated burdensome deviation by programming a group member to perform more slowly (8 or 16 sec.) than others (4 sec.) in a virtual ball-toss game. Participants perceived slower players as more burdensome and deviate than normal speed players. Additionally, participants ostracized (gave fewer ball tosses to) the slowest player. Study 2 examined participant responses to both burdensome deviation (8- and 16-sec. players) and non-burdensome deviation (goth appearance). Participants again perceived the slower players to be burdensome and deviate, and ostracized them. They perceived the goth player to be deviate but not burdensome and did not ostracize this player. PMID:26267129
40 CFR 63.1965 - What is a deviation?
Code of Federal Regulations, 2010 CFR
2010-07-01
... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What is a deviation? 63.1965 Section 63... Requirements § 63.1965 What is a deviation? A deviation is defined in § 63.1990. For the purposes of...
40 CFR 63.1965 - What is a deviation?
Code of Federal Regulations, 2011 CFR
2011-07-01
... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... 40 Protection of Environment 12 2011-07-01 2009-07-01 true What is a deviation? 63.1965 Section 63... Requirements § 63.1965 What is a deviation? A deviation is defined in § 63.1990. For the purposes of...
40 CFR 63.1965 - What is a deviation?
Code of Federal Regulations, 2013 CFR
2013-07-01
... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... 40 Protection of Environment 13 2013-07-01 2012-07-01 true What is a deviation? 63.1965 Section 63... Compliance Requirements § 63.1965 What is a deviation? A deviation is defined in § 63.1990. For the...
40 CFR 63.1965 - What is a deviation?
Code of Federal Regulations, 2014 CFR
2014-07-01
... described in 40 CFR 60.758(c)(1) of subpart WWW are exceeded. (b) A deviation occurs when 1 hour or more of... 40 Protection of Environment 13 2014-07-01 2014-07-01 false What is a deviation? 63.1965 Section... Compliance Requirements § 63.1965 What is a deviation? A deviation is defined in § 63.1990. For the...
Visible-light absorption and large band-gap bowing of GaN_{1-x}Sb_{x} from first principles
Sheetz, R. Michael; Richter, Ernst; Andriotis, Antonis N.; Lisenkov, Sergey; Pendyala, Chandrashekhar; Sunkara, Mahendra K.; Menon, Madhu
2011-08-01
Applicability of the Ga(Sb_{x})N_{1-x} alloys for practical realization of photoelectrochemical water splitting is investigated using first-principles density functional theory incorporating the local density approximation and generalized gradient approximation plus the Hubbard U parameter formalism. Our calculations reveal that a relatively small concentration of Sb impurities is sufficient to achieve a significant narrowing of the band gap, enabling absorption of visible light. Theoretical results predict that Ga(Sb_{x})N_{1-x} alloys with 2-eV band gaps straddle the potential window at moderate to low pH values, thus indicating that dilute Ga(Sb_{x})N_{1-x} alloys could be potential candidates for splitting water under visible light irradiation.
Visible-light absorption and large band-gap bowing of GaN1-xSbx from first principles
Sheetz, R. Michael; Richter, Ernst; Andriotis, Antonis N.; Lisenkov, Sergey; Pendyala, Chandrashekhar; Sunkara, Mahendra K.; Menon, Madhu
2011-08-01
Applicability of the Ga(Sbx)N1-x alloys for practical realization of photoelectrochemical water splitting is investigated using first-principles density functional theory incorporating the local density approximation and generalized gradient approximation plus the Hubbard U parameter formalism. Our calculations reveal that a relatively small concentration of Sb impurities is sufficient to achieve a significant narrowing of the band gap, enabling absorption of visible light. Theoretical results predict that Ga(Sbx)N1-x alloys with 2-eV band gaps straddle the potential window at moderate to low pH values, thus indicating that dilute Ga(Sbx)N1-x alloys could be potential candidates for splitting water under visible light irradiation.
NASA Astrophysics Data System (ADS)
Ceotto, Michele; Tantardini, Gian Franco; Aspuru-Guzik, Alán
2011-12-01
Semiclassical methods face numerical challenges as the dimensionality of the system increases. In the general context of the theory of differential equations, this is known as the "curse of dimensionality." In the present manuscript, we apply the recently-introduced multi-coherent states semiclassical initial value representation (MC-SC-IVR) approach to extend the applicability of first-principles semiclassical calculations. The proposed strategy involves the use of non-local coherent states with the goal of increasing accuracy in the Fourier transforms, and on the other hand, allows for the selection of peaks of different frequencies. The ability to filter desired peaks is important for analyzing the power spectra of complex systems. The MC-SC-IVR approach allows us to solve a 19-dimensional test system and to resolve on-the-fly the power spectra of the formaldehyde molecule with very few classical trajectories.
Ceotto, Michele; Tantardini, Gian Franco; Aspuru-Guzik, Alán
2011-12-01
Semiclassical methods face numerical challenges as the dimensionality of the system increases. In the general context of the theory of differential equations, this is known as the "curse of dimensionality." In the present manuscript, we apply the recently-introduced multi-coherent states semiclassical initial value representation (MC-SC-IVR) approach to extend the applicability of first-principles semiclassical calculations. The proposed strategy involves the use of non-local coherent states with the goal of increasing accuracy in the Fourier transforms, and on the other hand, allows for the selection of peaks of different frequencies. The ability to filter desired peaks is important for analyzing the power spectra of complex systems. The MC-SC-IVR approach allows us to solve a 19-dimensional test system and to resolve on-the-fly the power spectra of the formaldehyde molecule with very few classical trajectories. PMID:22149780
14 CFR 142.9 - Deviations or waivers.
Code of Federal Regulations, 2014 CFR
2014-01-01
... OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.9 Deviations or waivers. (a) The Administrator may issue deviations or waivers from any of the requirements of this part. (b) A training center...) That the deviation or waiver will not adversely affect the quality of instruction or evaluation....
A Visual Model for the Variance and Standard Deviation
ERIC Educational Resources Information Center
Orris, J. B.
2011-01-01
This paper shows how the variance and standard deviation can be represented graphically by looking at each squared deviation as a graphical object--in particular, as a square. A series of displays show how the standard deviation is the size of the average square.
7 CFR 400.204 - Notification of deviation from standards.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 6 2010-01-01 2010-01-01 false Notification of deviation from standards. 400.204... Contract-Standards for Approval § 400.204 Notification of deviation from standards. A Contractor shall advise the Corporation immediately if the Contractor deviates from the requirements of these...
Thermodynamic Lower Bounds of Deviation from Instantaneous Canonical State
NASA Astrophysics Data System (ADS)
Monnai, Takaaki
2016-04-01
We address the issue of the characterization of the nonequilibrium states for the time-dependent processes of a system interacting with a large reservoir, which is initially prepared in an equilibrium state. During the time evolution, we apply an external force to the system so that the actual density matrix is quantitatively different from the canonical state specified by the time-dependent system Hamiltonian. To express how the external forcing causes the deviation from equilibrium, we give a class of thermodynamic expressions for the lower bounds of the distance between the actual nonequilibrium state and the corresponding canonical state. The lower bounds are thermodynamically expressed only in terms of the strength of the forcing and its consequent entropy production rate.
Abuelo, D
1987-01-01
The author discusses the basic principles of genetics, including the classification of genetic disorders and a consideration of the rules and mechanisms of inheritance. The most common pitfalls in clinical genetic diagnosis are described, with emphasis on the problem of the negative or misleading family history.
ERIC Educational Resources Information Center
Siyanova-Chanturia, Anna; Martinez, Ron
2015-01-01
John Sinclair's Idiom Principle famously posited that most texts are largely composed of multi-word expressions that "constitute single choices" in the mental lexicon. At the time that assertion was made, little actual psycholinguistic evidence existed in support of that holistic, "single choice," view of formulaic language. In…
Middlemiss, Derek S. E-mail: R.J.Deeth@warwick.ac.uk; Deeth, Robert J. E-mail: R.J.Deeth@warwick.ac.uk
2014-04-14
The dielectric response of spin-crossover (SCO) materials is a key property facilitating their use in next-generation information processing technologies. Solid state hybrid density functional theory calculations show that the temperature-induced and strongly hysteretic SCO transition in the Cs{sup +}Fe{sup 2+}[Cr{sup 3+}(CN{sup −}){sub 6}] Prussian blue analogue (PBA) is associated with a large change (Δ) in both the static, Δε{sup 0}(HS − LS), and high frequency, Δε{sup ∞}(HS − LS) dielectric constants. The SCO-induced variation in CsFe[Cr(CN){sub 6}] is significantly greater than the experimental Δε values observed previously in other SCO materials. The phonon contribution, Δε{sup phon}(HS − LS), determined within a lattice dynamics approach, dominates over the clamped nuclei term, Δε{sup ∞}(HS − LS), and is in turn dominated by the low-frequency translational motions of Cs{sup +} cations within the cubic voids of the Fe[Cr(CN){sub 6}]{sup −} framework. The Cs{sup +} translational modes couple strongly to the large unit cell volume change occurring through the SCO transition. PBAs and associated metal-organic frameworks emerge as a potentially fruitful class of materials in which to search for SCO transitions associated with large changes in dielectric response and other macroscopic properties.
NASA Astrophysics Data System (ADS)
Middlemiss, Derek S.; Deeth, Robert J.
2014-04-01
The dielectric response of spin-crossover (SCO) materials is a key property facilitating their use in next-generation information processing technologies. Solid state hybrid density functional theory calculations show that the temperature-induced and strongly hysteretic SCO transition in the Cs+Fe2+[Cr3+(CN-)6] Prussian blue analogue (PBA) is associated with a large change (Δ) in both the static, Δɛ0(HS - LS), and high frequency, Δɛ∞(HS - LS) dielectric constants. The SCO-induced variation in CsFe[Cr(CN)6] is significantly greater than the experimental Δɛ values observed previously in other SCO materials. The phonon contribution, Δɛphon(HS - LS), determined within a lattice dynamics approach, dominates over the clamped nuclei term, Δɛ∞(HS - LS), and is in turn dominated by the low-frequency translational motions of Cs+ cations within the cubic voids of the Fe[Cr(CN)6]- framework. The Cs+ translational modes couple strongly to the large unit cell volume change occurring through the SCO transition. PBAs and associated metal-organic frameworks emerge as a potentially fruitful class of materials in which to search for SCO transitions associated with large changes in dielectric response and other macroscopic properties.
The response to prism deviations in human infants.
Riddell, P M; Horwood, A M; Houston, S M; Turner, J E
1999-09-23
Previous research has suggested that infants are unable to make a corrective eye movement in response to a small base-out prism placed in front of one eye before 14-16 weeks [1]. Three hypotheses have been proposed to explain this early inability, and each of these makes different predictions for the time of onset of a response to a larger prism. The first proposes that infants have a 'degraded sensory capacity' and so require a larger retinal disparity (difference in the position of the image on the retina of each eye) to stimulate disparity detectors [2]. This predicts that infants might respond at an earlier age than previously reported [1] when tested using a larger prism. The second hypothesis proposes that infants learn to respond to larger retinal disparities through practice with small disparities [3]. According to this theory, using a larger prism will not result in developmentally earlier responses, and may even delay the response. The third hypothesis proposes that the ability to respond to prismatic deviation depends on maturational factors indicated by the onset of stereopsis (the ability to detect depth in an image on the basis of retinal disparity cues only) [4] [5], predicting that the size of the prism is irrelevant. To differentiate between these hypotheses, we tested 192 infants ranging from 2 to 52 weeks of age using a larger prism. Results showed that 63% of infants of 5-8 weeks of age produced a corrective eye movement in response to placement of a prism in front of the eye when in the dark. Both the percentage of infants who produced a response, and the speed of the response, increased with age. These results suggest that infants can make corrective eye movements in response to large prismatic deviations before 14-16 weeks of age. This, in combination with other recent results [6], discounts previous hypotheses.
Constraints on deviations from ΛCDM within Horndeski gravity
NASA Astrophysics Data System (ADS)
Bellini, Emilio; Cuesta, Antonio J.; Jimenez, Raul; Verde, Licia
2016-02-01
Recent anomalies found in cosmological datasets such as the low multipoles of the Cosmic Microwave Background or the low redshift amplitude and growth of clustering measured by e.g., abundance of galaxy clusters and redshift space distortions in galaxy surveys, have motivated explorations of models beyond standard ΛCDM. Of particular interest are models where general relativity (GR) is modified on large cosmological scales. Here we consider deviations from ΛCDM+GR within the context of Horndeski gravity, which is the most general theory of gravity with second derivatives in the equations of motion. We adopt a parametrization in which the four additional Horndeski functions of time αi(t) are proportional to the cosmological density of dark energy ΩDE(t). Constraints on this extended parameter space using a suite of state-of-the art cosmological observations are presented for the first time. Although the theory is able to accommodate the low multipoles of the Cosmic Microwave Background and the low amplitude of fluctuations from redshift space distortions, we find no significant tension with ΛCDM+GR when performing a global fit to recent cosmological data and thus there is no evidence against ΛCDM+GR from an analysis of the value of the Bayesian evidence ratio of the modified gravity models with respect to ΛCDM, despite introducing extra parameters. The posterior distribution of these extra parameters that we derive return strong constraints on any possible deviations from ΛCDM+GR in the context of Horndeski gravity. We illustrate how our results can be applied to a more general frameworks of modified gravity models.
NASA Technical Reports Server (NTRS)
Sato, Toru
1989-01-01
Discussed here is a kind of radar called atmospheric radar, which has as its target clear air echoes from the earth's atmosphere produced by fluctuations of the atmospheric index of refraction. Topics reviewed include the vertical structure of the atmosphere, the radio refractive index and its fluctuations, the radar equation (a relation between transmitted and received power), radar equations for distributed targets and spectral echoes, near field correction, pulsed waveforms, the Doppler principle, and velocity field measurements.
Influence of altitude on aero-optic imaging deviation.
Xu, Liang; Cai, Yuanli
2011-06-20
Aero-optic imaging deviation is a kind of aero-optic effect. It characterizes the image position displacement on an imaging plane. This paper studies the influence of altitude on aero-optic imaging deviation. The Reynolds-averaged Navier-Stokes solver provided in FLUENT was used for flow computations. The Runge-Kutta method based ray tracing was adopted for optics calculations. The orthogonal array was brought in for the experiment arrangement. Four representative suites of imaging deviations and imaging deviation slopes were obtained in the altitude range of 10-60 km. The results show that as altitude increases, the imaging deviation decreases, and the imaging deviation slope approaches zero from a negative value. PMID:21691360
Branching ratio deviations from statistical behavior in core photoionization
NASA Astrophysics Data System (ADS)
Di Tommaso, Devis; Decleva, Piero
2005-08-01
Accurate calculations of carbon 1s photoionization cross sections have been performed at the density functional level with the B-spline linear combination of atomic orbitals approach. The molecules considered are FCCH, FCCCH3, FCCCN, F2CCH2, CF3COOCH2CH3, and C3H5O. The variation of the branching ratios relative to inequivalent C 1s ionizations have been evaluated from threshold to about 100 eV photoelectron kinetic energy. Large deviations from the statistical ratios are observed at low energies, which remain often significant several tens of eV above threshold. The importance of taking into account core branching ratios for peak deconvolution and quantitative analysis, as well as an additional tool for structural information, is pointed out. Strong shape resonant effects are found to largely cancel in branching ratios. Their nature and variation along the series is analyzed in the framework of excitations into σ* valence orbitals.
Staphylococcus aureus vaccines: Deviating from the carol.
Missiakas, Dominique; Schneewind, Olaf
2016-08-22
Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is associated with failure of antibiotic therapy and elevated mortality. Here we review polysaccharide-conjugate and subunit vaccines that were designed to prevent S. aureus infection in patients at risk of bacteremia or surgical wound infection but failed to reach their clinical endpoints. We also discuss vaccines with ongoing trials for combinations of polysaccharide-conjugates and subunits. S. aureus colonization and invasive disease are not associated with the development of protective immune responses, which is attributable to a large spectrum of immune evasion factors. Two evasive strategies, assembly of protective fibrin shields via coagulases and protein A-mediated B cell superantigen activity, are discussed as possible vaccine targets. Although correlates for protective immunity are not yet known, opsonophagocytic killing of staphylococci by phagocytic cells offers opportunities to establish such criteria. PMID:27526714
NASA Astrophysics Data System (ADS)
Oladyshkin, S.; Schroeder, P.; Class, H.; Nowak, W.
2013-12-01
Predicting underground carbon dioxide (CO2) storage represents a challenging problem in a complex dynamic system. Due to lacking information about reservoir parameters, quantification of uncertainties may become the dominant question in risk assessment. Calibration on past observed data from pilot-scale test injection can improve the predictive power of the involved geological, flow, and transport models. The current work performs history matching to pressure time series from a pilot storage site operated in Europe, maintained during an injection period. Simulation of compressible two-phase flow and transport (CO2/brine) in the considered site is computationally very demanding, requiring about 12 days of CPU time for an individual model run. For that reason, brute-force approaches for calibration are not feasible. In the current work, we explore an advanced framework for history matching based on the arbitrary polynomial chaos expansion (aPC) and strict Bayesian principles. The aPC [1] offers a drastic but accurate stochastic model reduction. Unlike many previous chaos expansions, it can handle arbitrary probability distribution shapes of uncertain parameters, and can therefore handle directly the statistical information appearing during the matching procedure. We capture the dependence of model output on these multipliers with the expansion-based reduced model. In our study we keep the spatial heterogeneity suggested by geophysical methods, but consider uncertainty in the magnitude of permeability trough zone-wise permeability multipliers. Next combined the aPC with Bootstrap filtering (a brute-force but fully accurate Bayesian updating mechanism) in order to perform the matching. In comparison to (Ensemble) Kalman Filters, our method accounts for higher-order statistical moments and for the non-linearity of both the forward model and the inversion, and thus allows a rigorous quantification of calibrated model uncertainty. The usually high computational costs of
Sure, Rebecca; Brandenburg, Jan Gerit; Grimme, Stefan
2016-04-01
In quantum chemical computations the combination of Hartree-Fock or a density functional theory (DFT) approximation with relatively small atomic orbital basis sets of double-zeta quality is still widely used, for example, in the popular B3LYP/6-31G* approach. In this Review, we critically analyze the two main sources of error in such computations, that is, the basis set superposition error on the one hand and the missing London dispersion interactions on the other. We review various strategies to correct those errors and present exemplary calculations on mainly noncovalently bound systems of widely varying size. Energies and geometries of small dimers, large supramolecular complexes, and molecular crystals are covered. We conclude that it is not justified to rely on fortunate error compensation, as the main inconsistencies can be cured by modern correction schemes which clearly outperform the plain mean-field methods. PMID:27308221
Sure, Rebecca; Brandenburg, Jan Gerit; Grimme, Stefan
2016-04-01
In quantum chemical computations the combination of Hartree-Fock or a density functional theory (DFT) approximation with relatively small atomic orbital basis sets of double-zeta quality is still widely used, for example, in the popular B3LYP/6-31G* approach. In this Review, we critically analyze the two main sources of error in such computations, that is, the basis set superposition error on the one hand and the missing London dispersion interactions on the other. We review various strategies to correct those errors and present exemplary calculations on mainly noncovalently bound systems of widely varying size. Energies and geometries of small dimers, large supramolecular complexes, and molecular crystals are covered. We conclude that it is not justified to rely on fortunate error compensation, as the main inconsistencies can be cured by modern correction schemes which clearly outperform the plain mean-field methods.
Sure, Rebecca; Brandenburg, Jan Gerit
2015-01-01
Abstract In quantum chemical computations the combination of Hartree–Fock or a density functional theory (DFT) approximation with relatively small atomic orbital basis sets of double‐zeta quality is still widely used, for example, in the popular B3LYP/6‐31G* approach. In this Review, we critically analyze the two main sources of error in such computations, that is, the basis set superposition error on the one hand and the missing London dispersion interactions on the other. We review various strategies to correct those errors and present exemplary calculations on mainly noncovalently bound systems of widely varying size. Energies and geometries of small dimers, large supramolecular complexes, and molecular crystals are covered. We conclude that it is not justified to rely on fortunate error compensation, as the main inconsistencies can be cured by modern correction schemes which clearly outperform the plain mean‐field methods. PMID:27308221
Cechner, R L
1983-04-01
We report the strategies for design and implementation of a system of compatible mini- and microcomputers intended to improve efficiency of data handling and research in several clinical and academic divisions of a large university hospital department of Pathology. A dedicated, preprogrammed, multiuser, word processing computer and small standalone word processing stations connected to a general purpose minicomputer, using standard network protocols for communication, permit virtually error-free movement of data between computers doing functionally distinct tasks of word processing, data base management, and general scientific computing. User programming is minimized and is done in a simple, well-known, high-level language. We show that cost, thruput, speed, document volume, document size, revision cycle frequency, data base size, and frequency of use are important design criteria and that existing staff can be trained easily to operate the systems.
Nonlinear Elastic Effects on the Energy Flux Deviation of Ultrasonic Waves in GR/EP Composites
NASA Technical Reports Server (NTRS)
Prosser, William H.; Kriz, R. D.; Fitting, Dale W.
1992-01-01
In isotropic materials, the direction of the energy flux (energy per unit time per unit area) of an ultrasonic plane wave is always along the same direction as the normal to the wave front. In anisotropic materials, however, this is true only along symmetry directions. Along other directions, the energy flux of the wave deviates from the intended direction of propagation. This phenomenon is known as energy flux deviation and is illustrated. The direction of the energy flux is dependent on the elastic coefficients of the material. This effect has been demonstrated in many anisotropic crystalline materials. In transparent quartz crystals, Schlieren photographs have been obtained which allow visualization of the ultrasonic waves and the energy flux deviation. The energy flux deviation in graphite/epoxy (gr/ep) composite materials can be quite large because of their high anisotropy. The flux deviation angle has been calculated for unidirectional gr/ep composites as a function of both fiber orientation and fiber volume content. Experimental measurements have also been made in unidirectional composites. It has been further demonstrated that changes in composite materials which alter the elastic properties such as moisture absorption by the matrix or fiber degradation, can be detected nondestructively by measurements of the energy flux shift. In this research, the effects of nonlinear elasticity on energy flux deviation in unidirectional gr/ep composites were studied. Because of elastic nonlinearity, the angle of the energy flux deviation was shown to be a function of applied stress. This shift in flux deviation was modeled using acoustoelastic theory and the previously measured second and third order elastic stiffness coefficients for T300/5208 gr/ep. Two conditions of applied uniaxial stress were considered. In the first case, the direction of applied uniaxial stress was along the fiber axis (x3) while in the second case it was perpendicular to the fiber axis along the
21 CFR 211.100 - Written procedures; deviations.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Written procedures; deviations. 211.100 Section... Process Controls § 211.100 Written procedures; deviations. (a) There shall be written procedures for... in this subpart. These written procedures, including any changes, shall be drafted, reviewed,...
21 CFR 211.100 - Written procedures; deviations.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Written procedures; deviations. 211.100 Section... Process Controls § 211.100 Written procedures; deviations. (a) There shall be written procedures for... in this subpart. These written procedures, including any changes, shall be drafted, reviewed,...
Refraction in Terms of the Deviation of the Light.
ERIC Educational Resources Information Center
Goldberg, Fred M.
1985-01-01
Discusses refraction in terms of the deviation of light. Points out that in physics courses where very little mathematics is used, it might be more suitable to describe refraction entirely in terms of the deviation, rather than by introducing Snell's law. (DH)
33 CFR 164.51 - Deviations from rules: Emergency.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.51 Deviations from...
33 CFR 164.51 - Deviations from rules: Emergency.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Deviations from rules: Emergency. 164.51 Section 164.51 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.51 Deviations from...
41 CFR 101-42.002 - Requests for deviations.
Code of Federal Regulations, 2010 CFR
2010-07-01
... DISPOSAL OF HAZARDOUS MATERIALS AND CERTAIN CATEGORIES OF PROPERTY § 101-42.002 Requests for deviations... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Requests for deviations. 101-42.002 Section 101-42.002 Public Contracts and Property Management Federal Property...
38 CFR 36.4304 - Deviations; changes of identity.
Code of Federal Regulations, 2011 CFR
2011-07-01
... identity. 36.4304 Section 36.4304 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Deviations; changes of identity. A deviation of more than 5 percent between the estimates upon which a... change in the identity of the property upon which the original appraisal was based, will invalidate...
38 CFR 36.4304 - Deviations; changes of identity.
Code of Federal Regulations, 2013 CFR
2013-07-01
... identity. 36.4304 Section 36.4304 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Deviations; changes of identity. A deviation of more than 5 percent between the estimates upon which a... change in the identity of the property upon which the original appraisal was based, will invalidate...
38 CFR 36.4304 - Deviations; changes of identity.
Code of Federal Regulations, 2014 CFR
2014-07-01
... identity. 36.4304 Section 36.4304 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Deviations; changes of identity. A deviation of more than 5 percent between the estimates upon which a... change in the identity of the property upon which the original appraisal was based, will invalidate...
38 CFR 36.4304 - Deviations; changes of identity.
Code of Federal Regulations, 2010 CFR
2010-07-01
... identity. 36.4304 Section 36.4304 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Deviations; changes of identity. A deviation of more than 5 percent between the estimates upon which a... change in the identity of the property upon which the original appraisal was based, will invalidate...
48 CFR 570.704 - Deviations to provisions and clauses.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Deviations to provisions and clauses. 570.704 Section 570.704 Federal Acquisition Regulations System GENERAL SERVICES... contracting officer also needs an approved deviation to modify the language of a provision or clause...
48 CFR 2801.470 - Requests for class deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... deviations. 2801.470 Section 2801.470 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General DEPARTMENT OF JUSTICE ACQUISITION REGULATIONS SYSTEM Deviations From the FAR and JAR 2801.470 Requests for... to the PE. Such requests will be signed by the Bureau Procurement Chief (BPC). Requests for...
33 CFR 161.5 - Deviations from the rules.
Code of Federal Regulations, 2010 CFR
2010-07-01
... information, such a deviation provides a level of safety equivalent to that provided by the required measure... by the required measure or is a maneuver considered necessary for safe navigation under the... alternative to the required measure. (b) Requests to deviate from any provision in this part due...
10 CFR 1017.5 - Requesting a deviation.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 4 2012-01-01 2012-01-01 false Requesting a deviation. 1017.5 Section 1017.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR... create a potential or real vulnerability); or (3) An exception (i.e., an approved deviation from...
10 CFR 1017.5 - Requesting a deviation.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Requesting a deviation. 1017.5 Section 1017.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR... create a potential or real vulnerability); or (3) An exception (i.e., an approved deviation from...
10 CFR 1017.5 - Requesting a deviation.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 4 2013-01-01 2013-01-01 false Requesting a deviation. 1017.5 Section 1017.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR... create a potential or real vulnerability); or (3) An exception (i.e., an approved deviation from...
21 CFR 330.11 - NDA deviations from applicable monograph.
Code of Federal Regulations, 2011 CFR
2011-04-01
... (CONTINUED) DRUGS FOR HUMAN USE OVER-THE-COUNTER (OTC) HUMAN DRUGS WHICH ARE GENERALLY RECOGNIZED AS SAFE AND... new drug application requesting approval of an OTC drug deviating in any respect from a monograph that... 21 Food and Drugs 5 2011-04-01 2011-04-01 false NDA deviations from applicable monograph....
21 CFR 330.11 - NDA deviations from applicable monograph.
Code of Federal Regulations, 2010 CFR
2010-04-01
... (CONTINUED) DRUGS FOR HUMAN USE OVER-THE-COUNTER (OTC) HUMAN DRUGS WHICH ARE GENERALLY RECOGNIZED AS SAFE AND... new drug application requesting approval of an OTC drug deviating in any respect from a monograph that... 21 Food and Drugs 5 2010-04-01 2010-04-01 false NDA deviations from applicable monograph....
On Testing the Equivalence Principle with Extragalactic Bursts
NASA Astrophysics Data System (ADS)
Nusser, Adi
2016-04-01
An interesting test of Einstein’s equivalence principle (EEP) relies on the observed lag in the arrival times of photons emitted from extragalactic transient sources. Attributing the lag between photons of different energies to the gravitational potential of the Milky Way (MW), several authors derive new constraints on deviations from EEP. It is shown here that potential fluctuations from the large-scale structure are at least two orders of magnitude larger than the gravitational potential of the MW. Combined with the larger distances, for sources at redshift z≳ 0.5 the rms of the contribution from these fluctuations exceeds the MW by more than four orders of magnitude. We provide actual constraints for several objects based on a statistical calculation of the large-scale fluctuations in the standard ΛCDM cosmological model.
Drastic deviations from stoichiometry transfer during pulsed laser deposition
NASA Astrophysics Data System (ADS)
Dittrich, Arne; Eberl, Christian; Schlenkrich, Susanne; Schlenkrich, Felix; Döring, Florian; Krebs, Hans-Ulrich
2016-04-01
In common, one of the most characteristic properties of pulsed laser deposition is the stoichiometry transfer between target and substrate, which has been used heavily for many complex systems. In this paper we show that it is yet possible to obtain drastic deviations from stoichiometry transfer in a binary system by just varying the fluence during laser deposition. In the W-Cu system, the W concentration of films grown from a composite W60Cu40 target (60 wt% W) was indeed continuously changed over an unprecedented large range of 0-70 wt% W. Close to the deposition threshold, pure Cu films are formed due to the much higher vapor pressure of Cu. At higher laser fluences, more and more W-rich W-Cu alloy samples are obtained, since ion implantation and intermixing processes occur. These alloys can reach W contents even higher than that of the target because of enhanced resputtering and reflection of the lighter Cu atoms at the film surface. Stoichiometric films with 60 wt% of W are only obtained at laser fluences around 2.7 J/cm2, when the strong Cu evaporation from the target and reflection and resputtering effects of Cu at the film surface are in balance.
Identification of characteristic model-observation deviations for coupled data assimilation
NASA Astrophysics Data System (ADS)
Geppert, Gernot; Ament, Felix
2016-04-01
Exchange fluxes of water and energy between the land surface and the atmosphere lead to the propagation of errors from one model component to the other. Data assimilation can correct such errors in two ways, either by correcting the observed state directly or by changing the state that caused the exchange fluxes. The land surface, for example, strongly determines the temperature in the atmospheric boundary layer. The assimilation of boundary layer temperature can then correct the model's temperature directly. Or the assimilation of boundary layer temperature can act on the model's land surface state. A coupled data assimilation system should exploit these links and enable the second type of correction across model components. Data assimilation relies on instantaneous deviations between model forecasts and observations. Such instantaneous deviations are often hard to relate to errors in specific model components. Therefore, model verification builds on more sophisticated statistics such as long-term biases, gradients, phase shifts, or conditional differences that yield characteristic differences between model forecasts and observations. Compared to the instantaneous deviations in data assimilation, the characteristic deviations in model verification are more closely linked to errors in specific model components. Consequently, such characteristic deviations can potentially be used for data assimilation across model components where instantaneous deviations are not sufficiently informative. As a first step towards data assimilation with characteristic deviations (here named fingerprints), we use ensembles of simulations with the Icosahedral Non-hydrostatic (ICON) model to identify applicable statistics of observable variables. We run ICON in a large eddy simulation configuration on a small, limited domain and systematically perturb soil and land-surface parameters and states to produce the ensembles. Subsequently, we test statistics of boundary layer observables to
Robust estimation of standard deviation using ordered samples
Beedgen, R.
1982-07-01
A robust estimate for the standard deviation of a normal distribution is developed. We choose the contaminated normal distribution as our outlier model and demonstrate the method with two examples representing data from international interlaboratory experiments.
33 CFR 151.2055 - Deviation from planned voyage.
Code of Federal Regulations, 2012 CFR
2012-07-01
... United States § 151.2055 Deviation from planned voyage. As long as ballast water exchange (BWE) is an... (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL...
33 CFR 151.2055 - Deviation from planned voyage.
Code of Federal Regulations, 2013 CFR
2013-07-01
... United States § 151.2055 Deviation from planned voyage. As long as ballast water exchange (BWE) is an... (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL...
33 CFR 151.2055 - Deviation from planned voyage.
Code of Federal Regulations, 2014 CFR
2014-07-01
... United States § 151.2055 Deviation from planned voyage. As long as ballast water exchange (BWE) is an... (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL...
A Note on Standard Deviation and Standard Error
ERIC Educational Resources Information Center
Hassani, Hossein; Ghodsi, Mansoureh; Howell, Gareth
2010-01-01
Many students confuse the standard deviation and standard error of the mean and are unsure which, if either, to use in presenting data. In this article, we endeavour to address these questions and cover some related ambiguities about these quantities.
A hybrid method with deviational particles for spatial inhomogeneous plasma
NASA Astrophysics Data System (ADS)
Yan, Bokai
2016-03-01
In this work we propose a Hybrid method with Deviational Particles (HDP) for a plasma modeled by the inhomogeneous Vlasov-Poisson-Landau system. We split the distribution into a Maxwellian part evolved by a grid based fluid solver and a deviation part simulated by numerical particles. These particles, named deviational particles, could be both positive and negative. We combine the Monte Carlo method proposed in [31], a Particle in Cell method and a Macro-Micro decomposition method [3] to design an efficient hybrid method. Furthermore, coarse particles are employed to accelerate the simulation. A particle resampling technique on both deviational particles and coarse particles is also investigated and improved. This method is applicable in all regimes and significantly more efficient compared to a PIC-DSMC method near the fluid regime.
Spin-geodesic deviations in the Schwarzschild spacetime
NASA Astrophysics Data System (ADS)
Bini, Donato; Geralico, Andrea; Jantzen, Robert T.
2011-04-01
The deviation of the path of a spinning particle from a circular geodesic in the Schwarzschild spacetime is studied by an extension of the idea of geodesic deviation. Within the Mathisson-Papapetrou-Dixon model and assuming the spin parameter to be sufficiently small so that it makes sense to linearize the equations of motion in the spin variables as well as in the geodesic deviation, the spin-curvature force adds an additional driving term to the second order system of linear ordinary differential equations satisfied by nearby geodesics. Choosing initial conditions for geodesic motion leads to solutions for which the deviations are entirely due to the spin-curvature force, and one finds that the spinning particle position for a given fixed total spin oscillates roughly within an ellipse in the plane perpendicular to the motion, while the azimuthal motion undergoes similar oscillations plus an additional secular drift which varies with spin orientation.
Comparison of estimators of standard deviation for hydrologic time series.
Tasker, Gary D.; Gilroy, E.J.
1982-01-01
Unbiasing factors as a function of serial correlation, rho, and sample size, n for the sample standard deviation of a lag one autoregressive model were generated by random number simulation. Monte Carlo experiments were used to compare the performance of several alternative methods for estimating the standard deviation sigma of a lag one autoregressive model in terms of bias, root mean square error, probability of underestimation, and expected opportunity design loss. -from Authors
Nasal Septal Deviations: A Systematic Review of Classification Systems
Teixeira, Jeffrey; Certal, Victor; Chang, Edward T.; Camacho, Macario
2016-01-01
Objective. To systematically review the international literature for internal nasal septal deviation classification systems and summarize them for clinical and research purposes. Data Sources. Four databases (including PubMed/MEDLINE) were systematically searched through December 16, 2015. Methods. Systematic review, adhering to PRISMA. Results. After removal of duplicates, this study screened 952 articles for relevance. A final comprehensive review of 50 articles identified that 15 of these articles met the eligibility criteria. The classification systems defined in these articles included C-shaped, S-shaped, reverse C-shaped, and reverse S-shaped descriptions of the septal deviation in both the cephalocaudal and anteroposterior dimensions. Additional studies reported use of computed tomography and categorized deviation based on predefined locations. Three studies graded the severity of septal deviations based on the amount of deflection. The systems defined in the literature also included an evaluation of nasal septal spurs and perforations. Conclusion. This systematic review ascertained that the majority of the currently published classification systems for internal nasal septal deviations can be summarized by C-shaped or reverse C-shaped, as well as S-shaped or reverse S-shaped deviations in the anteroposterior and cephalocaudal dimensions. For imaging studies, predefined points have been defined along the septum. Common terminology can facilitate future research. PMID:26933510
Principles of Glacier Mechanics
NASA Astrophysics Data System (ADS)
Waddington, Edwin D.
Glaciers are awesome in size and move at a majestic pace, and they frequently occupy spectacular mountainous terrain. Naturally, many Earth scientists are attracted to glaciers. Some of us are even fortunate enough to make a career of studying glacier flow. Many others work on the large, flat polar ice sheets where there is no scenery. As a leader of one of the foremost research projects now studying the flow of mountain glaciers (Storglaciaren, Norway), Roger Hooke is well qualified to describe the principles of glacier mechanics. Principles of Glacier Mechanics is written for upper-level undergraduate students and graduate students with an interest in glaciers and the landforms that glaciers produce. While most of the examples in the text are drawn from valley glacier studies, much of the material is also relevant to “glacier flatland” on the polar ice sheets.
NASA Technical Reports Server (NTRS)
Prosser, William H.; Kriz, R. D.; Fitting, Dale W.
1990-01-01
Ultrasonic waves suffer energy flux deviation in graphite/epoxy because of the large anisotropy. The angle of deviation is a function of the elastic coefficients. For nonlinear solids, these coefficients and thus the angle of deviation is a function of stress. Acoustoelastic theory was used to model the effect of stress on flux deviation for unidirectional T300/5208 using previously measured elastic coefficients. Computations were made for uniaxial stress along the x3 axis fiber axis) and the x1 axis for waves propagating in the x1x3 plane. These results predict a shift as large as three degrees for the quasi-transverse wave. The shift in energy flux offers new nondestructive technique of evaluating stress in composites.
Acoustic Anisotropy Measurement and Interpretation in Deviated Wells
NASA Astrophysics Data System (ADS)
Tang, X.; Patterson, D.
2005-05-01
A current trend in petroleum exploration and production is that more and more deviated/horizontal wells are drilled, especially in deep water reservoirs like Gulf of Mexico. The issue of anisotropy is particularly important for deviated wells penetrating the soft sedimentary rocks of the reservoirs. In sedimentary formations, shales can be highly anisotropic due to mineral alignment, and sands can also be anisotropic due to their sensitivity to formation stresses. Many acoustic anisotropy measurements using cross-dipole tools have been made in deviated wells. However, interpreting the acoustic anisotropy data can be quite complicated, especially in the presence of strong anisotropy. In a deviated well, the well trajectory is neither perpendicular to, nor parallel with, the formation bedding planes. Consequently, the measured anisotropy is not the true formation anisotropy, but an apparent anisotropy at a given well deviation. Besides, several anisotropy parameters (e.g., Thomsen parameters) are needed to characterize the formation anisotropy while the cross-dipole measures only one of them. Nevertheless, the variation of the anisotropy and its associated azimuth relative to the well trajectory contains the information about the anisotropy parameters. By analyzing the anisotropy data in conjunction with the well configuration, we can characterize the relationship among the anisotropy parameters. By combining the data with lithology, we can also distinguish stress-induced anisotropy from other sources of anisotropy. The result is an improved characterization of formation anisotropy and its geological environment.
Mean-deviation analysis in the theory of choice.
Grechuk, Bogdan; Molyboha, Anton; Zabarankin, Michael
2012-08-01
Mean-deviation analysis, along with the existing theories of coherent risk measures and dual utility, is examined in the context of the theory of choice under uncertainty, which studies rational preference relations for random outcomes based on different sets of axioms such as transitivity, monotonicity, continuity, etc. An axiomatic foundation of the theory of coherent risk measures is obtained as a relaxation of the axioms of the dual utility theory, and a further relaxation of the axioms are shown to lead to the mean-deviation analysis. Paradoxes arising from the sets of axioms corresponding to these theories and their possible resolutions are discussed, and application of the mean-deviation analysis to optimal risk sharing and portfolio selection in the context of rational choice is considered.
High septal osteotomy in rhinoplasty for the deviated nose.
Jameson, John J; Perry, Adam D; Ritter, Edmond F
2006-01-01
When attempting to straighten a patient's healed, deviated bony nasal dorsum, deviation of the central structure (high dorsal septum and medial nasal bones) must be addressed following the completion of medial and lateral osteotomies. When hump resection is not performed, blunt fracture (digitally or with forceps) of the deviated central structure is not a reliable method of mobilization, often leading to postoperative nasal drift. An intranasal osteotomy technique to mobilize the central structure of the nose is described, called "high septal osteotomy." Review of 25 cases suggests high septal osteotomy, supplemented as needed by resection of overlapping septal elements, can be performed safely and efficaciously, permitting stable midline reduction of the nasal pyramid. The technique is not advocated when hump resection is performed, as it is unnecessary and could destabilize the dorsum. Even aggressive maneuvers to mobilize the bony dorsum may fail if not performed properly with meticulous attention to completion of all osteotomies.
Deviation from Curie-Weiss behavior in relaxor ferroelectrics
NASA Astrophysics Data System (ADS)
Viehland, Dwight; Jang, S. J.; Cross, L. Eric; Wuttig, Manfred
1992-10-01
The deviation from Cure-Weiss behavior has been investigated in lead magnesium niobate relaxor ferroelectrics. At high temperatures, the susceptibility was found to follow the Curie-Weiss relationship. A Curie constant and temperature of 1.2×105 and 398 K, respectively, were obtained. With decreasing temperature the deviation was found to increase. It is proposed that this deviation arises due to short-range correlations between polar regions, and that these correlations at high temperatures are the precursor to a freezing of the polarization fluctuations into a glassy state. A local (glassy) order parameter was calculated from the susceptibility by analogy to spin glasses [D. Sherrington and S. Kirkpatrick, Phys. Rev. Lett. 35, 1972 (1975)]. These results are compared to the rms polarization [G. Burns and F. Dacol, Solid State Commun. 48, 853 (1983)] and to the measured remanent polarization. The frequency and field dependence has also been investigated.
Why historical east deviation experiments are so difficult to perform?
NASA Astrophysics Data System (ADS)
Darbois Texier, Baptiste; Cohen, Caroline; Quere, David; Clanet, Christophe
2012-11-01
From the 17th to the 19th century, a big deal was to prove Earth rotation existence. For this purpose, numerous experimental physicists from Borelli in 1668 to Reich in 1832 tried to measure an eastward deviation of a falling sphere. Reich performed 106 falling experiments on a 158.5 m deep mine pit. The mean eastward deviation of its experiments is 2.8 cm. This value corresponds exactly with the theoretical one predicted by Laplace and Gauss expression at Freiberg latitude where experiments were conducted. While Reich took extreme precautions to perform its experiments, the dispersion on its results is very important. Actually aerodynamic lift forces on a smooth sphere made its free fall non perfectly straight. We understand Reich's results dispersion considering fluctuating lift forces intensity on a smooth sphere at those Reynolds numbers (Re ~104 -105). This study provides a criterion above which we can distinguish between lift force and Coriolis deviation during a free fall experiment.
Spin-geodesic deviations in the Kerr spacetime
NASA Astrophysics Data System (ADS)
Bini, D.; Geralico, A.
2011-11-01
The dynamics of extended spinning bodies in the Kerr spacetime is investigated in the pole-dipole particle approximation and under the assumption that the spin-curvature force only slightly deviates the particle from a geodesic path. The spin parameter is thus assumed to be very small and the back reaction on the spacetime geometry neglected. This approach naturally leads to solve the Mathisson-Papapetrou-Dixon equations linearized in the spin variables as well as in the deviation vector, with the same initial conditions as for geodesic motion. General deviations from generic geodesic motion are studied, generalizing previous results limited to the very special case of an equatorial circular geodesic as the reference path.
NASA Technical Reports Server (NTRS)
2001-01-01
Cells cultured on Earth (left) typically settle quickly on the bottom of culture vessels due to gravity. In microgravity (right), cells remain suspended and aggregate to form three-dimensional tissue. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators.
Equivalence principles and electromagnetism
NASA Technical Reports Server (NTRS)
Ni, W.-T.
1977-01-01
The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.
Gulf Stream model. [which considers surface elevation deviations
NASA Technical Reports Server (NTRS)
1974-01-01
Surface elevation deviations in the Gulf Stream region off the eastern coast of the United States between Wallops Island, Virginia and Miami, Florida were investigated. The main causes of surface elevation deviations are geoid perturbations due to the continental shelf and the geostrophic adjustment of the density field due to the Gulf Stream. Quantitative surface elevation profiles were calculated based on geophysical measurements of gravity anomalies and hydrographic data. The results are presented graphically along with contemporaneous weather data. Comparisons are made between the profiles based on hydrographic data and a mean theoretical model. The theory of geostrophic flows including some classical Gulf Stream models is also presented briefly.
[Deviation index of eye and mouth on peripheral facial paralysis].
Li, Xue; Liao, Pin-Dong; Luo, Min; Zhu, Bin-Ye
2011-09-01
Differences of some points, levels and angles of the healthy and affected sides of patients with peripheral facial paralysis were picked out according to photographs. Through analysis of the index between the healthy and affected side of the patients and the difference between healthy people and patients, it is approved that those special points, levels and angles, which are called as deviation index of eye and mouth, can evaluate peripheral facial paralysis objectively and judge the degree of deviation. Therefore, it provides references for the diagnosis of facial paralysis and its degree judgement.
A study of course deviations during cross-country soaring
NASA Technical Reports Server (NTRS)
Sliwa, S. M.; Sliwa, D. J.
1979-01-01
Several models are developed for studying the impact of deviations from course during cross country soaring flights. Analyses are performed at the microstrategy and macrostrategy levels. Two types of lift sources are considered: concentrated thermals and thermal streets. The sensitivity of the optimum speed solutions to various model, piloting and performance parameters is evaluated. Guides are presented to provide the pilot with criterions for making in-flight decisions. In general, course deviations are warranted during weak lift conditions, but are less justifiable with moderate to strong lift conditions.
Strong deviations from jellium behavior in the valence electron dynamics of potassium
NASA Astrophysics Data System (ADS)
Huotari, Simo; Sternemann, Christian; Troparevsky, M. Claudia; Eguiluz, Adolfo G.; Volmer, Martin; Sternemann, Henning; Müller, Harald; Monaco, Giulio; Schülke, Winfried
2009-10-01
We present experimental and ab initio theoretical determination of the dynamics of valence electrons in potassium by investigating the dynamical structure factor at nonvanishing momentum transfers. The spectra show large deviations from a jellium-type behavior due to the presence of d -type states above the Fermi level. In particular, we identify two well-defined interband excitations that have a direct correspondence with the density of states above the Fermi level.
Bodnar, Richard J; Rotella, Francis M; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M; Azad, Raihana; Stellar, James R
2016-01-01
A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918
Bodnar, Richard J; Rotella, Francis M; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M; Azad, Raihana; Stellar, James R
2016-01-01
A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment.
Bodnar, Richard J.; Rotella, Francis M.; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M.; Azad, Raihana; Stellar, James R.
2016-01-01
A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918
An improved device for bioimpedance deviation measurements based on 4-electrode half bridge
NASA Astrophysics Data System (ADS)
Liu, Yang; Qiao, Xiaoyan; Li, Gang; Lin, Ling
2016-10-01
Researches on monitoring the body fluid changes have attracted much attention during recent years. Real-time bioimpedance deviation detection has good potential for evaluating body fluid changes. In this paper, an improved device based on the self-balancing half bridge and the 4-electrode technique is proposed, which is able to detect minor bioimpedance deviations. The 4-electrode technique is used to remove the interference from contact impedance. Furthermore, the automatic balancing half bridge is utilized to deduct the high-level static impedance baseline, and thus, the dynamic range is enlarged. Moreover, a digital lock-in algorithm based on oversampling improved the effective resolution of the system. Validation experiments show that the minimum bioimpedance deviation measured in the experiment can reach 1 Ω even when the bioimpedance baseline is 10 kΩ and the noise level is low. The system has advantages of high resolution, high magnification, large dynamic range, and good self-adaptability for bioimpedance deviation detection.
On the influence of airfoil deviations on the aerodynamic performance of wind turbine rotors
NASA Astrophysics Data System (ADS)
Winstroth, J.; Seume, J. R.
2016-09-01
The manufacture of large wind turbine rotor blades is a difficult task that still involves a certain degree of manual labor. Due to the complexity, airfoil deviations between the design airfoils and the manufactured blade are certain to arise. Presently, the understanding of the impact of manufacturing uncertainties on the aerodynamic performance is still incomplete. The present work analyzes the influence of a series of airfoil deviations likely to occur during manufacturing by means of Computational Fluid Dynamics and the aeroelastic code FAST. The average power production of the NREL 5MW wind turbine is used to evaluate the different airfoil deviations. Analyzed deviations include: Mold tilt towards the leading and trailing edge, thick bond lines, thick bond lines with cantilever correction, backward facing steps and airfoil waviness. The most severe influences are observed for mold tilt towards the leading and thick bond lines. By applying the cantilever correction, the influence of thick bond lines is almost compensated. Airfoil waviness is very dependent on amplitude height and the location along the surface of the airfoil. Increased influence is observed for backward facing steps, once they are high enough to trigger boundary layer transition close to the leading edge.
Velocity Structure Determination Through Seismic Waveform Modeling and Time Deviations
NASA Astrophysics Data System (ADS)
Savage, B.; Zhu, L.; Tan, Y.; Helmberger, D. V.
2001-12-01
Through the use of seismic waveforms recorded by TriNet, a dataset of earthquake focal mechanisms and deviations (time shifts) relative to a standard model facilitates the investigation of the crust and uppermost mantle of southern California. The CAP method of focal mechanism determination, in use by TriNet on a routine basis, provides time shifts for surface waves and Pnl arrivals independently relative to the reference model. These shifts serve as initial data for calibration of local and regional seismic paths. Time shifts from the CAP method are derived by splitting the Pnl section of the waveform, the first arriving Pn to just before the arrival of the S wave, from the much slower surface waves then cross-correlating the data with synthetic waveforms computed from a standard model. Surface waves interact with the entire crust, but the upper crust causes the greatest effect. Whereas, Pnl arrivals sample the deeper crust, upper mantle, and source region. This natural division separates the upper from lower crust for regional calibration and structural modeling and allows 3-D velocity maps to be created using the resulting time shifts. Further examination of Pnl and other arrivals which interact with the Moho illuminate the complex nature of this boundary. Initial attempts at using the first 10 seconds of the Pnl section to determine upper most mantle structure have proven insightful. Two large earthquakes north of southern California in Nevada and Mammoth Lakes, CA allow the creation of record sections from 200 to 600 km. As the paths swing from east to west across southern California, simple 1-D models turn into complex structure, dramatically changing the waveform character. Using finite difference models to explain the structure, we determine that a low velocity zone is present at the base of the crust and extends to 100 km in depth. Velocity variations of 5 percent of the mantle in combination with steeply sloping edges produces complex waveform variations
Osis, Sean T.; Hettinga, Blayne A.; Macdonald, Shari; Ferber, Reed
2016-01-01
In order to provide effective test-retest and pooling of information from clinical gait analyses, it is critical to ensure that the data produced are as reliable as possible. Furthermore, it has been shown that anatomical marker placement is the largest source of inter-examiner variance in gait analyses. However, the effects of specific, known deviations in marker placement on calculated kinematic variables are unclear, and there is currently no mechanism to provide location-based feedback regarding placement consistency. The current study addresses these disparities by: applying a simulation of marker placement deviations to a large (n = 411) database of runners; evaluating a recently published method of morphometric-based deviation detection; and pilot-testing a system of location-based feedback for marker placements. Anatomical markers from a standing neutral trial were moved virtually by up to 30 mm to simulate deviations. Kinematic variables during running were then calculated using the original, and altered static trials. Results indicate that transverse plane angles at the knee and ankle are most sensitive to deviations in marker placement (7.59 degrees of change for every 10 mm of marker error), followed by frontal plane knee angles (5.17 degrees for every 10 mm). Evaluation of the deviation detection method demonstrated accuracies of up to 82% in classifying placements as deviant. Finally, pilot testing of a new methodology for providing location-based feedback demonstrated reductions of up to 80% in the deviation of outcome kinematics. PMID:26765846
40 CFR 63.1965 - What is a deviation?
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 13 2012-07-01 2012-07-01 false What is a deviation? 63.1965 Section 63.1965 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air...
21 CFR 114.89 - Deviations from scheduled processes.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Deviations from scheduled processes. 114.89 Section 114.89 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.89...
21 CFR 114.89 - Deviations from scheduled processes.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Deviations from scheduled processes. 114.89 Section 114.89 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.89...
21 CFR 114.89 - Deviations from scheduled processes.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Deviations from scheduled processes. 114.89 Section 114.89 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.89...
21 CFR 114.89 - Deviations from scheduled processes.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Deviations from scheduled processes. 114.89 Section 114.89 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.89...
Analysis of Finger Pulse by Standard Deviation Using Moving Average
NASA Astrophysics Data System (ADS)
Asakawa, Takashi; Nishihara, Kazue; Yoshidome, Tadashi
We propose a method of analyzing a finger pulse by standard deviation using moving average for measuring mental load. Frequency analysis, Lorentz plot and Lyapnov exponent have been carried out to present measurement. However, this technique is analyzable in a shorter time than the existing technique.
41 CFR 109-1.110-50 - Deviation procedures.
Code of Federal Regulations, 2013 CFR
2013-07-01
...) shall be forwarded with supporting documentation by the Organizational Property Management Officer (OPMO... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Deviation procedures. 109-1.110-50 Section 109-1.110-50 Public Contracts and Property Management Federal Property...
41 CFR 109-1.110-50 - Deviation procedures.
Code of Federal Regulations, 2012 CFR
2012-01-01
...) shall be forwarded with supporting documentation by the Organizational Property Management Officer (OPMO... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Deviation procedures. 109-1.110-50 Section 109-1.110-50 Public Contracts and Property Management Federal Property...
41 CFR 109-1.110-50 - Deviation procedures.
Code of Federal Regulations, 2011 CFR
2011-01-01
...) shall be forwarded with supporting documentation by the Organizational Property Management Officer (OPMO... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Deviation procedures. 109-1.110-50 Section 109-1.110-50 Public Contracts and Property Management Federal Property...
45 CFR 63.19 - Budget revisions and minor deviations.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Budget revisions and minor deviations. 63.19 Section 63.19 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions §...
Syntactic and Lexical Deviations in Children's Written Sentences.
ERIC Educational Resources Information Center
Golub, Lester S.
Compositions based on a picture as stimulus and written by fourth and sixth graders were studied for syntactic and lexical deviations. From the corpus of data, eight interpretations were made: (1) comma fault, sentence sense, and coordinating conjunctions were the most frequent syntactic problems encountered--all could be eliminated by oral…
The Effect of Type of Punishment on Resistance to Deviation.
ERIC Educational Resources Information Center
LaVoie, Joseph C.
The comparative effectiveness of an aversive stimulus, withholding of resources, withdrawal of love and reasoning, when used alone and combined with praise, was assessed in the standard laboratory punishment paradigm using 120 first and second graders as subjects. Resistance to deviation was used as the measure of punishment effectiveness. Sex of…
Mini-Muddling: Learning from Project Plan Deviations
ERIC Educational Resources Information Center
Hallgren, Markus; Wilson, Timothy L.
2007-01-01
Purpose: This paper aims to contribute to the understanding of the informal and incidental learning that takes place in project work among individuals who must adapt to deviations from project plans. Design/methodology/approach: Reflections in the study are built on four power plant projects found in an integrated provider of projects of this…
Identifying specific erotic cues in sexual deviations by audiotaped descriptions.
Abel, G G; Blanchard, E B; Barlow, D H; Mavissakalian, M
1975-01-01
Using audiotaped descriptions of sexual experiences and a direct measure of penile erection, it is possible to specify more precisely erotic cues in sexual deviates. Results indicated that such cues are highly idiosyncratic. Some tentative conclusions and suggested application for the method are discussed. PMID:1184490
Robust Confidence Interval for a Ratio of Standard Deviations
ERIC Educational Resources Information Center
Bonett, Douglas G.
2006-01-01
Comparing variability of test scores across alternate forms, test conditions, or subpopulations is a fundamental problem in psychometrics. A confidence interval for a ratio of standard deviations is proposed that performs as well as the classic method with normal distributions and performs dramatically better with nonnormal distributions. A simple…
21 CFR 211.100 - Written procedures; deviations.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...
21 CFR 211.100 - Written procedures; deviations.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...
21 CFR 211.100 - Written procedures; deviations.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Written procedures; deviations. 211.100 Section 211.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Production...
Predicting leptonic CP phase by considering deviations in charged lepton and neutrino sectors
NASA Astrophysics Data System (ADS)
Sruthilaya, M.; Soumya, C.; Deepthi, K. N.; Mohanta, R.
2015-08-01
Recently, the reactor mixing angle {θ }13 has been measured precisely by Daya Bay, RENO, and T2K experiments with a moderately large value. However, the standard form of neutrino mixing patterns such as bimaximal, tri-bimaximal, golden ratio of types A and B, hexagonal, etc., which are based on certain flavor symmetries, predict vanishing {θ }13. Using the fact that the neutrino mixing matrix can be represented as {V}{PMNS}={U}l\\dagger {U}ν {P}ν , where Ul and {U}ν result from the diagonalization of the charged lepton and neutrino mass matrices and {P}ν is a diagonal matrix containing Majorana phases, we explore the possibility of accounting for the large reactor mixing angle by considering deviations both in the charged lepton and neutrino sector. In the charged lepton sector we consider the deviation as an additional rotation in the (12) and (13) planes, whereas in the neutrino sector we consider deviations to various neutrino mixing patterns through (13) and (23) rotations. We find that with the inclusion of these deviations it is possible to accommodate the observed large reactor mixing angle {θ }13, and one can also obtain limits on the charge-conjugation parity-violating Dirac phase{δ }{CP} and Jarlskog invariant JCP for most of the cases. We then explore whether our findings can be tested in the currently running NuMI Off-axis ve Appearance experiment with three years of data taking in neutrino mode followed by three years with the anti-neutrino mode.
NASA Astrophysics Data System (ADS)
Kakehashi, Yoshiro; Chandra, Sumal
2016-04-01
We have developed a first-principles local ansatz wavefunction approach with momentum-dependent variational parameters on the basis of the tight-binding LDA+U Hamiltonian. The theory goes beyond the first-principles Gutzwiller approach and quantitatively describes correlated electron systems. Using the theory, we find that the momentum distribution function (MDF) bands of paramagnetic bcc Fe along high-symmetry lines show a large deviation from the Fermi-Dirac function for the d electrons with eg symmetry and yield the momentum-dependent mass enhancement factors. The calculated average mass enhancement m*/m = 1.65 is consistent with low-temperature specific heat data as well as recent angle-resolved photoemission spectroscopy (ARPES) data.
Beniwal, Vijay; Kumar, Anil
2016-08-24
Physico-chemical properties of liquid mixtures in general display large deviations from linear behaviour, arising out of complex specific and non-specific intermolecular interactions. The polarity of liquid mixtures displaying large positive and negative deviations can be minimized and linear mixing can be achieved in liquids using a pseudo-solvent methodology. The work described herein is designed to investigate the influence of different physical parameters on the linear pseudo-solvent composition in ionic liquid mixtures. For this purpose, we have determined the deviations from linearity, ΔE values (defined as given by ) for binary mixtures of a variety of ionic liquids, including two molecular solvents, DMSO and formamide. Firstly, the investigations were carried out in three 1-butyl-3-methylimidazolium cation based aprotic ionic liquids and the roles of anionic structure and hydrogen bond acceptor basicities (β values) of the ionic liquids were determined. The influence of the cationic structure, i.e., the hydrogen bond donor acidity (α values) and non-associative nature of the ionic liquids, was determined using C2-methylated analogs, 1-butyl-2,3-dimethylimidazolium cation based ionic liquids. The role of the protic nature of ionic liquids was studied in two protic ionic liquids, viz., 1-methylimidazolium formate and 1-methylimidazolium acetate. The effects of the temperature, pseudo-solvent structure and solvatochromic probe structure on the ΔE values were also explored.
Beniwal, Vijay; Kumar, Anil
2016-08-24
Physico-chemical properties of liquid mixtures in general display large deviations from linear behaviour, arising out of complex specific and non-specific intermolecular interactions. The polarity of liquid mixtures displaying large positive and negative deviations can be minimized and linear mixing can be achieved in liquids using a pseudo-solvent methodology. The work described herein is designed to investigate the influence of different physical parameters on the linear pseudo-solvent composition in ionic liquid mixtures. For this purpose, we have determined the deviations from linearity, ΔE values (defined as given by ) for binary mixtures of a variety of ionic liquids, including two molecular solvents, DMSO and formamide. Firstly, the investigations were carried out in three 1-butyl-3-methylimidazolium cation based aprotic ionic liquids and the roles of anionic structure and hydrogen bond acceptor basicities (β values) of the ionic liquids were determined. The influence of the cationic structure, i.e., the hydrogen bond donor acidity (α values) and non-associative nature of the ionic liquids, was determined using C2-methylated analogs, 1-butyl-2,3-dimethylimidazolium cation based ionic liquids. The role of the protic nature of ionic liquids was studied in two protic ionic liquids, viz., 1-methylimidazolium formate and 1-methylimidazolium acetate. The effects of the temperature, pseudo-solvent structure and solvatochromic probe structure on the ΔE values were also explored. PMID:27523572
The Laplace method for small deviations of Gaussian processes of Wiener type
NASA Astrophysics Data System (ADS)
Fatalov, V. R.
2005-04-01
Results on the exact asymptotics of the probabilities \\displaystyle \\mathsf P\\biggl\\{\\,\\int_0^1\\vert\\xi(t)\\vert^p\\,dt \\le\\varepsilon^p\\biggr\\},\\qquad\\varepsilon\\to 0,for p>0 are proved for two Gaussian processes \\xi(t): the Wiener process and the Brownian bridge. The method of study is the Laplace method in Banach spaces and the approach to the probabilities of small deviations based on the theory of large deviations for the occupation time. The calculations are carried out for the cases p=1 and p=2 as a result of solving the extremal problem for the action functional and studying the corresponding Schrödinger equations.
Dissociated vertical deviation-a clinical and laboratory study.
Helveston, E M
1980-01-01
The previously reported nomenclature and clinical characteristics of dissociated vertical deviation have been recorded. The incidence and characteristics of DVD have been determined by evaluation of 1,000 consecutive strabismus or nystagmus patients, and with selected chart study carried out on the 111 DVD patients found in this series. Electro-oculographic studies of selected patients with DVD provided objective evidence of the speed and amplitude of the ocular movements in DVD. Bell phenomenon, strabismus sursoadductorius and the Bielschowsky phenomenon were recorded and compared to clinical findings of strabismus patients with DVD. The technique for the results of surgery for DVD were described. Dissociated vertical deviation was characterized as a component of the overall strabismus picture. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 1 D FIGURE 1 E FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 3 A FIGURE 3 B FIGURE 3 C FIGURE 4 A FIGURE 4 B PMID:7020216
Progressive increase in the angle of deviation in congenital esotropia.
Ing, M R
1994-01-01
The majority of patients with congenital esotropia in this consecutive series of 41 patients showed an increase in the angle of deviation when followed over an average of 3 months. The ages at the initial measurement and surgery, the cycloplegic refraction, and the clinical response to patching could not be used to identify those patients with a progressive increase in the quantity of the deviation. It was found, however, that if the preliminary surgical plan was adjusted (as it was in the majority of the patients in this series) to reflect the latest measurements obtained the day before surgery, a relatively high percentage of patients (90%) could be found to have achieved satisfactory alignment by the 6-week postoperative visit. PMID:7886860
Deviation from the superparamagnetic behaviour of fine-particle systems
NASA Astrophysics Data System (ADS)
Mălăescu, I.; Marin, C. N.
2000-07-01
Studies concerning superparamagnetic behaviour of fine magnetic particle systems were performed using static and radiofrequency measurements, in the range 1-60 MHz. The samples were: a ferrofluid with magnetite particles dispersed in kerosene (sample A), magnetite powder (sample B) and the same magnetite powder dispersed in a polymer (sample C). Radiofrequency measurements indicated a maximum in the imaginary part of the complex magnetic susceptibility, for each of the samples, at frequencies with the magnitude order of tens of MHz, the origin of which was assigned to Néel-type relaxation processes. The static measurements showed a Langevin-type dependence of magnetisation M and of susceptibility χ, on the magnetic field for sample A. For samples B and C deviations from this type of dependence were found. These deviations were analysed qualitatively and explained in terms of the interparticle interactions, dispersion medium influence and surface effects.
Deviations from Liquidlike Behavior in Molten Polymer Films at Interfaces
NASA Astrophysics Data System (ADS)
Seo, Young-Soo; Koga, T.; Sokolov, J.; Rafailovich, M. H.; Tolan, M.; Sinha, S.
2005-04-01
We have performed x-ray specular and diffuse scattering on liquid polymer films and analyzed the spectra as a function of film thickness and molecular weight. The results show that films whose molecular weight is close to the entanglement length behave as simple liquids except that the shortest wavelength is determined by the radius of gyration (Rg) rather than the monomer-monomer distance. When the molecular weight is higher than the entanglement length, the strong deviations from liquidlike behavior are observed. We find that the long wavelength cutoff vector, ql,c, scales with film thickness, d as d-1.1±0.1 rather than the usual d-2 expected for simple liquids. If we assume that these deviations are due to surface pinning of the polymer chains, then our results are consistent with the formalism developed by Fredrickson et al. to explain the capillary wave spectrum that can propagate in a polymer brush.
Central compensation of deviated subjective visual vertical in Wallenberg's syndrome
Cnyrim, Christian Daniel; Rettinger, Nicole; Mansmann, Ulrich; Brandt, Thomas; Strupp, Michael
2007-01-01
The central compensation of vestibular tonus imbalance due to unilateral peripheral vestibular lesions has been repeatedly documented. Little is known, however, about the central compensation of vestibular tonus imbalance due to central lesions. Dorsolateral medullary infarctions (Wallenberg's syndrome) typically cause a central vestibular tonus imbalance in the roll plane with deviations of perceived verticality and ipsiversive body lateropulsion. The course of normalisation of the tilts of subjective visual vertical (SVV) in 50 patients who had acute Wallenberg's syndrome were retrospectively compared with that in 50 patients with acute vestibular neuritis. The initial displacement of SVV was 9.8° in Wallenberg's syndrome and 7° in vestibular neuritis. The deviation of SVV significantly decreased over time within days to weeks in both groups. This finding shows that the time courses of the central compensation for dorsolateral medullary infarctions and peripheral vestibular lesions are similar. PMID:17435189
OSMOSIS: A CAUSE OF APPARENT DEVIATIONS FROM DARCY'S LAW.
Olsen, Harold W.
1985-01-01
This review of the existing evidence shows that osmosis causes intercepts in flow rate versus hydraulic gradient relationships that are consistent with the observed deviations from Darcy's law at very low gradients. Moreover, it is suggested that a natural cause of osmosis in laboratory samples could be chemical reactions such as those involved in aging effects. This hypothesis is analogous to the previously proposed occurrence of electroosmosis in nature generated by geochemical weathering reactions. Refs.
Education and the Reality Principle.
ERIC Educational Resources Information Center
Bettelheim, Bruno
1979-01-01
All education is based on a middle-class morality that finds its psychoanalytic equivalent in a reality principle which insists that present pleasure must be largely foregone for greater gains in the future. Schools, however, have yet to develop ways to teach low-income students this middle-class value. (Author/GC)
Geometric deviation modeling by kinematic matrix based on Lagrangian coordinate
NASA Astrophysics Data System (ADS)
Liu, Weidong; Hu, Yueming; Liu, Yu; Dai, Wanyi
2015-09-01
Typical representation of dimension and geometric accuracy is limited to the self-representation of dimension and geometric deviation based on geometry variation thinking, yet the interactivity affection of geometric variation and gesture variation of multi-rigid body is not included. In this paper, a kinematic matrix model based on Lagrangian coordinate is introduced, with the purpose of unified model for geometric variation and gesture variation and their interactive and integrated analysis. Kinematic model with joint, local base and movable base is built. The ideal feature of functional geometry is treated as the base body; the fitting feature of functional geometry is treated as the adjacent movable body; the local base of the kinematic model is fixed onto the ideal geometry, and the movable base of the kinematic model is fixed onto the fitting geometry. Furthermore, the geometric deviation is treated as relative location or rotation variation between the movable base and the local base, and it's expressed by the Lagrangian coordinate. Moreover, kinematic matrix based on Lagrangian coordinate for different types of geometry tolerance zones is constructed, and total freedom for each kinematic model is discussed. Finally, the Lagrangian coordinate library, kinematic matrix library for geometric deviation modeling is illustrated, and an example of block and piston fits is introduced. Dimension and geometric tolerances of the shaft and hole fitting feature are constructed by kinematic matrix and Lagrangian coordinate, and the results indicate that the proposed kinematic matrix is capable and robust in dimension and geometric tolerances modeling.
Quantifying prosthetic gait deviation using simple outcome measures
Kark, Lauren; Odell, Ross; McIntosh, Andrew S; Simmons, Anne
2016-01-01
AIM: To develop a subset of simple outcome measures to quantify prosthetic gait deviation without needing three-dimensional gait analysis (3DGA). METHODS: Eight unilateral, transfemoral amputees and 12 unilateral, transtibial amputees were recruited. Twenty-eight able-bodied controls were recruited. All participants underwent 3DGA, the timed-up-and-go test and the six-minute walk test (6MWT). The lower-limb amputees also completed the Prosthesis Evaluation Questionnaire. Results from 3DGA were summarised using the gait deviation index (GDI), which was subsequently regressed, using stepwise regression, against the other measures. RESULTS: Step-length (SL), self-selected walking speed (SSWS) and the distance walked during the 6MWT (6MWD) were significantly correlated with GDI. The 6MWD was the strongest, single predictor of the GDI, followed by SL and SSWS. The predictive ability of the regression equations were improved following inclusion of self-report data related to mobility and prosthetic utility. CONCLUSION: This study offers a practicable alternative to quantifying kinematic deviation without the need to conduct complete 3DGA. PMID:27335814
Analysis and interpretation of stress indicators in deviated wells of the Coso Geothermal Field
NASA Astrophysics Data System (ADS)
Schoenball, Martin; Glen, Jonathan M. G.; Davatzes, Nicholas C.
2016-04-01
Characterizing the tectonic stress field is an integral part for the development of hydrothermal systems, especially enhanced geothermal systems (EGS). With a known stress field, critically stressed faults can be identified. Faults that are critically oriented with respect to the in-situ stress field exhibit a high tendency for slip, and thus are likely candidates for reactivation during the creation of an EGS. Reactivated faults are known to serve as dominant fluid pathways during hydrothermal circulation and the characteristics of this process determine the potential for damaging earthquakes; should extensive portions of well-oriented, large features be reactivated. As part of the FORGE initiative at the West Flank of the Coso Geothermal Field, we analyze a large set of image logs obtained from wells distributed across the geothermal field for details about the stress state revealed by indicators such as borehole breakouts and drilling-induced tensile fractures. Previous stress analyses at Coso have ignored deviated well sections, since their interpretation for the orientation of the stress tensor is non-unique with respect to varying stress magnitudes. Using interpreted borehole-induced structures, we perform a grid search over all possible Andersonian stress states and find a best fitting vertical stress tensor for each stress state characterized by principal stress magnitudes. By including deviated well sections and recently drilled wells, we considerably expand the suite of stress measurements in the Coso Geothermal Field. Along individual wells, this analysis also reveals local meter length-scale deviations from the best-fitting mean stress orientation. While most wells show consistent horizontal principal stress orientations with standard deviations of about 10°, other wells show large standard deviations on the order of 25°. Several regions have logged well trajectories with lateral spacing below 1 km. This enables us to trace changes of the stress
Barton, Gabor J; Hawken, Malcolm B; Holmes, Gill; Schwartz, Michael H
2015-01-01
The ability of the Movement Deviation Profile (MDP) and Gait Deviation Index (GDI) to detect gait changes was compared in a child with cerebral palsy who underwent game training. Conventional gait analysis showed that sagittal plane angles became mirrored about normality after training. Despite considerable gait changes, the GDI showed minimal change, while the MDP detected a difference equal to a shift between 10-9 on the Functional Assessment Questionnaire scale. Responses of the GDI and MDP were examined during a synthetic transition of the patient's curves from before intervention to a state mirrored about normality. The GDI showed a symmetric response on the two opposite sides of normality but the neural network based MDP gave an asymmetric response reflecting faithfully the unequal biomechanical consequences of joint angle changes. In conclusion, the MDP can detect altered gait even if the changes are missed by the GDI. PMID:23521124
Barton, Gabor J; Hawken, Malcolm B; Holmes, Gill; Schwartz, Michael H
2015-01-01
The ability of the Movement Deviation Profile (MDP) and Gait Deviation Index (GDI) to detect gait changes was compared in a child with cerebral palsy who underwent game training. Conventional gait analysis showed that sagittal plane angles became mirrored about normality after training. Despite considerable gait changes, the GDI showed minimal change, while the MDP detected a difference equal to a shift between 10-9 on the Functional Assessment Questionnaire scale. Responses of the GDI and MDP were examined during a synthetic transition of the patient's curves from before intervention to a state mirrored about normality. The GDI showed a symmetric response on the two opposite sides of normality but the neural network based MDP gave an asymmetric response reflecting faithfully the unequal biomechanical consequences of joint angle changes. In conclusion, the MDP can detect altered gait even if the changes are missed by the GDI.
Mostajeran, M.
2014-11-15
In this work, a “main condition” for phase stability has been employed to investigate the effects of the velocity deviation of the electrons in DC-biased single-sided multipactors (MPs). In a previous study [M. Mostajeran, Phys. Plasmas 21, 053108 (2014)], a stability equation was derived, where the secondary electron was assumed to have zero initial velocity and the phase deviation from the resonant phase was considered. In this work, both deviations in phase and velocity from the resonant condition are taken into account, assuming nonzero initial velocity for the secondary electrons. Using the main condition for stability, it is shown that MP discharge can rise in situations, where large velocity deviations from initial velocity and large phase deviations from resonant phase exist. This is contrary to what can be predicted on the basis of the “simple stability condition.” This result is further confirmed by numerical simulations.
NASA Astrophysics Data System (ADS)
Zorn, R.
1997-03-01
In this article neutron-scattering experiments using the backscattering instrument IN13 on the glass-forming polymer polybutadiene are reported. As compared to other neutron spectrometers IN13 has a large range of wave vectors Q accessible. Therefore, a better statement can be made about the spatial extent of the observed motions. In order to obtain reliable results for the Q dependence a multiple scattering correction of the intensities has been performed. The Q dependence of the incoherent scattering from polybutadiene shows strong deviations from the Gaussian approximation at high Q. These deviations are interpreted under different microscopical model assumptions. Finally, a picture of a distribution of anharmonic potentials can give account for the observed deviation from Gaussian behavior in the incoherent intermediate scattering function at low temperatures. At higher temperatures the fast motion in these potentials is superimposed by a long-range diffusional motion. The latter may be extracted assuming a model for the fast motion. It shows certain characteristics of fractal diffusion but defies a simple scaling approach.
Babinet's principle in double-refraction systems
NASA Astrophysics Data System (ADS)
Ropars, Guy; Le Floch, Albert
2014-06-01
Babinet's principle applied to systems with double refraction is shown to involve spatial interchanges between the ordinary and extraordinary patterns observed through two complementary screens. As in the case of metamaterials, the extraordinary beam does not follow the Snell-Descartes refraction law, the superposition principle has to be applied simultaneously at two points. Surprisingly, by contrast to the intuitive impression, in the presence of the screen with an opaque region, we observe that the emerging extraordinary photon pattern, which however has undergone a deviation, remains fixed when a natural birefringent crystal is rotated while the ordinary one rotates with the crystal. The twofold application of Babinet's principle implies intensity and polarization interchanges but also spatial and dynamic interchanges which should occur in birefringent metamaterials.
Teaching Standard Deviation by Building from Student Invention
ERIC Educational Resources Information Center
Day, James; Nakahara, Hiroko; Bonn, Doug
2010-01-01
First-year physics laboratories are often driven by a mix of goals that includes the illustration or discovery of basic physics principles and a myriad of technical skills involving specific equipment, data analysis, and report writing. The sheer number of such goals seems guaranteed to produce cognitive overload, even when highly detailed…
Quality Assessment of Vertical Angular Deviations for Photometer Calibration Benches
NASA Astrophysics Data System (ADS)
Silva Ribeiro, A.; Costa Santos, A.; Alves Sousa, J.; Forbes, A. B.
2015-02-01
Lighting, both natural and electric, constitutes one of the most important aspects of the life of human beings, allowing us to see and perform our daily tasks in outdoor and indoor environments. The safety aspects of lighting are self-evident in areas such as road lighting, urban lighting and also indoor lighting. The use of photometers to measure lighting levels requires traceability obtained in accredited laboratories, which must provide an associated uncertainty. It is therefore relevant to study the impact of known uncertainty sources like the vertical angular deviation of photometer calibration benches, in order to define criteria to its quality assessment.
Deviations in tribimaximal mixing from sterile neutrino sector
NASA Astrophysics Data System (ADS)
Dev, S.; Raj, Desh; Gautam, Radha Raman
2016-10-01
We explore the possibility of generating a non-zero Ue3 element of the neutrino mixing matrix from tribimaximal neutrino mixing by adding a light sterile neutrino to the active neutrinos. Small active-sterile mixing can provide the necessary deviation from tribimaximal mixing to generate a non-zero θ13 and atmospheric mixing θ23 different from maximal. Assuming no CP-violation, we study the phenomenological impact of sterile neutrinos in the context of current neutrino oscillation data. The tribimaximal pattern is broken in such a manner that the second column of tribimaximal mixing remains intact in the neutrino mixing matrix.
Distribution of standard deviation of an observable among superposed states
NASA Astrophysics Data System (ADS)
Yu, Chang-shui; Shao, Ting-ting; Li, Dong-mo
2016-10-01
The standard deviation (SD) quantifies the spread of the observed values on a measurement of an observable. In this paper, we study the distribution of SD among the different components of a superposition state. It is found that the SD of an observable on a superposition state can be well bounded by the SDs of the superposed states. We also show that the bounds also serve as good bounds on coherence of a superposition state. As a further generalization, we give an alternative definition of incompatibility of two observables subject to a given state and show how the incompatibility subject to a superposition state is distributed.
Principles of project management
NASA Technical Reports Server (NTRS)
1982-01-01
The basic principles of project management as practiced by NASA management personnel are presented. These principles are given as ground rules and guidelines to be used in the performance of research, development, construction or operational assignments.
Intuitions, principles and consequences.
Shaw, A B
2001-02-01
Some approaches to the assessment of moral intuitions are discussed. The controlled ethical trial isolates a moral issue from confounding factors and thereby clarifies what a person's intuition actually is. Casuistic reasoning from situations, where intuitions are clear, suggests or modifies principles, which can then help to make decisions in situations where intuitions are unclear. When intuitions are defended by a supporting principle, that principle can be tested by finding extreme cases, in which it is counterintuitive to follow the principle. An approach to the resolution of conflict between valid moral principles, specifically the utilitarian and justice principles, is considered. It is argued that even those who justify intuitions by a priori principles are often obliged to modify or support their principles by resort to the consideration of consequences.
Chemical Principls Exemplified
ERIC Educational Resources Information Center
Plumb, Robert C.
1973-01-01
Two topics are discussed: (1) Stomach Upset Caused by Aspirin, illustrating principles of acid-base equilibrium and solubility; (2) Physical Chemistry of the Drinking Duck, illustrating principles of phase equilibria and thermodynamics. (DF)
Deviations from Curie-Weiss behavior in spin-glasses
NASA Astrophysics Data System (ADS)
Rao, K. V.; Fähnle, M.; Figueroa, E.; Beckman, O.; Hedman, L.
1983-03-01
The magnetic susceptibility in the spin-glass concentration regime of amorphous alloys (FexNi1-x)75P16B6Al3 with x=0.04, 0.06, and 0.08 has been measured using a superconducting quantum interference detector magnetometer with an external field of 5 Oe for temperatures 5<=T<=60.5 K, and a Faraday balance with an external field of 5 kOe for 4.3<=T<=300 K. We observe a high-temperature (T>20Tf) Curie-Weiss law with positive values for the paramagnetic Curie temperature, indicating predominantly ferromagnetic exchange couplings. At temperatures approaching the spin-glass freezing temperature, however, there are strong deviations from Curie-Weiss behavior. A simple theory is developed which allows a determination of the angular spin correlations in the spin-glass ground state from these deviations. The number of such correlated spins (1.5 to 4.4) determined from our data compares well with computer-simulation studies by Walker and Walstedt as well as data obtained by other authors for Au-Fe, Cu-Mn, and Co- and Mn-aluminosilicate spin-glasses.
Altitude deviations: Breakdowns of an error-tolerant system
NASA Technical Reports Server (NTRS)
Palmer, Everett A.; Hutchins, Edwin L.; Ritter, Richard D.; Vancleemput, Inge
1993-01-01
Pilot reports of aviation incidents to the Aviation Safety Reporting System (ASRS) provide a window on the problems occurring in today's airline cockpits. The narratives of 10 pilot reports of errors made in the automation-assisted altitude-change task are used to illustrate some of the issues of pilots interacting with automatic systems. These narratives are then used to construct a description of the cockpit as an information processing system. The analysis concentrates on the error-tolerant properties of the system and on how breakdowns can occasionally occur. An error-tolerant system can detect and correct its internal processing errors. The cockpit system consists of two or three pilots supported by autoflight, flight-management, and alerting systems. These humans and machines have distributed access to clearance information and perform redundant processing of information. Errors can be detected as deviations from either expected behavior or as deviations from expected information. Breakdowns in this system can occur when the checking and cross-checking tasks that give the system its error-tolerant properties are not performed because of distractions or other task demands. Recommendations based on the analysis for improving the error tolerance of the cockpit system are given.
ERIC Educational Resources Information Center
Beim, George
This book is written to give a better understanding of the principles of modern soccer to coaches and players. In nine chapters the following elements of the game are covered: (1) the development of systems; (2) the principles of attack; (3) the principles of defense; (4) training games; (5) strategies employed in restarts; (6) physical fitness…
Chemical Principles Exemplified
ERIC Educational Resources Information Center
Plumb, Robert C.
1970-01-01
This is the first of a new series of brief ancedotes about materials and phenomena which exemplify chemical principles. Examples include (1) the sea-lab experiment illustrating principles of the kinetic theory of gases, (2) snow-making machines illustrating principles of thermodynamics in gas expansions and phase changes, and (3) sunglasses that…
48 CFR 2401.471 - Requests for deviations-FAR and HUDAR.
Code of Federal Regulations, 2014 CFR
2014-10-01
... deviations—FAR and HUDAR. (a) Requests for deviations from the FAR or HUDAR shall be submitted in writing to... from which a deviation is sought; (3) Fully describe the deviation, its intended effect, and the... authorize deviations via telephone or electronic mail. Such authorizations will be confirmed in writing....
Temperature deviation index and elderly mortality in Japan
NASA Astrophysics Data System (ADS)
Lim, Youn-Hee; Reid, Colleen E.; Honda, Yasushi; Kim, Ho
2016-07-01
Few studies have examined how the precedence of abnormal temperatures in previous neighboring years affects the population's health. In the present study, we attempted to quantify the health effects of abnormal weather patterns by creating a metric called the temperature deviation index (TDI) and estimated the effects of TDI on mortality in Japan. We used data from 47 prefectures in Japan to compute the TDI on days between May and September from 1966 to 2010. The TDI is a summed product of an indicator of absence of high temperatures in the neighboring years, and more weights were assigned to the years closest to the current year. To estimate the TDI effects on elderly mortality, we used generalized linear modeling with a Poisson distribution after adjusting for apparent temperature, barometric pressure, day of the week, and time trend. For each prefecture, we estimated the TDI effects and pooled the estimates to yield a national average for 1991-2010 in Japan. The estimated effects of TDI in middle- or high-latitude prefectures were greater than in low-latitude prefectures. The estimated national average of TDI effects was a 0.5 % (95 % confidence intervals [CI], 0.1, 1.0) increase in elderly mortality per 1-unit (around 1 standard deviation) increase in the TDI. The significant pooled estimation of TDI effects was mainly due to the TDI effects on summer days with moderate temperature (25th-49th percentile, mean temperature 22.9 °C): a 1.9 % (95 % CI, 1.1, 2.6) increase in elderly mortality per 1-unit increase in the TDI. However, TDI effects were insignificant in other temperature ranges. These findings suggest that elderly deaths increased on moderate temperature days in the summer that differed substantially from days during that time window in the neighboring years. Therefore, not only high temperature itself but also temperature deviation compared to previous years could be considered to be a risk factor for elderly mortality in the summer.
Temperature deviation index and elderly mortality in Japan.
Lim, Youn-Hee; Reid, Colleen E; Honda, Yasushi; Kim, Ho
2016-07-01
Few studies have examined how the precedence of abnormal temperatures in previous neighboring years affects the population's health. In the present study, we attempted to quantify the health effects of abnormal weather patterns by creating a metric called the temperature deviation index (TDI) and estimated the effects of TDI on mortality in Japan. We used data from 47 prefectures in Japan to compute the TDI on days between May and September from 1966 to 2010. The TDI is a summed product of an indicator of absence of high temperatures in the neighboring years, and more weights were assigned to the years closest to the current year. To estimate the TDI effects on elderly mortality, we used generalized linear modeling with a Poisson distribution after adjusting for apparent temperature, barometric pressure, day of the week, and time trend. For each prefecture, we estimated the TDI effects and pooled the estimates to yield a national average for 1991-2010 in Japan. The estimated effects of TDI in middle- or high-latitude prefectures were greater than in low-latitude prefectures. The estimated national average of TDI effects was a 0.5 % (95 % confidence intervals [CI], 0.1, 1.0) increase in elderly mortality per 1-unit (around 1 standard deviation) increase in the TDI. The significant pooled estimation of TDI effects was mainly due to the TDI effects on summer days with moderate temperature (25th-49th percentile, mean temperature 22.9 °C): a 1.9 % (95 % CI, 1.1, 2.6) increase in elderly mortality per 1-unit increase in the TDI. However, TDI effects were insignificant in other temperature ranges. These findings suggest that elderly deaths increased on moderate temperature days in the summer that differed substantially from days during that time window in the neighboring years. Therefore, not only high temperature itself but also temperature deviation compared to previous years could be considered to be a risk factor for elderly mortality in the summer. PMID
Standard deviation of luminance distribution affects lightness and pupillary response.
Kanari, Kei; Kaneko, Hirohiko
2014-12-01
We examined whether the standard deviation (SD) of luminance distribution serves as information of illumination. We measured the lightness of a patch presented in the center of a scrambled-dot pattern while manipulating the SD of the luminance distribution. Results showed that lightness decreased as the SD of the surround stimulus increased. We also measured pupil diameter while viewing a similar stimulus. The pupil diameter decreased as the SD of luminance distribution of the stimuli increased. We confirmed that these results were not obtained because of the increase of the highest luminance in the stimulus. Furthermore, results of field measurements revealed a correlation between the SD of luminance distribution and illuminance in natural scenes. These results indicated that the visual system refers to the SD of the luminance distribution in the visual stimulus to estimate the scene illumination. PMID:25606770
The deviation of growth model for transparent conductive graphene
2014-01-01
An approximate growth model was employed to predict the time required to grow a graphene film by chemical vapor deposition (CVD). Monolayer graphene films were synthesized on Cu foil at various hydrogen flow rates from 10 to 50 sccm. The sheet resistance of the graphene film was 310Ω/□ and the optical transmittance was 97.7%. The Raman intensity ratio of the G-peak to the 2D peak of the graphene film was as high as ~4 when the hydrogen flow rate was 30 sccm. The fitting curve obtained by the deviation equation of growth model closely matches the data. We believe that under the same conditions and with the same setup, the presented growth model can help manufacturers and academics to predict graphene growth time more accurately. PMID:25364316
Probing deviations from tribimaximal mixing through ultrahigh energy neutrino signals
Majumdar, Debasish; Ghosal, Ambar
2007-06-01
We investigate deviation from the tribimaximal mixing in the case of ultrahigh energy neutrino using the ICECUBE detector. We consider the ratio of the number of muon tracks to the shower generated due to eletrons and hadrons. Our analysis shows that for tribimaximal mixing the ratio comes out around 4.05. Keeping {theta}{sub 12} and {theta}{sub 23} fixed at tribimaximal value, we have varied the angle {theta}{sub 13}=3 deg. , 6 deg. , 9 deg. and the value of the ratio gradually decreases. The variation of ratio lies within 8% to 18% from the tribimaximal mixing value and it is very difficult to detect such a small variation by the ICECUBE detector.
The deviation of growth model for transparent conductive graphene
NASA Astrophysics Data System (ADS)
Chan, Shih-Hao; Chen, Jia-Wei; Chen, Hung-Pin; Wei, Hung-Sen; Li, Meng-Chi; Chen, Sheng-Hui; Lee, Cheng-Chung; Kuo, Chien-Cheng
2014-10-01
An approximate growth model was employed to predict the time required to grow a graphene film by chemical vapor deposition (CVD). Monolayer graphene films were synthesized on Cu foil at various hydrogen flow rates from 10 to 50 sccm. The sheet resistance of the graphene film was 310Ω/□ and the optical transmittance was 97.7%. The Raman intensity ratio of the G-peak to the 2D peak of the graphene film was as high as ~4 when the hydrogen flow rate was 30 sccm. The fitting curve obtained by the deviation equation of growth model closely matches the data. We believe that under the same conditions and with the same setup, the presented growth model can help manufacturers and academics to predict graphene growth time more accurately.
Standard deviation of luminance distribution affects lightness and pupillary response.
Kanari, Kei; Kaneko, Hirohiko
2014-12-01
We examined whether the standard deviation (SD) of luminance distribution serves as information of illumination. We measured the lightness of a patch presented in the center of a scrambled-dot pattern while manipulating the SD of the luminance distribution. Results showed that lightness decreased as the SD of the surround stimulus increased. We also measured pupil diameter while viewing a similar stimulus. The pupil diameter decreased as the SD of luminance distribution of the stimuli increased. We confirmed that these results were not obtained because of the increase of the highest luminance in the stimulus. Furthermore, results of field measurements revealed a correlation between the SD of luminance distribution and illuminance in natural scenes. These results indicated that the visual system refers to the SD of the luminance distribution in the visual stimulus to estimate the scene illumination.
Prevalence of voice quality deviations in the normal adult population.
Brindle, B R; Morris, H L
1979-11-01
The purpose of this study was to determine the prevalence of voice quality deviations in a normal adult population. One-hundred twelve subjects, aged 17 to 80, read a short paragraph aloud into a high-fidelity tape recorder and completed a case history questionnaire. A group of 11 pretrained judges rated overall performance of each taped sample on a seven-point equal-appearing intervals scale, then designated those quality components which contributed toward deviant ratings. Eighty-two percent of the group received a mean severity rating lower than 1.99; 16% had a rating between 2.00 and 2.99; and 2% was assigned a mean rating higher than 3.00.
Deviations from uniform power law scaling in nonstationary time series
NASA Technical Reports Server (NTRS)
Viswanathan, G. M.; Peng, C. K.; Stanley, H. E.; Goldberger, A. L.
1997-01-01
A classic problem in physics is the analysis of highly nonstationary time series that typically exhibit long-range correlations. Here we test the hypothesis that the scaling properties of the dynamics of healthy physiological systems are more stable than those of pathological systems by studying beat-to-beat fluctuations in the human heart rate. We develop techniques based on the Fano factor and Allan factor functions, as well as on detrended fluctuation analysis, for quantifying deviations from uniform power-law scaling in nonstationary time series. By analyzing extremely long data sets of up to N = 10(5) beats for 11 healthy subjects, we find that the fluctuations in the heart rate scale approximately uniformly over several temporal orders of magnitude. By contrast, we find that in data sets of comparable length for 14 subjects with heart disease, the fluctuations grow erratically, indicating a loss of scaling stability.
Image contrast enhancement based on a local standard deviation model
Chang, Dah-Chung; Wu, Wen-Rong
1996-12-31
The adaptive contrast enhancement (ACE) algorithm is a widely used image enhancement method, which needs a contrast gain to adjust high frequency components of an image. In the literature, the gain is usually inversely proportional to the local standard deviation (LSD) or is a constant. But these cause two problems in practical applications, i.e., noise overenhancement and ringing artifact. In this paper a new gain is developed based on Hunt`s Gaussian image model to prevent the two defects. The new gain is a nonlinear function of LSD and has the desired characteristic emphasizing the LSD regions in which details are concentrated. We have applied the new ACE algorithm to chest x-ray images and the simulations show the effectiveness of the proposed algorithm.
Efficient computation of root mean square deviations under rigid transformations.
Hildebrandt, Anna K; Dietzen, Matthias; Lengauer, Thomas; Lenhof, Hans-Peter; Althaus, Ernst; Hildebrandt, Andreas
2014-04-15
The computation of root mean square deviations (RMSD) is an important step in many bioinformatics applications. If approached naively, each RMSD computation takes time linear in the number of atoms. In addition, a careful implementation is required to achieve numerical stability, which further increases runtimes. In practice, the structural variations under consideration are often induced by rigid transformations of the protein, or are at least dominated by a rigid component. In this work, we show how RMSD values resulting from rigid transformations can be computed in constant time from the protein's covariance matrix, which can be precomputed in linear time. As a typical application scenario is protein clustering, we will also show how the Ward-distance which is popular in this field can be reduced to RMSD evaluations, yielding a constant time approach for their computation.
Deviations from ideal behavior in isotopic mixtures of ammonia
NASA Astrophysics Data System (ADS)
Lopes, J. N. Canongia; Rebelo, L. P. N.; Calado, J. C. G.
2001-09-01
The vapor pressure isotope effect between samples of isotopically substituted ammonia, NH3, ND3 and 15NH3, and their mixtures was measured as a function of temperature (225
The deviation of growth model for transparent conductive graphene.
Chan, Shih-Hao; Chen, Jia-Wei; Chen, Hung-Pin; Wei, Hung-Sen; Li, Meng-Chi; Chen, Sheng-Hui; Lee, Cheng-Chung; Kuo, Chien-Cheng
2014-01-01
An approximate growth model was employed to predict the time required to grow a graphene film by chemical vapor deposition (CVD). Monolayer graphene films were synthesized on Cu foil at various hydrogen flow rates from 10 to 50 sccm. The sheet resistance of the graphene film was 310Ω/□ and the optical transmittance was 97.7%. The Raman intensity ratio of the G-peak to the 2D peak of the graphene film was as high as ~4 when the hydrogen flow rate was 30 sccm. The fitting curve obtained by the deviation equation of growth model closely matches the data. We believe that under the same conditions and with the same setup, the presented growth model can help manufacturers and academics to predict graphene growth time more accurately. PMID:25364316
Does Nasal Septal Deviation Affect the Success of Tympanoplasty Surgery?
Tan, M; Kalcioglu, MT; Akarcay, M; Toplu, Y; Karaca, S
2015-01-01
ABSTRACT Objective: This paper deals with the investigation of the effects of nasal septal deviation evaluated by acoustic rhinometry (ARM) in the success of tympanoplasty surgery. Subject and Methods: All patients who underwent tympanoplasty surgery by the same surgeon were reviewed. The patients with nasopharyngeal or nasal masses, polyps, symptoms of allergic rhinitis or rhinosinusitis, or concha bullosa were excluded from the study. Forty patients who underwent tympanoplasty at least one year ago were included in the study. The patients were divided into two groups according to the graft success results. Acoustic rhinometry evaluations of the patients were performed. Results: There were 25 and 15 cases in the intact graft (group A) and re-perforated group (group B), respectively. For the same side of the operated ear, ARM values of group A were 0.47 cm 2 at the first narrowest cross-sectional area (MCA 1), 0.43 cm2 at the second narrowest cross-sectional area (MCA 2), 1.51 cm3 volume at the first 2 cm of the nasal cavity (Vol 1) and 3.33 cm3 volume between the second and fifth cm of the nasal cavity (Vol 2). Acoustic rhinometry values of group B were 0.50 cm2, 0.47 cm2, 1.60 cm3 and 3.19 cm3 for MCA 1, MCA 2, Vol 1, and Vol 2, respectively. Conclusion: The results of this study showed that nasal septal deviation may not affect the success of tympanoplasty surgery, and septoplasty may not be necessary before ear surgery. PMID:26624593
Spine deviations and orthodontic treatment of asymmetric malocclusions in children
2012-01-01
Background The aim of this randomized clinical trial was to assess the effect of early orthodontic treatment for unilateral posterior cross bite in the late deciduous and early mixed dentition using orthopedic parameters. Methods Early orthodontic treatment was performed by initial maxillary expansion and subsequent activator therapy (Münster treatment concept). The patient sample was initially comprised of 80 patients with unilateral posterior cross bite (mean age 7.3 years, SD 2.1 years). After randomization, 77 children attended the initial examination appointment (therapy = 37, control = 40); 31 children in the therapy group and 35 children in the control group were monitored at the follow-up examination (T2). The mean interval between T1 and T2 was 1.1 years (SD 0.2 years). Rasterstereography was used for back shape analysis at T1 and T2. Using the profile, the kyphotic and lordotic angle, the surface rotation, the lateral deviation, pelvic tilt and pelvic torsion, statistical differences at T1 and T2 between the therapy and control groups were calculated (t-test). Our working hypothesis was, that early orthodontic treatment can induce negative therapeutic changes in body posture through thoracic and lumbar position changes in preadolescents with uniltaral cross bite. Results No clinically relevant differences between the control and the therapy groups at T1 and T2 were found for the parameters of kyphotic and lordotic angle, the surface rotation, lateral deviation, pelvic tilt, and pelvic torsion. Conclusions Our working hypothesis was tested to be not correct (within the limitations of this study). This randomized clinical trial demonstrates that in a juvenile population with unilateral posterior cross bite the selected early orthodontic treatment protocol does not affect negatively the postural parameters. Trial registration DRKS00003497 on DRKS PMID:22906114
Deviation from Power Law Behavior in Landslide Phenomenon
NASA Astrophysics Data System (ADS)
Li, L.; Lan, H.; Wu, Y.
2013-12-01
Power law distribution of magnitude is widely observed in many natural hazards (e.g., earthquake, floods, tornadoes, and forest fires). Landslide is unique as the size distribution of landslide is characterized by a power law decrease with a rollover in the small size end. Yet, the emergence of the rollover, i.e., the deviation from power law behavior for small size landslides, remains a mystery. In this contribution, we grouped the forces applied on landslide bodies into two categories: 1) the forces proportional to the volume of failure mass (gravity and friction), and 2) the forces proportional to the area of failure surface (cohesion). Failure occurs when the forces proportional to volume exceed the forces proportional to surface area. As such, given a certain mechanical configuration, the failure volume to failure surface area ratio must exceed a corresponding threshold to guarantee a failure. Assuming all landslides share a uniform shape, which means the volume to surface area ratio of landslide regularly increase with the landslide volume, a cutoff of landslide volume distribution in the small size end can be defined. However, in realistic landslide phenomena, where heterogeneities of landslide shape and mechanical configuration are existent, a simple cutoff of landslide volume distribution does not exist. The stochasticity of landslide shape introduce a probability distribution of the volume to surface area ratio with regard to landslide volume, with which the probability that the volume to surface ratio exceed the threshold can be estimated regarding values of landslide volume. An experiment based on empirical data showed that this probability can induce the power law distribution of landslide volume roll down in the small size end. We therefore proposed that the constraints on the failure volume to failure surface area ratio together with the heterogeneity of landslide geometry and mechanical configuration attribute for the deviation from power law
Physical principles of hearing
NASA Astrophysics Data System (ADS)
Martin, Pascal
2015-10-01
The following sections are included: * Psychophysical properties of hearing * The cochlear amplifier * Mechanosensory hair cells * The "critical" oscillator as a general principle of auditory detection * Bibliography
Bateman's principle and immunity.
Rolff, Jens
2002-01-01
The immunocompetence handicap hypothesis (ICHH) of Folstad and Karter has inspired a large number of studies that have tried to understand the causal basis of parasite-mediated sexual selection. Even though this hypothesis is based on the double function of testosterone, a hormone restricted to vertebrates, studies of invertebrates have tended to provide central support for specific predictions of the ICHH. I propose an alternative hypothesis that explains many of the findings without relying on testosterone or other biochemical feedback loops. This alternative is based on Bateman's principle, that males gain fitness by increasing their mating success whilst females increase fitness through longevity because their reproductive effort is much higher. Consequently, I predict that females should invest more in immunity than males. The extent of this dimorphism is determined by the mating system and the genetic correlation between males and females in immune traits. In support of my arguments, I mainly use studies on insects that share innate immunity with vertebrates and have the advantage that they are easier to study. PMID:11958720
Criteria for deviation from predictions by the concentration addition model.
Takeshita, Jun-Ichi; Seki, Masanori; Kamo, Masashi
2016-07-01
Loewe's additivity (concentration addition) is a well-known model for predicting the toxic effects of chemical mixtures under the additivity assumption of toxicity. However, from the perspective of chemical risk assessment and/or management, it is important to identify chemicals whose toxicities are additive when present concurrently, that is, it should be established whether there are chemical mixtures to which the concentration addition predictive model can be applied. The objective of the present study was to develop criteria for judging test results that deviated from the predictions by the concentration addition chemical mixture model. These criteria were based on the confidence interval of the concentration addition model's prediction and on estimation of errors of the predicted concentration-effect curves by toxicity tests after exposure to single chemicals. A log-logit model with 2 parameters was assumed for the concentration-effect curve of each individual chemical. These parameters were determined by the maximum-likelihood method, and the criteria were defined using the variances and the covariance of the parameters. In addition, the criteria were applied to a toxicity test of a binary mixture of p-n-nonylphenol and p-n-octylphenol using the Japanese killifish, medaka (Oryzias latipes). Consequently, the concentration addition model using confidence interval was capable of predicting the test results at any level, and no reason for rejecting the concentration addition was found. Environ Toxicol Chem 2016;35:1806-1814. © 2015 SETAC. PMID:26660330
Weighted Wilcoxon-type Smoothly Clipped Absolute Deviation Method
Wang, Lan; Li, Runze
2009-01-01
Summary Shrinkage-type variable selection procedures have recently seen increasing applications in biomedical research. However, their performance can be adversely influenced by outliers in either the response or the covariate space. This paper proposes a weighted Wilcoxon-type smoothly clipped absolute deviation (WW-SCAD) method, which deals with robust variable selection and robust estimation simultaneously. The new procedure can be conveniently implemented with the statistical software R. We establish that the WW-SCAD correctly identifies the set of zero coefficients with probability approaching one and estimates the nonzero coefficients with the rate n−1/2. Moreover, with appropriately chosen weights the WW-SCAD is robust with respect to outliers in both the x and y directions. The important special case with constant weights yields an oracle-type estimator with high efficiency at the presence of heavier-tailed random errors. The robustness of the WW-SCAD is partly justified by its asymptotic performance under local shrinking contamination. We propose a BIC-type tuning parameter selector for the WW-SCAD. The performance of the WW-SCAD is demonstrated via simulations and by an application to a study that investigates the effects of personal characteristics and dietary factors on plasma beta-carotene level. PMID:18647294
Deviation from corresponding-states behaviour for polar fluids
NASA Astrophysics Data System (ADS)
van Leeuwen, M. E.
The influence of the strength of the reduced dipole moment μ* of a Stockmayer fluid on thermodynamic phase behaviour is systematically investigated by means of computer simulations. Gibbs ensemble simulation data are presented for Stockmayer fluids with μ*2=5 and μ*2=6 in the reduced temperature range of 0·78-0·98 (respectively 0·99). Critical properties are estimated from Gibbs ensemble Monte Carlo data. The critical temperature increases strongly with increasing dipole moment, and the critical density shows a decrease for higher dipole moment values. The critical pressure increases only slightly, with the resulting reduced compressibility factor showing a clear decreasing trend. These trends are correlated with the reduced dipole moment. The Padé approximation of perturbation theory, compared with four other theories, follows the 'exact' critical-property correlations closest. The simulation results show that dipolar forces alone are sufficient to induce a deviation from corresponding-states behaviour: with increasing reduced dipole moment, the saturated-liquid densities and enthalpies of vaporization increase.
Teaching Standard Deviation by Building from Student Invention
NASA Astrophysics Data System (ADS)
Day, James; Nakahara, Hiroko; Bonn, Doug
2010-11-01
First-year physics laboratories are often driven by a mix of goals that includes the illustration or discovery of basic physics principles and a myriad of technical skills involving specific equipment, data analysis, and report writing. The sheer number of such goals seems guaranteed to produce cognitive overload, even when highly detailed "cookbook" instructions are given. Recent studies indicate that this approach leaves students with a poor conceptual understanding of one of the most important features of laboratory physics and of the real world of science, in general: the development of an understanding of the nature of measurement and its attendant uncertainty . While students might be able to reproduce certain technical manipulations of data, as novice thinkers they lack the mental scaffolding that allows an expert to organize and apply this knowledge.2,3 Our goal is to put novices on the path to expertise, so that they will be able to transfer their knowledge to novel situations.
On the superposition principle in interference experiments.
Sinha, Aninda; H Vijay, Aravind; Sinha, Urbasi
2015-01-01
The superposition principle is usually incorrectly applied in interference experiments. This has recently been investigated through numerics based on Finite Difference Time Domain (FDTD) methods as well as the Feynman path integral formalism. In the current work, we have derived an analytic formula for the Sorkin parameter which can be used to determine the deviation from the application of the principle. We have found excellent agreement between the analytic distribution and those that have been earlier estimated by numerical integration as well as resource intensive FDTD simulations. The analytic handle would be useful for comparing theory with future experiments. It is applicable both to physics based on classical wave equations as well as the non-relativistic Schrödinger equation. PMID:25973948
On the superposition principle in interference experiments
Sinha, Aninda; H. Vijay, Aravind; Sinha, Urbasi
2015-01-01
The superposition principle is usually incorrectly applied in interference experiments. This has recently been investigated through numerics based on Finite Difference Time Domain (FDTD) methods as well as the Feynman path integral formalism. In the current work, we have derived an analytic formula for the Sorkin parameter which can be used to determine the deviation from the application of the principle. We have found excellent agreement between the analytic distribution and those that have been earlier estimated by numerical integration as well as resource intensive FDTD simulations. The analytic handle would be useful for comparing theory with future experiments. It is applicable both to physics based on classical wave equations as well as the non-relativistic Schrödinger equation. PMID:25973948
Spectral Relative Standard Deviation: A Practical Benchmark in Metabolomics
Metabolomics datasets, by definition, comprise of measurements of large numbers of metabolites. Both technical (analytical) and biological factors will induce variation within these measurements that is not consistent across all metabolites. Consequently, criteria are required to...
Voith, V L
1986-12-01
This article discusses some general principles of learning as well as possible constraints and how such principles can apply to horses. A brief review is presented of experiments that were designed to assess learning in horses. The use of behavior modification techniques to treat behavior problems in horses is discussed and several examples of the use of these techniques are provided. PMID:3492241
Hamilton's Principle for Beginners
ERIC Educational Resources Information Center
Brun, J. L.
2007-01-01
I find that students have difficulty with Hamilton's principle, at least the first time they come into contact with it, and therefore it is worth designing some examples to help students grasp its complex meaning. This paper supplies the simplest example to consolidate the learning of the quoted principle: that of a free particle moving along a…
New identification method for Hammerstein models based on approximate least absolute deviation
NASA Astrophysics Data System (ADS)
Xu, Bao-Chang; Zhang, Ying-Dan
2016-07-01
Disorder and peak noises or large disturbances can deteriorate the identification effects of Hammerstein non-linear models when using the least-square (LS) method. The least absolute deviation technique can be used to resolve this problem; however, its absolute value cannot meet the need of differentiability required by most algorithms. To improve robustness and resolve the non-differentiable problem, an approximate least absolute deviation (ALAD) objective function is established by introducing a deterministic function that exhibits the characteristics of absolute value under certain situations. A new identification method for Hammerstein models based on ALAD is thus developed in this paper. The basic idea of this method is to apply the stochastic approximation theory in the process of deriving the recursive equations. After identifying the parameter matrix of the Hammerstein model via the new algorithm, the product terms in the matrix are separated by calculating the average values. Finally, algorithm convergence is proven by applying the ordinary differential equation method. The proposed algorithm has a better robustness as compared to other LS methods, particularly when abnormal points exist in the measured data. Furthermore, the proposed algorithm is easier to apply and converges faster. The simulation results demonstrate the efficacy of the proposed algorithm.
NASA Astrophysics Data System (ADS)
Becker, Sid; Munro, Ben
2014-11-01
The subject of this study concerns viscous flow through an elastic porous matrial for which the solid matrix is capable of experiencing deformation under the influence of the flow field. The inherent challenges associated with developing experimental testing of flow in deformable porous media are largely related to the fabrication of a deformable matrix. In this study a method of media fabrication is presented that uses an indirect solid free form fabrication process combining 3D Printing with an infused Polydimethylsiloxane elastomer. This allows for the precise control of the matrix parameters: elasticity and pore geometry. The conjugate flow-media behavior is then observed in an experimental test rig which captures the global flow behavior, the local matrix deformation, and the onset of the deviation from Darcy flow at low Re. The experimental data is presented such that the results can be used for numerical validation. Dimensionless combinations of parameters are considered in the prediction of the point of deviation from Darcy flow at low Re and confirmed from the experimental data. Supported by the Marsden Fund Council from Government funding, Administered by the Royal Society of New Zealand.
A model for the transport of cuttings in highly deviated wells
Gavignet, A.A.; Sobey, I.J.
1986-01-01
At present, drilling of highly deviated wells is complicated by the possibility of the formation of a thick bed of cuttings at low flow rates. The bed of cuttings can cause large torque loads on drill pipe and can fall back around the bit resulting in a stuck bit. Previous investigators have made experimental observations which show that bed formation is characterized by a relatively rapid increase in bed thickness as either the flow rate is lowered past some critical value, or as the deviation from the vertical increases. The authors present a simple model which explains these observations. The model shows that the bed thickness is controlled by the interfacial stress caused by the different velocities of the mud and the cuttings layer. The results confirm previous observations that bed formation is relatively insensitive to mud rheology. Eccentricity of the drill pipe in the hole is an important factor. The model is used to determine critical flow rate needed to prevent the formation of a thick bed of cuttings and the inclination, hole size and rate of penetration are varied.
2012-01-01
Background and purpose Unicompartmental knee arthroplasty (UKA) is an established method of treating isolated gonartrosis. Modern techniques such as computer-assisted surgery (CAS) and minimally invasive surgery (MIS) are attractive complementary methods to UKA. However, the positioning of the components remains a concern. Thus, we performed a prospective study to assess whether there was deviation between the navigated implant position and the final implant position. Patients and methods We performed UKA with MIS and CAS in 13 patients. By comparing intraoperative navigation data with postoperative computed tomography (CT) measurements, we calculated the deviation between the computer-assisted implant position and the final 3-D implant position of the femoral and tibial components. Results The computer-assisted placement of the femoral and tibial component showed adequate position and consistent results regarding flexion-extension and varus-valgus. However, regarding rotation there was a large variation and 6 of 10 patients were outside the target range for both the femoral component and the tibial component. Interpretation Difficulties in assessing anatomical landmarks with the CAS in combination with MIS might be a reason for the poor rotational alignment of the components. PMID:23043273
Clouser, K D; Gert, B
1990-04-01
The authors use the term "principlism" to refer to the practice of using "principles" to replace both moral theory and particular moral rules and ideals in dealing with the moral problems that arise in medical practice. The authors argue that these "principles" do not function as claimed, and that their use is misleading both practically and theoretically. The "principles" are in fact not guides to action, but rather they are merely names for a collection of sometimes superficially related matters for consideration when dealing with a moral problem. The "principles" lack any systematic relationship to each other, and they often conflict with each other. These conflicts are unresolvable, since there is no unified moral theory from which they are all derived. For comparison the authors sketch the advantages of using a unified moral theory. PMID:2351895
48 CFR 2901.405 - Deviations pertaining to treaties and executive agreements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... DOLAR 2901.405 Deviations pertaining to treaties and executive agreements. (a) The Director, DAMS is... deviations not authorized by FAR 1.405(b) or (c), the Director, DAMS, will process the request for...
48 CFR 2901.405 - Deviations pertaining to treaties and executive agreements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... DOLAR 2901.405 Deviations pertaining to treaties and executive agreements. (a) The Director, DAMS is... deviations not authorized by FAR 1.405(b) or (c), the Director, DAMS, will process the request for...
32 CFR 21.340 - What are the procedures for requesting and documenting deviations?
Code of Federal Regulations, 2010 CFR
2010-07-01
... deviations and written requests for class deviations to: Deputy Director of Defense Research and Engineering, ATTN: Basic Research, 3080 Defense Pentagon, Washington, DC 20301-3080. (b) Grants officers...
32 CFR 21.340 - What are the procedures for requesting and documenting deviations?
Code of Federal Regulations, 2011 CFR
2011-07-01
... deviations and written requests for class deviations to: Deputy Director of Defense Research and Engineering, ATTN: Basic Research, 3080 Defense Pentagon, Washington, DC 20301-3080. (b) Grants officers...
Petrothermal heat extraction using a single deviated well (Horstberg, revisited)
NASA Astrophysics Data System (ADS)
Ghergut, Julia; Behrens, Horst; Vogt, Esther; Bartetzko, Anne; Sauter, Martin
2013-04-01
The single-well tracer test conducted (Behrens et al. 2006) in conjunction with waterfrac experiments at Horstberg is re-examined with a view at four basic issues: why single-well? why fracturing? why tracers? does this only work at Horstberg, or can it work almost anywhere else in the Northern-German sedimentary basin? Heat and tracer transport within a composite reservoir (impermeable matrix + waterfrac + permeable layer), as accessed by a single deviated well, turn out to fit into a surprisingly simple description, as the plain (arithmetic) sum of certain petrothermal-type and aquifer-type contributions, whose weighting relative to each other can vary from site to site, depending upon stratigraphy and upon wellbore geometry. At Horstberg, within the particular formations tested ('Volpriehausen', 'Detfurth', 'Solling', comprising mainly claystone and sandstone layers), thermal lifetime results to be petrothermally-dominated, while tracer residence times prove to be 'aquifer'-dominated. Despite this disparity, the reservoir's thermal lifetime can reliably be predicted from tracer test results. What cannot be determined from waterfrac flow-path tracing is the very waterfrac's aperture. Aperture uncertainty, however, does not impede upon thermal lifetime predictability. The results of the semi-analytical approach are confirmed by numerical simulations using a FE model that includes more details of hydrogeological heterogeneity for the Horstberg site. They are complemented by a parameter sensitivity analysis. ACKNOWLEDGEMENT: This study is funded by MWK Niedersachsen (Lower-Saxony's Science and Culture Ministry) and by Baker Hughes (Celle) within task unit G6 of the Collaborative Research Project 'gebo' ('Geothermal Energy and High-Performance Drilling').
Piezoelectric sensing: Evaluation for clinical investigation of deviated nasal septum.
Manjunatha, Roopa G; Rajanna, Konandur; Mahapatra, Roy D; Dorasala, Srinivas
2013-01-01
Noninvasive objective evaluation of nasal airflow is one of the important clinical aspects. The developed polyvinylidene fluoride (PVDF) sensor enables measurement of airflow through each side of the nose using its piezoelectric property. This study was designed to evaluate the diagnostic capability of the PVDF sensor in assessing the deviated nasal septum (DNS). PVDF nasal sensor uses its piezoelectric property to measure the peak-to-peak amplitude (Vp-p) of nasal airflow in both of the nostrils: right nostril (RN) and left nostril (LN), separately and simultaneously. We have compared the results of PVDF nasal sensor, visual analog scale (VAS), and clinician scale for 34 DNS patients and 28 healthy controls. Additionally, the results were further analyzed by receiver operating characteristic curve and correlation between PVDF nasal sensor and VAS in detecting DNS. We found a significant difference in the peak-to-peak amplitude values of the test group and the control group. The correlation between the PVDF nasal sensor measurements and VAS (RN and LN combined) for test group was statistically significant (-0.807; p < 0.001). Sensitivity and specificity of the PVDF nasal sensor measurements in the detection of DNS (RN and LN combined) was 85.3 and 74.4%, respectively, with optimum cutoff value ≤0.34 Vp-p. The developed PVDF nasal sensor is noninvasive and requires less patient efforts. The sensitivity and specificity of the PVDF nasal sensor are reliable. According to our findings, we propose that the said PVDF nasal sensor can be used as a new diagnostic tool to evaluate the DNS in routine clinical practice.
Long Term Gait Deviations in Anterior Cruciate Ligament Reconstructed Females
Noehren, Brian; Wilson, Hilary; Miller, Casey; Lattermann, Christian
2015-01-01
Purpose Little is known of the potential long term gait alterations that occur after an anterior cruciate ligament (ACL) reconstruction. In particular, variables such as impact loading which have been previously associated with joint deterioration have not been studied in walking and running after an ACL reconstruction. The purpose of this study was to define the alterations in impact forces, loading rates, and the accompanying sagittal plane kinematic and kinetic mechanics at the time of impact between the ACL reconstructed group and a healthy control group. Methods 40 females (20 ACL reconstruction, 20 controls) participated in the study. An instrumented gait analysis was performed on all subjects. Between group and limb comparisons were made for initial vertical impact force, loading rate, sagittal plane knee and hip angles as well as moments. Results During walking and running the ACL cohort had significantly greater initial vertical impact force (p=0.002 and p= 0.001), and loading rates (p=0.03 and p= 0.01), as well as a smaller knee extensor moment and hip angle during walking (p=0.000 and p=0.01). There was a trend towards a smaller knee moment and hip angle during running (p=0.08 and p=0.06) as well as a larger hip extensor moment during walking (p=0.06) in the ACL group. No differences were found for hip extensor moment during running, knee angles between groups during walking or running. Lastly, no between limb differences were found for any variable. Conclusion Gait deviations such as elevated impact loading and loading rates do not resolve long term after the individual has resumed previous activity levels and may contribute to the greater risk of early joint degeneration in this population. PMID:23568090
Piezoelectric sensing: Evaluation for clinical investigation of deviated nasal septum
Manjunatha, Roopa G.; Mahapatra, Roy D.; Dorasala, Srinivas
2013-01-01
Noninvasive objective evaluation of nasal airflow is one of the important clinical aspects. The developed polyvinylidene fluoride (PVDF) sensor enables measurement of airflow through each side of the nose using its piezoelectric property. This study was designed to evaluate the diagnostic capability of the PVDF sensor in assessing the deviated nasal septum (DNS). PVDF nasal sensor uses its piezoelectric property to measure the peak-to-peak amplitude (Vp-p) of nasal airflow in both of the nostrils: right nostril (RN) and left nostril (LN), separately and simultaneously. We have compared the results of PVDF nasal sensor, visual analog scale (VAS), and clinician scale for 34 DNS patients and 28 healthy controls. Additionally, the results were further analyzed by receiver operating characteristic curve and correlation between PVDF nasal sensor and VAS in detecting DNS. We found a significant difference in the peak-to-peak amplitude values of the test group and the control group. The correlation between the PVDF nasal sensor measurements and VAS (RN and LN combined) for test group was statistically significant (−0.807; p < 0.001). Sensitivity and specificity of the PVDF nasal sensor measurements in the detection of DNS (RN and LN combined) was 85.3 and 74.4%, respectively, with optimum cutoff value ≤0.34 Vp-p. The developed PVDF nasal sensor is noninvasive and requires less patient efforts. The sensitivity and specificity of the PVDF nasal sensor are reliable. According to our findings, we propose that the said PVDF nasal sensor can be used as a new diagnostic tool to evaluate the DNS in routine clinical practice. PMID:24498519
The Principle of Energetic Consistency
NASA Technical Reports Server (NTRS)
Cohn, Stephen E.
2009-01-01
A basic result in estimation theory is that the minimum variance estimate of the dynamical state, given the observations, is the conditional mean estimate. This result holds independently of the specifics of any dynamical or observation nonlinearity or stochasticity, requiring only that the probability density function of the state, conditioned on the observations, has two moments. For nonlinear dynamics that conserve a total energy, this general result implies the principle of energetic consistency: if the dynamical variables are taken to be the natural energy variables, then the sum of the total energy of the conditional mean and the trace of the conditional covariance matrix (the total variance) is constant between observations. Ensemble Kalman filtering methods are designed to approximate the evolution of the conditional mean and covariance matrix. For them the principle of energetic consistency holds independently of ensemble size, even with covariance localization. However, full Kalman filter experiments with advection dynamics have shown that a small amount of numerical dissipation can cause a large, state-dependent loss of total variance, to the detriment of filter performance. The principle of energetic consistency offers a simple way to test whether this spurious loss of variance limits ensemble filter performance in full-blown applications. The classical second-moment closure (third-moment discard) equations also satisfy the principle of energetic consistency, independently of the rank of the conditional covariance matrix. Low-rank approximation of these equations offers an energetically consistent, computationally viable alternative to ensemble filtering. Current formulations of long-window, weak-constraint, four-dimensional variational methods are designed to approximate the conditional mode rather than the conditional mean. Thus they neglect the nonlinear bias term in the second-moment closure equation for the conditional mean. The principle of
Principles for system level electrochemistry
NASA Technical Reports Server (NTRS)
Thaller, L. H.
1986-01-01
The higher power and higher voltage levels anticipated for future space missions have required a careful review of the techniques currently in use to preclude battery problems that are related to the dispersion characteristics of the individual cells. Not only are the out-of-balance problems accentuated in these larger systems, but the thermal management considerations also require a greater degree of accurate design. Newer concepts which employ active cooling techniques are being developed which permit higher rates of discharge and tighter packing densities for the electrochemical components. This paper will put forward six semi-independent principles relating to battery systems. These principles will progressively address cell, battery and finally system related aspects of large electrochemical storage systems.
[Genetics and the precautionary principle].
Rosa, J
2000-01-01
It is very important to follow the Precautionary Principles with regard to genetics because of its fast development and of its impact in the public imaginer. In that regard gene grafts, OGM or recombinant drugs are pre-eminently be suspected to transmit human or animal viruses and/or to induce severe allergies. Pharmaceutical Industry has conducted large reflexions on such problems and are using drastic rules to prevent them. By contrast, academic research laboratories are handicapped by the problem of fund seeking. At the genetic disease level and mainly because the fast development of Predictive Medicine, patient and family councelling requires a great lot of reflexion and carefulness. Memorization of the presence of abnormal genes in the history of families also constitutes an important problem. We believe that, to be in accordance with the Precautionary Principles, an important work of formation and information is required.
7 CFR 400.174 - Notification of deviation from financial standards.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 6 2010-01-01 2010-01-01 false Notification of deviation from financial standards... Agreement-Standards for Approval; Regulations for the 1997 and Subsequent Reinsurance Years § 400.174 Notification of deviation from financial standards. An insurer must immediately advise FCIC if it deviates...
1 CFR 21.14 - Deviations from standard organization of the Code of Federal Regulations.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 1 General Provisions 1 2010-01-01 2010-01-01 false Deviations from standard organization of the... CODIFICATION General Numbering § 21.14 Deviations from standard organization of the Code of Federal Regulations. (a) Any deviation from standard Code of Federal Regulations designations must be approved in...
Relation Between ITPA Average Deviation and Stanford-Binet Intelligence Scores
ERIC Educational Resources Information Center
Burns, Edward
1976-01-01
The relation between average deviation, as determined using the Illinois Test of Psycholinguistic Abilities, and Stanford-Binet intelligence scores was examined using a preschool sample. Results revealed a curvilinear relation between total average deviation and Stanford-Binet intelligence scores. Use of average deviation as an index of "learning…
A Principled Approach to the Origin Problem.
Aono, Masashi; Kitadai, Norio; Oono, Yoshi
2015-09-01
The key issue of the origin of life is the origin of a complex system rather than the abiotic formation of various organic substances, small and large. To consider this "origin problem" it is advantageous to abstract some principles from biology and statistical physics to guide our approach. Referring to these principles, we aim to construct a chemical system called "protometabolism," which would be a precursor of metabolism.
Deviations from tribimaximal neutrino mixing using a model with Δ(27) symmetry
NASA Astrophysics Data System (ADS)
Harrison, P. F.; Krishnan, R.; Scott, W. G.
2014-07-01
We present a model of neutrino mixing based on the flavor group Δ(27) in order to account for the observation of a nonzero reactor mixing angle (θ13). The model provides a common flavor structure for the charged-lepton and the neutrino sectors, giving their mass matrices a "circulant-plus-diagonal" form. Mass matrices of this form readily lead to mixing patterns with realistic deviations from tribimaximal mixing, including nonzero θ13. With the parameters constrained by existing measurements, our model predicts an inverted neutrino mass hierarchy. We obtain two distinct sets of solutions in which the atmospheric mixing angle lies in the first and the second octants. The first (second) octant solution predicts the lightest neutrino mass, m3 29 meV(m3 65 meV) and the CP phase, δ CP ˜-(π )/(4) (δ CP ˜(π )/(2)), offering the possibility of large observable CP violating effects in future experiments.
What Metadata Principles Apply to Scientific Data?
NASA Astrophysics Data System (ADS)
Mayernik, M. S.
2014-12-01
Information researchers and professionals based in the library and information science fields often approach their work through developing and applying defined sets of principles. For example, for over 100 years, the evolution of library cataloging practice has largely been driven by debates (which are still ongoing) about the fundamental principles of cataloging and how those principles should manifest in rules for cataloging. Similarly, the development of archival research and practices over the past century has proceeded hand-in-hand with the emergence of principles of archival arrangement and description, such as maintaining the original order of records and documenting provenance. This project examines principles related to the creation of metadata for scientific data. The presentation will outline: 1) how understandings and implementations of metadata can range broadly depending on the institutional context, and 2) how metadata principles developed by the library and information science community might apply to metadata developments for scientific data. The development and formalization of such principles would contribute to the development of metadata practices and standards in a wide range of institutions, including data repositories, libraries, and research centers. Shared metadata principles would potentially be useful in streamlining data discovery and integration, and would also benefit the growing efforts to formalize data curation education.
NASA Astrophysics Data System (ADS)
Hartmann, Peter
2015-10-01
The design of high-quality imaging lenses continues to strive for the best color trueness over wider and wider wavelength ranges such as for multiwavelength fluorescence microscopy or hyperspectral imaging. Glasses suitable for sharp images at more than two wavelengths must differ in their dispersion from the classical crown and flint glass types, which gather along a straight line in a plot of the relative partial dispersion against the Abbe number. Glasses suitable for multicolor correction can be recognized by a considerable deviation of their relative partial dispersion from this normal line. Originally, the normal lines for different relative partial dispersions were defined by using the SCHOTT glass types K7 and F2. Today's data sheets of all glass manufacturers contain numerical values for deviations of relative partial dispersions from the normal lines. A comparison of almost identical glasses shows differences between these deviations being too large, obviously coming from different versions of K7 and F2 dispersion curves used. For preselection in designs and for direct comparison of glass types, it is necessary to agree on common dispersion curves each for K7 and for F2 in order to obtain really comparable values for deviations of the relative partial dispersion from the normal line.
Deviation of permeable coarse-grained boundary resistance from Nikuradse's observations
NASA Astrophysics Data System (ADS)
Cheng, Nian-Sheng; Liu, Xingnian; Chen, Xingwei; Qiao, Changkai
2016-02-01
Nikuradse's (1933) rough pipe study is enormously influential in the understanding of flow resistance over a sediment bed. However, the rough boundary employed in Nikuradse's study differs from permeable sediment beds in rivers. This implies that the results derived from the rough pipe experiments may not be applicable for flows over a permeable coarse-grained bed. The present study aimed to explore to what extent the flow resistance of a permeable coarse-grained boundary deviates from the Nikuradse's observations. Experiments were conducted with rough pipes, which were prepared by overlaying the inner wall with one to four layers of spherical beads. The single layer roughness resembles the experimental setup reported in Nikuradse's study, while the multilayer of grains allows significant flow to pass through the porous roughness layer. In addition, the ratio of grain diameter, k, to pipe diameter, d, was chosen to be one to two orders greater than the range (0.001 < k/d < 0.033) adopted in Nikuradse's experiments. The data show that the friction factor deviates significantly from the prediction based on Nikuradse's rough pipe relation. For hydraulically rough pipes, the friction factor is found to be proportional to the squared ratio of the grain diameter to nominal pipe diameter. This result is different from the one-third power function as implied by Nikuradse's rough pipe relation or the Manning-Strickler formula but agrees well with laboratory observations of open channel resistance in the presence of large-scale roughness. The measurements also suggest the existence of a laminar flow regime, in which the friction factor is inversely proportional to the Reynolds number. The observed variations in the flow resistance are attributed to both wall permeability and large-scale roughness.
Staggs, Vincent S
2016-10-01
It is widely thought that low staffing levels are associated with higher risk of psychiatric inpatient violence. The purpose of this study was to determine whether odds of an injurious assault are higher in months in which unit staffing levels are higher or lower relative to unit average, using a design allowing each unit to serve as its own control. Using 2011-2013 National Database of Nursing Quality Indicators data from 480 adult and 90 geriatric units in 361 US hospitals, monthly assault odds were modeled as functions of unit staffing. Monthly RN and non-RN staffing (hours per patient day) were categorized as very low, low, average, high, or very high, based on deviation from the unit's average staffing across study months. Endpoints were binary indicators for one or more injurious assaults against staff during the month and for one or more injurious assaults against patients during the month. Despite large sample sizes, neither RN nor non-RN staffing was a statistically significant predictor of odds of assault, nor was there a consistent trend of odds of assault being higher at below- or above-average staffing levels. There was little evidence that monthly deviation in unit staffing is associated with the odds of an injurious assault on a unit. This suggests that staffing-assault rate associations in previous studies of monthly data are largely attributable to between-unit rather than within-unit staffing differences. Hospitals may need to look beyond below- or above-average nurse staffing as a cause of assaults. © 2016 Wiley Periodicals, Inc. PMID:27304990
Staggs, Vincent S
2016-10-01
It is widely thought that low staffing levels are associated with higher risk of psychiatric inpatient violence. The purpose of this study was to determine whether odds of an injurious assault are higher in months in which unit staffing levels are higher or lower relative to unit average, using a design allowing each unit to serve as its own control. Using 2011-2013 National Database of Nursing Quality Indicators data from 480 adult and 90 geriatric units in 361 US hospitals, monthly assault odds were modeled as functions of unit staffing. Monthly RN and non-RN staffing (hours per patient day) were categorized as very low, low, average, high, or very high, based on deviation from the unit's average staffing across study months. Endpoints were binary indicators for one or more injurious assaults against staff during the month and for one or more injurious assaults against patients during the month. Despite large sample sizes, neither RN nor non-RN staffing was a statistically significant predictor of odds of assault, nor was there a consistent trend of odds of assault being higher at below- or above-average staffing levels. There was little evidence that monthly deviation in unit staffing is associated with the odds of an injurious assault on a unit. This suggests that staffing-assault rate associations in previous studies of monthly data are largely attributable to between-unit rather than within-unit staffing differences. Hospitals may need to look beyond below- or above-average nurse staffing as a cause of assaults. © 2016 Wiley Periodicals, Inc.
Trillo, Y; Lago, A; Silva-Del-Río, N
2016-07-01
Nutrient composition of the feed and formulated ration often differ depending on uncertainties in DM content and nutrient composition of ingredients, as well as from feeder errors during loading. The objective of this study was to describe the deviation from target weight for the high-producing cow ration (HCR) and premix (HCP) on 26 California dairies ranging in size from 1,100 to 6,900 cows. Records from a consecutive 12-mo period were extracted from FeedWatch 7 (Valley Agricultural Software Inc., Tulare, CA), a feeding management software. Variables extracted and studied were date, recipe type, recipe number, ingredient, loading sequence, target weight, weight, and tolerance level (TL, deviation allowed per ingredient during loading). Based on the distribution of the deviation from target weight for the 8 most common ingredients, loading accuracy (quartile 1; small: |<10| kg; medium |10| to |20| kg; large |>20| kg), loading precision (interquartile range=quartile 3 to 1; small: <20kg; medium: 20 to 40kg; large >40kg), and extreme observations (quartile 3; small: |<25| kg; medium: |25| to |40| kg; large: |>40| kg) were described. Descriptive statistics were conducted with SAS 9.4 (SAS Institute Inc., Cary, NC). The median TL assigned to ingredients across dairies ranged from 0 to 90kg. At the ingredient level, the TL allowed a deviation from the median ingredient target weight of 0 to 2 (53.9%), >2 to 5 (25.5%), >5 to 10 (11.6%), or >10% (8.9%). A total of 2.5% of the loads did not reach the target weight set by the TL, ranging from 0.1 to 21.1% loads across dairies. Ingredient deviation from the formulated target weight across dairies was below target 49.1% of the time [<-10 (2.5%), -10 to <-5 (4.8%), -5 to <-2 (8.9%), -2 to <0% (32.8%)] or at or above target 50.9% of the time [0 (3.9%), >0 to 2 (36.7%), >2 to 5 (8.9%), >5 to 10 (1.2%), >10% (0.2%)]. Five dairies loaded ingredients with adequate accuracy (small to medium, quartile 1) and adequate precision
Trillo, Y; Lago, A; Silva-Del-Río, N
2016-07-01
Nutrient composition of the feed and formulated ration often differ depending on uncertainties in DM content and nutrient composition of ingredients, as well as from feeder errors during loading. The objective of this study was to describe the deviation from target weight for the high-producing cow ration (HCR) and premix (HCP) on 26 California dairies ranging in size from 1,100 to 6,900 cows. Records from a consecutive 12-mo period were extracted from FeedWatch 7 (Valley Agricultural Software Inc., Tulare, CA), a feeding management software. Variables extracted and studied were date, recipe type, recipe number, ingredient, loading sequence, target weight, weight, and tolerance level (TL, deviation allowed per ingredient during loading). Based on the distribution of the deviation from target weight for the 8 most common ingredients, loading accuracy (quartile 1; small: |<10| kg; medium |10| to |20| kg; large |>20| kg), loading precision (interquartile range=quartile 3 to 1; small: <20kg; medium: 20 to 40kg; large >40kg), and extreme observations (quartile 3; small: |<25| kg; medium: |25| to |40| kg; large: |>40| kg) were described. Descriptive statistics were conducted with SAS 9.4 (SAS Institute Inc., Cary, NC). The median TL assigned to ingredients across dairies ranged from 0 to 90kg. At the ingredient level, the TL allowed a deviation from the median ingredient target weight of 0 to 2 (53.9%), >2 to 5 (25.5%), >5 to 10 (11.6%), or >10% (8.9%). A total of 2.5% of the loads did not reach the target weight set by the TL, ranging from 0.1 to 21.1% loads across dairies. Ingredient deviation from the formulated target weight across dairies was below target 49.1% of the time [<-10 (2.5%), -10 to <-5 (4.8%), -5 to <-2 (8.9%), -2 to <0% (32.8%)] or at or above target 50.9% of the time [0 (3.9%), >0 to 2 (36.7%), >2 to 5 (8.9%), >5 to 10 (1.2%), >10% (0.2%)]. Five dairies loaded ingredients with adequate accuracy (small to medium, quartile 1) and adequate precision
Archimedes' Principle in Action
ERIC Educational Resources Information Center
Kires, Marian
2007-01-01
The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers. (Contains 5 figures.)
Chemical Principles Exemplified
ERIC Educational Resources Information Center
Plumb, Robert C.
1972-01-01
Collection of two short descriptions of chemical principles seen in life situations: the autocatalytic reaction seen in the bombardier beetle, and molecular potential energy used for quick roasting of beef. Brief reference is also made to methanol lighters. (PS)
Archimedes' principle in action
NASA Astrophysics Data System (ADS)
Kireš, Marián
2007-09-01
The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers.
Principles of Tendon Transfer.
Wilbur, Danielle; Hammert, Warren C
2016-08-01
Tendon transfers provide a substitute, either temporary or permanent, when function is lost due to neurologic injury in stroke, cerebral palsy or central nervous system lesions, peripheral nerve injuries, or injuries to the musculotendinous unit itself. This article reviews the basic principles of tendon transfer, which are important when planning surgery and essential for an optimal outcome. In addition, concepts for coapting the tendons during surgery and general principles to be followed during the rehabilitation process are discussed. PMID:27387072
The Stanford equivalence principle program
NASA Technical Reports Server (NTRS)
Worden, Paul W., Jr.; Everitt, C. W. Francis; Bye, M.
1989-01-01
The Stanford Equivalence Principle Program (Worden, Jr. 1983) is intended to test the uniqueness of free fall to the ultimate possible accuracy. The program is being conducted in two phases: first, a ground-based version of the experiment, which should have a sensitivity to differences in rate of fall of one part in 10(exp 12); followed by an orbital experiment with a sensitivity of one part in 10(exp 17) or better. The ground-based experiment, although a sensitive equivalence principle test in its own right, is being used for technology development for the orbital experiment. A secondary goal of the experiment is a search for exotic forces. The instrument is very well suited for this search, which would be conducted mostly with the ground-based apparatus. The short range predicted for these forces means that forces originating in the Earth would not be detectable in orbit. But detection of Yukawa-type exotic forces from a nearby large satellite (such as Space Station) is feasible, and gives a very sensitive and controllable test for little more effort than the orbiting equivalence principle test itself.
Babinet's principle for optical frequency metamaterials and nanoantennas
NASA Astrophysics Data System (ADS)
Zentgraf, T.; Meyrath, T. P.; Seidel, A.; Kaiser, S.; Giessen, H.; Rockstuhl, C.; Lederer, F.
2007-07-01
We consider Babinet’s principle for metamaterials at optical frequencies and include realistic conditions which deviate from the theoretical assumptions of the classic principle such as an infinitely thin and perfectly conducting metal layer. It is shown that Babinet’s principle associates not only transmission and reflection between a structure and its complement but also the field modal profiles of the electromagnetic resonances as well as effective material parameters—a critical concept for metamaterials. Also playing an important role in antenna design, Babinet’s principle is particularly interesting to consider in this case where the metasurfaces and their complements can be regarded as variations on a folded dipole antenna array and patch antenna array, respectively.
Deviations from Boltzmann-Gibbs Statistics in Confined Optical Lattices
NASA Astrophysics Data System (ADS)
Dechant, Andreas; Kessler, David A.; Barkai, Eli
2015-10-01
We investigate the semiclassical phase-space probability distribution P (x ,p ) of cold atoms in a Sisyphus cooling lattice with an additional harmonic confinement. We pose the question of whether this nonequilibrium steady state satisfies the equivalence of energy and probability. This equivalence is the foundation of Boltzmann-Gibbs and generalized thermostatic statistics, and a prerequisite for the description in terms of a temperature. At large energies, P (x ,p ) depends only on the Hamiltonian H (x ,p ) and the answer to the question is yes. In distinction to the Boltzmann-Gibbs state, the large-energy tails are power laws P (x ,p )∝H (x ,p )-1/D, where D is related to the depth of the optical lattice. At intermediate energies, however, P (x ,p ) cannot be expressed as a function of the Hamiltonian and the equivalence between energy and probability breaks down. As a consequence the average potential and kinetic energy differ and no well-defined temperature can be assigned. The Boltzmann-Gibbs state is regained only in the limit of deep optical lattices. For strong confinement relative to the damping, we derive an explicit expression for the stationary phase-space distribution.
The traveltime holographic principle
NASA Astrophysics Data System (ADS)
Huang, Yunsong; Schuster, Gerard T.
2015-01-01
Fermat's interferometric principle is used to compute interior transmission traveltimes τpq from exterior transmission traveltimes τsp and τsq. Here, the exterior traveltimes are computed for sources s on a boundary B that encloses a volume V of interior points p and q. Once the exterior traveltimes are computed, no further ray tracing is needed to calculate the interior times τpq. Therefore this interferometric approach can be more efficient than explicitly computing interior traveltimes τpq by ray tracing. Moreover, the memory requirement of the traveltimes is reduced by one dimension, because the boundary B is of one fewer dimension than the volume V. An application of this approach is demonstrated with interbed multiple (IM) elimination. Here, the IMs in the observed data are predicted from the migration image and are subsequently removed by adaptive subtraction. This prediction is enabled by the knowledge of interior transmission traveltimes τpq computed according to Fermat's interferometric principle. We denote this principle as the `traveltime holographic principle', by analogy with the holographic principle in cosmology where information in a volume is encoded on the region's boundary.
Maiorov, V N; Crippen, G M
1994-01-14
In the study of globular protein conformations, one customarily measures the similarity in three-dimensional structure by the root-mean-square deviation (RMSD) of the C alpha atomic coordinates after optimal rigid body superposition. Even when the two protein structures each consist of a single chain having the same number of residues so that the matching of C alpha atoms is obvious, it is not clear how to interpret the RMSD. A very large value means they are dissimilar, and zero means they are identical in conformation, but at what intermediate values are they particularly similar or clearly dissimilar? While many workers in the field have chosen arbitrary cutoffs, and others have judged values of RMSD according to the observed distribution of RMSD for random structures, we propose a self-referential, non-statistical standard. We take two conformers to be intrinsically similar if their RMSD is smaller than that when one of them is mirror inverted. Because the structures considered here are not arbitrary configurations of point atoms, but are compact, globular, polypeptide chains, our definition is closely related to similarity in radius of gyration and overall chain folding patterns. Being strongly similar in our sense implies that the radii of gyration must be nearly identical, the root-mean-square deviation in interatomic distances is linearly related to RMSD, and the two chains must have the same general fold. Only when the RMSD exceeds this level can parts of the polypeptide chain undergo nontrivial rearrangements while remaining globular. This enables us to judge when a prediction of a protein's conformation is "correct except for minor perturbations", or when the ensemble of protein structures deduced from NMR experiments are "basically in mutual agreement". PMID:8289285
Robertson, Alan; Hill, William G.
1984-01-01
An analysis is made of the distribution of deviations from Hardy-Weinberg proportions with k alleles and of estimates of inbreeding coefficients (f) obtained from these deviations.—If f is small, the best estimate of f in large samples is shown to be 2Σ i(Tii/Ni)/(k - 1), where Tii is an unbiased measure of the excess of the ith homozygote and Ni the number of the ith allele in the sample [frequency = Ni/(2N)]. No extra information is obtained from the Tij, where these are departures of numbers of heterozygotes from expectation. Alternatively, the best estimator can be computed from the Tij, ignoring the Tii. Also (1) the variance of the estimate of f equals 1/(N(k - 1)) when all individuals in the sample are unrelated, and the test for f = 0 with 1 d.f. is given by the ratio of the estimate to its standard error; (2) the variance is reduced if some alleles are rare; and (3) if the sample consists of full-sib families of size n, the variance is increased by a proportion (n - 1)/4 but is not increased by a half-sib relationship.—If f is not small, the structure of the population is of critical importance. (1) If the inbreeding is due to a proportion of inbred matings in an otherwise random-breeding population, f as determined from homozygote excess is the same for all genes and expressions are given for its sampling variance. (2) If the homozygote excess is due to population admixture, f is not the same for all genes. The above estimator is probably close to the best for all f values. PMID:6745643
Baharoglu, Merih I; Lauric, Alexandra; Wu, Chengyuan; Hippelheuser, James; Malek, Adel M
2014-10-17
Cerebral aneurysms form preferentially at arterial bifurcations. The vascular optimality principle (VOP) decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent (r₀) and daughter branches (r1 and r2): r₀(n)=r₁(n)+r₂(n), with n approximating three. VOP entails constant wall shear stress (WSS), an endothelial phenotype regulator. We sought to determine if caliber control is maintained in aneurysmal intracranial bifurcations. Three-dimensional rotational angiographic volumes of 159 middle cerebral artery (MCA) bifurcations (62 aneurysmal) were processed using 3D gradient edge-detection filtering, enabling threshold-insensitive radius measurement. Radius ratio (RR)=r₀(3)/(r₁(3)+r₂(3)) and estimated junction exponent (n) were compared between aneurysmal and non-aneurysmal bifurcations using Student t-test and Wilcoxon rank-sum analysis. The results show that non-aneurysmal bifurcations display optimal caliber control with mean RR of 1.05 and median n of 2.84. In contrast, aneurysmal bifurcations had significantly lower RR (0.76, p<.0001) and higher n (4.28, p<.0001). Unexpectedly, 37% of aneurysmal bifurcations revealed a daughter branch larger than its parent vessel, an absolute violation of optimality, not witnessed in non-aneurysmal bifurcations. The aneurysms originated more often off the smaller daughter (52%) vs. larger daughter branch (16%). Aneurysm size was not statistically correlated to RR or n. Aneurysmal males showed higher deviation from VOP. Non-aneurysmal MCA bifurcations contralateral to aneurysmal ones showed optimal caliber control. Aneurysmal bifurcations, in contrast to non-aneurysmal counterparts, disobey the VOP and may exhibit dysregulation in WSS-mediated caliber control. The mechanism of this focal divergence from optimality may underlie aneurysm pathogenesis and requires further study.
Spaceborne receivers: Basic principles
NASA Technical Reports Server (NTRS)
Stacey, J. M.
1984-01-01
The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.
A Correlational Study of Scoliosis and Trunk Balance in Adult Patients with Mandibular Deviation
Yang, Yang; Wang, Na; Wang, Wenyong; Ding, Yin; Sun, Shiyao
2013-01-01
Previous studies have confirmed that patients with mandibular deviation often have abnormal morphology of their cervical vertebrae. However, the relationship between mandibular deviation, scoliosis, and trunk balance has not been studied. Currently, mandibular deviation is usually treated as a single pathology, which leads to poor clinical efficiency. We investigated the relationship of spine coronal morphology and trunk balance in adult patients with mandibular deviation, and compared the finding to those in healthy volunteers. 35 adult patients with skeletal mandibular deviation and 10 healthy volunteers underwent anterior X-ray films of the head and posteroanterior X-ray films of the spine. Landmarks and lines were drawn and measured on these films. The axis distance method was used to measure the degree of scoliosis and the balance angle method was used to measure trunk balance. The relationship of mandibular deviation, spine coronal morphology and trunk balance was evaluated with the Pearson correlation method. The spine coronal morphology of patients with mandibular deviation demonstrated an “S” type curve, while a straight line parallel with the gravity line was found in the control group (significant difference, p<0.01). The trunk balance of patients with mandibular deviation was disturbed (imbalance angle >1°), while the control group had a normal trunk balance (imbalance angle <1°). There was a significant difference between the two groups (p<0.01). The degree of scoliosis and shoulder imbalance correlated with the degree of mandibular deviation, and presented a linear trend. The direction of mandibular deviation was the same as that of the lateral bending of thoracolumbar vertebrae, which was opposite to the direction of lateral bending of cervical vertebrae. Our study shows the degree of mandibular deviation has a high correlation with the degree of scoliosis and trunk imbalance, all the three deformities should be clinically evaluated in the
NASA Technical Reports Server (NTRS)
Hankins, D. B.; Wake, W. H.
1981-01-01
The potential remote sensing user community is enormous, and the teaching and training tasks are even larger; however, some underlying principles may be synthesized and applied at all levels from elementary school children to sophisticated and knowledgeable adults. The basic rules applying to each of the six major elements of any training course and the underlying principle involved in each rule are summarized. The six identified major elements are: (1) field sites for problems and practice; (2) lectures and inside study; (3) learning materials and resources (the kit); (4) the field experience; (5) laboratory sessions; and (6) testing and evaluation.
Itch Management: General Principles.
Misery, Laurent
2016-01-01
Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental. PMID:27578069
Itch Management: General Principles.
Misery, Laurent
2016-01-01
Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental.
Deviations in cortex sulcation associated with visual hallucinations in schizophrenia.
Cachia, A; Amad, A; Brunelin, J; Krebs, M-O; Plaze, M; Thomas, P; Jardri, R
2015-09-01
Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a recent review reported a 27% mean prevalence of VH in schizophrenia patients. The pathophysiology underlying VH in schizophrenia remains elusive. Several schizophrenia studies reported a significant effect of age on VH; therefore, we tested the hypothesis that the neurodevelopmental model of schizophrenia may explain VH occurrence. We analyzed cortex sulcation, a marker of brain development, in healthy controls (HCs) and two subgroups of carefully selected schizophrenia patients suffering from hallucinations: patients with only AH (that is, patients who never reported VH) and patients with audio-visual hallucinations (A+VH). Different cortical sulcation and left-right sulcal asymmetry were found between A+VH and AH patients, with decreased sulcation in both A+VH and AH patients in comparison with the HCs. Although a specific association between VH and neurodegenerative mechanisms, for example, in Body-Lewy Dementia or Parkinson's Disease, has previously been reported in the literature, the current study provides the first neuroimaging evidence of an association between VH and neurodevelopmental mechanisms.
Nonlinear elastic effects on the energy flux deviation of ultrasonic waves in gr/ep composites
NASA Technical Reports Server (NTRS)
Prosser, William H.; Kriz, R. D.; Fitting, Dale W.
1992-01-01
The effects of nonlinear elasticity on energy flux deviation in undirectional gr/ep composites are examined. The shift in the flux deviation is modeled using acoustoelasticity theory and the second- and third-order elastic stiffness coefficients for T300/5208 gr/ep. Two conditions of applied uniaxial stress are considered. In the first case, the direction of applied uniaxial stress was along the fiber axis (x3), while in the second case it was perpendicular to the fiber axis along the laminate stacking direction (x1). For both conditions, the change in the energy flux deviation angle from the condition of zero applied stress is computed over the range of propagation directions of 0 to 60 deg from the fiber axis at two-degree intervals. A positive flux deviation angle implies the energy deviates away from the fiber direction toward the x1 axis, while a negative deviation means that the energy deviates toward the fibers. Over this range of fiber orientation angles, the energy of the quasi-longitudinal and pure mode transverse waves deviates toward the fibers, while that of the quasi-transverse mode deviates away from the fibers.
Minimization of deviations of gear real tooth surfaces determined by coordinate measurements
NASA Technical Reports Server (NTRS)
Litvin, F. L.; Kuan, C.; Wang, J.-C.; Handschuh, R. F.; Masseth, J.; Maruyama, N.
1992-01-01
The deviations of a gear's real tooth surface from the theoretical surface are determined by coordinate measurements at the grid of the surface. A method was developed to transform the deviations from Cartesian coordinates to those along the normal at the measurement locations. Equations are derived that relate the first order deviations with the adjustment to the manufacturing machine-tool settings. The deviations of the entire surface are minimized. The minimization is achieved by application of the least-square method for an overdetermined system of linear equations. The proposed method is illustrated with a numerical example for hypoid gear and pinion.
The August Krogh principle applies to plants
NASA Technical Reports Server (NTRS)
Wayne, R.; Staves, M. P.
1996-01-01
The Krogh principle refers to the use of a large number of animals to study the large number of physiological problems, rather than limiting study to a particular organism for all problems. There may be organisms that are more suited to study of a particular problem than others. This same principle applies to plants. The authors are concerned with the recent trend in plant biology of using Arabidopsis thaliana as the "organism of choice." Arabidopsis is an excellent organism for molecular genetic research, but other plants are superior models for other research areas of plant biology. The authors present examples of the successful use of the Krogh principle in plant cell biology research, emphasizing the particular characteristics of the selected research organisms that make them the appropriate choice.
Principles of sound ecotoxicology.
Harris, Catherine A; Scott, Alexander P; Johnson, Andrew C; Panter, Grace H; Sheahan, Dave; Roberts, Mike; Sumpter, John P
2014-03-18
We have become progressively more concerned about the quality of some published ecotoxicology research. Others have also expressed concern. It is not uncommon for basic, but extremely important, factors to apparently be ignored. For example, exposure concentrations in laboratory experiments are sometimes not measured, and hence there is no evidence that the test organisms were actually exposed to the test substance, let alone at the stated concentrations. To try to improve the quality of ecotoxicology research, we suggest 12 basic principles that should be considered, not at the point of publication of the results, but during the experimental design. These principles range from carefully considering essential aspects of experimental design through to accurately defining the exposure, as well as unbiased analysis and reporting of the results. Although not all principles will apply to all studies, we offer these principles in the hope that they will improve the quality of the science that is available to regulators. Science is an evidence-based discipline and it is important that we and the regulators can trust the evidence presented to us. Significant resources often have to be devoted to refuting the results of poor research when those resources could be utilized more effectively.
ERIC Educational Resources Information Center
Kamat, R. V.
1991-01-01
A principle is presented to show that, if the time of passage of light is expressible as a function of discrete variables, one may dispense with the more general method of the calculus of variations. The calculus of variations and the alternative are described. The phenomenon of mirage is discussed. (Author/KR)
ERIC Educational Resources Information Center
Rosen, Joe
1981-01-01
Discusses the meaning of symmetry of the laws of physics and symmetry of the universe and the connection between symmetries and asymmetries of the laws of physics and those of the universe. An explanation of Hamilton's principle is offered. The material is suitable for informal discussions with students. (Author/SK)
ERIC Educational Resources Information Center
Martz, Carlton
1999-01-01
This issue of "Bill of Rights in Action" looks at individuals who have stood on principle against authority or popular opinion. The first article investigates John Adams and his defense of British soldiers at the Boston Massacre trials. The second article explores Archbishop Thomas Becket's fatal conflict with England's King Henry II. The final…
2000-01-01
The Denver principles articulate the self empowerment movement of People With AIDS (PWA). The statements, written in 1983 by the Advisory Committee of the People With AIDS, include recommendations on how to support those with disease. It also includes suggestions for people who have AIDS. It concludes by listing the "rights of people with AIDS."
Reprographic Principles Made Easy.
ERIC Educational Resources Information Center
Young, J. B.
Means for reproducing graphic materials are explained. There are several types of processes: those using light sensitive material, those using heat sensitive material, those using photo conductive materials (electrophotography), and duplicating processes using ink. For each of these, the principles behind them are explained, the necessary…
Principles of Biomedical Ethics
Athar, Shahid
2012-01-01
In this presentation, I will discuss the principles of biomedical and Islamic medical ethics and an interfaith perspective on end-of-life issues. I will also discuss three cases to exemplify some of the conflicts in ethical decision-making. PMID:23610498
Principles of Teaching. Module.
ERIC Educational Resources Information Center
Rhoades, Joseph W.
This module on principles of teaching is 1 in a series of 10 modules written for vocational education teacher education programs. It is designed to enable the teacher to do the following: (1) identify subject matter and integrate that subject matter with thought-provoking questions; (2) organize and demonstrate good questioning techniques; and (3)…
Basic Comfort Heating Principles.
ERIC Educational Resources Information Center
Dempster, Chalmer T.
The material in this beginning book for vocational students presents fundamental principles needed to understand the heating aspect of the sheet metal trade and supplies practical experience to the student so that he may become familiar with the process of determining heat loss for average structures. Six areas covered are: (1) Background…
Hydrogen evolution: Guiding principles
NASA Astrophysics Data System (ADS)
Xia, Zhenhai
2016-10-01
Lower-cost alternatives to platinum electrocatalysts are being explored for the sustainable production of hydrogen, but often trial-and-error approaches are used for their development. Now, principles are elucidated that suggest pathways to rationally design efficient metal-free electrocatalysts based on doped graphene.
Design Principles of the ESCOT Math Environments.
ERIC Educational Resources Information Center
Underwood, Jody S.; Hoadley, Chris; DiGiano, Chris; Stohl, Hollylynne; Hollebrands, Karen
This paper describes the Educational Software Components of Tomorrow (ESCOT) project. The focus of the project was on principles that support problem-solving and learner-centered design issues, and the purpose was to garner lessons from a large educational software development project to share with the learning sciences and other interested…
Comprehensive Program Review: Applying TQM Principles.
ERIC Educational Resources Information Center
Ostroth, D. David
1996-01-01
Reviews one system successfully used to implement Total Quality Management (TQM) principles and techniques in a student affairs department at a large public university. Discusses TQM applications and argues that implementation of TQM requires both planned staff training and an organization-wide culture change. (RJM)
Chambers, David W
2008-01-01
This essay presents an alternative to the traditional view that ethics means judging individual behavior against standards of right and wrong. Instead, ethics is understood as creating ethical communities through the promises we make to each other. The "aim" of ethics is to demonstrate in our own behavior a credible willingness to work to create a mutually better world. The "game" of ethics then becomes searching for strategies that overlap with others' strategies so that we are all better for intending to act on a basis of reciprocal trust. This is a difficult process because we have partial, simultaneous, shifting, and inconsistent views of the world. But despite the reality that we each "frame" ethics in personal terms, it is still possible to create sufficient common understanding to prosper together. Large ethics does not make it a prerequisite for moral behavior that everyone adheres to a universally agreed set of ethical principles; all that is necessary is sufficient overlap in commitment to searching for better alternatives.
Two universal physical principles shape the power-law statistics of real-world networks.
Lorimer, Tom; Gomez, Florian; Stoop, Ruedi
2015-01-01
The study of complex networks has pursued an understanding of macroscopic behaviour by focusing on power-laws in microscopic observables. Here, we uncover two universal fundamental physical principles that are at the basis of complex network generation. These principles together predict the generic emergence of deviations from ideal power laws, which were previously discussed away by reference to the thermodynamic limit. Our approach proposes a paradigm shift in the physics of complex networks, toward the use of power-law deviations to infer meso-scale structure from macroscopic observations.
Defending the beauty of the Invariance Principle
NASA Astrophysics Data System (ADS)
Barkana, Itzhak
2014-01-01
Customary stability analysis methods for nonlinear nonautonomous systems seem to require a strict condition of uniform continuity. Although extensions of LaSalle's Invariance Principle to nonautonomous systems that mitigate this condition have been available for a long time, they have remained surprisingly unknown or open to misinterpretations. The large scope of the Principle might have misled the prospective users and its application to Control problems has been received with amazing yet clear uneasiness. Counterexamples have been used in order to claim that the Invariance Principle cannot be applied to nonlinear nonautonomous systems. Because the original formulation of the Invariance Principle still imposes conditions that are not necessarily needed, this paper presents a new Invariance Principle that further mitigates previous conditions and thus further expands the scope of stability analysis. A brief comparative review of various alternatives to stability analysis of nonautonomous nonlinear systems and their implications is also presented in order to illustrate that thorough analysis of same examples may actually confirm the efficiency of the Invariance Principle approach when dealing with stability of nonautonomous nonlinear systems problems that may look difficult or even unsolvable otherwise.
14 CFR 119.57 - Obtaining deviation authority to perform an emergency operation.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Obtaining deviation authority to perform an emergency operation. 119.57 Section 119.57 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... supplies for the protection of life or property; and (2) The Administrator finds that a deviation...
49 CFR 213.332 - Combined track alinement and surface deviations.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 49 Transportation 4 2014-10-01 2014-10-01 false Combined track alinement and surface deviations... from uniformity (outward is positive, inward is negative). AL = allowable alinement limit as per § 213.327(c) (always positive) for the class of track. Sm = measured profile deviation from uniformity...
49 CFR 213.332 - Combined track alinement and surface deviations.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 49 Transportation 4 2013-10-01 2013-10-01 false Combined track alinement and surface deviations... from uniformity (outward is positive, inward is negative). AL = allowable alinement limit as per § 213.327(c) (always positive) for the class of track. Sm = measured profile deviation from uniformity...
49 CFR 213.65 - Combined track alinement and surface deviations.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 49 Transportation 4 2013-10-01 2013-10-01 false Combined track alinement and surface deviations... is positive, inward is negative). AL = allowable alinement limit as per § 213.55(b) (always positive) for the class of track. Sm = measured profile deviation from uniformity (down is positive, up...
49 CFR 213.65 - Combined track alinement and surface deviations.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 49 Transportation 4 2014-10-01 2014-10-01 false Combined track alinement and surface deviations... is positive, inward is negative). AL = allowable alinement limit as per § 213.55(b) (always positive) for the class of track. Sm = measured profile deviation from uniformity (down is positive, up...
Simple technique for the fabrication of a penta prism with high accuracy right angle deviation.
Chatterjee, Sanjib; Pavan Kumar, Y
2007-09-10
What we believe to be a new technique for the fabrication of a penta prism (PP) with high accuracy right angle deviation of the incident beam is presented. We derive simple formulas relating to the error in right angle deviation with the errors in 45 degrees (beta) and 90 degrees (delta) angles of a PP, and we determine error in right angle deviation from the angle ((error in right angle deviation)r) between the plane wavefronts reflected from the right angled surfaces (external Fresnel reflection on the entrance surface and internal Fresnel reflection on the exit surface) of a PP and the angular error (delta) between the same surfaces. The error in right angle deviation is determined from the measurement of (error in right angle deviation)r using an autocollimator and a Fizeau interferometer, and error in right angle deviation is corrected to a high order of accuracy during the final stage of polishing one of the slanted surfaces of the PP. A new technique to determine the magnitude and direction of the small values of (error in right angle deviation)r is proposed and verified. The result for a PP is presented.
An Upper Bound on Standard Deviation as a Function of Range
ERIC Educational Resources Information Center
Petocz, Peter
2005-01-01
This article disproves a conjecture that the ratio of the maximum standard deviation to the range of a set of data decreases as the number of data points increases. It also provides an alternative and more general approach for examining the standard deviation as a function of the range.
32 CFR 21.335 - Who can authorize deviations from the DoDGARs?
Code of Federal Regulations, 2011 CFR
2011-07-01
... Regulations § 21.335 Who can authorize deviations from the DoDGARs? (a) The Head of the DoD Component or his...) The Director of Defense Research and Engineering (DDR&E) or his or her designee must approve in... for class deviations from two parts of the DoDGARs, 32 CFR parts 32 and 33, in accordance with 32...
32 CFR 21.335 - Who can authorize deviations from the DoDGARs?
Code of Federal Regulations, 2010 CFR
2010-07-01
... Regulations § 21.335 Who can authorize deviations from the DoDGARs? (a) The Head of the DoD Component or his...) The Director of Defense Research and Engineering (DDR&E) or his or her designee must approve in... for class deviations from two parts of the DoDGARs, 32 CFR parts 32 and 33, in accordance with 32...
75 FR 67093 - Iceberg Water Deviating From Identity Standard; Temporary Permit for Market Testing
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-01
... HUMAN SERVICES Food and Drug Administration Iceberg Water Deviating From Identity Standard; Temporary.... standard of identity for bottled water. The purpose of the temporary permit is to allow the applicant to... facilitate market testing of foods deviating from the requirements of the standards of identity issued...
Quark condensate and deviations from string-like behaviour of meson spectra
NASA Astrophysics Data System (ADS)
Afonin, S. S.
2003-12-01
I analyze the hypothesis that deviations from the linear meson mass spectra appear due to the dynamical chiral symmetry breaking in QCD. It is shown that the linear mass spectrum for the light, non-strange vector and axial-vector mesons is then parametrized by the constant fπ, being successful phenomenologically. The toy model for deviations from linearity is proposed.
Sanfilippo, Paul G; Hammond, Christopher J; Staffieri, Sandra E; Kearns, Lisa S; Melissa Liew, S H; Barbour, Julie M; Hewitt, Alex W; Ge, Dongliang; Snieder, Harold; Mackinnon, Jane R; Brown, Shayne A; Lorenz, Birgit; Spector, Tim D; Martin, Nicholas G; Wilmer, Jeremy B; Mackey, David A
2012-10-01
Strabismus represents a complex oculomotor disorder characterized by the deviation of one or both eyes and poor vision. A more sophisticated understanding of the genetic liability of strabismus is required to guide searches for associated molecular variants. In this classical twin study of 1,462 twin pairs, we examined the relative influence of genes and environment in comitant strabismus, and the degree to which these influences can be explained by factors in common with refractive error. Participants were examined for the presence of latent ('phoria') and manifest ('tropia') strabismus using cover-uncover and alternate cover tests. Two phenotypes were distinguished: eso-deviation (esophoria and esotropia) and exo-deviation (exophoria and exotropia). Structural equation modeling was subsequently employed to partition the observed phenotypic variation in the twin data into specific variance components. The prevalence of eso-deviation and exo-deviation was 8.6% and 20.7%, respectively. For eso-deviation, the polychoric correlation was significantly greater in monozygotic (MZ) (r = 0.65) compared to dizygotic (DZ) twin pairs (r = 0.33), suggesting a genetic role (p = .003). There was no significant difference in polychoric correlation between MZ (r = 0.55) and DZ twin pairs (r = 0.53) for exo-deviation (p = .86), implying that genetic factors do not play a significant role in the etiology of exo-deviation. The heritability of an eso-deviation was 0.64 (95% CI 0.50-0.75). The additive genetic correlation for eso-deviation and refractive error was 0.13 and the bivariate heritability (i.e., shared variance) was less than 1%, suggesting negligible shared genetic effect. This study documents a substantial heritability of 64% for eso-deviation, yet no corresponding heritability for exo-deviation, suggesting that the genetic contribution to strabismus may be specific to eso-deviation. Future studies are now needed to identify the genes associated with eso-deviation and
Positronium, antihydrogen, light, and the equivalence principle
NASA Astrophysics Data System (ADS)
Karshenboim, Savely G.
2016-07-01
While discussing a certain generic difference in effects of gravity on particles and antiparticles, various neutral particles (i.e. the particles which are identical with their antiparticles) could be a perfect probe. One such neutral particles is the positronium atom, which has been available for precision experiments for a few decades. The other important neutral particle is the photon. Behavior of light in the presence of a gravitational field has been the key both to build and develop the theory of general relativity and to verify it experimentally. The very idea of antigravity for antimatter strongly contradicts both the principles of general relativity and its experimentally verified consequences. Consideration of existing experimental results on photons and positrons makes antigravity impossible and leads to a conclusion that the deviation of the ratio of acceleration of the free fall of particles and antiparticles cannot exceed the level of 1× {10}-5.
NASA Astrophysics Data System (ADS)
Scarascia, Luca; Lionello, Piero
2015-04-01
Future sea level rise (SL), which represents today one of the major threats that are caused by climate change, will not be uniform. Regional differences are crucial for 40% of the world population, which is located in the coastal zone. To explore the mechanisms linking regional SL to climate variables is very important in order to provide reliable future projections. This study focuses on two semi-enclosed basins, the Adriatic and Baltic Sea and investigates the deviation of their SL from the mean global value. In fact, past deviations of the SL of these two basins from the global value have been observed and can be attributed to large scale factors (such as teleconnections) and regional factors, such as the inverse barometric effect, the wind stress, the thermosteric and halosteric effects. The final goal of this work is to assess to which extent the Adriatic and Baltic SL will depart from the mean global value in the next decades and at the end of 21st century. This is achieved by analyzing deviations of the mean SL of the Baltic and Adriatic Sea from the global mean SL during the 20th century and investigating which factors can explain such deviations. A multivariate linear regression model is built and used to describe the link between three large scale climate variables which are used as predictors (mean sea level pressure, surface air temperature and precipitation), and the regional SL deviation (the predictand), computed as the difference between the regional and the global SL. At monthly scale this linear regression model provides a good reconstruction of the past variability in the cold season during which it explains 60%-70% of the variance. Summer reconstruction is substantially less successful and it represents presently the main limit of the model skill. This linear regression model, forced by predictors extracted from CMIP5 multi-model simulations, is used to provide projections of SL in the Adriatic and Baltic Sea. On the basis of the projections
Detection and compensation of basis deviation in satellite-to-ground quantum communications.
Zhang, Ming; Zhang, Liang; Wu, Jincai; Yang, Shiji; Wan, Xiong; He, Zhiping; Jia, Jianjun; Citrin, D S; Wang, Jianyu
2014-04-21
Basis deviation is the reference-frame deviation between a sender and receiver caused by satellite motion in satellite-to-ground quantum communications. It increases the quantum-bit error ratio of the system and must be compensated for to guarantee reliable quantum communications. We present a new scheme for compensating for basis deviation that employs a BB84 decoding module to detect basis deviation and half-wave plate to provide compensation. Based on this detection scheme, we design a basis-deviation compensation approach and test its feasibility in a voyage experiment. Unlike other polarization-correction schemes, this compensation scheme is simple, convenient, and can be easily implemented in satellite-to-ground quantum communications without increased burden to the satellite. PMID:24787870
Illusory shadow person causing paradoxical gaze deviations during temporal lobe seizures.
Zijlmans, M; van Eijsden, P; Ferrier, C H; Kho, K H; van Rijen, P C; Leijten, F S S
2009-06-01
Generally, activation of the frontal eye field during seizures can cause versive (forced) gaze deviation, while non-versive head deviation is hypothesised to result from ictal neglect after inactivation of the ipsilateral temporo-parietal area. Almost all non-versive head deviations occurring during temporal lobe seizures are directed to the side of seizure onset, so in derogatory cases it is worth while explaining the paradoxical event. We present a patient with a paradoxical direction of gaze deviation during temporal lobe seizures with an unexpected explanation. Electrocortical stimulation of the temporo-parieto-occipital junction elicited an irrepressible urge to look towards an illusory shadow person besides the patient. Paradoxical non-versive gaze deviations in temporal lobe seizures may be due to illusory experiences masked by postictal amnesia. PMID:19448096
Illusory shadow person causing paradoxical gaze deviations during temporal lobe seizures.
Zijlmans, M; van Eijsden, P; Ferrier, C H; Kho, K H; van Rijen, P C; Leijten, F S S
2009-06-01
Generally, activation of the frontal eye field during seizures can cause versive (forced) gaze deviation, while non-versive head deviation is hypothesised to result from ictal neglect after inactivation of the ipsilateral temporo-parietal area. Almost all non-versive head deviations occurring during temporal lobe seizures are directed to the side of seizure onset, so in derogatory cases it is worth while explaining the paradoxical event. We present a patient with a paradoxical direction of gaze deviation during temporal lobe seizures with an unexpected explanation. Electrocortical stimulation of the temporo-parieto-occipital junction elicited an irrepressible urge to look towards an illusory shadow person besides the patient. Paradoxical non-versive gaze deviations in temporal lobe seizures may be due to illusory experiences masked by postictal amnesia.
Detection and compensation of basis deviation in satellite-to-ground quantum communications.
Zhang, Ming; Zhang, Liang; Wu, Jincai; Yang, Shiji; Wan, Xiong; He, Zhiping; Jia, Jianjun; Citrin, D S; Wang, Jianyu
2014-04-21
Basis deviation is the reference-frame deviation between a sender and receiver caused by satellite motion in satellite-to-ground quantum communications. It increases the quantum-bit error ratio of the system and must be compensated for to guarantee reliable quantum communications. We present a new scheme for compensating for basis deviation that employs a BB84 decoding module to detect basis deviation and half-wave plate to provide compensation. Based on this detection scheme, we design a basis-deviation compensation approach and test its feasibility in a voyage experiment. Unlike other polarization-correction schemes, this compensation scheme is simple, convenient, and can be easily implemented in satellite-to-ground quantum communications without increased burden to the satellite.
The GS (genetic selection) Principle.
Abel, David L
2009-01-01
The GS (Genetic Selection) Principle states that biological selection must occur at the nucleotide-sequencing molecular-genetic level of 3'5' phosphodiester bond formation. After-the-fact differential survival and reproduction of already-living phenotypic organisms (ordinary natural selection) does not explain polynucleotide prescription and coding. All life depends upon literal genetic algorithms. Even epigenetic and "genomic" factors such as regulation by DNA methylation, histone proteins and microRNAs are ultimately instructed by prior linear digital programming. Biological control requires selection of particular configurable switch-settings to achieve potential function. This occurs largely at the level of nucleotide selection, prior to the realization of any integrated biofunction. Each selection of a nucleotide corresponds to the setting of two formal binary logic gates. The setting of these switches only later determines folding and binding function through minimum-free-energy sinks. These sinks are determined by the primary structure of both the protein itself and the independently prescribed sequencing of chaperones. The GS Principle distinguishes selection of existing function (natural selection) from selection for potential function (formal selection at decision nodes, logic gates and configurable switch-settings).
The Impact of Advanced Technologies on Treatment Deviations in Radiation Treatment Delivery
Marks, Lawrence B. Light, Kim L.; Hubbs, Jessica L.; Georgas, Debra L.; Jones, Ellen L.; Wright, Melanie C.; Willett, Christopher G.; Yin Fangfang
2007-12-01
Purpose: To assess the impact of new technologies on deviation rates in radiation therapy (RT). Methods and Materials: Treatment delivery deviations in RT were prospectively monitored during a time of technology upgrade. In January 2003, our department had three accelerators, none with 'modern' technologies (e.g., without multileaf collimators [MLC]). In 2003 to 2004, we upgraded to five new accelerators, four with MLC, and associated advanced capabilities. The deviation rates among patients treated on 'high-technology' versus 'low-technology' machines (defined as those with vs. without MLC) were compared over time using the two-tailed Fisher's exact test. Results: In 2003, there was no significant difference between the deviation rate in the 'high-technology' versus 'low-technology' groups (0.16% vs. 0.11%, p = 0.45). In 2005 to 2006, the deviation rate for the 'high-technology' groups was lower than the 'low-technology' (0.083% vs. 0.21%, p = 0.009). This difference was caused by a decline in deviations on the 'high-technology' machines over time (p = 0.053), as well as an unexpected trend toward an increase in deviations over time on the 'low-technology' machines (p = 0.15). Conclusions: Advances in RT delivery systems appear to reduce the rate of treatment deviations. Deviation rates on 'high-technology' machines with MLC decline over time, suggesting a learning curve after the introduction of new technologies. Associated with the adoption of 'high-technology' was an unexpected increase in the deviation rate with 'low-technology' approaches, which may reflect an over-reliance on tools inherent to 'high-technology' machines. With the introduction of new technologies, continued diligence is needed to ensure that staff remain proficient with 'low-technology' approaches.
Providing Runtime Clock Synchronization With Minimal Node-to-Node Time Deviation on XT4s and XT5s
Jones, Terry R; Koenig, Gregory A
2011-01-01
We present a new high precision clock synchronization algorithm designed for large XT4 and XT5 leadership-class machines. The algorithm, which is designed to support OS noise reduction through co-scheduling, is suitable for usage cases requiring low overhead and minimal time deviation between nodes. Unlike most high-precision algorithms which reach their precision in a post-mortem analysis after the application has completed, the new ORNL developed algorithm rapidly provides precise results during runtime. Previous to our work, the leading high-precision clock synchronization algorithms that made results available during runtime relied on probabilistic schemes that are not guaranteed to result in an answer.
Common Principles and Multiculturalism
Zahedi, Farzaneh; Larijani, Bagher
2009-01-01
Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea. PMID:23908720
Common principles and multiculturalism.
Zahedi, Farzaneh; Larijani, Bagher
2009-01-01
Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea.
Common principles and multiculturalism.
Zahedi, Farzaneh; Larijani, Bagher
2009-01-01
Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea. PMID:23908720
Principles of Natural Photosynthesis.
Krewald, Vera; Retegan, Marius; Pantazis, Dimitrios A
2016-01-01
Nature relies on a unique and intricate biochemical setup to achieve sunlight-driven water splitting. Combined experimental and computational efforts have produced significant insights into the structural and functional principles governing the operation of the water-oxidizing enzyme Photosystem II in general, and of the oxygen-evolving manganese-calcium cluster at its active site in particular. Here we review the most important aspects of biological water oxidation, emphasizing current knowledge on the organization of the enzyme, the geometric and electronic structure of the catalyst, and the role of calcium and chloride cofactors. The combination of recent experimental work on the identification of possible substrate sites with computational modeling have considerably limited the possible mechanistic pathways for the critical O-O bond formation step. Taken together, the key features and principles of natural photosynthesis may serve as inspiration for the design, development, and implementation of artificial systems. PMID:26099285