Science.gov

Sample records for lateral perangkat elektronik

  1. 76 FR 24883 - DNB Exports LLC, and AFI Elektromekanikanik Ve Elektronik San. Tic. Ltd. Sti. v. Barsan Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION DNB Exports LLC, and AFI Elektromekanikanik Ve Elektronik San. Tic. Ltd. Sti. v. Barsan Global... Commission (``Commission'') by DNB Exports LLC (``DNB''), and AFI Elektromekanikanik Ve Elektronik San....

  2. New BEV/E+E Elektronik Low-Frost-Point/High-Pressure Generator

    NASA Astrophysics Data System (ADS)

    Mitter, H.

    2015-08-01

    Currently, the humidity standard at BEV/E+E is limited in the lower frost-point range to at pressures up to 1 MPa and to at ambient pressure. The system is also mainly designed for use with pure nitrogen as the carrier gas. In recent years, there has been a demand for humidity measurements in non-air gases (NAG) in contrast to "air gases" such as nitrogen, synthetic air, and -free standard air, even at pressures up to 10 MPa and in the frost-point range down to . NAGs can be gases such as , , and gas mixtures such as natural gas. To fulfill the requirements for humidity standards—especially in the high-pressure range—and to give the opportunity to determine thermodynamic properties such as enhancement factors in different carrier gases, a new "low-frost-point/high-pressure humidity generator" has been designed and verified at BEV/E+E Elektronik. The new humidity generator is designed as a single-pass generator with a maximum standard flow of and can be operated in the two-pressure mode as well as in the single-pressure mode at pressures up to 10 MPa. The design of the saturator focussed on reliability at high pressures and on achieving sufficient saturation efficiency at temperatures down to at least . First results of verification are presented in the range of saturator temperatures from to and at pressures up to 10 MPa. High-pressure data are presented for nitrogen and methane as carrier gases.

  3. Lateral genomics.

    PubMed

    Doolittle, W F

    1999-12-01

    More than 20 complete prokaryotic genome sequences are now publicly available, each by itself an unparalleled resource for understanding organismal biology. Collectively, these data are even more powerful: they could force a dramatic reworking of the framework in which we understand biological evolution. It is possible that a single universal phylogenetic tree is not the best way to depict relationships between all living and extinct species. Instead a web- or net-like pattern, reflecting the importance of horizontal or lateral gene transfer between lineages of organisms, might provide a more appropriate visual metaphor. Here, I ask whether this way of thinking is really justified, and explore its implications.

  4. Lateral flow strip assay

    DOEpatents

    Miles, Robin R.; Benett, William J.; Coleman, Matthew A.; Pearson, Francesca S.; Nasarabadi, Shanavaz L.

    2011-03-08

    A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.

  5. Lateral canthal surgery.

    PubMed

    Chong, Kelvin Kam-Lung; Goldberg, Robert A

    2010-08-01

    The lateral canthus is a delicate and complicated three-dimensional structure with function relevant to the health of the ocular surface. Dysfunction of the lateral canthus, due to aging changes or iatrogenic trauma, results in ocular morbidity ranging from chronic irritation to tearing to recalcitrant keratopathy. From an aesthetic standpoint, symmetric, normally positioned lateral canthi are cornerstones of youthful periorbital appearance, disruption of which leads to cosmetically significant deformity or asymmetry. Reconstruction of the lateral canthus is important in the rehabilitation of the aging eyelid and an unfortunate necessity after failed lateral canthal surgery. The common methods for improving or maintaining position, tone, and shape of the lower eyelid and lateral canthus use tightening or shortening the lower eyelid horizontally, keeping the canthal angle in an appropriate vertical level, and hugging the ocular surface. Many techniques have been described for the reconstruction of the lateral canthus in functional conditions or for aesthetic purposes. These methods have met with varying success. In this article, we begin with a discussion of the anatomy and physiology of the lateral canthus, followed by clinical examples of lateral canthal abnormalities and underlying pathophysiologies. A review of surgical options for the lateral canthus is presented with concluding remarks on postoperative complications. PMID:20524167

  6. Reading Disability and Laterality.

    ERIC Educational Resources Information Center

    Sparrow, Sara S.

    The purpose of this study was to determine how retarded readers differed from normal readers in the various ways laterality is manifested. An additional purpose was to investigate the development of laterality as seen across several age levels. Subjects were 80 white male 9-, 10-, 11-, and 12-year-olds from regular classrooms in suburban…

  7. Lateral subtalar dislocation.

    PubMed

    Sharda, Praveen; DuFosse, Julian

    2008-07-01

    Subtalar dislocations are rare in routine orthopedic practice. While many of these dislocations are a result of high-energy injuries such as fall from a height or traffic accidents, it is not uncommon for patients to present after slipping down a few stairs. Two types of dislocation have been described, medial and lateral. The type of dislocation is described according to the position of the foot. In lateral subtalar dislocation the head of talus is found medially and the calcaneus is dislocated laterally. The navicular may lie dorsolateral to the talus. The reverse is true of lateral dislocation. Medial dislocation has been referred to as "basketball foot" due to its preponderance in basketball players.4 The deciding factor is the inverted or everted position of the foot when the force is dissipated through the weak talonavicular and talocalcaneal ligaments. This article presents a case of an adult with lateral subtalar dislocation following a fall.

  8. Lateral superlattice solar cells

    SciTech Connect

    Mascarenhas, A.; Zhang, Y.; Millunchick, J.M.; Twesten, R.D.; Jones, E.D.

    1997-10-01

    A novel structure which comprises of a lateral superlattice as the active layer of a solar cell is proposed. If the alternating regions A and B of a lateral superlattice ABABAB... are chosen to have a Type-II band offset, it is shown that the performance of the active absorbing region of the solar cell is optimized. In essence, the Type-II lateral superlattice region can satisfy the material requirements for an ideal solar cells active absorbing region, i.e. simultaneously having a very high transition probability for photogeneration and a very long minority carrier recombination lifetime.

  9. Amyotrophic Lateral Sclerosis

    MedlinePlus

    Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your ... people with ALS die from respiratory failure. The disease usually strikes between age 40 and 60. More ...

  10. Lateral orientation (image)

    MedlinePlus

    ... chest, and the ears are lateral to the head. A medial orientation is a position toward the midline of the body. An example of medial orientation is the eyes, which are medial to the ears on the head.

  11. Preventing errors in laterality.

    PubMed

    Landau, Elliot; Hirschorn, David; Koutras, Iakovos; Malek, Alexander; Demissie, Seleshie

    2015-04-01

    An error in laterality is the reporting of a finding that is present on the right side as on the left or vice versa. While different medical and surgical specialties have implemented protocols to help prevent such errors, very few studies have been published that describe these errors in radiology reports and ways to prevent them. We devised a system that allows the radiologist to view reports in a separate window, displayed in a simple font and with all terms of laterality highlighted in separate colors. This allows the radiologist to correlate all detected laterality terms of the report with the images open in PACS and correct them before the report is finalized. The system is monitored every time an error in laterality was detected. The system detected 32 errors in laterality over a 7-month period (rate of 0.0007 %), with CT containing the highest error detection rate of all modalities. Significantly, more errors were detected in male patients compared with female patients. In conclusion, our study demonstrated that with our system, laterality errors can be detected and corrected prior to finalizing reports.

  12. Laterally bendable belt conveyor

    SciTech Connect

    Peterson, W.J.

    1982-09-24

    An endless, laterally flexible and bendable belt conveyor particularly adapted for coal mining applications in facilitating the transport of the extracted coal up- or downslope and around corners in a continuous manner is disclosed. The conveying means includes a flat rubber belt reinforced along the middle portion thereof along which the major portion of the belt tension is directed so as to cause rotation of the tubular shaped belt when trammed around lateral turns thus preventing excessive belt bulging distortion between adjacent belt supports which would inhibit belt transport. Pretension induced into the fabric reinforced flat rubber belt by conventional belt take-up means supports the load conveyed when the belt conveyor is making lateral turns. The carrying and return portions of the belt are supported and formed into a tubular shape by a plurality of shapers positioned along its length. Each shaper is supported from above by a monorail and includes clusters of idler rollers which support the belt. Additional cluster rollers in each shaper permit the belt supporting roller clusters to rotate in response to the belt's operating tension imposed upon the cluster rollers by induced lateral belt friction forces. The freely rotating roller clusters thus permit the belt to twist on lateral curves without damage to itself while precluding escape of the conveyed material by effectively enclosing it in the tube-shaped, inner belt transport length.

  13. Laterally closed lattice homomorphisms

    NASA Astrophysics Data System (ADS)

    Toumi, Mohamed Ali; Toumi, Nedra

    2006-12-01

    Let A and B be two Archimedean vector lattices and let be a lattice homomorphism. We call that T is laterally closed if T(D) is a maximal orthogonal system in the band generated by T(A) in B, for each maximal orthogonal system D of A. In this paper we prove that any laterally closed lattice homomorphism T of an Archimedean vector lattice A with universal completion Au into a universally complete vector lattice B can be extended to a lattice homomorphism of Au into B, which is an improvement of a result of M. Duhoux and M. Meyer [M. Duhoux and M. Meyer, Extended orthomorphisms and lateral completion of Archimedean Riesz spaces, Ann. Soc. Sci. Bruxelles 98 (1984) 3-18], who established it for the order continuous lattice homomorphism case. Moreover, if in addition Au and B are with point separating order duals (Au)' and B' respectively, then the laterally closedness property becomes a necessary and sufficient condition for any lattice homomorphism to have a similar extension to the whole Au. As an application, we give a new representation theorem for laterally closed d-algebras from which we infer the existence of d-algebra multiplications on the universal completions of d-algebras.

  14. Laterally bendable belt conveyor

    DOEpatents

    Peterson, William J.

    1985-01-01

    An endless, laterally flexible and bendable belt conveyor particularly adapted for coal mining applications in facilitating the transport of the extracted coal up- or downslope and around corners in a continuous manner is disclosed. The conveying means includes a flat rubber belt reinforced along the middle portion thereof along which the major portion of the belt tension is directed so as to cause rotation of the tubular shaped belt when trammed around lateral turns thus preventing excessive belt bulging distortion between adjacent belt supports which would inhibit belt transport. Pretension induced into the fabric reinforced flat rubber belt by conventional belt take-up means supports the load conveyed when the belt conveyor is making lateral turns. The carrying and return portions of the belt are supported and formed into a tubular shape by a plurality of shapers positioned along its length. Each shaper is supported from above by a monorail and includes clusters of idler rollers which support the belt. Additional cluster rollers in each shaper permit the belt supporting roller clusters to rotate in response to the belt's operating tension imposed upon the cluster rollers by induced lateral belt friction forces. The freely rotating roller clusters thus permit the belt to twist on lateral curves without damage to itself while precluding escape of the conveyed material by effectively enclosing it in the tube-shaped, inner belt transport length.

  15. Unusual atypical language lateralization.

    PubMed

    Khan, Muhammad T; Oghlakian, Roger; Koubeissi, Mohamad Z

    2016-01-01

    Determining the language-dominant hemisphere is essential for planning epilepsy surgery. A 60-year-old right-handed woman with epilepsy since age 16 failed a partial right anterior lobectomy at age 21. Later, a brain MRI found extensive right-sided cortical dysplasia and periventricular heterotopia. Subsequently, prolonged video-EEG monitoring localized her seizures to the right temporoparietal region. Functional MRI was inconclusive in lateralizing her language, prompting a Wada test, which strongly lateralized language to the right. This unique case of atypical language representation in a right-handed individual with an extensive right-hemispheric congenital malformation and seizure focus illustrates the important thorough presurgical language assessment. PMID:27668182

  16. Lateral Thinking of Prospective Teachers

    ERIC Educational Resources Information Center

    Lawrence, A. S. Arul; Xavier, S. Amaladoss

    2013-01-01

    Edward de Bono who invented the term "lateral thinking" in 1967 is the pioneer of lateral thinking. Lateral thinking is concerned with the generation of new ideas. Liberation from old ideas and the stimulation of new ones are twin aspects of lateral thinking. Lateral thinking is a creative skills from which all people can benefit…

  17. Laterally bendable belt conveyor

    SciTech Connect

    Peterson, W.J.

    1985-07-02

    An endless, laterally flexible and bendable belt conveyor particularly adapted for coal mining applications in facilitating the transport of the extracted coal up- or downslope and around corners in a continuous manner is disclosed. The conveying means includes a flat rubber belt reinforced along the middle portion thereof along which the major portion of the belt tension is directed so as to cause rotation of the tubular shaped belt when trammed around lateral turns thus preventing excessive belt bulging distortion between adjacent belt supports which would inhibit belt transport. Pretension induced into the fabric reinforced flat rubber belt by conventional belt take-up means supports the load conveyed when the belt conveyor is making laterial turns. The carrying and return portions of the belt are supported and formed into a tubular shape by a plurality of shapers positioned along its length. Each shaper is supported from above by a monorail and includes clusters of idler rolles which support the belt. Additional cluster rollers in each shaper permit the belt supporting roller clusters to rotate in response to the belt's operating tension imposed upon the cluster rollers by induced lateral belt friction forces. The freely rotating roller clusters thus permit the belt to twist on lateral curves without damage to itself while precluding escape of the conveyed material by effectively enclosing it in the tube-shaped, inner belt transport length.

  18. Humor in Later Life.

    ERIC Educational Resources Information Center

    Frazier, Billie H.

    This document contains a brief bibliography of peer-reviewed literature, with abstracts, on humor in later life. It is one of 12 bibliographies on aging prepared by the National Agricultural Library for its "Pathfinders" series of publications. Topics covered by the other 11 bibliographies include aging parents, adult children, dementia and…

  19. Holographic lateral shear interferometer.

    PubMed

    Malacara, D; Mallick, S

    1976-11-01

    A new type of lateral shear holographic interferometer is described. It can be used to test lenses as well as spherical and aspherical surfaces. A null pattern with straight fringes can be obtained for an aspherical surface, provided one has a prototype that can be used for making the hologram.

  20. Lateral flow assays.

    PubMed

    Koczula, Katarzyna M; Gallotta, Andrea

    2016-06-30

    Lateral flow assays (LFAs) are the technology behind low-cost, simple, rapid and portable detection devices popular in biomedicine, agriculture, food and environmental sciences. This review presents an overview of the principle of the method and the critical components of the assay, focusing on lateral flow immunoassays. This type of assay has recently attracted considerable interest because of its potential to provide instantaneous diagnosis directly to patients. The range and interpretation of results and parameters used for evaluation of the assay will also be discussed. The main advantages and disadvantages of LFAs will be summarized and relevant future improvements to testing devices and strategies will be proposed. Finally, the major recent advances and future diagnostic applications in the LFA field will be explored. PMID:27365041

  1. Lateral flow assays

    PubMed Central

    Koczula, Katarzyna M.

    2016-01-01

    Lateral flow assays (LFAs) are the technology behind low-cost, simple, rapid and portable detection devices popular in biomedicine, agriculture, food and environmental sciences. This review presents an overview of the principle of the method and the critical components of the assay, focusing on lateral flow immunoassays. This type of assay has recently attracted considerable interest because of its potential to provide instantaneous diagnosis directly to patients. The range and interpretation of results and parameters used for evaluation of the assay will also be discussed. The main advantages and disadvantages of LFAs will be summarized and relevant future improvements to testing devices and strategies will be proposed. Finally, the major recent advances and future diagnostic applications in the LFA field will be explored. PMID:27365041

  2. Lateral Attitude Change.

    PubMed

    Glaser, Tina; Dickel, Nina; Liersch, Benjamin; Rees, Jonas; Süssenbach, Philipp; Bohner, Gerd

    2015-08-01

    The authors propose a framework distinguishing two types of lateral attitude change (LAC): (a) generalization effects, where attitude change toward a focal object transfers to related objects, and (b) displacement effects, where only related attitudes change but the focal attitude does not change. They bring together examples of LAC from various domains of research, outline the conditions and underlying processes of each type of LAC, and develop a theoretical framework that enables researchers to study LAC more systematically in the future. Compared with established theories of attitude change, the LAC framework focuses on lateral instead of focal attitude change and encompasses both generalization and displacement. Novel predictions and designs for studying LAC are presented.

  3. Conjugal amyotrophic lateral sclerosis

    PubMed Central

    Dewitt, John D.; Kwon, Julia; Burton, Rebecca

    2012-01-01

    Amyotrophic lateral sclerosis (ALS) is a disease characterized by progressive degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. The incidence of sporadic ALS is 1.5 to 2.7 in 100,000, and the prevalence is 5.2 to 6.0 in 100,000. Conjugal ALS is even rarer than sporadic ALS. We report a case of conjugal ALS encountered in our outpatient neurology clinic. PMID:22275781

  4. Hemispheric lateralization in reasoning.

    PubMed

    Turner, Benjamin O; Marinsek, Nicole; Ryhal, Emily; Miller, Michael B

    2015-11-01

    A growing body of evidence suggests that reasoning in humans relies on a number of related processes whose neural loci are largely lateralized to one hemisphere or the other. A recent review of this evidence concluded that the patterns of lateralization observed are organized according to two complementary tendencies. The left hemisphere attempts to reduce uncertainty by drawing inferences or creating explanations, even at the cost of ignoring conflicting evidence or generating implausible explanations. Conversely, the right hemisphere aims to reduce conflict by rejecting or refining explanations that are no longer tenable in the face of new evidence. In healthy adults, the hemispheres work together to achieve a balance between certainty and consistency, and a wealth of neuropsychological research supports the notion that upsetting this balance results in various failures in reasoning, including delusions. However, support for this model from the neuroimaging literature is mixed. Here, we examine the evidence for this framework from multiple research domains, including an activation likelihood estimation analysis of functional magnetic resonance imaging studies of reasoning. Our results suggest a need to either revise this model as it applies to healthy adults or to develop better tools for assessing lateralization in these individuals. PMID:26426534

  5. Lateral Lumbar Interbody Fusion.

    PubMed

    Pawar, Abhijit; Hughes, Alexander; Girardi, Federico; Sama, Andrew; Lebl, Darren; Cammisa, Frank

    2015-12-01

    The lateral lumbar interbody fusion (LLIF) is a relatively new technique that allows the surgeon to access the intervertebral space from a direct lateral approach either anterior to or through the psoas muscle. This approach provides an alternative to anterior lumbar interbody fusion with instrumentation, posterior lumbar interbody fusion, and transforaminal lumbar interbody fusion for anterior column support. LLIF is minimally invasive, safe, better structural support from the apophyseal ring, potential for coronal plane deformity correction, and indirect decompression, which have has made this technique popular. LLIF is currently being utilized for a variety of pathologies including but not limited to adult de novo lumbar scoliosis, central and foraminal stenosis, spondylolisthesis, and adjacent segment degeneration. Although early clinical outcomes have been good, the potential for significant neurological and vascular vertebral endplate complications exists. Nevertheless, LLIF is a promising technique with the potential to more effectively treat complex adult de novo scoliosis and achieve predictable fusion while avoiding the complications of traditional anterior surgery and posterior interbody techniques. PMID:26713134

  6. Lateral Lumbar Interbody Fusion

    PubMed Central

    Hughes, Alexander; Girardi, Federico; Sama, Andrew; Lebl, Darren; Cammisa, Frank

    2015-01-01

    The lateral lumbar interbody fusion (LLIF) is a relatively new technique that allows the surgeon to access the intervertebral space from a direct lateral approach either anterior to or through the psoas muscle. This approach provides an alternative to anterior lumbar interbody fusion with instrumentation, posterior lumbar interbody fusion, and transforaminal lumbar interbody fusion for anterior column support. LLIF is minimally invasive, safe, better structural support from the apophyseal ring, potential for coronal plane deformity correction, and indirect decompression, which have has made this technique popular. LLIF is currently being utilized for a variety of pathologies including but not limited to adult de novo lumbar scoliosis, central and foraminal stenosis, spondylolisthesis, and adjacent segment degeneration. Although early clinical outcomes have been good, the potential for significant neurological and vascular vertebral endplate complications exists. Nevertheless, LLIF is a promising technique with the potential to more effectively treat complex adult de novo scoliosis and achieve predictable fusion while avoiding the complications of traditional anterior surgery and posterior interbody techniques. PMID:26713134

  7. 8. UPPER INSIDE CHORD, VERTICAL, LATERAL STRUT, UPPER LATERAL & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. UPPER INSIDE CHORD, VERTICAL, LATERAL STRUT, UPPER LATERAL & GUSSET PLATE, ONE DIAGONAL BRACE - Enterprise Parker Truss Bridge, Spanning Smoky Hill River on K-43 Highway, Enterprise, Dickinson County, KS

  8. 7. UPPER INSIDE CHORD, VERTICAL, LATERAL STRUT, UPPER LATERAL & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. UPPER INSIDE CHORD, VERTICAL, LATERAL STRUT, UPPER LATERAL & GUSSET PLATE, TWO DIAGONAL BRACES - Enterprise Parker Truss Bridge, Spanning Smoky Hill River on K-43 Highway, Enterprise, Dickinson County, KS

  9. Laterality and language experience.

    PubMed

    Hull, Rachel; Vaid, Jyotsna

    2006-09-01

    A meta-analysis was conducted on studies that examined hemispheric functional asymmetry for language in brain-intact monolingual and bilingual adults. Data from 23 laterality studies that directly compared bilingual and monolingual speakers on the same language were analysed (n = 1234). Variables examined were language experience (monolingual, bilingual), experimental paradigm (dichotic listening, visual hemifield presentation, and dual task) and, among bilinguals, the influence of second language proficiency (proficient vs nonproficient) and onset of bilingualism (early, or before age 6; and late, or after age 6). Overall, monolinguals and late bilinguals showed reliable left hemisphere dominance, while early bilinguals showed reliable bilateral hemispheric involvement. Within bilinguals, there was no reliable effect of language proficiency when age of L2 acquisition was controlled. The findings indicate that early learning of one vs. two languages predicts divergent patterns of cerebral language lateralisation in adulthood. PMID:16882556

  10. Lateral Flow Immunoassay.

    PubMed

    Ching, Kathryn H

    2015-01-01

    Lateral flow immunoassays (LFIAs) are a staple in the field of rapid diagnostics. These small handheld devices require no specialized training or equipment to operate, and generate a result within minutes of sample application. They are an ideal format for many types of home test kits, for emergency responders and for food manufacturers and producers looking for a quick evaluation of a given sample. LFIAs rely on high quality monoclonal antibodies that recognize the analyte of interest. As monoclonal antibody technology becomes more accessible to smaller laboratories, there has been increased interest in developing LFIA prototypes for potential commercial manufacture. In this chapter, the basics of designing and building an LFIA prototype are described. PMID:26160571

  11. Lateral conduction infrared photodetector

    DOEpatents

    Kim, Jin K.; Carroll, Malcolm S.

    2011-09-20

    A photodetector for detecting infrared light in a wavelength range of 3-25 .mu.m is disclosed. The photodetector has a mesa structure formed from semiconductor layers which include a type-II superlattice formed of alternating layers of InAs and In.sub.xGa.sub.1-xSb with 0.ltoreq.x.ltoreq.0.5. Impurity doped regions are formed on sidewalls of the mesa structure to provide for a lateral conduction of photo-generated carriers which can provide an increased carrier mobility and a reduced surface recombination. An optional bias electrode can be used in the photodetector to control and vary a cut-off wavelength or a depletion width therein. The photodetector can be formed as a single-color or multi-color device, and can also be used to form a focal plane array which is compatible with conventional read-out integrated circuits.

  12. Laterality and language experience.

    PubMed

    Hull, Rachel; Vaid, Jyotsna

    2006-09-01

    A meta-analysis was conducted on studies that examined hemispheric functional asymmetry for language in brain-intact monolingual and bilingual adults. Data from 23 laterality studies that directly compared bilingual and monolingual speakers on the same language were analysed (n = 1234). Variables examined were language experience (monolingual, bilingual), experimental paradigm (dichotic listening, visual hemifield presentation, and dual task) and, among bilinguals, the influence of second language proficiency (proficient vs nonproficient) and onset of bilingualism (early, or before age 6; and late, or after age 6). Overall, monolinguals and late bilinguals showed reliable left hemisphere dominance, while early bilinguals showed reliable bilateral hemispheric involvement. Within bilinguals, there was no reliable effect of language proficiency when age of L2 acquisition was controlled. The findings indicate that early learning of one vs. two languages predicts divergent patterns of cerebral language lateralisation in adulthood.

  13. Lateral Abdominal Wall Reconstruction

    PubMed Central

    Baumann, Donald P.; Butler, Charles E.

    2012-01-01

    Lateral abdominal wall (LAW) defects can manifest as a flank hernias, myofascial laxity/bulges, or full-thickness defects. These defects are quite different from those in the anterior abdominal wall defects and the complexity and limited surgical options make repairing the LAW a challenge for the reconstructive surgeon. LAW reconstruction requires an understanding of the anatomy, physiologic forces, and the impact of deinnervation injury to design and perform successful reconstructions of hernia, bulge, and full-thickness defects. Reconstructive strategies must be tailored to address the inguinal ligament, retroperitoneum, chest wall, and diaphragm. Operative technique must focus on stabilization of the LAW to nonyielding points of fixation at the anatomic borders of the LAW far beyond the musculofascial borders of the defect itself. Thus, hernias, bulges, and full-thickness defects are approached in a similar fashion. Mesh reinforcement is uniformly required in lateral abdominal wall reconstruction. Inlay mesh placement with overlying myofascial coverage is preferred as a first-line option as is the case in anterior abdominal wall reconstruction. However, interposition bridging repairs are often performed as the surrounding myofascial tissue precludes a dual layered closure. The decision to place bioprosthetic or prosthetic mesh depends on surgeon preference, patient comorbidities, and clinical factors of the repair. Regardless of mesh type, the overlying soft tissue must provide stable cutaneous coverage and obliteration of dead space. In cases where the fasciocutaneous flaps surrounding the defect are inadequate for closure, regional pedicled flaps or free flaps are recruited to achieve stable soft tissue coverage. PMID:23372458

  14. Lateral compartment cartilage changes and lateral elbow pain.

    PubMed

    Rajeev, Aysha; Pooley, Joseph

    2009-02-01

    The aim of our study is to document the arthroscopic findings in resistant lateral elbow pain. We have reviewed the findings in a consecutive series of 117 elbow arthroscopies performed on patients with lateral elbow pain resistant to conservative treatment. We found established degenerative changes involving articular cartilage in 68 patients (59%). In 60 of these 68 patients (88%) the degenerative changes were confined to the lateral compartment and contrasted with a normal appearance of the articular cartilage of the medial compartment. Primary lateral compartment arthritis is more common than previously thought, it mostly affects a young population and could easily be misdiagnosed as lateral epicondylitis.

  15. Reflexive Planning for Later Life

    ERIC Educational Resources Information Center

    Denton, Margaret A.; Kemp, Candace L.; French, Susan; Gafni, Amiram; Joshi, Anju; Rosenthal, Carolyn J.; Davies, Sharon

    2004-01-01

    Informed by Giddens' (1991) concept of "reflexive life" planning and the notion of later life as a time of increasing social and financial risk, this research explores the idea of "reflexive planning for later life". We utilize a conceptual model that incorporates three types of planning for later life: public protection, self-insurance, and…

  16. Diamond heteroepitaxial lateral overgrowth

    NASA Astrophysics Data System (ADS)

    Tang, Yung-Hsiu

    This dissertation describes improvements in the growth of single crystal diamond by microwave plasma-assisted chemical vapor deposition (CVD). Heteroepitaxial (001) diamond was grown on 1 cm. 2 a-plane sapphiresubstrates using an epitaxial (001) Ir thin-film as a buffer layer. Low-energy ion bombardment of the Ir layer, a process known as bias-enhanced nucleation, is a key step in achieving a high density of diamond nuclei. Bias conditions were optimized to form uniformly-high nucleation densities across the substrates, which led to well-coalesced diamond thin films after short growth times. Epitaxial lateral overgrowth (ELO) was used as a means of decreasing diamond internal stress by impeding the propagation of threading dislocations into the growing material. Its use in diamond growth requires adaptation to the aggressive chemical and thermal environment of the hydrogen plasma in a CVD reactor. Three ELO variants were developed. The most successful utilized a gold (Au) mask prepared by vacuum evaporation onto the surface of a thin heteroepitaxial diamond layer. The Au mask pattern, a series of parallel stripes on the micrometer scale, was produced by standard lift-off photolithography. When diamond overgrows the mask, dislocations are largely confined to the substrate. Differing degrees of confinement were studied by varying the stripe geometry and orientation. Significant improvement in diamond quality was found in the overgrown regions, as evidenced by reduction of the Raman scattering linewidth. The Au layer was found to remain intact during diamond overgrowth and did not chemically bond with the diamond surface. Besides impeding the propagation of threading dislocations, it was discovered that the thermally-induced stress in the CVD diamond was significantly reduced as a result of the ductile Au layer. Cracking and delamination of the diamond from the substrate was mostly eliminated. When diamond was grown to thicknesses above 0.1 mm it was found that

  17. MediMax Elektronik-Marktkette

    NASA Astrophysics Data System (ADS)

    Die Elektronikkette MediMax setzt auf Server Based Computing mit Windows Server 2003® und Thin Clients. Mit über 100 Filialen ist MediMax die erfolgreiche Fachmarktlinie der ElectronicPartner-Verbundgruppe in Deutschland. Die Zugehörigkeit zum Mutterverbund garantiert den Franchisenehmern der Elektronikkette eine schnelle Warenversorgung und günstige Einkaufskonditionen. Über 50.000 Artikel zahlreicher namhafter Markenhersteller und unterschiedlicher Preisklassen sind ständig abrufbar. Darüber hinaus profitieren die Filialen von einer zentralen Organisation und Betreuung ihrer IT. Von Düsseldorf aus administriert ein internes Supportteam die Arbeitsplätze aller Standorte und stellt außerdem die Warenwirtschaftslösung zur Verfügung. Dank der Umstellung auf eine moderne Server Based Computing-Umgebung sind Wartung und Support künftig so effizient wie nie zuvor.

  18. Cosmetic Lateral Canthoplasty: Preserving the Lateral Canthal Angle

    PubMed Central

    Lee, Kyu Ho; Choi, Hong Lim; Jeong, Eui Cheol

    2016-01-01

    Cosmetic lateral canthoplasty, in which the size of the eye is increased by extending the palpebral fissure and decreasing the degree of the eye slant, has become a prevalent procedure for East Asians. However, it is not uncommon for there to be complications or unfavorable results after the surgery. With this in mind, the authors have designed a surgical method to reduce complications in cosmetic lateral canthoplasty by preserving the lateral canthal angle. We discuss here the anatomy required for surgery, the surgical methods, and methods for reducing complications during cosmetic lateral canthoplasty. PMID:27462563

  19. Strictly homogeneous laterally complete modules

    NASA Astrophysics Data System (ADS)

    Chilin, V. I.; Karimov, J. A.

    2016-03-01

    Let A be a laterally complete commutative regular algebra and X be a laterally complete A-module. In this paper we introduce a notion of homogeneous and strictly homogeneous A-modules. It is proved that any homogeneous A-module is strictly homogeneous A-module, if the Boolean algebra of all idempotents in A is multi-σ-finite.

  20. The significance of laterality effects.

    PubMed Central

    Warrington, E K; Pratt, R T

    1981-01-01

    Language laterality can be unequivocally ascertained by comparing the effects of unilateral ECT to the right and the left hemisphere. It has been shown in right-handed depressed patients that a unilateral treatment to the left hemisphere resulted in transient dysphasia whereas unilateral ECT to the right hemisphere did not. The language laterality in a small group of left-handed depressed patients has been ascertained. Evidence is presented to show that neither dichotic listening nor hand position for writing provide satisfactory indices of language laterality. The ear advantage was more closely related to strength of sinistrality than to language laterality--that is sidedness appears to overide brainedness. The results favour a spatial attention hypothesis rather than a structural hypothesis as the main determinant of laterality effects. PMID:7229640

  1. A Pascalian lateral drift sensor

    NASA Astrophysics Data System (ADS)

    Jansen, H.

    2016-09-01

    A novel concept of a layer-wise produced semiconductor sensor for precise particle tracking is proposed herein. In contrast to common semiconductor sensors, local regions with increased doping concentration deep in the bulk termed charge guides increase the lateral drift of free charges on their way to the read-out electrode. This lateral drift enables charge sharing independent of the incident position of the traversing particle. With a regular grid of charge guides the lateral charge distribution resembles a normalised Pascal's triangle for particles that are stopped in depths lower than the depth of the first layer of the charge guides. For minimum ionising particles a sum of binomial distributions describes the lateral charge distribution. This concept decouples the achievable sensor resolution from the pitch size as the characteristic length is replaced by the lateral distance of the charge guides.

  2. Lateral Dominance and Reading Disability.

    ERIC Educational Resources Information Center

    Harris, Albert J.

    1979-01-01

    Theory and research on the relation of lateral dominance to the causation of reading disability are reviewed. Both direct and indirect measures of cerebral hemisphere functioning are considered. (SBH)

  3. Hyperaldosteronism: diagnosis, lateralization, and treatment.

    PubMed

    Harvey, Adrian M

    2014-06-01

    Primary hyperaldosteronism is an important and commonly unrecognized secondary cause of hypertension. This article provides an overview of the current literature with respect to screening, diagnosis, and lateralization. Selection and outcomes of medical and surgical treatment are discussed.

  4. Cerebral Laterality and Verbal Processes

    ERIC Educational Resources Information Center

    Sherman, Jay L.; And Others

    1976-01-01

    Research suggests that we process information by way of two distinct and functionally separate coding systems. Their location, somewhat dependent on cerebral laterality, varies in right- and left-handed persons. Tests this dual coding model. (Editor/RK)

  5. Lateral plantar pain: diagnostic considerations.

    PubMed

    Bahel, Aditya; Yu, Joseph S

    2010-07-01

    Injuries that target the bones of the midfoot are important causes of pain. The medial aspect of the midfoot has been extensively studied but the lateral plantar region has not received as much attention. The objective of this article is to review the differential diagnosis of lateral plantar pain, emphasizing on the common mechanisms of injury, and to identify characteristic imaging findings for these pathologic conditions.

  6. Optineurin and amyotrophic lateral sclerosis.

    PubMed

    Maruyama, Hirofumi; Kawakami, Hideshi

    2013-07-01

    Amyotrophic lateral sclerosis is a devastating disease, and thus it is important to identify the causative gene and resolve the mechanism of the disease. We identified optineurin as a causative gene for amyotrophic lateral sclerosis. We found three types of mutations: a homozygous deletion of exon 5, a homozygous Q398X nonsense mutation and a heterozygous E478G missense mutation within its ubiquitin-binding domain. Optineurin negatively regulates the tumor necrosis factor-α-induced activation of nuclear factor kappa B. Nonsense and missense mutations abolished this function. Mutations related to amyotrophic lateral sclerosis also negated the inhibition of interferon regulatory factor-3. The missense mutation showed a cyotoplasmic distribution different from that of the wild type. There are no specific clinical symptoms related to optineurin. However, severe brain atrophy was detected in patients with homozygous deletion. Neuropathologically, an E478G patient showed transactive response DNA-binding protein of 43 kDa-positive neuronal intracytoplasmic inclusions in the spinal and medullary motor neurons. Furthermore, Golgi fragmentation was identified in 73% of this patient's anterior horn cells. In addition, optineurin is colocalized with fused in sarcoma in the basophilic inclusions of amyotrophic lateral sclerosis with fused in sarcoma mutations, and in basophilic inclusion body disease. These findings strongly suggest that optineurin is involved in the pathogenesis of amyotrophic lateral sclerosis.

  7. Borehole optical lateral displacement sensor

    DOEpatents

    Lewis, R.E.

    1998-10-20

    There is provided by this invention an optical displacement sensor that utilizes a reflective target connected to a surface to be monitored to reflect light from a light source such that the reflected light is received by a photoelectric transducer. The electric signal from the photoelectric transducer is then imputed into electronic circuitry to generate an electronic image of the target. The target`s image is monitored to determine the quantity and direction of any lateral displacement in the target`s image which represents lateral displacement in the surface being monitored. 4 figs.

  8. 49 CFR 230.105 - Lateral motion.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Lateral motion. 230.105 Section 230.105... Tenders Running Gear § 230.105 Lateral motion. (a) Condemning limits. The total lateral motion or play... require additional lateral motion. (c) Non-interference with other parts. The lateral motion shall in...

  9. Living Arrangements in Later Life.

    ERIC Educational Resources Information Center

    Frazier, Billie H.

    This document contains a brief bibliography of peer-reviewed literature, with abstracts, on living arrangements in later life. It is one of 12 bibliographies on aging prepared by the National Agricultural Library for its "Pathfinders" series of publications. Topics covered by the other 11 bibliographies include aging parents, adult children,…

  10. Amyotrophic lateral sclerosis mimic syndromes

    PubMed Central

    Ghasemi, Majid

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) misdiagnosis has many broad implications for the patient and the neurologist. Potentially curative treatments exist for certain ALS mimic syndromes, but delay in starting these therapies may have an unfavorable effect on outcome. Hence, it is important to exclude similar conditions. In this review, we discuss some of the important mimics of ALS. PMID:27326363

  11. Lateral facet syndrome of the patella. Lateral restraint analysis and use of lateral resection.

    PubMed

    Johnson, R P

    1989-01-01

    Thirty-eight knees in 34 patients with an average age of 22 years were diagnosed as having lateral facet syndrome (LFS), a painful compressive arthropathy of the lateral facet of the patella. This diagnosis was based on the physical findings of tenderness at the lateral patellofemoral joint line, tenderness over the vastus lateralis obliquus (VLO) tendon just above the patella, a positive medial apprehension test, and marked resistance to medial patellar displacement with the knee flexed 30 degrees. The most common complaints were patellar pain with activity, pain with prolonged knee flexion, intermittent knee swelling, and giving way. At surgery, the VLO, the lateral retinaculum (LR), and the anterior fibers of the iliotibial tract (ITT) were sequentially divided from the lateral border of the patella. Each was temporarily reattached to a cuff of soft tissue left on the patella using surgical clamps to determine its contribution to lateral restraint. The VLO was found to be the primary restraint in one-half of the knees. In one-third of the knees, all three of the structures contributed equally. In six knees, the primary restraint was the anterior fibers of the ITT, whereas the LR was the primary restraint in only two. The distal ends of these three structures were then resected to prevent rescarring and retethering. At a minimum follow-up period of two years, 87% had satisfactory relief of their patellar pain, had returned to normal activities, and had no or minimal physical findings of LFS. The procedure is recommended for patients who have failed other procedures and in those whose symptoms cannot be controlled by activity modification, exercises, bracing, or medication. PMID:2910595

  12. Lateralized processes in face recognition.

    PubMed

    Rhodes, G

    1985-05-01

    In this paper a model is presented in which face recognition is analysed into several stages, each of which may be independently lateralized. Evidence is reviewed which suggests that lateralization is important at all stages of processing a face. Early visuospatial processing, and the creation and comparison of facial representations, appear to be carried out more efficiently by the right hemisphere. Comparisons based on discrete, namable features of faces may yield a left hemisphere advantage. It is also proposed that faces may activate semantic information, including names, more efficiently in the left hemisphere. The model is useful in resolving inconsistencies in the degree and direction of asymmetries found in face-recognition tasks. Suggestions are also made for future research.

  13. Preserving Dignity in Later Life.

    PubMed

    São José, José Manuel

    2016-09-01

    This article examines how elders who receive social care in the community experience loss of dignity and how they preserve their dignity. Qualitative research revealed that loss of dignity is a major concern for these elders and that they preserve their dignity differently, ranging from actively engaging with life to detaching themselves from life. We conclude that, in later life, preserving dignity while receiving social care differs from preserving dignity in the context of health care, especially health care provided in institutional settings. Furthermore, preserving dignity in later life, while receiving social care, is a complex process, depending not only on performing activities and individual action and responsibility, but also on other actions, some of them involving a certain inactivity/passivity, and interactions with others, especially caregivers. This article offers some insights to developing better policies and care practices for promoting dignity in the context of community-based social care.

  14. Congenital lateral abdominal wall hernia.

    PubMed

    Montes-Tapia, Fernando; Cura-Esquivel, Idalia; Gutiérrez, Susana; Rodríguez-Balderrama, Isaías; de la O-Cavazos, Manuel

    2016-08-01

    Congenital abdominal wall defects that are located outside of the anterior wall are extremely rare and difficult to classify because there are no well accepted guidelines. There are two regions outside of the anterior wall: the flank or lateral wall; and the lumbar region. We report the case of a patient with an oval 3 cm-diameter hernia defect located above the anterior axillary line, which affects all layers of the muscular wall. An anorectal malformation consisting of a recto-vestibular fistula was also identified, and chest X-ray showed dextrocardia. The suggested treatment is repair of the defect before 1 year of age. Given that the anomalies described may accompany lateral abdominal wall hernia, it is important to diagnose and treat the associated defects.

  15. Preserving Dignity in Later Life.

    PubMed

    São José, José Manuel

    2016-09-01

    This article examines how elders who receive social care in the community experience loss of dignity and how they preserve their dignity. Qualitative research revealed that loss of dignity is a major concern for these elders and that they preserve their dignity differently, ranging from actively engaging with life to detaching themselves from life. We conclude that, in later life, preserving dignity while receiving social care differs from preserving dignity in the context of health care, especially health care provided in institutional settings. Furthermore, preserving dignity in later life, while receiving social care, is a complex process, depending not only on performing activities and individual action and responsibility, but also on other actions, some of them involving a certain inactivity/passivity, and interactions with others, especially caregivers. This article offers some insights to developing better policies and care practices for promoting dignity in the context of community-based social care. PMID:27456751

  16. Lateral gene transfer in eukaryotes.

    PubMed

    Andersson, J O

    2005-06-01

    Lateral gene transfer -- the transfer of genetic material between species -- has been acknowledged as a major mechanism in prokaryotic genome evolution for some time. Recently accumulating data indicate that the process also occurs in the evolution of eukaryotic genomes. However, there are large rate variations between groups of eukaryotes; animals and fungi seem to be largely unaffected, with a few exceptions, while lateral gene transfer frequently occurs in protists with phagotrophic lifestyles, possibly with rates comparable to prokaryotic organisms. Gene transfers often facilitate the acquisition of functions encoded in prokaryotic genomes by eukaryotic organisms, which may enable them to colonize new environments. Transfers between eukaryotes also occur, mainly into larger phagotrophic eukaryotes that ingest eukaryotic cells, but also between plant lineages. These findings have implications for eukaryotic genomic research in general, and studies of the origin and phylogeny of eukaryotes in particular.

  17. Lateral dampers for thrust bearings

    NASA Technical Reports Server (NTRS)

    Hibner, D. H.; Szafir, D. R.

    1985-01-01

    The development of lateral damping schemes for thrust bearings was examined, ranking their applicability to various engine classes, selecting the best concept for each engine class and performing an in-depth evaluation. Five major engine classes were considered: large transport, military, small general aviation, turboshaft, and non-manrated. Damper concepts developed for evaluation were: curved beam, constrained and unconstrained elastomer, hybrid boost bearing, hydraulic thrust piston, conical squeeze film, and rolling element thrust face.

  18. Cerebral lateralization in simultaneous interpretation.

    PubMed

    Fabbro, F; Gran, L; Basso, G; Bava, A

    1990-07-01

    Cerebral asymmetries for L1 (Italian), L2 (English), and L3 (French, German, Spanish, or Russian) were studied, by using a verbal-manual interference paradigm, in a group of Italian right-handed polyglot female students at the Scuola Superiore di Lingue Moderne per Interpreti e Traduttori (SSLM-School for Interpreters and Translators) of the University of Trieste and in a control group of right-handed monolingual female students at the Medical School of the University of Trieste. In an automatic speech production task no significant cerebral lateralization was found for the mother tongue (L1) either in the interpreting students or in the control group; the interpreting students were not significantly lateralized for the third language (L3), while weak left hemispheric lateralization was shown for L2. A significantly higher degree of verbal-manual interference was found for L1 than for L2 and L3. A significantly higher disruption rate occurred in the meaning-based mode of simultaneous interpretation (from L2 into L1 and vice versa) than in the word-for-word mode (from L2 into L1 and vice versa). No significant overall or hemispheric differences were found during simultaneous interpretation from L1 into L2 or from L2 into L1. PMID:2207622

  19. 49 CFR 229.63 - Lateral motion.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Lateral motion. 229.63 Section 229.63....63 Lateral motion. (a) Except as provided in paragraph (b), the total uncontrolled lateral motion... powered axles. (b) The total uncontrolled lateral motion may not exceed 11/4 inches on the center axle...

  20. Lateral movement of auxin in phototropism.

    PubMed

    Dela Fuente, R K; Leopold, A C

    1968-07-01

    Lateral movement of indoleacetic acid-1-(14)C in corn coleoptiles was measured as radioactivity moving laterally following unilateral application of the auxin. The data suggest that there is an endogenous lateral movement of auxin, and that phototropic stimulation of the coleoptile depresses lateral movement towards the light and enhances lateral movement away from the light. The lateral movement was found to be principally as indoleacetic acid. In experiments using sunflower hypocotyl sections, evidence is also presented to support the suggestion that lateral redistribution of auxin may be effected by a deflection of auxin around a barrier to basipetal transport.

  1. Direct lateral maneuvers in hawkmoths.

    PubMed

    Greeter, Jeremy S M; Hedrick, Tyson L

    2016-01-01

    We used videography to investigate direct lateral maneuvers, i.e. 'sideslips', of the hawkmoth Manduca sexta. M. sexta sideslip by rolling their entire body and wings to reorient their net force vector. During sideslip they increase net aerodynamic force by flapping with greater amplitude, (in both wing elevation and sweep), allowing them to continue to support body weight while rolled. To execute the roll maneuver we observed in sideslips, they use an asymmetric wing stroke; increasing the pitch of the roll-contralateral wing pair, while decreasing that of the roll-ipsilateral pair. They also increase the wing sweep amplitude of, and decrease the elevation amplitude of, the contralateral wing pair relative to the ipsilateral pair. The roll maneuver unfolds in a stairstep manner, with orientation changing more during downstroke than upstroke. This is due to smaller upstroke wing pitch angle asymmetries as well as increased upstroke flapping counter-torque from left-right differences in global reference frame wing velocity about the moth's roll axis. Rolls are also opposed by stabilizing aerodynamic moments from lateral motion, such that rightward roll velocity will be opposed by rightward motion. Computational modeling using blade-element approaches confirm the plausibility of a causal linkage between the previously mentioned wing kinematics and roll/sideslip. Model results also predict high degrees of axial and lateral damping. On the time scale of whole and half wing strokes, left-right wing pair asymmetries directly relate to the first, but not second, derivative of roll. Collectively, these results strongly support a roll-based sideslip with a high degree of roll damping in M. sexta. PMID:26740573

  2. Direct lateral maneuvers in hawkmoths

    PubMed Central

    Greeter, Jeremy S. M.; Hedrick, Tyson L.

    2016-01-01

    ABSTRACT We used videography to investigate direct lateral maneuvers, i.e. ‘sideslips’, of the hawkmoth Manduca sexta. M. sexta sideslip by rolling their entire body and wings to reorient their net force vector. During sideslip they increase net aerodynamic force by flapping with greater amplitude, (in both wing elevation and sweep), allowing them to continue to support body weight while rolled. To execute the roll maneuver we observed in sideslips, they use an asymmetric wing stroke; increasing the pitch of the roll-contralateral wing pair, while decreasing that of the roll-ipsilateral pair. They also increase the wing sweep amplitude of, and decrease the elevation amplitude of, the contralateral wing pair relative to the ipsilateral pair. The roll maneuver unfolds in a stairstep manner, with orientation changing more during downstroke than upstroke. This is due to smaller upstroke wing pitch angle asymmetries as well as increased upstroke flapping counter-torque from left-right differences in global reference frame wing velocity about the moth's roll axis. Rolls are also opposed by stabilizing aerodynamic moments from lateral motion, such that rightward roll velocity will be opposed by rightward motion. Computational modeling using blade-element approaches confirm the plausibility of a causal linkage between the previously mentioned wing kinematics and roll/sideslip. Model results also predict high degrees of axial and lateral damping. On the time scale of whole and half wing strokes, left-right wing pair asymmetries directly relate to the first, but not second, derivative of roll. Collectively, these results strongly support a roll-based sideslip with a high degree of roll damping in M. sexta. PMID:26740573

  3. Direct lateral maneuvers in hawkmoths.

    PubMed

    Greeter, Jeremy S M; Hedrick, Tyson L

    2016-01-01

    We used videography to investigate direct lateral maneuvers, i.e. 'sideslips', of the hawkmoth Manduca sexta. M. sexta sideslip by rolling their entire body and wings to reorient their net force vector. During sideslip they increase net aerodynamic force by flapping with greater amplitude, (in both wing elevation and sweep), allowing them to continue to support body weight while rolled. To execute the roll maneuver we observed in sideslips, they use an asymmetric wing stroke; increasing the pitch of the roll-contralateral wing pair, while decreasing that of the roll-ipsilateral pair. They also increase the wing sweep amplitude of, and decrease the elevation amplitude of, the contralateral wing pair relative to the ipsilateral pair. The roll maneuver unfolds in a stairstep manner, with orientation changing more during downstroke than upstroke. This is due to smaller upstroke wing pitch angle asymmetries as well as increased upstroke flapping counter-torque from left-right differences in global reference frame wing velocity about the moth's roll axis. Rolls are also opposed by stabilizing aerodynamic moments from lateral motion, such that rightward roll velocity will be opposed by rightward motion. Computational modeling using blade-element approaches confirm the plausibility of a causal linkage between the previously mentioned wing kinematics and roll/sideslip. Model results also predict high degrees of axial and lateral damping. On the time scale of whole and half wing strokes, left-right wing pair asymmetries directly relate to the first, but not second, derivative of roll. Collectively, these results strongly support a roll-based sideslip with a high degree of roll damping in M. sexta.

  4. Vision assisted aircraft lateral navigation

    NASA Astrophysics Data System (ADS)

    Mohideen, Mohamed Ibrahim; Ramegowda, Dinesh; Seiler, Peter

    2013-05-01

    Surface operation is currently one of the least technologically equipped phases of aircraft operation. The increased air traffic congestion necessitates more aircraft operations in degraded weather and at night. The traditional surface procedures worked well in most cases as airport surfaces have not been congested and airport layouts were less complex. Despite the best efforts of FAA and other safety agencies, runway incursions continue to occur frequently due to incorrect surface operation. Several studies conducted by FAA suggest that pilot induced error contributes significantly to runway incursions. Further, the report attributes pilot's lack of situational awareness - local (e.g., minimizing lateral deviation), global (e.g., traffic in the vicinity) and route (e.g., distance to next turn) - to the problem. An Enhanced Vision System (EVS) is one concept that is being considered to resolve these issues. These systems use on-board sensors to provide situational awareness under poor visibility conditions. In this paper, we propose the use of an Image processing based system to estimate the aircraft position and orientation relative to taxiway markings to use as lateral guidance aid. We estimate aircraft yaw angle and lateral offset from slope of the taxiway centerline and horizontal position of vanishing line. Unlike automotive applications, several cues such as aircraft maneuvers along assigned route with minimal deviations, clear ground markings, even taxiway surface, limited aircraft speed are available and enable us to implement significant algorithm optimizations. We present experimental results to show high precision navigation accuracy with sensitivity analysis with respect to camera mount, optics, and image processing error.

  5. Laterally Mounted Azobenzenes on Platforms.

    PubMed

    Hammerich, Melanie; Herges, Rainer

    2015-11-20

    Triazatriangulenium ions have previously been used as platforms to prepare self-assembled monolayers of functional molecules such as azobenzenes with vertical orientation and that are free-standing on gold surfaces. We have now prepared azobenzenes that are spanned between two posts which are attached on two platforms. Absorbed on a gold surface, the azobenzene should be laterally oriented at a distance of more than 4 Å above and thus electronically decoupled from the surface, and the system should perform a muscle-type movement upon isomerization. PMID:26551306

  6. Lateralization of aggression in fish.

    PubMed

    Bisazza, Angelo; de Santi, Andrea

    2003-05-15

    Recent research has suggested that lateralization of aggressive behaviors could follow an homogeneous pattern among all vertebrates. A left eye/right hemisphere dominance in eliciting aggressive responses has been demonstrated for all groups of tetrapods but teleost fish for which data is lacking. Here we studied differential eye use during aggressive interactions in three species of teleosts: Gambusia holbrooki, Xenotoca eiseni and Betta splendens. In the first experiment we checked for lateralization in the use of the eyes while the subject was attacking its own mirror image. In order to confirm the results, other tests were performed on two species and eye preference was scored during attacks or displays directed toward a live rival. All three species showed a marked preference for using the right eye when attacking a mirror image or a live rival. Thus, the direction of asymmetry in fish appears the opposite to that shown by all the other groups of vertebrates. Hypotheses on the origin of the difference are discussed.

  7. Lateralization of aggression in fish.

    PubMed

    Bisazza, Angelo; de Santi, Andrea

    2003-05-15

    Recent research has suggested that lateralization of aggressive behaviors could follow an homogeneous pattern among all vertebrates. A left eye/right hemisphere dominance in eliciting aggressive responses has been demonstrated for all groups of tetrapods but teleost fish for which data is lacking. Here we studied differential eye use during aggressive interactions in three species of teleosts: Gambusia holbrooki, Xenotoca eiseni and Betta splendens. In the first experiment we checked for lateralization in the use of the eyes while the subject was attacking its own mirror image. In order to confirm the results, other tests were performed on two species and eye preference was scored during attacks or displays directed toward a live rival. All three species showed a marked preference for using the right eye when attacking a mirror image or a live rival. Thus, the direction of asymmetry in fish appears the opposite to that shown by all the other groups of vertebrates. Hypotheses on the origin of the difference are discussed. PMID:12742249

  8. Deconvolution of Lateral Shear Interferograms

    NASA Astrophysics Data System (ADS)

    Ambrose, Joseph George

    1994-01-01

    This dissertation develops and presents an existing but little known method to provide an exact solution to the Wavefront Difference Equation routinely encountered in the reduction of Lateral Shear Interferograms (LSI). The method first suggested by Dr. Roland Shack treats LSI as a convolution of the wavefront with an odd impulse pair. This representation casts the Lateral Shear problem in terms of Fourier optics operators and filters with a simplified treatment of the reduction of the LSI possible. This work extends the original proposal applied to line scans of wavefronts to full two-dimensional recovery of the wavefront along with developing the associated mathematical theory and computer code to efficiently execute the wavefront reduction. Further, a number of applications of the wavefront reduction technique presented here are developed. The applications of the filtering technique developed here include optical imaging systems exhibiting the primary aberrations, a model of residual tool marks after fabrication and propagation of an optical probe through atmospheric turbulence. The computer program developed in this work resides on a PC and produces accurate results to a 1/500 wave when compared to ray traced input wavefronts. The combination of the relatively simple concept providing the basis of the reduction technique with the highly accurate results over a wide range of input wavefronts makes this a timely effort. Finally, the reduction technique can be applied to the accurate testing of aspheric optical components.

  9. Deconvolution of lateral shear interferograms

    NASA Astrophysics Data System (ADS)

    Ambrose, Joseph George

    This dissertation develops and presents an existing but little known method to provide an exact solution to the wavefront difference equation routinely encountered in the reduction of lateral shear interferograms (LSI). The method first suggested by Dr. Roland Shack treats LSI as a convolution of the wavefront with an odd impulse pair. This representation casts the lateral shear problem in terms of Fourier optics operators and filters with a simplified treatment of the reduction of the LSI possible. This work extends the original proposal applied to line scans of wavefronts to full two-dimensional recovery of the wavefront along with developing the associated mathematical theory and computer code to efficiently execute the wavefront reduction. Further, a number of applications of the wavefront reduction technique presented here are developed. The applications of the filtering technique developed here include optical imaging systems exhibiting the primary aberrations, a model of residual tool marks after fabrication, and propagation of an optical probe through atmospheric turbulence. The computer program developed resides on a PC and produces accurate results to a 1/500 wave when compared to ray traced input wavefronts. The combination of the relatively simple concept providing the basis of the reduction technique with the highly accurate results over a wide range of input wavefronts makes this a timely effort. Finally, the reduction technique can be applied to the accurate testing of aspheric optical components.

  10. LATERAL EPICONDYLITIS OF THE ELBOW

    PubMed Central

    Cohen, Marcio; da Rocha Motta Filho, Geraldo

    2015-01-01

    Lateral epicondylitis, also known as tennis elbow, is a common condition that is estimated to affect 1% to 3% of the population. The word epicondylitis suggests inflammation, although histological analysis on the tissue fails to show any inflammatory process. The structure most commonly affected is the origin of the tendon of the extensor carpi radialis brevis and the mechanism of injury is associated with overloading. Nonsurgical treatment is the preferred method, and this includes rest, physiotherapy, cortisone infiltration, platelet-rich plasma injections and use of specific immobilization. Surgical treatment is recommended when functional disability and pain persist. Both the open and the arthroscopic surgical technique with resection of the degenerated tendon tissue present good results in the literature. PMID:27047843

  11. Lateral epicondylosis: emerging management options.

    PubMed

    Thompson, Carolyn; Visco, Christopher

    2015-01-01

    Lateral epicondylosis is one of the most prevalent disorders of the arm and results in significantly decreased function among the workforce and athletes. Historically, the disorder has been diagnosed clinically and treated as an inflammatory entity. Management strategies have included anti-inflammatory medications and techniques, including oral nonsteroidal anti-inflammatories, injected corticosteroid, and physical therapy with modalities. More recent literature postulates a degenerative or compressive etiology, directing some clinicians to try new, more regenerative management strategies such as platelet-rich plasma and stem cell injections. To date, literature evaluating these new treatment methods has shown positive results, although no definitive conclusions can be drawn. More research is needed to evaluate these new treatment methods, and a new look at the diagnosis of the disorder with ultrasound imaging may be reasonable to consider. PMID:25968855

  12. Teen Obesity May Mean Liver Disease Later

    MedlinePlus

    ... news/fullstory_159416.html Teen Obesity May Mean Liver Disease Later Study found risk increased as weight went ... obese could be at increased risk for severe liver disease later in life, a new study suggests. The ...

  13. Hemispheric Laterality in Music and Math

    ERIC Educational Resources Information Center

    Szirony, Gary Michael; Burgin, John S.; Pearson, L. Carolyn

    2008-01-01

    Hemispheric laterality may be a useful concept in teaching, learning, training, and in understanding more about human development. To address this issue, a measure of hemispheric laterality was compared to musical and mathematical ability. The Human Information Processing Survey (HIPS) instrument, designed to measure hemispheric laterality, was…

  14. Sewer Lateral Electro Scan Field Verification Pilot

    EPA Science Inventory

    Abstract:WERF selected a proposed research project to field test an emerging technology for inspecting sanitary sewer lateral pipes. The technology is called Electro Scan and is used to find defects in laterals that allow the infiltration of groundwater into the lateral. Electro ...

  15. Developmental dyscalculia and brain laterality.

    PubMed

    Shalev, R S; Manor, O; Amir, N; Wertman-Elad, R; Gross-Tsur, V

    1995-06-01

    The correlation between arithmetic dysfunction and brain laterality was studied in 25 children with developmental dyscalculia (DD). The children were tested on a standardized arithmetic battery and underwent a neurological and neuro-psychological evaluation. A diagnosis of left hemisphere dysfunction (n = 13) was based on right side soft neurological signs, performance IQ (PIQ) > verbal IQ (VIQ), dyslexia and intact visuo-spatial functions. The criteria for right hemisphere dysfunction (n = 12) were left body signs, VIQ > PIQ, impaired visuo-spatial functions and normal language skills. The groups were similar for age, gender, and socio-economic status. Our results showed that both groups scored more than 2 SD below the mean adjusted score on the arithmetic battery, but the left group was significantly worse in 3 areas: mastery of addition/subtraction, complex multiplication and division and visuo-spatial errors (p < 0.05). The data indicate that dysfunction of either hemisphere hampers arithmetic acquisition, but arithmetic impairment is more profound with left hemisphere dysfunction. PMID:7555012

  16. The multifunctional lateral geniculate nucleus.

    PubMed

    Weyand, Theodore G

    2016-02-01

    Providing the critical link between the retina and visual cortex, the well-studied lateral geniculate nucleus (LGN) has stood out as a structure in search of a function exceeding the mundane 'relay'. For many mammals, it is structurally impressive: Exquisite lamination, sophisticated microcircuits, and blending of multiple inputs suggest some fundamental transform. This impression is bolstered by the fact that numerically, the retina accounts for a small fraction of its input. Despite such promise, the extent to which an LGN neuron separates itself from its retinal brethren has proven difficult to appreciate. Here, I argue that whereas retinogeniculate coupling is strong, what occurs in the LGN is judicious pruning of a retinal drive by nonretinal inputs. These nonretinal inputs reshape a receptive field that under the right conditions departs significantly from its retinal drive, even if transiently. I first review design features of the LGN and follow with evidence for 10 putative functions. Only two of these tend to surface in textbooks: parsing retinal axons by eye and functional group and gating by state. Among the remaining putative functions, implementation of the principle of graceful degradation and temporal decorrelation are at least as interesting but much less promoted. The retina solves formidable problems imposed by physics to yield multiple efficient and sensitive representations of the world. The LGN applies context, increasing content, and gates several of these representations. Even if the basic concentric receptive field remains, information transmitted for each LGN spike relative to each retinal spike is measurably increased. PMID:26479339

  17. Retroviruses and amyotrophic lateral sclerosis

    PubMed Central

    Alfahad, Tariq; Nath, Avindra

    2013-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive, invariably fatal neurologic disorder resulting from upper and lower motor neuron degeneration, which typically develops during the sixth or seventh decade of life, and is diagnosed based on standard clinical criteria. Its underlying cause remains undetermined. The disease may occur with increased frequency within certain families, often in association with specific genomic mutations, while some sporadic cases have been linked to environmental toxins or trauma. Another possibility, first proposed in the 1970s, is that retroviruses play a role in pathogenesis. In this paper, we review the published literature for evidence that ALS is associated either with infection by an exogenous retrovirus or with the expression of human endogenous retroviral (HERV) sequences in cells of the central nervous system. A small percentage of persons infected with the human immunodeficiency virus-1 (HIV-1) or human T cell leukemia virus-1 (HTLV-1) develop ALS-like syndromes. While HTLV-1 associated ALS-like syndrome has several features that may distinguish it from classical ALS, HIV-infected patients may develop neurological manifestations that resemble classical ALS although it occurs at a younger age and they may show a dramatic improvement following the initiation of antiretroviral therapy. However, most patients with probable or definite ALS show no evidence of HIV-1 or HTLV-1 infection. In contrast, recent reports have shown a stronger association with HERV, as analysis of serum samples, and postmortem brain tissue from a number of patients with a classical ALS has revealed significantly increased expression of HERV-K, compared to controls. These findings suggest that endogenous retroviral elements are involved in the pathophysiology of ALS, but there is no evidence that they are the primary cause of the syndrome. PMID:23707220

  18. Summary of lateral-control research

    NASA Technical Reports Server (NTRS)

    Toll, Thomas A

    1947-01-01

    A summary has been made of the available information on lateral control. A discussion is given of the criterions used in lateral-control specifications, of the factors involved in obtaining satisfactory lateral control, and of the methods employed in making lateral-control investigations in flight and in wind tunnels. The available data on conventional flap-type ailerons having various types of aerodynamic balance are presented in a form convenient for use in design. The characteristics of spoiler devices and booster mechanisms are discussed. The effects of Mach number, boundary layer, and distortion of the wing or of the lateral-control system are considered insofar as the available information permits. An example is included to illustrate the use of the design data. The limitations of the available information and some of the lateral-control problems that remain to be solved are indicated.

  19. Artificial lateral line canal for hydrodynamic detection

    NASA Astrophysics Data System (ADS)

    Yang, Yingchen; Klein, Adrian; Bleckmann, Horst; Liu, Chang

    2011-07-01

    Fish use their lateral line system to detect minute water motions. The lateral line consists of superficial neuromasts and canal neuromasts. The response properties of canal neuromasts differ from those of superficial ones. Here, we report the design, fabrication, and characterization of an artificial lateral line canal system. The characterization was done under various fluid conditions, including dipolar excitation and turbulent flow. The experimental results with dipole excitation match well with a mathematical model. Canal sensors also demonstrate significantly better noise immunity compared with superficial ones. Canal-type artificial lateral lines may become important for underwater flow sensing.

  20. Vannevar Bush: Fifty Years Later

    NASA Astrophysics Data System (ADS)

    Lagowski, J. J.

    1995-12-01

    It is ironic that the 50th anniversary year of Vannevar Bush's Report to President Truman entitled "Science the Endless Frontier", which put into motion the eminently successful current system of education of scientists in this country occurs at a time when serious questions are being asked about the usefulness of that very system. Bush viewed his proposal to establish a national research foundation (later to be called the National Science Foundation) as a "social compact." Judgment of scientific merit would be delegated to expert peers in return for scientific progress, which would ultimately benefit the nation in terms of scientific needs--military security, economic productivity, and enhanced quality of life. Bush wanted the funding of basic research intertwined with training, and preferred to use universities for this purpose rather than industrial or national labs. Bush viewed college and university scientists as teachers and investigators. He believed university-based research would uniquely encourage and engage the next generation of scientists as no other institutional arrangement could. Bush did not trust industry's commitment to basic research, an instinct that proved prophetic. The academic reserve of scientists (PhD's in training and postdoctoral students) that existed before World War II, and upon which the United States could draw for its needs, which were primarily associated with defense efforts, was probably one of the defining factors in Bush's suggested strategy. Currently, that reserve of talent has gotten so large that it is the obvious throttle in the pipeline slowing the continued development of the university research enterprise. Since 1977, the rate at which we have trained new scientists exceeds an average of 4% annually. Since 1987, the "science work force"--PhD's--has grown at three times the rate of the general labor supply. Temporary positions for postdoctoral scientists have grown even faster (over 5% per year since 1989). To compound

  1. Laterality and Dyslexia: A Critical View.

    ERIC Educational Resources Information Center

    Hiscock, Merrill; Kinsbourne, Marcel

    1982-01-01

    Research is reviewed concerning the current state of knowledge about normal hemispheric specialization; distinctions among such terms as dominance, laterality, and lateralization; and models of abnormal cerebral organization in dyslexic children. The question of dyslexic subtypes is undertaken along such dimensions as handedness, eyedness, and…

  2. Laterality and Reading Proficiency in Children.

    ERIC Educational Resources Information Center

    Leong, Che Kan

    1980-01-01

    Discusses some current concepts of the laterality/reading relationship. An overview of Samuel T. Orton's hypotheses of cerebral dominance and "strephosymbolia" is provided, and both visual half-field and dichotic listening studies as direct, empirical tests of laterality are discussed. (MKM)

  3. Aeromonas hydrophila Lateral Flagellar Gene Transcriptional Hierarchy

    PubMed Central

    Wilhelms, Markus; Gonzalez, Victor; Merino, Susana

    2013-01-01

    Aeromonas hydrophila AH-3 lateral flagella are not assembled when bacteria grow in liquid media; however, lateral flagellar genes are transcribed. Our results indicate that A. hydrophila lateral flagellar genes are transcribed at three levels (class I to III genes) and share some similarities with, but have many important differences from, genes of Vibrio parahaemolyticus. A. hydrophila lateral flagellum class I gene transcription is σ70 dependent, which is consistent with the fact that lateral flagellum is constitutively transcribed, in contrast to the characteristics of V. parahaemolyticus. The fact that multiple genes are included in class I highlights that lateral flagellar genes are less hierarchically transcribed than polar flagellum genes. The A. hydrophila lafK-fliEJL gene cluster (where the subscript L distinguishes genes for lateral flagella from those for polar flagella) is exclusively from class I and is in V. parahaemolyticus class I and II. Furthermore, the A. hydrophila flgAMNL cluster is not transcribed from the σ54/LafK-dependent promoter and does not contain class II genes. Here, we propose a gene transcriptional hierarchy for the A. hydrophila lateral flagella. PMID:23335410

  4. Lateral displacement and rotational displacement sensor

    DOEpatents

    Duden, Thomas

    2014-04-22

    A position measuring sensor formed from opposing sets of capacitor plates measures both rotational displacement and lateral displacement from the changes in capacitances as overlapping areas of capacitors change. Capacitances are measured by a measuring circuit. The measured capacitances are provided to a calculating circuit that performs calculations to obtain angular and lateral displacement from the capacitances measured by the measuring circuit.

  5. Minimizing energy requirements for sprinkler laterals

    SciTech Connect

    Kincaid, D.C.

    1985-01-01

    A computer model was developed to utilize single sprinkler pattern tests in simulating stationary lateral sprinkler systems operating under variable wind conditions. The performance of a low pressure nozzle was compared to that of a standard high pressure round nozzle on a typical multiple set lateral system.

  6. Gender and Marital Happiness in Later Life

    ERIC Educational Resources Information Center

    Kaufman, Gayle; Taniguchi, Hiromi

    2006-01-01

    In this study, the authors examine the effect of gender ideology on marital happiness in later life. Studies of marital satisfaction in later life have tended to neglect such attitudes, although they have received increasing attention in the literature on younger marriages. The authors use data from married individuals who range in age from 51 to…

  7. Later Life: A Time to Learn

    ERIC Educational Resources Information Center

    Russell, Helen

    2008-01-01

    In this article, an emerging framework for investigating and interpreting the experiences of learning in later life is presented. This framework is contextualized by a study in which the lived experiences of later-life computer learners were investigated. Significant ontological and existential interpretations from the study provided insights into…

  8. Ultrasonographic Differentiation of Lateral Elbow Pain.

    PubMed

    Obuchowicz, R; Bonczar, M

    2016-05-01

    Lateral elbow pain is often attributed to degenerative or posttraumatic impairment of the common extensor tendon. Ultrasonography assesses the soft tissue structures of the lateral elbow, allowing the differentiation between various underlying processes, including angiofibroblastic degeneration, hyaline degeneration, and inflammation, and exclusion of other possible causes of pain such as posterior interosseous and lateral antebrachial nerve compression. Furthermore, the real-time imaging nature of ultrasonography enables the detection of impingement of the lateral synovial fold, degenerative changes in the elbow recess, and elbow posterolateral instability during dynamic maneuvers. Ultrasonography is widely accessible and well tolerated by patients, making it a perfect method for establishing an initial diagnosis and monitoring the healing process. This review describes the possible causes of lateral elbow pain and their ultrasonographic differentiation. PMID:27689169

  9. Ultrasonographic Differentiation of Lateral Elbow Pain

    PubMed Central

    Obuchowicz, R.; Bonczar, M.

    2016-01-01

    Lateral elbow pain is often attributed to degenerative or posttraumatic impairment of the common extensor tendon. Ultrasonography assesses the soft tissue structures of the lateral elbow, allowing the differentiation between various underlying processes, including angiofibroblastic degeneration, hyaline degeneration, and inflammation, and exclusion of other possible causes of pain such as posterior interosseous and lateral antebrachial nerve compression. Furthermore, the real-time imaging nature of ultrasonography enables the detection of impingement of the lateral synovial fold, degenerative changes in the elbow recess, and elbow posterolateral instability during dynamic maneuvers. Ultrasonography is widely accessible and well tolerated by patients, making it a perfect method for establishing an initial diagnosis and monitoring the healing process. This review describes the possible causes of lateral elbow pain and their ultrasonographic differentiation. PMID:27689169

  10. Ultrasonographic Differentiation of Lateral Elbow Pain

    PubMed Central

    Obuchowicz, R.; Bonczar, M.

    2016-01-01

    Lateral elbow pain is often attributed to degenerative or posttraumatic impairment of the common extensor tendon. Ultrasonography assesses the soft tissue structures of the lateral elbow, allowing the differentiation between various underlying processes, including angiofibroblastic degeneration, hyaline degeneration, and inflammation, and exclusion of other possible causes of pain such as posterior interosseous and lateral antebrachial nerve compression. Furthermore, the real-time imaging nature of ultrasonography enables the detection of impingement of the lateral synovial fold, degenerative changes in the elbow recess, and elbow posterolateral instability during dynamic maneuvers. Ultrasonography is widely accessible and well tolerated by patients, making it a perfect method for establishing an initial diagnosis and monitoring the healing process. This review describes the possible causes of lateral elbow pain and their ultrasonographic differentiation.

  11. Model to Design Drip Hose Lateral Line

    NASA Astrophysics Data System (ADS)

    Ludwig, Rafael; Cury Saad, João Carlos

    2014-05-01

    Introduction The design criterion for non-pressure compensating drip hose is normally to have 10% of flow variation (Δq) in the lateral line, corresponding to 20% of head pressure variation (ΔH). Longer lateral lines in drip irrigation systems using conventional drippers provide cost reduction, but it is necessary to obtain to the uniformity of irrigation [1]. The use of Δq higher levels can provide longer lateral lines. [4] proposes the use of a 30% Δq and he found that this value resulted in distribution uniformity over 80%. [1] considered it is possible to extend the lateral line length using two emitters spacing in different section. He assumed that the spacing changing point would be at 40% of the total length, because this is approximately the location of the average flow according with [2]. [3] found that, for practical purposes, the average pressure is located at 40% of the length of the lateral line and that until this point it has already consumed 75% of total pressure head loss (hf ). In this case, the challenge for designers is getting longer lateral lines with high values of uniformity. Objective The objective of this study was to develop a model to design longer lateral lines using non-pressure compensating drip hose. Using the developed model, the hypotheses to be evaluated were: a) the use of two different spacing between emitters in the same lateral line allows longer length; b) it is possible to get longer lateral lines using high values of pressure variation in the lateral lines since the distribution uniformity stays below allowable limits. Methodology A computer program was developed in Delphi® based on the model developed and it is able to design lateral lines in level using non-pressure compensating drip hose. The input data are: desired distribution uniformity (DU); initial and final pressure in the lateral line; coefficients of relationship between emitter discharge and pressure head; hose internal diameter; pipe cross-sectional area

  12. Experiments and analysis of lateral piezoresistance gauges

    SciTech Connect

    Wong, M.K.W.

    1993-07-01

    The response of lateral piezoresistance gauges to shock wave uniaxial strain loading has been examined in a combined experimental and calculational effort. Plate impact experiments provided lateral gauge data which were analyzed using quasi-static and dynamic inclusion analyses. Experimental data showed that the response of the lateral gauge output depended upon the matrix material and gauge emplacement method. The calculations indicated that these differences were due to complex gauge-matrix interactions. These interactions were influenced by the stress and strain distributions in and around the gauge, plasticity effects, properties of the gauge and matrix materials, and emplacement conditions.

  13. Cosmetic Lateral Canthoplasty: Lateral Canthoplasty to Lengthen the Lateral Canthal Angle and Correct the Outer Tail of the Eye

    PubMed Central

    Yun, Byung Min

    2016-01-01

    There are many women who want larger and brighter eyes that will give a favorable impression. Surgical methods that make the eye larger and brighter include double eyelidplasty, epicanthoplasty, as well as lateral canthoplasty. Double eyelidplasty produces changes in the vertical dimension of the eyes, whereas epicanthoplasty and lateral canthoplasty create changes in the horizontal dimension of the eyes. Epicanthoplasty, a surgical procedure which enlarges the eye horizontally, is performed at the inner corner of the eye, whereas lateral canthoplasty enlarges the outer edge of the eye. In particular, if the slant of the palpebral fissure is raised and the horizontal dimension of the palpebral fissure is short, adjusting the slant of the palpebral fissure through lateral canthoplasty can achieve an enlargement of eye width and smoother features. Depending on the patient's condition, even better results can be achieved if this procedure is performed in conjunction with other procedures, such as double eyelidplasty, epicanthoplasty, eye roll formation surgery, fat graft, and facial bone contouring surgery. In this paper, the authors will introduce in detail their surgical method for a cosmetic lateral canthoplasty that lengthens the lateral canthal angle and corrects the outer tail of the eyes, in order to ease the unfavorable impression. PMID:27462564

  14. Cosmetic Lateral Canthoplasty: Lateral Canthoplasty to Lengthen the Lateral Canthal Angle and Correct the Outer Tail of the Eye.

    PubMed

    Chae, Soo Wook; Yun, Byung Min

    2016-07-01

    There are many women who want larger and brighter eyes that will give a favorable impression. Surgical methods that make the eye larger and brighter include double eyelidplasty, epicanthoplasty, as well as lateral canthoplasty. Double eyelidplasty produces changes in the vertical dimension of the eyes, whereas epicanthoplasty and lateral canthoplasty create changes in the horizontal dimension of the eyes. Epicanthoplasty, a surgical procedure which enlarges the eye horizontally, is performed at the inner corner of the eye, whereas lateral canthoplasty enlarges the outer edge of the eye. In particular, if the slant of the palpebral fissure is raised and the horizontal dimension of the palpebral fissure is short, adjusting the slant of the palpebral fissure through lateral canthoplasty can achieve an enlargement of eye width and smoother features. Depending on the patient's condition, even better results can be achieved if this procedure is performed in conjunction with other procedures, such as double eyelidplasty, epicanthoplasty, eye roll formation surgery, fat graft, and facial bone contouring surgery. In this paper, the authors will introduce in detail their surgical method for a cosmetic lateral canthoplasty that lengthens the lateral canthal angle and corrects the outer tail of the eyes, in order to ease the unfavorable impression. PMID:27462564

  15. Genetics Home Reference: amyotrophic lateral sclerosis

    MedlinePlus

    ... amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014 Jul 1;23(13): ... Accessibility FOIA Viewers & Players U.S. Department of Health & Human Services National Institutes of Health National Library of ...

  16. The National Report--Five Years Later.

    ERIC Educational Resources Information Center

    Stewart, Bob R.; And Others

    1993-01-01

    Six theme articles assess the impact five years later of the National Academy of Sciences report, "Understanding Agriculture." Topics discussed include strategic planning, agricultural education's mission, teacher education, policy research needs, and agricultural literacy. (SK)

  17. Individualized optimal surgical extent of the lateral neck in papillary thyroid cancer with lateral cervical metastasis.

    PubMed

    Park, Jae-Yong; Koo, Bon Seok

    2014-06-01

    Despite an excellent prognosis, cervical lymph node (LN) metastases are common in patients with papillary thyroid cancer (PTC). The presence of metastasis is associated with an increased risk of locoregional recurrence, which significantly impairs quality of life and may decrease survival. Therefore, it has been an important determinant of the extent of lateral LN dissection in the initial treatment of PTC patients with lateral cervical metastasis. However, the optimal extent of therapeutic lateral neck dissection (ND) remains controversial. Optimizing the surgical extent of LN dissection is fundamental for balancing the surgical morbidity and oncological benefits of ND in PTC patients with lateral neck metastasis. We reviewed the currently available literature regarding the optimal extent of lateral LN dissection in PTC patients with lateral neck metastasis. Even in cases with suspicion of metastatic LN at the single lateral level or isolated metastatic lateral LN, the application of ND including all sublevels from IIa and IIb to Va and Vb may be overtreatment, due to the surgical morbidity. When there is no suspicion of LN metastasis at levels II and V, or when multilevel aggressive neck metastasis is not found, sublevel IIb and Va dissection may not be necessary in PTC patients with lateral neck metastasis. Thus consideration of the individualized optimal surgical extent of lateral ND is important when treating PTC patients with lateral cervical metastasis.

  18. Brain and behavioral lateralization in invertebrates

    PubMed Central

    Frasnelli, Elisa

    2013-01-01

    Traditionally, only humans were thought to exhibit brain and behavioral asymmetries, but several studies have revealed that most vertebrates are also lateralized. Recently, evidence of left–right asymmetries in invertebrates has begun to emerge, suggesting that lateralization of the nervous system may be a feature of simpler brains as well as more complex ones. Here I present some examples in invertebrates of sensory and motor asymmetries, as well as asymmetries in the nervous system. I illustrate two cases where an asymmetric brain is crucial for the development of some cognitive abilities. The first case is the nematode Caenorhabditis elegans, which has asymmetric odor sensory neurons and taste perception neurons. In this worm left/right asymmetries are responsible for the sensing of a substantial number of salt ions, and lateralized responses to salt allow the worm to discriminate between distinct salt ions. The second case is the fruit fly Drosophila melanogaster, where the presence of asymmetry in a particular structure of the brain is important in the formation or retrieval of long-term memory. Moreover, I distinguish two distinct patterns of lateralization that occur in both vertebrates and invertebrates: individual-level and population-level lateralization. Theoretical models on the evolution of lateralization suggest that the alignment of lateralization at the population level may have evolved as an evolutionary stable strategy in which individually asymmetrical organisms must coordinate their behavior with that of other asymmetrical organisms. This implies that lateralization at the population-level is more likely to have evolved in social rather than in solitary species. I evaluate this new hypothesis with a specific focus on insects showing different level of sociality. In particular, I present a series of studies on antennal asymmetries in honeybees and other related species of bees, showing how insects may be extremely useful to test the

  19. Management of horizontally impacted dilacerated lateral incisor

    PubMed Central

    Katta, Anil Kumar; Peddu, Revathi; Vannala, Venkataramana; Dasari, Vaishnavi

    2015-01-01

    Impaction of maxillary lateral incisor with odontome and retained deciduous tooth is not often seen in regular dental practice. Impaction of anterior teeth cause generalized spacing which affects the esthetics of the face. Here we report a case of an 18-year-old patient with horizontally impacted dilacerated lateral incisor, which was bought into occlusion with the help of orthodontic tooth movement within a span of 18 months. PMID:26538954

  20. Lateral shear interferometry with holo shear lens

    NASA Astrophysics Data System (ADS)

    Joenathan, C.; Mohanty, R. K.; Sirohi, R. S.

    1984-12-01

    A simple method for obtaining lateral shear using holo shear lenses (HSL) has been discussed. This simple device which produces lateral shears in the orthogonal directions has been used for lens testing. The holo shear lens is placed at or near the focus of the lens to be tested. It has also been shown that HSL can be used in speckle shear interferometry as it performs both the functions of shearing and imaging.

  1. Laterality enhances cognition in Australian parrots.

    PubMed

    Magat, Maria; Brown, Culum

    2009-12-01

    Cerebral lateralization refers to the division of information processing in either hemisphere of the brain and is a ubiquitous trait among vertebrates and invertebrates. Given its widespread occurrence, it is likely that cerebral lateralization confers a fitness advantage. It has been hypothesized that this advantage takes the form of enhanced cognitive function, potentially via a dual processing mechanism whereby each hemisphere can be used to process specific types of information without contralateral interference. Here, we examined the influence of lateralization on problem solving by Australian parrots. The first task, a pebble-seed discrimination test, was designed for small parrot species that feed predominately on small seeds, which do not require any significant manipulation with the foot prior to ingestion. The second task, a string-pull problem, was designed for larger bodied species that regularly use their feet to manipulate food objects. In both cases, strongly lateralized individuals (those showing significant foot and eye biases) outperformed less strongly lateralized individuals, and this relationship was substantially stronger in the more demanding task. These results suggest that cerebral lateralization is a ubiquitous trait among Australian parrots and conveys a significant foraging advantage. Our results provide strong support for the enhanced cognitive function hypothesis.

  2. Possible evolutionary origins of cognitive brain lateralization.

    PubMed

    Vallortigara, G; Rogers, L J; Bisazza, A

    1999-08-01

    Despite the substantial literature on the functional architecture of the asymmetries of the human brain, which has been accumulating for more than 130 years since Dax and Broca's early reports, the biological foundations of cerebral asymmetries are still poorly understood. Recent advances in comparative cognitive neurosciences have made available new animal models that have started to provide unexpected insights into the evolutionary origins and neuronal mechanisms of cerebral asymmetries. Animal model-systems, particularly those provided by the avian brain, highlight the interrelations of genetic, hormonal and environmental events to produce neural and behavioural asymmetries. Novel evidences showing that functional and structural lateralization of the brain is widespread among vertebrates (including fish, reptiles and amphibians) have accumulated rapidly. Perceptual asymmetries, in particular, seem to be ubiquitous in everyday behaviour of most species of animals with laterally placed eyes; in organisms with wider binocular overlap (e.g., amphibians), they appear to be retained for initial detection of stimuli in the extreme lateral fields. We speculate that adjustment of head position and eye movements may play a similar role in mammals with frontal vision as does the choice for right or left lateral visual fields in animals with laterally placed eyes. A first attempt to trace back the origins of brain asymmetry to early vertebrates is presented, based on the hypothesis that functional incompatibility between the logical demands associated with very basic cognitive functions is central to the phenomenon of cerebral lateralization. PMID:10525173

  3. Listeners' impressions of speakers with lateral lisps.

    PubMed

    Silverman, E M

    1976-11-01

    This paper reports research conducted to determine whether the lateral lisp is a speech defect. The specific purpose of this research was to determine whether the lateral lisp calls adverse attention to the speaker. Two groups of broadcast communication students rates the concept "The Person Speaking" on a 49-scale semantic differential. One group performed the task after listening to a tape recording of a young woman reading contextual material with a simulated lateral lisp. The other group performed the task after listening to a recording of the same woman reading the material in a normal manner. Analyses of the scale values computed for the two conditions indicated that the lateral lisp called adverse attention to the speaker. A systematic replication was undertaken to assess the generality of this finding. The procedures of the original investigation were followed except that business administration students served as judges. The results replicated those of the original investigation. These data indicate that the lateral lisp is probably a speech defect and suggest that the practice of eliminating school speech services for children whose only speech difference is a lateral lisp should be reconsidered. PMID:994486

  4. Lateral restraint assembly for reactor core

    DOEpatents

    Gorholt, Wilhelm; Luci, Raymond K.

    1986-01-01

    A restraint assembly for use in restraining lateral movement of a reactor core relative to a reactor vessel wherein a plurality of restraint assemblies are interposed between the reactor core and the reactor vessel in circumferentially spaced relation about the core. Each lateral restraint assembly includes a face plate urged against the outer periphery of the core by a plurality of compression springs which enable radial preloading of outer reflector blocks about the core and resist low-level lateral motion of the core. A fixed radial key member cooperates with each face plate in a manner enabling vertical movement of the face plate relative to the key member but restraining movement of the face plate transverse to the key member in a plane transverse to the center axis of the core. In this manner, the key members which have their axes transverse to or subtending acute angles with the direction of a high energy force tending to move the core laterally relative to the reactor vessel restrain such lateral movement.

  5. Lateralization of cognitive processes in the brain.

    PubMed

    Hugdahl, K

    2000-12-01

    The lateralization of cognitive processes in the brain is discussed. The traditional view of a language-visuo/spatial dichotomy of function between the hemispheres has been replaced by more subtle distinctions. The use of magnetic resonance imaging (MRI) to study brain morphology has resulted in a renewed focus on the relationship between structural and functional asymmetry. Focus has been on the role played by the planum temporale area in the posterior part of the superior temporal gyrus for language asymmetry, and the possible significance of the larger left planum. The dichotic listening technique is used to illustrate the difference between bottom-up, or stimulus-driven laterality versus top-down, or instruction-driven laterality. It is suggested that the hemispheric dominance observed at any time is the sum result of the dynamic interaction between bottom-up and top-down processing tendencies. Stimulus-driven laterality dominance is always monitored and modulated through top-down cognitive processes, like shifting of attention and changes in arousal. A model of top-down modulation of bottom-up laterality is presented with special reference to the understanding of psychiatric disorders. PMID:11194413

  6. Predicting language lateralization from gray matter

    PubMed Central

    Josse, Goulven; Kherif, Ferath; Flandin, Guillaume; Seghier, Mohamed L; Price, Cathy J

    2009-01-01

    It has long been predicted that the degree to which language is lateralized to the left or right hemisphere might be reflected in the underlying brain anatomy. We investigated this relationship on a voxel by voxel basis across the whole brain using structural and functional MRI images from 86 healthy participants. Structural images were converted to gray matter probability images and language activation was assessed during naming and semantic decision. All images were spatially normalized to the same symmetrical template and lateralization images were generated by subtracting right from left hemisphere signal at each voxel. We show that the degree to which language was left or right lateralized was positively correlated with the degree to which gray matter density was lateralized. Post-hoc analyses revealed a general relationship between gray matter probability and BOLD signal. This is the first demonstration that structural brain scans can be used to predict language lateralization on a voxel by voxel basis in the normal healthy brain. PMID:19864564

  7. Language lateralization shifts with learning by adults.

    PubMed

    Plante, Elena; Almryde, Kyle; Patterson, Dianne K; Vance, Christopher J; Asbjørnsen, Arve E

    2015-05-01

    For the majority of the population, language is a left-hemisphere lateralized function. During childhood, a pattern of increasing left lateralization for language has been described in brain imaging studies, suggesting that this trait develops. This development could reflect change due to brain maturation or change due to skill acquisition, given that children acquire and refine language skills as they mature. We test the possibility that skill acquisition, independent of age-associated maturation can result in shifts in language lateralization in classic language cortex. We imaged adults exposed to an unfamiliar language during three successive fMRI scans. Participants were then asked to identify specific words embedded in Norwegian sentences. Exposure to these sentences, relative to complex tones, resulted in consistent activation in the left and right superior temporal gyrus. Activation in this region became increasingly left-lateralized with repeated exposure to the unfamiliar language. These results demonstrate that shifts in lateralization can be produced in the short term within a learning context, independent of maturation.

  8. Lateral stability in sideward cutting movements.

    PubMed

    Stacoff, A; Steger, J; Stüssi, E; Reinschmidt, C

    1996-03-01

    Sideward cutting movements occur frequently in sports activities, such as basketball, soccer, and tennis. These activities show a high incidence of injuries to the lateral aspect of the ankle. Consequently, the lateral stability of sport shoes seems important. The purpose of this study was to show the effect of different shoe sole properties (hardness, thickness, torsional stiffness) and designs on the lateral stability during sideward cutting movements. A film analysis was conducted including 12 subjects performing a cutting movement barefoot and with five different pairs of shoes each filmed in the frontal plane. A standard film analysis was conducted; for the statistical analysis, various parameters such as the range of motion in inversion and the angular velocity of the rearfoot were used. The results showed a large difference between the barefoot and shod conditions with respect to the lateral stability. Two shoes performed significantly better (P < 0.05) than the others with a decreased inversion movement and less slipping inside the shoe. The two shoes differed mainly in the shoe sole design (hollow inner core) and the upper (high-cut). It is concluded that lateral stability may be improved by altering the properties and design of the shoe sole as well as the upper.

  9. LOB Domain Proteins: Beyond Lateral Organ Boundaries.

    PubMed

    Xu, Changzheng; Luo, Feng; Hochholdinger, Frank

    2016-02-01

    LATERAL ORGAN BOUNDARIES DOMAIN (LBD) proteins defined by a conserved LATERAL ORGAN BOUNDARIES (LOB) domain are key regulators of plant organ development. Recent studies have expanded their functional diversity beyond the definition of lateral organ boundaries to pollen development, plant regeneration, photomorphogenesis, pathogen response, and specific developmental functions in non-model plants, such as poplar and legumes. The identification of a range of upstream regulators, protein partners, and downstream targets of LBD family members has unraveled the molecular networks of LBD-dependent processes. Moreover, it has been demonstrated that LBD proteins have essential roles in integrating developmental changes in response to phytohormone signaling or environmental cues. As we discuss here, these novel discoveries of LBD functions and their molecular contexts promote a better understanding of this plant-specific transcription factor family. PMID:26616195

  10. The Lateral Instability of Deep Rectangular Beams

    NASA Technical Reports Server (NTRS)

    Dumont, C; Hill, H N

    1937-01-01

    Experimental and analytical studies were made of solid and hollow deep rectangular beams to study their lateral instability under various conditions of loading and restraint. The tests were made on bars and tubes of 17ST aluminum alloy. Failure by lateral buckling occurred only in tests on the solid beams. It was found that, within the elastic range, the test results were in agreement with the classical theory for the lateral buckling of deep beams as given by Prandtl, Mitchell, and Timoshenko. The tests were extended to the inelastic range, where it was found that the substitution for Young's modulus of an average modulus of elasticity derived from the stress-strain curve made it possible to predict instability at high stresses.

  11. Stress and laterality - The comparative perspective.

    PubMed

    Ocklenburg, Sebastian; Korte, S Mechiel; Peterburs, Jutta; Wolf, Oliver T; Güntürkün, Onur

    2016-10-01

    Functional hemispheric asymmetries can vary over time and steroid hormones have been shown to be one of the factors that can modulate them. Research into this matter has mainly focused on sex steroid hormones (androgens, estrogens and progestogens), although there is increasing evidence that glucocorticoids which are related to the body's response to stress (e.g. cortisol or corticosterone) might also modulate functional hemispheric asymmetries. Here, we review studies in humans and non-human model species investigating the relation of stress and laterality. Results indicate a dual relationship of the two parameters. Both acute and chronic stress can affect different forms of lateralization in the human brain, often (but not always) resulting in greater involvement of the right hemisphere. Moreover, lateralization as a form of functional brain architecture can also represent a protective factor against adverse effects of stress. PMID:27321757

  12. Mitek Suspension of the Lateral Nasal Wall.

    PubMed

    White, James R; Hamilton, Grant S

    2016-02-01

    The nasal valve has long been described as the anatomical boundary most likely to inhibit nasal airflow and lead to subsequent nasal obstruction. Although many procedures can address this area to improve the nasal airway, for over 20 years, suture lateralization of the external nasal valve has been described as a minimally invasive technique that can improve nasal breathing. We report our modification of the standard technique in which we lateralize the placement of the bone-anchored suture and incorporate Gore-Tex within the nasal vestibular incision to prevent tissue migration. PMID:26862966

  13. [Lateral chest X-rays. Radiographic anatomy].

    PubMed

    García Villafañe, C; Pedrosa, C S

    2014-01-01

    Lateral chest views constitute an essential part of chest X-ray examinations, so it is fundamental to know the anatomy on these images and to be able to detect the variations manifested on these images in different diseases. The aim of this article is to review the normal anatomy and main normal variants seen on lateral chest views. For teaching purposes, we divide the thorax into different spaces and analyze each in an orderly way, especially emphasizing the anatomic details that are most helpful for locating lesions that have already been detected in the posteroanterior view or for detecting lesions that can be missed in the posteroanterior view.

  14. Amyotrophic Lateral Sclerosis: A Historical Perspective.

    PubMed

    Katz, Jonathan S; Dimachkie, Mazen M; Barohn, Richard J

    2015-11-01

    This article looks back in time to see where the foundational basis for the understanding of amyotrophic lateral sclerosis originated. This foundation was created primarily in France by Jean-Martin Charcot and his fellow countrymen and disciples, along with key contributions from early clinicians in England and Germany. The early work on amyotrophic lateral sclerosis provides a useful foundation for today's clinicians with respect to tying together genetic and biologic aspects of the disorder that have been discovered over the past few decades.

  15. Parameter Estimation of Lateral Spacecraft Fuel Slosh

    NASA Technical Reports Server (NTRS)

    Sudermann, James E.; Schlee, Keith L.

    2008-01-01

    Predicting the effect of fuel slosh on the attitude control system of a spacecraft or launch vehicle is a very important and challenging task. Whether the spacecraft is spinning or moving laterally, the dynamic effect of the fuel slosh helps determine whether the spacecraft will remain on its intended trajectory. Three categories of slosh can be caused by launch vehicle or spacecraft maneuvers when the fuel is in the presence of an acceleration field. These are bulk-fluid motion, subsurface wave motion (currents), and free-surface slosh. Each of these slosh types has a periodic component defined by either a spinning or a lateral motion. For spinning spacecraft, all three types of slosh can greatly affect stability. Bulk-fluid motion and free-surface slosh can affect the lateral-slosh characteristics. For either condition, an unpredicted coupled resonance between the spacecraft and its onboard fuel could threaten a mission. This ongoing research effort seeks to improve the accuracy and efficiency of modeling techniques used to predict these types of fluid motions for lateral motion. Particular efforts focus on analyzing the effects of viscoelastic diaphragms on slosh dynamics.

  16. Anterolateral Meniscofemoral Ligament of the Lateral Meniscus

    PubMed Central

    Kim, Young-Mo; Yeon, Kyu-Woong; Lee, Ki-Young

    2016-01-01

    Anatomical variations of the meniscus are a common anomaly that knee surgeons frequently encounter. However, anomalies of the anterior horn of the lateral meniscus (AHLM) are extremely rare. In this report, we present a newly discovered anomaly of the AHML: an anterolateral meniscofemoral ligament is described with clinical features and radiographic and arthroscopic findings.

  17. Lateral drug diffusion in human nails.

    PubMed

    Palliyil, Biji B; Li, Cong; Owaisat, Suzan; Lebo, David B

    2014-12-01

    The main objective of the current work is to demonstrate the process of passive lateral diffusion in the human nail plate and its effect on the passive transungual permeation of antifungal drug ciclopirox olamine (CPO). A water soluble dye, methyl red sodium salt (MR) was used to visualize the process of lateral diffusion using a novel suspended nail experiment. The decline in concentration of CPO correlates with that of concentration of MR from the proximal to the distal end of the nail in suspended nail study. Three toenails each were trimmed to 5 mm × 5 mm (25 mm(2)), 7 mm × 7 mm (49 mm(2)), and 9 mm × 9 mm (81 mm(2)) to study the extent and effect of lateral diffusion of the CPO on its in vitro transungual permeation. The permeation flux of CPO decreased as the surface area of the toenail increased. There was a positive correlation between the concentrations of CPO and MR in the area of application and in the peripheral area of the toenails of the three surface areas, confirming the findings in the suspended nail experiment. Profound lateral diffusion of CPO was demonstrated and shown to reduce the in vitro passive transungual drug permeation and prolong the lag-time in human toenails. The study data implies that during passive in vitro transungual permeation experiments, the peripheral nail around the area of drug application has to be kept to a minimum, in order to get reliable data which mimics the in vivo situation. PMID:24970585

  18. Quantifying lateral tissue heterogeneities in hadron therapy

    SciTech Connect

    Pflugfelder, D.; Wilkens, J. J.; Szymanowski, H.; Oelfke, U.

    2007-04-15

    In radiotherapy with scanned particle beams, tissue heterogeneities lateral to the beam direction are problematic in two ways: they pose a challenge to dose calculation algorithms, and they lead to a high sensitivity to setup errors. In order to quantify and avoid these problems, a heterogeneity number H{sub i} as a method to quantify lateral tissue heterogeneities of single beam spot i is introduced. To evaluate this new concept, two kinds of potential errors were investigated for single beam spots: First, the dose calculation error has been obtained by comparing the dose distribution computed by a simple pencil beam algorithm to more accurate Monte Carlo simulations. The resulting error is clearly correlated with H{sub i}. Second, the analysis of the sensitivity to setup errors of single beam spots also showed a dependence on H{sub i}. From this data it is concluded that H{sub i} can be used as a criterion to assess the risks of a compromised delivered dose due to lateral tissue heterogeneities. Furthermore, a method how to incorporate this information into the inverse planning process for intensity modulated proton therapy is presented. By suppressing beam spots with a high value of H{sub i}, the unfavorable impact of lateral tissue heterogeneities can be reduced, leading to treatment plans which are more robust to dose calculation errors of the pencil beam algorithm. Additional possibilities to use the information of H{sub i} are outlined in the discussion.

  19. One hand clapping: lateralization of motor control

    PubMed Central

    Welniarz, Quentin; Dusart, Isabelle; Gallea, Cécile; Roze, Emmanuel

    2015-01-01

    Lateralization of motor control refers to the ability to produce pure unilateral or asymmetric movements. It is required for a variety of coordinated activities, including skilled bimanual tasks and locomotion. Here we discuss the neuroanatomical substrates and pathophysiological underpinnings of lateralized motor outputs. Significant breakthroughs have been made in the past few years by studying the two known conditions characterized by the inability to properly produce unilateral or asymmetric movements, namely human patients with congenital “mirror movements” and model rodents with a “hopping gait”. Whereas mirror movements are associated with altered interhemispheric connectivity and abnormal corticospinal projections, abnormal spinal cord interneurons trajectory is responsible for the “hopping gait”. Proper commissural axon guidance is a critical requirement for these mechanisms. Interestingly, the analysis of these two conditions reveals that the production of asymmetric movements involves similar anatomical and functional requirements but in two different structures: (i) lateralized activation of the brain or spinal cord through contralateral silencing by cross-midline inhibition; and (ii) unilateral transmission of this activation, resulting in lateralized motor output. PMID:26082690

  20. Lateral Biases in Assumptions of Lighting Position

    ERIC Educational Resources Information Center

    Elias, Lorin J.; Robinson, Brent M.

    2005-01-01

    People presume that the light source in pictures comes from above, and there is some evidence that this phenomenon also demonstrates lateral biases. When investigators present multiple ambiguous stimuli or visually complex objects, people assume that the source of light is from above, and to the left. However, when single relatively simple stimuli…

  1. Profiling 1366 Technologies: One Year Later

    ScienceCinema

    Van Mierlo, Frank; Sachs, Ely

    2016-07-12

    Last January, we took a look at how ARPA-E performer, 1366 Technologies is working to dramatically reduce the cost of solar energy. A year later, we revisited their headquarters in Lexington, MA to see the progress they've made.

  2. [Upper lateral incisor with 2 canals].

    PubMed

    Fabra Campos, H

    1991-01-01

    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum.

  3. Profiling 1366 Technologies: One Year Later

    SciTech Connect

    Van Mierlo, Frank; Sachs, Ely

    2011-01-01

    Last January, we took a look at how ARPA-E performer, 1366 Technologies is working to dramatically reduce the cost of solar energy. A year later, we revisited their headquarters in Lexington, MA to see the progress they've made.

  4. 33 CFR 62.25 - Lateral marks.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Lateral marks define the port and starboard sides of a route to be followed. They may be either beacons or.... Beacons have green square daymarks, while buoys are green can or pillar buoys. (2) Starboard hand marks indicate the right side of channels when proceeding in the Conventional Direction of Buoyage. Beacons...

  5. 33 CFR 62.25 - Lateral marks.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Lateral marks define the port and starboard sides of a route to be followed. They may be either beacons or.... Beacons have green square daymarks, while buoys are green can or pillar buoys. (2) Starboard hand marks indicate the right side of channels when proceeding in the Conventional Direction of Buoyage. Beacons...

  6. 33 CFR 62.25 - Lateral marks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Lateral marks define the port and starboard sides of a route to be followed. They may be either beacons or.... Beacons have green square daymarks, while buoys are green can or pillar buoys. (2) Starboard hand marks indicate the right side of channels when proceeding in the Conventional Direction of Buoyage. Beacons...

  7. 33 CFR 62.25 - Lateral marks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Lateral marks define the port and starboard sides of a route to be followed. They may be either beacons or.... Beacons have green square daymarks, while buoys are green can or pillar buoys. (2) Starboard hand marks indicate the right side of channels when proceeding in the Conventional Direction of Buoyage. Beacons...

  8. 33 CFR 62.25 - Lateral marks.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Lateral marks define the port and starboard sides of a route to be followed. They may be either beacons or.... Beacons have green square daymarks, while buoys are green can or pillar buoys. (2) Starboard hand marks indicate the right side of channels when proceeding in the Conventional Direction of Buoyage. Beacons...

  9. Anterolateral Meniscofemoral Ligament of the Lateral Meniscus

    PubMed Central

    Kim, Young-Mo; Yeon, Kyu-Woong; Lee, Ki-Young

    2016-01-01

    Anatomical variations of the meniscus are a common anomaly that knee surgeons frequently encounter. However, anomalies of the anterior horn of the lateral meniscus (AHLM) are extremely rare. In this report, we present a newly discovered anomaly of the AHML: an anterolateral meniscofemoral ligament is described with clinical features and radiographic and arthroscopic findings. PMID:27595080

  10. The Columbine Tragedy Ten Years Later

    ERIC Educational Resources Information Center

    Hammond, Jane

    2009-01-01

    Some tragedies are so emblazoned in people's minds that years later they can recall where they were when they first heard the news. The assassinations of John F. Kennedy and Martin Luther King Jr., the Challenger explosion, and the Sept. 11 terrorist attacks are among these events. So also is the Columbine High School tragedy of April 20, 1999.…

  11. Lateral drug diffusion in human nails.

    PubMed

    Palliyil, Biji B; Li, Cong; Owaisat, Suzan; Lebo, David B

    2014-12-01

    The main objective of the current work is to demonstrate the process of passive lateral diffusion in the human nail plate and its effect on the passive transungual permeation of antifungal drug ciclopirox olamine (CPO). A water soluble dye, methyl red sodium salt (MR) was used to visualize the process of lateral diffusion using a novel suspended nail experiment. The decline in concentration of CPO correlates with that of concentration of MR from the proximal to the distal end of the nail in suspended nail study. Three toenails each were trimmed to 5 mm × 5 mm (25 mm(2)), 7 mm × 7 mm (49 mm(2)), and 9 mm × 9 mm (81 mm(2)) to study the extent and effect of lateral diffusion of the CPO on its in vitro transungual permeation. The permeation flux of CPO decreased as the surface area of the toenail increased. There was a positive correlation between the concentrations of CPO and MR in the area of application and in the peripheral area of the toenails of the three surface areas, confirming the findings in the suspended nail experiment. Profound lateral diffusion of CPO was demonstrated and shown to reduce the in vitro passive transungual drug permeation and prolong the lag-time in human toenails. The study data implies that during passive in vitro transungual permeation experiments, the peripheral nail around the area of drug application has to be kept to a minimum, in order to get reliable data which mimics the in vivo situation.

  12. Religious Attendance and Loneliness in Later Life

    ERIC Educational Resources Information Center

    Rote, Sunshine; Hill, Terrence D.; Ellison, Christopher G.

    2013-01-01

    Purpose of the Study: Studies show that loneliness is a major risk factor for health issues in later life. Although research suggests that religious involvement can protect against loneliness, explanations for this general pattern are underdeveloped and undertested. In this paper, we propose and test a theoretical model, which suggests that social…

  13. [Upper lateral incisor with 2 canals].

    PubMed

    Fabra Campos, H

    1991-01-01

    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum. PMID:1659854

  14. Control augmentation for lateral control wheel steering

    NASA Technical Reports Server (NTRS)

    Foulkes, R. H., Jr.

    1981-01-01

    Flight control system design for lateral control wheel steering is discussed. Two alternate designs are presented. The first design is a roll-rate command, bank-angle hold system with a wings-level track-hold submode. The second is a curved-track-hold system. Design details and real-time flight simulator results are included.

  15. MEPHISTO spectromicroscope reaches 20 nm lateral resolution

    NASA Astrophysics Data System (ADS)

    De Stasio, Gelsomina; Perfetti, Luca; Gilbert, B.; Fauchoux, O.; Capozi, M.; Perfetti, P.; Margaritondo, G.; Tonner, B. P.

    1999-03-01

    The recently described tests of the synchrotron imaging photoelectron spectromicroscope MEPHISTO (Microscope à Emission de PHotoélectrons par Illumination Synchrotronique de Type Onduleur) were complemented by further resolution improvements and tests, which brought the lateral resolution down to 20 nm. Images and line plot profiles demonstrate such performance.

  16. Eccentric Strengthening for Chronic Lateral Epicondylosis

    PubMed Central

    Wen, Dennis Y.; Schultz, Brian J.; Schaal, Bob; Graham, Scott T.; Kim, Byung Sung

    2011-01-01

    Background: Effective treatments for chronic lateral epicondylosis have not been studied adequately. Eccentric overload exercises have been used with success for other chronic tendinopathy, mainly Achilles and patellar. Hypothesis/Purpose: To compare a wrist extensor eccentric strengthening exercise program with a wrist extensor stretching/modality program for the treatment of chronic lateral epicondylosis. The authors hypothesized that the eccentric strengthening program would produce more favorable results than a stretching/modality program. Study Design: Prospective randomized controlled trial. Methods: Twenty-eight adults with lateral epicondylosis of greater than 4 weeks’ duration were randomized to an eccentric strengthening group or a stretching group. Exercises were taught by a physical therapist, and participants performed most of the exercises on their own at home. Pain scores with visual analog scale from 0 to 100 were obtained at baseline and then at 4, 8, 12, 16, and 20 weeks after the start of the exercise program. Results: Both groups improved their pain scores from baseline to the 4-week time point, followed by nonsignificant further decreases in pain scores thereafter. No statistically significant differences were found between the eccentric strengthening group and stretching groups at any follow-up time point. Conclusions: Despite previous reports documenting favorable results with eccentric exercises for other tendinopathy, the authors were unable to show any statistical advantage to eccentric exercises for lateral epicondylosis during these periods compared with local modalities and stretching exercises. PMID:23016049

  17. Lateralized Temporal Order Judgement in Dyslexia

    ERIC Educational Resources Information Center

    Liddle, Elizabeth B.; Jackson, Georgina M.; Rorden, Chris; Jackson, Stephen R.

    2009-01-01

    Temporal and spatial attentional deficits in dyslexia were investigated using a lateralized visual temporal order judgment (TOJ) paradigm that allowed both sensitivity to temporal order and spatial attentional bias to be measured. Findings indicate that adult participants with a positive screen for dyslexia were significantly less sensitive to the…

  18. Preparing Future Faculty: Ten Years Later

    ERIC Educational Resources Information Center

    Murphy, Sean P.; Aiossa, Elizabeth; Winter, Mary Mugica

    2010-01-01

    When Sean Murphy designed the Graduate Student Internship Program at the College of Lake County (CLC), his 2001 TETYC article about the then two-year-old program detailed his programmatic response to the job market. Ten years later, the CLC-DePaul University partnership remains the strongest of the original dozen cross-sector relationships CLC…

  19. Anterolateral Meniscofemoral Ligament of the Lateral Meniscus.

    PubMed

    Kim, Young-Mo; Joo, Yong-Bum; Yeon, Kyu-Woong; Lee, Ki-Young

    2016-09-01

    Anatomical variations of the meniscus are a common anomaly that knee surgeons frequently encounter. However, anomalies of the anterior horn of the lateral meniscus (AHLM) are extremely rare. In this report, we present a newly discovered anomaly of the AHML: an anterolateral meniscofemoral ligament is described with clinical features and radiographic and arthroscopic findings.

  20. Depression in Later Life: Recognition and Treatment.

    ERIC Educational Resources Information Center

    Schmall, Vicki L.; And Others

    This guide is designed to help readers understand depression and factors related to its onset in later life; recognize signs of depression and potential suicide; and know actions they can take if they suspect an older family member or friend may be depressed or contemplating suicide. Following a brief introduction, a chapter on depression…

  1. Lateral Hip Pain in an Athletic Population

    PubMed Central

    Grumet, Robert C.; Frank, Rachel M.; Slabaugh, Mark A.; Virkus, Walter W.; Bush-Joseph, Charles A.; Nho, Shane J.

    2010-01-01

    Context: Historically, the term greater trochanteric pain syndrome has been used to describe a spectrum of conditions that cause lateral-sided hip pain, including greater trochanteric bursitis, snapping iliotibial band, and/or strains or tendinopathy of the abductor mechanism. Diagnosis of these conditions may be difficult because clinical presentations are variable and sometimes inconclusive. Especially difficult is differentiating intrinsic pain from pain referred to the greater trochanteric region. The purposes of this article are to review the relevant anatomy and pathophysiology of the lateral hip. Evidence Acquisition: Data were collected through a thorough review of the literature conducted through a MEDLINE search of all relevant papers between 1980 and January 2010. Results: Recent advances in imaging and an improved understanding of pathomechanics have helped to guide the evaluation, diagnosis, and appropriate treatment for patients presenting with lateral hip pain. Conclusion: Various diagnostic tools and treatment modalities can be used to effectively manage the athletic patient presenting with lateral hip pain. PMID:23015937

  2. Lateral canthal repositioning in syndromic, antimongoloid slant

    PubMed Central

    Balaji, S. M.

    2016-01-01

    Introduction: To report a single center's experience in correcting antimongoloid slant in Asian eyes using a minimally invasive approach. Methods: Retrospective analysis of patients undergoing correction for antimongoloid slant at author's center, from 2007 to 2013 formed the study group. Concomitant surgical procedures were recorded. Pre- and post-operative photographs at the longest follow-up visit were analyzed and graded for functional and cosmetic outcomes. Results: A total of 38 patients (76 eyelids) underwent successful correction to correct eyelid malposition. All patients’ eyelids underwent exclusive lateral canthoplasty through a small incision in the upper eyelid crease and re-suspension technique, and 6 of them underwent bilateral slant correction simultaneously with additional cosmetic or corrective surgeries including hemifacial microsomia and Crouzon's syndrome. Of the 38 patients, 25 were females and 13 were males. The age of the population ranged from 7 to 48 years with a mean age of 27 years. Few instances of transient postoperative chemosis lasting up to 2 weeks and minor infections were reported. All cases showed improvement in eyelid position (as assessed clinically and on photographs), 2 pediatric cases required reoperation in the following 2 years for the recurrent lower eyelid malposition and/or lateral canthal deformity owing to deviated basal bone growth. Discussion: Lateral canthoplasty with resuspension technique can effectively address antimongoloid slant for an esthetically desirable lateral canthus. PMID:27563607

  3. Active Children: Healthy Now And Later

    ERIC Educational Resources Information Center

    Campbell, Linley; Musumeci, Josephine

    2005-01-01

    Current research is revealing that physical activity can protect against a range of lifestyle diseases and illnesses. Consequently, early childhood practitioners and parents need to adopt guidelines and practices which encourage children of all ages to be physically active. In "Active children: Healthy Now and Later," authors Linley Campbell and…

  4. Simulation of lateral flow with SWAT

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Calibration of the SWAT model for the Goodwater Creek Experimental Watershed (GCEW) showed that percolation through the restrictive claypan layer, lateral flow above that layer, and redistribution of excess moisture up to the ground surface were not correctly simulated. In addition, surface runoff a...

  5. Laterality and Directional Preferences in Preschool Children.

    ERIC Educational Resources Information Center

    Tan, Lesley E.

    1982-01-01

    Directional preference for horizontal hand movements was investigated in 49 right- and 49 left-handed four-year-olds using three drawing tests. Directionality for more complex perceptual-motor tasks has a different basis than directionality for simple tasks; such directionality is established at a later age but only for the right hand. (Author/CM)

  6. Cerebral Lateralization and Its Effect on Drawing.

    ERIC Educational Resources Information Center

    Thomas, Yvonne A.; Thomas, Stephen B.

    1983-01-01

    Discusses the importance of both sides of the brain for the development of drawing skills but notes that the left brain can inhibit the action of the right brain. Provides a discussion of cerebral lateralization and child development. Suggests five drawing exercises to help develop hemispheric cooperation. (SB)

  7. Lateral ankle sprains and instability problems.

    PubMed

    Liu, S H; Jason, W J

    1994-10-01

    The lateral ankle complex is the most frequently injured single structure in athletes, consisting of 38% to 45% of all injuries. One-sixth of all sports injury loss time is from ankle sprains. In North America, ankle inversion sprains are considered "de rigeur" for basketball participation.

  8. Lateral organic photodetectors for imaging applications

    NASA Astrophysics Data System (ADS)

    Shafique, Umar; Karim, Karim S.

    2011-03-01

    Organic semiconductor detectors have always been in active research interest of researchers due to its low fabrication cost. Vertical organic detectors have been studied in the past but not much of the works have been done on lateral organic detectors. The lateral design has an advantage over the vertical design that it is easy to fabricate and can be easily integrated with the backplane TFT imager circuit. Integrating an organic photodetectors with TFT imager can improve the over all sensitivity of the imager. However the lateral design limits the fill-factor. Here in our work we propose a new bilayered lateral organic photodetectors with Copper-Phthalocyanine (CUPC) as top and Perylene- Tetracarboxylic Bis- Benzimidazole (PTCBI) as the bottom layer organic material. The bottom organic semiconductor layer work as both, charge transport layer and photon absorption layer. The top and bottom layer provides and heterojunction a potential gradient enough to separate the photo generated excitons in to electrons and holes. The incident photons are absorbed in the two layers active layers giving an exciton. These excitons see a potential barrier at the CUPC-PTCBI heterojunction and separated into holes and electrons. The separated electrons are directed by the external applied electric field and thus give a increase in photocurrent. Lateral organic photodetectors are simple to design and have low dark current. The photo-response of these photo detectors is observed approximately three orders higher in magnitude compare able to its dark response. The dual layer has an advantage of tuning the devices for different absorption wavelengths and were observed more stable comparable to vertical devices.

  9. Robust lateral control of highway vehicles

    SciTech Connect

    Byrne, R.H.; Abdallah, C.

    1994-08-01

    Vehicle lateral dynamics are affected by vehicle mass, longitudinal velocity, vehicle inertia, and the cornering stiffness of the tires. All of these parameters are subject to variation, even over the course of a single trip. Therefore, a practical lateral control system must guarantee stability, and hopefully ride comfort, over a wide range of parameter changes. This paper describes a robust controller which theoretically guarantees stability over a wide range of parameter changes. The robust controller is designed using a frequency domain transfer function approach. An uncertainty band in the frequency domain is determined using simulations over the range of expected parameter variations. Based on this bound, a robust controller is designed by solving the Nevanlinna-Pick interpolation problem. The performance of the robust controller is then evaluated over the range of parameter variations through simulations.

  10. Customized MFM probes with high lateral resolution.

    PubMed

    Iglesias-Freire, Óscar; Jaafar, Miriam; Berganza, Eider; Asenjo, Agustina

    2016-01-01

    Magnetic force microscopy (MFM) is a widely used technique for magnetic imaging. Besides its advantages such as the high spatial resolution and the easy use in the characterization of relevant applied materials, the main handicaps of the technique are the lack of control over the tip stray field and poor lateral resolution when working under standard conditions. In this work, we present a convenient route to prepare high-performance MFM probes with sub-10 nm (sub-25 nm) topographic (magnetic) lateral resolution by following an easy and quick low-cost approach. This allows one to not only customize the tip stray field, avoiding tip-induced changes in the sample magnetization, but also to optimize MFM imaging in vacuum (or liquid media) by choosing tips mounted on hard (or soft) cantilevers, a technology that is currently not available on the market. PMID:27547625

  11. Customized MFM probes with high lateral resolution

    PubMed Central

    Jaafar, Miriam; Berganza, Eider; Asenjo, Agustina

    2016-01-01

    Summary Magnetic force microscopy (MFM) is a widely used technique for magnetic imaging. Besides its advantages such as the high spatial resolution and the easy use in the characterization of relevant applied materials, the main handicaps of the technique are the lack of control over the tip stray field and poor lateral resolution when working under standard conditions. In this work, we present a convenient route to prepare high-performance MFM probes with sub-10 nm (sub-25 nm) topographic (magnetic) lateral resolution by following an easy and quick low-cost approach. This allows one to not only customize the tip stray field, avoiding tip-induced changes in the sample magnetization, but also to optimize MFM imaging in vacuum (or liquid media) by choosing tips mounted on hard (or soft) cantilevers, a technology that is currently not available on the market. PMID:27547625

  12. Motorcycle state estimation for lateral dynamics

    NASA Astrophysics Data System (ADS)

    Teerhuis, A. P.; Jansen, S. T. H.

    2012-08-01

    The motorcycle lean (or roll) angle development is one of the main characteristics of motorcycle lateral dynamics. Control of motorcycle motions requires an accurate assessment of this quantity and for safety applications also the risk of sliding needs to be considered. Direct measurement of the roll angle and tyre slip is not available; therefore, a method of model-based estimation is developed to estimate the state of a motorcycle. This paper investigates the feasibility of such a motorcycle state estimator (MCSE). A simplified analytic model of a motorcycle is developed by comparison to an extended multi-body model of the motorcycle, designed in Matlab/SimMechanics. The analytic model is used inside an extended Kalman filter. Experimental results of an instrumented Yamaha FJR1300 motorcycle show that the MCSE is a feasible concept for obtaining signals related to the lateral dynamics of the motorcycle.

  13. Customized MFM probes with high lateral resolution.

    PubMed

    Iglesias-Freire, Óscar; Jaafar, Miriam; Berganza, Eider; Asenjo, Agustina

    2016-01-01

    Magnetic force microscopy (MFM) is a widely used technique for magnetic imaging. Besides its advantages such as the high spatial resolution and the easy use in the characterization of relevant applied materials, the main handicaps of the technique are the lack of control over the tip stray field and poor lateral resolution when working under standard conditions. In this work, we present a convenient route to prepare high-performance MFM probes with sub-10 nm (sub-25 nm) topographic (magnetic) lateral resolution by following an easy and quick low-cost approach. This allows one to not only customize the tip stray field, avoiding tip-induced changes in the sample magnetization, but also to optimize MFM imaging in vacuum (or liquid media) by choosing tips mounted on hard (or soft) cantilevers, a technology that is currently not available on the market.

  14. Lateralization Technique and Inferior Alveolar Nerve Transposition

    PubMed Central

    Sanches, Marco Antonio; Ramalho, Gabriel Cardoso; Manzi, Marcello Roberto

    2016-01-01

    Bone resorption of the posterior mandible can result in diminished bone edge and, therefore, the installation of implants in these regions becomes a challenge, especially in the presence of the mandibular canal and its contents, the inferior alveolar nerve. Several treatment alternatives are suggested: the use of short implants, guided bone regeneration, appositional bone grafting, distraction osteogenesis, inclined implants tangential to the mandibular canal, and the lateralization of the inferior alveolar nerve. The aim was to elucidate the success rate of implants in the lateralization technique and in inferior alveolar nerve transposition and to determine the most effective sensory test. We conclude that the success rate is linked to the possibility of installing implants with long bicortical anchor which favors primary stability and biomechanics. PMID:27433360

  15. Arthroscopic treatment for chronic lateral epicondylitis☆

    PubMed Central

    Terra, Bernardo Barcellos; Rodrigues, Leandro Marano; Filho, Anis Nahssen; de Almeida, Gustavo Dalla Bernardina; Cavatte, José Maria; De Nadai, Anderson

    2015-01-01

    Objective To report the clinical and functional results from arthroscopic release of the short radial extensor of the carpus (SREC) in patients with chronic lateral epicondylitis that was refractory to conservative treatment. Methods Over the period from January 2012 to November 2013, 15 patients underwent arthroscopic treatment. The surgical technique used was the one described by Romeo and Cohen, based on anatomical studies on cadavers. The inclusion criteria were that the patients needed to present lateral epicondylitis and that conservative treatment (analgesics, anti-inflammatory agents, corticoid infiltration or physiotherapy) had failed over a period of more than six months. The patients were evaluated based on the elbow functional score of the Mayo Clinic, Nirschl's staging system and a visual analog scale (VAS) for pain. Results A total of 15 patients (9 men and 6 women) were included. The mean Mayo elbow functional score after the operation was 95 (ranging from 90 to 100). The pain VAS improved from a mean of 9.2 before the operation to 0.64 after the operation. On Nirschl's scale, the patients presented an improvement from a mean of 6.5 before the operation to approximately one. There were significant differences from before to after the surgery for the three functional scores used (p < 0.01). No correlations were observed using the Spearman test between the results and age, gender, length of time with symptoms before the operation or injury mechanism (p > 0.05). Conclusion Arthroscopic treatment for lateral epicondylitis was shown to be a safe and effective therapeutic option when appropriately indicated and performed, in refractory cases of chronic lateral epicondylitis. It also allowed excellent viewing of the joint space for diagnosing and treating associated pathological conditions, with a minimally invasive procedure. PMID:26401498

  16. Osseous choristoma of the lateral canthus.

    PubMed

    Khan, Arif O; Al-Hussein, Hailah; Al-Katan, Hind

    2007-10-01

    Ocular osseous choristoma, a rare idiopathic benign deposit of bone, is typically a static epibulbar lesion that occurs sporadically in the supertemporal quadrant of an otherwise normal eye. The subject of this report is a unique U-shaped subcutaneous osseous choristoma that did not involve the eye itself but rather conformed to the right lateral canthus in an otherwise normal 2-year-old boy.

  17. Quantifiable Lateral Flow Assay Test Strips

    NASA Technical Reports Server (NTRS)

    2003-01-01

    As easy to read as a home pregnancy test, three Quantifiable Lateral Flow Assay (QLFA) strips used to test water for E. coli show different results. The brightly glowing control line on the far right of each strip indicates that all three tests ran successfully. But the glowing test line on the middle left and bottom strips reveal their samples were contaminated with E. coli bacteria at two different concentrations. The color intensity correlates with concentration of contamination.

  18. Endoscopic Ankle Lateral Ligament Graft Anatomic Reconstruction.

    PubMed

    Michels, Frederick; Cordier, Guillaume; Guillo, Stéphane; Stockmans, Filip

    2016-09-01

    Chronic instability is a common complication of lateral ankle sprains. If nonoperative treatment fails, a surgical repair or reconstruction may be indicated. Today, endoscopic techniques to treat ankle instability are becoming more popular. This article describes an endoscopic technique, using a step-by-step approach, to reconstruct the ATFL and CFL with a gracilis graft. The endoscopic technique is reproducible and safe with regard to the surrounding anatomic structures. Short and midterm results confirm the benefits of this technique. PMID:27524711

  19. Lateral distribution of electrons of air showers

    NASA Technical Reports Server (NTRS)

    Asakimori, K.; Maeda, T.; Kameda, T.; Mizushima, K.; Misaki, Y.

    1985-01-01

    The lateral distribution of electrons (LDE) of the air showers of size 10 to the 5th power to 10 to the 6th power was studied within one MU. It was found that the LDE of the air showers observed is well represented by NKG function except for vicinity of the core. It was also found that LDE measured by thin scintillators does not differ from that measured by thick ones of 50mm thickness.

  20. iPS Cells 10 Years Later.

    PubMed

    2016-09-01

    In 2006, Takahashi and Yamanaka reported the breakthrough discovery of induction of pluripotent stem cells from fibroblasts by a combination of defined factors. Ten years later, Cell editor João Monteiro brings together Shinya Yamanaka and Hans Schöler, one the original reviewers of the landmark study, to revisit the history behind the paper and its long-lasting legacy. PMID:27610558

  1. Tonoplast Aquaporins Facilitate Lateral Root Emergence.

    PubMed

    Reinhardt, Hagen; Hachez, Charles; Bienert, Manuela Désirée; Beebo, Azeez; Swarup, Kamal; Voß, Ute; Bouhidel, Karim; Frigerio, Lorenzo; Schjoerring, Jan K; Bennett, Malcolm J; Chaumont, Francois

    2016-03-01

    Aquaporins (AQPs) are water channels allowing fast and passive diffusion of water across cell membranes. It was hypothesized that AQPs contribute to cell elongation processes by allowing water influx across the plasma membrane and the tonoplast to maintain adequate turgor pressure. Here, we report that, in Arabidopsis (Arabidopsis thaliana), the highly abundant tonoplast AQP isoforms AtTIP1;1, AtTIP1;2, and AtTIP2;1 facilitate the emergence of new lateral root primordia (LRPs). The number of lateral roots was strongly reduced in the triple tip mutant, whereas the single, double, and triple tip mutants showed no or minor reduction in growth of the main root. This phenotype was due to the retardation of LRP emergence. Live cell imaging revealed that tight spatiotemporal control of TIP abundance in the tonoplast of the different LRP cells is pivotal to mediating this developmental process. While lateral root emergence is correlated to a reduction of AtTIP1;1 and AtTIP1;2 protein levels in LRPs, expression of AtTIP2;1 is specifically needed in a restricted cell population at the base, then later at the flanks, of developing LRPs. Interestingly, the LRP emergence phenotype of the triple tip mutants could be fully rescued by expressing AtTIP2;1 under its native promoter. We conclude that TIP isoforms allow the spatial and temporal fine-tuning of cellular water transport, which is critically required during the highly regulated process of LRP morphogenesis and emergence.

  2. Efferent pathways of the mouse lateral habenula

    PubMed Central

    Quina, Lely A.; Tempest, Lynne; Ng, Lydia; Harris, Julie; Ferguson, Susan; Jhou, Thomas; Turner, Eric E.

    2014-01-01

    The lateral habenula (LHb) is part of the habenula complex of the dorsal thalamus. Recent studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg), which contain GABAergic neurons that mediate reward prediction error via inhibition of dopaminergic activity. However, older studies in the rat have also identified LHb outputs to the lateral and posterior hypothalamus, median raphe, dorsal raphe, and dorsal tegmentum. Although these studies have shown that the medial and lateral divisions of the LHb have somewhat distinct projections, the topographic specificity of LHb efferents is not completely understood, and the relative extent of these projections to brainstem targets is unknown. Here we have used anterograde tracing with adeno-associated virus mediated expression of green fluorescent protein, combined with serial two-photon tomography, to map the efferents of the LHb on a standard coordinate system for the entire mouse brain, and reconstruct the efferent pathways of the LHb in three dimensions. Using automated quantitation of fiber density, we show that in addition to the RMTg, the median raphe, caudal dorsal raphe, and pontine central gray are major recipients of LHb efferents. Using retrograde tract tracing with cholera toxin subunit B, we show that LHb neurons projecting to the hypothalamus, VTA, median raphe, and caudal dorsal raphe, and pontine central gray reside in characteristic, but sometimes overlapping regions of the LHb. Together these results provide the anatomical basis for systematic studies of LHb function in neural circuits and behavior in mice. PMID:25099741

  3. [Special status of lateral clavicular fracture].

    PubMed

    Brunner, U; Habermeyer, P; Schweiberer, L

    1992-04-01

    Fractures of the lateral clavicle have different biomechanical conditions compared with fractures of the medial and central third; they therefore demand different therapy. Some 237 patients with fractures of the clavicle were followed, of which 75 (33%) were located in the lateral third of the clavicle. At the 5-year follow-up after exclusively conservative treatment, good results were found for Neer types I and III and 3 Jäger/Breitner type IIb fractures, while 4 out of 13 Jäger/Breitner type II a fractures ended in pseudarthroses (31%). Conservative treatment is recommended for Neer types I and III, as well as for the more stable Jäger/Breitner type II b and old II a fractures. Therefore, a new bandage is presented. It prevents the posterior and upward dislocation of the proximal fragment by vertical compression and rotation of the distal fragment by fixation of the arm. Open reduction and internal fixation by preferably extraarticular implants is recommended for unstable and dislocated Jäger/Breitner type II a fractures. For fractures of the lateral clavicle, good results can be achieved when the instability is recognized and adequately treated.

  4. Lateral jet injection into typical combustor flowfields

    NASA Technical Reports Server (NTRS)

    Lilley, D. G.

    1986-01-01

    The experimental problem of lateral jet injection into typical flow fields in the absence of combustion was studied. All flow fields being investigated have no expansion of the crossflow (the test section to swirler diameter ratio D/d = 1), after its passage through an optional swirler (with swirl vane angle phi = 0 (swirler removed), 45, and 70 degree). The lateral jet(s) is(are) located one test-section diameter downstream of the test-section inlet (x/D = 1). The lateral jets have round-sectioned nozzles, each of which has an area of 1/100th of the cross sectional area of the crossflow (A sub j/A sub c = 1/100). Jet-to-crossflow velocity ratios of R = v sub j/u sub o = 2, 4, and 6 were investigated. Helium-bubble low visualization, five-hole pitot probe time-mean velocity measurements, and single-wire time-mean velocity and normal and shear stress turbulence data were obtained in the research program.

  5. High performance amorphous selenium lateral photodetector

    NASA Astrophysics Data System (ADS)

    Abbaszadeh, Shiva; Allec, Nicholas; Karim, Karim S.

    2012-03-01

    Lateral amorphous selenium (a-Se) detectors based on the metal-semiconductor-metal (MSM) device structure have been studied for indirect detector medical imaging applications. These detectors have raised interest due to their simple structure, ease of fabrication, high-speed, low dark current, low capacitance per unit area and better light utilization. The lateral device structure has a benefit that the electrode spacing may be easily controlled to reduce the required bias for a given desired electric field. In indirect conversion x-ray imaging, the scintillator is coupled to the top of the a-Se MSM photodetector, which itself is integrated on top of the thin-film-transistor (TFT) array. The carriers generated at the top surface of the a-Se layer experience a field that is parallel to the surface, and does not initially sweep them away from the surface. Therefore these carriers may recombine or get trapped in surface states and change the field at the surface, which may degrade the performance of the photodetector. In addition, due to the finite width of the electrodes, the fill factor of the device is less than unity. In this study we examine the effect of lateral drift of carriers and the fill factor on the photodetector performance. The impact of field magnitude on the performance is also investigated.

  6. Lateral flow immunoassay using magnetoresistive sensors

    NASA Astrophysics Data System (ADS)

    Taton, Kristin; Johnson, Diane; Guire, Patrick; Lange, Erik; Tondra, Mark

    2009-05-01

    Magnetic particles have been adapted for use as labels in biochemical lateral flow strip tests. Standard gold particle lateral flow assays are generally qualitative; however, with magnetic particles, quantitative results can be obtained by using electronic detection systems with giant magnetoresistive (GMR) sensors. As described here, these small integrated sensor chips can detect the presence of magnetic labels in capture spots whose volume is approximately 150 μm×150 μm×150 μm. The range of linear detection is better than two orders of magnitude; the total range is up to four orders of magnitude. The system was demonstrated with both indirect and sandwich enzyme-linked immunosorbent assays (ELISAs) for protein detection of rabbit IgG and interferon-γ, respectively, achieving detection of 12 pg/ml protein. Ultimately, the goal is for the detector to be fully integrated into the lateral flow strip backing to form a single consumable item that is interrogated by a handheld electronic reader.

  7. Lateral approach for supraclavicular brachial plexus block

    PubMed Central

    Sahu, DK; Sahu, Anjana

    2010-01-01

    A lateral approach described by Volker Hempel and Dr. Dilip Kotharihas been further studied, evaluated and described in detail in the present study. The aim of this study was to evaluate lateral approach of supraclavicular brachial plexus block, mainly in terms of successes rate and complication rate. The study was conducted in secondary level hospital and tertiary level hospital from 2004 to 2008. It was a prospective nonrandomized open-level study. Eighty-two patients of both sexes, aged between 18 and 65 years with ASA Grade I and II scheduled to undergo elective major surgery of the upper limb below the midarm, were selected for this new lateral approach of brachial plexus block. The onset and duration of sensory and motor block, any complications and need for supplement anaesthesia were observed. Success and complication rate were calculated in percentage. Average onset and duration of sensory and motor block was calculated as mean ± SD and percentage. Out of 82 patients, 75 (92%) have got successful block with no significant complication in any case. PMID:20885867

  8. Transnational connections of later-life migrants.

    PubMed

    Heikkinen, Sari Johanna; Lumme-Sandt, Kirsi

    2013-04-01

    In this paper a transnational perspective is used to explain whether and how older migrants construct and sustain their social networks. The paper uses a transnational viewpoint on older migrants' lives by analysing their engagement with their former homeland, and the intensity and habitualness of those engagements in old age. The aim of this article is to study the transnational connections of later-life migrants'. Attention is especially paid to the features of old age while maintaining these connections. These considerations are based on analyses of transnational networks in the everyday lives of later-life migrants from the former Soviet Union residing in Finland. The data were collected from 11 later-life migrants. It is found that transnational relationships are a vital part of the everyday lives of older migrants, and that they are sustained in varied ways. These connections mean a concrete source of help, family affiliations, the sharing of emotions, and a larger social network. Economic limitations affect the frequency and type of communication, and various physical limitations may also cause inability to maintain contacts across borders. In these circumstances, family members or other close relatives or friends are needed to deliver messages on the older person's behalf. Old age and immigration status affect the amount and direction of communication across borders, thereby shaping these networks. PMID:23561285

  9. Perturbations Caused by Lateral Stress Gauges

    NASA Astrophysics Data System (ADS)

    Winter, R. E.; Harris, E. J.

    2007-12-01

    In principle, stress gauges mounted to measure lateral stresses in a shocked matrix allow the shear strength of the material to be determined. Interpreting the records from lateral stress gauges is hindered by the fact that the stress field in the insulating layer in which the gauges are mounted can differ signifcantly from the stress field that would be generated in the sample if no gauge were present. A series of high resolution Eulerian code calculations have been run which suggest that the stresses in the insulating layer vary with distance and time in a way that depends on the thickness of the layer, the shock strength, and the elastic and plastic properties of both the layer and the matrix. In particular, if the shock velocity in the matrix material is high the stress at a typical gauge position initially rises to a sharp peak then falls with time, but when the shock velocity in the matrix is low the stress rises relatively gradually throughout the time of interest. The shapes of the stress-time profiles predicted by the hydrocode compare well with the results of lateral gauge experiments on several different materials.

  10. Perturbations Caused by Lateral Stress Gauges

    NASA Astrophysics Data System (ADS)

    Winter, Ron; Harris, Ernie

    2007-06-01

    In principle, stress gauges mounted to measure lateral stresses in a shocked matrix allow the shear strength of the material to be determined. Interpreting the records from lateral stress gauges is hindered by the fact that the stress field in the insulating layer in which the gauges are mounted can differ significantly from the stress field that would be generated in the sample if no gauge were present. A series of high resolution Eulerian code calculations have been run which suggest that the stresses in the insulating layer vary with distance and time in a way that depends on the thickness of the layer, the shock strength, and the elastic and plastic properties of both the layer and the matrix. In particular, if the shock velocity in the matrix material is high the stress at a typical gauge position initially rises to a sharp peak then falls with time, but when the shock velocity in the matrix is low the stress rises relatively gradually throughout the time of interest. The shapes of the stress-time profiles predicted by the hydrocode compare well with the results of lateral gauge experiments on several different materials.

  11. Lateral shear-moraines and lateral marginal-moraines of palaeo-ice streams

    NASA Astrophysics Data System (ADS)

    Batchelor, C. L.; Dowdeswell, J. A.

    2016-11-01

    An understanding of the nature of sedimentation at ice-stream lateral margins is important in reconstructing the dynamics of former ice sheets and modelling the mechanisms by which sediment is transported beneath contemporary ice streams. Theories of the formation of ice-stream lateral moraines (ISLMs) have hitherto been based on a relatively limited number of terrestrial and marine examples. Here, an inventory of ISLMs is compiled from available studies, together with independent analysis of seismic-reflection and bathymetric datasets. The locations and dimensions of 70 ISLMs, alongside a synthesis of their key architectural and geomorphic characteristics, are presented. Two different types of ISLMs are identified. Type 1 ISLMs are up to 3.5 km wide and 60 m thick. They maintain a constant width, thickness and cross-sectional shape along their length. Type 1 ISLMs are interpreted and referred to as ice-stream lateral shear-moraines that form subglacially in the shear zone between ice streams and slower-flowing regions of an ice sheet. In contrast, Type 2 ISLMs are up to 50 km wide and 300 m thick. They are only identified close to the shelf break in the marine environment. Type 2 ISLMs exhibit an increase in width and thickness along their length and their distal slopes become steeper in a seaward direction. They contain internal dipping reflections that indicate sediment progradation away from the former ice stream. Type 2 ISLMs are interpreted and referred to as ice-stream lateral marginal-moraines that were formed at the lateral boundary between ice streams and seafloor terrain that was free of grounded ice. We suggest that, using bathymetric images and acoustic profiles, it is possible to differentiate between ice-stream lateral shear-moraines and lateral marginal-moraines in the geological record. This distinction is important for understanding the mechanisms of sediment transfer beneath ice streams and for making inferences about the conditions that existed

  12. Lateralization of the Pharyngeal Flap for Treatment of Lateral Velopharyngeal Gap.

    PubMed

    Abdel-Aziz, Mosaad; Rashed, Mohammed; Naguib, Nader; Shawky, Ahmed

    2016-01-01

    Pharyngeal flap is usually used for treatment of velopharyngeal insufficiency (VPI); it is bridged between the posterior pharyngeal wall and the soft palate traversing the central part of the velopharyngeal port. The aim of this study was to assess the efficacy of lateralization of the pharyngeal flap for treatment of VPI in patients with lateral velopharyngeal gap. Fifteen patients with VPI due to lateral velopharyngeal gap were subjected to closure of the gap by pharyngeal flap that was lateralized to fill the gap. Preoperative and postoperative assessment of velopharyngeal functions including flexible nasopharyngoscopy, auditory perceptual assessment (APA), and nasometric assessment were performed. Postoperatively, flexible nasopharyngoscopy showed complete velopharyngeal closure in all the patients, with significant improvement of speech parameters as measured by APA. Also, nasalance score showed significant improvement for oral and nasal sentences that was measured by nasometry. Lateralization of the pharyngeal flap for treatment of VPI in patients with lateral velopharyngeal gap is an effective method; it improves the velopharyngeal closure and the speech of the patients. PMID:26745192

  13. High Risk of Lateral Nodal Metastasis in Lateral Solitary Solid Papillary Thyroid Cancer.

    PubMed

    Lai, Xing-Jian; Zhang, Bo; Jiang, Yu-Xin; Li, Jian-Chu; Zhao, Rui-Na; Yang, Xiao; Zhang, Qing; Zhang, Xiao-Yan; Li, Wen-Bo; Zhu, Shen-Ling

    2016-01-01

    We explored the relationship between ultrasonic intra-thyroidal location and neck node metastasis pattern in solitary solid papillary thyroid cancer (PTC). Data on 186 patients were retrospectively reviewed. The association between several characteristics and neck node metastasis pattern were analyzed. Among the 186 thyroid nodules, age ≥45 y (p = 0.005), mass size ≥2 cm (p = 0.001), presence of calcifications (p < 0.001) and lateral nodal metastasis (p = 0.001) were significantly related to central nodal metastasis in multivariate analysis. Mass size ≥2 cm (p = 0.046) and central nodal metastasis (p = 0.002) were significantly related to lateral nodal metastasis in multivariate analysis. Location of an intra-thyroidal solitary solid PTC located non-adjacent to the trachea (lateral) was significantly related to lateral nodal metastasis (p = 0.043) compared with location of an intra-thyroidal solitary solid PTC adjacent to the trachea (medial or isthmus). Lateral lesions have a high risk of lateral nodal metastasis in solitary solid PTC.

  14. Early Adolescent Affect Predicts Later Life Outcomes

    PubMed Central

    Kansky, Jessica; Allen, Joseph P.; Diener, Ed

    2016-01-01

    Background Subjective well-being as a predictor for later behavior and health has highlighted its relationship to health, work performance, and social relationships. However, the majority of such studies neglect the developmental nature of well-being in contributing to important changes across the transition to adulthood. Methods To examine the potential role of subjective well-being as a long-term predictor of critical life outcomes, we examined indicators of positive and negative affect at age 14 as a predictor of relationship, adjustment, self worth, and career outcomes a decade later at ages 23 to 25, controlling for family income and gender. We utilized multi-informant methods including reports from the target participant, close friends, and romantic partners in a demographically diverse community sample of 184 participants. Results Early adolescent positive affect predicted less relationship problems (less self-reported and partner-reported conflict, greater friendship attachment as rated by close peers), healthy adjustment to adulthood (lower levels of depression, anxiety, and loneliness). It also predicted positive work functioning (higher levels of career satisfaction and job competence) and increased self-worth. Negative affect did not significantly predict any of these important life outcomes. In addition to predicting desirable mean levels of later outcomes, early positive affect predicted beneficial changes across time in many outcomes. Conclusions The findings extend early research on the beneficial outcomes of subjective well-being by having an earlier assessment of well-being, including informant reports in measuring a large variety of outcome variables, and by extending the findings to a lower socioeconomic group of a diverse and younger sample. The results highlight the importance of considering positive affect as an important component of subjective well-being distinct from negative affect. PMID:27075545

  15. Efferent pathways of the mouse lateral habenula.

    PubMed

    Quina, Lely A; Tempest, Lynne; Ng, Lydia; Harris, Julie A; Ferguson, Susan; Jhou, Thomas C; Turner, Eric E

    2015-01-01

    The lateral habenula (LHb) is part of the habenula complex of the dorsal thalamus. Recent studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg), which contain γ-aminobutyric acid (GABA)ergic neurons that mediate reward prediction error via inhibition of dopaminergic activity. However, older studies in the rat have also identified LHb outputs to the lateral and posterior hypothalamus, median raphe, dorsal raphe, and dorsal tegmentum. Although these studies have shown that the medial and lateral divisions of the LHb have somewhat distinct projections, the topographic specificity of LHb efferents is not completely understood, and the relative extent of these projections to brainstem targets is unknown. Here we have used anterograde tracing with adeno-associated virus-mediated expression of green fluorescent protein, combined with serial two-photon tomography, to map the efferents of the LHb on a standard coordinate system for the entire mouse brain, and reconstruct the efferent pathways of the LHb in three dimensions. Using automated quantitation of fiber density, we show that in addition to the RMTg, the median raphe, caudal dorsal raphe, and pontine central gray are major recipients of LHb efferents. By using retrograde tract tracing with cholera toxin subunit B, we show that LHb neurons projecting to the hypothalamus, VTA, median raphe, caudal dorsal raphe, and pontine central gray reside in characteristic, but sometimes overlapping regions of the LHb. Together these results provide the anatomical basis for systematic studies of LHb function in neural circuits and behavior in mice. J. Comp. Neurol. 523:32-60, 2015. © 2014 Wiley Periodicals, Inc. PMID:25099741

  16. Lateral scanning white-light interferometer.

    PubMed

    Olszak, A

    2000-08-01

    White-light vertical scanning interferometry is a well-established technique for retrieving the three-dimensional shapes of small objects, but it can measure only areas as big as the field of view of the instrument. For bigger fields a stitching algorithm must be applied, which often can be a source of errors. A technique in which the object is scanned laterally in front of an instrument with a tilted coherence plane is described. It permits measurements at higher speeds while measurement accuracy is retained and eliminates the need for stitching in one direction. Experimental confirmation is provided.

  17. Lateral elbow tendinopathy: Evidence of physiotherapy management.

    PubMed

    Dimitrios, Stasinopoulos

    2016-08-18

    Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed in the management of LET. The exercise programme is the most common treatment in the management of LET. The optimal protocol of exercise programme is still unknown. The effectiveness of the exercise programme is low when it is applied as monotherapy. Therefore, exercise programme is combined with other physiotherapy modalities such as soft tissue techniques, external support, acupuncture, manual therapy and electrotherapy, in the treatment of LET. Future research is needed to determine which treatment strategy combined with exercise programme will provide the best results in LET rehabilitation. PMID:27622145

  18. Lateral elbow tendinopathy: Evidence of physiotherapy management

    PubMed Central

    Dimitrios, Stasinopoulos

    2016-01-01

    Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed in the management of LET. The exercise programme is the most common treatment in the management of LET. The optimal protocol of exercise programme is still unknown. The effectiveness of the exercise programme is low when it is applied as monotherapy. Therefore, exercise programme is combined with other physiotherapy modalities such as soft tissue techniques, external support, acupuncture, manual therapy and electrotherapy, in the treatment of LET. Future research is needed to determine which treatment strategy combined with exercise programme will provide the best results in LET rehabilitation. PMID:27622145

  19. Lateral chirality-sorting optical forces.

    PubMed

    Hayat, Amaury; Mueller, J P Balthasar; Capasso, Federico

    2015-10-27

    The transverse component of the spin angular momentum of evanescent waves gives rise to lateral optical forces on chiral particles, which have the unusual property of acting in a direction in which there is neither a field gradient nor wave propagation. Because their direction and strength depends on the chiral polarizability of the particle, they act as chirality-sorting and may offer a mechanism for passive chirality spectroscopy. The absolute strength of the forces also substantially exceeds that of other recently predicted sideways optical forces. PMID:26453555

  20. Lateral elbow tendinopathy: Evidence of physiotherapy management.

    PubMed

    Dimitrios, Stasinopoulos

    2016-08-18

    Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed in the management of LET. The exercise programme is the most common treatment in the management of LET. The optimal protocol of exercise programme is still unknown. The effectiveness of the exercise programme is low when it is applied as monotherapy. Therefore, exercise programme is combined with other physiotherapy modalities such as soft tissue techniques, external support, acupuncture, manual therapy and electrotherapy, in the treatment of LET. Future research is needed to determine which treatment strategy combined with exercise programme will provide the best results in LET rehabilitation.

  1. Lateral elbow tendinopathy: Evidence of physiotherapy management

    PubMed Central

    Dimitrios, Stasinopoulos

    2016-01-01

    Lateral elbow tendinopathy (LET) is a common musculoskeletal/sports injury. A plethora of physiotherapy techniques has been proposed in the management of LET. The exercise programme is the most common treatment in the management of LET. The optimal protocol of exercise programme is still unknown. The effectiveness of the exercise programme is low when it is applied as monotherapy. Therefore, exercise programme is combined with other physiotherapy modalities such as soft tissue techniques, external support, acupuncture, manual therapy and electrotherapy, in the treatment of LET. Future research is needed to determine which treatment strategy combined with exercise programme will provide the best results in LET rehabilitation.

  2. Towards reproducible, scalable lateral molecular electronic devices

    SciTech Connect

    Durkan, Colm Zhang, Qian

    2014-08-25

    An approach to reproducibly fabricate molecular electronic devices is presented. Lateral nanometer-scale gaps with high yield are formed in Au/Pd nanowires by a combination of electromigration and Joule-heating-induced thermomechanical stress. The resulting nanogap devices are used to measure the electrical properties of small numbers of two different molecular species with different end-groups, namely 1,4-butane dithiol and 1,5-diamino-2-methylpentane. Fluctuations in the current reveal that in the case of the dithiol molecule devices, individual molecules conduct intermittently, with the fluctuations becoming more pronounced at larger biases.

  3. Lateral Interactions in Monolayer Thick Mercury Films

    NASA Astrophysics Data System (ADS)

    Kime, Yolanda Jan

    An understanding of lateral adatom-adatom interactions is often an important part of understanding electronic structure and adsorption energetics in monolayer thick films. In this dissertation I use angle-resolved photoemission and thermal desorption spectroscopies to explore the relationship between the adatom-adatom interaction and other characteristics of the adlayer, such as electronic structure, defects, or coexistent structural phases in the adlayer. Since Hg binds weakly to many substrates, the lateral interactions are often a major contribution to the dynamics of the overlayer. Hg adlayer systems are thus ideal for probing lateral interactions. The electronic structures of Hg adlayers on Ag(100), Cu(100), and Cu_3Au(100) are studied with angle-resolved ultraviolet photoemission. The Hg atomic 5d_{5/2} electronic band is observed to split into two levels following adsorption onto some surfaces. The energetic splitting of the Hg 5d_{5/2} level is found to be directly correlated to the adlayer homogeneous strain energy. The existence of the split off level also depends on the order or disorder of the Hg adlayer. The energetics of Hg adsorption on Cu(100) are probed using thermal desorption spectroscopy. Two different ordered adlayer structures are observed for Hg adsorption on Cu(100) at 200 K. Under some adsorption conditions and over a range of exposures, the two phases are seen to coexist on the surface prior to the thermal desorption process. A phase transition from the more dense to the less dense phase is observed to occur during the thermal desorption process. Inherent differences in defect densities are responsible for the observed differences between lateral interactions measured previously with equilibrium (atom beam scattering) and as measured by the non-equilibrium (thermal desorption) technique reported here. Theoretical and experimental evidence for an indirect through-metal interaction between adatoms is also discussed. Although through

  4. Nappe emplacement under lateral pressure gradient

    NASA Astrophysics Data System (ADS)

    Podladchikov, Yury; Schmalholz, Stefan

    2014-05-01

    New thin viscous approximation is under development specifically targeted to model spontaneous initiation and tens of kilometers horizontal displacement of tectonic nappes. Nappes are few kilometers thing and tens of kilometers long rock units trusted towards foreland often preserving internal lithological consistency and laying at near horizontal position at the end of the emplacement. Significant shear stresses and deviation of principal stresses from vertical is required to explain this very peculiar strain localization style from mechanical point of view. There is also a need for the explanation of their common appearances in most collisional settings. Both pure shear thin sheet and flexural models kinematically eliminate nappes formation. Spreading viscous sheet models, such as used to model glaciers, are also not applicable as the direction of motion is upward, against gravity. The reason for this discrepancy is the hydrostatic pressure approximation of the gravity-driven spreading models. Actually, the thin sheet approximation is not sensitive to the assumptions made on pressure profile. Lateral non-lithostatic pressure gradient-driven viscous sheet model is appropriate for modeling of nappes. In turn, significant non-lithostatic pressure must be supported by flexural rigidity of overlying and underlying units. Lateral gradients of this non-lithostatic pressure are responsible for the significant shear stress and, therefore, deviation of principal stress from vertical.

  5. Prototype cantilevers for quantitative lateral force microscopy

    SciTech Connect

    Reitsma, Mark G.; Gates, Richard S.; Friedman, Lawrence H.; Cook, Robert F.

    2011-09-15

    Prototype cantilevers are presented that enable quantitative surface force measurements using contact-mode atomic force microscopy (AFM). The ''hammerhead'' cantilevers facilitate precise optical lever system calibrations for cantilever flexure and torsion, enabling quantifiable adhesion measurements and friction measurements by lateral force microscopy (LFM). Critically, a single hammerhead cantilever of known flexural stiffness and probe length dimension can be used to perform both a system calibration as well as surface force measurements in situ, which greatly increases force measurement precision and accuracy. During LFM calibration mode, a hammerhead cantilever allows an optical lever ''torque sensitivity'' to be generated for the quantification of LFM friction forces. Precise calibrations were performed on two different AFM instruments, in which torque sensitivity values were specified with sub-percent relative uncertainty. To examine the potential for accurate lateral force measurements using the prototype cantilevers, finite element analysis predicted measurement errors of a few percent or less, which could be reduced via refinement of calibration methodology or cantilever design. The cantilevers are compatible with commercial AFM instrumentation and can be used for other AFM techniques such as contact imaging and dynamic mode measurements.

  6. Religious Attendance and Loneliness in Later Life

    PubMed Central

    Rote, Sunshine; Hill, Terrence D.; Ellison, Christopher G.

    2013-01-01

    Purpose of the Study:  Studies show that loneliness is a major risk factor for health issues in later life. Although research suggests that religious involvement can protect against loneliness, explanations for this general pattern are underdeveloped and undertested. In this paper, we propose and test a theoretical model, which suggests that social integration and social support are key mechanisms that link religious attendance and loneliness. Design and Methods:  To formally test our theoretical model, we use data from the National Social Life Health and Aging Project (2005/2006), a large national probability sample of older adults aged 57–85 years. Results:  We find that religious attendance is associated with higher levels of social integration and social support and that social integration and social support are associated with lower levels of loneliness. A series of mediation tests confirm our theoretical model. Implications:  Taken together, our results suggest that involvement in religious institutions may protect against loneliness in later life by integrating older adults into larger and more supportive social networks. Future research should test whether these processes are valid across theoretically relevant subgroups. PMID:22555887

  7. Semantic deficits in amyotrophic lateral sclerosis.

    PubMed

    Leslie, Felicity V C; Hsieh, Sharpley; Caga, Jashelle; Savage, Sharon A; Mioshi, Eneida; Hornberger, Michael; Kiernan, Matthew C; Hodges, John R; Burrell, James R

    2015-03-01

    Our objective was to investigate, and establish neuroanatomical correlates of, semantic deficits in amyotrophic lateral sclerosis (ALS) and amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD), compared to semantic dementia (SD) and controls. Semantic deficits were evaluated using a naming and semantic knowledge composite score, comprising verbal and non-verbal neuropsychological measures of single-word processing (confrontational naming, comprehension, and semantic association) from the Sydney Language Battery (SYDBAT) and Addenbrooke's Cognitive Examination - Revised (ACE-R). Voxel based morphometry (VBM) analysis was conducted using the region of interest approach. In total, 84 participants were recruited from a multidisciplinary research clinic in Sydney. Participants included 17 patients with ALS, 19 with ALS-FTD, 22 with SD and 26 age- and education-matched healthy controls. Significant semantic deficits were observed in ALS and ALS-FTD compared to controls. The severity of semantic deficits varied across the clinical phenotypes: ALS patients were less impaired than ALS-FTD patients, who in turn were not as impaired as SD patients. Anterior temporal lobe atrophy significantly correlated with semantic deficits. In conclusion, semantic impairment is a feature of ALS and ALS-FTD, and reflects the severity of temporal lobe pathology.

  8. Amyotrophic lateral sclerosis: one or multiple causes?

    PubMed Central

    Bastos, Aline Furtado; Orsini, Marco; Machado, Dionis; Mello, Mariana Pimentel; Nader, Sergio; Silva, Júlio Guilherme; da Silva Catharino, Antonio M.; de Freitas, Marcos R.G.; Pereira, Alessandra; Pessoa, Luciane Lacerda; Sztajnbok, Flavio R.; Leite, Marco Araújo; Nascimento, Osvaldo J.M.; Bastos, Victor Hugo

    2011-01-01

    The Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in the adulthood, and it is characterized by rapid and progressive compromise of the upper and lower motor neurons. The majority of the cases of ALS are classified as sporadic and, until now, a specific cause for these cases still is unknown. To present the different hypotheses on the etiology of ALS. It was carried out a search in the databases: Bireme, Scielo and Pubmed, in the period of 1987 to 2011, using the following keywords: Amyotrophic lateral sclerosis, motor neuron disease, etiology, causes and epidemiology and its similar in Portuguese and Spanish. It did not have consensus as regards the etiology of ALS. Researches demonstrates evidences as regards intoxication by heavy metals, environmental and occupational causes, genetic mutations (superoxide dismutase 1), certain viral infections and the accomplishment of vigorous physical activity for the development of the disease. There is still no consensus regarding the involved factors in the etiology of ALS. In this way, new research about these etiologies are necessary, for a better approach of the patients, promoting preventive programs for the disease and improving the quality of life of the patients. PMID:21785676

  9. Lateral Gene Transfer from the Dead

    PubMed Central

    Szöllősi, Gergely J.; Tannier, Eric; Lartillot, Nicolas; Daubin, Vincent

    2013-01-01

    In phylogenetic studies, the evolution of molecular sequences is assumed to have taken place along the phylogeny traced by the ancestors of extant species. In the presence of lateral gene transfer, however, this may not be the case, because the species lineage from which a gene was transferred may have gone extinct or not have been sampled. Because it is not feasible to specify or reconstruct the complete phylogeny of all species, we must describe the evolution of genes outside the represented phylogeny by modeling the speciation dynamics that gave rise to the complete phylogeny. We demonstrate that if the number of sampled species is small compared with the total number of existing species, the overwhelming majority of gene transfers involve speciation to and evolution along extinct or unsampled lineages. We show that the evolution of genes along extinct or unsampled lineages can to good approximation be treated as those of independently evolving lineages described by a few global parameters. Using this result, we derive an algorithm to calculate the probability of a gene tree and recover the maximum-likelihood reconciliation given the phylogeny of the sampled species. Examining 473 near-universal gene families from 36 cyanobacteria, we find that nearly a third of transfer events (28%) appear to have topological signatures of evolution along extinct species, but only approximately 6% of transfers trace their ancestry to before the common ancestor of the sampled cyanobacteria. [Gene tree reconciliation; lateral gene transfer; macroevolution; phylogeny.] PMID:23355531

  10. Transmembrane voltage: Potential to induce lateral microdomains.

    PubMed

    Malinsky, Jan; Tanner, Widmar; Opekarova, Miroslava

    2016-08-01

    Lateral segregation of plasma membrane lipids is a generally accepted phenomenon. Lateral lipid microdomains of specific composition, structure and biological functions are established as a result of simultaneous action of several competing mechanisms which contribute to membrane organization. Various lines of evidence support the conclusion that among those mechanisms, the membrane potential plays significant and to some extent unique role. Above all, clear differences in the microdomain structure as revealed by fluorescence microscopy could be recognized between polarized and depolarized membranes. In addition, recent fluorescence spectroscopy experiments reported depolarization-induced changes in a membrane lipid order. In the context of earlier findings showing that plasma membranes of depolarized cells are less susceptible to detergents and the cells less sensitive to antibiotics or antimycotics treatment we discuss a model, in which membrane potential-driven re-organization of the microdomain structure contributes to maintaining membrane integrity during response to stress, pathogen attack and other challenges involving partial depolarization of the plasma membrane. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. PMID:26902513

  11. Radiotherapy reduces sialorrhea in amyotrophic lateral sclerosis.

    PubMed

    Neppelberg, E; Haugen, D F; Thorsen, L; Tysnes, O-B

    2007-12-01

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Sialorrhea is a frequent problem in ALS patients with bulbar symptoms, because of progressive weakness of oral, lingual and pharyngeal muscles. This prospective study aimed to investigate the putative effect of palliative single-dose radiotherapy on problematic sialorrhea in patients with ALS. Twenty patients with ALS and problematic drooling were included; 14 were given radiotherapy with a single fraction of 7.5 Grey (Gy). Five patients were treated with botulinum toxin A (BTX-A) injections (20 U) into the parotid glands; two of these were later given radiotherapy. Symptom assessment, clinical examination and measurements of salivary flow (ml/min) were performed before and after treatment (1-2 weeks, 3 months). Salivary secretion was significantly reduced after radiation treatment, with a mean reduction of 60% (1 week) and 51% (2 weeks). Three months post-treatment, 21% reduction of the salivary secretion was observed compared with salivation before treatment. Mean salivary flow was not reduced after BTX-A treatment in five patients. No serious side-effects were observed with either of the two treatment modalities. Single-dose radiotherapy (7.5 Gy) significantly reduces sialorrhea and is an effective and safe palliative treatment in patients with ALS.

  12. Inhibitory Fields in the Limulus Lateral Eye

    PubMed Central

    Barlow, Robert B.

    1969-01-01

    The inhibition that is exerted mutually among receptor units (ommatidia) of the lateral eye of Limulus does not diminish uniformly with increasing distance between units. Instead the response of a receptor unit is most effectively inhibited by other units separated from it by approximately 1 mm (three to five receptor diameters); the effectiveness diminishes with distances both greater and less than this value. The ommatidial inhibitory field as measured by the spatial function of the inhibitory coefficients contains a uniform depression in the central region, a uniformly high annulus at some distance from the center, and a gradual tapering off toward the periphery. The field is large—covering over 30 % of the retina—and is somewhat elliptical in shape with its major axis in the anteroposterior direction on the lateral eye. A number of experiments reveal similar configurations in a sizable part of the eye. Control experiments show that the diminution of the inhibitory effects near the center of the field is not an artifact of the measuring technique and cannot be explained readily by local neural excitatory processes. PMID:5806596

  13. Lateralization of auditory-cortex functions.

    PubMed

    Tervaniemi, Mari; Hugdahl, Kenneth

    2003-12-01

    In the present review, we summarize the most recent findings and current views about the structural and functional basis of human brain lateralization in the auditory modality. Main emphasis is given to hemodynamic and electromagnetic data of healthy adult participants with regard to music- vs. speech-sound encoding. Moreover, a selective set of behavioral dichotic-listening (DL) results and clinical findings (e.g., schizophrenia, dyslexia) are included. It is shown that human brain has a strong predisposition to process speech sounds in the left and music sounds in the right auditory cortex in the temporal lobe. Up to great extent, an auditory area located at the posterior end of the temporal lobe (called planum temporale [PT]) underlies this functional asymmetry. However, the predisposition is not bound to informational sound content but to rapid temporal information more common in speech than in music sounds. Finally, we obtain evidence for the vulnerability of the functional specialization of sound processing. These altered forms of lateralization may be caused by top-down and bottom-up effects inter- and intraindividually In other words, relatively small changes in acoustic sound features or in their familiarity may modify the degree in which the left vs. right auditory areas contribute to sound encoding. PMID:14629926

  14. Lateral epicondylalgia: midlife crisis of a tendon.

    PubMed

    Luk, James K H; Tsang, Raymond C C; Leung, H B

    2014-04-01

    The pathogenesis and management of lateral epicondylalgia, or tennis elbow, a common ailment affecting middle-aged subjects of both genders continue to provoke controversy. Currently it is thought to be due to local tendon pathology, pain system changes, and motor system impairment. Its diagnosis is usually clinical, based on a classical history, as well as symptoms and signs. In selected cases, additional imaging (X-rays, ultrasound, and magnetic resonance imaging) can help to confirm the diagnosis. Different treatment modalities have been described, including the use of orthotics, non-steroidal anti-inflammatory drugs, steroid injections, topical glyceryl trinitrate, exercise therapy, manual therapy, ultrasound therapy, laser therapy, extracorporeal shockwave therapy, acupuncture, taping, platelet-rich plasma injections, hyaluronan gel injections, botulinum toxin injections, and surgery. Nevertheless, evidence to select the best treatment is lacking and the choice of therapy depends on the experience of the management team, availability of the equipment and expertise, and patient response. This article provides a snapshot of current medical practice for lateral epicondylalgia management.

  15. Dual-domain lateral shearing interferometer

    DOEpatents

    Naulleau, Patrick P.; Goldberg, Kenneth Alan

    2004-03-16

    The phase-shifting point diffraction interferometer (PS/PDI) was developed to address the problem of at-wavelength metrology of extreme ultraviolet (EUV) optical systems. Although extremely accurate, the fact that the PS/PDI is limited to use with coherent EUV sources, such as undulator radiation, is a drawback for its widespread use. An alternative to the PS/PDI, with relaxed coherence requirements, is lateral shearing interferometry (LSI). The use of a cross-grating, carrier-frequency configuration to characterize a large-field 4.times.-reduction EUV lithography optic is demonstrated. The results obtained are directly compared with PS/PDI measurements. A defocused implementation of the lateral shearing interferometer in which an image-plane filter allows both phase-shifting and Fourier wavefront recovery. The two wavefront recovery methods can be combined in a dual-domain technique providing suppression of noise added by self-interference of high-frequency components in the test-optic wavefront.

  16. Amyotrophic lateral sclerosis disease progression model.

    PubMed

    Gomeni, Roberto; Fava, Maurizio

    2014-03-01

    Our objective was to develop: 1) a longitudinal model to describe amyotrophic lateral sclerosis (ALS) disease progression using the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R); and 2) a probabilistic model to estimate the presence of clusters of trajectories in ALS progression over 12 months of treatment. Three hundred and thirty-eight patients treated with placebo from the PRO-ACT database were included in the analyses. A non-linear Weibull model best described the ALS disease progression, and a stepwise logistic regression approach was used to select the variables predicting a slow or fast disease progression. Results identified two clusters of trajectories: 1) slow disease progressors (46% of patients with a change from baseline of 13%); 2) fast disease progressors (54% of patients with a change from baseline of 49%). ROC curve analysis estimated the optimal cut-off for classifying patients as slow or fast disease progressors given ALSFRS-R measurements at 2-4 weeks. Results showed that the degree of ALS disease progression quantified by the ALSFRS-R symptomatic change on placebo is highly heterogeneous. In conclusion, this finding indicates the potential interest of disease progression models for implementing a population enrichment strategy to control the level of heterogeneity in the patients included in new trials.

  17. Confronting the Material Convoy in Later Life

    PubMed Central

    Smith, Gabriella V.; Ekerdt, David J.

    2011-01-01

    We adapt a metaphor from life course studies to designate the whole of one’s possessions, across time, as a convoy of material support. This dynamic collection of things supports daily life and the self, but it can also present difficulty in later life. To alleviate the purported burdens of the material convoy, a discourse has arisen that urges elders and their family members to reduce the volume of possessions. An analysis of 11 such possession management texts shows authors addressing two distinct audiences about elders’ need to downsize: family members and elders themselves. Authors who speak to family members do so with an urgent, unsentimental tone that echoes mainstream clutter-control advice about disorderly, overfull households. In texts for elders, the standard critique about consumption and unruly lives is gentler, more sensitive to the meaning of things, and underplays the emotions of divestment. There is stress on the responsibility to spare the next generation and control one’s legacy. These latter texts seem to respect that downsizing in later life symbolizes a narrowing of the life world. PMID:21822336

  18. [Methodology in studying laterality in developmental neuropsychiatry].

    PubMed

    Mitrović, D; Nikolić, V; Vlajković, K

    1991-01-01

    The extent of literature and research dedicated to the laterality of cerebral functions and it's relation towards peripheral laterality gives the impression that this problem is precisely determined to a greater extent. The fact that can be accepted by the examination of literature is that the relation behavior (in the sense of acting)--brain (in the sense of a material determination of behavior itself) cannot be accepted as precisely determined or according to definition, not by nature nor by the mechanism of establishing this relation. From the perspective of the clinical viewpoint of the meaning of left-handedness the most acceptable is the theory of Satz Orsini and Sopper from 1986 in which they consider that non-righthanded people present a heterogenous group with a few individual sub-types: pathological lefthanded persons; ambivalent persons, in other words, ambidexters and the group of lefthanded persons by nature. On the basis of present neuropsychological research and in accordance with the psycho-neuro-vegetative approach to the semiotics of the developmental age of Popov et al., a complete battery is given which enables the neuropsychological analysis according to Orzbut's principals.

  19. Summary of Methods for Calculating Dynamic Lateral Stability and Response and for Estimating Lateral Stability Derivatives

    NASA Technical Reports Server (NTRS)

    Campbell, John P; Mckinney, Marion O

    1951-01-01

    A summary of methods for making dynamic lateral stability and response calculations and for estimating the aerodynamic stability derivatives required for use in these calculations is presented. The processes of performing calculations of the time histories of lateral motions, of the period and damping of these motions, and of the lateral stability boundaries are presented as a series of simple straightforward steps. Existing methods for estimating the stability derivatives are summarized and, in some cases, simple new empirical formulas are presented. Reference is also made to reports presenting experimental data that should be useful in making estimates of the derivatives. Detailed estimating methods are presented for low-subsonic-speed conditions but only a brief discussion and a list of references are given for transonic- and supersonic-speed conditions.

  20. Revisiting cognitive rehearsal as an intervention against incivility and lateral violence in nursing: 10 years later.

    PubMed

    Griffin, Martha; Clark, Cynthia M

    2014-12-01

    Ten years ago, Griffin wrote an article on the use of cognitive rehearsal as a shield for lateral violence. Since then, cognitive rehearsal has been used successfully in several studies as an evidence-based strategy to address uncivil and bullying behaviors in nursing. In the original study, 26 newly licensed nurses learned about lateral violence and used cognitive rehearsal techniques as an intervention for nurse-to-nurse incivility. The newly licensed nurses described using the rehearsed strategies as difficult, yet successful in reducing or eliminating incivility and lateral violence. This article updates the literature on cognitive rehearsal and reviews the use of cognitive rehearsal as an evidence-based strategy to address incivility and bullvina behaviors in nursing. PMID:25406637

  1. Macroscopic lateral heterogeneity observed in a laterally mobile immiscible mixed polyelectrolyte-neutral polymer brush

    SciTech Connect

    Lee, Hoyoung; Tsouris, Vasilios; Lim, Yunho; Mustafa, Rafid; Choi, Je; Choi, Yun Hwa; Park, Hae-Woong; Meron, Mati; Lin, Binhua; Won, You-Yeon

    2014-07-11

    We studied mixed poly(ethylene oxide) (PEO) and poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) brushes. The question we attempted to answer was: when the chain grafting points are laterally mobile, how will this lateral mobility influence the structure and phase behavior of the mixed brush? Three different model mixed PEO/PDMAEMA brush systems were prepared: (1) a laterally mobile mixed brush by spreading onto the air–water interface a mixture of poly(ethylene oxide)–poly(n-butyl acrylate) (PEO–PnBA) and poly(2-(dimethylamino)ethyl methacrylate)–poly(n-butyl acrylate) (PDMAEMA–PnBA) diblock copolymers (the specific diblock copolymers used will be denoted as PEO113–PnBA100 and PDMAEMA118–PnBA100, where the subscripts refer to the number-average degrees of polymerization of the individual blocks), (2) a mobility-restricted (inseparable) version of the above mixed brush prepared using a PEO–PnBA–PDMAEMA triblock copolymer (denoted as PEO113–PnBA89–PDMAEMA120) having respective brush molecular weights matched with those of the diblock copolymers, and (3) a different laterally mobile mixed PEO and PDMAEMA brush prepared from a PEO113–PnBA100 and PDMAEMA200–PnBA103 diblock copolymer combination, which represents a further more height-mismatched mixed brush situation than described in (1). These three mixed brush systems were investigated by surface pressure–area isotherm and X-ray (XR) reflectivity measurements. These experimental data were analyzed within the theoretical framework of a continuum self-consistent field (SCF) polymer brush model. The combined experimental and theoretical results suggest that the mobile mixed brush derived using the PEO113–PnBA100 and PDMAEMA118–PnBA100 combination (i.e., mixed brush System #1) undergoes a lateral macroscopic phase separation

  2. Lateral Quantum Dots for Quantum Information Processing

    NASA Astrophysics Data System (ADS)

    House, Matthew Gregory

    The possibility of building a computer that takes advantage of the most subtle nature of quantum physics has been driving a lot of research in atomic and solid state physics for some time. It is still not clear what physical system or systems can be used for this purpose. One possibility that has been attracting significant attention from researchers is to use the spin state of an electron confined in a semiconductor quantum dot. The electron spin is magnetic in nature, so it naturally is well isolated from electrical fluctuations that can a loss of quantum coherence. It can also be manipulated electrically, by taking advantage of the exchange interaction. In this work we describe several experiments we have done to study the electron spin properties of lateral quantum dots. We have developed lateral quantum dot devices based on the silicon metal-oxide-semiconductor transistor, and studied the physics of electrons confined in these quantum dots. We measured the electron spin excited state lifetime, which was found to be as long as 30 ms at the lowest magnetic fields that we could measure. We fabricated and characterized a silicon double quantum dot. Using this double quantum dot design, we fabricated devices which combined a silicon double quantum dot with a superconducting microwave resonator. The microwave resonator was found to be sensitive to two-dimensional electrons in the transistor channel, which we measured and characterized. We developed a new method for extracting information from random telegraph signals, which are produced when we observe thermal fluctuations of electrons in quantum dots. The new statistical method, based on the hidden Markov model, allows us to detect spin-dependent effects in such fluctuations even though we are not able to directly observe the electron spin. We use this analysis technique on data from two experiments involving gallium arsenide quantum dots and use it to measure spin-dependent tunneling rates. Our results advance the

  3. EAS-BUAP: Lateral Distribution and Performance

    NASA Astrophysics Data System (ADS)

    Salazar, H.; Martinez, O.; Cotzomi, J.; Moreno, E.; Aguilar, S.; Villaseñor, L.

    2003-07-01

    We describe the operation and performance of the first stage of the EAS-UAP extensive air shower array, as a detector of very high energy cosmic rays (Eo > 1014eV) after one year of operation. The array is located at the Campus of Puebla University, 2200 m above sea level. It consists of 10 liquid scintillator detectors, each with an active surface of 1 m2 and a detector spacing of 20 m in a square grid. One Auger Water Cherenkov detector is also included as part of the array. In this report we discuss the stability, the calibration and lateral distribution function reconstruction capabilities of the detector array. We also present the analysis of the shower size spectrum. In addition, the main characteristics of this array allow us to use it as an educational and training facility.

  4. Hyperimmune goat serum for amyotrophic lateral sclerosis.

    PubMed

    Mackenzie, R; Kiernan, M; McKenzie, D; Youl, B D

    2006-12-01

    The authors report a patient with amyotrophic lateral sclerosis (ALS) who showed a lessening of deterioration in respiratory muscle strength during treatment with hyperimmune goat serum (HGS) (Aimspro). Respiratory function tests (RFTs) were measured by established protocols, and all measurements were expressed as a percentage of normal predicted values. The rate of decline was calculated by linear regression analysis. Respiratory muscle strength decline was less during 13 months of treatment with HGS (mean 1.3% per month, range 0.8-1.7%) compared to the preceding 13 months (mean 2.3% per month, range 1.2-3.1%), while a greater decline would be expected with disease progression. Comparison with similarly affected patients in the literature suggest that a decline of 4-5% per month of predicted values may be expected during the treatment phase.

  5. Lateral hypothalamic circuits for feeding and reward.

    PubMed

    Stuber, Garret D; Wise, Roy A

    2016-02-01

    In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in well-fed animals. In the absence of food, animals will work tirelessly, often lever-pressing thousands of times per hour, for electrical stimulation at the same site that provokes feeding, drinking and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has used contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding-specific circuits. PMID:26814589

  6. A rare cause of lateral facial swelling.

    PubMed

    Mohanty, Sujata; Gulati, Ujjwal; Vandana; Singh, Sapna

    2014-01-01

    A case of chronic, recurrent and asymptomatic facial swelling in a young male is presented. Swelling extended from lower midface to upper lateral neck and right commissure to anterior massetric border. History, clinical signs and symptoms and examination pointed towards the benign nature of the swelling. Fine-needle aspiration cytology tapered the diagnostic possibilities to a salivary cyst or pseudocyst. Ultrasonography identified the lesion to contain echogenic fluid with irregular borders. "Tail sign" was absent on contrast magnetic resonance imaging, excluding the involvement of the sublingual gland. Surgical excision of the lesion was done along with submandibular gland as both were in continuity via a bottle-neck tract. Final histopathological diagnosis was that of the submandibular gland extravasation phenomenon. As per the best of our knowledge, it is the first case report of a submandibular gland extravasation causing swelling in a retrograde direction onto the face. PMID:25593883

  7. Exchange coupling between laterally adjacent nanomagnets

    NASA Astrophysics Data System (ADS)

    Dey, H.; Csaba, G.; Bernstein, G. H.; Porod, W.

    2016-09-01

    We experimentally demonstrate exchange-coupling between laterally adjacent nanomagnets. Our results show that two neighboring nanomagnets that are each antiferromagnetically exchange-coupled to a common ferromagnetic bottom layer can be brought into strong ferromagnetic interaction. Simulations show that interlayer exchange coupling effectively promotes ferromagnetic alignment between the two nanomagnets, as opposed to antiferromagnetic alignment due to dipole-coupling. In order to experimentally demonstrate the proposed scheme, we fabricated arrays of pairs of elongated, single-domain nanomagnets. Magnetic force microscopy measurements show that most of the pairs are ferromagnetically ordered. The results are in agreement with micromagnetic simulations. The presented scheme can achieve coupling strengths that are significantly stronger than dipole coupling, potentially enabling far-reaching applications in Nanomagnet Logic, spin-wave devices and three-dimensional storage and computing.

  8. Lateral Hypothalamic Circuits for Feeding and Reward

    PubMed Central

    Stuber, Garret D.; Wise, Roy A.

    2016-01-01

    In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in non-restricted animals. In the absence of food, animals will work tirelessly, often lever-pressing 1000’s of times per hour, for electrical stimulation at the same site that provokes feeding, drinking, and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has utilized contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala, and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding specific circuits. PMID:26814589

  9. Optical fiber head for providing lateral viewing

    DOEpatents

    Everett, Matthew J.; Colston, Billy W.; James, Dale L.; Brown, Steve; Da Silva, Luiz

    2002-01-01

    The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle .theta.. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle .theta. must be no greater than 39.degree. or must be at least 51.degree.. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.

  10. Large-scale lateral nanowire arrays nanogenerators

    DOEpatents

    Wang, Zhong L; Xu, Chen; Qin, Yong; Zhu, Guang; Yang, Rusen; Hu, Youfan; Zhang, Yan

    2014-01-07

    In a method of making a generating device, a plurality of spaced apart elongated seen members are deposited onto a surface of a flexible non-conductive substrate. An elongated conductive layer is applied to a top surface and a first side of each seed member, thereby leaving an exposed second side opposite the first side. A plurality of elongated piezoelectric nanostructures is grown laterally from the second side of each seed layer. A second conductive material is deposited onto the substrate adjacent each elongated first conductive layer so as to be soupled the distal end of each of the plurality of elongated piezoelectric nanostructures. The second conductive material is selected so as to form a Schottky barrier between the second conductive material and the distal end of each of the plurality of elongated piezoelectric nanostructures and so as to form an electrical contact with the first conductive layer.

  11. Electrodiagnosis in persons with amyotrophic lateral sclerosis.

    PubMed

    Joyce, Nanette C; Carter, Gregory T

    2013-05-01

    Electrophysiology remains an important tool in the evaluation of patients presenting with signs and symptoms of motor neuron disease. The electrodiagnostic study should include peripheral nerve conduction studies and needle electromyography to both exclude treatable disease and gather evidence regarding a diagnosis of amyotrophic lateral sclerosis (ALS). The recent changes in the revised El Escorial criteria, recommended by the Awaji-shima consensus group, have increased the diagnostic significance of fasciculation potentials to equal that of fibrillation and positive sharp-wave potentials in the needle electromyography examination of patients suspected of having ALS. In addition, electrophysiologic evidence is now considered equivalent to clinical signs and symptoms in reaching a diagnostic certainty of ALS. These changes, strategies for the design, and implementation of an effective electrodiagnostic evaluation, in addition to electrophysiologic techniques and their relationship to the evaluation of a patient with ALS, are reviewed and discussed.

  12. On lateral competition in dynamic neural networks

    SciTech Connect

    Bellyustin, N.S.

    1995-02-01

    Artificial neural networks connected homogeneously, which use retinal image processing methods, are considered. We point out that there are probably two different types of lateral inhibition for each neural element by the neighboring ones-due to the negative connection coefficients between elements and due to the decreasing neuron`s response to a too high input signal. The first case characterized by stable dynamics, which is given by the Lyapunov function, while in the second case, stability is absent and two-dimensional dynamic chaos occurs if the time step in the integration of model equations is large enough. The continuous neural medium approximation is used for analytical estimation in both cases. The result is the partition of the parameter space into domains with qualitatively different dynamic modes. Computer simulations confirm the estimates and show that joining two-dimensional chaos with symmetries provided by the initial and boundary conditions may produce patterns which are genuine pieces of art.

  13. Young victims and their later partners.

    PubMed

    Wageningen, A

    1989-01-01

    Sexual abuse can seriously traumatize the victim, especially if she is a young girl Ambivalent feelings regarding herself and others make it difficult and often impossible for her to find a partner later. Most relationships are brief. If the victim is able to form a lasting relationship both she and her partner will be confronted with the effects of her trauma. They face relational and sexual problems. It is difficult for the partner to accept her trauma emotionally. Therapy, usually carried out individually or in groups and without the partner, often fails to prevent the breakdown of their relationship or marriage. The partner's presence in or involvement with the treatment has proved very helpful provided the relationship has possibilities for change. PMID:2516591

  14. Motoneuron firing in amyotrophic lateral sclerosis (ALS)

    PubMed Central

    de Carvalho, Mamede; Eisen, Andrew; Krieger, Charles; Swash, Michael

    2014-01-01

    Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia. The physiological disturbance consequent on the motor system degeneration is beginning to be well understood. In this review we describe aspects of the motor cortical, neuronal, and lower motor neuron dysfunction. We show how studies of the changes in the pattern of motor unit firing help delineate the underlying pathophysiological disturbance as the disease progresses. Such studies are beginning to illuminate the underlying disordered pathophysiological processes in the disease, and are important in designing new approaches to therapy and especially for clinical trials. PMID:25294995

  15. A rare cause of lateral facial swelling

    PubMed Central

    Mohanty, Sujata; Gulati, Ujjwal; Vandana; Singh, Sapna

    2014-01-01

    A case of chronic, recurrent and asymptomatic facial swelling in a young male is presented. Swelling extended from lower midface to upper lateral neck and right commissure to anterior massetric border. History, clinical signs and symptoms and examination pointed towards the benign nature of the swelling. Fine-needle aspiration cytology tapered the diagnostic possibilities to a salivary cyst or pseudocyst. Ultrasonography identified the lesion to contain echogenic fluid with irregular borders. “Tail sign” was absent on contrast magnetic resonance imaging, excluding the involvement of the sublingual gland. Surgical excision of the lesion was done along with submandibular gland as both were in continuity via a bottle-neck tract. Final histopathological diagnosis was that of the submandibular gland extravasation phenomenon. As per the best of our knowledge, it is the first case report of a submandibular gland extravasation causing swelling in a retrograde direction onto the face. PMID:25593883

  16. A comprehensive review of amyotrophic lateral sclerosis

    PubMed Central

    Zarei, Sara; Carr, Karen; Reiley, Luz; Diaz, Kelvin; Guerra, Orleiquis; Altamirano, Pablo Fernandez; Pagani, Wilfredo; Lodin, Daud; Orozco, Gloria; Chinea, Angel

    2015-01-01

    Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5–10% of the cases are familial ALS. Both sporadic and familial ALS (FALS) are associated with degeneration of cortical and spinal motor neurons. The etiology of ALS remains unknown. However, mutations of superoxide dismutase 1 have been known as the most common cause of FALS. In this study, we provide a comprehensive review of ALS. We cover all aspects of the disease including epidemiology, comorbidities, environmental risk factor, molecular mechanism, genetic factors, symptoms, diagnostic, treatment, and even the available supplement and management of ALS. This will provide the reader with an advantage of receiving a broad range of information about the disease. PMID:26629397

  17. Analysis of flexible structures under lateral impact

    SciTech Connect

    Ramirez, D. F.; Razavi, H.

    2012-07-01

    Three methods for analysis of flexible structures under lateral impact are presented. The first proposed method (Method A) consists of: (1) modifying an available deceleration on a rigid target with conservation principles to account for structural flexibility; and (2) transient nonlinear analysis of the structure with the corrected forcing function. The second proposed method (Method B) is similar to Method A in obtaining the forcing function but it solves the equations of motion of an idealized two-degree-of-freedom system instead of directly using conservation principles. The last method simply provides the maximum force in the structure using the conservation of energy and linear momentum. A coupled simulation is also performed in LS-DYNA and compared against the proposed methods. A case study is presented to illustrate the applicability of all three methods and the LS-DYNA simulation. (authors)

  18. Amyotrophic lateral sclerosis and environmental factors

    PubMed Central

    Bozzoni, Virginia; Pansarasa, Orietta; Diamanti, Luca; Nosari, Guido; Cereda, Cristina; Ceroni, Mauro

    2016-01-01

    Summary Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central and peripheral motor neuron cells. Its etiology is unknown, although a relationship between genetic background and environmental factors may play a major role in triggering the neurodegeneration. In this review, we analyze the role of environmental factors in ALS: heavy metals, electromagnetic fields and electric shocks, pesticides, β-N-methylamino-L-alanine, physical activity and the controversial role of sports. The literature on the single issues is analyzed in an attempt to clarify, as clearly as possible, whether each risk factor significantly contributes to the disease pathogenesis. After summarizing conflicting observations and data, the authors provide a final synthetic statement. PMID:27027889

  19. The 'Omics' of Amyotrophic Lateral Sclerosis.

    PubMed

    Caballero-Hernandez, Diana; Toscano, Miguel G; Cejudo-Guillen, Marta; Garcia-Martin, Maria L; Lopez, Soledad; Franco, Jaime M; Quintana, Francisco J; Roodveldt, Cintia; Pozo, David

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that primarily affects motor neurons and is accompanied by sustained unregulated immune responses, but without clear indications of the ultimate causative mechanisms. The identification of a diverse array of ALS phenotypes, a series of recently discovered mutations, and the links between ALS and frontotemporal degeneration have significantly increased our knowledge of the disease. In this review we discuss the main features involved in ALS pathophysiology in the context of recent advances in 'omics' approaches, including genomics, proteomics, and others. We emphasize the pressing need to combine clinical imaging with various different parameters taken from omics fields to facilitate early, accurate diagnosis and rational drug design in the treatment of ALS.

  20. Toward precision medicine in amyotrophic lateral sclerosis

    PubMed Central

    Liu, Chang-Yun; Che, Chun-Hui

    2016-01-01

    Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual’s disease. This approach is only just beginning to be considered for treating amyotrophic lateral sclerosis (ALS). The clinical and biological complexities of ALS have hindered development of effective therapeutic strategies. In this review we consider applying the key elements of precision medicine to ALS: phenotypic classification, comprehensive risk assessment, presymptomatic period detection, potential molecular pathways, disease model development, biomarker discovery and molecularly tailored interventions. Together, these would embody a precision medicine approach, which may provide strategies for optimal targeting and timing of efforts to prevent, stop or slow progression of ALS. PMID:26889480

  1. Magnetic resonance imaging in amyotrophic lateral sclerosis.

    PubMed

    Kollewe, Katja; Körner, Sonja; Dengler, Reinhard; Petri, Susanne; Mohammadi, Bahram

    2012-01-01

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder which is incurable to date. As there are many ongoing studies with therapeutic candidates, it is of major interest to develop biomarkers not only to facilitate early diagnosis but also as a monitoring tool to predict disease progression and to enable correct randomization of patients in clinical trials. Magnetic resonance imaging (MRI) has made substantial progress over the last three decades and is a practical, noninvasive method to gain insights into the pathology of the disease. Disease-specific MRI changes therefore represent potential biomarkers for ALS. In this paper we give an overview of structural and functional MRI alterations in ALS with the focus on task-free resting-state investigations to detect cortical network failures. PMID:22848820

  2. Early Pavlovian conditioning impairs later Pavlovian conditioning.

    PubMed

    Lariviere, N A; Spear, N E

    1996-11-01

    Four experiments tested the effects in the rat of very early experience with stimuli to be used later for Pavlovian conditioning. Beginning on postnatal Day 12, prior to the development of substantial detection and effective perception of visual and auditory stimuli, rats were given five daily experiences with either lights or tones and a footshock known to be an effective unconditioned stimulus at these ages. Twenty-four hours after the last of these experiences, pairings of either the light or tone and the unconditioned stimulus were given with parameters established to yield a moderate degree of conditioning in untreated preweanlings (Experiment 1). Experiment 2 determined that early experience with paired or unpaired presentations of either the light or tone and the unconditioned stimulus resulted in a failure to condition to these same lights or tones on postnatal Day 17, although nontreated pups from the same litters conditioned quite effectively. Experiment 3 determined that this early conditioning experience with either paired or unpaired presentations of the lights or tones and the unconditioned stimulus yielded impaired conditioning on postnatal Day 17 in the alternative sensory modality as well, although again nontreated siblings conditioned quite effectively. Experiment 4 replicated the results of each of Experiments 2 and 3 and determined in addition that despite the impairment in conditioning that resulted from early paired or unpaired experience with the stimuli of conditioning, early experience with the individual stimuli of conditioning-with only the CS, the US, or the context-did not result in a similar impairment in conditioning. Although the results were unexpected, they may be understood in part in terms of intersensory competition during development, and there is precedent in the literature for similar interfering effects of early learning on later learning in a variety of species.

  3. Lateral interactions in the outer retina

    PubMed Central

    Thoreson, Wallace B.; Mangel, Stuart C.

    2012-01-01

    Lateral interactions in the outer retina, particularly negative feedback from horizontal cells to cones and direct feed-forward input from horizontal cells to bipolar cells, play a number of important roles in early visual processing, such as generating center-surround receptive fields that enhance spatial discrimination. These circuits may also contribute to post-receptoral light adaptation and the generation of color opponency. In this review, we examine the contributions of horizontal cell feedback and feed-forward pathways to early visual processing. We begin by reviewing the properties of bipolar cell receptive fields, especially with respect to modulation of the bipolar receptive field surround by the ambient light level and to the contribution of horizontal cells to the surround. We then review evidence for and against three proposed mechanisms for negative feedback from horizontal cells to cones: 1) GABA release by horizontal cells, 2) ephaptic modulation of the cone pedicle membrane potential generated by currents flowing through hemigap junctions in horizontal cell dendrites, and 3) modulation of cone calcium currents (ICa) by changes in synaptic cleft proton levels. We also consider evidence for the presence of direct horizontal cell feed-forward input to bipolar cells and discuss a possible role for GABA at this synapse. We summarize proposed functions of horizontal cell feedback and feed-forward pathways. Finally, we examine the mechanisms and functions of two other forms of lateral interaction in the outer retina: negative feedback from horizontal cells to rods and positive feedback from horizontal cells to cones. PMID:22580106

  4. Costa Rica's Chain of laterally collapsed volcanoes.

    NASA Astrophysics Data System (ADS)

    Duarte, E.; Fernandez, E.

    2007-05-01

    From the NW extreme to the SW end of Costa Rica's volcanic backbone, a number of laterally collapsed volcanoes can be observed. Due to several factors, attention has been given to active volcanoes disregarding the importance of collapsed features in terms of assessing volcanic hazards for future generations around inhabited volcanoes. In several cases the typical horseshoe shape amphitheater-like depression can be easily observed. In other cases due to erosion, vegetation, topography, seismic activity or drastic weather such characteristics are not easily recognized. In the order mentioned above appear: Orosi-Cacao, Miravalles, Platanar, Congo, Von Frantzius, Cacho Negro and Turrialba volcanoes. Due to limited studies on these structures it is unknown if sector collapse occurred in one or several phases. Furthermore, in the few studied cases no evidence has been found to relate collapses to actual eruptive episodes. Detailed studies on the deposits and materials composing dome-like shapes will shed light on unsolved questions about petrological and chemical composition. Volume, form and distance traveled by deposits are part of the questions surrounding most of these collapsed volcanoes. Although most of these mentioned structures are extinct, at least Irazú volcano (active volcano) has faced partial lateral collapses recently. It did presented strombolian activity in the early 60s. Collapse scars show on the NW flank show important mass removal in historic and prehistoric times. Moreover, in 1994 a minor hydrothermal explosion provoked the weakening of a deeply altered wall that holds a crater lake (150m diameter, 2.6x106 ). A poster will depict images of the collapsed volcanoes named above with mayor descriptive characteristics. It will also focus on the importance of deeper studies to assess the collapse potential of Irazú volcano with related consequences. Finally, this initiative will invite researchers interested in such topic to join future studies in

  5. Coverage of Exposed Bone of the Lateral Malleolus With a Proximally Based Lateral Malleolar Perforator Flap.

    PubMed

    van der Zee, Caroline W; Moerman, Esther; Haverlag, Robert; Schepers, Tim

    2015-01-01

    The treatment of soft tissue defects of the ankle, combined with an implant-related infection, remains a challenge. The present case report illustrates the use of a pedicled perforator flap for soft tissue reconstruction to cover a postoperative defect at the lateral malleolus after an ankle fracture. PMID:25154652

  6. Lateral lower leg perforator flaps: an anatomical study to localize and classify lateral lower leg perforators.

    PubMed

    Hupkens, Pieter; Schijns, Wendy; Van Abeelen, Marjolijn; Kooloos, Jan G M; Slater, Nicholas J; Ulrich, Dietmar J O

    2015-02-01

    Despite increasing use of lateral lower leg perforator flaps, comprehensive anatomical data are still lacking. The aim of this article was to comprehensively document the pattern of usable lateral lower leg perforators. Systematic mapping of 16 cadaver leg perforators in a well-defined area was performed to elucidate location, course, length, diameter, and origin. Overall, 197 perforators were found in 16 lateral lower legs. The mean number of perforators per leg with a diameter ≥ 0.3 mm was 13.4 ± 3.6. Most perforators were found in the distal third (39.0%), followed by the middle third (32.0%), and proximal third (29.0%). A musculocutaneous course was found in 26.9% of the perforators, whereas 73.1% revealed a septocutaneous course. Most septocutaneous perforators (50.0%) were found in the distal third and most musculocutaneous perforators (58.5%) in the proximal third (P < 0.001). The majority of perforators originated from the anterior tibial artery (53.0%), followed by the peroneal artery (41.6%), and the popliteal artery (5.1%). Popliteal artery perforators (1.64 mm) were significantly larger than anterior tibial artery (0.91 mm) and peroneal artery perforators (1.02 mm; P < 0.001). These results may facilitate tissue transfer around the lateral lower leg.

  7. Diagnosis and Treatment of Lateral Patellar Compression Syndrome

    PubMed Central

    Saper, Michael G.; Shneider, David A.

    2014-01-01

    Chronic anterior knee pain with a stable patella is often associated with overload and increased pressure on the lateral facet due to pathologic lateral soft-tissue restraints. “Lateral pressure in flexion” is a term describing the pathologic process of increasing contact pressure over the lateral patellar facet as knee flexion progresses. This report describes a surgical technique developed in response to lateral pressure in flexion and the shortcomings of traditional arthroscopic lateral release procedures. The technique is performed open with the knee in flexion, and the lateral release is repaired with a rotation flap of iliotibial band to close the defect and prevent patellar subluxation. The technique effectively decreases lateral patellar pressure and centers the patella correctly in the trochlear groove with minimal risk of iatrogenic patellar instability. PMID:25473620

  8. Variable left-hemisphere language and orthographic lateralization reduces right-hemisphere face lateralization.

    PubMed

    Dundas, Eva M; Plaut, David C; Behrmann, Marlene

    2015-05-01

    It is commonly believed that, in right-handed individuals, words and faces are processed by distinct neural systems: one in the left hemisphere (LH) for words and the other in the right hemisphere (RH) for faces. Emerging evidence suggests, however, that hemispheric selectivity for words and for faces may not be independent of each other. One recent account suggests that words become lateralized to the LH to interact more effectively with language regions, and subsequently, as a result of competition with words for representational space, faces become lateralized to the RH. On this interactive account, left-handed individuals, who as a group show greater variability with respect to hemispheric language dominance, might be expected to show greater variability in their degree of RH lateralization of faces as well. The current study uses behavioral measures and ERPs to compare the hemispheric specialization for both words and faces in right- and left-handed adult individuals. Although both right- and left-handed groups demonstrated LH over RH superiority in discrimination accuracy for words, only the right-handed group demonstrated RH over LH advantage in discrimination accuracy for faces. Consistent with this, increased right-handedness was related to an increase in RH superiority for face processing, as measured by the strength of the N170 ERP component. Interestingly, the degree of RH behavioral superiority for face processing and the amplitude of the RH N170 for faces could be predicted by the magnitude of the N170 ERP response to words in the LH. These results are discussed in terms of a theoretical account in which the typical RH face lateralization fails to emerge in individuals with atypical language lateralization because of weakened competition from the LH representation of words.

  9. Lateral bias, functional asymmetry, dance training and dance injuries.

    PubMed

    Kimmerle, Marliese

    2010-01-01

    The purpose of this article is to: 1. provide a conceptual framework for consolidating laterality research in dance training from an interdisciplinary perspective; 2. encourage the reporting of lateral data; 3. promote the development of standardized methods for assessing lateral preference and functional asymmetry so that data sets from student screenings, lab studies, and injury reports can be compared; and 4. stimulate further laterality research in the dance studio to examine student preference and teaching bias, thereby promoting balanced training.

  10. Predicting Later-Life Outcomes of Early-Life Exposures

    EPA Science Inventory

    Background: In utero exposure of the fetus to a stressor can lead to disease in later life. Epigenetic mechanisms are likely mediators of later-life expression of early-life events.Objectives: We examined the current state of understanding of later-life diseases resulting from ea...

  11. Sex Differences in Cerebral Laterality of Language and Visuospatial Processing

    ERIC Educational Resources Information Center

    Clements, A. M.; Rimrodt, S. L.; Abel, J. R.; Blankner, J. G.; Mostofsky, S. H.; Pekar, J. J.; Denckla, M. B.; Cutting, L. E.

    2006-01-01

    Sex differences on language and visuospatial tasks are of great interest, with differences in hemispheric laterality hypothesized to exist between males and females. Some functional imaging studies examining sex differences have shown that males are more left lateralized on language tasks and females are more right lateralized on visuospatial…

  12. Diageotropica and lateral rooting, the rest of the story

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The nature of the control of lateral root initiation has been controversial for 80+ years. A mutant tomato (diageotropica), incapable of producing lateral roots, was first classified as ethylene requiring since exceptionally low concentrations of ethylene, applied to the shoot, stimulated lateral r...

  13. In situ hydrodynamic lateral force calibration of AFM colloidal probes.

    PubMed

    Ryu, Sangjin; Franck, Christian

    2011-11-01

    Lateral force microscopy (LFM) is an application of atomic force microscopy (AFM) to sense lateral forces applied to the AFM probe tip. Recent advances in tissue engineering and functional biomaterials have shown a need for the surface characterization of their material and biochemical properties under the application of lateral forces. LFM equipped with colloidal probes of well-defined tip geometries has been a natural fit to address these needs but has remained limited to provide primarily qualitative results. For quantitative measurements, LFM requires the successful determination of the lateral force or torque conversion factor of the probe. Usually, force calibration results obtained in air are used for force measurements in liquids, but refractive index differences between air and liquids induce changes in the conversion factor. Furthermore, in the case of biochemically functionalized tips, damage can occur during calibration because tip-surface contact is inevitable in most calibration methods. Therefore, a nondestructive in situ lateral force calibration is desirable for LFM applications in liquids. Here we present an in situ hydrodynamic lateral force calibration method for AFM colloidal probes. In this method, the laterally scanned substrate surface generated a creeping Couette flow, which deformed the probe under torsion. The spherical geometry of the tip enabled the calculation of tip drag forces, and the lateral torque conversion factor was calibrated from the lateral voltage change and estimated torque. Comparisons with lateral force calibrations performed in air show that the hydrodynamic lateral force calibration method enables quantitative lateral force measurements in liquid using colloidal probes.

  14. Lateral transport of phosphorus along forested hillslopes

    NASA Astrophysics Data System (ADS)

    Sohrt, Jakob; Weiler, Markus; Puhlmann, Heike

    2016-04-01

    Details about the phosphorus (P)-cycle in temperate forests are still incomplete, though there are indications that the organic topsoil acts as an important source and sink for P. It can act as a sink for P in fallen litter and as a source since the decaying biomass replenishes the pool of inorganic, water soluble and thus plant available P. The aim of this study was to determine the magnitude of lateral mobilization, transport and retention of total P (persulfate digestion method) in the soil at various depths of a broadleaf forest during heavy rainstorm events. On three locations in Germany, 10 m long and over 3m deep trenches were constructed to collect lateral subsurface flow from three discrete depth-layers between the soil surface and a depth of three meters. Sampling is handled through an automated system which collects flow-proportional samples in high temporal resolution. Sampling took place from March to November 2015 including more than 20 rainfall runoff events. Simultaneously to the sampling, flow rate, conductivity and temperature of the interflow was measured as well as soil moisture, rainfall and discharge in the nearest downslope spring. The results show consistently that P-concentrations in interflow samples are highest at the beginning of a rainfall-interflow-event, both for wet and dry initial conditions, and drop considerably over the course of the event until they stabilize. Secondly, P-concentration of interflow samples is by far highest in the organic topsoil, being up to one magnitude higher that in the mineral soil directly below and decreasing further with depth. This pattern applies despite the fact that there is very little temporal delay between the activation of interflow in the topsoil and deeper layers which indicates that at least some of the interflow in the topsoil ends up as interflow in deeper layers within a short time span. These results indicate that the organic topsoil contains a pool of P that is easily mobilized and

  15. Dynamic cortical lateralization during olfactory discrimination learning

    PubMed Central

    Cohen, Yaniv; Putrino, David; Wilson, Donald A

    2015-01-01

    Key points Odour discrimination and memory involve changes in the primary olfactory (piriform) cortex. The results obtained in the present study suggest that there is an asymmetry in piriform cortical change, with learning-related changes in cortical oscillations emerging with different time courses over the course of multiday training in the left and right piriform cortices in rats. There is an initial decrease in coherence between the left and right piriform cortices during the early stages of the odour discrimination task, which recovers as the animals approach criterion performance. This decreased coherence is expressed when the animals are performing the task relative to when they are in their home cage. The results suggest a transient cortical asymmetry during learning and raise new questions about the functions and mechanisms of cerebral lateralization. Abstract Bilateral cortical circuits are not necessarily symmetrical. Asymmetry, or cerebral lateralization, allows functional specialization of bilateral brain regions and has been described in humans for such diverse functions as perception, memory and emotion. There is also evidence for asymmetry in the human olfactory system, although evidence in non-human animal models is lacking. In the present study, we took advantage of the known changes in olfactory cortical local field potentials that occur over the course of odour discrimination training to test for functional asymmetry in piriform cortical activity during learning. Both right and left piriform cortex local field potential activities were recorded. The results obtained demonstrate a robust interhemispheric asymmetry in anterior piriform cortex activity that emerges during specific stages of odour discrimination learning, with a transient bias toward the left hemisphere. This asymmetry is not apparent during error trials. Furthermore, functional connectivity (coherence) between the bilateral anterior piriform cortices is learning- and context

  16. Laryngomalacia and inspiratory obstruction in later childhood.

    PubMed Central

    Smith, G J; Cooper, D M

    1981-01-01

    Pulmonary function and symptoms were reviewed in 20 children in whom laryngomalacia had been diagnosed by direct laryngoscopy in infancy. Most children developed stridor in the first 2 weeks, but 3 children did not develop it until age 3 months. The mean duration of stridor was 4 years 2 months, with a range of 4 months to 12 years 7 months. Six children had marked posseting as infants. Airway dynamics were assessed by flow volume loops. All except one had normal expiratory flow volume curves. Inspiratory abnormalities were detected in 7 children; 6 were assessed as having variable extrathoracic inspiratory obstructions and 1 had a fixed obstruction consistent with subglottic stenosis. The mean ratios of maximal inspiratory flow at 50% of vital capacity divided by forced vital capacity in the laryngomalacia and control groups differed significantly, as did the mean ratios of maximal expiratory flow to maximal inspiratory flow at 50% of forced vital capacity. Laryngomalacia is not necessarily a benign disorder of limited duration; there may be persisting inspiratory obstruction in later childhood. PMID:7259255

  17. Acupuncture for Lateral Epicondylitis: A Systematic Review

    PubMed Central

    Tang, Hongzhi; Fan, Huaying; Chen, Jiao; Yang, Mingxiao; Yi, Xuebing; Dai, Guogang; Chen, Junrong; Tang, Liugang; Rong, Haibo; Wu, Junhua; Liang, Fanrong

    2015-01-01

    Objective. This systematic review aimed to assess the effectiveness and safety of acupuncture for lateral epicondylitis (LE). Methods. Seven databases and the WHO International Clinical Trials Registry Platform Search Portal were searched to identify relevant studies. The data were extracted and assessed by two independent authors, and Review Manager Software (V.5.3) was used for data synthesis with effect estimate presented as standard mean difference (SMD) and mean difference (MD) with a 95% confidence interval. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the level of evidence. Results. Four RCTs with 309 participants were included with poor methodological quality. Participants who received acupuncture and acupuncture plus moxibustion with material insulation were likely to have an improvement in elbow functional status and/or myodynamia. The overall quality rated by GRADE was from very low to low. Two studies reported that the needle pain would be the main reason for the dropout. Conclusion. For the small number of included studies with poor methodological quality, no firm conclusion can be drawn regarding the effect of acupuncture of elbow functional status and myodynamia for LE. This trial is registered with CRD42015016199. PMID:26843886

  18. Impaired Cognitive Flexibility in Amyotrophic Lateral Sclerosis

    PubMed Central

    Evans, Jessica; Olm, Christopher; McCluskey, Leo; Elman, Lauren; Boller, Ashley; Moran, Eileen; Rascovsky, Katya; Bisbing, Teagan; McMillan, Corey T.; Grossman, Murray

    2014-01-01

    Objective Up to half of patients with amyotrophic lateral sclerosis (ALS) may have cognitive difficulty, but most cognitive measures are confounded by a motor component. Rare studies have related impaired cognition in ALS to disease in gray matter (GM) and white matter (WM). We evaluated a simple, untimed measure of executive functioning with minimal motor demands in ALS, and relate performance to structural disease. Methods Fifty-six patients with ALS and 29 matched healthy controls were assessed with the Visual-Verbal Test (VVT). This brief measure of cognitive flexibility first assesses an individual's ability to identify a shared feature in three of four simple geometric designs. Cognitive flexibility is challenged when individuals are next asked to identify a different shared feature in another three of the same four geometric designs. Regression analyses related performance to GM atrophy and reduced WM fractional anisotropy (FA) in a subset of patients. Results ALS patients were significantly impaired on this simple measure of cognitive flexibility (p<0.01). An error in cognitive flexibility was present in 48.2% of individual ALS patients. Regression analyses related impaired cognitive flexibility to GM atrophy in inferior frontal and insula regions, and to reduced FA in WM projections in inferior frontal-occipital and uncinate fasciculi and corpus callosum. Conclusion Patients with ALS have impaired cognitive flexibility on an untimed measure with minimal motor demands, and this is related in part to a large-scale frontal network that is degraded in ALS. PMID:25812127

  19. Characteristics of pain in amyotrophic lateral sclerosis

    PubMed Central

    Hanisch, Frank; Skudlarek, Anika; Berndt, Janine; Kornhuber, Malte E

    2015-01-01

    Background Pain is an often underestimated and neglected symptom in amyotrophic lateral sclerosis (ALS). Methods In a cross-sectional survey, 46 patients with ALS, 46 age- and gender matched population-based controls, and 23 diseased controls with myotonic dystrophy type 2 (DM2) were screened for occurrence, type, distribution, and treatment of pain and cramps. Data were collected with the use of the short form brief pain inventory (BPI). Results Pain was reported in 78% of ALS patients,79% of DM2 patients, and 54% of controls (P < 0.05). More ALS patients than controls reported moderate to severe pain (42% vs. 20%). Pain in ALS patients interfered significantly more with daily activities than in controls (median pain interference score: 3.0 vs. 1.2, P < 0.05), especially enjoyment of life (5.0 vs. 1.0) and mood (3.0 vs. 1.0). There was no correlation between the duration of the disease and the severity of pain. Movement-induced cramps were reported in 63% of ALS patients, mostly in the distal extremities. There was no difference in the duration of ALS disease between patients reporting cramps and those who did not. Discussion Our study showed that pain was a relatively frequent symptom which had an important impact on the quality of life. Pain that requires treatment can occur at every stage of ALS. PMID:25642388

  20. Impaired Sacculocollic Reflex in Lateral Medullary Infarction

    PubMed Central

    Kim, Seonhye; Kim, Hyo-Jung; Kim, Ji Soo

    2011-01-01

    Objective: The aim of this study was to determine saccular dysfunction by measuring cervical vestibular-evoked myogenic potentials (cVEMP) and to correlate abnormality of cVEMP with results of other vestibular function tests in lateral medullary infarction (LMI). Methods: We recorded cVEMP in 21 patients with LMI documented on MRI. cVEMP was induced by a short tone burst and was recorded in contracting sternocleidomastoid muscle while patients turned their heads forcefully to the contralateral side against resistance. Patients also underwent video-oculographic recording of spontaneous, gaze-evoked and head shaking nystagmus (HSN), evaluation of ocular tilt reaction (OTR), measurement of the subjective visual vertical (SVV) tilt, bithermal caloric tests, and audiometry. Results: Nine patients (43%) showed abnormal cVEMP, unilateral in seven and bilateral in two. The cVEMP abnormalities included decreased p13–n23 amplitude in four, delayed p13/n23 responses in five, and both decreased and delayed responses in two. The abnormal cVEMP was ipsilesional in five, contralesional in two, and bilateral in two. The prevalence of OTR/SVV tilt, spontaneous nystagmus, and HSN did not differ between the patients with normal and abnormal cVEMP. Conclusion: cVEMP was abnormal in approximately half of the patients with LMI. The abnormal cVEMP indicates damage to the descending sacculocollic reflex pathway or disruption of commissural modulation between the vestibular nuclei. PMID:21415908

  1. Narrative discourse deficits in amyotrophic lateral sclerosis

    PubMed Central

    Menaged, Anna; Olm, Christopher; McMillan, Corey T.; Boller, Ashley; Irwin, David J.; McCluskey, Leo; Elman, Lauren; Grossman, Murray

    2014-01-01

    Objective: We examined narrative discourse in amyotrophic lateral sclerosis (ALS) to assess the role of executive functioning in support of language and the neuroanatomical basis for such support. Methods: We analyzed a semistructured speech sample in 26 patients with ALS and 19 healthy seniors for narrative discourse features of coherence. Regression analyses related a measure of discourse coherence (“local connectedness”) to gray matter atrophy and reduced white matter fractional anisotropy. Results: Patients with ALS were impaired relative to controls on measures of discourse adequacy, including local connectedness and maintenance of the theme. These discourse measures were related to measures of executive functioning but not to motor functioning. Regressions related local connectedness to gray matter atrophy in ventral and dorsal prefrontal regions and to reduced fractional anisotropy in white matter tracts mediating projections between prefrontal regions. Conclusion: Patients with ALS exhibit deficits in their ability to organize narrative discourse. These deficits appear to be related in part to executive limitations. Consistent with the hypothesis that ALS is a multisystem disorder, this deficit is related to disease in prefrontal regions. PMID:24991038

  2. [Restorative therapy in amyotrophic lateral sclerosis].

    PubMed

    Aoki, Masashi

    2012-11-01

    Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disorder characterized by the death of upper and lower motor neurons. About 10% of all ALS cases are familial; approximately 20% of familial ALS cases are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed rats that express a human SOD1 transgene with ALS-associated mutations, developing striking motor neuron degeneration and paralysis. The larger size of this rat model as compared with the ALS mice, will facilitate studies involving manipulations of spinal fluid and the spinal cord. Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. We administered human recombinant HGF (hrHGF) by continuous intrathecal delivery to the transgenic rats at the onset of paralysis for 4 weeks. Intrathecal administration of hrHGF attenuated motor neuron degeneration and prolonged the duration of the disease by 63%. To translate this strategy to human treatment, we induced a contusive cervical spinal cord injury in the common marmoset, a primate, and then administered hrHGF intrathecally. The intrathecal administration of hrHGF promoted functional recovery. These results prompted further clinical trials in ALS using continuous intrathecal administration of hrHGF. PMID:23373317

  3. Possession Divestment by Sales in Later Life

    PubMed Central

    Ekerdt, David J.; Addington, Aislinn

    2015-01-01

    Residential relocation in later life is almost always a downsizing, with many possessions to be divested in a short period of time. This article examines older movers’ capacities for selling things, and ways that selling attenuates people's ties to those things, thus accomplishing the human dis-possession of the material convoy. In qualitative interviews in 79 households in the Midwestern United States, older adults reported their experience with possession sales associated with residential relocation. Among this group, three-quarters of the households downsized by selling some belongings. Informal sales seemed the least fraught of all strategies, estate sales had mixed reviews, and garage sales were recalled as laborious. Sellers’ efforts were eased by social relations and social networks as helpers and buyers came forward. As selling proceeded, sentiment about possessions waned as their materiality and economic value came to the fore, easing their detachment from the household. Possession selling is challenging because older adults are limited in the knowledge, skills, and efforts that they can apply to the recommodification of their belongings. Selling can nonetheless be encouraged as a divestment strategy as long as the frustrations and drawbacks are transparent, and the goal of ridding is kept in view. PMID:26162722

  4. Lateral gene transfer in the subsurface

    SciTech Connect

    Barkay, Tamar; Sobecky, Patricia

    2007-08-27

    Lateral gene transfer (LGT) is an important adaptive mechanism among prokaryotic organisms. This mechanism is particularly important for the response of microorganisms to changing environmental conditions because it facilitates the transfer of a large number of genes and their rapid expression. Together the transferred genes promote rapid genetic and metabolic changes that may enhance survival to newly established and sometimes hostile environmental conditions. The goal of our project was to examine if and how LGT enhances microbial adaptation to toxic heavy metals in subsurface environments that had been contaminated by mixed wastes due to activities associated with the production of nuclear energy and weapons. This task has been accomplished by dividing the project to several sub-tasks. Thus, we: (1) Determined the level of resistance of subsurface bacterial isolates to several toxic metals, all identified as pollutants of concern in subsurface environments; (2) Designed, tested, and applied, a molecular approach that determined whether metal resistance genes had evolved by LGT among subsurface bacteria; and (3) Developed a DNA hybridization array for the identification of broad host range plasmids and of metal resistance plasmids. The results are briefly summarized below with references to published papers and manuscripts in preparation where details about our research can be found. Additional information may be found in copies of our published manuscripts and conference proceedings, and our yearly reports that were submitted through the RIMS system.

  5. Emotional Perception Deficits in Amyotrophic Lateral Sclerosis

    PubMed Central

    Zimmerman BA, Erin K.; Eslinger PhD, Paul J.; MD, Zachary Simmons; Barrett MD, Anna M.

    2007-01-01

    Objective Cognitive deficits associated with frontal lobe dysfunction can occur in amyotrophic lateral sclerosis (ALS), particularly in individuals with bulbar ALS who can also suffer pathological emotional lability. Since frontal pathophysiology can alter emotional perception, we examined whether emotional perception deficits occur in ALS, and whether they are related to depressive or dementia symptoms. Methods Bulbar ALS participants (n = 13) and age-matched healthy normal controls (n = 12) completed standardized tests of facial and prosodic emotional recognition, the Geriatric Depression Scale, and the Mini-Mental State Examination. Participants identified the basic emotion (happy, sad, angry, afraid, surprised, disgusted) that matched 39 facial expressions and 28 taped, semantically neutral, intoned sentences. Results ALS patients performed significantly worse than controls on facial emotional recognition but not on prosodic emotional recognition. Eight of 13 patients (62%) scored below the 95% Confidence Interval of controls in recognizing facial emotions, and 3 of these patients (23% overall) also scored lower in prosody recognition. Among the 8 patients with emotional perceptual impairment, one-half did not have depressive, or memory or cognitive symptoms on screening, while the remainder showed dementia symptoms alone or together with depressive symptoms. Conclusions Emotional recognition deficits occur in bulbar ALS, particularly with emotional facial expressions, and can arise independent of depressive and dementia symptoms or co-morbid with depression and dementia. These findings expands the scope of cognitive dysfunction detected in ALS, and bolsters the view of ALS as a multisystem disorder involving cognitive as well as motor deficits. PMID:17558250

  6. Early Word Recognition and Later Language Skills

    PubMed Central

    Junge, Caroline; Cutler, Anne

    2014-01-01

    Recent behavioral and electrophysiological evidence has highlighted the long-term importance for language skills of an early ability to recognize words in continuous speech. We here present further tests of this long-term link in the form of follow-up studies conducted with two (separate) groups of infants who had earlier participated in speech segmentation tasks. Each study extends prior follow-up tests: Study 1 by using a novel follow-up measure that taps into online processing, Study 2 by assessing language performance relationships over a longer time span than previously tested. Results of Study 1 show that brain correlates of speech segmentation ability at 10 months are positively related to 16-month-olds’ target fixations in a looking-while-listening task. Results of Study 2 show that infant speech segmentation ability no longer directly predicts language profiles at the age of five. However, a meta-analysis across our results and those of similar studies (Study 3) reveals that age at follow-up does not moderate effect size. Together, the results suggest that infants’ ability to recognize words in speech certainly benefits early vocabulary development; further observed relationships of later language skills to early word recognition may be consequent upon this vocabulary size effect. PMID:25347057

  7. Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis

    PubMed Central

    Shi, Ping; Gal, Jozsef; Kwinter, David M.; Liu, Xiaoyan; Zhu, Haining

    2009-01-01

    The etiology of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains to be better understood. Based on the studies from ALS patients and transgenic animal models, it is believed that ALS is likely to be a multifactorial and multisystem disease. Many mechanisms have been postulated to be involved in the pathology of ALS, such as oxidative stress, glutamate excitotoxicity, mitochondrial damage, defective axonal transport, glia cell pathology and aberrant RNA metabolism. Mitochondria, which play crucial roles in excitotoxicity, apoptosis and cell survival, have shown to be an early target in ALS pathogenesis and contribute to the disease progression. Morphological and functional defects in mitochondria were found in both human patients and ALS mice overexpressing mutant SOD1. Mutant SOD1 was found to be preferentially associated with mitochondria and subsequently impair mitochondrial function. Recent studies suggest that axonal transport of mitochondria along microtubules and mitochondrial dynamics may also be disrupted in ALS. These results also illustrate the critical importance of maintaining proper mitochondrial function in axons and neuromuscular junctions, supporting the emerging “dying-back” axonopathy model of ALS. In this review, we will discuss how mitochondrial dysfunction has been linked to the ALS variants of SOD1 and the mechanisms by which mitochondrial damage contributes to the disease etiology. PMID:19715760

  8. Amyotrophic Lateral Sclerosis: New Perpectives and Update

    PubMed Central

    Orsini, Marco; Oliveira, Acary Bulle; Nascimento, Osvaldo J.M.; Reis, Carlos Henrique Melo; Leite, Marco Antonio Araujo; de Souza, Jano Alves; Pupe, Camila; de Souza, Olivia Gameiro; Bastos, Victor Hugo; de Freitas, Marcos R.G.; Teixeira, Silmar; Bruno, Carlos; Davidovich, Eduardo; Smidt, Benny

    2015-01-01

    Amyotrophic lateral sclerosis (ALS), Charcot’s disease or Lou Gehrig’s disease, is a term used to cover the spetrum of syndromes caracterized by progressive degeneration of motor neurons, a paralytic disorder caused by motor neuron degeneration. Currently, there are approximately 25,000 patients with ALS in the USA, with an average age of onset of 55 years. The incidence and prevalence of ALS are 1-2 and 4-6 per 100,000 each year, respectively, with a lifetime ALS risk of 1/600 to 1/1000. It causes progressive and cumulative physical disabilities, and leads to eventual death due to respiratory muscle failure. ALS is diverse in its presentation, course, and progression. We do not yet fully understand the causes of the disease, nor the mechanisms for its progression; thus, we lack effective means for treating this disease. In this chapter, we will discuss the diagnosis, treatment, and how to cope with impaired function and end of life based on of our experience, guidelines, and clinical trials. Nowadays ALS seems to be a more complex disease than it did two decades – or even one decade – ago, but new insights have been plentiful. Clinical trials should be seen more as experiments on pathogenic mechanisms. A medication or combination of medications that targets more than one pathogenic pathway may slow disease progression in an additive or synergistic fashion. PMID:26487927

  9. Epidemiologic correlates of sporadic amyotrophic lateral sclerosis

    SciTech Connect

    Armon, C.; Kurland, L.T.; Daube, J.R.; O'Brien, P.C. )

    1991-07-01

    The authors evaluated 74 selected patients with amyotrophic lateral sclerosis (ALS) and 201 matched controls for risk factors for ALS by a case-control design and a sequential questionnaire/interview technique to quantitate biographic data. They analyzed occupational and recreational data only for 47 male patients and 47 corresponding patient controls; data for women were insufficient. They used nonparametric analyses to evaluate five primary comparisons of ALS patients with controls: (1) more hard physical labor, p not significant (NS); (2) greater frequency of neurodegenerative disease in family members, p NS; (3) greater exposure to lead, p less than 0.05; (4) more years lived in a rural community, p NS; and (5) more trauma or major surgery, p NS. Men with ALS had worked more frequently at blue-collar jobs (although not a statistically significant difference, p = 0.10) and at welding or soldering (p less than 0.01). These results suggest that there may be an association between ALS in men and exposure to lead vapor. The limited nature of the association favors a multifactorial etiologic mechanism of ALS.

  10. Lateral gene transfer from the dead.

    PubMed

    Szöllosi, Gergely J; Tannier, Eric; Lartillot, Nicolas; Daubin, Vincent

    2013-05-01

    In phylogenetic studies, the evolution of molecular sequences is assumed to have taken place along the phylogeny traced by the ancestors of extant species. In the presence of lateral gene transfer, however, this may not be the case, because the species lineage from which a gene was transferred may have gone extinct or not have been sampled. Because it is not feasible to specify or reconstruct the complete phylogeny of all species, we must describe the evolution of genes outside the represented phylogeny by modeling the speciation dynamics that gave rise to the complete phylogeny. We demonstrate that if the number of sampled species is small compared with the total number of existing species, the overwhelming majority of gene transfers involve speciation to and evolution along extinct or unsampled lineages. We show that the evolution of genes along extinct or unsampled lineages can to good approximation be treated as those of independently evolving lineages described by a few global parameters. Using this result, we derive an algorithm to calculate the probability of a gene tree and recover the maximum-likelihood reconciliation given the phylogeny of the sampled species. Examining 473 near-universal gene families from 36 cyanobacteria, we find that nearly a third of transfer events (28%) appear to have topological signatures of evolution along extinct species, but only approximately 6% of transfers trace their ancestry to before the common ancestor of the sampled cyanobacteria.

  11. Early environment influences later performance in fishes.

    PubMed

    Jonsson, B; Jonsson, N

    2014-08-01

    Conditions fish encounter during embryogenesis and early life history can leave lasting effects not only on morphology, but also on growth rate, life-history and behavioural traits. The ecology of offspring can be affected by conditions experienced by their parents and mother in particular. This review summarizes such early impacts and their ecological influences for a variety of teleost species, but with special reference to salmonids. Growth and adult body size, sex ratio, egg size, lifespan and tendency to migrate can all be affected by early influences. Mechanisms behind such phenotypically plastic impacts are not well known, but epigenetic change appears to be one central mechanism. The thermal regime during development and incubation is particularly important, but also early food consumption and intraspecific density can all be responsible for later life-history variation. For behavioural traits, early experiences with effects on brain, sensory development and cognition appear essential. This may also influence boldness and other social behaviours such as mate choice. At the end of the review, several issues and questions for future studies are given. PMID:24961386

  12. The epidemiology of amyotrophic lateral sclerosis.

    PubMed

    Talbott, E O; Malek, A M; Lacomis, D

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults and is characterized by neurodegeneration of motor neurons in the brain and spinal cord. The incidence of ALS is approximately 1-2.6 cases per 100 000 persons annually, whereas the prevalence is approximately 6 cases per 100 000. The average age of onset of ALS is currently 58-60 years and the average survival from onset to death is 3-4 years. Between October 19, 2010 and December 31, 2011, there were an estimated 12 187 prevalent cases diagnosed with definite ALS in the USA alone. Sporadic ALS (90-95%) constitutes the large majority of cases, while the remaining 5-10% are hereditary and termed familial ALS. Sporadic ALS is suspected to involve genetic susceptibility to environmental risk factors. The purpose of this review is to present a clinical overview of ALS and provide an epidemiologic summary of personal and environmental risk factors shown to be related to the risk of disease. A discussion of the most recent research initiatives is also included. PMID:27637961

  13. Controversies and priorities in amyotrophic lateral sclerosis

    PubMed Central

    Turner, Martin R; Hardiman, Orla; Benatar, Michael; Brooks, Benjamin R; Chio, Adriano; de Carvalho, Mamede; Ince, Paul G; Lin, Cindy; Miller, Robert G; Mitsumoto, Hiroshi; Nicholson, Garth; Ravits, John; Shaw, Pamela J; Swash, Michael; Talbot, Kevin; Traynor, Bryan J; den Berg, Leonard H Van; Veldink, Jan H; Vucic, Steve; Kiernan, Matthew C

    2015-01-01

    Summary Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding concepts regarding the cause and natural history of ALS, coming soon after the pathological unification of ALS with frontotemporal dementia through a shared pathological signature of cytoplasmic inclusions of the ubiquitinated protein TDP-43. However, with profound clinical, prognostic, neuropathological, and now genetic heterogeneity, the concept of ALS as one disease appears increasingly untenable. This background calls for the development of a more sophisticated taxonomy, and an appreciation of ALS as the breakdown of a wider network rather than a discrete vulnerable population of specialised motor neurons. Identification of C9orf72 repeat expansions in patients without a family history of ALS challenges the traditional division between familial and sporadic disease. By contrast, the 90% of apparently sporadic cases and incomplete penetrance of several genes linked to familial cases suggest that at least some forms of ALS arise from the interplay of multiple genes, poorly understood developmental, environmental, and age-related factors, as well as stochastic events. PMID:23415570

  14. [Congenital heart disease, heterotaxia and laterality].

    PubMed

    Icardo, José Manuel; García Rincón, Juan Manuel; Ros, María Angeles

    2002-09-01

    Congenital heart disease occurs in about 0,8% of all newborns. Many cardiac malformations occur among relatives and have a polymorphic presentation. The origin of most congenital heart disease is thought to be multifactorial, implying both anomalous expression of genes and the influence of epigenetic factors. However, in a small number of cases, the origin of congenital heart disease has been directly related to chromosomal anomalies or to defects in a single gene. Curiously, defects in a single gene can explain a polymorphic presentation if the anomalous gene controls a basic embryonic process that affects different organs in time and space. Some of these genes appear to control the establishment of laterality. The establishment of the left-right asymmetry starts at the Hensen node. Here, the initial embryonic symmetry is broken by cascades of gene activation that confer specific properties on the left and right sides of the embryo. Although there are variations between species, some basic patterns of gene expression (Nodal, Pitx2) appear to be maintained along the phylogenetic scale. Anomalous expression of these genes induces the heterotaxia syndrome, which usually courses with congenital heart disease. The development of heart malformations is illustrated with the mouse mutant iv/iv, which is a model for the heterotaxia syndrome and the associated congenital heart disease.

  15. Decisional Capacity in Amyotrophic Lateral Sclerosis.

    PubMed

    Khin Khin, Eindra; Minor, Darlinda; Holloway, Amanda; Pelleg, Ayla

    2015-06-01

    The cognitive and behavioral changes that can be observed in the neurodegenerative terminal disease amyotrophic lateral sclerosis (ALS), once characterized as purely a motor neuron disease, have become increasingly recognized over the past century. Detecting cognitive deficits earlier and identifying continued changes at regular intervals can lead to improved care, proactive treatments, and earlier discussions about end-of-life wishes. Although medical decisional capacity is required for every treatment decision made, its importance becomes paramount when making decisions on complex medical treatments that will invariably and significantly affect quality of life or life itself. In this review, we conducted a critical analysis of the evidence-based literature on the cognitive and behavioral impairments in ALS that can compromise medical decisional capacity. We review specific ALS-related clinical scenarios in which decisional capacity is of utmost importance and discuss a practical framework for cognitive and behavioral assessment that can be routinely and efficiently used, while being mindful of the confounding factors associated with ALS. Finally, we review models for preserving patient choices that can be used in patients with ALS to help safeguard autonomy and retain dignity toward the end of life. PMID:26071511

  16. Later first marriage and marital success.

    PubMed

    Glenn, Norval D; Uecker, Jeremy E; Love, Robert W B

    2010-09-01

    The research reported here used measures of marital success based on both marital survival and marital quality to assess how well first marriages entered at relatively late ages fare in comparison with those entered younger. Analysis of data from five American data sets indicated that the later marriages fare very well in survival but rather poorly in quality. The greatest indicated likelihood of being in an intact marriage of the highest quality is among those who married at ages 22-25, net of the estimated effects of time since first marriage and several variables that might commonly affect age at marriage and marital outcomes. The negative relationship beyond the early to mid-twenties between age at marriage and marital success is likely to be at least partially spurious, and thus it would be premature to conclude that the optimal time for first marriage for most persons is ages 22-25. However, the findings do suggest that most persons have little or nothing to gain in the way of marital success by deliberately postponing marriage beyond the mid-twenties.

  17. Altered Cortical Communication in Amyotrophic Lateral Sclerosis

    PubMed Central

    Blain-Moraes, Stefanie; Mashour, George A.; Lee, Heonsoo; Huggins, Jane E.; Lee, UnCheol

    2013-01-01

    Amyotrophic lateral sclerosis (ALS) is a disorder associated primarily with the degeneration of the motor system. More recently, functional connectivity studies have demonstrated potentially adaptive changes in ALS brain organization, but disease-related changes in cortical communication remain unknown. We recruited individuals with ALS and age-matched controls to operate a brain-computer interface while electroencephalography was recorded over three sessions. Using normalized symbolic transfer entropy, we measured directed functional connectivity from frontal to parietal (feedback connectivity) and parietal to frontal (feedforward connectivity) regions. Feedback connectivity was not significantly different between groups, but feedforward connectivity was significantly higher in individuals with ALS. This result was consistent across a broad electroencephalographic spectrum (4 – 35 Hz), and in theta, alpha and beta frequency bands. Feedback connectivity has been associated with conscious state and was found to be independent of ALS symptom severity in this study, which may have significant implications for the detection of consciousness in individuals with advanced ALS. We suggest that increases in feedforward connectivity represent a compensatory response to the ALS-related loss of input such that sensory stimuli have sufficient strength to cross the threshold necessary for conscious processing in the global neuronal workspace. PMID:23567743

  18. Possession divestment by sales in later life.

    PubMed

    Ekerdt, David J; Addington, Aislinn

    2015-08-01

    Residential relocation in later life is almost always a downsizing, with many possessions to be divested in a short period of time. This article examines older movers' capacities for selling things, and ways that selling attenuates people's ties to those things, thus accomplishing the human dis-possession of the material convoy. In qualitative interviews in 79 households in the Midwestern United States, older adults reported their experience with possession sales associated with residential relocation. Among this group, three-quarters of the households downsized by selling some belongings. Informal sales seemed the least fraught of all strategies, estate sales had mixed reviews, and garage sales were recalled as laborious. Sellers' efforts were eased by social relations and social networks as helpers and buyers came forward. As selling proceeded, sentiment about possessions waned as their materiality and economic value came to the fore, easing their detachment from the household. Possession selling is challenging because older adults are limited in the knowledge, skills, and efforts that they can apply to the recommodification of their belongings. Selling can nonetheless be encouraged as a divestment strategy as long as the frustrations and drawbacks are transparent, and the goal of ridding is kept in view.

  19. Decoupled echo state networks with lateral inhibition.

    PubMed

    Xue, Yanbo; Yang, Le; Haykin, Simon

    2007-04-01

    Building on some prior work, in this paper we describe a novel structure termed the decoupled echo state network (DESN) involving the use of lateral inhibition. Two low-complexity implementation schemes, namely, the DESN with reservoir prediction (DESN + RP) and DESN with maximum available information (DESN + MaxInfo), are developed: (1) In the multiple superimposed oscillator (MSO) problem, DESN + MaxInfo exhibits three important attributes: lower generalization mean-square error (MSE), better robustness with respect to the random generation of reservoir weight matrix and feedback connections, and robustness to variations in the sparseness of reservoir weight matrix, compared to DESN + RP. (2) For a noiseless nonlinear prediction task, DESN + RP outperforms the DESN + MaxInfo and single reservoir-based ESN approach in terms of lower prediction MSE and better robustness to a change in the number of inputs and sparsity of the reservoir weight matrix. Finally, in a real-life prediction task using noisy sea clutter data, both schemes exhibit higher prediction accuracy and successful design ratio than a conventional ESN with a single reservoir.

  20. Rodent Models of Amyotrophic Lateral Sclerosis.

    PubMed

    Philips, Thomas; Rothstein, Jeffrey D

    2015-06-01

    Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and lower motor neurons in the central nervous system. Patients with ALS develop extensive muscle wasting and atrophy leading to paralysis and death 3 to 5 years after disease onset. The condition may be familial (fALS 10%) or sporadic ALS (sALS, 90%). The large majority of fALS cases are due to genetic mutations in the Superoxide dismutase 1 gene (SOD1, 15% of fALS) and repeat nucleotide expansions in the gene encoding C9ORF72 (∼ 40% to 50% of fALS and ∼ 10% of sALS). Studies suggest that ALS is mediated through aberrant protein homeostasis (i.e., ER stress and autophagy) and/or changes in RNA processing (as in all non-SOD1-mediated ALS). In all of these cases, animal models suggest that the disorder is mediated non-cell autonomously, i.e., not only motor neurons are involved, but glial cells including microglia, astrocytes, and oligodendrocytes, and other neuronal subpopulations are also implicated in the pathogenesis. Provided in this unit is a review of ALS rodent models, including discussion of their relative advantages and disadvantages. Emphasis is placed on correlating the model phenotype with the human condition and the utility of the model for defining the disease process. Information is also presented on RNA processing studies in ALS research, with particular emphasis on the newest ALS rodent models.

  1. Acupuncture for Lateral Epicondylitis: A Systematic Review.

    PubMed

    Tang, Hongzhi; Fan, Huaying; Chen, Jiao; Yang, Mingxiao; Yi, Xuebing; Dai, Guogang; Chen, Junrong; Tang, Liugang; Rong, Haibo; Wu, Junhua; Liang, Fanrong

    2015-01-01

    Objective. This systematic review aimed to assess the effectiveness and safety of acupuncture for lateral epicondylitis (LE). Methods. Seven databases and the WHO International Clinical Trials Registry Platform Search Portal were searched to identify relevant studies. The data were extracted and assessed by two independent authors, and Review Manager Software (V.5.3) was used for data synthesis with effect estimate presented as standard mean difference (SMD) and mean difference (MD) with a 95% confidence interval. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the level of evidence. Results. Four RCTs with 309 participants were included with poor methodological quality. Participants who received acupuncture and acupuncture plus moxibustion with material insulation were likely to have an improvement in elbow functional status and/or myodynamia. The overall quality rated by GRADE was from very low to low. Two studies reported that the needle pain would be the main reason for the dropout. Conclusion. For the small number of included studies with poor methodological quality, no firm conclusion can be drawn regarding the effect of acupuncture of elbow functional status and myodynamia for LE. This trial is registered with CRD42015016199. PMID:26843886

  2. Laterally graded multilayer double-monochromator.

    SciTech Connect

    Als-Nielsen, J.; Erdmann, J.; Gaarde, P.; Krasnicki, S.; Liu, C.; Macrander, A. T.; Maj, J.; Mancini, D.

    1999-09-01

    The authors describe a tunable multilayer monochromator with an adjustable bandpass to be used for reflectivity and grazing incidence diffraction studies on surfaces at energies near 10 keV. Multilayers have a bandpass typically 100 times larger than the Si(111) reflection, and by using multilayers an experimenter can significantly increase data collection rates over those available with a Si monochromator. The transmission through 1 and 2 laterally graded multilayer (LGML) reflections was recorded versus photon energy. The identical LGMLs were comprised of 60 bilayers of W and C on 100 x 25 x 3 mm float glass with a bilayer spacing varying from 35 to 60 {angstrom}. The average gradient was 0.27 {angstrom}/mm along the long dimension. The rms deviation of the data for the bilayer spacing from a linear fit was 0.36 {angstrom}. Data were obtained for a nondispersive ({+-}) double-multilayer arrangement. The relative bandpass width (FWHM) when the two multilayers exposed the same bilayer spacing was measured to be 2.2% with a transmission of 78.7 {+-} 1.6%. This value is consistent with the transmission of 88.9% that they also measured for a single LGML at HASYLAB beamline D4. The bandpass was tunable in the range 1.1% to 2.2%.

  3. Penetration and lateral diffusion characteristics of polycrystalline graphene barriers.

    PubMed

    Yoon, Taeshik; Mun, Jeong Hun; Cho, Byung Jin; Kim, Taek-Soo

    2014-01-01

    We report penetration and lateral diffusion behavior of environmental molecules on synthesized polycrystalline graphene. Penetration occurs through graphene grain boundaries resulting in local oxidation. However, when the penetrated molecules diffuse laterally, the oxidation region will expand. Therefore, we measured the lateral diffusion rate along the graphene-copper interface for the first time by the environment-assisted crack growth test. It is clearly shown that the lateral diffusion is suppressed due to the high van der Waals interaction. Finally, we employed bilayer graphene for a perfect diffusion barrier facilitated by decreased defect density and increased lateral diffusion path.

  4. Lateral Thoracic Osteoplastic Rib-Sparing Technique Used for Lateral Spine Surgery: Technical Note

    PubMed Central

    Fisahn, Christian; Tubbs, R. Shane; Page, Jeni; Rice, Richard; Paulson, David; Kazemi, Noojan; Hanscom, David; Oskouian, Rod J

    2016-01-01

    Of patients who have undergone lateral approaches to the thoracic spine, surgical site postoperative pain appears to be greater among those who have undergone transection and removal of a rib segment than those who have not. Therefore, techniques that conserve anatomical position and minimize tissue disruption would theoretically result in less pain and a quicker recovery. Herein, we describe a rib-sparing osteoplastic technique used when rib segments need to be displaced in order to create an unobscured corridor to the operative target. Our approach minimizes soft tissue disruption and restores the anatomical function of the rib. Based on our experience, these patients report less pain, mobilize earlier, and are discharged sooner than those who have had rib segments sacrificed as part of a lateral approach to the spine. PMID:27551648

  5. Anatomy of the lateral antebrachial cutaneous nerve in relation to the lateral epicondyle and cephalic vein.

    PubMed

    Wongkerdsook, Wachara; Agthong, Sithiporn; Amarase, Chavarin; Yotnuengnit, Pattarapol; Huanmanop, Thanasil; Chentanez, Vilai

    2011-01-01

    The lateral antebrachial cutaneous nerve (LACN) is the terminal sensory branch of the musculocutaneous nerve supplying the lateral aspect of forearm. Because of its close proximity to the biceps brachii tendon (BBT), the lateral epicondyle (LE), and the cephalic vein (CV), surgery and venipuncture in the cubital fossa can injure the LACN. Measurement data regarding the relative anatomy of LACN are scarce. We, therefore, dissected 96 upper extremities from 26 males and 22 females to expose the LACN in the cubital fossa and forearm. The LACN consistently emerged from the lateral margin of BBT. It then pierced the deep fascia distal to the interepicondylar line (IEL) in 84.4% with mean distances of 1.8 ± 1.1 and 1.2 ± 0.9 cm (male and female, respectively). At the level of IEL, the LACN in all cases was medial to the LE (5.9 ± 1.1 cm male and 5.2 ± 0.9 cm female). Two types of branching were observed: single trunk (78.1%) and bifurcation (21.9%). Asymmetry in the branching pattern was observed in 6 males and 1 female. Concerning the relationship to the CV, the LACN ran medially within 1 cm at the level of IEL in 78.7%. Moreover, in 10 specimens, the LACN was directly beneath the CV. In the forearm, the LACN tends to course medial to the CV. Significant differences in the measurement data between genders but not sides were found in some parameters. These data are important for avoiding LACN injury and locating the LACN during relevant medical procedures.

  6. Strength of forelimb lateralization predicts motor errors in an insect

    PubMed Central

    Bell, Adrian T. A.

    2016-01-01

    Lateralized behaviours are widespread in both vertebrates and invertebrates, suggesting that lateralization is advantageous. Yet evidence demonstrating proximate or ultimate advantages remains scarce, particularly in invertebrates or in species with individual-level lateralization. Desert locusts (Schistocerca gregaria) are biased in the forelimb they use to perform targeted reaching across a gap. The forelimb and strength of this bias differed among individuals, indicative of individual-level lateralization. Here we show that strongly biased locusts perform better during gap-crossing, making fewer errors with their preferred forelimb. The number of targeting errors locusts make negatively correlates with the strength of forelimb lateralization. This provides evidence that stronger lateralization confers an advantage in terms of improved motor control in an invertebrate with individual-level lateralization. PMID:27651534

  7. Surgical endodontic management of infected lateral canals of maxillary incisors

    PubMed Central

    2015-01-01

    This case report presents surgical endodontic management outcomes of maxillary incisors that were infected via the lateral canals. Two cases are presented in which endodontically-treated maxillary central incisors had sustained lateral canal infections. A surgical endodontic treatment was performed on both teeth. Flap elevation revealed vertical bone destruction along the root surface and infected lateral canals, and microscopy revealed that the lateral canals were the origin of the lesions. After the infected lateral canals were surgically managed, both teeth were asymptomatic and labial fistulas were resolved. There were no clinical or radiographic signs of surgical endodontic management failure at follow-up visits. This case report highlights the clinical significance and surgical endodontic management of infected lateral canal of maxillary incisor. It is important to be aware of root canal anatomy variability in maxillary incisors. Maxillary central incisors infected via the lateral canal can be successfully managed by surgical endodontic treatment. PMID:25671217

  8. Diagnostic considerations of lateral column foot pain in athletes.

    PubMed

    Traister, Eric; Simons, Stephen

    2014-01-01

    Foot maladies are often classified descriptively by general foot locations, i.e., forefoot, midfoot, and rearfoot. However, common vernacular verbiage, implicating a common biomechanical purpose, also applies pathology to the medial or lateral foot column. Although imprecisely defined, lateral column injuries to the foot encompass conditions that affect any of the lateral side of the foot from the calcaneus to the toes. The lateral column of the foot includes the calcaneus, the cuboid, the fourth and fifth metatarsals as well as the calcaneocuboid, cuboido-metatarsal, and intermetatarsal joints. It may be helpful to think in a "lateral column" fashion when evaluating and treating certain lateral foot injuries, load patterns, and biomechanical or anatomical faults. Misdiagnosed injuries in this area of the foot can be a source of great morbidity to the athlete. It is important for the clinician to be aware of common conditions presenting as pain to the lateral side of the foot.

  9. Strength of forelimb lateralization predicts motor errors in an insect.

    PubMed

    Bell, Adrian T A; Niven, Jeremy E

    2016-09-01

    Lateralized behaviours are widespread in both vertebrates and invertebrates, suggesting that lateralization is advantageous. Yet evidence demonstrating proximate or ultimate advantages remains scarce, particularly in invertebrates or in species with individual-level lateralization. Desert locusts (Schistocerca gregaria) are biased in the forelimb they use to perform targeted reaching across a gap. The forelimb and strength of this bias differed among individuals, indicative of individual-level lateralization. Here we show that strongly biased locusts perform better during gap-crossing, making fewer errors with their preferred forelimb. The number of targeting errors locusts make negatively correlates with the strength of forelimb lateralization. This provides evidence that stronger lateralization confers an advantage in terms of improved motor control in an invertebrate with individual-level lateralization. PMID:27651534

  10. Surgical endodontic management of infected lateral canals of maxillary incisors.

    PubMed

    Jang, Ji-Hyun; Lee, Jung-Min; Yi, Jin-Kyu; Choi, Sung-Baik; Park, Sang-Hyuk

    2015-02-01

    This case report presents surgical endodontic management outcomes of maxillary incisors that were infected via the lateral canals. Two cases are presented in which endodontically-treated maxillary central incisors had sustained lateral canal infections. A surgical endodontic treatment was performed on both teeth. Flap elevation revealed vertical bone destruction along the root surface and infected lateral canals, and microscopy revealed that the lateral canals were the origin of the lesions. After the infected lateral canals were surgically managed, both teeth were asymptomatic and labial fistulas were resolved. There were no clinical or radiographic signs of surgical endodontic management failure at follow-up visits. This case report highlights the clinical significance and surgical endodontic management of infected lateral canal of maxillary incisor. It is important to be aware of root canal anatomy variability in maxillary incisors. Maxillary central incisors infected via the lateral canal can be successfully managed by surgical endodontic treatment.

  11. Lateral patellofemoral ligament reconstruction to restore functional capacity in patients previously undergoing lateral retinacular release

    PubMed Central

    Beckert, Mitch; Crebs, Dylan; Nieto, Michael; Gao, Yubo; Albright, John

    2016-01-01

    AIM To study patient outcomes after surgical correction for iatrogenic patellar instability. METHODS This retrospective study looked at 17 patients (19 knees) suffering from disabling medial patellar instability following lateral release surgery. All patients underwent lateral patellofemoral ligament (LPFL) reconstruction by a single surgeon. Assessments in all 19 cases included functional outcome scores, range of motion, and assessment for the presence of apprehension sign of the patella to determine if LPFL reconstruction surgery was successful at restoring patellofemoral stability. RESULTS No patients reported any residual postoperative symptoms of patellar instability. Also no patients demonstrated medial patellar apprehension or examiner induced subluxation with the medial instability test described earlier following LPFL reconstruction. Furthermore, all patients recovered normal range of motion compared to the contralateral limb. For patients with pre and postoperative outcome scores, the mean overall knee injury and osteoarthritis outcome score increased significantly, from 34.39 preoperatively (range: 7.7-70.12) to 69.54 postoperatively (range: 26.82-91.46) at final follow-up (P < 0.0001). CONCLUSION This novel technique for LPFL reconstruction is effective at restoring lateral restraint of the patellofemoral joint and improving joint functionality. PMID:27574606

  12. Tracing the Geomorphic Signature of Lateral Faulting

    NASA Astrophysics Data System (ADS)

    Duvall, A. R.; Tucker, G. E.

    2012-12-01

    Active strike-slip faults are among the most dangerous geologic features on Earth. Unfortunately, it is challenging to estimate their slip rates, seismic hazard, and evolution over a range of timescales. An under-exploited tool in strike-slip fault characterization is quantitative analysis of the geomorphic response to lateral fault motion to extract tectonic information directly from the landscape. Past geomorphic work of this kind has focused almost exclusively on vertical motion, despite the ubiquity of horizontal motion in crustal deformation and mountain building. We seek to address this problem by investigating the landscape response to strike-slip faulting in two ways: 1) examining the geomorphology of the Marlborough Fault System (MFS), a suite of parallel strike-slip faults within the actively deforming South Island of New Zealand, and 2) conducting controlled experiments in strike-slip landscape evolution using the CHILD landscape evolution model. The MFS offers an excellent natural experiment site because fault initiation ages and cumulative displacements decrease from north to south, whereas slip rates increase over four fold across a region underlain by a single bedrock unit (Torlesse Greywacke). Comparison of planform and longitudinal profiles of rivers draining the MFS reveals strong disequilibrium within tributaries that drain to active fault strands, and suggests that river capture related to fault activity may be a regular process in strike-slip fault zones. Simple model experiments support this view. Model calculations that include horizontal motion as well as vertical uplift demonstrate river lengthening and shortening due to stream capture in response to shutter ridges sliding in front of stream outlets. These results suggest that systematic variability in fluvial knickpoint location, drainage area, and incision rates along different faults or fault segments may be expected in catchments upstream of strike-slip faults and could act as useful

  13. Laterally constrained inversion for CSAMT data interpretation

    NASA Astrophysics Data System (ADS)

    Wang, Ruo; Yin, Changchun; Wang, Miaoyue; Di, Qingyun

    2015-10-01

    Laterally constrained inversion (LCI) has been successfully applied to the inversion of dc resistivity, TEM and airborne EM data. However, it hasn't been yet applied to the interpretation of controlled-source audio-frequency magnetotelluric (CSAMT) data. In this paper, we apply the LCI method for CSAMT data inversion by preconditioning the Jacobian matrix. We apply a weighting matrix to Jacobian to balance the sensitivity of model parameters, so that the resolution with respect to different model parameters becomes more uniform. Numerical experiments confirm that this can improve the convergence of the inversion. We first invert a synthetic dataset with and without noise to investigate the effect of LCI applications to CSAMT data, for the noise free data, the results show that the LCI method can recover the true model better compared to the traditional single-station inversion; and for the noisy data, the true model is recovered even with a noise level of 8%, indicating that LCI inversions are to some extent noise insensitive. Then, we re-invert two CSAMT datasets collected respectively in a watershed and a coal mine area in Northern China and compare our results with those from previous inversions. The comparison with the previous inversion in a coal mine shows that LCI method delivers smoother layer interfaces that well correlate to seismic data, while comparison with a global searching algorithm of simulated annealing (SA) in a watershed shows that though both methods deliver very similar good results, however, LCI algorithm presented in this paper runs much faster. The inversion results for the coal mine CSAMT survey show that a conductive water-bearing zone that was not revealed by the previous inversions has been identified by the LCI. This further demonstrates that the method presented in this paper works for CSAMT data inversion.

  14. Lateral Shock of the R Aquarii Jet

    NASA Technical Reports Server (NTRS)

    Hollis, J. M.; Pedelty, J. A.; Kafatos, M.

    1997-01-01

    The R Aqr jet was observed with the VLA B-configuration at two epochs separated by approximately 13.2 yr. Comparison of the resulting 6 cm continuum images show that the radio jet has undergone a lateral counterclockwise rotation of approximately 6 deg-12 deg on the plane of the sky. The model of jet parcels on independent trajectories is difficult to reconcile with these observations and leads us to consider a path-oriented jet (i.e., younger parcels follow the same path as older parcels). Comparison of the most recent radio image with a nearly contemporaneous HST/FOC ultraviolet image at approximately 2330 Angstroms suggests that the ultraviolet emission lies along the leading side of the rotating radio jet. In conjunction with a proper motion analysis of the jet material that yields empirical space-velocity and resulting acceleration-magnitude relationships as a function of distance from the central source, we evaluate the observational results in terms of a schematic model in which the jet emission consists of plane-parallel isothermal shocks along the leading edge of rotation. In such a radiating shock, the ultraviolet-emitting region is consistent with the adiabatic region in the form of a high-temperature, low-density sheath that surrounds the cooled postshock radio-emitting region. Within the context of the schematic model, we obtain the temperatures, densities, and pressures within the preshock, adiabatic, and postshock regions as a function of distance from the central source; the physical parameters so derived compare favorably to previously published estimates. We obtain a total jet mass of 3.1 x 10(exp -5) solar mass and an age of approximately 115 yr. We evaluate the model in the context of its density-boundary condition, its applicability to an episodic or quasi-continuous jet, and angular momentum considerations.

  15. [Announcement of amyotrophic lateral sclerosis diagnosis].

    PubMed

    Couratier, P; Desport, J C; Torny, F; Lacoste, M

    2006-06-01

    Breaking the news of amyotrophic lateral sclerosis (ALS) is considered as a daunting task in most cases and is not a standardizable procedure. However, proven techniques exist to reduce the trauma to the patient. Announcing ALS falls upen the neurologist who must respect the ethical principle of the patient's independence. After the diagnosis is firmly established, the patient should be informed that he or she has a progressive disease of the motor nerves, for which no curative therapy is available. The name of the disease must be stated and explained. If the family history is negative, it is reassuring for the patient and family to know that their children are unlikely to be at risk. Positive aspects (no pain, no disturbances in sensation, cognition, memory and continence) should be stressed as well as the availability of efficient palliative measures for practically all symptoms. Current research efforts, and when available, the possibility of taking part in clinical studies of new drugs should be pointed out as a means of hope. The answer to the question of prognosis should include the information that there are no sudden worsenings to be expected, that the course of ALS may vary between months and decades, that making a firm statement on prognosis all but impossible for any single patient and that respiratory function may worsen during the disease course. It is therefore mandatory to inform patients and families about the existence of ALS patients'associations. The way the patient is told the diagnosis is of great importance and is considered as a multiple-step procedure. Discussion should take place in a private and quiet room and respect some fundamental objectives such as finding out what the patient already knows or suspects and how much more the patient wants to know, observing and responding to the patient's reactions, reinforcing the information and planning the future. It is proven that communicating the diagnosis of ALS in an empathetic fashion is an

  16. Homozygosity analysis in amyotrophic lateral sclerosis

    PubMed Central

    Mok, Kin; Laaksovirta, Hannu; Tienari, Pentti J; Peuralinna, Terhi; Myllykangas, Liisa; Chiò, Adriano; Traynor, Bryan J; Nalls, Michael A; Gurunlian, Nicole; Shatunov, Aleksey; Restagno, Gabriella; Mora, Gabriele; Nigel Leigh, P; Shaw, Chris E; Morrison, Karen E; Shaw, Pamela J; Al-Chalabi, Ammar; Hardy, John; Orrell, Richard W

    2013-01-01

    Amyotrophic lateral sclerosis (ALS) may appear to be familial or sporadic, with recognised dominant and recessive inheritance in a proportion of cases. Sporadic ALS may be caused by rare homozygous recessive mutations. We studied patients and controls from the UK and a multinational pooled analysis of GWAS data on homozygosity in ALS to determine any potential recessive variant leading to the disease. Six-hundred and twenty ALS and 5169 controls were studied in the UK cohort. A total of 7646 homozygosity segments with length >2 Mb were identified, and 3568 rare segments remained after filtering ‘common' segments. The mean total of the autosomal genome with homozygosity segments was longer in ALS than in controls (unfiltered segments, P=0.05). Two-thousand and seventeen ALS and 6918 controls were studied in the pooled analysis. There were more regions of homozygosity segments per case (P=1 × 10−5), a greater proportion of cases harboured homozygosity (P=2 × 10−5), a longer average length of segment (P=1 × 10−5), a longer total genome coverage (P=1 × 10−5), and a higher rate of these segments overlapped with RefSeq gene regions (P=1 × 10−5), in ALS patients than controls. Positive associations were found in three regions. The most significant was in the chromosome 21 SOD1 region, and also chromosome 1 2.9–4.8 Mb, and chromosome 5 in the 65 Mb region. There are more than twenty potential genes in these regions. These findings point to further possible rare recessive genetic causes of ALS, which are not identified as common variants in GWAS. PMID:23612577

  17. Measuring lateral shuffle and side cut performance.

    PubMed

    Whitting, John W; de Melker Worms, Jonathan L A; Maurer, Christian; Nigg, Sandro R; Nigg, Benno M

    2013-11-01

    Lateral shuffle and side cut (SSC) movements are defensive basketball movements where movement speed is critical to performance. The purpose of this study was to compare SSC data obtained using timing lights with motion capture system data and to determine the most appropriate method for measuring SSC performance. Shuffle time data were recorded using both timing lights and a motion capture system while 9 male subjects performed 2 different SSC movement sets, with and without controlling for arm movements, which may influence performance times. Shuffle and side cut times and SSC displacements were used to calculate mean shuffle velocity for each trial. The SEs for the motion capture system were estimated for SSC times (± 4.2 milliseconds; ~0.24% of mean shuffle time) and velocities (± 5.5 mm · s; ~0.24% of mean shuffle velocity), respectively, indicating high levels of precision. Timing light movement time variability was significantly higher during the uncontrolled (SD = 42 milliseconds) when compared with the controlled (SD = 9 milliseconds, p < 0.001) condition, indicating a significant reduction in variability by controlling non-performance-related variability such as arm movement. A significant positive correlation was found between SSC time and SSC displacement (r = 0.42) indicating that performance times were dependent on displacement. Furthermore, the variance in motion-captured SSC velocity was significantly smaller than the variance in velocity determined using timing lights (p < 0.05). We concluded that motion-captured SSC velocity data reduced systematic errors and non-performance-related movement variability and, therefore, was better able to reflect true performance. As true performance variability in human movement provides important information, the presented method for calculating SSC velocity in this study is recommended for assessing SSC performance.

  18. [Announcement of amyotrophic lateral sclerosis diagnosis].

    PubMed

    Couratier, P; Desport, J C; Torny, F; Lacoste, M

    2006-06-01

    Breaking the news of amyotrophic lateral sclerosis (ALS) is considered as a daunting task in most cases and is not a standardizable procedure. However, proven techniques exist to reduce the trauma to the patient. Announcing ALS falls upen the neurologist who must respect the ethical principle of the patient's independence. After the diagnosis is firmly established, the patient should be informed that he or she has a progressive disease of the motor nerves, for which no curative therapy is available. The name of the disease must be stated and explained. If the family history is negative, it is reassuring for the patient and family to know that their children are unlikely to be at risk. Positive aspects (no pain, no disturbances in sensation, cognition, memory and continence) should be stressed as well as the availability of efficient palliative measures for practically all symptoms. Current research efforts, and when available, the possibility of taking part in clinical studies of new drugs should be pointed out as a means of hope. The answer to the question of prognosis should include the information that there are no sudden worsenings to be expected, that the course of ALS may vary between months and decades, that making a firm statement on prognosis all but impossible for any single patient and that respiratory function may worsen during the disease course. It is therefore mandatory to inform patients and families about the existence of ALS patients'associations. The way the patient is told the diagnosis is of great importance and is considered as a multiple-step procedure. Discussion should take place in a private and quiet room and respect some fundamental objectives such as finding out what the patient already knows or suspects and how much more the patient wants to know, observing and responding to the patient's reactions, reinforcing the information and planning the future. It is proven that communicating the diagnosis of ALS in an empathetic fashion is an

  19. Enhanced performance of methamphetamine lateral flow cassettes using an electronic lateral flow reader.

    PubMed

    Smith, Jerome P; Sammons, Deborah L; Robertson, Shirley A; Snawder, John E

    2015-01-01

    Surface contamination from methamphetamine in meth labs continues to be a problem. We had previously developed a lateral flow assay cassette for field detection of methamphetamine contamination that is commercially available and has been used by a number of groups to assess contamination. This cassette uses the complete disappearance of the test line as an end point for detection of 50 ng/100 cm2 of methamphetamine contamination for surface sampling with cotton swabs. In the present study, we further evaluate the response of the cassettes using an electronic lateral flow reader to measure the intensities of the test and control lines. The cassettes were capable of detecting 0.25 ng/ml for calibration solutions. For 100 cm2 ceramic tiles that were spiked with methamphetamine and wiped with cotton-tipped wooden swabs wetted in assay/sampling buffer, 1 ng/tile was detected using the reader. Semi-quantitative results can be produced over the range 0-10 ng/ml for calibration solutions and 0-25 ng/tile for spiked tiles using either a 4-parameter logistic fit of test line intensity versus concentration or spiked mass or the ratio of the control line to the test line intensity fit to concentration or spiked mass. Recovery from the tiles was determined to be about 30% using the fitted curves. Comparison of the control line to the test line was also examined as a possible visual detection end point and it was found that the control line became more intense than the test line at 0.5 to 1 ng/ml for calibration solutions or 1 to 2 ng/tile for spiked tiles. Thus the lateral flow cassettes for methamphetamine have the potential to produce more sensitive semi-quantitative results if an electronic lateral flow reader is used and can be more sensitive for detection if the comparison of the control line to the test line is used as the visual end point.

  20. Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis.

    PubMed

    Loew, Laurianne M; Brosseau, Lucie; Tugwell, Peter; Wells, George A; Welch, Vivian; Shea, Beverley; Poitras, Stephane; De Angelis, Gino; Rahman, Prinon

    2014-11-08

    Background Deep transverse friction massage, one of several physical therapy interventions suggested for the management of tendinitis pain, was first demonstrated in the 1930s by Dr James Cyriax, a renowned orthopedic surgeon in England. Its goal is to prevent abnormal fibrous adhesions and abnormal scarring. This is an update of a Cochrane review first published in 2001.Objectives To assess the benefits and harms of deep transverse friction massage for treating lateral elbow or lateral knee tendinitis.Search methods We searched the following electronic databases: the specialized central registry of the Cochrane Field of Physical and Related Therapies,the Cochrane Central Register of Controlled Trials (CENTRAL),MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Clinicaltrials.gov, and the Physiotherapy Evidence Database (PEDro), up until July 2014. The reference lists of these trials were consulted for additional studies.Selection criteria All randomized controlled trials (RCTs) and controlled clinical trials (CCTs) comparing deep transverse friction massage with control or other active interventions for study participants with two eligible types of tendinitis (ie, extensor carpi radialis tendinitis (lateral elbow tendinitis, tennis elbow or lateral epicondylitis or lateralis epicondylitis humeri) and iliotibial band friction syndrome (lateral knee tendinitis)) were selected. Only studies published in English and French languages were included.Data collection and analysis Two review authors independently assessed the studies on the basis of inclusion and exclusion criteria. Results of individual trials were extracted from the included study using extraction forms prepared by two independent review authors before the review was begun.Data were cross-checked by a third review author. Risk of bias of the included studies was assessed using the "Risk of bias"tool of The Cochrane Collaboration. A pooled analysis was performed using

  1. Enhanced performance of methamphetamine lateral flow cassettes using an electronic lateral flow reader

    PubMed Central

    Smith, Jerome P.; Sammons, Deborah L.; Robertson, Shirley A.; Snawder, John E.

    2015-01-01

    Surface contamination from methamphetamine in meth labs continues to be a problem. We had previously developed a lateral flow assay cassette for field detection of methamphetamine contamination that is commercially available and has been used by a number of groups to assess contamination. This cassette uses the complete disappearance of the test line as an end point for detection of 50 ng/100 cm2 of methamphetamine contamination for surface sampling with cotton swabs. In the present study, we further evaluate the response of the cassettes using an electronic lateral flow reader to measure the intensities of the test and control lines. The cassettes were capable of detecting 0.25 ng/ml for calibration solutions. For 100 cm2 ceramic tiles that were spiked with methamphetamine and wiped with cotton tipped wooden swabs wetted in assay/sampling buffer, 1 ng/tile was detected using the reader. Semi-quantitative results can be produced over the range 0–10 ng/ml for calibration solutions and 0–25 ng/tile for spiked tiles using either a 4-parameter logistic fit of test line intensity versus concentration or spiked mass or the ratio of the control line to the test line intensity fit to concentration or spiked mass. Recovery from the tiles was determined to be about 30% using the fitted curves. Comparison of the control line to the test line was also examined as a possible visual detection end point and it was found that the control line became more intense than the test line at 0.5 to 1 ng/ml for calibration solutions or 1 to 2 ng/tile for spiked tiles. Thus the lateral flow cassettes for methamphetamine have the potential to produce more sensitive semi-quantitative results if an electronic lateral flow reader is used and can be more sensitive for detection if the comparison of the control line to the test line is used as the visual end point. PMID:25379615

  2. Lateral patellofemoral impingement: a cause of treatable pain after TKA.

    PubMed

    Cercek, Robert; Jacofsky, David; Kieffer, Karen; Larsen, Bethany; Jacofsky, Marc

    2011-09-01

    Multiple etiologies may cause anterior knee pain after total knee arthroplasty. While prior studies have addressed component positioning and surgical technique, no series in the literature describes lateral patellofemoral impingement as a source of the pain. Over a 2-year period at our institution, 18 patients with 19 painful total knee arthroplasties were diagnosed with lateral patellofemoral impingement. All underwent revision surgery with either lateral facetectomy or revision of the patellar dome. These patients were followed with Knee Society scores for 1 year. Knee Society scores were significantly improved at 8 weeks, 16 weeks, and 1 year. Lateral patellofemoral impingement should always be considered in the differential diagnosis of the painful total knee arthroplasty. This should be evaluated clinically through direct palpation of the lateral facet, and radiographically with the sunrise view. Lateral facetectomy or patellar revision can be performed with predictably good clinical results.

  3. An in vitro model to investigate filling of lateral canals.

    PubMed

    Venturi, Mauro; Di Lenarda, Roberto; Prati, Carlo; Breschi, Lorenzo

    2005-12-01

    Aims of this work were to examine lateral canals in extracted teeth, to propose a new technique to produce artificial lateral canals, and to compare two obturation techniques. Cleared roots were examined to record measure and shape of lateral canals. Artificial lateral canals were prepared on human demineralized teeth before final clearing. Specimens were divided in two groups: canals of group 1 were filled with Schilder's technique, canals of group 2 were filled with vertical compaction with apical backfilling. Stereomicroscopic analysis of lateral canal filling revealed lower filling rates in apical canals compared to coronal ones and higher filling rates with "vertical compaction with apical backfilling" compared to Schilder's group. The tested procedure appears to be a reliable technique to obtain standardized lateral canals and to compare filling procedures.

  4. Laterality enhances numerical skills in the guppy, Poecilia reticulata.

    PubMed

    Dadda, Marco; Agrillo, Christian; Bisazza, Angelo; Brown, Culum

    2015-01-01

    It has been hypothesized that cerebral lateralization can significantly enhance cognition and that this was one of the primary selective forces shaping its wide-spread evolution amongst vertebrate taxa. Here, we tested this hypothesis by examining the link between cerebral lateralization and numerical discrimination. Guppies, Poecilia reticulata, were sorted into left, right and non-lateralized groups using a standard mirror test and their numerical discrimination abilities tested in both natural shoal choice and abstract contexts. Our results show that strongly lateralized guppies have enhanced numerical abilities compared to non-lateralized guppies irrespective of context. These data provide further credence to the notion that cerebral lateralization can enhance cognitive efficiency. PMID:26578915

  5. Differential bilingual laterality: mythical monster found in Wales.

    PubMed

    Evans, Judith; Workman, Lance; Mayer, Peter; Crowley, Kevin

    2002-11-01

    Paradis (1992) likens studies of bilingual laterality to reported sightings of the Loch Ness Monster, in that although some studies claim differential laterality much conflicting research evidence does not-and like the mythical Scottish monster, what reason have we to suspect that any such phenomenon might exist? This study reexamines differential bilingual laterality using four groups of English-Welsh bilinguals which differ in their age of acquisition and in their environment of acquisition. Using a split visual field paradigm we present evidence which, supports the notion of greater right hemisphere processing in a later learned language. Our findings also suggest the pattern of lateralization in bilinguals is strongly affected by the specific language environment during development such that the shift toward greater right hemisphere involvement for the later learned language will be more pronounced in individuals which are brought up in areas where that language is not regularly heard.

  6. Lateral position detection and control for friction stir systems

    DOEpatents

    Fleming, Paul; Lammlein, David H.; Cook, George E.; Wilkes, Don Mitchell; Strauss, Alvin M.; Delapp, David R.; Hartman, Daniel A.

    2012-06-05

    An apparatus and computer program are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include oscillating the rotary tool laterally with respect to a selected propagation path for the rotating member with respect to the workpiece to define an oscillation path for the rotating member. The methods further include obtaining force signals or parameters related to the force experienced by the rotary tool at least while the rotating member is disposed at the extremes of the oscillation. The force signals or parameters associated with the extremes can then be analyzed to determine a lateral position of the selected path with respect to a target path and a lateral offset value can be determined based on the lateral position. The lateral distance between the selected path and the target path can be decreased based on the lateral offset value.

  7. Lateral position detection and control for friction stir systems

    DOEpatents

    Fleming, Paul; Lammlein, David H.; Cook, George E.; Wilkes, Don Mitchell; Strauss, Alvin M.; Delapp, David R.; Hartman, Daniel A.

    2011-11-08

    Friction stir methods are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include oscillating the rotary tool laterally with respect to a selected propagation path for the rotating member with respect to the workpiece to define an oscillation path for the rotating member. The methods further include obtaining force signals or parameters related to the force experienced by the rotary tool at least while the rotating member is disposed at the extremes of the oscillation. The force signals or parameters associated with the extremes can then be analyzed to determine a lateral position of the selected path with respect to a target path and a lateral offset value can be determined based on the lateral position. The lateral distance between the selected path and the target path can be decreased based on the lateral offset value.

  8. Development and validation of a lateral MREs isolator

    NASA Astrophysics Data System (ADS)

    Xing, Zhi-Wei; Yu, Miao; Fu, Jie; Zhao, Lu-Jie

    2015-02-01

    A novel lateral vibration isolator utilizing magnetorheological elastomers (MREs) with the field-dependent damping and stiffness was proposed in order to improve the adaptive performance. First, soft silicone rubber MREs with a highly adjustable shear storage modulus was fabricated. Then, the lateral MREs isolator was developed with a unique laminated structure of MRE layers and steel plates, which enables to withstand large vertical loads and adapts to the situation of large lateral displacement. Also, the electromagnetic analysis and design employed electromagnetic finite element method (FEM) to optimize magnetic circuit inside the proposed device. To evaluate the effectiveness of the lateral MREs isolator, a series of experimental tests were carried out under various applied magnetic fields. Experimental results show that the proposed MREs isolator can triumphantly change the lateral stiffness and equivalent damping up to 140% and 125%, respectively. This work demonstrates the performance of the designed lateral MREs isolator and its capacity in vibration mitigation for the complex situation.

  9. Laterality enhances numerical skills in the guppy, Poecilia reticulata

    PubMed Central

    Dadda, Marco; Agrillo, Christian; Bisazza, Angelo; Brown, Culum

    2015-01-01

    It has been hypothesized that cerebral lateralization can significantly enhance cognition and that this was one of the primary selective forces shaping its wide-spread evolution amongst vertebrate taxa. Here, we tested this hypothesis by examining the link between cerebral lateralization and numerical discrimination. Guppies, Poecilia reticulata, were sorted into left, right and non-lateralized groups using a standard mirror test and their numerical discrimination abilities tested in both natural shoal choice and abstract contexts. Our results show that strongly lateralized guppies have enhanced numerical abilities compared to non-lateralized guppies irrespective of context. These data provide further credence to the notion that cerebral lateralization can enhance cognitive efficiency. PMID:26578915

  10. 13. TREES ALONG LATERAL SEGMENT AT THE NORTHERN END OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. TREES ALONG LATERAL SEGMENT AT THE NORTHERN END OF LAKE LADORA. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  11. 2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  12. 8. GENERAL VIEW OF LARGE DIVERSION STRUCTURE ON LATERAL WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. GENERAL VIEW OF LARGE DIVERSION STRUCTURE ON LATERAL WEST OF LOWER DERBY LAKE (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  13. 24. CULVERT WITH CONCRETE HEADWALL AND SIDEWALLS CARRYING THE LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. CULVERT WITH CONCRETE HEADWALL AND SIDEWALLS CARRYING THE LATERAL UNDER 8TH AVENUE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  14. 4. SEGMENT OF LATERAL WEST OF C STREET (SECTION 10) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SEGMENT OF LATERAL WEST OF C STREET (SECTION 10) ON THE ROCKY MOUNTAIN ARSENAL (RMA). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  15. 7. SEGMENT OF LATERAL WITH YUCCA ALONG BANKS, SOUTH OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. SEGMENT OF LATERAL WITH YUCCA ALONG BANKS, SOUTH OF 6TH AVENUE (SECTION 10). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  16. Analysis of diode lasers with lateral spatial variations in thickness

    NASA Astrophysics Data System (ADS)

    Streifer, W.; Burnham, R. D.; Scifres, D. R.

    1980-07-01

    Diode lasers with active and/or cladding regions whose thicknesses vary spatially parallel to the p-n junction are analyzed. It is shown that lateral real-refractive-index waveguiding occurs and that a diffusion gradient exists which propels the injected charges into the lasing modal volume. Lateral mode patterns and thresholds are calculated and sensitivity to higher-order lateral mode oscillation is evaluated for various stripe widths and spreading resistances. Results are shown to agree well with experimental data.

  17. Lateral subsurface flow pathways in a semiarid Ponderosa pine hillslope

    NASA Astrophysics Data System (ADS)

    Newman, Brent D.; Campbell, Andrew R.; Wilcox, Bradford P.

    1998-12-01

    The mechanisms controlling lateral subsurface flow in semiarid environments have received relatively little attention despite the fact that lateral subsurface flow can be an important runoff process in these environments. The objective of the current study is to better understand lateral subsurface flow process in semiarid environments. Natural chloride, dissolved organic carbon, and stable isotope (δD and δ18O) tracers were used to investigate the lateral subsurface flow process and the chemical changes that occur as a result of lateral subsurface flow. Observed differences in chemistry between soil matrix water and lateral subsurface flow were large (for example, chloride concentrations in matrix soil water samples were >200 mg/L, compared with only 2 mg/L in lateral subsurface flow samples obtained at the same time). This difference in chemistry is indicative of a two-domain flow system in which macropores conduct lateral subsurface flow that is not in chemical or hydrological equilibrium with the soil matrix. The size of precipitation events appeared to have a strong influence on the variations in old/new water percentages, and examples of both old and new water dominated events were observed. There were also large variations in the chemistry of lateral subsurface flow with time. For example, chloride and dissolved organic carbon concentrations were 10 and 70 times greater, respectively, under saturated conditions than under unsaturated conditions.

  18. Supine vs decubitus lateral patient positioning in vertebral fracture assessment.

    PubMed

    Paggiosi, Margaret Anne; Finigan, Judith; Peel, Nicola; Eastell, Richard; Ferrar, Lynne

    2012-01-01

    In vertebral fracture assessment (VFA), lateral scans are obtained with the patient positioned supine (C-arm densitometers) or lateral decubitus (fixed-arm densitometers). We aimed to determine the impact of positioning on image quality and fracture definition. We performed supine and decubitus lateral VFA in 50 postmenopausal women and used the algorithm-based qualitative method to identify vertebral fractures. We compared the 2 techniques for the identification of fractures (kappa analysis) and compared the numbers of unreadable vertebrae (indiscernible endplates) and vertebrae that were projected obliquely (Wilcoxon matched-pairs signed-rank test). The kappa score for agreement between the VFA techniques (to identify women with vertebral fractures) was 0.84 (95% confidence interval [CI]: 0.68-0.99), and for agreement with fracture assessments made from radiographs, kappa was 0.76 (95% CI: 0.57-0.94) for both supine and decubitus lateral VFA. There were more unreadable vertebrae with supine lateral (48 vertebrae in supine lateral compared with 14 in decubitus lateral; p=0.001), but oblique projection was less common (93 vertebrae compared with 145 in decubitus lateral; p=0.002). We conclude that there were significantly different projection effects with supine and decubitus lateral VFA, but these differences did not influence the identification of vertebral fractures in our study sample.

  19. New tool allows selective multi-lateral re-entry

    SciTech Connect

    1997-05-01

    This article overviews the world`s first application of a downhole tool installed after the drilling and completion of a lateral borehole from a larger backbone casing, to allow future access to the lateral using through-tubing, coiled tubing operations. The system described is based on the Multi Lateral Selective Re-Entry System, or MLR (trademark), supplied by Pressure Control Engineering Ltd. (PCE) of Poole, Dorset, England. Primary equipment used in creating the lateral completion and its tieback to the backbone liner was supplied by Sperry Sun.

  20. 23. VIEW SHOWING SALT RIVER PROJECT CREWS SLIPFORMING LATERAL DURING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. VIEW SHOWING SALT RIVER PROJECT CREWS SLIPFORMING LATERAL DURING REHABILITATION AND BETTERMENT PROGRAM Photographer: unknown. April 1968 - Arizona Canal, North of Salt River, Phoenix, Maricopa County, AZ

  1. Shoreham Railroad Bridge, Former Addison County Railroad (later, Rutland Railroad, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Shoreham Railroad Bridge, Former Addison County Railroad (later, Rutland Railroad, Addison Branch), spanning Lemon Fair River above Richville Pond, west of East Shoreham Road, Shoreham, Addison County, VT

  2. What We Can Learn from Artificial Lateral Line Sensor Arrays.

    PubMed

    Klein, A T; Kaldenbach, F; Rüter, A; Bleckmann, H

    2016-01-01

    The lateral line system of fish is important for many behaviors, including spatial orientation, prey detection, intraspecific communication, and entraining. With aid of the lateral line, fish perceive minute water motions. The smallest sensory unit of the lateral line is the neuromast, which occurs freestanding on the skin and in fluid-filled canals. We have built artificial lateral line canal systems that can be used to measure spatiotemporal flow patterns. Those patterns can, for instance, be used to distinguish between different environments and upstream objects.

  3. Laterality and emotions: visual laterality in the domestic horse (Equus caballus) differs with objects' emotional value.

    PubMed

    De Boyer Des Roches, Alice; Richard-Yris, Marie-Annick; Henry, Séverine; Ezzaouïa, Mohammed; Hausberger, Martine

    2008-06-01

    Lateralization of emotions has received great attention in the last decades, both in humans and animals, but little interest has been given to side bias in perceptual processing. Here, we investigated the influence of the emotional valence of stimuli on visual and olfactory explorations by horses, a large mammalian species with two large monocular visual fields and almost complete decussation of optic fibres. We confronted 38 Arab mares to three objects with either a positive, negative or neutral emotional valence (novel object). The results revealed a gradient of exploration of the 3 objects according to their emotional value and a clear asymmetry in visual exploration. When exploring the novel object, mares used preferentially their right eyes, while they showed a slight tendency to use their left eyes for the negative object. No asymmetry was evidenced for the object with the positive valence. A trend for an asymmetry in olfactory investigation was also observed. Our data confirm the role of the left hemisphere in assessing novelty in horses like in many vertebrate species and the possible role of the right hemisphere in processing negative emotional responses. Our findings also suggest the importance of both hemispheres in the processing positive emotions. This study is, to our knowledge, the first to demonstrate clearly that the emotional valence of a stimulus induces a specific visual lateralization pattern.

  4. Laterality of a second player position affects lateral deviation of basketball shooting.

    PubMed

    Viggiano, Andrea; Chieffi, Sergio; Tafuri, Domenico; Messina, Giovanni; Monda, Marcellino; De Luca, Bruno

    2014-01-01

    Asymmetrically placed visual distractors are known to cause a lateral bias in the execution of a movement directed toward a target. The aim of the present experiment was to verify if the trajectory of the ball and the trajectory of the jump for a basket-shot can be affected by the sole position of a second player, who stays in front of the shooting player in one of three possible positions (centre, left or right) but too far to physically interfere with the shot. Young basketball players were asked to perform 60 shots at 6.25 m from a regular basket, with or without a second player staying in front of them in, alternately, a centre, left or right position. A computerised system measured the angular deviation of the jump direction from the vertical direction and the lateral deviation of the ball trajectory from the midline. The results showed that both the jump direction and the entry position of the ball deviated toward the opposite side from the second player's side; however, these effects were too small to significantly affect the mean goal percentage. This result confirms that some placements of the players can have an effect as visual distractors. Further studies are necessary to find what game conditions can make such distractors harmful for the athletic performance.

  5. 'Lateral elbow tendinopathy' is the most appropriate diagnostic term for the condition commonly referred-to as lateral epicondylitis.

    PubMed

    Stasinopoulos, Dimitrios; Johnson, Mark I

    2006-01-01

    A plethora of terms that have been used to describe lateral epicondylitis including tennis elbow (TE), epicondylalgia, tendonitis, tendinosis and tendinopathy. These terms usually have the prefix extensor or lateral elbow. Lateral elbow tendinopathy seems to be the most appropriate term to use in clinical practice because other terms make reference to inappropriate aetiological, anatomical and pathophysiological terms. The correct diagnostic term is important for the right treatment. PMID:16843614

  6. Explaining left lateralization for words in the ventral occipitotemporal cortex.

    PubMed

    Seghier, Mohamed L; Price, Cathy J

    2011-10-12

    Reading is a uniquely human task and therefore any sign of neuronal activation that is specific to reading is of considerable interest. One intriguing observation is that ventral occipitotemporal (vOT) activation is more strongly left lateralized for written words than other visual stimuli. This has contributed to claims that left vOT plays a special role in reading. Here, we investigated whether left lateralized vOT responses for words were the consequence of visual feature processing, visual word form selectivity, or higher level language processing. Using fMRI in 82 skilled readers, our paradigm compared activation and lateralization for words and nonlinguistic stimuli during different tasks. We found that increased left lateralization for words relative to pictures was the consequence of reduced activation in right vOT rather than increased activation in left vOT. We also found that the determinants of lateralization varied with the subregion of vOT tested. In posterior vOT, lateralization depended on the spatial frequency of the visual inputs. In anterior vOT, lateralization depended on the semantic demands of the task. In middle vOT, lateralization depended on a combination of visual expertise in the right hemisphere and semantics in the left hemisphere. These results have implications for interpreting left lateralized vOT activation during reading. Specifically, left lateralized activation in vOT does not necessarily indicate an increase in left vOT processing but is instead a consequence of decreased right vOT function. Moreover, the determinants of lateralization include both visual and semantic factors depending on the subregion tested. PMID:21994390

  7. Reconstruction of compound loss of lateral malleolus and lateral ankle ligaments with double-bundle Achilles tendon-bone allograft.

    PubMed

    Ko, Dukhwan; Jung, Hong-Geun; Kim, Hyeung-June; Cha, Seung-Han; Nam, Kyoung-Mo

    2014-01-01

    Open ankle fracture, including compound loss of the lateral malleolus, lateral ankle ligaments, and overlying skin, is a severe injury and can result in ankle instability and permanent disability. Treatment of this injury is challenging and requires bone grafting and soft tissue reconstruction. In the present report, we describe a unique reconstruction technique for compound loss of the lateral malleolus, lateral ankle ligaments, and the overlying skin using a double-bundle Achilles tendon-bone allograft combined with a reverse sural fasciocutaneous flap. The patient obtained a stable ankle with nearly full range of motion and displayed satisfactory function during the follow-up period.

  8. Reproducibility of lateral excursive tooth contact in a semi-adjustable articulator depending on the type of lateral guidance.

    PubMed

    Caro, A J; Peraire, M; Martinez-Gomis, J; Anglada, J M; Samsó, J

    2005-03-01

    The purposes of this study were (i) to compare the reproducibility of lateral tooth contacts of casts mounted in a semi-adjustable articulator when condylar guidance was set by different methods and (ii) to assess the margin of error of the variations of condylar guidance without changing lateral tooth contacts, depending on the type of lateral guidance. In subjects with different types of lateral guidance, intraoral lateral tooth contacts identified with occlusal registration strips were compared with those identified by use of a semi-adjustable articulator, setting the condylar guidance in four different ways: using protrusive wax wafers, by axiography and by adding and subtracting 5 degrees from the value of condylar guidance obtained by protrusive wax wafers. Tolerance to variations of condylar guidance without changing lateral tooth contacts was determined by increasing and decreasing the value of condylar guidance until lateral tooth contacts changed. Different ways of setting condylar guidance on a semi-adjustable articulator give rise to different values of condylar guidance in the same subject. The occlusal repercussions of these variations of condylar guidance values depend on the type of lateral guidance. Canine protection had the greatest tolerance to variations in the setting of condylar guidance without changing lateral occlusal contacts.

  9. Cerebral Laterality and Verbal-Performance Discrepancies in Intelligence.

    ERIC Educational Resources Information Center

    Dean, Raymond S.

    1979-01-01

    The cerebral laterality of children with various configurations of verbal-performance discrepancies was inferred with an objective measure of lateral preference using Verbal and Performance IQ scores of the WISC-R. Results were interpreted as lending support to the notion of competition antagonism between cortical hemispheres and a possible…

  10. 40 CFR 31.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Later disallowances and adjustments. 31.51 Section 31.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... GOVERNMENTS After-the-Grant Requirements § 31.51 Later disallowances and adjustments. The closeout of a...

  11. 45 CFR 92.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Later disallowances and adjustments. 92.51 Section 92.51 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION UNIFORM...-the-Grant Requirements § 92.51 Later disallowances and adjustments. The closeout of a grant does...

  12. 29 CFR 1470.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Later disallowances and adjustments. 1470.51 Section 1470.51 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE UNIFORM... Requirements § 1470.51 Later disallowances and adjustments. The closeout of a grant does not affect: (a)...

  13. 36 CFR 1207.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Later disallowances and adjustments. 1207.51 Section 1207.51 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... AND LOCAL GOVERNMENTS After-The-Grant Requirements § 1207.51 Later disallowances and adjustments....

  14. 32 CFR 33.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Later disallowances and adjustments. 33.51 Section 33.51 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND... LOCAL GOVERNMENTS After-The-Grant Requirements § 33.51 Later disallowances and adjustments. The...

  15. 38 CFR 43.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Later disallowances and adjustments. 43.51 Section 43.51 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... GOVERNMENTS After-The-Grant Requirements § 43.51 Later disallowances and adjustments. The closeout of a...

  16. 21 CFR 1403.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Later disallowances and adjustments. 1403.51 Section 1403.51 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY UNIFORM ADMINISTRATIVE REQUIREMENTS... § 1403.51 Later disallowances and adjustments. The closeout of a grant does not affect: (a) The...

  17. Children's Rorschach Scores as Predictors of Later Adjustment.

    ERIC Educational Resources Information Center

    Tuber, Steven B.

    1983-01-01

    Tested the hypothesis that Rorschach measures of object relations and thought organization could help predict later adjustment. Former patients (N=70) at a child residential treatment center were followed up as adults. Object relations measures were found to be effective discriminators and predictors of later rehospitalization for boys. (JAC)

  18. Confessions of a Schoolman--On Dyslexia and Laterality.

    ERIC Educational Resources Information Center

    Leong, Che Kan

    1984-01-01

    The paper relates early work of Samuel Orton on cerebral dominance to current neuropsychological concepts of laterality as reciprocal functions of the two cerebral hemispheres. The genetic-cultural perspectives of laterality and functional asymmetry in relation to learning disorders are discussed. (Author/CL)

  19. Infant Child Care Patterns and Later Ratings of Preschool Behaviors.

    ERIC Educational Resources Information Center

    Park, Kyung Ja; Honig, Alice Sterling

    This study examined (1) the effects of onset of timing for early nonparental care patterns on later child development, and (2) the effects of length of daily enrollment in care on later cognitive attainment and socioemotional behaviors. Preschool teachers rated 105 middle-class children on the Preschool Behavior Questionnaire (PBQ) and the…

  20. Lateral subtalar dislocation: Case report and review of the literature

    PubMed Central

    Veltman, Ewout S; Steller, Ernst JA; Wittich, Philippe; Keizer, Jort

    2016-01-01

    A case of complicated lateral subtalar dislocation is presented and the literature concerning this injury is reviewed. Subtalar joint dislocations are rare and often the result of a high-energy trauma. Complications include avascular necrosis of the talus, infection, posttraumatic osteoarthritis requiring arthrodesis and chronic subtalar instability. Negative prognostic factors include lateral and complicated dislocations, total talar extrusions, and associated fractures. A literature search was performed to identify studies describing outcome after lateral subtalar joint dislocation. Eight studies including fifty patients could be included, thirty out of 50 patients suffered a complicated injury. Mean follow-up was fifty-five months. Ankle function was reported as good in all patients with closed lateral subtalar dislocation. Thirteen out of thirty patients with complicated lateral subtalar joint dislocation developed a complication. Avascular necrosis was present in nine patients with complicated injury. Four patients with complicated lateral subtalar dislocation suffered deep infection requiring treatment with antibiotics. In case of uncomplicated lateral subtalar joint dislocation, excellent functional outcome after closed reduction and immobilization can be expected. In case of complicated lateral subtalar joint dislocation immediate reduction, wound debridement and if necessary (external) stabilisation are critical. Up to fifty percent of patients suffering complicated injury are at risk of developing complications such as avascular talar necrosis and infection. PMID:27672576

  1. What Specific Preschool Math Skills Predict Later Math Achievement?

    ERIC Educational Resources Information Center

    Nguyen, Tutrang; Watts, Tyler W.; Duncan, Greg J.; Clements, Douglas H.; Sarama, Julie; Wolfe, Christopher B.; Spitler, Mary Elaine

    2015-01-01

    The widespread concern about mathematics achievement has drawn extensive research attention to what skills predict later academic achievement. There is clear and consistent evidence that math achievement at school entry is the strongest predictor of later school success and educational attainment. Early childhood math achievement can thus have…

  2. Lateral subtalar dislocation: Case report and review of the literature.

    PubMed

    Veltman, Ewout S; Steller, Ernst Ja; Wittich, Philippe; Keizer, Jort

    2016-09-18

    A case of complicated lateral subtalar dislocation is presented and the literature concerning this injury is reviewed. Subtalar joint dislocations are rare and often the result of a high-energy trauma. Complications include avascular necrosis of the talus, infection, posttraumatic osteoarthritis requiring arthrodesis and chronic subtalar instability. Negative prognostic factors include lateral and complicated dislocations, total talar extrusions, and associated fractures. A literature search was performed to identify studies describing outcome after lateral subtalar joint dislocation. Eight studies including fifty patients could be included, thirty out of 50 patients suffered a complicated injury. Mean follow-up was fifty-five months. Ankle function was reported as good in all patients with closed lateral subtalar dislocation. Thirteen out of thirty patients with complicated lateral subtalar joint dislocation developed a complication. Avascular necrosis was present in nine patients with complicated injury. Four patients with complicated lateral subtalar dislocation suffered deep infection requiring treatment with antibiotics. In case of uncomplicated lateral subtalar joint dislocation, excellent functional outcome after closed reduction and immobilization can be expected. In case of complicated lateral subtalar joint dislocation immediate reduction, wound debridement and if necessary (external) stabilisation are critical. Up to fifty percent of patients suffering complicated injury are at risk of developing complications such as avascular talar necrosis and infection. PMID:27672576

  3. IQ, Fetal Testosterone and Individual Variability in Children's Functional Lateralization

    ERIC Educational Resources Information Center

    Mercure, Evelyne; Ashwin, Emma; Dick, Frederic; Halit, Hanife; Auyeung, Bonnie; Baron-Cohen, Simon; Johnson, Mark H.

    2009-01-01

    Previous event-related potential (ERP) studies have revealed that faces and words show a robust difference in the lateralization of their N170. The present study investigated the development of this differential lateralization in school-age boys. We assessed the potential role of fetal testosterone (FT) level as a factor biasing the prenatal…

  4. Lateral rectus palsy following coronary angiography and percutaneous coronary intervention

    PubMed Central

    Nicholson, Luke; Jones, Ruth; Hughes, David S

    2014-01-01

    We present a rare case of unilateral lateral rectus palsy following an elective coronary angiography and percutaneous coronary intervention in a 78-year-oldwoman. Ophthalmoplegia following coronary angiography is extremely rare and this is the first case of a unilateral lateral rectus palsy following the procedure. PMID:24536054

  5. 14 CFR 23.177 - Static directional and lateral stability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Static directional and lateral stability... Flight Stability § 23.177 Static directional and lateral stability. (a) The static directional stability... stability, as shown by the tendency to raise the low wing in a sideslip, must be positive for all...

  6. 14 CFR 25.177 - Static lateral-directional stability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Static lateral-directional stability. 25... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.177 Static lateral-directional stability. Link to an amendment published at 76 FR 74654, December 1, 2011. (a)-(b) (c)...

  7. 14 CFR 25.177 - Static lateral-directional stability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Static lateral-directional stability. 25... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.177 Static lateral-directional stability. (a) The static directional stability (as shown by the tendency to recover from a...

  8. 14 CFR 23.177 - Static directional and lateral stability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Static directional and lateral stability... Flight Stability § 23.177 Static directional and lateral stability. (a) The static directional stability... stability, as shown by the tendency to raise the low wing in a sideslip, must be positive for all...

  9. 14 CFR 25.177 - Static lateral-directional stability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Static lateral-directional stability. 25... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.177 Static lateral-directional stability. (a) The static directional stability (as shown by the tendency to recover from a...

  10. 14 CFR 25.177 - Static lateral-directional stability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Static lateral-directional stability. 25... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.177 Static lateral-directional stability. (a)-(b) (c) In straight, steady sideslips, the aileron and rudder control movements...

  11. 14 CFR 25.177 - Static lateral-directional stability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Static lateral-directional stability. 25... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.177 Static lateral-directional stability. (a)-(b) (c) In straight, steady sideslips, the aileron and rudder control movements...

  12. Lateral subtalar dislocation: Case report and review of the literature

    PubMed Central

    Veltman, Ewout S; Steller, Ernst JA; Wittich, Philippe; Keizer, Jort

    2016-01-01

    A case of complicated lateral subtalar dislocation is presented and the literature concerning this injury is reviewed. Subtalar joint dislocations are rare and often the result of a high-energy trauma. Complications include avascular necrosis of the talus, infection, posttraumatic osteoarthritis requiring arthrodesis and chronic subtalar instability. Negative prognostic factors include lateral and complicated dislocations, total talar extrusions, and associated fractures. A literature search was performed to identify studies describing outcome after lateral subtalar joint dislocation. Eight studies including fifty patients could be included, thirty out of 50 patients suffered a complicated injury. Mean follow-up was fifty-five months. Ankle function was reported as good in all patients with closed lateral subtalar dislocation. Thirteen out of thirty patients with complicated lateral subtalar joint dislocation developed a complication. Avascular necrosis was present in nine patients with complicated injury. Four patients with complicated lateral subtalar dislocation suffered deep infection requiring treatment with antibiotics. In case of uncomplicated lateral subtalar joint dislocation, excellent functional outcome after closed reduction and immobilization can be expected. In case of complicated lateral subtalar joint dislocation immediate reduction, wound debridement and if necessary (external) stabilisation are critical. Up to fifty percent of patients suffering complicated injury are at risk of developing complications such as avascular talar necrosis and infection.

  13. A Case of Bilateral Permanent Subluxation of the Lateral Meniscus

    PubMed Central

    Sugiki, Tadashi; Inoue, Yutaka

    2016-01-01

    We report a case of bilateral, permanent subluxation of the lateral meniscus. To our knowledge, the present case is the first reported description of bilateral irreducible anterior dislocation of the posterior segment of the lateral meniscus. This disorder is characterized by a flipped meniscus sign of the lateral meniscus on sagittal magnetic resonance images of the knee joint, with no history of trauma or locking symptoms. A detailed examination of serial magnetic resonance images of the lateral meniscus can help differentiate this condition from malformation of the lateral meniscus, that is, a double-layered meniscus. We recommend two-stage treatment for this disorder. First, the knee joint is kept in straight position for 3 weeks after the lateral meniscus is reduced to the normal position. Second, if subluxation of the lateral meniscus recurs, meniscocapsular suture is then performed. Although subluxation of the lateral meniscus without locking symptoms is rare, it is important to be familiar with this condition to diagnose and treat it correctly. PMID:27774328

  14. Phototropism and gravitropism in lateral roots of Arabidopsis

    NASA Technical Reports Server (NTRS)

    Kiss, John Z.; Miller, Kelley M.; Ogden, Lisa A.; Roth, Kelly K.

    2002-01-01

    Gravitropism and, to a lesser extent, phototropism have been characterized in primary roots, but little is known about structural/functional aspects of these tropisms in lateral roots. Therefore, in this study, we report on tropistic responses in lateral roots of Arabidopsis thaliana. Lateral roots initially are plagiogravitropic, but when they reach a length of approximately 10 mm, these roots grow downward and exhibit positive orthogravitropism. Light and electron microscopic studies demonstrate a correlation between positive gravitropism and development of columella cells with large, sedimented amyloplasts in wild-type plants. Lateral roots display negative phototropism in response to white and blue light and positive phototropism in response to red light. As is the case with primary roots, the photoresponse is weak relative to the graviresponse, but phototropism is readily apparent in starchless mutant plants, which are impaired in gravitropism. To our knowledge, this is the first report of phototropism of lateral roots in any plant species.

  15. Two distinct forms of functional lateralization in the human brain.

    PubMed

    Gotts, Stephen J; Jo, Hang Joon; Wallace, Gregory L; Saad, Ziad S; Cox, Robert W; Martin, Alex

    2013-09-01

    The hemispheric lateralization of certain faculties in the human brain has long been held to be beneficial for functioning. However, quantitative relationships between the degree of lateralization in particular brain regions and the level of functioning have yet to be established. Here we demonstrate that two distinct forms of functional lateralization are present in the left vs. the right cerebral hemisphere, with the left hemisphere showing a preference to interact more exclusively with itself, particularly for cortical regions involved in language and fine motor coordination. In contrast, right-hemisphere cortical regions involved in visuospatial and attentional processing interact in a more integrative fashion with both hemispheres. The degree of lateralization present in these distinct systems selectively predicted behavioral measures of verbal and visuospatial ability, providing direct evidence that lateralization is associated with enhanced cognitive ability.

  16. Phototropism and gravitropism in lateral roots of Arabidopsis.

    PubMed

    Kiss, John Z; Miller, Kelley M; Ogden, Lisa A; Roth, Kelly K

    2002-01-01

    Gravitropism and, to a lesser extent, phototropism have been characterized in primary roots, but little is known about structural/functional aspects of these tropisms in lateral roots. Therefore, in this study, we report on tropistic responses in lateral roots of Arabidopsis thaliana. Lateral roots initially are plagiogravitropic, but when they reach a length of approximately 10 mm, these roots grow downward and exhibit positive orthogravitropism. Light and electron microscopic studies demonstrate a correlation between positive gravitropism and development of columella cells with large, sedimented amyloplasts in wild-type plants. Lateral roots display negative phototropism in response to white and blue light and positive phototropism in response to red light. As is the case with primary roots, the photoresponse is weak relative to the graviresponse, but phototropism is readily apparent in starchless mutant plants, which are impaired in gravitropism. To our knowledge, this is the first report of phototropism of lateral roots in any plant species.

  17. Phaseolus vulgaris RbohB functions in lateral root development

    PubMed Central

    Montiel, Jesús; Arthikala, Manoj-Kumar; Quinto, Carmen

    2013-01-01

    Respiratory burst oxidase homologs (RBOHs) catalyze the reduction of oxygen to generate superoxide anion, a kind of reactive oxygen species (ROS). The ROS produced by RBOHs play essential roles in diverse processes, such as root hair development, stomata closure and signaling mechanisms in response to abiotic stimuli and during plant-pathogen interactions. Recently, we found that PvRbohB silencing in transgenic Phaseolus vulgaris roots had a negative impact on lateral root density. In this work, we show that the downregulation of PvRbohB affects both the growth and ROS levels in recently emerged lateral roots. In addition, we found that the PvRbohB promoter was activated during lateral root primordium initiation in the pericycle, and remained active throughout lateral root development. This study identifies RBOHs as potentially important players in lateral root development in P. vulgaris. PMID:23221754

  18. Centrifuge Modeling of Piles Subjected to Lateral Loads

    NASA Astrophysics Data System (ADS)

    Brant, Logan; Ling, Hoe I.

    There are many applications where piles are employed to absorb and deflect lateral impact loads. Structural elements of this type are used to protect infrastructure and are commonly found at marine sites. A series of model tests have been conducted using Columbia University's centrifuge facility to better understand the performance of piles subjected to these loading conditions. A device was designed to install and laterally load single model piles during centrifuge flight. This device uniquely contains two lateral loading systems, one which allows static testing and another appropriate for dynamic tests. This research examines the behavior of tubular steel piles embedded within dry or saturated soil and subjected to varied rates of lateral loading. This investigation provides insight on the contribution of lateral loading rates to the behavior of piles.

  19. High-fat and ketogenic diets in amyotrophic lateral sclerosis.

    PubMed

    Paganoni, Sabrina; Wills, Anne-Marie

    2013-08-01

    Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. Epidemiologic data suggest that malnutrition is a common feature in amyotrophic lateral sclerosis and being overweight or obese confers a survival advantage in this patient population. In amyotrophic lateral sclerosis mouse models, a high-fat diet has been shown to lead to weight gain and prolonged survival. However, little research has been conducted to test whether nutritional interventions might ameliorate the disease course in humans. Here we review the currently available evidence supporting the potential role of dietary interventions as a therapeutic tool for amyotrophic lateral sclerosis. Ultimately, determining whether a high-fat or ketogenic diet could be beneficial in amyotrophic lateral sclerosis will require large randomized, placebo-controlled clinical trials.

  20. Left-Handedness and Language Lateralization in Children

    PubMed Central

    Szaflarski, Jerzy P.; Rajagopal, Akila; Altaye, Mekibib; Byars, Anna W.; Jacola, Lisa; Schmithorst, Vincent J.; Schapiro, Mark B.; Plante, Elena; Holland, Scott K.

    2011-01-01

    This fMRI study investigated the development of language lateralization in left- and right-handed children between 5 and 18 years of age. Twenty-seven left-handed children (17 boys, 10 girls) and 54 age- and gender-matched right-handed children were included. We used functional MRI at 3T and a verb generation task to measure hemispheric language dominance based on either frontal or temporo-parietal regions of interest (ROIs) defined for the entire group and applied on an individual basis. Based on the frontal ROI, in the left-handed group, 23 participants (85%) demonstrated left-hemispheric language lateralization, 3 (11%) demonstrated symmetric activation, and 1 (4%) demonstrated right-hemispheric lateralization. In contrast, 50 (93%) of the right-handed children showed left-hemisphere lateralization and 3 (6%) demonstrated a symmetric activation pattern, while one (2%) demonstrated a right- hemisphere lateralization. The corresponding values for the temporo-parietal ROI for the left-handed children were 18 (67%) left-dominant, 6 (22%) symmetric, 3 (11%) right-dominant and for the right-handed children 49 (91%), 4 (7%), 1 (2%). Left-hemispheric language lateralization increased with age in both groups but somewhat different lateralization trajectories were observed in girls when compared to boys. The incidence of atypical language lateralization in left-handed children in this study was similar to that reported in adults. We also found similar rates of increase in left-hemispheric language lateralization with age between groups (i.e., independent of handedness) indicating the presence of similar mechanisms for language lateralization in left- and right-handed children. PMID:22177775

  1. Far lateral microdiscectomy: a minimally-invasive surgical technique for the treatment of far lateral lumbar disc herniation

    PubMed Central

    Phan, Kevin; Dunn, Alexander E.; Rao, Prashanth J.

    2016-01-01

    Lumbar disc herniation arises when the annulus fibrosus of the vertebral disc fails, thus allowing displacement of the nucleus pulposus and other tissue. The term far lateral is used variably in the literature and usually refers to an extraforaminal displacement in the peridiscal zone peripheral to the sagittal plane of the most lateral part of the pedicle at the same level. Non-surgical treatments of far lateral disc herniation include physical therapy, anti-inflammatory medication, and corticosteroid injections. Where these conservative measures fail, surgical intervention may be required. Several surgical techniques for the treatment of far lateral herniations have been investigated, including total or medial facetectomy, laminectomy, hemilaminectomy, approaches through the pars interarticularis, and lateral approaches between the transverse processes via the intertransverse muscle and ligament. We present our far lateral microdiscectomy technique which involves accessing the nerve root lateral to the foramen through a small paramedian incision and use of an operating microscope. Far lateral microdiscectomy offers the prospect of better long-term results than other surgical techniques because of less extensive muscle dissection and preservation of the integrity of the facet joint.

  2. Far lateral microdiscectomy: a minimally-invasive surgical technique for the treatment of far lateral lumbar disc herniation.

    PubMed

    Phan, Kevin; Dunn, Alexander E; Rao, Prashanth J; Mobbs, Ralph J

    2016-03-01

    Lumbar disc herniation arises when the annulus fibrosus of the vertebral disc fails, thus allowing displacement of the nucleus pulposus and other tissue. The term far lateral is used variably in the literature and usually refers to an extraforaminal displacement in the peridiscal zone peripheral to the sagittal plane of the most lateral part of the pedicle at the same level. Non-surgical treatments of far lateral disc herniation include physical therapy, anti-inflammatory medication, and corticosteroid injections. Where these conservative measures fail, surgical intervention may be required. Several surgical techniques for the treatment of far lateral herniations have been investigated, including total or medial facetectomy, laminectomy, hemilaminectomy, approaches through the pars interarticularis, and lateral approaches between the transverse processes via the intertransverse muscle and ligament. We present our far lateral microdiscectomy technique which involves accessing the nerve root lateral to the foramen through a small paramedian incision and use of an operating microscope. Far lateral microdiscectomy offers the prospect of better long-term results than other surgical techniques because of less extensive muscle dissection and preservation of the integrity of the facet joint. PMID:27683697

  3. Early visual experience influences behavioral lateralization in the guppy.

    PubMed

    Dadda, Marco; Bisazza, Angelo

    2016-09-01

    Individual differences in lateralization of cognitive functions characterize both humans and non-human species. Genetic factors can account for only a fraction of the variance observed and the source of individual variation in laterality remains in large part elusive. Various environmental factors have been suggested to modulate the development of lateralization, including asymmetrical stimulation of the sensory system during ontogeny. In this study, we raised newborn guppies in an asymmetric environment to test the hypothesis that early left-right asymmetries in visual input may affect the development of cerebral asymmetries. Each fish was raised in an impoverished environment but could voluntarily observe a complex scene in a nearby compartment containing a group of conspecifics. Using asymmetric structures, we allowed some subjects to observe the complex scene with the right eye, others with the left eye, and control fish with both eyes. Among asymmetrically stimulated fish, the mirror test revealed eye dominance congruent with the direction of asymmetric stimulation, while controls showed no left-right laterality bias. Interestingly, asymmetric exposure to social stimuli also affected another aspect of visual lateralization-eye preference for scrutinizing a potential predator-but did not influence a measure of motor asymmetry. As the natural environment of guppies is fundamentally asymmetrical, we suggest that unequal left-right stimulation is a common occurrence in developing guppies and may represent a primary source of individual variation in lateralization as well as an efficient mechanism for producing laterality phenotypes that are adapted to local environmental conditions. PMID:27215573

  4. Thermodynamic and kinetic control of the lateral Si wire growth

    SciTech Connect

    Dedyulin, Sergey N. Goncharova, Lyudmila V.

    2014-03-24

    Reproducible lateral Si wire growth has been realized on the Si (100) surface. In this paper, we present experimental evidence showing the unique role that carbon plays in initiating lateral growth of Si wires on a Si (100) substrate. Once initiated in the presence of ≈5 ML of C, lateral growth can be achieved in the range of temperatures, T = 450–650 °C, and further controlled by the interplay of the flux of incoming Si atoms with the size and areal density of Au droplets. Critical thermodynamic and kinetic aspects of the growth are discussed in detail.

  5. 1. HEAD GATE OF THE SAND CREEK LATERAL AT THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. HEAD GATE OF THE SAND CREEK LATERAL AT THE HIGH LINE CANAL ON THE SOUTH END OF THE PEORIA STREET BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  6. 12. CONCRETE LINING ON A CURVING SEGMENT OF THE LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. CONCRETE LINING ON A CURVING SEGMENT OF THE LATERAL NEAR THE NORTHEAST END OF LAKE LADORA (SECTION 2). - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  7. 30. NORTHERN SEGMENT OF THE LATERAL IN THE NORTHWEST QUARTER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. NORTHERN SEGMENT OF THE LATERAL IN THE NORTHWEST QUARTER OF SECTION 25 STRUCTURE PICTURED IN CO-43-A-28. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  8. 11. CONTINUATION OF LATERAL LEAVING THE DIVERSION STRUCTURE WEST OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. CONTINUATION OF LATERAL LEAVING THE DIVERSION STRUCTURE WEST OF LOWER DERBY LAKE (SECTION 2), SHOWING MEASURING GAUGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  9. Lateral Mass Fixation in the Subaxial Cervical Spine.

    PubMed

    Kurd, Mark F; Millhouse, Paul W; Schroeder, Gregory D; Kepler, Christopher K; Vaccaro, Alexander R

    2015-08-01

    The use of lateral mass screws and rods in the subaxial spine has become the standard method of fixation for posterior cervical spine fusions. Multiple techniques have been described for the placement of lateral mass screws, including the Magerl, the Anderson, and the An techniques. While these techniques are all slightly different, the overall goal is to obtain solid bony fixation while avoiding the neurovascular structures. The use of lateral mass screws has been shown to be a safe and effective technique for achieving a posterior cervical fusion.

  10. Wearable sensor network to study laterality of brain functions.

    PubMed

    Postolache, Gabriela B; Girao, Pedro S; Postolache, Octavian A

    2015-08-01

    In the last decade researches on laterality of brain functions have been reinvigorated. New models of lateralization of brain functions were proposed and new methods for understanding mechanisms of asymmetry between right and left brain functions were described. We design a system to study laterality of motor and autonomic nervous system based on wearable sensors network. A mobile application was developed for analysis of upper and lower limbs movements, cardiac and respiratory function. The functionalities and experience gained with deployment of the system are described.

  11. Resume and analysis of NACA lateral control research

    NASA Technical Reports Server (NTRS)

    Weick, F. E.; Jones, R. T.

    1976-01-01

    An analysis of the principal results of recent lateral control research is made. Two things are considered of primary importance in judging the effectiveness of different control devices: The (calculated) banking and yawing motion of a typical small airplane caused by a deflection of the control, and the stick force required to produce this deflection. The report includes a table in which a number of different lateral control devices are compared on these bases. Test flights demonstrated that satisfactory lateral control at high angles of attack depends as much on the retention of stability as on aileron effectiveness.

  12. Lateral thinkers are not so laterally minded: hemispheric asymmetry, interaction, and creativity.

    PubMed

    Lindell, Annukka K

    2011-07-01

    The biological basis of creativity remains a topic of contention. A long-held view suggests that whereas the left hemisphere is intelligent and analytic, the right hemisphere is the source of all creativity. Consequently, activating the right hemisphere should enhance creative thinking, prompting a plethora of popular books hawking a right hemisphere solution to topics ranging from drawing, to money management, to sex. More recently, an alternate proposal has suggested that creativity is not a lateralised function; instead, creativity is argued to stem from the interaction and integration of information across both the left and right hemispheres. According to this view, individuals with greater interhemispheric communication and/or less-lateralised brains will evidence enhanced creative ability. This paper reviews the neural basis of creativity to determine whether creativity stems from activation of the right hemisphere, or from the interaction of both hemispheres. The relationship between creativity and psychopathology is also examined, evaluating the evidence for a causal link between disorders such as schizophrenia, hemispheric activation, and enhanced creativity. Although the research reviewed indicates greater right hemisphere activity during creative tasks, the interaction between many varied, often distant, cortical regions across both the left and right hemispheres is also a crucial component of creativity. This interaction facilitates the integration of a variety of separate cognitive abilities, fostering creative thinking. As such, creativity is better conceptualised as a distributed, rather than a purely lateralised, function; more lateral thinkers have less lateralised brains.

  13. Laterality and mental disorders in the postgenomic age--A closer look at schizophrenia and language lateralization.

    PubMed

    Ocklenburg, Sebastian; Güntürkün, Onur; Hugdahl, Kenneth; Hirnstein, Marco

    2015-12-01

    Most people are right-handed and show left-hemispheric language lateralization, but a minority exhibits left-handedness and right-hemispheric language lateralization. This atypical laterality pattern is observed significantly more often in schizophrenia patients than in the general population, which led several authors to conclude that there is a genetic link between laterality and schizophrenia. It has even been suggested that a failure in the lateralization process, orchestrated by genes, could be the primary cause of schizophrenia. However, the molecular genetic evidence for a link between laterality and schizophrenia is weak. Recent genetic evidence indicates that schizophrenia is not a single disorder but a group of heritable disorders caused by different genotypic networks leading to distinct clinical symptoms. To uncover the link between schizophrenia and laterality we therefore suggest a paradigm shift where genetics are not mapped on schizophrenia as a whole but on discrete schizophrenia symptoms. In addition, we provide a critical evaluation of current theories on the genetic link between schizophrenia and brain asymmetry.

  14. 13. VIEW OF LOG BRIDGE (LATER SUPERSEDED BY THE WIREROPE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. VIEW OF LOG BRIDGE (LATER SUPERSEDED BY THE WIRE-ROPE SUSPENSION BRIDGE), SHOWING OVERHANG WHERE ROCK WAS BLASTED OUT, LOOKING NORTHEAST - Goat Trail Mining Road, Highway 20, 1.5 miles North of Newhalem, Newhalem, Whatcom County, WA

  15. 14. VIEW OF LOG BRIDGE (LATER SUPERSEDED BY THE WIREROPE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. VIEW OF LOG BRIDGE (LATER SUPERSEDED BY THE WIRE-ROPE SUSPENSION BRIDGE), SHOWING OVERHANG WHERE ROCK WAS BLASTED OUT, LOOKING SOUTHWEST - Goat Trail Mining Road, Highway 20, 1.5 miles North of Newhalem, Newhalem, Whatcom County, WA

  16. "Cheese" room in halfcellar showing stone trough, later fireplace supports, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    "Cheese" room in half-cellar showing stone trough, later fireplace supports, stairs inserted in original relieving arch. - Scheetz Farm, House, 7161 Camp Hill Road, Fort Washington, Montgomery County, PA

  17. Lateral crural repositioning for treatment of cephalic malposition.

    PubMed

    Toriumi, Dean M; Asher, Scott A

    2015-02-01

    After completion of this article, the reader should be able to describe the indications for lateral crural repositioning, understand the key steps to performing the procedure, and be able to manage the complications associated with this treatment strategy. PMID:25430928

  18. 13. DETAIL, LATERAL BRACING FOR INTERIOR OVERHEAD CRANE Delaware, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. DETAIL, LATERAL BRACING FOR INTERIOR OVERHEAD CRANE - Delaware, Lackawanna & Western Railroad Freight & Rail Yard, Multiple Unit Light Inspection Shed, New Jersey Transit Hoboken Terminal Rail Yard, Hoboken, Hudson County, NJ

  19. 51. photocopy of Indian figure which later was mounted on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. photocopy of Indian figure which later was mounted on Tower. Photograph taken at Tacony Iron and Metal Co. works, c. 1892. PCA - The New Public Buildings, Penn Square, Broad & Market Streets, Philadelphia, Philadelphia County, PA

  20. Antenna cab interior showing waveguide from external parabolic antenna (later ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Antenna cab interior showing waveguide from external parabolic antenna (later addition), looking north. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

  1. Detail, external parabolic antenna (later addition). Note how waveguide was ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, external parabolic antenna (later addition). Note how waveguide was cut to remove active portion of antenna. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

  2. Overall view with ditch lateral, looking north Thomas Murphy ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Overall view with ditch lateral, looking north - Thomas Murphy Homestead, North of John Moulton Homestead, approximately 1,000 feet west of Mormon Row Road, and .25 mile north of Antelope Flats Road, Kelly, Teton County, WY

  3. 9. DETAIL VIEW OF SUPPORT COLUMNS AND LATERAL BRACINGS INSIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL VIEW OF SUPPORT COLUMNS AND LATERAL BRACINGS INSIDE CUPOLA - Baltimore & Ohio Railroad, Mount Clare Passenger Car Shop, Southwest corner of Pratt & Poppleton Streets, Baltimore, Independent City, MD

  4. 10. EYEBAR PIN CONNECTION JOINING VERTICAL SUSPENSION STRINGER WITH LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. EYEBAR PIN CONNECTION JOINING VERTICAL SUSPENSION STRINGER WITH LATERAL BRACING MEMBERS - Spruce Street Bridge, East Spruce Street, 500 Block, spanning Power Canal, Sault Ste. Marie, Chippewa County, MI

  5. 11. Detail of sway braces, struts and top lateral braces' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Detail of sway braces, struts and top lateral braces' view to north-northwest - Milk River Bridge, Spanning Milk River approximately one mile north of Tampico on Tampico North Road, Tampico, Valley County, MT

  6. The effect of lateral interaction on traffic flow

    NASA Astrophysics Data System (ADS)

    Bouadi, M.; Jetto, K.; Benyoussef, A.; Kenz, A.

    2016-10-01

    We propose an extended cellular automaton model for traffic flow, taking into account lateral interactions with defects and between vehicles. The fundamental diagram for a given defects density on the road is studied. It is found that the plateau size increases linearly with the decreasing road width for little defects densities. Furthermore, the capacity increases linearly with the increasing road width. However, for a fixed road width, the capacity decreases exponentially with the increasing defects density. The lateral effects for non-mutual interactions between lanes and for the same maximal velocity is also investigated. It is found that the lateral effects on one lane are meaningful only when the density on the other lane is above the critical density. However, the lateral effects are always present if fast and slow lanes exist. Little differences have been found for the mutual interactions.

  7. Design of lateral heterostructure from arsenene and antimonene

    NASA Astrophysics Data System (ADS)

    Sun, Qilong; Dai, Ying; Ma, Yandong; Yin, Na; Wei, Wei; Yu, Lin; Huang, Baibiao

    2016-09-01

    Lateral heterostructures fabricated by two-dimensional building blocks have opened up exciting realms in material science and device physics. Identifying suitable materials for creating such heterostructures is urgently needed for the next-generation devices. Here, we demonstrate a novel type of seamless lateral heterostructures with excellent stabilities formed within pristine arsenene and antimonene. We find that these heterostructures could possess direct and reduced energy gaps without any modulations. Moreover, the highly coveted type-II alignment and the high carrier mobility are also identified, marking the enhanced quantum efficiency. The tensile strain can result in efficient bandgap engineering. Besides, the proposed critical condition for favored direct energy gaps would have a guiding significance on the subsequent works. Generally, our predictions not only introduce new vitality into lateral heterostructures, enriching available candidate materials in this field, but also highlight the potential of these lateral heterostructures as appealing materials for future devices.

  8. 7. DETAIL OF LATERAL BRACING OF THROUGH TRUSS SPAN (THIS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. DETAIL OF LATERAL BRACING OF THROUGH TRUSS SPAN (THIS SPAN IS IMMEDIATELY SOUTH OF THE VERTICAL LIFT SPAN). - Shippingsport Bridge, Spanning Illinois River at State Route 51, La Salle, La Salle County, IL

  9. 7. VIEW OF SOUTHERN PACIFIC RAILROAD BRIDGE, LOWER CHORD, LATERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF SOUTHERN PACIFIC RAILROAD BRIDGE, LOWER CHORD, LATERAL BRACING AND FLOOR SYSTEM, LOOKING WEST. - Southern Pacific Railroad Bridge, Spanning Rio Grande at Southern Pacific Railroad, El Paso, El Paso County, TX

  10. Lateral boundary conditions for the Klein-Gordon-Fock equation

    NASA Astrophysics Data System (ADS)

    Tulenov, Kanat S.; Dauitbek, Dostilek

    2016-08-01

    In this paper we consider an initial-boundary value problem for the Klein-Gordon-Fock equation. We prove the uniqueness of the solution and find lateral boundary conditions for the Klein-Gordon-Fock equation.

  11. Detail view, looking west from eastern pier, showing stringers, lateral ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail view, looking west from eastern pier, showing stringers, lateral bracing and turnbuckles. - Monongahela Railroad, New Geneva Bridge, Spanning Monongahela River, South of Lock & Dam No. 7, New Geneva, Fayette County, PA

  12. 22. Top Lateral Bracing & Top Chord, Vertical Tension Member ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Top Lateral Bracing & Top Chord, Vertical Tension Member 6, end Vertical Compression Members 5 & 4; South Swing Span; looking N. - Pacific Shortline Bridge, U.S. Route 20,spanning Missouri River, Sioux City, Woodbury County, IA

  13. Amyotrophic lateral sclerosis: early contributions of Jean-Martin Charcot.

    PubMed

    Goetz, C G

    2000-03-01

    Amyotrophic lateral sclerosis is historically an important entity because its manifestations involve distinct signs that can be correlated with gray and white matter lesions at specific sites within the central nervous system. Working at the end of the nineteenth century, the celebrated neurologist, Jean-Martin Charcot, used this disorder as a prototypic example of the power of his research method, termed "méthode anatomoclinique." Using clinical cases and autopsy material, he showed how anatomical lesions in the nervous system could be accurately determined by the presence of carefully analyzed clinical signs. Charcot's work on amyotrophic lateral sclerosis brought together neurological entities formerly considered as disparate disorders, primary amyotrophy and primary lateral sclerosis. In addition, these studies contributed to the understanding of spinal cord and brain stem anatomy and the organization of the normal nervous system. Because of Charcot's fundamental contributions, the eponym "Charcot's disease" has been used internationally in association with amyotrophic lateral sclerosis.

  14. Blood Pressure Problems During Pregnancy, Heart Trouble Later?

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_159580.html Blood Pressure Problems During Pregnancy, Heart Trouble Later? Spotting risk ... 2016 (HealthDay News) -- Pregnant women who have blood pressure in the high-normal range may have an ...

  15. East side detail, showing later wings flanking original entrance on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    East side detail, showing later wings flanking original entrance on east side. - Fitzsimons General Hospital, Red Cross Building, South Eighth Street Bounded by West McAfee Avenue on South & West Harlow Avenue on North, Aurora, Adams County, CO

  16. Discomfort during lateral acceleration: influence of seat cushion and backrest.

    PubMed

    Beard, George F; Griffin, Michael J

    2013-07-01

    Lateral acceleration causes discomfort but how the discomfort depends on the frequency of acceleration or characteristics of seating is poorly understood. Using magnitude estimation, twelve male subjects rated the discomfort caused by lateral oscillation at eight frequencies (0.2-1.0 Hz) across four seating conditions (a rigid seat and a train seat, both with and without backrests). Discomfort increased with increasing frequency of lateral acceleration in a similar manner for all four seating conditions. However, at all frequencies and with both seats there was less discomfort when sitting with backrest support than without. Least discomfort occurred on the train seat with backrest and greatest discomfort on the rigid seat without backrest. Current standards predict an additive effect of backrest on vibration discomfort, but the findings show that low frequency lateral acceleration can cause less discomfort when sitting with a backrest than when sitting on the same seat without a backrest.

  17. Lateral flow based immunobiosensors for detection of food contaminants.

    PubMed

    Raeisossadati, Mohammad Javad; Danesh, Noor Mohammad; Borna, Fazlollah; Gholamzad, Mehrdad; Ramezani, Mohammad; Abnous, Khalil; Taghdisi, Seyed Mohammad

    2016-12-15

    Safety of food is of great concern these days due to various contaminations including toxins, infectious agents and chemical contaminants. Therefore, there is a need to develop promising and user's friendly method to monitor food safety. Lateral flow tests are new, simple and rapid alternative for detection of food-borne pathogens compared with traditional methods. In this review article, we surveyed application of lateral flow biosensors in detection of different food contaminants and labels used to enhance the efficiency of the system. Finally, the unique feature of multi-parametric analysis of analytes by lateral flow device has been reported, proving a lateral flow system is able to be designed in a way to detect multiple targets, simultaneously. PMID:27376194

  18. Distant touch hydrodynamic imaging with an artificial lateral line.

    PubMed

    Yang, Yingchen; Chen, Jack; Engel, Jonathan; Pandya, Saunvit; Chen, Nannan; Tucker, Craig; Coombs, Sheryl; Jones, Douglas L; Liu, Chang

    2006-12-12

    Nearly all underwater vehicles and surface ships today use sonar and vision for imaging and navigation. However, sonar and vision systems face various limitations, e.g., sonar blind zones, dark or murky environments, etc. Evolved over millions of years, fish use the lateral line, a distributed linear array of flow sensing organs, for underwater hydrodynamic imaging and information extraction. We demonstrate here a proof-of-concept artificial lateral line system. It enables a distant touch hydrodynamic imaging capability to critically augment sonar and vision systems. We show that the artificial lateral line can successfully perform dipole source localization and hydrodynamic wake detection. The development of the artificial lateral line is aimed at fundamentally enhancing human ability to detect, navigate, and survive in the underwater environment.

  19. DETAIL OF ORIGINAL DOOR (LOUVERS ADDED LATER) ON THE SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF ORIGINAL DOOR (LOUVERS ADDED LATER) ON THE SOUTH SIDE. VIEW FACING NORTH-NORTHWEST. - U.S. Naval Base, Pearl Harbor, Aviation Storehouse, Vincennes Avenue at Simms Street, Pearl City, Honolulu County, HI

  20. Two clinical tests for assessing lateral compartment arthritis.

    PubMed

    Shakespeare, David

    2006-08-01

    Two clinical tests, the valgus tap test and the valgus skid test, are described which detect bone contact in the lateral compartment of the knee. They are useful in planning surgical intervention. PMID:16632364

  1. 22. TEMPORARY CENTRIFIGAL PUMP. NOTE CHAPMAN HYDRAULICOPERATED VALVE FOR LATER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. TEMPORARY CENTRIFIGAL PUMP. NOTE CHAPMAN HYDRAULIC-OPERATED VALVE FOR LATER CONNECTION OF ENGINE PUMP END TO DISCHARGE HEADER. - Lakeview Pumping Station, Clarendon & Montrose Avenues, Chicago, Cook County, IL

  2. 23. TEMPORARY CENTRIFUGAL PUMP. NOTE CHAPMAN HYDRAULICOPERATED VALVE FOR LATER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. TEMPORARY CENTRIFUGAL PUMP. NOTE CHAPMAN HYDRAULIC-OPERATED VALVE FOR LATER CONNECTION OF ENGINE PUMP ENG TO DISCHARGE HEADER. - Lakeview Pumping Station, Clarendon & Montrose Avenues, Chicago, Cook County, IL

  3. 11. VIEW OF SOUTH BRIDGE PIER, BOTTOM LATERAL BRACING, LOWER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW OF SOUTH BRIDGE PIER, BOTTOM LATERAL BRACING, LOWER CHORD, STRINGERS, END POST AND BEARING SEAT; FACING SOUTHEAST. - Walker Bridge, Spanning Klamath River and connecting Highway 96 and Walker Road, Klamath River, Siskiyou County, CA

  4. 38. VIEW LOOKING SOUTH, LATERAL ELEVATION OF CARETAKER'S COTTAGE FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. VIEW LOOKING SOUTH, LATERAL ELEVATION OF CARETAKER'S COTTAGE FROM ENTRANCE HOUSE TERRACE (4' x 5' negative) - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  5. 6. Tempe Crosscut Canal, looking west from Division Gates. Lateral ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Tempe Crosscut Canal, looking west from Division Gates. Lateral at left is for local delivery of irrigation water. Photographer: Mark Durben, February 1989. Source: SRPA - Tempe Canal, South Side Salt River in Tempe, Mesa & Phoenix, Tempe, Maricopa County, AZ

  6. 9. VIEW OF LATERAL GATE ON CANAL NEAR DAM, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. VIEW OF LATERAL GATE ON CANAL NEAR DAM, LOOKING SOUTHEAST - High Mountain Dams in Upalco Unit, Twin Pots Dam, Ashley National Forest, 10.1 miles North of Mountain Home, Mountain Home, Duchesne County, UT

  7. 20. WEB / DECK / LATERAL BRACING DETAIL OF THROUGH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. WEB / DECK / LATERAL BRACING DETAIL OF THROUGH TRUSSES. VIEW TO WEST. - Abraham Lincoln Memorial Bridge, Spanning Missouri River on Highway 30 between Nebraska & Iowa, Blair, Washington County, NE

  8. Absence of the lateral and third ventricles associated with holoprosencephaly

    PubMed Central

    Ciftcioglu, Engin; Ozyurek, Hamit; Nural, Mehmet Selim; Incesu, Lutfi; Ogur, Gonul

    2015-01-01

    We describe a 6-month-old boy suffering from motor and mental retardation. All radiological features were suggestive of holoprosencephaly with no identifiable lateral or third ventricles and fusion of the thalami. PMID:26417484

  9. Lateral blasts at Mount St. Helens and hazard zonation

    USGS Publications Warehouse

    Crandell, D.R.; Hoblitt, R.P.

    1986-01-01

    Lateral blasts at andesitic and dacitic volcanoes can produce a variety of direct hazards, including ballistic projectiles which can be thrown to distances of at least 10 km and pyroclastic density flows which can travel at high speed to distances of more than 30 km. Indirect effect that may accompany such explosions include wind-borne ash, pyroclastic flows formed by the remobilization of rock debris thrown onto sloping ground, and lahars. Two lateral blasts occurred at a lava dome on the north flank of Mount St. Helens about 1200 years ago; the more energetic of these threw rock debris northeastward across a sector of about 30?? to a distance of at least 10 km. The ballistic debris fell onto an area estimated to be 50 km2, and wind-transported ash and lapilli derived from the lateral-blast cloud fell on an additional lobate area of at least 200 km2. In contrast, the vastly larger lateral blast of May 18, 1980, created a devastating pyroclastic density flow that covered a sector of as much as 180??, reached a maximum distance of 28 km, and within a few minutes directly affected an area of about 550 km2. The May 18 lateral blast resulted from the sudden, landslide-induced depressurization of a dacite cryptodome and the hydrothermal system that surrounded it within the volcano. We propose that lateral-blast hazard assessments for lava domes include an adjoining hazard zone with a radius of at least 10 km. Although a lateral blast can occur on any side of a dome, the sector directly affected by any one blast probably will be less than 180??. Nevertheless, a circular hazard zone centered on the dome is suggested because of the difficulty of predicting the direction of a lateral blast. For the purpose of long-term land-use planning, a hazard assessment for lateral blasts caused by explosions of magma bodies or pressurized hydrothermal systems within a symmetrical volcano could designate a circular potential hazard area with a radius of 35 km centered on the volcano

  10. Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis.

    PubMed

    Vercruysse, Pauline; Sinniger, Jérôme; El Oussini, Hajer; Scekic-Zahirovic, Jelena; Dieterlé, Stéphane; Dengler, Reinhard; Meyer, Thomas; Zierz, Stephan; Kassubek, Jan; Fischer, Wilhelm; Dreyhaupt, Jens; Grehl, Torsten; Hermann, Andreas; Grosskreutz, Julian; Witting, Anke; Van Den Bosch, Ludo; Spreux-Varoquaux, Odile; Ludolph, Albert C; Dupuis, Luc

    2016-04-01

    Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from major defects in energy metabolism, such as weight loss, which are well correlated with survival. Indeed, nutritional intervention targeting weight loss might improve survival of patients. However, the neural mechanisms underlying metabolic impairment in patients with amyotrophic lateral sclerosis remain elusive, in particular due to the lack of longitudinal studies. Here we took advantage of samples collected during the clinical trial of pioglitazone (GERP-ALS), and characterized longitudinally energy metabolism of patients with amyotrophic lateral sclerosis in response to pioglitazone, a drug with well-characterized metabolic effects. As expected, pioglitazone decreased glycaemia, decreased liver enzymes and increased circulating adiponectin in patients with amyotrophic lateral sclerosis, showing its efficacy in the periphery. However, pioglitazone did not increase body weight of patients with amyotrophic lateral sclerosis independently of bulbar involvement. As pioglitazone increases body weight through a direct inhibition of the hypothalamic melanocortin system, we studied hypothalamic neurons producing proopiomelanocortin (POMC) and the endogenous melanocortin inhibitor agouti-related peptide (AGRP), in mice expressing amyotrophic lateral sclerosis-linked mutant SOD1(G86R). We observed lower Pomc but higher Agrp mRNA levels in the hypothalamus of presymptomatic SOD1(G86R) mice. Consistently, numbers of POMC-positive neurons were decreased, whereas AGRP fibre density was elevated in the hypothalamic arcuate nucleus of SOD1(G86R) mice. Consistent with a defect in the hypothalamic melanocortin system, food intake after short term fasting was increased in SOD1(G86R) mice. Importantly, these findings were replicated in two other amyotrophic

  11. The Importance of the Upper Lateral Cartilage in Rhinoplasty.

    PubMed

    Rohrich, Rod J; Pulikkottil, Benson J; Stark, Ran Y; Amirlak, Bardia; Pezeshk, Ronnie A

    2016-02-01

    The upper lateral cartilages are instrumental in obtaining optimal outcomes in aesthetic and functional rhinoplasty. Knowledgeable manipulation of the upper lateral cartilages can take advantage of the crucial malleable parameters of projection, width, nasal dorsal shape, and tip rotation. A lucid understanding of the anatomical intricacies in this portion of the cartilaginous framework permits the surgeon to use their unique characteristics to consistently achieve the desired results. PMID:26818282

  12. Laterally injected light-emitting diode and laser diode

    SciTech Connect

    Miller, Mary A.; Crawford, Mary H.; Allerman, Andrew A.

    2015-06-16

    A p-type superlattice is used to laterally inject holes into an III-nitride multiple quantum well active layer, enabling efficient light extraction from the active area. Laterally-injected light-emitting diodes and laser diodes can enable brighter, more efficient devices that impact a wide range of wavelengths and applications. For UV wavelengths, applications include fluorescence-based biological sensing, epoxy curing, and water purification. For visible devices, applications include solid state lighting and projection systems.

  13. [Nonsurgical retreatment of lateral radiopacity after surgical treatment].

    PubMed

    Arias de Luxan, A

    1990-01-01

    A case report is presented of an upper central incisor with incomplete endodontic procedure evidencing a radiolucent image that was treated by apicoectomy and retroamalgam. A year later the periapical lesion had healed completely but a new lateral radiolucency is observed. A reentry of the canal is performed eliminating the old obturating material, biomechanical preparation and obturation with sealer and thermo gutta-percha. The lesion was cured in nine months.

  14. [Operative treatment of lateral hyperpressure syndrome of the patella].

    PubMed

    Franke, J; Riede, D; Rudolph, F

    1980-04-01

    The lateral hyperpressure syndrome of the patella according to Ficat is characterized as a main cause of chondropathia patellae. Symptoms and course as well as roentgenology of this syndrome are illustrated. The logical method of treatment of this syndrome is the lateral release-operation according to Viernstein and Weigert. With this operation we gained good and very good results in 77 per cent of the 30 operated knee-joints.

  15. Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  16. Lateral Stress Measurements in Pure Tungsten during Shock Loading

    SciTech Connect

    Millett, J. C. F.; Gray, G. T. III; Bourne, N. K.

    2006-07-28

    Longitudinal and lateral stresses during the shock loading of pure tungsten have been measured using manganin stress gauges. The Hugoniot has been compared to the previous work of others and shown to be in close agreement. Lateral stresses have been shown to increase behind the shock front, implying that the shear strength decreases. Whilst this is similar to results in tantalum, comparison with recovery experiments in the literature suggests that this may be due in part to a brittle failure process.

  17. Lateral epicondylitis in tennis: update on aetiology, biomechanics and treatment

    PubMed Central

    De Smedt, Thomas; de Jong, Andy; Van Leemput, Wim; Lieven, Dossche; Van Glabbeek, Francis

    2007-01-01

    Lateral epicondylitis (tennis elbow) is the most frequent type of myotendinosis and can be responsible for substantial pain and loss of function of the affected limb. Tennis biomechanics, player characteristics and equipment are important in preventing the condition. This article presents an overview of the current knowledge on lateral epicondylitis, and focuses on treatment strategies. Conservative and surgical treatment options are discussed, and recent techniques are outlined. PMID:17616547

  18. Polarization anisotropic luminescence of tunable single lateral quantum dot molecules

    NASA Astrophysics Data System (ADS)

    Hermannstädter, C.; Witzany, M.; Heldmaier, M.; Hafenbrak, R.; Jöns, K. D.; Beirne, G. J.; Michler, P.

    2012-03-01

    We investigate the photoluminescence polarization anisotropy of self-assembled individual lateral InGaAs/GaAs quantum dot molecules. In contrast to similarly grown single quantum dots, the dot molecules exhibit a remarkable degree of linear polarization, which remains almost unchanged when a lateral electric field is applied to tune the exciton wave function and, thus, the luminescence spectral properties. We discuss the nature of this polarization anisotropy and suggest possible causes based on the system's symmetry and heterostructure alloy composition.

  19. [Nonsurgical retreatment of lateral radiopacity after surgical treatment].

    PubMed

    Arias de Luxan, A

    1990-01-01

    A case report is presented of an upper central incisor with incomplete endodontic procedure evidencing a radiolucent image that was treated by apicoectomy and retroamalgam. A year later the periapical lesion had healed completely but a new lateral radiolucency is observed. A reentry of the canal is performed eliminating the old obturating material, biomechanical preparation and obturation with sealer and thermo gutta-percha. The lesion was cured in nine months. PMID:1964068

  20. [Failure in anterior rehabilitation of agenesic maxillary lateral incisors].

    PubMed

    Le Gall, Michel; Philippart-Rochaix, Martine; Philip-Alliez, Camille

    2016-03-01

    Agenesis of the maxillary lateral incisors poses particular problems for dentists, orthodontists and patients. Treatment of these ageneses is still highly controversial, both functionally and esthetically. The patient's smile and anterior guidance are affected and must be restored. The diagnosis is easy. Few mistakes are possible. However, managing patients with missing maxillary lateral incisors can be a challenge, commonly involving two possible treatment approaches: space opening to replace the missing lateral incisor with a prosthetic unit (denture, bridge or implant) or orthodontic space closure replacing the missing lateral incisor with the maxillary canine camouflaged to mimic the appearance of a lateral incisor. One of these two options will be adopted using multiple means...liable to trigger a multitude of possible errors. Ultimately, optimal results can only be achieved if there is excellent coordination between different practitioners in various specialties. Each clinician will have a specific role to play. Also, the patient and family are at the heart of the decision-making process, by virtue of their consent (treatment duration, financial resources) and their motivation. This multi-factorial, multi-disciplinary decision process means that treatment of the lateral incisor is an ongoing challenge for the clinician striving for the best possible result. Each case is different. No set rules exist. No single factor can be neglected if we are to avoid "failure". PMID:27083223

  1. Masticatory laterality--evaluation and influence of food texture.

    PubMed

    Mizumori, T; Tsubakimoto, T; Iwasaki, M; Nakamura, T

    2003-10-01

    The purpose of this study is the objective and quantitative evaluation of masticatory laterality and its daily variability. Various foods with different textures were used to investigate whether food texture influenced masticatory laterality. Ten healthy subjects and seven foods were used. Recordings of chewing movements were repeated three times at intervals of 1 week. Masticatory laterality was assessed with an Asymmetry Index [AI: (number of right side strokes - number of left side strokes)/number of total strokes]. Medians and ranges of the three recordings were calculated. The observed AI ranges in the three trials were limited with the exception of two subjects. Among the other subjects, averages of the absolute values of the medians were from 32.5 to 73.4%. Statistically significant differences between the hardest food and softer foods were observed in absolute value of AI medians. Masticatory laterality could be evaluated by an AI. Eight of 10 subjects showed limited ranges of AI in three recordings. It should be noted that a few people actually chew on either side but might chew on one side only on a particular day. Hard food evoked more masticatory laterality, and seemed more appropriate for laterality examinations.

  2. Lateral line canal morphology and signal to noise ratio

    NASA Astrophysics Data System (ADS)

    Klein, Adrian; Herzog, Hendrik; Bleckmann, Horst

    2011-04-01

    The lateral line system of fish is important for many behaviors, including spatial orientation, prey detection, shoaling, intra specific communication and entraining. The smallest sensory unit of the lateral line is the neuromast that occurs free standing on the skin and in fluid filled canals. With aid of the lateral line fish perceive minute water motions. In their natural habitat fish are not only faced with biotic water motion but also with the abiotic fluctuations caused by various inanimate sources. The detection of meaningful signals is crucial for survival, and therefore animals should be able to separate meaningful signals from noise. Fishes live in various habitats (e.g. in still water or in running water). Therefore it is not surprising that the number and distribution of neuromasts as well as canal dimension, canal shape and canal branching patterns differ among fish species. We studied how lateral line canal parameters influence the filter properties of lateral line canals. To do so we exposed artificial lateral line canals, equipped with artificial neuromasts (sensors), to the vortex street shed by a submerged cylinder and to air bubble noise. We found that certain canal parameters significantly can enhance the signal to noise ratio.

  3. Extra-articular Mimickers of Lateral Meniscal Tears

    PubMed Central

    Barker, Joseph U.; Strauss, Eric J.; Lodha, Sameer; Bach, Bernard R.

    2011-01-01

    Context: Lateral meniscus tears are a common entity seen in sports medicine. Although lateral-side knee pain is often the result of a meniscus injury, several extra-articular pathologies share signs and symptoms with a meniscus tear. It is critical for the clinician to be able to identify and understand extra-articular pathologies that can present similar to a lateral meniscus tear. Evidence Acquisition: Data were collected through a thorough review of the literature conducted through a MEDLINE search for all relevant articles between 1980 and February 2010. Study Type: Clinical review. Results: Common extra-articular pathologies that can mimic lateral meniscal tears include iliotibial band syndrome, proximal tibiofibular joint instability, snapping biceps femoris or popliteus tendons, and peroneal nerve compression syndrome or neuritis. The patient history, physical examination features, and radiographic findings can be used to separate these entities from the more common intra-articular knee pathologies. Conclusions: In treating patients who present with lateral-sided knee pain, clinicians should be able to recognize and treat extra-articular pathologies that can present in a similar fashion as lateral meniscus tears. PMID:23015995

  4. Lateral cervical sinus: specific sonographic findings in two pediatric cases.

    PubMed

    Hosokawa, Takahiro; Yamada, Yoshitake; Sato, Yumiko; Tanami, Yutaka; Amano, Hizuru; Fujiogi, Michimasa; Kawashima, Hiroshi; Oguma, Eiji

    2015-10-01

    A lateral cervical sinus, also known as a second pharyngeal or branchial cleft fistula/sinus, occurs when the second pharyngeal arch fails to grow caudally over the third and fourth arches, leaving remnants of the second branchial clefts in contact with the surface of the neck via a narrow canal. This type of sinus is detected on the lateral aspect of the neck directly anterior to the sternocleidomastoid muscle. We report two pediatric cases with lateral cervical sinus, and pathognomonic sonographic findings to confirm the diagnosis. The first case involved a 3-month-old boy with a sinus on the lateral neck and occasional drainage from a cervical sinus opening. Sonography revealed that the sinus tract extended between the external and internal carotid arteries. In case two, a 1-month-old girl presented with a sinus on the lateral neck and signs of acute infection at the site of a pinpoint opening. Sonography revealed an oval-shaped cystic lesion and sinus tract extending between the external and internal carotid arteries. Sonography does not require radiation or sedation for children. The best choice for the first examination for lateral cervical sinus is sonography, rather than CT, MRI, or contrast fistulograms. PMID:26576989

  5. [Failure in anterior rehabilitation of agenesic maxillary lateral incisors].

    PubMed

    Le Gall, Michel; Philippart-Rochaix, Martine; Philip-Alliez, Camille

    2016-03-01

    Agenesis of the maxillary lateral incisors poses particular problems for dentists, orthodontists and patients. Treatment of these ageneses is still highly controversial, both functionally and esthetically. The patient's smile and anterior guidance are affected and must be restored. The diagnosis is easy. Few mistakes are possible. However, managing patients with missing maxillary lateral incisors can be a challenge, commonly involving two possible treatment approaches: space opening to replace the missing lateral incisor with a prosthetic unit (denture, bridge or implant) or orthodontic space closure replacing the missing lateral incisor with the maxillary canine camouflaged to mimic the appearance of a lateral incisor. One of these two options will be adopted using multiple means...liable to trigger a multitude of possible errors. Ultimately, optimal results can only be achieved if there is excellent coordination between different practitioners in various specialties. Each clinician will have a specific role to play. Also, the patient and family are at the heart of the decision-making process, by virtue of their consent (treatment duration, financial resources) and their motivation. This multi-factorial, multi-disciplinary decision process means that treatment of the lateral incisor is an ongoing challenge for the clinician striving for the best possible result. Each case is different. No set rules exist. No single factor can be neglected if we are to avoid "failure".

  6. Effects of a continuous lateral turning device on pressure relief.

    PubMed

    Do, Nam Ho; Kim, Deog Young; Kim, Jung-Hoon; Choi, Jong Hyun; Joo, So Young; Kang, Na Kyung; Baek, Yoon Su

    2016-01-01

    [Purpose] The purpose of this study was to examine the pressure-relieving effects of a continuous lateral turning device on common pressure ulcer sites. [Subjects] Twenty-four healthy adults participated. [Methods] The design of our continuous lateral turning device was motivated by the need for an adequate pressure-relieving device for immobile and/or elderly people. The procedure of manual repositioning is embodied in our continuous lateral turning device. The interface pressure and time were measured, and comfort grade was evaluated during sessions of continuous lateral turning at 0°, 15°, 30°, and 45°. We quantified the pressure-relieving effect using peak pressure, mean pressure, and pressure time integration. [Results] Participants demonstrated pressure time integration values below the pressure-time threshold at 15°, 30°, and 45° at all the common pressure ulcer sites. Moreover, the most effective angles for pressure relief at the common pressure ulcer sites were 30° at the occiput, 15° at the left scapula, 45° at the right scapula, 45° at the sacrum, 15° at the right heel, and 30° at the left heel. However, angles greater than 30° induced discomfort. [Conclusion] Continuous lateral turning with our specially designed device effectively relieved the pressure of targeted sites. Moreover, the suggested angles of continuous lateral turning can be used to relieve pressure at targeted sites. PMID:27065531

  7. Exploring human brain lateralization with molecular genetics and genomics.

    PubMed

    Francks, Clyde

    2015-11-01

    Lateralizations of brain structure and motor behavior have been observed in humans as early as the first trimester of gestation, and are likely to arise from asymmetrical genetic-developmental programs, as in other animals. Studies of gene expression levels in postmortem tissue samples, comparing the left and right sides of the human cerebral cortex, have generally not revealed striking transcriptional differences between the hemispheres. This is likely due to lateralization of gene expression being subtle and quantitative. However, a recent re-analysis and meta-analysis of gene expression data from the adult superior temporal and auditory cortex found lateralization of transcription of genes involved in synaptic transmission and neuronal electrophysiology. Meanwhile, human subcortical mid- and hindbrain structures have not been well studied in relation to lateralization of gene activity, despite being potentially important developmental origins of asymmetry. Genetic polymorphisms with small effects on adult brain and behavioral asymmetries are beginning to be identified through studies of large datasets, but the core genetic mechanisms of lateralized human brain development remain unknown. Identifying subtly lateralized genetic networks in the brain will lead to a new understanding of how neuronal circuits on the left and right are differently fine-tuned to preferentially support particular cognitive and behavioral functions.

  8. Initiation and elongation of lateral roots in Lactuca sativa

    NASA Technical Reports Server (NTRS)

    Zhang, N.; Hasenstein, K. H.

    1999-01-01

    Lactuca sativa cv. Baijianye seedlings do not normally produce lateral roots, but removal of the root tip or application of auxin, especially indole-butyric acid, triggered the formation of lateral roots. Primordia initiated within 9 h and were fully developed after 24 h by activating the pericycle cells opposite the xylem pole. The pericycle cells divided asymmetrically into short and long cells. The short cells divided further to form primordia. The effect of root tip removal and auxin application was reversed by 6-benzylaminopurine at concentrations >10(-8) M. The cytokinin oxidase inhibitor N1-(2chloro4pyridyl)-N2-phenylurea also suppressed auxin-induced lateral rooting. The elongation of primary roots was promoted by L-alpha-(2-aminoethoxyvinyl) glycine and silver ions, but only the latter enhanced elongation of lateral roots. The data indicate that the induction of lateral roots is controlled by basipetally moving cytokinin and acropetally moving auxin. Lateral roots appear to not produce ethylene.

  9. Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis.

    PubMed

    Turner, Martin R; Swash, Michael; Ebers, George C

    2010-11-01

    The definition of the clinicopathological entity of amyotrophic lateral sclerosis evolved over half a century. Although the definitive term amyotrophic lateral sclerosis that acknowledged both upper and lower motor neuron involvement was attributed to Jean-Martin Charcot in 1874, his initial case was published nearly a decade earlier; and it is accepted that, from at least the 1830s, several others (including Charles Bell, François-Amilcar Aran and Jean Cruveilhier) had already recognized a progressive lower motor neuron-only syndrome within a broader, clinically-defined group of disorders, termed progressive muscular atrophy. Although William Gowers first grouped the three phenotypes of amyotrophic lateral sclerosis, progressive muscular atrophy and progressive bulbar palsy together as part of the same syndrome, the term motor neuron disease, as an over-arching label, was not suggested until nearly a century later by W. Russell Brain. Augustus Jacob Lockhart Clarke (1817-80) is best known for his descriptions of spinal cord anatomy. However, in two detailed case reports from the 1860s, he carried out rigorous post-mortem neuropathological studies of what appear to be classical cases of amyotrophic lateral sclerosis. Furthermore, he recognized the additional involvement of the corticospinal tracts that distinguished this from progressive muscular atrophy. Several aspects of the exquisite clinical histories documented as part of both studies, one by Charles Bland Radcliffe, resonate with contemporary debates concerning the evolution of disease in amyotrophic lateral sclerosis. These 'past masters' still have much to teach us.

  10. Lateral ventricle morphology analysis via mean latitude axis.

    PubMed

    Paniagua, Beatriz; Lyall, Amanda; Berger, Jean-Baptiste; Vachet, Clement; Hamer, Robert M; Woolson, Sandra; Lin, Weili; Gilmore, John; Styner, Martin

    2013-03-29

    Statistical shape analysis has emerged as an insightful method for evaluating brain structures in neuroimaging studies, however most shape frameworks are surface based and thus directly depend on the quality of surface alignment. In contrast, medial descriptions employ thickness information as alignment-independent shape metric. We propose a joint framework that computes local medial thickness information via a mean latitude axis from the well-known spherical harmonic (SPHARM-PDM) shape framework. In this work, we applied SPHARM derived medial representations to the morphological analysis of lateral ventricles in neonates. Mild ventriculomegaly (MVM) subjects are compared to healthy controls to highlight the potential of the methodology. Lateral ventricles were obtained from MRI scans of neonates (9-144 days of age) from 30 MVM subjects as well as age- and sex-matched normal controls (60 total). SPHARM-PDM shape analysis was extended to compute a mean latitude axis directly from the spherical parameterization. Local thickness and area was straightforwardly determined. MVM and healthy controls were compared using local MANOVA and compared with the traditional SPHARM-PDM analysis. Both surface and mean latitude axis findings differentiate successfully MVM and healthy lateral ventricle morphology. Lateral ventricles in MVM neonates show enlarged shapes in tail and head. Mean latitude axis is able to find significant differences all along the lateral ventricle shape, demonstrating that local thickness analysis provides significant insight over traditional SPHARM-PDM. This study is the first to precisely quantify 3D lateral ventricle morphology in MVM neonates using shape analysis.

  11. Effects of a continuous lateral turning device on pressure relief

    PubMed Central

    Do, Nam Ho; Kim, Deog Young; Kim, Jung-Hoon; Choi, Jong Hyun; Joo, So Young; Kang, Na Kyung; Baek, Yoon Su

    2016-01-01

    [Purpose] The purpose of this study was to examine the pressure-relieving effects of a continuous lateral turning device on common pressure ulcer sites. [Subjects] Twenty-four healthy adults participated. [Methods] The design of our continuous lateral turning device was motivated by the need for an adequate pressure-relieving device for immobile and/or elderly people. The procedure of manual repositioning is embodied in our continuous lateral turning device. The interface pressure and time were measured, and comfort grade was evaluated during sessions of continuous lateral turning at 0°, 15°, 30°, and 45°. We quantified the pressure-relieving effect using peak pressure, mean pressure, and pressure time integration. [Results] Participants demonstrated pressure time integration values below the pressure-time threshold at 15°, 30°, and 45° at all the common pressure ulcer sites. Moreover, the most effective angles for pressure relief at the common pressure ulcer sites were 30° at the occiput, 15° at the left scapula, 45° at the right scapula, 45° at the sacrum, 15° at the right heel, and 30° at the left heel. However, angles greater than 30° induced discomfort. [Conclusion] Continuous lateral turning with our specially designed device effectively relieved the pressure of targeted sites. Moreover, the suggested angles of continuous lateral turning can be used to relieve pressure at targeted sites. PMID:27065531

  12. Lateralization for dynamic facial expressions in human superior temporal sulcus.

    PubMed

    De Winter, François-Laurent; Zhu, Qi; Van den Stock, Jan; Nelissen, Koen; Peeters, Ronald; de Gelder, Beatrice; Vanduffel, Wim; Vandenbulcke, Mathieu

    2015-02-01

    Most face processing studies in humans show stronger activation in the right compared to the left hemisphere. Evidence is largely based on studies with static stimuli focusing on the fusiform face area (FFA). Hence, the pattern of lateralization for dynamic faces is less clear. Furthermore, it is unclear whether this property is common to human and non-human primates due to predisposing processing strategies in the right hemisphere or that alternatively left sided specialization for language in humans could be the driving force behind this phenomenon. We aimed to address both issues by studying lateralization for dynamic facial expressions in monkeys and humans. Therefore, we conducted an event-related fMRI experiment in three macaques and twenty right handed humans. We presented human and monkey dynamic facial expressions (chewing and fear) as well as scrambled versions to both species. We studied lateralization in independently defined face-responsive and face-selective regions by calculating a weighted lateralization index (LIwm) using a bootstrapping method. In order to examine if lateralization in humans is related to language, we performed a separate fMRI experiment in ten human volunteers including a 'speech' expression (one syllable non-word) and its scrambled version. Both within face-responsive and selective regions, we found consistent lateralization for dynamic faces (chewing and fear) versus scrambled versions in the right human posterior superior temporal sulcus (pSTS), but not in FFA nor in ventral temporal cortex. Conversely, in monkeys no consistent pattern of lateralization for dynamic facial expressions was observed. Finally, LIwms based on the contrast between different types of dynamic facial expressions (relative to scrambled versions) revealed left-sided lateralization in human pSTS for speech-related expressions compared to chewing and emotional expressions. To conclude, we found consistent laterality effects in human posterior STS but not

  13. Do Age and Weight Bearing Films Affect Lateral Joint Space and Fibular Height Measurements in Patients with Discoid Lateral Meniscus?

    PubMed Central

    Milewski, Matthew David; Krochak, Ryan; Duarte, Andrew J.; Marchese, Joseph; Pace, James Lee; Broom, Alexander M.; Solomito, Matthew

    2016-01-01

    Objectives: Several radiographic parameters have been associated with discoid lateral meniscus. We sought to determine the effect of age and weight bearing (WB) on radiographic parameters associated with lateral discoid menisci in pediatric patients. Methods: Radiographs of patients with arthroscopically confirmed lateral discoid meniscus were compared to age, side, sex matched individuals with confirmed normal menisci. The radiographs were measured by a pediatric orthopaedic sports medicine attending and two orthopaedic residents for the following parameters: lateral joint space width (LJSW), fibular head height (FHH), width of the distal femur (WDF), tibial spine height (TSH), cupping of the lateral tibial plateau (CLTP), and obliquity of the lateral tibial plateau (OLTP). The results of this review focus on FHH and LJSW only. Results: 68 knees with discoid lateral menisci with a mean age of 11.6 ± 3.3 (15 WB films) were compared to 67 control knees with a mean age of 11.9 ± 3.2 (15 WB films). Results indicated that there were significant differences between the discoid and control groups when comparing LJSW (8.7 ± 2.2 mm discoid compared to 7.6 ± 2.1 mm control p=0.002) and FHH (13.5 ± 4.5 mm discoid compared to 18.6 ± 3.9 mm control p<0.001). Inter-rater reliability was satisfactory for LJSW and FHH (ICC 0.635 and 0.759 respectively). WB films were noted to have better inter-rater reliability compared to NWB films for LJSW (ICC 0.729 vs 0.514 respectively) but reduced inter-rater reliability for FHH (ICC 0.625 vs 0.868 respectively). Subgroup analysis based on age was also done comparing patients under 10 years old, patients between 10-14 years old, and patients over 14 years old. The FHH measurement was significantly decreased (indicative of a high fibular head) in the discoid group in all age groups. However, LJSW was only noted to be significantly different in patients over the age of 14. Conclusion: Increased lateral joint space width and a high

  14. Hemispheric lateralization of verbal and spatial working memory during adolescence.

    PubMed

    Nagel, Bonnie J; Herting, Megan M; Maxwell, Emily C; Bruno, Richard; Fair, Damien

    2013-06-01

    Adult functional magnetic resonance imaging (fMRI) literature suggests that a left-right hemispheric dissociation may exist between verbal and spatial working memory (WM), respectively. However, investigation of this type has been obscured by incomparable verbal and spatial WM tasks and/or visual inspection at arbitrary thresholds as means to assess lateralization. Furthermore, it is unclear whether this hemispheric lateralization is present during adolescence, a time in which WM skills are improving, and whether there is a developmental association with laterality of brain functioning. This study used comparable verbal and spatial WM n-back tasks during fMRI and a bootstrap analysis approach to calculate lateralization indices (LIs) across several thresholds to examine the potential of a left-right WM hemispheric dissociation in healthy adolescents. We found significant left hemispheric lateralization for verbal WM, most notably in the frontal and parietal lobes, as well as right hemisphere lateralization for spatial WM, seen in frontal and temporal cortices. Although no significant relationships were observed between LI and age or LI and performance, significant age-related patterns of brain activity were demonstrated during both verbal and spatial WM. Specifically, increased adolescent age was associated with less activity in the default mode brain network during verbal WM. In contrast, increased adolescent age was associated with greater activity in task-positive posterior parietal cortex during spatial working memory. Our findings highlight the importance of utilizing non-biased statistical methods and comparable tasks for determining patterns of functional lateralization. Our findings also suggest that, while a left-right hemispheric dissociation of verbal and spatial WM is apparent by early adolescence, age-related changes in functional activation during WM are also present.

  15. The Contribution of the Corpus Callosum to Language Lateralization

    PubMed Central

    Hinkley, Leighton B.N.; Marco, Elysa J.; Brown, Ethan G.; Bukshpun, Polina; Gold, Jacquelyn; Hill, Susanna; Findlay, Anne M.; Jeremy, Rita J.; Wakahiro, Mari L.; Barkovich, A. James; Mukherjee, Pratik

    2016-01-01

    The development of hemispheric lateralization for language is poorly understood. In one hypothesis, early asymmetric gene expression assigns language to the left hemisphere. In an alternate view, language is represented a priori in both hemispheres and lateralization emerges via cross-hemispheric communication through the corpus callosum. To address this second hypothesis, we capitalized on the high temporal and spatial resolution of magnetoencephalographic imaging to measure cortical activity during language processing, speech preparation, and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched neurotypical individuals. In contrast to strongly lateralized left hemisphere activations for language in neurotypical controls, participants with complete or partial AgCC exhibited bilateral hemispheric activations in both auditory or visually driven language tasks, with complete AgCC participants showing significantly more right hemisphere activations than controls or than individuals with partial AgCC. In AgCC individuals, language laterality positively correlated with verbal IQ. These findings suggest that the corpus callosum helps to drive language lateralization. SIGNIFICANCE STATEMENT The role that corpus callosum development has on the hemispheric specialization of language is poorly understood. Here, we used magnetoencephalographic imaging during linguistic tests (verb generation, picture naming) to test for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced laterality (i.e., greater likelihood of bilaterality or right hemisphere dominance) in this cohort compared with controls, especially in patients with complete agenesis. Laterality was positively correlated with behavioral measures of verbal intelligence. These findings provide support for the hypothesis that the callosum aids in functional specialization throughout neural development and that the loss of this mechanism

  16. Fold patterns, lateral ramps and seismicity in central Pennsylvania

    USGS Publications Warehouse

    Pohn, H.A.; Coleman, J.L.

    1991-01-01

    The Susquehanna lateral ramp crosses the entire length of Pennsylvania in a NNE direction and extends into southern New York State. Its presence was first suspected because of a dramatic change in fold wavelength across the Susquehanna River, seen on both side-looking airborne radar (SLAR *) data and the geologic map of Pennsylvania. Seismic reflection profiles confirm the presence of a ramp and show the detailed nature of structures associated with it. These structures include antiformal stacks, juxtaposed anticlines and synclines, and folds beheaded by thrust faults. The change in the fold pattern, which led to recognizing the lateral ramp, occurs above a rapid dropoff in depth to the basement suggesting that the ramp and the basement configuration may somehow be related. In plan view, eleven earthquakes are spatially related to the Susquehanna lateral ramp, although they are in the basement rocks rather than in the cover rocks which contain the lateral ramp itself. The earthquakes are, therefore, not likely directly associated with the ramp, though they may be affiliated with strike-slip faulting in the basement which, itself, appears to be partly responsible for the formation of the ramp. The initial age of the faulting along, and in the vicinity of, the Susquehanna lateral ramp is presumably Early to Middle Paleozoic. However, the presence of a surficially-exposed Mesozoic dike along the ramp and modern seismicity suggest that the Susquehanna lateral ramp may be a zone of protracted, and perhaps repeated, tectonism which is currently being reactivated. A preliminary evaluation of the distribution of modern earthquakes in the Valley and Ridge, Blue Ridge and Appalachian Plateau shows that nearly half of the earthquakes are located under lateral ramps. If this observation is true, the presence of ramps may be a useful geological indicator of areas susceptible to seismicity. ?? 1991.

  17. Hemispheric lateralization of verbal and spatial working memory during adolescence

    PubMed Central

    Nagel, Bonnie J.; Herting, Megan M.; Maxwell, Emily C.; Bruno, Richard; Fair, Damien

    2013-01-01

    Adult functional magnetic resonance imaging (fMRI) literature suggests that a left-right hemispheric dissociation may exist between verbal and spatial working memory (WM), respectively. However, investigation of this type has been obscured by incomparable verbal and spatial WM tasks and/or visual inspection at arbitrary thresholds as means to assess lateralization. Furthermore, it is unclear whether this hemispheric lateralization is present during adolescence, a time in which WM skills are improving, and whether there is a developmental association with laterality of brain functioning. This study used comparable verbal and spatial WM n-back tasks during fMRI and a bootstrap analysis approach to calculate lateralization indices (LI) across several thresholds to examine the potential of a left-right WM hemispheric dissociation in healthy adolescents. We found significant left hemispheric lateralization for verbal WM, most notably in the frontal and parietal lobes, as well as right hemisphere lateralization for spatial WM, seen in frontal and temporal cortices. Although no significant relationships were observed between LI and age or LI and performance, significant age-related patterns of brain activity were demonstrated during both verbal and spatial WM. Specifically, increased adolescent age was associated with less activity in the default mode brain network during verbal WM. In contrast, increased adolescent age was associated with greater activity in task-positive posterior parietal cortex during spatial working memory. Our findings highlight the importance of utilizing non-biased statistical methods and comparable tasks for determining patterns of functional lateralization. Our findings also suggest that, while a left-right hemispheric dissociation of verbal and spatial WM is apparent by early adolescence, age-related changes in functional activation during WM are also present. PMID:23511846

  18. River Elongation as a Proxy for Lateral Channel Activity

    NASA Astrophysics Data System (ADS)

    Lauer, J. W.

    2009-12-01

    Lateral channel movement is a process that is tightly linked to both channel hydraulics and sediment transport, strongly influences floodplain ecology, and also has great relevance for banktop property owners. The correlation between channel migration rate and channel curvature usually causes meandering river channels to elongate as they migrate laterally. Over the long term, the increase in sinuosity is compensated by a rapid decrease in sinuosity where and when river bends shorten through cutoff processes. However, the elongation for most meander bends in systems free to migrate across wide floodplains often occurs relatively uniformly throughout the system. Consequently, the rate of elongation of individual river bends, integrated across a river reach, offers a simple mechanism for characterizing the reach’s lateral activity. Spatial series of accumulated elongation can also be used to delineate reaches with similar properties. We use aerial imagery pairs to compare rates of lateral channel centerline shifting with channel centerline elongation for reaches many bends long along eight different rivers with widths ranging from 12 to 584 m. Except where bends translate downstream without changing form, elongation rates are closely linked to lateral shifting. In several cases, a change in elongation rate corresponds closely with a change in channel width, discharge, and/or bed material. For reaches free to migrate across a wide, unconfined floodplain and where lateral migration measurements are likely of high quality, the average ratio between the reach average migration rate normalized by channel width and the rate of sinuosity increase (excluding bends that experienced a cutoff between imagery dates) is approximately 5.6. Since elongation rate measurements can be made accurately even from photos that are poorly aligned, the relationship between sinuosity increase and lateral migration potentially provides a means of bypassing time-consuming georeferencing

  19. Improved accuracy in Risser sign grading with lateral spinal radiography

    PubMed Central

    2008-01-01

    Development of the ossification of the iliac crest is used to assess the remaining spinal growth. The clinical value of the Risser sign has been questioned because of its inaccuracy in grades 3 and 4. Estimation of the Risser sign based on the lateral spinal radiograph has not been reported. The aim of the study was to evaluate the course of ossification of the iliac apophysis along its full extension and to investigate relevance of the lateral spinal radiograph for more accurate Risser sign grading. Cross sectional analysis of spinal frontal and lateral long cassette standing spinal radiographs of 201 girls aged from 10.2 to 20.0 years were done. On the lateral spinal view, the ossification of the posterior part of the iliac apophysis was quantified at four grades: absent (A), partial (B), complete (C) or fused (D). The position of the posterior superior iliac spine was studied on both views as well as in pelvic specimens. The results showed that the posterior one-third portion of the iliac apophysis was sagittally oriented and obscured on the frontal radiograph by the sacroiliac junction. It could be studied on the lateral radiograph and revealed a different grading of the apophysis excursion in 58 of 201 (29%) patients, comparing to the frontal view. Both advanced or delayed ossification was observed and assessed with Lateral Risser Modifiers. Twenty-five percent of the patients at Risser 0 or 1 or 2 demonstrated a simultaneous ossification of the most anterior and the most posterior part of the iliac crest. The Risser grades of capping or fusion could be more precisely diagnosed using lateral radiograph in complement to the frontal one. The conclusions drawn from this study were: (1) Currently used Risser sign grading does not consider the actual excursion of the iliac apophysis, because one-third of the apophysis cannot be observed on the frontal radiograph. (2) Iliac apophysis full excursion or fusion can be more accurately estimated when the lateral spinal

  20. Improved accuracy in Risser sign grading with lateral spinal radiography.

    PubMed

    Kotwicki, Tomasz

    2008-12-01

    Development of the ossification of the iliac crest is used to assess the remaining spinal growth. The clinical value of the Risser sign has been questioned because of its inaccuracy in grades 3 and 4. Estimation of the Risser sign based on the lateral spinal radiograph has not been reported. The aim of the study was to evaluate the course of ossification of the iliac apophysis along its full extension and to investigate relevance of the lateral spinal radiograph for more accurate Risser sign grading. Cross sectional analysis of spinal frontal and lateral long cassette standing spinal radiographs of 201 girls aged from 10.2 to 20.0 years were done. On the lateral spinal view, the ossification of the posterior part of the iliac apophysis was quantified at four grades: absent (A), partial (B), complete (C) or fused (D). The position of the posterior superior iliac spine was studied on both views as well as in pelvic specimens. The results showed that the posterior one-third portion of the iliac apophysis was sagittally oriented and obscured on the frontal radiograph by the sacroiliac junction. It could be studied on the lateral radiograph and revealed a different grading of the apophysis excursion in 58 of 201 (29%) patients, comparing to the frontal view. Both advanced or delayed ossification was observed and assessed with Lateral Risser Modifiers. Twenty-five percent of the patients at Risser 0 or 1 or 2 demonstrated a simultaneous ossification of the most anterior and the most posterior part of the iliac crest. The Risser grades of capping or fusion could be more precisely diagnosed using lateral radiograph in complement to the frontal one. The conclusions drawn from this study were: (1) Currently used Risser sign grading does not consider the actual excursion of the iliac apophysis, because one-third of the apophysis cannot be observed on the frontal radiograph. (2) Iliac apophysis full excursion or fusion can be more accurately estimated when the lateral spinal

  1. Experiment and Simulation of the Lateral Gauge in Glass Targets

    NASA Astrophysics Data System (ADS)

    Church, P. D.; Grief, A.; Tsembelis, K.; Proud, W. G.; Murray, N. H.

    2004-07-01

    The lateral stress in materials has been measured, under shock wave loading, using manganin gauges mounted normal to the direction of shock propagation. Generally the sample has been sectioned along the direction of impact and adhered again with the gauge in this plane. A series of previous papers have reported a two-step structure in the lateral gauge history, the presence or absence of which indicates the presence of failure fronts in a variety of materials, such as ceramics and glasses. In glasses the evidence also includes velocity interferometry (VISAR) traces and high-speed photography where the failure front is also seen. The gauge configurations have been simulated using the QinetiQ Eulerian hydrocode GRIM3D to identify the effect of local material response on the function of the lateral gauge. These initial results have illustrated that tensile fractures occur along the material at the gauge/sample interface, which propagate behind the main shock front. Another feature is that the flyer plate can jet into the region of the lateral cut and therefore impart a separate shock into this region. Curiously these effects seem to have little impact on the predicted lateral stress history.

  2. Lateral orbitofrontal cortex links social impressions to political choices.

    PubMed

    Xia, Chenjie; Stolle, Dietlind; Gidengil, Elisabeth; Fellows, Lesley K

    2015-06-01

    Recent studies of political behavior suggest that voting decisions can be influenced substantially by "first-impression" social attributions based on physical appearance. Separate lines of research have implicated the orbitofrontal cortex (OFC) in the judgment of social traits on the one hand and economic decision-making on the other, making this region a plausible candidate for linking social attributions to voting decisions. Here, we asked whether OFC lesions in humans disrupted the ability to judge traits of political candidates or affected how these judgments influenced voting decisions. Seven patients with lateral OFC damage, 18 patients with frontal damage sparing the lateral OFC, and 53 matched healthy participants took part in a simulated election paradigm, in which they voted for real-life (but unknown) candidates based only on photographs of their faces. Consistent with previous work, attributions of "competence" and "attractiveness" based on candidate appearance predicted voting behavior in the healthy control group. Frontal damage did not affect substantially the ability to make competence or attractiveness judgments, but patients with damage to the lateral OFC differed from other groups in how they applied this information when voting. Only attractiveness ratings had any predictive power for voting choices after lateral OFC damage, whereas other frontal patients and healthy controls relied on information about both competence and attractiveness in making their choice. An intact lateral OFC may not be necessary for judgment of social traits based on physical appearance, but it seems to be crucial in applying this information in political decision-making. PMID:26041918

  3. Plane development of lateral surfaces for inspection systems

    NASA Astrophysics Data System (ADS)

    Francini, F.; Fontani, D.; Jafrancesco, D.; Mercatelli, L.; Sansoni, P.

    2006-08-01

    The problem of developing the lateral surfaces of a 3D object can arise in item inspection using automated imaging systems. In an industrial environment, these control systems typically work at high rate and they have to assure a reliable inspection of the single item. For compactness requirements it is not convenient to utilise three or four CCD cameras to control all the lateral surfaces of an object. Moreover it is impossible to mount optical components near the object if it is placed on a conveyor belt. The paper presents a system that integrates on a single CCD picture the images of both the frontal surface and the lateral surface of an object. It consists of a freeform lens mounted in front of a CCD camera with a commercial lens. The aim is to have a good magnification of the lateral surface, maintaining a low aberration level for exploiting the pictures in an image processing software. The freeform lens, made in plastics, redirects the light coming from the object to the camera lens. The final result is to obtain on the CCD: - the frontal and lateral surface images, with a selected magnification (even with two different values for the two images); - a gap between these two images, so an automatic method to analyse the images can be easily applied. A simple method to design the freeform lens is illustrated. The procedure also allows to obtain the imaging system modifying a current inspection system reducing the cost.

  4. Deep Transverse Lateral Retinaculum Reconstruction for Medial Patellar Instability.

    PubMed

    Sanchis-Alfonso, Vicente; Montesinos-Berry, Erik; Monllau, Joan Carles; Andrish, Jack

    2015-06-01

    Medial patellar instability can be a disabling complication of an extensive lateral retinaculum release. It is often overlooked, and for the diagnosis, it is necessary to have a high index of suspicion. Typically, the patient feels a new pain and new instability after the lateral retinaculum release that are distinct from, and much worse than, those before surgery. All of our patients had significant relief from their pain with "reverse" McConnell taping. If there is a significant improvement in symptoms after this taping and stress radiographs or stress axial computed tomography scans show an objective pathologic medial patellar displacement, reconstruction of the lateral retinaculum should be considered. This article details our technique for reconstruction of the deep transverse layer of the lateral retinaculum using an anterior strip of the iliotibial band. This strip is detached from its insertion onto the Gerdy tubercle and then reflected proximally beyond the level of the lateral femoral epicondyle. Finally, it is attached either by direct suture to the remaining prepatellar and peripatellar retinaculum if there is adequate tissue present or by a suture anchor. PMID:26258038

  5. Analysis of quantitative trait loci for behavioral laterality in mice.

    PubMed Central

    Roubertoux, Pierre L; Le Roy, Isabelle; Tordjman, Sylvie; Cherfou, Améziane; Migliore-Samour, Danièle

    2003-01-01

    Laterality is believed to have genetic components, as has been deduced from family studies in humans and responses to artificial selection in mice, but these genetic components are unknown and the underlying physiological mechanisms are still a subject of dispute. We measured direction of laterality (preferential use of left or right paws) and degree of laterality (absolute difference between the use of left and right paws) in C57BL/6ByJ (B) and NZB/BlNJ (N) mice and in their F(1) and F(2) intercrosses. Measurements were taken of both forepaws and hind paws. Quantitative trait loci (QTL) did not emerge for direction but did for degree of laterality. One QTL for forepaw (LOD score = 5.6) and the second QTL for hind paw (LOD score = 7.2) were both located on chromosome 4 and their peaks were within the same confidence interval. A QTL for plasma luteinizing hormone concentration was also found in the confidence interval of these two QTL. These results suggest that the physiological mechanisms underlying degree of laterality react to gonadal steroids. PMID:12663540

  6. Preschoolers' Psychopathology and Temperament Predict Mothers' Later Mood Disorders.

    PubMed

    Allmann, Anna E S; Kopala-Sibley, Daniel C; Klein, Daniel N

    2016-04-01

    Considerable research exists documenting the relationship between maternal mood disorders, primarily major depressive disorder (MDD), and a variety of negative child outcomes. By contrast, research exploring the reverse pathway whereby child traits are associated with later maternal mood disorders is much more limited. We examined whether young children's temperament and psychopathology predicted maternal mood disorders approximately 6 years later. Child temperament and symptoms were assessed at age three using semi-structured diagnostic interviews and parent-report inventories. Maternal psychopathology was assessed with semi-structured interviews when children were 3 and 9 years old. Mothers also reported on their marital satisfaction when children were 3 and 6 years old. Child temperamental negative affectivity (NA), depressive symptoms, and externalizing behavior problems significantly predicted maternal mood disorders over and above prior maternal mood, anxiety, and substance disorders. The link between children's early externalizing symptoms and maternal mood disorders 6 years later was mediated by maternal marital satisfaction 3 years after the initial assessment. These findings suggest that early child temperament and psychopathology contribute to risk for later maternal mood disorders both directly and through their impact on the marital system. Research indicates that effective treatment of maternal depression is associated with positive outcomes for children; however, this study suggests that treating early child problems may mitigate the risk of later maternal psychopathology. PMID:26219263

  7. Effects of Football Collars on Cervical Hyperextension and Lateral Flexion

    PubMed Central

    Gorden, Jeffery A.; Swanik, C. Buz; Swanik, Kathleen A.

    2003-01-01

    Objectives: To evaluate the effectiveness of 3 football collars in reducing cervical range of motion. Design and Setting: A repeated-measures design in a controlled laboratory setting. Subjects: Fifteen male National Collegiate Athletic Association Division I varsity football athletes. Measurements: Cervical hyperextension and lateral flexion were measured with video analysis. Subjects underwent 5 testing conditions: standard football helmet, standard helmet and shoulder pads, and standard pads with the addition of the Cowboy Collar, A-Force Neck Collar, or a foam neck roll. Subjects performed motions both actively and passively. Results: All 3 collars reduced hyperextension when compared with the helmet and shoulder pads alone (P < .05); in addition, the Cowboy Collar was superior to the foam neck roll (P < .05) in reducing hyperextension. No collar reduced passive lateral flexion when compared with the helmet and shoulder pads, but the foam neck roll permitted significantly less active lateral flexion (P < .01) than the other 3 brace conditions. Conclusions: In a laboratory setting, cervical hyperextension can be controlled through the use of various cervical collars. Cervical lateral flexion (a more common cause of burners in a scholastic population) cannot be controlled with any of the cervical collars tested. Moreover, foam collars may impede active lateral flexion while not providing additional protection when loaded. These results are limited in that they were produced in a controlled situation as opposed to active football play. PMID:14608429

  8. LATERAL DOWNFLOWS IN SUNSPOT PENUMBRAL FILAMENTS AND THEIR TEMPORAL EVOLUTION

    SciTech Connect

    Esteban Pozuelo, S.; Rubio, L. R. Bellot; Rodríguez, J. de la Cruz

    2015-04-20

    We study the temporal evolution of downflows observed at the lateral edges of penumbral filaments in a sunspot located very close to the disk center. Our analysis is based on a sequence of nearly diffraction-limited scans of the Fe i 617.3 nm line taken with the CRisp Imaging Spectro-Polarimeter instrument at the Swedish 1 m Solar Telescope. We compute Dopplergrams from the observed intensity profiles using line bisectors and filter the resulting velocity maps for subsonic oscillations. Lateral downflows appear everywhere in the center-side penumbra as small, weak patches of redshifts next to or along the edges of blueshifted flow channels. These patches have an intermittent life and undergo mergings and fragmentations quite frequently. The lateral downflows move together with the hosting filaments and react to their shape variations, very much resembling the evolution of granular convection in the quiet Sun. There is a good relation between brightness and velocity in the center-side penumbra, with downflows being darker than upflows on average, which is again reminiscent of quiet Sun convection. These results point to the existence of overturning convection in sunspot penumbrae, with elongated cells forming filaments where the flow is upward but very inclined, and weak lateral downward flows. In general, the circular polarization profiles emerging from the lateral downflows do not show sign reversals, although sometimes we detect three-lobed profiles that are suggestive of opposite magnetic polarities in the pixel.

  9. Lateral Downflows in Sunspot Penumbral Filaments and their Temporal Evolution

    NASA Astrophysics Data System (ADS)

    Esteban Pozuelo, S.; Bellot Rubio, L. R.; de la Cruz Rodríguez, J.

    2015-04-01

    We study the temporal evolution of downflows observed at the lateral edges of penumbral filaments in a sunspot located very close to the disk center. Our analysis is based on a sequence of nearly diffraction-limited scans of the Fe i 617.3 nm line taken with the CRisp Imaging Spectro-Polarimeter instrument at the Swedish 1 m Solar Telescope. We compute Dopplergrams from the observed intensity profiles using line bisectors and filter the resulting velocity maps for subsonic oscillations. Lateral downflows appear everywhere in the center-side penumbra as small, weak patches of redshifts next to or along the edges of blueshifted flow channels. These patches have an intermittent life and undergo mergings and fragmentations quite frequently. The lateral downflows move together with the hosting filaments and react to their shape variations, very much resembling the evolution of granular convection in the quiet Sun. There is a good relation between brightness and velocity in the center-side penumbra, with downflows being darker than upflows on average, which is again reminiscent of quiet Sun convection. These results point to the existence of overturning convection in sunspot penumbrae, with elongated cells forming filaments where the flow is upward but very inclined, and weak lateral downward flows. In general, the circular polarization profiles emerging from the lateral downflows do not show sign reversals, although sometimes we detect three-lobed profiles that are suggestive of opposite magnetic polarities in the pixel.

  10. Lateral position detection and control for friction stir systems

    DOEpatents

    Fleming, Paul; Lammlein, David; Cook, George E.; Wilkes, Don Mitchell; Strauss, Alvin M.; Delapp, David; Hartman, Daniel A.

    2010-12-14

    A friction stir system for processing at least a first workpiece includes a spindle actuator coupled to a rotary tool comprising a rotating member for contacting and processing the first workpiece. A detection system is provided for obtaining information related to a lateral alignment of the rotating member. The detection system comprises at least one sensor for measuring a force experienced by the rotary tool or a parameter related to the force experienced by the rotary tool during processing, wherein the sensor provides sensor signals. A signal processing system is coupled to receive and analyze the sensor signals and determine a lateral alignment of the rotating member relative to a selected lateral position, a selected path, or a direction to decrease a lateral distance relative to the selected lateral position or selected path. In one embodiment, the friction stir system can be embodied as a closed loop tracking system, such as a robot-based tracked friction stir welding (FSW) or friction stir processing (FSP) system.

  11. Ring-shaped lateral meniscus with hypoplasic anterior cruciate ligament.

    PubMed

    Esteves, Cátia; Castro, Ricardo; Cadilha, Rui; Raposo, Frederico; Melão, Lina

    2015-12-01

    Knee joint lesions can be solitary or occur concomitantly with other lower limb abnormalities. Ring-shaped lateral meniscus (RSM) and hypoplasic anterior cruciate ligament (ACL) are two rare malformations. The therapeutic management of such abnormalities is not consensual, and highly depends on clinical symptomatology. We report a case of a 25-year-old girl with progressive knee pain whose MRI demonstrated a continuous segment of lateral meniscus situated along the medial aspect of the lateral compartment, continuous with the otherwise normal-appearing lateral meniscus, compatible with an RSM. This anatomic variant can be mistaken by a displaced meniscal fragment, like a bucket-handle tear, a central tear of a discoid meniscus, or incomplete discoid meniscus, as previously reported. Her MRI examination also showed a thinned ACL with anomalous lateral course. This abnormality may be mistaken for an ACL rupture and/or a meniscofemoral ligament with agenesis of ACL. Multiple images in different planes as well as following the course of meniscal and ligaments are critical clues to avoid misdiagnosis. As a result, the diagnosis of an RSM along with hypoplasic ACL with abnormal attachment was assumed based on MRI and confirmed during arthroscopy. The patient was treated conservatively with clinical outcome improvement.

  12. Post-seismic relaxation theory on laterally heterogeneous viscoelastic model

    USGS Publications Warehouse

    Pollitz, F.F.

    2003-01-01

    Investigation was carried out into the problem of relaxation of a laterally heterogeneous viscoelastic Earth following an impulsive moment release event. The formal solution utilizes a semi-analytic solution for post-seismic deformation on a laterally homogeneous Earth constructed from viscoelastic normal modes, followed by application of mode coupling theory to derive the response on the aspherical Earth. The solution is constructed in the Laplace transform domain using the correspondence principle and is valid for any linear constitutive relationship between stress and strain. The specific implementation described in this paper is a semi-analytic discretization method which assumes isotropic elastic structure and a Maxwell constitutive relation. It accounts for viscoelastic-gravitational coupling under lateral variations in elastic parameters and viscosity. For a given viscoelastic structure and minimum wavelength scale, the computational effort involved with the numerical algorithm is proportional to the volume of the laterally heterogeneous region. Examples are presented of the calculation of post-seismic relaxation with a shallow, laterally heterogeneous volume following synthetic impulsive seismic events, and they illustrate the potentially large effect of regional 3-D heterogeneities on regional deformation patterns.

  13. A lateral signalling pathway coordinates shape volatility during cell migration

    PubMed Central

    Zhang, Liang; Luga, Valbona; Armitage, Sarah K.; Musiol, Martin; Won, Amy; Yip, Christopher M.; Plotnikov, Sergey V.; Wrana, Jeffrey L.

    2016-01-01

    Cell migration is fundamental for both physiological and pathological processes. Migrating cells usually display high dynamics in morphology, which is orchestrated by an integrative array of signalling pathways. Here we identify a novel pathway, we term lateral signalling, comprised of the planar cell polarity (PCP) protein Pk1 and the RhoGAPs, Arhgap21/23. We show that the Pk1–Arhgap21/23 complex inhibits RhoA, is localized on the non-protrusive lateral membrane cortex and its disruption leads to the disorganization of the actomyosin network and altered focal adhesion dynamics. Pk1-mediated lateral signalling confines protrusive activity and is regulated by Smurf2, an E3 ubiquitin ligase in the PCP pathway. Furthermore, we demonstrate that dynamic interplay between lateral and protrusive signalling generates cyclical fluctuations in cell shape that we quantify here as shape volatility, which strongly correlates with migration speed. These studies uncover a previously unrecognized lateral signalling pathway that coordinates shape volatility during productive cell migration. PMID:27226243

  14. Lateral line placodes are induced during neurulation in the axolotl.

    PubMed

    Schlosser, G; Northcutt, R G

    2001-06-01

    In order to determine the time window for induction of lateral line placodes in the axolotl, we performed two series of heterotopic and isochronic transplantations from pigmented to albino embryos at different stages of embryogenesis and assessed the distribution of pigmented neuromasts in the hosts at later stages. First, ectoderm from the prospective placodal region was transplanted to the belly between early neurula and mid tailbud stages (stages 13-27). Whereas grafts from early neurulae typically differentiated only into epidermis, grafts from late neural fold stages on reliably resulted in differentiation of ectopic pigmented neuromasts. Second, belly ectoderm was transplanted to the prospective placodal region between early neurula and tailbud stages (stages 13-35). Normal lateral lines containing pigmented neuromasts formed in most embryos when grafts were performed prior to early tailbud stages (stage 24) but not when they were performed later. Our findings indicate that lateral line placodes, from which neuromasts originate, are already determined at late neural fold stages (first series of grafts) but are inducible until early tailbud stages (second series of grafts). A further series of heterochronic transplantations demonstrated that the decline of inducibility at mid tailbud stages is mainly due to the loss of ectodermal competence. PMID:11356019

  15. Lateral orbitofrontal cortex links social impressions to political choices.

    PubMed

    Xia, Chenjie; Stolle, Dietlind; Gidengil, Elisabeth; Fellows, Lesley K

    2015-06-01

    Recent studies of political behavior suggest that voting decisions can be influenced substantially by "first-impression" social attributions based on physical appearance. Separate lines of research have implicated the orbitofrontal cortex (OFC) in the judgment of social traits on the one hand and economic decision-making on the other, making this region a plausible candidate for linking social attributions to voting decisions. Here, we asked whether OFC lesions in humans disrupted the ability to judge traits of political candidates or affected how these judgments influenced voting decisions. Seven patients with lateral OFC damage, 18 patients with frontal damage sparing the lateral OFC, and 53 matched healthy participants took part in a simulated election paradigm, in which they voted for real-life (but unknown) candidates based only on photographs of their faces. Consistent with previous work, attributions of "competence" and "attractiveness" based on candidate appearance predicted voting behavior in the healthy control group. Frontal damage did not affect substantially the ability to make competence or attractiveness judgments, but patients with damage to the lateral OFC differed from other groups in how they applied this information when voting. Only attractiveness ratings had any predictive power for voting choices after lateral OFC damage, whereas other frontal patients and healthy controls relied on information about both competence and attractiveness in making their choice. An intact lateral OFC may not be necessary for judgment of social traits based on physical appearance, but it seems to be crucial in applying this information in political decision-making.

  16. Incidence of lateral meniscus injury in professional basketball players.

    PubMed

    Krinsky, M B; Abdenour, T E; Starkey, C; Albo, R A; Chu, D A

    1992-01-01

    We reviewed National Basketball Trainers Association data over a 6-year period to determine the incidence of lateral meniscus injury among professional basketball players. Our results indicated that 58% of all injuries involved the lateral meniscus, while 42% involved the medial meniscus. This differs from what other authors have reported for basketball players. The lateral meniscus may be vulnerable to chronic injury and subject to microtrauma from repetitive submaximal stresses associated with cutting or changing direction while running, or from pivoting. A professional player is at more risk of injury during a game than practice, and thus is exposed to injury more than a collegian because the professional season has three to four times as many games. Also, magnetic resonance imaging may aid the physician in accurately diagnosing some tears that would otherwise have gone undetected or required arthroscopy for diagnosis. In addition, injury to the lateral meniscus could produce secondary symptoms such as instability or patellofemoral pain to structures other than the lateral meniscus.

  17. Vehicle lateral state estimation based on measured tyre forces.

    PubMed

    Tuononen, Ari J

    2009-01-01

    Future active safety systems need more accurate information about the state of vehicles. This article proposes a method to evaluate the lateral state of a vehicle based on measured tyre forces. The tyre forces of two tyres are estimated from optically measured tyre carcass deflections and transmitted wirelessly to the vehicle body. The two remaining tyres are so-called virtual tyre sensors, the forces of which are calculated from the real tyre sensor estimates. The Kalman filter estimator for lateral vehicle state based on measured tyre forces is presented, together with a simple method to define adaptive measurement error covariance depending on the driving condition of the vehicle. The estimated yaw rate and lateral velocity are compared with the validation sensor measurements. PMID:22291535

  18. On Coupled Longitudinal and Lateral Vibrations of Elastic Rods

    NASA Astrophysics Data System (ADS)

    O'REILLY, O. M.

    2001-11-01

    In this paper, the coupled longitudinal and lateral vibrations of a rectangular parallelepiped composed of a uniform, isotropic, elastic body are examined. The one-dimensional model for the body was developed by Green, Naghdi and several of their co-workers. It is based on a Cosserat or directed rod theory. The frequency spectrum is found to divide naturally into three regions which are separated by degenerate cases. When the cross-section of the body is square, a natural splitting of the modes occurs. One-half of this split involves motions coupling the axial extension and symmetric lateral deformation of the body. The other half involves asymmetric lateral deformations. The cases of a free-free rod and a cantilevered rod are discussed and the results compared to existing works in the literature which use the three-dimensional theory of elasticity to model the vibrations.

  19. Influence of Coulomb screening on lateral lasing in VECSELs.

    PubMed

    Wang, Chengao; Malloy, Kevin; Sheik-Bahae, Mansoor

    2015-12-14

    Parasitic lateral lasing in certain optically pumped semiconductor disc lasers drains the gain of the vertical mode and thus causes power scaling degradation and premature rollover in surface emitting operation. We have observed this effect in both multiple quantum wells (MQW) (GaInAs/GaAs) and double heterostructures (DHS) (GaInP/GaAs/GaInP) under pulsed excitation even when the gain chip lateral dimensions are much larger than the diameter of the pump laser. Lateral lasing occurs persistently between cleaved facets at a band-tail wavelength much longer than the peak of the gain. We show that the effect of bandgap renormalization due to Coulomb screening explains this phenomena. Exploiting the simple analytical plasma theory of bulk semiconductors (Banyai & Koch, 1986), we can account for such an effect in double heterostructures. PMID:26699044

  20. Efficacy and Safety of Split Peroneal Tendon Lateral Ankle Stabilization.

    PubMed

    Shibuya, Naohiro; Bazán, D Issac; Evans, Andrew M; Agarwal, Monica R; Jupiter, Daniel C

    2016-01-01

    Chronic lateral ankle instability is a common condition. Split peroneal tendon lateral ankle stabilization, a modification of the Chrisman-Snook procedure, is biomechanically stable and often used for severe and/or recurrent chronic lateral ankle instability. The purpose of the present study was to evaluate the efficacy and safety of this technique. Specifically, the midterm recurrence of instability and postoperative complications, such as stiffness, neurologic pain, and wound healing complications, were evaluated. We evaluated 30 consecutive procedures with a minimal follow-up period of 1 year. The mean follow-up period was 25 ± 13 (median 19, range 13 to 62) months. Five patients (17%) developed recurrent ankle instability, of whom 4 underwent revision surgery. One superficial infection and two wound disruptions developed. Two patients experienced stiffness and eight (27%) surgically induced neurologic complaints, such as sural neuritis. Finally, 2 patients developed complex regional pain syndrome.

  1. Antarctic birds breed later in response to climate change

    PubMed Central

    Barbraud, Christophe; Weimerskirch, Henri

    2006-01-01

    In the northern hemisphere, there is compelling evidence for climate-related advances of spring events, but no such long-term biological time series exist for the southern hemisphere. We have studied a unique data set of dates of first arrival and laying of first eggs over a 55-year period for the entire community of Antarctic seabirds in East Antarctica. The records over this long period show a general unexpected tendency toward later arrival and laying, an inverse trend to those observed in the northern hemisphere. Overall, species now arrive at their colonies 9.1 days later, on average, and lay eggs an average of 2.1 days later than in the early 1950s. Furthermore, these delays are linked to a decrease in sea ice extent that has occurred in eastern Antarctica, which underlies the contrasted effects of global climate change on species in Antarctica. PMID:16601100

  2. Nanoparticle embedded enzymes for improved lateral flow sensors.

    PubMed

    Özalp, Veli C; Zeydanlı, Uğur S; Lunding, Anita; Kavruk, Murat; Öz, M Tufan; Eyidoğan, Füsun; Olsen, Lars F; Öktem, Hüseyin A

    2013-08-01

    In this study, combining the nanoparticle embedded sensors with lateral flow assays, a novel strategy for ensuring the quality of signalling in lateral flow assays (LFAs) was developed. A LFA for reactive oxygen species (ROS) is reported that is based on horse radish peroxidase (HRP) which is co-entrapped with Texas Red dextran inside porous polyacrylamide nanoparticles. In this system, enzymes are protected in the porous matrix of polyacrylamide which freely allows the diffusion of the analyte. The sensor is rapid and sensitive for quantification of hydrogen peroxide concentrations. A test solution of hydrogen peroxides was quantified with this novel LFA-ROS sensor to obtain a linear range between 1 and 25 μM. Nanoparticle embedding of enzymes is proposed here as a general strategy for developing enzyme-based lateral flow assays, eliminating adverse effects associated with biological samples.

  3. Vehicle Lateral State Estimation Based on Measured Tyre Forces

    PubMed Central

    Tuononen, Ari J.

    2009-01-01

    Future active safety systems need more accurate information about the state of vehicles. This article proposes a method to evaluate the lateral state of a vehicle based on measured tyre forces. The tyre forces of two tyres are estimated from optically measured tyre carcass deflections and transmitted wirelessly to the vehicle body. The two remaining tyres are so-called virtual tyre sensors, the forces of which are calculated from the real tyre sensor estimates. The Kalman filter estimator for lateral vehicle state based on measured tyre forces is presented, together with a simple method to define adaptive measurement error covariance depending on the driving condition of the vehicle. The estimated yaw rate and lateral velocity are compared with the validation sensor measurements. PMID:22291535

  4. Persistent exposure to poverty during childhood limits later leader emergence.

    PubMed

    Barling, Julian; Weatherhead, Julie G

    2016-09-01

    Increasing attention is being paid to the question of why some people emerge as leaders, and we investigated the effects of persistent exposure to poverty during childhood on later leadership role occupancy. We hypothesized that exposure to poverty would limit later leadership role occupancy through the indirect effects of the quality of schooling and personal mastery, and that gender would moderate the effects of exposure to poverty and personal mastery. Using the National Longitudinal Study of Youth provided multiwave and multisource data for a sample of 4,536 (1,533 leaders; 3,003 nonleaders). Both school quality and personal mastery mediated the effects of family poverty status on later leadership role occupancy. Although gender did not moderate the effects of poverty on leadership role occupancy, the indirect effects of early exposure to poverty on leadership role occupancy through personal mastery were moderated by gender. Conceptual and practical implications of these findings are discussed. (PsycINFO Database Record

  5. Persistent exposure to poverty during childhood limits later leader emergence.

    PubMed

    Barling, Julian; Weatherhead, Julie G

    2016-09-01

    Increasing attention is being paid to the question of why some people emerge as leaders, and we investigated the effects of persistent exposure to poverty during childhood on later leadership role occupancy. We hypothesized that exposure to poverty would limit later leadership role occupancy through the indirect effects of the quality of schooling and personal mastery, and that gender would moderate the effects of exposure to poverty and personal mastery. Using the National Longitudinal Study of Youth provided multiwave and multisource data for a sample of 4,536 (1,533 leaders; 3,003 nonleaders). Both school quality and personal mastery mediated the effects of family poverty status on later leadership role occupancy. Although gender did not moderate the effects of poverty on leadership role occupancy, the indirect effects of early exposure to poverty on leadership role occupancy through personal mastery were moderated by gender. Conceptual and practical implications of these findings are discussed. (PsycINFO Database Record PMID:27599090

  6. Strategies of Healthy Adults Walking on a Laterally Oscillating Treadmill

    NASA Technical Reports Server (NTRS)

    Brady, Rachel A.; Peters, Brian T.; Bloomberg, Jacob J.

    2008-01-01

    We mounted a treadmill on top of a six degree-of-freedom motion base platform to investigate locomotor responses produced by healthy adults introduced to a dynamic walking surface. The experiment examined self-selected strategies employed by participants when exposed to continuous, sinusoidal lateral motion of the support surface while walking. Torso translation and step width were used to classify responses used to stabilize gait in a novel, dynamic environment. Two response categories emerged. Participants tended to either fix themselves in space (FIS), allowing the treadbelt to move laterally beneath them, or they fixed themselves to the base (FTB), moving laterally as the motion base oscillated. The degree of fixation in both extremes varied across participants. This finding suggests that normal adults have innate and varied preferences for reacquiring gait stability, some depending more heavily on vision (FIS group) and others on proprioception (FTB group). Keywords: Human locomotion, Unstable surface, Treadmill, Adaptation, Stability

  7. Sensitivity of atypical lateral fire spread to wind and slope

    NASA Astrophysics Data System (ADS)

    Simpson, Colin. C.; Sharples, Jason J.; Evans, Jason P.

    2016-02-01

    This study presents new knowledge of the environmental sensitivity of a dynamic mode of atypical wildland fire spread on steep lee-facing slopes. This is achieved through a series of idealized numerical simulations performed with the Weather Research and Forecasting (WRF) and WRF-Fire coupled atmosphere-fire models. The sensitivity of the atypical lateral fire spread across lee slopes is tested for a varying background wind speed, wind direction relative to the terrain aspect, and lee slope steepness. The results indicate that the lateral spread characteristics are highly sensitive to each of these environmental conditions, and there is a broad agreement with the empirical thresholds calculated for lateral spread events observed in the 2003 Canberra bushfires. A theory to explain these environmental thresholds and their apparent interdependency is presented. The results are expected to have important implications for the management of wildland fires in rugged terrain.

  8. Lateral vibration effects in atomic-scale friction

    SciTech Connect

    Roth, R.; Fajardo, O. Y.; Mazo, J. J.; Meyer, E.; Gnecco, E.

    2014-02-24

    The influence of lateral vibrations on the stick-slip motion of a nanotip elastically pulled on a flat crystal surface is studied by atomic force microscopy measurements on a NaCl(001) surface in ultra-high vacuum. The slippage of the nanotip across the crystal lattice is anticipated at increasing driving amplitude, similarly to what is observed in presence of normal vibrations. This lowers the average friction force, as explained by the Prandtl-Tomlinson model with lateral vibrations superimposed at finite temperature. Nevertheless, the peak values of the lateral force, and the total energy losses, are expected to increase with the excitation amplitude, which may limit the practical relevance of this effect.

  9. Nanoparticle embedded enzymes for improved lateral flow sensors.

    PubMed

    Özalp, Veli C; Zeydanlı, Uğur S; Lunding, Anita; Kavruk, Murat; Öz, M Tufan; Eyidoğan, Füsun; Olsen, Lars F; Öktem, Hüseyin A

    2013-08-01

    In this study, combining the nanoparticle embedded sensors with lateral flow assays, a novel strategy for ensuring the quality of signalling in lateral flow assays (LFAs) was developed. A LFA for reactive oxygen species (ROS) is reported that is based on horse radish peroxidase (HRP) which is co-entrapped with Texas Red dextran inside porous polyacrylamide nanoparticles. In this system, enzymes are protected in the porous matrix of polyacrylamide which freely allows the diffusion of the analyte. The sensor is rapid and sensitive for quantification of hydrogen peroxide concentrations. A test solution of hydrogen peroxides was quantified with this novel LFA-ROS sensor to obtain a linear range between 1 and 25 μM. Nanoparticle embedding of enzymes is proposed here as a general strategy for developing enzyme-based lateral flow assays, eliminating adverse effects associated with biological samples. PMID:23730687

  10. Rates of Lateral Gene Transfer in Prokaryotes: High but Why?

    PubMed

    Vos, Michiel; Hesselman, Matthijn C; te Beek, Tim A; van Passel, Mark W J; Eyre-Walker, Adam

    2015-10-01

    Lateral gene transfer is of fundamental importance to the evolution of prokaryote genomes and has important practical consequences, as evidenced by the rapid dissemination of antibiotic resistance and virulence determinants. Relatively little effort has so far been devoted to explicitly quantifying the rate at which accessory genes are taken up and lost, but it is possible that the combined rate of lateral gene transfer and gene loss is higher than that of point mutation. What evolutionary forces underlie the rate of lateral gene transfer are not well understood. We here use theory developed to explain the evolution of mutation rates to address this question and explore its consequences for the study of prokaryote evolution.

  11. The lateral line system of fish as a ``hydrodynamic antenna''

    NASA Astrophysics Data System (ADS)

    Zhang, Jun; Ristroph, Leif; Liao, James

    2013-11-01

    The lateral line of fish is a specialized flow detection system comprised of pressure- and shear-responsive sensors distributed over the body surface. Here, we explore how the arrangement of these sensors is related to the hydrodynamic information contained in flows. Using a cast model of a rainbow trout placed in a water tunnel, we devise ways to mimic the flows encountered by swimming fish while measuring the near-body flow field. Comparing our results to anatomical studies indicates that the lateral line sensors are well positioned to detect temporal and spatial changes in flow signals. These findings support a view of the lateral line as a ``hydrodynamic antenna'' that allows sophisticated behaviors such as rheotaxis and prey detection and tracking.

  12. Pilot opinions of sampling effects in lateral-directional control

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.; Miller, G. E.

    1982-01-01

    Flight experiments with a microprocessor control system were conducted to determine the effects of variations in sampling parameters on several pilots' opinions of lateral-directional flying qualities. Princeton's variable-response research aircraft (VRA), which is equipped with a microprocessor based digital flight control system (Micro-DFCS), was the test vehicle. Two U.S. Navy pilots evaluated the effects of sampling rate, quantization, and pure time delay during tracking, approach, and landing. Aircraft carrier approach tasks were conducted using a Navy approach mirror. Acquisition and tracking of fixed objects on the ground provided additional information related to the Navy misson. The longitudinal controls were implemented with analog electronics, while the lateral-directional pilot inputs (stick and rudder) were fed to the Micro-DFCS, which commanded the ailerons and rudder. The conceptual relationship between the evaluation pilot's lateral-directional inputs, the flight computer, and the aircraft are illustrated.

  13. Paternal programming of offspring cardiometabolic diseases in later life

    PubMed Central

    Li, Jian; Tsuprykov, Oleg; Yang, Xiaoping; Hocher, Berthold

    2016-01-01

    Early – intrauterine – environmental factors are linked to the development of cardiovascular disease in later life. Traditionally, these factors are considered to be maternal factors such as maternal under and overnutrition, exposure to toxins, lack of micronutrients, and stress during pregnancy. However, in the recent years, it became obvious that also paternal environmental factors before conception and during sperm development determine the health of the offspring in later life. We will first describe clinical observational studies providing evidence for paternal programming of adulthood diseases in progeny. Next, we describe key animal studies proving this relationship, followed by a detailed analysis of our current understanding of the underlying molecular mechanisms of paternal programming. Alterations of noncoding sperm micro-RNAs, histone acetylation, and targeted as well as global DNA methylation seem to be in particular involved in paternal programming of offspring's diseases in later life. PMID:27457668

  14. Image enhancement algorithm based on improved lateral inhibition network

    NASA Astrophysics Data System (ADS)

    Yun, Haijiao; Wu, Zhiyong; Wang, Guanjun; Tong, Gang; Yang, Hua

    2016-05-01

    There is often substantial noise and blurred details in the images captured by cameras. To solve this problem, we propose a novel image enhancement algorithm combined with an improved lateral inhibition network. Firstly, we built a mathematical model of a lateral inhibition network in conjunction with biological visual perception; this model helped to realize enhanced contrast and improved edge definition in images. Secondly, we proposed that the adaptive lateral inhibition coefficient adhere to an exponential distribution thus making the model more flexible and more universal. Finally, we added median filtering and a compensation measure factor to build the framework with high pass filtering functionality thus eliminating image noise and improving edge contrast, addressing problems with blurred image edges. Our experimental results show that our algorithm is able to eliminate noise and the blurring phenomena, and enhance the details of visible and infrared images.

  15. LATER models of neural decision behavior in choice tasks

    PubMed Central

    Noorani, Imran

    2014-01-01

    Reaction time has been increasingly used over the last few decades to provide information on neural decision processes: it is a direct reflection of decision time. Saccades provide an excellent paradigm for this because many of them can be made in a very short time and the underlying neural pathways are relatively well-known. LATER (linear approach to threshold with ergodic rate) is a model originally devised to explain reaction time distributions in simple decision tasks. Recently, however it is being extended to increasingly more advanced tasks, including those with decision errors and those requiring voluntary control such as the antisaccade task and those where sequential decisions are required. The strength of this modeling approach lies in its detailed, quantitative predictions of behavior, yet LATER models still retain their conceptual simplicity that made LATER initially successful in explaining reaction times in simple decision tasks. PMID:25202242

  16. Paternal programming of offspring cardiometabolic diseases in later life.

    PubMed

    Li, Jian; Tsuprykov, Oleg; Yang, Xiaoping; Hocher, Berthold

    2016-11-01

    Early - intrauterine - environmental factors are linked to the development of cardiovascular disease in later life. Traditionally, these factors are considered to be maternal factors such as maternal under and overnutrition, exposure to toxins, lack of micronutrients, and stress during pregnancy. However, in the recent years, it became obvious that also paternal environmental factors before conception and during sperm development determine the health of the offspring in later life. We will first describe clinical observational studies providing evidence for paternal programming of adulthood diseases in progeny. Next, we describe key animal studies proving this relationship, followed by a detailed analysis of our current understanding of the underlying molecular mechanisms of paternal programming. Alterations of noncoding sperm micro-RNAs, histone acetylation, and targeted as well as global DNA methylation seem to be in particular involved in paternal programming of offspring's diseases in later life.

  17. Isolated Chronic Exertional Compartment Syndrome of the Lateral Lower Leg

    PubMed Central

    van Zantvoort, Aniek P.M.; de Bruijn, Johan A.; Winkes, Michiel B.; Dielemans, Jeanne P.; van der Cruijsen-Raaijmakers, Marike; Hoogeveen, Adwin R.; Scheltinga, Marc R.

    2015-01-01

    Background: Exercise-induced lower leg pain may be caused by chronic exertional compartment syndrome (CECS). The anterior (ant-CECS) or deep posterior compartment (dp-CECS) is usually affected. Knowledge regarding CECS of the lateral compartment (lat-CECS) is limited. Purpose: To describe demographic characteristics and symptoms in a consecutive series of patients with isolated CECS of the lateral compartment of the leg. Study Design: Case series; Level of evidence, 4. Methods: Since 2001, patients undergoing dynamic intracompartmental pressure (ICP) measurements for suspected CECS in a single institution were prospectively monitored. Individuals with a history possibly associated with lat-CECS and elevated ICP measurements (Pedowitz criteria) were identified. Exclusion criteria were concomitant ipsilateral ant-CECS/dp-CECS, acute compartment syndrome, recent significant trauma, peroneal nerve entrapment, or vascular claudication. Results: During an 11-year time period, a total of 26 patients with isolated lat-CECS fulfilled study criteria (15 females; median age, 21 years; range, 14-48 years). Frequently identified provocative sports were running (n = 4), walking (n = 4), field hockey (n = 3), soccer (n = 3), and volleyball (n = 2). Exercise-induced lateral lower leg pain (92%) and tightness (42%) were often reported. The syndrome was bilateral in almost two-thirds (62%, n = 16). Delay in diagnosis averaged 24 months (range, 2 months to 10 years). Conclusion: Young patients with exercise-induced pain in the lateral portions of the lower leg may suffer from isolated CECS of the lateral compartment. ICP measurements in the lateral compartment in these patients are recommended. PMID:26740955

  18. Landing adaptations following isolated lateral meniscectomy in athletes

    PubMed Central

    Minning, Stephen J.; Myer, Gregory D.; Mangine, Robert E.; Colosimo, Angelo J.; Hewett, Timothy E.

    2014-01-01

    Purpose Objective functional outcomes following isolated radial lateral meniscus tears in the athlete between the ages of 14–25 are not clearly defined. The objective of this study was to determine whether patients following lateral meniscectomy demonstrate lower extremity asymmetries relative to control athletes 3 months after surgery. We hypothesized that following lateral meniscectomy, athletes aged 14–25 years old would demonstrate altered landing biomechanics compared to sex, age, height, weight, and sport-matched controls. Methods A total of 18 subjects were included in this study. Nine patients (7 men and 2 women, 20.1 ± 2.8 years) who had undergone first-time isolated radial lateral meniscus tears were tested 3 months following partial lateral meniscectomies and compared to nine sex, age, height, weight, and sport-matched controls (7 men and 2 women, 19.7 ± 3.1 years). A ten-camera motion analysis system and two force platforms were used to collect three trials of bilateral drop landings. A 2X2 ANOVA was used to test the interaction between side (involved vs. uninvolved) and group (patient vs. control). Results The patient group landed with a decreased internal knee extensor moment compared to the uninvolved side and controls (interaction P < 0.05). The involved limb quadriceps isokinetic torque was not decreased compared to the contralateral or control (n.s.). Decreased knee extensor moments were significantly associated with reduced measures of function (IKDC scores: r = 0.69; P < 0.05). Conclusions Athletes who return to sport at approximately 3 months following a partial lateral meniscectomy may employ compensation strategies during landing as evidenced by reduced quadriceps recruitment and functional outcome scores. Clinicians should focus on improving quadriceps function during landing on the involved leg in an attempt to decrease residual limb asymmetries. Level of evidence Case–control study, Level III. PMID:21468616

  19. Comparison of medial versus lateral meniscus allograft transplantation

    PubMed Central

    Wei, Guo; Liang, Jie; Ru, Neng; Li, Yu-Peng; Shang, Zheng-Hui; Chen, Jian-Feng

    2016-01-01

    Objectives: To perform a literature review and meta-analysis evaluating the effectiveness of medial and lateral meniscus allograft transplantation (MAT). Methods: The literature review and meta-analysis were conducted between August and October 2015 in the People’s Hospital of China Three Gorges University, Yi Chang, China. A systematic search was performed in the Medline and EMBASE databases, and the Cochrane Library for relevant literature published through October 2015. The outcomes of the included studies were analyzed in terms of the Lysholm Score, International Knee Documentation Committee (IKDC) Score, Knee Injury And Osteoarthritis Outcome Score (KOOS), Visual Analog Scale (VAS), Tegner Activity Score, MRI results, and failure rates. An adapted version of the Newcastle-Ottawa Scale was used for the methodological quality assessment in the meta-analyses. Results: The literature review identified 12 observational studies, including 7 retrospective studies, 4 prospective studies, and the nature of one study was not reported. Significant differences in the outcomes of the lateral MAT group and the medial MAT group were observed in the IKDC scores, KOOS pain values, KOOS activities of daily living (ADL) values, and the absolute and relative extrusions observed on MRI, which suggested that the lateral MAT patients experienced superior clinical benefits compared with the medial MAT patients. However, significant differences between the lateral MAT group and the medial MAT group were not observed with regards to the Lysholm Scores, KOOS symptom values, KOOS sports and recreations values, KOOS quality of life (QOL) values, Tegner Activity Scores, VAS for pain values, and failure rates. Conclusion: The analysis results indicated that lateral MAT provides superior clinical outcomes compared with medial MAT according to the KOOS and IKDC scores. In addition, greater graft extrusion was observed in the medial group on MRI. Although significant differences were not

  20. Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients.

    PubMed

    Ehinger, Johannes K; Morota, Saori; Hansson, Magnus J; Paul, Gesine; Elmér, Eskil

    2015-06-01

    Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis, where the progressive degeneration of motor neurons results in muscle atrophy, paralysis and death. Abnormalities in both central nervous system and muscle mitochondria have previously been demonstrated in patient samples, indicating systemic disease. In this case-control study, venous blood samples were acquired from 24 amyotrophic lateral sclerosis patients and 21 age-matched controls. Platelets and peripheral blood mononuclear cells were isolated and mitochondrial oxygen consumption measured in intact and permeabilized cells with additions of mitochondrial substrates, inhibitors and titration of an uncoupler. Respiratory values were normalized to cell count and for two markers of cellular mitochondrial content, citrate synthase activity and mitochondrial DNA, respectively. Mitochondrial function was correlated with clinical staging of disease severity. Complex IV (cytochrome c-oxidase)-activity normalized to mitochondrial content was decreased in platelets from amyotrophic lateral sclerosis patients both when normalized to citrate synthase activity and mitochondrial DNA copy number. In mononuclear cells, complex IV-activity was decreased when normalized to citrate synthase activity. Mitochondrial content was increased in amyotrophic lateral sclerosis patient platelets. In mononuclear cells, complex I activity declined and mitochondrial content increased progressively with advancing disease stage. The findings are, however, based on small subsets of patients and need to be confirmed. We conclude that when normalized to mitochondria-specific content, complex IV-activity is reduced in blood cells from amyotrophic lateral sclerosis patients and that there is an apparent compensatory increase in cellular mitochondrial content. This supports systemic involvement in amyotrophic lateral sclerosis and suggests further study of mitochondrial function in blood cells as a future biomarker for the

  1. Dynamic biomechanics of the human head in lateral impacts

    PubMed Central

    Zhang, Jiangyue; Yoganandan, Narayan; Pintar, Frank A.

    2009-01-01

    The biomechanical responses of human head (translational head CG accelerations, rotational head accelerations, and HIC) under lateral impact to the parietal-temporal region were investigated in the current study. Free drop tests were conducted at impact velocities ranging from 2.44 to 7.70 m/s with a 40 durometer, a 90 durometer flat padding, and a 90 durometer cylinder. Specimens were isolated from PMHS subjects at the level of occipital condyles, and the intracranial substance was replaced with brain simulant (Sylgard 527). Three tri-axial accelerometers were instrumented at the anterior, posterior, and vertex of the specimen, and a pyramid nine accelerometer package (pNAP) was used at the contra-lateral site. Biomechanical responses were computed by transforming accelerations measured at each location to the head CG. The results indicated significant “hoop effect” from skull deformation. Translational head CG accelerations were accurately measured by transforming the pNAP, the vertex accelerations, or the average of anterior/posterior acceleration to the CG. The material stiffness and structural rigidity of the padding changed the biomechanical responses of the head with stiffer padding resulting in higher head accelerations. At the skull fracture, HIC values were more than 2–3x higher than the frontal skull fracture threshold (HIC=1000), emphasizing the differences between frontal and lateral impact. Rotational head accelerations up to 42.1 krad/s2 were observed before skull fracture, indicating possible severe brain injury without skull fracture in lateral head impact. These data will help to establish injury criteria and threshold in lateral impacts for improved automotive protection and help clinicians understand the biomechanics of lateral head impact from improved diagnosis. PMID:20184848

  2. Dynamic biomechanics of the human head in lateral impacts.

    PubMed

    Zhang, Jiangyue; Yoganandan, Narayan; Pintar, Frank A

    2009-10-01

    The biomechanical responses of human head (translational head CG accelerations, rotational head accelerations, and HIC) under lateral impact to the parietal-temporal region were investigated in the current study. Free drop tests were conducted at impact velocities ranging from 2.44 to 7.70 m/s with a 40 durometer, a 90 durometer flat padding, and a 90 durometer cylinder. Specimens were isolated from PMHS subjects at the level of occipital condyles, and the intracranial substance was replaced with brain simulant (Sylgard 527). Three tri-axial accelerometers were instrumented at the anterior, posterior, and vertex of the specimen, and a pyramid nine accelerometer package (pNAP) was used at the contra-lateral site. Biomechanical responses were computed by transforming accelerations measured at each location to the head CG. The results indicated significant "hoop effect" from skull deformation. Translational head CG accelerations were accurately measured by transforming the pNAP, the vertex accelerations, or the average of anterior/posterior acceleration to the CG. The material stiffness and structural rigidity of the padding changed the biomechanical responses of the head with stiffer padding resulting in higher head accelerations. At the skull fracture, HIC values were more than 2-3x higher than the frontal skull fracture threshold (HIC=1000), emphasizing the differences between frontal and lateral impact. Rotational head accelerations up to 42.1 krad/s(2) were observed before skull fracture, indicating possible severe brain injury without skull fracture in lateral head impact. These data will help to establish injury criteria and threshold in lateral impacts for improved automotive protection and help clinicians understand the biomechanics of lateral head impact from improved diagnosis.

  3. Lateral Orbital Wall Destruction Due to Pilonidal Sinus.

    PubMed

    Karadağ, Emine Çiğdem; Toy, Hatice; Tosun, Zekeriya

    2016-07-01

    Pilonidal sinus is a chronic inflammatory disease commonly observed in the sacrococcygeal region. The authors report a patient of a pilonidal sinus in a rare location-the lateral orbital region. The authors' patient was misdiagnosed with an epidermal cyst, and the subsequent incomplete excision of the sinus tract led a pilonidal sinus with a high morbidity resulting in the destruction of bone tissue in the lateral orbital wall. It was, therefore, crucial to accurately diagnose and treat before the infection progressed through the bone and caused osteomyelitis. PMID:27391513

  4. Imaging using lateral bending modes of atomic force microscope cantilevers

    NASA Astrophysics Data System (ADS)

    Caron, A.; Rabe, U.; Reinstädtler, M.; Turner, J. A.; Arnold, W.

    2004-12-01

    Using scanning probe techniques, surface properties such as shear stiffness and friction can be measured with a resolution in the nanometer range. The torsional deflection or buckling of atomic force microscope cantilevers has previously been used in order to measure the lateral forces acting on the tip. This letter shows that the flexural vibration modes of cantilevers oscillating in their width direction parallel to the sample surface can also be used for imaging. These lateral cantilever modes exhibit vertical deflection amplitudes if the cantilever is asymmetric in thickness direction, e.g., by a trapezoidal cross section.

  5. LATERAL GENE TRANSFER AND THE HISTORY OF BACTERIAL GENOMES

    SciTech Connect

    Howard Ochman

    2006-02-22

    The aims of this research were to elucidate the role and extent of lateral transfer in the differentiation of bacterial strains and species, and to assess the impact of gene transfer on the evolution of bacterial genomes. The ultimate goal of the project is to examine the dynamics of a core set of protein-coding genes (i.e., those that are distributed universally among Bacteria) by developing conserved primers that would allow their amplification and sequencing in any bacterial taxa. In addition, we adopted a bioinformatic approach to elucidate the extent of lateral gene transfer in sequenced genome.

  6. Lateral groundwater inflows into alluvial aquifers of main alpine valleys

    NASA Astrophysics Data System (ADS)

    Burger, Ulrich

    2015-04-01

    In alpine regions the topography is mainly characterised by deep incised valleys, mountain slopes and ridges. Usually the main valleys contain aquifers in alluvial soft rock. Lateral these aquifers are confined by mountainous hard rock slopes covered by heterogeneous sediments with different thickness. The slopes can be incised by lateral valleys. Numerical models for the main alluvial aquifers ask for lateral hydrogeological boundaries. Usually no flow boundaries or Constant head Boundaries are used, even if the lateral inflows to the main aquifers are rarely known. In this example a data set for a detailed investigated and monitored area is studied to give an answer on the location and the quantification of these lateral subsurface inflows. The study area is a typical main alpine valley with a thick alluvial aquifer (appr. 120m thick), lateral confined by granite, covered at the base of the steep slopes by quaternary sediments (Burger at al. 2012). The study consists of several steps 1.) Analytical calculation of the inflows on the base of investigated and monitored 2d profiles along fault zones (Perello et al 2013) which pinch out in the main valley 2.) Analytical models along typical W-dipping slopes with monitored slope springs 3.) Evaluating temperature and electrical conductivity profiles measured in approx. 30 groundwater wells in the alluvial aquifers and along the slopes to locate main lateral subsurface inflows 4.) Output of a regional model used for the hydrogeological back analyses of the excavation of a tunnel (Baietto et al. 2014) 5.) Output of a local numerical model calibrated with a monitoring dataset and results of a pumping test of big scale (450l/s for 10days) Results of these analyses are shown to locate and quantify the lateral groundwater inflows in the main alluvial aquifer. References Baietto A., Burger U., Perello P. (2014): Hydrogeological modelling applications in tunnel excavations: examples from tunnel excavations in granitic rocks

  7. Earlier violent television exposure and later drug dependence.

    PubMed

    Brook, David W; Saar, Naomi S; Brook, Judith S

    2008-01-01

    This research examined the longitudinal pathways from earlier violent television exposure to later drug dependence. African American and Puerto Rican adolescents were interviewed during three points in time (n = 463). Exposure to violent television programs in late adolescence predicted exposure to violent television programs in young adulthood, which in turn was related to tobacco/marijuana use, nicotine dependence, and later drug dependence. Some policy and clinical implications suggest regulating the times when violent television programs are broadcast, creating developmentally targeted prevention/treatment programs, and recognizing that watching violent television programs may serve as a cue regarding increased susceptibility to nicotine and drug dependence. PMID:18612881

  8. Doppler-based lateral motion tracking for optical coherence tomography.

    PubMed

    Weiss, Nicolás; van Leeuwen, Ton G; Kalkman, Jeroen

    2012-06-15

    Nonuniform lateral scanning of the probe beam in optical coherence tomography produces imaging artifacts and leads to a morphologically inaccurate representation of the sample. Here, we demonstrate a solution to this problem, which is based on the Doppler shift carried by the complex-valued depth-resolved scattering amplitude. Furthermore, we demonstrate the feasibility of Doppler flow velocity measurements in underlying flow channels while laterally scanning the imaging probe over large surfaces with arbitrary and varying velocity. Finally, we performed centimeters-long hand-held B-mode imaging of skin in vivo.

  9. Non-uniform lateral current distribution in quantum cascade lasers.

    PubMed

    Huang, Xue; Dikmelik, Yamac; Gmachl, Claire

    2014-03-10

    Non-uniform lateral current distribution in quantum cascade (QC) lasers is investigated, as a result of stimulated-optical-emission-assisted electron transport, the rate of which depends on the local photon density and is comparable to the longitudinal optical (LO) phonon scattering rate. A microscopic model based on rate equations is built to study the self-consistent process of interaction between local electrons and photons in QC lasers. The non-uniform distribution of lateral current and the corresponding spatial hole burning are simulated from this model. Moreover, multi-transverse-mode operation in QC lasers is also investigated.

  10. Released micromachined beams utilizing laterally uniform porosity porous silicon

    PubMed Central

    2014-01-01

    Suspended micromachined porous silicon beams with laterally uniform porosity are reported, which have been fabricated using standard photolithography processes designed for compatibility with complementary metal-oxide-semiconductor (CMOS) processes. Anodization, annealing, reactive ion etching, repeated photolithography, lift off and electropolishing processes were used to release patterned porous silicon microbeams on a Si substrate. This is the first time that micromachined, suspended PS microbeams have been demonstrated with laterally uniform porosity, well-defined anchors and flat surfaces. PACS 81.16.-c; 81.16.Nd; 81.16.Rf PMID:25221457

  11. An Improved Method of Manufacturing Corrugated Boxes: Lateral Corrugator

    SciTech Connect

    Frank C. Murray Ph.D.; , Roman Popil Ph.D.; Michael Shaepe

    2008-12-18

    Paper physicists have known that a corrugated box constructed from outer liner sheets having a predominant fiber orientation aligned with the corrugating flute direction would have higher stiffness and crush resistance (per unit of fiber weight) than the conventional box construction. Such increased performance per unit of fiber weight could result in fiber reduction and energy savings for boxes having equivalent performance specifications. The goal of this project was to develop and demonstrate a commercially viable lateral corrugating process. This included designing and building a pilot lateral corrugator, testing and evaluating pilot machine made boxes, and developing a strategy for commercialization.

  12. A rare occurrence of geminated-taloned maxillary lateral incisor.

    PubMed

    Neeraja, R; Kayal, Vizhi G

    2012-05-01

    The talon cusp is a developmental anomaly characterized by the presence of an accessory cusp like structure projecting from the cingulum area of the anterior teeth. Gemination is an anomaly caused by a single tooth germ that attempted to divide during its development. These developmental anomalies may cause clinical problems including esthetic impairment, pain, caries and tooth crowding. Co-occurrence of two anomalies in a teeth is rare. This paper presents an unusual case of talon cusp on geminated permanent lateral incisor. How to cite this article: Neeraja R, Kayal VG. A Rare Occurrence of Geminated-Taloned Maxillary Lateral Incisor. Int J Clin Pediatr Dent 2012;5(2):136-138.

  13. Retroperitoneal approach for lumbar lateral meningocele--case report.

    PubMed

    Miyata, M; Yamasaki, S; Yoshida, T; Matsubara, M; Okamura, M; Hirayama, A; Tamaki, N

    1995-12-01

    A 29-year-old female with neurofibromatosis presented with a right lumbar lateral meningocele. Abdominal computed tomography (CT) showed a huge right retroperitoneal cyst expanding anterolaterally and displacing the right kidney. CT following myelography disclosed the cyst expanding through a wide defect of the right pedicles of the T-12 and L-1 vertebrae. The cyst was resected through a retroperitoneal approach with right flank oblique incision. Postoperatively, cerebrospinal fluid leakage occurred, which improved after lumboperitoneal shunt. Careful screening for lateral meningocele, including the lumbar region, should be undertaken in a patient with neurofibromatosis who presents with vertebral anomalies.

  14. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.

    PubMed

    Saberi, Shahram; Stauffer, Jennifer E; Schulte, Derek J; Ravits, John

    2015-11-01

    The neuropathologic molecular signature common to almost all sporadic amyotrophic lateral sclerosis (ALS) and most familial ALS is TDP-43 immunoreactive neuronal cytoplasmic inclusions. The neuropathologic and molecular neuropathologic features of ALS variants, primarily lateral sclerosis and progressive muscular atrophy, are less certain but also seem to share the primary features of ALS. Genetic causes, including mutations in SOD1, TDP-43, FUS, and C9orf72, all have distinctive molecular neuropathologic signatures. Neuropathology will continue to play an increasingly key role in solving the puzzle of ALS pathogenesis.

  15. Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities.

    PubMed

    Clark, Rosemary; Blizzard, Catherine; Dickson, Tracey

    2015-12-01

    In amyotrophic lateral sclerosis, motor neuron hyperexcitability and inhibitory dysfunction is emerging as a potential causative link in the dysfunction and degeneration of the motoneuronal circuitry that characterizes the disease. Interneurons, as key regulators of excitability, may mediate much of this imbalance, yet we know little about the way in which inhibitory deficits perturb excitability. In this review, we explore inhibitory control of excitability and the potential contribution of altered inhibition to amyotrophic lateral sclerosis disease processes and vulnerabilities, identifying important windows of therapeutic opportunity and potential interventions, specifically targeting inhibitory control at key disease stages.

  16. Band engineering in transition metal dichalcogenides: Stacked versus lateral heterostructures

    NASA Astrophysics Data System (ADS)

    Guo, Yuzheng; Robertson, John

    2016-06-01

    We calculate a large difference in the band alignments for transition metal dichalcogenide (TMD) heterojunctions when arranged in the stacked layer or lateral (in-plane) geometries, using direct supercell calculations. The stacked case follows the unpinned limit of the electron affinity rule, whereas the lateral geometry follows the strongly pinned limit of alignment of charge neutrality levels. TMDs therefore provide one of the few clear tests of band alignment models, whereas three-dimensional semiconductors give less stringent tests because of accidental chemical trends in their properties.

  17. Resume and analysis of NACA lateral control research

    NASA Technical Reports Server (NTRS)

    Weick, Fred E; Jones, Robert T

    1937-01-01

    An analysis of the principal results of recent NACA lateral control research is made by utilizing the experience and progress gained during the course of the investigation. Two things are considered of primary importance in judging the effectiveness of different control devices: the (calculated) banking and yawing motion of a typical small airplane caused by a deflection of the control, and the stick force required to produce this deflection. The report includes a table in which a number of different lateral control devices are compared on these bases.

  18. Lateral electronic screening in quasi-one-dimensional plasmons

    NASA Astrophysics Data System (ADS)

    Lichtenstein, T.; Tegenkamp, C.; Pfnür, H.

    2016-09-01

    The properties of one-dimensional (1D) plasmons are rather unexplored. We investigated the plasmonic collective excitations, measured as one-dimensional plasmon dispersions with electron energy loss spectroscopy, highly resolved both in energy and lateral momentum, for both phases of Au induced chains on stepped Si(553) substrates. We observe 1D dispersions that are strongly influenced by the lateral chain width and by the interchain coupling. Indications for the existence of two different plasmons originating from two surface bands of the systems are given for the low coverage phase.

  19. Evaluation of importance of lateral acceleration derivatives in extraction of lateral-directional derivatives at high angles of attack

    NASA Technical Reports Server (NTRS)

    Nguyen, L. T.

    1974-01-01

    A theoretical investigation was conducted to determine the importance of the lateral acceleration (beta) derivatives in the extraction of lateral-directional stability derivatives for swept wing airplanes at high angles of attack. Representative values of lateral acceleration derivatives in yaw and roll (Cn beta and Cl beta) were used in a computer program to generate representative flight motions at several angles of attack and altitudes. The computer-generated motions were then subjected to a parameter identification process based on a modified Newton-Raphson method. Two identification techniques were evaluated, one which included the beta derivatives and one which neglected them. The results of the study indicate that omission of the beta derivatives from mathematical models used in the derivative-extraction techniques can produce erroneous values for the lateral-directional stability derivatives particularly at high angles of attack, where the beta derivatives are large. The largest errors occur in the dynamic derivatives, but large errors may also occur in the static derivatives for cases in which the beta derivatives have large effects on the flight motions of the airplane. In addition, the resulting identified mathematical models provide poor motion prediction as well as erroneous predictions of dynamic modal characteristics. These results strongly indicate that the effects of beta derivatives should be considered in any attempt to extract lateral-directional aerodynamic parameters at high angles of attack.

  20. 14 CFR 23.147 - Directional and lateral control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Directional and lateral control. 23.147 Section 23.147 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... critical engine, making allowance for a delay of two seconds in the initiation of recovery...

  1. Transitions into and out of Cohabitation in Later Life

    ERIC Educational Resources Information Center

    Brown, Susan L.; Bulanda, Jennifer Roebuck; Lee, Gary R.

    2012-01-01

    Cohabitation among adults over age 50 is rising rapidly, more than doubling from 1.2 million in 2000 to 2.75 million in 2010. A small literature provides a descriptive portrait of older cohabitors, but no study has investigated transitions into and out of cohabitation during later life. Drawing on demographic and life course perspectives, the…

  2. Lateral and Anterior Thalamic Lesions Impair Independent Memory Systems

    ERIC Educational Resources Information Center

    Mitchell, Anna S.; Dalrymple-Alford, John C.

    2006-01-01

    Damage to the medial region of the thalamus, both in clinical cases (e.g., patients with infarcts or the Korsakoff's syndrome) and animal lesion models, is associated with variable amnesic deficits. Some studies suggest that many of these memory deficits rely on the presence of lateral thalamic lesions (LT) that include the intralaminar nuclei,…

  3. Modeling, Simulation, and Parameter Estimation of Lateral Spacecraft Fuel Slosh

    NASA Technical Reports Server (NTRS)

    Chatman, Yadira; Gangadharan, Sathya; Marsell, Brandon; Schlee, Keith; Sudermann, James; Walker, Charles; Ristow, James

    2008-01-01

    Predicting the effect of fuel slosh on a spacecraft and/or launch vehicle attitude control system is a very important and a challenging task. Whether the spacecraft is under spinning or lateral moving conditions, the dynamic effect of the fuel slosh will help determine whether the spacecraft will remain on its chosen trajectory. There are three categories of slosh that can be caused by launch vehicle and/or spacecraft maneuvers when the fuel is in the presence of an acceleration field. These include bulk fluid motion, subsurface wave motion, and free surface slosh. Each of these slosh types have a periodic component that is defined by either a spinning or lateral motion. For spinning spacecraft, all three types of slosh can play a major role in determining stability. Bulk fluid motion and free surface slosh can affect the lateral slosh characteristics. For either condition, the possibility for an unpredicted coupled resonance between the spacecraft and its on board fuel can have mission threatening affects. This on-going research effort aims at improving the accuracy and efficiency of modeling techniques used to predict these types of lateral fluid motions. In particular, efforts will focus on analyzing the effects of viscoelastic diaphragms on slosh dynamics.

  4. 45 CFR 92.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Later disallowances and adjustments. 92.51 Section 92.51 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION UNIFORM... requirements in §§ 92.31 and 92.32; and (e) Audit requirements in § 92.26....

  5. 45 CFR 92.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Later disallowances and adjustments. 92.51 Section 92.51 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION UNIFORM... requirements in §§ 92.31 and 92.32; and (e) Audit requirements in § 92.26....

  6. 45 CFR 92.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Later disallowances and adjustments. 92.51 Section 92.51 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION UNIFORM... requirements in §§ 92.31 and 92.32; and (e) Audit requirements in § 92.26....

  7. SENSORY HAIR CELL REGENERATION IN THE ZEBRAFISH LATERAL LINE

    PubMed Central

    Lush, Mark E.; Piotrowski, Tatjana

    2014-01-01

    Damage or destruction of sensory hair cells in the inner ear leads to hearing or balance deficits that can be debilitating, especially in older adults. Unfortunately, the damage is permanent, as regeneration of the inner ear sensory epithelia does not occur in mammals. Zebrafish and other non-mammalian vertebrates have the remarkable ability to regenerate sensory hair cells and understanding the molecular and cellular basis for this regenerative ability will hopefully aid us in designing therapies to induce regeneration in mammals. Zebrafish not only possess hair cells in the ear but also in the sensory lateral line system. Hair cells in both organs are functionally analogous to hair cells in the inner ear of mammals. The lateral line is a mechanosensory system found in most aquatic vertebrates that detects water motion and aids in predator avoidance, prey capture, schooling and mating. Although hair cell regeneration occurs in both the ear and lateral line, most research to date has focused on the lateral line due to its relatively simple structure and accessibility. Here we review the recent discoveries made during the characterization of hair cell regeneration in zebrafish. PMID:25045019

  8. Irreducible Lateral Patellar Dislocation: A Case Report and Literature Review

    PubMed Central

    Grewal, Balvinder; Elliott, Devlin; Daniele, Luca; Reidy, James

    2016-01-01

    Background: Acute patellar dislocation is a common injury in young people, especially in adolescent females and athletes. Lateral dislocation is the most common form of patellar dislocation and often reduces spontaneously or with simple manipulation and closed reduction. We report a rare circumstance in which the patella was irreducible and required manipulation and closed reduction in the operating room. Case Report: While dancing, a 32-year-old female was knocked by a fellow dancer on her left knee, and she fell to the nightclub floor. She was unable to stand or bear weight because of the pain, and her knee was in fixed flexion with lateral displacement of the patella. Multiple attempts at closed reduction under sedation failed in the emergency department. Computed tomography (CT) images revealed a medial border patellar fracture and lipohemarthrosis that required closed reduction and manipulation in the operating room. The patient was placed in a Richards splint for follow-up and referred to a physiotherapist for conservative management. Conclusion: This case highlights the fact that some lateral patellar dislocations are irreducible on initial attempts, particularly if a fracture is present or another mechanism of impingement impedes relocation. CT imaging is a valuable diagnostic tool, and manipulation under anesthesia or open reduction in the operating room may be necessary. Our review of the literature further highlights the complexity and potential problems associated with treatment of locked lateral patellar dislocations. PMID:27303231

  9. Language Lateralization in Children Using Functional Transcranial Doppler Sonography

    ERIC Educational Resources Information Center

    Haag, Anja; Moeller, Nicola; Knake, Susanne; Hermsen, Anke; Oertel, Wolfgang H.; Rosenow, Felix; Hamer, Hajo M.

    2010-01-01

    Aim: Language lateralization with functional transcranial Doppler sonography (fTCD) and lexical word generation has been shown to have high concordance with the Wada test and functional magnetic resonance imaging in adults. We evaluated a nonlexical paradigm to determine language dominance in children. Method: In 23 right-handed children (12…

  10. Ethylene-Induced Lateral Expansion in Etiolated Pea Stems 1

    PubMed Central

    Taiz, Lincoln; Rayle, David L.; Eisinger, William

    1983-01-01

    Ethylene-induced inhibition of elongation and promotion of lateral expansion in the stems of etiolated pea (Pisum sativum L. var Alaska) seedlings is not associated with any alteration of auxin-stimulated proton extrusion. Indeed, lateral expansion in response to ethylene apparently requires an acidified wall since it is prevented by strong neutral buffers and by the ATPase inhibitor orthovanadate. Ethylene treatment reduces the capacity of live and frozen-thawed sections to extend in the longitudinal direction in response to acid. The effect of ethylene on lateral acid growth capacity is more complicated. Ethylene-treated internodes do not exhibit acid-induced lateral expansion. Ethylene-treated segments which have been frozen-thawed do show an enhanced capacity to extend in the transverse direction at acid pH, but only when the inner tissues have been removed by coring. We conclude that two of the factors which control the directionality of expansion during ethylene treatment are a decrease in the sensitivity of the walls to acid longitudinally and an increase in the sensitivity of the outer cortical parenchyma walls to acid in the transverse direction. PMID:16663230

  11. Cyriax physiotherapy for tennis elbow/lateral epicondylitis.

    PubMed

    Stasinopoulos, D; Johnson, M I

    2004-12-01

    Tennis elbow or lateral epicondylitis is one of the most common lesions of the arm with a well defined clinical presentation, which significantly impacts on the community. Many treatment approaches have been proposed to manage this condition. One is Cyriax physiotherapy. The effectiveness and reported effects of this intervention are reviewed.

  12. A Comparison of Two Lateral Inhibitory Models of Metacontrast.

    PubMed

    Bridgeman, Bruce

    2001-10-01

    Metacontrast, an apparent reduction in brightness of a target that is followed by a non-overlapping mask, has been modeled with simulated neural nets incorporating either recurrent lateral inhibition or forward and backward inhibition with lateral components. A one-layer lateral inhibitory model (B. Bridgeman, 1971, Psychological Review 78, 528-539) and a six-layer model (G. Francis, 1997, Psychological Review 104, 572-594) both simulate the basic metacontrast effect, showing that stimulus-dependent activity that reverberates for some time in the model after stimulus offset is essential to simulate metacontrast. The six-layer model does not simulate monotonic masking with low response criterion, an essential property of metacontrast; the lateral inhibitory model uses duration of reverberation to simulate the criterion. Each model simulates several variations of masking, such as changing the relative energy of target and mask, but neither can handle effects of practice or attention that apparently engage higher processing levels. Copyright 2001 Academic Press.

  13. Hormonal Control of Lateral Root and Nodule Development in Legumes

    PubMed Central

    Bensmihen, Sandra

    2015-01-01

    Many plants can establish symbioses with nitrogen-fixing bacteria, some of which lead to nodulation, including legumes. Indeed, in the rhizobium/legume symbiosis, new root organs, called nodules, are formed by the plant in order to host the rhizobia in protective conditions, optimized for nitrogen fixation. In this way, these plants can benefit from the reduction of atmospheric dinitrogen into ammonia by the hosted bacteria, and in exchange the plant provides the rhizobia with a carbon source. Since this symbiosis is costly for the plant it is highly regulated. Both legume nodule and lateral root organogenesis involve divisions of the root inner tissues, and both developmental programs are tightly controlled by plant hormones. In fact, most of the major plant hormones, such as auxin, cytokinins, abscisic acid, and strigolactones, control both lateral root formation and nodule organogenesis, but often in an opposite manner. This suggests that the sensitivity of legume plants to some phytohormones could be linked to the antagonism that exists between the processes of nodulation and lateral root formation. Here, we will review the implication of some major phytohormones in lateral root formation in legumes, compare them with their roles in nodulation, and discuss specificities and divergences from non-legume eudicot plants such as Arabidopsis thaliana. PMID:27135340

  14. 12. SOUTHWEST VIEW OF FIRST CENTRE FAMILY DWELLING HOUSE, LATER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. SOUTHWEST VIEW OF FIRST CENTRE FAMILY DWELLING HOUSE, LATER FARMER DEACON'S SHOP, WITH SECOND CENTRE FAMILY DWELLING HOUSE IN BACKGROUND - Shaker Centre Family Dwelling House (First), North side of Village Road, North of U.S. Route 68 & State Route 33 intersection, Shakertown, Mercer County, KY

  15. Planning in Middle Childhood: Early Predictors and Later Outcomes

    ERIC Educational Resources Information Center

    Friedman, Sarah L.; Scholnick, Ellin K.; Bender, Randall H.; Vandergrift, Nathan; Spieker, Susan; Pasek, Kathy Hirsh; Keating, Daniel P.; Park, Yoonjung

    2014-01-01

    Data from 1,364 children and families who participated in the National Institute of Child Health and Human Development's Study of Early Child Care and Youth Development were analyzed to track the early correlates and later academic outcomes of planning during middle childhood. Maternal education, through its effect on parenting quality when…

  16. TIBIOTARSAL COMPRESSION ARTHRODESIS USING A LATERAL LOCKING PLATE

    PubMed Central

    Coughlin, Michael J.; Nery, Caio; Baumfeld, Daniel; Jastifer, James

    2015-01-01

    Objectives: Tibiotalar (TT) arthrodesis is still a very important option in the treatment of primary or post-traumatic arthritis of the ankle but persists the controversy regarding the optimal method for the fixation of the arthrodesis site. No matter the implant used, the goal is to obtain a solid, healthy, pain-free fusion. The purpose of the current study is to present the preliminary results of a novel laterally based tibiotalar compression arthrodesis system using a locked plate. Methods: Thirteen consecutive patients with tibiotalar arthritis were submitted to an arthrodesis using a new lateral plating system. The average age was 59.7 years (range 36~72); nine patients were male and four female. Using a cutting guide, the remaining articular surfaces of the tibia and talus were removed. A compression device was applied to avoid malalignment of the ankle and a precontoured lateral locking plate was used to achieve the joint fusion. Results: Both the AOFAS ankle-hindfoot score and the VAS score improved with the surgery. All patients’ ankles fused by 6 months. In all patients we found a very good alignment in the sagittal, coronal and transverse planes. Conclusion: We believe that a combination of a bilateral compression, contoured bony cuts, and lateral locked plating offers a novel, accurate and useful technique for ankle arthrodesis. PMID:27047874

  17. A review of lateralization of spatial functioning in nonhuman primates.

    PubMed

    Oleksiak, Anna; Postma, Albert; van der Ham, Ineke J M; Klink, P Christiaan; van Wezel, Richard J A

    2011-06-24

    The majority of research on functional cerebral lateralization in primates revolves around vocal abilities, addressing the evolutionary origin of the human language faculty and its predominance in the left hemisphere of the brain. Right hemisphere specialization in spatial cognition is commonly reported in humans. This functional asymmetry is especially evident in the context of the unilateral neglect, a deficit in attention to and awareness of one side of space, that more frequently occurs after right-side rather than left-side brain damage. Since most of the research efforts are concentrated on vocalization in primates, much less is known about the presence or absence of spatial functions lateralization. Obtaining this knowledge can provide insight into the evolutionary aspect of the functionally lateralized brain of Homo sapiens and deliver refinement and validation of the nonhuman primate unilateral neglect model. This paper reviews the literature on functional brain asymmetries in processing spatial information, limiting the search to nonhuman primates, and concludes there is no clear evidence that monkeys process spatial information with different efficiency in the two hemispheres. We suggest that lateralization of spatial cognition in humans represents a relatively new feature on the evolutionary time scale, possibly developed as a by-product of the left hemisphere intrusion of language competence. Further, we argue that the monkey model of hemispatial neglect requires reconsideration. PMID:21059373

  18. Why segment the maxilla between laterals and canines?

    PubMed Central

    Esteves, Lucas Senhorinho; dos Santos, Jean Nunes; Sullivan, Steven M.; Martins, Luana Maria Rosário; Ávila, Carolina

    2016-01-01

    Introduction: Maxillary surgery on a bone segment enables movement in the sagittal and vertical planes. When performed on multiple segments, it further provides movement in the transverse plane. Typical sites for interdental osteotomies are between laterals and canines, premolars and canines, or between incisors. Additionally, osteotomies can be bilateral, unilateral or asymmetric. The ability to control intercanine width, buccolingual angulation of incisors, and correct Bolton discrepancy are some of the advantages of maxillary segmentation between laterals and canines. Objective: This article describes important features to be considered in making a clinical decision to segment the maxilla between laterals and canines when treating a dentoskeletal deformity. It further discusses the history of this surgical approach, the indications for its clinical use, the technique used to implement it, as well as its advantages, disadvantages, complications and stability. It is therefore hoped that this paper will contribute to disseminate information on this topic, which will inform the decision-making process of those professionals who wish to make use of this procedure in their clinical practice. Conclusions: Segmental maxillary osteotomy between laterals and canines is a versatile technique with several indications. Furthermore, it offers a host of advantages compared with single-piece osteotomy, or between canines and premolars. PMID:27007769

  19. Repair and reconstruction of the lateral ulnar collateral ligament.

    PubMed

    Bonnaig, Nicholas S; Throckmorton, Thomas Quin

    2015-01-01

    Lateral ulnar collateral ligament repair and reconstruction are techniques used to treat posterolateral rotatory instability of the elbow. The choice to perform repair versus reconstruction is typically dependent on the chronicity of the injury and the quality of tissue available at the time of surgery.

  20. 5. Photocopy of site plan drawing, with later amendments dhowing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of site plan drawing, with later amendments dhowing original USFS building shceduled for removal, Annex moved to present location, and addition to Warehouse (from the U.S. Forest Service, Wenatchee National Forest) Date Unkown - U.S. Forest Service Chelan Ranger Station, 428 West Woodin Avenue, Chelan, Chelan County, WA