KSC-2014-2617

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2623

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- The flame trench comes into view on Launch Pad 39A as a crawler-transporter hauls Mobile Launcher Platform-2, or MLP-2, off the pad at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2619

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter nears the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2618

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter creeps toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2620

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter rolls under the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2624

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, rolling away from Launch Pad 39A atop a crawler-transporter, was positioned over the pad's flame trench only moments before. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2627

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- The crawler-transporter transporting Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A creeps along the crawlerway toward the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KENNEDY SPACE CENTER, FLA. - The crawler-transporter carrying Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, crawls to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. From this perspective, the Launch Control Center (left) and the 525-foot-tall Vehicle Assembly Building (right) in the background appear dwarfed by the 184-foot-tall boosters. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - The crawler-transporter carrying Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, crawls to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. From this perspective, the Launch Control Center (left) and the 525-foot-tall Vehicle Assembly Building (right) in the background appear dwarfed by the 184-foot-tall boosters. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - A crawler-transporter carrying Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, crawls to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. From this perspective, the Launch Control Center (left) and the 525-foot-tall Vehicle Assembly Building (right) in the background appear dwarfed by the 184-foot-tall boosters. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - A crawler-transporter carrying Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, crawls to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. From this perspective, the Launch Control Center (left) and the 525-foot-tall Vehicle Assembly Building (right) in the background appear dwarfed by the 184-foot-tall boosters. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (on the horizon) and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (on the horizon) and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (framed between the boosters), and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (framed between the boosters), and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, along the crawlerway in support of engineering analysis vibration tests on the crawler and MLP. In the distance, at left, is Launch Pad 39A. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, along the crawlerway in support of engineering analysis vibration tests on the crawler and MLP. In the distance, at left, is Launch Pad 39A. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, crawls away from the Vehicle Assembly Building in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, crawls away from the Vehicle Assembly Building in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch away from the Vehicle Assembly Building (VAB) in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch away from the Vehicle Assembly Building (VAB) in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KSC-2014-2625

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, is glimpsed across the water as it departs Launch Pad 39A atop a crawler-transporter. A pad on Cape Canaveral Air Force Station is in view in the background. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. On either side of the boosters on the horizon can be seen the two launch pads. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. On either side of the boosters on the horizon can be seen the two launch pads. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician monitors the performance of a crawler-transporter as it moves Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, to the intersection in the crawlerway during the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A, and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician monitors the performance of a crawler-transporter as it moves Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, to the intersection in the crawlerway during the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A, and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician walks towards the intersection of the crawlerway beside a crawler-transporter moving Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, during the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A, and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician walks towards the intersection of the crawlerway beside a crawler-transporter moving Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, during the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A, and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (on the horizon at right; Pad 39B is at far left), and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A (on the horizon at right; Pad 39B is at far left), and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. In the distance, at left, is Launch Pad 39A. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. In the distance, at left, is Launch Pad 39A. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician inspects the shoes on one of eight tracks of a crawler-transporter (CT). The CT is moving Mobile Launcher Platform (MLP) number 3 with a set of twin solid rocket boosters bolted on top to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - A Kennedy Space Center technician inspects the shoes on one of eight tracks of a crawler-transporter (CT). The CT is moving Mobile Launcher Platform (MLP) number 3 with a set of twin solid rocket boosters bolted on top to the intersection in the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The view reveals the river gravel surface that is 4 inches thick on the straightaway sections and 8 inches thick on curves. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Mobile Launcher Platform (MLP) number 3 and a set of twin solid rocket boosters, atop the crawler-transporter, inch along the crawlerway in support of the second engineering analysis vibration test on the crawler and MLP. The view reveals the river gravel surface that is 4 inches thick on the straightaway sections and 8 inches thick on curves. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Viewed across the turn basin in the Launch Complex 39 Area, the crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB). The journey is in support of engineering analysis vibration tests on the crawler and MLP. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - Viewed across the turn basin in the Launch Complex 39 Area, the crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB). The journey is in support of engineering analysis vibration tests on the crawler and MLP. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

DETAIL VIEW OF A VIDEO CAMERA POSITIONED ALONG THE PERIMETER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF A VIDEO CAMERA POSITIONED ALONG THE PERIMETER OF THE MLP - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

KSC-00padig051

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- With the early morning light behind it, Space Shuttle Endeavour appears to fill the opening in the Vehicle Assembly Building as it begins rollout to Launch Pad 39B on the Mobile Launcher Platform (MLP). At the bottom can be seen the crawler-transporter that moves the combined Shuttle and MLP. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig051

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- With the early morning light behind it, Space Shuttle Endeavour appears to fill the opening in the Vehicle Assembly Building as it begins rollout to Launch Pad 39B on the Mobile Launcher Platform (MLP). At the bottom can be seen the crawler-transporter that moves the combined Shuttle and MLP. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

Space Shuttle Crawler Transporter Vibration Analysis in Support of Rollout Fatigue Load Spectra Verification Program

NASA Technical Reports Server (NTRS)

Margasahayam, Ravi N.; Meyer, Karl A.; Nerolich, Shaun M.; Burton, Roy C.; Gosselin, Armand M.

2004-01-01

The Crawler Transporter (CT), designed and built for the Apollo Program in the 1960's and surpassing its initial operational life, has become an integral part of the Space Shuttle Program (SSP). The CT transports the Space Shuttle Vehicle (SSV) stack, atop the Mobile Launch Platform (MLP), from the Vehicle Assembly Building (VAB) to the launch pad. This support structure provides hydraulic jacking, leveling and load equalization for the 12 million pound stack on its 3.5-5.0 mile rollout to the launch pad. Major elements of the SSV, consisting of the orbiter, solid rocket boosters (SRB) and external tank (ET) have required fatigue analyses as part of the mission life certification. Compared to rollout vibration, the SSV sees relatively high vibration loads during launch, ascent, descent and landing phases of the mission. Although preliminary measured SRB vibration levels during rollout were of low amplitude and frequency, the duration of the rollout phase is typically high, from 5-6 hours. As part of an expanded mission life assessment, additional certification effort was initiated to define fatigue load spectra for rollout. This study addresses the CT vibration analyses in support of the rollout fatigue study. Structural models developed for modal and vibration analyses were used to identify unique CT, CT/MLP and CT/MLP/SRB vibration characteristics for comparison to instrumented rollout tests. Whereas the main structural and vibration characteristics of the SSV are well defined, minimum analytical and vibration test data on the Crawler Transporter were available. Unique vibration characteristics of the CT are attributable to the drive mechanism, hydraulic jacking system, structural framing and the CT-to-MLP support pad restraints. Initial tests performed on the CT/MLP/SRB configuration showed reasonable correlation with predicted mode shapes and frequencies.

KSC-00padig059

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour and the Mobile Launcher Platform (MLP) start backing through the gate to Launch Pad 39B after a cracked cleat was discovered on the crawler-transporter. Workers near the pad (behind the crawler track) look at the cleats. The vehicle, which moves the MLP and Shuttle at about 1 mph, has a leveling system designed to keep the top of the Space Shuttle vertical while negotiating the 5 percent grade leading to the top of the pad. When the Shuttle-MLP are back on level ground, the crawler tracks will be inspected and the broken cleat repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig059

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour and the Mobile Launcher Platform (MLP) start backing through the gate to Launch Pad 39B after a cracked cleat was discovered on the crawler-transporter. Workers near the pad (behind the crawler track) look at the cleats. The vehicle, which moves the MLP and Shuttle at about 1 mph, has a leveling system designed to keep the top of the Space Shuttle vertical while negotiating the 5 percent grade leading to the top of the pad. When the Shuttle-MLP are back on level ground, the crawler tracks will be inspected and the broken cleat repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KENNEDY SPACE CENTER, FLA. -Crawler-transporter (CT) number 2, moves away from the Vehicle Assembly Building, with a Mobile Launcher Platform on top, on a test run to the launch pad. The CT recently underwent modifications to the cab. The CT moves Space Shuttle vehicles between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds.

NASA Image and Video Library

2003-08-18

KENNEDY SPACE CENTER, FLA. -Crawler-transporter (CT) number 2, moves away from the Vehicle Assembly Building, with a Mobile Launcher Platform on top, on a test run to the launch pad. The CT recently underwent modifications to the cab. The CT moves Space Shuttle vehicles between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds.

Time-Accurate Computational Fluid Dynamics Simulation of a Pair of Moving Solid Rocket Boosters

NASA Technical Reports Server (NTRS)

Strutzenberg, Louise L.; Williams, Brandon R.

2011-01-01

Since the Columbia accident, the threat to the Shuttle launch vehicle from debris during the liftoff timeframe has been assessed by the Liftoff Debris Team at NASA/MSFC. In addition to engineering methods of analysis, CFD-generated flow fields during the liftoff timeframe have been used in conjunction with 3-DOF debris transport methods to predict the motion of liftoff debris. Early models made use of a quasi-steady flow field approximation with the vehicle positioned at a fixed location relative to the ground; however, a moving overset mesh capability has recently been developed for the Loci/CHEM CFD software which enables higher-fidelity simulation of the Shuttle transient plume startup and liftoff environment. The present work details the simulation of the launch pad and mobile launch platform (MLP) with truncated solid rocket boosters (SRBs) moving in a prescribed liftoff trajectory derived from Shuttle flight measurements. Using Loci/CHEM, time-accurate RANS and hybrid RANS/LES simulations were performed for the timeframe T0+0 to T0+3.5 seconds, which consists of SRB startup to a vehicle altitude of approximately 90 feet above the MLP. Analysis of the transient flowfield focuses on the evolution of the SRB plumes in the MLP plume holes and the flame trench, impingement on the flame deflector, and especially impingment on the MLP deck resulting in upward flow which is a transport mechanism for debris. The results show excellent qualitative agreement with the visual record from past Shuttle flights, and comparisons to pressure measurements in the flame trench and on the MLP provide confidence in these simulation capabilities.

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, SECTIONS I. Sheet A17 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, SECTIONS II. Sheet A18 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, SECTIONS IV. Sheet A20 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. ISOMETRIC VIEW: MLP NO. 1. Sheet A10 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

KSC-00padig058

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Inside the gate to Launch Pad 39B, Space Shuttle Endeavour and the Mobile Launcher Platform (MLP) start up the incline to the top of the pad. The crawler-transporter beneath the MLP, which moves the Shuttle at about 1 mph, has a leveling system designed to keep the top of the Space Shuttle vertical while negotiating the 5 percent grade leading to the top of the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1623

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour appears dwarfed by the structures inside the Vehicle Assembly Building as it begins rollout to Launch Pad 39B. The Shuttle rests on top of the Mobile Launcher Platform (MLP). Underneath (bottom of photo) is the crawler-transporter that will move the Shuttle and MLP to the pad on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, ELEVATION – SIDE 1 & 2. Sheet A15 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, PLAN – DECK A. Sheet A13 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, ELEVATION – SIDE 3 & 4. Sheet A16 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, PLAN – DECK B. Sheet A14 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, PLAN – DECK 0. Sheet A12 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

KSC VAB Aeroacoustic Hazard Assessment

DTIC Science & Technology

2010-07-01

a Mobile Launch Platform (MLP). Several platform levels are used to perform processing operations and will too be reused and/or modified. Each HB is...I/V Flight Vehicles and the VAB The shell is made up of hundreds of aluminum “punch-out” panels which are designed to fail above approximately 100...into several slices which are converted to monopole sources (see figure below). Figure 3: Plume conversion into acoustic sources [2] The

KSC-03PD-3163

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. A Kennedy Space Center technician walks towards the intersection of the crawlerway beside a crawler-transporter moving Mobile Launcher Platform (MLP) number 3, with a set of twin solid rocket boosters bolted atop, during the second engineering analysis vibration test on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB, travels toward Launch Pad 39A, and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KSC-2014-2615

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter rolls toward Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

View of the Endeavour moving towards it launch pad

NASA Image and Video Library

1996-06-06

STS077-S-044 (16 April 1996) --- The Space Shuttle Endeavour atop the Mobile Launcher Platform and Crawler-Transporter (MLP/CT) slowly lumbers past a tree alongside the crawlerway, at the Kennedy Space Center (KSC). The journey from the Vehicle Assembly Building (VAB) to Launch Pad 39B will take about five to six hours to complete. Once hard down at the pad, preparations will continue to ready Endeavour for its upcoming spaceflight on STS-77.

KSC-2009-2301

NASA Image and Video Library

2009-03-25

CAPE CANAVERAL, Fla. – NASA's Kennedy Space Center management host a ceremony near Launch Pad 39B to mark the handover of Mobile Launcher Platform-1 (behind them) from NASA's Space Shuttle Program to the Constellation Program for the Ares I-X flight test targeted for this summer. Seated are (left) Shuttle Launch Director Mike Leinbach and (right) Pepper E. Phillips, director of the Constellation Project Office, and Brett Raulerson, manager of MLP Operations with United Space Alliance. At the podium is Rita Willcoxon, director of Launch Vehicle Processing at Kennedy. Constructed in 1964, the mobile launchers used in Apollo/Saturn operations were modified for use in shuttle operations. With cranes, umbilical towers and swing arms removed, the mobile launchers were renamed Mobile Launcher Platforms, or MLPs. Photo credit: NASA/Kim Shiflett

KSC-03PD-3128

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Viewed across the turn basin in the Launch Complex 39 Area, the crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB). The journey is in support of engineering analysis vibration tests on the crawler and MLP. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KSC-03PD-3120

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. In the distance, at left, is Launch Pad 39A. The water on the right of the crawlerway is the Banana River. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KSC-04PD-1063

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1064

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1075

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Water recedes from the Mobile Launcher Platform (MLP) on Launch Pad 39A after the water sound suppression test. Workers and the media (left) were on hand to witness the rare event. This test was conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1062

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1063

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1065

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1075

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- Water recedes from the Mobile Launcher Platform (MLP) on Launch Pad 39A after the water sound suppression test. Workers and the media (left) were on hand to witness the rare event. This test was conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1064

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1062

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-2009-4425

NASA Image and Video Library

2009-08-04

CAPE CANAVERAL, Fla. – Sitting on top of the mobile launcher platform, space shuttle Discovery straddles the flame trench, which channels the flames and smoke exhaust of the shuttle's solid rocket boosters away from the space shuttle during liftoff, on Launch Pad 39A at NASA's Kennedy Space Center in Florida. Traveling from the Vehicle Assembly Building, the shuttle took nearly 12 hours on the journey as technicians stopped several times to clear mud from the crawler's treads and bearings caused by the waterlogged crawlerway. First motion out of the VAB was at 2:07 a.m. EDT Aug. 4. Rollout was delayed approximately 2 hours due to lightning in the area. Discovery was secured, or "hard down" to Launch Pad 39A at 1:50 p.m. EDT. "Hard down" means that the mobile launcher platform, or MLP, is sitting on the pedestals on the pad, and the crawler has been jacked down, thus transferring the weight of the MLP from the crawler to the pad pedestals. Discovery's 13-day flight will deliver a new crew member and 33,000 pounds of equipment to the International Space Station. The equipment includes science and storage racks, a freezer to store research samples, a new sleeping compartment and the COLBERT treadmill. Launch of Discovery on its STS-128 mission is targeted for late August. Photo credit: NASA/Troy Cryder

KSC-00padig052

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- As the early morning sky lights up, Space Shuttle Endeavour inches its way to Launch Pad 39B (on the horizon) via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is atop the Mobile Launcher Platform (MLP). Visible beneath the MLP is the crawler-transporter, which moves on four double-tracked crawlers. Each shoe on the crawler track weighs a ton. Unloaded, the transporter weighs 6 million pounds and moves at 2 mph. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig052

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- As the early morning sky lights up, Space Shuttle Endeavour inches its way to Launch Pad 39B (on the horizon) via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is atop the Mobile Launcher Platform (MLP). Visible beneath the MLP is the crawler-transporter, which moves on four double-tracked crawlers. Each shoe on the crawler track weighs a ton. Unloaded, the transporter weighs 6 million pounds and moves at 2 mph. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-2014-2616

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb to the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2621

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2626

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A, in the background, to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-04pd1066

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. Because of the unusual event, media and workers watch from nearby vantage points on the Fixed Service Structure (left). This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released for launch just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1072

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- From vantage points on the Fixed Service Structure (bottom right and left) on Launch Pad 39A, workers and the media look down upon the Mobile Launcher Platform (MLP) at the start of a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1074

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Water is released onto the Mobile Launcher Platform (MLP) on Launch Pad 39A at the start of a water sound suppression test. Workers and the media (left) are on hand to witness the rare event. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1073

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Water is released onto the Mobile Launcher Platform (MLP) on Launch Pad 39A at the start of a water sound suppression test. Workers and the media (left) are on hand to witness the rare event. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04PD-1076

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Some water remains on the surface of the Mobile Launcher Platform (MLP) on Launch Pad 39A after a water sound suppression test. Workers and the media (left) were on hand to witness the rare event. This test was conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1073

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- Water is released onto the Mobile Launcher Platform (MLP) on Launch Pad 39A at the start of a water sound suppression test. Workers and the media (left) are on hand to witness the rare event. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1071

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- From vantage points on the Fixed Service Structure (left) on Launch Pad 39A, workers and the media look down upon the Mobile Launcher Platform (MLP) waiting for the start of a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1074

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- Water is released onto the Mobile Launcher Platform (MLP) on Launch Pad 39A at the start of a water sound suppression test. Workers and the media (left) are on hand to witness the rare event. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1076

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- Some water remains on the surface of the Mobile Launcher Platform (MLP) on Launch Pad 39A after a water sound suppression test. Workers and the media (left) were on hand to witness the rare event. This test was conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1070

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- From vantage points on the Fixed Service Structure (left) on Launch Pad 39A, workers and the media look down upon the Mobile Launcher Platform (MLP) waiting for the start of a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1072

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- From vantage points on the Fixed Service Structure (bottom right and left) on Launch Pad 39A, workers and the media look down upon the Mobile Launcher Platform (MLP) at the start of a water sound suppression test. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC01pp0565

NASA Image and Video Library

2001-03-22

KENNEDY SPACE CENTER, Fla. -- Viewed from across the turn basin at Launch Complex 39 area, Space Shuttle Endeavour leaves the Vehicle Assembly Building high bay 3 (open door) atop a Mobile Launcher Platform and begins rolling to Launch Pad 39A via a crawler-transporter. The combined height of the Shuttle, MLP and transporter is 235.2 ft. (71.6 m). Once at the pad, routine launch pad validations will commence, verifying all vehicle and facility interfaces. Endeavour is expected to lift off on mission STS-100 on April 19, carrying the Multi-Purpose Logistics Module Raffaello and the Canadian robotic arm, SSRMS, to the International Space Station

KSC01padig173

NASA Image and Video Library

2001-03-22

KENNEDY SPACE CENTER, Fla. -- Viewed from across the turn basin at Launch Complex 39 area, Space Shuttle Endeavour leaves the Vehicle Assembly Building high bay 3 (open door) atop a Mobile Launcher Platform and begins rolling to Launch Pad 39A via a crawler-transporter. The combined height of the Shuttle, MLP and transporter is 235.2 ft. (71.6 m). Once at the pad, routine launch pad validations will commence, verifying all vehicle and facility interfaces. Endeavour is expected to lift off on mission STS-100 on April 19, carrying the Multi-Purpose Logistics Module Raffaello and the Canadian robotic arm, SSRMS, to the International Space Station

STS-106 orbiter Atlantis rolls over to the VAB

NASA Technical Reports Server (NTRS)

2000-01-01

The orbiter Atlantis heads toward the open door of the Vehicle Assembly Building (VAB) on the north side. In the VAB it will be lifted to vertical and placed aboard the mobile launcher platform (MLP) for stacking with the solid rocket boosters and external tank. Atlantis is scheduled to launch Sept. 8 on mission STS-106, the fourth construction flight to the International Space Station, with a crew of seven.

Mobile Launch Platform (MLP) Environmental Assessment

DTIC Science & Technology

2004-06-28

Sometimes these winds are interrupted by cool seasonal storms with southerly winds; dry offshore storms with southeasterly winds, called Santa Ana...winds; coastal eddies during the warm season with southeasterly winds over the inner waters; and alternating land and sea breezes that occur closer to...mean temperature of 14 oC (58 oF). Total annual precipitation averages 21.3 centimeters (8.4 inches). The dry season ranges from May to September and

STS-106 orbiter Atlantis rolls over to the VAB

NASA Technical Reports Server (NTRS)

2000-01-01

Inside the Vehicle Assembly Building (VAB), overhead cranes move above the orbiter Atlantis in order to lift it to vertical. When vertical, the orbiter will be placed aboard the mobile launcher platform (MLP) for stacking with the solid rocket boosters and external tank. Atlantis is scheduled to launch Sept. 8 on mission STS-106, the fourth construction flight to the International Space Station, with a crew of seven.

KSC-02pd0390

NASA Image and Video Library

2002-04-03

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Atlantis is revealed as the Rotating Service Structure rolls back into launch position. The RSS provides protected access to the orbiter for changeout and servicing of payloads at the pad. The structure has access platforms at five levels to provide access to the payload bay. The Shuttle rests on the Mobile Launcher Platform (MLP), which straddles the flame trench below. The flame trench is part of the Flame Deflector System that insulates pad structures from the intense heat of the launch. Above the golden external tank is the vent hood (known as the "beanie cap") at the end of the gaseous oxygen vent arm. Vapors are created as the liquid oxygen in the external tank boil off. The hood vents the gaseous oxygen vapors away from the Space Shuttle vehicle. Mission STS-110 is scheduled to launch April 4 on its 11-day mission to the International Space Station

KSC00pp0637

NASA Image and Video Library

2000-05-18

KENNEDY SPACE CENTER, Fla. -- After rollback of the Rotating Service Structure, Space Shuttle Atlantis can be seen atop the mobile launcher platform (MLP) on Launch Pad 39A. Below the MLP is the flame trench, part of the flame deflector system that insulates pad structures from the intense heat of launch. Made of concrete and refractory brick, the trench is 490 feet long, 48 feet wide and 40 feet high. At the top of the orange external tank can be seen the Gaseous Oxygen Vent Hood, often called the "beanie cap." The hood helps vent gaseous oxygen vapors away from the Space Shuttle. The hood will be raised and retracted two and a half minutes before launch. Abutting the side of Atlantis is the orbiter access arm with the environmental chamber known as the White Room at the end. The White Room provides access to the crew compartment. This will be the third assembly flight to the International Space Station. Liftoff of Space Shuttle Atlantis for the 10-day STS-101 mission is scheduled for about 6:12 a.m. EDT from Launch Pad 39A. Landing is targeted for May 29 at 2:19 a.m. EDT. This is the 98th Shuttle flight and the 21st flight for Shuttle Atlantis

KSC-00pp0637

NASA Image and Video Library

2000-05-18

KENNEDY SPACE CENTER, Fla. -- After rollback of the Rotating Service Structure, Space Shuttle Atlantis can be seen atop the mobile launcher platform (MLP) on Launch Pad 39A. Below the MLP is the flame trench, part of the flame deflector system that insulates pad structures from the intense heat of launch. Made of concrete and refractory brick, the trench is 490 feet long, 48 feet wide and 40 feet high. At the top of the orange external tank can be seen the Gaseous Oxygen Vent Hood, often called the "beanie cap." The hood helps vent gaseous oxygen vapors away from the Space Shuttle. The hood will be raised and retracted two and a half minutes before launch. Abutting the side of Atlantis is the orbiter access arm with the environmental chamber known as the White Room at the end. The White Room provides access to the crew compartment. This will be the third assembly flight to the International Space Station. Liftoff of Space Shuttle Atlantis for the 10-day STS-101 mission is scheduled for about 6:12 a.m. EDT from Launch Pad 39A. Landing is targeted for May 29 at 2:19 a.m. EDT. This is the 98th Shuttle flight and the 21st flight for Shuttle Atlantis

KSC-00pp1622

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1622

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-04pd1067

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are being released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. Because of the unusual event, media and workers watch from nearby vantage points on the Fixed Service Structure (left). This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1069

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are being released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. Because of the unusual event, media and workers watch from nearby vantage points on the Fixed Service Structure (left). This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1068

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- For the fourth time in Space Shuttle Program history, 350,000 gallons of water are being released on a Mobile Launcher Platform (MLP) at Launch Pad 39A during a water sound suppression test. Because of the unusual event, media and workers watch from nearby vantage points on the Fixed Service Structure (left). This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter's three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

Atlantis STS-135 Rollout

NASA Image and Video Library

2011-05-30

Crowds of people are seen watching the rollout of the space shuttle Atlantis in this image made atop of the Mobile Launcher Platform (MLP) that is carrying Atlantis from High Bay 3 in the Vehicle Assembly Building to Launch Pad 39a for its final flight, Tuesday evening, May 31, 2011, at Kennedy Space Center in Cape Canaveral, Fla. The 3.4-mile trek, known as "rollout," will take about seven hours to complete. Atlantis will carry the Raffaello multipurpose logistics module to deliver supplies, logistics and spare parts to the International Space Station. The launch of STS-135 is targeted for July 8. Photo Credit: (NASA/Bill Ingalls)

STS-106 orbiter Atlantis rolls over to the VAB

NASA Technical Reports Server (NTRS)

2000-01-01

The orbiter Atlantis is moved aboard an orbiter transporter from the Orbiter Processing Facility (OPF) bay 3 over to the Vehicle Assembly Building (VAB). In the background (right) are OPF bays 1 and 2. In the VAB it will be lifted to vertical and placed aboard the mobile launcher platform (MLP) for stacking with the solid rocket boosters and external tank. Atlantis is scheduled to launch Sept. 8 on mission STS-106, the fourth construction flight to the International Space Station, with a crew of seven.

STS-106 orbiter Atlantis rolls over to the VAB

NASA Technical Reports Server (NTRS)

2000-01-01

KSC employees accompany the orbiter Atlantis as it is moved aboard an orbiter transporter to the Vehicle Assembly Building (VAB). In the background are OPF bays 1 and 2. In the VAB it will be lifted to vertical and placed aboard the mobile launcher platform (MLP) for stacking with the solid rocket boosters and external tank. Atlantis is scheduled to launch Sept. 8 on mission STS-106, the fourth construction flight to the International Space Station, with a crew of seven.

STS-106 orbiter Atlantis rolls over to the VAB

NASA Technical Reports Server (NTRS)

2000-01-01

Viewed from an upper level in the Vehicle Assembly Building (VAB), the orbiter Atlantis waits in the transfer aisle after its move from the Orbiter Processing Facility. In the VAB it will be lifted to vertical and placed aboard the mobile launcher platform (MLP) for stacking with the solid rocket boosters and external tank. Atlantis is scheduled to launch Sept. 8 on mission STS-106, the fourth construction flight to the International Space Station, with a crew of seven.

ESTIMATION OF THE SPACE SHUTTLE ROLLOUT FORCING FUNCTION

NASA Technical Reports Server (NTRS)

James, George H., III; Carne, Thomas; Elliott, Kenny; Wilson, Bruce

2005-01-01

The Space Shuttle Vehicle is assembled in the Vertical Assembly Building (VAB) at Kennedy Space Flight Center in Florida. The Vehicle is stacked on a Mobile Launch Platform (MLP) that weighs eight million pounds. A Crawler Transporter (CT) then carries the MLP and the stacked vehicle (12 million pounds total weight) to the launch complex located 5 miles away. This operation is performed at 0.9 mph resulting in a 4.5-hour transport. A recent test was performed to monitor the dynamic environment that was produced during rollout. It was found that the rollout is a harmonic-rich dynamic environment that was previously not understood. This paper will describe work that has been performed to estimate the forcing function that is produced in the transportation process. The rollout analysis team has determined that there are two families of harmonics of the drive train, which excite the system as a function of CT speed. There are also excitation sources, which are random or narrow-band in frequency and are not a function of CT speed. This presentation will discuss the application of the Sum of Weighted Accelerations Technique (SWAT) to further refine this understanding by estimating the forces and moments at the center-of-mass.

KSC00pp1624

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour inches its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. To the left and right of the Space Shuttle can be seen both launch pads, 39B and 39A respectively. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1624

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour inches its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. To the left and right of the Space Shuttle can be seen both launch pads, 39B and 39A respectively. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1626

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Viewed from across the turn basin at KSC, Space Shuttle Endeavour inches its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig053

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Viewed across the turn basin from the Press mound, Space Shuttle Endeavour inches its way to Launch Pad 39B (on the horizon) via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

Mobile Launch Platform Vehicle Assembly Building Area (SWMU 056) Hot Spot 3 Bioremediation Interim Measures Work Plan, Kennedy Space Center, Florida

NASA Technical Reports Server (NTRS)

Whitney L. Morrison; Daprato, Rebecca C.

2016-01-01

This Interim Measures Work Plan (IMWP) presents an approach and design for the remediation of chlorinated volatile organic compound (CVOC) groundwater impacts using bioremediation (biostimulation and bioaugmentation) in Hot Spot 3, which is defined by the area where CVOC (trichloroethene [TCE], cis-1,2-dichloroethene [cDCE], and vinyl chloride [VC]) concentrations are greater than 10 times their respective Florida Department of Environmental Protection (FDEP) Natural Attenuation Default Concentration (NADC) [10xNADC] near the western Mobile Launch Platform (MLP) structure. The IM treatment area is the Hot Spot 3 area, which is approximately 0.07 acres and extends from approximately 6 to 22 and 41 to 55 feet below land surface (ft BLS). Within Hot Spot 3, a source zone (SZ; area with TCE concentrations greater than 1% solubility [11,000 micrograms per liter (micrograms/L)]) was delineated and is approximately 0.02 acres and extends from approximately 6 to 16 and 41 to 50 ft BLS.

Replacement for a Flex Hose Coating at the Space Shuttle Launch Pad

NASA Technical Reports Server (NTRS)

Whitten, Mary; Vinje, Rubiela; Curran, Jerome; Meneghelli, Barry; Calle, Luz Marina

2009-01-01

Aerocoat AR-7 is a coating that has been used to protect stainless steel flex hoses at NASA's Kennedy Space Center launch complex and hydraulic lines of the mobile launch platform (MLP). This coating has great corrosion control performance and low temperature application. AR-7 was developed by NASA and produced exclusively for NASA but its production has been discontinued due to its high content of volatile organic compounds (VOC) and significant environmental impact. The purpose of this project was to select and evaluate candidate coatings to find a replacement coating that is more environmentally friendly, with similar properties to AR-7. No coatings were identified that perform the same as AR-7 in all areas. Candidate coatings failed in comparison to AR-7 in salt fog, beachside atmospheric exposure, pencil hardness, Mandrel bend, chemical compatibility, adhesion, and ease of application tests. However, two coatings were selected for further evaluation.

KENNEDY SPACE CENTER, FLA. - As the crawler transporter slowly moves the Mobile Launcher Platform (MLP) out of the Vehicle Assembly Building, the driver of the front control cab can be seen. The MLP is carrying two solid rocket boosters for engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - As the crawler transporter slowly moves the Mobile Launcher Platform (MLP) out of the Vehicle Assembly Building, the driver of the front control cab can be seen. The MLP is carrying two solid rocket boosters for engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

Time-Dependent Simulations of Turbopump Flows

NASA Technical Reports Server (NTRS)

Kiris, Cetin; Kwak, Dochan; Chan, William; Williams, Robert

2002-01-01

Unsteady flow simulations for RLV (Reusable Launch Vehicles) 2nd Generation baseline turbopump for one and half impeller rotations have been completed by using a 34.3 Million grid points model. MLP (Multi-Level Parallelism) shared memory parallelism has been implemented in INS3D, and benchmarked. Code optimization for cash based platforms will be completed by the end of September 2001. Moving boundary capability is obtained by using DCF module. Scripting capability from CAD (computer aided design) geometry to solution has been developed. Data compression is applied to reduce data size in post processing. Fluid/Structure coupling has been initiated.

MLP-1 on Crawler Transporter 2 (CT-2)

NASA Image and Video Library

2017-03-22

NASA's upgraded crawler-transporter 2 (CT-2), carrying mobile launcher platform 1, moves slowly along the crawlerway at the agency's Kennedy Space Center in Florida. The crawler's upgrades and modifications will be monitored and tested under loaded conditions during its travel to the crawlerway Pad A/B split and back to the crawler yard to confirm it is ready to support the load of the mobile launcher carrying the Space Launch System with Orion atop for the first test flight, Exploration Mission 1. The Ground Systems Development and Operations Program at Kennedy is managing upgrades to the crawler.

KSC00pp1625

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour appears to be framed by palms in this view across the turn basin at KSC. Endeavour is inching its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, along the crawlerway in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, along the crawlerway in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

MLP-1 on Crawler Transporter 2 (CT-2)

NASA Image and Video Library

2017-03-22

Ground support technicians walk alongside NASA's upgraded crawler-transporter 2 (CT-2), carrying mobile launcher platform 1, as it slowly travels on the crawlerway at the agency's Kennedy Space Center in Florida. The crawler's upgrades and modifications will be monitored and tested under loaded conditions during its travel to the crawlerway Pad A/B split and back to the crawler yard to confirm it is ready to support the load of the mobile launcher carrying the Space Launch System with Orion atop for the first test flight, Exploration Mission 1. The Ground Systems Development and Operations Program at Kennedy is managing upgrades to the crawler.

MLP-1 on Crawler Transporter 2 (CT-2)

NASA Image and Video Library

2017-03-22

NASA's upgraded crawler-transporter 2 (CT-2), carrying mobile launcher platform 1, moves slowly along the crawlerway toward the Vehicle Assembly Building at the agency's Kennedy Space Center in Florida. The crawler's upgrades and modifications were monitored and tested during a loaded test to the crawlerway Pad A/B split. CT-2 will return to the crawler yard. The crawler is being tested to confirm it is ready to support the load of the mobile launcher carrying the Space Launch System with Orion atop for the first test flight, Exploration Mission 1. The Ground Systems Development and Operations Program at Kennedy is managing upgrades to the crawler.

KENNEDY SPACE CENTER, FLA. - Framed between palm trees, solid rocket boosters loom above the Mobile Launcher Platform (MLP) as the crawler transporter slowly moves it along the crawlerway. The journey is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - Framed between palm trees, solid rocket boosters loom above the Mobile Launcher Platform (MLP) as the crawler transporter slowly moves it along the crawlerway. The journey is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, away from the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter has slowly moved the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter has slowly moved the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter is slowly moving the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter is slowly moving the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - The crawler transporter slowly moves the Mobile Launcher Platform (MLP), carrying a set of twin solid rocket boosters, out of the Vehicle Assembly Building (VAB) in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

A Fully Redundant On-Line Mass Spectrometer System Used to Monitor Cryogenic Fuel Leaks on the Space Shuttle

NASA Technical Reports Server (NTRS)

Griffin, Timothy P.; Naylor, Guy R.; Haskell, William D.; Breznik, Greg S.; Mizell, Carolyn A.; Helms, William R.; Voska, N. (Technical Monitor)

2002-01-01

An on-line gas monitoring system was developed to replace the older systems used to monitor for cryogenic leaks on the Space Shuttles before launch. The system uses a mass spectrometer to monitor multiple locations in the process, which allows the system to monitor all gas constituents of interest in a nearly simultaneous manner. The system is fully redundant and meets all requirements for ground support equipment (GSE). This includes ruggedness to withstand launch on the Mobile Launcher Platform (MLP), ease of operation, and minimal operator intervention. The system can be fully automated so that an operator is notified when an unusual situation or fault is detected. User inputs are through personal computer using mouse and keyboard commands. The graphical user for detecting cryogenic leaks, many other gas constituents could be monitored using the Hazardous Gas Detection System (HGDS) 2000.

KENNEDY SPACE CENTER, FLA. - Carrying a set of twin solid rocket boosters, the crawler transporter slowly moves the Mobile Launcher Platform (MLP) past the NASA-KSC News Center where the U.S. flag flies daily. The journey is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - Carrying a set of twin solid rocket boosters, the crawler transporter slowly moves the Mobile Launcher Platform (MLP) past the NASA-KSC News Center where the U.S. flag flies daily. The journey is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - As the crawler transporter slowly moves the Mobile Launcher Platform (MLP) out of the Vehicle Assembly Building, the two solid rocket boosters on top are framed in the doorway. The move is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-17

KENNEDY SPACE CENTER, FLA. - As the crawler transporter slowly moves the Mobile Launcher Platform (MLP) out of the Vehicle Assembly Building, the two solid rocket boosters on top are framed in the doorway. The move is in support of engineering analysis vibration tests on the crawler and MLP. The crawler is moving at various speeds up to 1 mph in an effort to achieve vibration data gathering goals as it leaves the VAB and then returns. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - Like candles embedded in a sculptured “cake,” the Mobile Launcher Platform (MLP) number 3 with twin solid rocket boosters bolted to it inches along the crawlerway at various speeds up to 1 mph in an effort to achieve vibration data gathering goals. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

NASA Image and Video Library

2003-11-21

KENNEDY SPACE CENTER, FLA. - Like candles embedded in a sculptured “cake,” the Mobile Launcher Platform (MLP) number 3 with twin solid rocket boosters bolted to it inches along the crawlerway at various speeds up to 1 mph in an effort to achieve vibration data gathering goals. The boosters are braced at the top for stability. The primary purpose of these rollout tests is to gather data to develop future maintenance requirements on the transport equipment and the flight hardware. Various parts of the MLP and crawler transporter have been instrumented with vibration data collection equipment.

KENNEDY SPACE CENTER, FLA. - A camera is installed on the aft skirt of a solid rocket booster in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

NASA Image and Video Library

2003-11-06

KENNEDY SPACE CENTER, FLA. - A camera is installed on the aft skirt of a solid rocket booster in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

CATIA V5 Virtual Environment Support for Constellation Ground Operations

NASA Technical Reports Server (NTRS)

Kelley, Andrew

2009-01-01

This summer internship primarily involved using CATIA V5 modeling software to design and model parts to support ground operations for the Constellation program. I learned several new CATIA features, including the Imagine and Shape workbench and the Tubing Design workbench, and presented brief workbench lessons to my co-workers. Most modeling tasks involved visualizing design options for Launch Pad 39B operations, including Mobile Launcher Platform (MLP) access and internal access to the Ares I rocket. Other ground support equipment, including a hydrazine servicing cart, a mobile fuel vapor scrubber, a hypergolic propellant tank cart, and a SCAPE (Self Contained Atmospheric Protective Ensemble) suit, was created to aid in the visualization of pad operations.

KENNEDY SPACE CENTER, FLA. - The camera installed on the aft skirt of a solid rocket booster is seen here, framed by the railing. The installation is in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

NASA Image and Video Library

2003-11-06

KENNEDY SPACE CENTER, FLA. - The camera installed on the aft skirt of a solid rocket booster is seen here, framed by the railing. The installation is in preparation for a vibration test of the Mobile Launcher Platform with SRBs and external tank mounted. The MLP will roll from one bay to another in the Vehicle Assembly Building.

Operational Lessons Learned from the Ares I-X Flight Test

NASA Technical Reports Server (NTRS)

Davis, Stephan R.

2010-01-01

The Ares I-X flight test, launched in 2009, is the first test of the Ares I crew launch vehicle. This development flight test evaluated the flight dynamics, roll control, and separation events, but also provided early insights into logistical, stacking, launch, and recovery operations for Ares I. Operational lessons will be especially important for NASA as the agency makes the transition from the Space Shuttle to the Constellation Program, which is designed to be less labor-intensive. The mission team itself comprised only 700 individuals over the life of the project compared to the thousands involved in Shuttle and Apollo missions; while missions to and beyond low-Earth orbit obviously will require additional personnel, this lean approach will serve as a model for future Constellation missions. To prepare for Ares I-X, vehicle stacking and launch infrastructure had to be modified at Kennedy Space Center's Vehicle Assembly Building (VAB) as well as Launch Complex (LC) 39B. In the VAB, several platforms and other structures designed for the Shuttle s configuration had to be removed to accommodate the in-line, much taller Ares I-X. Vehicle preparation activities resulted in delays, but also in lessons learned for ground operations personnel, including hardware deliveries, cable routing, transferred work and custodial paperwork. Ares I-X also proved to be a resource challenge, as individuals and ground service equipment (GSE) supporting the mission also were required for Shuttle or Atlas V operations at LC 40/41 at Cape Canaveral Air Force Station. At LC 39B, several Shuttle-specific access arms were removed and others were added to accommodate the in-line Ares vehicle. Ground command, control, and communication (GC3) hardware was incorporated into the Mobile Launcher Platform (MLP). The lightning protection system at LC 39B was replaced by a trio of 600-foot-tall towers connected by a catenary wire to account for the much greater height of the vehicle. Like Shuttle, Ares I-X will be stacked on a MLP and rolled out to the pad on a Saturn-era crawler-transporter. While Ares I-X was only held in place by the four hold-down posts on its aft skirt during rollout, a new vehicle stabilization system (VSS) attached to the vertical service structure kept the vehicle from undue swaying prior to launch at the pad, LC 39B. Following the launch, the flight test vehicle first stage was recovered with the aid of new parachutes resized to accommodate the five-segment-long first stage, which had a much greater length and mass than the Shuttle s reusable solid rocket boosters. After splashdown, recovery divers exercised extra care when handling the first stage to ensure that the flight data recorders in the fifth segment simulator were not damaged by exposure to sea water. The data recovered from the Ares I-X flight test will be very valuable in verifying the predicted environments and models used to design the vehicle. Lessons learned from Ares I-X will be shared with the Ares Projects through written and verbal reports and through integration of mission team members into the Project workforce.

Development and Implementation of Environmentally Compatible Solid Film Lubricants

NASA Technical Reports Server (NTRS)

Novak, Howard L.; Hall, Phillip B.

1999-01-01

Multi-body launch vehicles require the use of Solid Film Lubricants (SFLs) to allow for unrestricted relative motion between structural assemblies and components during lift-off and ascent into orbit. The Space Shuttle Solid Rocket Booster (SRB), uses a dual coat, ceramic-bonded high temperature SFL in several locations such as restraint hardware between the SRB aft skirt and the Mobile Launch Platform (MLP), the aft SRB/External Tank (ET) attach struts, and the forward skirt SRB/ET attach ball assembly. Future launch systems may require similar applications of SFLs for attachment and restraint hardware. A family of environmentally compatible non-lead/antimony bearing alternative SFLs have been developed including a compatible repair material. In addition, commercial applications for SFLs on transportation equipment, all types of lubricated fasteners, and energy related equipment allow for wide usage's of these new lubricants. The new SFLs trade named BOOSTERLUBE is a family of single layer thin film (0.001 inch maximum) coatings that are a unique mixture of non-hazardous pigments in a compatible resin system that allows for low temperature curing (450 F). Significant savings in energy and processing time as well as elimination of hazardous material usage and disposal would result from the non-toxic one-step SFL application. Compatible air-dry field repair lubricants will help eliminate disassembly of launch vehicle restraint hardware during critical time sensitive assembly operations.

Aerocoat 7 Replacement Coatings

NASA Technical Reports Server (NTRS)

2008-01-01

Kennedy Space Center has used Aerocoat 7 (AR-7) to protect stainless-steel flex hoses at Launch Complex (LC-39) and hydraulic lines of the Mobile Launcher Platform (MLP) because it provides excellent corrosion protection in low-temperature applications. The Sovereign Company produced AR-7 exclusively for NASA but discontinued production because the coating released high levels of volatile organic compounds (VOCs) and had a significant environmental impact. The purpose of this project was to select and evaluate potential replacement coatings for AR-7 that would be more environmentally sound. The physical and mechanical properties of commercially available coatings were investigated through the Internet. The ideal coating would be fluid enough to penetrate the outer mesh of a stainless-steel flex hose and coat the inner hose, and flexible enough to withstand the movement of the hose, as well as the expansion and contraction of its metal caused by changes in temperature.

A Fully Redundant On-Line Mass Spectrometer System Used to Monitor Cryogenic Fuel Leaks on the Space Shuttle

NASA Technical Reports Server (NTRS)

Griffin, Timothy P.; Naylor, Guy R.; Haskell, William D.; Breznik, Greg S.; Mizell, Carolyn A.; Helms, William R.; Steinrock, T. (Technical Monitor)

2001-01-01

An on-line gas monitoring system was developed to replace the older systems used to monitor for cryogenic leaks on the Space Shuttles before launch. The system uses a mass spectrometer to monitor multiple locations in the process, which allows the system to monitor all gas constituents of interest in a nearly simultaneous manner. The system is fully redundant and meets all requirements for ground support equipment (GSE). This includes ruggedness to withstand launch on the Mobile Launcher Platform (MLP), ease of operation, and minimal operator intervention. The system can be fully automated so that an operator is notified when an unusual situation or fault is detected. User inputs are through personal computer using mouse and keyboard commands. The graphical user interface is very intuitive and easy to operate. The system has successfully supported four launches to date. It is currently being permanently installed as the primary system monitoring the Space Shuttles during ground processing and launch operations. Time and cost savings will be substantial over the current systems when it is fully implemented in the field. Tests were performed to demonstrate the performance of the system. Low limits-of-detection coupled with small drift make the system a major enhancement over the current systems. Though this system is currently optimized for detecting cryogenic leaks, many other gas constituents could be monitored using the Hazardous Gas Detection System (HGDS) 2000.

Space Shuttle Crawler Transporter Sound Attenuation Study

NASA Technical Reports Server (NTRS)

Margasahayam, Ravi N.; MacDonald, Rod; Faszer, Clifford

2004-01-01

The crawler transporter (CT) is the world's largest tracked vehicle known, weighing 6 million pounds with a length of 131 feet and a width of 113 feet. The Kennedy Space Center (KSC) has two CTs that were designed and built for the Apollo program in the 1960's, maintained and retrofitted for use in the Space Shuttle program. As a key element of the Space Shuttle ground systems, the crawler transports the entire 12-million-pound stack comprising the orbiter, the mobile launch platform (MLP), the external tank (ET), and the solid rocket boosters (SRB) from the Vehicle Assembly Building (VAB) to the launch pad. This rollout, constituting a 3.5-5.0-mile journey at a top speed of 0.9 miles-per-hour, requires over 8 hours to reach either Launch Complex 39A or B. This activity is only a prelude to the spectacle of sound and fury of the Space Shuttle launch to orbit in less than 10 minutes and traveling at orbital velocities of Mach 24. This paper summarizes preliminary results from the Crawler Transporter Sound Attenuation Study, encompassing test and engineering analysis of significant sound sources to measure and record full frequency spectrum and intensity of the various noise sources and to analyze the conditions of vibration. Additionally, data such as ventilation criteria, plus operational procedures were considered to provide a comprehensive noise suppression design for implementation. To date, sound attenuation study and results on Crawler 2 have shown significant noise reductions ranging from 5 to 24 dBA.

Posture and activity recognition and energy expenditure estimation in a wearable platform.

PubMed

Sazonov, Edward; Hegde, Nagaraj; Browning, Raymond C; Melanson, Edward L; Sazonova, Nadezhda A

2015-07-01

The use of wearable sensors coupled with the processing power of mobile phones may be an attractive way to provide real-time feedback about physical activity and energy expenditure (EE). Here, we describe the use of a shoe-based wearable sensor system (SmartShoe) with a mobile phone for real-time recognition of various postures/physical activities and the resulting EE. To deal with processing power and memory limitations of the phone, we compare the use of support vector machines (SVM), multinomial logistic discrimination (MLD), and multilayer perceptrons (MLP) for posture and activity classification followed by activity-branched EE estimation. The algorithms were validated using data from 15 subjects who performed up to 15 different activities of daily living during a 4-h stay in a room calorimeter. MLD and MLP demonstrated activity classification accuracy virtually identical to SVM (∼ 95%) while reducing the running time and the memory requirements by a factor of >10 3. Comparison of per-minute EE estimation using activity-branched models resulted in accurate EE prediction (RMSE = 0.78 kcal/min for SVM and MLD activity classification, 0.77 kcal/min for MLP versus RMSE of 0.75 kcal/min for manual annotation). These results suggest that low-power computational algorithms can be successfully used for real-time physical activity monitoring and EE estimation on a wearable platform.

The effect of friction in the hold down post spherical bearings on hold down post loads

NASA Technical Reports Server (NTRS)

Richardson, James A.

1990-01-01

The effect of friction at the connection of the Solid Rocket Booster (SRB) aft skirt and the mobile launch platform (MLP) hold down posts was analyzed. A simplified model of the shuttle response during the Space Shuttle Main Engine (SSME) buildup was constructed. The model included the effect of stick-slip friction for the rotation of the skirt about the spherical bearing. Current finite element models assume the joint is completely frictionless in rotation and therefore no moment is transferred between the skirt and the hold down posts. The model was partially verified against test data and preliminary parameter studies were performed. The parameter studies indicated that the coefficient of friction strongly influenced the moment on the hold down posts. The coefficient of friction had little effect on hold down post vertical loads, however. Further calibration of the model is necessary before the effect of friction on the hold down post horizontal loads can be analyzed.

Results of tests of MTA-2 TPS on the SRB hold-down bolt blast container

NASA Technical Reports Server (NTRS)

Dean, W. G.

1982-01-01

The four solid rocket booster (SRB) hold-down posts are fastened to the mobile launch platform (MLP) with four large nuts. At liftoff the nuts are split with explosive changes to release the SRB/Shuttle. A blast container is placed over the nuts to protect the vehicle from flying debris. The blast container is a reusable part and has to be protected from aerodynamic heating during flight. The thermal protection system (TPS) used to protect these blast containers is cork. Fitting the flat cork sheet to this hemispherical shaped blast container is both time consuming and expensive. Another problem is removing the charred cork and epoxy glue from the blast containers. Replacements of this cork with another TPS material such as MTA-2 was examined. Heating rates along the centerline of the forward facing areas of the blast container were determined. The feasibility of using 1/2 in. MTA-2 on the SRB blast containers for protection from ascent, plume impingement and reentry heating is demonstrated.

Calibrating the Helium Pressurization System for the Space Shuttle Liquid-Hydrogen Tank

NASA Technical Reports Server (NTRS)

2008-01-01

Analysis of the results from the STS-114 tanking tests and subsequent launch called into question existing thermal and mass models of helium pressurization of the liquid hydrogen tank. This hydrogen tank, which makes up the bottom two-thirds of the External Tank, is pressurized prior to launch to avoid cavitation in the Shuttle Main Engine pumps. At about 2 minutes prior to launch, the main vent valve is closed, and pressurized helium flows into the tank ullage space to achieve set point pressure. As the helium gas cools, its pressure drops, calling for additional helium. Subsequent helium flows are provided in short, timed pulses. The number of pulses is taken as a rough leak indicator. An analysis of thermal models by Marshall Space Flight Center showed considerable uncertainty in the pressure-versus-time behavior of the helium ullage space and the ability to predict the number of pulses normally expected. Kennedy Space Center proposed to calibrate the dime-sized orifice, which together with valves, controls the helium flow quantity (Figure 1). Pressure and temperature sensors were installed to provide upstream and downstream measurements necessary to compute flow rate based on the orifice discharge coefficient. An assessment of flow testing with helium indicated an extremely costly use of this critical resource. In order to reduce costs, we proposed removing the orifices from each Mobile Launcher Platform (MLP) and asking Colorado Engineering Experiment Station Inc. (CEESI) to calibrate the flow. CEESI has a high-pressure air flow system with traceable flow meters capable of handling the large flow rates. However, literature research indicated that square-edged orifices of small diameters often exhibit significant hysteresis and nonrepeatability in the vicinity of choked or sonic flow. Fortunately, the MLP orifices behaved relatively well in testing (Figure 2). Using curve fitting of the air-flow data, in conjunction with ASME orifice modeling equations, a method of relating the helium mass flow to measured air flow data was obtained. This analysis showed that the highest uncertainty in flow occurred in the vicinity of the choking pressure ratio, as would be expected. In addition, analysis of typical flow pulses showed that most of the helium flow occurred either well below or well above this uncertain area. The final result is the ability to provide postlaunch estimates of helium mass flows that are within 1.5 percent of the actual value.

MLP: A Parallel Programming Alternative to MPI for New Shared Memory Parallel Systems

NASA Technical Reports Server (NTRS)

Taft, James R.

1999-01-01

Recent developments at the NASA AMES Research Center's NAS Division have demonstrated that the new generation of NUMA based Symmetric Multi-Processing systems (SMPs), such as the Silicon Graphics Origin 2000, can successfully execute legacy vector oriented CFD production codes at sustained rates far exceeding processing rates possible on dedicated 16 CPU Cray C90 systems. This high level of performance is achieved via shared memory based Multi-Level Parallelism (MLP). This programming approach, developed at NAS and outlined below, is distinct from the message passing paradigm of MPI. It offers parallelism at both the fine and coarse grained level, with communication latencies that are approximately 50-100 times lower than typical MPI implementations on the same platform. Such latency reductions offer the promise of performance scaling to very large CPU counts. The method draws on, but is also distinct from, the newly defined OpenMP specification, which uses compiler directives to support a limited subset of multi-level parallel operations. The NAS MLP method is general, and applicable to a large class of NASA CFD codes.

Development of Lead Free Energy Absorber for Space Shuttle Blast Container

NASA Technical Reports Server (NTRS)

Balles, Donald; Ingram, Thomas; Novak, Howard; Schricker, Albert

1998-01-01

The Space Shuttle is connected to the mobile launch platform (MLP) by four aft skirt hold down studs on each solid rocket booster (SRB). Prior to lift-off, the frangible nuts inside the aft skirt blast containers are severed into two nut halves by two pyrotechnic booster cartridges. This action releases the Space Shuttle and allows the hold down studs to eject through the aft skirt bore and then down into the MLP. USBI has been tasked to upgrade the blast container for two specific reasons: (1) To eliminate lead for environmental concerns, and (2) To reduce the chance of nut recontact with the holddown stud. Nut recontact with the stud has been identified as a likely contributor to stud hang-ups. This upgrade will replace the lead liner with a unique open cell aluminum foam material, that has commercial and military uses. The aluminum foam used as an energy absorber is a proven design in many other aerospace/defense applications. Additional benefits of using the open cell, energy absorbent aluminum foam in place of the solid lead liner are: (A) Lead handling/exposure and possible contamination, along with hazardous waste disposal, will be eliminated; (B) Approximately 200 lbs. weight savings will be contributed to each Space Shuttle flight by using aluminum foam instead of lead; (C) The new aluminum liner is designed to catch all shrapnel from frangible nuts, thus virtually eliminating chance of debris exiting the HDP and causing potential damage to the vehicle; and (D) Using the lighter aluminum liner instead of lead, allows for easier assembly and disassembly of blast container elements, which also improves safety, operator handling, and the efficiency of operations.

Development of Lead Free Energy Absorber for Space Shuttle Blast Container

NASA Technical Reports Server (NTRS)

Balles, Donald; Ingram, Thomas; Novak, Howard; Schricker, Albert

1999-01-01

The Space Shuttle is connected to the mobile launch platform (MLP) by four aft skirt hold down studs on each solid rocket booster (SRB). Prior to lift-off, the frangible nuts inside the aft skirt blast containers are severed into two nut halves by two pyrotechnic booster cartridges. This action releases the Space Shuttle and allows the hold down studs to eject through the aft skirt bore and then down into the MLP. USBI has been tasked to upgrade the blast container for two specific reasons: (1) To eliminate lead for environmental concerns, and (2) To reduce the chance of nut recontact with the holddown stud. Nut recontact with the stud has been identified as a likely contributor to stud hang-ups. This upgrade will replace the lead liner with a unique open cell aluminum foam material, that has commercial and military uses. The aluminum foam used as an energy absorber is a proven design in many other aerospace/defense applications. Additional benefits of using the open cell, energy absorbent aluminum foam in place of the solid lead liner are: (1) Lead handling / exposure and possible contamination, along with hazardous waste disposal, will be eliminated; (2) Approximately 200 lbs. weight savings will be contributed to each Space Shuttle flight by using aluminum foam instead of lead; (3) The new aluminum liner is designed to catch all shrapnel from frangible nuts, thus virtually eliminating chance of debris exiting the HDP and causing potential damage to the vehicle; (4) Using the lighter aluminum liner instead of lead, allows for easier assembly and disassembly of blast container elements, which also improves safety, operator handling, and the efficiency of operations.

The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.

PubMed

Clark, Kathleen A; Bland, Jennifer M; Beckerle, Mary C

2007-06-15

Muscle LIM protein (MLP) is a cytoskeletal LIM-only protein expressed in striated muscle. Mutations in human MLP are associated with cardiomyopathy; however, the molecular mechanism by which MLP functions is not established. A Drosophila MLP homolog, mlp84B, displays many of the same features as the vertebrate protein, illustrating the utility of the fly for the study of MLP function. Animals lacking Mlp84B develop into larvae with a morphologically intact musculature, but the mutants arrest during pupation with impaired muscle function. Mlp84B displays muscle-specific expression and is a component of the Z-disc and nucleus. Preventing nuclear retention of Mlp84B does not affect its function, indicating that Mlp84B site of action is likely to be at the Z-disc. Within the Z-disc, Mlp84B is colocalized with the N-terminus of D-titin, a protein crucial for sarcomere organization and stretch mechanics. The mlp84B mutants phenotypically resemble weak D-titin mutants. Furthermore, reducing D-titin activity in the mlp84B background leads to pronounced enhancement of the mlp84B muscle defects and loss of muscle structural integrity. The genetic interactions between mlp84B and D-titin reveal a role for Mlp84B in maintaining muscle structural integrity that was not obvious from analysis of the mlp84B mutants themselves, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.

Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry (Morus alba L.) leaves.

PubMed

Yuan, Qingxia; Xie, Yufeng; Wang, Wei; Yan, Yuhua; Ye, Hong; Jabbar, Saqib; Zeng, Xiaoxiong

2015-09-05

Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry leaves (MLP) were investigated in the present study. The optimal extraction conditions with an extraction yield of 10.0 ± 0.5% for MLP were determined as follows: extraction temperature 92 °C, extraction time 3.5h and ratio (v/w, mL/g) of extraction solvent (water) to raw material 34. Two purified fractions, MLP-3a and MLP-3b with molecular weights of 80.99 and 3.64 kDa, respectively, were obtained from crude MLP by chromatography of DEAE-Cellulose 52 and Sephadex G-100. Fourier transform-infrared spectroscopy revealed that crude MLP, MLP-3a and MLP-3b were acidic polysaccharides. Furthermore, crude MLP and MLP-3a had more complicated monosaccharide compositions, while MLP-3b had a relatively higher content of uronic acid. Crude MLP, MLP-3a and MLP-3b exhibited potent Fe(2+) chelating power and scavenging activities on 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, superoxide and 2,2'-azinobis-(3-ethyl-benzothiazolin-6-sulfonic acid) radicals. The results suggested that MLP could be explored as natural antioxidant. Copyright © 2015 Elsevier Ltd. All rights reserved.

Center Planning and Development: Multi-User Spaceport Initiatives

NASA Technical Reports Server (NTRS)

Kennedy, Christopher John

2015-01-01

The Vehicle Assembly building at NASAs Kennedy Space Center has been used since 1966 to vertically assemble every launch vehicle, since the Apollo Program, launched from Launch Complex 39 (LC-39). After the cancellation of the Constellation Program in 2010 and the retirement of the Space Shuttle Program in 2011, the VAB faced an uncertain future. As the Space Launch System (SLS) gained a foothold as the future of American spaceflight to deep space, NASA was only using a portion of the VABs initial potential. With three high bays connected to the Crawler Way transportation system, the potential exists for up to three rockets to be simultaneously processed for launch. The Kennedy Space Center (KSC) Master plan, supported by the Center Planning and Development (CPD) Directorate, is guiding Kennedy toward a 21st century multi-user spaceport. This concept will maintain Kennedy as the United States premier gateway to space and provide multi-user operations through partnerships with the commercial aerospace industry. Commercial aerospace companies, now tasked with transporting cargo and, in the future, astronauts to the International Space Station (ISS) via the Commercial Resupply Service (CRS) and Commercial Crew Program (CCP), are a rapidly growing industry with increasing capabilities to make launch operations more economical for both private companies and the government. Commercial operations to Low Earth Orbit allow the government to focus on travel to farther destinations through the SLS Program. With LC-39B designated as a multi-use launch pad, companies seeking to use it will require an integration facility to assemble, integrate, and test their launch vehicle. An Announcement for Proposals (AFP) was released in June, beginning the process of finding a non-NASA user for High Bay 2 (HB2) and the Mobile Launcher Platforms (MLPs). An Industry Day, a business meeting and tour for interested companies and organizations, was also arranged to identify and answer any additional questions posed by potential proposers. After amending the AFP and posting additional material for potential users to consider, proposals are being accepted until July 31, at which point they will be evaluated to determine the proposer which best meets the objectives of the government. By identifying VAB HB2 as available and seeking proposals from the commercial sector for VAB HB2 and MLP use, Center Planning and Development is ensuring Kennedy Space Centers relevance in the evolving launch industry of the 21st century.

GRID-Launcher v.1.0.

NASA Astrophysics Data System (ADS)

Deniskina, N.; Brescia, M.; Cavuoti, S.; d'Angelo, G.; Laurino, O.; Longo, G.

GRID-launcher-1.0 was built within the VO-Tech framework, as a software interface between the UK-ASTROGRID and a generic GRID infrastructures in order to allow any ASTROGRID user to launch on the GRID computing intensive tasks from the ASTROGRID Workbench or Desktop. Even though of general application, so far the Grid-Launcher has been tested on a few selected softwares (VONeural-MLP, VONeural-SVM, Sextractor and SWARP) and on the SCOPE-GRID.

Joint High Speed Vessel (JHSV) Follow on Operational Test and Evaluation (FOT and E) Report

DTIC Science & Technology

2015-09-21

Speed Vessel (JHSV) ship class. The events covered in this testing were not performed during the Initial Operational Test and Evaluation ( IOT &E...support boats since launch of these type boats was completed in IOT &E. 1 “Initial Operational Test...and Evaluation ( IOT &E) with Live Fire Test and Evaluation (LFT&E) on Joint High Speed Vessel (JHSV),” DOT&E, July 17, 2014. 2 MLP (CCS) is a heavy

AXONOMETRIC, LAUNCH DOOR AND DOOR CYLINDER, LAUNCH PLATFORM ROLLER GUIDE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AXONOMETRIC, LAUNCH DOOR AND DOOR CYLINDER, LAUNCH PLATFORM ROLLER GUIDE, CRIB SUSPENSION SHOCK STRUT, LAUNCH PLATFORM - Dyess Air Force Base, Atlas F Missle Site S-8, Launch Facility, Approximately 3 miles east of Winters, 500 feet southwest of Highway 1770, center of complex, Winters, Runnels County, TX

Scaling NASA Applications to 1024 CPUs on Origin 3K

NASA Technical Reports Server (NTRS)

Taft, Jim

2002-01-01

The long and highly successful joint SGI-NASA research effort in ever larger SSI systems was to a large degree the result of the successful development of the MLP scalable parallel programming paradigm developed at ARC: 1) MLP scaling in real production codes justified ever larger systems at NAS; 2) MLP scaling on 256p Origin 2000 gave SGl impetus to productize 256p; 3) MLP scaling on 512 gave SGI courage to build 1024p O3K; and 4) History of MLP success resulted in IBM Star Cluster based MLP effort.

Isolation, purification and antioxidant activity of polysaccharides from the leaves of maca (Lepidium Meyenii).

PubMed

Caicai, Kang; Limin, Hao; Liming, Zhang; Zhiqiang, Zheng; Yongwu, Yang

2018-02-01

Two fractions of polysaccharides (MLP-1 and MLP-2) were extracted from the leaves of maca (Lepidium Meyenii Walp.) by water, and purified using DEAE-52 ion exchange resin and sephadex G-200 clumns chromatography. An investigation was carried out for their structural characterization and antioxidant activity in vitro. The results indicated that MLP-1 was mainly composed of ribose, rhamnose, arabinose, xylose, mannose, glucose and galactose, with the molar ratio of 0.12:0.32:1.50:0.32:1.03:1.00:0.93; the MLP-2 was a homopolysaccharide composed of glucose. The molecular weight (Mw) of MLP-1 was 42756Da, and the Mw of MLP-2 was 93541Da. The FT-IR spectra showed the general characteristic absorption peak of maca leaf polysaccharides (MLPs). The evaluation of antioxidant activity revealed that MLP-1 had strong scavenging effects in vitro on hydroxyl, superoxide anion and DPPH radicals, whose EC 50 (mg/mL) was 0.44, 0.21, and 0.82, respectively. Both MLP-1 and MLP-2 presented dose-dependently positive effects on the antioxidant-related parameters. The results suggested that the purified MLP-1 displayed better antioxidant capacities than that of MLP-1, which could be explored as potential antioxidant agents for the complementary medicine or functional foods. Copyright © 2017 Elsevier B.V. All rights reserved.

Wind Tunnel Investigation of Ground Wind Loads for Ares Launch Vehicle

NASA Technical Reports Server (NTRS)

Keller, Donald F.; Ivanco, Thomas G.

2010-01-01

A three year program was conducted at the NASA Langley Research Center (LaRC) Aeroelasticity Branch (AB) and Transonic Dynamics Tunnel (TDT) with the primary objective to acquire scaled steady and dynamic ground-wind loads (GWL) wind-tunnel data for rollout, on-pad stay, and on-pad launch configurations for the Ares I-X Flight Test Vehicle (FTV). The experimental effort was conducted to obtain an understanding of the coupling of aerodynamic and structural characteristics that can result in large sustained wind-induced oscillations (WIO) on such a tall and slender launch vehicle and to generate a unique database for development and evaluation of analytical methods for predicting steady and dynamic GWL, especially those caused by vortex shedding, and resulting in significant WIO. This paper summarizes the wind-tunnel test program that employed two dynamically-aeroelastically scaled GWL models based on the Ares I-X Flight Test Vehicle. The first model tested, the GWL Checkout Model (CM), was a relatively simple model with a secondary objective of restoration and development of processes and methods for design, fabrication, testing, and data analysis of a representative ground wind loads model. In addition, parametric variations in surface roughness, Reynolds number, and protuberances (on/off) were investigated to determine effects on GWL characteristics. The second windtunnel model, the Ares I-X GWL Model, was significantly more complex and representative of the Ares I-X FTV and included the addition of simplified rigid geometrically-scaled models of the Kennedy Space Center (KSC) Mobile Launch Platform (MLP) and Launch Complex 39B primary structures. Steady and dynamic base bending moment as well as model response and steady and unsteady pressure data was acquired during the testing of both models. During wind-tunnel testing of each model, flow conditions (speed and azimuth) where significant WIO occurred, were identified and thoroughly investigated. Scaled data from the Ares I-X GWL model test was used in the determination of worst-case loads for the analysis of Ares I-X FTV design wind conditions. Finally, this paper includes a brief discussion of the limited full-scale GWL data acquired during the rollout and on-pad stay of the Ares I-X FTV that was launched from KSC on October 28, 2009.

Development of Lead Free Energy Absorber for Space Shuttle Blast Container

NASA Technical Reports Server (NTRS)

Ingram, T.; Balles, D.; Schricker, A.; Novak, H.

1998-01-01

The Space Shuttle vehicle (SSV) is connected to the mobile launch platform (MLP) by four aft skirt hold down studs on each solid rocket booster (SRB). Prior to lift-off, the frangible nuts inside the aft skirt blast containers (BC) are severed into two nut halves by two pyrotechnic booster cartridges. This action releases the SSV and allows the hold down studs to eject through the aft skirt bore and then down into the MLP. USBI has been tasked to upgrade the BC for two specific reasons; 1. to eliminate lead for environmental concerns, and 2. to reduce the chance of nut recontact with the holddown stud. Nut recontact with the stud has been identified as a likely contributor to stud hangups. This upgrade will replace the lead liner with an aluminum foam material. The aluminum foam used as a energy absorber is a proven design in many other aerospace/defense applications. Additional benefits of using the open cell, energy absorbent aluminum foam in place of the solid lead liner are: A. Lead handling/ exposure, and possible contamination, along with hazardous waste disposal will be eliminated; B. Approximately 200 lbs. weight savings will be contributed to each Space Shuttle flight by using aluminum foam over lead; C. The new aluminum liner is designed to catch all shrapnel from frangible nuts thus virtually eliminating chance of foreign object debris (FOD) exiting the HDP, and causing potential damage to the vehicle; D. Potential of using the lighter aluminum liner over lead, allows for easier assembly and disassembly of blast container elements, also allowing for improvements in safety, operator handling, and efficiency of operations. Six BC firing tests will be required to determine if the new liner material will perform in a way to decrease the chance of stud hangups and enhance the ability of the BC to retain blast debris. Testing will be performed at the Kennedy Space Center (KSC) facility known as the Launch Equipment Test Facility (LETF), and will simulate the SRB hold- down post, with actual BC hardware and pyrotechnics assembled, and then test fired. Initial testing was performed in 1997 using a frangible nut in a static drop test over lead and aluminum foam sheet materials. The aluminum foam showed a dramatic improvement of energy absorption over the lead liner material. Proof-of-Principle testing at the KSC-LETF commenced in May, 1998, and is expected to be completed by June, 1998.

The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids

PubMed Central

Morelle, Christelle; Sterkers, Yvon; Crobu, Lucien; MBang-Benet, Diane-Ethna; Kuk, Nada; Portalès, Pierre; Bastien, Patrick; Pagès, Michel; Lachaud, Laurence

2015-01-01

Nucleoporins are evolutionary conserved proteins mainly involved in the constitution of the nuclear pores and trafficking between the nucleus and cytoplasm, but are also increasingly viewed as main actors in chromatin dynamics and intra-nuclear mitotic events. Here, we determined the cellular localization of the nucleoporin Mlp2 in the ‘divergent’ eukaryotes Leishmania major and Trypanosoma brucei. In both protozoa, Mlp2 displayed an atypical localization for a nucleoporin, essentially intranuclear, and preferentially in the periphery of the nucleolus during interphase; moreover, it relocated at the mitotic spindle poles during mitosis. In T. brucei, where most centromeres have been identified, TbMlp2 was found adjacent to the centromeric sequences, as well as to a recently described unconventional kinetochore protein, in the periphery of the nucleolus, during interphase and from the end of anaphase onwards. TbMlp2 and the centromeres/kinetochores exhibited a differential migration towards the poles during mitosis. RNAi knockdown of TbMlp2 disrupted the mitotic distribution of chromosomes, leading to a surprisingly well-tolerated aneuploidy. In addition, diploidy was restored in a complementation assay where LmMlp2, the orthologue of TbMlp2 in Leishmania, was expressed in TbMlp2-RNAi-knockdown parasites. Taken together, our results demonstrate that Mlp2 is involved in the distribution of chromosomes during mitosis in trypanosomatids. PMID:25690889

Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking.

PubMed

Clark, Kathleen A; Kadrmas, Julie L

2013-06-01

Stabilization of tissue architecture during development and growth is essential to maintain structural integrity. Because of its contractile nature, muscle is especially susceptible to physiological stresses, and has multiple mechanisms to maintain structural integrity. The Drosophila melanogaster Muscle LIM Protein (MLP), Mlp84B, participates in muscle maintenance, yet its precise mechanism of action is still controversial. Through a candidate approach, we identified α-actinin as a protein that functions with Mlp84B to ensure muscle integrity. α-actinin RNAi animals die primarily as pupae, and Mlp84B RNAi animals are adult viable. RNAi knockdown of Mlp84B and α-actinin together produces synergistic early larval lethality and destabilization of Z-line structures. We recapitulated these phenotypes using combinations of traditional loss-of-function alleles and single-gene RNAi. We observe that Mlp84B induces the formation of actin loops in muscle cell nuclei in the absence of nuclear α-actinin, suggesting Mlp84B has intrinsic actin cross-linking activity, which may complement α-actinin cross-linking activity at sites of actin filament anchorage. These results reveal a molecular mechanism for MLP stabilization of muscle and implicate reduced actin crosslinking as the primary destabilizing defect in MLP-associated cardiomyopathies. Our data support a model in which α-actinin and Mlp84B have important and overlapping functions at sites of actin filament anchorage to preserve muscle structure and function. Copyright © 2013 Wiley Periodicals, Inc.

A new yeast gene with a myosin-like heptad repeat structure.

PubMed

Kölling, R; Nguyen, T; Chen, E Y; Botstein, D

1993-03-01

We isolated a gene encoding a 218 kDa myosin-like protein from Saccharomyces cerevisiae using a monoclonal antibody directed against human platelet myosin as a probe. The protein sequence encoded by the MLP1 gene (for myosin-like protein) contains extensive stretches of a heptad-repeat pattern suggesting that the protein can form coiled coils typical of myosins. Immunolocalization experiments using affinity-purified antibodies raised against a TrpE-MLP1 fusion protein showed a dot-like structure adjacent to the nucleus in yeast cells bearing the MLP1 gene on a multicopy plasmid. In mouse epithelial cells the yeast anti-MLP1 antibodies stained the nucleus. Mutants bearing disruptions of the MLP1 gene were viable, but more sensitive to ultraviolet light than wild-type strains, suggesting an involvement of MLP1 in DNA repair. The MLP1 gene was mapped to chromosome 11, 25 cM from met1.

Mobile Landing Platform with Core Capability Set (MLP w/CCS): Combined Initial Operational Test and Evaluation and Live Fire Test and Evaluation Report

DTIC Science & Technology

2015-07-01

annex.   iii Self-defense testing was limited to structural test firing from each machine gun mount and an ammunition resupply drill. Robust self...provided in the classified annex. Self-   8 defense testing was limited to structural test firing from each machine gun mount and a single...Caliber Machine Gun Mount Structural Test Fire November 2014 San Diego, Offshore Ship Weapons Range Operating Independently       9 Section Three

The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids.

PubMed

Morelle, Christelle; Sterkers, Yvon; Crobu, Lucien; MBang-Benet, Diane-Ethna; Kuk, Nada; Portalès, Pierre; Bastien, Patrick; Pagès, Michel; Lachaud, Laurence

2015-04-30

Nucleoporins are evolutionary conserved proteins mainly involved in the constitution of the nuclear pores and trafficking between the nucleus and cytoplasm, but are also increasingly viewed as main actors in chromatin dynamics and intra-nuclear mitotic events. Here, we determined the cellular localization of the nucleoporin Mlp2 in the 'divergent' eukaryotes Leishmania major and Trypanosoma brucei. In both protozoa, Mlp2 displayed an atypical localization for a nucleoporin, essentially intranuclear, and preferentially in the periphery of the nucleolus during interphase; moreover, it relocated at the mitotic spindle poles during mitosis. In T. brucei, where most centromeres have been identified, TbMlp2 was found adjacent to the centromeric sequences, as well as to a recently described unconventional kinetochore protein, in the periphery of the nucleolus, during interphase and from the end of anaphase onwards. TbMlp2 and the centromeres/kinetochores exhibited a differential migration towards the poles during mitosis. RNAi knockdown of TbMlp2 disrupted the mitotic distribution of chromosomes, leading to a surprisingly well-tolerated aneuploidy. In addition, diploidy was restored in a complementation assay where LmMlp2, the orthologue of TbMlp2 in Leishmania, was expressed in TbMlp2-RNAi-knockdown parasites. Taken together, our results demonstrate that Mlp2 is involved in the distribution of chromosomes during mitosis in trypanosomatids. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Pan evaporation prediction using a hybrid multilayer perceptron-firefly algorithm (MLP-FFA) model: case study in North Iran

NASA Astrophysics Data System (ADS)

Ghorbani, M. A.; Deo, Ravinesh C.; Yaseen, Zaher Mundher; H. Kashani, Mahsa; Mohammadi, Babak

2017-08-01

An accurate computational approach for the prediction of pan evaporation over daily time horizons is a useful decisive tool in sustainable agriculture and hydrological applications, particularly in designing the rural water resource systems, water use allocations, utilization and demand assessments, and the management of irrigation systems. In this study, a hybrid predictive model (Multilayer Perceptron-Firefly Algorithm (MLP-FFA)) based on the FFA optimizer that is embedded within the MLP technique is developed and evaluated for its suitability for the prediction of daily pan evaporation. To develop the hybrid MLP-FFA model, the pan evaporation data measured between 2012 and 2014 for two major meteorological stations (Talesh and Manjil) located at Northern Iran are employed to train and test the predictive model. The ability of the hybrid MLP-FFA model is compared with the traditional MLP and support vector machine (SVM) models. The results are evaluated using five performance criteria metrics: root mean square error (RMSE), mean absolute error (MAE), Nash-Sutcliffe efficiency (NS), and the Willmott's Index (WI). Taylor diagrams are also used to examine the similarity between the observed and predicted pan evaporation data in the test period. Results show that an optimal MLP-FFA model outperforms the MLP and SVM model for both tested stations. For Talesh, a value of WI = 0.926, NS = 0.791, and RMSE = 1.007 mm day-1 is obtained using MLP-FFA model, compared with 0.912, 0.713, and 1.181 mm day-1 (MLP) and 0.916, 0.726, and 1.153 mm day-1 (SVM), whereas for Manjil, a value of WI = 0.976, NS = 0.922, and 1.406 mm day-1 is attained that contrasts 0.972, 0.901, and 1.583 mm day-1 (MLP) and 0.971, 0.893, and 1.646 mm day-1 (SVM). The results demonstrate the importance of the Firefly Algorithm applied to improve the performance of the MLP-FFA model, as verified through its better predictive performance compared to the MLP and SVM model.

Performance and Application of Parallel OVERFLOW Codes on Distributed and Shared Memory Platforms

NASA Technical Reports Server (NTRS)

Djomehri, M. Jahed; Rizk, Yehia M.

1999-01-01

The presentation discusses recent studies on the performance of the two parallel versions of the aerodynamics CFD code, OVERFLOW_MPI and _MLP. Developed at NASA Ames, the serial version, OVERFLOW, is a multidimensional Navier-Stokes flow solver based on overset (Chimera) grid technology. The code has recently been parallelized in two ways. One is based on the explicit message-passing interface (MPI) across processors and uses the _MPI communication package. This approach is primarily suited for distributed memory systems and workstation clusters. The second, termed the multi-level parallel (MLP) method, is simple and uses shared memory for all communications. The _MLP code is suitable on distributed-shared memory systems. For both methods, the message passing takes place across the processors or processes at the advancement of each time step. This procedure is, in effect, the Chimera boundary conditions update, which is done in an explicit "Jacobi" style. In contrast, the update in the serial code is done in more of the "Gauss-Sidel" fashion. The programming efforts for the _MPI code is more complicated than for the _MLP code; the former requires modification of the outer and some inner shells of the serial code, whereas the latter focuses only on the outer shell of the code. The _MPI version offers a great deal of flexibility in distributing grid zones across a specified number of processors in order to achieve load balancing. The approach is capable of partitioning zones across multiple processors or sending each zone and/or cluster of several zones into a single processor. The message passing across the processors consists of Chimera boundary and/or an overlap of "halo" boundary points for each partitioned zone. The MLP version is a new coarse-grain parallel concept at the zonal and intra-zonal levels. A grouping strategy is used to distribute zones into several groups forming sub-processes which will run in parallel. The total volume of grid points in each group are approximately balanced. A proper number of threads are initially allocated to each group, and in subsequent iterations during the run-time, the number of threads are adjusted to achieve load balancing across the processes. Each process exploits the multitasking directives already established in Overflow.

KSC-04PD-1077

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- A crimson and gold sunrise over the Central Florida coast begins illuminating Launch Pad 39A, where a water sound suppression test is to take place. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiters three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

KSC-04pd1077

NASA Image and Video Library

2004-05-07

KENNEDY SPACE CENTER, FLA. -- A crimson and gold sunrise over the Central Florida coast begins illuminating Launch Pad 39A, where a water sound suppression test is to take place. This test is being conducted following the replacement of the six main system valves, which had been in place since the beginning of the Shuttle Program and had reached the end of their service life. Also, the hydraulic portion of the valve actuators has been redesigned and simplified to reduce maintenance costs. The sound suppression water system is installed on the launch pads to protect the orbiter and its payloads from damage by acoustical energy reflected from the MLP during launch. The system includes an elevated water tank with a capacity of 300,000 gallons. The tank is 290 feet high and stands on the northeast side of the Pad. The water is released just before the ignition of the orbiter’s three main engines and twin solid rocket boosters, and flows through parallel 7-foot-diameter pipes to the Pad area.

MLP Tools: a PyMOL plugin for using the molecular lipophilicity potential in computer-aided drug design

NASA Astrophysics Data System (ADS)

Oberhauser, Nils; Nurisso, Alessandra; Carrupt, Pierre-Alain

2014-05-01

The molecular lipophilicity potential (MLP) is a well-established method to calculate and visualize lipophilicity on molecules. We are here introducing a new computational tool named MLP Tools, written in the programming language Python, and conceived as a free plugin for the popular open source molecular viewer PyMOL. The plugin is divided into several sub-programs which allow the visualization of the MLP on molecular surfaces, as well as in three-dimensional space in order to analyze lipophilic properties of binding pockets. The sub-program Log MLP also implements the virtual log P which allows the prediction of the octanol/water partition coefficients on multiple three-dimensional conformations of the same molecule. An implementation on the recently introduced MLP GOLD procedure, improving the GOLD docking performance in hydrophobic pockets, is also part of the plugin. In this article, all functions of the MLP Tools will be described through a few chosen examples.

Popular NREL-Developed Transportation Mobile App Launches on Android

Science.gov Websites

Platform | News | NREL Popular NREL-Developed Transportation Mobile App Launches on Android Platform Popular NREL-Developed Transportation Mobile App Launches on Android Platform May 23, 2017 More . Department of Energy's (DOE) National Renewable Energy Laboratory developed the new mobile application for

Throttleable GOX/ABS launch assist hybrid rocket motor for small scale air launch platform

NASA Astrophysics Data System (ADS)

Spurrier, Zachary S.

Aircraft-based space-launch platforms allow operational flexibility and offer the potential for significant propellant savings for small-to-medium orbital payloads. The NASA Armstrong Flight Research Center's Towed Glider Air-Launch System (TGALS) is a small-scale flight research project investigating the feasibility for a remotely-piloted, towed, glider system to act as a versatile air launch platform for nano-scale satellites. Removing the crew from the launch vehicle means that the system does not have to be human rated, and offers a potential for considerable cost savings. Utah State University is developing a small throttled launch-assist system for the TGALS platform. This "stage zero" design allows the TGALS platform to achieve the required flight path angle for the launch point, a condition that the TGALS cannot achieve without external propulsion. Throttling is required in order to achieve and sustain the proper launch attitude without structurally overloading the airframe. The hybrid rocket system employs gaseous-oxygen and acrylonitrile butadiene styrene (ABS) as propellants. This thesis summarizes the development and testing campaign, and presents results from the clean-sheet design through ground-based static fire testing. Development of the closed-loop throttle control system is presented.

Molasses melanoidin promotes copper uptake for radish sprouts: the potential for an accelerator of phytoextraction.

PubMed

Hatano, Ken-Ichi; Kanazawa, Kazuki; Tomura, Hiroki; Yamatsu, Takeshi; Tsunoda, Kin-Ichi; Kubota, Kenji

2016-09-01

Phytoextraction has been proposed as an alternative remediation technology for heavy metal contamination, and it is well known that chelators may alter the toxicity of heavy metals and the bioavailability in plants. Our previous work demonstrated that an adsorbent-column chromatography can effectively separate melanoidin-like product (MLP) from sugarcane molasses. The aim of this study was to examine the chelating property of MLP and to evaluate the facilitatory influence on the phytoextraction efficiency of Japanese radish. The result showed that MLP binds to all the metal ions examined and the binding capacity of MLP toward Cu(2+) seems to be the highest among them. The metal detoxification by MLP followed the order of Pb(2+) > Zn(2+) > Ni(2+) > Cu(2+) > Fe(2+) > Cd(2+) > Co(2+). Furthermore, in the phytoextraction experiment using copper sulfate, the application of MLP accelerated the detoxification of copper and the bioavailability in radish sprouts. Thus, these results suggest that MLP possesses the potential for an accelerator of phytoextraction in the copper-contaminated media.

River flow simulation using a multilayer perceptron-firefly algorithm model

NASA Astrophysics Data System (ADS)

Darbandi, Sabereh; Pourhosseini, Fatemeh Akhoni

2018-06-01

River flow estimation using records of past time series is importance in water resources engineering and management and is required in hydrologic studies. In the past two decades, the approaches based on the artificial neural networks (ANN) were developed. River flow modeling is a non-linear process and highly affected by the inputs to the modeling. In this study, the best input combination of the models was identified using the Gamma test then MLP-ANN and hybrid multilayer perceptron (MLP-FFA) is used to forecast monthly river flow for a set of time intervals using observed data. The measurements from three gauge at Ajichay watershed, East Azerbaijani, were used to train and test the models approach for the period from January 2004 to July 2016. Calibration and validation were performed within the same period for MLP-ANN and MLP-FFA models after the preparation of the required data. Statistics, the root mean square error and determination coefficient, are used to verify outputs from MLP-ANN to MLP-FFA models. The results show that MLP-FFA model is satisfactory for monthly river flow simulation in study area.

A hybrid MLP-CNN classifier for very fine resolution remotely sensed image classification

NASA Astrophysics Data System (ADS)

Zhang, Ce; Pan, Xin; Li, Huapeng; Gardiner, Andy; Sargent, Isabel; Hare, Jonathon; Atkinson, Peter M.

2018-06-01

The contextual-based convolutional neural network (CNN) with deep architecture and pixel-based multilayer perceptron (MLP) with shallow structure are well-recognized neural network algorithms, representing the state-of-the-art deep learning method and the classical non-parametric machine learning approach, respectively. The two algorithms, which have very different behaviours, were integrated in a concise and effective way using a rule-based decision fusion approach for the classification of very fine spatial resolution (VFSR) remotely sensed imagery. The decision fusion rules, designed primarily based on the classification confidence of the CNN, reflect the generally complementary patterns of the individual classifiers. In consequence, the proposed ensemble classifier MLP-CNN harvests the complementary results acquired from the CNN based on deep spatial feature representation and from the MLP based on spectral discrimination. Meanwhile, limitations of the CNN due to the adoption of convolutional filters such as the uncertainty in object boundary partition and loss of useful fine spatial resolution detail were compensated. The effectiveness of the ensemble MLP-CNN classifier was tested in both urban and rural areas using aerial photography together with an additional satellite sensor dataset. The MLP-CNN classifier achieved promising performance, consistently outperforming the pixel-based MLP, spectral and textural-based MLP, and the contextual-based CNN in terms of classification accuracy. This research paves the way to effectively address the complicated problem of VFSR image classification.

Monotreme Lactation Protein Is Highly Expressed in Monotreme Milk and Provides Antimicrobial Protection

PubMed Central

Enjapoori, Ashwantha Kumar; Grant, Tom R.; Nicol, Stewart C.; Lefèvre, Christophe M.; Nicholas, Kevin R.; Sharp, Julie A.

2014-01-01

Monotremes (platypus and echidna) are the descendants of the oldest ancestor of all extant mammals distinguished from other mammals by mode of reproduction. Monotremes lay eggs following a short gestation period and after an even briefer incubation period, altricial hatchlings are nourished over a long lactation period with milk secreted by nipple-less mammary patches located on the female’s abdomen. Milk is the sole source of nutrition and immune protection for the developing young until weaning. Using transcriptome and mass spectrometry analysis of milk cells and milk proteins, respectively, a novel Monotreme Lactation Protein (MLP) was identified as a major secreted protein in milk. We show that platypus and short-beaked echidna MLP genes show significant homology and are unique to monotremes. The MLP transcript was shown to be expressed in a variety of tissues; however, highest expression was observed in milk cells and was expressed constitutively from early to late lactation. Analysis of recombinant MLP showed that it is an N-linked glycosylated protein and biophysical studies predicted that MLP is an amphipathic, α-helical protein, a typical feature of antimicrobial proteins. Functional analysis revealed MLP antibacterial activity against both opportunistic pathogenic Staphylococcus aureus and commensal Enterococcus faecalis bacteria but showed no effect on Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Salmonella enterica. Our data suggest that MLP is an evolutionarily ancient component of milk-mediated innate immunity absent in other mammals. We propose that MLP evolved specifically in the monotreme lineage supporting the evolution of lactation in these species to provide bacterial protection, at a time when mammals lacked nipples. PMID:25245409

Embedded feature ranking for ensemble MLP classifiers.

PubMed

Windeatt, Terry; Duangsoithong, Rakkrit; Smith, Raymond

2011-06-01

A feature ranking scheme for multilayer perceptron (MLP) ensembles is proposed, along with a stopping criterion based upon the out-of-bootstrap estimate. To solve multi-class problems feature ranking is combined with modified error-correcting output coding. Experimental results on benchmark data demonstrate the versatility of the MLP base classifier in removing irrelevant features.

Development of a Hypoxic Radiosensitizer-Prodrug Liposome Delivery DNA Repair Inhibitor Dbait Combination with Radiotherapy for Glioma Therapy.

PubMed

Liu, Hongmei; Cai, Yifan; Zhang, Yafei; Xie, Yandong; Qiu, Hui; Hua, Lei; Liu, Xuejiao; Li, Yuling; Lu, Jun; Zhang, Longzhen; Yu, Rutong

2017-06-01

Gliomas are highly radioresistant tumors, mainly due to hypoxia in the core region of the gliomas and efficient DNA double-strand break repair. However, the design of a radiosensitizer incorporating the two above mechanisms is difficult and has rarely been reported. Thus, this study develops a hypoxic radiosensitizer-prodrug liposome (MLP) to deliver the DNA repair inhibitor Dbait (MLP/Dbait) to achieve the simultaneous entry of radiosensitizers with two different mechanisms into the glioma. MLP/Dbait effectively sensitizes glioma cells to X-ray radiotherapy (RT). Histological and microscopic examinations of dissected brain tissue confirm that MLP effectively delivers Dbait into the glioma. Furthermore, the combination of MLP/Dbait with RT significantly inhibits growth of the glioma, as assessed by in vivo bioluminescence imaging. These findings suggest that MLP is a promising candidate as a Dbait delivery system to enhance the effect of RT on glioma, owing to the synergistic effects of the two different radiosensitizers. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane.

PubMed

Alli, Abdel A; Bao, Hui-Fang; Liu, Bing-Chen; Yu, Ling; Aldrugh, Summer; Montgomery, Darrice S; Ma, He-Ping; Eaton, Douglas C

2015-09-01

Phosphatidylinositol bisphosphate (PIP2) regulates epithelial sodium channel (ENaC) open probability. In turn, myristoylated alanine-rich C kinase substrate (MARCKS) protein or MARCKS-like protein 1 (MLP-1) at the plasma membrane regulates the delivery of PIP2 to ENaC. MARCKS and MLP-1 are regulated by changes in cytosolic calcium; increasing calcium promotes dissociation of MARCKS from the membrane, but the calcium-regulatory mechanisms are unclear. However, it is known that increased intracellular calcium can activate calmodulin and we show that inhibition of calmodulin with calmidazolium increases ENaC activity presumably by regulating MARCKS and MLP-1. Activated calmodulin can regulate MARCKS and MLP-1 in two ways. Calmodulin can bind to the effector domain of MARCKS or MLP-1, inactivating both proteins by causing their dissociation from the membrane. Mutations in MARCKS that prevent calmodulin association prevent dissociation of MARCKS from the membrane. Calmodulin also activates CaM kinase II (CaMKII). An inhibitor of CaMKII (KN93) increases ENaC activity, MARCKS association with ENaC, and promotes MARCKS movement to a membrane fraction. CaMKII phosphorylates filamin. Filamin is an essential component of the cytoskeleton and promotes association of ENaC, MARCKS, and MLP-1. Disruption of the cytoskeleton with cytochalasin E reduces ENaC activity. CaMKII phosphorylation of filamin disrupts the cytoskeleton and the association of MARCKS, MLP-1, and ENaC, thereby reducing ENaC open probability. Taken together, these findings suggest calmodulin and CaMKII modulate ENaC activity by destabilizing the association between the actin cytoskeleton, ENaC, and MARCKS, or MLP-1 at the apical membrane. Copyright © 2015 the American Physiological Society.

PONS2train: tool for testing the MLP architecture and local traning methods for runoff forecast

NASA Astrophysics Data System (ADS)

Maca, P.; Pavlasek, J.; Pech, P.

2012-04-01

The purpose of presented poster is to introduce the PONS2train developed for runoff prediction via multilayer perceptron - MLP. The software application enables the implementation of 12 different MLP's transfer functions, comparison of 9 local training algorithms and finally the evaluation the MLP performance via 17 selected model evaluation metrics. The PONS2train software is written in C++ programing language. Its implementation consists of 4 classes. The NEURAL_NET and NEURON classes implement the MLP, the CRITERIA class estimates model evaluation metrics and for model performance evaluation via testing and validation datasets. The DATA_PATTERN class prepares the validation, testing and calibration datasets. The software application uses the LAPACK, BLAS and ARMADILLO C++ linear algebra libraries. The PONS2train implements the first order local optimization algorithms: standard on-line and batch back-propagation with learning rate combined with momentum and its variants with the regularization term, Rprop and standard batch back-propagation with variable momentum and learning rate. The second order local training algorithms represents: the Levenberg-Marquardt algorithm with and without regularization and four variants of scaled conjugate gradients. The other important PONS2train features are: the multi-run, the weight saturation control, early stopping of trainings, and the MLP weights analysis. The weights initialization is done via two different methods: random sampling from uniform distribution on open interval or Nguyen Widrow method. The data patterns can be transformed via linear and nonlinear transformation. The runoff forecast case study focuses on PONS2train implementation and shows the different aspects of the MLP training, the MLP architecture estimation, the neural network weights analysis and model uncertainty estimation.

46 CFR 199.145 - Marine evacuation system launching arrangements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

46 CFR 199.145 - Marine evacuation system launching arrangements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

46 CFR 199.145 - Marine evacuation system launching arrangements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

46 CFR 199.145 - Marine evacuation system launching arrangements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

46 CFR 199.145 - Marine evacuation system launching arrangements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils.

PubMed

Liao, Hsiang-Ruei; Chen, Ih-Sheng; Liu, Fu-Chao; Lin, Shinn-Zhi; Tseng, Ching-Ping

2018-06-15

This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst and cathepsin G in human neutrophils. Signaling pathways regulated by RIR-2 which modulated fMLP-induced respiratory burst were evaluated by an interaction between β subunit of G-protein (Gβ) with downstream signaling induced by fMLP and by immunoblotting analysis of the downstream targets of Gβ-protein. RIR-2 inhibited fMLP-induced superoxide anion production (IC 50 :2.57 ± 0.22 μM), cathepsin G release (IC 50 :18.72 ± 3.76 μM) and migration in a concentration dependent manner. RIR-2 specifically suppresses fMLP-induced Src family kinases phosphorylation by inhibiting the interaction between Gβ-protein with Src kinases without inhibiting Src kinases activities, therefore, RIR-2 attenuated the downstream targets of Src kinase, such as phosphorylation of Raf/ERK, AKT, P38, PLCγ2, PKC and translocation Tec, p47 ph ° x and P40 ph ° x from the cytosol to the inner leaflet of the plasma membrane. Furthermore, RIR-2 attenuated fMLP-induced intracellular calcium mobilization by inhibiting the interaction between Gβ-protein with PLCβ2. RIR-2 was not a competitive or allosteric antagonist of fMLP. On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47 ph ° x and P40 ph ° x remained unaffected. RIR-2 specifically modulates fMLP-mediated neutrophil superoxide anion production and cathepsin G release by inhibiting the interaction between Gβ-protein with downstream signaling which subsequently interferes with the activation of intracellular calcium, PLCγ2, AKT, p38, PKC, ERK, p47 ph ° x and p40 phox . Copyright © 2018 Elsevier B.V. All rights reserved.

A unique mitigator sequence determines the species specificity of the major late promoter in adenovirus type 12 DNA.

PubMed Central

Zock, C; Iselt, A; Doerfler, W

1993-01-01

Human adenovirus type 12 (Ad12) cannot replicate in hamster cells, whereas human cells are permissive for Ad12. Ad12 DNA replication and late-gene and virus-associated RNA expression are blocked in hamster cells. Early Ad12 genes are transcribed, and the viral DNA can be integrated into the host genome. Ad12 DNA replication and late-gene transcription can be complemented in hamster cells by E1 functions of Ad2 or Ad5, for which hamster cells are fully permissive (for a review, see W. Doerfler, Adv. Virus Res. 39:89-128, 1991). We have previously demonstrated that a 33-nucleotide mitigator sequence, which is located in the downstream region of the major late promoter (MLP) of Ad12 DNA, is responsible for the inactivity of the Ad12 MLP in hamster cells (C. Zock and W. Doerfler, EMBO J. 9:1615-1623, 1990). A similar negative regulator has not been found in the MLP of Ad2 DNA. We have now studied the mechanism of action of this mitigator element. The results of nuclear run-on experiments document the absence of MLP transcripts in the nuclei of Ad12-infected BHK21 hamster cells. Surprisingly, the mitigator element cannot elicit its function in in vitro transcription experiments with nuclear extracts from both hamster BHK21 and human HeLa cells. Intact nuclear topology and/or tightly bound nuclear elements that cannot be eluted in nuclear extracts are somehow required for recognition of the Ad12 mitigator. Electrophoretic mobility shift assays have not revealed significant differences in the binding of proteins from human HeLa or hamster BHK21 cells to the mitigator sequence in the MLP of Ad12 DNA or to the corresponding sequence in Ad2 DNA. We have converted the sequence of the mitigator in the MLP of Ad12 DNA to the equivalent sequence in the MLP of Ad2 DNA by site-directed mutagenesis. This construct was not active in hamster cells. When the Ad12 mitigator, on the other hand, was inserted into the Ad2 MLP, the latter's function in hamster cells was not compromised. Deletions in the 5' upstream region of the Ad12 MLP have provided evidence for the existence of additional sequences that codetermine the deficiency of the Ad12 MLP in hamster cells. The amphifunctional YY1 protein from HeLa cells can bind specifically to the mitigator and to upstream elements of the MLP of Ad12 DNA.(ABSTRACT TRUNCATED AT 400 WORDS) Images PMID:8419643

Molasses melanoidin-like products enhance phytoextraction of lead through three Brassica species.

PubMed

Hatano, Ken-Ichi; Yamatsu, Takeshi

2018-05-12

Previously, it has been suggested that melanoidin-like products (MLP) from sugarcane molasses may accelerate copper phytoextraction. In this study, we evaluated the facilitatory effect of MLP on phytoextraction in a medium including cadmium or lead, the concentrations of which were adjusted around the regulation values of the Soil Contamination Countermeasures Act in Japan. Three Brassica species were tested based on their fast growth, high biomass productivity, and high heavy metal absorption. Both biomass and lead uptake in the nutrient medium with 1 mM lead nitrate were significantly increased by the addition of MLP, and almost all of the lead was accumulated in the root tissue. Therefore, MLP were able both to detoxify lead ions and to improve their bioavailability in Brassica species. In contrast, only these species with MLP or citric acid survived in the nutrient medium with 1 mM cadmium sulfate. The phytoextraction of cadmium using these species was therefore impractical under the Act.

The exploration about the means of lunar-landing based on space-launch

NASA Astrophysics Data System (ADS)

Yi, Jiang; Zheming, Zhang; Debin, Fu

The lunar exploration and lunar-landing is the first step of china s deep space exploration On the basement of our country s achievements and the experiences of the foreign countries the paper brings forward the idea that use the existing transportation technology to sent the Launch vehicles and cosmonauts to the near-earth orbit in batches assemble the components together on the Space-launch Platform and then launch them to the Moon to fulfill our dream of manned landing on the moon The paper also discusses the Space-launch Platform and the launching way

Multiple lymphomatous polyposis.

PubMed

Kadayifçi, A; Benekli, M; Savaş, M C; Arslan, S; Uzunalimoğlu, B; Barişta, I; Güllü, I H; Tekuzman, G

1997-04-01

Multiple lymphomatous polyposis (MLP) is a distinctive and particularly rare clinical type of malignant gastrointestinal lymphoma, which is classified as B-cell centrocytic non-Hodgkin's lymphoma. this rare entity has been recently reclassified as mantle cell lymphoma. We herein report three additional cases of MLP involving various segments of the gastrointestinal tract. MLP has an aggressive biologic behavior and a relatively poor prognosis and must be treated accordingly as a high-grade lymphoma with systemic chemotherapy.

a Rough Set Decision Tree Based Mlp-Cnn for Very High Resolution Remotely Sensed Image Classification

NASA Astrophysics Data System (ADS)

Zhang, C.; Pan, X.; Zhang, S. Q.; Li, H. P.; Atkinson, P. M.

2017-09-01

Recent advances in remote sensing have witnessed a great amount of very high resolution (VHR) images acquired at sub-metre spatial resolution. These VHR remotely sensed data has post enormous challenges in processing, analysing and classifying them effectively due to the high spatial complexity and heterogeneity. Although many computer-aid classification methods that based on machine learning approaches have been developed over the past decades, most of them are developed toward pixel level spectral differentiation, e.g. Multi-Layer Perceptron (MLP), which are unable to exploit abundant spatial details within VHR images. This paper introduced a rough set model as a general framework to objectively characterize the uncertainty in CNN classification results, and further partition them into correctness and incorrectness on the map. The correct classification regions of CNN were trusted and maintained, whereas the misclassification areas were reclassified using a decision tree with both CNN and MLP. The effectiveness of the proposed rough set decision tree based MLP-CNN was tested using an urban area at Bournemouth, United Kingdom. The MLP-CNN, well capturing the complementarity between CNN and MLP through the rough set based decision tree, achieved the best classification performance both visually and numerically. Therefore, this research paves the way to achieve fully automatic and effective VHR image classification.

Assessing the clinical effectiveness of an algorithmic approach for mucosal lichen planus (MLP): A retrospective review.

PubMed

Ashack, Kurt A; Haley, Laura L; Luther, Chelsea A; Riemer, Christie A; Ashack, Richard J

2016-06-01

Mucosal lichen planus (MLP) is a therapeutic challenge in need of a new treatment approach because of its debilitating effect on patient's quality of life. We sought to evaluate a standardized treatment plan for patients with MLP. A second objective was to describe the effect of mycophenolate mofetil in this patient population. The study retrospectively analyzed 53 patients with MLP treated using a standardized algorithm. The number of MLP lesions, disease activity, and pain at the last visit were compared with baseline scores determined at the initial visit. Results were analyzed using the paired samples t test and confirmed with the Wilcoxon matched pairs signed rank test. The average number of lesions was reduced from 3.77 to 1.67 (P < .001). The average disease activity was reduced from 2.73 to 0.90 (P < .001). Average pain reported decreased from 2.03 to 1.03 (P < .001). This study was a retrospective analysis of a small patient population. There was no universal symptom severity scale used at the time of treatment for some patients. The standardized treatment plan reduced symptoms for patients with MLP. Mycophenolate mofetil appears to be a reasonable treatment option for these patients. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Nociceptive DRG neurons express muscle lim protein upon axonal injury.

PubMed

Levin, Evgeny; Andreadaki, Anastasia; Gobrecht, Philipp; Bosse, Frank; Fischer, Dietmar

2017-04-04

Muscle lim protein (MLP) has long been regarded as a cytosolic and nuclear muscular protein. Here, we show that MLP is also expressed in a subpopulation of adult rat dorsal root ganglia (DRG) neurons in response to axonal injury, while the protein was not detectable in naïve cells. Detailed immunohistochemical analysis of L4/L5 DRG revealed ~3% of MLP-positive neurons 2 days after complete sciatic nerve crush and maximum ~10% after 4-14 days. Similarly, in mixed cultures from cervical, thoracic, lumbar and sacral DRG ~6% of neurons were MLP-positive after 2 days and maximal 17% after 3 days. In both, histological sections and cell cultures, the protein was detected in the cytosol and axons of small diameter cells, while the nucleus remained devoid. Moreover, the vast majority could not be assigned to any of the well characterized canonical DRG subpopulations at 7 days after nerve injury. However, further analysis in cell culture revealed that the largest population of MLP expressing cells originated from non-peptidergic IB4-positive nociceptive neurons, which lose their ability to bind the lectin upon axotomy. Thus, MLP is mostly expressed in a subset of axotomized nociceptive neurons and can be used as a novel marker for this population of cells.

Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity

PubMed Central

Holden, Jennifer M.; Koreny, Ludek; Obado, Samson; Ratushny, Alexander V.; Chen, Wei-Ming; Chiang, Jung-Hsien; Kelly, Steven; Chait, Brian T.; Aitchison, John D.; Rout, Michael P.; Field, Mark C.

2014-01-01

The nuclear pore complex (NPC) has dual roles in nucleocytoplasmic transport and chromatin organization. In many eukaryotes the coiled-coil Mlp/Tpr proteins of the NPC nuclear basket have specific functions in interactions with chromatin and defining specialized regions of active transcription, whereas Mlp2 associates with the mitotic spindle/NPC in a cell cycle–dependent manner. We previously identified two putative Mlp-related proteins in African trypanosomes, TbNup110 and TbNup92, the latter of which associates with the spindle. We now provide evidence for independent ancestry for TbNup92/TbNup110 and Mlp/Tpr proteins. However, TbNup92 is required for correct chromosome segregation, with knockout cells exhibiting microaneuploidy and lowered fidelity of telomere segregation. Further, TbNup92 is intimately associated with the mitotic spindle and spindle anchor site but apparently has minimal roles in control of gene transcription, indicating that TbNup92 lacks major barrier activity. TbNup92 therefore acts as a functional analogue of Mlp/Tpr proteins, and, together with the lamina analogue NUP-1, represents a cohort of novel proteins operating at the nuclear periphery of trypanosomes, uncovering complex evolutionary trajectories for the NPC and nuclear lamina. PMID:24600046

A comparison study between MLP and convolutional neural network models for character recognition

NASA Astrophysics Data System (ADS)

Ben Driss, S.; Soua, M.; Kachouri, R.; Akil, M.

2017-05-01

Optical Character Recognition (OCR) systems have been designed to operate on text contained in scanned documents and images. They include text detection and character recognition in which characters are described then classified. In the classification step, characters are identified according to their features or template descriptions. Then, a given classifier is employed to identify characters. In this context, we have proposed the unified character descriptor (UCD) to represent characters based on their features. Then, matching was employed to ensure the classification. This recognition scheme performs a good OCR Accuracy on homogeneous scanned documents, however it cannot discriminate characters with high font variation and distortion.3 To improve recognition, classifiers based on neural networks can be used. The multilayer perceptron (MLP) ensures high recognition accuracy when performing a robust training. Moreover, the convolutional neural network (CNN), is gaining nowadays a lot of popularity for its high performance. Furthermore, both CNN and MLP may suffer from the large amount of computation in the training phase. In this paper, we establish a comparison between MLP and CNN. We provide MLP with the UCD descriptor and the appropriate network configuration. For CNN, we employ the convolutional network designed for handwritten and machine-printed character recognition (Lenet-5) and we adapt it to support 62 classes, including both digits and characters. In addition, GPU parallelization is studied to speed up both of MLP and CNN classifiers. Based on our experimentations, we demonstrate that the used real-time CNN is 2x more relevant than MLP when classifying characters.

The Magnetic Levator Prosthesis for Temporary Management of Severe Blepharoptosis: Initial Safety and Efficacy

PubMed Central

Houston, Kevin E.; Tomasi, Matteo; Amaral, Christina; Finch, Nicole; Yoon, Michael K.; Lee, Hang; Paschalis, Eleftherios I.

2018-01-01

Purpose We further optimized and evaluated the safety of the magnetic levator prosthesis (MLP) for temporary management of severe blepharoptosis, and compared efficacy and comfort against the ptosis crutch. Methods The interpalpebral fissure (IPF) of participants (n = 12) with ptosis was measured during attempted eyelid opening, volitional closing, and spontaneous closing with no device, ptosis crutch, or the MLP. A 10-point scale documented comfort. Additionally, a 20 minute and then 1 week trial of the MLP was offered. Safety measures were skin erythema rating, change in visual acuity, and change in corneal staining. Results The MLP and crutch opened the eye (IPF 11.2 and 9.3 mm), but the MLP allowed better volitional closure (IPF 1.0 vs. 4.9 mm, P = 0.009), but was no better in allowing spontaneous blink (IPF 7.5 vs. 7.7 mm, P = 0.722). Both devices were equally comfortable (both median 8/10 comfort, P = 0.46). With extended use, opening with the MLP showed IPF 9.24 mm at 20 minutes and 9.46 mm at 1 week, and volitional closure was IPF 0.95 and 0.52 mm, respectively. Closure on spontaneous blink improved with extended wear to IPF 5.14 and 5.18 mm, respectively (P = 0.002). Two participants exhibited moderate skin erythema and one had increased corneal staining without change in acuity. Conclusions The MLP is safe and feasible for temporary correction of severe ptosis. Translational Relevance First group data in patients showing successful reanimation of the eyelid with magnetic force. PMID:29367892

Proteomic Identification of Putative MicroRNA394 Target Genes in Arabidopsis thaliana Identifies Major Latex Protein Family Members Critical for Normal Development*

PubMed Central

Litholdo, Celso G.; Parker, Benjamin L.; Eamens, Andrew L.; Larsen, Martin R.; Cordwell, Stuart J.; Waterhouse, Peter M.

2016-01-01

Expression of the F-Box protein Leaf Curling Responsiveness (LCR) is regulated by microRNA, miR394, and alterations to this interplay in Arabidopsis thaliana produce defects in leaf polarity and shoot apical meristem organization. Although the miR394-LCR node has been documented in Arabidopsis, the identification of proteins targeted by LCR F-box itself has proven problematic. Here, a proteomic analysis of shoot apices from plants with altered LCR levels identified a member of the Latex Protein (MLP) family gene as a potential LCR F-box target. Bioinformatic and molecular analyses also suggested that other MLP family members are likely to be targets for this post-translational regulation. Direct interaction between LCR F-Box and MLP423 was validated. Additional MLP members had reduction in protein accumulation, in varying degrees, mediated by LCR F-Box. Transgenic Arabidopsis lines, in which MLP28 expression was reduced through an artificial miRNA technology, displayed severe developmental defects, including changes in leaf patterning and morphology, shoot apex defects, and eventual premature death. These phenotypic characteristics resemble those of Arabidopsis plants modified to over-express LCR. Taken together, the results demonstrate that MLPs are driven to degradation by LCR, and indicate that MLP gene family is target of miR394-LCR regulatory node, representing potential targets for directly post-translational regulation mediated by LCR F-Box. In addition, MLP28 family member is associated with the LCR regulation that is critical for normal Arabidopsis development. PMID:27067051

76 FR 21087 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... developed an enhanced technology trading platform (the ``Optimise platform''). To assure a smooth transition... Optimise trading platform and will continue to do so up to the launch of the new technology and during the... tested and is available for the launch. The Exchange believes that it will be less disruptive to members...

Real-time and simultaneous control of artificial limbs based on pattern recognition algorithms.

PubMed

Ortiz-Catalan, Max; Håkansson, Bo; Brånemark, Rickard

2014-07-01

The prediction of simultaneous limb motions is a highly desirable feature for the control of artificial limbs. In this work, we investigate different classification strategies for individual and simultaneous movements based on pattern recognition of myoelectric signals. Our results suggest that any classifier can be potentially employed in the prediction of simultaneous movements if arranged in a distributed topology. On the other hand, classifiers inherently capable of simultaneous predictions, such as the multi-layer perceptron (MLP), were found to be more cost effective, as they can be successfully employed in their simplest form. In the prediction of individual movements, the one-vs-one (OVO) topology was found to improve classification accuracy across different classifiers and it was therefore used to benchmark the benefits of simultaneous control. As opposed to previous work reporting only offline accuracy, the classification performance and the resulting controllability are evaluated in real time using the motion test and target achievement control (TAC) test, respectively. We propose a simultaneous classification strategy based on MLP that outperformed a top classifier for individual movements (LDA-OVO), thus improving the state-of-the-art classification approach. Furthermore, all the presented classification strategies and data collected in this study are freely available in BioPatRec, an open source platform for the development of advanced prosthetic control strategies.

Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure

PubMed Central

Paudyal, Anju; Dewan, Sukriti; Ikie, Cindy; Whalley, Benjamin J; de Tombe, Pieter P.

2016-01-01

Key points The present study investigated the mechanism associated with impaired cardiac mechanosensing that leads to heart failure by examining the factors regulating muscle LIM protein subcellular distribution in myocytes.In myocytes, muscle LIM protein subcellular distribution is regulated by cell contractility rather than passive stretch via heme oxygenase‐1 and histone deacetylase signalling. The result of the present study provide new insights into mechanotransduction in cardiac myocytes.Myocyte mechanosensitivity, as indicated by the muscle LIM protein ratio, is also correlated with cardiac function in the transition to failure in a guinea‐pig model of disease. This shows that the loss mechanosensitivity plays an important role during the transition to failure in the heart.The present study provides the first indication that mechanosensing could be modified pharmacologically during the transition to heart failure. Abstract Impaired mechanosensing leads to heart failure and a decreased ratio of cytoplasmic to nuclear CSRP3/muscle LIM protein (MLP ratio) is associated with a loss of mechanosensitivity. In the present study, we tested whether passive or active stress/strain was important in modulating the MLP ratio and determined whether this correlated with heart function during the transition to failure. We exposed cultured neonatal rat myocytes to a 10% cyclic mechanical stretch at 1 Hz, or electrically paced myocytes at 6.8 V (1 Hz) for 48 h. The MLP ratio decreased by 50% (P < 0.05, n = 4) only in response to electrical pacing, suggesting impaired mechanosensitivity. Inhibition of contractility with 10 μm blebbistatin resulted in an ∼3‐fold increase in the MLP ratio (n = 8, P < 0.05), indicating that myocyte contractility regulates nuclear MLP. Inhibition of histone deacetylase (HDAC) signalling with trichostatin A increased nuclear MLP following passive stretch, suggesting that HDACs block MLP nuclear accumulation. Inhibition of heme oxygenase1 (HO‐1) activity with protoporphyrin IX zinc(II) blocked MLP nuclear accumulation. To examine how mechanosensitivity changes during the transition to heart failure, we studied a guinea‐pig model of angiotensin II infusion (400 ng kg–1 min–1) over 12 weeks. Using subcellular fractionation, we showed that the MLP ratio increased by 88% (n = 4, P < 0.01) during compensated hypertrophy but decreased significantly during heart failure (P < 0.001, n = 4). The MLP ratio correlated significantly with the E/A ratio (r = 0.71, P < 0.01, n = 12), a clinical measure of diastolic function. These data indicate for the first time that myocyte mechanosensitivity as indicated by the MLP ratio is regulated primarily by myocyte contractility via HO‐1 and HDAC signalling. PMID:26847743

Proteomic Identification of Putative MicroRNA394 Target Genes in Arabidopsis thaliana Identifies Major Latex Protein Family Members Critical for Normal Development.

PubMed

Litholdo, Celso G; Parker, Benjamin L; Eamens, Andrew L; Larsen, Martin R; Cordwell, Stuart J; Waterhouse, Peter M

2016-06-01

Expression of the F-Box protein Leaf Curling Responsiveness (LCR) is regulated by microRNA, miR394, and alterations to this interplay in Arabidopsis thaliana produce defects in leaf polarity and shoot apical meristem organization. Although the miR394-LCR node has been documented in Arabidopsis, the identification of proteins targeted by LCR F-box itself has proven problematic. Here, a proteomic analysis of shoot apices from plants with altered LCR levels identified a member of the Latex Protein (MLP) family gene as a potential LCR F-box target. Bioinformatic and molecular analyses also suggested that other MLP family members are likely to be targets for this post-translational regulation. Direct interaction between LCR F-Box and MLP423 was validated. Additional MLP members had reduction in protein accumulation, in varying degrees, mediated by LCR F-Box. Transgenic Arabidopsis lines, in which MLP28 expression was reduced through an artificial miRNA technology, displayed severe developmental defects, including changes in leaf patterning and morphology, shoot apex defects, and eventual premature death. These phenotypic characteristics resemble those of Arabidopsis plants modified to over-express LCR Taken together, the results demonstrate that MLPs are driven to degradation by LCR, and indicate that MLP gene family is target of miR394-LCR regulatory node, representing potential targets for directly post-translational regulation mediated by LCR F-Box. In addition, MLP28 family member is associated with the LCR regulation that is critical for normal Arabidopsis development. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Genome-wide evolutionary characterization and expression analyses of major latex protein (MLP) family genes in Vitis vinifera.

PubMed

Zhang, Ningbo; Li, Ruimin; Shen, Wei; Jiao, Shuzhen; Zhang, Junxiang; Xu, Weirong

2018-04-27

The major latex protein/ripening-related protein (MLP/RRP) subfamily is known to be involved in a wide range of biological processes of plant development and various stress responses. However, the biological function of MLP/RRP proteins is still far from being clear and identification of them may provide important clues for understanding their roles. Here, we report a genome-wide evolutionary characterization and gene expression analysis of the MLP family in European Vitis species. A total of 14 members, was found in the grape genome, all of which are located on chromosome 1, where are predominantly arranged in tandem clusters. We have noticed, most surprisingly, promoter-sharing by several non-identical but highly similar gene members to a greater extent than expected by chance. Synteny analysis between the grape and Arabidopsis thaliana genomes suggested that 3 grape MLP genes arose before the divergence of the two species. Phylogenetic analysis provided further insights into the evolutionary relationship between the genes, as well as their putative functions, and tissue-specific expression analysis suggested distinct biological roles for different members. Our expression data suggested a couple of candidate genes involved in abiotic stresses and phytohormone responses. The present work provides new insight into the evolution and regulation of Vitis MLP genes, which represent targets for future studies and inclusion in tolerance-related molecular breeding programs.

FMLP provokes coronary vasoconstriction and myocardial ischemia in rabbits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gillespie, M.N.; Booth, D.C.; Friedman, B.J.

Recent pathological studies of coronary arteries from humans with suspected coronary spasm have revealed an augmented intramural burden of inflammatory cells. To test the hypothesis than inappropriate activation of inflammatory cells participates in the evolution of coronary vasospasm, the present experiment employed a newly developed coronary arteriographic technique for use in pentobarbital-anesthetized rabbits to evaluate the coronary vasomotor actions of the nonselective inflammatory cell stimulant, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). In 10 of 10 animals, selective left intracoronary injection of 200 ng fMLP evoked profound left coronary narrowing accompanied in all cases by ST segment deviation and dysrhythmias. Thallium-201 scintigraphy demonstrated hypoperfusion ofmore » the left ventricular free wall and septum supplied by the spastic coronary artery. The fMLP-induced epicardial vasoconstriction, ischemic electrocardiogram (ECG) changes, and thallium perfusion defects were reversed by intravenous nitroglycerin. Neither the right coronary artery nor its distribution were influenced by left coronary injection of fMLP. Additional experiments in isolated, salt solution-perfused rabbit hearts demonstrated that fMLP failed to exert direct coronary vasoconstrictor effects. These observations indicate that the nonselective inflammatory cell stimulant, fMLP, provokes arteriographically demonstrable coronary spasm with attendant myocardial hypoperfusion and ischemic ECG changes in anesthetized rabbits. Such a model may be useful in exploring the dynamic role of inflammatory cells in development of coronary spasm.« less

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.

PubMed

García-Benítez, Francisco; Gaillard, Hélène; Aguilera, Andrés

2017-10-10

During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic cells prevent harmful R loops, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R loops. A screening of 400 Saccharomyces cerevisiae selected strains deleted in nuclear genes revealed that cells lacking the Mlp1/2 nuclear basket proteins show AID-dependent genomic instability and replication defects that were suppressed by RNase H1 overexpression. Importantly, DNA-RNA hybrids accumulated at transcribed genes in mlp1/2 mutants, indicating that Mlp1/2 prevents R loops. Consistent with the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuclear periphery of a transcribed locus suppressed R loops in mlp1 ∆ cells. The same occurred in THO-deficient hpr1 ∆ cells. We conclude that proximity of transcribed chromatin to the nuclear pore helps restrain pathological R loops.

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

Perched on the Mobile Launch Platform, in the early morning hours Space Shuttle Discovery approaches Launch Complex Pad 39B after a 6-hour, 4.2-mile trip from the Vehicle Assembly Building. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

Lactate oxidation coupled to energy production in mitochondria like particles from Setaria digitata, a filarial parasite.

PubMed

Sivan, V M; Raj, R K

1994-10-14

In the filarial parasite, Setaria digitata, the mitochondria like particles (MLP) show NAD reduction with sodium lactate. The MLP also reduces dye and ferricyanide with lactate. The ferricyanide reduction by lactate is found to be sensitive to the cytochrome o inhibitor orthohydroxy diphenyl (OHD) and complex I inhibitor rotenone, modulated by ADP (+) and ATP (-) and inhibited by pyruvate and oxaloacetate. MLP shows lactate oxidation sensitive to OHD, rotenone and sodium malonate. Thus, the lactate utilizing complex system, consisting of an NADH generating MLP bound lactate dehydrogenase and a lactate flavocytochrome reductase tightly linked to complex I and cytochrome o, produces ATP in functional association with fumarate reductase complex and other enzyme systems. Hence, this study provides new dimensions to the study of metabolism in filarial parasites.

Prediction of heart abnormality using MLP network

NASA Astrophysics Data System (ADS)

Hashim, Fakroul Ridzuan; Januar, Yulni; Mat, Muhammad Hadzren; Rizman, Zairi Ismael; Awang, Mat Kamil

2018-02-01

Heart abnormality does not choose gender, age and races when it strikes. With no warning signs or symptoms, it can result to a sudden death of the patient. Generally, heart's irregular electrical activity is defined as heart abnormality. Via implementation of Multilayer Perceptron (MLP) network, this paper tries to develop a program that allows the detection of heart abnormality activity. Utilizing several training algorithms with Purelin activation function, an amount of heartbeat signals received through the electrocardiogram (ECG) will be employed to condition the MLP network.

Efficacy of mangrove leaf powder for bioremediation of chromium (VI) from aqueous solutions: kinetic and thermodynamic evaluation

NASA Astrophysics Data System (ADS)

Sathish, Thadikamala; Vinithkumar, N. V.; Dharani, G.; Kirubagaran, R.

2015-06-01

Biosorption of heavy metals by bio-materials has been posited as a potential alternative to the existing physicochemical technologies for detoxification and recovery of toxic and valuable metals from wastewaters. In this context, the role of mangrove leaf powder (MLP) as biosorbent for chromium removal was investigated. In the present study, the effect of process parameters such as particle size, solution pH, initial concentration of Cr(VI) ion and adsorbent dose on chromium removal by MLP was investigated. The maximum sorption was observed at particle size 0.5 mm and pH 2.0. The adsorption data follow the pseudo second-order kinetics model. The isotherms denote that Langmuir model is the best fitted than Freundlich model. The maximum adsorption capacity ( Q 0) of 60.24 mg/g of Cr(VI) at 30 min on MLP was determined using the Langmuir model. The adsorption isotherm model indicates that the chromium is adsorbing as monolayer on the surface of MLP with heterogeneous energetic distribution of active sites. Various thermodynamic parameters, such as Gibb's free energy (∆ G °), enthalpy (∆ H °) and entropy (∆ S °) have been calculated. The thermodynamic data revealed that the adsorption of chromium ions onto MLP is endothermic in nature and a spontaneous process. The results of the present study suggest that MLP is an effective bioremediation measure for removal of high concentration of Cr(VI) in waste waters.

Two views of the 'Challenger' being rolled out to pad 39A in the fog STS-6

NASA Technical Reports Server (NTRS)

1982-01-01

Two views of the 'Challenger' being rolled out to pad 39A in the fog in preparation for STS-6. In one view the Challenger, atop a mobile launch platform, slowly moves down the road through Florida fog to launch pad 39A (41140); In this view, the Challenger and its mobile launch platform are in the left corner of the photo, moving up the road in dense fog. Towards the top of the view, launch pad 39A can be seen (41141).

Progress in Unsteady Turbopump Flow Simulations Using Overset Grid Systems

NASA Technical Reports Server (NTRS)

Kiris, Cetin C.; Chan, William; Kwak, Dochan

2002-01-01

This viewgraph presentation provides information on unsteady flow simulations for the Second Generation RLV (Reusable Launch Vehicle) baseline turbopump. Three impeller rotations were simulated by using a 34.3 million grid points model. MPI/OpenMP hybrid parallelism and MLP shared memory parallelism has been implemented and benchmarked in INS3D, an incompressible Navier-Stokes solver. For RLV turbopump simulations a speed up of more than 30 times has been obtained. Moving boundary capability is obtained by using the DCF module. Scripting capability from CAD geometry to solution is developed. Unsteady flow simulations for advanced consortium impeller/diffuser by using a 39 million grid points model are currently underway. 1.2 impeller rotations are completed. The fluid/structure coupling is initiated.

Tansig activation function (of MLP network) for cardiac abnormality detection

NASA Astrophysics Data System (ADS)

Adnan, Ja'afar; Daud, Nik Ghazali Nik; Ishak, Mohd Taufiq; Rizman, Zairi Ismael; Rahman, Muhammad Izzuddin Abd

2018-02-01

Heart abnormality often occurs regardless of gender, age and races. This problem sometimes does not show any symptoms and it can cause a sudden death to the patient. In general, heart abnormality is the irregular electrical activity of the heart. This paper attempts to develop a program that can detect heart abnormality activity through implementation of Multilayer Perceptron (MLP) network. A certain amount of data of the heartbeat signals from the electrocardiogram (ECG) will be used in this project to train the MLP network by using several training algorithms with Tansig activation function.

Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages.

PubMed

Nagasawa, Masahiro; Nakagawa, Yuko; Tanaka, Shigeyasu; Kojima, Itaru

2007-03-01

The present study was conducted to characterize the regulation and function of TRPV2 in macrophages. Among six members of the TRPV family channels, only the expression of TRPV2 was detected in macrophages. We then determined localization of TRPV2 using TtT/M87 macrophages transfected with TRPV2-EGFP. In serum-free condition, most of the TRPV2 signal was located in the cytoplasm and colocalized with the endoplasmic reticulum marker. Treatment with serum induced translocation of some of the TRPV2-EGFP to the plasma membrane. Serum-induced translocation was blocked by transfection of short-form TRPV2 (s-TRPV2) lacking a pore-forming region and the sixth transmembrane domain. Addition of a chemotactic peptide formyl Met-Leu-Phe (fMLP) also induced translocation of TRPV2-EGFP to the plasma membrane. The fMLP-induced translocation was blocked by an inhibitor of PI 3-kinase, LY294002, and pertussis toxin. Whole-cell patch clamp analysis showed a Cs+ current in the TtT/M87 cell, which was blocked by an addition of ruthenium red and transfection of either s-TRPV2 or siRNA for TRPV2. fMLP increased the Cs+ current. fMLP induced a rapid and sustained elevation of cytoplasmic Ca2+ ([Ca2+]C), the sustained phase of which was abolished by removal of extracellular calcium. The sustained elevation of [Ca2+]C was also blocked by ruthenium red, and transfection of either s-TRPV2 or siRNA. Finally, fMLP-induced migration of macrophage was blocked by ruthenium red or transfection of s-TRPV2. These results suggest that fMLP induces translocation of TRPV2 from intracellular compartment to the plasma membrane, and this translocation is critical for fMLP-induced calcium entry. Copyright 2006 Wiley-Liss, Inc.

“Extra Oomph:” Addressing Housing Disparities through Medical Legal Partnership Interventions

PubMed Central

Hernández, Diana

2016-01-01

Low-income households face common and chronic housing problems that have known health risks and legal remedies. The Medical Legal Partnership (MLP) program presents a unique opportunity to address housing problems and improve patient health through legal assistance offered in clinical settings. Drawn from in-depth interviews with 72 patients, this study investigated the outcomes of MLP interventions and compares results to similarly disadvantaged participants with no access to MLP services. Results indicate that participants in the MLP group were more likely to achieve adequate, affordable and stable housing than those in the comparison group. Study findings suggest that providing access to legal services in the healthcare setting can effectively address widespread health disparities rooted in problematic housing. Implications for policy and scalability are discussed with the conclusion that MLPs can shift professionals’ consciousness as they work to improve housing and health trajectories for indigent groups using legal approaches. PMID:27867247

External Payload Carrier (XPC) - A Novel Platform for Suborbital Research

NASA Technical Reports Server (NTRS)

Schallhorn, Paul; Groves, Curtis; Tatro, Charles; Kutter, Bernard; Szatkowski, Gerald; Bulk, Tim; Pitchford, Brian

2010-01-01

ULA, SAS, and NASA LSP are examining a new platform for suborbital research utilizing the Atlas V Launch Vehicle. The new platform, XPC, fills a new niche within the suborbital realm Large Heavy Lift (approximately 1200 cubic feet, 5000 lb payload). It will not compete with the commercial suborbital launch sector. The XPC will utilize excess performance on Atlas V missions. The Preliminary Design phase is recently underway. The XPC team is soliciting input from potential users.

KSC-2009-1567

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

KSC-2009-1566

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

KSC-2009-1568

NASA Image and Video Library

2009-02-12

CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett

Supercomputing Aspects for Simulating Incompressible Flow

NASA Technical Reports Server (NTRS)

Kwak, Dochan; Kris, Cetin C.

2000-01-01

The primary objective of this research is to support the design of liquid rocket systems for the Advanced Space Transportation System. Since the space launch systems in the near future are likely to rely on liquid rocket engines, increasing the efficiency and reliability of the engine components is an important task. One of the major problems in the liquid rocket engine is to understand fluid dynamics of fuel and oxidizer flows from the fuel tank to plume. Understanding the flow through the entire turbo-pump geometry through numerical simulation will be of significant value toward design. One of the milestones of this effort is to develop, apply and demonstrate the capability and accuracy of 3D CFD methods as efficient design analysis tools on high performance computer platforms. The development of the Message Passage Interface (MPI) and Multi Level Parallel (MLP) versions of the INS3D code is currently underway. The serial version of INS3D code is a multidimensional incompressible Navier-Stokes solver based on overset grid technology, INS3D-MPI is based on the explicit massage-passing interface across processors and is primarily suited for distributed memory systems. INS3D-MLP is based on multi-level parallel method and is suitable for distributed-shared memory systems. For the entire turbo-pump simulations, moving boundary capability and efficient time-accurate integration methods are built in the flow solver, To handle the geometric complexity and moving boundary problems, an overset grid scheme is incorporated with the solver so that new connectivity data will be obtained at each time step. The Chimera overlapped grid scheme allows subdomains move relative to each other, and provides a great flexibility when the boundary movement creates large displacements. Two numerical procedures, one based on artificial compressibility method and the other pressure projection method, are outlined for obtaining time-accurate solutions of the incompressible Navier-Stokes equations. The performance of the two methods is compared by obtaining unsteady solutions for the evolution of twin vortices behind a flat plate. Calculated results are compared with experimental and other numerical results. For an unsteady flow, which requires small physical time step, the pressure projection method was found to be computationally efficient since it does not require any subiteration procedure. It was observed that the artificial compressibility method requires a fast convergence scheme at each physical time step in order to satisfy the incompressibility condition. This was obtained by using a GMRES-ILU(0) solver in present computations. When a line-relaxation scheme was used, the time accuracy was degraded and time-accurate computations became very expensive.

Adsorption of malachite green by magnetic litchi pericarps: A response surface methodology investigation.

PubMed

Zheng, Hao; Qi, Jinqiu; Jiang, Ruixue; Gao, Yan; Li, Xiaochen

2015-10-01

In this work, we synthesized a novel magnetic adsorbent containing litchi pericarps, denoted as MLP, for the removal of malachite green (MG) from solution. The factors influencing MG adsorption, such as contact time, adsorbent dosage, and initial dye concentration, were optimized using the Box-Behnken response surface methodology (RSM). The adsorption isotherms as well as the kinetics and thermodynamics of the adsorption of MG onto MLP are discussed. The results showed that MLP has a maximum adsorption efficiency of 99.5% when the temperature, pH, contact time, adsorbent dosage, and initial MG concentration were optimally set as 25 °C, 6.0, 66.69 min, 5.14 g/L, and 150 mg/L, respectively. The best model to describe this process is the Langmuir isotherm, with the maximum adsorption capacity being 70.42 mg/g. In addition, the kinetics of MG adsorption onto MLP followed a pseudo-second-order model; moreover, thermodynamic analysis suggested that MG adsorption onto MLP is spontaneous and endothermic. Finally, it was found that the new magnetic adsorbent can be separated easily and rapidly from mixed solutions in the presence of an external magnetic field. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Direct Position-Determination Approach for Multiple Sources Based on Neural Network Computation.

PubMed

Chen, Xin; Wang, Ding; Yin, Jiexin; Wu, Ying

2018-06-13

The most widely used localization technology is the two-step method that localizes transmitters by measuring one or more specified positioning parameters. Direct position determination (DPD) is a promising technique that directly localizes transmitters from sensor outputs and can offer superior localization performance. However, existing DPD algorithms such as maximum likelihood (ML)-based and multiple signal classification (MUSIC)-based estimations are computationally expensive, making it difficult to satisfy real-time demands. To solve this problem, we propose the use of a modular neural network for multiple-source DPD. In this method, the area of interest is divided into multiple sub-areas. Multilayer perceptron (MLP) neural networks are employed to detect the presence of a source in a sub-area and filter sources in other sub-areas, and radial basis function (RBF) neural networks are utilized for position estimation. Simulation results show that a number of appropriately trained neural networks can be successfully used for DPD. The performance of the proposed MLP-MLP-RBF method is comparable to the performance of the conventional MUSIC-based DPD algorithm for various signal-to-noise ratios and signal power ratios. Furthermore, the MLP-MLP-RBF network is less computationally intensive than the classical DPD algorithm and is therefore an attractive choice for real-time applications.

KENNEDY SPACE CENTER, FLA. - A worker sandblasts the surface behind the Mobile Launcher Platform on Launch Pad 39A . Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - A worker sandblasts the surface behind the Mobile Launcher Platform on Launch Pad 39A . Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

Surrounded by work platforms, the full-scale Orion AFT crew module (center) is undergoing preparations for the first flight test of Orion's launch abort system.

NASA Image and Video Library

2008-05-20

Surrounded by work platforms, NASA's first full-scale Orion abort flight test (AFT) crew module (center) is undergoing preparations at the NASA Dryden Flight Research Center in California for the first flight test of Orion's launch abort system.

KSC-08pd1246

NASA Image and Video Library

2008-05-02

CAPE CANAVERAL, Fla. -- Artist's rendering of the Constellation Program's Ares V rocket on the mobile launcher platform (left) and the Ares I rocket on the platform (right) with the space shuttle in between for comparison. The tower of the mobile launcher will have multiple platforms for personnel access and will be approximately 390 feet tall. The tower will be used in the assembly, testing and servicing of the Ares rockets at Kennedy and will also transport the Ares rockets to the launch pad and provide ground support for launches.

Optimization of metformin HCl 500 mg sustained release matrix tablets using Artificial Neural Network (ANN) based on Multilayer Perceptrons (MLP) model.

PubMed

Mandal, Uttam; Gowda, Veeran; Ghosh, Animesh; Bose, Anirbandeep; Bhaumik, Uttam; Chatterjee, Bappaditya; Pal, Tapan Kumar

2008-02-01

The aim of the present study was to apply the simultaneous optimization method incorporating Artificial Neural Network (ANN) using Multi-layer Perceptron (MLP) model to the development of a metformin HCl 500 mg sustained release matrix tablets with an optimized in vitro release profile. The amounts of HPMC K15M and PVP K30 at three levels (-1, 0, +1) for each were selected as casual factors. In vitro dissolution time profiles at four different sampling times (1 h, 2 h, 4 h and 8 h) were chosen as output variables. 13 kinds of metformin matrix tablets were prepared according to a 2(3) factorial design (central composite) with five extra center points, and their dissolution tests were performed. Commercially available STATISTICA Neural Network software (Stat Soft, Inc., Tulsa, OK, U.S.A.) was used throughout the study. The training process of MLP was completed until a satisfactory value of root square mean (RSM) for the test data was obtained using feed forward back propagation method. The root mean square value for the trained network was 0.000097, which indicated that the optimal MLP model was reached. The optimal tablet formulation based on some predetermined release criteria predicted by MLP was 336 mg of HPMC K15M and 130 mg of PVP K30. Calculated difference (f(1) 2.19) and similarity (f(2) 89.79) factors indicated that there was no difference between predicted and experimentally observed drug release profiles for the optimal formulation. This work illustrates the potential for an artificial neural network with MLP, to assist in development of sustained release dosage forms.

Structures of two Arabidopsis thaliana major latex proteins represent novel helix-grip folds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lytle, Betsy L.; Song, Jikui; de la Cruz, Norberto B.

2009-06-02

Here we report the first structures of two major latex proteins (MLPs) which display unique structural differences from the canonical Bet v 1 fold described earlier. MLP28 (SwissProt/TrEMBL ID Q9SSK9), the product of gene At1g70830.1, and the At1g24000.1 gene product (Swiss- Prot/TrEMBL ID P0C0B0), proteins which share 32% sequence identity, were independently selected as foldspace targets by the Center for Eukaryotic Structural Genomics. The structure of a single domain (residues 17-173) of MLP28 was solved by NMR spectroscopy, while the full-length At1g24000.1 structure was determined by X-ray crystallography. MLP28 displays greater than 30% sequence identity to at least eight MLPsmore » from other species. For example, the MLP28 sequence shares 64% identity to peach Pp-MLP119 and 55% identity to cucumber Csf2.20 In contrast, the At1g24000.1 sequence is highly divergent (see Fig. 1), containing a gap of 33 amino acids when compared with all other known MLPs. Even when the gap is excluded, the sequence identity with MLPs from other species is less than 30%. Unlike some of the MLPs from other species, none of the A. thaliana MLPs have been characterized biochemically. We show by NMR chemical shift mapping that At1g24000.1 binds progesterone, demonstrating that despite its sequence dissimilarity, the hydrophobic binding pocket is conserved and, therefore, may play a role in its biological function and that of the MLP family in general.« less

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

Work is underway to secure the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket in High Bay 3 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform is being secured into position on tower E, about 86 feet above the floor. The K work platforms will provide access to NASA's Space Launch System (SLS) core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

1. AERIAL VIEW, SHOWING MOBILE LAUNCHER. BASE IS CALLED LAUNCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. AERIAL VIEW, SHOWING MOBILE LAUNCHER. BASE IS CALLED LAUNCH PLATFORM AND TOWER ON RIGHT IS CALLED LAUNCH UMBILICAL TOWER, (LUT). - Mobile Launcher One, Kennedy Space Center, Titusville, Brevard County, FL

Optimized hardware framework of MLP with random hidden layers for classification applications

NASA Astrophysics Data System (ADS)

Zyarah, Abdullah M.; Ramesh, Abhishek; Merkel, Cory; Kudithipudi, Dhireesha

2016-05-01

Multilayer Perceptron Networks with random hidden layers are very efficient at automatic feature extraction and offer significant performance improvements in the training process. They essentially employ large collection of fixed, random features, and are expedient for form-factor constrained embedded platforms. In this work, a reconfigurable and scalable architecture is proposed for the MLPs with random hidden layers with a customized building block based on CORDIC algorithm. The proposed architecture also exploits fixed point operations for area efficiency. The design is validated for classification on two different datasets. An accuracy of ~ 90% for MNIST dataset and 75% for gender classification on LFW dataset was observed. The hardware has 299 speed-up over the corresponding software realization.

KENNEDY SPACE CENTER, FLA. - Sandblasting begins on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - Sandblasting begins on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)

PubMed Central

Savic, Ivan M.; Nikolic, Vesna D.; Savic-Gajic, Ivana M.; Nikolic, Ljubisa B.; Ibric, Svetlana R.; Gajic, Dragoljub G.

2015-01-01

The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4°C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods. PMID:25972881

Computing and analyzing the sensitivity of MLP due to the errors of the i.i.d. inputs and weights based on CLT.

PubMed

Yang, Sheng-Sung; Ho, Chia-Lu; Siu, Sammy

2010-12-01

In this paper, we propose an algorithm based on the central limit theorem to compute the sensitivity of the multilayer perceptron (MLP) due to the errors of the inputs and weights. For simplicity and practicality, all inputs and weights studied here are independently identically distributed (i.i.d.). The theoretical results derived from the proposed algorithm show that the sensitivity of the MLP is affected by the number of layers and the number of neurons adopted in each layer. To prove the reliability of the proposed algorithm, some experimental results of the sensitivity are also presented, and they match the theoretical ones. The good agreement between the theoretical results and the experimental results verifies the reliability and feasibility of the proposed algorithm. Furthermore, the proposed algorithm can also be applied to compute precisely the sensitivity of the MLP with any available activation functions and any types of i.i.d. inputs and weights.

SiMA: A simplified migration assay for analyzing neutrophil migration.

PubMed

Weckmann, Markus; Becker, Tim; Nissen, Gyde; Pech, Martin; Kopp, Matthias V

2017-07-01

In lung inflammation, neutrophils are the first leukocytes migrating to an inflammatory site, eliminating pathogens by multiple mechanisms. The term "migration" describes several stages of neutrophil movement to reach the site of inflammation, of which the passage of the interstitium and basal membrane of the airway are necessary to reach the site of bronchial inflammation. Currently, several methods exist (e.g., Boyden Chamber, under-agarose assay, or microfluidic systems) to assess neutrophil mobility. However, these methods do not allow for parameterization on single cell level, that is, the individual neutrophil pathway analysis is still considered challenging. This study sought to develop a simplified yet flexible method to monitor and quantify neutrophil chemotaxis by utilizing commercially available tissue culture hardware, simple video microscopic equipment and highly standardized tracking. A chemotaxis 3D µ-slide (IBIDI) was used with different chemoattractants [interleukin-8 (IL-8), fMLP, and Leukotriene B4 (LTB 4 )] to attract neutrophils in different matrices like Fibronectin (FN) or human placental matrix. Migration was recorded for 60 min using phase contrast microscopy with an EVOS ® FL Cell Imaging System. The images were normalized and texture based image segmentation was used to generate neutrophil trajectories. Based on these spatio-temporal information a comprehensive parameter set is extracted from each time series describing the neutrophils motility, including velocity and directness and neutrophil chemotaxis. To characterize the latter one, a sector analysis was employed enabling the quantification of the neutrophils response to the chemoattractant. Using this hard- and software framework we were able to identify typical migration profiles of the chemoattractants IL-8, fMLP, and LTB 4 , the effect of the matrices FN versus HEM as well as the response to different medications (Prednisolone). Additionally, a comparison of four asthmatic and three non-asthmatic patients gives a first hint to the capability of SiMA assay in the context of migration based diagnostics. Using SiMA we were able to identify typical migration profiles of the chemoattractants IL-8, fMLP, and LTB 4 , the effect of the matrices FN versus HEM as well as the response to different medications, that is, Prednisolone induced a change of direction of migrating neutrophils in FN but no such effect was observed in human placental matrix. In addition, neutrophils of asthmatic individuals showed an increased proportion of cells migrating toward the vehicle. With the SiMA platform we presented a simplified but yet flexible platform for cost-effective tracking and quantification of neutrophil migration. The introduced method is based on a simple microscopic video stage, standardized, commercially available, µ-fluidic migration chambers and automated image analysis, and track validation software. © 2017 International Society for Advancement of Cytometry. © 2017 International Society for Advancement of Cytometry.

SU-F-E-09: Respiratory Signal Prediction Based On Multi-Layer Perceptron Neural Network Using Adjustable Training Samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, W; Jiang, M; Yin, F

Purpose: Dynamic tracking of moving organs, such as lung and liver tumors, under radiation therapy requires prediction of organ motions prior to delivery. The shift of moving organ may change a lot due to huge transform of respiration at different periods. This study aims to reduce the influence of that changes using adjustable training signals and multi-layer perceptron neural network (ASMLP). Methods: Respiratory signals obtained using a Real-time Position Management(RPM) device were used for this study. The ASMLP uses two multi-layer perceptron neural networks(MLPs) to infer respiration position alternately and the training sample will be updated with time. Firstly, amore » Savitzky-Golay finite impulse response smoothing filter was established to smooth the respiratory signal. Secondly, two same MLPs were developed to estimate respiratory position from its previous positions separately. Weights and thresholds were updated to minimize network errors according to Leverberg-Marquart optimization algorithm through backward propagation method. Finally, MLP 1 was used to predict 120∼150s respiration position using 0∼120s training signals. At the same time, MLP 2 was trained using 30∼150s training signals. Then MLP is used to predict 150∼180s training signals according to 30∼150s training signals. The respiration position is predicted as this way until it was finished. Results: In this experiment, the two methods were used to predict 2.5 minute respiratory signals. For predicting 1s ahead of response time, correlation coefficient was improved from 0.8250(MLP method) to 0.8856(ASMLP method). Besides, a 30% improvement of mean absolute error between MLP(0.1798 on average) and ASMLP(0.1267 on average) was achieved. For predicting 2s ahead of response time, correlation coefficient was improved from 0.61415 to 0.7098.Mean absolute error of MLP method(0.3111 on average) was reduced by 35% using ASMLP method(0.2020 on average). Conclusion: The preliminary results demonstrate that the ASMLP respiratory prediction method is more accurate than MLP method and can improve the respiration forecast accuracy.« less

Study of a Multigenerational Learning Program in Taiwan

ERIC Educational Resources Information Center

Chien, Hung-Ju; Tann, D. B.

2017-01-01

The aim of the Multigenerational Learning Program (MLP) is to increase multigenerational interactions through activities, which will help all learners including middle aged to older adults, university students, and children to improve multigenerational understanding, and increase their positive attitudes toward each other. The MLP activities were…

KSC-98pc1180

NASA Image and Video Library

1998-09-28

KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure, is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

As daylight creeps over the horizon, STS-95 Space Shuttle Discovery, on the Mobile Launch Platform, arrives at Launch Complex Pad 39B after a 4.2-mile trip taking approximately 6 hours. At the left is the 'white room,' attached to the orbiter access arm. The white room is an environmental chamber that mates with the orbiter and holds six persons. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar- observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

STS-30 Atlantis, OV-104, at KSC LC Pad 39B atop mobile launcher platform

NASA Technical Reports Server (NTRS)

1989-01-01

STS-30 Atlantis, Orbiter Vehicle (OV) 104, arrives at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39B atop mobile launcher platform. The fixed service structure (FSS) towers above OV-104, its external tank (ET), and its solid rocket boosters (SRBs). The rotating service structure (RSS) is retracted. The launch tower catwalks are also retracted.

[Magneto- laser-phoresis with heparin in the treatment of patients with chronic pharyngitis].

PubMed

Portenko, G M; Grafskaia, N A

2002-01-01

The results of treatment of various forms of chronic pharyngitis by magnetolaserophoresis (MLP) with heparin show that MLP is more effective in hypertrophic chronic pharyngitis. It is emphasized that when planning treatment of chronic pharyngitis one should take into consideration the state of the gastrointestinal tract.

Performance of the OVERFLOW-MLP and LAURA-MLP CFD Codes on the NASA Ames 512 CPU Origin System

NASA Technical Reports Server (NTRS)

Taft, James R.

2000-01-01

The shared memory Multi-Level Parallelism (MLP) technique, developed last year at NASA Ames has been very successful in dramatically improving the performance of important NASA CFD codes. This new and very simple parallel programming technique was first inserted into the OVERFLOW production CFD code in FY 1998. The OVERFLOW-MLP code's parallel performance scaled linearly to 256 CPUs on the NASA Ames 256 CPU Origin 2000 system (steger). Overall performance exceeded 20.1 GFLOP/s, or about 4.5x the performance of a dedicated 16 CPU C90 system. All of this was achieved without any major modification to the original vector based code. The OVERFLOW-MLP code is now in production on the inhouse Origin systems as well as being used offsite at commercial aerospace companies. Partially as a result of this work, NASA Ames has purchased a new 512 CPU Origin 2000 system to further test the limits of parallel performance for NASA codes of interest. This paper presents the performance obtained from the latest optimization efforts on this machine for the LAURA-MLP and OVERFLOW-MLP codes. The Langley Aerothermodynamics Upwind Relaxation Algorithm (LAURA) code is a key simulation tool in the development of the next generation shuttle, interplanetary reentry vehicles, and nearly all "X" plane development. This code sustains about 4-5 GFLOP/s on a dedicated 16 CPU C90. At this rate, expected workloads would require over 100 C90 CPU years of computing over the next few calendar years. It is not feasible to expect that this would be affordable or available to the user community. Dramatic performance gains on cheaper systems are needed. This code is expected to be perhaps the largest consumer of NASA Ames compute cycles per run in the coming year.The OVERFLOW CFD code is extensively used in the government and commercial aerospace communities to evaluate new aircraft designs. It is one of the largest consumers of NASA supercomputing cycles and large simulations of highly resolved full aircraft are routinely undertaken. Typical large problems might require 100s of Cray C90 CPU hours to complete. The dramatic performance gains with the 256 CPU steger system are exciting. Obtaining results in hours instead of months is revolutionizing the way in which aircraft manufacturers are looking at future aircraft simulation work. Figure 2 below is a current state of the art plot of OVERFLOW-MLP performance on the 512 CPU Lomax system. As can be seen, the chart indicates that OVERFLOW-MLP continues to scale linearly with CPU count up to 512 CPUs on a large 35 million point full aircraft RANS simulation. At this point performance is such that a fully converged simulation of 2500 time steps is completed in less than 2 hours of elapsed time. Further work over the next few weeks will improve the performance of this code even further.The LAURA code has been converted to the MLP format as well. This code is currently being optimized for the 512 CPU system. Performance statistics indicate that the goal of 100 GFLOP/s will be achieved by year's end. This amounts to 20x the 16 CPU C90 result and strongly demonstrates the viability of the new parallel systems rapidly solving very large simulations in a production environment.

Healthcare Text Classification System and its Performance Evaluation: A Source of Better Intelligence by Characterizing Healthcare Text.

PubMed

Srivastava, Saurabh Kumar; Singh, Sandeep Kumar; Suri, Jasjit S

2018-04-13

A machine learning (ML)-based text classification system has several classifiers. The performance evaluation (PE) of the ML system is typically driven by the training data size and the partition protocols used. Such systems lead to low accuracy because the text classification systems lack the ability to model the input text data in terms of noise characteristics. This research study proposes a concept of misrepresentation ratio (MRR) on input healthcare text data and models the PE criteria for validating the hypothesis. Further, such a novel system provides a platform to amalgamate several attributes of the ML system such as: data size, classifier type, partitioning protocol and percentage MRR. Our comprehensive data analysis consisted of five types of text data sets (TwitterA, WebKB4, Disease, Reuters (R8), and SMS); five kinds of classifiers (support vector machine with linear kernel (SVM-L), MLP-based neural network, AdaBoost, stochastic gradient descent and decision tree); and five types of training protocols (K2, K4, K5, K10 and JK). Using the decreasing order of MRR, our ML system demonstrates the mean classification accuracies as: 70.13 ± 0.15%, 87.34 ± 0.06%, 93.73 ± 0.03%, 94.45 ± 0.03% and 97.83 ± 0.01%, respectively, using all the classifiers and protocols. The corresponding AUC is 0.98 for SMS data using Multi-Layer Perceptron (MLP) based neural network. All the classifiers, the best accuracy of 91.84 ± 0.04% is shown to be of MLP-based neural network and this is 6% better over previously published. Further we observed that as MRR decreases, the system robustness increases and validated by standard deviations. The overall text system accuracy using all data types, classifiers, protocols is 89%, thereby showing the entire ML system to be novel, robust and unique. The system is also tested for stability and reliability.

Exploring the Solid Rocket Boosters and Properties of Matter

NASA Technical Reports Server (NTRS)

Moffett, Amy

2007-01-01

I worked for the United Space Alliance, LLC (USA) with the Solid Rocket Booster (SRB) Materials and Process engineers (M&P). I was assigned a project in which I needed to research and collect chemical and physical properties information, material safety data sheets (MSDS), and other product information from the vendor's websites and existing "inhouse" files for a select group of materials used in building and refurbishing the SRBs. This information was then compiled in a report that summarized the information collected. My work site was at the Kennedy Space Center (KSC). This allowed for many opportunities to visit and tour sites operated by NASA, by USA, and by the Air Force. This included the vehicle assembly building (VAB), orbital processing facilities (OPF), the crawler with the mobile launch pad (MLP), and the SRB assembly and refurbishment facility (ARF), to name a few. In addition, the launch, of STS- 117 took place within the first week of employment allowing a day by day following of that mission including post flight operations for the SRBs. Two Delta II rockets were also launched during these 7 weeks. The sights were incredible and the operations witnessed were amazing. I learned so many things I never knew about the entire program and the shuttle itself. The entire experience, especially my work with the SRB materials, inspired my plan for implementation into the classroom.

Visual classification of medical data using MLP mapping.

PubMed

Cağatay Güler, E; Sankur, B; Kahya, Y P; Raudys, S

1998-05-01

In this work we discuss the design of a novel non-linear mapping method for visual classification based on multilayer perceptrons (MLP) and assigned class target values. In training the perceptron, one or more target output values for each class in a 2-dimensional space are used. In other words, class membership information is interpreted visually as closeness to target values in a 2D feature space. This mapping is obtained by training the multilayer perceptron (MLP) using class membership information, input data and judiciously chosen target values. Weights are estimated in such a way that each training feature of the corresponding class is forced to be mapped onto the corresponding 2-dimensional target value.

Neural-network classifiers for automatic real-world aerial image recognition

NASA Astrophysics Data System (ADS)

Greenberg, Shlomo; Guterman, Hugo

1996-08-01

We describe the application of the multilayer perceptron (MLP) network and a version of the adaptive resonance theory version 2-A (ART 2-A) network to the problem of automatic aerial image recognition (AAIR). The classification of aerial images, independent of their positions and orientations, is required for automatic tracking and target recognition. Invariance is achieved by the use of different invariant feature spaces in combination with supervised and unsupervised neural networks. The performance of neural-network-based classifiers in conjunction with several types of invariant AAIR global features, such as the Fourier-transform space, Zernike moments, central moments, and polar transforms, are examined. The advantages of this approach are discussed. The performance of the MLP network is compared with that of a classical correlator. The MLP neural-network correlator outperformed the binary phase-only filter (BPOF) correlator. It was found that the ART 2-A distinguished itself with its speed and its low number of required training vectors. However, only the MLP classifier was able to deal with a combination of shift and rotation geometric distortions.

Neural-network classifiers for automatic real-world aerial image recognition.

PubMed

Greenberg, S; Guterman, H

1996-08-10

We describe the application of the multilayer perceptron (MLP) network and a version of the adaptive resonance theory version 2-A (ART 2-A) network to the problem of automatic aerial image recognition (AAIR). The classification of aerial images, independent of their positions and orientations, is required for automatic tracking and target recognition. Invariance is achieved by the use of different invariant feature spaces in combination with supervised and unsupervised neural networks. The performance of neural-network-based classifiers in conjunction with several types of invariant AAIR global features, such as the Fourier-transform space, Zernike moments, central moments, and polar transforms, are examined. The advantages of this approach are discussed. The performance of the MLP network is compared with that of a classical correlator. The MLP neural-network correlator outperformed the binary phase-only filter (BPOF) correlator. It was found that the ART 2-A distinguished itself with its speed and its low number of required training vectors. However, only the MLP classifier was able to deal with a combination of shift and rotation geometric distortions.

Increased Migration of Monocytes in Essential Hypertension Is Associated with Increased Transient Receptor Potential Channel Canonical Type 3 Channels

PubMed Central

Chen, Jing; Zhong, Jian; Yu, Hao; Xu, Xingsen; He, Hongbo; Yan, Zhencheng; Scholze, Alexandra; Liu, Daoyan; Zhu, Zhiming; Tepel, Martin

2012-01-01

Increased transient receptor potential canonical type 3 (TRPC3) channels have been observed in patients with essential hypertension. In the present study we tested the hypothesis that increased monocyte migration is associated with increased TRPC3 expression. Monocyte migration assay was performed in a microchemotaxis chamber using chemoattractants formylated peptide Met-Leu-Phe (fMLP) and tumor necrosis factor-α (TNF-α). Proteins were identified by immunoblotting and quantitative in-cell Western assay. The effects of TRP channel-inhibitor 2–aminoethoxydiphenylborane (2-APB) and small interfering RNA knockdown of TRPC3 were investigated. We observed an increased fMLP-induced migration of monocytes from hypertensive patients compared with normotensive control subjects (246±14% vs 151±10%). The TNF-α-induced migration of monocytes in patients with essential hypertension was also significantly increased compared to normotensive control subjects (221±20% vs 138±18%). In the presence of 2-APB or after siRNA knockdown of TRPC3 the fMLP-induced monocyte migration was significantly blocked. The fMLP-induced changes of cytosolic calcium were significantly increased in monocytes from hypertensive patients compared to normotensive control subjects. The fMLP-induced monocyte migration was significantly reduced in the presence of inhibitors of tyrosine kinase and phosphoinositide 3-kinase. We conclude that increased monocyte migration in patients with essential hypertension is associated with increased TRPC3 channels. PMID:22438881

A deep auto-encoder model for gene expression prediction.

PubMed

Xie, Rui; Wen, Jia; Quitadamo, Andrew; Cheng, Jianlin; Shi, Xinghua

2017-11-17

Gene expression is a key intermediate level that genotypes lead to a particular trait. Gene expression is affected by various factors including genotypes of genetic variants. With an aim of delineating the genetic impact on gene expression, we build a deep auto-encoder model to assess how good genetic variants will contribute to gene expression changes. This new deep learning model is a regression-based predictive model based on the MultiLayer Perceptron and Stacked Denoising Auto-encoder (MLP-SAE). The model is trained using a stacked denoising auto-encoder for feature selection and a multilayer perceptron framework for backpropagation. We further improve the model by introducing dropout to prevent overfitting and improve performance. To demonstrate the usage of this model, we apply MLP-SAE to a real genomic datasets with genotypes and gene expression profiles measured in yeast. Our results show that the MLP-SAE model with dropout outperforms other models including Lasso, Random Forests and the MLP-SAE model without dropout. Using the MLP-SAE model with dropout, we show that gene expression quantifications predicted by the model solely based on genotypes, align well with true gene expression patterns. We provide a deep auto-encoder model for predicting gene expression from SNP genotypes. This study demonstrates that deep learning is appropriate for tackling another genomic problem, i.e., building predictive models to understand genotypes' contribution to gene expression. With the emerging availability of richer genomic data, we anticipate that deep learning models play a bigger role in modeling and interpreting genomics.

Artificial neural network for suppression of banding artifacts in balanced steady-state free precession MRI.

PubMed

Kim, Ki Hwan; Park, Sung-Hong

2017-04-01

The balanced steady-state free precession (bSSFP) MR sequence is frequently used in clinics, but is sensitive to off-resonance effects, which can cause banding artifacts. Often multiple bSSFP datasets are acquired at different phase cycling (PC) angles and then combined in a special way for banding artifact suppression. Many strategies of combining the datasets have been suggested for banding artifact suppression, but there are still limitations in their performance, especially when the number of phase-cycled bSSFP datasets is small. The purpose of this study is to develop a learning-based model to combine the multiple phase-cycled bSSFP datasets for better banding artifact suppression. Multilayer perceptron (MLP) is a feedforward artificial neural network consisting of three layers of input, hidden, and output layers. MLP models were trained by input bSSFP datasets acquired from human brain and knee at 3T, which were separately performed for two and four PC angles. Banding-free bSSFP images were generated by maximum-intensity projection (MIP) of 8 or 12 phase-cycled datasets and were used as targets for training the output layer. The trained MLP models were applied to another brain and knee datasets acquired with different scan parameters and also to multiple phase-cycled bSSFP functional MRI datasets acquired on rat brain at 9.4T, in comparison with the conventional MIP method. Simulations were also performed to validate the MLP approach. Both the simulations and human experiments demonstrated that MLP suppressed banding artifacts significantly, superior to MIP in both banding artifact suppression and SNR efficiency. MLP demonstrated superior performance over MIP for the 9.4T fMRI data as well, which was not used for training the models, while visually preserving the fMRI maps very well. Artificial neural network is a promising technique for combining multiple phase-cycled bSSFP datasets for banding artifact suppression. Copyright © 2016 Elsevier Inc. All rights reserved.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines nears the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be delivered to the VAB, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines is being prepared for the move into the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platform was transported from fabricator Met-Con Inc. in Cocoa, Florida. It will be stored in the VAB, and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines backs up inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines backs in to the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines arrives inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines arrives at the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

New service platforms for NASA's Space Launch System booster engines, secured on two flatbed trucks, are on their way to the agency's Kennedy Space Center in Florida. They are being transported from fabricator Met-Con Inc. in Cocoa, Florida. The platforms will be delivered to the Vehicle Assembly Building, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

One of two new work platforms for NASA's Space Launch System booster engines is secured on dunnage inside the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be stored in the VAB, where they will be used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

KSC-08pd1244

NASA Image and Video Library

2008-05-02

CAPE CANAVERAL, Fla. -- Artist's rendering of the empty Constellation Program's mobile launcher platform planned for the Ares I rocket. The tower of the mobile launcher will have multiple platforms for personnel access and will be approximately 390 feet tall. The tower will be used in the assembly, testing and servicing of the Ares rockets at Kennedy and will also transport the Ares rockets to the launch pad and provide ground support for launches.

KSC-08pd1245

NASA Image and Video Library

2008-05-02

CAPE CANAVERAL, Fla. -- Artist's rendering of the Constellation Program's mobile launcher platform with an Ares I rocket attached. The tower of the mobile launcher will have multiple platforms for personnel access and will be approximately 390 feet tall. The tower will be used in the assembly, testing and servicing of the Ares rockets at Kennedy and will also transport the Ares rockets to the launch pad and provide ground support for launches.

Surrounded by work platforms, the full-scale Orion AFT crew module (center) is undergoing preparations for the first flight test of Orion's launch abort system.

NASA Image and Video Library

2008-05-20

Surrounded by work platforms, NASA's first full-scale Orion abort flight test (AFT) crew module (center) is undergoing preparations at the NASA Dryden Flight Research Center in California for the first flight test of Orion's launch abort system. To the left is a space shuttle orbiter purge vehicle sharing the hangar.

The use of tethers for payload orbital transfer. Continuation of investigation of electrodynamic stabilization and control of long orbiting tethers, volume 2

NASA Technical Reports Server (NTRS)

Colombo, G.; Martinez-Sanchez, M.; Arnold, D.

1982-01-01

The SKYHOOK program was used to do simulations of two cases of the use of the tether for payload orbital transfer. The transport of a payload along the tether from a heavy lower platform to an upper launching platform is considered. A numerical example of the Shuttle launching a payload using an orbital tether facility is described.

Negative correlation learning for customer churn prediction: a comparison study.

PubMed

Rodan, Ali; Fayyoumi, Ayham; Faris, Hossam; Alsakran, Jamal; Al-Kadi, Omar

2015-01-01

Recently, telecommunication companies have been paying more attention toward the problem of identification of customer churn behavior. In business, it is well known for service providers that attracting new customers is much more expensive than retaining existing ones. Therefore, adopting accurate models that are able to predict customer churn can effectively help in customer retention campaigns and maximizing the profit. In this paper we will utilize an ensemble of Multilayer perceptrons (MLP) whose training is obtained using negative correlation learning (NCL) for predicting customer churn in a telecommunication company. Experiments results confirm that NCL based MLP ensemble can achieve better generalization performance (high churn rate) compared with ensemble of MLP without NCL (flat ensemble) and other common data mining techniques used for churn analysis.

Extended Malus Law with metallic linear polarizers in terahertz and microwave domains

NASA Astrophysics Data System (ADS)

Romain, Xavier; Baida, Fadi; Boyer, Philippe

2016-04-01

An extended Malus' Law for the well-known Polarizer-Analyzer Mounting (PAM) is analytically obtained and investigated. The PAM is composed of two perfectly parallel Metallic Linear Polarizers (MLP), with subwavelength periodic pattern composed of rectangular holes. Our analytical theory especially highlights the influence of multiple reflections between the two MLPs which leads to an extended and tunable Malus Law. We demonstrate that the classical Malus Law (obtained for dichroic polarizers) is modulated by a factor which also depends on the angular difference between both MLP axes. In our analysis, the Malus' law is studied at the resonance wavelengths. Due to the interactions between the two MLP, the modulation factor is tuned by the optical distance between them which makes substantial variations of the Malus Law. We mention that, for each reflections, the light is re-polarized according to the orientation of the MLP. This tunable Malus' Law provides an original tool for ultrasensitive detection in the terahertz or microwave regime. For example, one can use an ultra-narrow angle Malus' Law as a hyper-sensitive device to analyze with a high accuracy the electro-optical response of a material sandwiched between polarizer and analyzer. We theoretically propose one PAM designed to detect a refractive index variation as small as 10-5. Finally, we extend the theory, which takes the form of an extended Jones formalism, to a large number of stacked MLP. It is applied to achieve many polarization manipulation processes as total polarization conversion with tunable spectral bandwidth, for instance.

In vivo epicardial force and strain characterisation in normal and MLP-knockout murine hearts.

PubMed

Michaelides, M; Georgiadou, S; Constantinides, C

2015-07-01

The study's objective is to quantify in vivo epicardial force and strain in the normal and transgenic myocardium using microsensors.Male mice (n = 39), including C57BL/6 (n = 26), 129/Sv (n = 5), wild-type (WT) C57  ×  129Sv (n = 5), and muscle LIM protein (MLP) knock-out (n = 3), were studied under 1.5% isoflurane anaesthesia. Microsurgery allowed the placement of two piezoelectric crystals at longitudinal epicardial loci at the basal, middle, and apical LV regions, and the independent (and/or concurrent) placement of a cantilever force sensor. The findings demonstrate longitudinal contractile and relaxation strains that ranged between 4.8-9.3% in the basal, middle, and apical regions of C57BL/6 mice, and in the mid-ventricular regions of 129/Sv, WT, and MLP mice. Measured forces ranged between 3.1-8.9 mN. The technique's feasibility is also demonstrated in normal mice following afterload, occlusion-reperfusion challenges.Furthermore, the total mid-ventricular forces developed in MLP mice were significantly reduced compared to the WT controls (5.9  ±  0.4 versus 8.9  ±  0.2 mN, p < 0.0001), possibly owing to the fibrotic and stiffer myocardium. No significant strain differences were noted between WT and MLP mice.The possibility of quantifying in vivo force and strain from the normal murine heart is demonstrated with a potential usefulness in the characterisation of transgenic and diseased mice, where regional myocardial function may be significantly altered.

KENNEDY SPACE CENTER, FLA. - Workers, covered in protective clothing and breathing apparatus, continue sandblasting on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - Workers, covered in protective clothing and breathing apparatus, continue sandblasting on the Mobile Launcher Platform on Launch Pad 39A to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

KENNEDY SPACE CENTER, FLA. - On Launch Pad 39A, clouds of dust float away from the Mobile Launcher Platform, which is undergoing sandblasting to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

NASA Image and Video Library

2003-09-12

KENNEDY SPACE CENTER, FLA. - On Launch Pad 39A, clouds of dust float away from the Mobile Launcher Platform, which is undergoing sandblasting to remove corrosion before repainting. Routine maintenance includes sandblasting and repainting as preventive means to minimize corrosion.

The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding.

PubMed

Lan, Susan; Kamel, Wael; Punga, Tanel; Akusjärvi, Göran

2017-02-28

The adenovirus L4-22K protein both activates and suppresses transcription from the adenovirus major late promoter (MLP) by binding to DNA elements located downstream of the MLP transcriptional start site: the so-called DE element (positive) and the R1 region (negative). Here we show that L4-22K preferentially binds to the RNA form of the R1 region, both to the double-stranded RNA and the single-stranded RNA of the same polarity as the nascent MLP transcript. Further, L4-22K binds to a 5΄-CAAA-3΄ motif in the single-stranded RNA, which is identical to the sequence motif characterized for L4-22K DNA binding. L4-22K binding to single-stranded RNA results in an enhancement of U1 snRNA recruitment to the major late first leader 5΄ splice site. This increase in U1 snRNA binding results in a suppression of MLP transcription and a concurrent stimulation of major late first intron splicing. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Performance evaluation of MLP and RBF feed forward neural network for the recognition of off-line handwritten characters

NASA Astrophysics Data System (ADS)

Rishi, Rahul; Choudhary, Amit; Singh, Ravinder; Dhaka, Vijaypal Singh; Ahlawat, Savita; Rao, Mukta

2010-02-01

In this paper we propose a system for classification problem of handwritten text. The system is composed of preprocessing module, supervised learning module and recognition module on a very broad level. The preprocessing module digitizes the documents and extracts features (tangent values) for each character. The radial basis function network is used in the learning and recognition modules. The objective is to analyze and improve the performance of Multi Layer Perceptron (MLP) using RBF transfer functions over Logarithmic Sigmoid Function. The results of 35 experiments indicate that the Feed Forward MLP performs accurately and exhaustively with RBF. With the change in weight update mechanism and feature-drawn preprocessing module, the proposed system is competent with good recognition show.

Negative Correlation Learning for Customer Churn Prediction: A Comparison Study

PubMed Central

Faris, Hossam

2015-01-01

Recently, telecommunication companies have been paying more attention toward the problem of identification of customer churn behavior. In business, it is well known for service providers that attracting new customers is much more expensive than retaining existing ones. Therefore, adopting accurate models that are able to predict customer churn can effectively help in customer retention campaigns and maximizing the profit. In this paper we will utilize an ensemble of Multilayer perceptrons (MLP) whose training is obtained using negative correlation learning (NCL) for predicting customer churn in a telecommunication company. Experiments results confirm that NCL based MLP ensemble can achieve better generalization performance (high churn rate) compared with ensemble of MLP without NCL (flat ensemble) and other common data mining techniques used for churn analysis. PMID:25879060

A nonlinear discriminant algorithm for feature extraction and data classification.

PubMed

Santa Cruz, C; Dorronsoro, J R

1998-01-01

This paper presents a nonlinear supervised feature extraction algorithm that combines Fisher's criterion function with a preliminary perceptron-like nonlinear projection of vectors in pattern space. Its main motivation is to combine the approximation properties of multilayer perceptrons (MLP's) with the target free nature of Fisher's classical discriminant analysis. In fact, although MLP's provide good classifiers for many problems, there may be some situations, such as unequal class sizes with a high degree of pattern mixing among them, that may make difficult the construction of good MLP classifiers. In these instances, the features extracted by our procedure could be more effective. After the description of its construction and the analysis of its complexity, we will illustrate its use over a synthetic problem with the above characteristics.

Towards Flange-to-Flange Turbopump Simulations for Liquid Rocket Engines

NASA Technical Reports Server (NTRS)

Kiris, Cetin; Williams, Robert

2000-01-01

The primary objective of this research is to support the design of liquid rocket systems for the Advanced Space Transportation System. Since the space launch systems in the near future are likely to rely on liquid rocket engines, increasing the efficiency and reliability of the engine components is an important task. One of the major problems in the liquid rocket engine is to understand fluid dynamics of fuel and oxidizer flows from the fuel tank to plume. Understanding the flow through the entire turbopump geometry through numerical simulation will be of significant value toward design. This will help to improve safety of future space missions. One of the milestones of this effort is to develop, apply and demonstrate the capability and accuracy of 3D CFD methods as efficient design analysis tools on high performance computer platforms. The development of the MPI and MLP versions of the INS3D code is currently underway. The serial version of INS3D code is a multidimensional incompressible Navier-Stokes solver based on overset grid technology. INS3D-MPI is based on the explicit massage-passing interface across processors and is primarily suited for distributed memory systems. INS3D-MLP is based on multi-level parallel method and is suitable for distributed-shared memory systems. For the entire turbopump simulations, moving boundary capability and an efficient time-accurate integration methods are build in the flow solver. To handle the geometric complexity and moving boundary problems, overset grid scheme is incorporated with the solver that new connectivity data will be obtained at each time step. The Chimera overlapped grid scheme allows subdomains move relative to each other, and provides a great flexibility when the boundary movement creates large displacements. The performance of the two time integration schemes for time-accurate computations is investigated. For an unsteady flow which requires small physical time step, the pressure projection method was found to be computationally efficient since it does not require any subiterations procedure. It was observed that the artificial compressibility method requires a fast convergence scheme at each physical time step in order to satisfy incompressibility condition. This was obtained by using a GMRES-ILU(0) solver in our computations. When a line-relaxation scheme was used, the time accuracy was degraded and time-accurate computations became very expensive. The current geometry for the LOX boost turbopump has various rotating and stationary components, such as inducer, stators, kicker, hydrolic turbine, where the flow is extremely unsteady. Figure 1 shows the geometry and computed surface pressure of the inducer. The inducer and the hydrolic turbine rotate in different rotational speed.

Developmental Testing of Electric Thrust Vector Control Systems for Manned Launch Vehicle Applications

NASA Technical Reports Server (NTRS)

Bates, Lisa B.; Young, David T.

2012-01-01

This paper describes recent developmental testing to verify the integration of a developmental electromechanical actuator (EMA) with high rate lithium ion batteries and a cross platform extensible controller. Testing was performed at the Thrust Vector Control Research, Development and Qualification Laboratory at the NASA George C. Marshall Space Flight Center. Electric Thrust Vector Control (ETVC) systems like the EMA may significantly reduce recurring launch costs and complexity compared to heritage systems. Electric actuator mechanisms and control requirements across dissimilar platforms are also discussed with a focus on the similarities leveraged and differences overcome by the cross platform extensible common controller architecture.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, has arrived at the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be stored in the VAB and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines has been offloaded from a flatbed truck and is being prepared for the move into the Vehicle Assembly Building (VAB) at the agency's Kennedy Space Center in Florida. The platform was transported from fabricator Met-Con Inc. in Cocoa, Florida. It will be stored in the VAB, and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, is on its way to the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be delivered to the Vehicle Assembly Building, where it will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

SLS Booster Engine Service Platforms Delivery

NASA Image and Video Library

2017-07-31

A flatbed truck carrying one of two new service platforms for NASA's Space Launch System booster engines makes its way along the NASA Causeway to the agency's Kennedy Space Center in Florida. The platforms were transported from fabricator Met-Con Inc. in Cocoa, Florida. They will be delivered to the Vehicle Assembly Building, where they will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1. EM-1 will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon and bring it back to Earth for a splashdown in the Pacific Ocean.

Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring

PubMed Central

Mahadevan, Sangeetha K.; Fiorotto, Marta L.; Van den Veyver, Ignatia B.

2017-01-01

Offspring of murine dams chronically fed a protein-restricted diet have an increased risk for metabolic and neurobehavioral disorders. Previously we showed that adult offspring, developmentally exposed to a chronic maternal low-protein (MLP) diet, had lower body and hind-leg muscle weights and decreased liver enzyme serum levels. We conducted energy expenditure, neurobehavioral and circadian rhythm assays in male offspring to examine mechanisms for the body-weight phenotype and assess neurodevelopmental implications of MLP exposure. C57BL/6J dams were fed a protein restricted (8%protein, MLP) or a control protein (20% protein, C) diet from four weeks before mating until weaning of offspring. Male offspring were weaned to standard rodent diet (20% protein) and single-housed until 8–12 weeks of age. We examined body composition, food intake, energy expenditure, spontaneous rearing activity and sleep patterns and performed behavioral assays for anxiety (open field activity, elevated plus maze [EPM], light/dark exploration), depression (tail suspension and forced swim test), sociability (three-chamber), repetitive (marble burying), learning and memory (fear conditioning), and circadian behavior (wheel-running activity during light-dark and constant dark cycles). We also measured circadian gene expression in hypothalamus and liver at different Zeitgeber times (ZT). Male offspring from separate MLP exposed dams had significantly greater body fat (P = 0.03), less energy expenditure (P = 0.004), less rearing activity (P = 0.04) and a greater number of night-time rest/sleep bouts (P = 0.03) compared to control. MLP offspring displayed greater anxiety-like behavior in the EPM (P<0.01) but had no learning and memory deficit in fear-conditioning assay (P = 0.02). There was an effect of time on Per1, Per 2 and Clock circadian gene expression in the hypothalamus but not on circadian behavior. Thus, transplacental and early developmental exposure of dams to chronic MLP reduces food intake and energy expenditure, increases anxiety like behavior and disturbs sleep patterns but not circadian rhythm in adult male offspring. PMID:28099477

VIEW OF HB1 (VAB HIGH BAY) WITH MOBILE LAUNCHER PLATFORM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF HB-1 (VAB HIGH BAY) WITH MOBILE LAUNCHER PLATFORM (VEHICLE ACCESS PLATFORMS ARE VISIBLE IN THE CENTER), FACING WEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Pegasus air-launched space booster

NASA Astrophysics Data System (ADS)

Lindberg, Robert E.; Mosier, Marty R.

The launching of small satellites with the mother- aircraft-launched Pegasus booster yields substantial cost improvements over ground launching and enhances operational flexibility, since it allows launches to be conducted into any orbital inclination. The Pegasus launch vehicle is a three-stage solid-rocket-propelled system with delta-winged first stage. The major components of airborne support equipment, located on the mother aircraft, encompass a launch panel operator console, an electronic pallet, and a pylon adapter. Alternatives to the currently employed B-52 launch platform aircraft have been identified for future use. Attention is given to the dynamic, thermal, and acoustic environments experienced by the payload.

New consensus multivariate models based on PLS and ANN studies of sigma-1 receptor antagonists.

PubMed

Oliveira, Aline A; Lipinski, Célio F; Pereira, Estevão B; Honorio, Kathia M; Oliveira, Patrícia R; Weber, Karen C; Romero, Roseli A F; de Sousa, Alexsandro G; da Silva, Albérico B F

2017-10-02

The treatment of neuropathic pain is very complex and there are few drugs approved for this purpose. Among the studied compounds in the literature, sigma-1 receptor antagonists have shown to be promising. In order to develop QSAR studies applied to the compounds of 1-arylpyrazole derivatives, multivariate analyses have been performed in this work using partial least square (PLS) and artificial neural network (ANN) methods. A PLS model has been obtained and validated with 45 compounds in the training set and 13 compounds in the test set (r 2 training = 0.761, q 2 = 0.656, r 2 test = 0.746, MSE test = 0.132 and MAE test = 0.258). Additionally, multi-layer perceptron ANNs (MLP-ANNs) were employed in order to propose non-linear models trained by gradient descent with momentum backpropagation function. Based on MSE test values, the best MLP-ANN models were combined in a MLP-ANN consensus model (MLP-ANN-CM; r 2 test = 0.824, MSE test = 0.088 and MAE test = 0.197). In the end, a general consensus model (GCM) has been obtained using PLS and MLP-ANN-CM models (r 2 test = 0.811, MSE test = 0.100 and MAE test = 0.218). Besides, the selected descriptors (GGI6, Mor23m, SRW06, H7m, MLOGP, and μ) revealed important features that should be considered when one is planning new compounds of the 1-arylpyrazole class. The multivariate models proposed in this work are definitely a powerful tool for the rational drug design of new compounds for neuropathic pain treatment. Graphical abstract Main scaffold of the 1-arylpyrazole derivatives and the selected descriptors.

Magic Learning Pill: Ontological and Instrumental Learning in Order to Speed Up Education.

PubMed

Matusov, Eugene; Baker, Daniella; Fan, Yueyue; Choi, Hye Jung; L Hampel, Robert

2017-09-01

The purpose of this research is to investigate the phenomenology of learning - people"s attitudes toward their learning experiences that have inherent worth in themselves (i.e., ontological learning) or have value outside of the learning itself (i.e., instrumental learning). In order to explore this topic, 58 participants from the U.S., Russia, and Brazil were interviewed with a central question derived from the science fiction writer Isaac Asimov's short story "Profession": whether participants would take a "Magic Learning Pill" (MLP) to avoid the process of learning, and instead magically acquire the knowledge. The MLP would guarantee the immediate learning by skipping the process of learning while achieving the same effect of gaining skills and knowledge. Almost all participants could think of some learning experiences for which they would take MLP and others for which they would not. Many participants would not take MLP for ontological learning, which is learning experiences that have inherent value for the people, while they would take MLP for instrumental learning, which is learning that mainly serves some other non-educational purposes. The main finding suggests that both instrumental and ontological types of learning are recognized by a wide range of people from diverse cultures as present and valued in their lives. This is especially significant in light of the overwhelmingly instrumental tone of public discourse about education. In the context of formal education, ontological learning was mentioned 35 times (28.0%) while instrumental learning was mentioned 74 times (60.2%). Although ontological learning was often mentioned as taking place outside of school, incorporating pedagogy supporting ontological learning at school deserves consideration.

Drug targeted virtual screening and molecular dynamics of LipU protein of Mycobacterium tuberculosis and Mycobacterium leprae.

PubMed

Kaur, Gurkamaljit; Pandey, Bharati; Grover, Arbind; Garewal, Naina; Grover, Abhinav; Kaur, Jagdeep

2018-03-30

The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. leprae (MLP LipU). The MTB LipU was identified in extracellular fraction and was reported to be essential for the survival of mycobacterium. Therefore to address the problem of drug resistance in pathogen, LipU was selected as a drug target and the viability of finding out some FDA approved drugs as LipU inhibitors in both the cases was explored. Three-dimensional (3D) model structures of MTB LipU and MLP LipU were generated and stabilized through molecular dynamics (MD). FDA approved drugs were screened against these proteins. The result showed that the top-scoring compounds for MTB LipU were Diosmin, Acarbose and Ouabain with the Glide XP score of -12.8, -11.9 and -11.7 kcal/mol, respectively, whereas for MLP LipU protein, Digoxin (-9.2 kcal/mol), Indinavir (-8.2 kcal/mol) and Travoprost (-8.2 kcal/mol) showed highest affinity. These drugs remained bound in the active site pocket of MTB LipU and MLP LipU structure and interaction grew stronger after dynamics. RMSD, RMSF and Rg were found to be persistent throughout the simulation period. Hydrogen bonds along with large number of hydrophobic interactions stabilized the complex structures. Binding free energies obtained through Prime/MM-GBSA were found in the significant range from -63.85 kcal/mol to -34.57 kcal/mol for MTB LipU and -71.33 kcal/mol to -23.91 kcal/mol for MLP LipU. The report suggested high probability of these drugs to demolish the LipU activity and could be probable drug candidates to combat TB and leprosy disease.

Laying the Groundwork for Enterprise-Wide Medical Language Processing Services: Architecture and Process

PubMed Central

Chen, Elizabeth S.; Maloney, Francine L.; Shilmayster, Eugene; Goldberg, Howard S.

2009-01-01

A systematic and standard process for capturing information within free-text clinical documents could facilitate opportunities for improving quality and safety of patient care, enhancing decision support, and advancing data warehousing across an enterprise setting. At Partners HealthCare System, the Medical Language Processing (MLP) services project was initiated to establish a component-based architectural model and processes to facilitate putting MLP functionality into production for enterprise consumption, promote sharing of components, and encourage reuse. Key objectives included exploring the use of an open-source framework called the Unstructured Information Management Architecture (UIMA) and leveraging existing MLP-related efforts, terminology, and document standards. This paper describes early experiences in defining the infrastructure and standards for extracting, encoding, and structuring clinical observations from a variety of clinical documents to serve enterprise-wide needs. PMID:20351830

Laying the groundwork for enterprise-wide medical language processing services: architecture and process.

PubMed

Chen, Elizabeth S; Maloney, Francine L; Shilmayster, Eugene; Goldberg, Howard S

2009-11-14

A systematic and standard process for capturing information within free-text clinical documents could facilitate opportunities for improving quality and safety of patient care, enhancing decision support, and advancing data warehousing across an enterprise setting. At Partners HealthCare System, the Medical Language Processing (MLP) services project was initiated to establish a component-based architectural model and processes to facilitate putting MLP functionality into production for enterprise consumption, promote sharing of components, and encourage reuse. Key objectives included exploring the use of an open-source framework called the Unstructured Information Management Architecture (UIMA) and leveraging existing MLP-related efforts, terminology, and document standards. This paper describes early experiences in defining the infrastructure and standards for extracting, encoding, and structuring clinical observations from a variety of clinical documents to serve enterprise-wide needs.

A new approach for categorizing pig lying behaviour based on a Delaunay triangulation method.

PubMed

Nasirahmadi, A; Hensel, O; Edwards, S A; Sturm, B

2017-01-01

Machine vision-based monitoring of pig lying behaviour is a fast and non-intrusive approach that could be used to improve animal health and welfare. Four pens with 22 pigs in each were selected at a commercial pig farm and monitored for 15 days using top view cameras. Three thermal categories were selected relative to room setpoint temperature. An image processing technique based on Delaunay triangulation (DT) was utilized. Different lying patterns (close, normal and far) were defined regarding the perimeter of each DT triangle and the percentages of each lying pattern were obtained in each thermal category. A method using a multilayer perceptron (MLP) neural network, to automatically classify group lying behaviour of pigs into three thermal categories, was developed and tested for its feasibility. The DT features (mean value of perimeters, maximum and minimum length of sides of triangles) were calculated as inputs for the MLP classifier. The network was trained, validated and tested and the results revealed that MLP could classify lying features into the three thermal categories with high overall accuracy (95.6%). The technique indicates that a combination of image processing, MLP classification and mathematical modelling can be used as a precise method for quantifying pig lying behaviour in welfare investigations.

Booster Engine Service Platforms Delivered to VAB

NASA Image and Video Library

2018-04-17

A new service platform for NASA's Space Launch System booster engines, secured on a flatbed truck, is on its way to the Vehicle Assembly Building (VAB), in view in the distance, at the agency's Kennedy Space Center in Florida. It was transported from fabricator Met-Con Inc. in Cocoa, Florida. The platform will be delivered to the VAB, where it will be stored and used for processing and checkout of the engines for the rocket's twin five-segment solid rocket boosters for Exploration Mission-1 (EM-1). During EM-1, an uncrewed Orion spacecraft will launch on the SLS to a stable orbit beyond the Moon and return to Earth for a splashdown in the Pacific Ocean.

San Marco D/L Explorer

NASA Technical Reports Server (NTRS)

1988-01-01

ti March 26, 1964, Centro Ricerche Aerospaziali (CRA) successfully launched a two-stage Nike sounding rocket from the Santa Rita launch platform off the Kenya coast, concluding Phase I. It carried basic elements of the San Marco science instrumentation and served further to flight qualify these canponents as well as provide a means of check-out of range instrumentation and equipment. The second phase culminated in the launch of the San Marco-I Spacecraft fran Wallops Island on a Scout vehicle on December 15, 1964. This launch derronstrated the readiness of the CRA launch crews for Phase III operations and qualified the basic spacecraft design. In addition it confirmed the usefulness and reliability of the drag balance device for accurate determinations of air density values and satellite attitude. phase III was completed with the launching of San Marco-11 frcm the San Marco platform off the coast of Kenya on April 26, 1967. ?he San Marco-II carried the same instrunentation as the San Marco-I, but the equatorial orbit permitted a more detailed study to be made of density variations versus altitude in the equatorial region. Ihe successful launch also served to qualify the San Marco Range as a reliable facility for future satellite launches. The successful culmination of the first San Marco endeavor paved the way for still closer collaboration in future space explorations.

Development of Test Article Building Block (TABB) for deployable platform systems

NASA Technical Reports Server (NTRS)

Greenberg, H. S.; Barbour, R. T.

1984-01-01

The concept of a Test Article Building Block (TABB) is described. The TABB is a ground test article that is representative of a future building block that can be used to construct LEO and GEO deployable space platforms for communications and scientific payloads. This building block contains a main housing within which the entire structure, utilities, and deployment/retraction mechanism are stowed during launch. The end adapter secures the foregoing components to the housing during launch. The main housing and adapter provide the necessary building-block-to-building-block attachments for automatically deployable platforms. Removal from the shuttle cargo bay can be accomplished with the remote manipulator system (RMS) and/or the handling and positioning aid (HAPA). In this concept, all the electrical connections are in place prior to launch with automatic latches for payload attachment provided on either the end adapters or housings. The housings also can contain orbiter docking ports for payload installation and maintenance.

Advanced Propulsion for Gun Launched Projectiles and Missiles: Phase 1 - Low Cost Flight Test Platform Development

DTIC Science & Technology

2009-11-30

Son blueberry fields as shown in Figure 113. All FAA and Maine DOT permits were acquired. Richard Willey was the designated LSO (Launch Safety...The launch area is on the Jasper Wyman & Son blueberry fields as shown in Figure 113. FAA and Maine DOT permits are required for flight testing

Modeling of autocatalytic hydrolysis of adefovir dipivoxil in solid formulations.

PubMed

Dong, Ying; Zhang, Yan; Xiang, Bingren; Deng, Haishan; Wu, Jingfang

2011-04-01

The stability and hydrolysis kinetics of a phosphate prodrug, adefovir dipivoxil, in solid formulations were studied. The stability relationship between five solid formulations was explored. An autocatalytic mechanism for hydrolysis could be proposed according to the kinetic behavior which fits the Prout-Tompkins model well. For the classical kinetic models could hardly describe and predict the hydrolysis kinetics of adefovir dipivoxil in solid formulations accurately when the temperature is high, a feedforward multilayer perceptron (MLP) neural network was constructed to model the hydrolysis kinetics. The build-in approaches in Weka, such as lazy classifiers and rule-based learners (IBk, KStar, DecisionTable and M5Rules), were used to verify the performance of MLP. The predictability of the models was evaluated by 10-fold cross-validation and an external test set. It reveals that MLP should be of general applicability proposing an alternative efficient way to model and predict autocatalytic hydrolysis kinetics for phosphate prodrugs.

Application of Multilayer Perceptron with Automatic Relevance Determination on Weed Mapping Using UAV Multispectral Imagery

PubMed Central

Tamouridou, Afroditi A.; Lagopodi, Anastasia L.; Kashefi, Javid; Kasampalis, Dimitris; Kontouris, Georgios; Moshou, Dimitrios

2017-01-01

Remote sensing techniques are routinely used in plant species discrimination and of weed mapping. In the presented work, successful Silybum marianum detection and mapping using multilayer neural networks is demonstrated. A multispectral camera (green-red-near infrared) attached on a fixed wing unmanned aerial vehicle (UAV) was utilized for the acquisition of high-resolution images (0.1 m resolution). The Multilayer Perceptron with Automatic Relevance Determination (MLP-ARD) was used to identify the S. marianum among other vegetation, mostly Avena sterilis L. The three spectral bands of Red, Green, Near Infrared (NIR) and the texture layer resulting from local variance were used as input. The S. marianum identification rates using MLP-ARD reached an accuracy of 99.54%. Τhe study had an one year duration, meaning that the results are specific, although the accuracy shows the interesting potential of S. marianum mapping with MLP-ARD on multispectral UAV imagery. PMID:29019957

MLP based LOGSIG transfer function for solar generation monitoring

NASA Astrophysics Data System (ADS)

Hashim, Fakroul Ridzuan; Din, Muhammad Faiz Md; Ahmad, Shahril; Arif, Farah Khairunnisa; Rizman, Zairi Ismael

2018-02-01

Solar panel is one of the renewable energy that can reduce the environmental pollution and have a wide potential of application. The exact solar prediction model will give a big impact on the management of solar power plants and the design of solar energy systems. This paper attempts to use Multilayer Perceptron (MLP) neural network based transfer function. The MLP network can be used to calculate the temperature module (TM) in Malaysia. This can be done by simulating the collected data of four weather variables which are the ambient temperature (TA), local wind speed (VW), solar radiation flux (GT) and the relative humidity (RH) as the input into the neural network. The transfer function will be applied to the 14 types of training. Finally, an equation from the best training algorithm will be deduced to calculate the temperature module based on the input of weather variables in Malaysia.

Application of Multilayer Perceptron with Automatic Relevance Determination on Weed Mapping Using UAV Multispectral Imagery.

PubMed

Tamouridou, Afroditi A; Alexandridis, Thomas K; Pantazi, Xanthoula E; Lagopodi, Anastasia L; Kashefi, Javid; Kasampalis, Dimitris; Kontouris, Georgios; Moshou, Dimitrios

2017-10-11

Remote sensing techniques are routinely used in plant species discrimination and of weed mapping. In the presented work, successful Silybum marianum detection and mapping using multilayer neural networks is demonstrated. A multispectral camera (green-red-near infrared) attached on a fixed wing unmanned aerial vehicle (UAV) was utilized for the acquisition of high-resolution images (0.1 m resolution). The Multilayer Perceptron with Automatic Relevance Determination (MLP-ARD) was used to identify the S. marianum among other vegetation, mostly Avena sterilis L. The three spectral bands of Red, Green, Near Infrared (NIR) and the texture layer resulting from local variance were used as input. The S. marianum identification rates using MLP-ARD reached an accuracy of 99.54%. Τhe study had an one year duration, meaning that the results are specific, although the accuracy shows the interesting potential of S. marianum mapping with MLP-ARD on multispectral UAV imagery.

Effectiveness of educational outreach in infectious diseases management: a cluster randomized trial in Uganda.

PubMed

Mbonye, Martin Kayitale; Burnett, Sarah M; Naikoba, Sarah; Ronald, Allan; Colebunders, Robert; Van Geertruyden, Jean-Pierre; Weaver, Marcia R

2016-08-04

Integrated Infectious Diseases Capacity Building Evaluation (IDCAP) teams designed and implemented two health worker in-service training approaches: 1) an off-site classroom-based integrated management of infectious diseases (IMID) course with distance learning aspects, and 2) on-site support (OSS), an educational outreach intervention. We tested the effects of OSS on workload and 12 facility performance indicators for emergency triage assessment and treatment, HIV testing, and malaria and pneumonia case management among outpatients by two subgroups: 1) mid-level practitioners (MLP) who attended IMID training (IMID-MLP) and 2) health workers who did not (No-IMID). Thirty-six health facilities participated in the IDCAP trial, with 18 randomly assigned to Arm A and 18 to Arm B. Two MLP in both arms received IMID. All providers at Arm A facilities received nine monthly OSS visits from April to December 2010 while Arm B did not. From November 2009 to December 2010, 777,667 outpatient visits occurred. We analyzed 669,580 (86.1 %) outpatient visits, where provider cadre was reported. Treatment was provided by 64 IMID-MLP and 1,515 No-IMID providers. The effect of OSS was measured by the difference in pre/post changes across arms after controlling for covariates (adjusted ratio of relative risks = a RRR). The effect of OSS on patients-per-provider-per-day (workload) among IMID-MLP (aRRR = 1.21; p = 0.48) and No-IMID (aRRR = 0.90; p = 0.44) was not statistically significant. Among IMID-MLP, OSS was effective for three indicators: malaria cases receiving an appropriate antimalarial (aRRR = 1.26, 99 % CI = 1.02-1.56), patients with negative malaria test result prescribed an antimalarial (aRRR = 0.49, 99 % CI = 0.26-0.92), and patients with acid-fast bacilli smear negative result receiving empiric treatment for acute respiratory infection (aRRR = 2.04, 99 % CI = 1.06-3.94). Among No-IMID, OSS was effective for two indicators: emergency and priority patients admitted, detained or referred (aRRR = 2.12, 99 % CI = 1.05-4.28) and emergency patients receiving at least one appropriate treatment (aRRR = 1.98, 99 % CI = 1.21-3.24). Effects of OSS on workload were not statistically significant. Significant OSS effects on facility performance across subgroups were heterogeneous. OSS supported MLP who diagnosed and treated patients to apply IMID knowledge. For other providers, OSS supported team work to manage emergency patients. This evidence on OSS effectiveness could inform interventions to improve health workers' capacity to deliver better quality infectious diseases care.

View of VAB from Mobile Launcher

NASA Image and Video Library

2017-03-13

A view of the north side of the Vehicle Assembly Building (VAB) from the top of the mobile launcher tower at NASA's Kennedy Space Center in Florida. Inside the VAB, 10 levels of platforms, 20 platform halves altogether, have been installed in High Bay 3. The platforms will surround NASA's Space Launch System (SLS) rocket and the Orion spacecraft and allow access during processing for missions, including the first uncrewed flight test of Orion atop the SLS rocket in 2018. Crawler-transporter 2 will carry the rocket and spacecraft atop the mobile launcher to Launch Pad 39B for Exploration Mission 1. The Ground Systems Development and Operations Program, with support from the center's Engineering Directorate, is overseeing upgrades and modifications to the VAB and the mobile launcher.

Expression of cathepsin S antisense transcripts by adenovirus in retinal pigment epithelial cells.

PubMed

Rakoczy, P E; Lai, M C; Baines, M G; Spilsbury, K; Constable, I J

1998-10-01

To show the production of sense or antisense transcripts by recombinant adenoviruses, to investigate whether the transcripts produced were suitable for downregulating the expression of the targeted gene, cathepsin S (CatS), and to examine the effect of antisense transcript production on the biologic function of retinal pigment epithelial (RPE) cells, including the regulation of endogenous aspartic protease expression. Ad.MLP.CatSAS, Ad.RSV.CatSAS, and Ad.MLP.CatSS recombinant viruses were produced by homologous recombination. The recombinant viruses were tested by restriction enzyme digestion to confirm the orientation of the inserts. The expression of antisense transcripts was tested by northern blot analysis. Western blot analysis was used to study the regulation of the endogenous CatS protein in ARPE19 cells. The biologic effect of CatS downregulation in ARPE19 cells was tested by proliferation and phagocytosis assays, de novo cathepsin D (CatD) synthesis, and measurement of aspartic protease activity. After characterization of the recombinant adenovirus constructs, the production of antisense and sense CatS transcripts was shown in ARPE19 cells. The transcripts appeared at approximately 1.9 kb 48 hours after transduction, and the expression of the antisense transcripts was similar in constructs carrying either the MLP or the RSV promoter. Western blot analysis showed that ARPE19 cells transduced with Ad.MLP.CatSAS and Ad.RSV.CatSAS had no detectable CatS. In contrast, there was a strong signal appearing at 24 kDa in ARPE19 cells transduced with Ad.MLP.CatSS. ARPE19 cells were transduced to a high level. The transduction of ARPE19 cells with the recombinant adenoviruses did not affect the morphologic appearance of the cells, their proliferation, or their phagocytosing ability. However, ARPE19 cells transduced by Ad.MLP.CatSAS recombinant adenovirus showed a significant downregulation of de novo CatD synthesis and a twofold decrease in aspartic protease activity. Recombinant adenoviruses were shown to be suitable for producing antisense CatS transcripts to modulate endogenous CatS expression in RPE cells. It is proposed that CatS may play an important role, directly or indirectly, in the lysosomal digestion of outer segments through the regulation of other lysosomal enzyme activity, such as the expression of CatD.

KSC-02pd0398

NASA Image and Video Library

2002-04-04

KENNEDY SPACE CENTER, FLA. -- At Launch Pad 39B, an inspection team gathers at the foot of Mobile Launcher Platform where Space Shuttle Atlantis sits. Earlier today a leak in a ground support liquid hydrogen vent line on the south side of the Mobile Launcher Platform caused a scrub of the launch of Atlantis on mission STS-110. An engineering team is assessing the situation to determine the best method to repair the hydrogen line. The turnaround plan includes time to perfor weld repairs and return the vehicle to a timeline to resume the countdown

KSC-02pd0396

NASA Image and Video Library

2002-04-04

KENNEDY SPACE CENTER, FLA. -- At Launch Pad 39B, workers on a crane inspect pipes on the Mobile Launcher Platform where Space Shuttle Atlantis sits. Earlier today a leak in a ground support liquid hydrogen vent line on the south side of the Mobile Launcher Platform caused a scrub of the launch of Atlantis on mission STS-110. An engineering team is assessing the situation to determine the best method to repair the hydrogen line. The turnaround plan includes time to perfor weld repairs and return the vehicle to a timeline to resume the countdown

NUCLEAR PORE ANCHOR, the Arabidopsis Homolog of Tpr/Mlp1/Mlp2/Megator, Is Involved in mRNA Export and SUMO Homeostasis and Affects Diverse Aspects of Plant Development[W

PubMed Central

Xu, Xianfeng Morgan; Rose, Annkatrin; Muthuswamy, Sivaramakrishnan; Jeong, Sun Yong; Venkatakrishnan, Sowmya; Zhao, Qiao; Meier, Iris

2007-01-01

Vertebrate Tpr and its yeast homologs Mlp1/Mlp2, long coiled-coil proteins of nuclear pore inner basket filaments, are involved in mRNA export, telomere organization, spindle pole assembly, and unspliced RNA retention. We identified Arabidopsis thaliana NUCLEAR PORE ANCHOR (NUA) encoding a 237-kD protein with similarity to Tpr. NUA is located at the inner surface of the nuclear envelope in interphase and in the vicinity of the spindle in prometaphase. Four T-DNA insertion lines were characterized, which comprise an allelic series of increasing severity for several correlating phenotypes, such as early flowering under short days and long days, increased abundance of SUMO conjugates, altered expression of several flowering regulators, and nuclear accumulation of poly(A)+ RNA. nua mutants phenocopy mutants of EARLY IN SHORT DAYS4 (ESD4), an Arabidopsis SUMO protease concentrated at the nuclear periphery. nua esd4 double mutants resemble nua and esd4 single mutants, suggesting that the two proteins act in the same pathway or complex, supported by yeast two-hybrid interaction. Our data indicate that NUA is a component of nuclear pore-associated steps of sumoylation and mRNA export in plants and that defects in these processes affect the signaling events of flowering time regulation and additional developmental processes. PMID:17513499

Molecular evolution of miraculin-like proteins in soybean Kunitz super-family.

PubMed

Selvakumar, Purushotham; Gahloth, Deepankar; Tomar, Prabhat Pratap Singh; Sharma, Nidhi; Sharma, Ashwani Kumar

2011-12-01

Miraculin-like proteins (MLPs) belong to soybean Kunitz super-family and have been characterized from many plant families like Rutaceae, Solanaceae, Rubiaceae, etc. Many of them possess trypsin inhibitory activity and are involved in plant defense. MLPs exhibit significant sequence identity (~30-95%) to native miraculin protein, also belonging to Kunitz super-family compared with a typical Kunitz family member (~30%). The sequence and structure-function comparison of MLPs with that of a classical Kunitz inhibitor have demonstrated that MLPs have evolved to form a distinct group within Kunitz super-family. Sequence analysis of new genes along with available MLP sequences in the literature revealed three major groups for these proteins. A significant feature of Rutaceae MLP type 2 sequences is the presence of phosphorylation motif. Subtle changes are seen in putative reactive loop residues among different MLPs suggesting altered specificities to specific proteases. In phylogenetic analysis, Rutaceae MLP type 1 and type 2 proteins clustered together on separate branches, whereas native miraculin along with other MLPs formed distinct clusters. Site-specific positive Darwinian selection was observed at many sites in both the groups of Rutaceae MLP sequences with most of the residues undergoing positive selection located in loop regions. The results demonstrate the sequence and thereby the structure-function divergence of MLPs as a distinct group within soybean Kunitz super-family due to biotic and abiotic stresses of local environment.

Hormonal regulation of platypus Beta-lactoglobulin and monotreme lactation protein genes.

PubMed

Enjapoori, Ashwantha Kumar; Lefèvre, Christophe M; Nicholas, Kevin R; Sharp, Julie A

2017-02-01

Endocrine regulation of milk protein gene expression in marsupials and eutherians is well studied. However, the evolution of this complex regulation that began with monotremes is unknown. Monotremes represent the oldest lineage of extant mammals and the endocrine regulation of lactation in these mammals has not been investigated. Here we characterised the proximal promoter and hormonal regulation of two platypus milk protein genes, Beta-lactoglobulin (BLG), a whey protein and monotreme lactation protein (MLP), a monotreme specific milk protein, using in vitro reporter assays and a bovine mammary epithelial cell line (BME-UV1). Insulin and dexamethasone alone provided partial induction of MLP, while the combination of insulin, dexamethasone and prolactin was required for maximal induction. Partial induction of BLG was achieved by insulin, dexamethasone and prolactin alone, with maximal induction using all three hormones. Platypus MLP and BLG core promoter regions comprised transcription factor binding sites (e.g. STAT5, NF-1 and C/EBPα) that were conserved in marsupial and eutherian lineages that regulate caseins and whey protein gene expression. Our analysis suggests that insulin, dexamethasone and/or prolactin alone can regulate the platypus MLP and BLG gene expression, unlike those of therian lineage. The induction of platypus milk protein genes by lactogenic hormones suggests they originated before the divergence of marsupial and eutherians. Copyright © 2015 Elsevier Inc. All rights reserved.

Method for Producing Launch/Landing Pads and Structures Project

NASA Technical Reports Server (NTRS)

Mueller, Robert P. (Compiler)

2015-01-01

Current plans for deep space exploration include building landing-launch pads capable of withstanding the rocket blast of much larger spacecraft that that of the Apollo days. The proposed concept will develop lightweight launch and landing pad materials from in-situ materials, utilizing regolith to produce controllable porous cast metallic foam brickstiles shapes. These shapes can be utilized to lay a landing launch platform, as a construction material or as more complex parts of mechanical assemblies.

KSC-99pc0142

NASA Image and Video Library

1999-01-28

The KSC-developed X-33 weight simulator (top), known as the "iron bird," is lifted to a vertical position at the X-33 launch site as part of launch equipment testing on Edwards Air Force Base, CA. The simulator matches the 75,000-pound weight and 63-foot height of the X-33 vehicle that will be using the launch equipment. KSC's Vehicle Positioning System (VPS) placed the simulator on the rotating launch platform prior to the rotation. The new VPS will dramatically reduce the amount of manual labor required to position a reusable launch vehicle for liftoff

KSC-99pc0145

NASA Image and Video Library

1999-01-28

The KSC-developed X-33 weight simulator (top, right), known as the "iron bird," is lifted to a vertical position at the X-33 launch site as part of launch equipment testing on Edwards Air Force Base, CA. The simulator matches the 75,000-pound weight and 63-foot height of the X-33 vehicle that will be using the launch equipment. KSC's Vehicle Positioning System (VPS) placed the simulator on the rotating launch platform prior to the rotation. The new VPS will dramatically reduce the amount of manual labor required to position a reusable launch vehicle for liftoff

KSC-99pc0144

NASA Image and Video Library

1999-01-28

The KSC-developed X-33 weight simulator (left), known as the "iron bird," is fully raised to a vertical position at the X-33 launch site as part of launch equipment testing on Edwards Air Force Base, CA. The simulator matches the 75,000-pound weight and 63-foot height of the X-33 vehicle that will be using the launch equipment. KSC's Vehicle Positioning System (VPS) placed the simulator on the rotating launch platform prior to the rotation. The new VPS will dramatically reduce the amount of manual labor required to position a reusable launch vehicle for liftoff

GENERAL VIEW OF VEHICLE ACCESS PLATFORM CNORTH, HB3, FACING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM C-NORTH, HB-3, FACING NORTHEAST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM ENORTH, HB3, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM E-NORTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM ENORTH, HB3, FACING NORTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM E-NORTH, HB-3, FACING NORTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM DNORTH, HB3, FACING NORTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM D-NORTH, HB-3, FACING NORTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF NORTH VEHICLE ACCESS PLATFORMS, HB3, FACING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF NORTH VEHICLE ACCESS PLATFORMS, HB-3, FACING NORTHEAST TOWARDS CEILING - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM BNORTH, HB3, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM B-NORTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM DNORTH, HB3, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM D-NORTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF NORTH VEHICLE ACCESS PLATFORMS, HB3, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF NORTH VEHICLE ACCESS PLATFORMS, HB-3, FACING NORTH TOWARDS FLOOR - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM BNORTH, HB3, FACING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM B-NORTH, HB-3, FACING NORTHEAST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM CNORTH, HB3, FACING NORTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM C-NORTH, HB-3, FACING NORTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

KSC-08pd3270

NASA Image and Video Library

2008-10-20

CAPE CANAVERAL, Fla. - Despite the incline, space shuttle Atlantis remains on a level plane as it rolls off Launch Pad 39A at NASA's Kennedy Space Center in Florida. First motion was at 6:48 a.m. EDT. The crawler-transporter underneath the mobile launcher platform maintains the level plane through a leveling system designed to keep the top of the space shuttle vehicle vertical. This system also provides the leveling operations required to negotiate the 5-percent ramp leading to the launch pads. Atlantis is rolling back to the Vehicle Assembly Building to await launch on its STS-125 mission to repair NASA's Hubble Space Telescope. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. The space shuttle is mounted on a Mobile Launcher Platform and will be delivered to the Vehicle Assembly Building atop a crawler transporter. traveling slower than 1 mph during the 3.4-mile journey. The rollback is expected to take approximately six hours. Photo credit: NASA/Kim Shiflett

[Rapid Identification of Epicarpium Citri Grandis via Infrared Spectroscopy and Fluorescence Spectrum Imaging Technology Combined with Neural Network].

PubMed

Pan, Sha-sha; Huang, Fu-rong; Xiao, Chi; Xian, Rui-yi; Ma, Zhi-guo

2015-10-01

To explore rapid reliable methods for detection of Epicarpium citri grandis (ECG), the experiment using Fourier Transform Attenuated Total Reflection Infrared Spectroscopy (FTIR/ATR) and Fluorescence Spectrum Imaging Technology combined with Multilayer Perceptron (MLP) Neural Network pattern recognition, for the identification of ECG, and the two methods are compared. Infrared spectra and fluorescence spectral images of 118 samples, 81 ECG and 37 other kinds of ECG, are collected. According to the differences in tspectrum, the spectra data in the 550-1 800 cm(-1) wavenumber range and 400-720 nm wavelength are regarded as the study objects of discriminant analysis. Then principal component analysis (PCA) is applied to reduce the dimension of spectroscopic data of ECG and MLP Neural Network is used in combination to classify them. During the experiment were compared the effects of different methods of data preprocessing on the model: multiplicative scatter correction (MSC), standard normal variable correction (SNV), first-order derivative(FD), second-order derivative(SD) and Savitzky-Golay (SG). The results showed that: after the infrared spectra data via the Savitzky-Golay (SG) pretreatment through the MLP Neural Network with the hidden layer function as sigmoid, we can get the best discrimination of ECG, the correct percent of training set and testing set are both 100%. Using fluorescence spectral imaging technology, corrected by the multiple scattering (MSC) results in the pretreatment is the most ideal. After data preprocessing, the three layers of the MLP Neural Network of the hidden layer function as sigmoid function can get 100% correct percent of training set and 96.7% correct percent of testing set. It was shown that the FTIR/ATR and fluorescent spectral imaging technology combined with MLP Neural Network can be used for the identification study of ECG and has the advantages of rapid, reliable effect.

Comparison of two different artificial neural networks for prostate biopsy indication in two different patient populations.

PubMed

Stephan, Carsten; Xu, Chuanliang; Finne, Patrik; Cammann, Henning; Meyer, Hellmuth-Alexander; Lein, Michael; Jung, Klaus; Stenman, Ulf-Hakan

2007-09-01

Different artificial neural networks (ANNs) using total prostate-specific antigen (PSA) and percentage of free PSA (%fPSA) have been introduced to enhance the specificity of prostate cancer detection. The applicability of independently trained ANN and logistic regression (LR) models to different populations regarding the composition (screening versus referred) and different PSA assays has not yet been tested. Two ANN and LR models using PSA (range 4 to 10 ng/mL), %fPSA, prostate volume, digital rectal examination findings, and patient age were tested. A multilayer perceptron network (MLP) was trained on 656 screening participants (Prostatus PSA assay) and another ANN (Immulite-based ANN [iANN]) was constructed on 606 multicentric urologically referred men. These and other assay-adapted ANN models, including one new iANN-based ANN, were used. The areas under the curve for the iANN (0.736) and MLP (0.745) were equal but showed no differences to %fPSA (0.725) in the Finnish group. Only the new iANN-based ANN reached a significant larger area under the curve (0.77). At 95% sensitivity, the specificities of MLP (33%) and the new iANN-based ANN (34%) were significantly better than the iANN (23%) and %fPSA (19%). Reverse methodology using the MLP model on the referred patients revealed, in contrast, a significant improvement in the areas under the curve for iANN and MLP (each 0.83) compared with %fPSA (0.70). At 90% and 95% sensitivity, the specificities of all LR and ANN models were significantly greater than those for %fPSA. The ANNs based on different PSA assays and populations were mostly comparable, but the clearly different patient composition also allowed with assay adaptation no unbiased ANN application to the other cohort. Thus, the use of ANNs in other populations than originally built is possible, but has limitations.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Atlantis roars into the clear blue sky from the billows of smoke below after launch on mission STS-112, the 15th assembly flight to the International Space Station. Liftoff from Launch Pad 39B occurred at 3:46 p.m. EDT. Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station.

KSC-98pc1179

NASA Image and Video Library

1998-09-28

KENNEDY SPACE CENTER, FLA. -- At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar-observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4-foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad

KSC-04PD-2561

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a Vehicle Assembly Building (VAB) high bay, workers monitor the movement of a Solid Rocket Booster (SRB) aft center segment as it is lowered toward an aft segment already secured to a Mobile Launch Platform. These segments are part of the right SRB for the Space Shuttle Return to Flight mission, STS-114. Two SRBs are stacked on a Mobile Launch Platform for each Shuttle flight and later joined by an External Tank. The twin 149-foot tall, 12-foot diameter SRBs provide the main propulsion system during launch. They operate in parallel with the Space Shuttle main engines for the first two minutes of flight and jettison away from the orbiter with help from the Booster Separation Motors, about 26.3 nautical miles above the Earths surface.

KSC-04PD-2562

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a Vehicle Assembly Building (VAB) high bay, workers check the alignment of a Solid Rocket Booster (SRB) aft center segment as it is lowered toward an aft segment already secured to a Mobile Launch Platform. These segments are part of the right SRB for the Space Shuttle Return to Flight mission, STS-114. Two SRBs are stacked on a Mobile Launch Platform for each Shuttle flight and later joined by an External Tank. The twin 149-foot tall, 12-foot diameter SRBs provide the main propulsion system during launch. They operate in parallel with the Space Shuttle main engines for the first two minutes of flight and jettison away from the orbiter with help from the Booster Separation Motors, about 26.3 nautical miles above the Earths surface.

KSC-04PD-2565

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a Vehicle Assembly Building (VAB) high bay, workers check the alignment of a Solid Rocket Booster (SRB) aft center segment which has been lowered onto an aft segment already secured to a Mobile Launch Platform. These segments are part of the right SRB for the Space Shuttle Return to Flight mission, STS-114. Two SRBs are stacked on a Mobile Launch Platform for each Shuttle flight and later joined by an External Tank. The twin 149-foot tall, 12-foot diameter SRBs provide the main propulsion system during launch. They operate in parallel with the Space Shuttle main engines for the first two minutes of flight and jettison away from the orbiter with help from the Booster Separation Motors, about 26.3 nautical miles above the Earths surface.

GENERAL VIEW OF THE MAIN FLOOR LEVEL, PLATFORM DSOUTH, HB3, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF THE MAIN FLOOR LEVEL, PLATFORM D-SOUTH, HB-3, FACING NORTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

DETAIL VIEW OF VIDEO CAMERA, MAIN FLOOR LEVEL, PLATFORM ESOUTH, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF VIDEO CAMERA, MAIN FLOOR LEVEL, PLATFORM E-SOUTH, HB-3, FACING SOUTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

The ExoMars Rover Science Archive: Status and Plans

NASA Astrophysics Data System (ADS)

Heather, D.; Lim, T.; Metcalfe, L.

2017-09-01

The ExoMars program is a co-operation between ESA and Roscosmos comprising two missions: the first, launched on 14 March 2016, included the Trace Gas Orbiter and Schiaparelli lander; the second, due for launch in 2020, will be a Rover and Surface Platform (RSP). The ExoMars Rover and Surface Platform deliveries will be among the first data in the PSA to be formatted according to the new PDS4 Standards, and will be the first rover data to be hosted within the archive at all. The archiving and management of the science data to be returned from ExoMars will require a significant development effort for the new Planetary Science Archive (PSA). This presentation will outline the current plans for archiving of the ExoMars Rover and Surface Platform science data.

24. AIRCONDITIONING DUCT, WINCH CONTROL BOX, AND SPEAKER AT STATION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. AIR-CONDITIONING DUCT, WINCH CONTROL BOX, AND SPEAKER AT STATION 85.5 OF MST. FOLDED-UP PLATFORM ON RIGHT OF PHOTO. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

DNA-launched live-attenuated vaccines for biodefense applications

PubMed Central

Pushko, Peter; Lukashevich, Igor S.; Weaver, Scott C.; Tretyakova, Irina

2016-01-01

Summary A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant plasmid that encodes the full-length genomic RNA of live-attenuated virus downstream from a eukaryotic promoter. When administered in vivo, the genomic RNA of live-attenuated virus is transcribed. The RNA initiates limited replication of a genetically defined, live-attenuated vaccine virus in the tissues of the vaccine recipient, thereby inducing a protective immune response. This platform combines the strengths of reverse genetics, DNA immunization and the advantages of live-attenuated vaccines, resulting in a reduced chance of genetic reversions, increased safety, and improved immunization. With this vaccine technology, the field of DNA vaccines is expanded from those that express subunit antigens to include a novel type of DNA vaccines that launch live-attenuated viruses. PMID:27055100

KSC-98pc1044

NASA Image and Video Library

1998-08-06

In this aerial view the Crawler Transporter Maintenance Building (center) sits between two crawler transporters. The KSC crawlers are the largest tracked vehicles known. Once used to move assembled Apollo/Saturn from the VAB to the launch pad, they are now used for transporting Shuttle vehicles. They move the Mobile Launcher Platform into the Vehicle Assembly Building and then to the Launch Pad with an assembled space vehicle. Maximum speed is 1.6 km (one mile) per hour loaded, about 3.2 km (2 miles) per hour unloaded. Launch Pad to VAB trip time with the Mobile Launch Platform is about 5 hours. The crawler burns 568 liters (150 gallons) of diesel oil per mile. KSC's two crawlers have accumulated 1,243 miles since 1977. Including the Apollo years, the transporters have racked up 2,526 miles, about the same distance as a one-way trip from KSC to Los Angeles by interstate highway or a round trip between KSC and New York City

Aerial view of the KSC crawler transporters

NASA Technical Reports Server (NTRS)

1998-01-01

In this aerial view the Crawler Transporter Maintenance Building (center) sits between two crawler transporters. The KSC crawlers are the largest tracked vehicles known. Once used to move assembled Apollo/Saturn from the VAB to the launch pad, they are now used for transporting Shuttle vehicles. They move the Mobile Launcher Platform into the Vehicle Assembly Building and then to the Launch Pad with an assembled space vehicle. Maximum speed is 1.6 km (one mile) per hour loaded, about 3.2 km (2 miles) per hour unloaded. Launch Pad to VAB trip time with the Mobile Launch Platform is about 5 hours. The crawler burns 568 liters (150 gallons) of diesel oil per mile. KSC's two crawlers have accumulated 1,243 miles since 1977. Including the Apollo years, the transporters have racked up 2,526 miles, about the same distance as a one-way trip from KSC to Los Angeles by interstate highway or a round trip between KSC and New York City.

Development of an in Silico Model of DPPH• Free Radical Scavenging Capacity: Prediction of Antioxidant Activity of Coumarin Type Compounds.

PubMed

Goya Jorge, Elizabeth; Rayar, Anita Maria; Barigye, Stephen J; Jorge Rodríguez, María Elisa; Sylla-Iyarreta Veitía, Maité

2016-06-07

A quantitative structure-activity relationship (QSAR) study of the 2,2-diphenyl-l-picrylhydrazyl (DPPH•) radical scavenging ability of 1373 chemical compounds, using DRAGON molecular descriptors (MD) and the neural network technique, a technique based on the multilayer multilayer perceptron (MLP), was developed. The built model demonstrated a satisfactory performance for the training ( R 2 = 0.713 ) and test set ( Q ext 2 = 0.654 ) , respectively. To gain greater insight on the relevance of the MD contained in the MLP model, sensitivity and principal component analyses were performed. Moreover, structural and mechanistic interpretation was carried out to comprehend the relationship of the variables in the model with the modeled property. The constructed MLP model was employed to predict the radical scavenging ability for a group of coumarin-type compounds. Finally, in order to validate the model's predictions, an in vitro assay for one of the compounds (4-hydroxycoumarin) was performed, showing a satisfactory proximity between the experimental and predicted pIC50 values.

Destabilising automobility? The emergent mobilities of generation Y.

PubMed

Hopkins, Debbie

2017-04-01

This paper uses empirical material gathered with young adults in New Zealand to examine a potential sustainability transition-in-practice. It draws from two frameworks; the actor-centred Energy Cultures Framework to explore mobility behaviours, and the multi-level perspective (MLP) to situate behaviour change within the socio-technical transitions literature. The MLP has traditionally been used to analyse historical transitions (e.g. from the horse and cart to the motor vehicle), but in this paper, it is used to explore an on-going change trend; the emergent mobilities of young adults who appear to be aspiring for different types of mobility. A series of mobility trends are described, which emerged from a programme of qualitative interviews (n = 51). The material culture, norms and practices that constitute these trends are articulated. These are then considered through the lens of the MLP. The evidence points to emergent trends of multimodality that, if leveraged upon and supported, could contribute to a systemic sustainability transition.

Doctors and lawyers collaborating to HeLP children--outcomes from a successful partnership between professions.

PubMed

Klein, Melissa D; Beck, Andrew F; Henize, Adrienne W; Parrish, Donita S; Fink, Elaine E; Kahn, Robert S

2013-08-01

Clear associations exist between socioeconomic risks and health, and these risks are often amenable to legal interventions. This is a case study of an implementation of a medical-legal partnership (MLP) in three pediatric primary care centers that serve a predominantly high-risk population. Referral circumstances and outcomes over the first three years are described. During the three-year study period, 1,808 MLP referrals were made for 1,614 patients by all levels of provider. Those referred were more likely to have asthma (p<.0001) and developmental delay/behavioral disorder (p<.0001) than the general clinic population. Housing (37%) and income/health benefit (33%) problems were the most common reasons for referral. Referrals led to 1,742 (89%) positive legal outcomes affecting nearly 6,000 cohabitating children and adults and translating into nearly $200,000 in recovered back benefits. Successful MLP implementation enabled pediatric providers to address social determinants of health potentially improving health and reducing disparities.

STS-29 Discovery, Orbiter Vehicle (OV) 103, roll out to KSC LC Pad 39B

NASA Technical Reports Server (NTRS)

1989-01-01

In the early morning hours, STS-29 Discovery, Orbiter Vehicle (OV) 103, mated to the external tank (ET) and solid rocket boosters (SRBs) is rolled out to Kennedy Space Center (KSC) Launch Complex (LC) Pad 39B atop the mobile launcher platform. Trees, shrubs, and a light mist surround the mobile launcher platform as it makes its way to LC Pad 39B. OV-103 will fly on Mission STS-29 scheduled for launch in mid-March. View provided by KSC with alternate KSC number KSC-89PC-50.

SO-QT: Collaborative Tool to Project the Future Space Object Population

NASA Technical Reports Server (NTRS)

Stupl, Jan

2017-01-01

Earth orbit gets increasingly congested, a challenge to space operators, both in governments and industry. We present a web tool that provides: 1) data on todays and the historic space object environments, by aggregating object-specific tracking data; and 2) future trends through a collaboration platform to collect information on planed launches. The collaborative platform enables experts to pool and compare their data in order to generate future launch scenarios. The tool is intended to support decision makers and mission designers while they investigate future missions and scholars as they develop strategies for space traffic management.

Rocket Launch Trajectory Simulations Mechanism

NASA Technical Reports Server (NTRS)

Margasahayam, Ravi; Caimi, Raoul E.; Hauss, Sharon; Voska, N. (Technical Monitor)

2002-01-01

The design and development of a Trajectory Simulation Mechanism (TSM) for the Launch Systems Testbed (LST) is outlined. In addition to being one-of-a-kind facility in the world, TSM serves as a platform to study the interaction of rocket launch-induced environments and subsequent dynamic effects on the equipment and structures in the close vicinity of the launch pad. For the first time, researchers and academicians alike will be able to perform tests in a laboratory environment and assess the impact of vibroacoustic behavior of structures in a moving rocket scenario on ground equipment, launch vehicle, and its valuable payload or spacecraft.

ARC-1980-AC80-0107-19

NASA Image and Video Library

1980-02-06

Space Shuttle Orbiter Enterprise mated to an external fuel tank and two solid rocket boosters on top of a Mobil Launcher Platform, undergoes fit and function checks at the launch site for the first Space Shuttle at Launch Complex 39's Pad A. The dummy Space Shuttle was assembled in the Vehicle Assembly Building and rolled out to the launch site on May 1 as part of an exercise to make certain shuttle elements are compatible with the Spaceport's assembly and launch facilities and ground support equipment, and help clear the way for the launch of the Space Shuttle Orbiter Columbia.

ARC-1980-AC80-0107-14

NASA Image and Video Library

1980-02-06

SPACE SHUTTLE ORBITER ENTERPRISE MATED TO AN EXTERNAL FUEL TANK AND TWO SOLID ROCKET BOOSTERS ON TOP OF A MOBIL LAUNCHER PLATFORM, UNDERGOES FIT AND FUNCTION CHECKS AT THE LAUNCH SITE FOR THE FIRST SPACE SHUTTLE AT LAUNCH COMPLEX 39'S PAD A. THE DUMMY SPACE SHUTTLE WAS ASSEMBLED IN THE VEHICLE ASSEMBLY BUILDING AND ROLLED OUT TO THE LAUNCH SITE ON MAY 1 AS PART OF AN EXERCISE TO MAKE CERTAIN SHUTTLE ELEMENTS ARE COMPATIBLE WITH THE SPACEPORT'S ASSEMBLY AND LAUNCH FACILITIES AND GROUND SUPPORT EQUIPMENT, AND HELP CLEAR THE WAY FOR THE LAUNCH OF THE SPACE SHUTTLE ORBITER COLUMBIA.

ARC-1980-AC80-0107-17

NASA Image and Video Library

1980-02-06

SPACE SHUTTLE ORBITER ENTERPRISE MATED TO AN EXTERNAL FUEL TANK AND TWO SOLID ROCKET BOOSTERS ON TOP OF A MOBIL LAUNCHER PLATFORM, UNDERGOES FIT AND FUNCTION CHECKS AT THE LAUNCH SITE FOR THE FIRST SPACE SHUTTLE AT LAUNCH COMPLEX 39'S PAD A. THE DUMMY SPACE SHUTTLE WAS ASSEMBLED IN THE VEHICLE ASSEMBLY BUILDING AND ROLLED OUT TO THE LAUNCH SITE ON MAY 1 AS PART OF AN EXERCISE TO MAKE CERTAIN SHUTTLE ELEMENTS ARE COMPATIBLE WITH THE SPACEPORT'S ASSEMBLY AND LAUNCH FACILITIES AND GROUND SUPPORT EQUIPMENT, AND HELP CLEAR THE WAY FOR THE LAUNCH OF THE SPACE SHUTTLE ORBITER COLUMBIA.

KSC-99pc0143

NASA Image and Video Library

1999-01-28

As part of X-33 launch equipment testing at Edwards Air Force Base, CA, the KSC-developed X-33 weight simulator (top), known as the "iron bird," is lifted to a vertical position at the X-33 launch site. The simulator matches the 75,000-pound weight and 63-foot height of the X-33 vehicle that will be using the launch equipment. KSC's Vehicle Positioning System (VPS) placed the simulator on the rotating launch platform prior to the rotation. The new VPS will dramatically reduce the amount of manual labor required to position a reusable launch vehicle for liftoff

Air Launch: Examining Performance Potential of Various Configurations and Growth Options

NASA Technical Reports Server (NTRS)

Waters, Eric D.; Creech, Dennis M.; Philips, Alan D.

2013-01-01

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a high-level analysis of various air launch vehicle configurations, objectively determining maximum launch vehicle payload while considering carrier aircraft capabilities and given dimensional constraints. With the renewed interest in aerial launch of low-earth orbit payloads, referenced by programs such as Stratolaunch and Spaceship2, there exists a need to qualify the boundaries of the trade space, identify performance envelopes, and understand advantages and limiting factors of designing for maximum payload capability. Using the NASA/DARPA Horizontal Launch Study (HLS) Point Design 2 (PD-2) as a pointof- departure configuration, two independent design actions were undertaken. Both designs utilized a Boeing 747-400F as the carrier aircraft, LOX/RP-1 first stage and LOX/LH2 second stage. Each design was sized to meet dimensional and mass constraints while optimizing propellant loads and stage delta V splits. All concepts, when fully loaded, exceeded the allowable Gross Takeoff Weight (GTOW) of the aircraft platform. This excess mass was evaluated as propellant/fuel offload available for a potential in-flight propellant loading scenario. Results indicate many advantages such as payload delivery of approximately 47,000 lbm and significant mission flexibility including variable launch site inclination and launch window. However, in-flight cryogenic fluid transfer and carrier aircraft platform integration are substantial technical hurdles to the realization of such a system configuration.

[Association between neontal morbidity, gestational age and developmental delays in moderate to late preterm children].

PubMed

Schonhaut, Luisa; Pérez, Marcela; Muñoz, Sergio

2015-01-01

There is evidence that children born moderate-to-late preterm (MLP) have a higher risk of hospitalisation, neonatal morbidity, and developmental delay (DD). To determine the association between DD, gestational age, and neonatal morbidity in MLP children. A case control study design nested in a cohort of MLP children born between 2006 and 2009 at a private hospital located in the Metropolitan area of Santiago. The children were assessed with the Bayley-III Scales of Infant Development at 8 or 18 months corrected age, or at 30 months of chronological age. Neonatal records were retrospectively reviewed. A multivariate analysis was performed to determine the effect of neonatal morbidity on development. A total of 130 MLP children, 25 cases and 105 controls, were studied. Most of them (83.8%) were hospitalised during the neonatal period. Significant differences between cases and controls regarding maternal age and symptomatic hypoglycaemia were observed (crude OR 3.5, adjusted OR 8.18). It was concluded that the variables that negatively affect the rate of development are male gender, being a twin, and gestational age. Symptomatic hypoglycaemia is the main risk factor for DD, while being a twin, male gender, and gestational age influenced the total development rate obtained. It is essential to develop strategies for prevention, screening, and early management of this metabolic disorder to prevent future DD. Copyright © 2015 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

73. LIQUID NITROGEN PUMPING STATION ON WEST SIDE OF MST; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

73. LIQUID NITROGEN PUMPING STATION ON WEST SIDE OF MST; NITROGEN EXCHANGERS ON RIGHT. SOUTHWEST CORNER OF MST VISIBLE; ENVIRONMENTAL CURTAIN SWING AND PLATFORM EXTENDED. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

KSC-02pd1890

NASA Image and Video Library

2002-12-09

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia, atop the Mobile Launcher Platform, approaches the top of Launch Pad 39A where it will undergo preparations for launch. The STS-107 research mission comprises experiments ranging from material sciences to life sciences, plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.

KSC-07pd1200

NASA Image and Video Library

2007-05-15

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Atlantis, mounted on a mobile launch platform, finally rests on the hard stand of Launch Pad 39A after an early morning rollout. This is the second rollout for the shuttle. Seen on either side of the main engine exhaust hole on the launcher platform are the tail service masts. Their function is to provide umbilical connections for liquid oxygen and liquid hydrogen lines to fuel the external tank from storage tanks adjacent to the launch pad. Other umbilical lines carry helium and nitrogen, as well as ground electrical power and connections for vehicle data and communications. First motion out of the Vehicle Assembly Building was at 5:02 a.m. EDT. In late February, while Atlantis was on the launch pad, Atlantis' external tank received hail damage during a severe thunderstorm that passed through the Kennedy Space Center Launch Complex 39 area. The hail caused visible divots in the giant tank's foam insulation, as well as minor surface damage to about 26 heat shield tiles on the shuttle's left wing. The shuttle was returned to the VAB for repairs. The launch of Space Shuttle Atlantis on mission STS-117 is now targeted for June 8. A flight readiness review will be held on May 30 and 31. Photo credit: NASA/Troy Cryder

Payload canister for Discovery is lifted in place for transfer

NASA Technical Reports Server (NTRS)

1998-01-01

At left, the payload canister for Space Shuttle Discovery is lifted from its canister movement vehicle to the top of the Rotating Service Structure on Launch Pad 39-B. Discovery (right), sitting atop the Mobile Launch Platform and next to the Fixed Service Structure (FSS), is scheduled for launch on Oct. 29, 1998, for the STS-95 mission. That mission includes the International Extreme Ultraviolet Hitchhiker (IEH-3), the Hubble Space Telescope Orbital Systems Test Platform, the Spartan solar- observing deployable spacecraft, and the SPACEHAB single module with experiments on space flight and the aging process. At the top of the FSS can be seen the 80-foot lightning mast . The 4- foot-high lightning rod on top helps prevent lightning current from passing directly through the Space Shuttle and the structures on the pad.

Platform options for the Space Station program

NASA Technical Reports Server (NTRS)

Mangano, M. J.; Rowley, R. W.

1986-01-01

Platforms for polar and 28.5 deg orbits were studied to determine the platform requirements and characteristics necessary to support the science objectives. Large platforms supporting the Earth-Observing System (EOS) were initially studied. Co-orbiting platforms were derived from these designs. Because cost estimates indicated that the large platform approach was likely to be too expensive, require several launches, and generally be excessively complex, studies of small platforms were undertaken. Results of these studies show the small platform approach to be technically feasible at lower overall cost. All designs maximized hardware inheritance from the Space Station program to reduce costs. Science objectives as defined at the time of these studies are largely achievable.

Design and Performance of a Spectrometer for Deployment on MISSE 7

NASA Technical Reports Server (NTRS)

Pippin, Gary; Beymer, Jim; Robb, Andrew; Longino, James; Perry, George; Stewart, Alan; Finkenor, Miria

2009-01-01

A spectrometer for reflectance and transmission measurements of samples exposed to the space environment has been developed for deployment on the Materials on the International Space Station Experiment (MISSE) 7. The instrument incorporates a miniature commercial fiber optic coupled spectrometer with a computer control system for detector operation, sample motion and illumination. A set of three spectrometers were recently integrated on the MISSE7 platform with launch and deployment on the International Space Station scheduled for summer of this year. The instrument is one of many active experiments on the platform. The performance of the instrument prior to launch will be discussed. Data from samples measured in the laboratory will be compared to those from the instrument prior to launch. These comparisons will illustrate the capabilities of the current design. The space environment challenges many materials. When in operation on the MISSE 7 platform, the new spectrometer will provide real time data on the how the space environment affects the optical properties of thermal control paints and optical coatings. Data obtained from comparison of pre and post flight measurements on hundreds of samples exposed on previous MISSE platforms have been reported at these meetings. With the new spectrometer and the ability to correlate measured changes with time on orbit and the occurrence of both natural events and human activities, a better understanding of the processes responsible for degradation of materials in space will be possible.

KSC-2009-2539

NASA Image and Video Library

2009-04-06

CAPE CANAVERAL, Fla. – Water cascades over the side of the mobile launcher platform on Launch Pad 39B at NASA's Kennedy Space Center in Florida. The sound suppression system is being tested on the platform. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X flight test that is targeted for summer 2009. The mobile launcher platform was handed over to the Constellation Program and modified for the Ares I-X flight test. It is being tested before being moved to the Vehicle Assembly Building for assembly of the Ares I-X rocket. A sound suppression water system is in¬stalled on the pads to protect against damage by acoustical energy and rocket exhaust reflected from the flame trench and mobile launcher plat¬form during a launch. The sound suppression system includes an elevated 290-foot-high water tank with a capacity of 300,000 gallons. The water releases just prior to the ignition of the rocket and flows through 7-foot-diameter pipes for about 20 seconds. A torrent of water will flow onto the mobile launcher platform from six large quench nozzles, or “rainbirds,” mounted on its surface. The rainbirds are 12 feet high. The two in the center are 42 inches in diameter; the other four have a 30-inch diameter. Photo credit: NASA/Dimitri Gerondidakis

Launch Control Systems: Moving Towards a Scalable, Universal Platform for Future Space Endeavors

NASA Technical Reports Server (NTRS)

Sun, Jonathan

2011-01-01

The redirection of NASA away from the Constellation program calls for heavy reliance on commercial launch vehicles for the near future in order to reduce costs and shift focus to research and long term space exploration. To support them, NASA will renovate Kennedy Space Center's launch facilities and make them available for commercial use. However, NASA's current launch software is deeply connected with the now-retired Space Shuttle and is otherwise not massively compatible. Therefore, a new Launch Control System must be designed that is adaptable to a variety of different launch protocols and vehicles. This paper exposits some of the features and advantages of the new system both from the perspective of the software developers and the launch engineers.

Environmental statement for National Aeronautics and Space Administration, Office of Space Science, launch vehicle and propulsion programs

NASA Technical Reports Server (NTRS)

1972-01-01

NASA OSS Launch Vehicle and Propulsion Programs are responsible for the launch of approximately 20 automated science and applications spacecraft per year. These launches are for NASA programs and those of other U. S. government agencies, private organizations, such as the Comsat Corporation, foreign countries, and international organizations. Launches occur from Cape Kennedy, Florida; Vandenberg Air Force Base, California; Wallops Island, Virginia; and the San Marco Platform in the Indian Ocean off Kenya. Spacecraft launched by this program contribute in a variety of ways to the control of and betterment of the environment. Environmental effects caused by the launch vehicles are limited in extent, duration, and intensity and are considered insignificant.

Multivariate Analysis and Modeling of Sediment Pollution Using Neural Network Models and Geostatistics

NASA Astrophysics Data System (ADS)

Golay, Jean; Kanevski, Mikhaïl

2013-04-01

The present research deals with the exploration and modeling of a complex dataset of 200 measurement points of sediment pollution by heavy metals in Lake Geneva. The fundamental idea was to use multivariate Artificial Neural Networks (ANN) along with geostatistical models and tools in order to improve the accuracy and the interpretability of data modeling. The results obtained with ANN were compared to those of traditional geostatistical algorithms like ordinary (co)kriging and (co)kriging with an external drift. Exploratory data analysis highlighted a great variety of relationships (i.e. linear, non-linear, independence) between the 11 variables of the dataset (i.e. Cadmium, Mercury, Zinc, Copper, Titanium, Chromium, Vanadium and Nickel as well as the spatial coordinates of the measurement points and their depth). Then, exploratory spatial data analysis (i.e. anisotropic variography, local spatial correlations and moving window statistics) was carried out. It was shown that the different phenomena to be modeled were characterized by high spatial anisotropies, complex spatial correlation structures and heteroscedasticity. A feature selection procedure based on General Regression Neural Networks (GRNN) was also applied to create subsets of variables enabling to improve the predictions during the modeling phase. The basic modeling was conducted using a Multilayer Perceptron (MLP) which is a workhorse of ANN. MLP models are robust and highly flexible tools which can incorporate in a nonlinear manner different kind of high-dimensional information. In the present research, the input layer was made of either two (spatial coordinates) or three neurons (when depth as auxiliary information could possibly capture an underlying trend) and the output layer was composed of one (univariate MLP) to eight neurons corresponding to the heavy metals of the dataset (multivariate MLP). MLP models with three input neurons can be referred to as Artificial Neural Networks with EXternal drift (ANNEX). Moreover, the exact number of output neurons and the selection of the corresponding variables were based on the subsets created during the exploratory phase. Concerning hidden layers, no restriction were made and multiple architectures were tested. For each MLP model, the quality of the modeling procedure was assessed by variograms: if the variogram of the residuals demonstrates pure nugget effect and if the level of the nugget exactly corresponds to the nugget value of the theoretical variogram of the corresponding variable, all the structured information has been correctly extracted without overfitting. Finally, it is worth mentioning that simple MLP models are not always able to remove all the spatial correlation structure from the data. In that case, Neural Network Residual Kriging (NNRK) can be carried out and risk assessment can be conducted with Neural Network Residual Simulations (NNRS). Finally, the results of the ANNEX models were compared to those of ordinary (co)kriging and (co)kriging with an external drift. It was shown that the ANNEX models performed better than traditional geostatistical algorithms when the relationship between the variable of interest and the auxiliary predictor was not linear. References Kanevski, M. and Maignan, M. (2004). Analysis and Modelling of Spatial Environmental Data. Lausanne: EPFL Press.

KSC01KODI035

NASA Image and Video Library

2001-05-29

KODIAK ISLAND, Alaska -- A special platform connects the barge with a ramp to allow Castor 120, the first stage of the Athena 1 launch vehicle, to safely move onto the dock at Kodiak Island, Alaska, as preparations to launch Kodiak Star proceed. The first orbital launch to take place from Alaska's Kodiak Launch Complex, Kodiak Star is scheduled to lift off on a Lockheed Martin Athena I launch vehicle on Sept. 17 during a two-hour window that extends from 5:00 to 7:00 p.m. ADT. The payloads aboard include the Starshine 3, sponsored by NASA, and the PICOSat, PCSat and Sapphire, sponsored by the Department of Defense (DoD) Space Test Program.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, construction workers assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, has been installed on the south side of the high bay. In view below are several levels of previously installed platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

DETAIL VIEW OF SRB/ET ACCESS PANELS, THROUGH VEHICLE ACCESS PLATFORMS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF SRB/ET ACCESS PANELS, THROUGH VEHICLE ACCESS PLATFORMS E-NORTH, E-SOUTH, B-NORTH, AND B-SOUTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

The evolution of location and data collection systems in the United States.

NASA Technical Reports Server (NTRS)

Morakis, J. C.; Cote, C. E.

1973-01-01

Satellite location and data collection systems development began in the early 1960's in NASA and the French CNES. These systems were initially developed for application to meteorology and oceanography as a means of tracking moving platforms on a global scale. Additional applications such as geology, hydrology, and ecology have since evolved. To date, five successful missions have been completed. With each successive launch, systems improved in accordance with user requirements - particularly reduction in cost and complexity of platform equipment. With planned launches, facilities will be available to the user community through 1980; NASA is currently forecasting needs beyond 1980.

DLR HABLEG- High Altitude Balloon Launched Experimental Glider

NASA Astrophysics Data System (ADS)

Wlach, S.; Schwarzbauch, M.; Laiacker, M.

2015-09-01

The group Flying Robots at the DLR Institute of Robotics and Mechatronics in Oberpfaffenhofen conducts research on solar powered high altitude aircrafts. Due to the high altitude and the almost infinite mission duration, these platforms are also denoted as High Altitude Pseudo-Satellites (HAPS). This paper highlights some aspects of the design, building, integration and testing of a flying experimental platform for high altitudes. This unmanned aircraft, with a wingspan of 3 m and a mass of less than 10 kg, is meant to be launched as a glider from a high altitude balloon in 20 km altitude and shall investigate technologies for future large HAPS platforms. The aerodynamic requirements for high altitude flight included the development of a launch method allowing for a safe transition to horizontal flight from free-fall with low control authority. Due to the harsh environmental conditions in the stratosphere, the integration of electronic components in the airframe is a major effort. For regulatory reasons a reliable and situation dependent flight termination system had to be implemented. In May 2015 a flight campaign was conducted. The mission was a full success demonstrating that stratospheric research flights are feasible with rather small aircrafts.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lowers the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, for installation on the south side of High Bay 3 in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Cubesats: Cost-effective science and technology platforms for emerging and developing nations

NASA Astrophysics Data System (ADS)

Woellert, Kirk; Ehrenfreund, Pascale; Ricco, Antonio J.; Hertzfeld, Henry

2011-02-01

The development, operation, and analysis of data from cubesats can promote science education and spur technology utilization in emerging and developing nations. This platform offers uniquely low construction and launch costs together with a comparative ubiquity of launch providers; factors that have led more than 80 universities and several emerging nations to develop programs in this field. Their small size and weight enables cubesats to “piggyback” on rocket launches and accompany orbiters travelling to Moon and Mars. It is envisaged that constellations of cubesats will be used for larger science missions. We present a brief history, technology overview, and summary of applications in science and industry for these small satellites. Cubesat technical success stories are offered along with a summary of pitfalls and challenges encountered in both developed and emerging nations. A discussion of economic and public policy issues aims to facilitate the decision-making process for those considering utilization of this unique technology.

A fresh look at functional link neural network for motor imagery-based brain-computer interface.

PubMed

Hettiarachchi, Imali T; Babaei, Toktam; Nguyen, Thanh; Lim, Chee P; Nahavandi, Saeid

2018-05-04

Artificial neural networks (ANNs) are one of the widely used classifiers in the brain-computer interface (BCI) systems-based on noninvasive electroencephalography (EEG) signals. Among the different ANN architectures, the most commonly applied for BCI classifiers is the multilayer perceptron (MLP). When appropriately designed with optimal number of neuron layers and number of neurons per layer, the ANN can act as a universal approximator. However, due to the low signal-to-noise ratio of EEG signal data, overtraining problem may become an inherent issue, causing these universal approximators to fail in real-time applications. In this study we introduce a higher order neural network, namely the functional link neural network (FLNN) as a classifier for motor imagery (MI)-based BCI systems, to remedy the drawbacks in MLP. We compare the proposed method with competing classifiers such as linear decomposition analysis, naïve Bayes, k-nearest neighbours, support vector machine and three MLP architectures. Two multi-class benchmark datasets from the BCI competitions are used. Common spatial pattern algorithm is utilized for feature extraction to build classification models. FLNN reports the highest average Kappa value over multiple subjects for both the BCI competition datasets, under similarly preprocessed data and extracted features. Further, statistical comparison results over multiple subjects show that the proposed FLNN classification method yields the best performance among the competing classifiers. Findings from this study imply that the proposed method, which has less computational complexity compared to the MLP, can be implemented effectively in practical MI-based BCI systems. Copyright © 2018 Elsevier B.V. All rights reserved.

Smart management of sample dilution using an artificial neural network to achieve streamlined processes and saving resources: the automated nephelometric testing of serum free light chain as case study.

PubMed

Ialongo, Cristiano; Pieri, Massimo; Bernardini, Sergio

2017-02-01

Saving resources is a paramount issue for the modern laboratory, and new trainable as well as smart technologies can be used to allow the automated instrumentation to manage samples more efficiently in order to achieve streamlined processes. In this regard the serum free light chain (sFLC) testing represents an interesting challenge, as it usually causes using a number of assays before achieving an acceptable result within the analytical range. An artificial neural network based on the multi-layer perceptron (MLP-ANN) was used to infer the starting dilution status of sFLC samples based on the information available through the laboratory information system (LIS). After the learning phase, the MLP-ANN simulation was applied to the nephelometric testing routinely performed in our laboratory on a BN ProSpec® System analyzer (Siemens Helathcare) using the N Latex FLC kit. The MLP-ANN reduced the serum kappa free light chain (κ-FLC) and serum lambda free light chain (λ-FLC) wasted tests by 69.4% and 70.8% with respect to the naïve stepwise dilution scheme used by the automated analyzer, and by 64.9% and 66.9% compared to a "rational" dilution scheme based on a 4-step dilution. Although it was restricted to follow-up samples, the MLP-ANN showed good predictive performance, which alongside the possibility to implement it in any automated system, made it a suitable solution for achieving streamlined laboratory processes and saving resources.

A screening system for smear-negative pulmonary tuberculosis using artificial neural networks.

PubMed

de O Souza Filho, João B; de Seixas, José Manoel; Galliez, Rafael; de Bragança Pereira, Basilio; de Q Mello, Fernanda C; Dos Santos, Alcione Miranda; Kritski, Afranio Lineu

2016-08-01

Molecular tests show low sensitivity for smear-negative pulmonary tuberculosis (PTB). A screening and risk assessment system for smear-negative PTB using artificial neural networks (ANNs) based on patient signs and symptoms is proposed. The prognostic and risk assessment models exploit a multilayer perceptron (MLP) and inspired adaptive resonance theory (iART) network. Model development considered data from 136 patients with suspected smear-negative PTB in a general hospital. MLP showed higher sensitivity (100%, 95% confidence interval (CI) 78-100%) than the other techniques, such as support vector machine (SVM) linear (86%; 95% CI 60-96%), multivariate logistic regression (MLR) (79%; 95% CI 53-93%), and classification and regression tree (CART) (71%; 95% CI 45-88%). MLR showed a slightly higher specificity (85%; 95% CI 59-96%) than MLP (80%; 95% CI 54-93%), SVM linear (75%, 95% CI 49-90%), and CART (65%; 95% CI 39-84%). In terms of the area under the receiver operating characteristic curve (AUC), the MLP model exhibited a higher value (0.918, 95% CI 0.824-1.000) than the SVM linear (0.796, 95% CI 0.651-0.970) and MLR (0.782, 95% CI 0.663-0.960) models. The significant signs and symptoms identified in risk groups are coherent with clinical practice. In settings with a high prevalence of smear-negative PTB, the system can be useful for screening and also to aid clinical practice in expediting complementary tests for higher risk patients. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Antiobesity effect of polyphenolic compounds from molokheiya (Corchorus olitorius L.) leaves in LDL receptor-deficient mice.

PubMed

Wang, Li; Yamasaki, Masayuki; Katsube, Takuya; Sun, Xufeng; Yamasaki, Yukikazu; Shiwaku, Kuninori

2011-03-01

Dietary supplementation with polyphenolic compounds is associated with reduced diet-induced obesity and metabolic disorders in humans. The antioxidative properties of polyphenolic compounds contribute to their antiobesity effect in animal experiments and human studies. The aim of the study was to investigate the antiobesity effect of polyphenolic compounds from molokheiya leaves in LDLR-/- mice fed high-fat diet and to elucidate the mechanism of this effect. Three groups of LDLR-/- mice were fed with a high-fat diet, supplemented with 0% (control), 1 or 3% molokheiya leaf powder (MLP). Gene expression in the liver associated with lipid and glucose metabolism was analyzed, and physical parameters and blood biochemistry were determined. Compared to controls, mice body weight gain (P = 0.003), liver weight (P = 0.001) and liver triglyceride levels (P = 0.005) were significantly lower in the two MLP groups. Epididymal adipose tissue weight (P = 0.003) was reduced in the 3% MLP group. Liver tissue gene expression of gp91phox (NOX2), involved in oxidative stress, was significantly down-regulated (P = 0.005), and PPARα and CPT1A, related to the activation of β-oxidation, were significantly up-regulated (P = 0.025 and 0.006, respectively) in the 3% MLP group compared to the control group. Our results demonstrate an antiobesity effect of polyphenolic compounds from molokheiya leaves and that this effect is associated with reduction in oxidative stress and enhancement of β-oxidation in the liver. Consumption of molokheiya leaves may be beneficial for preventing diet-induced obesity.

Air Launch: Examining Performance Potential of Various Configurations and Growth Options

NASA Technical Reports Server (NTRS)

Waters, Eric D.; Creech, Dennis M.; Philips, Alan

2013-01-01

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a high-level analysis of various air launch vehicle configurations, objectively determining maximum launch vehicle payload while considering carrier aircraft capabilities and given dimensional constraints. With the renewed interest in aerial launch of low-earth orbit payloads, referenced by programs such as Stratolaunch and Spaceship2, there existed a need to qualify the boundaries of the trade space, identify performance envelopes, and understand advantages and limiting factors of designing for maximum payload capability. Using the NASA/DARPA Horizontal Launch Study (HLS) Point Design 2 (PD-2) as a point-of-departure configuration, two independent design actions were undertaken. Both configurations utilized a Boeing 747-400F as the carrier aircraft, LOX/RP-1 first stage and LOX/LH2 second stage. Each design was sized to meet dimensional and mass constraints while optimizing propellant loads and stage delta V (?V) splits. All concepts, when fully loaded, exceeded the allowable Gross Takeoff Weight (GTOW) of the aircraft platform. This excess mass was evaluated as propellant/fuel offload available for a potential in-flight refueling scenario. Results indicate many advantages such as large, relative payload delivery of approximately 47,000 lbm and significant mission flexibility, such as variable launch site inclination and launch window; however, in-flight cryogenic fluid transfer and carrier aircraft platform integration are substantial technical hurdles to the realization of such a system configuration.

Cardiac Arrhythmia Classification by Multi-Layer Perceptron and Convolution Neural Networks.

PubMed

Savalia, Shalin; Emamian, Vahid

2018-05-04

The electrocardiogram (ECG) plays an imperative role in the medical field, as it records heart signal over time and is used to discover numerous cardiovascular diseases. If a documented ECG signal has a certain irregularity in its predefined features, this is called arrhythmia, the types of which include tachycardia, bradycardia, supraventricular arrhythmias, and ventricular, etc. This has encouraged us to do research that consists of distinguishing between several arrhythmias by using deep neural network algorithms such as multi-layer perceptron (MLP) and convolution neural network (CNN). The TensorFlow library that was established by Google for deep learning and machine learning is used in python to acquire the algorithms proposed here. The ECG databases accessible at PhysioBank.com and kaggle.com were used for training, testing, and validation of the MLP and CNN algorithms. The proposed algorithm consists of four hidden layers with weights, biases in MLP, and four-layer convolution neural networks which map ECG samples to the different classes of arrhythmia. The accuracy of the algorithm surpasses the performance of the current algorithms that have been developed by other cardiologists in both sensitivity and precision.

Prediction of S-wave velocity using complete ensemble empirical mode decomposition and neural networks

NASA Astrophysics Data System (ADS)

Gaci, Said; Hachay, Olga; Zaourar, Naima

2017-04-01

One of the key elements in hydrocarbon reservoirs characterization is the S-wave velocity (Vs). Since the traditional estimating methods often fail to accurately predict this physical parameter, a new approach that takes into account its non-stationary and non-linear properties is needed. In this view, a prediction model based on complete ensemble empirical mode decomposition (CEEMD) and a multiple layer perceptron artificial neural network (MLP ANN) is suggested to compute Vs from P-wave velocity (Vp). Using a fine-to-coarse reconstruction algorithm based on CEEMD, the Vp log data is decomposed into a high frequency (HF) component, a low frequency (LF) component and a trend component. Then, different combinations of these components are used as inputs of the MLP ANN algorithm for estimating Vs log. Applications on well logs taken from different geological settings illustrate that the predicted Vs values using MLP ANN with the combinations of HF, LF and trend in inputs are more accurate than those obtained with the traditional estimating methods. Keywords: S-wave velocity, CEEMD, multilayer perceptron neural networks.

Inhibition of polymorphonuclear leukocyte function by Legionella pneumophila exoproducts.

PubMed

Sahney, N N; Lambe, B C; Summersgill, J T; Miller, R D

1990-08-01

Total exoproducts (relative molecular mass greater than 10,000) from wild-type strains of Legionella pneumophila markedly inhibited human polymorphonuclear leukocyte (PMN) superoxide anion generation, at sub-lethal concentrations, in response to four stimuli [1.7, 0, 0.6 and 3.4% of control for zymosan activated particles (ZAP), phorbol myristate acetate (PMA), calcium ionophore (A 23187), and formyl-methionyl-leucyl-phenylalanine (fMLP), respectively]. PMN chemotaxis towards fMLP and spontaneous migration, were also dramatically inhibited (2.8 and 2.9% of buffer-treated controls, respectively). In contrast, total exoproducts from the cas-1 strain of L. pneumophila, a protease-deficient mutant generated by ethyl methane sulfonate mutagenesis, failed to inhibit PMN superoxide production in response to ZAP and PMA and only partially inhibited PMN response to A 23187 and fMLP. PMN spontaneous migration was unaffected by treatment with total exoproducts from the mutant, while directed chemotaxis was partially inhibited (51.4%). These data demonstrated that L. pneumophila total exoproducts, primarily protease had significant inhibitory effects on normal PMN function and may play an important contributory role in the pathogenesis of legionnaire's disease.

Kennedy Space Center: Creating a Spaceport Reality from the Dreams of Many

NASA Technical Reports Server (NTRS)

Gray, James A.; Colloredo, Scott

2012-01-01

On December 17, 1903, Orville Wright piloted the first powered airplane only 20 feet above the ground near Kitty Hawk, North Carolina. The flight lasted 12 seconds and covered 120 feet. Who would have guessed that the bizarre looking contraption developed by brothers in the bicycle business would lay the ground work eventually resulting in over a million passengers moved daily in a sky filled with the contrails of jets flying at over 30,000 feet in elevation and over 500 miles per hour. Similarly, who would have guessed that the destructive nature of V-2 rockets of Germany would spark the genesis of spaceflight to explore our solar system and beyond? Yet the interest in using the Kennedy Space Center (KSC) continues to grow. Potential customers have expressed interest in KSC as a location for testing new rocket engines, servicing the world's largest airborne launching platform for drop-launch rockets, developing multi-use launch platforms that permit diverse customers to use the same launch platform, developing new spacecraft, and implementing advanced modifications for lifting 150 metric ton payloads to low earth orbit. The multitude of customers has grown and with this growth comes a need to provide a command, control, communication, and range infrastructure that maximizes flexibility and reconfigurability to address a much more frequent launch rate of diverse vehicles and spacecraft. The Ground Systems Development and Operations (GSDO) Program Office at KSC is embarking upon these developments to realize the dream of a robust spaceport. Many unique technical trade studies have been completed or are underway to successfully transition KSC into a multi-user customer focused spaceport. Like the evolution of the airplane, GSDO is working to transform KSC infrastructures that will turn once unthinkable space opportunities into a reality for today.

A Comparison of Platforms for the Aerial Exploration of Titan

NASA Technical Reports Server (NTRS)

Wright, Henry S.; Gasbarre, Joseph F.; Levine, Joel S.

2005-01-01

Exploration of Titan, envisioned as a follow-on to the highly successful Cassini-Huygens mission, is described in this paper. A mission blending measurements from a dedicated orbiter and an in-situ aerial explorer is discussed. Summary description of the science rationale and the mission architecture, including the orbiter, is provided. The mission has been sized to ensure it can be accommodated on an existing expendable heavy-lift launch vehicle. A launch to Titan in 2018 with a 6-year time of flight to Titan using a combination of Solar Electric Propulsion and aeroassist (direct entry and aerocapture) forms the basic mission architecture. A detailed assessment of different platforms for aerial exploration of Titan has been performed. A rationale for the selection of the airship as the baseline platform is provided. Detailed description of the airship, its subsystems, and its operational strategies are provided.

Space Based Intelligence, Surveillance, and Reconnaissance Contribution to Global Strike in 2035

DTIC Science & Technology

2012-02-15

include using high altitude air platforms and airships as a short-term solution, and small satellites with an Operationally Responsive Space (ORS) launch...irreversible threats, along with a worst case scenario. Section IV provides greater detail of the high altitude air platform, airship , and commercial space...Resultantly, the U.S. could use high altitude air platforms, airships , and cyber to complement its space systems in case of denial, degradation, or

Cabana Multi-User Spaceport Tour of KSC

NASA Image and Video Library

2017-02-17

Members of the news media view the 10 levels of new work platforms in High Bay 3 inside the Vehicle Assembly Building (VAB) during a tour of NASA's Kennedy Space Center in Florida with Center Director Bob Cabana. The final platform, A north, was recently installed. The platforms will surround the Space Launch System and Orion spacecraft on the mobile launcher during processing to prepare for the first test flight. The Ground Systems Development and Operations Program is overseeing upgrades to the VAB, including installation of the new work platforms.

STS-112 Pilot Melroy suits up for launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-112 Pilot Pamela Melroy finishes suiting up for launch. STS-112 is the 15th assembly flight to the International Space Station, carrying the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station. Launch is scheduled for 3:46 p.m. EDT from Launch Pad 39B. .

STS-112 M.S. Magnus suits up before launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-112 Mission Specialist Sandra Magnus finishes suiting up before launch. STS-112 is the 15th assembly flight to the International Space Station, carrying the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station. Launch is scheduled for 3:46 p.m. EDT from Launch Pad 39B.

KSC-2012-1679

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians begin the work to secure a new engine and generator inside crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1670

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, new engines and generators have arrived for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1680

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians begin the work to secure a new engine and generator inside crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1343

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians prepare an Apollo era diesel engine inside crawler-transporter 2 CT-2) for removal. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1671

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a new engine and generator have arrived for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1672

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians prepare a new engine and generator for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lowers the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, into High Bay 3 of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. In view below are several of the previously installed levels of platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the south wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a construction worker assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Photography by KSC Space Shuttle Orbiter Enterprise mated to an external fuel tank and two solid

NASA Technical Reports Server (NTRS)

1980-01-01

Photography by KSC Space Shuttle Orbiter Enterprise mated to an external fuel tank and two solid rocket boosters on top of a Mobil Launcher Platform, undergoes fit and function checks at the launch site for the first Space Shuttle at Launch Complex 39's Pad A. The dummy Space Shuttle was assembled in the Vehicle Assembly Building and rolled out to the launch site on May 1 as part of an exercise to make certain shuttle elements are compatible with the Spaceport's assembly and launch facilities and ground support equipment, and help clear the way for the launch of the Space Shuttle Orbiter Columbia.

PHOTOGRAPHY BY KSC SPACE SHUTTLE ORBITER ENTERPRISE MATED TO AN EXTERNAL FUEL TANK AND TWO SOLID

NASA Technical Reports Server (NTRS)

1980-01-01

PHOTOGRAPHY BY KSC SPACE SHUTTLE ORBITER ENTERPRISE MATED TO AN EXTERNAL FUEL TANK AND TWO SOLID ROCKET BOOSTERS ON TOP OF A MOBIL LAUNCHER PLATFORM, UNDERGOES FIT AND FUNCTION CHECKS AT THE LAUNCH SITE FOR THE FIRST SPACE SHUTTLE AT LAUNCH COMPLEX 39'S PAD A. THE DUMMY SPACE SHUTTLE WAS ASSEMBLED IN THE VEHICLE ASSEMBLY BUILDING AND ROLLED OUT TO THE LAUNCH SITE ON MAY 1 AS PART OF AN EXERCISE TO MAKE CERTAIN SHUTTLE ELEMENTS ARE COMPATIBLE WITH THE SPACEPORT'S ASSEMBLY AND LAUNCH FACILITIES AND GROUND SUPPORT EQUIPMENT, AND HELP CLEAR THE WAY FOR THE LAUNCH OF THE SPACE SHUTTLE ORBITER COLUMBIA.

Challenge '95 - The Ariane 5 Development Programme

NASA Astrophysics Data System (ADS)

Vedrenne, M.; van Gaver, M.

1987-10-01

The Ariane-5 launcher has been assigned to the following types of missions: (1) launching geostationary and sun-synchronous commercial satellites, and scientific and trial applications satellites; (2) launching the Hermes spaceplane, and (3) launching elements of the Columbus system such as the man-tended free-flyer module, and the polar platform. A new launch complex, the ELA-3, is being built for the Ariane-5 launcher close to ESA's ELA-1 and ELA-2 launch complexes at Kourou. After two qualification flights in the automatic version in 1995 (501 and 502), it is expected that Ariane-5 will be declared operational with its first commercial flight planned for early 1996 to put an automatic payload into orbit.

A Cubesat Asteroid Mission: Propulsion Trade-offs

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.; Oleson, Steven R.; McGuire, Melissa L.; Bur, Michael J.; Burke, Laura M.; Fittje, James E.; Kohout, Lisa L.; Fincannon, James; Packard, Thomas W.; Martini, Michael C.

2014-01-01

A conceptual design was performed for a 6-U cubesat for a technology demonstration to be launched on the NASA Space Launch System (SLS) test launch EM-1, to be launched into a free-return translunar trajectory. The mission purpose was to demonstrate use of electric propulsion systems on a small satellite platform. The candidate objective chosen was a mission to visit a Near-Earth asteroid. Both asteroid fly-by and asteroid rendezvous missions were analyzed. Propulsion systems analyzed included cold-gas thruster systems, Hall and ion thrusters, incorporating either Xenon or Iodine propellant, and an electrospray thruster. The mission takes advantage of the ability of the SLS launch to place it into an initial trajectory of C3=0.

STS-27 Atlantis, Orbiter Vehicle (OV) 104, at KSC Launch Complex (LC) pad 39B

NASA Technical Reports Server (NTRS)

1988-01-01

STS-27 Atlantis, Orbiter Vehicle (OV) 104, sits atop the mobile launcher platform at Kennedy Space Center (KSC) Launch Complex (LC) pad 39B. Profile of OV-104 mounted on external tank and flanked by solid rocket boosters (SRBs) is obscured by a flock of seagulls in the foreground. The fixed service structure (FSS) with rotating service structure (RSS) retracted appears in the background. Water resevoir is visible at the base of the launch pad concrete structure.

STS-107 Columbia rollout to Launch Pad 39A

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia, framed by trees near the Banana River, rolls towards Launch Pad 39A, sitting atop the Mobile Launcher Platform, which in turn is carried by the crawler-transporter underneath. The STS-107 research mission comprises experiments ranging from material sciences to life sciences (many rats), plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.

Development and Testing of an Engineering Prototype for a Marine Version of the Berkeley Unexploded Ordnance Discriminator (BUD)

DTIC Science & Technology

2013-06-01

on the laminated waterproof platform as shown in Figures 29 and 30. 35 Figure 29 Figure 30 36 The receiver coils, and transmitter...mounted on a flatbed trailer, transported to the Richmond Marina, and launched from the boat launch ramp, Figure 32. 37 Figure 32 Once in

KSC-02pd1894

NASA Image and Video Library

2002-12-09

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Columbia sits on Launch Pad 39A, atop the Mobile Launcher Platform. The STS-107 research mission comprises experiments ranging from material sciences to life sciences, plus the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. Mission STS-107 is scheduled to launch Jan. 16, 2003.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Arrival

NASA Image and Video Library

2016-08-30

A section of the second half of the C-level platforms, C North, for NASA’s Space Launch System (SLS) rocket, arrives at the agency’s Kennedy Space Center in Florida. The platform was offloaded from a heavy lift transport truck and secured in a staging area in the west parking lot of the Vehicle Assembly Building (VAB). The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

(abstract) Tropospheric Emission Spectrometer (TES)

NASA Technical Reports Server (NTRS)

Beer, Reinhard

1994-01-01

A descope of the EOS program now requires that all EOS platforms after AM1 be launched on DELTA-class vehicles, which results in much smaller platforms (and payloads) than previously envisaged. A major part of the TES hardware design effort has therefore been redirected towards meeting this challenge. The development of the TES concept continues on a schedule to permit flight on the EOS CHEM platform in 2002, where it is planned to be accompanied by HIRDLS and MLS.

Prompt inhibition of fMLP-induced Ca2+ mobilization by parenteral lipid emulsions in human neutrophils.

PubMed

Wanten, Geert; Rops, Angelique; van Emst-De Vries, Sjenet E; Naber, Ton; Willems, Peter H G M

2002-04-01

It remains unclear whether modulation of immune system functions by lipids contributes to the increased infection rate observed in patients treated with parenteral nutrition. We therefore evaluated the effects of lipid emulsions derived from fish oil [very long chain triglycerides (VLCT)], olive oil [long-chain triglycerides- mono-unsaturated fatty acid (LCT-MUFA)], soya oil [long-chain triglycerides (LCT)], or a physical mixture of coconut and soya oil [mixed long- and medium-chain triglycerides (LCT-MCT)] on neutrophil activation. N-formyl-methionyl-leucyl-phenylalanine (fMLP) evoked an immediate increase of the cytosolic Ca2+ concentration ([Ca2+](i,av)) in a suspension of neutrophils. When added 3 min before fMLP, however, all four lipid emulsions reduced the hormone-induced increase in [Ca2+](i,av) with the same efficacy but with different potency. Half-maximal inhibition was reached at emulsion concentrations of 0.24 mM VLCT, 0.32 mM LCT-MCT, 0.52 mM LCT, and 0.82 mM LCT-MUFA. Similarly to the lipids, the protein kinase C (PKC) activator PMA markedly reduced the fMLP-induced increase in [Ca2+](i,av). PMA inhibition was abolished by the PKC inhibitor staurosporine. In contrast, however, this drug did not interfere with the inhibitory lipid effect, indicating that the lipids act primarily in a PKC-independent manner. In summary, this study shows that nutritional lipids can evoke a prompt and significant attenuation of hormone-induced neutrophil stimulation and that the emulsions based on fish oil and a mixture of coconut oil and soya oil are among the most potent ones in this respect.

Analyzing signal attenuation in PFG anomalous diffusion via a non-Gaussian phase distribution approximation approach by fractional derivatives.

PubMed

Lin, Guoxing

2016-11-21

Anomalous diffusion exists widely in polymer and biological systems. Pulsed-field gradient (PFG) techniques have been increasingly used to study anomalous diffusion in nuclear magnetic resonance and magnetic resonance imaging. However, the interpretation of PFG anomalous diffusion is complicated. Moreover, the exact signal attenuation expression including the finite gradient pulse width effect has not been obtained based on fractional derivatives for PFG anomalous diffusion. In this paper, a new method, a Mainardi-Luchko-Pagnini (MLP) phase distribution approximation, is proposed to describe PFG fractional diffusion. MLP phase distribution is a non-Gaussian phase distribution. From the fractional derivative model, both the probability density function (PDF) of a spin in real space and the PDF of the spin's accumulating phase shift in virtual phase space are MLP distributions. The MLP phase distribution leads to a Mittag-Leffler function based PFG signal attenuation, which differs significantly from the exponential attenuation for normal diffusion and from the stretched exponential attenuation for fractional diffusion based on the fractal derivative model. A complete signal attenuation expression E α (-D f b α,β * ) including the finite gradient pulse width effect was obtained and it can handle all three types of PFG fractional diffusions. The result was also extended in a straightforward way to give a signal attenuation expression of fractional diffusion in PFG intramolecular multiple quantum coherence experiments, which has an n β dependence upon the order of coherence which is different from the familiar n 2 dependence in normal diffusion. The results obtained in this study are in agreement with the results from the literature. The results in this paper provide a set of new, convenient approximation formalisms to interpret complex PFG fractional diffusion experiments.

Small median tumor diameter at cure threshold (<20 mm) among aggressive non-small cell lung cancers in male smokers predicts both chest X-ray and CT screening outcomes in a novel simulation framework.

PubMed

Goldwasser, Deborah L; Kimmel, Marek

2013-01-01

The effectiveness of population-wide lung cancer screening strategies depends on the underlying natural course of lung cancer. We evaluate the expected stage distribution in the Mayo CT screening study under an existing simulation model of non-small cell lung cancer (NSCLC) progression calibrated to the Mayo lung project (MLP). Within a likelihood framework, we evaluate whether the probability of 5-year NSCLC survival conditional on tumor diameter at detection depends significantly on screening detection modality, namely chest X-ray and computed tomography. We describe a novel simulation framework in which tumor progression depends on cellular proliferation and mutation within a stem cell compartment of the tumor. We fit this model to randomized trial data from the MLP and produce estimates of the median radiologic size at the cure threshold. We examine the goodness of model fit with respect to radiologic tumor size and 5-year NSCLC survival among incident cancers in both the MLP and Mayo CT studies. An existing model of NSCLC progression under-predicts the number of advanced-stage incident NSCLCs among males in the Mayo CT study (p-value = 0.004). The probability of 5-year NSCLC survival conditional on tumor diameter depends significantly on detection modality (p-value = 0.0312). In our new model, selected solution sets having a median tumor diameter of 16.2-22.1 mm at cure threshold among aggressive NSCLCs predict both MLP and Mayo CT outcomes. We conclude that the median lung tumor diameter at cure threshold among aggressive NSCLCs in male smokers may be small (<20 mm). Copyright © 2012 UICC.

Can a video curriculum on the social determinants of health affect residents' practice and families' perceptions of care?

PubMed

Klein, Melissa D; Alcamo, Alicia M; Beck, Andrew F; O'Toole, Jennifer K; McLinden, Daniel; Henize, Adrienne; Kahn, Robert S

2014-01-01

Screening and management of the social determinants of health (SDH) are critical for child health promotion. We sought to evaluate the impact of a facilitated video curriculum on resident SDH screening competence, parental perceptions of resident practice, resident-initiated referrals to a medical-legal partnership (MLP), and formula distribution to food-insecure families. This was a pre-post study with concurrent control performed at a large pediatric residency program. Second- and third-year residents were assigned to control and intervention groups on the basis of their continuity clinic day. The curriculum included videotaped vignettes of screening for SDH and a "day in the life" series of families describing the impact of intervention on their lives. Residents completed self-assessments on screening competence and resource knowledge. After a well-child encounter, families (3 per resident) assessed their level of trust and respect for the resident and the number of SDHs screened for. MLP referral rates and formula distribution were compared. The intervention group's self-assessed competence in screening for housing, benefits, and educational concerns was significantly higher compared to controls (each P ≤ .05). Parents' rating of trust and respect was high and did not differ between groups. Screening for each SDH was higher in the intervention group with domestic violence (odds ratio 2.16, 95% confidence interval 1.01-4.63) and depression (odds ratio 2.63, 95% confidence interval 1.15-5.99), reaching statistical significance. MLP referral rates increased (P = .06), and formula distribution (P = .02) reached statistical significance in the intervention group. This SDH video curriculum improved resident self-assessed screening competence, parental perception of screening, and both MLP referrals and formula distribution. Copyright © 2014 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

The control of neutrophil chemotaxis by inhibitors of cathepsin G and chymotrypsin.

PubMed

Lomas, D A; Stone, S R; Llewellyn-Jones, C; Keogan, M T; Wang, Z M; Rubin, H; Carrell, R W; Stockley, R A

1995-10-06

Neutrophil chemotaxis plays an important role in the inflammatory response and when excessive or persistent may augment tissue damage. The effects of inhibitors indicated the involvement of one or more serine proteinases in human neutrophil migration and shape change in response to a chemoattractant. Monospecific antibodies, chloromethylketone inhibitors, and reactive-site mutants of alpha 1-antitrypsin and alpha 1-antichymotrypsin were used to probe the specificity of the proteinases involved in chemotaxis. Antibodies specific for cathepsin G inhibited chemotaxis. Moreover, rapid inhibitors of cathepsin G and alpha-chymotrypsin suppressed neutrophil chemotaxis to the chemoattractants N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and zymosan-activated serum in multiple blind well assays and to fMLP in migration assays under agarose. The concentrations of antichymotrypsin mutants that reduced chemotaxis by 50% would inactivate free cathepsin G with a half-life of 1.5-3 s, whereas the concentrations of chloromethylketones required to produce a similar inhibition of chemotaxis would inactivate cathepsin G with a half-life of 345 s. These data suggest different modes of action for these two classes of inhibitors. Indeed the chloromethylketone inhibitors of cathepsin G (Z-Gly-Leu-Phe-CMK) and to a lesser extent of chymotrypsin (Cbz-Gly-Gly-Phe-CMK) mediated their effect by preventing a shape change in the purified neutrophils exposed to fMLP. Antichymotrypsin did not affect shape change in response to fMLP even at concentrations that were able to reduce neutrophil chemotaxis by 50%. These results support the involvement of cell surface proteinases in the control of cell migration and show that antichymotrypsin and chloromethylketones have differing modes of action. This opens the possibility for the rational design of anti-inflammatory agents targeted at neutrophil membrane enzymes.

Aeolian dust supply from the Yellow River floodplain to the Pleistocene loess deposits of the Mangshan Plateau, central China: Evidence from zircon U-Pb age spectra

NASA Astrophysics Data System (ADS)

Shang, Yuan; Prins, Maarten A.; Beets, Christiaan J.; Kaakinen, Anu; Lahaye, Yann; Dijkstra, Noortje; Rits, Daniël S.; Wang, Bin; Zheng, Hongbo; van Balen, Ronald T.

2018-02-01

The thick loess-palaeosol sequences in the Mangshan Loess Plateau (MLP; central China) along the south bank of the lower reach of the Yellow River provide high-resolution records of Quaternary climate change. In addition, substantial increases in grain-size and accumulation rate have been inferred in the upper part of the loess sequence, above palaeosol layer S2. This study investigates the sources of the long-term dust supply to the MLP and explores the mechanism behind the sudden increase in sediment delivery and coarsening of the loess deposits since S2 (∼240 ka) by using end member modelling of the loess grain-size dataset and single-grain zircon U-Pb dating. Our results indicate that the lower Yellow River floodplain, directly north of the MLP, served as a major dust supply for the plateau at least since the deposition of loess unit L9 and indirectly suggest that the integration of the Yellow River and the disappearance of the Sanmen palaeolake took place before L9 (∼900 ka). The sudden change in sedimentology of the Mangshan sequence above palaeosol unit S2 may result from an increased fluvial sediment flux being transported to the lower reaches of the Yellow River because of tectonic movements (initiated) in the Weihe Basin around 240 ka. Furthermore, sediment coarsening can be explained by the gradual southward migration of the lower Yellow River floodplain towards the MLP since the deposition of palaeosol S2. The migration is evidenced by the formation of an impressive scarp, and is likely caused by tectonic tilting of the floodplain area.

Landslide susceptibility assesssment in the Uttarakhand area (India) using GIS: a comparison study of prediction capability of naïve bayes, multilayer perceptron neural networks, and functional trees methods

NASA Astrophysics Data System (ADS)

Pham, Binh Thai; Tien Bui, Dieu; Pourghasemi, Hamid Reza; Indra, Prakash; Dholakia, M. B.

2017-04-01

The objective of this study is to make a comparison of the prediction performance of three techniques, Functional Trees (FT), Multilayer Perceptron Neural Networks (MLP Neural Nets), and Naïve Bayes (NB) for landslide susceptibility assessment at the Uttarakhand Area (India). Firstly, a landslide inventory map with 430 landslide locations in the study area was constructed from various sources. Landslide locations were then randomly split into two parts (i) 70 % landslide locations being used for training models (ii) 30 % landslide locations being employed for validation process. Secondly, a total of eleven landslide conditioning factors including slope angle, slope aspect, elevation, curvature, lithology, soil, land cover, distance to roads, distance to lineaments, distance to rivers, and rainfall were used in the analysis to elucidate the spatial relationship between these factors and landslide occurrences. Feature selection of Linear Support Vector Machine (LSVM) algorithm was employed to assess the prediction capability of these conditioning factors on landslide models. Subsequently, the NB, MLP Neural Nets, and FT models were constructed using training dataset. Finally, success rate and predictive rate curves were employed to validate and compare the predictive capability of three used models. Overall, all the three models performed very well for landslide susceptibility assessment. Out of these models, the MLP Neural Nets and the FT models had almost the same predictive capability whereas the MLP Neural Nets (AUC = 0.850) was slightly better than the FT model (AUC = 0.849). The NB model (AUC = 0.838) had the lowest predictive capability compared to other models. Landslide susceptibility maps were final developed using these three models. These maps would be helpful to planners and engineers for the development activities and land-use planning.

Superselective Thalamotomy in the Most Lateral Part of the Ventralis Intermedius Nucleus for Controlling Essential and Parkinsonian Tremor.

PubMed

Hirato, Masafumi; Miyagishima, Takaaki; Takahashi, Akio; Yoshimoto, Yuhei

2018-01-01

The minimum and essential thalamic areas for reducing tremor were investigated in cases treated by superselective thalamotomy in the most lateral part of the ventralis intermedius nucleus (mlp-VIM). Stereotactic superselective VIM thalamotomy with depth microrecording was performed in 21 patients with essential tremor (ET) and 15 patients with tremor-dominant Parkinson disease (PD). A very small and narrow (axial plane) therapeutic lesion was formed as a square on the sagittal plane and inverse V on the axial plane in the mlp-VIM, which covered the kinesthetic response area topographically related to tremor. Patients with ET were followed up for 4.7 ± 3.0 years and patients with PD for 7.9 ± 3.9 years. Almost complete tremor control was achieved in all patients immediately after surgery and continued for up to 8 years. A few adverse events were recognized but disappeared within 1 month without 1 patient with thalamic hemorrhage. The medial border of the therapeutic lesion was significantly more lateral in both patients with ET and patients with PD than the calculated standard target point and was in patients with PD than in patients with ET. The mean width was only about 2.4 mm. The individual differences of the adequate location of the therapeutic lesion were significantly greater in the ET than in the PD group. The important area for reducing tremor was small and narrow and was located in the mlp-VIM, where the proprioceptive ascending signals from the tremor-dominant body part are conducted. Superselective thalamotomy in the mlp-VIM was safe and effective for the long-term in patients with ET and PD. Copyright © 2017 Elsevier Inc. All rights reserved.

Predicting prolonged length of hospital stay in older emergency department users: use of a novel analysis method, the Artificial Neural Network.

PubMed

Launay, C P; Rivière, H; Kabeshova, A; Beauchet, O

2015-09-01

To examine performance criteria (i.e., sensitivity, specificity, positive predictive value [PPV], negative predictive value [NPV], likelihood ratios [LR], area under receiver operating characteristic curve [AUROC]) of a 10-item brief geriatric assessment (BGA) for the prediction of prolonged length hospital stay (LHS) in older patients hospitalized in acute care wards after an emergency department (ED) visit, using artificial neural networks (ANNs); and to describe the contribution of each BGA item to the predictive accuracy using the AUROC value. A total of 993 geriatric ED users admitted to acute care wards were included in this prospective cohort study. Age >85years, gender male, polypharmacy, non use of formal and/or informal home-help services, history of falls, temporal disorientation, place of living, reasons and nature for ED admission, and use of psychoactive drugs composed the 10 items of BGA and were recorded at the ED admission. The prolonged LHS was defined as the top third of LHS. The ANNs were conducted using two feeds forward (multilayer perceptron [MLP] and modified MLP). The best performance was reported with the modified MLP involving the 10 items (sensitivity=62.7%; specificity=96.6%; PPV=87.1; NPV=87.5; positive LR=18.2; AUC=90.5). In this model, presence of chronic conditions had the highest contributions (51.3%) in AUROC value. The 10-item BGA appears to accurately predict prolonged LHS, using the ANN MLP method, showing the best criteria performance ever reported until now. Presence of chronic conditions was the main contributor for the predictive accuracy. Copyright © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

KSC-2009-2537

NASA Image and Video Library

2009-04-06

CAPE CANAVERAL, Fla. – The sound suppression system is tested on the mobile launcher platform on Launch Pad 39B at NASA's Kennedy Space Center in Florida. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X flight test that is targeted for summer 2009. The mobile launcher platform was handed over to the Constellation Program and modified for the Ares I-X flight test. It is being tested before being moved to the Vehicle Assembly Building for assembly of the Ares I-X rocket. A sound suppression water system is in¬stalled on the pads to protect against damage by acoustical energy and rocket exhaust reflected from the flame trench and mobile launcher plat¬form during a launch. The sound suppression system includes an elevated 290-foot-high water tank with a capacity of 300,000 gallons. The water releases just prior to the ignition of the rocket and flows through 7-foot-diameter pipes for about 20 seconds. A torrent of water will flow onto the mobile launcher platform from six large quench nozzles, or “rainbirds,” mounted on its surface. The rainbirds are 12 feet high. The two in the center are 42 inches in diameter; the other four have a 30-inch diameter. Photo credit: NASA/Jim Grossmann

KSC-2009-2538

NASA Image and Video Library

2009-04-06

CAPE CANAVERAL, Fla. – The sound suppression system is tested on the mobile launcher platform on Launch Pad 39B at NASA's Kennedy Space Center in Florida. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X flight test that is targeted for summer 2009. The mobile launcher platform was handed over to the Constellation Program and modified for the Ares I-X flight test. It is being tested before being moved to the Vehicle Assembly Building for assembly of the Ares I-X rocket. A sound suppression water system is in¬stalled on the pads to protect against damage by acoustical energy and rocket exhaust reflected from the flame trench and mobile launcher plat¬form during a launch. The sound suppression system includes an elevated 290-foot-high water tank with a capacity of 300,000 gallons. The water releases just prior to the ignition of the rocket and flows through 7-foot-diameter pipes for about 20 seconds. A torrent of water will flow onto the mobile launcher platform from six large quench nozzles, or “rainbirds,” mounted on its surface. The rainbirds are 12 feet high. The two in the center are 42 inches in diameter; the other four have a 30-inch diameter. Photo credit: NASA/Jim Grossmann

Enhancing Mobility: Integrating New Services into Your Library's Mobile Platform to Increase Traffic

ERIC Educational Resources Information Center

Felts, John W., Jr.

2014-01-01

Kimbel Library launched its mobile environment and ran it in full production for several months yet usage patterns were quite low and flat. The library only saw a substantial increase in usage when new, value-added services were integrated into this platform. Upon implementing and integrating discovery services, chat and SMS capabilities, and…

KENNEDY SPACE CENTER, FLA. - Workers on the mobile service tower on Launch Pad 17-B, Cape Canaveral Air Force Station, watch as the Space Infrared Telescope Facility (SIRTF) clears the platform. SIRTF will be attached to the Delta II rocket and encapsulated in its fairing before launch. Consisting of three cryogenically cooled science instruments and an 0.85-meter telescope, SIRTF is one of NASA’s largest infrared telescopes to be launched. It is the fourth and final element in NASA’s family of orbiting “Great Observatories.” SIRTF will obtain images and spectra by detecting the infrared energy, or heat, radiated by objects in space. Most of this infrared radiation is blocked by the Earth's atmosphere and cannot be observed from the ground.

NASA Image and Video Library

2003-08-10

KENNEDY SPACE CENTER, FLA. - Workers on the mobile service tower on Launch Pad 17-B, Cape Canaveral Air Force Station, watch as the Space Infrared Telescope Facility (SIRTF) clears the platform. SIRTF will be attached to the Delta II rocket and encapsulated in its fairing before launch. Consisting of three cryogenically cooled science instruments and an 0.85-meter telescope, SIRTF is one of NASA’s largest infrared telescopes to be launched. It is the fourth and final element in NASA’s family of orbiting “Great Observatories.” SIRTF will obtain images and spectra by detecting the infrared energy, or heat, radiated by objects in space. Most of this infrared radiation is blocked by the Earth's atmosphere and cannot be observed from the ground.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. Large Tandemloc bars have been attached to the platform to keep it level during lifting and installation. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Space and Earth Observations from Stratospheric Balloons

NASA Astrophysics Data System (ADS)

Peterzen, Steven; Ubertini, Pietro; Masi, Silvia; Ibba, Roberto; Ivano, Musso; Cardillo, Andrea; Romeo, Giovanni; Dragøy, Petter; Spoto, Domenico

Stratospheric balloons are rapidly becoming the vehicle of choice for near space investigations and earth observations by a variety of science disciplines. With the ever increasing research into climatic change, instruments suspended from stratospheric balloons offer the science team a unique, stable and reusable platform that can circle the Earth in the polar region or equatorial zone for thirty days or more. The Italian Space Agency (ASI) in collaboration with Andoya Rocket Range (Andenes, Norway) has opened access in the far northern latitudes above 78o N from Longyearbyen, Svalbard. In 2006 the first Italian UltraLite Long Duration Balloon was launched from Baia Terra Nova, Mario Zuchelli station in Antarctica and now ASI is setting up for the their first equatorial stratospheric launch from their satellite receiving station and rocket launch site in Malindi, Kenya. For the equatorial missions we have analysed the statistical properties of trajectories considering the biennal oscillation and the seasonal effects of the stratospheric winds. Maintaining these launch sites offer the science community 3 point world coverage for heavy lift balloons as well as the rapidly deployed Ultralight payloads and TM system ASI developed to use for test platforms, micro experiments, as well as a comprehensive student pilot program

STS-112 M.S. Wolf suits up for launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-112 Mission Specialist David Wolf suits up for launch, just hours away. STS-112 is the 15th assembly flight to the International Space Station, carrying the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station. Launch is scheduled for 3:46 p.m. EDT from Launch Pad 39B. .

STS-112 M.S. Sellers suits up for launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - During suitup for launch, STS-112 Mission Specialist Piers Sellers smiles in anticipation of his first Shuttle flight. STS-112 is the 15th assembly flight to the International Space Station, carrying the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station. Launch is scheduled for 3:46 p.m. EDT from Launch Pad 39B.

KSC-2012-1676

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a large crane lifts a new engine and generator high overhead for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1349

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lift an Apollo era diesel engine away from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1674

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as a large crane lifts a new engine and generator for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1350

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lift an Apollo era diesel engine away from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1675

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a large crane is used to lift a new engine and generator high overhead for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1678

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as a large crane lowers a new engine and generator for installation inside crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1337

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane begins to lift part of an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1351

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Just outside of the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lift an Apollo era diesel engine away from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1336

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is lowered toward crawler-transporter 2 CT-2) so that the Apollo era diesel engine can be removed. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1346

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as a crane begins to lift an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1340

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane operator lifts part of an Apollo era diesel engine away from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1673

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as a large crane begins to lift a new engine and generator for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1338

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane begins to lift part of an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1352

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Just outside of the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lift an Apollo era diesel engine away from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1344

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. ––Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a technician monitors the progress as a crane begins to lift an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1677

NASA Image and Video Library

2012-03-08

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a large crane lifts a new engine and generator high overhead for installation on crawler-transporter 2 CT-2). The Apollo era diesel engines were removed last month. Work continues in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2012-1334

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. – Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is lowered toward crawler-transporter 2 CT-2) so that the Apollo era diesel engine can be removed. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1348

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a technician monitors the progress as a crane lifts an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1345

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians prepare an Apollo era diesel engine to be lifted by crane from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1339

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane lifts part of an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1347

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as a crane lifts an Apollo era diesel engine from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

Platform C South Arrival

NASA Image and Video Library

2016-08-05

The second section of the first half of the C-level work platforms, C South, for NASA’s Space Launch System (SLS) rocket was offloaded from a heavy transport truck in a staging area on the west side of the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Gas chimney detection based on improving the performance of combined multilayer perceptron and support vector classifier

NASA Astrophysics Data System (ADS)

Hashemi, H.; Tax, D. M. J.; Duin, R. P. W.; Javaherian, A.; de Groot, P.

2008-11-01

Seismic object detection is a relatively new field in which 3-D bodies are visualized and spatial relationships between objects of different origins are studied in order to extract geologic information. In this paper, we propose a method for finding an optimal classifier with the help of a statistical feature ranking technique and combining different classifiers. The method, which has general applicability, is demonstrated here on a gas chimney detection problem. First, we evaluate a set of input seismic attributes extracted at locations labeled by a human expert using regularized discriminant analysis (RDA). In order to find the RDA score for each seismic attribute, forward and backward search strategies are used. Subsequently, two non-linear classifiers: multilayer perceptron (MLP) and support vector classifier (SVC) are run on the ranked seismic attributes. Finally, to capitalize on the intrinsic differences between both classifiers, the MLP and SVC results are combined using logical rules of maximum, minimum and mean. The proposed method optimizes the ranked feature space size and yields the lowest classification error in the final combined result. We will show that the logical minimum reveals gas chimneys that exhibit both the softness of MLP and the resolution of SVC classifiers.

The effect of imposing 'fractional abundance constraints' onto the multilayer perceptron for sub-pixel land cover classification

NASA Astrophysics Data System (ADS)

Heremans, Stien; Suykens, Johan A. K.; Van Orshoven, Jos

2016-02-01

To be physically interpretable, sub-pixel land cover fractions or abundances should fulfill two constraints, the Abundance Non-negativity Constraint (ANC) and the Abundance Sum-to-one Constraint (ASC). This paper focuses on the effect of imposing these constraints onto the MultiLayer Perceptron (MLP) for a multi-class sub-pixel land cover classification of a time series of low resolution MODIS-images covering the northern part of Belgium. Two constraining modes were compared, (i) an in-training approach that uses 'softmax' as the transfer function in the MLP's output layer and (ii) a post-training approach that linearly rescales the outputs of the unconstrained MLP. Our results demonstrate that the pixel-level prediction accuracy is markedly increased by the explicit enforcement, both in-training and post-training, of the ANC and the ASC. For aggregations of pixels (municipalities), the constrained perceptrons perform at least as well as their unconstrained counterparts. Although the difference in performance between the in-training and post-training approach is small, we recommend the former for integrating the fractional abundance constraints into MLPs meant for sub-pixel land cover estimation, regardless of the targeted level of spatial aggregation.

Mirror Langmuir probe: a technique for real-time measurement of magnetized plasma conditions using a single Langmuir electrode.

PubMed

LaBombard, B; Lyons, L

2007-07-01

A new method for the real-time evaluation of the conditions in a magnetized plasma is described. The technique employs an electronic "mirror Langmuir probe" (MLP), constructed from bipolar rf transistors and associated high-bandwidth electronics. Utilizing a three-state bias wave form and active feedback control, the mirror probe's I-V characteristic is continuously adjusted to be a scaled replica of the "actual" Langmuir electrode immersed in a plasma. Real-time high-bandwidth measurements of the plasma's electron temperature, ion saturation current, and floating potential can thereby be obtained using only a single electrode. Initial tests of a prototype MLP system are reported, proving the concept. Fast-switching metal-oxide-semiconductor field-effect transistors produce the required three-state voltage bias wave form, completing a full cycle in under 1 mus. Real-time outputs of electron temperature, ion saturation current, and floating potential are demonstrated, which accurately track an independent computation of these values from digitally stored I-V characteristics. The MLP technique represents a significant improvement over existing real-time methods, eliminating the need for multiple electrodes and sampling all three plasma parameters at a single spatial location.

Effects of five oleanolic acid triterpenoid saponins from the rhizome of Anemone raddeana on stimulus-induced superoxide generation, phosphorylation of proteins and translocation of cytosolic compounds to cell membrane in human neutrophils.

PubMed

Wei, Shihu; He, Wenfei; Lu, Jincai; Wang, Zhonghuan; Yamashita, Koichi; Yokoyama, Masanori; Kodama, Hiroyuki

2012-03-01

Five oleanolic acid triterpenoid saponins (OTS-1, 2, 3, 4 and 5) were isolated from the rhizome of Anemone raddeana. The effect of these triterpenoid saponins on stimulus-induced superoxide generation in human neutrophils was assayed by measuring the reduction of ferricytochrome c using a dual-beam spectrophotometer. The phosphorylation of neutrophil proteins, and translocation of p67(phox), p47(phox) and Rac to plasma membrane were investigated using specific monoclonal antibodies. The five oleanolic acid triterpenoid saponins used in this experiment suppressed N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation in a concentration-dependent manner. OTS-1, 2 and 4 suppressed phorbol 12-myristate 13-acetate (PMA)- and arachidonic acid (AA)-induced superoxide generation in a concentration-dependent manner, but OTS-3 and 5 showed no effect. fMLP- and PMA-induced tyrosyl or serine/threonine phosphorylation, and fMLP-, PMA- and AA-induced translocation of p67(phox), p47(phox) and Rac to plasma membrane were in parallel with the suppression of the stimulus-induced superoxide generation. Copyright © 2011 Elsevier B.V. All rights reserved.

Fenspiride and membrane transduction signals in rat alveolar macrophages.

PubMed

Féray, J C; Mohammadi, K; Taouil, K; Brunet, J; Garay, R P; Hannaert, P

1997-07-15

Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophages, high fenspiride concentrations (1 mM) were required to inhibit the calcium signals evoked by the calcium agonist Bay K8644 or by ionomycin. Moreover, fenspiride (1 mM) was a poor inhibitor of the cell membrane depolarization induced by gramicidine D. By contrast, fenspiride blocked Na+-H+ antiport activation by (i) fMLP with an IC50 = 3.1 +/- 1.9 nM and (ii) PMA (phorbol 12-myristate 13-acetate) with an IC50 = 9.2 +/- 3.1 nM. Finally, protein kinase C (PKC) activity of macrophage homogenate was not significantly modified by 10 or 100 microM fenspiride (at 100 microM: 2.57 +/- 1.60 vs. 2.80 +/- 1.71 pmol/10(6) cells/min). In conclusion, fenspiride inhibits fMLP- and PMA-induced pH signals in rat alveolar macrophages, probably by acting distally on the PKC transduction signal. This pH antagonistic action may be relevant for the antiinflammatory mechanism of fenspiride and requires further investigation.

T-wave end detection using neural networks and Support Vector Machines.

PubMed

Suárez-León, Alexander Alexeis; Varon, Carolina; Willems, Rik; Van Huffel, Sabine; Vázquez-Seisdedos, Carlos Román

2018-05-01

In this paper we propose a new approach for detecting the end of the T-wave in the electrocardiogram (ECG) using Neural Networks and Support Vector Machines. Both, Multilayer Perceptron (MLP) neural networks and Fixed-Size Least-Squares Support Vector Machines (FS-LSSVM) were used as regression algorithms to determine the end of the T-wave. Different strategies for selecting the training set such as random selection, k-means, robust clustering and maximum quadratic (Rényi) entropy were evaluated. Individual parameters were tuned for each method during training and the results are given for the evaluation set. A comparison between MLP and FS-LSSVM approaches was performed. Finally, a fair comparison of the FS-LSSVM method with other state-of-the-art algorithms for detecting the end of the T-wave was included. The experimental results show that FS-LSSVM approaches are more suitable as regression algorithms than MLP neural networks. Despite the small training sets used, the FS-LSSVM methods outperformed the state-of-the-art techniques. FS-LSSVM can be successfully used as a T-wave end detection algorithm in ECG even with small training set sizes. Copyright © 2018 Elsevier Ltd. All rights reserved.

Essential role of protein kinase C zeta in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP.

PubMed

Kuribayashi, Kageaki; Nakamura, Kiminori; Tanaka, Maki; Sato, Tsutomu; Kato, Junji; Sasaki, Katsunori; Takimoto, Rishu; Kogawa, Katsuhisa; Terui, Takeshi; Takayama, Tetsuji; Onuma, Takayuki; Matsunaga, Takuya; Niitsu, Yoshiro

2007-03-26

Under various pathological conditions, including infection, malignancy, and autoimmune diseases, tissues are incessantly exposed to reactive oxygen species produced by infiltrating inflammatory cells. We show augmentation of motility associated with morphological changes of human squamous carcinoma SASH1 cells, human peripheral monocytes (hPMs), and murine macrophage-like cell line J774.1 by superoxide stimulation. We also disclose that motility of hPMs and J774.1 induced by a chemotactic peptide (N-formyl-methionyl-leucyl-phenylalanine [fMLP]) was inhibited by superoxide dismutase or N-acetylcystein, indicating stimulation of motility by superoxide generated by fMLP stimulation. In these cells, protein kinase C (PKC) zeta was activated to phosphorylate RhoGDI-1, which liberated RhoGTPases, leading to their activation. These events were inhibited by dominant-negative PKCzeta in SASH1 cells, myristoylated PKCzeta peptides in hPMs and J774.1, or a specific inhibitor of RhoGTPase in SASH1, hPMs, and J774.1. These results suggest a new approach for manipulation of inflammation as well as tumor cell invasion by targeting this novel signaling pathway.

Essential role of protein kinase C ζ in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP

PubMed Central

Kuribayashi, Kageaki; Nakamura, Kiminori; Tanaka, Maki; Sato, Tsutomu; Kato, Junji; Sasaki, Katsunori; Takimoto, Rishu; Kogawa, Katsuhisa; Terui, Takeshi; Takayama, Tetsuji; Onuma, Takayuki; Matsunaga, Takuya; Niitsu, Yoshiro

2007-01-01

Under various pathological conditions, including infection, malignancy, and autoimmune diseases, tissues are incessantly exposed to reactive oxygen species produced by infiltrating inflammatory cells. We show augmentation of motility associated with morphological changes of human squamous carcinoma SASH1 cells, human peripheral monocytes (hPMs), and murine macrophage-like cell line J774.1 by superoxide stimulation. We also disclose that motility of hPMs and J774.1 induced by a chemotactic peptide (N-formyl-methionyl-leucyl-phenylalanine [fMLP]) was inhibited by superoxide dismutase or N-acetylcystein, indicating stimulation of motility by superoxide generated by fMLP stimulation. In these cells, protein kinase C (PKC) ζ was activated to phosphorylate RhoGDI-1, which liberated RhoGTPases, leading to their activation. These events were inhibited by dominant-negative PKCζ in SASH1 cells, myristoylated PKCζ peptides in hPMs and J774.1, or a specific inhibitor of RhoGTPase in SASH1, hPMs, and J774.1. These results suggest a new approach for manipulation of inflammation as well as tumor cell invasion by targeting this novel signaling pathway. PMID:17389234

New insights into soil temperature time series modeling: linear or nonlinear?

NASA Astrophysics Data System (ADS)

Bonakdari, Hossein; Moeeni, Hamid; Ebtehaj, Isa; Zeynoddin, Mohammad; Mahoammadian, Abdolmajid; Gharabaghi, Bahram

2018-03-01

Soil temperature (ST) is an important dynamic parameter, whose prediction is a major research topic in various fields including agriculture because ST has a critical role in hydrological processes at the soil surface. In this study, a new linear methodology is proposed based on stochastic methods for modeling daily soil temperature (DST). With this approach, the ST series components are determined to carry out modeling and spectral analysis. The results of this process are compared with two linear methods based on seasonal standardization and seasonal differencing in terms of four DST series. The series used in this study were measured at two stations, Champaign and Springfield, at depths of 10 and 20 cm. The results indicate that in all ST series reviewed, the periodic term is the most robust among all components. According to a comparison of the three methods applied to analyze the various series components, it appears that spectral analysis combined with stochastic methods outperformed the seasonal standardization and seasonal differencing methods. In addition to comparing the proposed methodology with linear methods, the ST modeling results were compared with the two nonlinear methods in two forms: considering hydrological variables (HV) as input variables and DST modeling as a time series. In a previous study at the mentioned sites, Kim and Singh Theor Appl Climatol 118:465-479, (2014) applied the popular Multilayer Perceptron (MLP) neural network and Adaptive Neuro-Fuzzy Inference System (ANFIS) nonlinear methods and considered HV as input variables. The comparison results signify that the relative error projected in estimating DST by the proposed methodology was about 6%, while this value with MLP and ANFIS was over 15%. Moreover, MLP and ANFIS models were employed for DST time series modeling. Due to these models' relatively inferior performance to the proposed methodology, two hybrid models were implemented: the weights and membership function of MLP and ANFIS (respectively) were optimized with the particle swarm optimization (PSO) algorithm in conjunction with the wavelet transform and nonlinear methods (Wavelet-MLP & Wavelet-ANFIS). A comparison of the proposed methodology with individual and hybrid nonlinear models in predicting DST time series indicates the lowest Akaike Information Criterion (AIC) index value, which considers model simplicity and accuracy simultaneously at different depths and stations. The methodology presented in this study can thus serve as an excellent alternative to complex nonlinear methods that are normally employed to examine DST.

U.S. Space Station platform - Configuration technology for customer servicing

NASA Technical Reports Server (NTRS)

Dezio, Joseph A.; Walton, Barbara A.

1987-01-01

Features of the Space Station coorbiting and polar orbiting platforms (COP and POP, respectively) are described that will allow them to be configured optimally to meet mission requirements and to be assembled, serviced, and modified on-orbit. Both of these platforms were designed to permit servicing at the Shuttle using the remote manipulator system with teleoperated end effectors; EVA was planned as a backup and for unplanned payload failure modes. Station-based servicing is discussed as well as expendable launch vehicle-based servicing concepts.

Platform B North Installation

NASA Image and Video Library

2016-12-16

Construction workers wearing safety harnesses and tethered lines assist with the installation of the second half of the B-level work platforms, B north, for NASA’s Space Launch System (SLS) rocket, high up in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. They are securing the large bolts that hold the platform securely in place on the north side of High Bay 3. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform B North Installation

NASA Image and Video Library

2016-12-16

A construction worker solders a section of steel during the installation of the second half of the B-level work platforms, B north, for NASA's Space Launch System (SLS) rocket, in High Bay 3 in the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Construction workers will secure the large bolts that hold the platform in place on the north wall. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

KSC-08pd3502

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is positioned for movement into NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-08pd3501

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from the transporter at NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-08pd3500

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft arrives at NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-08pd3499

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from a C-5 aircraft after arrival at Vandenberg Air Force Base Airfield in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-08pd3503

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – Workers move the NOAA-N Prime spacecraft into NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-08pd3498

NASA Image and Video Library

2008-11-04

VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from a C-5 aircraft after arrival at Vandenberg Air Force Base Airfield in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

KSC-2009-5913

NASA Image and Video Library

2009-10-27

CAPE CANAVERAL, Fla. – At Launch Pad 39B at NASA's Kennedy Space Center in Florida, the rotating service structure has been rolled back from the Constellation Program's 327-foot-tall Ares I-X rocket, sitting atop its mobile launcher platform, during preparations for launch. The transfer of the pad from the Space Shuttle Program to the Constellation Program took place May 31. Modifications made to the pad include the removal of shuttle unique subsystems, such as the orbiter access arm and a section of the gaseous oxygen vent arm, and the installation of three 600-foot lightning towers, access platforms, environmental control systems and a vehicle stabilization system. The data returned from more than 700 sensors throughout the rocket will be used to refine the design of future launch vehicles and bring NASA one step closer to reaching its exploration goals. The Ares I-X flight test is targeted for Oct. 27. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Kim Shiflett

KSC-2013-4208

NASA Image and Video Library

2013-12-03

CAPE CANAVERAL, Fla. -- A truck sprays water along the crawlerway to reduce dust ahead of crawler-transporter 1 as it continues its trek to Launch Pad 39A at NASA’s Kennedy Space Center in Florida. New jacking, equalizing and leveling, or JEL, hydraulic cylinders were installed on CT-1 and will be tested for increased load carrying capacity and reliability. The Ground Systems Development and Operations Program at Kennedy continues to upgrade the crawler-transporter as part of its general maintenance. CT-1 could be available to carry a variety of launch vehicles to the launch pad. Two crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Jim Grossmann

KSC-2013-4202

NASA Image and Video Library

2013-12-02

CAPE CANAVERAL, Fla. -- A truck sprays water along the crawlerway to reduce dust ahead of crawler-transporter 1 as it begins its trek to Launch Pad 39A at NASA’s Kennedy Space Center in Florida. New jacking, equalizing and leveling, or JEL, hydraulic cylinders were installed on CT-1 and are being tested for increased load carrying capacity and reliability. The Ground Systems Development and Operations Program at Kennedy continues to upgrade the crawler-transporter as part of its general maintenance. CT-1 could be available to carry a variety of launch vehicles to the launch pad. Two crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Daniel Casper

KSC-06pd2004

NASA Image and Video Library

2006-08-29

KENNEDY SPACE CENTER, FLA. - Space Shuttle Atlantis rolls up the ramp to Launch Pad 39B atop the crawler-transporter. The crawler has a leveling system designed to keep the top of the space shuttle vertical while negotiating the 5-percent grade leading to the top of the launch pad. Also, a laser docking system provides almost pinpoint accuracy when the crawler and mobile launcher platform are positioned at the launch pad. At right are the open rotating service structure and the fixed service structure topped by the 80-foot lightning mast. The shuttle had been moved off the launch pad due to concerns about the impact of Tropical Storm Ernesto, expected within 24 hours. The forecast of lesser winds expected from Ernesto and its projected direction convinced Launch Integration Manager LeRoy Cain and Shuttle Launch Director Mike Leinbach to return the shuttle to the launch pad. Photo credit: NASA/Kim Shiflett

KSC-06pd2003

NASA Image and Video Library

2006-08-29

KENNEDY SPACE CENTER, FLA. - A late-day sun spotlights Space Shuttle Atlantis as it rolls up the ramp to Launch Pad 39B atop the crawler-transporter. The crawler has a leveling system designed to keep the top of the space shuttle vertical while negotiating the 5-percent grade leading to the top of the launch pad. Also, a laser docking system provides almost pinpoint accuracy when the crawler and mobile launcher platform are positioned at the launch pad. At left are the open rotating service structure and the fixed service structure topped by the 80-foot lightning mast. The shuttle had been moved off the launch pad due to concerns about the impact of Tropical Storm Ernesto, expected within 24 hours. The forecast of lesser winds expected from Ernesto and its projected direction convinced Launch Integration Manager LeRoy Cain and Shuttle Launch Director Mike Leinbach to return the shuttle to the launch pad. Photo credit: NASA/Kim Shiflett

KSC-06pd2002

NASA Image and Video Library

2006-08-29

KENNEDY SPACE CENTER, FLA. - A late-day sun spotlights Space Shuttle Atlantis as it rolls up the ramp to Launch Pad 39B atop the crawler-transporter. The crawler has a leveling system designed to keep the top of the space shuttle vertical while negotiating the 5-percent grade leading to the top of the launch pad. Also, a laser docking system provides almost pinpoint accuracy when the crawler and mobile launcher platform are positioned at the launch pad. At left are the open rotating service structure and the fixed service structure topped by the 80-foot lightning mast. The shuttle had been moved off the launch pad due to concerns about the impact of Tropical Storm Ernesto, expected within 24 hours. The forecast of lesser winds expected from Ernesto and its projected direction convinced Launch Integration Manager LeRoy Cain and Shuttle Launch Director Mike Leinbach to return the shuttle to the launch pad. Photo credit: NASA/Kim Shiflett

Platform C South Arrival

NASA Image and Video Library

2016-08-05

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying the second section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform will be offloaded in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C south, for the agency’s Space Launch System (SLS) rocket. The platform will be delivered to the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Long Duration Balloon flights development. (Italian Space Agency)

NASA Astrophysics Data System (ADS)

Peterzen, S.; Masi, S.; Dragoy, P.; Ibba, R.; Spoto, D.

Stratospheric balloons are rapidly becoming the vehicle of choice for near space investigations and earth observations by a variety of science disciplines. With the ever increasing research into climatic change, earth observations, near space research and commercial component testing, instruments suspended from stratospheric balloons offer the science team a unique, stable and reusable platform that can circle the Earth in the polar region or equatorial zone for thirty days or more. The Italian Space Agency (ASI) in collaboration with Andoya Rocket Range (Andenes, Norway) has opened access in the far northern latitudes above 78º N from Longyearbyen, Svalbard. In 2006 the first Italian UltraLite Long Duration Balloon was launched from Baia Terra Nova, Mario Zuchelli station in Antarctica and now ASI is setting up for the their first equatorial stratospheric launch from their satellite receiving station and rocket launch site in Malindi, Kenya. For the equatorial missions we have analysed the statistical properties of trajectories considering the biennial oscillation and the seasonal effects of the stratospheric winds. Maintaining these launch sites offer the science community 3 point world coverage for heavy lift balloons as well as the rapidly deployed Ultra-light payloads and TM systems ASI developed to use for test platforms, micro experiments, as well as a comprehensive student pilot program. This paper discusses the development of the launch facilities and international LDB development.

A study to identify and compare airborne systems for in-situ measurements of launch vehicle effluents

NASA Technical Reports Server (NTRS)

Thomas, T. J.; Chace, A. S.

1974-01-01

An in-situ system for monitoring the concentration of HCl, CO, CO2, and Al2O3 in the cloud of reaction products that form as a result of a launch of solid propellant launch vehicle is studied. A wide array of instrumentation and platforms are reviewed to yield the recommended system. An airborne system suited to monitoring pollution concentrations over urban areas for the purpose of calibrating remote sensors is then selected using a similar methodology to yield the optimal configuration.

STS-113 workers search for oxygen leak

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- In the Payload Changeout Room, Launch Pad 39A, workers raise a platform toward the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

STS-113 workers search for oxygen leak

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Workers in the Payload Changeout Room, Launch Pad 39A, ride a platform toward the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

STS-113 workers search for oxygen leak

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Workers in the Payload Changeout Room, Launch Pad 39A, are on a platform in the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

KSC-02pd1709

NASA Image and Video Library

2002-11-12

KENNEDY SPACE CENTER, FLA. -- In the Payload Changeout Room, Launch Pad 39A, workers raise a platform toward the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

KSC-02pd1712

NASA Image and Video Library

2002-11-12

KENNEDY SPACE CENTER, FLA. -- Workers in the Payload Changeout Room, Launch Pad 39A, are on a platform in the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

KSC-02pd1710

NASA Image and Video Library

2002-11-12

KENNEDY SPACE CENTER, FLA. -- Workers in the Payload Changeout Room, Launch Pad 39A, ride a platform toward the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

KSC-02pd1711

NASA Image and Video Library

2002-11-12

KENNEDY SPACE CENTER, FLA. -- Workers in the Payload Changeout Room, Launch Pad 39A, are on a platform in the forward cargo bay area of Space Shuttle Endeavour to search for an oxygen leak. The launch of Endeavour on mission STS-113 was postponed Nov. 10, following the completion of tanking operations, due to higher than allowable oxygen levels in the orbiter's midbody. Workers will investigate the exact location and possible cause of the leak, and effect repairs. Launch has been tentatively set for no earlier than Nov. 18, between 7 and 11 p.m. EST.

KSC-08pd2109

NASA Image and Video Library

2008-07-23

CAPE CANAVERAL, Fla. – This elevated view shows workers on a platform welding a steel grid structure to the wall of the flame trench on Launch Pad 39A at NASA's Kennedy Space Center. Damage to the trench occurred during the launch of Discovery on the STS-124 mission. A 75- by 20-foot section of the east wall was destroyed and debris scattered as far as the pad perimeter fence. Repairs are expected to be completed before the targeted Oct. 8 launch of Atlantis on the NASA Hubble Space Telescope servicing mission. Photo credit: NASA/Jack Pfaller

Progress at Standard Space Platforms Corporation

NASA Astrophysics Data System (ADS)

Perkins, Frederick W.

1992-08-01

An account is given of a simple program structure with low costs and short schedules for the space R&D community operating outside mission-oriented, government-funded programs. In addition to furnishing launch services into orbit, the program structure furnishes engineering services through its ground station, control room, and 3-year duration 'MMSB' platform. Flights may begin as little as a year after contract signature.

Passive millimetre wave imaging for ballistic missile launch detection

NASA Astrophysics Data System (ADS)

Higgins, Christopher J.; Salmon, Neil A.

2008-10-01

QinetiQ has used a suite of modelling tools to predict the millimetric plume signatures from a range of ballistic missile types, based on the accepted theory that Bremsstrahlung emission, generated by the collision of free electrons with neutral species in a rocket motor plume, is the dominant signature mechanism. Plume signatures in terms of radiation temperatures varied from a few hundred Kelvin to over one thousand Kelvin, and were predicted to be dependent on emission frequency, propellant type and missile thrust. Two types of platform were considered for the passive mmw imager launch detection system; a High Altitude Platform Station (HAPS) and a satellite based platform in low, mid and geosynchronous earth orbits. It was concluded that the optimum operating frequency for a HAPS based imager would be 35GHz with a 4.5m aperture and a sensitivity of 20mK providing visibility through 500 vertical feet of cloud. For a satellite based platform with a nadir view, the optimum frequency is 220 GHz. With such a system, in a low earth orbit at an altitude of 320km, with a sensitivity of 20mK, a 29cm aperture would be desirable.

37. GENERAL VIEW OF SLC3W MST STATION 85.5 FROM NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. GENERAL VIEW OF SLC-3W MST STATION 85.5 FROM NORTHEAST CORNER SHOWING PLATFORM CONTROLS IN SOUTHWEST CORNER, COMMUNICATION STATION AND ELEVATOR ON WEST SIDE. STRETCH SLING CYLINDER PRESSURE GAUGE IN SOUTHWEST CORNER OF STATION 78 VISIBLE THROUGH CENTRAL OPENING. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

36. GENERAL VIEW OF SLC3W MST STATION 85.5 FROM SOUTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. GENERAL VIEW OF SLC-3W MST STATION 85.5 FROM SOUTHEAST CORNER SHOWING REMOVABLE SAFETY RAILS AROUND CENTRAL OPENING, STRETCH SLING CYLINDER, AND PULLEY ON WEST SIDE, AIR-CONDITIONING DUCTING IN NORTHWEST CORNER, PLATFORM SEGMENTS AND HINGES - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

VAB Platform K(2) Lift & Install into Highbay 3

NASA Image and Video Library

2016-03-07

A 250-ton crane is used to lower the second half of the K-level work platforms for NASA’s Space Launch System (SLS) rocket into High Bay 3 inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The platform will be secured about 86 feet above the VAB floor, on tower E of the high bay. The K work platforms will provide access to the SLS core stage and solid rocket boosters during processing and stacking operations on the mobile launcher. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft.

KSC-2015-1295

NASA Image and Video Library

2015-02-04

CAPE CANAVERAL, Fla. – The first stage of the United Launch Alliance Atlas V rocket for NASA's Magnetospheric Multiscale mission, or MMS, is in position on the launch platform in the mobile service tower at Space Launch Complex 41 on Cape Canaveral Air Force Station in Florida. MMS will study the mystery of how magnetic fields around Earth connect and disconnect, explosively releasing energy via a process known a magnetic reconnection. MMS consists of four identical spacecraft that work together to provide the first three-dimensional view of this fundamental process, which occurs throughout the universe. Launch is set for March 12. To learn more about MMS, visit http://www.nasa.gov/mms. Photo credit: NASA/Jim Grossmann

KSC-2015-1294

NASA Image and Video Library

2015-02-04

CAPE CANAVERAL, Fla. – The first stage of the United Launch Alliance Atlas V rocket for NASA's Magnetospheric Multiscale mission, or MMS, is positioned on the launch platform in the mobile service tower at Space Launch Complex 41 on Cape Canaveral Air Force Station in Florida. MMS will study the mystery of how magnetic fields around Earth connect and disconnect, explosively releasing energy via a process known a magnetic reconnection. MMS consists of four identical spacecraft that work together to provide the first three-dimensional view of this fundamental process, which occurs throughout the universe. Launch is set for March 12. To learn more about MMS, visit http://www.nasa.gov/mms. Photo credit: NASA/Jim Grossmann

The Adaptable, Deployable Entry and Placement Technology (ADEPT)

NASA Technical Reports Server (NTRS)

Wercinski, Paul

2017-01-01

The initial system-level development of the nano-ADEPT architecture will culminate in the launch of a 0.7 meter deployed diameter ADEPT sounding rocket flight experiment named, SR-1. Launch is planned for August 2017. The test will utilize the NASA Flight Opportunities Program sounding rocket platform provided by UP Aerospace to launch SR-1 to an apogee over 100 km and achieve re-entry conditions with a peak velocity near Mach 3. The SR-1 flight experiment will demonstrate most of the primary end-to-end mission stages including: launch in a stowed configuration, separation and deployment in exo-atmospheric conditions, and passive ballistic re-entry of a 70-degree half-angle faceted cone geometry.

KSC-2012-1356

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Just outside of the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, an Apollo era diesel engine is secured onto the flatbed of a truck after it was removed from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1341

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. ––– Outside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lower part of an Apollo era diesel engine from crawler-transporter 2 CT-2) onto the flatbed of a truck. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1342

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Outside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a crane is used to lower part of an Apollo era diesel engine from crawler-transporter 2 CT-2) onto the flatbed of a truck. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1335

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a worker helps guide a crane as it is lowered toward crawler-transporter 2 CT-2) so that the Apollo era diesel engine can be removed. New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-2012-1355

NASA Image and Video Library

2012-02-15

CAPE CANAVERAL, Fla. –– Just outside of the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, technicians help secure an Apollo era diesel engine onto the flatbed of a truck after it was removed from crawler-transporter 2 CT-2). New engines will be installed later this month. Work is in progress in high bay 2 to upgrade CT-2 so that it can carry NASA’s Space Launch System heavy-lift rocket, which is under design, and new Orion spacecraft to the launch pad. The crawler-transporters were used to carry the mobile launcher platform and space shuttle to Launch Complex 39 for space shuttle launches for 30 years. Photo credit: NASA/Kim Shiflett

KSC-08pd1109

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center, dawn reveals the arrival of space shuttle Discovery, secured atop the mobile launch platform below, at Launch Pad 39A to begin prelaunch processing for the STS-124 mission. The 3.4-mile journey from the Vehicle Assembly Building began at 11:47 p.m. on May 2. The shuttle arrived at the launch pad at 4:25 a.m. EDT May 3 and was secured, or hard down, by 6:06 a.m. On the 13-day mission, Discovery and its crew will deliver the Japan Aerospace Exploration Agency's Japanese Experiment Module – Pressurized Module and the Japanese Remote Manipulator System. Launch is targeted for May 31. Photo credit: NASA/Troy Cryder

KSC-08pd1106

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center, space shuttle Discovery, secured atop the mobile launch platform below, arrives at Launch Pad 39A to begin prelaunch processing for the STS-124 mission. The 3.4-mile journey from the Vehicle Assembly Building began at 11:47 p.m. on May 2. The shuttle arrived at the launch pad at 4:25 a.m. EDT May 3 and was secured, or hard down, by 6:06 a.m. On the 13-day mission, Discovery and its crew will deliver the Japan Aerospace Exploration Agency's Japanese Experiment Module – Pressurized Module and the Japanese Remote Manipulator System. Launch is targeted for May 31. Photo credit: NASA/Troy Cryder

KSC-08pd1105

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- This aerial view of NASA's Kennedy Space Center shows space shuttle Discovery, secured atop a mobile launch platform as it is moved into position at Launch Pad 39A to prepare for the STS-124 mission. The 3.4-mile journey from the Vehicle Assembly Building began at 11:47 p.m. on May 2. The shuttle arrived at the launch pad at 4:25 a.m. EDT May 3 and was secured, or hard down, by 6:06 a.m. On the 13-day mission, Discovery and its crew will deliver the Japan Aerospace Exploration Agency's Japanese Experiment Module – Pressurized Module and the Japanese Remote Manipulator System. Launch is targeted for May 31. Photo credit: NASA/Troy Cryder

KSC-08pd1110

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center, the sun rises upon the arrival of space shuttle Discovery, secured atop the mobile launch platform below, at Launch Pad 39A to begin prelaunch processing for the STS-124 mission. The 3.4-mile journey from the Vehicle Assembly Building began at 11:47 p.m. on May 2. The shuttle arrived at the launch pad at 4:25 a.m. EDT May 3 and was secured, or hard down, by 6:06 a.m. On the 13-day mission, Discovery and its crew will deliver the Japan Aerospace Exploration Agency's Japanese Experiment Module – Pressurized Module and the Japanese Remote Manipulator System. Launch is targeted for May 31. Photo credit: NASA/Troy Cryder

Saturn V Vehicle for the Apollo 4 Mission in the Vehicle Assembly Building

NASA Technical Reports Server (NTRS)

1967-01-01

This photograph depicts the Saturn V vehicle (SA-501) for the Apollo 4 mission in the Vehicle Assembly Building (VAB) at the Kennedy Space Center (KSC). After the completion of the assembly operation, the work platform was retracted and the vehicle was readied to rollout from the VAB to the launch pad. The Apollo 4 mission was the first launch of the Saturn V launch vehicle. Objectives of the unmanned Apollo 4 test flight were to obtain flight information on launch vehicle and spacecraft structural integrity and compatibility, flight loads, stage separation, and subsystems operation including testing of restart of the S-IVB stage, and to evaluate the Apollo command module heat shield. The Apollo 4 was launched on November 9, 1967 from KSC.

Geostationary platform systems concepts definition study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1980-01-01

The results of a geostationary platform concept analysis are summarized. Mission and payloads definition, concept selection, the requirements of an experimental platform, supporting research and technology, and the Space Transportation System interface requirements are addressed. It is concluded that platforms represent a logical extension of current trends toward larger, more complex, multifrequency satellites. Geostationary platforms offer significant cost savings compared to individual satellites, with the majority of these economies being realized with single Shuttle launched platforms. Further cost savings can be realized, however, by having larger platforms. Platforms accommodating communications equipment that operates at multiple frequencies and which provide larger scale frequency reuse through the use of large aperture multibeam antennas and onboard switching maximize the useful capacity of the orbital arc and frequency spectrum. Projections of market demand indicate that such conservation measures are clearly essential if orderly growth is to be provided for. In addition, it is pointed out that a NASA experimental platform is required to demonstrate the technologies necessary for operational geostationary platforms of the 1990's.

From NHS Choices to the integrated customer service platform.

PubMed

Gann, Bob; Grant, Maria J

2013-03-01

In 2013 the NHS Commissioning Board launches its new integrated customer service platform. The new service utilises the full range of channels (web, telephone, apps etc) to provide access to information to support transparency, participation and transactions. Digital health services have proven benefits in informed choice, shared decision making and patient participation. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. ISOMETRIC: EXISTING ML NO. 3 LAUNCHER. Sheet A1 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

STS-30 Atlantis, OV-104, on the mobile launcher platform heads to KSC LC pad

NASA Technical Reports Server (NTRS)

1989-01-01

STS-30 Atlantis, Orbiter Vehicle (OV) 104, riding atop the mobile launcher platform and the crawler transporter approaches Kennedy Space Center (KSC) Launch Complex (LC) pad 39B. This backlit view highlights OV-104's profile, the external tank (ET), and one of the two solid rocket boosters (SRBs) as it moves up LC pad 39B incline.

Dynamics of incremental motion devices associated with planetary exploration spacecraft. [Mariner Jupiter Saturn 1977

NASA Technical Reports Server (NTRS)

Hughes, R. O.

1975-01-01

Incremental motion devices provide accurate and rapid movement of spacecraft science platforms, antennas and related mechanisms. The paper considers the computerized simulation of a stepper motor/gear train/ science platform system that will be launched on the Mariner Jupiter Saturn 1977. It was determined that a smaller stepper motor could be used as the prime mover for the science platform, and it was concluded that the existing digital controller was unable to achieve the required pointing accuracy, and a new controller design was necessary.

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform is being lifted and transferred onto support stands in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Mobile Launch Platform Vehicle Assembly Area (SWMU 056) Biosparge Expansion Interim Measures Work Plan

NASA Technical Reports Server (NTRS)

Burcham, Michael S.; Daprato, Rebecca C.

2016-01-01

This document presents the design details for an Interim Measure (IM) Work Plan (IMWP) for the Mobile Launch Platform/Vehicle Assembly Building (MLPV) Area, located at the John F. Kennedy Space Center (KSC), Florida. The MLPV Area has been designated Solid Waste Management Unit Number 056 (SWMU 056) under KSC's Resource Conservation and Recovery Act (RCRA) Corrective Action Program. This report was prepared by Geosyntec Consultants (Geosyntec) for the National Aeronautics and Space Administration (NASA) under contract number NNK09CA02B and NNK12CA13B, project control number ENV1642. The Advanced Data Package (ADP) presentation covering the elements of this IMWP report received KSC Remediation Team (KSCRT) approval at the December 2015 Team Meeting; the meeting minutes are included in Appendix A.

RocketCam systems for providing situational awareness on rockets, spacecraft, and other remote platforms

NASA Astrophysics Data System (ADS)

Ridenoure, Rex

2004-09-01

Space-borne imaging systems derived from commercial technology have been successfully employed on launch vehicles for several years. Since 1997, over sixty such imagers - all in the product family called RocketCamTM - have operated successfully on 29 launches involving most U.S. launch systems. During this time, these inexpensive systems have demonstrated their utility in engineering analysis of liftoff and ascent events, booster performance, separation events and payload separation operations, and have also been employed to support and document related ground-based engineering tests. Such views from various vantage points provide not only visualization of key events but stunning and extremely positive public relations video content. Near-term applications include capturing key events on Earth-orbiting spacecraft and related proximity operations. This paper examines the history to date of RocketCams on expendable and manned launch vehicles, assesses their current utility on rockets, spacecraft and other aerospace vehicles (e.g., UAVs), and provides guidance for their use in selected defense and security applications. Broad use of RocketCams on defense and security projects will provide critical engineering data for developmental efforts, a large database of in-situ measurements onboard and around aerospace vehicles and platforms, compelling public relations content, and new diagnostic information for systems designers and failure-review panels alike.

New Air-Launched Small Missile (ALSM) Flight Testbed for Hypersonic Systems

NASA Technical Reports Server (NTRS)

Bui, Trong T.; Lux, David P.; Stenger, Michael T.; Munson, Michael J.; Teate, George F.

2007-01-01

The Phoenix Air-Launched Small Missile (ALSM) flight testbed was conceived and is proposed to help address the lack of quick-turnaround and cost-effective hypersonic flight research capabilities. The Phoenix ALSM testbed results from utilization of the United States Navy Phoenix AIM-54 (Hughes Aircraft Company, now Raytheon Company, Waltham, Massachusetts) long-range, guided air-to-air missile and the National Aeronautics and Space Administration (NASA) Dryden Flight Research Center (Edwards, California) F-15B (McDonnell Douglas, now the Boeing Company, Chicago, Illinois) testbed airplane. The retirement of the Phoenix AIM-54 missiles from fleet operation has presented an opportunity for converting this flight asset into a new flight testbed. This cost-effective new platform will fill the gap in the test and evaluation of hypersonic systems for flight Mach numbers ranging from 3 to 5. Preliminary studies indicate that the Phoenix missile is a highly capable platform; when launched from a high-performance airplane, the guided Phoenix missile can boost research payloads to low hypersonic Mach numbers, enabling flight research in the supersonic-to-hypersonic transitional flight envelope. Experience gained from developing and operating the Phoenix ALSM testbed will assist the development and operation of future higher-performance ALSM flight testbeds as well as responsive microsatellite-small-payload air-launched space boosters.

New Air-Launched Small Missile (ALSM) Flight Testbed for Hypersonic Systems

NASA Technical Reports Server (NTRS)

Bui, Trong T.; Lux, David P.; Stenger, Mike; Munson, Mike; Teate, George

2006-01-01

A new testbed for hypersonic flight research is proposed. Known as the Phoenix air-launched small missile (ALSM) flight testbed, it was conceived to help address the lack of quick-turnaround and cost-effective hypersonic flight research capabilities. The Phoenix ALSM testbed results from utilization of two unique and very capable flight assets: the United States Navy Phoenix AIM-54 long-range, guided air-to-air missile and the NASA Dryden F-15B testbed airplane. The U.S. Navy retirement of the Phoenix AIM-54 missiles from fleet operation has presented an excellent opportunity for converting this valuable flight asset into a new flight testbed. This cost-effective new platform will fill an existing gap in the test and evaluation of current and future hypersonic systems for flight Mach numbers ranging from 3 to 5. Preliminary studies indicate that the Phoenix missile is a highly capable platform. When launched from a high-performance airplane, the guided Phoenix missile can boost research payloads to low hypersonic Mach numbers, enabling flight research in the supersonic-to-hypersonic transitional flight envelope. Experience gained from developing and operating the Phoenix ALSM testbed will be valuable for the development and operation of future higher-performance ALSM flight testbeds as well as responsive microsatellite small-payload air-launched space boosters.