Nakagawa, So; Takahashi, Mahoko Ueda
2016-01-01
In mammals, approximately 10% of genome sequences correspond to endogenous viral elements (EVEs), which are derived from ancient viral infections of germ cells. Although most EVEs have been inactivated, some open reading frames (ORFs) of EVEs obtained functions in the hosts. However, EVE ORFs usually remain unannotated in the genomes, and no databases are available for EVE ORFs. To investigate the function and evolution of EVEs in mammalian genomes, we developed EVE ORF databases for 20 genomes of 19 mammalian species. A total of 736,771 non-overlapping EVE ORFs were identified and archived in a database named gEVE (http://geve.med.u-tokai.ac.jp). The gEVE database provides nucleotide and amino acid sequences, genomic loci and functional annotations of EVE ORFs for all 20 genomes. In analyzing RNA-seq data with the gEVE database, we successfully identified the expressed EVE genes, suggesting that the gEVE database facilitates studies of the genomic analyses of various mammalian species.Database URL: http://geve.med.u-tokai.ac.jp. © The Author(s) 2016. Published by Oxford University Press.
Nakagawa, So; Takahashi, Mahoko Ueda
2016-01-01
In mammals, approximately 10% of genome sequences correspond to endogenous viral elements (EVEs), which are derived from ancient viral infections of germ cells. Although most EVEs have been inactivated, some open reading frames (ORFs) of EVEs obtained functions in the hosts. However, EVE ORFs usually remain unannotated in the genomes, and no databases are available for EVE ORFs. To investigate the function and evolution of EVEs in mammalian genomes, we developed EVE ORF databases for 20 genomes of 19 mammalian species. A total of 736,771 non-overlapping EVE ORFs were identified and archived in a database named gEVE (http://geve.med.u-tokai.ac.jp). The gEVE database provides nucleotide and amino acid sequences, genomic loci and functional annotations of EVE ORFs for all 20 genomes. In analyzing RNA-seq data with the gEVE database, we successfully identified the expressed EVE genes, suggesting that the gEVE database facilitates studies of the genomic analyses of various mammalian species. Database URL: http://geve.med.u-tokai.ac.jp PMID:27242033
ACHP | News | Mrs. Laura Bush Presents "Preserve America History Teacher
. Laura Bush Presents "Preserve America History Teacher of the Year" Award to New Jersey Teacher Mrs. Laura Bush Presents "Preserve America History Teacher of the Year" Award to New Jersey Teacher October 14, 2005 Mrs. Laura Bush Presents "Preserve America History Teacher of the Year"
Electric vehicle station equipment for grid-integrated vehicles
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kempton, Willett; Kiamilev, Fouad; McGee, Rodney
Methods, systems, and apparatus transferring power between the grid and an electric vehicle are disclosed. The apparatus may include at least one vehicle communication port for interfacing with electric vehicle equipment (EVE) and a processor coupled to the at least one vehicle communication port to establish communication with the EVE, receive EVE attributes from the EVE, and transmit electric vehicle station equipment (EVSE) attributes to the EVE. Power may be transferred between the grid and the electric vehicle by maintaining EVSE attributes, establishing communication with the EVE, and transmitting the EVSE maintained attributes to the EVE.
Aggregation server for grid-integrated vehicles
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kempton, Willett
2015-05-26
Methods, systems, and apparatus for aggregating electric power flow between an electric grid and electric vehicles are disclosed. An apparatus for aggregating power flow may include a memory and a processor coupled to the memory to receive electric vehicle equipment (EVE) attributes from a plurality of EVEs, aggregate EVE attributes, predict total available capacity based on the EVE attributes, and dispatch at least a portion of the total available capacity to the grid. Power flow may be aggregated by receiving EVE operational parameters from each EVE, aggregating the received EVE operational parameters, predicting total available capacity based on the aggregatedmore » EVE operational parameters, and dispatching at least a portion of the total available capacity to the grid.« less
Tanaka, Motonari; Nanba, Daisuke; Mori, Seiji; Shiba, Fumio; Ishiguro, Hiroshi; Yoshino, Koichiro; Matsuura, Nariaki; Higashiyama, Shigeki
2004-10-01
A disintegrin and metalloproteases (ADAMs) are implicated in the ectodomain shedding of epidermal growth factor receptor (EGFR) ligands in EGFR transactivation. However, the activation mechanisms of ADAMs remain elusive. To analyze the regulatory mechanisms of ADAM activation, we performed yeast two-hybrid screening using the cytoplasmic domain of ADAM12 as bait, and identified a protein that we designated Eve-1. Two cDNAs were cloned and characterized. They encode alternatively spliced isoforms of Eve-1, called Eve-1a and Eve-1b, that have four and five tandem Src homology 3 (SH3) domains in the carboxyl-terminal region, respectively, and seven proline-rich SH3 domain binding motifs in the amino-terminal region. The short forms of Eve-1, Eve-1c and Eve-1d, translated at Met-371 are human counterparts of mouse Sh3d19. Northern blot analysis demonstrated that Eve-1 is abundantly expressed in skeletal muscle and heart. Western blot analysis revealed the dominant production of Eve-1c in human cancer cell lines. Knockdown of Eve-1 by small interfering RNA in HT1080 cells reduced the shedding of proHB-EGF induced by angiotensin II and 12-O-tetradecanoylphorbol-13-acetate, as well as the shedding of pro-transforming growth factor-alpha, promphiregulin, and proepiregulin by 12-O-tetradecanoylphorbol-13-acetate, suggesting that Eve-1 plays a role in positively regulating the activity of ADAMs in the signaling of EGFR-ligand shedding.
NASA Technical Reports Server (NTRS)
Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Chirstopher O.; Kleb, Bil
2010-01-01
This users manual provides in-depth information concerning installation and execution of LAURA, version 5. LAURA is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 LAURA code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintainability by eliminating the requirement for problem-dependent re-compilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multi-physics coupling. As a result, LAURA now shares gas-physics modules, MPI modules, and other low-level modules with the FUN3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU-standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.
NASA Technical Reports Server (NTRS)
Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, William L.
2013-01-01
This users manual provides in-depth information concerning installation and execution of LAURA, version 5. LAURA is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 LAURA code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintain ability by eliminating the requirement for problem dependent recompilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multi-physics coupling. As a result, LAURA now shares gas-physics modules, MPI modules, and other low-level modules with the Fun3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.
NASA Technical Reports Server (NTRS)
Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil
2011-01-01
This users manual provides in-depth information concerning installation and execution of Laura, version 5. Laura is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 Laura code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintainability by eliminating the requirement for problem dependent re-compilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multi-physics coupling. As a result, Laura now shares gas-physics modules, MPI modules, and other low-level modules with the Fun3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU-standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.
NASA Technical Reports Server (NTRS)
Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil
2009-01-01
This users manual provides in-depth information concerning installation and execution of LAURA, version 5. LAURA is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 LAURA code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintainability by eliminating the requirement for problem-dependent re-compilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multiphysics coupling. As a result, LAURA now shares gas-physics modules, MPI modules, and other low-level modules with the FUN3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU-standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.
NASA Technical Reports Server (NTRS)
Mazaheri, Alireza; Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil
2009-01-01
This users manual provides in-depth information concerning installation and execution of LAURA, version 5. LAURA is a structured, multi-block, computational aerothermodynamic simulation code. Version 5 represents a major refactoring of the original Fortran 77 LAURA code toward a modular structure afforded by Fortran 95. The refactoring improved usability and maintainability by eliminating the requirement for problem-dependent re-compilations, providing more intuitive distribution of functionality, and simplifying interfaces required for multiphysics coupling. As a result, LAURA now shares gas-physics modules, MPI modules, and other low-level modules with the FUN3D unstructured-grid code. In addition to internal refactoring, several new features and capabilities have been added, e.g., a GNU-standard installation process, parallel load balancing, automatic trajectory point sequencing, free-energy minimization, and coupled ablation and flowfield radiation.
Absolute branching fraction measurements of exclusive D+ semileptonic decays.
Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Chasse, M; Cravey, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Muramatsu, H; Park, C S; Park, W; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Weaver, K M; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Williams, J; Wiss, J; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Mahmood, A H; Severini, H; Asner, D M; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J
2005-10-28
Using data collected at the psi(3770) resonance with the CLEO-c detector at the Cornell e+e- storage ring, we present improved measurements of the absolute branching fractions of D+decays to K0e+ve, pi0e+ve, K*0e+ve, and p0e+ve, and the first observation and absolute branching fraction measurement of D+ --> omega e+ve. We also report the most precise tests to date of isospin invariance in semileptonic D0 and D+ decays.
78 FR 17653 - Wright, Laura H.; Notice of Filing
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-22
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-7103-000] Wright, Laura H.; Notice of Filing Take notice that on March 14, 2013, Laura H. Wright filed an application to hold interlocking positions, pursuant to section 305(b) of the Federal Power Act, 16 U.S.C. 825d(b) (2008) and Part...
Laura Pittman: The Nation's First Credentialed Direct Support Professional
ERIC Educational Resources Information Center
King, Tom
2007-01-01
This article profiles Laura Pittman, the nation's first credentialed Direct Support Professional (DSP). Laura is a DSP at the Orange Grove Center (OGC) in Chattanooga, Tennessee and has been working there for almost ten years. She has been a DSP for seven of those years, and in that role, supported four women at one of the Orange Grove Center…
STEVE -- a thinking person's screen editor
NASA Astrophysics Data System (ADS)
Fish, Adrian
STEve is an acronym for STarlink EVE and is an extended EDT-style EVE editor for use at Starlink nodes. The facility provides extra commands which are not part of standard EVE, and improves on one or two of the standard EVE commands. Help on all topics and keys is available from within the editor. The extensions and modifications present in STEve are particularly useful to Starlink users.
Cazzaniga, M E; Airoldi, M; Arcangeli, V; Artale, S; Atzori, F; Ballerio, A; Bianchi, G V; Blasi, L; Campidoglio, S; Ciccarese, M; Cursano, M C; Piezzo, M; Fabi, A; Ferrari, L; Ferzi, A; Ficorella, C; Frassoldati, A; Fumagalli, A; Garrone, O; Gebbia, V; Generali, D; La Verde, N; Maur, M; Michelotti, A; Moretti, G; Musolino, A; Palumbo, R; Pistelli, M; Porpiglia, M; Sartori, D; Scavelli, C; Schirone, A; Turletti, A; Valerio, M R; Vici, P; Zambelli, A; Clivio, L; Torri, V
2017-10-01
The BOLERO-2 trial reported efficacy and safety of Everolimus (EVE) and Exemestane (EXE) combination in HR+ advanced breast cancer (ABC) patients. The BALLET trial further evaluated the safety of EVE-EXE in HR+ ABC patients, without reporting efficacy data. Aim of the EVA real-life study was to collect data of efficacy and safety of EVE-EXE combination in the clinical setting, as well as exploring efficacy according to EVE Dose-Intensity (DI) and to previous treatment with Fulvestrant. This study aimed to describe the outcome of ABC pts treated with EVE-EXE combination in terms of median duration of EVE treatment and ORR in a real-life setting. From July 2013 to December 2015, the EVA study enrolled 404 pts. Median age was 61 years (33-83). Main metastatic sites were: bone (69.1%), soft tissue (34.7%) and viscera (33.2%). Median number of previous treatments was 2 (1-7). 43.3% of the pts had received Fulvestrant. Median exposure to EVE was 31.0 weeks (15.4-58.3) in the whole population. No difference was observed in terms of EVE exposure duration according to DI (p for trend = 0.27) or type of previous treatments (p = 0.33). ORR and Disease Control Rate (DCR) were observed in 31.6% and 60.7% of the patients, respectively, with the lowest ORRs confined in CHT pre-treated patients or in those who received the lowest DI of EVE. Grade 3-4 adverse events (AEs) were reported in 37.9% of the patients. Main AEs were: stomatitis (11.2%), non-infectious pneumonitis - NIP (3.8%), anaemia (3.8%) and fatigue (3.2%). The EVA study provided new insights in the use of EVE-EVE combination in HR+ ABC pts many years after the publication of the pivotal trial. The combination is safe and the best response could be obtained in patients receiving the full dose of EVE and/or after hormone-therapy as Fulvestrant in ABC. Copyright © 2017 Elsevier Ltd. All rights reserved.
Paleovirology of bornaviruses: What can be learned from molecular fossils of bornaviruses.
Horie, Masayuki; Tomonaga, Keizo
2018-04-06
Endogenous viral elements (EVEs) are virus-derived sequences embedded in eukaryotic genomes formed by germline integration of viral sequences. As many EVEs were integrated into eukaryotic genomes millions of years ago, EVEs are considered molecular fossils of viruses. EVEs can be valuable informational sources about ancient viruses, including their time scale, geographical distribution, genetic information, and hosts. Although integration of viral sequences is not required for replications of viruses other than retroviruses, many non-retroviral EVEs have been reported to exist in eukaryotes. Investigation of these EVEs has expanded our knowledge regarding virus-host interactions, as well as provided information on ancient viruses. Among them, EVEs derived from bornaviruses, non-retroviral RNA viruses, have been relatively well studied. Bornavirus-derived EVEs are widely distributed in animal genomes, including the human genome, and the history of bornaviruses can be dated back to more than 65 million years. Although there are several reports focusing on the biological significance of bornavirus-derived sequences in mammals, paleovirology of bornaviruses has not yet been well described and summarized. In this paper, we describe what can be learned about bornaviruses from endogenous bornavirus-like elements from the view of paleovirology using published results and our novel data. Copyright © 2018 Elsevier B.V. All rights reserved.
Infant welfare, philanthropy and entrepreneurship in Glasgow: Sister Laura's Infant Food Company.
Weaver, L T
2008-06-01
Laura Smith was sister-in-charge of the Children's Dispensary in Glasgow from 1897 to 1922. In 1911 she established Sister Laura's Infant Food Company to market a special milk formula of her own invention.The directors of the Dispensary were not amused. As the 'outdoor' department of the Royal Hospital for Sick Children (Yorkhill), the Dispensary was at the forefront of efforts to combat child ill health and malnutrition. This paper considers Laura Smith's initiative within the context of the health and care of infants of the time - high infant mortality, public and professional concerns for infant welfare, technological advances in food science, changing recommendations and practices of infant feeding and ambiguous relations between medicine and commerce.
The erudite humility of the historian: the 'critical epistemology' of Georges Lantéri-Laura.
Basso Lorini, Elisabetta
2017-06-01
This paper analyses the historical and epistemological work of the French psychiatrist Georges Lantéri-Laura (1930-2004) within the context of the French 'tradition' of history and philosophy of sciences, with special reference to Georges Canguilhem and Michel Foucault. After an introduction devoted to a critical survey of the most recent works on the history and historiography of psychiatry in French, the paper outlines Lantéri-Laura's approach by focusing especially on the role played by the methodological concept of 'semiology' as regards the relation between medicine and psychiatry. The last part of the paper draws attention to the relation between the history and philosophy of psychiatry in light of Lantéri-Laura's 'critical epistemology'.
Heckscher, Ellie S; Zarin, Aref Arzan; Faumont, Serge; Clark, Matthew Q; Manning, Laurina; Fushiki, Akira; Schneider-Mizell, Casey M; Fetter, Richard D; Truman, James W; Zwart, Maarten F; Landgraf, Matthias; Cardona, Albert; Lockery, Shawn R; Doe, Chris Q
2015-10-21
Bilaterally symmetric motor patterns--those in which left-right pairs of muscles contract synchronously and with equal amplitude (such as breathing, smiling, whisking, and locomotion)--are widespread throughout the animal kingdom. Yet, surprisingly little is known about the underlying neural circuits. We performed a thermogenetic screen to identify neurons required for bilaterally symmetric locomotion in Drosophila larvae and identified the evolutionarily conserved Even-skipped(+) interneurons (Eve/Evx). Activation or ablation of Eve(+) interneurons disrupted bilaterally symmetric muscle contraction amplitude, without affecting the timing of motor output. Eve(+) interneurons are not rhythmically active and thus function independently of the locomotor CPG. GCaMP6 calcium imaging of Eve(+) interneurons in freely moving larvae showed left-right asymmetric activation that correlated with larval behavior. TEM reconstruction of Eve(+) interneuron inputs and outputs showed that the Eve(+) interneurons are at the core of a sensorimotor circuit capable of detecting and modifying body wall muscle contraction. Copyright © 2015 Elsevier Inc. All rights reserved.
Heckscher, Ellie S.; Zarin, Aref Arzan; Faumont, Serge; Clark, Matthew Q.; Manning, Laurina; Fushiki, Akira; Schneider-Mizel, Casey M.; Fetter, Richard D.; Truman, James W.; Zwart, Maarten F.; Landgraf, Matthias; Cardona, Albert; Lockery, Shawn R.; Doe, Chris Q.
2015-01-01
Summary Bilaterally symmetric motor patterns—those in which left-right pairs of muscles contract synchronously and with equal amplitude (such as breathing, smiling, whisking, locomotion)—are widespread throughout the animal kingdom. Yet surprisingly little is known about the underlying neural circuits. We performed a thermogenetic screen to identify neurons required for bilaterally symmetric locomotion in Drosophila larvae, and identified the evolutionarily-conserved Even-skipped+ interneurons (Eve/Evx). Activation or ablation of Eve+ interneurons disrupted bilaterally symmetric muscle contraction amplitude, without affecting the timing of motor output. Eve+ interneurons are not rhythmically active, and thus function independently of the locomotor CPG. GCaMP6 calcium imaging of Eve+ interneurons in freely-moving larvae showed left-right asymmetric activation that correlated with larval behavior. TEM reconstruction of Eve+ interneuron inputs and outputs showed that the Eve+ interneurons are at the core of a sensorimotor circuit capable of detecting and modifying body wall muscle contraction. PMID:26439528
STEVE -- User Guide and Reference Manual
NASA Astrophysics Data System (ADS)
Fish, Adrian
This document describes an extended version of the EVE editor that has been tailored to the general Starlink user's requirements. This extended editor is STarlink Eve or STEve, and this document (along with it's introductory companion SUN/125) describes this editor, and offers additional help, advice and tips on general EVE usage.
Mroczkowski, Alison L; Sánchez, Bernadette
2015-09-01
The present study used resilience theory to explore relationships among perceived racial discrimination, ethnic identity, gender, and economic value of education (EVE) among urban, low-income, Latina/o youth. It was expected that racial discrimination would predict poorer perceptions of the EVE among Latina/o adolescents. Ethnic identity was hypothesized to buffer the negative effect of racial discrimination on Latina/o students' EVE. The participants in this study were 396 urban, low-income Latina/o high school students from a large, Midwestern city who completed surveys in both 9th- and 10th-grade. Structural equation modeling was used to test the relationships among racial discrimination, ethnic identity, and EVE. Results supported a protective model of resilience. Specifically, ethnic identity served as a protective factor by buffering the negative effect of perceived racial discrimination on EVE for male participants. The present study is the first to examine ethnic identity as a buffer of racial discrimination on EVE among Latina/o high school students. Future directions and implications are discussed.
Meet EPA Biologist Laura Jackson, Ph.D.
Research Biologist Laura Jackson, Ph.D., has worked for the EPA for 22 years, leading research initiatives in a diversity of disciplines, including environmental monitoring, land use planning, and the impacts that urbanization has on an area's ecology
Hao, Yanni; Lin, Peggy L; Xie, Jipan; Li, Nanxin; Koo, Valerie; Ohashi, Erika; Wu, Eric Q; Rogerio, Jaqueline
2015-08-01
Assessing real-world effectiveness of everolimus-based therapy (EVE) versus fulvestrant monotherapy (FUL) among postmenopausal women with hormone receptor-positive (HR(+))/HER2(-) metastatic breast cancer (mBC) after progression on nonsteroidal aromatase inhibitor (NSAI). Medical charts of community-based patients who received EVE or FUL for mBC after NSAI were examined. Progression-free survival (PFS), time on treatment and time to chemotherapy were compared using Kaplan-Meier curves and Cox proportional hazards models adjusting for line of therapy and patient characteristics. 192 patients received EVE and 156 FUL. After adjusting for patient characteristics, EVE was associated with significantly longer PFS than FUL (hazard ratio: 0.71; p = 0.045). EVE was associated with better PFS than FUL among NSAI-refractory postmenopausal HR(+)/HER2(-) mBC patients.
Overview of EVE - the event visualization environment of ROOT
NASA Astrophysics Data System (ADS)
Tadel, Matevž
2010-04-01
EVE is a high-level visualization library using ROOT's data-processing, GUI and OpenGL interfaces. It is designed as a framework for object management offering hierarchical data organization, object interaction and visualization via GUI and OpenGL representations. Automatic creation of 2D projected views is also supported. On the other hand, it can serve as an event visualization toolkit satisfying most HEP requirements: visualization of geometry, simulated and reconstructed data such as hits, clusters, tracks and calorimeter information. Special classes are available for visualization of raw-data. Object-interaction layer allows for easy selection and highlighting of objects and their derived representations (projections) across several views (3D, Rho-Z, R-Phi). Object-specific tooltips are provided in both GUI and GL views. The visual-configuration layer of EVE is built around a data-base of template objects that can be applied to specific instances of visualization objects to ensure consistent object presentation. The data-base can be retrieved from a file, edited during the framework operation and stored to file. EVE prototype was developed within the ALICE collaboration and has been included into ROOT in December 2007. Since then all EVE components have reached maturity. EVE is used as the base of AliEve visualization framework in ALICE, Firework physics-oriented event-display in CMS, and as the visualization engine of FairRoot in FAIR.
2005-01-01
Program Integration PROJECT LEADERS: Bernard Rostker and Laura Miller 20 RAND National Security Research Division The more intensive use of the...Lim, Laura Werber Castaneda, Daniela Golinelli. MG-196-OSD. NOTE: MG stands for monograph; CF for confer- ence proceedings; CT for congressional
NASA Technical Reports Server (NTRS)
Hock, R. A.; Woods, T. N.; Crotser, D.; Eparvier, F. G.; Woodraska, D. L.; Chamberlin, P. C.; Woods, E. C.
2010-01-01
The NASA Solar Dynamics Observatory (SDO), scheduled for launch in early 2010, incorporates a suite of instruments including the Extreme Ultraviolet Variability Experiment (EVE). EVE has multiple instruments including the Multiple Extreme ultraviolet Grating Spectrographs (MEGS) A, B, and P instruments, the Solar Aspect Monitor (SAM), and the Extreme ultraviolet SpectroPhotometer (ESP). The radiometric calibration of EVE, necessary to convert the instrument counts to physical units, was performed at the National Institute of Standards and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF III) located in Gaithersburg, Maryland. This paper presents the results and derived accuracy of this radiometric calibration for the MEGS A, B, P, and SAM instruments, while the calibration of the ESP instrument is addressed by Didkovsky et al. . In addition, solar measurements that were taken on 14 April 2008, during the NASA 36.240 sounding-rocket flight, are shown for the prototype EVE instruments.
User's Manual for the Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA)
NASA Technical Reports Server (NTRS)
Gnoffo, Peter A.; Cheatwood, F. McNeil
1996-01-01
This user's manual provides detailed instructions for the installation and the application of version 4.1 of the Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA). Also provides simulation of flow field in thermochemical nonequilibrium around vehicles traveling at hypersonic velocities through the atmosphere. Earlier versions of LAURA were predominantly research codes, and they had minimal (or no) documentation. This manual describes UNIX-based utilities for customizing the code for special applications that also minimize system resource requirements. The algorithm is reviewed, and the various program options are related to specific equations and variables in the theoretical development.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-23
... in past years but the fireworks display will move to a new location in the Mobile Channel beginning...-AA00 Eighth Coast Guard District Annual Safety Zones; New Year's Eve Celebration/City of Mobile; Mobile... enforce the City of Mobile New Year's Eve Celebration safety zone in the Mobile Channel, Mobile, AL from...
Network Performance Modeling, Design and Dimensioning Methodologies
2000-01-01
Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the...failing to comply with a collection of information if it does not display a currently valid OMB control number. 1 . REPORT DATE 2000 2. REPORT TYPE 3...eveEeEeveEeveEeEeveEe,eveEeveEeúèOÍ ÏReéÏ 8i RSQR R�eEeEeve,eEeveEeveEeEeveEeveEe,eveEeEeveEeveEeEeveEe,eveEeveEeúèOæ Í 6H¼2 .),576& ;D8¢;= 1 1u$B+.$0#2
Lee, S W; Jeong, B S; Choi, J; Kim, J-W
2015-01-01
Men tend to have greater positive responses than women to explicit visual erotic stimuli (EVES). However, it remains unclear, which brain network makes men more sensitive to EVES and which factors contribute to the brain network activity. In this study, we aimed to assess the effect of sex difference on brain connectivity patterns by EVES. We also investigated the association of testosterone with brain connection that showed the effects of sex difference. During functional magnetic resonance imaging scans, 14 males and 14 females were asked to see alternating blocks of pictures that were either erotic or non-erotic. Psychophysiological interaction analysis was performed to investigate the functional connectivity of the nucleus accumbens (NA) as it related to EVES. Men showed significantly greater EVES-specific functional connection between the right NA and the right lateral occipital cortex (LOC). In addition, the right NA and the right LOC network activity was positively correlated with the plasma testosterone level in men. Our results suggest that the reason men are sensitive to EVES is the increased interaction in the visual reward networks, which is modulated by their plasma testosterone level.
Search Site submit About Us Los Alamos National LaboratoryRichard P. Feynman Center for Innovation Innovation protecting tomorrow Los Alamos National Laboratory The Richard P. Feynman Center for Innovation . thumbnail of Energy and Subsurface Laura Barber, Business Development Laura Barber Energy: Los Alamos is
2012-01-01
Background Annelids and arthropods each possess a segmented body. Whether this similarity represents an evolutionary convergence or inheritance from a common segmented ancestor is the subject of ongoing investigation. Methods To investigate whether annelids and arthropods share molecular components that control segmentation, we isolated orthologs of the Drosophila melanogaster pair-rule genes, runt, paired (Pax3/7) and eve, from the polychaete annelid Capitella teleta and used whole mount in situ hybridization to characterize their expression patterns. Results When segments first appear, expression of the single C. teleta runt ortholog is only detected in the brain. Later, Ct-runt is expressed in the ventral nerve cord, foregut and hindgut. Analysis of Pax genes in the C. teleta genome reveals the presence of a single Pax3/7 ortholog. Ct-Pax3/7 is initially detected in the mid-body prior to segmentation, but is restricted to two longitudinal bands in the ventral ectoderm. Each of the two C. teleta eve orthologs has a unique and complex expression pattern, although there is partial overlap in several tissues. Prior to and during segment formation, Ct-eve1 and Ct-eve2 are both expressed in the bilaterial pair of mesoteloblasts, while Ct-eve1 is expressed in the descendant mesodermal band cells. At later stages, Ct-eve2 is expressed in the central and peripheral nervous system, and in mesoderm along the dorsal midline. In late stage larvae and adults, Ct-eve1 and Ct-eve2 are expressed in the posterior growth zone. Conclusions C. teleta eve, Pax3/7 and runt homologs all have distinct expression patterns and share expression domains with homologs from other bilaterians. None of the pair-rule orthologs examined in C. teleta exhibit segmental or pair-rule stripes of expression in the ectoderm or mesoderm, consistent with an independent origin of segmentation between annelids and arthropods. PMID:22510249
Zarin, Aref Arzan; Asadzadeh, Jamshid; Hokamp, Karsten; McCartney, Daniel; Yang, Long; Bashaw, Greg J; Labrador, Juan-Pablo
2014-03-19
Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. Using mRNA profiling, we identified the complement of membrane molecules regulated by the homeobox TF Even-skipped (Eve), the major determinant of dorsal motor neuron (dMN) identity in Drosophila. Combinatorial loss- and gain-of-function genetic analyses of Eve target genes indicate that the integrated actions of attractive, repulsive, and adhesive molecules direct eve-dependent dMN axon guidance. Furthermore, combined misexpression of Eve target genes is sufficient to partially restore CNS exit and can convert the guidance behavior of interneurons to that of dMNs. Finally, we show that a network of TFs, comprised of eve, zfh1, and grain, induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dMN axons. Copyright © 2014 Elsevier Inc. All rights reserved.
Zarin, Aref Arzan; Asadzadeh, Jamshid; Hokamp, Karsten; McCartney, Daniel; Yang, Long; Bashaw, Greg J.; Labrador, Juan-Pablo
2014-01-01
SUMMARY Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. Using mRNA profiling, we identified the complement of membrane molecules regulated by the homeobox TF Even-skipped (Eve), the major determinant of dorsal motor neuron (dMN) identity in Drosophila. Combinatorial loss- and gain-of-function genetic analyses of Eve target genes indicate that the integrated actions of attractive, repulsive, and adhesive molecules direct eve-dependent dMN axon guidance. Furthermore, combined misexpression of Eve target genes is sufficient to partially restore CNS exit and can convert the guidance behavior of interneurons to that of dMNs. Finally, we show that a network of TFs, comprised of eve, zfh1, and grain, induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dMN axons. PMID:24560702
NASA Technical Reports Server (NTRS)
Woods, T. N.; Eparvier, F. G.; Hock, R.; Jones, A. R.; Woodraska, D.; Judge, D.; Didkovsky, L.; Lean, J.; Mariska, J.; Warren, H.;
2010-01-01
The highly variable solar extreme ultraviolet (EUV) radiation is the major energy input to the Earth's upper atmosphere, strongly impacting the geospace environment, affecting satellite operations, communications, and navigation. The Extreme ultraviolet Variability Experiment (EVE) onboard the NASA Solar Dynamics Observatory (SDO) will measure the solar EUV irradiance from 0.1 to 105 nm with unprecedented spectral resolution (0.1 nm), temporal cadence (ten seconds), and accuracy (20%). EVE includes several irradiance instruments: The Multiple EUV Grating Spectrographs (MEGS)-A is a grazingincidence spectrograph that measures the solar EUV irradiance in the 5 to 37 nm range with 0.1-nm resolution, and the MEGS-B is a normal-incidence, dual-pass spectrograph that measures the solar EUV irradiance in the 35 to 105 nm range with 0.1-nm resolution. To provide MEGS in-flight calibration, the EUV SpectroPhotometer (ESP) measures the solar EUV irradiance in broadbands between 0.1 and 39 nm, and a MEGS-Photometer measures the Sun s bright hydrogen emission at 121.6 nm. The EVE data products include a near real-time space-weather product (Level 0C), which provides the solar EUV irradiance in specific bands and also spectra in 0.1-nm intervals with a cadence of one minute and with a time delay of less than 15 minutes. The EVE higher-level products are Level 2 with the solar EUV irradiance at higher time cadence (0.25 seconds for photometers and ten seconds for spectrographs) and Level 3 with averages of the solar irradiance over a day and over each one-hour period. The EVE team also plans to advance existing models of solar EUV irradiance and to operationally use the EVE measurements in models of Earth s ionosphere and thermosphere. Improved understanding of the evolution of solar flares and extending the various models to incorporate solar flare events are high priorities for the EVE team.
Pritchard, Kathleen I; Burris, Howard A; Ito, Yoshinori; Rugo, Hope S; Dakhil, Shaker; Hortobagyi, Gabriel N; Campone, Mario; Csöszi, Tibor; Baselga, José; Puttawibul, Puttisak; Piccart, Martine; Heng, Daniel; Noguchi, Shinzaburo; Srimuninnimit, Vichien; Bourgeois, Hugues; Gonzalez Martin, Antonio; Osborne, Karen; Panneerselvam, Ashok; Taran, Tetiana; Sahmoud, Tarek; Gnant, Michael
2013-12-01
Postmenopausal women with hormone receptor-positive (HR(+)) breast cancer in whom disease progresses or there is recurrence while taking a nonsteroidal aromatase inhibitor (NSAI) are usually treated with exemestane (EXE), but no single standard of care exists in this setting. The BOLERO-2 trial demonstrated that adding everolimus (EVE) to EXE improved progression-free survival (PFS) while maintaining quality of life when compared with EXE alone. Because many women with HR(+) advanced breast cancer are elderly, the tolerability profile of EVE plus EXE in this population is of interest. BOLERO-2, a phase III randomized trial, compared EVE (10 mg/d) and placebo (PBO), both plus EXE (25 mg/d), in 724 postmenopausal women with HR(+) advanced breast cancer recurring/progressing after treatment with NSAIs. Safety and efficacy data in elderly patients are reported at 18-month median follow-up. Baseline disease characteristics and treatment histories among the elderly subsets (≥ 65 years, n = 275; ≥ 70 years, n = 164) were generally comparable with younger patients. The addition of EVE to EXE improved PFS regardless of age (hazard ratio, 0.59 [≥ 65 years] and 0.45 [≥ 70 years]). Adverse events (AEs) of special interest (all grades) that occurred more frequently with EVE than with PBO included stomatitis, infections, rash, pneumonitis, and hyperglycemia. Elderly EVE-treated patients had similar incidences of these AEs as did younger patients but had more on-treatment deaths. Adding EVE to EXE offers substantially improved PFS over EXE and was generally well tolerated in elderly patients with HR(+) advanced breast cancer. Careful monitoring and appropriate dose reductions or interruptions for AE management are recommended during treatment with EVE in this patient population. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Laura Carnell: The Woman behind the Founder's Myth at Temple University
ERIC Educational Resources Information Center
Bakley, Annette McMenamin
2014-01-01
Using archival materials from the early years of Temple University's history at the Special Collections Research Center, Templana Collection, at Samuel Paley Library of Temple University as well as historical periodicals, this project established a biographical sketch of Associate President Laura Carnell and examined her influence on the…
Through the Eyes of Laura Ingalls Wilder
ERIC Educational Resources Information Center
Dowd, Diane
2006-01-01
Laura Ingalls Wilder's purpose in writing the "Little House" books for children illustrate the day-to-day experiences of a girl, and her stories provide glimpses into a young mind's conceptualization of aspects of living that are mathematical in nature, such as geometric and quantitative conceptions, logical reasoning and communication, and…
Planning for Success: Developing an Economic Planning Cell for the Operational Level Commander
2011-05-04
Laura Landes, “ Follow the Money : The Army Finance Corps and Iraqi Financial Independence,” Military Review (March – April 2008): 85 ii Joint...accessed 23 March, 2011). Landes, Laura. “ Follow the Money : The Army Finance Corps and Iraqi Financial Independence,” Military Review (March
ERIC Educational Resources Information Center
Hassenpflug, Ann
2012-01-01
A high school drama coach informs assistant principal Laura Madison that the money students earned through fund-raising activities seems to have vanished and that the male assistant principal may be involved in the disappearance of the funds. Laura has to determine how to address this situation. She considers her past experiences with problematic…
Endogenous Retrovirus 3 – History, Physiology, and Pathology
Bustamante Rivera, Yomara Y.; Brütting, Christine; Schmidt, Caroline; Volkmer, Ines; Staege, Martin S.
2018-01-01
Endogenous viral elements (EVE) seem to be present in all eukaryotic genomes. The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini. Conservation of ERV3 in most of the investigated Catarrhini and the expression pattern in normal tissues suggest a putative physiological role of ERV3. On the other hand, ERV3 has been implicated in the pathogenesis of auto-immunity and cancer. In the present review we summarize knowledge about this interesting EVE. We propose the model that expression of ERV3 (and probably other EVE loci) under pathological conditions might be part of a metazoan SOS response. PMID:29379485
Extended analysis of the Trojan-horse attack in quantum key distribution
NASA Astrophysics Data System (ADS)
Vinay, Scott E.; Kok, Pieter
2018-04-01
The discrete-variable quantum key distribution protocols based on the 1984 protocol of Bennett and Brassard (BB84) are known to be secure against an eavesdropper, Eve, intercepting the flying qubits and performing any quantum operation on them. However, these protocols may still be vulnerable to side-channel attacks. We investigate the Trojan-horse side-channel attack where Eve sends her own state into Alice's apparatus and measures the reflected state to estimate the key. We prove that the separable coherent state is optimal for Eve among the class of multimode Gaussian attack states, even in the presence of thermal noise. We then provide a bound on the secret key rate in the case where Eve may use any separable state.
EPO for the NASA SDO Extreme Ultraviolet Variability Experiment (EVE) Learning Suite for Educators
NASA Astrophysics Data System (ADS)
Kellagher, Emily; Scherrer, D. K.
2013-07-01
EVE Education and Public Outreach (EPO) promotes an understanding of the process of science and concepts within solar science and sun-earth connections. EVE EPO also features working scientists, current research and career awareness. One of the highlights for of this years projects is the digitization of solar lessons and the collaboration with the other instrument teams to develop new resources for students and educators. Digital lesson suite: EVE EPO has taken the best solar lessons and reworked then to make then more engaging, to reflect SDO data and made them SMARTboard compatible. We are creating a website that Students and teachers can access these lesson and use them online or download them. Project team collaboration: The SDO instruments (EVE, AIA and HMI) teams have created a comic book series for upper elementary and middle school students with the SDO mascot Camilla. These comics may be printed or read on mobile devices. Many teachers are looking for resources to use with their students via the Ipad so our collaboration helps supply teachers with a great resource that teachers about solar concepts and helps dispel solar misconceptions.Abstract (2,250 Maximum Characters): EVE Education and Public Outreach (EPO) promotes an understanding of the process of science and concepts within solar science and sun-earth connections. EVE EPO also features working scientists, current research and career awareness. One of the highlights for of this years projects is the digitization of solar lessons and the collaboration with the other instrument teams to develop new resources for students and educators. Digital lesson suite: EVE EPO has taken the best solar lessons and reworked then to make then more engaging, to reflect SDO data and made them SMARTboard compatible. We are creating a website that Students and teachers can access these lesson and use them online or download them. Project team collaboration: The SDO instruments (EVE, AIA and HMI) teams have created a comic book series for upper elementary and middle school students with the SDO mascot Camilla. These comics may be printed or read on mobile devices. Many teachers are looking for resources to use with their students via the Ipad so our collaboration helps supply teachers with a great resource that teachers about solar concepts and helps dispel solar misconceptions.
Creating Value from Innovation: Laura Gordon-Murnane--Bureau of National Affairs
ERIC Educational Resources Information Center
Library Journal, 2005
2005-01-01
Some corporate executives regard their libraries as black holes that just consume company resources, but thanks to Laura Gordon-Murnane, executives at the Bureau of National Affairs (BNA) know their library actively adds value to the company. As web master for BNA's intranet, Gordon-Murnane creates information tools, databases, and products for…
Gender Transformations and Colonial Displacements in Laura Antillano's "Tuna de mar"
ERIC Educational Resources Information Center
Reid, Alana
2015-01-01
This paper examines the trajectories of two characters in Laura Antillano's short story, "Tuna de mar" (1991), as they navigate interrelated systems of power and attempt to position themselves closer to, or further away from, the margins. Set in the late eighteenth century, the tale features a female protagonist who escapes prostitution…
Taylor, John J; Bambrick, Rachel; Brand, Andrew; Bray, Nathan; Dutton, Michelle; Harper, Robert A; Hoare, Zoe; Ryan, Barbara; Edwards, Rhiannon T; Waterman, Heather; Dickinson, Christine
2017-07-01
To compare the performance of near vision activities using additional portable electronic vision enhancement systems (p-EVES), to using optical magnifiers alone, by individuals with visual impairment. A total of 100 experienced optical aid users were recruited from low vision clinics at Manchester Royal Eye Hospital, Manchester, UK, to a prospective two-arm cross-over randomised controlled trial. Reading, performance of near vision activities, and device usage were evaluated at baseline; and at the end of each study arm (Intervention A: existing optical aids plus p-EVES; Intervention B: optical aids only) which was after 2 and 4 months. A total of 82 participants completed the study. Overall, maximum reading speed for high contrast sentences was not statistically significantly different for optical aids and p-EVES, although the critical print size and threshold print size which could be accessed with p-EVES were statistically significantly smaller (p < 0.001 in both cases). The optical aids were used for a larger number of tasks (p < 0.001), and used more frequently (p < 0.001). However p-EVES were preferred for leisure reading by 70% of participants, and allowed longer duration of reading (p < 0.001). During the study arm when they had a p-EVES device, participants were able to carry out more tasks independently (p < 0.001), and reported less difficulty with a range of near vision activities (p < 0.001). The study provides evidence that p-EVES devices can play a useful role in supplementing the range of low vision aids used to reduce activity limitation for near vision tasks. © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists.
A New Paradigm Hidden in Steganography
2000-01-01
In steganography , we do not make the \\strong" assumption that Eve has knowledge of the steganographic algorithm . This is why there may, or may not be...the n least signi cant bits ( LSB ) of each pixel in the cov- erimage, with the n most signi cant bits (MSB) from the corresponding pixel of the image to...e.g., 2 LSB are (0,0) ) to 3 (e.g., 2 LSB are (1,1) ), it is visually impossible for Eve to detect the steganography . Of course, if Eve has knowl
AltitudeOmics: The Basic Biology of Human Acclimatization to High Altitude
2013-09-01
News Physiol Sci 17: 17–21, 2002. 62. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN...transcranial magnetic stimulation. J Physiol 551, 661-671. Willie, C. K., Macleod, D. B., Shaw , A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., Ikeda...blood flow. Davis, Philadelphia. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA & Ainslie PN
Parvovirus-Derived Endogenous Viral Elements in Two South American Rodent Genomes
2014-01-01
We describe endogenous viral elements (EVEs) derived from parvoviruses (family Parvoviridae) in the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon degus). The novel EVEs include dependovirus-related elements and representatives of a clearly distinct parvovirus lineage that also has endogenous representatives in marsupial genomes. In the degu, one dependovirus-derived EVE was found to carry an intact reading frame and was differentially expressed in vivo, with increased expression in the liver. PMID:25078696
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-23
... Collection: DS-7652, U.S. National Commission for UNESCO Laura W. Bush Traveling Fellowship ACTION: Notice of....S. National Commission for UNESCO Laura W. Bush Traveling Fellowship. OMB Control Number: 1405-0180... UNESCO (IO/UNESCO). Form Number: DS-7646. Respondents: U.S. college and university students applying for...
Teaching Laura Kipnis's "Love's Labors" in "Ways of Reading"
ERIC Educational Resources Information Center
Fike, Matthew A.
2013-01-01
This essay describes a method of teaching a very challenging anthology piece: Laura Kipnis's "Love's Labors" (chapter 1 of her 2003 "Against Love: A Polemic"). The method, although designed for a critical thinking course, should also provide resources for those who teach Kipnis's work in writing courses. Using…
Campone, Mario; Bachelot, Thomas; Gnant, Michael; Deleu, Ines; Rugo, Hope S; Pistilli, Barbara; Noguchi, Shinzaburo; Shtivelband, Mikhail; Pritchard, Kathleen I; Provencher, Louise; Burris, Howard A; Hart, Lowell; Melichar, Bohuslav; Hortobagyi, Gabriel N; Arena, Francis; Baselga, José; Panneerselvam, Ashok; Héniquez, Aurelia; El-Hashimyt, Mona; Taran, Tetiana; Sahmoud, Tarek; Piccart, Martine
2013-08-01
Everolimus (EVE; an inhibitor of mammalian target of rapamycin [mTOR]) enhances treatment options for postmenopausal women with hormone-receptor-positive (HR(+)), human epidermal growth factor receptor-2-negative (HER2(-)) advanced breast cancer (ABC) who progress on a non-steroidal aromatase inhibitor (NSAI). This is especially true for patients with visceral disease, which is associated with poor prognosis. The BOLERO-2 (Breast cancer trial of OraLEveROlimus-2) trial showed that combination treatment with EVE and exemestane (EXE) versus placebo (PBO)+EXE prolonged progression-free survival (PFS) by both investigator (7.8 versus 3.2 months, respectively) and independent (11.0 versus 4.1 months, respectively) central assessment in postmenopausal women with HR(+), HER2(-) ABC recurring/progressing during/after NSAI therapy. The BOLERO-2 trial included a substantial proportion of patients with visceral metastases (56%). Prespecified exploratory subgroup analysis conducted to evaluate the efficacy and safety of EVE+EXE versus PBO+EXE in a prospectively defined subgroup of patients with visceral metastases. At a median follow-up of 18 months, EVE+EXE significantly prolonged median PFS compared with PBO+EXE both in patients with visceral metastases (N=406; 6.8 versus 2.8 months) and in those without visceral metastases (N=318; 9.9 versus 4.2 months). Improvements in PFS with EVE+EXE versus PBO+EXE were also observed in patients with visceral metastases regardless of Eastern Cooperative Oncology Group performance status (ECOG PS). Patients with visceral metastases and ECOG PS 0 had a median PFS of 6.8 months with EVE+EXE versus 2.8 months with PBO+EXE. Among patients with visceral metastases and ECOG PS ≥1, EVE+EXE treatment more than tripled median PFS compared with PBO+EXE (6.8 versus 1.5 months). Adding EVE to EXE markedly extended PFS by ≥4 months among patients with HR(+) HER2(-) ABC regardless of the presence of visceral metastases. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
NASA Astrophysics Data System (ADS)
Wieman, S. R.; Didkovsky, L. V.; Woods, T. N.; Jones, A. R.; Caspi, A.; Warren, H. P.
2015-12-01
Observations of solar active regions (ARs) in the soft x-ray spectral range (0.5 to 3.0 nm) were made on sounding rocket flight NASA 36.290 using a modified Solar Aspect Monitor (SAM), a pinhole camera on the EUV Variability Experiment (EVE) sounding rocket instrument. The suite of EVE rocket instruments is designed for under-flight calibrations of the orbital EVE on SDO. While the sounding rocket EVE instrument is for the most part a duplicate of the EVE on SDO, the SAM channel on the rocket version was modified in 2012 to include a free-standing transmission grating so that it could provide spectrally resolved images of the solar disk with the best signal to noise ratio for the brightest features on it, such as ARs. Calibrations of the EVE sounding rocket instrument at the National Institute of Standards and Technology Synchrotron Ultraviolet Radiation Facility (NIST SURF) have provided a measurement of the SAM absolute spectral response function and a mapping of wavelength separation in the grating diffraction pattern. For solar observations, this spectral separation is on a similar scale to the spatial size of the AR on the CCD, so dispersed AR images associated with emission lines of similar wavelength tend to overlap. Furthermore, SAM shares a CCD detector with MEGS-A, a separate EVE spectrometer channel, and artifacts of the MEGS-A signal (a set of bright spectral lines) appear in the SAM images. For these reasons some processing and analysis of the solar images obtained by SAM must be performed in order to determine spectra of the observed ARs. We present a method for determining AR spectra from the SAM rocket images and report initial soft X-ray spectra for two of the major active regions (AR11877 and AR11875) observed on flight 36.290 on 21 October 2013 at about 18:30 UT. We also compare our results with concurrent measurements from other solar soft x-ray instrumentation.
NASA Technical Reports Server (NTRS)
Chamberlin, Phillip Clyde
2016-01-01
The EUV Variability Experiment (EVE) onboard the Solar Dynamics Observatory has provided unprecedented measurements of the solar EUV irradiance at high temporal cadence with good spectral resolution and range since May 2010. The main purpose of EVE was to connect the Sun to the Earth by providing measurements of the EUV irradianceas a driver for space weather and Living With a Star studies, but after launch the instrument has demonstrated the significance of its measurements in contributing to studies looking at the sources of solar variability for pure solar physics purposes. This paper expands upon previous findings that EVE can in fact measure wavelength shifts during solar eruptive events and therefore provide Doppler velocities for plasma at all temperatures throughout the solar atmosphere from the chromosphere to hot flaring temperatures. This process is not straightforward as EVE was not designed or optimized for these types of measurements. In this paper we describe the many detailed instrumental characterizations needed to eliminate the optical effects in order to provide an absolute baseline for the Doppler shift studies. An example is given of a solar eruption on 7 September 2011 (SOL2011-09-07), associated with an X1.2 flare, where EVE Doppler analysis shows plasma ejected from the Sun in the He II 30.38 nm emission at a velocity of almost 120 km s(exp -1) along the line-of-sight.
Everolimus plus exemestane as first-line therapy in HR⁺, HER2⁻ advanced breast cancer in BOLERO-2.
Beck, J Thaddeus; Hortobagyi, Gabriel N; Campone, Mario; Lebrun, Fabienne; Deleu, Ines; Rugo, Hope S; Pistilli, Barbara; Masuda, Norikazu; Hart, Lowell; Melichar, Bohuslav; Dakhil, Shaker; Geberth, Matthias; Nunzi, Martina; Heng, Daniel Y C; Brechenmacher, Thomas; El-Hashimy, Mona; Douma, Shyanne; Ringeisen, Francois; Piccart, Martine
2014-02-01
The present exploratory analysis examined the efficacy, safety, and quality-of-life effects of everolimus (EVE) + exemestane (EXE) in the subgroup of patients in BOLERO-2 whose last treatment before study entry was in the (neo)adjuvant setting. In BOLERO-2, patients with hormone-receptor-positive (HR(+)), human epidermal growth factor receptor-2-negative (HER2(-)) advanced breast cancer recurring/progressing after a nonsteroidal aromatase inhibitor (NSAI) were randomly assigned (2:1) to receive EVE (10 mg/day) + EXE (25 mg/day) or placebo (PBO) + EXE. The primary endpoint was progression-free survival (PFS) by local assessment. Overall, 137 patients received first-line EVE + EXE (n = 100) or PBO + EXE (n = 37). Median PFS by local investigator assessment nearly tripled to 11.5 months with EVE + EXE from 4.1 months with PBO + EXE (hazard ratio = 0.39; 95 % CI 0.25-0.62), while maintaining quality of life. This was confirmed by central assessment (15.2 vs 4.2 months; hazard ratio = 0.32; 95 % CI 0.18-0.57). The marked PFS improvement in patients receiving EVE + EXE as first-line therapy for disease recurrence during or after (neo)adjuvant NSAI therapy supports the efficacy of this combination in the first-line setting. Furthermore, the results highlight the potential benefit of early introduction of EVE + EXE in the management of HR(+), HER2(-) advanced breast cancer in postmenopausal patients.
ACHP | News | Mrs. Laura Bush Announces Preserve America Community
Sept. 15, 2003, Mobile, AlabamaÂMrs. Laura Bush today announced details of two new key components of continue to build upon. Mobile is a great example of a community that is using its past to build a better recognition program included ACHP member Emily Summers; Mobile, AL, mayor Mike Dow; Secretary of the Interior
Preparing Children To Read and Learn: An Education Initiative of Laura Bush.
ERIC Educational Resources Information Center
Department of Education, Washington, DC.
Noting that teaching reading is one of the Bush Administration's top domestic priorities, this pamphlet introduces the Ready to Read, Ready to Learn education initiative of First Lady Laura Bush. The goals of the initiative are to ensure that all young children are ready to read and learn when they enter their first classroom, and to ensure that…
Parvovirus-derived endogenous viral elements in two South American rodent genomes.
Arriagada, Gloria; Gifford, Robert J
2014-10-01
We describe endogenous viral elements (EVEs) derived from parvoviruses (family Parvoviridae) in the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon degus). The novel EVEs include dependovirus-related elements and representatives of a clearly distinct parvovirus lineage that also has endogenous representatives in marsupial genomes. In the degu, one dependovirus-derived EVE was found to carry an intact reading frame and was differentially expressed in vivo, with increased expression in the liver. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Bray, Nathan; Brand, Andrew; Taylor, John; Hoare, Zoe; Dickinson, Christine; Edwards, Rhiannon T
2017-08-01
To determine the incremental cost-effectiveness of portable electronic vision enhancement system (p-EVES) devices compared with optical low vision aids (LVAs), for improving near vision visual function, quality of life and well-being of people with a visual impairment. An AB/BA randomized crossover trial design was used. Eighty-two participants completed the study. Participants were current users of optical LVAs who had not tried a p-EVES device before and had a stable visual impairment. The trial intervention was the addition of a p-EVES device to the participant's existing optical LVA(s) for 2 months, and the control intervention was optical LVA use only, for 2 months. Cost-effectiveness and cost-utility analyses were conducted from a societal perspective. The mean cost of the p-EVES intervention was £448. Carer costs were £30 (4.46 hr) less for the p-EVES intervention compared with the LVA only control. The mean difference in total costs was £417. Bootstrapping gave an incremental cost-effectiveness ratio (ICER) of £736 (95% CI £481 to £1525) for a 7% improvement in near vision visual function. Cost per quality-adjusted life year (QALY) ranged from £56 991 (lower 95% CI = £19 801) to £66 490 (lower 95% CI = £23 055). Sensitivity analysis varying the commercial price of the p-EVES device reduced ICERs by up to 75%, with cost per QALYs falling below £30 000. Portable electronic vision enhancement system (p-EVES) devices are likely to be a cost-effective use of healthcare resources for improving near vision visual function, but this does not translate into cost-effective improvements in quality of life, capability or well-being. © 2016 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation and European Association for Vision & Eye Research.
The Adam and Eve Robot Scientists for the Automated Discovery of Scientific Knowledge
NASA Astrophysics Data System (ADS)
King, Ross
A Robot Scientist is a physically implemented robotic system that applies techniques from artificial intelligence to execute cycles of automated scientific experimentation. A Robot Scientist can automatically execute cycles of hypothesis formation, selection of efficient experiments to discriminate between hypotheses, execution of experiments using laboratory automation equipment, and analysis of results. The motivation for developing Robot Scientists is to better understand science, and to make scientific research more efficient. The Robot Scientist `Adam' was the first machine to autonomously discover scientific knowledge: both form and experimentally confirm novel hypotheses. Adam worked in the domain of yeast functional genomics. The Robot Scientist `Eve' was originally developed to automate early-stage drug development, with specific application to neglected tropical disease such as malaria, African sleeping sickness, etc. We are now adapting Eve to work with on cancer. We are also teaching Eve to autonomously extract information from the scientific literature.
TIME-DEPENDENT DENSITY DIAGNOSTICS OF SOLAR FLARE PLASMAS USING SDO/EVE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Milligan, Ryan O.; Kennedy, Michael B.; Mathioudakis, Mihalis
2012-08-10
Temporally resolved electron density measurements of solar flare plasmas are presented using data from the EUV Variability Experiment (EVE) on board the Solar Dynamics Observatory. The EVE spectral range contains emission lines formed between 10{sup 4} and 10{sup 7} K, including transitions from highly ionized iron ({approx}>10 MK). Using three density-sensitive Fe XXI ratios, peak electron densities of 10{sup 11.2}-10{sup 12.1} cm{sup -3} were found during four X-class flares. While previous measurements of densities at such high temperatures were made at only one point during a flaring event, EVE now allows the temporal evolution of these high-temperature densities to bemore » determined at 10 s cadence. A comparison with GOES data revealed that the peak of the density time profiles for each line ratio correlated well with that of the emission measure time profile for each of the events studied.« less
Applications of the Galton Watson process to human DNA evolution and demography
NASA Astrophysics Data System (ADS)
Neves, Armando G. M.; Moreira, Carlos H. C.
2006-08-01
We show that the problem of existence of a mitochondrial Eve can be understood as an application of the Galton-Watson process and presents interesting analogies with critical phenomena in Statistical Mechanics. In the approximation of small survival probability, and assuming limited progeny, we are able to find for a genealogic tree the maximum and minimum survival probabilities over all probability distributions for the number of children per woman constrained to a given mean. As a consequence, we can relate existence of a mitochondrial Eve to quantitative demographic data of early mankind. In particular, we show that a mitochondrial Eve may exist even in an exponentially growing population, provided that the mean number of children per woman Nbar is constrained to a small range depending on the probability p that a child is a female. Assuming that the value p≈0.488 valid nowadays has remained fixed for thousands of generations, the range where a mitochondrial Eve occurs with sizeable probability is 2.0492
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jiang, Sen, E-mail: jasfly77@vip.163.com; Sun, Xi-Wen, E-mail: xwsun@citiz.net; Yu, Dong, E-mail: yudong_mail@126.com
2013-05-15
PurposeOur experience with endovascular embolization (EVE) of the bronchial artery (BA) originating from the upper portion of the aortic arch (AA) in six patients is described.MethodsAltogether, 818 patients with hemoptysis underwent multidetector row computed tomography angiography (MDCTA) before EVE or AA angiography during EVE. Aberrant BAs originating from the upper portion of the AA were the source of massive hemoptysis in six patients (0.73 %). MDCT angiograms and/or Digital subtraction angiograms were retrospectively reviewed. Selective catheterization and embolization were performed.ResultsThe ostia of the BAs were located on the superior surface of the AA between the brachiocephalic trunk and left common carotidmore » artery in three patients, the junction of the aorta and medial surface of the left subclavian artery in two, and the posterior wall of the upper portion of the AA in one. The six BAs comprised two common trunks, three single right sides, and one single left side. The targeted vessels were successfully catheterized and embolized by a coaxial microcatheter system using polyvinyl alcohol particles. Other pathologic BAs and nonbronchial systemic arteries also were embolized. Bleeding was immediately controlled in all patients with no recurrence of hemoptysis. No procedure-related complications occurred.ConclusionsApplication of EVE of anomalous origin of BAs in patients with hemoptysis is important, as demonstrated in the six reported patients. MDCTA before EVE or AA angiography during EVE is critical to avoid missing a rare aberrant BA originating from the upper portion of the AA.« less
The Actions of One Inspire the Power of Many: Laura Briley, Day Schools, Tulsa, Oklahoma
ERIC Educational Resources Information Center
Gonzalez-Mena, Janet
2010-01-01
Laura Briley is a person who makes things happen! Not only is she instrumental in creating a new World Forum Working Group for the Rights of Children in Children's Homes, but in April she organized the first ever Pikler Intensive Training in the United States by bringing two internationally famous infant development experts to Tulsa, Oklahoma. In…
A Model for Estimating Nonlinear Deformation and Damage in Ceramic Matrix Composites (Preprint)
2011-07-01
composite along a fiber direction are given by 2 EEE TL1 (A3) 1 TTLL 1 E2 EE (A4) and the longitudinal (L) and transverse (T...properties of a single ply are given by fMffL v1EvEE (A5) ffTfM MfT T v1EvE EE E (A6) L fMMfff L E v1EvE (A7
Smith, Richard H; Hallwirth, Claus V; Westerman, Michael; Hetherington, Nicola A; Tseng, Yu-Shan; Cecchini, Sylvain; Virag, Tamas; Ziegler, Mona-Larissa; Rogozin, Igor B; Koonin, Eugene V; Agbandje-McKenna, Mavis; Kotin, Robert M; Alexander, Ian E
2016-07-05
Germline endogenous viral elements (EVEs) genetically preserve viral nucleotide sequences useful to the study of viral evolution, gene mutation, and the phylogenetic relationships among host organisms. Here, we describe a lineage-specific, adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely related marsupial species. Molecular screening of a marsupial DNA panel indicated that mAAV-EVE1 occurs specifically within the marsupial suborder Macropodiformes (present-day kangaroos, wallabies, and related macropodoids), to the exclusion of other Diprotodontian lineages. Orthologous mAAV-EVE1 locus sequences from sixteen macropodoid species, representing a speciation history spanning an estimated 30 million years, facilitated compilation of an inferred ancestral sequence that recapitulates the genome of an ancient marsupial AAV that circulated among Australian metatherian fauna sometime during the late Eocene to early Oligocene. In silico gene reconstruction and molecular modelling indicate remarkable conservation of viral structure over a geologic timescale. Characterisation of AAV-EVE loci among disparate species affords insight into AAV evolution and, in the case of macropodoid species, may offer an additional genetic basis for assignment of phylogenetic relationships among the Macropodoidea. From an applied perspective, the identified AAV "fossils" provide novel capsid sequences for use in translational research and clinical applications.
Gude, Einar; Gullestad, Lars; Andreassen, Arne K
2017-06-01
De-novo introduction of everolimus (Eve) in heart transplant recipients opens for early reduction of calcineurin inhibitors (CNI) and potential of preserving renal function, attenuate progression of coronary allograft vasculopathy (CAV) and maintain rejection efficacy. The first trials demonstrated adequate rejection prophylaxis and favorable outcomes on CAV, but observed enhanced nephrotoxicity because of insufficient CNI reduction. The SCHEDULE trial compared de-novo Eve with significantly reduced CNI exposure and conversion to CNI-free treatment week 7-11 postheart transplant, with standard CNI immunosuppression. Improved renal function and attenuation of CAV was found among Eve patients, with higher numbers of treated acute rejections observed. With sustained superior renal and CAV related data also after 36 months with the Eve protocol, cardiac function was equally well preserved in both groups. According to the International Society of Heart and Lunge Transplantation registry, mammalian target of rapamycin inhibitor treatment is uncommon during the first postoperative year, with a prevalence of 20% in patients after 5 years. Current evidence suggests a greater benefit from these immunosuppressives if introduced at an earlier timepoint. Immunosuppressive protocols based on Eve treatment in de-novo patients should be further investigated and developed, enabling CNI avoidance before accelerating side-effects lead to irreversible damage.
NASA Astrophysics Data System (ADS)
Buhr, S. M.; McCaffrey, M. S.; Eparvier, F.; Murillo, M.
2008-05-01
Recent immigrant high school students were successfully engaged in learning about Sun-Earth connections through a partnership with the NASA Solar Dynamics Observatory Extreme Ultraviolet Variability Experiment (EVE) project. The students were enrolled in a pilot course as part of the Math, Engineering and Science Achievement (MESA) program. The English Language Learner (ELL) students doubled their achievement on a pre- and post- assessment on the content of the course. Students learned scientific content and vocabulary in English with support in Spanish, attended field trips, hosted scientist speakers, built antenna and deployed space weather monitors as part of the Stanford SOLAR project, and gave final presentations in English, showcasing their new computer skills. Teachers who taught the students in other courses noted gains in the students' willingness to use English in class and noted gains in math skills. The course has been broken into modules for use in shorter after-school environments, or for use by EVE scientists who are outside of the Boulder area. Video footage of "The Making of a Satellite", and "All About EVE" is completed for use in the kits. Other EVE EPO includes upcoming professional development for teachers and content workshops for journalists.
ERIC Educational Resources Information Center
Walker, Julie
2012-01-01
In 2005, a record breaking 26 named tropical storms including 13 hurricanes ravaged the Gulf Coast of the United States. In response to the devastation of hundreds of schools, the Laura Bush Foundation swiftly created The Gulf Coast School Library Recovery Initiative to help school libraries become fully functional and to offer the needed print…
ACT-R/E: An Embodied Cognitive Architecture for Human-Robot Interaction
2013-01-01
Threaded Cognition: An Integrated Theory of Concurrent Multitasking . Psychological Review, 115(1), 101–130, http://dx.doi.org/10.1037/0033-295X...Trafton, Naval Research Laboratory, Washington, DC, USA Email : greg.trafton@nrl.navy.mil Laura Hiatt, Naval Research Laboratory, Washington, DC, USA Email ...laura.hiatt@nrl.navy.mil Anthony Harrison, Naval Research Laboratory, Washington, DC, USA Email : anthony.harrison@nrl.navy.mil Frank Tamborello, Naval
ERIC Educational Resources Information Center
Shatz, Marilyn
1994-01-01
Jeni Yamada's "Laura" and Michael Tomasello's "First Verbs" continue a tradition of providing useful information on the language ability of individuals in a depth rarely found in multisubject studies; however, these efforts are unusual for case studies in that both take strong theoretical positions on the essence of language and language learning.…
Husband, Judith
2013-05-01
Judith Husband speaks to the BDJ about current challenges facing dentistry, the new BDA PEC and her love of social media site Twitter. The only catch is she has accepted the challenge issued by interviewer and fellow Twitter enthusiast Laura Pacey of answering every question, in 140 characters or less. Follow on Twitter @Judith_Husband and @The_BDJ.
Looking outside the (voice)box.
Gartrell, Nanette; Rothblum, Esther
2014-01-01
Laura S. Brown, PhD, is a clinical and forensic psychologist in independent practice in Seattle, Washington. The bulk of her scholarly work has been in the fields of feminist therapy theory, trauma treatment, lesbian and gay issues, assessment and diagnosis, ethics and standards of care in psychotherapy, and cultural competence. She has authored or edited ten professional books, including the award-winning Subversive Dialogues: Theory in Feminist Therapy, as well as more than 140 other professional publications. She has also recently published her first book for general audiences, Your turn for care: Surviving the aging and death of the adults who harmed you. Laura has been featured in five psychotherapy training videos produced by the American Psychological Association. She was President of American Psychological Association Divisions 35 (Society for the Psychology of Women), 44 (Society for the Psychological Study of Lesbian, Gay and Bisexual Issues), and 56 (Trauma Psychology). Laura was also President of the Washington State Psychological Association. She is the founder and Director of the Fremont Community Therapy Project, a low-fee psychotherapy training clinic in Seattle. In the fall of 2000, she was the on-site psychologist for the reality show Survivor: The Australian Outback. In 1987, Laura lost her voice and was diagnosed with spasmodic dysphonia. In 1988, she found her voice again.
NASA Technical Reports Server (NTRS)
Chamberlin, P. C.; Milligan, R. O.; Woods, T. N.
2012-01-01
This paper describes the methods used to obtain the thermal evolution and radiative output during solar flares as observed by the Extreme u ltraviolet Variability Experiment (EVE) onboard the Solar Dynamics Ob servatory (SDO). Presented and discussed in detail are how EVE measur ements, due to its temporal cadence, spectral resolution and spectral range, can be used to determine how the thermal plasma radiates at v arious temperatures throughout the impulsive and gradual phase of fla res. EVE can very accurately determine the radiative output of flares due to pre- and in-flight calibrations. Events are presented that sh ow the total radiated output of flares depends more on the flare duration than the typical GOES X-ray peak magnitude classification. With S DO observing every flare throughout its entire duration and over a la rge temperature range, new insights into flare heating and cooling as well as the radiative energy release in EUV wavelengths support exis ting research into understanding the evolution of solar flares.
The emotional male victim: effects of presentation mode on judged credibility.
Landström, Sara; Ask, Karl; Sommar, Charlotte
2015-02-01
The emotional victim effect (EVE, i.e., that the emotionality of a victim's demeanor affects perceived credibility) is a robust research finding for female victims of rape but much less explored for other types of victims and crimes. In this article, we investigate the EVE with a male assault complainant. In addition, we vary the presentation mode via which the complainant is shown to the assessors. A sample of law students (N = 81) participated in an experiment where they viewed and assessed credibility of a male complainant who appeared either live or on video. The complainant behaved either in an emotional or a neutral manner. Result showed that the presentation mode but not the EVE affected the assessors' credibility assessments: The complainant was perceived as more truthful when communicating live, as opposed to via video. Practical implications, as well as the generality of the EVE, are discussed. © 2014 Scandinavian Psychological Associations and John Wiley & Sons Ltd.
Gariano, John; Neifeld, Mark; Djordjevic, Ivan
2017-01-20
Here, we present the engineering trade studies of a free-space optical communication system operating over a 30 km maritime channel for the months of January and July. The system under study follows the BB84 protocol with the following assumptions: a weak coherent source is used, Eve is performing the intercept resend attack and photon number splitting attack, prior knowledge of Eve's location is known, and Eve is allowed to know a small percentage of the final key. In this system, we examine the effect of changing several parameters in the following areas: the implementation of the BB84 protocol over the public channel, the technology in the receiver, and our assumptions about Eve. For each parameter, we examine how different values impact the secure key rate for a constant brightness. Additionally, we will optimize the brightness of the source for each parameter to study the improvement in the secure key rate.
Achievable Imperative - Baseline Health of the Reserve Component
2001-03-22
Sekikawa, Akira, Ronald E . Laporte , Toshihiko Satoh and Genero Ochi. "Health Workers Need Information From Countries With Better Health Indicators Than...Statistic Quarterly, 48 (1995): 48. 21Thomas E . McKone, Beverly M. Huey, Edward Downing, and Laura M. Duffy, eds., Strategies to Protect the Health of...lmsmr/MSMRTOC.htm>. Internet. Accessed 10 October 2001. McKone, Thomas E ., Beverly M. Huey, Edward Downing, and Laura M. Duffy, eds. Strategies to
The Carolina Autism Transition Study (CATS)
2016-07-20
AWARD NUMBER: W81XWH-15-1-0093 TITLE: The Carolina Autism Transition Study (CATS) PRINCIPAL INVESTIGATOR: Laura Carpenter, MD RECIPIENT...Carolina Autism Transition Study (CATS) 5b. GRANT NUMBER W81XWH-15-1-0093 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) . 5d. PROJECT NUMBER Laura...report provides a description of the Year 1 progress made and plans for Year 2 for the project entitled “The Carolina Autism Transition Study (CATS
ERIC Educational Resources Information Center
Tate, Marsha Ann
2005-01-01
Laura Ingersoll Secord was, admittedly, a well-known historical figure--at least in Canada over a century before the development of the World Wide Web. In 1860, she first achieved widespread notoriety in her adopted homeland of Canada (she was born in Massachusetts) when a deed she performed for the British army during the War of 1812 was publicly…
Assessment of the Air Force Materiel Command Reorganization: Report for Congress
2013-01-01
Report for Congress Don Snyder, Bernard Fox, Kristin F. Lynch, Raymond E. Conley, John A. Ausink, Laura Werber , William Shelton, Sarah A. Nowak, Michael... Bernard Fox, Kristin F. Lynch, Raymond E. Conley, John A. Ausink, Laura Werber , William Shelton, Sarah A. Nowak, Michael R. Thirtle, Albert A. Robbert...Ausink, Chelsea Kaihoi Duran, Robert G. DeFeo, David W. George, Raymond E. Conley, Bernard Fox, and Jerry M. Sollinger, Air Force Materiel Command
Combined LAURA-UPS hypersonic solution procedure
NASA Technical Reports Server (NTRS)
Wood, William A.; Thompson, Richard A.
1993-01-01
A combined solution procedure for hypersonic flowfields around blunted slender bodies was implemented using a thin-layer Navier-Stokes code (LAURA) in the nose region and a parabolized Navier-Stokes code (UPS) on the after body region. Perfect gas, equilibrium air, and non-equilibrium air solutions to sharp cones and a sharp wedge were obtained using UPS alone as a preliminary step. Surface heating rates are presented for two slender bodies with blunted noses, having used LAURA to provide a starting solution to UPS downstream of the sonic line. These are an 8 deg sphere-cone in Mach 5, perfect gas, laminar flow at 0 and 4 deg angles of attack and the Reentry F body at Mach 20, 80,000 ft equilibrium gas conditions for 0 and 0.14 deg angles of attack. The results indicate that this procedure is a timely and accurate method for obtaining aerothermodynamic predictions on slender hypersonic vehicles.
Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes
Suzuki, Yasutsugu; Frangeul, Lionel; Dickson, Laura B.; Blanc, Hervé; Verdier, Yann; Vinh, Joelle
2017-01-01
ABSTRACT Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in Aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. Previous studies identified three EFVEs from Aedes albopictus cell lines and one from Aedes aegypti cell lines. However, an in-depth characterization of EFVEs in wild-type mosquito populations and individual mosquitoes in vivo has not been performed. We detected the full-length DNA sequence of the previously described EFVEs and their respective transcripts in several A. albopictus and A. aegypti populations from geographically distinct areas. However, EFVE-derived proteins were not detected by mass spectrometry. Using deep sequencing, we detected the production of PIWI-interacting RNA-like small RNAs, in an antisense orientation, targeting the EFVEs and their flanking regions in vivo. The EFVEs were integrated in repetitive regions of the mosquito genomes, and their flanking sequences varied among mosquito populations. We bioinformatically predicted several new EFVEs from a Vietnamese A. albopictus population and observed variation in the occurrence of those elements among mosquitoes. Phylogenetic analysis of an A. aegypti EFVE suggested that it integrated prior to the global expansion of the species and subsequently diverged among and within populations. The findings of this study together reveal the substantial structural and nucleotide diversity of flaviviral integrations in Aedes genomes. Unraveling this diversity will help to elucidate the potential biological function of these EFVEs. IMPORTANCE Endogenous viral elements (EVEs) are whole or partial viral sequences integrated in host genomes. Interestingly, some EVEs have important functions for host fitness and antiviral defense. Because mosquitoes also have EVEs in their genomes, characterizing these EVEs is a prerequisite for their potential use to manipulate the mosquito antiviral response. In the study described here, we focused on EVEs related to the Flavivirus genus, to which dengue and Zika viruses belong, in individual Aedes mosquitoes from geographically distinct areas. We show the existence in vivo of flaviviral EVEs previously identified in mosquito cell lines, and we detected new ones. We show that EVEs have evolved differently in each mosquito population. They produce transcripts and small RNAs but not proteins, suggesting a function at the RNA level. Our study uncovers the diverse repertoire of flaviviral EVEs in Aedes mosquito populations and contributes to an understanding of their role in the host antiviral system. PMID:28539440
Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes.
Suzuki, Yasutsugu; Frangeul, Lionel; Dickson, Laura B; Blanc, Hervé; Verdier, Yann; Vinh, Joelle; Lambrechts, Louis; Saleh, Maria-Carla
2017-08-01
Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in Aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. Previous studies identified three EFVEs from Aedes albopictus cell lines and one from Aedes aegypti cell lines. However, an in-depth characterization of EFVEs in wild-type mosquito populations and individual mosquitoes in vivo has not been performed. We detected the full-length DNA sequence of the previously described EFVEs and their respective transcripts in several A. albopictus and A. aegypti populations from geographically distinct areas. However, EFVE-derived proteins were not detected by mass spectrometry. Using deep sequencing, we detected the production of PIWI-interacting RNA-like small RNAs, in an antisense orientation, targeting the EFVEs and their flanking regions in vivo The EFVEs were integrated in repetitive regions of the mosquito genomes, and their flanking sequences varied among mosquito populations. We bioinformatically predicted several new EFVEs from a Vietnamese A. albopictus population and observed variation in the occurrence of those elements among mosquitoes. Phylogenetic analysis of an A. aegypti EFVE suggested that it integrated prior to the global expansion of the species and subsequently diverged among and within populations. The findings of this study together reveal the substantial structural and nucleotide diversity of flaviviral integrations in Aedes genomes. Unraveling this diversity will help to elucidate the potential biological function of these EFVEs. IMPORTANCE Endogenous viral elements (EVEs) are whole or partial viral sequences integrated in host genomes. Interestingly, some EVEs have important functions for host fitness and antiviral defense. Because mosquitoes also have EVEs in their genomes, characterizing these EVEs is a prerequisite for their potential use to manipulate the mosquito antiviral response. In the study described here, we focused on EVEs related to the Flavivirus genus, to which dengue and Zika viruses belong, in individual Aedes mosquitoes from geographically distinct areas. We show the existence in vivo of flaviviral EVEs previously identified in mosquito cell lines, and we detected new ones. We show that EVEs have evolved differently in each mosquito population. They produce transcripts and small RNAs but not proteins, suggesting a function at the RNA level. Our study uncovers the diverse repertoire of flaviviral EVEs in Aedes mosquito populations and contributes to an understanding of their role in the host antiviral system. Copyright © 2017 Suzuki et al.
NASA Astrophysics Data System (ADS)
Buhr, S. M.; Eparvier, F.; McCaffrey, M.; Murillo, M.
2007-12-01
Recent immigrant high school students were successfully engaged in learning about Sun-Earth connections through a partnership with the NASA SDO Extreme-Ultraviolet Variability Experiment (EVE) project. The students were enrolled in a pilot course as part of the Math, Engineering and Science Achievement MESA) program. For many of the students, this was the only science option available to them due to language limitations. The English Language Learner (ELL) students doubled their achievement on a pre- and post-assessment on the content of the course. Students learned scientific content and vocabulary in English with support in Spanish, attended field trips, hosted scientist speakers, built and deployed space weather monitors as part of the Stanford SOLAR project, and gave final presentations in English, showcasing their new computer skills. Teachers who taught the students in other courses noted gains in the students' willingness to use English in class and noted gains in math skills. The MESA-EVE course won recognition as a Colorado MESA Program of Excellence and is being offered again in 2007-08. The course has been broken into modules for use in shorter after-school environments, or for use by EVE scientists who are outside of the Boulder area. Other EVE EPO includes professional development for teachers and content workshops for journalists.
The Carolina Autism Transition Study (CATS)
2017-07-01
AWARD NUMBER: W81XWH-15-1-0093 TITLE: The Carolina Autism Transition Study (CATS) PRINCIPAL INVESTIGATOR: Laura Carpenter, MD RECIPIENT...Carolina Autism Transition Study (CATS) 5b. GRANT NUMBER W81XWH-15-1-0093 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Laura Carpenter...provides a description of the Year 2 progress made and plans for Year 3 for the project entitled “The Carolina Autism Transition Study (CATS).” The goal of
2009-05-04
Fiasco (New York: Penguin Press, 2006), 230. 12 Laura Landes, “ Follow the Money : The Army Finance Corps and Iraqi Financial Independence...Axe, David. “ Follow the Money ; U.S. targets elusive cadre that funds insurgents in Iraq.” Defense Technology International, December 1, 2007...www.army.mil/professionalwriting/ volumes/volume6/december_2008/12_08_3 _pf.html (accessed March 23, 2009). Landes, Laura. “ Follow the Money : The
NASA Technical Reports Server (NTRS)
Edquist, Karl T.
2006-01-01
Comparisons are made between the LAURA Navier-Stokes code and Viking Lander Capsule hypersonic aerodynamics data from ground and flight measurements. Wind tunnel data are available for a 3.48 percent scale model at Mach 6 and a 2.75 percent scale model at Mach 10.35, both under perfect gas air conditions. Viking Lander 1 aerodynamics flight data also exist from on-board instrumentation for velocities between 2900 and 4400 m/sec (Mach 14 to 23.3). LAURA flowfield solutions are obtained for the geometry as tested or flown, including sting effects at tunnel conditions and finite-rate chemistry effects in flight. Using the flight vehicle center-of-gravity location (trim angle approx. equals -11.1 deg), the computed trim angle at tunnel conditions is within 0.31 degrees of the angle derived from Mach 6 data and 0.13 degrees from the Mach 10.35 trim angle. LAURA Mach 6 trim lift and drag force coefficients are within 2 percent of measured data, and computed trim lift-to-drag ratio is within 4 percent of the data. Computed trim lift and drag force coefficients at Mach 10.35 are within 5 percent and 3 percent, respectively, of wind tunnel data. Computed trim lift-to-drag ratio is within 2 percent of the Mach 10.35 data. Using the nominal density profile and center-of-gravity location, LAURA trim angle at flight conditions is within 0.5 degrees of the total angle measured from on-board instrumentation. LAURA trim lift and drag force coefficients at flight conditions are within 7 and 5 percent, respectively, of the flight data. Computed trim lift-to-drag ratio is within 4 percent of the data. Computed aerodynamics sensitivities to center-of-gravity location, atmospheric density, and grid refinement are generally small. The results will enable a better estimate of aerodynamics uncertainties for future Mars entry vehicles where non-zero angle-of-attack is required.
Eye Movements Behavior While Driving a Car: A Review
1978-10-01
should be filtered if only the relevant information input is to be inveatigated. -13- The analysis of eye movements bahavior should be consi- dered... volunt rvtlv switch hi , attent on From one eve to the other (e.q. LACK, 19"’). The accomodation of the eve at a greater distance in car Jriving
Satan's Temptation of Eve in "Paradise Lost": A Rhetorical Analysis.
ERIC Educational Resources Information Center
Ward, Dee Ann Duke
John Milton employs classical rhetorical techniques in "Paradise Lost" to accomplish Satan's temptation of Eve which begins on line 524 and ends with line 732 of Book 9; however, Satan's oration resembles pejorative sophistry and Milton uses Ciceronian arrangement for Satan's argument. Milton envisions Satan as a clever, cunning creature…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-01
... Determinations: ``Wtewael's Adam and Eve'' SUMMARY: Notice is hereby given of the following determinations... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Wtewael's Adam and Eve,'' imported from abroad for temporary exhibition within the United States, is of cultural...
Overview of Key Results from SDO Extreme ultraviolet Variability Experiment (EVE)
NASA Astrophysics Data System (ADS)
Woods, Tom; Eparvier, Frank; Jones, Andrew; Mason, James; Didkovsky, Leonid; Chamberlin, Phil
2016-10-01
The SDO Extreme ultraviolet Variability Experiment (EVE) includes several channels to observe the solar extreme ultraviolet (EUV) spectral irradiance from 1 to 106 nm. These channels include the Multiple EUV Grating Spectrograph (MEGS) A, B, and P channels from the University of Colorado (CU) and the EUV SpectroPhometer (ESP) channels from the University of Southern California (USC). The solar EUV spectrum is rich in many different emission lines from the corona, transition region, and chromosphere. The EVE full-disk irradiance spectra are important for studying the solar impacts in Earth's ionosphere and thermosphere and are useful for space weather operations. In addition, the EVE observations, with its high spectral resolution of 0.1 nm and in collaboration with AIA solar EUV images, have proven valuable for studying active region evolution and explosive energy release during flares and coronal eruptions. These SDO measurements have revealed interesting results such as understanding the flare variability over all wavelengths, discovering and classifying different flare phases, using coronal dimming measurements to predict CME properties of mass and velocity, and exploring the role of nano-flares in continual heating of active regions.
Implementation of a Blowing Boundary Condition in the LAURA Code
NASA Technical Reports Server (NTRS)
Thompson, Richard a.; Gnoffo, Peter A.
2008-01-01
Preliminary steps toward modeling a coupled ablation problem using a finite-volume Navier-Stokes code (LAURA) are presented in this paper. Implementation of a surface boundary condition with mass transfer (blowing) is described followed by verification and validation through comparisons with analytic results and experimental data. Application of the code to a carbon-nosetip ablation problem is demonstrated and the results are compared with previously published data. It is concluded that the code and coupled procedure are suitable to support further ablation analyses and studies.
Utari, Heny Budi; Soowannayan, Chumporn; Flegel, Timothy W; Whityachumnarnkul, Boonsirm; Kruatrachue, Maleeya
2017-11-01
The viral accommodation hypothesis proposes that endogenous viral elements (EVE) from both RNA and DNA viruses are being continually integrated into the shrimp genome by natural host processes and that they can result in tolerance to viral infection by fortuitous production of antisense, immunospecific RNA (imRNA). Thus, we hypothesized that previously reported microarray results for the presence of white spot syndrome virus (WSSV) open reading frames (ORFs) formerly called 151, 366 and 427 in a domesticated giant tiger shrimp (Penaeus monodon) breeding stock might have represented expression from EVE, since the stock had shown uninterrupted freedom from white spot disease (WSD) for many generations. To test this hypothesis, 128 specimens from a current stock generation were confirmed for freedom from WSSV infection using two nested PCR detection methods. Subsequent nested-PCR testing revealed 33/128 specimens (26%) positive for at least one of the ORF at very high sequence identity (95-99%) to extant WSSV. Positive results for ORF 366 (now known to be a fragment of the WSSV capsid protein gene) dominated (28/33 = 84.8%), so 9 arbitrarily selected 366-positive specimens were tested by strand-specific, nested RT-PCR using DNase-treated RNA templates. This revealed variable RNA expression in individual shrimp including no RNA transcripts (n = 1), sense transcripts only (n = 1), antisense transcripts only (n = 2) or transcripts of both sense (n = 5). The latter 7 expression products indicated specimens producing putative imRNA. The variable types and numbers of the EVE and the variable RNA expression (including potential imRNA) support predictions of the viral accommodation hypothesis that EVE are randomly produced and expressed. Positive nested PCR test results for EVE of ORF 366 using DNA templates derived from shrimp sperm (germ cells), indicated that they were heritable. Copyright © 2017 Elsevier Ltd. All rights reserved.
Noguchi, Shinzaburo; Masuda, Norikazu; Iwata, Hiroji; Mukai, Hirofumi; Horiguchi, Jun; Puttawibul, Puttisak; Srimuninnimit, Vichien; Tokuda, Yutaka; Kuroi, Katsumasa; Iwase, Hirotaka; Inaji, Hideo; Ohsumi, Shozo; Noh, Woo-Chul; Nakayama, Takahiro; Ohno, Shinji; Rai, Yoshiaki; Park, Byeong-Woo; Panneerselvam, Ashok; El-Hashimy, Mona; Taran, Tetiana; Sahmoud, Tarek; Ito, Yoshinori
2014-11-01
The addition of mTOR inhibitor everolimus (EVE) to exemestane (EXE) was evaluated in an international, phase 3 study (BOLERO-2) in patients with hormone-receptor-positive (HR(+)) breast cancer refractory to letrozole or anastrozole. The safety and efficacy of anticancer treatments may be influenced by ethnicity (Sekine et al. in Br J Cancer 99:1757-62, 2008). Safety and efficacy results from Asian versus non-Asian patients in BOLERO-2 are reported. Patients were randomized (2:1) to 10 mg/day EVE + EXE or placebo (PBO) + EXE. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival, response rate, clinical benefit rate, and safety. Of 143 Asian patients, 98 received EVE + EXE and 45 received PBO + EXE. Treatment with EVE + EXE significantly improved median PFS versus PBO + EXE among Asian patients by 38 % (HR = 0.62; 95 % CI, 0.41-0.94). Median PFS was also improved among non-Asian patients by 59 % (HR = 0.41; 95 % CI, 0.33-0.50). Median PFS duration among EVE-treated Asian patients was 8.48 versus 4.14 months for PBO + EXE, and 7.33 versus 2.83 months, respectively, in non-Asian patients. The most common grade 3/4 adverse events (stomatitis, anemia, elevated liver enzymes, hyperglycemia, and dyspnea) occurred at similar frequencies in Asian and non-Asian patients. Grade 1/2 interstitial lung disease occurred more frequently in Asian patients. Quality of life was similar between treatment arms in Asian patients. Adding EVE to EXE provided substantial clinical benefit in both Asian and non-Asian patients with similar safety profiles. This combination represents an improvement in the management of postmenopausal women with HR(+)/HER2(-) advanced breast cancer progressing on nonsteroidal aromatase inhibitors, regardless of ethnicity.
Aerodynamic Database Development for Mars Smart Lander Vehicle Configurations
NASA Technical Reports Server (NTRS)
Bobskill, Glenn J.; Parikh, Paresh C.; Prabhu, Ramadas K.; Tyler, Erik D.
2002-01-01
An aerodynamic database has been generated for the Mars Smart Lander Shelf-All configuration using computational fluid dynamics (CFD) simulations. Three different CFD codes, USM3D and FELISA, based on unstructured grid technology and LAURA, an established and validated structured CFD code, were used. As part of this database development, the results for the Mars continuum were validated with experimental data and comparisons made where applicable. The validation of USM3D and LAURA with the Unitary experimental data, the use of intermediate LAURA check analyses, as well as the validation of FELISA with the Mach 6 CF(sub 4) experimental data provided a higher confidence in the ability for CFD to provide aerodynamic data in order to determine the static trim characteristics for longitudinal stability. The analyses of the noncontinuum regime showed the existence of multiple trim angles of attack that can be unstable or stable trim points. This information is needed to design guidance controller throughout the trajectory.
The Right to Control One's Own Body: A Look at the "Eve" Decision.
ERIC Educational Resources Information Center
Rioux, Marcia; Yarmol, Karen
1987-01-01
The article reviews the arguments and decision of the "Eve" sterilization case decided by the Supreme Court of Canada. The court held that no one, including the courts themselves, has the power to approve the sterilization, for contraceptive purposes, of any person, mentally handicapped or not, who does not give consent. (DB)
ERIC Educational Resources Information Center
Zuiker, Steven J.
2012-01-01
As a global cyberinfrastructure, the Internet makes authentic digital problem spaces like educational virtual environments (EVEs) available to a wide range of classrooms, schools and education systems operating under different circumstantial, practical, social and cultural conditions. And yet, if the makers and users of EVEs both have a hand in…
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-20
...-AA00 Safety Zone; City of Beaufort's Tricentennial New Year's Eve Fireworks Display, Beaufort River... establishing a temporary safety zone on the Beaufort River, in Beaufort, South Carolina, during the City of... Carolina. The fireworks will be launched from a barge, which will be located on the Beaufort River. The...
Employing Virtual Humans for Education and Training in X3D/VRML Worlds
ERIC Educational Resources Information Center
Ieronutti, Lucio; Chittaro, Luca
2007-01-01
Web-based education and training provides a new paradigm for imparting knowledge; students can access the learning material anytime by operating remotely from any location. Web3D open standards, such as X3D and VRML, support Web-based delivery of Educational Virtual Environments (EVEs). EVEs have a great potential for learning and training…
Williams, Kevin; Bilsland, Elizabeth; Sparkes, Andrew; Aubrey, Wayne; Young, Michael; Soldatova, Larisa N; De Grave, Kurt; Ramon, Jan; de Clare, Michaela; Sirawaraporn, Worachart; Oliver, Stephen G; King, Ross D
2015-03-06
There is an urgent need to make drug discovery cheaper and faster. This will enable the development of treatments for diseases currently neglected for economic reasons, such as tropical and orphan diseases, and generally increase the supply of new drugs. Here, we report the Robot Scientist 'Eve' designed to make drug discovery more economical. A Robot Scientist is a laboratory automation system that uses artificial intelligence (AI) techniques to discover scientific knowledge through cycles of experimentation. Eve integrates and automates library-screening, hit-confirmation, and lead generation through cycles of quantitative structure activity relationship learning and testing. Using econometric modelling we demonstrate that the use of AI to select compounds economically outperforms standard drug screening. For further efficiency Eve uses a standardized form of assay to compute Boolean functions of compound properties. These assays can be quickly and cheaply engineered using synthetic biology, enabling more targets to be assayed for a given budget. Eve has repositioned several drugs against specific targets in parasites that cause tropical diseases. One validated discovery is that the anti-cancer compound TNP-470 is a potent inhibitor of dihydrofolate reductase from the malaria-causing parasite Plasmodium vivax.
NASA Astrophysics Data System (ADS)
Eparvier, F. G.; McCaffrey, M. S.; Buhr, S. M.
2008-12-01
With the aim of meeting NASA goals for education and public outreach as well as support education reform efforts including the National Science Education Standards, a suite of education materials and strategies have been developed by the Cooperative Institute for Environmental Sciences (CIRES) with the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado for the Extreme Ultraviolet Variability Experiment (EVE), which is an instrument aboard the Solar Dynamic Observatory. This paper will examine the education materials that have been developed for teachers in the classroom and scientists who are conducting outreach, including handouts, a website on space weather for teachers, a slideshow presentation about the overall Solar Dynamic Observatory mission, and a DVD with videos explaining the construction and goals of the EVE instrument, a tour of LASP, and an overview of space science careers. The results and potential transferability of a pilot project developed through this effort that engaged English Second Language learners in a semester-long course on space weather that incorporated the used of a Sudden Ionospheric Disturbance (SID) Monitor will be highlighted.
Structural genomics reveals EVE as a new ASCH/PUA-related domain
Bertonati, Claudia; Punta, Marco; Fischer, Markus; Yachdav, Guy; Forouhar, Farhad; Zhou, Weihong; Kuzin, Alexander P.; Seetharaman, Jayaraman; Abashidze, Mariam; Ramelot, Theresa A.; Kennedy, Michael A.; Cort, John R.; Belachew, Adam; Hunt, John F.; Tong, Liang; Montelione, Gaetano T.; Rost, Burkhard
2014-01-01
Summary We report on several proteins recently solved by structural genomics consortia, in particular by the Northeast Structural Genomics consortium (NESG). The proteins considered in this study differ substantially in their sequences but they share a similar structural core, characterized by a pseudobarrel five-stranded beta sheet. This core corresponds to the PUA domain-like architecture in the SCOP database. By connecting sequence information with structural knowledge, we characterize a new subgroup of these proteins that we propose to be distinctly different from previously described PUA domain-like domains such as PUA proper or ASCH. We refer to these newly defined domains as EVE. Although EVE may have retained the ability of PUA domains to bind RNA, the available experimental and computational data suggests that both the details of its molecular function and its cellular function differ from those of other PUA domain-like domains. This study of EVE and its relatives illustrates how the combination of structure and genomics creates new insights by connecting a cornucopia of structures that map to the same evolutionary potential. Primary sequence information alone would have not been sufficient to reveal these evolutionary links. PMID:19191354
Structural Genomics Reveals EVE as a New ASCH/PUA-Related Domain
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bertonati, C.; Punta, M; Fischer, M
2008-01-01
We report on several proteins recently solved by structural genomics consortia, in particular by the Northeast Structural Genomics consortium (NESG). The proteins considered in this study differ substantially in their sequences but they share a similar structural core, characterized by a pseudobarrel five-stranded beta sheet. This core corresponds to the PUA domain-like architecture in the SCOP database. By connecting sequence information with structural knowledge, we characterize a new subgroup of these proteins that we propose to be distinctly different from previously described PUA domain-like domains such as PUA proper or ASCH. We refer to these newly defined domains as EVE.more » Although EVE may have retained the ability of PUA domains to bind RNA, the available experimental and computational data suggests that both the details of its molecular function and its cellular function differ from those of other PUA domain-like domains. This study of EVE and its relatives illustrates how the combination of structure and genomics creates new insights by connecting a cornucopia of structures that map to the same evolutionary potential. Primary sequence information alone would have not been sufficient to reveal these evolutionary links.« less
Characteristics of the Shuttle Orbiter Leeside Flow During A Reentry Condition
NASA Technical Reports Server (NTRS)
Kleb, William L.; Weilmuenster, K. James
1992-01-01
A study of the leeside flow characteristics of the Shuttle Orbiter is presented for a reentry flight condition. The flow is computed using a point-implicit, finite-volume scheme known as the Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA). LAURA is a second-order accurate, laminar Navier-Stokes solver, incorporating finite-rate chemistry with a radiative equilibrium wall temperature distribution and finite-rate wall catalysis. The resulting computational solution is analyzed in terms of salient flow features and the surface quantities are compared with flight data.
ERIC Educational Resources Information Center
Barokka (Okka), Khairani
2017-01-01
This article presents lessons from touring a show on pain with limited resources and in chronic pain. In 2014, I toured solo deaf-accessible poetry/art show "Eve and Mary Are Having Coffee" in various forms in the UK, Austria, and India. As an Indonesian woman with then-extreme chronic pain and fatigue, herein are lessons learned from…
NASA Astrophysics Data System (ADS)
Chatterjee, Krishnendu; Horn, Florian; Löding, Christof
Graph games of infinite length provide a natural model for open reactive systems: one player (Eve) represents the controller and the other player (Adam) represents the environment. The evolution of the system depends on the decisions of both players. The specification for the system is usually given as an ω-regular language L over paths and Eve's goal is to ensure that the play belongs to L irrespective of Adam's behaviour.
Lim, Issel Anne L; Faria, Andreia V; Li, Xu; Hsu, Johnny T C; Airan, Raag D; Mori, Susumu; van Zijl, Peter C M
2013-11-15
The purpose of this paper is to extend the single-subject Eve atlas from Johns Hopkins University, which currently contains diffusion tensor and T1-weighted anatomical maps, by including contrast based on quantitative susceptibility mapping. The new atlas combines a "deep gray matter parcellation map" (DGMPM) derived from a single-subject quantitative susceptibility map with the previously established "white matter parcellation map" (WMPM) from the same subject's T1-weighted and diffusion tensor imaging data into an MNI coordinate map named the "Everything Parcellation Map in Eve Space," also known as the "EvePM." It allows automated segmentation of gray matter and white matter structures. Quantitative susceptibility maps from five healthy male volunteers (30 to 33 years of age) were coregistered to the Eve Atlas with AIR and Large Deformation Diffeomorphic Metric Mapping (LDDMM), and the transformation matrices were applied to the EvePM to produce automated parcellation in subject space. Parcellation accuracy was measured with a kappa analysis for the left and right structures of six deep gray matter regions. For multi-orientation QSM images, the Kappa statistic was 0.85 between automated and manual segmentation, with the inter-rater reproducibility Kappa being 0.89 for the human raters, suggesting "almost perfect" agreement between all segmentation methods. Segmentation seemed slightly more difficult for human raters on single-orientation QSM images, with the Kappa statistic being 0.88 between automated and manual segmentation, and 0.85 and 0.86 between human raters. Overall, this atlas provides a time-efficient tool for automated coregistration and segmentation of quantitative susceptibility data to analyze many regions of interest. These data were used to establish a baseline for normal magnetic susceptibility measurements for over 60 brain structures of 30- to 33-year-old males. Correlating the average susceptibility with age-based iron concentrations in gray matter structures measured by Hallgren and Sourander (1958) allowed interpolation of the average iron concentration of several deep gray matter regions delineated in the EvePM. Copyright © 2013 Elsevier Inc. All rights reserved.
Lim, Issel Anne L.; Faria, Andreia V.; Li, Xu; Hsu, Johnny T.C.; Airan, Raag D.; Mori, Susumu; van Zijl, Peter C. M.
2013-01-01
The purpose of this paper is to extend the single-subject Eve atlas from Johns Hopkins University, which currently contains diffusion tensor and T1-weighted anatomical maps, by including contrast based on quantitative susceptibility mapping. The new atlas combines a “deep gray matter parcellation map” (DGMPM) derived from a single-subject quantitative susceptibility map with the previously established “white matter parcellation map” (WMPM) from the same subject’s T1-weighted and diffusion tensor imaging data into an MNI coordinate map named the “Everything Parcellation Map in Eve Space,” also known as the “EvePM.” It allows automated segmentation of gray matter and white matter structures. Quantitative susceptibility maps from five healthy male volunteers (30 to 33 years of age) were coregistered to the Eve Atlas with AIR and Large Deformation Diffeomorphic Metric Mapping (LDDMM), and the transformation matrices were applied to the EvePM to produce automated parcellation in subject space. Parcellation accuracy was measured with a kappa analysis for the left and right structures of six deep gray matter regions. For multi-orientation QSM images, the Kappa statistic was 0.85 between automated and manual segmentation, with the inter-rater reproducibility Kappa being 0.89 for the human raters, suggesting “almost perfect” agreement between all segmentation methods. Segmentation seemed slightly more difficult for human raters on single-orientation QSM images, with the Kappa statistic being 0.88 between automated and manual segmentation, and 0.85 and 0.86 between human raters. Overall, this atlas provides a time-efficient tool for automated coregistration and segmentation of quantitative susceptibility data to analyze many regions of interest. These data were used to establish a baseline for normal magnetic susceptibility measurements for over 60 brain structures of 30- to 33-year-old males. Correlating the average susceptibility with age-based iron concentrations in gray matter structures measured by Hallgren and Sourander (1958) allowed interpolation of the average iron concentration of several deep gray matter regions delineated in the EvePM. PMID:23769915
Ground-water resources of the Laura area, Majuro Atoll, Marshall Islands
Hamlin, S.N.; Anthony, S.S.
1987-01-01
The water system that supplies the heavily populated Dalap-Uliga-Darrit (DUD) area of Majuro atoll, Marshall Island, relies almost entirely upon airstrip catchment of rain water. Droughts cause severe water supply problems and water rationing is required, even during periods of normal rainfall. The Laura area contains a substantial lens of fresh groundwater that could be developed for export to the DUD area 30 mi to the east. Study of the groundwater resource at Laura involved a survey of existing wells, installation of monitoring wells and test holes, compilation of continuous records of rainfall and water level fluctuations, and collection of water quality data. Test hole data permitted the definition of three geohydrologic units which correlate well with similar units in Bikini and Enewetak atolls. The units consist of two layers of unconsolidated reef and lagoon sediments resting on a dense, highly permeable limestone. The potable water zone, or freshwater nucleus, of the lens is contained mostly within the unconsolidated layers, which are much less permeable than the basal limestone. Recharge to the Laura freshwater lens is estimated to be 1.8 mil gal/day, based on an average annual rainfall of 140 in. Sustainable yield is estimated to be about 400,000 gal/day. Shallow skimming wells or infiltration galleries similar to those used on Kwajalein atoll would be appropriate to develop the freshwater lens. The impact of development on the lens can be determined by monitoring the salinity in developed water and in a network of monitor wells. (Author 's abstract)
Foot strike pattern in children during shod-unshod running.
Latorre Román, Pedro Ángel; Balboa, Fernando Redondo; Pinillos, Felipe García
2017-10-01
The purpose of this study was to determine the foot strike patterns (FSPs) and neutral support (no INV/EVE and no foot rotation) in children, as well as to determine the influence of shod/unshod conditions and sex. A total of 713 children, aged 6 to 16 years, participated in this study (Age=10.28±2.71years, body mass index [BMI]=19.70±3.91kg/m 2 , 302 girls and 411 boys). A sagittal and frontal-plane video (240Hz) was recorded using a high-speed camcorder, to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/eversion (INV/EVE) and foot rotation on initial contact. RFS prevalence was similar between boys and girls in both shod and unshod conditions. In the unshod condition there was a significant reduction (p<0.001) of RFS prevalence both in boys (shod condition=83.95% vs. 62.65% unshod condition) and in girls (shod condition=87.85% vs. 62.70% unshod condition). No significant differences were found in INV/EVE and foot rotation between sex groups. In the unshod condition there was a significant increase (p<0.001) of neutral support (no INV/EVE) both in boys (shod condition=12.55% vs. 22.22% unshod condition) and in girls (shod condition=17.9% vs. 28.15% unshod condition). In addition, in the unshod condition there is a significant reduction (p<0.001) of neutral support (no foot rotation) both in boys (shod condition=21.55% vs. 11.10% unshod condition) and in girls (shod condition=21.05% vs. 11.95% unshod condition). In children, RFS prevalence is lower than adult's population. Additionally, barefoot running reduced the prevalence of RFS and INV/EVE, however increased foot rotation. Copyright © 2017 Elsevier B.V. All rights reserved.
Song, Yang; Wan, Xiaoming; Bai, Shuoxin; Guo, Dong; Ren, Ci; Zeng, Yu; Li, Yirui; Li, Xuewen
2017-01-01
Background The elevation and dissipation of pollutants after the ignition of fireworks in different functional areas of a valley city were investigated. Methods The Air Quality Index (AQI) as well as inter-day and intra-day concentrations of various air pollutants (PM10, PM2.5, SO2, NO2, CO, O3) were measured during two episodes that took place during Chinese New Year festivities. Results For the special terrain of Jinan, the mean concentrations of pollutants increased sharply within 2–4 h of the firework displays, and concentrations were 4–6 times higher than the usual levels. It took 2–3 d for the pollutants to dissipate to background levels. Compared to Preliminary Eve (more fireworks are ignited on New Year’s Eve, but the amounts of other human activities are also lesser), the primary pollutants PM2.5, PM10, and CO reached higher concentrations on New Year’s Eve, and the highest concentrations of these pollutants were detected in living quarters. All areas suffered from serious pollution problems on New Year’s Eve (rural = urban for PM10, but rural > urban for PM2.5). However, SO2 and NO2 levels were 20%–60% lower in living quarters and industrial areas compared to the levels in these same areas on Preliminary Eve. In contrast to the other pollutants, O3 concentrations fell instead of rising with the firework displays. Conclusion Interactions between firework displays and other human activities caused different change trends of pollutants. PM2.5 and PM10 were the main pollutants, and the rural living quarter had some of the highest pollution levels. PMID:28045925
Alinia, Siros; Rezaei, Satar; Daroudi, Rajabali; Hadadi, Mashyaneh; Akbari Sari, Ali
2013-01-01
Abstract: Background: Fireworks are commonly used in local and national celebrations. The aim of this study is to explore the extent, nature and hospital costs of injuries related to the Persian Wednesday Eve festival in Iran. Methods: Data for injuries caused by fireworks during the 2009 Persian Wednesday Eve festival were collected from the national Ministry of Health database. Injuries were divided into nine groups and the average and total hospital costs were estimated for each group. The cost of care for patients with burns was estimated by reviewing a sample of 100 patients randomly selected from a large burn center in Tehran. Other costs were estimated by conducting semi structured interviews with expert managers at two large government hospitals. Results: 1817 people were injured by fireworks during the 2009 Wednesday Eve festival. The most frequently injured sites were the hand (43.3%), eye (24.5%) and face (13.2%), and the most common types of injury were burns (39.9%), contusions/abrasions (24.6%) and lacerations (12.7%). The mean length of hospital stay was 8.15 days for patients with burns, 10.7 days for those with amputations, and 3 days for those with other types of injury. The total hospital cost of injuries was US$ 284 000 and the average cost per injury was US$ 156. The total hospital cost of patients with amputations was US$ 48 598. Most of the costs were related to burns (56.6%) followed by amputations (12.2%). Conclusions: Injuries related to the Persian Wednesday Eve festival are common and lead to extensive morbidity and medical costs. PMID:21964162
Alinia, Siros; Rezaei, Satar; Daroudi, Rajabali; Hadadi, Mashyaneh; Akbari Sari, Ali
2013-01-01
Fireworks are commonly used in local and national celebrations. The aim of this study is to explore the extent, nature and hospital costs of injuries related to the Persian Wednesday Eve festival in Iran. Data for injuries caused by fireworks during the 2009 Persian Wednesday Eve festival were collected from the national Ministry of Health database. Injuries were divided into nine groups and the average and total hospital costs were estimated for each group. The cost of care for patients with burns was estimated by reviewing a sample of 100 patients randomly selected from a large burn center in Tehran. Other costs were estimated by conducting semi structured interviews with expert managers at two large government hospitals. 1817 people were injured by fireworks during the 2009 Wednesday Eve festival. The most frequently injured sites were the hand (43.3%), eye (24.5%) and face (13.2%), and the most common types of injury were burns (39.9%), contusions/abrasions (24.6%) and lacerations (12.7%). The mean length of hospital stay was 8.15 days for patients with burns, 10.7 days for those with amputations, and 3 days for those with other types of injury. The total hospital cost of injuries was US$ 284 000 and the average cost per injury was US$ 156. The total hospital cost of patients with amputations was US$ 48 598. Most of the costs were related to burns (56.6%) followed by amputations (12.2%). Injuries related to the Persian Wednesday Eve festival are common and lead to extensive morbidity and medical costs. © 2013 KUMS, All rights reserved.
Song, Yang; Wan, Xiaoming; Bai, Shuoxin; Guo, Dong; Ren, Ci; Zeng, Yu; Li, Yirui; Li, Xuewen
2017-01-01
The elevation and dissipation of pollutants after the ignition of fireworks in different functional areas of a valley city were investigated. The Air Quality Index (AQI) as well as inter-day and intra-day concentrations of various air pollutants (PM10, PM2.5, SO2, NO2, CO, O3) were measured during two episodes that took place during Chinese New Year festivities. For the special terrain of Jinan, the mean concentrations of pollutants increased sharply within 2-4 h of the firework displays, and concentrations were 4-6 times higher than the usual levels. It took 2-3 d for the pollutants to dissipate to background levels. Compared to Preliminary Eve (more fireworks are ignited on New Year's Eve, but the amounts of other human activities are also lesser), the primary pollutants PM2.5, PM10, and CO reached higher concentrations on New Year's Eve, and the highest concentrations of these pollutants were detected in living quarters. All areas suffered from serious pollution problems on New Year's Eve (rural = urban for PM10, but rural > urban for PM2.5). However, SO2 and NO2 levels were 20%-60% lower in living quarters and industrial areas compared to the levels in these same areas on Preliminary Eve. In contrast to the other pollutants, O3 concentrations fell instead of rising with the firework displays. Interactions between firework displays and other human activities caused different change trends of pollutants. PM2.5 and PM10 were the main pollutants, and the rural living quarter had some of the highest pollution levels.
OBSERVATIONS OF ENHANCED EXTREME ULTRAVIOLET CONTINUA DURING AN X-CLASS SOLAR FLARE USING SDO/EVE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Milligan, Ryan O.; Mathioudakis, Mihalis; Keenan, Francis P.
2012-03-20
Observations of extreme ultraviolet (EUV) emission from an X-class solar flare that occurred on 2011 February 15 at 01:44 UT are presented, obtained using the EUV Variability Experiment (EVE) on board the Solar Dynamics Observatory. The complete EVE spectral range covers the free-bound continua of H I (Lyman continuum), He I, and He II, with recombination edges at 91.2, 50.4, and 22.8 nm, respectively. By fitting the wavelength ranges blueward of each recombination edge with an exponential function, light curves of each of the integrated continua were generated over the course of the flare, as was emission from the free-freemore » continuum (6.5-37 nm). The He II 30.4 nm and Ly{alpha} 121.6 nm lines, and soft X-ray (SXR; 0.1-0.8 nm) emission from GOES are also included for comparison. Each free-bound continuum was found to have a rapid rise phase at the flare onset similar to that seen in the 25-50 keV light curves from RHESSI, suggesting that they were formed by recombination with free electrons in the chromosphere. However, the free-free emission exhibited a slower rise phase seen also in the SXR emission from GOES, implying a predominantly coronal origin. By integrating over the entire flare the total energy emitted via each process was determined. We find that the flare energy in the EVE spectral range amounts to at most a few percent of the total flare energy, but EVE gives us a first comprehensive look at these diagnostically important continuum components.« less
Solar flare impulsive phase emission observed with SDO/EVE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kennedy, Michael B.; Milligan, Ryan O.; Mathioudakis, Mihalis
2013-12-10
Differential emission measures (DEMs) during the impulsive phase of solar flares were constructed using observations from the EUV Variability Experiment (EVE) and the Markov-Chain Monte Carlo method. Emission lines from ions formed over the temperature range log T{sub e} = 5.8-7.2 allow the evolution of the DEM to be studied over a wide temperature range at 10 s cadence. The technique was applied to several M- and X-class flares, where impulsive phase EUV emission is observable in the disk-integrated EVE spectra from emission lines formed up to 3-4 MK and we use spatially unresolved EVE observations to infer the thermalmore » structure of the emitting region. For the nine events studied, the DEMs exhibited a two-component distribution during the impulsive phase, a low-temperature component with peak temperature of 1-2 MK, and a broad high-temperature component from 7 to 30 MK. A bimodal high-temperature component is also found for several events, with peaks at 8 and 25 MK during the impulsive phase. The origin of the emission was verified using Atmospheric Imaging Assembly images to be the flare ribbons and footpoints, indicating that the constructed DEMs represent the spatially average thermal structure of the chromospheric flare emission during the impulsive phase.« less
CONSTRAINING SOLAR FLARE DIFFERENTIAL EMISSION MEASURES WITH EVE AND RHESSI
DOE Office of Scientific and Technical Information (OSTI.GOV)
Caspi, Amir; McTiernan, James M.; Warren, Harry P.
2014-06-20
Deriving a well-constrained differential emission measure (DEM) distribution for solar flares has historically been difficult, primarily because no single instrument is sensitive to the full range of coronal temperatures observed in flares, from ≲2 to ≳50 MK. We present a new technique, combining extreme ultraviolet (EUV) spectra from the EUV Variability Experiment (EVE) onboard the Solar Dynamics Observatory with X-ray spectra from the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI), to derive, for the first time, a self-consistent, well-constrained DEM for jointly observed solar flares. EVE is sensitive to ∼2-25 MK thermal plasma emission, and RHESSI to ≳10 MK; together, the twomore » instruments cover the full range of flare coronal plasma temperatures. We have validated the new technique on artificial test data, and apply it to two X-class flares from solar cycle 24 to determine the flare DEM and its temporal evolution; the constraints on the thermal emission derived from the EVE data also constrain the low energy cutoff of the non-thermal electrons, a crucial parameter for flare energetics. The DEM analysis can also be used to predict the soft X-ray flux in the poorly observed ∼0.4-5 nm range, with important applications for geospace science.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Niederberger, Armand; Scarani, Valerio; Gisin, Nicolas
2005-04-01
In practical quantum cryptography, the source sometimes produces multiphoton pulses, thus enabling the eavesdropper Eve to perform the powerful photon-number-splitting (PNS) attack. Recently, it was shown by Curty and Luetkenhaus [Phys. Rev. A 69, 042321 (2004)] that the PNS attack is not always the optimal attack when two photons are present: if errors are present in the correlations Alice-Bob and if Eve cannot modify Bob's detection efficiency, Eve gains a larger amount of information using another attack based on a 2{yields}3 cloning machine. In this work, we extend this analysis to all distances Alice-Bob. We identify a new incoherent 2{yields}3more » cloning attack which performs better than those described before. Using it, we confirm that, in the presence of errors, Eve's better strategy uses 2{yields}3 cloning attacks instead of the PNS. However, this improvement is very small for the implementations of the Bennett-Brassard 1984 (BB84) protocol. Thus, the existence of these new attacks is conceptually interesting but basically does not change the value of the security parameters of BB84. The main results are valid both for Poissonian and sub-Poissonian sources.« less
Distributed-Memory Computing With the Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA)
NASA Technical Reports Server (NTRS)
Riley, Christopher J.; Cheatwood, F. McNeil
1997-01-01
The Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA), a Navier-Stokes solver, has been modified for use in a parallel, distributed-memory environment using the Message-Passing Interface (MPI) standard. A standard domain decomposition strategy is used in which the computational domain is divided into subdomains with each subdomain assigned to a processor. Performance is examined on dedicated parallel machines and a network of desktop workstations. The effect of domain decomposition and frequency of boundary updates on performance and convergence is also examined for several realistic configurations and conditions typical of large-scale computational fluid dynamic analysis.
ERIC Educational Resources Information Center
Thurmond, Gloria J.
2007-01-01
The Church's interpretation of the current ecological crisis as a moral crisis is the catalyst for this essay, which proposes a newly constructed faith-based model for ecological dialogue and education. The exploration and reinterpretation of the traditional Church doctrine of the Virgin Mary as the new Eve provides a theme from which an…
The Origin of the EUV Late Phase: A Case Study of the C8.8 Flare on 2010 May 5
NASA Technical Reports Server (NTRS)
Hock, R. A.; Woods, T. N.; Klimchuk, J. A.; Eparvier, F. G.; Jones, A. R.
2012-01-01
Since the launch of NASA's Solar Dynamics Observatory on 2010 February 11, the Extreme ultraviolet Variability Experiment (EVE) has observed numerous flares. One interesting feature observed by EVE is that a subset of flares exhibit an additional enhancement of the 2-3 million K emission several hours after the flares soft X-ray emission. From the Atmospheric Imaging Assembly (AIA) images, we observe that this secondary emission, dubbed the EUV late phase, occurs in the same active region as the flare but not in the same coronal loops. Here, we examine the C8.8 flare that occurred on 2010 May 5 as a case study of EUV late phase flares. In addition to presenting detailed observations from both AIA and EVE, we develop a physical model of this flare and test it using the Enthalpy Based Thermal Evolution of Loops (EBTEL) model.
No-signaling quantum key distribution: solution by linear programming
NASA Astrophysics Data System (ADS)
Hwang, Won-Young; Bae, Joonwoo; Killoran, Nathan
2015-02-01
We outline a straightforward approach for obtaining a secret key rate using only no-signaling constraints and linear programming. Assuming an individual attack, we consider all possible joint probabilities. Initially, we study only the case where Eve has binary outcomes, and we impose constraints due to the no-signaling principle and given measurement outcomes. Within the remaining space of joint probabilities, by using linear programming, we get bound on the probability of Eve correctly guessing Bob's bit. We then make use of an inequality that relates this guessing probability to the mutual information between Bob and a more general Eve, who is not binary-restricted. Putting our computed bound together with the Csiszár-Körner formula, we obtain a positive key generation rate. The optimal value of this rate agrees with known results, but was calculated in a more straightforward way, offering the potential of generalization to different scenarios.
TALE-mediated modulation of transcriptional enhancers in vivo.
Crocker, Justin; Stern, David L
2013-08-01
We tested whether transcription activator-like effectors (TALEs) could mediate repression and activation of endogenous enhancers in the Drosophila genome. TALE repressors (TALERs) targeting each of the five even-skipped (eve) stripe enhancers generated repression specifically of the focal stripes. TALE activators (TALEAs) targeting the eve promoter or enhancers caused increased expression primarily in cells normally activated by the promoter or targeted enhancer, respectively. This effect supports the view that repression acts in a dominant fashion on transcriptional activators and that the activity state of an enhancer influences TALE binding or the ability of the VP16 domain to enhance transcription. In these assays, the Hairy repression domain did not exhibit previously described long-range transcriptional repression activity. The phenotypic effects of TALER and TALEA expression in larvae and adults are consistent with the observed modulations of eve expression. TALEs thus provide a novel tool for detection and functional modulation of transcriptional enhancers in their native genomic context.
Functional Equivalence Acceptance Testing of FUN3D for Entry Descent and Landing Applications
NASA Technical Reports Server (NTRS)
Gnoffo, Peter A.; Wood, William A.; Kleb, William L.; Alter, Stephen J.; Glass, Christopher E.; Padilla, Jose F.; Hammond, Dana P.; White, Jeffery A.
2013-01-01
The functional equivalence of the unstructured grid code FUN3D to the the structured grid code LAURA (Langley Aerothermodynamic Upwind Relaxation Algorithm) is documented for applications of interest to the Entry, Descent, and Landing (EDL) community. Examples from an existing suite of regression tests are used to demonstrate the functional equivalence, encompassing various thermochemical models and vehicle configurations. Algorithm modifications required for the node-based unstructured grid code (FUN3D) to reproduce functionality of the cell-centered structured code (LAURA) are also documented. Challenges associated with computation on tetrahedral grids versus computation on structured-grid derived hexahedral systems are discussed.
Fault Tolerance in Critical Information Systems
2001-05-01
that provides an inte- grated editing and analysis environment through the use of the Adobe FrameMaker document processor [1] and the Z/Eves theorem... FrameMaker document processor provid- ing the special character set for Z just as it would any other character set (such as mathe- matical symbols). Zeus...happens to use the LaTeX Z language definition, so Zeus processes the Framemaker spec- ification and outputs the LaTeX translation to Z/Eves for
Potential Links between Hepadnavirus and Bornavirus Sequences in the Host Genome and Cancer.
Honda, Tomoyuki
2017-01-01
Various viruses leave their sequences in the host genomes during infection. Such events occur mainly in retrovirus infection but also sometimes in DNA and non-retroviral RNA virus infections. If viral sequences are integrated into the genomes of germ line cells, the sequences can become inherited as endogenous viral elements (EVEs). The integration events of viral sequences may have oncogenic potential. Because proviral integrations of some retroviruses and/or reactivation of endogenous retroviruses are closely linked to cancers, viral insertions related to non-retroviral viruses also possibly contribute to cancer development. This article focuses on genomic viral sequences derived from two non-retroviral viruses, whose endogenization is already reported, and discusses their possible contributions to cancer. Viral insertions of hepatitis B virus play roles in the development of hepatocellular carcinoma. Endogenous bornavirus-like elements, the only non-retroviral RNA virus-related EVEs found in the human genome, may also be involved in cancer formation. In addition, the possible contribution of the interactions between viruses and retrotransposons, which seem to be a major driving force for generating EVEs related to non-retroviral RNA viruses, to cancers will be discussed. Future studies regarding the possible links described here may open a new avenue for the development of novel therapeutics for tumor virus-related cancers and/or provide novel insights into EVE functions.
NASA Astrophysics Data System (ADS)
Su, Guoshao; Shi, Yanjiong; Feng, Xiating; Jiang, Jianqing; Zhang, Jie; Jiang, Quan
2018-02-01
Rockbursts are markedly characterized by the ejection of rock fragments from host rocks at certain speeds. The rockburst process is always accompanied by acoustic signals that include acoustic emissions (AE) and sounds. A deep insight into the evolutionary features of AE and sound signals is important to improve the accuracy of rockburst prediction. To investigate the evolutionary features of AE and sound signals, rockburst tests on granite rock specimens under true-triaxial loading conditions were performed using an improved rockburst testing system, and the AE and sounds during rockburst development were recorded and analyzed. The results show that the evolutionary features of the AE and sound signals were obvious and similar. On the eve of a rockburst, a `quiescent period' could be observed in both the evolutionary process of the AE hits and the sound waveform. Furthermore, the time-dependent fractal dimensions of the AE hits and sound amplitude both showed a tendency to continuously decrease on the eve of the rockbursts. In addition, on the eve of the rockbursts, the main frequency of the AE and sound signals both showed decreasing trends, and the frequency spectrum distributions were both characterized by low amplitudes, wide frequency bands and multiple peak shapes. Thus, the evolutionary features of sound signals on the eve of rockbursts, as well as that of AE signals, can be used as beneficial information for rockburst prediction.
The EVE Doppler Sensitivity and Flare Observations
NASA Technical Reports Server (NTRS)
Hudson, H. S.; Woods, T. N.; Chamberlin, P. C.; Didkovsky, L.; Del Zanna, G.
2011-01-01
The Extreme-ultraviolet Variability Experiment (EVE) obtains continuous EUV spectra of the Sun viewed as a star. Its primary objective is the characterization of solar spectral irradiance, but its sensitivity and stability make it extremely interesting for observations of variability on time scales down to the limit imposed by its basic 10 s sample interval. In this paper we characterize the Doppler sensitivity of the EVE data. We find that the 30.4 nm line of He II has a random Doppler error below 0.001 nm (1 pm, better than 10 km/s as a redshift), with ample stability to detect the orbital motion of its satellite, the Solar Dynamics Observatory (SDO). Solar flares also displace the spectrum, both because of Doppler shifts and because of EVE's optical layout, which (as with a slitless spectrograph) confuses position and wavelength. As a flare develops, the centroid of the line displays variations that reflect Doppler shifts and therefore flare dynamics. For the impulsive phase of the flare SOL2010-06-12, we find the line centroid to have a redshift of 16.8 +/- 5.9 km/s relative to that of the flare gradual phase (statistical errors only). We find also that high-temperature lines, such as Fe XXIV 19.2 nm, have well-determined Doppler components for major flares, with decreasing apparent blueshifts as expected from chromospheric evaporation flows.
CPAP Devices for Emergency Prehospital Use: A Bench Study.
Brusasco, Claudia; Corradi, Francesco; De Ferrari, Alessandra; Ball, Lorenzo; Kacmarek, Robert M; Pelosi, Paolo
2015-12-01
CPAP is frequently used in prehospital and emergency settings. An air-flow output minimum of 60 L/min and a constant positive pressure are 2 important features for a successful CPAP device. Unlike hospital CPAP devices, which require electricity, CPAP devices for ambulance use need only an oxygen source to function. The aim of the study was to evaluate and compare on a bench model the performance of 3 orofacial mask devices (Ventumask, EasyVent, and Boussignac CPAP system) and 2 helmets (Ventukit and EVE Coulisse) used to apply CPAP in the prehospital setting. A static test evaluated air-flow output, positive pressure applied, and FIO2 delivered by each device. A dynamic test assessed airway pressure stability during simulated ventilation. Efficiency of devices was compared based on oxygen flow needed to generate a minimum air flow of 60 L/min at each CPAP setting. The EasyVent and EVE Coulisse devices delivered significantly higher mean air-flow outputs compared with the Ventumask and Ventukit under all CPAP conditions tested. The Boussignac CPAP system never reached an air-flow output of 60 L/min. The EasyVent had significantly lower pressure excursion than the Ventumask at all CPAP levels, and the EVE Coulisse had lower pressure excursion than the Ventukit at 5, 15, and 20 cm H2O, whereas at 10 cm H2O, no significant difference was observed between the 2 devices. Estimated oxygen consumption was lower for the EasyVent and EVE Coulisse compared with the Ventumask and Ventukit. Air-flow output, pressure applied, FIO2 delivered, device oxygen consumption, and ability to maintain air flow at 60 L/min differed significantly among the CPAP devices tested. Only the EasyVent and EVE Coulisse achieved the required minimum level of air-flow output needed to ensure an effective therapy under all CPAP conditions. Copyright © 2015 by Daedalus Enterprises.
Kourlaba, Georgia; Rapti, Vasiliki; Alexopoulos, Athanasios; Relakis, John; Koumakis, Georgios; Chatzikou, Magdalini; Maniadakis, Nikos; Georgoulias, Vassilis
2015-08-05
The objective of our study was to conduct a cost-effectiveness (CE) study of combined everolimus (EVE) and exemestane (EXE) versus the common clinical practice in Greece for the treatment of postmenopausal women with HR+/HER2- advanced breast cancer (BC) progressing on nonsteroidal aromatase inhibitors (NSAI). The combinations of bevacizumab (BEV) plus paclitaxel (PACL) and BEV plus capecitabine (CAPE) were selected as comparators. A Markov model, consisting of three health states, was used to describe disease progression and evaluate the CE of the comparators from a third-party payer perspective over a lifetime horizon. Efficacy and safety data as well as utility values considered in the model were extracted from the relevant randomized Phase III clinical trials and other published studies. Direct medical costs referring to the year 2014 were incorporated in the model. A probabilistic sensitivity analysis was conducted to account for uncertainty and variation in the parameters of the model. Primary outcomes were patient survival (life-years), quality-adjusted life years (QALYs), total direct costs and incremental cost-effectiveness ratios (ICER). The discounted quality-adjusted survival of patients treated with EVE plus EXE was greater by 0.035 and 0.004 QALYs, compared to BEV plus PACL and BEV plus CAPE, respectively. EVE plus EXE was the least costly treatment in terms of drug acquisition, administration, and concomitant medications. The total lifetime cost per patient was estimated at €55,022, €67,980, and €62,822 for EVE plus EXE, BEV plus PACL, and BEV plus CAPE, respectively. The probabilistic analysis confirmed the deterministic results. Our results suggest that EVE plus EXE may be a dominant alternative relative to BEV plus PACL and BEV plus CAPE for the treatment of HR+/HER2- advanced BC patients failing initial therapy with NSAIs.
Mizutani, Miho Yamada; Itai, Akiko
2004-09-23
A method of easily finding ligands, with a variety of core structures, for a given target macromolecule would greatly contribute to the rapid identification of novel lead compounds for drug development. We have developed an efficient method for discovering ligand candidates from a number of flexible compounds included in databases, when the three-dimensional (3D) structure of the drug target is available. The method, named ADAM&EVE, makes use of our automated docking method ADAM, which has already been reported. Like ADAM, ADAM&EVE takes account of the flexibility of each molecule in databases, by exploring the conformational space fully and continuously. Database screening has been made much faster than with ADAM through the tuning of parameters, so that computational screening of several hundred thousand compounds is possible in a practical time. Promising ligand candidates can be selected according to various criteria based on the docking results and characteristics of compounds. Furthermore, we have developed a new tool, EVE-MAKE, for automatically preparing the additional compound data necessary for flexible docking calculation, prior to 3D database screening. Among several successful cases of lead discovery by ADAM&EVE, the finding of novel acetylcholinesterase (AChE) inhibitors is presented here. We performed a virtual screening of about 160 000 commercially available compounds against the X-ray crystallographic structure of AChE. Among 114 compounds that could be purchased and assayed, 35 molecules with various core structures showed inhibitory activities with IC(50) values less than 100 microM. Thirteen compounds had IC(50) values between 0.5 and 10 microM, and almost all their core structures are very different from those of known inhibitors. The results demonstrate the effectiveness and validity of the ADAM&EVE approach and provide a starting point for development of novel drugs to treat Alzheimer's disease.
Enceladus Environmental Explorer (EVE): A Mission Concept
NASA Astrophysics Data System (ADS)
Lawson, M. J.; Amador, E. S.; Carrier, B. L.; Albuja, A.; Bapst, J.; Cahill, K. R. S.; Ebersohn, F.; Gainey, S.; Gartrelle, G.; Greenberger, R. N.; Hale, J. M.; Johnston, S.; Olivares, J.; Parcheta, C. E.; Sheehan, J. P.; Thorpe, A. K.; Zareh, S. K.
2014-12-01
Enceladus is an intriguing planetary body, which possibly has the ingredients needed for life. Further, it has numerous (over 100) continuously erupting geysers that eject material into the atmosphere which provide a unique opportunity to sample the body's internal chemistry from orbit. At JPL's Planetary Science Summer School, Team X and a group of students developed a mission concept to directly sample Enceladus' plumes. The mission, named Enceladus Environmental Explorer (EVE), follows NASA's Planetary Science Decadal survey and would assess the potential habitability of Saturn's icy satellite through analysis of the chemistry of the subsurface ocean and the nature of the organic chemistry in the plume. EVE would look at geological and geophysical surface processes of Enceladus by investigating the heat output of Enceladus, plumes' mechanics, the extent of the liquid subsurface reservoir(s), and gravitational variation. The EVE mission concept aimed for a January 2023 launch on an Atlas 551 class launch vehicle and would arrive at Saturn July 2031. A two-year-long Saturn moon tour would allow sufficient deceleration to permit a polar orbital insertion around Enceladus in March 2035, remaining stable for 54 weeks of observation. The proposed instrument payload includes: 1) SUb MilliMeter Enceladus Radiometer (SUMMER; equivalent to Rosetta MIRO), 2) Enceladus Dust and Gas Experiment (EDGE; an enhanced version of Rosetta COSIMA), 3) MAGnetometer for Ionic Concentration (MAGIC; equivalent to MMS/ InSIGHT magnetometer), 4) Visual Imaging Camera with Topographic Observational Resolution (VICTOR) and 5) Enceladus Radio Gravity Science (ERGS). Our suggested orbital timeline would allow the most comprehensive dataset yet collected of a moon in the outer solar system, mapping the entire surface twice with SUMMER and VICTOR, while sampling the plume directly 232 times with EDGE. MAGIC would also provide over a year of sampling of the magnetic field variations from orbit. Enceladus Environmental Explorer (EVE) offers a unique opportunity to determine the potential for life on Enceladus.
Limits on negative information in language input.
Morgan, J L; Travis, L L
1989-10-01
Hirsh-Pasek, Treiman & Schneiderman (1984) and Demetras, Post & Snow (1986) have recently suggested that certain types of parental repetitions and clarification questions may provide children with subtle cues to their grammatical errors. We further investigated this possibility by examining parental responses to inflectional over-regularizations and wh-question auxiliary-verb omission errors in the sets of transcripts from Adam, Eve and Sarah (Brown 1973). These errors were chosen because they are exemplars of overgeneralization, the type of mistake for which negative information is, in theory, most critically needed. Expansions and Clarification Questions occurred more often following ill-formed utterances in Adam's and Eve's input, but not in Sarah's. However, these corrective responses formed only a small proportion of all adult responses following Adam's and Eve's grammatical errors. Moreover, corrective responses appear to drop out of children's input while they continue to make overgeneralization errors. Whereas negative feedback may occasionally be available, in the light of these findings the contention that language input generally incorporates negative information appears to be unfounded.
Countering the Non-State Nuclear Threat: Are We Ready?
2005-01-01
Problem……………………………………… 7 B. Civilian Nuclear Sources………….………………………………… 10 C. The “ Brain Drain” ………………………………………………….. 13 V. US POLICY ON NUCLEAR...4 Jay Ackerman and Laura Snyder. “Would They if They Could?” Bulletin of the Atomic Scientists, Vol. 58, no. 3...New York: Columbia University Press, 1998), 94. 6 Jay Ackerman and Laura Snyder. “Would They if They Could?” Bulletin of the Atomic Scientists, Vol. 58
Shelepov, A M; Ishutin, O S; Leonik, S I
2011-06-01
This article evaluates military and political situation in the world and operational-strategic environment on the West Theater of operations on the eve of the Great Patriotic War (1941-1945). We analyze structure and overall condition of sanitary service of West Special Military District of the Workers and Peasants Red Army and causes of failure of mobilization, organization and deployment of military units and establishments from the beginning of aggression of Fascist Germany to the Soviet Union.
... Syncope. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice ... by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine ...
NASA Astrophysics Data System (ADS)
Sojka, Jan J.; Jensen, Joseph B.; David, Michael; Schunk, Robert W.; Woods, Tom; Eparvier, Frank; Sulzer, Michael P.; Gonzalez, Sixto A.; Eccles, J. Vincent
2014-05-01
This study evaluates how the new irradiance observations from the NASA Solar Dynamics Observatory (SDO) Extreme Ultraviolet Variability Experiment (EVE) can, with its high spectral resolution and 10 s cadence, improve the modeling of the E region. To demonstrate this a campaign combining EVE observations with that of the NSF Arecibo incoherent scatter radar (ISR) was conducted. The ISR provides E region electron density observations with high-altitude resolution, 300 m, and absolute densities using the plasma line technique. Two independent ionospheric models were used, the Utah State University Time-Dependent Ionospheric Model (TDIM) and Space Environment Corporation's Data-Driven D Region (DDDR) model. Each used the same EVE irradiance spectrum binned at 1 nm resolution from 0.1 to 106 nm. At the E region peak the modeled TDIM density is 20% lower and that of the DDDR is 6% higher than observed. These differences could correspond to a 36% lower (TDIM) and 12% higher (DDDR) production rate if the differences were entirely attributed to the solar irradiance source. The detailed profile shapes that included the E region altitude and that of the valley region were only qualitatively similar to observations. Differences on the order of a neutral-scale height were present. Neither model captured a distinct dawn to dusk tilt in the E region peak altitude. A model sensitivity study demonstrated how future improved spectral resolution of the 0.1 to 7 nm irradiance could account for some of these model shortcomings although other relevant processes are also poorly modeled.
The Adam and Eve story as exemplar of an early-life variant of the oedipus complex.
Osman, M P
2000-01-01
The Adam and Eve story is construed as having an organizing function that facilitates the analytic understanding of certain patients. In this interpretation, the story epitomizes a psychodynamic in which progressive growth, with separation and individuation, of the young is experienced as perilous--not only to them, but also correspondingly to their procreators. In the myth, the increasing psychic and physical maturation of Adam and Eve produced a crisis. Not only was divine authority flouted, but also apprehensions were aroused that God might be humbled or diminished. This threatened him, evoking his wrath and leading to the punishment by abandonment of his youthful wards. It is suggested that the story depicts an emotional complex of widespread application and is an archaic version of the oedipus complex, continuous with the oedipus complex proper, but from an earlier stage of development. This archaic complex is delineated with clinical vignettes, and a clinical explication of its various components is provided. Clinical management is considered, particularly with reference to the challenge that a closed-system perspective (Fairbairn 1958) presents to a patient's development.
A Design Problem of Assembly Line Systems using Genetic Algorithm under the BTO Environment
NASA Astrophysics Data System (ADS)
Abe, Kazuaki; Yamada, Tetsuo; Matsui, Masayuki
Under the BTO environment, stochastic assembly lines require design methods which shorten not only the production lead time but also the ready time for the line design. We propose a design method for Assembly Line Systems (ALS) in Yamada et al. (2001) by using Genetic Algorithm (GA) and Adam-Eve GA, in which all design variables are determined in consideration of constraints such as line length related to the production lead time. First, an ALS model with a line length constraint is introduced, and an optimal design problem is set to maximize the net reward under shorter lead time. Next, a simulation optimization method is developed using Adam-Eve GA and traditional GA. Finally, an optimal design example is shown and discussed by comparing the 2-stage design by Yamada et al. (2001) and both the GA designs. It is shown that the Adam-Eve GA is superior to the traditional GA design in terms of computational time though there is only a slight difference in terms of net reward.
OBSERVATIONS OF THERMAL FLARE PLASMA WITH THE EUV VARIABILITY EXPERIMENT
DOE Office of Scientific and Technical Information (OSTI.GOV)
Warren, Harry P.; Doschek, George A.; Mariska, John T.
2013-06-20
One of the defining characteristics of a solar flare is the impulsive formation of very high temperature plasma. The properties of the thermal emission are not well understood, however, and the analysis of solar flare observations is often predicated on the assumption that the flare plasma is isothermal. The EUV Variability Experiment (EVE) on the Solar Dynamics Observatory provides spectrally resolved observations of emission lines that span a wide range of temperatures (e.g., Fe XV-Fe XXIV) and allow for thermal flare plasma to be studied in detail. In this paper we describe a method for computing the differential emission measuremore » distribution in a flare using EVE observations and apply it to several representative events. We find that in all phases of the flare the differential emission measure distribution is broad. Comparisons of EVE spectra with calculations based on parameters derived from the Geostationary Operational Environmental Satellites soft X-ray fluxes indicate that the isothermal approximation is generally a poor representation of the thermal structure of a flare.« less
Upconversion-based receivers for quantum hacking-resistant quantum key distribution
NASA Astrophysics Data System (ADS)
Jain, Nitin; Kanter, Gregory S.
2016-07-01
We propose a novel upconversion (sum frequency generation)-based quantum-optical system design that can be employed as a receiver (Bob) in practical quantum key distribution systems. The pump governing the upconversion process is produced and utilized inside the physical receiver, making its access or control unrealistic for an external adversary (Eve). This pump facilitates several properties which permit Bob to define and control the modes that can participate in the quantum measurement. Furthermore, by manipulating and monitoring the characteristics of the pump pulses, Bob can detect a wide range of quantum hacking attacks launched by Eve.
The Science of Change: The Importance of Methodology in Leading Change in the Army
2007-05-24
the institution. The scope of these changes is unprecedented and the potential for “organizational whiplash ” is extremely high. Therefore, the...D eve lop s tra teg ies fo r ach iev ing tha t v is ion 4 . C o m m u n ic a te th e ch an g e v is io n • U se eve ry veh ic le poss...right people across the stratum of the organization for the team, and avoiding including only the ‘usual suspects’ such as departmental heads
Kakafika, Anna I; Athyros, Vasilios G; Tziomalos, Konstantinos; Karagiannis, Asterios; Mikhailidis, Dimitri P
2008-06-01
Women differ from men in terms of their cardiovascular disease risk. The existing data suggest that primary cardiovascular disease prevention treatment with a statin could be cost effective for women and men with a high cardiovascular disease risk. In secondary cardiovascular disease prevention both men and women seem to benefit equally from statin treatment. However, the relatively small number of women included in several statin trials has limited the evidence available. With regard to the question of whether Eve is becoming Adam, the answer is not yet: we need more evidence!
... Direct bilirubin - urine Images Male urinary system References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...
Heavy metals in the bottom sediments of the Furo of Laura estuary, Eastern Amazon, Brazil.
Lima, M W; Santos, M L S; Faial, K C F; Freitas, E S; Lima, M O; Pereira, J A R; Cunha, I P R T
2017-05-15
The Furo of Laura is an economically important river in the Amazon estuary. Thus, in the present study, we evaluated the metal distribution (Al, Cd, Co, Cu, Cr, Fe, Ni, and Mg) in the bottom sediments of this river. The sediments were sampled at four points every 2months for a year with an Ekman-Birge sampler. After microwave acid digestion, the metal levels were determined by optical emission spectrometry with inductively coupled plasma. The particle size and organic matter content influenced the concentration of the metals. The sediments were not enriched by the analyzed metals; the estuary therefore retained the characteristics of an uncontaminated environment, thus serving as a reference environment for comparison. Copyright © 2017 Elsevier Ltd. All rights reserved.
[Age discrimination. Point of view of the professionals].
Ribera Casado, Jose Manuel; Bustillos, Antonio; Guerra Vaquero, Ana Ilenia; Huici Casal, Carmen; Fernández-Ballesteros, Rocío
2016-01-01
It is generally believed that legislation is an essential resource in the prevention of discriminatory behaviour against older people. This study first examines the Spanish legislation for potential age discrimination and then uses the C-EVE-D questionnaire to ask professionals in social work and health care settings the extent to what certain ageist behaviours described in the questionnaire are observed in practice. The field study was carried out with professionals in geriatrics and gerontology, who are members of Spanish Society for Geriatrics and Gerontology (SEGG). The EVE discrimination questionnaire consists of 28 items which investigate the existence of age discrimination in medical and social care contexts. A total of 174 people (63% women; mean age: 45.6 years) took part in the study, with a mean professional experience of 17.2 years. Doctors made up 59% of the sample, psychologists 19%, with the rest coming from other professions. The first 20 discrimination items of the EVE-D questionnaire were significantly positively reported by more than 60% of the sample. Although Spanish legislation, from the constitution down to the rules that govern social and health care settings, clearly prohibits any kind of discrimination with regard to age, our results show that Spanish professionals most closely involved in the care of older people perceive both direct and indirect age discrimination. Furthermore, evidence was found of prejudice in the treatment of older people as a phenomenon in day-to-day health and social services care, both when analysing medical cases and, to a greater extent, cases of a more general nature and/or relating to co-existence. Copyright © 2016 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.
2013-01-01
Background Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Methods Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Results Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Conclusion Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings. PMID:24028542
Earnest, Arul; Chen, Mark I C; Seow, Eillyne
2006-01-22
It has been postulated that patients admitted on weekends or after office hours may experience delays in clinical management and consequently have longer length of stay (LOS). We investigated if day and time of admission is associated with LOS in Tan Tock Seng Hospital (TTSH), a 1,400 bed acute care tertiary hospital serving the central and northern regions of Singapore. This was a historical cohort study based on all admissions from TTSH from 1st September 2003 to 31st August 2004. Data was extracted from routinely available computerized hospital information systems for analysis by episode of care. LOS for each episode of care was log-transformed before analysis, and a multivariate linear regression model was used to study if sex, age group, type of admission, admission source, day of week admitted, admission on a public holiday or eve of public holiday, admission on a weekend and admission time were associated with an increased LOS. In the multivariate analysis, sex, age group, type of admission, source of admission, admission on the eve of public holiday and weekends and time of day admitted were independently and significantly associated with LOS. Patients admitted on Friday, Saturday or Sunday stayed on average 0.3 days longer than those admitted on weekdays, after adjusting for potential confounders; those admitted on the eve of public holidays, and those admitted in the afternoons and after office hours also had a longer LOS (differences of 0.71, 1.14 and 0.65 days respectively). Cases admitted over a weekend, eve of holiday, in the afternoons, and after office hours, do have an increased LOS. Further research is needed to identify processes contributing to the above phenomenon.
Massebo, Fekadu; Lindtjørn, Bernt
2013-09-12
Screening of houses might have impact on density of indoor host-seeking Anopheles mosquitoes. A randomized trial of screening windows and doors with metal mesh, and closing openings on eves and walls by mud was conducted to assess if reduce indoor densities of biting mosquitoes. Mosquitoes were collected in forty houses using Centers for Diseases Control and Prevention (CDC) light traps biweekly in March and April 2011. A randomization of houses into control and intervention groups was done based on the baseline data. Windows and doors of 20 houses were screened by metal mesh, and openings on the walls and eves closed by mud and the rest 20 houses were used as control group. Mosquitoes were collected biweekly in October and November 2011 from both control and intervention houses. A Generalized Estimating Equations (GEE) with a negative binomial error distribution was used to account for over dispersion of Anopheles arabiensis and culicine counts and repeated catches made in the same house. Screening doors and windows, and closing openings on eves and wall by mud reduced the overall indoor densities of An. arabiensis by 40%. The effect of screenings pronounced on unfed An. arabiensis by resulting 42% reduction in houses with interventions. The total costs for screening windows and doors, and to close openings on the eves and walls by mud was 7.34 USD per house. Screening houses reduced indoor density of An. arabiensis, and it was cheap and can easily incorporated into malaria vector strategies by local communities, but improving doors and windows fitness for screening should be considered during house construction to increase the efficacy of screenings.
... Renal cell carcinoma Alternative Names Alkaline phosphatase References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...
... Alkaline phosphatase isoenzyme test Images Blood test References Berk PD, Korenblat KM. Approach to the patient with ... Review Date 5/21/2017 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...
dynamics. She has performed research in sustainable mobility, network optimization, supply chain analysis Experience Supply Chain Design Consultant, LLamasoft, Ann Arbor, MI Featured Publications Laura J
Argonne Physics Division Colloquium
and the birth of gravitational wave astronomy Host: Seamus Riordan 11 May 2018 18 May 2018 Laura University of Illinois at Chicago Physics Department Colloquia Northwestern University Physics and Astronomy
... courtesy of Laura King Benjamin King, star of Disney Channel's hit TV series Liv and Maddie , helps ... root in so many homes that watch the Disney Channel and have children—especially considering the number ...
Functional domains of the Drosophila Engrailed protein.
Han, K; Manley, J L
1993-01-01
We have studied the transcriptional activity of the Drosophila homeodomain protein Engrailed (En) by using a transient expression assay employing Schneider L2 cells. En was found to very strongly repress promoters activated by a variety of different activator proteins. However, unlike another Drosophila homeodomain-containing repressor, Even-skipped (Eve), En was unable to repress the activity of several basal promoters in the absence of activator expression. These findings indicate that En is a specific repressor of activated transcription, and suggest that En may repress transcription by a different mechanism than Eve, perhaps by interfering with interactions between transcriptional activators and the general transcription machinery. By analyzing the properties of a variety of En mutants, we identified a minimal repression domain composed of 55 residues, which can function when fused to a heterologous DNA binding domain. Like repression domains identified in the Drosophila repressors Eve and Krüppel, the En repression domain is rich in alanine residues (26%), but unlike these other domains, is moderately charged (six arginine and three glutamic acid residues). Separate regions of En that may in some circumstances function in transcriptional activation were also identified. Images PMID:8334991
Stochastic model for gene transcription on Drosophila melanogaster embryos
NASA Astrophysics Data System (ADS)
Prata, Guilherme N.; Hornos, José Eduardo M.; Ramos, Alexandre F.
2016-02-01
We examine immunostaining experimental data for the formation of stripe 2 of even-skipped (eve) transcripts on D. melanogaster embryos. An estimate of the factor converting immunofluorescence intensity units into molecular numbers is given. The analysis of the eve dynamics at the region of stripe 2 suggests that the promoter site of the gene has two distinct regimes: an earlier phase when it is predominantly activated until a critical time when it becomes mainly repressed. That suggests proposing a stochastic binary model for gene transcription on D. melanogaster embryos. Our model has two random variables: the transcripts number and the state of the source of mRNAs given as active or repressed. We are able to reproduce available experimental data for the average number of transcripts. An analysis of the random fluctuations on the number of eves and their consequences on the spatial precision of stripe 2 is presented. We show that the position of the anterior or posterior borders fluctuate around their average position by ˜1 % of the embryo length, which is similar to what is found experimentally. The fitting of data by such a simple model suggests that it can be useful to understand the functions of randomness during developmental processes.
Williams, Kevin; Bilsland, Elizabeth; Sparkes, Andrew; Aubrey, Wayne; Young, Michael; Soldatova, Larisa N.; De Grave, Kurt; Ramon, Jan; de Clare, Michaela; Sirawaraporn, Worachart; Oliver, Stephen G.; King, Ross D.
2015-01-01
There is an urgent need to make drug discovery cheaper and faster. This will enable the development of treatments for diseases currently neglected for economic reasons, such as tropical and orphan diseases, and generally increase the supply of new drugs. Here, we report the Robot Scientist ‘Eve’ designed to make drug discovery more economical. A Robot Scientist is a laboratory automation system that uses artificial intelligence (AI) techniques to discover scientific knowledge through cycles of experimentation. Eve integrates and automates library-screening, hit-confirmation, and lead generation through cycles of quantitative structure activity relationship learning and testing. Using econometric modelling we demonstrate that the use of AI to select compounds economically outperforms standard drug screening. For further efficiency Eve uses a standardized form of assay to compute Boolean functions of compound properties. These assays can be quickly and cheaply engineered using synthetic biology, enabling more targets to be assayed for a given budget. Eve has repositioned several drugs against specific targets in parasites that cause tropical diseases. One validated discovery is that the anti-cancer compound TNP-470 is a potent inhibitor of dihydrofolate reductase from the malaria-causing parasite Plasmodium vivax. PMID:25652463
Passive Faraday-mirror attack in a practical two-way quantum-key-distribution system
NASA Astrophysics Data System (ADS)
Sun, Shi-Hai; Jiang, Mu-Sheng; Liang, Lin-Mei
2011-06-01
The Faraday mirror (FM) plays a very important role in maintaining the stability of two-way plug-and-play quantum key distribution (QKD) systems. However, the practical FM is imperfect, which will not only introduce an additional quantum bit error rate (QBER) but also leave a loophole for Eve to spy the secret key. In this paper we propose a passive Faraday mirror attack in two-way QKD system based on the imperfection of FM. Our analysis shows that if the FM is imperfect, the dimension of Hilbert space spanned by the four states sent by Alice is three instead of two. Thus Eve can distinguish these states with a set of Positive Operator Valued Measure (POVM) operators belonging to three-dimension space, which will reduce the QBER induced by her attack. Furthermore, a relationship between the degree of the imperfection of FM and the transmittance of the practical QKD system is obtained. The results show that the probability that Eve loads her attack successfully depends on the degree of the imperfection of FM rapidly, but the QBER induced by Eve’s attack changes slightly with the degree of the FM imperfection.
Panganiban, Ronald A; Sun, Maoyun; Dahlin, Amber; Park, Hae-Ryung; Kan, Mengyuan; Himes, Blanca E; Mitchel, Jennifer A; Iribarren, Carlos; Jorgenson, Eric; Randell, Scott H; Israel, Elliot; Tantisira, Kelan; Shore, Stephanie; Park, Jin-Ah; Weiss, Scott T; Wu, Ann Chen; Lu, Quan
2018-01-09
Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the associated variants to a function that could influence asthma, and as a result, the identity of the asthma gene(s) remains elusive. We sought to identify and characterize functional variants in the 17q21 locus. We used the Exome Aggregation Consortium browser to identify coding (amino acid-changing) variants in the 17q21 locus. We obtained asthma association measures for these variants in both the Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort (16,274 cases and 38,269 matched controls) and the EVE Consortium study (5,303 asthma cases and 12,560 individuals). Gene expression and protein localization were determined by quantitative RT-PCR and fluorescence immunostaining, respectively. Molecular and cellular studies were performed to determine the functional effects of coding variants. Two coding variants (rs2305480 and rs11078928) of the gasdermin B (GSDMB) gene in the 17q21 locus were associated with lower asthma risk in both GERA (odds ratio, 0.92; P = 1.01 × 10 -6 ) and EVE (odds ratio, 0.85; joint P EVE = 1.31 × 10 -13 ). In GERA, rs11078928 had a minor allele frequency (MAF) of 0.45 in unaffected (nonasthmatic) controls and 0.43 in asthma cases. For European Americans in EVE, the MAF of rs2305480 was 0.45 for controls and 0.39 for cases; for all EVE subjects, the MAF was 0.32 for controls and 0.27 for cases. GSDMB is highly expressed in differentiated airway epithelial cells, including the ciliated cells. We found that, when the GSDMB protein is cleaved by inflammatory caspase-1 to release its N-terminal fragment, potent pyroptotic cell death is induced. The splice variant rs11078928 deletes the entire exon 6, which encodes 13 amino acids in the critical N-terminus, and abolishes the pyroptotic activity of the GSDMB protein. Our study identified a functional asthma variant in the GSDMB gene of the 17q21 locus and implicates GSDMB-mediated epithelial cell pyroptosis in pathogenesis. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
ACHP | Advisory Council on Historic Preservation News
Preserve America Community Blackstone River Valley Towns and Cities Designated Newest Preserve America Understanding Blackstone River Valley Presents 24 Preserve America Community Applications to the ACHP Laura Bush
All equine vets should wear helmets.
Shaw, Laura
2018-05-05
Laura Shaw argues that, due to the equine profession having the highest injury rate of all civilian professions, senior veterinary surgeons should take the lead in wearing helmets as routine. British Veterinary Association.
Adapting the Home After a Stroke
... and the Program in Occupational Therapy at Washington University in St. Louis School of Medicine . The research ... the Leonard Davis School of Gerontology at the University of Southern California), with additional contributions from Laura ...
Combined LAURA-UPS solution procedure for chemically-reacting flows. M.S. Thesis
NASA Technical Reports Server (NTRS)
Wood, William A.
1994-01-01
A new procedure seeks to combine the thin-layer Navier-Stokes solver LAURA with the parabolized Navier-Stokes solver UPS for the aerothermodynamic solution of chemically-reacting air flowfields. The interface protocol is presented and the method is applied to two slender, blunted shapes. Both axisymmetric and three dimensional solutions are included with surface pressure and heat transfer comparisons between the present method and previously published results. The case of Mach 25 flow over an axisymmetric six degree sphere-cone with a noncatalytic wall is considered to 100 nose radii. A stability bound on the marching step size was observed with this case and is attributed to chemistry effects resulting from the noncatalytic wall boundary condition. A second case with Mach 28 flow over a sphere-cone-cylinder-flare configuration is computed at both two and five degree angles of attack with a fully-catalytic wall. Surface pressures are seen to be within five percent with the present method compared to the baseline LAURA solution and heat transfers are within 10 percent. The effect of grid resolution is investigated and the nonequilibrium results are compared with a perfect gas solution, showing that while the surface pressure is relatively unchanged by the inclusion of reacting chemistry the nonequilibrium heating is 25 percent higher. The procedure demonstrates significant, order of magnitude reductions in solution time and required memory for the three dimensional case over an all thin-layer Navier-Stokes solution.
A resolution honoring the life and legacy of Laura Pollan.
Sen. Rubio, Marco [R-FL
2011-12-01
Senate - 02/14/2012 Placed on Senate Legislative Calendar under General Orders. Calendar No. 321. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:
Research Biologist with the EPA. Her current work involves linking natural and built infrastructure to human health and well-being at multiple spatial scales, in order to develop interpretive maps and analytical tools for an interactive, web-based Atlas.
NASA Astrophysics Data System (ADS)
Zhang, Sheng; Wang, Jian; Tang, Chao-Jing
2012-06-01
Counterfactual quantum cryptography, recently proposed by Noh, is featured with no transmission of signal particles. This exhibits evident security advantages, such as its immunity to the well-known photon-number-splitting attack. In this paper, the theoretical security of counterfactual quantum cryptography protocol against the general intercept-resend attacks is proved by bounding the information of an eavesdropper Eve more tightly than in Yin's proposal [Phys. Rev. A 82 042335 (2010)]. It is also shown that practical counterfactual quantum cryptography implementations may be vulnerable when equipped with imperfect apparatuses, by proving that a negative key rate can be achieved when Eve launches a time-shift attack based on imperfect detector efficiency.
Caregiving: It Takes a Village | NIH MedlinePlus the Magazine
... members, as an affordable caregiving option. Laura Gitlin, Ph.D., has been funded by NIH’s National Institute on Aging (NIA) for various trials that test ways to support family caregivers and informal caregivers. ...
2006-06-05
Space shuttle STS-121 FIT (Fly Immunity and Tumors) payload. Using Drosophila (fruit fly) to complete the experiments. Here we have sample preparation for post flight analysis of Drosophila (fruit fly) larva with Oana Marcu and Laura Higgins
U.S. Department of Defense Official Website
the President George W. Bush, his wife Laura, Vice-President Richard Cheney and his wife Lynne, to . Defense Dept. photo by Kathleen T. Rhem President George W. Bush delivers his inaugural address during the
78 FR 1143 - Explosive Siting Requirements; Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-08
... launch site operators in site planning for the storage and handling of energetic liquids and explosives...: For technical questions concerning this final rule, contact Yvonne Tran, Commercial Space... this final rule, contact Laura Montgomery, AGC 200, [[Page 1144
Mrs. Laura Bush Announces First Preserve America Grant Recipients,
Preservation; the U.S. Departments of Defense, Interior, Agriculture, Commerce, Housing and Urban Development . Department of Commerce seal U.S. Department of Agriculture logo U.S. Department of Housing and Urban
Computational Aerothermodynamic Simulation Issues on Unstructured Grids
NASA Technical Reports Server (NTRS)
Gnoffo, Peter A.; White, Jeffery A.
2004-01-01
The synthesis of physical models for gas chemistry and turbulence from the structured grid codes LAURA and VULCAN into the unstructured grid code FUN3D is described. A directionally Symmetric, Total Variation Diminishing (STVD) algorithm and an entropy fix (eigenvalue limiter) keyed to local cell Reynolds number are introduced to improve solution quality for hypersonic aeroheating applications. A simple grid-adaptation procedure is incorporated within the flow solver. Simulations of flow over an ellipsoid (perfect gas, inviscid), Shuttle Orbiter (viscous, chemical nonequilibrium) and comparisons to the structured grid solvers LAURA (cylinder, Shuttle Orbiter) and VULCAN (flat plate) are presented to show current capabilities. The quality of heating in 3D stagnation regions is very sensitive to algorithm options in general, high aspect ratio tetrahedral elements complicate the simulation of high Reynolds number, viscous flow as compared to locally structured meshes aligned with the flow.
Toward single electron resolution phonon mediated ionization detectors
NASA Astrophysics Data System (ADS)
Mirabolfathi, Nader; Harris, H. Rusty; Mahapatra, Rupak; Sundqvist, Kyle; Jastram, Andrew; Serfass, Bruno; Faiez, Dana; Sadoulet, Bernard
2017-05-01
Experiments seeking to detect rare event interactions such as dark matter or coherent elastic neutrino nucleus scattering are striving for large mass detectors with very low detection threshold. Using Neganov-Luke phonon amplification effect, the Cryogenic Dark Matter Search (CDMS) experiment is reaching unprecedented RMS resolutions of ∼14 eVee. CDMSlite is currently the most sensitive experiment to WIMPs of mass ∼5 GeV/c2 but is limited in achieving higher phonon gains due to an early onset of leakage current into Ge crystals. The contact interface geometry is particularly weak for blocking hole injection from the metal, and thus a new design is demonstrated that allows high voltage bias via vacuum separated electrode. With an increased bias voltage and a×2 Luke phonon gain, world best RMS resolution of sigma ∼7 eVee for 0.25 kg (d=75 mm, h=1 cm) Ge detectors was achieved. Since the leakage current is a function of the field and the phonon gain is a function of the applied voltage, appropriately robust interface blocking material combined with thicker substrate (25 mm) will reach a resolution of ∼2.8 eVee. In order to achieve better resolution of ∼ eV, we are investigating a layer of insulator between the phonon readout surface and the semiconductor crystals.
Foot strike pattern in preschool children during running: sex and shod-unshod differences.
Latorre-Román, Pedro Á; Párraga-Montilla, Juan A; Guardia-Monteagudo, Ignacio; García-Pinillos, Felipe
2018-04-01
This study aims to determine the foot strike patterns (FSPs) and neutral support (no inversion [INV]/eversion [EVE] and no foot rotation) in preschool children, as well as to determine the influence of shod/unshod conditions and sex. A total of 1356 children aged 3-6 years (673 boys and 683 girls) participated in this study. A sagittal and frontal-plane video (240 Hz) was recorded using a high-speed camcorder to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/ eversion (INV/EVE) and foot rotation on initial contact. There were no between-sex significant differences in both shod and unshod conditions in RFS. In the unshod condition, there was a significant reduction (p < 0.001) of RFS prevalence in both boys (shod condition = 44.2% vs. 34.7% unshod condition) and girls (shod condition = 48.5% vs. 36.1% unshod condition). As for neutral support, there were no between-sex differences in both shod and unshod conditions or in the shod-unshod comparison. In preschool children, no between-sex differences were found in relation to prevalence of RFS and neutral support (no INV/EVE). Shod running alters FSP of running barefoot, producing a significant increase of RFS prevalence.
Contextualising sexual harassment of adolescent girls in Bangladesh.
Nahar, Papreen; van Reeuwijk, Miranda; Reis, Ria
2013-05-01
Violence against women is a social mechanism confirming women's subordination in many societies. Sexual violence and harassment have various negative psychological impacts on girls, including a persistent feeling of insecurity and loss of self-esteem. This article aims to contextualize a particular form of sexual harassment, namely "eve teasing", experienced by Bangladeshi adolescent girls (12-18 years) which emerged from a study of adolescent sexual behaviour carried out by young people. The study used qualitative methods and a participatory approach, including focus group discussions, key informant interviews and observation. Despite taboos, unmarried adolescents actively seek information about sex, erotic pleasure and romance. Information was easily available from videos, mobile phone clips and pornographic magazines, but reinforced gender inequality. "Eve teasing" was one outlet for boys' sexual feelings; they gained pleasure from it and could show their masculinity. The girls disliked it and were afraid of being blamed for provoking it. Thus, "eve teasing" is a result of socio-cultural norms relating to sexuality, as well as a lack of access to sexual and reproductive health information and services in Bangladesh. These findings underscore the importance of comprehensive sexuality education that goes beyond a mere health focus and addresses gender norms and helps youth to gain social-sexual interaction skills. Copyright © 2013 Reproductive Health Matters. Published by Elsevier Ltd. All rights reserved.
Mohan, Atiharsh; Singh, Preet Mohinder; Malviya, Deepak; Arya, Sunil Kumar; Singh, Dinesh Kumar
2012-01-01
Background: Epidural volume extension (EVE) is claimed to increase the block height and decrease the dose requirement for intrathecal drug. However, almost all studies have been done in obstetric population and none actually compares the effect of additional drugs added to epidural volume. Materials and Methods: Seventy-five (ASA I and II) patients scheduled for lower abdominal surgery were randomly divided into three groups. All groups received intrathecal 10 mg bupivacaine; two groups received additional 10 ml of normal saline epidurally with 25 mg tramadol or 25 mg of fentanyl. Groups were than compared for maximal block height, rate of sensory block regression to T10, and motor block regression to Bromage scale of 0. Time to first analgesia and adverse effects were also compared among the three groups. Materials and Methods: Seventy-five (ASA I and II) patients scheduled for lower abdominal surgery were randomly divided into three groups. All groups received intrathecal 10 mg bupivacaine; two groups received additional 10 ml of normal saline epidurally with 25 mg tramadol or 25 mg of fentanyl. Groups were than compared for maximal block height, rate of sensory block regression to T10, and motor block regression to Bromage scale of 0. Time to first analgesia and adverse effects were also compared among the three groups. Results: Groups with EVE had statistically significant higher block height, with a significant faster regression that the control group. However, both fentanyl and tramadol groups were inseparable in respect to motor or sensory block regression. Fentanyl group had maximal time to first analgesia, followed by tramadol and control groups. Hemodynamic alterations were also more common in EVE groups. Conclusion: EVE can increase the block height significantly, but it seems to be limited only to the physical property of additional volume in epidural space and fentanyl or tramadol do not seem to differ in their ability to alter block properties. PMID:25885615
Ikin, Annat F; Causevic, Mirsada; Pedrini, Steve; Benson, Lyndsey S; Buxbaum, Joseph D; Suzuki, Toshiharu; Lovestone, Simon; Higashiyama, Shigeki; Mustelin, Tomas; Burgoyne, Robert D; Gandy, Sam
2007-01-01
Background Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have previously demonstrated that application of phorbol esters or purified PKC potentiates budding of APP-bearing secretory vesicles at the trans-Golgi network (TGN) and toward the plasma membrane where APP becomes a substrate for enzymes responsible for shedding, known collectively as α-secretase(s). However, molecular identification of the presumptive "phospho-state-sensitive modulators of ectodomain shedding" (PMES) responsible for regulated shedding has been challenging. Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1. Results Overexpression of either phorbol-sensitive wildtype Munc13-1 or phorbol-insensitive Munc13-1 H567K resulted in increased basal APP ectodomain shedding. However, in contrast to the report of Roßner et al (2004), phorbol ester-dependent APP ectodomain shedding from cells overexpressing APP and Munc13-1 wildtype was indistinguishable from that observed following application of phorbol to cells overexpressing APP and Munc13-1 H567K mutant. This pattern of similar effects on basal and stimulated APP shedding was also observed for Munc18 and NSF. Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious role in regulated shedding of sAPPα. Conclusion Our results indicate that, in the HEK293 system, Munc13-1, Munc18, NSF, and EVE-1 fail to meet essential criteria for identity as PMES for APP. PMID:18067682
Ikin, Annat F; Causevic, Mirsada; Pedrini, Steve; Benson, Lyndsey S; Buxbaum, Joseph D; Suzuki, Toshiharu; Lovestone, Simon; Higashiyama, Shigeki; Mustelin, Tomas; Burgoyne, Robert D; Gandy, Sam
2007-12-09
Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have previously demonstrated that application of phorbol esters or purified PKC potentiates budding of APP-bearing secretory vesicles at the trans-Golgi network (TGN) and toward the plasma membrane where APP becomes a substrate for enzymes responsible for shedding, known collectively as alpha-secretase(s). However, molecular identification of the presumptive "phospho-state-sensitive modulators of ectodomain shedding" (PMES) responsible for regulated shedding has been challenging. Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1. Overexpression of either phorbol-sensitive wildtype Munc13-1 or phorbol-insensitive Munc13-1 H567K resulted in increased basal APP ectodomain shedding. However, in contrast to the report of Rossner et al (2004), phorbol ester-dependent APP ectodomain shedding from cells overexpressing APP and Munc13-1 wildtype was indistinguishable from that observed following application of phorbol to cells overexpressing APP and Munc13-1 H567K mutant. This pattern of similar effects on basal and stimulated APP shedding was also observed for Munc18 and NSF. Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious role in regulated shedding of sAPPalpha. Our results indicate that, in the HEK293 system, Munc13-1, Munc18, NSF, and EVE-1 fail to meet essential criteria for identity as PMES for APP.
Two Different Rickettsial Bacteria Invading Volvox carteri
Kawafune, Kaoru; Hongoh, Yuichi; Hamaji, Takashi; Sakamoto, Tomoaki; Kurata, Tetsuya; Hirooka, Shunsuke; Miyagishima, Shin-ya; Nozaki, Hisayoshi
2015-01-01
Background Bacteria of the family Rickettsiaceae are principally associated with arthropods. Recently, endosymbionts of the Rickettsiaceae have been found in non-phagotrophic cells of the volvocalean green algae Carteria cerasiformis, Pleodorina japonica, and Volvox carteri. Such endosymbionts were present in only C. cerasiformis strain NIES-425 and V. carteri strain UTEX 2180, of various strains of Carteria and V. carteri examined, suggesting that rickettsial endosymbionts may have been transmitted to only a few algal strains very recently. However, in preliminary work, we detected a sequence similar to that of a rickettsial gene in the nuclear genome of V. carteri strain EVE. Methodology/Principal Findings Here we explored the origin of the rickettsial gene-like sequences in the endosymbiont-lacking V. carteri strain EVE, by performing comparative analyses on 13 strains of V. carteri. By reference to our ongoing genomic sequence of rickettsial endosymbionts in C. cerasiformis strain NIES-425 cells, we confirmed that an approximately 9-kbp DNA sequence encompassing a region similar to that of four rickettsial genes was present in the nuclear genome of V. carteri strain EVE. Phylogenetic analyses, and comparisons of the synteny of rickettsial gene-like sequences from various strains of V. carteri, indicated that the rickettsial gene-like sequences in the nuclear genome of V. carteri strain EVE were closely related to rickettsial gene sequences of P. japonica, rather than those of V. carteri strain UTEX 2180. Conclusion/Significance At least two different rickettsial organisms may have invaded the V. carteri lineage, one of which may be the direct ancestor of the endosymbiont of V. carteri strain UTEX 2180, whereas the other may be closely related to the endosymbiont of P. japonica. Endosymbiotic gene transfer from the latter rickettsial organism may have occurred in an ancestor of V. carteri. Thus, the rickettsiae may be widely associated with V. carteri, and likely have often been lost during host evolution. PMID:25671568
77 FR 25210 - Advisors Series Trust and Orinda Asset Management, LLC; Notice of Application
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-27
.... FOR FURTHER INFORMATION CONTACT: Laura L. Solomon, Senior Counsel, at (202) 551-6915, or Jennifer L..., and the four managing partners of the Advisor each have a minority interest in the Advisor. The...
75 FR 17928 - Nisso America, Inc.; Filing of Food Additive Petition
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-08
... dietary supplements. FOR FURTHER INFORMATION CONTACT: Laura Dye, Center for Food Safety and Applied... from 145 cPs to 10 cPs and to permit its use as a binder in dietary supplements. The agency has...
Communities Designated; Applications Available Preserve America Stewards Honored Preserve America Grants historic structures and assets. 736 Communities Designated; Applications Available 736 Communities Designated; Applications Available Just before leaving the White House, former First Lady Mrs. Laura Bush
77 FR 59114 - Cyazofamid; Pesticide Tolerances
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-26
...; Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This....regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the... CONTACT: Laura Nollen, Registration Division (7505P), Office of Pesticide Programs, Environmental...
76 FR 11337 - Presidential Library Facilities; Correction
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-02
... Presidential Library Facilities; Correction AGENCY: National Archives and Records Administration. ACTION... and design standards for Presidential libraries and information required in NARA's reports to Congress... Presidential library. DATES: This regulation is effective March 2, 2011. FOR FURTHER INFORMATION CONTACT: Laura...
Feminist Film Theory and Criticism.
ERIC Educational Resources Information Center
Mayne, Judith
1985-01-01
Discusses Laura Mulvey's 1975 essay, "Visual Pleasure and Narrative Cinema," and the ideas about feminist film theory and psychoanalysis as a critical tool which it raises. Suggests contradiction is the central issue in feminist film theory. Explores definitions of women's cinema. (SA)
Teacher is Space participant Christa McAuliffe during suite/hygiene briefing
NASA Technical Reports Server (NTRS)
1985-01-01
Teacher is Space participant Christa McAuliffe (right) is briefed on her suit and on personal hygiene equipment to be used on the STS 51-L mission. The briefing was conducted by Laura Louviere (center).
Women and Mathematics in the Time of Euler
ERIC Educational Resources Information Center
Mayfield, Betty
2013-01-01
We explore mathematics written both by and for women in eighteenth-century Europe, and some of the interesting personalities involved: Maria Agnesi, Emilie du Chatelet, Laura Bassi, Princess Charlotte Ludovica Luisa, John Colson, Francesco Algarotti, and Leonhard Euler himself.
NASA Astrophysics Data System (ADS)
Zapata, Mara
In this case study of a female science teacher named Laura, numerous observations, field notes, researcher interpretations, and assertions were developed. As meanings were negotiated, intent of actions was defined using significant statements, clustered to produce invariant meaning units. Both the participant's intents and how she interpreted her experiences were central to the understandings sought in this study. Whenever Laura planned for teaching science, taught, or otherwise interacted with students, the following four themes seemed to frame her actions: (1) Responsibility to Nurture/Mother/Mentor (2) Connecting to and Relating (3) Meeting Gender-Specific Expectations (4) Promoting the Fighter/Survivor Within. Each theme is examined in relation to attitudes and beliefs about teaching and learning science, and conclusions and assertions are expressed. The findings of this study point to the tensions between Laura's attitudes and beliefs and her pedagogical practices, disconfirming these as they pertain to gender in relation to teaching and learning science. It was not evident as part of her daily practice that student experiences were used in an attempt to create connections between their lives and science, although Laura always emphasized that science is a way of life. The findings support questioning the role of intentionality and a teacher's perceived ability to adhere to intentions while practicing within the norms established by the social institution of schools operating within the larger structures of society. The major findings and implications are relevant to the manner teachers are prepared and encouraged to enact their practice by departments and boards of education, prepared by institutions of higher education and subsequent participation in professional development. Specifically, calling attention to how these educational frameworks emphasize or de-emphasize the role of teachers and promote cognizance in terms of the culture of schools, reflective of the larger structures of society. Understanding the larger social structures and manner in which science in particular is formally packaged with its hegemonic reality and power arrangements reflective of such society is important if teachers are going to enact their practice in ways that facilitate this understanding to students. A lack of this understanding implicates that teachers enter the classroom without having developed a critical consciousness about societal structures and about schools as reproducers of the social and gender inequalities pervasive in society. (Abstract shortened by UMI.)
Plant protection in Poland on the eve of obligatory integrated pest management implementation.
Matyjaszczyk, Ewa
2013-09-01
Integrated pest management (IPM) will be obligatory in all European Union (EU) member states from January 1, 2014. Successful IPM implementation will depend not only on the sound guidelines and goodwill of the farmers, but also on conditions in farmers' environment. This paper presents the most important factors influencing IPM implementation in Poland. The most favorable aspects on the eve of obligatory IPM implementation are the relatively low use of plant protection products and popularity of some non-chemical methods of pest control, such as sowing cereal in mixture. The most important challenges are the improvement of advisory service and the crop structure with almost three-quarters of sown area covered by cereals. © 2013 Society of Chemical Industry.
... disorders. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 125. Review Date 8/22/2016 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine ...
78 FR 36011 - Notice of Senior Executive Service Performance Review Board Membership
Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-14
... Min* Van Nguyen DeBorah Russell Vance Teel Amy Thompson* Laura Train* *New Member Reginald F. Wells, Deputy Commissioner for Human Resources. [FR Doc. 2013-14200 Filed 6-13-13; 8:45 am] BILLING CODE 4191-02...
Instructional Technology. IDRA Focus.
ERIC Educational Resources Information Center
IDRA Newsletter, 1997
1997-01-01
This theme issue includes five articles that focus on implementing instructional technology in ways that benefit all students, including limited-English-proficient, minority, economically disadvantaged, and at-risk students. "Cruising the Web with English Language Learners" (Laura Chris Green) presents three scenarios using the World…
2002-11-07
KENNEDY SPACE CENTER, FLA. -- New methods of environmental cleanup are explained during a presentation to government and business representatives, scientists and engineers at Launch Complex 34-A, Cape Canaveral Spaceport. At left is Laura Filipek, a University of Central Florida graduate chemistry student involved in the science.
ERIC Educational Resources Information Center
IDRA Newsletter, 1995
1995-01-01
This theme issue contains six articles on improving math and science education for minority group students, particularly language-minority students. "Accelerating Content Area Gains for English Language Learners" (Laura Chris Green) describes the Young Scientists Acquiring English project, which seeks to improve the content-area…
SHORTER MENSTRUAL CYCLES ASSOCIATED WITH CHLORINATION BY-PRODUCTS IN DRINKING WATER
Shorter Menstrual Cycles Associated with Chlorination by-Products in Drinking Water.
Gayle Windham, Kirsten Waller, Meredith Anderson, Laura Fenster, Pauline Mendola, Shanna Swan. California Department of Health Services.
In previous studies of tap water consumption we...
77 FR 553 - Surety Companies Acceptable on Federal Bonds: Termination; Western Bonding Company
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-05
.... Department of the Treasury, Financial Management Service, Financial Accounting and Services Division, Surety..., 2011. Laura Carrico, Director, Financial Accounting and Services Division, Financial Management Service...: Termination; Western Bonding Company AGENCY: Financial Management Service, Fiscal Service, Department of the...
and Humanities; and the President's Council on Environmental Quality. The seal of the President of the Development logo Mrs. Laura Bush Announces Bipartisan Historic Preservation Legislation October 31, 2007 America and Save America's Treasures, announced introduction of bipartisan legislation authorizing two
76 FR 45303 - ING Asia Pacific High Dividend Equity Income Fund, et al.; Notice of Application
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-28
... 20006. FOR FURTHER INFORMATION CONTACT: Laura L. Solomon, Senior Counsel, at (202) 551-6915, or Daniele... meeting or within four months of the last day of such 12-week rolling period, the Board, including a...
78 FR 51740 - Agency Information Collection Activities: Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-21
... information collection, Registry of Climate Change Vulnerability Assessments. SUMMARY: We (the U.S. Geological... of Climate Change Vulnerability Assessments'' in the subject line. FOR FURTHER INFORMATION CONTACT: Laura Thompson, National Climate Change and Wildlife Science Center, U.S. Geological Survey, 12201...
Child Nutrition. Beginnings Workshop.
ERIC Educational Resources Information Center
Hayden, Jacqueline; Eastman, Wayne; Aird, Laura Dutil; McCrea, Nadine L.
2002-01-01
Four workshops focus on nutrition for infants and children in child care settings. Articles are: (1) "Nutrition and Child Development: Global Perspectives" (Jacqueline Hayden); (2) "Working with Families around Nutritional Issues" (Wayne Eastman); (3) "Breastfeeding Promotion in Child Care" (Laura Dutil Aird); and (4) "Food as Shared…
ERIC Educational Resources Information Center
Billings, Laura; Roberts, Terry
2014-01-01
Despite teachers' best intentions, traditional whole-class discussions sometimes end up sounding like the monotonous drone of Charlie Brown's teacher. But with careful planning, teachers can structure discussions that encourage meaningful student interaction and collaborative thinking, write Laura Billings and Terry Roberts of the…
Computation and Theory in Large-Scale Optimization
1993-01-13
Sang Jin Lee. Research Assistant. - Laura Morley, Research Assistant. - Yonca A. Ozge , Research Assistant. - Stephen M. Robinson. Professor. - Hichem...other participants. M.N. Azadez. S.J. Lee. Y.A. Ozge . and H. Sellami are continuing students in the doctoral program (in Industrial Engineering except
Wieman, S R; Didkovsky, L V; Judge, D L
The Solar EUV Monitor (SEM) onboard SOHO has measured absolute extreme ultraviolet (EUV) and soft X-ray solar irradiance nearly continuously since January 1996. The EUV Variability Experiment (EVE) on SDO, in operation since April of 2010, measures solar irradiance in a wide spectral range that encompasses the band passes (26 - 34 nm and 0.1 - 50 nm) measured by SOHO/SEM. However, throughout the mission overlap, irradiance values from these two instruments have differed by more than the combined stated uncertainties of the measurements. In an effort to identify the sources of these differences and eliminate them, we investigate in this work the effect of reprocessing the SEM data using a more accurate SEM response function (obtained from synchrotron measurements with a SEM sounding-rocket clone instrument taken after SOHO was already in orbit) and time-dependent, measured solar spectral distributions - i.e ., solar reference spectra that were unavailable prior to the launch of the SDO. We find that recalculating the SEM data with these improved parameters reduces mean differences with the EVE measurements from about 20 % to less than 5 % in the 26 - 34 nm band, and from about 35 % to about 15 % for irradiances in the 0.1 - 7 nm band extracted from the SEM 0.1 - 50 nm channel.
Geisler, Christoph; Jarvis, Donald L
2016-07-01
Spodoptera frugiperda (Sf) cell lines are used to produce several biologicals for human and veterinary use. Recently, it was discovered that all tested Sf cell lines are persistently infected with Sf-rhabdovirus, a novel rhabdovirus. As part of an effort to search for other adventitious viruses, we searched the Sf cell genome and transcriptome for sequences related to Sf-rhabdovirus. To our surprise, we found intact Sf-rhabdovirus N- and P-like ORFs, and partial Sf-rhabdovirus G- and L-like ORFs. The transcribed and genomic sequences matched, indicating the transcripts were derived from the genomic sequences. These appear to be endogenous viral elements (EVEs), which result from the integration of partial viral genetic material into the host cell genome. It is theoretically impossible for the Sf-rhabdovirus-like EVEs to produce infectious virus particles as 1) they are disseminated across 4 genomic loci, 2) the G and L ORFs are incomplete, and 3) the M ORF is missing. Our finding of transcribed virus-like sequences in Sf cells underscores that MPS-based searches for adventitious viruses in cell substrates used to manufacture biologics should take into account both genomic and transcribed sequences to facilitate the identification of transcribed EVE's, and to avoid false positive detection of replication-competent adventitious viruses. Copyright © 2016 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.
Geisler, Christoph; Jarvis, Donald L.
2016-01-01
Spodoptera frugiperda (Sf) cell lines are used to produce several biologicals for human and veterinary use. Recently, it was discovered that all tested Sf cell lines are persistently infected with Sf-rhabdovirus, a novel rhabdovirus. As part of an effort to search for other adventitious viruses, we searched the Sf cell genome and transcriptome for sequences related to Sf-rhabdovirus. To our surprise, we found intact Sf-rhabdovirus N- and P-like ORFs, and partial Sf-rhabdovirus G- and L-like ORFs. The transcribed and genomic sequences matched, indicating the transcripts were derived from the genomic sequences. These appear to be endogenous viral elements (EVEs), which result from the integration of partial viral genetic material into the host cell genome. It is theoretically impossible for the Sf-rhabdovirus-like EVEs to produce infectious virus particles as 1) they are disseminated across 4 genomic loci, 2) the G and L ORFs are incomplete, and 3) the M ORF is missing. Our finding of transcribed virus-like sequences in Sf cells underscores that MPS-based searches for adventitious viruses in cell substrates used to manufacture biologics should take into account both genomic and transcribed sequences to facilitate the identification of transcribed EVE's, and to avoid false positive detection of replication-competent adventitious viruses. PMID:27236849
Bootstrapping white matter segmentation, Eve++
NASA Astrophysics Data System (ADS)
Plassard, Andrew; Hinton, Kendra E.; Venkatraman, Vijay; Gonzalez, Christopher; Resnick, Susan M.; Landman, Bennett A.
2015-03-01
Multi-atlas labeling has come in wide spread use for whole brain labeling on magnetic resonance imaging. Recent challenges have shown that leading techniques are near (or at) human expert reproducibility for cortical gray matter labels. However, these approaches tend to treat white matter as essentially homogeneous (as white matter exhibits isointense signal on structural MRI). The state-of-the-art for white matter atlas is the single-subject Johns Hopkins Eve atlas. Numerous approaches have attempted to use tractography and/or orientation information to identify homologous white matter structures across subjects. Despite success with large tracts, these approaches have been plagued by difficulties in with subtle differences in course, low signal to noise, and complex structural relationships for smaller tracts. Here, we investigate use of atlas-based labeling to propagate the Eve atlas to unlabeled datasets. We evaluate single atlas labeling and multi-atlas labeling using synthetic atlases derived from the single manually labeled atlas. On 5 representative tracts for 10 subjects, we demonstrate that (1) single atlas labeling generally provides segmentations within 2mm mean surface distance, (2) morphologically constraining DTI labels within structural MRI white matter reduces variability, and (3) multi-atlas labeling did not improve accuracy. These efforts present a preliminary indication that single atlas labels with correction is reasonable, but caution should be applied. To purse multi-atlas labeling and more fully characterize overall performance, more labeled datasets would be necessary.
Evaluation of Atlas-Based White Matter Segmentation with Eve.
Plassard, Andrew J; Hinton, Kendra E; Venkatraman, Vijay; Gonzalez, Christopher; Resnick, Susan M; Landman, Bennett A
2015-03-20
Multi-atlas labeling has come in wide spread use for whole brain labeling on magnetic resonance imaging. Recent challenges have shown that leading techniques are near (or at) human expert reproducibility for cortical gray matter labels. However, these approaches tend to treat white matter as essentially homogeneous (as white matter exhibits isointense signal on structural MRI). The state-of-the-art for white matter atlas is the single-subject Johns Hopkins Eve atlas. Numerous approaches have attempted to use tractography and/or orientation information to identify homologous white matter structures across subjects. Despite success with large tracts, these approaches have been plagued by difficulties in with subtle differences in course, low signal to noise, and complex structural relationships for smaller tracts. Here, we investigate use of atlas-based labeling to propagate the Eve atlas to unlabeled datasets. We evaluate single atlas labeling and multi-atlas labeling using synthetic atlases derived from the single manually labeled atlas. On 5 representative tracts for 10 subjects, we demonstrate that (1) single atlas labeling generally provides segmentations within 2mm mean surface distance, (2) morphologically constraining DTI labels within structural MRI white matter reduces variability, and (3) multi-atlas labeling did not improve accuracy. These efforts present a preliminary indication that single atlas labels with correction is reasonable, but caution should be applied. To purse multi-atlas labeling and more fully characterize overall performance, more labeled datasets would be necessary.
And now, a word from our sponsor.
Peebles, M Ellen
2003-10-01
Bryant Pharmaceutical's flagship product, a popular arthritis medicine called Seflex, is selling well--but not well enough. With generic versions due on the shelves in a couple of years, the drug company is looking for a dramatic sales increase. No wonder marketing VP Laura Goldenberg feels the pressure. She knows she has to reach more consumers, but in an environment where people bombarded with advertising are using devices such as TiVo to skip ads, her job has suddenly taken on a new intensity. In search of a new, gangbuster campaign, Laura and her ad agency come up with the idea of product placement--not your typical integration of a product into a television or movie script, but a less traditional approach. Their idea is to hire a much-loved, elderly actress to extol the virtues of Seflex on a morning news program. The news segment would be about arthritis, and Seflex would be casually mentioned during the interview. The company would have to pay the actress $1 million, and there are risks: What if it gets out that Bryant is paying her? What if the actress errs and says something about Seflex's side effects? If something goes wrong, Bryant Pharmaceutical's reputation could suffer. Should the company green-light Laura's plan? This fictional case study looks at the pros and cons of traditional product placement and newer, more subtle alternatives to advertising. Commenting on the case are Bob Gamgort, president of Masterfoods USA; Michelle R. Nelson, an assistant professor of journalism and mass communications at the University of Wisconsin, Madison; FTC commissioner Mozelle W. Thompson; and Mike Sheehan, president and CEO of Hill, Holliday, Connors, Cosmopulos.
NASA Technical Reports Server (NTRS)
1997-01-01
This report summarizes work done under Cooperative Agreement (CA) on the following testbed projects: TERRIERS - The development of the ground systems to support the TERRIERS satellite mission at Boston University (BU). HSTS - The application of ARC's Heuristic Scheduling Testbed System (HSTS) to the EUVE satellite mission. SELMON - The application of NASA's Jet Propulsion Laboratory's (JPL) Selective Monitoring (SELMON) system to the EUVE satellite mission. EVE - The development of the EUVE Virtual Environment (EVE), a prototype three-dimensional (3-D) visualization environment for the EUVE satellite and its sensors, instruments, and communications antennae. FIDO - The development of the Fault-Induced Document Officer (FIDO) system, a prototype application to respond to anomalous conditions by automatically searching for, retrieving, and displaying relevant documentation for an operators use.
78 FR 13765 - Federal Acquisition Regulation; Definition of Contingency Operation
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-28
... Government procurement. Dated: February 20, 2013. Laura Auletta, Director, Office of Governmentwide... Regulation (FAR) to revise the definition of ``contingency operation'' to address the statutory change to the... change to http://www.regulations.gov , including any personal and/or business confidential information...
Technology in Education. IDRA Focus.
ERIC Educational Resources Information Center
IDRA Newsletter, 1995
1995-01-01
This theme issue includes four articles on the effective use of computers and electronic technology in education, and on equitable access to educational technologies for Hispanics and other minority groups. "Teachers and Instructional Technology: Wise or Foolish Choices" (Laura Chris Green) describes three unproductive roles for computer…
implications for energy technologies Research Interests Environmental effects of energy technologies and . Warner, and Dana Stright. 2016. Effects of Deployment Investment on the Growth of the Biofuels Industry . W. Bush. 2013. Effects of Deployment Investment on the Growth of the Biofuels Industry. Golden, CO
2008 Preserve America Presidential Awards
Project, New York, New York; Corinth and Alcorn County Mississippi Heritage Tourism Initiative; Lower East and Alcorn County Mississippi Heritage Tourism Initiative were Rosemary Williams, Chairperson, Siege Heritage Tourism Initiative Mrs. Laura Bush poses for a photo with Preserve America Presidential Award
75 FR 35815 - Ocean Transportation Intermediary License Applicants
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-23
..., TX 76011. Officers: Omar Kolaghassi, Manager (Qualifying Individual), Laura Alicia, Manager. Application Type: New OFF & NVO License. CALS Logistics USA, Inc. (OFF & NVO), 755 North Route 83, Suite 215.... Premium Star Logistics LLC dba O.P. Premium Star Logistics (OFF & NVO), 4200 Lightning Court, Bakersfield...
76 FR 9338 - List of Correspondence
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-17
... the Individuals with Disabilities Education Act (IDEA). Under section 607(f) of the IDEA, the... that describes the interpretations of the Department of the IDEA or the regulations that implement the IDEA. FOR FURTHER INFORMATION CONTACT: Laura Duos or Mary Louise Dirrigl. Telephone: (202) 245-7468. If...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-15
..., Government property, Indemnity payments, Insurance, Reporting and recordkeeping requirements, Rockets, Space...- Customer Commercial Space Launch and Reentry AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... INFORMATION CONTACT: Laura Montgomery, Senior Attorney for Commercial Space Transportation, Office of the...
ERIC Educational Resources Information Center
Singer, Alan, Ed.
2003-01-01
This theme based journal issue consists of articles and teaching ideas focusing on the Holocaust and history. This publication contains the following materials: (1) "Multiple Perspectives on the Holocaust?" (Alan Singer); (2) "Responses to 'Multiple Perspectives on the Holocaust'"; (3) "Escape to Cuba: Story of Laura Kahn,…
A resolution electing Laura C. Dove, of Virginia, as Secretary for the Minority of the Senate.
Sen. McConnell, Mitch [R-KY
2013-08-01
Senate - 08/01/2013 Submitted in the Senate, considered, and agreed to without amendment by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:
ERIC Educational Resources Information Center
1996
This document consists of three papers presented at a symposium on the learning organization moderated by Roger Miller at the 1996 conference of the Academy of Human Resource Development (AHRD). "Creating a Learning Organization: A Case Study of Outcomes and Lessons Learned" (Laura L. Bierema, David M. Berdish) reports a study…
Bean alpha-amylase inhibitors in transgenic peas inhibit development of pea weevil larvae.
de Sousa-Majer, Maria José; Hardie, Darryl C; Turner, Neil C; Higgins, Thomas J V
2007-08-01
This glasshouse study used an improved larval measurement procedure to evaluate the impact of transgenic pea, Pisum sativum L., seeds expressing a-amylase inhibitor (AI)-1 or -2 proteins on pea weevil, Bruchus pisorum L. Seeds of transgenic 'Laura' and 'Greenfeast' peas expressing alpha-(AI)-1 reduced pea weevil survival by 93-98%. Larval mortality occurred at an early instar. Conversely, in nontransgenic cultivars, approximately 98-99% of the pea weevils emerged as adults. By measuring the head capsule size, we determined that larvae died at the first to early third instar in alpha-(AI)-1 transgenic peas, indicating that this inhibitor is highly effective in controlling this insect. By contrast, transgenic Laura and 'Dundale' expressing alpha-(AI)-2 did not affect pea weevil survival, but they did delay larval development. After 77 d of development, the head capsule size indicated that the larvae were still at the third instar stage in transgenic alpha-(AI)-2 peas, whereas adult bruchids had developed in the nontransgenic peas.
Recent progress in density functional theory
NASA Astrophysics Data System (ADS)
Truhlar, Donald
2014-03-01
Ongoing work involves several areas of density functional theory: new methods for computing electronic excitation energies, including a new way to remove spin contamination in the spin-flip Tamm-Dancoff approximation and a configuration-interaction-corrected Tamm-Dancoff Approximation for treating conical intersections; new ways to treat open-shell states, including a reinterpreted broken-symmetry method and multi-configuration Kohn-Sham theory; a new exchange-correlation functional; new tests of density functional theory against databases for electronic transition energies and molecules and solids containing metal atoms; and applications. A selection of results will be presented. I am grateful to the following collaborators for contributions to the ongoing work: Boris Averkiev, Rebecca Carlson, Laura Fernandez, Laura Gagliardi, Chad Hoyer, Francesc Illas, Miho Isegawa, Shaohong Li, Giovanni Li Manni, Sijie Luo, Dongxia Ma, Remi Maurice, Rubén Means-Pañeda, Roberto Peverati, Nora Planas, Prasenjit Seal, Pragya Verma, Bo Wang, Xuefei Xu, Ke R. Yang, Haoyu Yu, Wenjing Zhang, and Jingjing Zheng. Supported in part by the AFOSR and U.S. DOE.
ERIC Educational Resources Information Center
Marrah, Arleezah; Mills, Roxanne
2011-01-01
This article describes the Librarianship Upgrades for Children and Youth Services (LUCY), a multifaceted multicultural continuing education program for librarians developed by the Library and Information Science Program at Old Dominion University. The Institute of Museum and Library Services (IMLS) funds LUCY through the Laura Bush 21st century…
Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-24
... Bertsch, President and CEO, Society of Corporate Secretaries & Governance Professionals, dated March 7... March 14, 2013 (``Harrington Letter''); James McRitchie, Shareowner, Corporate Governance, dated March... March 15, 2013 (``Sharegate Letter''); Laura Berry, Executive Director, Interfaith Center on Corporate...
TIME TO PREGNANCY IN RELATION TO TOTAL TRIHALOMETHANE LEVELS IN TAP WATER
Time to pregnancy in relation to total trihalomethane levels in tap water
Shanna H. Swan, Cuirong Ren, Gayle C. Windham, Laura Fenster, Kirsten Waller. (University of Missouri and California Department of Health Services).
We have previously reported increased risks o...
77 FR 10806 - Surety Companies Acceptable on Federal Bonds: Termination; First Sealord Surety, Inc.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-23
... 20782. Dated: February 10, 2012. Laura Carrico, Director, Financial Accounting and Services Division...: Termination; First Sealord Surety, Inc. AGENCY: Financial Management Service, Fiscal Service, Department of... be directed to the U.S. Department of the Treasury, Financial Management Service, Financial...
75 FR 60865 - Surety Companies Acceptable on Federal Bonds: Amendment-Allegheny Casualty Company
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-01
... 20782. Dated: September 24, 2010. Laura Carrico, Director, Financial Accounting and Services Division...-- Allegheny Casualty Company AGENCY: Financial Management Service, Fiscal Service, Department of the Treasury... notice may be directed to the U.S. Department of the Treasury, Financial Management Service, Financial...
75 FR 61246 - Surety Companies Acceptable on Federal Bonds: Darwin National Assurance Company
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-04
... the U.S. Department of the Treasury, Financial Management Service, Financial Accounting and Services..., 2010. Laura Carrico, Director, Financial Accounting and Services Division, [FR Doc. 2010-24632 Filed 10... National Assurance Company AGENCY: Financial Management Service, Fiscal Service, Department of the Treasury...
ERIC Educational Resources Information Center
McGarvey, Lynn M.; Sterenberg, Gladys Y.; Long, Julie S.
2013-01-01
The authors elucidate what they saw as three important challenges to overcome along the path to becoming elementary school mathematics teacher leaders: marginal interest in math, low self-confidence, and teaching in isolation. To illustrate how these challenges were mitigated, they focus on the stories of two elementary school teachers--Laura and…
Standards and Assessment. IDRA Focus.
ERIC Educational Resources Information Center
IDRA Newsletter, 1997
1997-01-01
This newsletter includes three articles, two of which focus on standards for student evaluation and for admission to higher education. "A Measuring Stick for Standards and TEKS: Meeting the Needs of Second Language Learners" (Laura Chris Green, Adela Solis) examines beliefs embodied in the notion of standards; defines content,…
ERIC Educational Resources Information Center
Hetrick, Laura J.
2013-01-01
In this commentary, Laura Hetrick focuses on what is inherently missing from the art education literature about teaching future teachers of art--of addressing nascent teachers' personal, pedagogical, and professional desires. Specifically, she considers teachers' desires for power and recognition, their desires to love and be loved, and…
CHLORINATION BY-PRODUCTS IN DRINKING WATER AND MENSTRUAL CYCLE FUNCTION
Chlorination by-Products in Drinking Water and Menstrual Cycle Function
Gayle C. Windham1, Kirsten Waller2, Meredith Anderson2, Laura Fenster1, Pauline Mendola3, Shanna Swan4
1California Department of Health Services, Division of Environmental and Occupational Disea...
76 FR 17817 - North Central Idaho Resource Advisory Committee
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-31
... Central Idaho Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The North Central Idaho RAC will meet in Grangeville, Idaho. The committee is meeting as authorized... Supervisors Office, 104 Airport Road, Grangeville, Idaho. Written comments should be sent to Laura Smith at...
Federal Support for Preserve America
Development logo Mrs. Laura Bush Presents "Preserve America History Teacher of the Year" Award to , West Virginia, the 2006 "Preserve America History Teacher of the Year" Award during a ceremony held at Lincoln Hall in The Union League Club. "Great history teachers take required
77 FR 20531 - Correction of Authority Citations for Commercial Space Transportation
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-05
...-AI50, 2120-AI57, 2120-AI56, 2120-AI88] Correction of Authority Citations for Commercial Space..., Congress transferred the statute authorizing the FAA's commercial space transportation regulations. This...: Laura Montgomery, Senior Attorney for Commercial Space Transportation, Office of the Chief Counsel...
Philanthropy and the Gospel of Child Development.
ERIC Educational Resources Information Center
Schlossman, Steven
1981-01-01
Highlights the role of the Laura Spelman Rockefeller Memorial Foundation in promoting child development research and parent education in America during the 1920s. The author discusses the ways that the movement's stress on scientific objectivity help to increase its acceptance by both parents and educators. (AM)
Disciplined Development: Teachers and Reform in Ghana
ERIC Educational Resources Information Center
Dull, Laura J.
2006-01-01
Drawing on Foucault's analysis of disciplinary power and Gramsci's theories on hegemony, Laura Dull argues in this insightful volume that Ghanian teachers' diverse roles--as moral disciplinarians, ambivalent partners with global donors and lenders, romantic racialists of Africans--illustrate the ways in which educators deploy history and…
76 FR 72003 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-21
... responses. ADDRESSES: Send comments to: Matthew Birnbaum, Ph.D., Evaluation and Research Officer, Institute... the Institute. Current research initiatives include analysis of grants made to educational and... communities. IMLS proposes to collect qualitative and quantitative information from grant recipients and...
Honey, Laura
2015-12-05
Benefits of the human-animal bond are often highlighted, but how equal is the relationship? Delegates at the BVA Congress at the London Vet Show heard that, while animals can bring benefits to people, people do not always fulfil their side of the bargain. Laura Honey reports. British Veterinary Association.
ERIC Educational Resources Information Center
Bush, Laura
2005-01-01
As First Lady of the United States, Laura Bush is leading the Helping America's Youth initiative of the federal government. She articulates the goal of enlisting public and volunteer resources to foster healthy growth by early intervention and mentoring of youngsters at risk. Helping America's Youth will benefit children and teenagers by…
Then and Now: Women Respond to the Manhattan Project - an illustrated talk
NASA Astrophysics Data System (ADS)
Fermi, M. A., Olivia
2014-03-01
I am very much looking forward to visiting you, the family of physicists gathering for your annual APS conference. In different ways, my grandfather Enrico Fermi is a member of both our families. In this sense we are connected and share a common legacy, which I want to explore from the angle of two women inextricably involved with and affected by the Manhattan Project. One from the past and one alive now. These two women, despite a significant temporal and cultural gap share a remarkable number of traits and values. My talk will not offer a particular thesis or finding. Rather it will be about ways of seeing, including questioning unnoticed assumptions and belief systems. My grandmother Laura Fermi, modeled this for me as a youngster. She was at Enrico's side during the Manhattan Project years, yet in the dark about his work. What was it like to live in a climate of intellectually and patriotically charged enthusiasm, with an undercurrent of unspoken dread? Laura, just like most everyone else, discovered the true nature of the effort on the day the atomic bomb was dropped on Hiroshima. After the war and after Enrico's untimely death in 1954, in response to all she had experienced, Laura re-invented herself as an author and visionary, pioneering in both the environmental and handgun control movements. Marian Naranjo lives on the Santa Clara Pueblo near Los Alamos. Her ancestors dwelled on the Pajarito Plateau which encompasses the space where Los Alamos National Labs (LANL) is today. Her people, the Pueblo People have used the area's natural resources for ceremonial and survival for uncountable generations. They say, ``We are this place.'' What is it like to live on land one's families have safely occupied for thousands of years, with an undercurrent of dread at the prospect of toxic waste stream products from LANL? Like my grandmother did in her place and time, Marian builds community as an integral part of her environmental and social justice activism. She is regularly a presenter at the table with LANL, DOE and other organizations; and also works to empower women and youth. Laura and Marian's lives illustrate the potential for engaged response to the Manhattan Project and its legacy. Implicit in them are fundamental moral and ethical questions. What is the nature of individual responsibility? Does it differ for men and women? How does the interplay between masculine and feminine forces affect our culture, and what does it imply for our future?
Accessible transportation technologies research initiative (ATTRI).
DOT National Transportation Integrated Search
2016-01-01
For people with disabilities, including injured veterans and older adults, inadequate mobility and transportation can hinder them from completing important tasks, such as obtaining employment, commuting to appointments, shopping for groceries, or eve...
Conversation Currents: Learning from Families and Communities
ERIC Educational Resources Information Center
Compton-Lilly, Catherine; Gregory, Eve
2013-01-01
This column features two prominent literacy scholars, Catherine Compton-Lilly and Eve Gregory. They discuss their recent research studies in various contexts and describe the reciprocal relationships between school, home, and community literacy practices.
Wearable design issues for electronic vision enhancement systems
NASA Astrophysics Data System (ADS)
Dvorak, Joe
2006-09-01
As the baby boomer generation ages, visual impairment will overtake a significant portion of the US population. At the same time, more and more of our world is becoming digital. These two trends, coupled with the continuing advances in digital electronics, argue for a rethinking in the design of aids for the visually impaired. This paper discusses design issues for electronic vision enhancement systems (EVES) [R.C. Peterson, J.S. Wolffsohn, M. Rubinstein, et al., Am. J. Ophthalmol. 136 1129 (2003)] that will facilitate their wearability and continuous use. We briefly discuss the factors affecting a person's acceptance of wearable devices. We define the concept of operational inertia which plays an important role in our design of wearable devices and systems. We then discuss how design principles based upon operational inertia can be applied to the design of EVES.
Three-step semiquantum secure direct communication protocol
NASA Astrophysics Data System (ADS)
Zou, XiangFu; Qiu, DaoWen
2014-09-01
Quantum secure direct communication is the direct communication of secret messages without need for establishing a shared secret key first. In the existing schemes, quantum secure direct communication is possible only when both parties are quantum. In this paper, we construct a three-step semiquantum secure direct communication (SQSDC) protocol based on single photon sources in which the sender Alice is classical. In a semiquantum protocol, a person is termed classical if he (she) can measure, prepare and send quantum states only with the fixed orthogonal quantum basis {|0>, |1>}. The security of the proposed SQSDC protocol is guaranteed by the complete robustness of semiquantum key distribution protocols and the unconditional security of classical one-time pad encryption. Therefore, the proposed SQSDC protocol is also completely robust. Complete robustness indicates that nonzero information acquired by an eavesdropper Eve on the secret message implies the nonzero probability that the legitimate participants can find errors on the bits tested by this protocol. In the proposed protocol, we suggest a method to check Eves disturbing in the doves returning phase such that Alice does not need to announce publicly any position or their coded bits value after the photons transmission is completed. Moreover, the proposed SQSDC protocol can be implemented with the existing techniques. Compared with many quantum secure direct communication protocols, the proposed SQSDC protocol has two merits: firstly the sender only needs classical capabilities; secondly to check Eves disturbing after the transmission of quantum states, no additional classical information is needed.
Low-mass dark matter search with CDMSlite
NASA Astrophysics Data System (ADS)
Agnese, R.; Anderson, A. J.; Aralis, T.; Aramaki, T.; Arnquist, I. J.; Baker, W.; Balakishiyeva, D.; Barker, D.; Basu Thakur, R.; Bauer, D. A.; Binder, T.; Bowles, M. A.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Calkins, R.; Cartaro, C.; Cerdeño, D. G.; Chang, Y.; Chagani, H.; Chen, Y.; Cooley, J.; Cornell, B.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Esteban, L.; Fascione, E.; Figueroa-Feliciano, E.; Fritts, M.; Gerbier, G.; Ghaith, M.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hong, Z.; Hoppe, E. W.; Hsu, L.; Huber, M. E.; Iyer, V.; Jardin, D.; Jastram, A.; Jena, C.; Kelsey, M. H.; Kennedy, A.; Kubik, A.; Kurinsky, N. A.; Leder, A.; Loer, B.; Lopez Asamar, E.; Lukens, P.; MacDonell, D.; Mahapatra, R.; Mandic, V.; Mast, N.; Miller, E. H.; Mirabolfathi, N.; Moffatt, R. A.; Mohanty, B.; Morales Mendoza, J. D.; Nelson, J.; Orrell, J. L.; Oser, S. M.; Page, K.; Page, W. A.; Partridge, R.; Pepin, M.; Peñalver Martinez, M.; Phipps, A.; Poudel, S.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Reynolds, T.; Roberts, A.; Robinson, A. E.; Rogers, H. E.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Scorza, S.; Senapati, K.; Serfass, B.; Speller, D.; Stein, M.; Street, J.; Tanaka, H. A.; Toback, D.; Underwood, R.; Villano, A. N.; von Krosigk, B.; Welliver, B.; Wilson, J. S.; Wilson, M. J.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, X.; Zhao, X.; SuperCDMS Collaboration
2018-01-01
The SuperCDMS experiment is designed to directly detect weakly interacting massive particles (WIMPs) that may constitute the dark matter in our Galaxy. During its operation at the Soudan Underground Laboratory, germanium detectors were run in the CDMSlite mode to gather data sets with sensitivity specifically for WIMPs with masses <10 GeV /c2 . In this mode, a higher detector-bias voltage is applied to amplify the phonon signals produced by drifting charges. This paper presents studies of the experimental noise and its effect on the achievable energy threshold, which is demonstrated to be as low as 56 eVee (electron equivalent energy). The detector-biasing configuration is described in detail, with analysis corrections for voltage variations to the level of a few percent. Detailed studies of the electric-field geometry, and the resulting successful development of a fiducial parameter, eliminate poorly measured events, yielding an energy resolution ranging from ˜9 eVee at 0 keV to 101 eVee at ˜10 keVee . New results are derived for astrophysical uncertainties relevant to the WIMP-search limits, specifically examining how they are affected by variations in the most probable WIMP velocity and the Galactic escape velocity. These variations become more important for WIMP masses below 10 GeV /c2 . Finally, new limits on spin-dependent low-mass WIMP-nucleon interactions are derived, with new parameter space excluded for WIMP masses ≲3 GeV /c2.
Analyses of interactions among pair-rule genes and the gap gene Krüppel in Bombyx segmentation.
Nakao, Hajime
2015-09-01
In the short-germ insect Tribolium, a pair-rule gene circuit consisting of the Tribolium homologs of even-skipped, runt, and odd-skipped (Tc-eve, Tc-run and Tc-odd, respectively) has been implicated in segment formation. To examine the application of the model to other taxa, I studied the expression and function of pair-rule genes in Bombyx mori, together with a Bombyx homolog of Krüppel (Bm-Kr), a known gap gene. Knockdown embryos of Bombyx homologs of eve, run and odd (Bm-eve, Bm-run and Bm-odd) exhibited asegmental phenotypes similar to those of Tribolium knockdowns. However, pair-rule gene interactions were similar to those of both Tribolium and Drosophila, which, different from Tribolium, shows a hierarchical segmentation mode. Additionally, the Bm-odd expression pattern shares characteristics with those of Drosophila pair-rule genes that receive upstream regulatory input. On the other hand, Bm-Kr knockdowns exhibited a large posterior segment deletion as observed in short-germ insects. However, a detailed analysis of these embryos indicated that Bm-Kr modulates expression of pair-rule genes like in Drosophila, although the mechanisms appear to be different. This suggested hierarchical interactions between Bm-Kr and pair-rule genes. Based on these results, I concluded that the pair-rule gene circuit model that describes Tribolium development is not applicable to Bombyx. Copyright © 2015 Elsevier Inc. All rights reserved.
Ionospheric Change and Solar EUV Irradiance
NASA Astrophysics Data System (ADS)
Sojka, J. J.; David, M.; Jensen, J. B.; Schunk, R. W.
2011-12-01
The ionosphere has been quantitatively monitored for the past six solar cycles. The past few years of observations are showing trends that differ from the prior cycles! Our good statistical relationships between the solar radio flux index at 10.7 cm, the solar EUV Irradiance, and the ionospheric F-layer peak density are showing indications of divergence! Present day discussion of the Sun-Earth entering a Dalton Minimum would suggest change is occurring in the Sun, as the driver, followed by the Earth, as the receptor. The dayside ionosphere is driven by the solar EUV Irradiance. But different components of this spectrum affect the ionospheric layers differently. For a first time the continuous high cadence EUV spectra from the SDO EVE instrument enable ionospheric scientists the opportunity to evaluate solar EUV variability as a driver of ionospheric variability. A definitive understanding of which spectral components are responsible for the E- and F-layers of the ionosphere will enable assessments of how over 50 years of ionospheric observations, the solar EUV Irradiance has changed. If indeed the evidence suggesting the Sun-Earth system is entering a Dalton Minimum periods is correct, then the comprehensive EVE solar EUV Irradiance data base combined with the ongoing ionospheric data bases will provide a most fortuitous fiduciary reference baseline for Sun-Earth dependencies. Using the EVE EUV Irradiances, a physics based ionospheric model (TDIM), and 50 plus years of ionospheric observation from Wallops Island (Virginia) the above Sun-Earth ionospheric relationship will be reported on.
ERIC Educational Resources Information Center
Bibel, Barbara
2010-01-01
This article presents an annotated bibliography of 19 titles that focus on cancer and health-care reform. These include: (1) Anderson, John W. "Stand by Her: A Breast Cancer Guide for Men." AMACOM: American Management Assn.; (2) Carstensen, Laura L. "A Long Bright Future: An Action Plan for a Lifetime of Happiness, Health, and Financial Security."…
PROSPECTIVE PREGNANCY STUDY DESIGNS FOR ASSESSING REPRODUCTIVE AND DEVELOPMENTAL TOXICANTS
Prospective Pregnancy Study Designs for Assessing Reproductive and Developmental Toxicants
Germaine M. Buck,1 Courtney D. Johnson,1 Joseph Stanford,2 Anne Sweeney,3 Laura Schieve,4 John Rockett,5 Sherry G. Selevan,6 Steve Schrader 7
Abstract
The origin of successfu...
Sen. Reid, Harry [D-NV
2013-07-15
Senate - 07/15/2013 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-30
... directed to the U.S. Department of the Treasury, Financial Management Service, Financial Accounting and...: June 22, 2011. Laura Carrico, Director, Financial Accounting and Services Division, Financial...: Financial Management Service, Fiscal Service, Department of the Treasury. ACTION: Notice. SUMMARY: This is...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-05
... directed to the U.S. Department of the Treasury, Financial Management Service, Financial Accounting and...: April 22, 2011. Laura Carrico, Director, Financial Accounting and Services Division. [FR Doc. 2011-10773... Change: Odyssey America Reinsurance Corporation AGENCY: Financial Management Service, Fiscal Service...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-05
..., Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: December 20, 2011. Laura Carrico, Director, Financial Accounting and Services...-- Evergreen National Indemnity Company AGENCY: Financial Management Service, Fiscal Service, Department of the...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-17
..., Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: May 8, 2012. Laura Carrico, Director, Financial Accounting and Services Division...--Termination: Atlantic Bonding Company, Inc. AGENCY: Financial Management Service, Fiscal Service, Department...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-29
... 20782. Dated: September 15, 2011. Laura Carrico, Director, Financial Accounting and Services Division...: Termination; Minnesota Surety and Trust Company AGENCY: Financial Management Service, Fiscal Service... notice may be directed to the U.S. Department of the Treasury, Financial Management Service, Financial...
77 FR 27253 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-09
... information gathered will inform the library and information science field of innovations and best practices... Century Librarian Grant Program Evaluation AGENCY: Institute of Museum and Library Services, National.... SUMMARY: The Institute of Museum and Library Services announces the following information collection has...
ERIC Educational Resources Information Center
Pannapacker, William
2012-01-01
In this article, the author discusses digital humanities (DH) and what future it holds for graduate students who are riding the digital-humanities bandwagon. He spoke with several graduate students about their interest in the field: how they got into it and began their first projects. Laura Mandell, director of the Initiative for Digital…
Literary Study, Measurement, and the Sublime: Disciplinary Assessment
ERIC Educational Resources Information Center
Heiland, Donna, Ed.; Rosenthal, Laura J., Ed.
2011-01-01
This collection of essays, "Literary Study, Measurement, and the Sublime: Disciplinary Assessment," edited by Donna Heiland and Laura J. Rosenthal, represents an important new venture in the Foundation's communication program. The book is the product of many authors, including the editors, both of whom have written essays for it. But it…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-26
... the EIS could be completed, the funding reality is such that the project could not be designed or... and Construction (A, B). Authority: 23 U.S.C. 315; 49 CFR 1.48. Issued on: April 16, 2012. Laura S...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-14
... 2] RIN 9000-AL55 Federal Acquisition Regulation; Justification and Approval of Sole-Source 8(a... removes language indicating that the applicable section of the National Defense Authorization Act for...: June 8, 2012. Laura Auletta, Director, Office of Governmentwide Acquisition Policy, Office of...
75 FR 57904 - Mid-Atlantic Fishery Management Council (MAFMC); Meetings
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-23
... receive a MARCO presentation by Laura McKay, Program Manager Virginia Coastal Zone Program. The Council... Ecosystems and Oceans Planning Committee, its Demersal and Coastal Migratory Committee, its Law Enforcement... Coastal Migratory Committee will meet from 4 p.m. until 5 p.m. The Law Enforcement Committee will meet...
Diversity in the Workplace [in HRD].
ERIC Educational Resources Information Center
1995
These four papers are from a symposium that was facilitated by Laura Bierema at the 1995 conference of the Academy of Human Resource Development (HRD). "The Status of Valuing and Managing Diversity in Fortune 500 Manufacturing and Fortune 500 Service Organizations: Perceptions of Top Human Resource Professionals" (Sandra J. Johnson) reports a…
TRIHALOMETHANE LEVELS IN HOME TAP WATER AND SEMEN QUALITY
Trihalomethane Levels in Home Tap Water and Semen Quality
Laura Fenster, 1 Kirsten Waller, 2 Gayle Windham, 1 Tanya Henneman, 2 Meredith Anderson, 2 Pauline Mendola, 3 James W. Overstreet, 4 Shanna H. Swan5
1California Department of Health Services, Division of Environm...
Postsecondary Education and Transition for Students with Learning Disabilities. Second Edition.
ERIC Educational Resources Information Center
Brinckerhoff, Loring C.; McGuire, Joan M.; Shaw, Stan F.
This text is designed to help postsecondary education personnel initiate or refine college programs for the increasing numbers of students with learning disabilities. Following an introductory chapter, chapters have the following titles: (1) "A Comprehensive Approach to Transition Planning"; (2) "Judicial Intent and Legal Precedents" (Laura F.…
Losing Libraries, Saving Libraries
ERIC Educational Resources Information Center
Miller, Rebecca
2010-01-01
This summer, as public libraries continued to get budget hit after budget hit across the country, several readers asked for a comprehensive picture of the ravages of the recession on library service. In partnership with 2010 Movers & Shakers Laura Solomon and Mandy Knapp, Ohio librarians who bought the Losing Libraries domain name,…
ERIC Educational Resources Information Center
2002
This symposium is comprised of three papers on issues of gender in human resource development (HRD). "The Impact of Awareness and Action on the Implementation of a Women's Network" (Laura L. Bierema) reports on research to examine how gender consciousness emerges through the formation of in-company networks to promote corporate women's…
Early Years Children Think Too!
ERIC Educational Resources Information Center
Mooney, Laura
2013-01-01
During a recent theme on "Ourselves," Laura Mooney's class focused on height and looking at similarities and differences between a range of objects. This involved not only looking at each other, but also linked to their self-portrait development, where they had been learning about their facial features and comparing them to other…
Runoff Characterization and Variations at McMurdo Station, Antarctica
2014-05-13
Boulevard Arlington, VA 22230 Laura Elliot and Corey Chan Antarctic Support Contract 7400 S. Tucson Way Centennial , CO 08112 Michael Diamond...then along the road and down Hut Point Road. Sub-basin 2 has the largest area and encompasses the majority of the snowfield and the depression above
ERIC Educational Resources Information Center
Nebraska Univ., Lincoln.
This volume on the Tri-University project contains three reports on the teaching of oracy. The chairman of the committee on oracy, Laura Chase, offers suggestions for the preservice and inservice training of teachers to prepare them to deal with discussion, the individual talk, oral reading, and dramatic role playing. She outlines a teacher…
2005-09-01
Screen break: nursing students Jackie Walsh, Laura Robinson and Liz Midgley join 'matron' Sandra McQuat, a ward manager at Beatson Oncology Centre, the Western Infirmary, Glasgow, as they try out nurse training 1950s style for a new BBC series to be televised this autumn. The series, Thoroughly Modern Matron, was filmed at Belvoir Park Hospital, Belfast.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-16
... Installation Designated for Disposal: Naval Air Station Alameda, Alameda, California AGENCY: Department of the... at Naval Air Station Alameda, Alameda, California. FOR FURTHER INFORMATION CONTACT: Ms. Laura Duchnak, Director, Naval Facilities Engineering Command, Base Realignment and Closure Program Management Office...
Harvard Education Letter. Volume 26, Number 5, September-October 2010
ERIC Educational Resources Information Center
Walser, Nancy, Ed.
2010-01-01
"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Scenes from the School Turnaround Movement: Passion, Frustration, Mid-Course Corrections Mark Rapid Reforms (Laura Pappano); (2) The Media Savvy Educator:…
"Never Enough": Bridging the Chasm between College Women's Achievements and Their Anguish
ERIC Educational Resources Information Center
Choate, Laura A.
2017-01-01
Laura H. Choate demonstrates a disconnect between what female undergraduates are achieving and how they actually feel about themselves and their accomplishments; she suggests a variety of interventions to counterbalance the cultural pressures that undermine college women's overall self-esteem and mental health.
Palliative care - what the final days are like
... do symptoms change for patients in the last days and hours of life? In: Goldstein NE, Morrison RS, eds. Evidence-Based Practice of Palliative Medicine . Philadelphia, PA: Elsevier Saunders; 2013:chap 39. Review Date 2/6/2016 Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal ...
STS-115 MS Tanner on Atlantis Middeck
2006-09-10
S115-E-05337 (10 Sept. 2006) --- Astronaut Joseph R. Tanner, STS-115 mission specialist, works on the middeck of the Space Shuttle Atlantis on the eve of docking day with the International Space Station.
Poindexter in hatch area of MDDK during STS-122
2008-02-08
S122-E-006223 (8 Feb. 2008) --- Astronaut Alan Poindexter, STS-122 pilot, passes through a tunnel on the Space Shuttle Atlantis on the eve of the docking of the shuttle to the International Space Station.
Cardiovascular hospitalizations and associations with environmental quality
Cardiovascular disease has been identified as a condition that may be associated with environmental factors. Air pollution in particular has been demonstrated to be associated with cardiovascular disease and atherosclerosis, which can increase the likelihood of cardiovascular eve...
2014-01-01
Scientists go to great lengths to ensure that data are collected and analysed properly, so why, asks Eve Marder, do they apply different standards to data about the number of times research papers have been cited and viewed? PMID:24692454
Supernova Argonne/HEP Dark Energy Survey Group Ravi Gupta, Eve Kovacs, Steve Kuhlmann, Hal Spinka, Kasia Pomian The Argonne/HEP Dark Energy Survey (DES) group worked to build and test the Dark Energy Camera
Analysis of Forgery Attack on One-Time Proxy Signature and the Improvement
NASA Astrophysics Data System (ADS)
Wang, Tian-Yin; Wei, Zong-Li
2016-02-01
In a recent paper, Yang et al. (Quant. Inf. Process. 13(9), 2007-2016, 2014) analyzed the security of one-time proxy signature scheme Wang and Wei (Quant. Inf. Process. 11(2), 455-463, 2012) and pointed out that it cannot satisfy the security requirements of unforgeability and undeniability because an eavesdropper Eve can forge a valid proxy signature on a message chosen by herself. However, we find that the so-called proxy message-signature pair forged by Eve is issued by the proxy signer in fact, and anybody can obtain it as a requester, which means that the forgery attack is not considered as a successful attack. Therefore, the conclusion that this scheme cannot satisfy the security requirements of proxy signature against forging and denying is not appropriate in this sense. Finally, we study the reason for the misunderstanding and clarify the security requirements for proxy signatures.
A Looping-Based Model for Quenching Repression
Pollak, Yaroslav; Goldberg, Sarah; Amit, Roee
2017-01-01
We model the regulatory role of proteins bound to looped DNA using a simulation in which dsDNA is represented as a self-avoiding chain, and proteins as spherical protrusions. We simulate long self-avoiding chains using a sequential importance sampling Monte-Carlo algorithm, and compute the probabilities for chain looping with and without a protrusion. We find that a protrusion near one of the chain’s termini reduces the probability of looping, even for chains much longer than the protrusion–chain-terminus distance. This effect increases with protrusion size, and decreases with protrusion-terminus distance. The reduced probability of looping can be explained via an eclipse-like model, which provides a novel inhibitory mechanism. We test the eclipse model on two possible transcription-factor occupancy states of the D. melanogaster eve 3/7 enhancer, and show that it provides a possible explanation for the experimentally-observed eve stripe 3 and 7 expression patterns. PMID:28085884
NASA Astrophysics Data System (ADS)
Jiang, Mu-Sheng; Sun, Shi-Hai; Tang, Guang-Zhao; Ma, Xiang-Chun; Li, Chun-Yan; Liang, Lin-Mei
2013-12-01
Thanks to the high-speed self-differencing single-photon detector (SD-SPD), the secret key rate of quantum key distribution (QKD), which can, in principle, offer unconditionally secure private communications between two users (Alice and Bob), can exceed 1 Mbit/s. However, the SD-SPD may contain loopholes, which can be exploited by an eavesdropper (Eve) to hack into the unconditional security of the high-speed QKD systems. In this paper, we analyze the fact that the SD-SPD can be remotely controlled by Eve in order to spy on full information without being discovered, then proof-of-principle experiments are demonstrated. Here, we point out that this loophole is introduced directly by the operating principle of the SD-SPD, thus, it cannot be removed, except for the fact that some active countermeasures are applied by the legitimate parties.
Schwamm, Christoph
2015-01-01
This article analyses the illness experiences of male patients from the Heidelberg University Psychiatric Hospital during the protests against Psychiatry in the year 1973. Protest is one of the most important expressions of masculinity in socially disadvantaged men, such as men with mental disorders. The analysis of 100 medical records shows that some patients tried to construct themselves as men in a way that was explicitly motivated by antipsychiatric ideas: They questioned psychiatric authority, behaved "sexually inappropriate", or used drugs. On the eve of psychiatric reform in West Germany those patients were well aware that the alternative--complying with the treatment--would put them at considerable risk. In addition to the usual inference of hegemonic or normative masculinities as risk-factors, the behavior of those ,,rebellious patients" has to be interpreted as individual coping strategies.
Endogenous hepadnaviruses, bornaviruses and circoviruses in snakes
Gilbert, C.; Meik, J. M.; Dashevsky, D.; Card, D. C.; Castoe, T. A.; Schaack, S.
2014-01-01
We report the discovery of endogenous viral elements (EVEs) from Hepadnaviridae, Bornaviridae and Circoviridae in the speckled rattlesnake, Crotalus mitchellii, the first viperid snake for which a draft whole genome sequence assembly is available. Analysis of the draft assembly reveals genome fragments from the three virus families were inserted into the genome of this snake over the past 50 Myr. Cross-species PCR screening of orthologous loci and computational scanning of the python and king cobra genomes reveals that circoviruses integrated most recently (within the last approx. 10 Myr), whereas bornaviruses and hepadnaviruses integrated at least approximately 13 and approximately 50 Ma, respectively. This is, to our knowledge, the first report of circo-, borna- and hepadnaviruses in snakes and the first characterization of non-retroviral EVEs in non-avian reptiles. Our study provides a window into the historical dynamics of viruses in these host lineages and shows that their evolution involved multiple host-switches between mammals and reptiles. PMID:25080342
Quantum key distribution using continuous-variable non-Gaussian states
NASA Astrophysics Data System (ADS)
Borelli, L. F. M.; Aguiar, L. S.; Roversi, J. A.; Vidiella-Barranco, A.
2016-02-01
In this work, we present a quantum key distribution protocol using continuous-variable non-Gaussian states, homodyne detection and post-selection. The employed signal states are the photon added then subtracted coherent states (PASCS) in which one photon is added and subsequently one photon is subtracted from the field. We analyze the performance of our protocol, compared with a coherent state-based protocol, for two different attacks that could be carried out by the eavesdropper (Eve). We calculate the secret key rate transmission in a lossy line for a superior channel (beam-splitter) attack, and we show that we may increase the secret key generation rate by using the non-Gaussian PASCS rather than coherent states. We also consider the simultaneous quadrature measurement (intercept-resend) attack, and we show that the efficiency of Eve's attack is substantially reduced if PASCS are used as signal states.
A surprise southern hemisphere meteor shower on New-Year's Eve 2015: the Volantids (IAU#758, VOL)
NASA Astrophysics Data System (ADS)
Jenniskens, P.; Baggaley, J.; Crumpton, I.; Aldous, P.; Gural, P. S.; Samuels, D.; Albers, J.; Soja, R.
2016-04-01
A new 32-camera CAMS network in New Zealand, spread over two stations on South Island, has detected a high southern declination shower that was active on New Year's Eve, 2015 December 31. During the observing interval from 09h12m - 15h45m UT, 21 out of 59 detected meteors radiated from the constellation of Volans, the flying fish, with a geocentric radiant at RA = 122.9 deg +- 4.7 deg, Dec = -71.9 deg +- 1.9 deg, and speed V_g = 28.4 +- 1.5 km/s. The new year arrived in New Zealand at 11h00m UT. Two more were detected the next night. No activity from this shower was observed the year prior. The meteoroids move in a 48 deg-inclined Jupiter-family comet orbit. The parent body has not yet been identified.
Monitoring of continuous-variable quantum key distribution system in real environment.
Liu, Weiqi; Peng, Jinye; Huang, Peng; Huang, Duan; Zeng, Guihua
2017-08-07
How to guarantee the practical security of continuous-variable quantum key distribution (CVQKD) system has been an important issue in the quantum cryptography applications. In contrast to the previous practical security strategies, which focus on the intercept-resend attack or the Gaussian attack, we investigate the practical security strategy based on a general attack, i.e., an arbitrated individual attack or collective attack on the system by Eve in this paper. The low bound of intensity disturbance of the local oscillator signal for eavesdropper successfully concealing herself is obtained, considering all noises can be used by Eve in the practical environment. Furthermore, we obtain an optimal monitoring condition for the practical CVQKD system so that legitimate communicators can monitor the general attack in real-time. As examples, practical security of two special systems, i.e., the Gaussian modulated coherent state CVQKD system and the middle-based CVQKD system, are investigated under the intercept-resend attacks.
Notes on a Continuous-Variable Quantum Key Distribution Scheme
NASA Astrophysics Data System (ADS)
Ichikawa, Tsubasa; Hirano, Takuya; Matsubara, Takuto; Ono, Motoharu; Namiki, Ryo
2017-09-01
We develop a physical model to describe the signal transmission for a continuous-variable quantum key distribution scheme and investigate its security against a couple of eavesdropping attacks assuming that the eavesdropper's power is partly restricted owing to today's technological limitations. We consider an eavesdropper performing quantum optical homodyne measurement on the signal obtained by a type of beamsplitting attack. We also consider the case in which the eavesdropper Eve is unable to access a quantum memory and she performs heterodyne measurement on her signal without performing a delayed measurement. Our formulation includes a model in which the receiver's loss and noise are unaccessible by the eavesdropper. This setup enables us to investigate the condition that Eve uses a practical fiber differently from the usual beamsplitting attack where she can deploy a lossless transmission channel. The secret key rates are calculated in both the direct and reverse reconciliation scenarios.
The mutagenicity of metallized and unmetallized azo and formazan dyes in the Salmonella mutagenicity
Laura. C. Edwards', Harold S. Freeman'*, and Larry D. Claxton2
Abstract
In previous papers, the synthesis and chemical properties of iron complexed azo and formazan d...
2014-03-01
Regression. 2nd ed. Hoboken, NJ: John Wiley & Sons, 2000. Lien, Dianna, Aline Quester, and Robert Shuford, Marine Corps Deployment Tempo and Retention...calhoun.nps.edu/public/bitstream/handle/10945/5778/11Mar_Lizarraga.pdf? sequence=1 Quester, Aline , Laura Kelley, Cathy Hiatt, and Robert Shoford. Marine
Storytime in a Digital World: Making a Case for Thinking Outside the Book
ERIC Educational Resources Information Center
Paganelli, Andrea
2016-01-01
Storytime is an important fixture in many school libraries that helps foster students' reading abilities. With a history of success, why would librarians want to alter storytime by incorporating technology? This article discusses how Laura Fleming, a long-time school librarian, addressed decreased student engagement in traditional reading…
Cultivating Inquiry-Driven Learners: A College Education for the Twenty-First Century
ERIC Educational Resources Information Center
Conrad, Clifton; Dunek, Laura
2012-01-01
Inquiry-driven learners anticipate, embrace, and adapt to disruptive change. Clifton Conrad and Laura Dunek advance a transformative purpose of a college education. They invite stakeholders from across higher education to engage in vigorous dialogue about the aims of a college education--and how to realize those aims. Increasingly influenced by…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-24
..., Financial Management Service, Financial Accounting and Services Division, Surety Bond Branch, 3700 East-West Highway, Room 6F01, Hyattsville, MD 20782. Dated: February 15, 2012. Laura Carrico, Director, Financial... Change and Change in State of Incorporation: Nations Bonding Company AGENCY: Financial Management Service...
ERIC Educational Resources Information Center
Lukes, Laura
2014-01-01
Because Laura Lukes used to be a geologist, when she started teaching science, she wanted to incorporate field experiences in her classroom. But, like many teachers, she faced obstacles: insufficient budgets, testing requirements, a lack of chaperones and transportation, and the safety concerns that come with fieldwork. As a result, a real field…
Sequential Art, the White House Conference, and School Library Media Specialists.
ERIC Educational Resources Information Center
Barron, Daniel D.
2002-01-01
Discusses sequential art, also known as comic books or graphic novels, as reading motivators, as content, as literature, and as the subject itself. Includes comic resources for school library media specialists and describes the White House Conference that Laura Bush has promoted that has given library media centers national visibility. (LRW)
ACHP | News | Mrs. Laura Bush Designates 61 New Preserve America
commitment to preserving an important part of our Nation's historic past for visitors, neighbors, and, most of the initiative include a greater shared knowledge about the Nation's past; strengthened regional tourism efforts, and eligibility for proposed Preserve America grants that will begin in Fiscal Year 2005
McConnell, Laura L., Jennifer A. Harman-Fetcho and James D. Hagy, III. 2004. Measured Concentrations of Herbicides and Model Predictions of Atrazine Fate in the Patuxent River Estuary. J. Environ. Qual. 33(2):594-604. (ERL,GB X1051).
The environmental fate of herbicides i...
Thirteen for Thirteen-Year-Olds
ERIC Educational Resources Information Center
Instructor, 2011
2011-01-01
What does it take to reach a middle school reader? Literacy expert Laura Robb recently shared her top strategies in a webcast for Scholastic fans. This article presents Robb's 13 strategies for thirteen-year-olds. These are: (1) Respect students' search for self; (2) Embrace blogging; (3) Send texts in class; (4) Take words apart; (5) Build…
Music Activities for "Mama", "Mama" and "Papa", "Papa"
ERIC Educational Resources Information Center
Cardany, Audrey Berger
2011-01-01
Jean Marzollo creates two beautiful texts using a child's first words, "Mama, Mama" and "Papa, Papa" as a recurring theme. Wildlife artist, Laura Regan, illustrates Marzollo's poetry with loving images of parents and children in the animal kingdom. Poetry and illustrations highlight the tenderness and care of Mama and Papa as they bond with their…
ACHP | News | Mrs. Laura Bush Designates 31 Preserve America Communities in
tourism for the state and its communities, and an effort headed by the State Historic Preservation Officer promotional materials; notification to media, State tourism offices, and visitor bureaus; and listing on a Web -based directory to showcase preservation efforts and highlight heritage tourism destinations. The Bush
ACHP | News | Mrs. Laura Bush Designates Corinth, Mississippi, a Preserve
; notification to media, state tourism offices, and visitor bureaus; and listing on a Web-based directory to showcase preservation efforts and highlight heritage tourism destinations. The Bush Administration's fiscal promotion of heritage tourism and other economic revitalization projects. John L. Nau, III, chairman of the
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-12
... docket (EDIS) at http://edis.usitc.gov . FOR FURTHER INFORMATION CONTACT: Project Leader Laura Rodriguez (202- 205-3499 or [email protected] ) for information specific to this investigation. For information on the legal aspects of this investigation, contact William Gearhart of the Commission's Office of...
Segmentation and Classification of Burn Color Images
2001-10-25
SEGMENTATION AND CLASSIFICATION OF BURN COLOR IMAGES Begoña Acha1, Carmen Serrano1, Laura Roa2 1Área de Teoría de la Señal y Comunicaciones ...2000, Las Vegas (USA), pp. 411-415. [21] G. Wyszecki and W.S. Stiles, Color Science: Concepts and Methods, Quantitative Data and Formulae (New
Where Daggers Are Only of the Mind
ERIC Educational Resources Information Center
Monaghan, Peter
2007-01-01
Laura Bates, an associate professor of English at Indiana State University, teaches college courses at Wabash Valley Correctional Facility, but her Shakespeare workshop is a rarer undertaking, with a startling history. About six years ago, an inmate in one of her college-degree courses was sent from the general population to the "SHU"--the…
Collaboration: A Reply to Bowern & Warner's Reply
ERIC Educational Resources Information Center
Robinson, Laura; Crippen, James
2015-01-01
Although Laura Robinson and James Crippen disagree strongly with a number of Bowern and Warner's [see EJ1075309] characterizations of their own paper ["In Defense of the Lone Wolf: Collaboration in Language Documentation" v7 p123-135 2013], Robinson and Crippen do agree with most of Bowern and Warner's assertions. In this reply, Robinson…
Working in the Virtual Stacks: The New Library and Information Science
ERIC Educational Resources Information Center
Kane, Laura Townsend, Ed.
2011-01-01
Thanks in part to technology, the boundaries of library positions are dissolving. It is no longer practical to discuss the profession in terms of traditional library types, and in today's library, the relationship between librarians and technology is stronger than ever. In this informative volume, veteran author Laura Townsend Kane interviews…
Must Public Education Restore Its Image as Great Equalizer?
ERIC Educational Resources Information Center
Carr, Nora
2006-01-01
Widely viewed today by many taxpayers, business leaders, and elected officials as inefficient, ineffective, bureaucratic, public education is losing its once-noble brand position as the cornerstone of American democracy. According to Laura Ries, a marketing guru, the first problem is the name, it is called public education. It is because the…
Combat Risk and Pay: Theory and Some Evidence
2011-10-01
Kavanagh, and Laura Miller. 2006. “How Deployments Affect Service Members.” RAND Report MG432. Hosek, James R. and Mark E. Totten . 2004. “The Effect of...Richard Layard, 12: 641 92. Amsterdam, Netherlands: North Holland Publishing Co. Shogren, Jason F. and Tommy Stamland. 2002. “Skill and the Value of
Child Discourse. Language, Thought, and Culture: Advances in the Study of Cognition.
ERIC Educational Resources Information Center
Ervin-Tripp, Susan, Ed.; Mitchell-Kernan, Claudia, Ed.
The following essays on children's spoken language are included in this volume: "Play with Language and Speech" by Catherin Garvey, "'You Fruithead': A Sociolinguistic Approach to Children's Dispute Settlement" by Donald Brenneis and Laura Lein, "From Verbal Play to Talk Story: The Role of Routines in Speech Events among…
Proceedings: Conference on the Community/Junior College (Knoxville, Tennessee, April 25-26, 1974).
ERIC Educational Resources Information Center
McCullough, K. Owen, Ed.
Presented at the 1974 Community/Junior College Conference, the papers in this monograph examine issues related to institutional, program, staff, and student evaluation. After K. Owen McCullough's and Earl M. Ramer's prefatory remarks, Laura Bornholdt presents a typology of negative staff attitudes toward program and institutional evaluations;…
ACHP | News | Mrs. Laura Bush Presents "Preserve America History Teacher
cases. However, regulatory and statutory changes since then have significantly altered case management practices. The Section 106 review process has evolved to focus ACHP participation on high-profile cases . Involvement in these cases can also lead the ACHP to pursue broad changes to Federal agency programs or
Harvard Education Letter. Volume 23, Number 2, March-April 2007
ERIC Educational Resources Information Center
Chauncey, Caroline, Ed.
2007-01-01
"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) More Than "Making Nice": Getting Teachers to (Truly) Collaborate (Laura Pappano); (2) "Doing the Critical Things First": An Aligned Approach to PreK and Early Elementary Math;…
Implementing No Child Left Behind in Three States. Research Brief
ERIC Educational Resources Information Center
Stecher, Brian M.; Epstein, Scott; Hamilton, Laura S.; Marsh, Julie A.; Robyn, Abby; McCombs, Jennifer Sloan; Russell, Jennifer; Naftel, Scott
2008-01-01
This research brief describes work done for RAND Education and documented in "Pain and Gain: Implementing No Child Left Behind in Three States, 2004-2006", Brian M. Stecher, Scott Epstein, Laura S. Hamilton, Julie A. Marsh, Abby Robyn, Jennifer Sloan McCombs, Jennifer Russell, and Scott Naftel." The three states discussed are:…
Histories of Special Education: Stories from Our Past, Insights for Our Future.
ERIC Educational Resources Information Center
Smith, J. David
1998-01-01
Discusses the contributions of historical research to special education and describes the research by Margaret Mead, the views of Helen Keller, and Laura Bridgman, and the work of Samuel Gridley Howe. The importance of understanding aspects of people and events that have previously been overlooked is emphasized. (CR)
NASA Astrophysics Data System (ADS)
Qin, Hao; Kumar, Rupesh; Alleaume, Romain
2015-10-01
We report here a new side channel attack on a practical continuous-variable (CV) quantum key distribution (QKD) system. Inspired by blinding attack in discrete-variable QKD, we formalize an attack strategy by inserting an external light into a CV QKD system implemented Gaussian-modulated coherent state protocol and show that our attack can compromise its practical security. In this attack, we concern imperfections of a balanced homodyne detector used in CV QKD. According to our analysis, if one inserts an external light into Bob's signal port, due to the imperfect subtraction from the homodyne detector, the leakage of the external light contributes a displacement on the homodyne signal which causes detector electronics saturation. In consequence, Bob's quadrature measurement is not linear with the quadrature sent by Alice. By considering such vulnerability, a potential Eve can launch a full intercept-resend attack meanwhile she inserts an external light into Bob's signal port. By selecting proper properties of the external light, Eve actively controls the induced displacement value from the inserted light which results saturation of homodyne detection. In consequence, Eve can bias the excess noise due to the intercept-resend attack and the external light, such that Alice and Bob believe their excess noise estimation is below the null key threshold and they can still share a secret key. Our attack shows that the detector loopholes also exist in CV QKD, and it seems influence all the CV QKD systems using homodyne detection, since all the practical detectors have finite detection range.
NASA Astrophysics Data System (ADS)
Boustead, Barbara E.
The Hard Winter of 1880-1881 was featured in the Laura Ingalls Wilder historical fiction account, The Long Winter, as well as in several town histories across the region. Both meteorological records and historical accounts indicate that the winter was particularly long, snowy, and cold. The question of how "hard" a winter is for a given location depends on the climatological context, which relies on an objective characterization of winter severity. The Accumulated Winter Season Severity Index (AWSSI) allows comparison of the winter of 1880-1881 among sites across the region, as well as in the context of the period of record, to quantify its severity. Additionally, investigating the impacts of both the El Nino/Southern Oscillation (ENSO) and the North Atlantic Oscillation (NAO) in the central United States provides context for the influence of both a strongly negative NAO and an El Nino event during the winter of 1880-1881. With an understanding of the climatological factors influencing the Hard Winter, along with the context for its severity, a more thorough analysis then was conducted to quantify and describe its severity. The connection of the winter of 1880-1881 to a popular book written by an author who is a cultural icon provides a natural vehicle with which to communicate weather and climate concepts to multiple non-technical audiences. The communication of complex weather and climate concepts is a well-documented challenge. One method to bridge between science concepts and public understanding is to relate those concepts to familiar subjects and stories, including Laura Ingalls Wilder's books. A narrative constructed around the books, particularly The Long Winter, provides a means of audience engagement and interest in weather- and climate-related topics, which was at least partially quantified by surveying audiences of the narrative. Overall, the scientific background, combined with a familiar narrative voice, provides a means to transmit weather and climate.
Mars Orbiter Sees Rover Opportunity at Crater Edge
2011-01-04
NASA Mars Reconnaissance Orbiter acquired this image of the Opportunity rover on the southwest rim of Santa Maria crater on New Year Eve 2010. Opportunity is imaging the crater interior to better reveal the geometry of rock layers.
ERIC Educational Resources Information Center
Pellowski, Ann
1979-01-01
Discusses the universality of children's literature and advocates the publication and reading of children's literature from other countries, particularly non-Western countries, in the United States. (CMV)
Wilson on the AFD during STS-121
2006-07-05
S121-E-05438 (5 July 2006) --- Astronaut Stephanie D. Wilson, STS-121 mission specialist, on Discovery's flight deck during flight day two activities, on the eve of one of the mission's busiest days -- docking day with the International Space Station.
25. Historic American Buildings Survey, Stevens Commercial Photographers, December 31, ...
25. Historic American Buildings Survey, Stevens Commercial Photographers, December 31, 1927 Photocopy by Lyle E. Winkle, 1969 WEATHERLY BUILDING AND ORIENTAL THEATRE, LOOKING SOUTHEAST (TAKEN EVE OF THEATRE OPENING). - Oriental Theatre, 828 Southeast Grand Avenue, Portland, Multnomah County, OR
ERIC Educational Resources Information Center
Walsh, William M.; Keenan, Robert
1997-01-01
States that narrative family therapy is informed by social constructionism and postmodern worldviews, and is a relatively significant departure from mainstream psychotherapy. Discusses the use of narrative family therapy. Uses the story of Adam and Eve in the Garden of Eden as an example. (MKA)
Spring Research Festival and NICBR Collaboration Winners Announced | Poster
By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria
"Why Do They Hate Us?": Leading amid Criticism, Crisis, and Disrespect
ERIC Educational Resources Information Center
Karpinski, Carol F.
2012-01-01
Laura Dannon, an educator with experience as teacher, assistant principal, and principal, enjoys her profession. Faculty camaraderie and student/teacher busyness at her school have led her to think all is well. A sudden outburst by a new teacher causes her to reflect on what is really happening. What has changed? Have media criticism, movements…
ERIC Educational Resources Information Center
Garnett, Donald T., Ed.
This report of a conference on developmental advising contains the following 18 papers: "An Introduction to the Myers-Briggs Type Indicator (MBTI)" (Roberta Corder); "Computer-Assisted Advising: The Personal Touch" (Susan Aldrich, Mark Peterson, Bruce Sands); "The Freshman Survey: Phase I" (Laura Lemonine);…
Phone CCI Jonathan Lewis Manager jdl@fnal.gov 1-630-840-3779 GEM Sandra Charles Manager scharles gdzurics@fnal.gov 1-630-687-2929 SIST Sandra Charles Manager sist@fnal.gov 1-630-840-4574 Laura Fields Committee Chair sist@fnal.gov 1-630-840-8491 TARGET Sandra Charles Manager scharles@fnal.gov 1-630-840-4574
Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-24
... interested in the public's experience, input, and estimates on the burden in terms of time and money incurred....regulations.gov . We may also be contacted at: USCIS, Office of Policy and Strategy, Regulatory Coordination... 21, 2013. Laura Dawkins, Chief, Regulatory Coordination Division, Office of Policy and Strategy, U.S...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-09
... site. The URL for this survey site will also be advertised separately through media and social media... information on the proposed project, contact: Laura M. Koehly, Ph.D., Senior Investigator, Social and... in health conditions and associated risk factors; The role of friends, family, media, and health...
The White House Conference on School Libraries Proceedings (Washington, DC, June 4, 2002).
ERIC Educational Resources Information Center
Institute of Museum and Library Services, Washington, DC.
Laura Bush hosted a White House Conference on School Libraries on June 4, 2002, to discuss the latest research on libraries, student achievement and successful local programs. Mrs. Bush's cohost was Dr. Robert Martin, Director of the Institute of Museum and Library Services and education, library, government and philanthropic leaders from across…
Looking at Citizenship through a Literary Lens
ERIC Educational Resources Information Center
Tavares, Laura
2017-01-01
President Barack Obama once said he believes that he learned how to be a good citizen by reading novels. In this article, Laura Tavares looks at the ways that ELA teachers can use fiction to illustrate social and ethical awareness, humility, and a tolerance for difference--all traits that are necessary to be a good citizen. By putting themselves…
2010-04-01
Rubrics for the ASBMB Undergraduate Poster Competition 2007 Dr. David Usher (Dept. of Biological Sciences), Tyler Larsen and Laura Sloofman. A good site...did his research on a genetic disease called Spinal Muscular Atrophy, also known as SMA. "I did research up at the Children’s Hospital because this is a
ERIC Educational Resources Information Center
University of West Florida, Pensacola.
The following papers are included: "Concepts on Marketing Issues in the Czech Republic" (Anne Mills); "Requiring More of Teacher Preparation: Authentic Assessment as a Vehicle to Reform" (Laura J. Wyant); "A Delphi Study of Professional Competencies for the Secondary Marketing Educator" (Trellys A. Morris); "The…
Trust-Based Design of Human-Guided Algorithms
2007-06-01
Management Interdepartmental Program in Operations Research 17 May, 2007 Approved by: Laura Major Forest The Charles Stark Draper Laboratory...2. Information Analysis: predicting based on data, integrating and managing information, augmenting human operator perception and cognition. 3...allocation of automation by designers and managers . How an operator decides between manual and automatic control of a system is a necessary
ACHP | News | Laura Bush Announces Preserve America Grants Budget
, Kentucky. In addition, Mrs. Bush announced two new education efforts to enhance the teaching of history in America's classrooms: Preserve America has worked with the History Channel's Save Our History initiative to support the creation of a history education manual. This manual provides teachers with lesson plans and
ACHP | News | First Lady Laura Bush Launches Preserve America Initiative
historic architecture, landscapes and communities. Every one tells a story about the past and provides will be one of many opportunities for learning and recreation. In Idaho, modern-day explorers can Salmon and Lemhi Valleys is one of the few original portions still in existence. Visitors can see
Doing Social Media So It Matters: A Librarian's Guide
ERIC Educational Resources Information Center
Solomon, Laura
2010-01-01
Facebook, Twitter, MySpace, LinkedIn: it's difficult enough to keep abreast of social media Web sites, let alone understand how they fit into today's library. This practical resource brings together current information on the topic in a concise format that's easy to digest. Laura Solomon is a librarian with more than a decade of experience in Web…
Rescuing the Soiled Dove: Pop Culture's Influence on a Historical Narrative of Prostitution
ERIC Educational Resources Information Center
Voelkel, Micki; Henehan, Shelli
2018-01-01
American popular culture romanticises relationships between sex workers and their customers; novels, films and television depict prostitutes as innocents in need of rescue by a wealthy or powerful man. Miss Laura's Social Club, a restored Victorian brothel in Fort Smith, Arkansas, USA, functions both as an informal house museum and the visitor…
ERIC Educational Resources Information Center
Weiner, Jennie Miles; Burton, Laura J.
2016-01-01
In this study of nine participants in a turnaround principal preparation program, Jennie Miles Weiner and Laura J. Burton explore how gender role identity shaped participants' views of effective principal leadership and their place within it. The authors find that although female and male participants initially framed effective leadership…
Creation of a California Tribe: Grandfather's Maidu Indian Tales.
ERIC Educational Resources Information Center
Smith-Trafzer, Lee Ann; Trafzer, Clifford E.
This children's book relates the story of Travis and Laura and how their grandfather, a Maidu Indian, teaches them about their history and culture through stories. The book stresses the importance of storytelling as the traditional way of passing on the history of Indian peoples. As part of a school project, Travis tells his classmates the Maidu…
Elizabeth Dennis Baldwin; Laura S. Kenefic; Will F. LaPage
2007-01-01
Based on confidential interviews with 21 decision leaders in Maine, Elizabeth Baldwin, Laura Kenefic, and Will LaPage examine the complexity of the conflicts over alternate visions for large-scale conservation in Maine. Exploring models that may be useful for policymakers grappling with competing values for Maine's forests, they present four alternatives: national...
Establishing Sustainable Higher Education Partnerships in a Globally Competitive Environment
ERIC Educational Resources Information Center
Chigisheva, Oksana
2013-01-01
The paper written in the form of literature review is devoted to the analysis of the latest educational manuscripts by Laura M. Portnoi et al and Robin Sakamoto et al and provides a critical overview of possible partnership interactions in the actively globalizing sphere of world higher education. [For complete volume, see ED567118.
Dynamic Models of Insurgent Activity
2014-05-19
Martin Short, P. Jeffrey Brantingham, Frederick Schoenberg, George Tita . Self-Exciting Point Process Modeling of Crime, Journal of the American...Mohler, P. J. Brantingham, G. E. Tita . Gang rivalry dynamics via coupled point process networks, Discrete and Continuous Dynamical Systems - Series...8532-2-1 Laura Smith, Andrea Bertozzi, P. Jeffrey Brantingham, George Tita , Matthew Valasik. ADAPTATION OF AN ECOLOGICAL TERRITORIAL MODEL TOSTREET
ERIC Educational Resources Information Center
Keddie, Amanda
2009-01-01
This paper presents the philosophies and practices of "Laura", a young English community liaison worker and former religious studies teacher who has recently converted to Islam. Drawing on data generated from a qualitative and predominantly interview-based research project that investigated issues of pedagogy and social justice in…
Carpenter, Jordan; Crutchley, Patrick; Zilca, Ran D; Schwartz, H Andrew; Smith, Laura K; Cobb, Angela M; Parks, Acacia C
2017-12-19
[This corrects the article DOI: 10.2196/jmir.5725.]. ©Jordan Carpenter, Patrick Crutchley, Ran D Zilca, H Andrew Schwartz, Laura K Smith, Angela M Cobb, Acacia C Parks. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.12.2017.
ERIC Educational Resources Information Center
Tierney, William G., Ed.; Hagedorn, Linda Serra, Ed.
This collection of papers examines pre-college enrichment programs that offer a specific remedy to the problem of low income and underrepresented students' access to higher education. The 10 papers are: (1) "Pre-College Outreach Programs: A National Perspective" (Watson Scott Swail and Laura W. Perna); (2) "The Relationship between…
"Butterfly under a Pin": An Emergent Teacher Image amid Mandated Curriculum Reform
ERIC Educational Resources Information Center
Craig, Cheryl J.
2012-01-01
The author examines 1 experienced teacher's image of teaching and how it was purposely changed--through external intervention and against the individual's will--from the view of teacher as curriculum maker to the view of teacher as curriculum implementer. Laura's account of the "butterfly under a pin" image, a version of the…
2013-08-01
meeting was held on April 14, 2013. The members of the DSMB included Dr. Sunil Bhar (Swinburne University), Dr. Walter Matweychuk (University of...Depression (NARSAD) Study Representatives: Dr. Marjan Holloway (PI); Dr. Laura Neely (Clinical Coordinator) DSMB Members: Dr. Sunil Bhar
Technology for Musicianship: Using the Internet for Music Instruction.
ERIC Educational Resources Information Center
Kassner, Kirk
2001-01-01
Presents descriptions of using the Internet for music instruction by Laura Ferguson, James F. Daugherty, and Sandi MacLeod. Covers topics such as steps for creating and publishing movies on a Web site, a template for electronic learning called ChoirONLINE based on the creative use of interactive Web forms, and the Vermont MIDI Project. (CMK)
ERIC Educational Resources Information Center
Institute of International Education, New York, NY.
This document features writings and curriculum projects by teachers who traveled to Mexico and Central America in the summer of 1991 as members of a Fulbright-Hays Summer Seminar. The following items are among the 20 included: Curriculum Project: "'Escritoras Mexicanas Contemporaneas': A Survey of Mexican Women Fiction Writers" (Laura J.…
INHIBITION OF TOBACCO SMOKE-INDUCED LUNG INFLAMMATION BY A CATALYTIC ANTIOXIDANT
AMathematical Model for the Kinetics of the Male Reproductive Endocrine System
Laura K. Potter1,2, H.A. Barton2 and R.W. Setzer2
1Curriculum in Toxicology, UNC-Chapel Hill, NC; 2US EPA, ORD, NHEERL, ETD, RTP, NC
In this presentation a model for the hormonal regul...
Harvard Education Letter. Volume 23, Number 4, July-August 2007
ERIC Educational Resources Information Center
Chauncey, Caroline, Ed.
2007-01-01
"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Meeting of the Minds: The Parent-Teacher Conference Is the Cornerstone of School-Home Relations. How Can It Work for All Families? (Laura Pappano); (2) In Search of That "Third…
Providing a Global Education for Refugee Students: An Activity about Personal Budgeting
ERIC Educational Resources Information Center
Quaynor, Laura J.; Hamilton, Carrie
2012-01-01
In this article, the authors describe how a teacher (Carrie Hamilton) can scaffold and connect social studies concepts to a variety of students' experiences in meaningful ways. They draw on findings from Laura J. Quaynor's study about social studies education for immigrant students who are also refugees. Together, they discuss effective pedagogic…
Formation of Verbal Behavior of Deaf-Blind Children.
ERIC Educational Resources Information Center
Umezu, Hachizo
The monograph describes the development of verbal behavior over a 20-year period in two deaf Japanese children (5- and 7-years-old when first contacted by the author) with whom previous training attempts had failed. It is noted that prior training methods which had succeeded with Laura Bridgman and Helen Keller failed with these two children. A…
Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-10
.... Lover's Lane & Co., 46750 Port St., Plymouth, MI 48170-6031. PHE, Inc. d/b/a Adam & Eve, 302 Meadowland.... Mile Inc. d/b/a Lion's Den Adult, 110 East Wilson Bridge Road, Suite 110, Worthington, OH 43085...
Prazak, Lisa; Fujioka, Miki; Gergen, J. Peter
2010-01-01
The relatively simple combinatorial rules responsible for establishing the initial metameric expression of sloppy-paired-1 (slp1) in the Drosophila blastoderm embryo make this system an attractive model for investigating the mechanism of regulation by pair rule transcription factors. This investigation of slp1 cis-regulatory architecture identifies two distinct elements, a proximal early stripe element (PESE) and a distal early stripe element (DESE) located from −3.1 kb to −2.5 kb and from −8.1 kb to −7.1 kb upstream of the slp1 promoter, respectively, that mediate this early regulation. The proximal element expresses only even-numbered stripes and mediates repression by Even-skipped (Eve) as well as by the combination of Runt and Fushi-tarazu (Ftz). A 272 basepair sub-element of PESE retains Eve-dependent repression, but is expressed throughout the even-numbered parasegments due to the loss of repression by Runt and Ftz. In contrast, the distal element expresses both odd and even-numbered stripes and also drives inappropriate expression in the anterior half of the odd-numbered parasegments due to an inability to respond to repression by Eve. Importantly, a composite reporter gene containing both early stripe elements recapitulates pair-rule gene-dependent regulation in a manner beyond what is expected from combining their individual patterns. These results indicate interactions involving distinct cis-elements contribute to the proper integration of pair-rule regulatory information. A model fully accounting for these results proposes that metameric slp1 expression is achieved through the Runt-dependent regulation of interactions between these two pair-rule response elements and the slp1 promoter. PMID:20435028
Zaza, Gianluigi; Dalla Gassa, Alessandra; Felis, Giovanna; Granata, Simona; Torriani, Sandra; Lupo, Antonio
2017-01-01
The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined. We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols. Nine patients were treated with everolimus plus mycophenolate mofetil (EVE+MMF group), and 11 patients were treated with a standard therapy with tacrolimus plus mycophenolate mofetil (TAC+MMF group). A statistical analysis of comparative high-throughput data demonstrated that although similar according to the degree of Shannon diversity (alpha diversity) at the taxonomic level, three functional genes clearly discriminated EVE+MMF versus TAC+MMF (cutoff: log2 fold change≥1, FDR≤0.05). Flagellar motor switch protein (fliNY) and type IV pilus assembly protein pilM (pilM) were significantly enriched in TAC+MMF-treated patients, while macrolide transport system mrsA (msrA) was more abundant in patients treated with EVE+MMF. Finally, PERMANOVA revealed that among the variables analyzed and included in our model, only the consumption of sugar significantly influenced beta diversity. Our study, although performed on a relatively small number of patients, showed, for the first time, specific immunosuppressive-related effects on fecal microbiome of renal transplant recipients and it suggested that the analysis of the gut microbes community could represent a new tool to better understand the effects of drugs currently employed in organ transplantations. However, multicenter studies including healthy controls should be undertaken to better address this objective.
Multimode entanglement assisted QKD through a free-space maritime channel
NASA Astrophysics Data System (ADS)
Gariano, John; Djordjevic, Ivan B.
2017-10-01
When using quantum key distribution (QKD), one of the trade-offs for security is that the generation rate of a secret key is typically very low. Recent works have shown that using a weak coherent source allows for higher secret key generation rates compared to an entangled photon source, when a channel with low loss is considered. In most cases, the system that is being studied is over a fiber-optic communication channel. Here a theoretical QKD system using the BB92 protocol and entangled photons over a free-space maritime channel with multiple spatial modes is presented. The entangled photons are generated from a spontaneous parametric down conversion (SPDC) source of type II. To employ multiple spatial modes, the transmit apparatus will contain multiple SPDC sources, all driven by the pump lasers assumed to have the same intensity. The receive apparatuses will contain avalanche photo diodes (APD), modeled based on the NuCrypt CPDS-1000 detector, and located at the focal point of the receive aperture lens. The transmitter is assumed to be located at Alice and Bob will be located 30 km away, implying no channel crosstalk will be introduced in the measurements at Alice's side due to turbulence. To help mitigate the effects of atmospheric turbulence, adaptive optics will be considered at the transmitter and the receiver. An eavesdropper, Eve, is located 15 km from Alice and has no control over the devices at Alice or Bob. Eve is performing the intercept resend attack and listening to the communication over the public channel. Additionally, it is assumed that Eve can correct any aberrations caused by the atmospheric turbulence to determine which source the photon was transmitted from. One, four and nine spatial modes are considered with and without applying adaptive optics and compared to one another.
ERIC Educational Resources Information Center
Kansas State Univ., Manhattan. Center for Rural Education and Small Schools.
This proceedings contains abstracts of 21 presentations. Titles and presenters are: "Teaching and Learning in Multiage Classrooms" (Laura Blevins and others); "Leadership, School Reform and the Rural School Superintendent" (Mike Boone); "Teaching English as a Second Language from Theory to Practice" (Mingsheng Dai); "A Guide for Central Office…
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-07
... submitted the following information collection request to the Office of Management and Budget (OMB) for... Benefit DATES: Submit comments to the Office of Management and Budget (OMB) for up to 30 days from July 7... and Regulatory Affairs at the Office of Management and Budget (OMB). You may submit comments by the...
1993-09-01
AF89-071. Washington: GPO, 1989. 159 14. Diaz , SSgt Laura, 648 Med Sq/SGHL. Personal interview. Brooks AFB, San Antonio TX, 14 July 1993. 15. EA...Training Strateav of the Acauisition Management of Hazardous Materials Program. Draft Report. McLean VA, August 1991. 36. Moore, SSgt Alicia . AL/OEVP
Advice for Fund Raisers: Know Your Donors and Never Let Them See You Sweat
ERIC Educational Resources Information Center
Masterson, Kathryn
2008-01-01
The psychology behind getting the big gift and making "the ask" for it was a major topic at Fund Raising Day in New York 2008, which drew representatives from across the nonprofit world, including charities, hospitals, colleges, and museums. Laura Fredricks, who was vice president for philanthropy at Pace University from 2002 until earlier this…
World War II Activity Day: Through the Eyes of Trainee Treachers
ERIC Educational Resources Information Center
Clark, Emily; Hornsby, Laura; Howard, Abigail; Pople, Kathryn
2013-01-01
As student teachers, authors Emily Clark, Laura Hornsby, Abigail Howard, and Kathryn Pople were aware of what the class had already covered on World War 2 (WW2). It was unclear to them, however, what knowledge the children actually had acquired from the lessons. In this article these student teachers describe their use of concept mapping as they…
ERIC Educational Resources Information Center
Koch, Richard; Roop, Laura; Setter, Gail
2006-01-01
The National Writing Project at Work (NWP) monograph series documents how the National Writing Project model is implemented and developed at local sites across the country. These monographs describe NWP work, which is often shared informally or in workshops. Richard Koch and Laura Roop present a model of standards-based professional development…
ERIC Educational Resources Information Center
Hein, Laura, Ed.; Selden, Mark, Ed.
This collection of essays focuses on textbook treatments of World War II in Japan, Germany, and the United States and gives readers a new perspective on the creation of national identities and international misunderstandings. Essays in the collection are: (1) "The Lessons of War, Global Power, and Social Change" (Laura Hein; Mark…
Unequal Fortunes: Snapshots from the South Bronx
ERIC Educational Resources Information Center
Levine, Arthur; Scheiber, Laura
2010-01-01
In this powerful book, Arthur Levine (president of the Woodrow Wilson Foundation) and coauthor Laura Scheiber revisit the South Bronx, where Levine grew up in the 1960s, and compare his experiences with those of a group of teenagers coming of age in the same neighborhood nearly 40 years later. Shaken by the violent death of Leo Disla, one of the…
ERIC Educational Resources Information Center
Consortium on Financing Higher Education, Cambridge, MA.
Proceedings of a 1980 Brown University conference on faculty retirement are presented. Papers and authors are as follows: "A Review of Current Legal Status and National Policy Issues" (Laura C. Ford); "Mandatory Retirement Age Legislation for Tenured Faculty: The Policy Issues and Their Context" (W. Lee Hansen);…
Meteor Beliefs Project: ``Year of Meteors''
NASA Astrophysics Data System (ADS)
McBeath, Alastair; Drobnock, George J.; Gheorghe, Andrei Dorian
2011-10-01
We present a discussion linking ideas from a modern music album by Laura Veirs back to a turbulent time in American history 150 years ago, which inspired poet Walt Whitman to compose his poem "Year of Meteors", and the meteor beliefs of the period around 1859-1860, when collection of facts was giving way to analyses and theoretical explanations in meteor science.
Volunteer Flying Organizations: Law Enforcements Untapped Resource
2016-12-01
ORGANIZATIONS: LAW ENFORCEMENT’S UNTAPPED RESOURCE by Christopher R. Laird December 2016 Thesis Advisor: Erik Dahl Second Reader: Laura...DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE VOLUNTEER FLYING ORGANIZATIONS: LAW ENFORCEMENT’S UNTAPPED RESOURCE 5. FUNDING NUMBERS 6...is unlimited. 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Given the fiscal constraints of today’s law enforcement environment
ERIC Educational Resources Information Center
Russell, Michele, Ed.
Papers on aspects of college admission, records, and institutional research functions are: "How To Improve Office Morale" (Victor Swenson); "Staff Meetings: How To Save Hours per Month and Develop Your Staff" (LuAnn Harris, Shelley Olsen); "Selling SPEED/ExPRESS" (Laura Patterson, Thomas Scott); "Advisement and…
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-05
... accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended...: Laura K. Moen, Ph.D., Director, Division of Extramural Research Activities, NIAMS/NIH, 6700 Democracy... show one form of identification (for example, a government-issued photo ID, driver's license, or...
Survivors on Campus: A Dialogue about Sexual Assault
ERIC Educational Resources Information Center
Gray-Rosendale, Laura; Dierking, Kirsten
2014-01-01
At a conference last fall, Kirsten Dierking came across "College Girl: A Memoir," a book by Laura Gray-Rosendale that tells the story of a brutal sexual assault she experienced as a college student. While she purchased a copy of the book, it sat unopened on her desk for a while; also a victim of brutal rape in college, she was not sure…
ERIC Educational Resources Information Center
Ireland, Ruby
2009-01-01
Edouard Lock's dance film "Amelia" (2002) is the focus of this essay. Second-wave feminist and poststructuralist perspectives inform the analysis of this piece of contemporary dance. Laura Mulvey's male gaze theory and Julia Kristeva's theory of the semiotic and symbolic realms of representation are explored and critiqued, whilst Jacques Derrida's…
Assessing 21st Century Skills: A Guide to Evaluating Mastery and Authentic Learning
ERIC Educational Resources Information Center
Greenstein, Laura
2012-01-01
The Common Core State Standards clearly define the skills students need for success in college and the 21st century workplace. The question is, how can you measure student mastery of skills like creativity, problem solving, and use of technology? Laura Greenstein demonstrates how teachers can teach and assess 21st century skills using authentic…
From Laura Ingalls to Wing Biddlebaum: A Study of Teacher Identity in Works of Literature
ERIC Educational Resources Information Center
Muchmore, James A.
2010-01-01
The purpose of this study is to systemically analyze the types of teachers that appear in works of literature, and to explore the various teacher identities that are depicted. The data consists of 44 works of literature representing a wide variety of genres, settings, cultures, and historical periods. They include 20 adult novels, 6 young adult…
ERIC Educational Resources Information Center
Roy, Laura A.; Roxas, Kevin C.
2011-01-01
In this article, Laura Roy and Kevin Roxas draw from two studies with Somali Bantu refugee families in South Texas and Michigan. Findings from both study sites revealed a disconnect between how educators perceived the Somali Bantu families' educational goals and Somali Bantu families' actual views of education. In contrast to educators'…
ERIC Educational Resources Information Center
Currie, Laura-Ann; Prudnikova, Victoria; Yarkova, Natalya
2005-01-01
In this article, Laura Ann Currie and Victoria Prudnikova describe a three-year Russian/Scottish partnership designed to take forward an inclusive educational policy in the Samara Region of Russia. Education staff from West Lothian Council and Barnardo's visited the Samara Region to train staff there to help take forward their inclusion programme.…
Phytoremediation of Hazardous Wastes
1995-07-26
TITLE AND SUBTITLE Phytoremediation of Hazardous Wastes 6. AUTHOR(S) Steven C. McCutcheon, N. Lee Wolfe, Laura H. Carreria and Tse-Yuan Ou 5... phytoremediation (the use of plants to degrade hazardous contaminants) was developed. The new approach to phytoremediation involves rigorous pathway analyses...SUBJECT TERMS phytoremediation , nitroreductase, laccase enzymes, SERDP 15. NUMBER OF PAGES 8 16. PRICE CODE N/A 17. SECURITY CLASSIFICATION OF
Sedimentary facies and Holocene depositional processes of Laura Island, Majuro Atoll
NASA Astrophysics Data System (ADS)
Yasukochi, Toru; Kayanne, Hajime; Yamaguchi, Toru; Yamano, Hiroya
2014-10-01
The depositional processes that formed Laura Island, Majuro Atoll, Marshall Islands, were reconstructed based on a facies analysis of island sediments and spine ratios, and radiocarbon ages of foraminifera. Sedimentary facies were analyzed from trenches and drill cores excavated on the island and its adjacent reef flat. Depositional ages were obtained using benthic foraminifera (Calcarina) whose spines had not been abraded. The facies were classified into two types: gravelly and sandy. The initial sediments of these sites consisted of gravelly facies in the lower horizon and sandy facies in the upper horizon. Their ages were approximately 2000 cal BP and coincident with the onset of a 1.1-m decline in regional relative sea level, which enabled deposition of the gravelly facies. Half of the sand fraction of the sediment was composed of larger benthic foraminifera. The spine ratio showed that their supply source on the reef flat was located oceanside of the island. The supply source appears to have been caused by the relative sea-level fall. This indicates that the studied island was formed by a relative reduction in wave energy and enhanced foraminiferal supply, both of which were triggered by the late Holocene relative sea-level fall.
Acaba and Swanson in US Laboratory Destiny
2009-03-20
S119-E-006743 (20 March 2009) --- On the eve of a planned shared spacewalk, astronauts Steve Swanson (left) and Joseph Acaba, both STS-119 mission specialists, have a meeting in the Joint Airlock aboard the International Space Station, while linked to the Space Shuttle Discovery.
2008-06-07
S124-E-007652 (7 June 2008) --- Astronauts Mike Fossum (foreground) and Ron Garan, both mission specialists, are busy in the Harmony node on the eve of STS-124's third and final session of extravehicular activity (EVA) to perform work on the International Space Station.
Traffic safety facts 1999 : children
DOT National Transportation Integrated Search
2000-01-01
In 1999, there were more than 58 million children under 15 years old in the United States. This age group (0-14 years) made up 21% of the total U.S. resident population in 1999. Motor vehicle crashes are the leading cause of death for children of eve...
U.S. EPA, Pesticide Product Label, BONIDE EVERGREEN-FLOWER INSECT SPRAY, 09/27/1988
2011-04-13
... " bel~eved, to be' rella,?le .;' The buyer ,'Ilust aR ... or WlfHl -)S,,<'I:,' -'i~' ' ,,unde,r,:llbnor'll,al 'Ccind~~i,~ns not rC"!Jon;llil'y forese,coble t! .. ~:lc ~;~~! ...
ERIC Educational Resources Information Center
Hantula, James
1979-01-01
Describes two ways of teaching mythology in the secondary school social studies classroom: myth as a cultural concept and myth as a fallacy. The first way provides students with an understanding of the concept of culture; the second, an opportunity to develop skills in critical thinking. (Author/KC)
Effect of source tampering in the security of quantum cryptography
NASA Astrophysics Data System (ADS)
Sun, Shi-Hai; Xu, Feihu; Jiang, Mu-Sheng; Ma, Xiang-Chun; Lo, Hoi-Kwong; Liang, Lin-Mei
2015-08-01
The security of source has become an increasingly important issue in quantum cryptography. Based on the framework of measurement-device-independent quantum key distribution (MDI-QKD), the source becomes the only region exploitable by a potential eavesdropper (Eve). Phase randomization is a cornerstone assumption in most discrete-variable (DV) quantum communication protocols (e.g., QKD, quantum coin tossing, weak-coherent-state blind quantum computing, and so on), and the violation of such an assumption is thus fatal to the security of those protocols. In this paper, we show a simple quantum hacking strategy, with commercial and homemade pulsed lasers, by Eve that allows her to actively tamper with the source and violate such an assumption, without leaving a trace afterwards. Furthermore, our attack may also be valid for continuous-variable (CV) QKD, which is another main class of QKD protocol, since, excepting the phase random assumption, other parameters (e.g., intensity) could also be changed, which directly determine the security of CV-QKD.
Event Display for the Visualization of CMS Events
NASA Astrophysics Data System (ADS)
Bauerdick, L. A. T.; Eulisse, G.; Jones, C. D.; Kovalskyi, D.; McCauley, T.; Mrak Tadel, A.; Muelmenstaedt, J.; Osborne, I.; Tadel, M.; Tu, Y.; Yagil, A.
2011-12-01
During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.
Solar Flare Impulsive Phase Observations from SDO and Other Observatories
NASA Technical Reports Server (NTRS)
Chamberlin, Phillip C.; Woods, Thomas N.; Schrijver, Karel; Warren, Harry; Milligan, Ryan; Christe, Steven; Brosius, Jeffrey W.
2010-01-01
With the start of normal operations of the Solar Dynamics Observatory in May 2010, the Extreme ultraviolet Variability Experiment (EVE) and the Atmospheric Imaging Assembly (AIA) have been returning the most accurate solar XUV and EUV measurements every 10 and 12 seconds, respectively, at almost 100% duty cycle. The focus of the presentation will be the solar flare impulsive phase observations provided by EVE and AIA and what these observations can tell us about the evolution of the initial phase of solar flares. Also emphasized throughout is how simultaneous observations with other instruments, such as RHESSI, SOHO-CDS, and HINODE-EIS, will help provide a more complete characterization of the solar flares and the evolution and energetics during the impulsive phase. These co-temporal observations from the other solar instruments can provide information such as extending the high temperature range spectra and images beyond that provided by the EUV and XUV wavelengths, provide electron density input into the lower atmosphere at the footpoints, and provide plasma flows of chromospheric evaporation, among other characteristics.
Endogenous hepadnaviruses, bornaviruses and circoviruses in snakes.
Gilbert, C; Meik, J M; Dashevsky, D; Card, D C; Castoe, T A; Schaack, S
2014-09-22
We report the discovery of endogenous viral elements (EVEs) from Hepadnaviridae, Bornaviridae and Circoviridae in the speckled rattlesnake, Crotalus mitchellii, the first viperid snake for which a draft whole genome sequence assembly is available. Analysis of the draft assembly reveals genome fragments from the three virus families were inserted into the genome of this snake over the past 50 Myr. Cross-species PCR screening of orthologous loci and computational scanning of the python and king cobra genomes reveals that circoviruses integrated most recently (within the last approx. 10 Myr), whereas bornaviruses and hepadnaviruses integrated at least approximately 13 and approximately 50 Ma, respectively. This is, to our knowledge, the first report of circo-, borna- and hepadnaviruses in snakes and the first characterization of non-retroviral EVEs in non-avian reptiles. Our study provides a window into the historical dynamics of viruses in these host lineages and shows that their evolution involved multiple host-switches between mammals and reptiles. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
Heavy metals from pyrotechnics in New Years Eve snow
NASA Astrophysics Data System (ADS)
Steinhauser, Georg; Sterba, Johannes H.; Foster, Michaela; Grass, Friedrich; Bichler, Max
Pyrotechnics and fireworks cause pollution with barium aerosols, which is a result of the utilization of barium nitrate as a combined pyrotechnic oxidizer and coloring agent. In this study, the washing-out of barium-rich aerosols by snowflakes during the New Years Eve celebrations in an Austrian village in the Alps has been investigated. It could be shown that the fireworks caused an increase in the barium concentration in snow of up to a factor of 580 compared to the blank value. An increase of the concentrations of strontium and occasionally arsenic in snow was also observed. The geographic distribution of the pyrotechnic combustion products on this snowy evening was restricted to a relatively small area and even in a very local scale, the variations in the concentrations were remarkable. Post-firework snow from the summits of nearby located mountains was found to be as clean as pre-firework snow. However, snow that was visibly contaminated with smoke residues contained exorbitant concentrations of Ba, K, Sr, and Fe.
"ADAM' or "EVE'?--a toxicological conundrum.
Cox, D E; Williams, K R
1996-01-12
The 3,4-methylenedioxy ring-substituted amphetamines, including "ADAM' and "EVE', are currently popular drugs of abuse. Adverse reactions are reported in the clinical literature but few fatal cases are documented and little toxicological data is available to guide those determining the cause or manner of death in such cases. We report two deaths presenting in a similar manner and with similar clinical features. Various body fluid samples were analysed for amphetamines by gas chromatography/mass spectrometry. In one case, amphetamine alone was detected at levels of 1.54 mg/l and 1.47 mg/l in postmortem blood and admission serum, respectively. The other involved several 3,4-methylenedioxy ring-substituted amphetamines, namely MDA, MDMA and MDEA, at levels of 0.25 mg/l, 0.43 mg/l and 0.3 mg/l, respectively in postmortem femoral blood and 0.24 mg/l, 0.55 mg/l and 0.49 mg/l in admission blood. The interpretation of these toxicological results and some novel legal issues are discussed.
Conical pitch angle distributions of very low-energy ion fluxes observed by ISEE 1
NASA Technical Reports Server (NTRS)
Horwitz, J. L.; Baugher, C. R.; Chappell, C. R.; Shelley, E. G.; Young, D. T.
1982-01-01
Observations are presented of conical distributions of low-energy ion fluxes from throughout the magnetosphere. The data were provided by the plasma composition experiment (PCE) on ISEE 1. ISEE 1 was launched in October 1977 into a highly elliptical orbit with a 30 deg inclination to the equator and 22.5 earth radii apogee. Particular attention is given to data taken when the instrument was in its thermal plasma mode, sampling ions in the energy per charge range 0-100 eV/e. Attention is given to examples of conical distributions in 0- to 100-eV/e ions, the occurrence of conical distributions of 0- to 100-eV ions in local time-geocentric distance and latitude-geocentric distance coordinates, the cone angles in 0- to 100-eV ion conics, Kp distributions of 0- to 100-eV ion conics, and some compositional aspects of 0- to 100-eV ion conics.
2014-08-17
ISS040-E-095609 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.
2011-06-07
Expedition 28 JAXA (Japan Aerospace Exploration Agency) Flight Engineer Satoshi Furukawa places a mission sticker on the inside wall of the prime crew bus on the eve of his launch to the International Space Station, Tuesday, June 7, 2011 at the Baikonur Cosmodrome in Kazakhstan. Photo Credit: (NASA/Roscosmos/Andrey Shelepin)
View Expedition 21 FE-2 Stott posing for a photo in the US Lab
2009-11-24
S129-E-009497 (24 Nov. 2009) --- Astronaut Nicole Stott, STS-129 mission specialist, takes one of her final “strolls” through the modules and hatchways of the International Space Station on the eve of her departure from the orbital outpost.
2014-08-17
ISS040-E-095619 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.
2014-08-17
ISS040-E-095615 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.
2014-08-17
ISS040-E-095617 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.
2014-08-17
ISS040-E-095612 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.
Polymerase Chain Reaction for Detection of Systemic Plant Pathogens
USDA-ARS?s Scientific Manuscript database
This chapter outlines the advances and application of the polymerase chain reaction (PCR) since its development in 1984 and its enhancements and applications to detection of viruses, viroids and phytoplasma in pome and stone fruits. PCR is probably the most rapidly and widely adopted technology eve...
Nitrification event detection in chloraminated drinking water distribution systems (DWDSs) remains an ongoing challenge for many drinking water utilities, including Dallas Water Utilities (DWU) and the City of Houston (CoH). Each year, these utilities experience nitrification eve...
Nitrification event detection in chloraminated drinking water distribution systems (DWDSs) remains an ongoing challenge for many drinking water utilities, including Dallas Water Utilities (DWU) and the City of Houston (CoH). Each year, these utilities experience nitrification eve...
[History and evolution of the organization of health care in prisons].
Bodon-Bruzel, Magali
2013-03-01
It was on the eve of the French Revolution, with the trend for health and philanthropy, that the focus on the health of prisoners, including their mental health, started to evolve. However, psychiatric care for prisoners only became widespread after the Second World War.
Saadat, Soheil; Naseripour, Masood; Smith, Gary A
2010-07-01
Fireworks are used worldwide as a part of national and cultural celebrations. Personal use of fireworks is associated with serious injuries. The "Last Wednesday Eve Festival" is celebrated on the evening before the last wednesday of the Persian calendar year. In recent years, fireworks have been widely used during the festival, which has resulted in injuries. The aim of this study was to determine the incidence and risk factors of fireworks-related injuries associated with the Last Wednesday Eve Festival, in Tehran, Iran. A household survey of residents of greater Tehran, using a random cluster sampling design was performed. Number of fireworks-related injuries, expenditures for fireworks and medical treatment of fireworks-related injuries, length of hospital stay for treatment of these injuries and the personal property damage was gathered. Interviews were conducted of 2475 households in greater Tehran. At least one member of 19.8% of these households had used fireworks during the 2007 Last Wednesday Eve Festival. Fireworks-related injuries were more common among households whose members had used homemade fireworks than among households whose members had used only commercially made fireworks (OR=16.5, 95% CI: 5.7-47.5). Forty-five households reported that they had sustained personal property damage caused by fireworks during the festival, costing a mean of US$ 36.60. Households with at least one injured member spent a mean of US$ 441.90 for medical care and a mean of US$ 70.80 for other expenses related to seeking medical care. The overall incidence of fireworks-related injury among household members was 0.2% (95% CI: 0.1-0.3%). Fireworks-related injury incidence was highest in the 10-19 age group. The total estimated number of fireworks-related injuries in Tehran during the 2007 Last Wednesday Eve Festival was approximately 17,000. Among the 20 injured individuals, 4 persons (20.0%) were hospitalised for a mean of 2.8 days. The personal use of fireworks in Iran is associated with serious injuries and non-trivial economic costs. This study is the first to describe the incidence and economic costs of fireworks-related injuries in a major city in Iran using a population-based survey. To prevent these injuries, individuals should attend public fireworks displays conducted by professionals rather than engage in personal use of fireworks. 2009 Elsevier Ltd. All rights reserved.
Do dogs bite without warning, or should we see it coming?
2017-01-14
When dog bites occur, many owners will report the incident as being 'out of character' for the dog and as happening 'out of the blue'. But do dogs provide warning signs before biting and should owners and vets be able to see it coming? This question was explored in a session during the London Vet Show. Laura Honey reports. British Veterinary Association.
Fulfilling Dreams in Adult Education: Managing the Multi-Level Classroom
ERIC Educational Resources Information Center
Haley, Rebecca J.
2008-01-01
Have you ever wondered how Laura Ingalls Wilder taught all of her students in the little one-room school house in The Little House on the Prairie series? How did she teach students on so many different levels and all at the same time? Well, that is exactly what it is like in most adult education classrooms today. The purpose of this paper is to…
Biosecurity of Select Agents and Toxins
2005-03-01
effort. As important, the encouragement and support provided my wife, Peggy, and my daughter, Laura, enabled me to accomplish this personal and...affiliations of the scholars involved. Visitors, scholars and other interested persons are commonplace on campus and cause neither alarm nor concern within that...Since its initial adoption in Washington, London, and Moscow in 1972, the treaty signatories have pledged to realize the goals outlined in Article I
Design Methodology for Automated Construction Machines
1987-12-11
along with the design of a pair of machines which automate framework installation.-,, 20. DISTRIBUTION IAVAILABILITY OF ABSTRACT 21. ABSTRACT SECURITY... Development Assistant Professor of Civil Engineering and Laura A . Demsetz, David H. Levy, Bruce Schena Graduate Research Assistants December 11, 1987 U.S...are discussed along with the design of a pair of machines which automate framework installation. Preliminary analysis and testing indicate that these
Explaining and Influencing Chinese Arms Transfers
1995-02-01
this volume: Jonathan W. Pierce [] Secretary: Laura Hall [] Circulation Manager : Myma Morgan INSS publishes McNair Papers to provoke thought and inform...their affiliated factories were directed to decentralize their decision-making processes, grant more autonomy to managers , use excess capacity to...intimacy of ties between Moscow and 10 EXPLAINING AND INFLUENCING CHINESE ARMS TRANSFERS New Dehli , and concem that the United States was still in retreat
Improving Air Force Enterprise Resource Planning-Enabled Business Transformation
2013-01-01
of the time of the research. - xviii - At RAND, we thank Mr. Jerry Sollinger for helping us to organize our material and Dr. Laura Baldwin for...complex technology effort most public-sector organizations will ever attempt” ( KPMG , 2011). While many of the challenges listed above may manifest... KPMG LLP, 2011). 1 Multi-echelon means one person is in charge and has responsibility for
ERIC Educational Resources Information Center
Enriquez, Laura E.
2011-01-01
Drawing from the educational experiences of fifty-four undocumented immigrant college students, Laura E. Enriquez seeks to uncover the concrete ways in which social capital is used to successfully navigate K-12 educational institutions and pursue a higher education. Enriquez argues that there is a need for a more grounded understanding of how…
Data Collection Methods. Semi-Structured Interviews and Focus Groups
2009-01-01
erence. For example, consider the dif- ferences between informants, subjects, respondents, and actors.3 Bernard (2000) notes that anthropology generally...Cohesion, and Morale, Santa Monica, Calif.: RAND Corporation, MR-896-OSD, 1997; and Margaret C. Harrell, Laura Werber Castaneda, Peter Schirmer, Bryan...not divulging “secrets” if the researcher already knows ( Bernard , 2002). There are a couple of potential problems with probes for which the
RAND Project Air Force Annual Report 2008
2008-01-01
Systems: Past Lessons and Future Recommendations, by Obaid Younossi, Mark A. Lorell, Kevin Brancato, Cynthia R. Cook, Mel Eisman, Bernard Fox, John C...Competency Development: Experience from Prince Sultan Air Base and Eskan Village in Saudi Arabia, by Laura Werber Castaneda, Lawrence M. Hanser, and...Proposal, by Michael R. Thirtle, Michael Boito, Ian P. Cook, Bernard Fox, Phyllis Gilmore, Michelle Grace, Jeff Hagen, Thomas Hamilton
2005-01-01
information for planning and management. MG-109-AF, Test and Evaluation Trends and Costs for Aircraft and Guided Weapons, Bernard Fox, Michael Boito...Experience fom Prince Sultan Air Base and Eskan Village in Saudi Arabia, Laura Werber Castaneda, Lawrence M. Hanser, and Constance H. Davis 28 RAND...India, C. Christine Fair ANNUAL REPORT 2004 47 Publications MG-109-AF, Test and Evaluation Trends and Costs for Aircraft and Guided Weapons, Bernard Fox
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-12
... or other forms of information technology. Comments may be sent to: Laura Castro, Branch Chief, Policy... individuals and households, 500 businesses and other for-profit companies, 11,211 private not-for-profit....00 542.37 178,980.93 0.12 21,935.87 Governments Private For Profit 500.00 9.12 4,560.00 1.04 4,740.00...
Reduction and Analysis of Phosphor Thermography Data With the IHEAT Software Package
NASA Technical Reports Server (NTRS)
Merski, N. Ronald
1998-01-01
Detailed aeroheating information is critical to the successful design of a thermal protection system (TPS) for an aerospace vehicle. This report describes NASA Langley Research Center's (LaRC) two-color relative-intensity phosphor thermography method and the IHEAT software package which is used for the efficient data reduction and analysis of the phosphor image data. Development of theory is provided for a new weighted two-color relative-intensity fluorescence theory for quantitatively determining surface temperatures on hypersonic wind tunnel models; an improved application of the one-dimensional conduction theory for use in determining global heating mappings; and extrapolation of wind tunnel data to flight surface temperatures. The phosphor methodology at LaRC is presented including descriptions of phosphor model fabrication, test facilities and phosphor video acquisition systems. A discussion of the calibration procedures, data reduction and data analysis is given. Estimates of the total uncertainties (with a 95% confidence level) associated with the phosphor technique are shown to be approximately 8 to 10 percent in the Langley's 31-Inch Mach 10 Tunnel and 7 to 10 percent in the 20-Inch Mach 6 Tunnel. A comparison with thin-film measurements using two-inch radius hemispheres shows the phosphor data to be within 7 percent of thin-film measurements and to agree even better with predictions via a LATCH computational fluid dynamics solution (CFD). Good agreement between phosphor data and LAURA CFD computations on the forebody of a vertical takeoff/vertical lander configuration at four angles of attack is also shown. In addition, a comparison is given between Mach 6 phosphor data and laminar and turbulent solutions generated using the LAURA, GASP and LATCH CFD codes. Finally, the extrapolation method developed in this report is applied to the X-34 configuration with good agreement between the phosphor extrapolation and LAURA flight surface temperature predictions. The phosphor process outlined in the paper is believed to provide the aerothermodynamic community with a valuable capability for rapidly obtaining (4 to 5 weeks) detailed heating information needed in TPS design.
The Influence of Ablation on Radiative Heating for Earth Entry
NASA Technical Reports Server (NTRS)
Johnston, Christopher O.; Gnoffo, Peter A.; Sutton, Kenneth
2008-01-01
Using the coupled ablation and radiation capability recently included in the LAURA flowfield solver, this paper investigates the influence of ablation on the shock-layer radiative heating for Earth entry. The extension of the HARA radiation model, which provides the radiation predictions in LAURA, to treat a gas consisting of the elements C, H, O, and N is discussed. It is shown that the absorption coefficient of air is increased with the introduction of the C and H elements. A simplified shock layer model is studied to show the impact of temperature, as well as the abundance of C and H, on the net absorption or emission from an ablation contaminated boundary layer. It is found that the ablation species reduce the radiative flux in the vacuum ultraviolet, through increased absorption, for all temperatures. However, in the infrared region of the spectrum, the ablation species increase the radiative flux, through strong emission, for temperatures above 3,000 K. Thus, depending on the temperature and abundance of ablation species, the contaminated boundary layer may either provide a net increase or decrease in the radiative flux reaching the wall. To assess the validity of the coupled ablation and radiation LAURA analysis, a previously analyzed Mars-return case (15.24 km/s), which contains significant ablation and radiation coupling, is studied. Exceptional agreement with previous viscous shock-layer results is obtained. A 40% decrease in the radiative flux is predicted for ablation rates equal to 20% of the free-stream mass flux. The Apollo 4 peak-heating case (10.24 km/s) is also studied. For ablation rates up to 3.4% of the free-stream mass flux, the radiative heating is reduced by up to 19%, while the convective heating is reduced by up to 87%. Good agreement with the Apollo 4 radiometer data is obtained by considering absorption in the radiometer cavity. For both the Mars return and the Apollo 4 cases, coupled radiation alone is found to reduce the radiative heating by 30 60% and the convective heating by less than 5%.
DefenseLink Special: Travels with Rumsfeld, June 2006
: Ironic That Zarqawi Dies on Eve of Iraq Government Successes Ministers Discuss Alliance's Security leaders here today to discuss how the relationship between the United States and this South Pacific Troops Home * Rumsfeld in Vietnam to Meet Leaders, Discuss MIA Recovery Defense Secretary Visits Sailors
Noah and EVE (Environmental Values Education).
ERIC Educational Resources Information Center
Knapp, Clifford
1995-01-01
Environmental ethics provide a set of related values that help to limit or restrict individual freedom in order to save and protect nature. Examples of environmental ethics include land ethics, deep ecology, social ecology, Native or first peoples' worldviews, reverence for life, and conservation and management. Includes teaching strategies and a…
Area Handbook Series: Japan: A Country Study
1992-01-01
special decorations, eating noodles on New Year’s Eve to show continuity into the new year, and playing a poetry card game are among the more...transmitted by satellite for instant replay after the government, in 1979, set up the Communications and Broadcasting Satellite Or- ganization. Japan’s first
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-13
...[deg]30'29.61'' W (NAD 83). Upon the commencement of the fireworks display, scheduled to begin at 9 p.m....61'' W (NAD 83) within a radius of 1,000 feet. At the conclusion of the fireworks display the safety...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-11
...[deg]30'29.61'' W (NAD 83). Upon the commencement of the fireworks display, scheduled to begin at 9 p.m..., 121[deg]30'29.61'' W (NAD 83) within a radius of 1,000 feet. At the conclusion of the fireworks...
An Online Image Analysis Tool for Science Education
ERIC Educational Resources Information Center
Raeside, L.; Busschots, B.; Waddington, S.; Keating, J. G.
2008-01-01
This paper describes an online image analysis tool developed as part of an iterative, user-centered development of an online Virtual Learning Environment (VLE) called the Education through Virtual Experience (EVE) Portal. The VLE provides a Web portal through which schoolchildren and their teachers create scientific proposals, retrieve images and…
The New Spirit of Capitalism in European Liberal Arts Programs
ERIC Educational Resources Information Center
Claus, Jakob; Meckel, Thomas; Pätz, Farina
2018-01-01
The following paper suggests a connection between recent developments in the justification of the capitalist system and contemporary European Liberal Arts programs. By looking at Luc Boltanski's and Eve Chiapello's study on "The New Spirit Of Capitalism" and Gilles Deleuze's term of "societies of control" we highlight a pivot…
On the Razor's Edge: The Irish-American Press on the Eve of World War One.
ERIC Educational Resources Information Center
Mulcrone, Mick
A study examined three partisan Irish-American newspapers ("Irish World,""Gaelic-American," and the "Leader") representative of the Irish-American press before the First World War. The newspapers appealed to different constituencies, had contrasting orientations, and enjoyed substantial influence within the…
Arts-Based Leadership: Theatrical Tributes
ERIC Educational Resources Information Center
Soumerai, Eve Nussbaum; Mazer, Rachel
2006-01-01
The first part of this article describes how, as an independent educator, Eve Nussbaum Soumerai developed numerous theatrical tributes to inspirational historical figures (Anne Frank, Martin Luther King, Jr., and the Dalai Lama, for example). By participating in these productions, young people learned about the lives of these figures and shared…
VULNERABILITY OF ECOSYSTEMS OF THE MID-ATLANTIC REGION, USA, TO CLIMATIC CHANGE
Changes in the distribution of vegetation in the mid-Atlantic region of the United States were explored for two climate-change scenarios. The equilibrium vegetation ecology (EVE) model was used to project the distribution of life forms and to combine these into biomes for a doubl...
ERIC Educational Resources Information Center
Wenner, Adrian M.
1973-01-01
The present conflict between creationists and evolutionists may appear to be focused on demanding equal time in school curriculum, but an attack may be made in the future on the scientific method itself. Stronger arguments should be made against creationists' viewpoint to uphold the rationale of scientific scrutiny before accepting a belief as…
Eventos de Diciembre (December Events).
ERIC Educational Resources Information Center
Pla, Myrna; Toro, Leonor
Written in Spanish, this booklet contains information on three events occurring in the month of December: winter, Christmas, and New Year's Eve. Winter is briefly discussed. The section on Christmas includes a short story ("La Nochebuena"); a poem about Christmas in Puerto Rico; a legend about the poinsettia; brief discussion of Santa…
Recruitment and Selection of Minorities in High-Tech Organizations. A Sociological Perspective.
1984-09-01
Gretchen M. Luebbe Doris R. Entwisle Nancy A. Madden Joyce L. Epstein Kirk Nabors James Fennessey Alejandro Portes Denise C. Gottfredson Donald C. Rickert...Jr. Gary D. Gottfredson Laura Hersh Salganik Linda S. Gottfredson Robert E. Slavin Edward J. Harsch Jane St. John John H. Hollifield Valarie...and intelligence --as the primary determinants of minority and female underrepresentation in high-tech occupations. Despite voluminous research
Using Cognitive Task Analysis and Eye Tracking to Understand Imagery Analysis
2006-01-01
Using Cognitive Task Analysis and Eye Tracking to Understand Imagery Analysis Laura Kurland, Abigail Gertner, Tom Bartee, Michael Chisholm and...have used these to study the analysts search behavior in detail. 2 EXPERIMENT Using a Cognitive Task Analysis (CTA) framework for knowledge...TITLE AND SUBTITLE Using Cognitive Task Analysis and Eye Tracking to Understand Imagery Analysis 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM
U.S. Army Research Institute Program in Basic Research FY 2004
2005-08-01
reports from these research efforts is available upon request. Paul A. Gade, Chief, Research and Advanced Concepts Office Laura Wheeler Poms, Consortium...subjects during the time when they are most awake; making sure subjects are not sick, hungry , or taking any performance-enhancing drugs other than...received growing confirmation in a range of other sciences. Neuropsychological studies of ultimatum game performance have confirmed the role of brain
Organizational Effectiveness in the Tanker Airlift Control Center
2008-05-01
Institute 300 College Park Dayton OH 45469 Anne K. Offner Offner and Associates, Inc. Kirkwood MO 63122 Greg Padula C5T Corporation...ELEMENT NUMBER 62202F 6. AUTHOR(S) 1Laura G. Militello, 2Anne K. Offner, 3Greg Padula , 5d. PROJECT NUMBER 4Stephanie D. Swindler...is taken largely from Padula (2007). This excerpt from Padula ‟s International Symposium on Aviation Psychology (ISAP) proceedings paper conveys the
Air Force Service Procurement. Approaches for Measurement and Management
2005-01-01
2003, Ritz - Carlton Hotel , Arlington, Vir- ginia. 15 We used a variety of search terms for the business literature review, including purchased services... Carlton Hotel , Arlington, Va., June 5, 2003. Shirley, Chad, John Ausink, and Laura H. Baldwin, Measuring Changes in Service Costs to Meet the Requirements...Richter, Gene, "Ten Private Sector Best Practices," presentation at the Pro- curement Executive Roundtable sponsored by the SAS Institute, Ritz
Application of Long Distance Conveyance (LDC) of Dredged Sediments to Louisiana Coastal Restoration
2011-01-01
U.S. Army Engineer District, New Orleans, Laura Beldon, Louisiana Office of Coastal Protection and Restoration, Cheryl Brodnax, National...Louisiana Department of Natural Resources, Christopher Knotts , Louisiana Department of Natural Resources, Fay Lachney, MVN, Luke LeBas, Louisiana...associated with the petrochemical industry (e.g., Van Dyke et al. 1994) or backfilled canals dredged as part of the pipeline installation (e.g., Knott et al
Towards a Fiscally Constrained Pacific Posture
2012-03-21
joint press conference with Australian Prime Minister Julia Gillard , President Obama emphasized U.S. intent in the Asia Pacific region when he... gillard -australia-joint-press (accessed February 5, 2012). 5 Laura MacInnis and Caren Bohan, “Obama seeks to hitch U.S. economy to Asian growth,” Reuters...November 16, 2011. http://www.whitehouse.gov/the-press-office/2011/11/16/remarks-president-obama-and-prime- minister- gillard -australia-joint-press
ERIC Educational Resources Information Center
Bonch-Bruevich, Xenia, Ed.; Crawford, William J., Ed.; Hellermann, John, Ed.; Higgins, Christina, Ed.; Nguyen, Hanh, Ed.
This book presents 16 peer-reviewed papers from a 2000 conference on second language research. Part 1, "Formal Investigations of SLA," includes "L2 Acquisition of English Liquids: Evidence for Production Independent from Perception" (Laura Catharine Smith); "Is L2 Learning the Same as L1 Learning? Learning L2 Phonology in…
ERIC Educational Resources Information Center
2003
The Radio-Television Journalism Division of the proceedings contains the following 11 papers: "In Whose Best Interest? FCC Deregulation and Local News: How Cross-Ownership, National Caps, and Duopolies Are Addressed in Three Commissioned Studies" (Laura K. Smith); "Remembering the News: The Effect of Chronological Presentation of…
The First Reactor [40th Anniversary Commemorative Edition].
DOE R&D Accomplishments Database
1982-12-01
This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.
High-Performance Java Codes for Computational Fluid Dynamics
NASA Technical Reports Server (NTRS)
Riley, Christopher; Chatterjee, Siddhartha; Biswas, Rupak; Biegel, Bryan (Technical Monitor)
2001-01-01
The computational science community is reluctant to write large-scale computationally -intensive applications in Java due to concerns over Java's poor performance, despite the claimed software engineering advantages of its object-oriented features. Naive Java implementations of numerical algorithms can perform poorly compared to corresponding Fortran or C implementations. To achieve high performance, Java applications must be designed with good performance as a primary goal. This paper presents the object-oriented design and implementation of two real-world applications from the field of Computational Fluid Dynamics (CFD): a finite-volume fluid flow solver (LAURA, from NASA Langley Research Center), and an unstructured mesh adaptation algorithm (2D_TAG, from NASA Ames Research Center). This work builds on our previous experience with the design of high-performance numerical libraries in Java. We examine the performance of the applications using the currently available Java infrastructure and show that the Java version of the flow solver LAURA performs almost within a factor of 2 of the original procedural version. Our Java version of the mesh adaptation algorithm 2D_TAG performs within a factor of 1.5 of its original procedural version on certain platforms. Our results demonstrate that object-oriented software design principles are not necessarily inimical to high performance.
Dual-Code Solution Strategy for Chemically-Reacting Hypersonic Flows
NASA Technical Reports Server (NTRS)
Wood, William A.; Eberhardt, Scott
1995-01-01
A new procedure seeks to combine the thin-layer Navier-Stokes solver LAURA with the parabolized Navier-Stokes solver UPS for the aerothermodynamic solution of chemically-reacting air flow fields. The interface protocol is presented and the method is applied to two slender, blunted shapes. Both axisymmetric and three-dimensional solutions are included with surface pressure and heat transfer comparisons between the present method and previously published results. The case of Mach 25 flow over an axisymmetric six degree sphere-cone with a non-catalytic wall is considered to 100 nose radii. A stability bound on the marching step size was observed with this case and is attributed to chemistry effects resulting from the non-catalytic wall boundary condition. A second case with Mach 28 flow over a sphere-cone-cylinder-flare configuration is computed at both two and five degree angles of attack with a fully-catalytic wall. Surface pressures are seen to be within five percent with the present method compared to the baseline LAURA solution and heat transfers are within 10 percent. The effect of grid resolution is investigated in both the radial and streamwise directions. The procedure demonstrates significant, order of magnitude reductions in solution time and required memory for the three-dimensional case in comparison to an all thin-layer Navier-Stokes solution.
View of STS-134 Crew Members working on the Middeck
2011-05-17
S134-E-006520 (17 May 2011) --- Astronauts Andrew Feustel (foreground) and Michael Fincke, both STS-134 mission specialists, work to keep order with the large inventory of supplies and equipment on Endeavour's middeck and airlock on the eve of docking day with the International Space Station. Photo credit: NASA.
2011-06-07
Expedition 28 NASA Flight Engineer displays the Expedition 29 crew sticker while riding on the prime crew bus to Building 254 the eve of his launch to the International Space Station, Tuesday, June June 7, 2011 at the Baikonur Cosmodrome in Kazakhstan. Fossum will be the ISS Commander for Expedition 29. Photo Credit: (NASA/Roscosmos/Andrey Shelepin)
Cyclone Tracy and the Darwin Educators: A Case in Crisis Management.
ERIC Educational Resources Information Center
Beare, Hedley
The story of successful crisis management teaches some lessons applicable not only to surmounting crises but to everyday management decisions as well. On Christmas eve, 1974, a cyclone demolished 90 percent of the city of Darwin in Australia's Northern Territory. As thousands gathered in neighborhood schools, a team of educational administrators…
Beyond Rhetoric: A Recipe for Civil Society Action on Literacy
ERIC Educational Resources Information Center
Tanvir, Mohammad Muntasim
2007-01-01
On the eve of CONFINTEA VI, discussion and debates on promoting literacy is being revived. However, in most cases, the discussion limits itself to the definitional nuances of literacy and falls short of critiquing the global policy making inertia that violates the human rights obligations to the millions of adults remaining illiterate. This…
An Intelligence Collection Management Model.
1984-06-01
classification of inteligence collection requirements in terms of. the a-.- metnodo"c, .ev--e in Chaster Five. 116 APPgENDIX A A METHOD OF RANKING...of Artificial Intelligence Tools and Technigues to!TN’X n~l is n rs aa~emfft-.3-ufnyva: ’A TZ Ashby W. Ecss. An Introduction to Cybernetics. New York
Quantum cryptography as a retrodiction problem.
Werner, A H; Franz, T; Werner, R F
2009-11-27
We propose a quantum key distribution protocol based on a quantum retrodiction protocol, known as the Mean King problem. The protocol uses a two way quantum channel. We show security against coherent attacks in a transmission-error free scenario, even if Eve is allowed to attack both transmissions. This establishes a connection between retrodiction and key distribution.
Engineering Safety- and Security-Related Requirements for Software-Intensive Systems
2010-04-27
Requirements Negative (shall not) Requirements Hardware Requirements equ remen s System / Documentation Requirements eve oper Requirements Operational ...Validation Actual / Proposed Defensibility C li Operational Vulnerability Analysis VulnerabilityVulnerability Safety Vulnerability performs System ...including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson
Robotics Team Lights Up New Year's Eve
ERIC Educational Resources Information Center
LeBlanc, Cheryl
2011-01-01
A robotics team from Muncie, Indiana--the PhyXTGears--is made up of high school students from throughout Delaware County. The group formed as part of the FIRST Robotics program (For Inspiration and Recognition of Science and Technology), an international program founded by inventor Dean Kamen in which students work with professional engineers and…
Towards a History of the Encyclopedia from Jerome to Isidor.
ERIC Educational Resources Information Center
Jackson, S.
1981-01-01
Traces the evolution of the idea of an encyclopedia from Jerome, who worked mainly in Caesarea in Palestine towards the end of the Roman Empire, through the work of Augustine, Martianus Capella, Boethius, and Cassiodorus Senator, to Isidor, who worked in Seville on the eve of the Carolingian Renaissance. (LLS)
Suspending Damage: A Letter to Communities
ERIC Educational Resources Information Center
Tuck, Eve
2009-01-01
In this open letter, Eve Tuck calls on communities, researchers, and educators to reconsider the long-term impact of "damage-centered" research--research that intends to document peoples' pain and brokenness to hold those in power accountable for their oppression. This kind of research operates with a flawed theory of change: it is often used to…
Army Strong, Superintendent Savvy
ERIC Educational Resources Information Center
Mellon, Ericka
2011-01-01
Brigadier General Anthony "Tony" Tata of the U.S. Army had one of those "ah-ha" moments in April 2006 when, on the eve of an operation he was heading in Afghanistan, an Al Qaeda rocket shattered a nearby school. The attack killed a teacher and seven students and wounded dozens more. The rocket incident eventually nudged Tata…
Crisis of Black Athletes on the Eve of the 21st Century.
ERIC Educational Resources Information Center
Edwards, Harry
2000-01-01
Asserts that the dynamics of black youth sports involvement and the blind faith of black youths and families in sports as a vehicle for self-realization and socioeconomic advancement generate complex problems for black society. Black families often push their children toward sports careers, neglecting personal and cultural development. Discusses…
Solar Dynamics Observatory Lessons Learned
NASA Technical Reports Server (NTRS)
Rivera, Rachel; Uhl, Andrew; Secunda, Mark
2010-01-01
Mission is to study how solar activity is created and how space weather results from that activity. Atmospheric Imaging Assembly (AIA): High Resolution Images of 10 wavelengths every 10 seconds. Extreme Ultraviolet Variability Experiment (EVE): Measure Sun's brightness in EUV. Helioseismic and Magnetic Imager (HMI): Measures Doppler shift to study waves of the Sun. Launched February 11, 2010.
Religion, Sexual Orientation, and School Policy: How the Christian Right Frames Its Arguments
ERIC Educational Resources Information Center
Macgillivray, Ian K.
2008-01-01
The Christian Right opposes the inclusion of sexual orientation in school policies, charging that the schools are legitimating and promoting homosexuality. The arguments have moved past the trite, "God created Adam and Eve, not Adam and Steve," to claims of violations of parental rights and the First Amendment, often positioning…
The Management of the Knowledge Revolution.
ERIC Educational Resources Information Center
Athanassiades, John C.
This essay on the management of information presents areas of agreement and disagreement about the "knowledge revolution", its general effect on the world population, and its particular effect on libraries and other information systems, as well as on those who are charged with its management. The myth of Adam and Eve is used to symbolize the…
7. VIEW FROM SOUTHEAST OF HEADWALL THAT TERMINATES THE FORECOURT; ...
7. VIEW FROM SOUTHEAST OF HEADWALL THAT TERMINATES THE FORECOURT; VIEW INCLUDES THE OCEANUS FOUNTAIN ON THE TERRACE LEVEL, THE DOUBLE STAIRS, RADIAL PAVING, AND THE ADAM AND EVE FOUNTAIN, IN PINK GRANITE, TUCKED INTO A CENTRAL NICHE CARVED OUT OF HEADWALL - Kykuit, 200 Lake Road, Pocantico Hills, Westchester County, NY
Don Quixote at 400: Still Conquering Hearts
ERIC Educational Resources Information Center
Stavans, Ilan
2005-01-01
The Knight of the Sorrowful Countenance is turning 400. By some accounts, the first part of Don Quixote, Miguel de Cervantes's masterpiece, was available in Valladolid by Christmas Eve 1604, although Madrid did not get copies until January 1605. Thus came to life the "ingenious gentleman" who, ill equipped with antiquated armor "stained with rust…
South African Academia in Crisis: The Spread of "Contrived Collegial Managerialism"
ERIC Educational Resources Information Center
Johnson, B.
2006-01-01
In 1999, on the eve of rationalisation of South African higher education, J. M. Coetzee published a book entitled "Disgrace". In this publication he narrates the tale of a Classics and Modern Languages professor transformed into an adjunct professor of Communications, a marketable identity, as a consequence of rationalisation. Coetzee,…
NASA Astrophysics Data System (ADS)
Yang, Li-Tao; Li, Hau-Bin; Yue, Qian; Kang, Ke-Jun; Cheng, Jian-Ping; Li, Yuan-Jing; Tsz-King Wong, Henry; Aǧartioǧlu, M.; An, Hai-Peng; Chang, Jian-Ping; Chen, Jing-Han; Chen, Yun-Hua; Deng, Zhi; Du, Qiang; Gong, Hui; He, Li; Hu, Jin-Wei; Hu, Qing-Dong; Huang, Han-Xiong; Jia, Li-Ping; Jiang, Hao; Li, Hong; Li, Jian-Min; Li, Jin; Li, Xia; Li, Xue-Qian; Li, Yu-Lan; Lin, Fong-Kay; Lin, Shin-Ted; Liu, Shu-Kui; Liu, Zhong-Zhi; Ma, Hao; Ma, Jing-Lu; Pan, Hui; Ren, Jie; Ruan, Xi-Chao; Sevda, B.; Sharma, Vivek; Shen, Man-Bin; Singh, Lakhwinder; Singh, Manoj Kumar; Tang, Chang-Jian; Tang, Wei-You; Tian, Yang; Wang, Ji-Min; Wang, Li; Wang, Qing; Wang, Yi; Wu, Shi-Yong; Wu, Yu-Cheng; Xing, Hao-Yang; Xu, Yin; Xue, Tao; Yang, Song-Wei; Yi, Nan; Yu, Chun-Xu; Yu, Hai-Jun; Yue, Jian-Feng; Zeng, Xiong-Hui; Zeng, Ming; Zeng, Zhi; Zhang, Yun-Hua; Zhao, Ming-Gang; Zhao, Wei; Zhou, Ji-Fang; Zhou, Zu-Ying; Zhu, Jing-Jun; Zhu, Zhong-Hua; CDEX Collaboration
2018-01-01
We report results of a search for light weakly interacting massive particle (WIMP) dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory (CJPL). Constraints on WIMP-nucleon spin-independent (SI) and spin-dependent (SD) couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV. Supported by the National Key Research and Development Program of China (2017YFA0402200, 2017YFA0402201), the National Natural Science Foundation of China (11175099, 11275107, 11475117, 11475099, 11475092, 11675088), the National Basic Research Program of China (973 Program) (2010CB833006). We thank the support of grants from the Tsinghua University Initiative Scientific Research Program (20121088494, 20151080354) and the Academia Sinica Investigator Award 2011-15, contracts 103-2112-M-001-024 and 104-2112-M-001-038-MY3 from the Ministry of Science and Technology of Taiwan.
Powerful Solar Flares in September 2017. Comparison with the Largest Flares in Cycle 24
NASA Astrophysics Data System (ADS)
Bruevich, E. A.; Bruevich, V. V.
2018-06-01
Solar flare activity in cycle 24 is studied. Satellite observations of x-ray fluxes from GOES-15 and UV emission lines from the SDO/EVE experiment are used. The most powerful flares of cycle 24 in classes X9.3 and X8.2 in September 2017 are compared with powerful flares in classes M5-X6.9. The times at which the fluxes in the 30.4 and 9.4 nm lines and in the 0.1-0.8 nm x-ray range begin to increase are compared for 21 of the large flares. The total energies arriving at the earth from flares in the 30.4 and 9.4 nm lines and in the 0.1-0.9 nm x-ray range, E30.4, E9.4, and E0.1-0.8, from 25 flares during 2011 and 2012 are calculated. It is shown that the calculated energies of the flares in the analyzed lines from SDO/EVE and in the x-ray range from GOES-15 are closely interrelated.
Dynamics of a village--marketing strategies for a new millennium.
Farran, H
1999-06-01
Successfully marketing a dental practice involves more than an ad in the yellow pages. Choosing a dentist is a decision based on emotion. Dentists who take steps to become involved in their communities and interact with people will reap the personal and professional rewards necessary for a successful practice. From the beginning of recorded time, humans have been strongly influenced by personal recommendations. It started in the Garden of Eden. Eve said to Adam, "Go ahead, taste this fruit." He didn't read about the fruit in a slick, full-color brochure. He didn't hear about it on television in a strategically placed commercial. He made his decision based on only one thing: Eve's recommendation. The power of a personal recommendation is still one of the strongest motivating factors in our society. People do not choose a good restaurant based on the size of its ad in the telephone directory. How many times have you told someone about a movie, and they saw it based on your recommendation? The synergy of human communication is the most powerful component of economic stability in a village.
Struffi, Paolo; Corado, Maria; Kaplan, Leah; Yu, Danyang; Rushlow, Christine; Small, Stephen
2011-01-01
Despite years of study, the precise mechanisms that control position-specific gene expression during development are not understood. Here, we analyze an enhancer element from the even skipped (eve) gene, which activates and positions two stripes of expression (stripes 3 and 7) in blastoderm stage Drosophila embryos. Previous genetic studies showed that the JAK-STAT pathway is required for full activation of the enhancer, whereas the gap genes hunchback (hb) and knirps (kni) are required for placement of the boundaries of both stripes. We show that the maternal zinc-finger protein Zelda (Zld) is absolutely required for activation, and present evidence that Zld binds to multiple non-canonical sites. We also use a combination of in vitro binding experiments and bioinformatics analysis to redefine the Kni-binding motif, and mutational analysis and in vivo tests to show that Kni and Hb are dedicated repressors that function by direct DNA binding. These experiments significantly extend our understanding of how the eve enhancer integrates positive and negative transcriptional activities to generate sharp boundaries in the early embryo. PMID:21865322
Thermodynamic Spectrum of Solar Flares Based on SDO/EVE Observations: Techniques and First Results
NASA Technical Reports Server (NTRS)
Wang, Yuming; Zhou, Zhenjun; Zhang, Jie; Liu, Kai; Liu, Rui; Shen, Chenglong; Chamberlin, Phillip C.
2016-01-01
The Solar Dynamics Observatory (SDO)/EUV Variability Experiment (EVE) provides rich information on the thermodynamic processes of solar activities, particularly on solar flares. Here, we develop a method to construct thermodynamic spectrum (TDS) charts based on the EVE spectral lines. This tool could potentially be useful for extreme ultraviolet (EUV) astronomy to learn about the eruptive activities on distant astronomical objects. Through several cases, we illustrate what we can learn from the TDS charts. Furthermore, we apply the TDS method to 74 flares equal to or greater than the M5.0 class, and reach the following statistical results. First, EUV peaks are always behind the soft X-ray (SXR) peaks and stronger flares tend to have faster cooling rates. There is a power-law correlation between the peak delay times and the cooling rates, suggesting a coherent cooling process of flares from SXR to EUV emissions. Second, there are two distinct temperature drift patterns, called Type I and Type II. For Type I flares, the enhanced emission drifts from high to low temperature like a quadrilateral, whereas for Type II flares the drift pattern looks like a triangle. Statistical analysis suggests that Type II flares are more impulsive than Type I flares. Third, for late-phase flares, the peak intensity ratio of the late phase to the main phase is roughly correlated with the flare class, and the flares with a strong late phase are all confined. We believe that the re-deposition of the energy carried by a flux rope, which unsuccessfully erupts out, into thermal emissions is responsible for the strong late phase found in a confined flare. Furthermore, we show the signatures of the flare thermodynamic process in the chromosphere and transition region in the TDS charts. These results provide new clues to advance our understanding of the thermodynamic processes of solar flares and associated solar eruptions, e.g., coronal mass ejections.
Evaluation of a gaze-controlled vision enhancement system for reading in visually impaired people
Aguilar, Carlos; Castet, Eric
2017-01-01
People with low vision, especially those with Central Field Loss (CFL), need magnification to read. The flexibility of Electronic Vision Enhancement Systems (EVES) offers several ways of magnifying text. Due to the restricted field of view of EVES, the need for magnification is conflicting with the need to navigate through text (panning). We have developed and implemented a real-time gaze-controlled system whose goal is to optimize the possibility of magnifying a portion of text while maintaining global viewing of the other portions of the text (condition 1). Two other conditions were implemented that mimicked commercially available advanced systems known as CCTV (closed-circuit television systems)—conditions 2 and 3. In these two conditions, magnification was uniformly applied to the whole text without any possibility to specifically select a region of interest. The three conditions were implemented on the same computer to remove differences that might have been induced by dissimilar equipment. A gaze-contingent artificial 10° scotoma (a mask continuously displayed in real time on the screen at the gaze location) was used in the three conditions in order to simulate macular degeneration. Ten healthy subjects with a gaze-contingent scotoma read aloud sentences from a French newspaper in nine experimental one-hour sessions. Reading speed was measured and constituted the main dependent variable to compare the three conditions. All subjects were able to use condition 1 and they found it slightly more comfortable to use than condition 2 (and similar to condition 3). Importantly, reading speed results did not show any significant difference between the three systems. In addition, learning curves were similar in the three conditions. This proof of concept study suggests that the principles underlying the gaze-controlled enhanced system might be further developed and fruitfully incorporated in different kinds of EVES for low vision reading. PMID:28380004
Dalla Gassa, Alessandra; Felis, Giovanna; Granata, Simona; Torriani, Sandra; Lupo, Antonio
2017-01-01
Background The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined. Methods We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols. Nine patients were treated with everolimus plus mycophenolate mofetil (EVE+MMF group), and 11 patients were treated with a standard therapy with tacrolimus plus mycophenolate mofetil (TAC+MMF group). Results A statistical analysis of comparative high-throughput data demonstrated that although similar according to the degree of Shannon diversity (alpha diversity) at the taxonomic level, three functional genes clearly discriminated EVE+MMF versus TAC+MMF (cutoff: log2 fold change≥1, FDR≤0.05). Flagellar motor switch protein (fliNY) and type IV pilus assembly protein pilM (pilM) were significantly enriched in TAC+MMF-treated patients, while macrolide transport system mrsA (msrA) was more abundant in patients treated with EVE+MMF. Finally, PERMANOVA revealed that among the variables analyzed and included in our model, only the consumption of sugar significantly influenced beta diversity. Conclusions Our study, although performed on a relatively small number of patients, showed, for the first time, specific immunosuppressive-related effects on fecal microbiome of renal transplant recipients and it suggested that the analysis of the gut microbes community could represent a new tool to better understand the effects of drugs currently employed in organ transplantations. However, multicenter studies including healthy controls should be undertaken to better address this objective. PMID:28542523
THERMODYNAMIC SPECTRUM OF SOLAR FLARES BASED ON SDO/EVE OBSERVATIONS: TECHNIQUES AND FIRST RESULTS
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wang, Yuming; Zhou, Zhenjun; Liu, Kai
2016-03-15
The Solar Dynamics Observatory (SDO)/EUV Variability Experiment (EVE) provides rich information on the thermodynamic processes of solar activities, particularly on solar flares. Here, we develop a method to construct thermodynamic spectrum (TDS) charts based on the EVE spectral lines. This tool could potentially be useful for extreme ultraviolet (EUV) astronomy to learn about the eruptive activities on distant astronomical objects. Through several cases, we illustrate what we can learn from the TDS charts. Furthermore, we apply the TDS method to 74 flares equal to or greater than the M5.0 class, and reach the following statistical results. First, EUV peaks are always behind the soft X-raymore » (SXR) peaks and stronger flares tend to have faster cooling rates. There is a power-law correlation between the peak delay times and the cooling rates, suggesting a coherent cooling process of flares from SXR to EUV emissions. Second, there are two distinct temperature drift patterns, called Type I and Type II. For Type I flares, the enhanced emission drifts from high to low temperature like a quadrilateral, whereas for Type II flares the drift pattern looks like a triangle. Statistical analysis suggests that Type II flares are more impulsive than Type I flares. Third, for late-phase flares, the peak intensity ratio of the late phase to the main phase is roughly correlated with the flare class, and the flares with a strong late phase are all confined. We believe that the re-deposition of the energy carried by a flux rope, which unsuccessfully erupts out, into thermal emissions is responsible for the strong late phase found in a confined flare. Furthermore, we show the signatures of the flare thermodynamic process in the chromosphere and transition region in the TDS charts. These results provide new clues to advance our understanding of the thermodynamic processes of solar flares and associated solar eruptions, e.g., coronal mass ejections.« less
Ciccarese, Mariangela; Fabi, Alessandra; Moscetti, Luca; Cazzaniga, Maria Elena; Petrucelli, Luciana; Forcignanò, Rosachiara; Lupo, Laura Isabella; De Matteis, Elisabetta; Chiuri, Vincenzo Emanuele; Cairo, Giuseppe; Febbraro, Antonio; Giordano, Guido; Giampaglia, Marianna; Bilancia, Domenico; La Verde, Nicla; Maiello, Evaristo; Morritti, Maria; Giotta, Francesco; Lorusso, Vito; Latorre, Agnese; Scavelli, Claudio; Romito, Sante; Cusmai, Antonio; Palmiotti, Gennaro; Surico, Giammarco
2017-06-01
This retrospective analysis focused on the effect of treatment with EVE/EXE in a real-world population outside of clinical trials. We examined the efficacy of this combination in terms of PFS and RR related to dose intensity (5 mg daily versus 10 mg daily) and tolerability. 163 HER2-negative ER+/PgR+ ABC patients, treated with EVE/EXE from May 2011 to March 2016, were included in the analysis. The primary endpoints were the correlation between the daily dose and RR and PFS, as well as an evaluation of the tolerability of the combination. Secondary endpoints were RR, PFS, and OS according to the line of treatment. Patients were classified into three different groups, each with a different dose intensity of everolimus (A, B, C). RR was 29.8% (A), 27.8% (B) (p = 0.953), and not evaluable (C). PFS was 9 months (95% CI 7-11) (A), 10 months (95% CI 9-11) (B), and 5 months (95% CI 2-8) (C), p = 0.956. OS was 38 months (95% CI 24-38) (A), median not reached (B), and 13 months (95% CI 10-25) (C), p = 0.002. Adverse events were stomatitis 57.7% (11.0% grade 3-4), asthenia 46.0% (6.1% grade 3-4), hypercholesterolemia 46.0% (0.6% grade 3-4), and hyperglycemia 35.6% (5.5% grade 3-4). The main reason for discontinuation/interruption was grade 2-3 stomatitis. No correlation was found between dose intensity (5 vs. 10 mg labeled dose) and efficacy in terms of RR and PFS. The tolerability of the higher dose was poor in our experience, although this had no impact on efficacy.
2014 Summer Series - Laura Iraci - Up In the Air: Methane and Ozone Over California
2014-08-07
The Alpha Jet Atmospheric eXperiment (AJAX) at NASA Ames Research Center measures in-situ carbon dioxide, methane, and ozone concentrations in the Earth's atmosphere several times each month. The aircraft is stationed at Moffett Field and is outfitted with scientific instruments to measure trace gas concentrations and 3-D wind speeds. This talk will focus on recent observations over dairy operations, fossil fuel infrastructure, and wildfires.
2011-03-15
of emerging threats for in-garrison or deployed operations. Topics of interest include research in bio -surveillance, infectious disease, emerging...Saber Hussain, Laura Braydich-Stolle, Nicole Schaeublin, David Mattie (Presented by Dr. David Mattie ) Recent developments have generated a degree...Evaluation of Jet Fuel Inducted Hearing Loss in Rats 711th Human Performance Wing (HPW)/RHPA David Mattie , PhD Noise-induced hearing loss (NIHL
Assessing Air Force Investment and Opportunities in Information Superiority
1999-06-01
Jones, Rosanne Martin, and Pete Worden; Lieutenant Colonel Ann McLeod; Majors Karen Bridges, Randy Comer, Greg Rattray, and Laura Sakos; and Captain...far less vulnerable to information- hungry weapons.2 The leadership of the United States Air Force is wrestling the nature of the this new information...that are used describe representative information age organizational frameworks conducive to innovation—“the organization as a brain ” and the “garbage
ERIC Educational Resources Information Center
Colombo, Laura
2014-01-01
It is late at night, after working all day on her postdoctoral research Laura Colombo is trying to wind down while drawing and jotting down thoughts in her notebook. She is in the living room/office of her apartment in Buenos Aires, the city where she was born and left when she was 26 years old to pursue her graduate studies in the United States…
2015-12-01
CANCER THERAPY PRINCIPAL INVESTIGATOR: Dr. LAURA D. ATTARDI CONTRACTING ORGANIZATION: STANFORD UNIVERSITY MENLO PARK, CA 94025-3434 REPORT DATE...S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERStanford University 450 Serra Mall Stanford, CA 94305-2004 9...Generation of reporter lines in Arf-/- immortalized MEFs. As described in detail in the previous annual report, we utilized CRISPR /Cas9 targeting strategies
Return with Honor: Code of Conduct Training in the National Military Strategy Security Environment
2004-09-01
maximize the number of deaths and injuries among the most vulnerable civilians, such as children, women and the elderly… The terrorist leaders - who do...Return with Honor: Code of Conduct Training in the National Military Strategy Security Environment 6. AUTHOR(S) Major Laura M. Ryan 5. FUNDING NUMBERS ...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER
Salivary Platelet Activating Factor Levels in Periodontal Disease
1991-05-01
Factor Levels in Periodontal Disease 6. AUTHOR(S) Martha L. Garito, Major 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATO;N...ABSTRACT 98 0801 SALIVARY PLATELET ACTIVATING FACTOR LEVELS IN PERIODONTAL DISEASE A THESIS Presented to the Faculty of The University of Texas Graduate...B.S., D.M.D. San Antonio, Texas May 1991 SALIVARY PLATELET ACTIVATING FACTOR LEVELS IN PERIODONTAL DISEASE Martha Laura Gar’to APPROVED: - Supervising
Consolidating Air Force Maintenance Occupational Specialties
2016-01-01
Bill Gilbert . A number of colleagues at RAND, including John Drew, Laura Baldwin, Al Robbert, and Ray Conley, provided support during this effort...Massey, James M. Masters, Raymond A. Pyles, Ricardo Sanchez, Jerry M. Sollinger, Brent Thomas, Robert S. Tripp, and Ben D. Van Roo, Analysis of the Air...MG-872-AF, 2009), Tripp et al. (Robert S. Tripp, Ronald G. McGarvey, Ben D. Van Roo, James M. Masters and Jerry M. Sollinger. A Repair Network
STS-26 crewmembers participate in bench review at offsite Boeing Bldg
NASA Technical Reports Server (NTRS)
1988-01-01
STS-26 Discovery, Orbiter Vehicle (OV) 103, crewmembers participate in bench review at the offsite Boeing Building. Commander Frederick H. Hauck reviews a checklist of necessary supplies with Flight Equipment Processing engineer Laura E. Duvall. Pilot Richard O. Covey makes notations on checklist in background. Hygiene supplies (razors, deodorants, brushes, combs, etc.) are displayed on table behind Hauck. Photograph was taken by Keith Meyers of the NEW YORK TIMES.
Has the Dayton Peace Agreement Stopped Progress in Bosnia and Herzegovina?
2013-03-01
Headquarters Services , Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302...and lengthen economic recovery . 5 As a result of the atrocities of WWII, there was tremendous effort to define the treatment of non...Department of the Army, August 1, 2012), iii. 6 Laura Silber and Allan Little, Yugoslavia Death of a Nation (New York: Penguin, 1997), 29. 7 Richard
Improving the Cybersecurity of U.S. Air Force Military Systems Throughout Their Life Cycles
2015-01-01
James D. Powers, Elizabeth Bodine-Baron, Bernard Fox, Lauren Kendrick, Michael H. Powell Report Documentation Page Form ApprovedOMB No. 0704...Rational, Natural, and Open Systems, 3rd ed., Englewood Cliffs, N.J.: Prentice Hall, 1992. 61 Snyder, Don, Bernard Fox, Kristin F. Lynch, Raymond E...Conley, John A. Ausink, Laura Werber , William Shelton, Sarah A. Nowak, Michael R. Thirtle, and Albert A. Robbert, Assessment of the Air Force
Assessing Military Use of Training Areas Using a Geographic Information System
2010-05-01
potential impacts to sensitive cultural and natural resources with training activities. Purple amole – Fed. Threatened Arroyo Toad – Fed. Endangered Rock...purple amole o One incident (Nov. 2000) of Engineers driving off-road during wet season and outside dig-zone results in more stringent...Environmental Review process for the TA. Purple Amole (Chlorogalum purpureum var. purpureum) Fed. Threatened, CNPS 1B.1 Photo by Laura Ann Eliassen 6360
Hypersonic, nonequilibrium flow over the FIRE 2 forebody at 1634 sec
NASA Technical Reports Server (NTRS)
Chambers, Lin Hartung
1994-01-01
The numerical simulation of hypersonic flow in thermochemical nonequilibrium over the forebody of the FIRE 2 vehicle at 1634 sec in its trajectory is described. The simulation was executed on a Cray C90 with the program Langley Aerodynamic Upwind Relaxation Algorithm (LAURA) 4.0.2. Code setup procedures and sample results, including grid refinement studies, are discussed. This simulation relates to a study of radiative heating predictions on aerobrake type vehicles.
JPRS Report, Soviet Union: Political Affairs
1990-09-13
we have to do is to keep the existence of the chamber from being used as a way of setting the autonomous oblasts and krays of Russia in opposition...organizations. New Lithuanian Political Organizations 90UN2499A Vilnius LETUVOS RITAS in Russian 16-21 Jul 90 p 2 [Interview with Lauras Belinis and...the USDP is putting out a quarterly (a monthly) bulletin RADIATSIYAINITRATY to be edited by an academic, independent radiation-chemical center; j
The Sociology of the Gene: Genetics and Education on the Eve of the Biotech Century.
ERIC Educational Resources Information Center
Rifkin, Jeremy
1998-01-01
Researchers in molecular biology are discovering an increasing genetic basis for a wide range of mental diseases, moods, behaviors, and personality traits. Findings are creating the context for a new sociobiology favoring a genetic interpretation of human motivations and drives. Genetic engineering will give some people unprecedented power over…
On the Eve of Change: The Making of a Family Leave Policy at the University of Southern California.
ERIC Educational Resources Information Center
Reardon, Kathleen K.
1993-01-01
The University of Southern California's process for revising maternity leave to include fathers and adoptive parents is chronicled, including separate changes in staff and faculty policies. Proposed policies are outlined. Status of the proposed changes during a period of administrative change and future prospects for policy development are…
ERIC Educational Resources Information Center
Bouras, Christos; Triglianos, Vasileios; Tsiatsos, Thrasyvoulos
2014-01-01
Three dimensional Collaborative Virtual Environments are a powerful form of collaborative telecommunication applications, enabling the users to share a common three-dimensional space and interact with each other as well as with the environment surrounding them, in order to collaboratively solve problems or aid learning processes. Such an…
Breaking up with Deleuze: Desire and Valuing the Irreconcilable
ERIC Educational Resources Information Center
Tuck, Eve
2010-01-01
In this article, Eve Tuck grapples with Gilles Deleuze's conceptualization of desire, finding it simultaneously generative and unsatisfying. Recognizing that Deleuze will not "say" what Tuck wants him to say about desire--that it is smart, and constitutes expertise--Tuck reasons that there is only one thing she can do: break up with Deleuze. The…
2008-11-26
S126-E-012093 (27 Nov. 2008) --- Backdropped against a massive cloud cover, the aft portion of the Space Shuttle Endeavour, with the multi-purpose logistics module Leonardo in stow mode, was captured in a series of photographs by one of the STS-126 crewmembers on Nov. 27, Thanksgiving day, also the eve of departure from the International Space Station on Nov. 28.
2008-11-26
S126-E-012103 (27 Nov. 2008) --- --- Backdropped against the blackness of space, the aft portion of the Space Shuttle Endeavour, with the multi-purpose logistics module Leonardo in stow mode, was captured in a series of photographs by one of the STS-126 crewmembers on Nov. 27, Thanksgiving day, also the eve of departure from the International Space Station on Nov. 28.
Hilary Putnam Interviewed by Naoko Saito and Paul Standish
ERIC Educational Resources Information Center
Journal of Philosophy of Education, 2014
2014-01-01
The interview, which took place on the eve of the 2012 American presidential election, coincides with the publication of three major works by or about Hilary Putnam. It begins and ends with the topic of science, drawing attention to science's profound importance but also to its contemporary forms of distortion. It explores Putnam's…
Woodrow Wilson: Prophet of Peace. Teaching with Historic Places.
ERIC Educational Resources Information Center
Goehner, Thomas B.
This lesson describes President Woodrow Wilson's struggle with and his ultimate failure at achieving lasting world peace through the League of Nations. The lesson focuses on November 23, 1923, the eve of the fifth anniversary of the Armistice that concluded World War I, when a frail and ill Wilson was ready to deliver a commemorative address by…
Manifest Destiny and Competing Voices on the Eve of the Cherokee Removal
ERIC Educational Resources Information Center
Chandler, Prentice T.
2011-01-01
Manifest Destiny, the idea that Providence guided the conquest and settlement of North America, is one of the most contested ideas in American culture and history. One's opinion about this central aspect of American mythology depends heavily on one's point of view. Exploring westward expansion and the Cherokee Trail of Tears with primary sources…
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-16
... at the request of Fairplay Electric Cars, LLC (``Fairplay''), under procedures set forth at 19 CFR... Fairplay Electric Cars 743 Horizon Ct., Suite 333 Grand Junction, CO 81506 RE: Government Procurement... behalf of Fairplay Electric Cars, LLC (``Fairplay''), pursuant to subpart B of part 177 of the U.S...
Rice University: Building an Academic Center for Nonprofit Education
ERIC Educational Resources Information Center
Seaworth, Angela
2012-01-01
According to the author, the setting for their nonprofit education center was close to ideal: Support from a dean who cares deeply about nonprofit organizations; encouragement from the university and its renewed focus on reaching beyond its walls on the eve of its centennial; and a generous gift from alumni who have been affiliated with the…
The Y2K Problem: Will It Just Be Another New Year's Eve?
ERIC Educational Resources Information Center
Iwanowski, Jay
1998-01-01
Potential problems for college and university computing functions posed by arrival of the year 2000 (Y2K) are discussed, including arithmetic calculations and sorting functions based on two-digit year dates, embedding of two-digit dates in archival data, system coordination for data exchange, unique number generation, and leap year calculations. A…
75 FR 80717 - Safety Zone; Sacramento New Year's Eve, Fireworks Display, Sacramento, CA
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-23
... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-1079] RIN 1625... being available in the docket are part of docket USCG-2010-1079 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1079 in the ``Keyword'' box, and then clicking...
Adjuncts Fight Back over Academic Freedom
ERIC Educational Resources Information Center
Wilson, Robin
2008-01-01
Steven Bitterman was fired by his school after he offended his students for telling them that they could easily appreciate the biblical story of Adam and Eve if they considered it a myth. Several adjunct and full-time professors who work off the tenure track have been fired after saying something, as Mr. Bitterman did, that offended students or…
ERIC Educational Resources Information Center
Castro, Mary Garcia
This paper presents research on the immigration, employment, familial, and social experiences of Colombian women in New York City. The data discussed are derived from both a literature review and extensive interviews with Colombian women residing in the city during recent years. It is hypothesized that Colombian women's perceptions of their actual…
The Big Apple's Core: Exploring Manhattan
ERIC Educational Resources Information Center
Groce, Eric C.; Groce, Robin D.; Colby, Susan
2005-01-01
Children are exposed to a wide variety of images related to New York City through various media outlets. They may have seen glimpses of Manhattan by watching movies such as Spiderman or Stuart Little or by taking in annual television events such as the Macy's Thanksgiving Day Parade or the Times Square New Year's Eve celebration. Additionally,…
ERIC Educational Resources Information Center
Chu, Godwin C.
Focusing on economic development in the People's Republic of China beginning at the eve of the communist takeover, this monograph analyzes the ways and patterns in which mass media and interpersonal communication were used to change economically relevant social structures in the interclass confrontation and the part these patterns played in the…
Spill Sleuths: An Interdisciplinary Environmental Health Investigation
ERIC Educational Resources Information Center
Rudensey, Lyle; Whidden, Jeff
2005-01-01
"We are on the eve of total contamination," said an eighth grade "toxicologist" at a mock town meeting at Mount Baker Middle School in Mount Vernon, Washington. The meeting was the culmination of a month-long investigation by students to determine why some of the townspeople were getting sick. During the unit, students used skills from several…
Mike O’Callaghan Federal Medical Center Campus Environmental Assessment
2012-03-01
and therefore is protected under the Endangered Species Act (ESA). The western burrowing owl (Athene cunicularia) is a former USFWS C- 2 species and...JVanHavel@dot . state . nv.us> ; keiba.crear@snwa.com; LANGSTON@ClarkCountyNV. gov; ~arry . Tamashiro@ lvvwd. com <mailto : Larry . Tamashi! r o@lvvwd...Wardlaw; JVanHavel @dot .state.nv .us; keiba . c rear@snwa . com; Rodney Langston; Larry . Tamashiro@l vvwd.com; laura. j a cobsen@lvvwd . com