Protective Effects of the Launch/Entry Suit (LES) and the Liquid Cooling Garment(LCG) During Re-entry and Landing After Spaceflight

NASA Technical Reports Server (NTRS)

Perez, Sondra A.; Charles, John B.; Fortner, G. William; Hurst, Victor, IV; Meck, Janice V.

2002-01-01

Heart rate and arterial pressure were measured during shuttle re-entry, landing and initial standing in crewmembers with and without inflated anti-g suits and with and without liquid cooling garments (LCG). Preflight, three measurements were obtained seated, then standing. Prior to and during re-entry, arterial pressure and heart rate were measured every five minutes until wheels stop (WS). Then crewmembers initiated three seated and three standing measurements. In subjects without inflated anti-g suits, SBP and DBP were significantly lower during preflight standing (P = 0.006; P = 0.001 respectively) and at touchdown (TD) (P = 0.001; P = 0.003 respectively); standing SBP was significantly lower after WS. on-LeG users developed significantly higher heart rates during re-entry (P = 0.029, maxG; P = 0.05, TD; P = 0.02, post-WS seated; P = 0.01, post-WS standing) than LCG users. Our data suggest that the anti-g suit is effective, but the combined anti-g suit with LCG is more effective.

Command-line cellular electrophysiology for conventional and real-time closed-loop experiments.

PubMed

Linaro, Daniele; Couto, João; Giugliano, Michele

2014-06-15

Current software tools for electrophysiological experiments are limited in flexibility and rarely offer adequate support for advanced techniques such as dynamic clamp and hybrid experiments, which are therefore limited to laboratories with a significant expertise in neuroinformatics. We have developed lcg, a software suite based on a command-line interface (CLI) that allows performing both standard and advanced electrophysiological experiments. Stimulation protocols for classical voltage and current clamp experiments are defined by a concise and flexible meta description that allows representing complex waveforms as a piece-wise parametric decomposition of elementary sub-waveforms, abstracting the stimulation hardware. To perform complex experiments lcg provides a set of elementary building blocks that can be interconnected to yield a large variety of experimental paradigms. We present various cellular electrophysiological experiments in which lcg has been employed, ranging from the automated application of current clamp protocols for characterizing basic electrophysiological properties of neurons, to dynamic clamp, response clamp, and hybrid experiments. We finally show how the scripting capabilities behind a CLI are suited for integrating experimental trials into complex workflows, where actual experiment, online data analysis and computational modeling seamlessly integrate. We compare lcg with two open source toolboxes, RTXI and RELACS. We believe that lcg will greatly contribute to the standardization and reproducibility of both simple and complex experiments. Additionally, on the long run the increased efficiency due to a CLI will prove a great benefit for the experimental community. Copyright © 2014 Elsevier B.V. All rights reserved.

Microbial communities of the Lemon Creek Glacier show subtle structural variation yet stable phylogenetic composition over space and time

PubMed Central

Sheik, Cody S.; Stevenson, Emily I.; Den Uyl, Paul A.; Arendt, Carli A.; Aciego, Sarah M.; Dick, Gregory J.

2015-01-01

Glaciers are geologically important yet transient ecosystems that support diverse, biogeochemically significant microbial communities. During the melt season glaciers undergo dramatic physical, geochemical, and biological changes that exert great influence on downstream biogeochemical cycles. Thus, we sought to understand the temporal melt-season dynamics of microbial communities and associated geochemistry at the terminus of Lemon Creek Glacier (LCG) in coastal southern Alaska. Due to late season snowfall, sampling of LCG occurred in three interconnected areas: proglacial Lake Thomas, the lower glacial outflow stream, and the glacier’s terminus. LCG associated microbial communities were phylogenetically diverse and varied by sampling location. However, Betaproteobacteria, Alphaproteobacteria, and Bacteroidetes dominated communities at all sampling locations. Strict anaerobic groups such as methanogens, SR1, and OP11 were also recovered from glacier outflows, indicating anoxic conditions in at least some portions of the LCG subglacial environment. Microbial community structure was significantly correlated with sampling location and sodium concentrations. Microbial communities sampled from terminus outflow waters exhibited day-to-day fluctuation in taxonomy and phylogenetic similarity. However, these communities were not significantly different from randomly constructed communities from all three sites. These results indicate that glacial outflows share a large proportion of phylogenetic overlap with downstream environments and that the observed significant shifts in community structure are driven by changes in relative abundance of different taxa, and not complete restructuring of communities. We conclude that LCG glacial discharge hosts a diverse and relatively stable microbiome that shifts at fine taxonomic scales in response to geochemistry and likely water residence time. PMID:26042114

Liquid Cooling Garment Technology Transfer: A Biomedical Case Study

NASA Technical Reports Server (NTRS)

Ku, Yu-Tsuan E.; Montgomery, Leslie D.; Lomax, W. Curtis; Webbon, Bruce W.

1995-01-01

Liquid cooling garments (LCGs) are routinely used to remove the body heat generated in a space-suit during extravehicular activity (EVA). Garments based upon LCG design have been used in various biomedical situations. The objectives of this investigation is to describe one recent LCG application to provide relief of the pain associated with peripheral neuritis and to report the physiologic changes responsible for this relief.

Scrambled Sobol Sequences via Permutation

DTIC Science & Technology

2009-01-01

LCG LCG64 LFG MLFG PMLCG Sobol Scrambler PermutationScrambler LinearScrambler <<uses>> PermuationFactory StaticFactory DynamicFactory <<uses>> Figure 3...Phy., 19:252–256, 1979. [2] Emanouil I. Atanassov. A new efficient algorithm for generating the scrambled sobol ’ sequence. In NMA ’02: Revised Papers...Deidre W.Evan, and Micheal Mascagni. On the scrambled sobol sequence. In ICCS2005, pages 775–782, 2005. [7] Richard Durstenfeld. Algorithm 235: Random

Coronary heart disease index based on longitudinal electrocardiography

NASA Technical Reports Server (NTRS)

Townsend, J. C.; Cronin, J. P.

1977-01-01

A coronary heart disease index was developed from longitudinal ECG (LCG) tracings to serve as a cardiac health measure in studies of working and, essentially, asymptomatic populations, such as pilots and executives. For a given subject, the index consisted of a composite score based on the presence of LCG aberrations and weighted values previously assigned to them. The index was validated by correlating it with the known presence or absence of CHD as determined by a complete physical examination, including treadmill, resting ECG, and risk factor information. The validating sample consisted of 111 subjects drawn by a stratified-random procedure from 5000 available case histories. The CHD index was found to be significantly more valid as a sole indicator of CHD than the LCG without the use of the index. The index consistently produced higher validity coefficients in identifying CHD than did treadmill testing, resting ECG, or risk factor analysis.

[Antagonistic effect of the insertion/deletion (HpaI) polymorphism in the regulatory part of the gene for apolipoprotein CI in children with high and low levels of cholesterol].

PubMed

Hubácek, J A; Pistulková, H; Skodová, Z; Lánská, V; Poledne, R

2004-01-01

High plasma lipids are one of the risk factor of atherosclerosis. Both environmental (diet, physic activity) and genetic factors have been implicated in the development of hyperlipidaemia. Apolipoprotein (apo) CI plays an important role in plasma cholesterol and triglycerides transport by VLDL particles. The aim of the study was to establish the role of the insertion/deletion polymorphism in apoCI gene in the determination of plasma lipids in children. Using PCR and restriction analysis (HpaI) we have measured I/D polymorphism in APOCI gene in two groups of children selected from opposite ends of the cholesterol distribution curve of 2000 children. Eighty-two children in high-(HCG) and eighty-six children in low-(LCG) cholesterolemic groups participated on the study. No significant difference was found in the frequencies of the APOCI genotypes or alleles between HCG vs. LCG. Association between LDL cholesterol and genotypes within the LCG was found--the D/D homozygotes have higher lipid level compared to the others (p < 0.05). In LCG opposite, but insignificant (p = 0.09) trend was observed. The widespread I/D polymorphism in the gene for APOCI determines the plasma lipid levels in childhood and it could become another important genetic marker that plays a role in the genetic determination of cholesterolemia.

Landscape community genomics: understanding eco-evolutionary processes in complex environments

USGS Publications Warehouse

Hand, Brian K.; Lowe, Winsor H.; Kovach, Ryan P.; Muhlfeld, Clint C.; Luikart, Gordon

2015-01-01

Extrinsic factors influencing evolutionary processes are often categorically lumped into interactions that are environmentally (e.g., climate, landscape) or community-driven, with little consideration of the overlap or influence of one on the other. However, genomic variation is strongly influenced by complex and dynamic interactions between environmental and community effects. Failure to consider both effects on evolutionary dynamics simultaneously can lead to incomplete, spurious, or erroneous conclusions about the mechanisms driving genomic variation. We highlight the need for a landscape community genomics (LCG) framework to help to motivate and challenge scientists in diverse fields to consider a more holistic, interdisciplinary perspective on the genomic evolution of multi-species communities in complex environments.

Device for diagnosis and treatment of impairments on binocular vision and stereopsis

NASA Astrophysics Data System (ADS)

Bahn, Jieun; Choi, Yong-Jin; Son, Jung-Young; Kodratiev, N. V.; Elkhov, Victor A.; Ovechkis, Yuri N.; Chung, Chan-sup

2001-06-01

Strabismus and amblyopia are two main impairments of our visual system, which are responsible for the loss of stereovision. A device is developed for diagnosis and treatment of strabismus and amblyopia, and for training and developing stereopsis. This device is composed of a liquid crystal glasses (LCG), electronics for driving LCG and synchronizing with an IBM PC, and a special software. The software contains specially designed patterns and graphics for enabling to train and develop stereopsis, and do objective measurement of some stereoscopic vision parameters such as horizontal and vertical phoria, fusion, fixation disparity, and stereoscopic visual threshold.

Design and testing of a liquid cooled garment for hot environments.

PubMed

Guo, Tinghui; Shang, Bofeng; Duan, Bin; Luo, Xiaobing

2015-01-01

Liquid cooled garments (LCGs) are considered a viable method to protect individuals from hyperthermia and heat-related illness when working in thermally stressful environments. While the concept of LCGs was proposed over 50 years ago, the design and testing of these systems is undeveloped and stands in need of further study. In this study, a detailed heat transfer model of LCG in a hot environment was built to analyze the effects of different factors on the LCG performance, and to identify the main limitations to achieve maximum performance. An LCG prototype was designed and fabricated. Series of tests were done by a modified thermal manikin method to validate the heat transfer model and to evaluate the thermal properties. Both experimental and predicted results show that the heat flux components match the heat balance equation with an error of less than 10% at different flowrate. Thermal resistance analysis also manifests that the thermal resistance between the cooling water and the ambient (R2) is more sensitive to the flowrate than to the one between the skin surface and the cooling water (R1). When the flowrate increased from 225 to 544 mL/min, R2 decreased from 0.5 to 0.3 °C m(2)/W while R1 almost remained constant. A specific duration time was proposed to assess the durability and an optimized value of 1.68 h/kg was found according to the heat transfer model. The present heat transfer model and specific duration time concept could be used to optimize and evaluate this kind of LCG respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Influence of body heat content on hand function during prolonged cold exposures.

PubMed

Flouris, A D; Cheung, S S; Fowles, J R; Kruisselbrink, L D; Westwood, D A; Carrillo, A E; Murphy, R J L

2006-09-01

We examined the influence of 1) prior increase [preheating (PHT)], 2) increase throughout [heating (HT)], and 3) no increase [control (Con)] of body heat content (H(b)) on neuromuscular function and manual dexterity of the hands during a 130-min exposure to -20 degrees C (coldEx). Ten volunteers randomly underwent three passive coldEx, incorporating a 10-min moderate-exercise period at the 65th min while wearing a liquid conditioning garment (LCG) and military arctic clothing. In PHT, 50 degrees C water was circulated in the LCG before coldEx until core temperature was increased by 0.5 degrees C. In HT, participants regulated the inlet LCG water temperature throughout coldEx to subjective comfort, while the LCG was not operating in Con. Thermal comfort, rectal temperature, mean skin temperature, mean finger temperature (T(fing)), change in H(b) (DeltaH(b)), rate of body heat storage, Purdue pegboard test, finger tapping, handgrip, maximum voluntary contraction, and evoked twitch force of the first dorsal interosseus muscle were recorded. Results demonstrated that, unlike in HT and PHT, thermal comfort, rectal temperature, mean skin temperature, twitch force, maximum voluntary contraction, and finger tapping declined significantly in Con. In contrast, T(fing) and Purdue pegboard test remained constant only in HT. Generalized estimating equations demonstrated that DeltaH(b) and T(fing) were associated over time with hand function, whereas no significant association was detected for rate of body heat storage. It is concluded that increasing H(b) not only throughout but also before a coldEx is effective in maintaining hand function. In addition, we found that the best indicator of hand function is DeltaH(b) followed by T(fing).

Thermoregulatory and Orthostatic Responses to Wearing the Advanced Crew Escape Suit

NASA Technical Reports Server (NTRS)

Lee, Stuart M. C.; Jacobs, Tamara N.; McDaniel, Angela; Schneider, Suzanne M.

2006-01-01

Current NASA flight rules limit the maximum cabin temperature (23.9 C) during re-entry and landing to protect crewmembers from heat stress while wearing the Advanced Crew Escape Suit (ACES) and Liquid Cooling Garment (LCG). The primary purpose of this ground-based project was to determine whether the LCG could provide adequate cooling if ambient temperature reached 26.7 "C. The secondary objective was to determine whether there would be a graded effect of ambient temperature profiles with maximum temperatures of 23.9 (LO), 26.7 (MPD), and 29.4 C (HI). METHODS: Eight subjects underwent a 5-h temperature profile (22.8,26.7 C) in an environmental chamber while wearing the ACES and LCG. Subjects controlled the amount of cooling provided by the LCG. Core (T(sub core)),skin temperatures (T(sub sk)) and heart rate (HR) were measured every 15-min. A 10-minute stand test was administered pre- and post-chamber. Additionally, 4 subjects underwent the three 5-h temperature profiles (LO, MID, and HI) with the same measurements. RESULTS: In the 8 subjects completing the MID profile, T(sub core), and T(sub sk) decreased from the start' to the end of the chamber stay. Subjects completed the stand test without signs of orthostatic intolerance. In the 4 subjects who underwent all 3 profiles, there was no discernible pattern in T(sub core), T(sub sk), and HR responses across the temperature profiles. CONCLUSIONS: In the range of temperatures tested, subjects were able to sufficiently utilize the self-selected cooling to avoid any potential deleterious effects of wearing the ACES. However, these subjects were not microgravity exposed, which has been suggested to impair thermoregulation.

Liquid disinfecting and sterilization reprocessors used for flexible endoscopes.

PubMed

1994-06-01

In this issue, we evaluate three liquid disinfecting flexible endoscope reprocessors that can be used with a user-supplied liquid chemical germicide (LCG), primarily for high-level disinfection (HLD). Applying most of the same criteria and test methods, we also evaluated a fourth unit, presented separately, that is marketed as a liquid sterilizing reprocessor and must be used with manufacturer-supplied, single-use containers of LCG. Although the sterilizing unit can be used for rigid endoscopes, surgical instruments, and endoscopic accessories, we evaluated its application to the reprocessing of only flexible endoscopes. Our ratings are based on the following: (1) basic performance, such as compatibility with several different types of endoscopes and LCGs, inclusion of all essential reprocessing phases, and exposure of all endoscope surfaces to the LCG and rinse water; (2) safety, such as ensuring that essential reprocessing phases cannot be skipped or omitted, that personnel exposure to LCG vapors is minimized, and that the reprocessor is unlikely to contaminate the endoscope during reprocessing; and (3) human factors design, such as ease of use and installation. We did not perform microbiological testing to confirm HLD or sterilization by any of the evaluated reprocessors because, with a suitably clean endoscope that is in good condition, no evidence indicates that the LCGs used would not be effective on the surfaces that they contact; also, the results would be unique to the two flexible endoscopes that we used for our testing. We rated all four reprocessors Conditionally Acceptable. The units are Acceptable on the condition that users understand that they cannot be used to process the elevator cable channel of side-viewing duodenoscopes; additional conditions apply only to the liquid disinfecting units. However, if the conditions are met, all four units reduce the likelihood of using a contaminated endoscope on a patient and reduce personnel exposure to the LCG. Selection of a unit will be based on the needs and preferences of the individual healthcare facility. Our ratings also assume that these units will be used according to the manufacturers' instructions and the endoscope's operator's manual. Note that, although the evaluated liquid disinfecting units provide detergent-flushing, post-detergent water-rinse, and post-detergent water-rinse-removal phases, manual cleaning of endoscopes before automatic reprocessing is essential, regardless of which reprocessor is used.

An improved thermoregulatory model for cooling garment applications with transient metabolic rates

NASA Astrophysics Data System (ADS)

Westin, Johan K.

Current state-of-the-art thermoregulatory models do not predict body temperatures with the accuracies that are required for the development of automatic cooling control in liquid cooling garment (LCG) systems. Automatic cooling control would be beneficial in a variety of space, aviation, military, and industrial environments for optimizing cooling efficiency, for making LCGs as portable and practical as possible, for alleviating the individual from manual cooling control, and for improving thermal comfort and cognitive performance. In this study, we adopt the Fiala thermoregulatory model, which has previously demonstrated state-of-the-art predictive abilities in air environments, for use in LCG environments. We validate the numerical formulation with analytical solutions to the bioheat equation, and find our model to be accurate and stable with a variety of different grid configurations. We then compare the thermoregulatory model's tissue temperature predictions with experimental data where individuals, equipped with an LCG, exercise according to a 700 W rectangular type activity schedule. The root mean square (RMS) deviation between the model response and the mean experimental group response is 0.16°C for the rectal temperature and 0.70°C for the mean skin temperature, which is within state-of-the-art variations. However, with a mean absolute body heat storage error 3¯ BHS of 9.7 W˙h, the model fails to satisfy the +/-6.5 W˙h accuracy that is required for the automatic LCG cooling control development. In order to improve model predictions, we modify the blood flow dynamics of the thermoregulatory model. Instead of using step responses to changing requirements, we introduce exponential responses to the muscle blood flow and the vasoconstriction command. We find that such modifications have an insignificant effect on temperature predictions. However, a new vasoconstriction dependency, i.e. the rate of change of hypothalamus temperature weighted by the hypothalamus error signal (DeltaThy˙ dThy/dt), proves to be an important signal that governs the thermoregulatory response during conditions of simultaneously increasing core and decreasing skin temperatures, which is a common scenario in LCG environments. With the new ?DeltaThy˙dThy /dt dependency in the vasoconstriction command, the 3¯ BHS for the exercise period is reduced by 59% (from 12.9 W˙h to 5.2 W˙h). Even though the new 3¯ BHS of 5.8 W˙h for the total activity schedule is within the target accuracy of +/-6.5 W˙h, 3¯ BHS fails to stay within the target accuracy during the entire activity schedule. With additional improvements to the central blood pool formulation, the LCG boundary condition, and the agreement between model set-points and actual experimental initial conditions, it seems possible to achieve the strict accuracy that is needed for automatic cooling control development.

Ice Pack Heat Sink Subsystem - Phase I. [astronaut liquid cooling garment design and testing

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.

1973-01-01

This paper describes the design and test at one-g of a functional laboratory model (non-flight) Ice Pack Heat Sink Subsystem to be used eventually for astronaut cooling during manned space missions. In normal use, excess heat in the liquid cooling garment (LCG) coolant is transferred to a reusable/regenerable ice pack heat sink. For emergency operation, or for extension of extravehicular activity mission time after all the ice has melted, water from the ice pack is boiled to vacuum, thereby continuing to remove heat from the LCG coolant. This subsystem incorporates a quick connect/disconnect thermal interface between the ice pack heat sink and the subsystem heat exchanger.

Ice pack heat sink subsystem - Phase 1, Volume 1

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.

1973-01-01

The design, development, fabrication, and test at one-g of a functional laboratory model (non-flight) ice pack heat sink subsystem to be used eventually for astronaut cooling during manned space missions are discussed. In normal use, excess heat in the liquid cooling garment (LCG) coolant is transferred to a reusable/regenerable ice pack heat sink. For emergency operation, or for extension of extravehicular activity mission time after all the ice has melted, water from the ice pack is boiled to vacuum, thereby continuing to remove heat from the LCG coolant. This subsystem incorporates a quick connect/disconnect thermal interface between the ice pack heat sink and the subsystem heat exchanger.

Cardiovascular effects of anti-G suit and cooling garment during space shuttle re-entry and landing.

PubMed

Perez, Sondra A; Charles, John B; Fortner, G William; Hurst, Victor; Meck, Janice V

2003-07-01

Many cardiovascular changes associated with spaceflight reduce the ability of the cardiovascular system to oppose gravity on return to Earth, leaving astronauts susceptible to orthostatic hypotension during re-entry and landing. Consequently, an anti-G suit was developed to protect arterial pressure during re-entry. A liquid cooling garment (LCG) was then needed to alleviate the thermal stress resulting from use of the launch and entry suit. We studied 34 astronauts on 22 flights (4-16 d). Subjects were studied 10 d before launch and on landing day. Preflight, crewmembers were suited with their anti-G suits set to the intended inflation for re-entry. Three consecutive measurements of heart rate and arterial pressure were obtained while seated and then again while standing. Three subjects who inflated the anti-G suits also donned the LCG for landing. Arterial pressure and heart rate were measured every 5 min during the de-orbit maneuver, through maximum G-loading (max-G) and touch down (TD). After TD, crew-members again initiated three seated measurements followed by three standing measurements. Astronauts with inflated anti-G suits had higher arterial pressure than those who did not have inflated anti-G suits during re-entry and landing (133.1 +/- 2.5/76.1 +/- 2.1 vs. 128.3 +/- 4.2/79.3 +/- 2.9, de-orbit; 157.3 +/- 4.5/102.1 +/- 3.6 vs. 145.2 +/- 10.5/95.7 + 5.5, max-G; 159.6 +/- 3.9/103.7 +/- 3.3 vs. 134.1 +/- 5.1/85.7 +/- 3.1, TD). In the group with inflated anti-G suits, those who also wore the LCG exhibited significantly lower heart rates than those who did not (75.7 +/- 11.5 vs. 86.5 +/- 6.2, de-orbit; 79.5 +/- 24.8 vs. 112.1 +/- 8.7, max-G; 84.7 +/- 8.0 vs. 110.5 +/- 7.9, TD). The anti-G suit is effective in supporting arterial pressure. The addition of the LCG lowers heart rate during re-entry.

Cardiovascular effects of anti-G suit and cooling garment during space shuttle re-entry and landing

NASA Technical Reports Server (NTRS)

Perez, Sondra A.; Charles, John B.; Fortner, G. William; Hurst, Victor 4th; Meck, Janice V.

2003-01-01

BACKGROUND: Many cardiovascular changes associated with spaceflight reduce the ability of the cardiovascular system to oppose gravity on return to Earth, leaving astronauts susceptible to orthostatic hypotension during re-entry and landing. Consequently, an anti-G suit was developed to protect arterial pressure during re-entry. A liquid cooling garment (LCG) was then needed to alleviate the thermal stress resulting from use of the launch and entry suit. METHODS: We studied 34 astronauts on 22 flights (4-16 d). Subjects were studied 10 d before launch and on landing day. Preflight, crewmembers were suited with their anti-G suits set to the intended inflation for re-entry. Three consecutive measurements of heart rate and arterial pressure were obtained while seated and then again while standing. Three subjects who inflated the anti-G suits also donned the LCG for landing. Arterial pressure and heart rate were measured every 5 min during the de-orbit maneuver, through maximum G-loading (max-G) and touch down (TD). After TD, crew-members again initiated three seated measurements followed by three standing measurements. RESULTS: Astronauts with inflated anti-G suits had higher arterial pressure than those who did not have inflated anti-G suits during re-entry and landing (133.1 +/- 2.5/76.1 +/- 2.1 vs. 128.3 +/- 4.2/79.3 +/- 2.9, de-orbit; 157.3 +/- 4.5/102.1 +/- 3.6 vs. 145.2 +/- 10.5/95.7 + 5.5, max-G; 159.6 +/- 3.9/103.7 +/- 3.3 vs. 134.1 +/- 5.1/85.7 +/- 3.1, TD). In the group with inflated anti-G suits, those who also wore the LCG exhibited significantly lower heart rates than those who did not (75.7 +/- 11.5 vs. 86.5 +/- 6.2, de-orbit; 79.5 +/- 24.8 vs. 112.1 +/- 8.7, max-G; 84.7 +/- 8.0 vs. 110.5 +/- 7.9, TD). CONCLUSIONS: The anti-G suit is effective in supporting arterial pressure. The addition of the LCG lowers heart rate during re-entry.

LHCb experience with LFC replication

NASA Astrophysics Data System (ADS)

Bonifazi, F.; Carbone, A.; Perez, E. D.; D'Apice, A.; dell'Agnello, L.; Duellmann, D.; Girone, M.; Re, G. L.; Martelli, B.; Peco, G.; Ricci, P. P.; Sapunenko, V.; Vagnoni, V.; Vitlacil, D.

2008-07-01

Database replication is a key topic in the framework of the LHC Computing Grid to allow processing of data in a distributed environment. In particular, the LHCb computing model relies on the LHC File Catalog, i.e. a database which stores information about files spread across the GRID, their logical names and the physical locations of all the replicas. The LHCb computing model requires the LFC to be replicated at Tier-1s. The LCG 3D project deals with the database replication issue and provides a replication service based on Oracle Streams technology. This paper describes the deployment of the LHC File Catalog replication to the INFN National Center for Telematics and Informatics (CNAF) and to other LHCb Tier-1 sites. We performed stress tests designed to evaluate any delay in the propagation of the streams and the scalability of the system. The tests show the robustness of the replica implementation with performance going much beyond the LHCb requirements.

Ice pack heat sink subsystem, phase 2. [astronaut life support cooling system

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.; Kellner, J. D.

1975-01-01

The report describes the design, development, fabrication, and test at one gravity of a prototype ice pack heat sink subsystem to be used eventually for astronaut cooling during manned space missions; the investigation of thermal storage material with the objective of uncovering materials with heats of fusion and/or solution in the range of 300 Btu/lb (700 kilojoules/kilogram); and the planned procedure for implementing an ice pack heat sink subsystem flight experiment. In normal use, excess heat in the liquid cooling garment (LCG) coolant is transferred to a reusable/regenerable ice pack heat sink. For emergency operation, or for extension of extravehicular activity mission time after all the ice has melted, water from the ice pack is boiled to vacuum, thereby continuing to remove heat from the LCG coolant. This subsystem incorporates a quick disconnect thermal interface between the ice pack heat sink and the subsystem heat exchanger.

Industrial and biomedical use of aerospace personal cooling garments

NASA Technical Reports Server (NTRS)

Williams, B. A.; Mcewen, G. N., Jr.; Montgomery, L. D.; Elkins, W. E.

1975-01-01

Liquid-cooled garments (LCG) have been developed which utilize liquid-cooled modules rather than the network of tygon tubing typical of Apollo LCG's. The ultra-thin, heat-sealed, polyurethane modules are situated over the body to cover 50 percent of the body surface area with special emphasis on the 'working' muscles and the head-neck area. These garments are being designed specifically for industrial and biomedical uses, such as: a head-neck cooling system which is being tested for race-car drivers, tractor drivers, truck drivers, or a head-neck cooling system tested for the reduction of the scalp hair loss which normally accompanies cancer treatments. A combined head-neck and thorax unit is being developed for use during mine distaster rescue operations, and for other hazardous hot applications. Finally applications for head-neck and partitional cooling are anticipated for military pilots, tank drivers, and heavy equipment operations.

Regenerable non-venting cooler for protective suit

NASA Technical Reports Server (NTRS)

Roebelen, Jr., George J. (Inventor); Bayes, Stephen A. (Inventor)

1992-01-01

A life support back pack 14 for use during extravehicular activity in space incorporates a cooling apparatus 20 comprised of five panels 22 each of which include in layered fashion a LCG coolant heat exchange coil 32, a heat distribution plate 42, and a heat dissipation module 50A or 50B having an outer radiator surface 52. Each module 50A houses a first phase change material 55A, for example hexadecane paraffin, and each module 50B houses a second phase change material 55B, for example tetradecane paraffin, which has a phase change temperature which is less than the phase change temperature of the first phase change material 55A. The cooling apparatus 20 is equipped with a coolant heat exchange circuit provided with mode selection valves 84 and 86 which are operated by a controller 88 to selectively direct the LCG coolant to be cooled through the cooling apparatus in one of three operating modes.

[Polymorphism in the regulatory part of the cholesterol 7 alpha hydroxylase gene in children with high and low levels of cholesterol].

PubMed

Hubácek, J A; Pistulková, H; Skodová, Z; Lánská, V; Poledne, R

2003-01-01

High plasma cholesterol is one of the risk factors of atherosclerosis. Both environmental (diet, physic activity) and genetic factors have been concerned in the development of hypercholesterolemia. Cholesterol 7 alpha hydroxylase (CYP-7A1) is a key enzyme in the bile acid synthesis and it plays an important role in cholesterol catabolism. The aim of the study was to establish the role of A-204-->C polymorphism in CYP-7A1 gene in plasma lipid determination in children. Using PCR and restriction analysis (BsaI) we have measured A-204-->C polymorphism in CYP-7A1 gene in two groups of children selected from opposite ends of the cholesterol distribution curve of 2000 children. Eighty-two children in high- (HCG) and eighty-six children in low- (LCG) cholesterolemic groups participated in the study. No significant difference was found in the frequencies of the genotypes or alleles of the A-204-->C polymorphism in the CYP-7A1 gene between HCG and LCG. In HCG, C/C-204 homozygotes have the highest and A/A homozygotes the lowest levels of LDL-cholesterol (4.21 +/- 0.68 mmol/l vers. 3.69 +/- 0.60 mmol/l, p < 0.05). No associations between lipid parameters and genotypes within the LCG group were found. The A-204-->C polymorphism in the gene for CYP-7A1 is not the major determinant of plasma lipid levels in childhood. Its impact is expressed only on high cholesterol background.

Acute toxicity of three fire-retardant and two fire-suppressant foam formulations to the early life stages of rainbow trout (Oncorhynchus mykiss)

USGS Publications Warehouse

Gaikowski, Mark P.; Hamilton, Steven J.; Buhl, Kevin J.; McDonald, Susan F.; Summers, Cliff H.; Linder, G.; Krest, S.; Sparling, D.; Little, E.

1996-01-01

Laboratory studies were conducted with five early life stages of rainbow trout, Oncorhynchus mykiss, to determine the acute toxicities of five fire-fighting chemical formulations in standardized soft and hard water. Eyed egg, embryo–larvae, swim-up fry, and 60- and 90-d posthatch juveniles were exposed to three fire retardants (Fire-Trol LCG-R, Fire-Trol GTS-R, and Phos-Chek D75-F) and two fire-suppressant foams (Phos-Chek WD-881 and Silv-Ex). Swim-up fry were generally the most sensitive life stage, whereas the eyed-egg was the least sensitive. Toxicity of fire-fighting formulations was greater in hard water than in soft water for all life stages tested with Fire-Trol GTS-R and Silv-Ex and for 90-d-old juveniles tested with Fire-Trol LCG-R. The fire-suppressant foams were more toxic than the fire retardants. The 96-h median lethal concentrations (LC50s) were ranked from the most toxic to the least toxic formulation as follows (ranges are the lowest and highest 96-h LC50 calculated for each formulation): Phos-Chek WD-881 (11–44 mg/L), Silv-Ex (11–78 mg/L), Phos-Chek D75-F (218–>3,600 mg/L), Fire-Trol GTS-R (207–>6,000 mg/L), and Fire-Trol LCG-R (872–>10,000 mg/L). Toxicity values suggest that accidental entry of fire-fighting chemicals into aquatic environments could adversely affect fish populations.

Acute oral toxicities of wildland fire control chemicals to birds

USGS Publications Warehouse

Vyas, N.B.; Spann, J.W.; Hill, E.F.

2009-01-01

Wildland fire control chemicals are released into the environment by aerial and ground applications to manage rangeland, grassland, and forest fires. Acute oral 24 h median lethal dosages (LD50) for three fire retardants (Fire-Trol GTS-R?, Phos-Chek D-75F?, and Fire-Trol LCG-R?) and two Class A fire suppressant foams (Silv-Ex? and Phos-Chek WD881?) were estimated for northern bobwhites, Colinus virginianus, American kestrels, Falco sparverius, and red-winged blackbirds, Agelaius phoeniceus. The LD50s of all chemicals for the bobwhites and red-winged blackbirds and for kestrels dosed with Phos-Chek WD881? and Silv-Ex? were above the predetermined 2000 mg chemical/kg body mass regulatory limit criteria for acute oral toxicity. The LD50s were not quantifiable for kestrels dosed with Fire-Trol GTS-R?, Phos-Chek D-75F?, and Fire-Trol LCG-R? because of the number of birds which regurgitated the dosage. These chemicals appear to be of comparatively low order of acute oral toxicity to the avian species tested.

Acute toxicity of fire control chemicals to Daphnia magna(Straus) and Selenastrum capricornutum(Printz)

USGS Publications Warehouse

McDonald, Susan F.; Hamilton, Steven J.; Buhl, Kevin J.; Heisinger, James F.

1996-01-01

Acute toxicity tests were conducted exposingDaphnia magnaStraus (daphnid) in soft and hard reconstituted waters (hardness 42 and 162 mg/liter as CaCO3, respectively), andSelenastrum capricornutumPrintz (algae) in ASTM algal assay medium (hardness 15 mg/liter as CaCO3) to fire retardants Fire-Trol GTS-R, Fire-Trol LCG-R, and Phos-Chek D75-F, and foam suppressants Phos-Chek WD-881 and Silv-Ex. The chemicals were slightly toxic to practically harmless to daphnids and moderately toxic to algae. Water quality did not consistently alter the toxicity of the test chemicals to daphnids. The most toxic chemical to daphnids was Silv-Ex (48-hr EC507 mg/liter in soft and hard waters), whereas the least toxic chemical to daphnids was Fire-Trol LCG-R (48-hr EC50848 mg/liter in soft water, 813 mg/liter in hard water). The most toxic chemical to algae was Fire-Trol LCG-R (96-hr IC5010 mg/liter), and the least toxic chemical was Phos-Chek D75-F (96-hr IC5079 mg/liter). Un-ionized ammonia concentrations near the EC50or IC50value in tests with the Fire-Trol compounds were frequently equal to or above reported LC50un-ionized ammonia concentrations. Un-ionized ammonia concentrations in tests with Phos-Chek D75-F were low, thus other toxic components present in the compounds probably contributed to the toxicity. When compared to the daphnids tested in ASTM soft water, the Fire-Trol compounds were most toxic to algae, whereas Phos-Chek D75-F and the foam suppressants were most toxic to daphnids. The results of these tests are comparable to those obtained from research conducted in other laboratories with the same species and similar chemicals. Accidental entry of fire-fighting chemicals into aquatic environments could adversely affect algae and aquatic invertebrates, thus disrupting ecosystem function.

Effects of liquid cooling garments on recovery and performance time in individuals performing strenuous work wearing a firefighter ensemble.

PubMed

Kim, Jung-Hyun; Coca, Aitor; Williams, W Jon; Roberge, Raymond J

2011-07-01

This study investigated the effects of body cooling using liquid cooling garments (LCG) on performance time (PT) and recovery in individuals wearing a fully equipped prototype firefighter ensemble (PFE) incorporating a self-contained breathing apparatus (SCBA). Six healthy male participants (three firefighters and three non-firefighters) completed six experimental sessions in an environmental chamber (35°C, 50% relative humidity), consisting of three stages of 15 min exercise at 75% VO2max, and 10 min rest following each exercise stage. During each session, one of the following six conditions was administered in a randomized order: control (no cooling, CON); air ventilation of exhaust SCBA gases rerouted into the PFE (AV); top cooling garment (TCG); TCG combined with AV (TCG+AV); a shortened whole body cooling garment (SCG), and SCG combined with AV (SCG+AV). Results showed that total PT completed was longer under SCG and SCG+AV compared with CON, AV, TCG, and TCG+AV (p<0.01). Magnitude of core temperature (Tc) elevation was significantly decreased when SCG was utilized (p<0.01), and heart rate recovery rate (10 min) was enhanced under SCG, SCG+AV, TCG, and TCG+AV compared with CON (p<0.05). Estimated Esw rate (kg·h(-1)) was the greatest in CON, 1.62 (0.37), and the least in SCG+AV 0.98 (0.44): (descending order: CON>AV>TCG=TCG+AV>SCG>SCG+AV) without a statistical difference between the conditions (p<0.05). Results of the present study suggest that the application of LCG underneath the PFE significantly improves the recovery during a short period of rest and prolongs performance time in subsequent bouts of exercise. LCG also appears to be an effective method for body cooling that promotes heat dissipation during uncompensable heat stress.

Organizing and Typing Persistent Objects Within an Object-Oriented Framework

NASA Technical Reports Server (NTRS)

Madany, Peter W.; Campbell, Roy H.

1991-01-01

Conventional operating systems provide little or no direct support for the services required for an efficient persistent object system implementation. We have built a persistent object scheme using a customization and extension of an object-oriented operating system called Choices. Choices includes a framework for the storage of persistent data that is suited to the construction of both conventional file system and persistent object system. In this paper we describe three areas in which persistent object support differs from file system support: storage organization, storage management, and typing. Persistent object systems must support various sizes of objects efficiently. Customizable containers, which are themselves persistent objects and can be nested, support a wide range of object sizes in Choices. Collections of persistent objects that are accessed as an aggregate and collections of light-weight persistent objects can be clustered in containers that are nested within containers for larger objects. Automated garbage collection schemes are added to storage management and have a major impact on persistent object applications. The Choices persistent object store provides extensible sets of persistent object types. The store contains not only the data for persistent objects but also the names of the classes to which they belong and the code for the operation of the classes. Besides presenting persistent object storage organization, storage management, and typing, this paper discusses how persistent objects are named and used within the Choices persistent data/file system framework.

Water immersion facility general description, spacecraft design division, crew station branch

NASA Technical Reports Server (NTRS)

1978-01-01

The Water Immersion Facility provides an accurate, safe, neutral buoyancy simulation of zero gravity conditions for development of equipment and procedures, and the training of crews. A detailed description is given of some of the following systems: (1) water tank and support equipment; (2) communications systems; (3) environmental control and liquid cooled garment system (EcS/LCG); (4) closed circuit television system; and (5) medical support system.

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies.

PubMed

Elnaggar, Yosra Sr; Talaat, Sara M; Bahey-El-Din, Mohammed; Abdallah, Ossama Y

Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to poor skin permeation and challenging physicochemical properties, Tr was not employed for the treatment of cutaneous candidiasis. This is the first study to investigate the relevance of novel lecithin-integrated liquid crystalline nano-organogels (LCGs) to improve physicochemical characteristics of Tr in order to enable its dermal application in skin candidiasis. Ternary phase diagram was constructed using lecithin/capryol 90/water to identify the region of liquid crystalline organogel. The selected organogel possessed promising physicochemical characteristics based on particle size, rheological behavior, pH, loading efficiency, and in vitro antifungal activity. Microstructure of the selected organogel was confirmed by polarized light microscopy and transmission electron microscopy. Ex vivo and in vivo skin permeation studies revealed a significant 4.7- and 2.7-fold increase in the permeability of Tr-loaded LCG when compared to conventional hydrogel. Moreover, acute irritation study indicated safety and compatibility of liquid crystalline organogel to the skin. The in vivo antifungal activity confirmed the superiority of LCG over the conventional hydrogel for the eradication of Candida infection. Overall, lecithin-based liquid crystalline organogel confirmed its potential as an interesting dermal nanocarrier for skin targeting purpose.

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies

PubMed Central

Elnaggar, Yosra SR; Talaat, Sara M; Bahey-El-Din, Mohammed; Abdallah, Ossama Y

2016-01-01

Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to poor skin permeation and challenging physicochemical properties, Tr was not employed for the treatment of cutaneous candidiasis. This is the first study to investigate the relevance of novel lecithin-integrated liquid crystalline nano-organogels (LCGs) to improve physicochemical characteristics of Tr in order to enable its dermal application in skin candidiasis. Ternary phase diagram was constructed using lecithin/capryol 90/water to identify the region of liquid crystalline organogel. The selected organogel possessed promising physicochemical characteristics based on particle size, rheological behavior, pH, loading efficiency, and in vitro antifungal activity. Microstructure of the selected organogel was confirmed by polarized light microscopy and transmission electron microscopy. Ex vivo and in vivo skin permeation studies revealed a significant 4.7- and 2.7-fold increase in the permeability of Tr-loaded LCG when compared to conventional hydrogel. Moreover, acute irritation study indicated safety and compatibility of liquid crystalline organogel to the skin. The in vivo antifungal activity confirmed the superiority of LCG over the conventional hydrogel for the eradication of Candida infection. Overall, lecithin-based liquid crystalline organogel confirmed its potential as an interesting dermal nanocarrier for skin targeting purpose. PMID:27822033

Acute toxicity of firefighting chemical formulations to four life stages of fathead minnow

USGS Publications Warehouse

Gaikowski, Mark P.; Hamilton, Steve J.; Buhl, Kevin J.; McDonald, Susan F.; Summers, Cliff H.

1996-01-01

Laboratory studies were conducted with four early life stages of fathead minnow,Pimephales promelas,to determine the acute toxicity of five firefighting chemical formulations in standardized soft and hard water. Egg, fry, 30-day posthatch, and 60-day posthatch life stages were tested with three fire retardants (Fire-Trol GTS-R, Fire-Trol LCG-R, and Phos-Chek D75-F) and two fire-suppressant foams (Phos-Chek WD-881 and Ansul Silv-Ex). Fry were generally the most sensitive life stage tested, whereas the eggs were the least sensitive life stage. Formulation toxicity was greater in hard water than in soft water for all life stages tested. Fire-suppressant foams were more toxic than the fire retardants. The 96-hr LC50s derived for fathead minnows were rank ordered from the most toxic to the least toxic formulation as follows: Phos-Chek WD-881 (13a??32 mg/liter) > Silv-Ex (19a??32 mg/liter) > Fire-Trol GTS-R (135a??787 mg/liter) > Phos-Chek D75-F (168a??2250 mg/liter) > Fire-Trol LCG-R (519a??6705 mg/liter) (ranges are the lowest and highest 96-hr LC50for each formulation). (C) 1996 Academic Press, Inc.

Acute toxicity of fire-retardant and foam-suppressant chemicals to yalella azteca (Saussure)

USGS Publications Warehouse

McDonald, Susan F.; Hamilton, Steven J.; Buhl, Kevin J.; Heisinger, James F.

1997-01-01

Acute toxicity tests were conducted with Hyalella azteca Saussure (an amphipod) exposed in soft and hard waters to three fire retardants (Fire-Trol GTS-R, Fire-Trol LCG-R, and Phos-Chek D75-F) and two foam suppressants (Phos-Chek WD-881 and Silv-Ex). The chemicals were slightly to moderately toxic to amphipods. The most toxic chemical to amphipods in soft and hard water was Phos-Chek WD-881 (96-h mean lethal concentration [LC50] equal to 10 mg/L and 22 mg/L, respectively), and the least toxic chemical to amphipods in soft water was Fire-Trol GTS-R (96-h LC50 equal to 127 mg/L) and in hard water was Fire-Trol LCG-R (96-h LC50 equal to 535 mg/L). Concentrations of ammonia in tests with the three fire retardants and both water types were greater than reported LC50 values and probably were the major toxic component. Estimated un-ionized ammonia concentrations near the LC50 were frequently less than the reported LC50 ammonia concentrations for amphipods. The three fire retardants were more toxic in soft water than in hard water even though ammonia and un-ionized ammonia concentrations were higher in hard water tests than in soft water tests. The accidental entry of fire-fighting chemicals into aquatic environments could adversely affect aquatic invertebrates, thereby disrupting ecosystem function.

Acute toxicity of fire-retardant and foam-suppressant chemicals to early life stages of chinook salmon (Oncorhynchus tshawytscha)

USGS Publications Warehouse

Buhl, Kevin J.; Hamilton, Steven J.

1998-01-01

Laboratorys studies were conducted to determine the acute toxicity of three fire retardants (Fire-Trol GTS-R, Fire-Trol LCG-R, and Phos-Chek D75-F), and two fire-suppressant foams (Phos-Chek WD-881 and Ansul Silv-Ex) to early life stages of chinook salmon, Oncorhynchus tshawytscha, in hard and soft water. Regardless of water type, swim-up fry and juveniles (60 and 90 d posthatch) exhibited similar sensitivities to each chemical and these life stages were more sensitive than eyed eggs. Foam suppressants were more toxic to each life stage than the fire retardants in both water types. The descending rank order of toxicity for these chemicals tested with swim-up fry and juveniles (range of 96-h median lethal concentrations [LC50s]) was Phos-Chek WD-881 (7–13 mg/L) > Ansul Silv-Ex (11–22 mg/L) > Phos-Chek D75-F (218–305 mg/L) > Fire-Trol GTS-R (218–412 mg/L) > Fire-Trol LCG-R (685–1,195 mg/L). Water type had a minor effect on the toxicity of these chemicals. Comparison of acute toxicity values with recommended application concentrations indicates that accidental inputs of these chemicals into stream environments would require substantial dilution (237- to 1,429-fold) to reach concentrations equivalent to their 96-h LC50s.

Post-exercise cooling techniques in hot, humid conditions.

PubMed

Barwood, Martin James; Davey, Sarah; House, James R; Tipton, Michael J

2009-11-01

Major sporting events are often held in hot and humid environmental conditions. Cooling techniques have been used to reduce the risk of heat illness following exercise. This study compared the efficacy of five cooling techniques, hand immersion (HI), whole body fanning (WBF), an air cooled garment (ACG), a liquid cooled garment (LCG) and a phase change garment (PCG), against a natural cooling control condition (CON) over two periods between and following exercise bouts in 31 degrees C, 70%RH air. Nine males [age 22 (3) years; height 1.80 (0.04) m; mass 69.80 (7.10) kg] exercised on a treadmill at a maximal sustainable work intensity until rectal temperature (T (re)) reached 38.5 degrees C following which they underwent a resting recovery (0-15 min; COOL 1). They then recommenced exercise until T (re) again reached 38.5 degrees C and then undertook 30 min of cooling with (0-15 min; COOL 2A), and without face fanning (15-30 min; COOL 2B). Based on mean body temperature changes (COOL 1), WBF was most effective in extracting heat: CON 99 W; WBF: 235 W; PCG: 141 W; HI: 162 W; ACG: 101 W; LCG: 49 W) as a consequence of evaporating more sweat. Therefore, WBF represents a cheap and practical means of post-exercise cooling in hot, humid conditions in a sporting setting.

A fusible heat sink concept for extravehicular activity /EVA/ thermal control

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.

1976-01-01

This paper describes the preliminary design and analysis of a heat sink system, utilizing a phase change slurry material, to be used for astronaut and equipment cooling during manned space missions. During normal use, excess heat in the liquid cooling garment (LCG) coolant is transferred to a regenerable fusible heat sink. Recharge is accomplished by disconnecting the heat sink from the liquid cooling garment and placing it in an onboard freezer for simultaneous slurry refreeze and power supply recharge.

Promoting Student Learning and Productive Persistence in Developmental Mathematics: Research Frameworks Informing the Carnegie Pathways

ERIC Educational Resources Information Center

Edwards, Ann R.; Beattie, Rachel L.

2016-01-01

This paper focuses on two research-based frameworks that inform the design of instruction and promote student success in accelerated, developmental mathematics pathways. These are Learning Opportunities--productive struggle on challenging and relevant tasks, deliberate practice, and explicit connections, and Productive Persistence--promoting…

Using OSG Computing Resources with (iLC)Dirac

NASA Astrophysics Data System (ADS)

Sailer, A.; Petric, M.; CLICdp Collaboration

2017-10-01

CPU cycles for small experiments and projects can be scarce, thus making use of all available resources, whether dedicated or opportunistic, is mandatory. While enabling uniform access to the LCG computing elements (ARC, CREAM), the DIRAC grid interware was not able to use OSG computing elements (GlobusCE, HTCondor-CE) without dedicated support at the grid site through so called ‘SiteDirectors’, which directly submit to the local batch system. This in turn requires additional dedicated effort for small experiments on the grid site. Adding interfaces to the OSG CEs through the respective grid middleware is therefore allowing accessing them within the DIRAC software without additional site-specific infrastructure. This enables greater use of opportunistic resources for experiments and projects without dedicated clusters or an established computing infrastructure with the DIRAC software. To allow sending jobs to HTCondor-CE and legacy Globus computing elements inside DIRAC the required wrapper classes were developed. Not only is the usage of these types of computing elements now completely transparent for all DIRAC instances, which makes DIRAC a flexible solution for OSG based virtual organisations, but it also allows LCG Grid Sites to move to the HTCondor-CE software, without shutting DIRAC based VOs out of their site. In these proceedings we detail how we interfaced the DIRAC system to the HTCondor-CE and Globus computing elements and explain the encountered obstacles and solutions developed, and how the linear collider community uses resources in the OSG.

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

PubMed Central

Linaro, Daniele; Couto, João; Giugliano, Michele

2015-01-01

Experimental neuroscience is witnessing an increased interest in the development and application of novel and often complex, closed-loop protocols, where the stimulus applied depends in real-time on the response of the system. Recent applications range from the implementation of virtual reality systems for studying motor responses both in mice1 and in zebrafish2, to control of seizures following cortical stroke using optogenetics3. A key advantage of closed-loop techniques resides in the capability of probing higher dimensional properties that are not directly accessible or that depend on multiple variables, such as neuronal excitability4 and reliability, while at the same time maximizing the experimental throughput. In this contribution and in the context of cellular electrophysiology, we describe how to apply a variety of closed-loop protocols to the study of the response properties of pyramidal cortical neurons, recorded intracellularly with the patch clamp technique in acute brain slices from the somatosensory cortex of juvenile rats. As no commercially available or open source software provides all the features required for efficiently performing the experiments described here, a new software toolbox called LCG5 was developed, whose modular structure maximizes reuse of computer code and facilitates the implementation of novel experimental paradigms. Stimulation waveforms are specified using a compact meta-description and full experimental protocols are described in text-based configuration files. Additionally, LCG has a command-line interface that is suited for repetition of trials and automation of experimental protocols. PMID:26132434

Thermal Performance Testing of EMU and OSS Liquid Cooling Garments

NASA Technical Reports Server (NTRS)

Rhodes, Richard; Bue, Grant; Hakam, Mary

2012-01-01

A test was conducted to evaluate three factors influencing the thermal performance of liquid cooling garments (LCG): (1) the comparable thermal performance of an Oceaneering developed engineering evaluation unit (EEU) prototype LDG, (2) the effect of the thermal comfort undergarment (TCU), and (3) the performance of a torso or upper body only LCG configuration. To evaluate the thermal performance of each configuration a metabolic test was conducted, utilizing suited subjects to generate the metabolic heat. For this study three (3) test subjects of similar health and weight produced a metabolic load on the LDG configuration by either resting (300-600 BTU/hr), walking at a slow pace (1200 BRU/hr), and walking at a brisk pace (2200 BTU/hr), as outlined in Figure 1, the metabolic profile. During the test, oxygen consumption, heart rate, relative humidity, air flow, inlet and outlet air pressure, inlet and outlet air temperature, delta air temperature, water flow (100 lb/hr), inlet water temperature (64 F), delta water temperature, water pressure, core body temperature, skin temperature, and sweat loss data was recorded. Four different test configurations were tested, with one configuration tested twice, as outlined in Table 1. The test was conducted with the suit subjects wearing the Demonstrator Suit, pressurized to vent pressure (approximately 0.5 psig). The demonstrator suit has an integrated ventilation duct system and was used to create a relevant environment with a captured ventilation return, an integrated vent tree, and thermal insulation from the environment.

Metrics for comparing neuronal tree shapes based on persistent homology.

PubMed

Li, Yanjie; Wang, Dingkang; Ascoli, Giorgio A; Mitra, Partha; Wang, Yusu

2017-01-01

As more and more neuroanatomical data are made available through efforts such as NeuroMorpho.Org and FlyCircuit.org, the need to develop computational tools to facilitate automatic knowledge discovery from such large datasets becomes more urgent. One fundamental question is how best to compare neuron structures, for instance to organize and classify large collection of neurons. We aim to develop a flexible yet powerful framework to support comparison and classification of large collection of neuron structures efficiently. Specifically we propose to use a topological persistence-based feature vectorization framework. Existing methods to vectorize a neuron (i.e, convert a neuron to a feature vector so as to support efficient comparison and/or searching) typically rely on statistics or summaries of morphometric information, such as the average or maximum local torque angle or partition asymmetry. These simple summaries have limited power in encoding global tree structures. Based on the concept of topological persistence recently developed in the field of computational topology, we vectorize each neuron structure into a simple yet informative summary. In particular, each type of information of interest can be represented as a descriptor function defined on the neuron tree, which is then mapped to a simple persistence-signature. Our framework can encode both local and global tree structure, as well as other information of interest (electrophysiological or dynamical measures), by considering multiple descriptor functions on the neuron. The resulting persistence-based signature is potentially more informative than simple statistical summaries (such as average/mean/max) of morphometric quantities-Indeed, we show that using a certain descriptor function will give a persistence-based signature containing strictly more information than the classical Sholl analysis. At the same time, our framework retains the efficiency associated with treating neurons as points in a simple Euclidean feature space, which would be important for constructing efficient searching or indexing structures over them. We present preliminary experimental results to demonstrate the effectiveness of our persistence-based neuronal feature vectorization framework.

Metrics for comparing neuronal tree shapes based on persistent homology

PubMed Central

Li, Yanjie; Wang, Dingkang; Ascoli, Giorgio A.; Mitra, Partha

2017-01-01

As more and more neuroanatomical data are made available through efforts such as NeuroMorpho.Org and FlyCircuit.org, the need to develop computational tools to facilitate automatic knowledge discovery from such large datasets becomes more urgent. One fundamental question is how best to compare neuron structures, for instance to organize and classify large collection of neurons. We aim to develop a flexible yet powerful framework to support comparison and classification of large collection of neuron structures efficiently. Specifically we propose to use a topological persistence-based feature vectorization framework. Existing methods to vectorize a neuron (i.e, convert a neuron to a feature vector so as to support efficient comparison and/or searching) typically rely on statistics or summaries of morphometric information, such as the average or maximum local torque angle or partition asymmetry. These simple summaries have limited power in encoding global tree structures. Based on the concept of topological persistence recently developed in the field of computational topology, we vectorize each neuron structure into a simple yet informative summary. In particular, each type of information of interest can be represented as a descriptor function defined on the neuron tree, which is then mapped to a simple persistence-signature. Our framework can encode both local and global tree structure, as well as other information of interest (electrophysiological or dynamical measures), by considering multiple descriptor functions on the neuron. The resulting persistence-based signature is potentially more informative than simple statistical summaries (such as average/mean/max) of morphometric quantities—Indeed, we show that using a certain descriptor function will give a persistence-based signature containing strictly more information than the classical Sholl analysis. At the same time, our framework retains the efficiency associated with treating neurons as points in a simple Euclidean feature space, which would be important for constructing efficient searching or indexing structures over them. We present preliminary experimental results to demonstrate the effectiveness of our persistence-based neuronal feature vectorization framework. PMID:28809960

Developing the Mid-Level Civilian Logistician: An Empirical Study of United States Air Force GS-12 to GM-13 Professional Development.

DTIC Science & Technology

1989-09-01

airimn : PME NUMBER OF APPLICABLE RESPONSES PROGRAMS S S~ 1quadron Off icer-S SchoolI. Ai~rCcr 1 .n College, Air War College: self-direct-d Table 11...8217 betweenr- thie number of e:;ist ~p ~msancre:.t7 lcg~stiian weak-nesses (r -. 8545 ) Inditc. r: lo:w pcoitlive correlation e:xists b_-etween thenubr...equivalent) c. Industrial College of the Armed Forces d. Defense Systems Management Course e. Air War College (or equivalent) f. Other (please specify) g

Women's experiences of hormonal therapy for breast cancer: exploring influences on medication-taking behaviour.

PubMed

Cahir, Caitriona; Dombrowski, Stephan U; Kelly, Catherine M; Kennedy, M John; Bennett, Kathleen; Sharp, Linda

2015-11-01

Five to 10 years of adjuvant hormonal therapy is recommended to prevent breast cancer recurrence. This study investigated modifiable influences on adjuvant hormonal therapy medication-taking behaviour (MTB) in women with stage I-III breast cancer. Semi-structured face-to-face interviews among women with stage I-III breast cancer prescribed adjuvant hormonal therapy purposively sampled by their MTB at two cancer centres. Thematic analysis was conducted based on the Framework approach, with the Theoretical Domains Framework (TDF) informing the analysis framework; the TDF is an integrative framework consisting of 14 domains of behavioural change to inform intervention design. Thirty-one women participated in interviews (14 adherent/persistent; 7 non-adherent/persistent; 10 non-persistent). Three domains identified both barriers and enablers to hormonal therapy MTB across the three MTB strata: beliefs about consequences, intentions and goals and behaviour regulation, but their influence was different across the strata. Other domains influenced individual MTB strata. Key enablers for adherent/persistent women were identified within the domain beliefs about consequences (breast cancer recurrence), intentions and goals (high-priority), beliefs about capabilities (side effects) and behaviour regulation (managing medication). Barriers were identified within the domain behaviour regulation (no routine), memory, attention and decision processes (forgetting) and environmental context and resources (stressors) for non-adherent/persistent women and intentions and goals (quality of life), behaviour regulation (temporal self-regulation), reinforcement, beliefs about consequences (non-necessity) and social influences (clinical support) for non-persistent women. This study identified modifiable influences on hormonal therapy MTB. Targeting these influences in clinical practice may improve MTB and hence survival in this population.

Eurogrid: a new glideinWMS based portal for CDF data analysis

NASA Astrophysics Data System (ADS)

Amerio, S.; Benjamin, D.; Dost, J.; Compostella, G.; Lucchesi, D.; Sfiligoi, I.

2012-12-01

The CDF experiment at Fermilab ended its Run-II phase on September 2011 after 11 years of operations and 10 fb-1 of collected data. CDF computing model is based on a Central Analysis Farm (CAF) consisting of local computing and storage resources, supported by OSG and LCG resources accessed through dedicated portals. At the beginning of 2011 a new portal, Eurogrid, has been developed to effectively exploit computing and disk resources in Europe: a dedicated farm and storage area at the TIER-1 CNAF computing center in Italy, and additional LCG computing resources at different TIER-2 sites in Italy, Spain, Germany and France, are accessed through a common interface. The goal of this project is to develop a portal easy to integrate in the existing CDF computing model, completely transparent to the user and requiring a minimum amount of maintenance support by the CDF collaboration. In this paper we will review the implementation of this new portal, and its performance in the first months of usage. Eurogrid is based on the glideinWMS software, a glidein based Workload Management System (WMS) that works on top of Condor. As CDF CAF is based on Condor, the choice of the glideinWMS software was natural and the implementation seamless. Thanks to the pilot jobs, user-specific requirements and site resources are matched in a very efficient way, completely transparent to the users. Official since June 2011, Eurogrid effectively complements and supports CDF computing resources offering an optimal solution for the future in terms of required manpower for administration, support and development.

Persistent model order reduction for complex dynamical systems using smooth orthogonal decomposition

NASA Astrophysics Data System (ADS)

Ilbeigi, Shahab; Chelidze, David

2017-11-01

Full-scale complex dynamic models are not effective for parametric studies due to the inherent constraints on available computational power and storage resources. A persistent reduced order model (ROM) that is robust, stable, and provides high-fidelity simulations for a relatively wide range of parameters and operating conditions can provide a solution to this problem. The fidelity of a new framework for persistent model order reduction of large and complex dynamical systems is investigated. The framework is validated using several numerical examples including a large linear system and two complex nonlinear systems with material and geometrical nonlinearities. While the framework is used for identifying the robust subspaces obtained from both proper and smooth orthogonal decompositions (POD and SOD, respectively), the results show that SOD outperforms POD in terms of stability, accuracy, and robustness.

Supporting Academic Persistence in Low-Skilled Adult Learners

ERIC Educational Resources Information Center

O'Neill, Susan; Thomson, Margareta Maria

2013-01-01

The current literature review explores the factors that contribute to academic persistence for adult learners. The aim of the study is to identify current research-based strategies aimed at supporting learner persistence, particularly for low-skilled adults. Elements of three theoretical frameworks, namely, expectancy-value theory (EVT), goal…

Fundamental bound on the persistence and capacity of short-term memory stored as graded persistent activity.

PubMed

Koyluoglu, Onur Ozan; Pertzov, Yoni; Manohar, Sanjay; Husain, Masud; Fiete, Ila R

2017-09-07

It is widely believed that persistent neural activity underlies short-term memory. Yet, as we show, the degradation of information stored directly in such networks behaves differently from human short-term memory performance. We build a more general framework where memory is viewed as a problem of passing information through noisy channels whose degradation characteristics resemble those of persistent activity networks. If the brain first encoded the information appropriately before passing the information into such networks, the information can be stored substantially more faithfully. Within this framework, we derive a fundamental lower-bound on recall precision, which declines with storage duration and number of stored items. We show that human performance, though inconsistent with models involving direct (uncoded) storage in persistent activity networks, can be well-fit by the theoretical bound. This finding is consistent with the view that if the brain stores information in patterns of persistent activity, it might use codes that minimize the effects of noise, motivating the search for such codes in the brain.

Fundamental bound on the persistence and capacity of short-term memory stored as graded persistent activity

PubMed Central

Pertzov, Yoni; Manohar, Sanjay; Husain, Masud; Fiete, Ila R

2017-01-01

It is widely believed that persistent neural activity underlies short-term memory. Yet, as we show, the degradation of information stored directly in such networks behaves differently from human short-term memory performance. We build a more general framework where memory is viewed as a problem of passing information through noisy channels whose degradation characteristics resemble those of persistent activity networks. If the brain first encoded the information appropriately before passing the information into such networks, the information can be stored substantially more faithfully. Within this framework, we derive a fundamental lower-bound on recall precision, which declines with storage duration and number of stored items. We show that human performance, though inconsistent with models involving direct (uncoded) storage in persistent activity networks, can be well-fit by the theoretical bound. This finding is consistent with the view that if the brain stores information in patterns of persistent activity, it might use codes that minimize the effects of noise, motivating the search for such codes in the brain. PMID:28879851

Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women.

PubMed

da Silva Ferreira, Thaís; Torres, Márcia Regina Simas Gonçalves; Sanjuliani, Antonio Felipe

2013-09-28

Recent studies have suggested that dietary Ca may have beneficial effects on adiposity, insulin resistance, dyslipidaemia and blood pressure (BP). One potential mechanism underlying these benefits involves modifications in intracellular Ca concentration ([Ca2+]i). The present study aimed to evaluate the associations of dietary Ca with adiposity, erythrocyte [Ca2+]i, metabolic profile, BP, inflammatory state and endothelial function in healthy pre-menopausal women. In the present cross-sectional study, seventy-six women aged 18–50 years were submitted to the evaluation of dietary intake, anthropometric parameters, body composition, erythrocyte [Ca2+]i, biochemical variables, endothelial function and BP. A FFQ was used to assess usual dietary intake. Endothelial function was evaluated by serum concentrations of adhesion molecules and by the peripheral arterial tonometry (PAT) method, using Endo-PAT 2000®. Participants were allocated into two groups according to Ca intake: low-Ca group (LCG; n 32; < 600 mg/d) and high-Ca group (HCG; n 44; ≥ 600 mg/d). Women in the LCG compared with those in the HCG exhibited, after adjustments for potential confounders, higher values of BMI, waist circumference, waist:height ratio, percentage of body fat, insulin, homeostasis model assessment of insulin resistance, leptin, diastolic and mean BP; and lower levels of HDL-cholesterol, adiponectin and vascular cell adhesion molecule 1. Endothelial function assessed by PAT and [Ca2+]i was similar in both groups. Subjects in the HCG had lower OR for prevalent overweight, obesity, abdominal obesity, insulin resistance, HDL-cholesterol < 600 mg/l and systolic BP >120 mmHg. The findings of the present study suggest that high Ca intake is inversely associated with some cardiovascular risk factors.

Comparative genomics of Lactobacillus

PubMed Central

Kant, Ravi; Blom, Jochen; Palva, Airi; Siezen, Roland J.; de Vos, Willem M.

2011-01-01

Summary The genus Lactobacillus includes a diverse group of bacteria consisting of many species that are associated with fermentations of plants, meat or milk. In addition, various lactobacilli are natural inhabitants of the intestinal tract of humans and other animals. Finally, several Lactobacillus strains are marketed as probiotics as their consumption can confer a health benefit to host. Presently, 154 Lactobacillus species are known and a growing fraction of these are subject to draft genome sequencing. However, complete genome sequences are needed to provide a platform for detailed genomic comparisons. Therefore, we selected a total of 20 genomes of various Lactobacillus strains for which complete genomic sequences have been reported. These genomes had sizes varying from 1.8 to 3.3 Mb and other characteristic features, such as G+C content that ranged from 33% to 51%. The Lactobacillus pan genome was found to consist of approximately 14 000 protein‐encoding genes while all 20 genomes shared a total of 383 sets of orthologous genes that defined the Lactobacillus core genome (LCG). Based on advanced phylogeny of the proteins encoded by this LCG, we grouped the 20 strains into three main groups and defined core group genes present in all genomes of a single group, signature group genes shared in all genomes of one group but absent in all other Lactobacillus genomes, and Group‐specific ORFans present in core group genes of one group and absent in all other complete genomes. The latter are of specific value in defining the different groups of genomes. The study provides a platform for present individual comparisons as well as future analysis of new Lactobacillus genomes. PMID:21375712

Technical Evaluation of the Norwegian Crew Concept Boat (CG-502001) and Comparison to the 41-FT Utility Boat (UTB)

DTIC Science & Technology

1993-11-01

6.36 5.94 6.39 5.99 GMo (ft) 5.07 4.68 4.83 4.60 FSM (ft-lbs) .00 1232.00 1232.00 1232.00 FSC (ft) .00 .02 .02 .02 GMt (ft) 5.07 4.66 4.81 4.58 LCG (ft...mechanical plant , the 502001 can certainly get underway for an emergency response in less than ten minutes of notification, assuming that all crew members are...of the well deck and the stern ramp permit the crew to deploy pollution control booms from the boat. The stern ramp is also useful as a platform and

All New and All Outcome-Based? The German Qualifications Framework and the Persistence of National Governance Approaches

ERIC Educational Resources Information Center

Gössling, Bernd

2016-01-01

This article analyses the development of the first national qualifications framework in Germany ("Deutscher Qualifikationsrahmen" or "DQR"). In this case, a qualifications framework, which is supposedly outcome-based, had to be adapted to a highly input-oriented qualification system. This raises the question, how clashing…

Rapid development of entity-based data models for bioinformatics with persistence object-oriented design and structured interfaces.

PubMed

Ezra Tsur, Elishai

2017-01-01

Databases are imperative for research in bioinformatics and computational biology. Current challenges in database design include data heterogeneity and context-dependent interconnections between data entities. These challenges drove the development of unified data interfaces and specialized databases. The curation of specialized databases is an ever-growing challenge due to the introduction of new data sources and the emergence of new relational connections between established datasets. Here, an open-source framework for the curation of specialized databases is proposed. The framework supports user-designed models of data encapsulation, objects persistency and structured interfaces to local and external data sources such as MalaCards, Biomodels and the National Centre for Biotechnology Information (NCBI) databases. The proposed framework was implemented using Java as the development environment, EclipseLink as the data persistency agent and Apache Derby as the database manager. Syntactic analysis was based on J3D, jsoup, Apache Commons and w3c.dom open libraries. Finally, a construction of a specialized database for aneurysms associated vascular diseases is demonstrated. This database contains 3-dimensional geometries of aneurysms, patient's clinical information, articles, biological models, related diseases and our recently published model of aneurysms' risk of rapture. Framework is available in: http://nbel-lab.com.

DEVELOPING AN INTERNATIONAL CONSENSUS ON DDT: A BALANCE OF ENVIRONMENTAL PROTECTION AND DISEASE CONTROL.

EPA Science Inventory

The Stockholm Convention on Persistent Organic Pollutants provides a framework for international action on 12 persistent, bioaccumulative and toxic chemicals of global concern. While production and use of most of the listed chemicals will shortly be eliminated, there is widespre...

Random number generators tested on quantum Monte Carlo simulations.

PubMed

Hongo, Kenta; Maezono, Ryo; Miura, Kenichi

2010-08-01

We have tested and compared several (pseudo) random number generators (RNGs) applied to a practical application, ground state energy calculations of molecules using variational and diffusion Monte Carlo metheds. A new multiple recursive generator with 8th-order recursion (MRG8) and the Mersenne twister generator (MT19937) are tested and compared with the RANLUX generator with five luxury levels (RANLUX-[0-4]). Both MRG8 and MT19937 are proven to give the same total energy as that evaluated with RANLUX-4 (highest luxury level) within the statistical error bars with less computational cost to generate the sequence. We also tested the notorious implementation of linear congruential generator (LCG), RANDU, for comparison. (c) 2010 Wiley Periodicals, Inc.

The drinking water disparities framework: on the origins and persistence of inequities in exposure.

PubMed

Balazs, Carolina L; Ray, Isha

2014-04-01

With this article, we develop the Drinking Water Disparities Framework to explain environmental injustice in the context of drinking water in the United States. The framework builds on the social epidemiology and environmental justice literatures, and is populated with 5 years of field data (2005-2010) from California's San Joaquin Valley. We trace the mechanisms through which natural, built, and sociopolitical factors work through state, county, community, and household actors to constrain access to safe water and to financial resources for communities. These constraints and regulatory failures produce social disparities in exposure to drinking water contaminants. Water system and household coping capacities lead, at best, to partial protection against exposure. This composite burden explains the origins and persistence of social disparities in exposure to drinking water contaminants.

Implementation of data node in spatial information grid based on WS resource framework and WS notification

NASA Astrophysics Data System (ADS)

Zhang, Dengrong; Yu, Le

2006-10-01

Abstract-An approach of constructing a data node in spatial information grid (SIG) based on Web Service Resource Framework (WSRF) and Web Service Notification (WSN) is described in this paper. Attentions are paid to construct and implement SIG's resource layer, which is the most important part. A study on this layer find out, it is impossible to require persistent interaction with the clients of the services in common SIG architecture because of inheriting "stateless" and "not persistent" limitations of Web Service. A WSRF/WSN-based data node is designed to hurdle this short comes. Three different access modes are employed to test the availability of this node. Experimental results demonstrate this service node can successfully respond to standard OGC requests and returns specific spatial data in different network environment, also is stateful, dynamic and persistent.

Exploring Faculty Members' Motivation and Persistence in Academic Service-Learning Pedagogy

ERIC Educational Resources Information Center

Darby, Alexa; Newman, Gabrielle

2014-01-01

This qualitative study provides a theoretical framework for understanding faculty members' motivation to persist in utilizing academic service-learning pedagogy. Twenty-four faculty members from a private liberal arts university in the southeastern United States were interviewed about the benefits and challenges of teaching academic…

Persistent Places and Paths on the Middle Western Plain.

ERIC Educational Resources Information Center

Borchert, John R.

1986-01-01

Briefly sketches the origin and persistence of the Midwest as a physical, city-centered circulation and settlement system drawing from physical, cultural, economic, and applied specialties within geography. Illustrates the coherence of the specialties within a regional-historical framework with basic geographic/scientific problems of scale,…

Cooling Properties of the Shuttle Advanced Crew Escape Spacesuit: Results of an Environmental Chamber Experiment

NASA Technical Reports Server (NTRS)

Hamilton, Douglas; Gillis, David; Bue, Grant; Son, Chan; Norcross, Jason; Kuznetz, Larry; Chapman, Kirt; Chhipwadia, Ketan; McBride, Tim

2008-01-01

The shuttle crew wears the Advanced Crew Escape Spacesuit (ACES) to protect themselves from cabin decompression and to support bail out during landing. ACES is cooled by a liquid-cooled garment (LCG) that interfaces to a heat exchanger that dumps heat into the cabin. The ACES outer layer is made of Gore-Tex(Registered TradeMark), permitting water vapor to escape while containing oxygen. The crew can only lose heat via insensible water losses and the LCG. Under nominal landing operations, the average cabin temperature rarely exceeds 75 F, which is adequate for the ACES to function. Problem A rescue shuttle will need to return 11 crew members if the previous mission suffers a thermal protection system failure, preventing it from returning safely to Earth. Initial analysis revealed that 11 crew members in the shuttle will increase cabin temperature at wheel stop above 80 F, which decreases the ACES ability to keep crew members cool. Air flow in the middeck of the shuttle is inhomogeneous and some ACES may experience much higher temperatures that could cause excessive thermal stress to crew members. Methods A ground study was conducted to measure the cooling efficiency of the ACES at 75 F, 85 F, and 95 F at 50% relative humidity. Test subjects representing 5, 50, and 95 percentile body habitus of the astronaut corps performed hand ergometry keeping their metabolic rate at 400, 600, and 800 BTU/hr for one hour. Core temperature was measured by rectal probe and skin, while inside and outside the suit. Environmental chamber wall and cooling unit inlet and outlet temperatures were measured using high-resolution thermistors ( 0.2 C). Conclusions Under these test conditions, the ACES was able to protect the core temperature of all test subjects, however thermal stress due to high insensible losses and skin temperature and skin heat flow may impact crew performance. Further research should be performed to understand the impact on cognitive performance.

DTI measures identify mild and moderate TBI cases among patients with complex health problems: A receiver operating characteristic analysis of U.S. veterans.

PubMed

Main, Keith L; Soman, Salil; Pestilli, Franco; Furst, Ansgar; Noda, Art; Hernandez, Beatriz; Kong, Jennifer; Cheng, Jauhtai; Fairchild, Jennifer K; Taylor, Joy; Yesavage, Jerome; Wesson Ashford, J; Kraemer, Helena; Adamson, Maheen M

2017-01-01

Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts are most pertinent to TBI diagnosis. This study ranked fiber tracts on their ability to discriminate patients with and without TBI. We acquired diffusion tensor imaging data from military veterans admitted to a polytrauma clinic (Overall n  = 109; Age: M  = 47.2, SD  = 11.3; Male: 88%; TBI: 67%). TBI diagnosis was based on self-report and neurological examination. Fiber tractography analysis produced 20 fiber tracts per patient. Each tract yielded four clinically relevant measures (fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity). We applied receiver operating characteristic (ROC) analyses to identify the most diagnostic tract for each measure. The analyses produced an optimal cutpoint for each tract. We then used kappa coefficients to rate the agreement of each cutpoint with the neurologist's diagnosis. The tract with the highest kappa was most diagnostic. As a check on the ROC results, we performed a stepwise logistic regression on each measure using all 20 tracts as predictors. We also bootstrapped the ROC analyses to compute the 95% confidence intervals for sensitivity, specificity, and the highest kappa coefficients. The ROC analyses identified two fiber tracts as most diagnostic of TBI: the left cingulum (LCG) and the left inferior fronto-occipital fasciculus (LIF). Like ROC, logistic regression identified LCG as most predictive for the FA measure but identified the right anterior thalamic tract (RAT) for the MD, RD, and AD measures. These findings are potentially relevant to the development of TBI biomarkers. Our methods also demonstrate how ROC analysis may be used to identify clinically relevant variables in the TBI population.

The Drinking Water Disparities Framework: On the Origins and Persistence of Inequities in Exposure

PubMed Central

Balazs, Carolina L.; Ray, Isha

2014-01-01

With this article, we develop the Drinking Water Disparities Framework to explain environmental injustice in the context of drinking water in the United States. The framework builds on the social epidemiology and environmental justice literatures, and is populated with 5 years of field data (2005–2010) from California’s San Joaquin Valley. We trace the mechanisms through which natural, built, and sociopolitical factors work through state, county, community, and household actors to constrain access to safe water and to financial resources for communities. These constraints and regulatory failures produce social disparities in exposure to drinking water contaminants. Water system and household coping capacities lead, at best, to partial protection against exposure. This composite burden explains the origins and persistence of social disparities in exposure to drinking water contaminants. PMID:24524500

The Lived Experience of Teachers and Administrators in Persistently Low Achieving Schools

ERIC Educational Resources Information Center

Bickenheuser, Charles William

2013-01-01

In 2010 Washington State's persistently lowest performing public schools were identified and published by the superintendent of public instruction. However, no research has described the lived experiences of teachers and administrators who work in those schools. Guided by the combined frameworks of Van Manen and Moustakas, this qualitative study…

Examining a Grade-Level Math CBM Designed for Persistently Low-Performing Students

ERIC Educational Resources Information Center

Anderson, Daniel; Lai, Cheng-Fei; Alonzo, Julie; Tindal, Gerald

2011-01-01

Students with disabilities participate in two major measurement systems. The Individuals with Disabilities Education Act emphasizes working within a Response to Intervention (RTI) framework to identify and monitor the progress of low-performing students. Persistent low-performing students also may be eligible for some form of an alternate…

Significant Others in the Lives of Latino First-Generation College Students: How Social Capital Aids Persistence

ERIC Educational Resources Information Center

Beard, Trista

2016-01-01

This study examines how successful Latino first-generation college students (LFGCS), all seniors at a large, highly-selective research university, integrated into chosen communities and built unique social networks to support their persistence in college. Utilizing integration and social capital frameworks, and analyzing the college life histories…

Success Factors Impacting Latina/o Persistence in Higher Education Leading to STEM Opportunities

ERIC Educational Resources Information Center

Peralta, Claudia; Caspary, Melissa; Boothe, Diane

2013-01-01

This study investigates how Latina/Latino youth resist, conform to, and persist in schooling, and explores their preparation for an education in science, technology, engineering and math (STEM) fields. Using Latino Critical Race Theory as a framework, evidence of the "sticky mess" of racial inequalities (Espinoza and Harris in"…

Provisional Admission in Higher Education: A Case Study in Retention, Persistence, and Matriculation in Academia

ERIC Educational Resources Information Center

Logan, Monique L.

2017-01-01

The study employed the Clark and Estes (2008) gap analysis framework to investigate the knowledge and skills, motivation, and organizational elements that influence the retention, persistence, and matriculation of provisionally admitted students identified as Scholastic Achievers at United University (UU). Assumed causes of the knowledge,…

The Effects of Generational Status and University Environment on Latina/o Undergraduates' Persistence Decisions

ERIC Educational Resources Information Center

Aguinaga, Arellys; Gloria, Alberta M.

2015-01-01

This study examined the importance of identity and cultural fit within the university on Latina/o undergraduates' academic persistence decisions. The psychosociocultural model (Gloria & Rodriguez, 2000) provided a framework for the study in which 128 Latino/a students' generational level in the United States, cultural congruity, perceptions of…

An Examination of First-to Second-Year Persistence of First-Generation College Students

ERIC Educational Resources Information Center

Guyer, Kimberly Denise

2013-01-01

This dissertation uses a mixed-methods design to examine persistence into the second year by students' parental education level. The institution selected for this dissertation is Temple University, a large, urban, public university in the Northeast. Using Tinto's (1993) model of student departure as a conceptual framework, the quantitative…

Financial Aid and College Persistence: Do Student Loans Help or Hurt?

ERIC Educational Resources Information Center

Herzog, Serge

2018-01-01

Using data from two freshmen cohorts at a public research university (N = 3730), this study examines the relationship between loan aid and second-year enrollment persistence. Applying a counterfactual analytical framework that relies on propensity score (PS) weighting and matching to address selection bias associated with treatment status, the…

MICE data handling on the Grid

NASA Astrophysics Data System (ADS)

Martyniak, J.; Mice Collaboration

2014-06-01

The international Muon Ionisation Cooling Experiment (MICE) is designed to demonstrate the principle of muon ionisation cooling for the first time, for application to a future Neutrino factory or Muon Collider. The experiment is currently under construction at the ISIS synchrotron at the Rutherford Appleton Laboratory (RAL), UK. In this paper we present a system - the Raw Data Mover, which allows us to store and distribute MICE raw data - and a framework for offline reconstruction and data management. The aim of the Raw Data Mover is to upload raw data files onto a safe tape storage as soon as the data have been written out by the DAQ system and marked as ready to be uploaded. Internal integrity of the files is verified and they are uploaded to the RAL Tier-1 Castor Storage Element (SE) and placed on two tapes for redundancy. We also make another copy at a separate disk-based SE at this stage to make it easier for users to access data quickly. Both copies are check-summed and the replicas are registered with an instance of the LCG File Catalog (LFC). On success a record with basic file properties is added to the MICE Metadata DB. The reconstruction process is triggered by new raw data records filled in by the mover system described above. Off-line reconstruction jobs for new raw files are submitted to RAL Tier-1 and the output is stored on tape. Batch reprocessing is done at multiple MICE enabled Grid sites and output files are shipped to central tape or disk storage at RAL using a custom File Transfer Controller.

Creating a Framework of Guidance for Building Good Digital Collections.

ERIC Educational Resources Information Center

Cole, Timothy W.

2002-01-01

Presents the Framework of Guidance for Building Good Digital Collections that was developed by the Institute of Museum and Library Services with other organizations to guide museums and libraries in digitization collection practices. Highlights digital collections, digital objects, and metadata, and discusses reusability, persistence,…

Norms on the gender perception of role nouns in Czech, English, French, German, Italian, Norwegian, and Slovak.

PubMed

Misersky, Julia; Gygax, Pascal M; Canal, Paolo; Gabriel, Ute; Garnham, Alan; Braun, Friederike; Chiarini, Tania; Englund, Kjellrun; Hanulikova, Adriana; Ottl, Anton; Valdrova, Jana; Von Stockhausen, Lisa; Sczesny, Sabine

2014-09-01

We collected norms on the gender stereotypicality of an extensive list of role nouns in Czech, English, French, German, Italian, Norwegian, and Slovak, to be used as a basis for the selection of stimulus materials in future studies. We present a Web-based tool (available at https://www.unifr.ch/lcg/ ) that we developed to collect these norms and that we expect to be useful for other researchers, as well. In essence, we provide (a) gender stereotypicality norms across a number of languages and (b) a tool to facilitate cross-language as well as cross-cultural comparisons when researchers are interested in the investigation of the impact of stereotypicality on the processing of role nouns.

A Comparison of One Time Pad Random Key Generation using Linear Congruential Generator and Quadratic Congruential Generator

NASA Astrophysics Data System (ADS)

Apdilah, D.; Harahap, M. K.; Khairina, N.; Husein, A. M.; Harahap, M.

2018-04-01

One Time Pad algorithm always requires a pairing of the key for plaintext. If the length of keys less than a length of the plaintext, the key will be repeated until the length of the plaintext same with the length of the key. In this research, we use Linear Congruential Generator and Quadratic Congruential Generator for generating a random number. One Time Pad use a random number as a key for encryption and decryption process. Key will generate the first letter from the plaintext, we compare these two algorithms in terms of time speed encryption, and the result is a combination of OTP with LCG faster than the combination of OTP with QCG.

Case Study Analysis of the Effect of Contextual Supports and Barriers on African American Students' Persistence in Engineering

ERIC Educational Resources Information Center

Montgomery, Lisa

2009-01-01

Using case study methodology (Stake, 2006), this research examined the environmental influences, or contextual supports and barriers, that were most influential in contributing to African American students' persistence in an engineering major. Social cognitive career theory provides the framework for understanding the role of contextual supports…

Balancing Act: A Phenomenological Study of Female Adult Learners Who Successfully Persisted in Graduate Studies

ERIC Educational Resources Information Center

Shepherd, Jeff; Nelson, Barbara Mullins

2012-01-01

A study was conducted utilizing Cross' (1981) barriers to adult learning as a framework to better understand how adults successfully complete their graduate studies. Participants in the study were solicited via Facebook and LinkedIn. Three female adult learners who persisted in their graduate studies while balancing demands outside academics…

The Impact of Curricular Learning Communities on Furthering the Engagement and Persistence of Academically Underprepared Students at Community Colleges

ERIC Educational Resources Information Center

McIntosh, Joshua Grant

2012-01-01

This study examined the impact of basic skills curricular learning communities on academically underprepared community college students to determine if participation in such programs significantly contributed to student persistence from year one to year two. The conceptual framework that informed this study was Tinto's (1993) longitudinal model of…

Advance to and Persistence in Graduate School: Identifying the Influential Factors and Major-Based Differences

ERIC Educational Resources Information Center

Xu, Yonghong Jade

2014-01-01

Structured within an expanded econometric theoretical framework, this study uses national data sources to identify the critical factors that influence college graduates' advance to and persistence in graduate education and to compare the systematic differences between students in the STEM and non-STEM majors. The findings indicate that there is a…

Supporting Conditionally-Admitted Students: A Case Study of Assessing Persistence in a Learning Community

ERIC Educational Resources Information Center

Heaney, April; Fisher, Rick

2011-01-01

Using Astin's I-E-O model as a framework, this article explores the effects of a variety of factors on first-year persistence for conditionally-admitted students participating in a learning community at a public land-grant university. Since the learning community began in 2002, program administrators have collected survey, interview, and academic…

Development of risk reduction behavioral counseling for Ebola virus disease survivors enrolled in the Sierra Leone Ebola Virus Persistence Study, 2015-2016.

PubMed

Abad, Neetu; Malik, Tasneem; Ariyarajah, Archchun; Ongpin, Patricia; Hogben, Matthew; McDonald, Suzanna L R; Marrinan, Jaclyn; Massaquoi, Thomas; Thorson, Anna; Ervin, Elizabeth; Bernstein, Kyle; Ross, Christine; Liu, William J; Kroeger, Karen; Durski, Kara N; Broutet, Nathalie; Knust, Barbara; Deen, Gibrilla F

2017-09-01

During the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence Study was initiated to investigate this risk by assessing EBOV persistence in numerous body fluids of EVD survivors and providing risk reduction counseling based on test results for semen, vaginal fluid, menstrual blood, urine, rectal fluid, sweat, tears, saliva, and breast milk. This publication describes implementation of the counseling protocol and the key lessons learned. The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol was developed from a framework used to prevent transmission of HIV and other sexually transmitted infections. The framework helped to identify barriers to risk reduction and facilitated the development of a personalized risk-reduction plan, particularly around condom use and abstinence. Pre-test and post-test counseling sessions included risk reduction guidance, and post-test counseling was based on the participants' individual test results. The behavioral counseling protocol enabled study staff to translate the study's body fluid test results into individualized information for study participants. The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol provided guidance to mitigate the risk of EBOV transmission from EVD survivors. It has since been shared with and adapted by other EVD survivor body fluid testing programs and studies in Ebola-affected countries.

Using an Ecological Framework for Understanding and Treating Externalizing Behavior in Early Childhood

ERIC Educational Resources Information Center

Stacks, Ann M.

2005-01-01

This paper will review the literature on the rate, stability, and outcomes associated with externalizing behavior problems prior to kindergarten entry. Bronfenbrenner's (The ecology of human development. Cambridge, MA: Harvard University Press) ecological framework will be used to present the factors related to the onset and persistence of…

A comparative gradient approach as a tool for understanding and managing urban ecosystems

Treesearch

Christopher G. Boone; Elizabeth Cook; Sharon J. Hall; Marcia L. Nation; Nancy B. Grimm; Carol B. Raish; Deborah M. Finch; Abigail M. York

2012-01-01

To meet the grand challenges of the urban century - such as climate change, biodiversity loss, and persistent poverty - urban and ecological theory must contribute to integrated frameworks that treat social and ecological dynamics as interdependent. A socioecological framework that encapsulates theory from the social and ecological sciences will improve understanding...

Ties That Bind: A Social Network Approach to Understanding Student Integration and Persistence. ASHE Annual Meeting Paper.

ERIC Educational Resources Information Center

Thomas, Scott L.

This study examined the social networks of college students and how such networks affect student commitment and persistence. The study's theoretical framework was based on application of the social network paradigm to Tinto's Student Integration Model, in which a student's initial commitment is modified over time as a result of the student's…

Using resilience and resistance concepts to manage persistent threats to sagebrush ecosystems and greater sage-grouse

USGS Publications Warehouse

Chambers, Jeanne C.; Maestas, Jeremy D.; Pyke, David A.; Boyd, Chad S.; Pellant, Mike; Wuenschel, Amarina

2017-01-01

Conservation of imperiled species often demands addressing a complex suite of threats that undermine species viability. Regulatory approaches, such as the US Endangered Species Act (1973), tend to focus on anthropogenic threats through adoption of policies and regulatory mechanisms. However, persistent ecosystem-based threats, such as invasive species and altered disturbance regimes, remain critical issues for most at-risk species considered to be conservation-reliant. We describe an approach for addressing persistent ecosystem threats to at-risk species based on ecological resilience and resistance concepts that is currently being used to conserve greater sage-grouse (Centrocercus urophasianus)and sagebrush ecosystems. The approach links biophysical indicators of ecosystem resilience and resistance with species-specific population and habitat requisites in a risk-based framework to identify priority areas for management and guide allocation of resources to manage persistent ecosystem-based threats. US federal land management and natural resource agencies have adopted this framework as a foundation for prioritizing sage-grouse conservation resources and determining effective restoration and management strategies. Because threats and strategies to address them cross-cut program areas, an integrated approach that includes wildland fire operations, postfire rehabilitation, fuels management, and habitat restoration is being used. We believe this approach is applicable to species conservation in other largely intact ecosystems with persistent, ecosystem-based threats.

Parsing apart the persisters: Etiological mechanisms and criminal offense patterns of moderate- and high-level persistent offenders.

PubMed

Amemiya, Jamie; Vanderhei, Susan; Monahan, Kathryn C

2017-08-01

Longitudinal investigations that have applied Moffitt's dual taxonomic framework to criminal offending have provided support for the existence of adolescent-limited and life-course persistent antisocial individuals, but have also identified additional trajectories. For instance, rather than a single persistent trajectory, studies have found both high-level and moderate-level persistent offenders. To inform theory and progress our understanding of chronic antisocial behavior, the present study used a sample of serious adolescent offenders (N =1,088) followed from middle adolescence to early adulthood (14-25 years), and examined how moderate-level persistent offenders differed from low-rate, desisting, and high-level persistent offenders. Results indicated that moderate-level persisters' etiology and criminal offense patterns were most similar to high-level persisters, but there were notable differences. Specifically, increasing levels of contextual adversity characterized both moderate-level and high-level persisting trajectories, but moderate-level persisters reported consistently lower levels of environmental risk. While both high- and moderate-level persisters committed more drug-related offenses in early adulthood compared to adolescence, moderate-level persisters engaged in lower levels of antisocial behavior across all types of criminal offenses. Taken cumulatively, the findings of this study suggest that sociocontextual interventions may be powerful in reducing both moderate- and high-level persistence in crime.

Can earthworms survive fire retardants?

USGS Publications Warehouse

Beyer, W.N.; Olson, A.

1996-01-01

Most common fire retardants are foams or are similar to common agricultural fertilizers, such as ammonium sulfate and ammonium phosphate. Although fire retardants are widely applied to soils, we lack basic information about their toxicities to soil organisms. We measured the toxicity of five fire retardants (Firetrol LCG-R, Firetrol GTS-R, Silv-Ex Foam Concentrate, Phos-chek D-75, and Phos-chek WD-881) to earthworms using the pesticide toxicity test developed for earthworms by the European Economic Community. None was lethal at 1,000 ppm in the soil, which was suggested as a relatively high exposure under normal applications. We concluded that the fire retardants tested are relatively nontoxic to soil organisms compared with other environmental chemicals and that they probably do not reduce earthworm populations when applied under usual firefighting conditions.

Skin Temperatures During Unaided Egress: Unsuited and While Wearing the NASA Launch and Entry or Advanced Crew Escape Suits

NASA Technical Reports Server (NTRS)

Woodruff, Kristin K.; Lee, Stuart M. C.; Greenisen, Michael C.; Schneider, Suzanne M.

2000-01-01

The two flight suits currently worn by crew members during Shuttle launch and landing, the Launch and Entry Suit (LES) and the Advanced Crew Escape Suit (ACES), are designed to protect crew members in the case of emergency. Although the Liquid Cooling Garment (LCG) worn under the flight suits was designed to counteract the heat storage of the suits, the suits may increase thermal stress and limit the astronaut's egress capabilities. The purpose of this study was to assess the thermal loads experienced by crew members during a simulated emergency egress before and after spaceflight. Comparisons of skin temperatures were made between the preflight unsuited and suited conditions. between the pre- and postflight suited conditions, and between the two flight suits.

Unified Program Design: Organizing Existing Programming Models, Delivery Options, and Curriculum

ERIC Educational Resources Information Center

Rubenstein, Lisa DaVia; Ridgley, Lisa M.

2017-01-01

A persistent problem in the field of gifted education has been the lack of categorization and delineation of gifted programming options. To address this issue, we propose Unified Program Design as a structural framework for gifted program models. This framework defines gifted programs as the combination of delivery methods and curriculum models.…

University Students' Academic Performance: An Integrative Conceptual Framework and Empirical Analysis

ERIC Educational Resources Information Center

Fenollar, Pedro; Roman, Sergio; Cuestas, Pedro J.

2007-01-01

Background: The prediction and explanation of academic performance and the investigation of the factors relating to the academic success and persistence of students are topics of utmost importance in higher education. Aims: The main aim of the present study is to develop and test a conceptual framework in a university context, where the effects of…

Reciprocal Relations among Motivational Frameworks, Math Anxiety, and Math Achievement in Early Elementary School

ERIC Educational Resources Information Center

Gunderson, Elizabeth A.; Park, Daeun; Maloney, Erin A.; Beilock, Sian L.; Levine, Susan C.

2018-01-01

School-entry math achievement is a strong predictor of math achievement through high school. We asked whether reciprocal relations among math achievement, math anxiety, and entity motivational frameworks (believing that ability is fixed and a focus on performance) can help explain these persistent individual differences. We assessed 1st and 2nd…

Development of risk reduction behavioral counseling for Ebola virus disease survivors enrolled in the Sierra Leone Ebola Virus Persistence Study, 2015-2016

PubMed Central

Malik, Tasneem; Ariyarajah, Archchun; Ongpin, Patricia; Hogben, Matthew; McDonald, Suzanna L. R.; Marrinan, Jaclyn; Massaquoi, Thomas; Thorson, Anna; Ervin, Elizabeth; Bernstein, Kyle; Ross, Christine; Liu, William J.; Kroeger, Karen; Durski, Kara N.; Broutet, Nathalie; Knust, Barbara; Deen, Gibrilla F.

2017-01-01

Background During the 2014–2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence Study was initiated to investigate this risk by assessing EBOV persistence in numerous body fluids of EVD survivors and providing risk reduction counseling based on test results for semen, vaginal fluid, menstrual blood, urine, rectal fluid, sweat, tears, saliva, and breast milk. This publication describes implementation of the counseling protocol and the key lessons learned. Methodology/Principal findings The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol was developed from a framework used to prevent transmission of HIV and other sexually transmitted infections. The framework helped to identify barriers to risk reduction and facilitated the development of a personalized risk-reduction plan, particularly around condom use and abstinence. Pre-test and post-test counseling sessions included risk reduction guidance, and post-test counseling was based on the participants’ individual test results. The behavioral counseling protocol enabled study staff to translate the study’s body fluid test results into individualized information for study participants. Conclusions/Significance The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol provided guidance to mitigate the risk of EBOV transmission from EVD survivors. It has since been shared with and adapted by other EVD survivor body fluid testing programs and studies in Ebola-affected countries. PMID:28892490

Adapting cognitive behavioral therapy for psychosis for case managers: increasing access to services in a community mental health agency.

PubMed

Montesano, Vicki L; Sivec, Harry J; Munetz, Mark R; Pelton, Jeremy R; Turkington, Douglas

2014-03-01

The purpose of this article is twofold: (a) to describe the adaptation of an evidence-based practice and, (b) using a dissemination framework, to describe the process of implementing the practice at a community mental health agency. The authors describe the training concept and dissemination framework of implementing an emerging practice: high-yield cognitive behavioral techniques for psychosis, which is rooted in cognitive behavioral therapy. Thirteen case managers who represented teams from across the agency delivered the adapted practice at a community mental health agency. Implementation required buy in from all stakeholders, communication across disciplines, persistence, and flexibility. It appears that the use of a dissemination framework that is grounded in the literature, yet flexible, eases the process of implementing an adapted practice. Further research focusing on the effectiveness of this approach, along with the impact of implementing a full spectrum of cognitive behavioral therapy services for individuals with persistent psychotic symptoms, based on cognitive behavioral therapy principles, is indicated.

A Social-Cognitive-Ecological Framework for Understanding the Impact of Exposure to Persistent Ethnic-Political Violence on Children’s Psychosocial Adjustment

PubMed Central

Dubow, Eric F.; Huesmann, L. Rowell; Boxer, Paul

2009-01-01

In this article, we describe a theoretical framework for understanding how persistent and extreme exposure to ethnic-political conflict and violence interacts with cognitive, emotional, and self processes to influence children’s psychosocial adjustment. Three recent strands of theorizing guide our approach. First, we focus on how observational and social learning processes combine to influence the development of social-cognitive structures and processes that affect behavior. Second, we focus on the role of developing self and identity processes in shaping the child’s interactions with the world and the consequences of those interactions. Third, we build on the complex systems perspective on development and assume that human development can only be understood accurately by examining how the multiple contexts affecting children and the adults in their lives interact to moderate biosocial factors which predispose individuals to develop in certain directions. We review the recent empirical literature on children’s exposure to ethnic-political violence and we apply the social-cognitive-ecological framework to the empirical findings in this literature. Finally, we propose future directions for research and clinical implications derived from this framework. PMID:19430904

A social-cognitive-ecological framework for understanding the impact of exposure to persistent ethnic-political violence on children's psychosocial adjustment.

PubMed

Dubow, Eric F; Huesmann, L Rowell; Boxer, Paul

2009-06-01

In this article, we describe a theoretical framework for understanding how persistent and extreme exposure to ethnic-political conflict and violence interacts with cognitive, emotional, and self processes to influence children's psychosocial adjustment. Three recent strands of theorizing guide our approach. First, we focus on how observational and social learning processes combine to influence the development of social-cognitive structures and processes that affect behavior. Second, we focus on the role of developing self and identity processes in shaping the child's interactions with the world and the consequences of those interactions. Third, we build on the complex systems perspective on development and assume that human development can only be understood accurately by examining how the multiple contexts affecting children and the adults in their lives interact to moderate biosocial factors which predispose individuals to develop in certain directions. We review the recent empirical literature on children's exposure to ethnic-political violence and we apply the social-cognitive-ecological framework to the empirical findings in this literature. Finally, we propose future directions for research and clinical implications derived from this framework.

A General Framework of Persistence Strategies for Biological Systems Helps Explain Domains of Life

PubMed Central

Yafremava, Liudmila S.; Wielgos, Monica; Thomas, Suravi; Nasir, Arshan; Wang, Minglei; Mittenthal, Jay E.; Caetano-Anollés, Gustavo

2012-01-01

The nature and cause of the division of organisms in superkingdoms is not fully understood. Assuming that environment shapes physiology, here we construct a novel theoretical framework that helps identify general patterns of organism persistence. This framework is based on Jacob von Uexküll’s organism-centric view of the environment and James G. Miller’s view of organisms as matter-energy-information processing molecular machines. Three concepts describe an organism’s environmental niche: scope, umwelt, and gap. Scope denotes the entirety of environmental events and conditions to which the organism is exposed during its lifetime. Umwelt encompasses an organism’s perception of these events. The gap is the organism’s blind spot, the scope that is not covered by umwelt. These concepts bring organisms of different complexity to a common ecological denominator. Ecological and physiological data suggest organisms persist using three strategies: flexibility, robustness, and economy. All organisms use umwelt information to flexibly adapt to environmental change. They implement robustness against environmental perturbations within the gap generally through redundancy and reliability of internal constituents. Both flexibility and robustness improve survival. However, they also incur metabolic matter-energy processing costs, which otherwise could have been used for growth and reproduction. Lineages evolve unique tradeoff solutions among strategies in the space of what we call “a persistence triangle.” Protein domain architecture and other evidence support the preferential use of flexibility and robustness properties. Archaea and Bacteria gravitate toward the triangle’s economy vertex, with Archaea biased toward robustness. Eukarya trade economy for survivability. Protista occupy a saddle manifold separating akaryotes from multicellular organisms. Plants and the more flexible Fungi share an economic stratum, and Metazoa are locked in a positive feedback loop toward flexibility. PMID:23443991

Understanding the Dynamic Convergence Phenomenon from the Perspective of Diversity and Persistence: A Cross-Sector Comparative Analysis between the United States and South Korea.

PubMed

Shim, We; Kwon, Oh-Jin; Moon, Yeong-Ho; Kim, Keun-Hwan

2016-01-01

This study was designed to improve the explanation for the behavior of the phenomenon of technology convergence. The concepts and measurements of diversity and persistence, as inherent attributes of the phenomenon, were elaborated by reviewing different theories. Diversity was examined by analyzing the degree of capability to absorb heterogeneous technologies, while persistence was investigated by analyzing the degree of continuity in the usage of cumulated technologies. With these two dimensions, an analytic framework was proposed to compare the differences and dynamic patterns of convergence competence by countries at the technology sector level. Three major technology sectors in the United States and South Korea, namely, information and communication technology, biotechnology, and nanotechnology, were explored to explicitly illustrate the differences in technology convergence competence. The results show that although Korea has narrowed the differences of capabilities for technology convergence compared to the US, Korea not only has to continuously pursue the improvement of specialization for all three sectors, but also has to encourage the exploitation of different technology fields. The suggested framework and indicators allow for monitoring of the dynamic patterns of a technology sector and identifying the sources of the gaps. Thus, the framework and indicators are able to ensure the purpose of government innovation policy and to provide strategic directions for redistributing the proper combination of sources to accomplish technology convergence.

Understanding the Dynamic Convergence Phenomenon from the Perspective of Diversity and Persistence: A Cross-Sector Comparative Analysis between the United States and South Korea

PubMed Central

2016-01-01

This study was designed to improve the explanation for the behavior of the phenomenon of technology convergence. The concepts and measurements of diversity and persistence, as inherent attributes of the phenomenon, were elaborated by reviewing different theories. Diversity was examined by analyzing the degree of capability to absorb heterogeneous technologies, while persistence was investigated by analyzing the degree of continuity in the usage of cumulated technologies. With these two dimensions, an analytic framework was proposed to compare the differences and dynamic patterns of convergence competence by countries at the technology sector level. Three major technology sectors in the United States and South Korea, namely, information and communication technology, biotechnology, and nanotechnology, were explored to explicitly illustrate the differences in technology convergence competence. The results show that although Korea has narrowed the differences of capabilities for technology convergence compared to the US, Korea not only has to continuously pursue the improvement of specialization for all three sectors, but also has to encourage the exploitation of different technology fields. The suggested framework and indicators allow for monitoring of the dynamic patterns of a technology sector and identifying the sources of the gaps. Thus, the framework and indicators are able to ensure the purpose of government innovation policy and to provide strategic directions for redistributing the proper combination of sources to accomplish technology convergence. PMID:27416495

Women in engineering: A case study in preparation, persistence, and response

NASA Astrophysics Data System (ADS)

Winkelman, Colin Kim

This qualitative case study examined women students' perceptions of major influences on their successful completion of a Bachelor of Science degree in nine different disciplines of engineering. In-depth interviews were conducted with 13 female engineering students at an Institute of Technology over the period of a school year. The conceptual framework of analysis linked theoretical principles to categories of analysis that were correlated to three outcomes: preparation, persistence, and response. Emergent properties generated from in-depth interviews were then linked to the categories of preparation, interest-congruence, gender identity, social acceptance, campus culture, learning styles, classroom and faculty relations, sense of accomplishment, tokenism, career expectations, and family planning. Data collection was triangulated through individual interviews and a focus group with the 13 respondents and comparisons to quantitative research outcomes concerning self-confidence, persistence, satisfaction, and career expectations. The findings generally support the theories and propositions outlined in the conceptual framework constructed for this study. The most important of these findings include the impact of social conditioning on gender and academic preparation, the correlation of peer group relations to persistence, and the future expectations female students derive from their experiences over their 4 years of study. The data strongly suggest that traditional gender roles are a social conditioning process that can be overcome, permitting women to succeed in nontraditional academic career fields. Further research could build on these findings to explore social changes in attitudes about women engineers in the workplace, comparisons between men and women's persistence styles, and the importance of science and mathematics intervention programs for girls.

Persistent shoreline shape induced from offshore geologic framework: Effects of shoreface connected ridges

USGS Publications Warehouse

Safak, Ilgar; List, Jeffrey; Warner, John C.; Schwab, William C.

2017-01-01

Mechanisms relating offshore geologic framework to shoreline evolution are determined through geologic investigations, oceanographic deployments, and numerical modeling. Analysis of shoreline positions from the past 50 years along Fire Island, New York, a 50 km long barrier island, demonstrates a persistent undulating shape along the western half of the island. The shelf offshore of these persistent undulations is characterized with shoreface-connected sand ridges (SFCR) of a similar alongshore length scale, leading to a hypothesis that the ridges control the shoreline shape through the modification of flow. To evaluate this, a hydrodynamic model was configured to start with the US East Coast and scale down to resolve the Fire Island nearshore. The model was validated using observations along western Fire Island and buoy data, and used to compute waves, currents and sediment fluxes. To isolate the influence of the SFCR on the generation of the persistent shoreline shape, simulations were performed with a linearized nearshore bathymetry to remove alongshore transport gradients associated with shoreline shape. The model accurately predicts the scale and variation of the alongshore transport that would generate the persistent shoreline undulations. In one location, however, the ridge crest connects to the nearshore and leads to an offshore-directed transport that produces a difference in the shoreline shape. This qualitatively supports the hypothesized effect of cross-shore fluxes on coastal evolution. Alongshore flows in the nearshore during a representative storm are driven by wave breaking, vortex force, advection and pressure gradient, all of which are affected by the SFCR.

Trials and Tribulations of Protecting Children from Environmental Hazards

PubMed Central

Lanphear, Bruce P.; Paulson, Jerome; Beirne, Sandra

2006-01-01

Society is increasingly aware of the profound impact that the environment has on children’s health. Not surprisingly, there is increasing public scrutiny about children’s exposures to environmental hazards, especially for disadvantaged children. These trends underscore the ethical imperative to develop a framework to protect children from environmental hazards. Such a framework must include regulations to test new chemicals and other potential hazards before they are marketed, a strategy to conduct research necessary to protect children from persistent hazards that are widely dispersed in their environment, stronger regulatory mechanisms to eliminate human exposures to recognized or suspected toxicants, and guidelines about the ethical conduct of research and the role of experimental trials that test the efficacy and safety of interventions to prevent or ameliorate children’s exposure to persistent toxicants or hazards that are widely dispersed in their environment. PMID:17035151

Persistence as the path from motivation to performance in the Papua New Guinea health sector.

PubMed

Elich, Luke

2009-01-01

This paper considers how the individual capacity states of motivation, confidence, skill and ability relate to performance, and identifies a crucial role for the discretionary behaviour of individuals: specifically, employee persistence and innovation. The study Understanding the people and performance link: unlocking the black box undertaken by Purcell and colleagues is relied upon in constructing a theoretical framework for the conceptual interrelationships between performance and the human-resource-mediating variables, which is then applied within the Papua New Guinea (PNG) health sector context. The study by Purcell and colleagues, which was informed by organizations with well-developed and functioning human resource policies and practices, is distinguished from the PNG health sector, where human resource frameworks are largely ineffective--yet it is determined that the importance of 'discretionary behaviour' relative to performance, whilst varied, is undiminished.

Stories from the field: Teaching science in low-performing, rural schools

NASA Astrophysics Data System (ADS)

Conetta, Patrick John

If teachers matter to the academic success of students, then having experienced teachers shows significant promise in eliminating persistent achievement gaps. However, high rates of teacher attrition are persistent in schools serving low-income and minority students serving to reinforce these persistent gaps. The purpose of this study is to allow the voices of science teachers working in low-performing, rural schools to be heard and expand our current understanding of teacher retention beyond "yes" or "no" decisions. The narratives teachers share demonstrate that persistence is constructed daily through frustrations and hard-won victories that are significant to one's career decisions. With an ear for the structures that guide teacher's practice and create professional tension, teacher narratives also represent hope for the subtle and splendid ways they challenge these tensions to carve out their existence as educators. Their stories are inspirational to future teachers and teacher educators because they provide insights to the ways teachers learn to persist. My research was guided by three general interests: What experiences bring individuals to teach science in hard to staff schools, what conditions did teachers find when they arrived, and how do science teachers respond to the circumstances in which they find themselves teaching. Steered by Holland, Lachicotte, Skinner, and Cain's (1998) theoretical framework of Figured Worlds, and inspired by previous work utilizing this framework, I gathered data through extended interviews with nine participants and examined their stories through qualitative narrative analysis to illustrate the delicate interplay between structure and agency and how this interplay is intertwined with teachers' willingness to persist. This study revealed that individual willingness to persist was interwoven with their ability to author themselves within and/or against existing cultural models of the "good teacher" and its implications lead to a more sophisticated understanding of working conditions by illuminating how cultural models of "good teacher" are (re)produced in hard-to-staff schools. Additionally, the results demonstrate opportunities, beyond attrition, individuals leverage to align themselves with or contest cultural models to encourage their willingness to persist.

The Persistence and Importance of Patriotism in the All-Volunteer Force

DTIC Science & Technology

1982-12-13

The description is cast in a theoretical framework which challenges the wisdom of focusing primarily on levels of pay and other market oriented conditions of work when establishing military manpower policy.

Integrating Subjective Trust into Networked Infrastructures

DTIC Science & Technology

2009-04-22

architectural framework for hexperimenting wit trust. • Use of semantic technologies incorporated into h b id b d t t t ta y r - ase rus managemen ...Language for Operation PI Persistent Identifier PILOW P i t t Id tifi T blers s en en er a es PINL Persistent Identifier Networking Layer SBIR Small...Investigate and propose an architecture to determine/measure and convey th t t l l f th i l t ie rus eve o e var ous e emen s n a distributed or

Crossover from antipersistent to persistent behavior in time series possessing the generalyzed dynamic scaling law

NASA Astrophysics Data System (ADS)

Balankin, Alexander S.; Morales Matamoros, Oswaldo; Gálvez M., Ernesto; Pérez A., Alfonso

2004-03-01

The behavior of crude oil price volatility is analyzed within a conceptual framework of kinetic roughening of growing interfaces. We find that the persistent long-horizon volatilities satisfy the Family-Viscek dynamic scaling ansatz, whereas the mean-reverting in time short horizon volatilities obey the generalized scaling law with continuously varying scaling exponents. Furthermore we find that the crossover from antipersistent to persistent behavior is accompanied by a change in the type of volatility distribution. These phenomena are attributed to the complex avalanche dynamics of crude oil markets and so a similar behavior may be observed in a wide variety of physical systems governed by avalanche dynamics.

F-15 Avionics Test Station and Component Specialist Career Ladder. Occupational Survey Report

DTIC Science & Technology

1990-02-01

Or ko m qdl U(. NL ) ULU 0Z M-: 0 C) Z: -3 F M C- OC>mC I - oL D, V) C)L )C- O C) o Or- F ) j CRd jMm i CDd L.L CD C) .0 C) V)= .00 U~00 LUU off0.0...LO C CO UJ LI(4 .00 r" r r"~i ell ko 1 C I" C) 4 -4 C’J C3 C CD V) 𔃾A ~ C) CC F-4 LU< Q-C =D F-( Ln J(I -4C Cr- 1-d C C C C C) C> C C d >- LL EL-C...CONSOLIDATED TOOL KITS (CTK) AND TOOL ROOM CHITS 68 H291 ISOLATE MALFUNCTIONS WITHIN LEAD COMPUTING GYRO (LCG) LRUs 66 F189 INTERPRET SYSTEM DIAGRAMS OR

The existence of inflection points for generalized log-aesthetic curves satisfying G1 data

NASA Astrophysics Data System (ADS)

Karpagavalli, R.; Gobithaasan, R. U.; Miura, K. T.; Shanmugavel, Madhavan

2015-12-01

Log-Aesthetic (LA) curves have been implemented in a CAD/CAM system for various design feats. LA curves possess linear Logarithmic Curvature Graph (LCG) with gradient (shape parameter) denoted as α. In 2009, a generalized form of LA curves called Generalized Log-Aesthetic Curves (GLAC) has been proposed which has an extra shape parameter as ν compared to LA curves. Recently, G1 continuous GLAC algorithm has been proposed which utilizes the extra shape parameter using four control points. This paper discusses on the existence of inflection points in a GLAC segment satisfying G1 Hermite data and the effect of inflection point on convex hull property. It is found that the existence of inflection point can be avoided by manipulating the value of α. Numerical experiments show that the increase of α may remove the inflection point (if any) in a GLAC segment.

Swelling of biological and semiflexible polyelectrolytes.

PubMed

Dobrynin, Andrey V; Carrillo, Jan-Michael Y

2009-10-21

We have developed a theoretical model of swelling of semiflexible (biological) polyelectrolytes in salt solutions. Our approach is based on separation of length scales which allowed us to split a chain's electrostatic energy into two parts that describe local and remote electrostatic interactions along the polymer backbone. The local part takes into account interactions between charged monomers that are separated by distances along the polymer backbone shorter than the chain's persistence length. These electrostatic interactions renormalize chain persistence length. The second part includes electrostatic interactions between remote charged pairs along the polymer backbone located at distances larger than the chain persistence length. These interactions are responsible for chain swelling. In the framework of this approach we calculated effective chain persistence length and chain size as a function of the Debye screening length, chain degree of ionization, bare persistence length and chain degree of polymerization. Our crossover expression for the effective chain's persistence length is in good quantitative agreement with the experimental data on DNA. We have been able to fit experimental datasets by using two adjustable parameters: DNA ionization degree (α = 0.15-0.17) and a bare persistence length (l(p) = 40-44 nm).

An Examination of the Ability of High School Wealth and Academic Preparation to Predict First Year Retention of African American and White Students Enrolled in the North Carolina Community College System Associate Degree of Nursing Programs

ERIC Educational Resources Information Center

Patton, Bess Llewellyn

2016-01-01

The framework for this study used Tinto's (1975) theoretical framework for student persistence and incorporated the examination of high school wealth, the absence of poverty, as measured by the percentage of students receiving Federal Free and Reduced Lunch, along with North Carolina Department of Public School performance measures, academic…

Influence of temperature, filter wettability, and timing of filtration on the removal of WBCs from RBC concentrates.

PubMed

van der Meer, P F; Pietersz, R N; Reesink, H W

2001-04-01

The efficacy of the removal of WBCs from buffy coat-reduced RBC concentrates by filtration is determined by many variables. The aim of this study was to investigate the influence of the filtration temperature, the wettability of the filter material, and the timing of the filtration after collection. The investigation used commercially available filters: 3 dry "online" filters (Cellselect FR, Fresenius Hemocare; BioR-01-max, Fresenius; Leucoflex LCG1, MacoPharma) and one wet "inline" filter (Leucoflex LCR4, MacoPharma) that contained saline-adenine-glucose-mannitol additive solution for RBCs and differed from the online version only in wettability. After buffy coat removal and suspension in saline-adenine-glucose-mannitol, filtrations were performed immediately at room temperature (RT) and after 2 hours' storage of the RBC concentrates at 4 degrees C, while the Leucoflex LCR4 was also tested after 24 hours' storage of the RBC concentrates at 4 degrees C. Sets of 12 pooled experiments were performed to prevent donor-dependent differences. The Cellselect FR gave significantly better WBC removal from RBC concentrates at 4 degrees C than at RT, with residual WBCs of 1.44 +/- 0.58 x 10(6) and 2.78 +/- 1.23 x 10(6), respectively (p<0.001). The BioR-01-max gave no significant difference: 0.62 +/- 0.27 x 10(6) WBCs (at 4 degrees C) versus 0.61 +/- 0.25 x 10(6) WBCs (at RT). Filtration with the Leucoflex LCG1 resulted in 0.06 +/- 0.03 x 10(6) and 0.07 +/- 0.07 x 10(6) WBCs at 4 degrees C and RT, respectively, which is not a significant difference. The Leucoflex LCR4, however, gave 2.08 +/- 0.84 x 10(6) WBCs at RT, 0.52 +/- 0.44 x 10(6) WBCs at 4 degrees C after 2 hours' cooling, and 0.05 +/- 0.10 x 10(6) WBCs at 4 degrees C after 24 hours' cooling (all p<0.001). Temperature, filter wettability, and timing of filtration after collection influence the efficacy of a filter for RBC concentrates. These variables need to be established, validated, and controlled before a filter can be selected for routine use.

What Determines the Duration of War? Insights from Assessment Strategies in Animal Contests

PubMed Central

Briffa, Mark

2014-01-01

Interstate wars and animal contests both involve disputed resources, restraint and giving up decisions. In both cases it seems illogical for the weaker side to persist in the conflict if it will eventually lose. In the case of animal contests analyses of the links between opponent power and contest duration have provided insights into what sources of information are available to fighting animals. I outline the theory of information use during animal contests and describe a statistical framework that has been used to distinguish between two strategies that individuals use to decide whether to persist or quit. I then apply this framework to the analysis of interstate wars. War duration increases with the power of winners and losers. These patterns provide no support for the idea that wars are settled on the basis of mutual assessment of capabilities but indicate that settlement is based on attrition. In contrast to most animal contests, war duration is as closely linked to the power of the winning side as to that of the losing side. Overall, this analysis highlights a number of similarities between animal contests and interstate war, indicating that both could be investigated using similar conceptual frameworks. PMID:25247403

Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour

PubMed Central

Wynn, Michelle L.; Kulesa, Paul M.; Schnell, Santiago

2012-01-01

Follow-the-leader chain migration is a striking cell migratory behaviour observed during vertebrate development, adult neurogenesis and cancer metastasis. Although cell–cell contact and extracellular matrix (ECM) cues have been proposed to promote this phenomenon, mechanisms that underlie chain migration persistence remain unclear. Here, we developed a quantitative agent-based modelling framework to test mechanistic hypotheses of chain migration persistence. We defined chain migration and its persistence based on evidence from the highly migratory neural crest model system, where cells within a chain extend and retract filopodia in short-lived cell contacts and move together as a collective. In our agent-based simulations, we began with a set of agents arranged as a chain and systematically probed the influence of model parameters to identify factors critical to the maintenance of the chain migration pattern. We discovered that chain migration persistence requires a high degree of directional bias in both lead and follower cells towards the target. Chain migration persistence was also promoted when lead cells maintained cell contact with followers, but not vice-versa. Finally, providing a path of least resistance in the ECM was not sufficient alone to drive chain persistence. Our results indicate that chain migration persistence depends on the interplay of directional cell movement and biased cell–cell contact. PMID:22219399

Quantifying the degree of persistence in random amoeboid motion based on the Hurst exponent of fractional Brownian motion.

PubMed

Makarava, Natallia; Menz, Stephan; Theves, Matthias; Huisinga, Wilhelm; Beta, Carsten; Holschneider, Matthias

2014-10-01

Amoebae explore their environment in a random way, unless external cues like, e.g., nutrients, bias their motion. Even in the absence of cues, however, experimental cell tracks show some degree of persistence. In this paper, we analyzed individual cell tracks in the framework of a linear mixed effects model, where each track is modeled by a fractional Brownian motion, i.e., a Gaussian process exhibiting a long-term correlation structure superposed on a linear trend. The degree of persistence was quantified by the Hurst exponent of fractional Brownian motion. Our analysis of experimental cell tracks of the amoeba Dictyostelium discoideum showed a persistent movement for the majority of tracks. Employing a sliding window approach, we estimated the variations of the Hurst exponent over time, which allowed us to identify points in time, where the correlation structure was distorted ("outliers"). Coarse graining of track data via down-sampling allowed us to identify the dependence of persistence on the spatial scale. While one would expect the (mode of the) Hurst exponent to be constant on different temporal scales due to the self-similarity property of fractional Brownian motion, we observed a trend towards stronger persistence for the down-sampled cell tracks indicating stronger persistence on larger time scales.

On species persistence-time distributions.

PubMed

Suweis, S; Bertuzzo, E; Mari, L; Rodriguez-Iturbe, I; Maritan, A; Rinaldo, A

2012-06-21

We present new theoretical and empirical results on the probability distributions of species persistence times in natural ecosystems. Persistence times, defined as the timespans occurring between species' colonization and local extinction in a given geographic region, are empirically estimated from local observations of species' presence/absence. A connected sampling problem is presented, generalized and solved analytically. Species persistence is shown to provide a direct connection with key spatial macroecological patterns like species-area and endemics-area relationships. Our empirical analysis pertains to two different ecosystems and taxa: a herbaceous plant community and a estuarine fish database. Despite the substantial differences in ecological interactions and spatial scales, we confirm earlier evidence on the general properties of the scaling of persistence times, including the predicted effects of the structure of the spatial interaction network. The framework tested here allows to investigate directly nature and extent of spatial effects in the context of ecosystem dynamics. The notable coherence between spatial and temporal macroecological patterns, theoretically derived and empirically verified, is suggested to underlie general features of the dynamic evolution of ecosystems. Copyright © 2012 Elsevier Ltd. All rights reserved.

The social transmission of metacontrol policies: Mechanisms underlying the interpersonal transfer of persistence and flexibility.

PubMed

Hommel, Bernhard; Colzato, Lorenza S

2017-10-01

Humans often face binary cognitive-control dilemmas, with the choice between persistence and flexibility being a crucial one. Tackling these dilemmas requires metacontrol, i.e., the control of the current cognitive-control policy. As predicted from functional, psychometric, neuroscientific, and modeling approaches, interindividual variability in metacontrol biases towards persistence or flexibility could be demonstrated in metacontrol-sensitive tasks. These biases covary systematically with genetic predispositions regarding mesofrontal and nigrostriatal dopaminergic functioning and the individualistic or collectivistic nature of the cultural background. However, there is also evidence for mood- and meditation-induced intraindividual variability (with negative mood and focused-attention meditation being associated with a bias towards persistence, and positive mood and open-monitoring meditation being associated with a bias towards flexibility), suggesting that genetic and cultural factors do not determine metacontrol settings entirely. We suggest a theoretical framework that explains how genetic predisposition and cultural learning can lead to the implementation of metacontrol defaults, which however can be shifted towards persistence or flexibility by situational factors. Copyright © 2017 Elsevier Ltd. All rights reserved.

Persistent-random-walk approach to anomalous transport of self-propelled particles

NASA Astrophysics Data System (ADS)

Sadjadi, Zeinab; Shaebani, M. Reza; Rieger, Heiko; Santen, Ludger

2015-06-01

The motion of self-propelled particles is modeled as a persistent random walk. An analytical framework is developed that allows the derivation of exact expressions for the time evolution of arbitrary moments of the persistent walk's displacement. It is shown that the interplay of step length and turning angle distributions and self-propulsion produces various signs of anomalous diffusion at short time scales and asymptotically a normal diffusion behavior with a broad range of diffusion coefficients. The crossover from the anomalous short-time behavior to the asymptotic diffusion regime is studied and the parameter dependencies of the crossover time are discussed. Higher moments of the displacement distribution are calculated and analytical expressions for the time evolution of the skewness and the kurtosis of the distribution are presented.

Beyond Individual Effectiveness: Conceptualizing Organizational Leadership for Equity

ERIC Educational Resources Information Center

Ishimaru, Ann M.; Galloway, Mollie K.

2014-01-01

Despite increasing policy focus on individual leadership effectiveness, the literature offers limited guidance regarding how organizational leadership might address persistent opportunity and outcome disparities by student race, class, ethnicity, home language, and/or ability. We propose a conceptual framework of equitable leadership practice,…

Addressing barriers to the prevention, diagnosis and treatment of hepatitis B and C in the face of persisting fiscal constraints in Europe: report from a high level conference.

PubMed

Papatheodoridis, G; Thomas, H C; Golna, C; Bernardi, M; Carballo, M; Cornberg, M; Dalekos, G; Degertekin, B; Dourakis, S; Flisiak, R; Goldberg, D; Gore, C; Goulis, I; Hadziyannis, S; Kalamitsis, G; Kanavos, P; Kautz, A; Koskinas, I; Leite, B R; Malliori, M; Manolakopoulos, S; Matičič, M; Papaevangelou, V; Pirona, A; Prati, D; Raptopoulou-Gigi, M; Reic, T; Robaeys, G; Schatz, E; Souliotis, K; Tountas, Y; Wiktor, S; Wilson, D; Yfantopoulos, J; Hatzakis, A

2016-02-01

In the WHO-EURO region, around 28 million people are currently living with chronic viral hepatitis, and 120,000 people die every year because of it. Lack of awareness and understanding combined with the social stigma and discrimination exacerbate barriers related to access to prevention, diagnosis and treatment services for those most in need. In addition, the persisting economic crisis has impacted on public health spending, thus posing challenges on the sustainable investment in promotion, primary and secondary prevention, diagnosis and treatment of viral hepatitis across European countries. The Hepatitis B and C Public Policy Association in cooperation with the Hellenic Center for Disease Prevention and Control together with 10 partner organizations discussed at the Athens High Level Meeting held in June 2014 recent policy developments, persisting and emerging challenges related to the prevention and management of viral hepatitis and the need for a de minimis framework of urgent priorities for action, reflected in a Call to Action (Appendix S1). The discussion confirmed that persisting barriers do not allow the full realisation of the public health potential of diagnosing and preventing hepatitis B and C, treating hepatitis B and curing hepatitis C. Such barriers are related to (a) lack of evidence-based knowledge of hepatitis B and C, (b) limited access to prevention, diagnosis and treatment services with poor patient pathways, (c) declining resources and (d) the presence of social stigma and discrimination. The discussion also confirmed the emerging importance of fiscal constraints on the ability of policymakers to adequately address viral hepatitis challenges, particularly through increasing coverage of newer therapies. In Europe, it is critical that public policy bodies urgently agree on a conceptual framework for addressing the existing and emerging barriers to managing viral hepatitis. Such a framework would ensure all health systems share a common understanding of definitions and indicators and look to integrate their responses to manage policy spillovers in the most cost-effective manner, while forging wide partnerships to sustainably and successfully address viral hepatitis. © 2016 John Wiley & Sons Ltd.

Persistent recruitment of somatosensory cortex during active maintenance of hand images in working memory.

PubMed

Galvez-Pol, A; Calvo-Merino, B; Capilla, A; Forster, B

2018-07-01

Working memory (WM) supports temporary maintenance of task-relevant information. This process is associated with persistent activity in the sensory cortex processing the information (e.g., visual stimuli activate visual cortex). However, we argue here that more multifaceted stimuli moderate this sensory-locked activity and recruit distinctive cortices. Specifically, perception of bodies recruits somatosensory cortex (SCx) beyond early visual areas (suggesting embodiment processes). Here we explore persistent activation in processing areas beyond the sensory cortex initially relevant to the modality of the stimuli. Using visual and somatosensory evoked-potentials in a visual WM task, we isolated different levels of visual and somatosensory involvement during encoding of body and non-body-related images. Persistent activity increased in SCx only when maintaining body images in WM, whereas visual/posterior regions' activity increased significantly when maintaining non-body images. Our results bridge WM and embodiment frameworks, supporting a dynamic WM process where the nature of the information summons specific processing resources. Copyright © 2018 Elsevier Inc. All rights reserved.

Recognizing potential barriers to setting and achieving effective rehabilitation goals for patients with persistent pain.

PubMed

Schmidt, Stephen G

2016-07-01

Although the process of goal setting in rehabilitation of individuals with persistent pain is considered a fundamental and requisite skill, it is frequently reported as a challenging element of clinical practice. Factors which may contribute to the complexity of goal setting include the potential for unrecognized shifts in cognitive function, psychological comorbidities, and the social context of both providers and patients. This review aims to describe factors which may confound the process of setting and achieving collaborative rehabilitation goals using a biopsychosocial framework and to provide recommendations to enhance goal setting effectiveness.

Brain differences between persistent and remitted attention deficit hyperactivity disorder.

PubMed

Mattfeld, Aaron T; Gabrieli, John D E; Biederman, Joseph; Spencer, Thomas; Brown, Ariel; Kotte, Amelia; Kagan, Elana; Whitfield-Gabrieli, Susan

2014-09-01

Previous resting state studies examining the brain basis of attention deficit hyperactivity disorder have not distinguished between patients who persist versus those who remit from the diagnosis as adults. To characterize the neurobiological differences and similarities of persistence and remittance, we performed resting state functional magnetic resonance imaging in individuals who had been longitudinally and uniformly characterized as having or not having attention deficit hyperactivity disorder in childhood and again in adulthood (16 years after baseline assessment). Intrinsic functional brain organization was measured in patients who had a persistent diagnosis in childhood and adulthood (n = 13), in patients who met diagnosis in childhood but not in adulthood (n = 22), and in control participants who never had attention deficit hyperactivity disorder (n = 17). A positive functional correlation between posterior cingulate and medial prefrontal cortices, major components of the default-mode network, was reduced only in patients whose diagnosis persisted into adulthood. A negative functional correlation between medial and dorsolateral prefrontal cortices was reduced in both persistent and remitted patients. The neurobiological dissociation between the persistence and remittance of attention deficit hyperactivity disorder may provide a framework for the relation between the clinical diagnosis, which indicates the need for treatment, and additional deficits that are common, such as executive dysfunctions. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

An Integrated Modeling Framework Forecasting Ecosystem Exposure— A Systems Approach to the Cumulative Impacts of Multiple Stressors

EPA Science Inventory

Freshwater habitats provide fishable, swimmable and drinkable resources and are a nexus of geophysical and biological processes. These processes in turn influence the persistence and sustainability of populations, communities and ecosystems. Climate change and landuse change enco...

Uneven Terrain: Educational Policy and Equity in Nepal

ERIC Educational Resources Information Center

Shields, Robin; Rappleye, Jeremy

2008-01-01

This paper investigates the relationship between educational policy, equity, and national development in Nepal. It argues that current inequities in educational opportunities and outcomes are largely attributable to persistent inequities and biases in the educational policy framework. We begin by surveying the complex, multifaceted reality of…

A Strategic Racial Equity Framework

ERIC Educational Resources Information Center

Garces, Liliana M.; Gordon da Cruz, Cynthia

2017-01-01

Despite the achievement of key civil rights milestones, as well as growing public awareness and concern, educational inequities for students of color and other historically marginalized students continue to persist throughout the U.S. educational system (Aud, Fox, & KewalRamani, 2010). The pursuit of educational equity has often been achieved…

A pluggable framework for parallel pairwise sequence search.

PubMed

Archuleta, Jeremy; Feng, Wu-chun; Tilevich, Eli

2007-01-01

The current and near future of the computing industry is one of multi-core and multi-processor technology. Most existing sequence-search tools have been designed with a focus on single-core, single-processor systems. This discrepancy between software design and hardware architecture substantially hinders sequence-search performance by not allowing full utilization of the hardware. This paper presents a novel framework that will aid the conversion of serial sequence-search tools into a parallel version that can take full advantage of the available hardware. The framework, which is based on a software architecture called mixin layers with refined roles, enables modules to be plugged into the framework with minimal effort. The inherent modular design improves maintenance and extensibility, thus opening up a plethora of opportunities for advanced algorithmic features to be developed and incorporated while routine maintenance of the codebase persists.

Six components observations of local earthquakes during the 2016 Central Italy seismic sequence

NASA Astrophysics Data System (ADS)

Simonelli, A.; Bernauer, F.; Chow, B.; Braun, T.; Wassermann, J. M.; Igel, H.

2017-12-01

For many years the seismological community has looked for a reliable, sensitive, broadband three-component portable rotational sensor. In this preliminary study, we show the possibility of measuring and extracting relevant seismological information from local earthquakes. We employ portable three-component rotational sensors, insensitive to translations, which operate on optical interferometry principles (Sagnac effect). Multiple sensors recording redundantly add significance to the measurements.During the Central Italy seismic sequence in November 2016, we deployed two portable fiber-optic gyroscopes (BlueSeis3A from iXBlue and LCG demonstrator from LITEF) and a broadband seismometer in Colfiorito, Italy. We present here the six-component observations, with analysis of rotational (three redundant components) and translational (three components) ground motions, generated by earthquakes at local distances. For each seismic event, we compare coherence between rotational sensors and estimate a back azimuth consistent with theoretical values. We also estimate Love and Rayleigh wave phase velocities in the 5 to 10 Hz frequency range.

A JEE RESTful service to access Conditions Data in ATLAS

NASA Astrophysics Data System (ADS)

Formica, Andrea; Gallas, E. J.

2015-12-01

Usage of condition data in ATLAS is extensive for offline reconstruction and analysis (e.g. alignment, calibration, data quality). The system is based on the LCG Conditions Database infrastructure, with read and write access via an ad hoc C++ API (COOL), a system which was developed before Run 1 data taking began. The infrastructure dictates that the data is organized into separate schemas (assigned to subsystems/groups storing distinct and independent sets of conditions), making it difficult to access information from several schemas at the same time. We have thus created PL/SQL functions containing queries to provide content extraction at multi-schema level. The PL/SQL API has been exposed to external clients by means of a Java application providing DB access via REST services, deployed inside an application server (JBoss WildFly). The services allow navigation over multiple schemas via simple URLs. The data can be retrieved either in XML or JSON formats, via simple clients (like curl or Web browsers).

Toxicity of fire retardant chemicals to aquatic organisms: Progress report

USGS Publications Warehouse

Hamilton, Steven J.; McDonald, Susan F.; Gaikowski, Mark P.; Buhl, Kevin J.; Ramsey, G.S.

1996-01-01

Fire retardants and suppressants used extensively in North America are often applied in environmentally sensitive areas that may contain endangered, threatened, or economically important plant and animal species. We conducted laboratory acute toxicity tests in both hard and soft waters with five commonly used fire control chemicals (Fire Trol LCG-R, Fire-Trol GTS-R, Phos-Chek D-75-F, Phos-Chek WD-881, and Silv-Ex). Organisms used in the tests included two fish (rainbow trout and fathead minnow), two aquatic invertebrates (Daphnia magna and Hyalella azteca), and a green algae (Selenastrum capricornutum). In general, the green algae was substantially more sensitive to the three non-foam fire chemicals than the animals, the Daphnia were the most sensitive test organism in exposures with foams. The two foams (Silv-Ex and Phos-Chek WD-881) had similar toxicity and were more toxic than the three non-foams. Water quality did not seem to modify the toxicity of the five fire chemicals in a consistent manner.

Rational temporal predictions can underlie apparent failures to delay gratification.

PubMed

McGuire, Joseph T; Kable, Joseph W

2013-04-01

An important category of seemingly maladaptive decisions involves failure to postpone gratification. A person pursuing a desirable long-run outcome may abandon it in favor of a short-run alternative that has been available all along. Here we present a theoretical framework in which this seemingly irrational behavior emerges from stable preferences and veridical judgments. Our account recognizes that decision makers generally face uncertainty regarding the time at which future outcomes will materialize. When timing is uncertain, the value of persistence depends crucially on the nature of a decision maker's prior temporal beliefs. Certain forms of temporal beliefs imply that a delay's predicted remaining length increases as a function of time already waited. In this type of situation, the rational, utility-maximizing strategy is to persist for a limited amount of time and then give up. We show empirically that people's explicit predictions of remaining delay lengths indeed increase as a function of elapsed time in several relevant domains, implying that temporal judgments offer a rational basis for limiting persistence. We then develop our framework into a simple working model and show how it accounts for individual differences in a laboratory task (the well-known "marshmallow test"). We conclude that delay-of-gratification failure, generally viewed as a manifestation of limited self-control capacity, can instead arise as an adaptive response to the perceived statistics of one's environment.

Cultural context and a critical approach to eliminating health disparities.

PubMed

Griffith, Derek M; Johnson, Jonetta; Ellis, Katrina R; Schulz, Amy Jo

2010-01-01

The science of eliminating racial health disparities requires a clear understanding of the underlying social processes that drive persistent differences in health outcomes by self-identified race. Understanding these social processes requires analysis of cultural notions of race as these are instantiated in institutional policies and practices that ultimately contribute to health disparities. Racism provides a useful framework for understanding how social, political and economic factors directly and indirectly influence health outcomes. While it is important to capture how individuals are influenced by their psychological experience of prejudice and discrimination, racism is more than an intrapersonal or interpersonal variable. Considerable attention has focused on race-based residential segregation and other forms of institutional racism but less focus has been placed on how cultural values, frameworks and meanings shape institutional policies and practices. In this article, we highlight the intersection of cultural and institutional racism as a critical mechanism through which racial inequities in social determinants of health not only develop but persist. This distinction highlights and helps to explain processes and structures that contribute to racial disparities persisting across time and outcomes. Using two historical examples, the National Negro Health Movement and hospital desegregation during the Civil Rights Era, we identify key questions that an analysis of cultural racism might add to the more common focus on overt policy decisions and practices.

Examination of Longitudinal Invariance on a Framework for Observing and Categorizing Instructional Strategies

NASA Astrophysics Data System (ADS)

Ryoo, Ji Hoon; Tai, Robert H.; Skeeles-Worley, Angela D.

2018-02-01

In longitudinal studies, measurement invariance is required to conduct substantive comparisons over time or across groups. In this study, we examined measurement invariance on a recently developed instrument capturing student preferences for seven instructional strategies related to science learning and career interest. We have labeled these seven instructional strategies as Collaborating, Competing, Caretaking, Creating/Making, Discovering, Performing, and Teaching. A better understanding of student preferences for particular instructional strategies can help educators, researchers, and policy makers deliberately tailor programmatic instructional structure to increase student persistence in the STEM pipeline. However, simply confirming the relationship between student preferences for science instructional strategies and their future career choices at a single time point is not sufficient to clarify our understanding of the relationship between instructional strategies and student persistence in the STEM pipeline, especially since preferences for instructional strategies are understood to vary over time. As such, we sought to develop a measure that invariantly captures student preference over a period of time: the Framework for Observing and Categorizing Instructional Strategies (FOCIS). We administered the FOCIS instrument over four semesters over two middle school grades to 1009 6th graders and 1021 7th graders and confirmed the longitudinal invariance of the FOCIS measure. This confirmation of longitudinal invariance will allow researchers to examine the relationship between student preference for certain instructional strategies and student persistence in the STEM pipeline.

Rational temporal predictions can underlie apparent failures to delay gratification

PubMed Central

McGuire, Joseph T.; Kable, Joseph W.

2013-01-01

An important category of seemingly maladaptive decisions involves failure to postpone gratification. A person pursuing a desirable long-run outcome may abandon it in favor of a short-run alternative that has been available all along. Here we present a theoretical framework in which this seemingly irrational behavior emerges from stable preferences and veridical judgments. Our account recognizes that decision makers generally face uncertainty regarding the time at which future outcomes will materialize. When timing is uncertain, the value of persistence depends crucially on the nature of a decision-maker’s prior temporal beliefs. Certain forms of temporal beliefs imply that a delay’s predicted remaining length increases as a function of time already waited. In this type of situation, the rational, utility-maximizing strategy is to persist for a limited amount of time and then give up. We show empirically that people’s explicit predictions of remaining delay lengths indeed increase as a function of elapsed time in several relevant domains, implying that temporal judgments offer a rational basis for limiting persistence. We then develop our framework into a simple working model and show how it accounts for individual differences in a laboratory task (the well-known “marshmallow test”). We conclude that delay-of-gratification failure, generally viewed as a manifestation of limited self-control capacity, can instead arise as an adaptive response to the perceived statistics of one’s environment. PMID:23458085

Persistent Identifiers: a Prerequisite to Establish the Framework for Scholarly Link Exchange—Scholix

NASA Astrophysics Data System (ADS)

Stocker, M.; Mokrane, M.; Burton, A.; Koers, H.

2016-12-01

The Scholix framework—Scholarly Link Exchange—is a set of aspirational principles and practical guidelines developed under the umbrella of a joint Working Group of the Research Data Alliance (RDA) and the World Data System (WDS). It supports a global open information ecosystem unveiling the links between scholarly literature and underpinning research data. The core objectives of the framework are to (1) increase visibility and discoverability of data and articles, (2) place data in context to enable re-use, and (3) support credit attribution mechanisms. Thus, facilitating reproducibility and the transparent evaluation of science. Scholix provides an evolving lightweight set of Guidelines to increase interoperability rather than a normative standard. It consists initially of a conceptual and information models, information standards and encoding guidelines, and options for encoding and exchange protocols. An essential prerequisite to enable the proposed framework is the use of global, unique and persistent identifiers for research objects (such as data and literature). Scholix provides incentives and encourages best practice in the use of such identifiers and standardised referencing. The Data and Literature Interlinking Service (DLI: dliservice.research-infrastructures.eu) is the first exemplar of an aggregation and query service supported by the Scholix framework which will allow the emergence of third party services such as domain-specific aggregations, integrations with other global services, discovery tools, impact assessments, etc. Scholix is already implemented by existing hubs or global aggregators of data-literature link information such as DataCite, CrossRef, OpenAIRE, and EMBL-EBI building on the capacities of existing Persistent Identifier Systems (PIDs) such as Digital Object Identifiers (DOI) and Accession Numbers. These hubs in turn work with their natural communities of data centres or literature publishers to collect the information through existing community-specific workflows and standards. Scholix as a technical solution to wholesale information aggregation will need to be complemented by other policy, practice and cultural change advocacy initiatives. This approach could be extended over time to other types of research objects in and beyond research.

ABC Tracker: Increasing Teacher Capacity for Assessing Student Behavior

ERIC Educational Resources Information Center

Borgmeier, Chris; Loman, Sheldon L.; Strickland-Cohen, M. Kathleen

2017-01-01

Students with persistent challenging behavior are present in nearly every classroom. Teachers need the knowledge and skills to understand student behavior and intervene effectively. This article presents a framework to guide teachers in understanding student behavior and feasible tools for collecting data about the function of student behavior.…

Framing Research on School Principals' Identities

ERIC Educational Resources Information Center

Crow, Gary; Day, Christopher; Møller, Jorunn

2017-01-01

This paper provides a basis for a tentative framework for guiding future research into principals' identity construction and development. It is situated in the context of persisting emphases placed by government policies on the need for technocratic competencies in principals as a means of demonstrating success defined largely as compliance with…

Surviving Teacher Education: A Community Cultural Capital Framework of Persistence

ERIC Educational Resources Information Center

Tolbert, Sara; Eichelberger, Serina

2016-01-01

In this article, we communicate the experiences of a bilingual/biracial Peruvian-Anglo European student teacher, Serina, enrolled in a "teacher education for diversity" program. Although the majority of the 13 (mostly Anglo European) students in Serina's cohort expressed satisfaction with the social justice focus of the program, Serina…

Latina/o Dropouts: Generating Community Cultural Wealth

ERIC Educational Resources Information Center

Burciaga, Rebeca; Erbstein, Nancy

2012-01-01

This article builds upon a community cultural wealth framework (Yosso, 2005) to discuss how strategies for school persistence are articulated, cultivated and employed through individual aspirations and practices. The analysis draws from testimonios of six Latina/o young adults between the ages of 18 and 20 living in California's 9-County…

Framework for Application of the Toxicity Equivalence Methodology for Polychlorinated Dioxins, Furans, and Biphenyls in Ecological Risk Assessment (Final)

EPA Science Inventory

Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are persistent contaminants found widely in the environment. Several of these compounds bioaccumulate in the tissues of fish, birds, and mammals and have been shown to cause mortality and adver...

Simulating Global Climate Summits

ERIC Educational Resources Information Center

Vesperman, Dean P.; Haste, Turtle; Alrivy, Stéphane

2014-01-01

One of the most persistent and controversial issues facing the global community is climate change. With the creation of the UN Framework Convention on Climate Change (UNFCCC) in 1992 and the Kyoto Protocol (1997), the global community established some common ground on how to address this issue. However, the last several climate summits have failed…

Motivation and Student Success in Developmental Education

ERIC Educational Resources Information Center

Livingston, Shannon

2017-01-01

Using self-determination theory (Deci & Ryan, 1985) as the theoretical framework, this study explored how high-school GPA and motivation contributed to academic performance and persistence among students enrolled in developmental-education courses during the fall of 2016 at a two-year technical college in the Midwest. A non-random purposive…

"La Familia": The Important Ingredient for Latina/o College Student Engagement and Persistence

ERIC Educational Resources Information Center

Matos, Jennifer M. D.

2015-01-01

This article utilizes Yosso's (2005) community cultural framework and the six forms of cultural capital (aspirational, familial, linguistic, navigational, resistant, social) as corrective reframes of the cultural deficit model. Although the prevailing literature on Latina/o parents and families portray this population as being unmotivated and…

Educational Opportunity: El Salvador's Barriers to Achieving Equality Persist.

ERIC Educational Resources Information Center

Rosekrans, Kristin

This paper analyzes barriers to educational equality in El Salvador, using a multi-layered framework of educational opportunity. To improve educational opportunity and give the most marginalized sectors of society the possibility of changing their life circumstances requires policies that go beyond mere access to formal schooling. The model…

Theoretical Frameworks for Math Fact Fluency

ERIC Educational Resources Information Center

Arnold, Katherine

2012-01-01

Recent education statistics indicate persistent low math scores for our nation's students. This drop in math proficiency includes deficits in basic number sense and automaticity of math facts. The decrease has been recorded across all grade levels with the elementary levels showing the greatest loss (National Center for Education Statistics,…

The Seven Silos of Accountability in Higher Education: Systematizing Multiple Logics and Fields

ERIC Educational Resources Information Center

Brown, Joshua Travis

2017-01-01

Higher education accountability is a field characterized by complexity. Prior frameworks grounded in psychometrics, economics, and history fall short in explaining the persistence and composition of its complexity. This article employs organizational theory to identify the multiple conflicting approaches of higher education accountability and…

Examination of Habitat Fragmentation and Effects on Species Persistence in the Vicinity of Naval Base Pt. Loma and Marine Corps Air Station Miramar, San Diego, CA and Development of a Multi-Species Planning Framework for Fragmented Landscapes

DTIC Science & Technology

2011-02-01

persistence niche. Trends in Ecology & Evolution 16:45-51. 72 Braswell, J. 2007. The effects of el niño and exotic plant invastion on two-way interactions ...Rundel, B. B. Lamont, M. K. Arroyo, and M. Arianoutsou. 1996. Plant diversity in mediterranean-climate regions. Trends in Ecology & Evolution 11:362...Zedler, P. H. 1995. Are some plants born to burn? Trends in Ecology & Evolution 10:393-395. Zedler, P. H., T. Cario, J. Else, and K. Cummins. 1995

archiDART v3.0: A new data analysis pipeline allowing the topological analysis of plant root systems.

PubMed

Delory, Benjamin M; Li, Mao; Topp, Christopher N; Lobet, Guillaume

2018-01-01

Quantifying plant morphology is a very challenging task that requires methods able to capture the geometry and topology of plant organs at various spatial scales. Recently, the use of persistent homology as a mathematical framework to quantify plant morphology has been successfully demonstrated for leaves, shoots, and root systems. In this paper, we present a new data analysis pipeline implemented in the R package archiDART to analyse root system architectures using persistent homology. In addition, we also show that both geometric and topological descriptors are necessary to accurately compare root systems and assess their natural complexity.

archiDART v3.0: A new data analysis pipeline allowing the topological analysis of plant root systems

PubMed Central

Delory, Benjamin M.; Li, Mao; Topp, Christopher N.; Lobet, Guillaume

2018-01-01

Quantifying plant morphology is a very challenging task that requires methods able to capture the geometry and topology of plant organs at various spatial scales. Recently, the use of persistent homology as a mathematical framework to quantify plant morphology has been successfully demonstrated for leaves, shoots, and root systems. In this paper, we present a new data analysis pipeline implemented in the R package archiDART to analyse root system architectures using persistent homology. In addition, we also show that both geometric and topological descriptors are necessary to accurately compare root systems and assess their natural complexity. PMID:29636899

Ontological Problem-Solving Framework for Dynamically Configuring Sensor Systems and Algorithms

PubMed Central

Qualls, Joseph; Russomanno, David J.

2011-01-01

The deployment of ubiquitous sensor systems and algorithms has led to many challenges, such as matching sensor systems to compatible algorithms which are capable of satisfying a task. Compounding the challenges is the lack of the requisite knowledge models needed to discover sensors and algorithms and to subsequently integrate their capabilities to satisfy a specific task. A novel ontological problem-solving framework has been designed to match sensors to compatible algorithms to form synthesized systems, which are capable of satisfying a task and then assigning the synthesized systems to high-level missions. The approach designed for the ontological problem-solving framework has been instantiated in the context of a persistence surveillance prototype environment, which includes profiling sensor systems and algorithms to demonstrate proof-of-concept principles. Even though the problem-solving approach was instantiated with profiling sensor systems and algorithms, the ontological framework may be useful with other heterogeneous sensing-system environments. PMID:22163793

Translating Radiometric Requirements for Satellite Sensors to Match International Standards.

PubMed

Pearlman, Aaron; Datla, Raju; Kacker, Raghu; Cao, Changyong

2014-01-01

International scientific standards organizations created standards on evaluating uncertainty in the early 1990s. Although scientists from many fields use these standards, they are not consistently implemented in the remote sensing community, where traditional error analysis framework persists. For a satellite instrument under development, this can create confusion in showing whether requirements are met. We aim to create a methodology for translating requirements from the error analysis framework to the modern uncertainty approach using the product level requirements of the Advanced Baseline Imager (ABI) that will fly on the Geostationary Operational Environmental Satellite R-Series (GOES-R). In this paper we prescribe a method to combine several measurement performance requirements, written using a traditional error analysis framework, into a single specification using the propagation of uncertainties formula. By using this approach, scientists can communicate requirements in a consistent uncertainty framework leading to uniform interpretation throughout the development and operation of any satellite instrument.

Translating Radiometric Requirements for Satellite Sensors to Match International Standards

PubMed Central

Pearlman, Aaron; Datla, Raju; Kacker, Raghu; Cao, Changyong

2014-01-01

International scientific standards organizations created standards on evaluating uncertainty in the early 1990s. Although scientists from many fields use these standards, they are not consistently implemented in the remote sensing community, where traditional error analysis framework persists. For a satellite instrument under development, this can create confusion in showing whether requirements are met. We aim to create a methodology for translating requirements from the error analysis framework to the modern uncertainty approach using the product level requirements of the Advanced Baseline Imager (ABI) that will fly on the Geostationary Operational Environmental Satellite R-Series (GOES-R). In this paper we prescribe a method to combine several measurement performance requirements, written using a traditional error analysis framework, into a single specification using the propagation of uncertainties formula. By using this approach, scientists can communicate requirements in a consistent uncertainty framework leading to uniform interpretation throughout the development and operation of any satellite instrument. PMID:26601032

The MIXED framework: A novel approach to evaluating mixed-methods rigor.

PubMed

Eckhardt, Ann L; DeVon, Holli A

2017-10-01

Evaluation of rigor in mixed-methods (MM) research is a persistent challenge due to the combination of inconsistent philosophical paradigms, the use of multiple research methods which require different skill sets, and the need to combine research at different points in the research process. Researchers have proposed a variety of ways to thoroughly evaluate MM research, but each method fails to provide a framework that is useful for the consumer of research. In contrast, the MIXED framework is meant to bridge the gap between an academic exercise and practical assessment of a published work. The MIXED framework (methods, inference, expertise, evaluation, and design) borrows from previously published frameworks to create a useful tool for the evaluation of a published study. The MIXED framework uses an experimental eight-item scale that allows for comprehensive integrated assessment of MM rigor in published manuscripts. Mixed methods are becoming increasingly prevalent in nursing and healthcare research requiring researchers and consumers to address issues unique to MM such as evaluation of rigor. © 2017 John Wiley & Sons Ltd.

Data Service: Distributed Data Capture and Replication

NASA Astrophysics Data System (ADS)

Warner, P. B.; Pietrowicz, S. R.

2007-10-01

Data Service is a critical component of the NOAO Data Management and Science Support (DMaSS) Solutions Platform, which is based on a service-oriented architecture, and is to replace the current NOAO Data Transport System. Its responsibilities include capturing data from NOAO and partner telescopes and instruments and replicating the data across multiple (currently six) storage sites. Java 5 was chosen as the implementation language, and Java EE as the underlying enterprise framework. Application metadata persistence is performed using EJB and Hibernate on the JBoss Application Server, with PostgreSQL as the persistence back-end. Although potentially any underlying mass storage system may be used as the Data Service file persistence technology, DTS deployments and Data Service test deployments currently use the Storage Resource Broker from SDSC. This paper presents an overview and high-level design of the Data Service, including aspects of deployment, e.g., for the LSST Data Challenge at the NCSA computing facilities.

Persistent spin helix manipulation by optical doping of a CdTe quantum well

NASA Astrophysics Data System (ADS)

Passmann, F.; Anghel, S.; Tischler, T.; Poshakinskiy, A. V.; Tarasenko, S. A.; Karczewski, G.; Wojtowicz, T.; Bristow, A. D.; Betz, M.

2018-05-01

Time-resolved Kerr-rotation microscopy explores the influence of optical doping on the persistent spin helix in a [001]-grown CdTe quantum well at cryogenic temperatures. Electron spin-diffusion dynamics reveal a momentum-dependent effective magnetic field providing SU(2) spin-rotation symmetry, consistent with kinetic theory. The Dresselhaus and Rashba spin-orbit coupling parameters are extracted independently from rotating the spin helix with external magnetic fields applied parallel and perpendicular to the effective magnetic field. Most importantly, a nonuniform spatiotemporal precession pattern is observed. The kinetic-theory framework of spin diffusion allows for modeling of this finding by incorporating the photocarrier density into the Rashba (α) and the Dresselhaus (β3) parameters. Corresponding calculations are further validated by an excitation-density-dependent measurement. This work shows universality of the persistent spin helix by its observation in a II-VI compound and the ability to fine-tune it by optical doping.

A Psychosociocultural Framework of College Persistence Wellness for Students on Academic Probation

ERIC Educational Resources Information Center

Moore, Leya

2013-01-01

Background: There is increased need for a college educated workforce that is prepared to enter high-demand, technical fields (e.g., science, technology, engineering, math, medicine). Universities continue to be held accountable for improving student retention and degree completion. This study sought to understand the cognitive and noncognitive…

AN OVERVIEW: DECISION-MAKING FRAMEWORK FOR THE ANALYSIS OF ALTERNATIVES FOR THE LONG TERM MANAGEMENT OF MERCURY

EPA Science Inventory

Over the past decade, the Environmental Protection Agency (EPA) has promoted the use of alternatives to mercury because it is a persistent, bio-accumulative, and toxic (PBT) chemical. The Agency's long-term goal for mercury is the elimination of mercury released to the air, wate...

Rural U.S.A.: Persistence and Change.

ERIC Educational Resources Information Center

Ford, Thomas R., Ed.

In 1974 the Rural Sociological Society commissioned a survey on changes that were occuring in different segments of rural society in the United States; information from that survey is presented in the volume of readings. Using an ecological perspective as the analytic framework, the readings focus on the adaption of humans to their environment a…

In Pursuit of Success: Latino Male College Students Exercising Academic Determination and Community Cultural Wealth

ERIC Educational Resources Information Center

Pérez, David, II

2017-01-01

Discourse about Latino male college students centers on their low enrollment, persistence, and graduation rates. Two asset-based theoretical frameworks were used to understand how 21 Latino males' academic determination was nurtured and sustained by cultural wealth at selective institutions. Although most participants entered college with unclear…

Understanding Alternative Education: A Mixed Methods Examination of Student Experiences

ERIC Educational Resources Information Center

Farrelly, Susan Glassett; Daniels, Erika

2014-01-01

Alternative education plays a critical role in the opportunity gap that persists in the US public education system. However, there has been little research on alternative schools. Scaffolded by a theoretical framework constructed from critical theory, self-determination theory (SDT) and student voice, this research examined how well students in…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bush, Brian W; Brunhart-Lupo, Nicholas J; Gruchalla, Kenny M

This brochure describes a system dynamics simulation (SD) framework that supports an end-to-end analysis workflow that is optimized for deployment on ESIF facilities(Peregrine and the Insight Center). It includes (I) parallel and distributed simulation of SD models, (ii) real-time 3D visualization of running simulations, and (iii) comprehensive database-oriented persistence of simulation metadata, inputs, and outputs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bush, Brian W; Brunhart-Lupo, Nicholas J; Gruchalla, Kenny M

This presentation describes a system dynamics simulation (SD) framework that supports an end-to-end analysis workflow that is optimized for deployment on ESIF facilities(Peregrine and the Insight Center). It includes (I) parallel and distributed simulation of SD models, (ii) real-time 3D visualization of running simulations, and (iii) comprehensive database-oriented persistence of simulation metadata, inputs, and outputs.

Summer Freeze: Engaging the Incoming Class to Reduce Admissions Melt

ERIC Educational Resources Information Center

Allen-Stuck, Kimberly M.; McDevitt, Daniel W.

2014-01-01

Persistence to graduation begins with engaging the incoming class even before they have made a deposit. Saint Joseph's University developed a framework for combatting the admissions summer melt following a summer where 20% of the deposits were withdrawn. By employing tactics to monitor student engagement throughout the summer and connecting with…

Development of a Dynamic Energy Budget Modeling Approach to Investigate the Effects of Temperature and Resource Limitation on Mercury Bioaccumulation in Fundulus Heteroclitus

EPA Science Inventory

Dynamic energy budget (DEB) theory provides a generalizable and broadly applicable framework to connect sublethal toxic effects on individuals to changes in population persistence and growth. To explore this approach, we are conducting growth and bioaccumulation studies that cont...

Legacies in material flux: Structural changes before long-term studies

Treesearch

D.J. Bain; M.B. Green; J. Campbell; J. Chamblee; S. Chaoka; J. Fraterrigo; S. Kaushal; S. Martin; T. Jordan; T. Parolari; B. Sobczak; D. Weller; W. M. Wollheim; E. Boose; J. Duncan; G. Gettel; B. Hall; P. Kumar; J. Thompson; J. Vose; E. Elliott; D. Leigh

2012-01-01

Legacy effects of past land use and disturbance are increasingly recognized, yet consistent definitions of and criteria for defining them do not exist. To address this gap in biological- and ecosystem-assessment frameworks, we propose a general metric for evaluating potential legacy effects, which are computed by normalizing altered system function persistence with...

Strategies to Engage Students' Production of Electron Configurations in a Prototypical Chemistry Classroom Community

ERIC Educational Resources Information Center

Grueber, David J.

2012-01-01

This study investigated associations between teacher-student interaction and students' persistence to complete written electron configurations in a high school chemistry classroom. Analyses of the interactions were guided with an Expectancy-Value framework to identify the discourse strategies used by the teacher to build engagement in a classroom…

The Relationship between Object Files and Conscious Perception

ERIC Educational Resources Information Center

Mitroff, S.R.; Scholl, B.J.; Wynn, K.

2005-01-01

Object files (OFs) are hypothesized mid-level representations which mediate our conscious perception of persisting objects-e.g. telling us 'which went where'. Despite the appeal of the OF framework, not previous research has directly explored whether OFs do indeed correspond to conscious percepts. Here we present at least one case wherein…

Post-Formalist Explanation of Academic Achievement: Exploring the Contribution of John Ogbu and Joe Kincheloe

ERIC Educational Resources Information Center

Sinha, Chetan

2016-01-01

The present paper attempts to interrogate the existing approach to understand academic achievement in the mainstream educational psychology. The paper explores the persistent question of "why academic achievement gap" in the modern society from the cultural ecological and postformalist framework of John Ogbu and Joe Kincheloe…

Observing Young Children's Creative Thinking: Engagement, Involvement and Persistence

ERIC Educational Resources Information Center

Robson, Sue; Rowe, Victoria

2012-01-01

This paper looks at young children's creative thinking as inferred through observations of their activities. A total of 52 episodes of child-initiated and adult-initiated activities in 3- to 4-year-olds in an English Children's Centre were analysed using the Analysing Children's Creative Thinking (ACCT) Framework. Results showed that activities…

An obsolete dichotomy? Rethinking the rural–urban interface in terms of food security and production in the global south.

PubMed

Lerner, Amy M; Eakin, Hallie

2011-01-01

The global food system is coming under increasing strain in the face of urban population growth. The recent spike in global food prices (2007–08) provoked consumer protests, and raised questions about food sovereignty and how and where food will be produced. Concurrently, for the first time in history the majority of the global population is urban, with the bulk of urban growth occurring in smaller-tiered cities and urban peripheries, or ‘peri-urban’ areas of the developing world. This paper discusses the new emerging spaces that incorporate a mosaic of urban and rural worlds, and reviews the implications of these spaces for livelihoods and food security. We propose a modified livelihoods framework to evaluate the contexts in which food production persists within broader processes of landscape and livelihood transformation in peri-urban locations. Where and how food production persists are central questions for the future of food security in an urbanising world. Our proposed framework provides directions for future research and highlights the role of policy and planning in reconciling food production with urban growth.

Inner shelf morphologic controls on the dynamics of the beach and bar system, Fire Island, New York

USGS Publications Warehouse

Hapke, Cheryl J.; Schwab, William C.; Gayes, Paul T.; McCoy, Clay; Viso, Richard; Lentz, Erika E.; Rosati, Julie D.; Wang, Ping; Roberts, Tiffany M.

2011-01-01

The mechanism of sediment exchange between offshore sand ridges and the beach at Fire Island, New York is largely unknown. However, recent evidence from repeat nearshore bathymetry surveys, coupled with the complex but consistent bar morphology and patterns of shoreline change demonstrate that there is a feedback occurring between the regional geologic framework and modern processes. Analysis of bathymetric survey data provides direct confirmation that the offshore ridges are connected to the shoreface and are spatially persistent. The fixed nature of the nearshore morphology is further supported by time series camera data that indicate persistent bars with breaks that re-form in the same locations. A long-term time series of shoreline change shows distinct zones of erosion and accretion that are pervasive over time scales greater than a half-century, and their length-scales are similar to the spacing of the offshore ridge-trough system. The first-order geologic framework is responsible for the existence and locations of the ridges and troughs, which then influence the morphodynamics of the beach and bar system.

Computational system identification of continuous-time nonlinear systems using approximate Bayesian computation

NASA Astrophysics Data System (ADS)

Krishnanathan, Kirubhakaran; Anderson, Sean R.; Billings, Stephen A.; Kadirkamanathan, Visakan

2016-11-01

In this paper, we derive a system identification framework for continuous-time nonlinear systems, for the first time using a simulation-focused computational Bayesian approach. Simulation approaches to nonlinear system identification have been shown to outperform regression methods under certain conditions, such as non-persistently exciting inputs and fast-sampling. We use the approximate Bayesian computation (ABC) algorithm to perform simulation-based inference of model parameters. The framework has the following main advantages: (1) parameter distributions are intrinsically generated, giving the user a clear description of uncertainty, (2) the simulation approach avoids the difficult problem of estimating signal derivatives as is common with other continuous-time methods, and (3) as noted above, the simulation approach improves identification under conditions of non-persistently exciting inputs and fast-sampling. Term selection is performed by judging parameter significance using parameter distributions that are intrinsically generated as part of the ABC procedure. The results from a numerical example demonstrate that the method performs well in noisy scenarios, especially in comparison to competing techniques that rely on signal derivative estimation.

Success factors impacting Latina/o persistence in higher education leading to STEM opportunities

NASA Astrophysics Data System (ADS)

Peralta, Claudia; Caspary, Melissa; Boothe, Diane

2013-12-01

This study investigates how Latina/Latino youth resist, conform to, and persist in schooling, and explores their preparation for an education in science, technology, engineering and math (STEM) fields. Using Latino Critical Race Theory as a framework, evidence of the "sticky mess" of racial inequalities (Espinoza and Harris in Calif Law Rev 10:499-559, 1997) and the concept of community cultural wealth (Yosso in Race Ethn Educ 8:69-91, 2005) will be used to understand how Latina/o students successfully persist in college. Quantitative and qualitative findings collected at two public universities in 2007-2012 show that Latina/o parents play a significant role in influencing their children's decision to attend college; family, friend and community support and hard work have also been instrumental in college success. This is evident through parents' encouragement to persist, expectations to do well and students serving as role models for siblings and peers. As policy makers in the educational arena emphasize STEM fields, there is a significant opportunity for Latino students to make valuable contributions.

A human rights framework for midwifery care.

PubMed

Thompson, Joyce Beebe

2004-01-01

This article presents a rights-based model for midwifery care of women and childbearing families. Salient features include discussion of the influence of values on how women are viewed within cultures and societies, universal ethical principles applicable to health care services, and human rights based on the view of women as persons rather than as objects or chattel. Examples of the health impact on women of persistent violation of basic human rights are used to support the need for using a human rights framework for midwifery care--a model supported by codes of ethics, the midwifery philosophy of care, and standards of practice.

The Terri Schiavo case: legal, ethical, and medical perspectives.

PubMed

Perry, Joshua E; Churchill, Larry R; Kirshner, Howard S

2005-11-15

Although tragic, the plight of Terri Schiavo provides a valuable case study. The conflicts and misunderstandings surrounding her situation offer important lessons in medicine, law, and ethics. Despite media saturation and intense public interest, widespread confusion lingers regarding the diagnosis of persistent vegetative state, the judicial processes involved, and the appropriateness of the ethical framework used by those entrusted with Terri Schiavo's care. First, the authors review the current medical understanding of persistent vegetative state, including the requirements for patient examination, the differential diagnosis, and the practice guidelines of the American Academy of Neurology regarding artificial nutrition and hydration for patients with this diagnosis. Second, they examine the legal history, including the 2000 trial, the 2002 evidentiary hearing, and the subsequent appeals. The authors argue that the law did not fail Terri Schiavo, but produced the highest-quality evidence and provided the most judicial review of any end-of-life guardianship case in U.S. history. Third, they review alternative ethical frameworks for understanding the Terri Schiavo case and contend that the principle of respect for autonomy is paramount in this case and in similar cases. Far from being unusual, the manner in which Terri Schiavo's case was reviewed and the basis for the decision reflect a broad medical, legal, and ethical consensus. Greater clarity regarding the persistent vegetative state, less apprehension of the presumed mysteries of legal proceedings, and greater appreciation of the ethical principles at work are the chief benefits obtained from studying this provocative case.

Preferential selection based on strategy persistence and memory promotes cooperation in evolutionary prisoner's dilemma games

NASA Astrophysics Data System (ADS)

Liu, Yuanming; Huang, Changwei; Dai, Qionglin

2018-06-01

Strategy imitation plays a crucial role in evolutionary dynamics when we investigate the spontaneous emergence of cooperation under the framework of evolutionary game theory. Generally, when an individual updates his strategy, he needs to choose a role model whom he will learn from. In previous studies, individuals choose role models randomly from their neighbors. In recent works, researchers have considered that individuals choose role models according to neighbors' attractiveness characterized by the present network topology or historical payoffs. Here, we associate an individual's attractiveness with the strategy persistence, which characterizes how frequently he changes his strategy. We introduce a preferential parameter α to describe the nonlinear correlation between the selection probability and the strategy persistence and the memory length of individuals M into the evolutionary games. We investigate the effects of α and M on cooperation. Our results show that cooperation could be promoted when α > 0 and at the same time M > 1, which corresponds to the situation that individuals are inclined to select their neighbors with relatively higher persistence levels during the evolution. Moreover, we find that the cooperation level could reach the maximum at an optimal memory length when α > 0. Our work sheds light on how to promote cooperation through preferential selection based on strategy persistence and a limited memory length.

Urban Sanctuary Schools for Diverse Populations: Examining Curricular Expectations and School Effectiveness for Student Learning

ERIC Educational Resources Information Center

Liou, Daniel D.; Marsh, Tyson E. J.; Antrop-González, René

2017-01-01

This ethnographic case study problematizes the current high stakes accountability efforts that have led many school leaders to inadvertently maintain a school environment in which deficit perspectives and low academic expectations in the classroom persist. Drawing from an urban sanctuary school framework, this study works to center the voices of…

Latino Student Persistence Strategies in Transferring from Community College to Tier 1 Universities: A Phenomenological Analysis

ERIC Educational Resources Information Center

Harris, Linwood N.

2017-01-01

This study is a departure from discussions on why community college students do not transfer in large numbers, but instead, provides an analysis of Latino students from community college who have successfully transferred to Tier 1 universities. The conceptual framework included student engagement theory (Kuh, 2003), the support for student…

The Native American Persistence in Higher Education: A Journey through Story to Identify the Family Support to Native American Graduates

ERIC Educational Resources Information Center

Bisbee, Yolanda J. Guzman

2013-01-01

This Indigenous Framed Research will utilize counter-storytelling through shared collaborator stories provided by Nez Perce Native American Graduates. The methodology is shaped by an Indigenous Framework as this form of research promotes and develops a culturally resonant environment for constructing, analyzing and sharing information. The…

Government as Anti-Poverty Facilitator in the USA: Static Inequality Gap

ERIC Educational Resources Information Center

Musgrave, Frank W.

2009-01-01

This article explores issues of persistent poverty and income inequality. The major focus is that of the alleviation of poverty. Is there a framework that delineates the roles for government, market forces and self-reliance that can effect a reduction in the level of poverty? The Personal Responsibility and Work Opportunity Reconciliation Act…

Critical Realism and School Effectiveness Research in Colombia: The Difference It Should Make

ERIC Educational Resources Information Center

Parra, Juan David

2018-01-01

This article draws on the case of academic work produced by Colombian scholars, to address the debate on the persistent failure of policy efforts to improve school effectiveness. Realist meta-theory plays a significant role in this research, because it provides a general framework to identify ontological problems and inconsistencies in empirical…

Career Outcomes of STEM and Non-STEM College Graduates: Persistence in Majored-Field and Influential Factors in Career Choices

ERIC Educational Resources Information Center

Xu, Yonghong Jade

2013-01-01

Using data from a nationally representative, longitudinal survey of college graduates, this study examines student transition from college to their chosen career paths and identifies factors influencing college graduates' choosing an occupation related to ones' undergraduate major. Within the context of expanded econometric framework a wide range…

Climate change may restrict dryland forest regeneration in the 21st century

Treesearch

M. D. Petrie; J. B. Bradford; R. M. Hubbard; W. K. Lauenroth; C. M. Andrews; D. R. Schlaepfer

2017-01-01

The persistence and geographic expansion of dryland forests in the 21st century will be influenced by how climate change supports the demographic processes associated with tree regeneration. Yet, the way that climate change may alter regeneration is unclear. We developed a quantitative framework that estimates forest regeneration potential (RP) as a function of key...

Becoming Mathematicians: Women and Students of Color Choosing and Leaving Doctoral Mathematics

ERIC Educational Resources Information Center

Herzig, Abbe H.

2004-01-01

Few women and even fewer African Americans, Latinos, and Native Americans complete doctoral degrees in mathematics in the United States. This article proposes a framework for understanding the small numbers of women and students of color who persist in doctoral mathematics based on the notion that academic and social integration are critical to…

Pavlov's Position on Old Age within the Framework of the Theory of Higher Nervous Activity.

ERIC Educational Resources Information Center

Windholz, George

1995-01-01

In later life, I. P. Pavlov incorporated his findings on aging into his theory of higher nervous activity. Some of the major findings showed that salivary conditioning and stimulus differentiation were difficult to establish in old dogs, but that conditioned reflexes established earlier in life persisted into old age. Pavlov hypothesized that…

Using the Expectancy-Value Theory of Motivation to Predict Behavioral and Emotional Risk among High School Students

ERIC Educational Resources Information Center

Dever, Bridget V.

2016-01-01

Within the expectancy-value framework, much work has been done linking expectancies and task values to academic outcomes such as performance, persistence, and choice. Research on the associations between student motivation (including efficacy and task values) and behavioral and emotional problems, however, is nascent. The present study examined a…

Legacy effects in material flux: structural catchment changes predate long-term studies

Treesearch

Daniel Bain; Mark B. Green; John L. Campbell; John F. Chamblee; Sayo Chaoka; Jennifer M. Fraterrigo; Sujay S. Kaushal; Sujay S. Kaushal; Sherry L. Martin; Thomas E. Jordan; Anthony J. Parolari; William V. Sobczak; Donald E. Weller; Wilfred M. Wolheim; Emery R. Boose; Jonathan M. Duncan; Gretchen M. Gettel; Brian R. Hall; Praveen Kumar; Jonathan R. Thompson; James M. Vose; Emily M. Elliott; David S. Leigh

2012-01-01

Legacy effects of past land use and disturbance are increasingly recognized, yet consistent definitions of and criteria for defining them do not exist. To address this gap in biological- and ecosystem-assessment frameworks, we propose a general metric for evaluating potential legacy effects, which are computed by normalizing altered system function persistence with...

Achieving the Dream: An Examination of Success Factors with a Focus on Cultural Changes

ERIC Educational Resources Information Center

Cornelius, Cathy D.

2013-01-01

This study examines the change process to enhance student persistence and graduation rates in four North Carolina community colleges. Using a qualitative research methodology, Lewin's change model is presented as a framework to investigate the acceptance and implementation of AtD principles in two community colleges. Processes to enhance student…

Using Voicethread to Create Community in Online Learning

ERIC Educational Resources Information Center

Delmas, Peggy M.

2017-01-01

A sense of belonging to a learning community has been identified as one of the factors contributing to greater student satisfaction and persistence in online education programs. Using the community of inquiry framework as a theoretical guide, the purpose of this study was to explore the role of VoiceThread, a web-based platform that facilitates…

Fractured Memories, Mended Lives: The Schooling Experiences of Latinas/os in Rural Areas

ERIC Educational Resources Information Center

Peralta, Claudia

2013-01-01

This study explored how Mexican immigrant and first-generation Mexican youth resist, conform to, and persist in schooling. Using Latino Critical Race Theory (LatCrit) as a framework, evidence of the "sticky mess" of racial inequalities (Espinoza & Harris, 1997) was shown to impact the lives of all participants. However, the strength…

Integrating Theory and Practice to Increase Scientific Workforce Diversity: A Framework for Career Development in Graduate Research Training

ERIC Educational Resources Information Center

Byars-Winston, Angela; Gutierrez, Belinda; Topp, Sharon; Carnes, Molly

2011-01-01

Few, if any, educational interventions intended to increase underrepresented minority (URM) graduate students in biological and behavioral sciences are informed by theory and research on career persistence. Training and Education to Advance Minority Scholars in Science (TEAM-Science) is a program funded by the National Institute of General Medical…

Exploring Sense of Community and Persistence in the Community College

ERIC Educational Resources Information Center

Bengfort, Randall R.

2012-01-01

As concern grows about the level of college completion in the U.S., higher education leaders are seeking ways to help more students attain their educational objectives. This study sought to aid that effort by determining if a theoretical framework of sense of community developed by McMillan and Chavis (1986) influences students' decisions to…

A Framework for Interaction and Cognitive Engagement in Connectivist Learning Contexts

ERIC Educational Resources Information Center

Wang, Zhijun; Chen, Li; Anderson, Terry

2014-01-01

Interaction has always been highly valued in education, especially in distance education (Moore, 1989; Anderson, 2003; Chen, 2004a; Woo & Reeves, 2007; Wang, 2013; Conrad, in press). It has been associated with motivation (Mahle, 2011; Wen-chi, et al., 2011), persistence (Tello, 2007; Joo, Lim, & Kim, 2011), deep learning (Offir, et al.,…

Beyond Academics: A Holistic Framework for Enhancing Education and Workplace Success. ACT Research Report Series. 2015 (4)

ERIC Educational Resources Information Center

Camara, Wayne, Ed.; O'Connor, Ryan, Ed.; Mattern, Krista, Ed.; Hanson, Mary Ann, Ed.

2015-01-01

Colleges have long recognized the importance of multiple domains. Admissions officers look to high school grades as indicators of persistence and achievement; student statements and letters of recommendation as indicators of character, behavior, and adaptability; the rigor of courses completed in high school as evidence of effort, motivation, and…

Environmental Persistence Influences Infection Dynamics for a Butterfly Pathogen

PubMed Central

Altizer, Sonia; Williams, Mary-Kate; Hall, Richard J.

2017-01-01

Many pathogens, including those infecting insects, are transmitted via dormant stages shed into the environment, where they must persist until encountering a susceptible host. Understanding how abiotic conditions influence environmental persistence and how these factors influence pathogen spread are crucial for predicting patterns of infection risk. Here, we explored the consequences of environmental transmission for infection dynamics of a debilitating protozoan parasite (Ophryocystis elektroscirrha) that infects monarch butterflies (Danaus plexippus). We first conducted an experiment to observe the persistence of protozoan spores exposed to natural conditions. Experimental results showed that, contrary to our expectations, pathogen doses maintained high infectivity even after 16 days in the environment, although pathogens did yield infections with lower parasite loads after environmental exposure. Because pathogen longevity exceeded the time span of our experiment, we developed a mechanistic model to better explore environmental persistence for this host-pathogen system. Model analysis showed that, in general, longer spore persistence led to higher infection prevalence and slightly smaller monarch population sizes. The model indicated that typical parasite doses shed onto milkweed plants must remain viable for a minimum of 3 weeks for prevalence to increase during the summer-breeding season, and for 11 weeks or longer to match levels of infection commonly reported from the wild, assuming moderate values for parasite shedding rate. Our findings showed that transmission stages of this butterfly pathogen are long-lived and indicated that this is a necessary condition for the protozoan to persist in local monarch populations. This study provides a modeling framework for future work examining the dynamics of an ecologically important pathogen in an iconic insect. PMID:28099501

What do we mean by "older adults' persistent pain self-management"? A concept analysis.

PubMed

Stewart, Carrie; Schofield, Pat; Elliott, Alison M; Torrance, Nicola; Leveille, Suzanne

2014-02-01

No standard definition exists for the concept "persistent pain self-management" or how it should be defined in relation to older adults. Poorly defined concepts can result in misunderstandings in the clinical setting and can hinder research through difficulties identifying or measuring the concept. To ascertain attributes, referents, antecedents, and consequences of the concept older adults' persistent pain self-management and develop a theoretical definition. Rodgers evolutionary model of concept analysis was used to systematically analyze articles from the academic and grey literature (N = 45). Data were extracted using standardized extraction forms and analyzed using thematic analysis. This concept was discussed in three ways: as an intervention, in reference to everyday behaviors, and as an outcome. Five defining attributes were identified: multidimensional process, personal development, active individuals, symptom response, and symptom control. Patients' perceived need and ability to manage pain with support from others is necessary for pain self-management to occur. Numerous physical, psychological, and social health consequences were identified. A theoretical definition is discussed. Our findings have clarified existing use and understanding regarding the concept of older adults' persistent pain self-management. We have identified three areas for future development: refinement of the attributes of this concept within the context of older adults, an exploration of how providers can overcome difficulties supporting older adults' persistent pain self-management, and a clarification of the overall theoretical framework of older adults' persistent pain self-management. Wiley Periodicals, Inc.

Reducing Oral Health Disparities: A Focus on Social and Cultural Determinants

PubMed Central

Patrick, Donald L; Lee, Rosanna Shuk Yin; Nucci, Michele; Grembowski, David; Jolles, Carol Zane; Milgrom, Peter

2006-01-01

Oral health is essential to the general health and well-being of individuals and the population. Yet significant oral health disparities persist in the U.S. population because of a web of influences that include complex cultural and social processes that affect both oral health and access to effective dental health care. This paper introduces an organizing framework for addressing oral health disparities. We present and discuss how the multiple influences on oral health and oral health disparities operate using this framework. Interventions targeted at different causal pathways bring new directions and implications for research and policy in reducing oral health disparities. PMID:16934121

Ontological Problem-Solving Framework for Assigning Sensor Systems and Algorithms to High-Level Missions

PubMed Central

Qualls, Joseph; Russomanno, David J.

2011-01-01

The lack of knowledge models to represent sensor systems, algorithms, and missions makes opportunistically discovering a synthesis of systems and algorithms that can satisfy high-level mission specifications impractical. A novel ontological problem-solving framework has been designed that leverages knowledge models describing sensors, algorithms, and high-level missions to facilitate automated inference of assigning systems to subtasks that may satisfy a given mission specification. To demonstrate the efficacy of the ontological problem-solving architecture, a family of persistence surveillance sensor systems and algorithms has been instantiated in a prototype environment to demonstrate the assignment of systems to subtasks of high-level missions. PMID:22164081

Interaction Between Ecohydrologic Dynamics and Microtopographic Variability Under Climate Change

NASA Astrophysics Data System (ADS)

Le, Phong V. V.; Kumar, Praveen

2017-10-01

Vegetation acclimation resulting from elevated atmospheric CO2 concentration, along with response to increased temperature and altered rainfall pattern, is expected to result in emergent behavior in ecologic and hydrologic functions. We hypothesize that microtopographic variability, which are landscape features typically of the length scale of the order of meters, such as topographic depressions, will play an important role in determining this dynamics by altering the persistence and variability of moisture. To investigate these emergent ecohydrologic dynamics, we develop a modeling framework, Dhara, which explicitly incorporates the control of microtopographic variability on vegetation, moisture, and energy dynamics. The intensive computational demand from such a modeling framework that allows coupling of multilayer modeling of the soil-vegetation continuum with 3-D surface-subsurface flow processes is addressed using hybrid CPU-GPU parallel computing framework. The study is performed for different climate change scenarios for an intensively managed agricultural landscape in central Illinois, USA, which is dominated by row-crop agriculture, primarily soybean (Glycine max) and maize (Zea mays). We show that rising CO2 concentration will decrease evapotranspiration, thus increasing soil moisture and surface water ponding in topographic depressions. However, increased atmospheric demand from higher air temperature overcomes this conservative behavior resulting in a net increase of evapotranspiration, leading to reduction in both soil moisture storage and persistence of ponding. These results shed light on the linkage between vegetation acclimation under climate change and microtopography variability controls on ecohydrologic processes.

Using Bayesian Population Viability Analysis to Define Relevant Conservation Objectives.

PubMed

Green, Adam W; Bailey, Larissa L

2015-01-01

Adaptive management provides a useful framework for managing natural resources in the face of uncertainty. An important component of adaptive management is identifying clear, measurable conservation objectives that reflect the desired outcomes of stakeholders. A common objective is to have a sustainable population, or metapopulation, but it can be difficult to quantify a threshold above which such a population is likely to persist. We performed a Bayesian metapopulation viability analysis (BMPVA) using a dynamic occupancy model to quantify the characteristics of two wood frog (Lithobates sylvatica) metapopulations resulting in sustainable populations, and we demonstrate how the results could be used to define meaningful objectives that serve as the basis of adaptive management. We explored scenarios involving metapopulations with different numbers of patches (pools) using estimates of breeding occurrence and successful metamorphosis from two study areas to estimate the probability of quasi-extinction and calculate the proportion of vernal pools producing metamorphs. Our results suggest that ≥50 pools are required to ensure long-term persistence with approximately 16% of pools producing metamorphs in stable metapopulations. We demonstrate one way to incorporate the BMPVA results into a utility function that balances the trade-offs between ecological and financial objectives, which can be used in an adaptive management framework to make optimal, transparent decisions. Our approach provides a framework for using a standard method (i.e., PVA) and available information to inform a formal decision process to determine optimal and timely management policies.

The CREAM-CE: First experiences, results and requirements of the four LHC experiments

NASA Astrophysics Data System (ADS)

Mendez Lorenzo, Patricia; Santinelli, Roberto; Sciaba, Andrea; Thackray, Nick; Shiers, Jamie; Renshall, Harry; Sgaravatto, Massimo; Padhi, Sanjay

2010-04-01

In terms of the gLite middleware, the current LCG-CE used by the four LHC experiments is about to be deprecated. The new CREAM-CE service (Computing Resource Execution And Management) has been approved to replace the previous service. CREAM-CE is a lightweight service created to handle job management operations at the CE level. It is able to accept requests both via the gLite WMS service and also via direct submission for transmission to the local batch system. This flexible duality provides the experiments with a large level of freedom to adapt the service to their own computing models, but at the same time it requires a careful follow up of the requirements and tests of the experiments to ensure that their needs are fulfilled before real data taking. In this paper we present the current testing results of the four LHC experiments concerning this new service. The operations procedures, which have been elaborated together with the experiment support teams will be discussed. Finally, the experiments requirements and the expectations for both the sites and the service itself are exposed in detail.

Short-Term Global Horizontal Irradiance Forecasting Based on Sky Imaging and Pattern Recognition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, Brian S; Feng, Cong; Cui, Mingjian

Accurate short-term forecasting is crucial for solar integration in the power grid. In this paper, a classification forecasting framework based on pattern recognition is developed for 1-hour-ahead global horizontal irradiance (GHI) forecasting. Three sets of models in the forecasting framework are trained by the data partitioned from the preprocessing analysis. The first two sets of models forecast GHI for the first four daylight hours of each day. Then the GHI values in the remaining hours are forecasted by an optimal machine learning model determined based on a weather pattern classification model in the third model set. The weather pattern ismore » determined by a support vector machine (SVM) classifier. The developed framework is validated by the GHI and sky imaging data from the National Renewable Energy Laboratory (NREL). Results show that the developed short-term forecasting framework outperforms the persistence benchmark by 16% in terms of the normalized mean absolute error and 25% in terms of the normalized root mean square error.« less

Managing Climate Change Refugia for Climate Adaptation ...

EPA Pesticide Factsheets

The concept of refugia has long been studied from theoretical and paleontological perspectives to understand how populations persisted during past periods of unfavorable climate. Recently, researchers have applied the idea to contemporary landscapes to identify climate change refugia, locations that may be unusually buffered from climate change effects so as to increase persistence of valued resources. Here we distinguish between paleoecological and contemporary viewpoints, characterize physical and ecological processes that create and maintain climate change refugia, summarize the process of identifying and mapping them, and delineate how refugia can fit into the existing framework of natural resource management. We also suggest three primary courses of action at these sites: prioritization, protection, and propagation. Although not a panacea, managing climate change refugia can be an important adaptation option for conserving valuable resources in the face of ongoing and future climate change. “In a nutshell” (100 words) • Climate change refugia are defined as areas relatively buffered from contemporary climate change, enabling persistence of valued physical, ecological, and cultural resources. • Refugia can be incorporated as key components of a climate adaptation strategy because their prioritization by management may enable their associated resources to persist locally and eventually spread to future suitable habitat. • Steps for

Beyond Turnaround: A Synthesis of Relevant Frameworks for Leaders of Sustained Improvement in Previously Low-Performing Schools

ERIC Educational Resources Information Center

Hitt, Dallas Hambrick; Meyers, Coby V.

2018-01-01

We understand very little about what is special that leaders do to facilitate improvement that is both transformational and lasting in previously persistently failing schools in the United States. Relatively little is understood about change not just during the initial turnaround stage, but that "endures" on the larger journey as the…

An Instructional Model to Support Problem-Based Historical Inquiry: The Persistent Issues in History Network

ERIC Educational Resources Information Center

Brush, Thomas; Saye, John

2014-01-01

For over a decade, we have collaborated with secondary school history teachers in an evolving line of inquiry that applies research-based propositions to the design and testing of a problem-based learning framework and a set of wise practices that represent a professional teaching knowledge base for implementing a particular model of instruction,…

Innovation and Persistence: The Evaluation of the C.U.P.L.E. Studio Physics Course.

ERIC Educational Resources Information Center

Cooper, Marie A.; O'Donnell, Angela M.

The last decade has seen the development of a number of computer-based interactive physics programs at the university level. Set in a cognitive apprenticeship framework, such programs view the instructor as a mentor, and the essential learning constructed in a collaborative process. It is expected that such programs, grounded as they are in…

Women's and Men's Choice of Higher Education--What Explains the Persistent Sex Segregation in Norway?

ERIC Educational Resources Information Center

Storen, Liv Anne; Arnesen, Clara Ase

2007-01-01

This article examines sex segregation in higher education in Norway. The extent to which parent's education and occupation and students' grades have an impact on the choice of male and female dominated subjects is analysed. The analysis uses a framework which integrates socialisation and rational choice perspectives. The data used are from a…

Up or Down and Out? A Systemic Analysis of Young People's Educational Pathways in the Youth Justice System in England and Wales

ERIC Educational Resources Information Center

Lanskey, Caroline

2015-01-01

Many young people in the youth justice system in England and Wales are educationally marginalised and systemic barriers to their engagement with education persist. This article presents an analytical framework for understanding how education and youth justice practices shape young people's educational pathways during their time in the youth…

An Exploratory Phenomenological Study of African American Male Pre-Service Teachers at a Historical Black University in the Mid-South

ERIC Educational Resources Information Center

Yates, Lucian, III; Pelphrey, Barry A.; Smith, Patricia A.

2008-01-01

This exploratory phenomenological study was conducted to ascertain which factors caused African American male pre-service teachers to persist at a HBCU [Historically Black Colleges and Universities] in the Mid-South. The work is grounded in the conceptual framework called resiliency. Resiliency asks the question, "How do children,…

Beyond College Eligibility: A New Framework for Promoting College Readiness. College Readiness Indicator Systems Resource Series

ERIC Educational Resources Information Center

Annenberg Institute for School Reform at Brown University, 2014

2014-01-01

The College Readiness Indicator Systems (CRIS) initiative was developed in response to a troubling pattern: More students than ever are enrolling in college after high school, but many of them are not college ready, as evidenced by persistently low rates of college completion. The sense of urgency to close the gap between college eligibility and…

Social amplification of wildfire risk: The role of social interactions and information sources

Treesearch

Hannah Brenkert-Smith; Katherine L. Dickinson; Patricia A. Champ; Nicholas Flores

2013-01-01

Wildfire is a persistent and growing threat across much of the western United States. Understanding how people living in fire-prone areas perceive this threat is essential to the design of effective risk management policies. Drawing on the social amplification of risk framework, we develop a conceptual model of wildfire risk perceptions that incorporates the social...

The Role of Academic Student Services in the Retention of American Indian Students at a Sub-Baccalaureate Technical College

ERIC Educational Resources Information Center

Schmidtke, Carsten

2016-01-01

Perceptions of graduating American Indian students at a mainstream sub-baccalaureate technical college about how support from academic student services had helped them learn and persist in their studies were solicited. Bean's (2005) themes of college student retention served as the framework for the inquiry. Findings indicate that (1) academic…

A Holistic Conception of Nonacademic Support: How Four Mechanisms Combine to Encourage Positive Student Outcomes in the Community College

ERIC Educational Resources Information Center

Mechur Karp, Melinda

2016-01-01

Despite their best efforts, community colleges continue to see low rates of student persistence and degree attainment. Although such outcomes can be attributed in large part to students' lack of academic readiness, nonacademic issues also play a part. Building on Karp's 2011 framework of nonacademic support, this chapter explores the evidence that…

A Narrative Engagement Framework to Understand HPV Vaccination among Latina and Vietnamese Women in a Planned Parenthood Setting

ERIC Educational Resources Information Center

Hopfer, Suellen; Garcia, Samantha; Duong, Huong T.; Russo, Jennefer A.; Tanjasiri, Sora P.

2017-01-01

Disparities in cervical cancer and human papillomavirus (HPV) vaccination persist among Vietnamese and Latina women. Through a partnership with Planned Parenthood of Orange and San Bernardino Counties (PPOSBC) in Southern California, we conducted in-depth interviews with young adult Latina (n = 24) and Vietnamese (n = 24) women, and PPOSBC staff…

Can Schools Reduce Bullying? The Relationship between School Characteristics and the Prevalence of Bullying Behaviours

ERIC Educational Resources Information Center

Muijs, Daniel

2017-01-01

Background: Bullying remains a persistent phenomenon in schools, but the extent to which day-to-day policies and practices relate to bullying prevalence has not been widely studied. In this study, we use an educational effectiveness framework to interrogate this relationship. Aims: The aim was to study the relationship between school factors and…

The Problem of Late ART initiation in Sub-Saharan Africa: A Transient Aspect of Scale-up or a Long-term Phenomenon?

PubMed Central

Lahuerta, Maria; Ue, Frances; Hoffman, Susie; Elul, Batya; Kulkarni, Sarah Gorrell; Wu, Yingfeng; Nuwagaba-Biribonwoha, Harriet; Remien, Robert H.; Sadr, Wafaa El; Nash, Denis

2013-01-01

Efforts to scale-up HIV care and treatment have been successful at initiating large numbers of patients onto antiretroviral therapy (ART), although persistent challenges remain to optimizing scale-up effectiveness in both resource-rich and resource-limited settings. Among the most important are very high rates of ART initiation in the advanced stages of HIV disease, which in turn drive morbidity, mortality, and onward transmission of HIV. With a focus on sub-Saharan Africa, this review article presents a conceptual framework for a broader discussion of the persistent problem of late ART initiation, including a need for more focus on the upstream precursors (late HIV diagnosis and late enrollment into HIV care) and their determinants. Without additional research and identification of multilevel interventions that successfully promote earlier initiation of ART, the problem of late ART initiation will persist, significantly undermining the long-term impact of HIV care scale-up on reducing mortality and controlling the HIV epidemic. PMID:23377739

‘Activity-silent’ working memory in prefrontal cortex: a dynamic coding framework

PubMed Central

Stokes, Mark G.

2015-01-01

Working memory (WM) provides the functional backbone to high-level cognition. Maintenance in WM is often assumed to depend on the stationary persistence of neural activity patterns that represent memory content. However, accumulating evidence suggests that persistent delay activity does not always accompany WM maintenance but instead seems to wax and wane as a function of the current task relevance of memoranda. Furthermore, new methods for measuring and analysing population-level patterns show that activity states are highly dynamic. At first glance, these dynamics seem at odds with the very nature of WM. How can we keep a stable thought in mind while brain activity is constantly changing? This review considers how neural dynamics might be functionally important for WM maintenance. PMID:26051384

ADVANCED WORKER PROTECTION SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judson Hedgehock

2001-03-16

From 1993 to 2000, OSS worked under a cost share contract from the Department of Energy (DOE) to develop an Advanced Worker Protection System (AWPS). The AWPS is a protective ensemble that provides the user with both breathing air and cooling for a NIOSH-rated duration of two hours. The ensemble consists of a liquid air based backpack, a Liquid Cooling Garment (LCG), and an outer protective garment. The AWPS project was divided into two phases. During Phase 1, OSS developed and tested a full-scale prototype AWPS. The testing showed that workers using the AWPS could work twice as long asmore » workers using a standard SCBA. The testing also provided performance data on the AWPS in different environments that was used during Phase 2 to optimize the design. During Phase 1, OSS also performed a life-cycle cost analysis on a representative clean up effort. The analysis indicated that the AWPS could save the DOE millions of dollars on D and D activities and improve the health and safety of their workers. During Phase 2, OSS worked to optimize the AWPS design to increase system reliability, to improve system performance and comfort, and to reduce the backpack weight and manufacturing costs. To support this design effort, OSS developed and tested several different generations of prototype units. Two separate successful evaluations of the ensemble were performed by the International Union of Operation Engineers (IUOE). The results of these evaluations were used to drive the design. During Phase 2, OSS also pursued certifying the AWPS with the applicable government agencies. The initial intent during Phase 2 was to finalize the design and then to certify the system. OSS and Scott Health and Safety Products teamed to optimize the AWPS design and then certify the system with the National Institute of Occupational Health and Safety (NIOSH). Unfortunately, technical and programmatic difficulties prevented us from obtaining NIOSH certification. Despite the inability of NIOSH to certify the design, OSS was able to develop and successfully test, in both the lab and in the field, a prototype AWPS. They clearly demonstrated that a system which provides cooling can significantly increase worker productivity by extending the time they can function in a protective garment. They were also able to develop mature outer garment and LCG designs that provide considerable benefits over current protective equipment, such as self donning and doffing, better visibility, and machine washable. A thorough discussion of the activities performed during Phase 1 and Phase 2 is presented in the AWPS Final Report. The report also describes the current system design, outlines the steps needed to certify the AWPS, discusses the technical and programmatic issues that prevented the system from being certified, and presents conclusions and recommendations based upon the seven year effort.« less

Interactions between social structure, demography, and transmission determine disease persistence in primates.

PubMed

Ryan, Sadie J; Jones, James H; Dobson, Andrew P

2013-01-01

Catastrophic declines in African great ape populations due to disease outbreaks have been reported in recent years, yet we rarely hear of similar disease impacts for the more solitary Asian great apes, or for smaller primates. We used an age-structured model of different primate social systems to illustrate that interactions between social structure and demography create 'dynamic constraints' on the pathogens that can establish and persist in primate host species with different social systems. We showed that this varies by disease transmission mode. Sexually transmitted infections (STIs) require high rates of transmissibility to persist within a primate population. In particular, for a unimale social system, STIs require extremely high rates of transmissibility for persistence, and remain at extremely low prevalence in small primates, but this is less constrained in longer-lived, larger-bodied primates. In contrast, aerosol transmitted infections (ATIs) spread and persist at high prevalence in medium and large primates with moderate transmissibility;, establishment and persistence in small-bodied primates require higher relative rates of transmissibility. Intragroup contact structure - the social network - creates different constraints for different transmission modes, and our model underscores the importance of intragroup contacts on infection prior to intergroup movement in a structured population. When alpha males dominate sexual encounters, the resulting disease transmission dynamics differ from when social interactions are dominated by mother-infant grooming events, for example. This has important repercussions for pathogen spread across populations. Our framework reveals essential social and demographic characteristics of primates that predispose them to different disease risks that will be important for disease management and conservation planning for protected primate populations.

A conceptual framework for the evolutionary origins of multicellularity

NASA Astrophysics Data System (ADS)

Libby, Eric; Rainey, Paul B.

2013-06-01

The evolution of multicellular organisms from unicellular counterparts involved a transition in Darwinian individuality from single cells to groups. A particular challenge is to understand the nature of the earliest groups, the causes of their evolution, and the opportunities for emergence of Darwinian properties. Here we outline a conceptual framework based on a logical set of possible pathways for evolution of the simplest self-replicating groups. Central to these pathways is the recognition of a finite number of routes by which genetic information can be transmitted between individual cells and groups. We describe the form and organization of each primordial group state and consider factors affecting persistence and evolution of the nascent multicellular forms. Implications arising from our conceptual framework become apparent when attempting to partition fitness effects at individual and group levels. These are discussed with reference to the evolutionary emergence of individuality and its manifestation in extant multicellular life—including those of marginal Darwinian status.

Extended inheritance from an organizational point of view.

PubMed

Pontarotti, Gaëlle

2015-12-01

In this paper, I argue that the increasing data about non-genetic inheritance requires the construction of a new conceptual framework that should complement the inclusive approaches already discussed in the literature. More precisely, I hold that this framework should be epistemologically relevant for evolutionary biologists in capturing the limits of extended inheritance and in reassessing the boundaries of biological systems that transmit traits to their offspring. I outline the first elements of an organizational account of extended inheritance. In this account, the category of inherited factors is neither restricted to genes nor extended to stable resources related to trans-generational similarities. Instead, it includes persisting constitutive elements appearing as difference makers for heterogeneous organizational constraints, namely for heterogeneous constitutive parts whose specific role is to harness flows of matter and energy across generations of clearly delimited extended organized systems. This both inclusive and restrictive framework opens an additional way to apprehend how extended inheritance may affect evolutionary trajectories.

Assembling evidence for identifying reservoirs of infection

PubMed Central

Viana, Mafalda; Mancy, Rebecca; Biek, Roman; Cleaveland, Sarah; Cross, Paul C.; Lloyd-Smith, James O.; Haydon, Daniel T.

2014-01-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. PMID:24726345

Assembling evidence for identifying reservoirs of infection

USGS Publications Warehouse

Mafalda, Viana; Rebecca, Mancy; Roman, Biek; Sarah, Cleaveland; Cross, Paul C.; James O, Lloyd-Smith; Daniel T, Haydon

2014-01-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems.

Unified Behavior Framework for Reactive Robot Control in Real-Time Systems

DTIC Science & Technology

2007-03-01

maintain coherent operation in concurrent programs by employing standard communication and synchronization patterns. Some typical ones are: semaphores ...through the semaphore . Signals, whether persistent or transient, are used to communicate between threads as a means of synchronizing their progress...tasks to be decomposed into collections of low-level primitive behaviors, Figure 2.b. This approach takes on the self- contradictory term, reactive

Critical Thinking & Lifelong Learning: An ADKAR Model-Based Framework for Managing a Change in Thinking & English Language Learning Styles at the Secondary Stage

ERIC Educational Resources Information Center

Abdallah, Mahmoud M. S.; Mohammad, Marwa M. M.

2016-01-01

The general secondary stage in Egypt is a vital educational phase since it plays an essential role in developing students' thinking and learning styles to prepare them for life in general and higher education in particular. Accordingly, it has become urgent and persistent to develop secondary-stage students' critical thinking styles while…

Formational Turning Points in the Transition to College: Understanding How Communication Events Shape First-Generation Students' Pedagogical and Interpersonal Relationships with Their College Teachers

ERIC Educational Resources Information Center

Wang, Tiffany R.

2014-01-01

In the present study, I explored student-teacher interaction, student-teacher relationship formation and development, and the ways in which student-teacher interaction and relationships facilitated support and persistence for first-generation (FG) students during the transition to college. Using transition theory as a sensitizing framework, I took…

Paleoenvironmental framework for understanding the development, stability, and state-changes of cienegas in the American deserts

Treesearch

Thomas A. Minckley; Andrea Brunelle; Dale Turner

2013-01-01

As persistent wetlands in arid regions, ciénegas represent important resources for the maintenance and preservation of regional biodiversity. The history of ciénegas in the American Southwest over the last 8,000 years provides information on the dynamics of growth, longevity, and stability of these habitats under previous climate conditions. Proxy data such as...

The Retention of Women in Science, Technology, Engineering, and Mathematics: A Framework for Persistence

ERIC Educational Resources Information Center

White, Jeffry L.; Massiha, G. H.

2016-01-01

Women make up 47% of the total U.S. workforce, but are less represented in engineering, computer sciences, and the physical sciences. In addition, race and ethnicity are salient factors and minority women comprise fewer than 1 in 10 scientist or engineer. In this paper, a review of the literature is under taken that explores the many challenges…

Characteristics Associated with Persistence and Retention among First-Generation College Students Majoring in Science, Technology, Engineering, or Math

NASA Astrophysics Data System (ADS)

Burnett, Lorie Lasseter

Persistence and retention of college students is a great concern in American higher education. The dropout rate is even more apparent among first-generation college students, as well as those majoring in science, technology, engineering, and math (STEM). More students earning STEM degrees are needed to fill the many jobs that require the skills obtained while in college. More importantly, those students who are associated with a low-socioeconomic background may use a degree to overcome poverty. Although many studies have been conducted to determine the characteristics associated with student attrition among first-generation students or STEM majors, very little information exists in terms of persistence and retention among the combined groups. The current qualitative study identified some of the characteristics associated with persistence and retention among first-generation college students who are also STEM majors. Participants were juniors or seniors enrolled at a regional 4-year institution. Face-to-face interviews were conducted to allow participants to share their personal experiences as first-generation STEM majors who continue to persist and be retained by their institution. Tinto's Theory of Individual Departure (1987) was used as a framework for the investigation. This theory emphasizes personal and academic background, personal goals, disconnecting from one's own culture, and institutional integration as predictors of persistence. The findings of the investigation revealed that persisting first-generation STEM majors are often connected to family, but have been able to separate that connection with that of the institution. They also are goal-driven and highly motivated and have had varied pre-college academic experiences. These students are academically integrated and socially integrated in some ways, but less than their non-first-generation counterparts. They are overcoming obstacles that students from other backgrounds may not experience. They receive support from their families and institution, but have diverse academic backgrounds. The findings show that a culmination of many characteristics have enabled the participants to persist and be retained by their institution.

Persistence of undergraduate women in STEM fields

NASA Astrophysics Data System (ADS)

Pedone, Maggie Helene

The underrepresentation of women in science, technology, engineering, and mathematics (STEM) is a complex problem that continues to persist at the postsecondary level, particularly in computer science and engineering fields. This dissertation explored the pre-college and college level factors that influenced undergraduate women's persistence in STEM. This study also examined and compared the characteristics of undergraduate women who entered STEM fields and non-STEM fields in 2003-2004. The nationally representative Beginning Postsecondary Students Longitudinal Study (BPS:04/09) data set was used for analysis. BPS:04/09 study respondents were surveyed three times (NPSAS:04, BPS:04/06, BPS:04/09) over a six-year period, which enabled me to explore factors related to long-term persistence. Astin's Input-Environment-Output (I-E-O) model was used as the framework to examine student inputs and college environmental factors that predict female student persistence (output) in STEM. Chi-square tests revealed significant differences between undergraduate women who entered STEM and non-STEM fields in 2003-2004. Differences in student demographics, prior academic achievement, high school course-taking patterns, and student involvement in college such as participation in study groups and school clubs were found. Notably, inferential statistics showed that a significantly higher proportion of female minority students entered STEM fields than non-STEM fields. These findings challenge the myth that underrepresented female minorities are less inclined to enter STEM fields. Logistic regression analyses revealed thirteen significant predictors of persistence for undergraduate women in STEM. Findings showed that undergraduate women who were younger, more academically prepared, and academically and socially involved in college (e.g., lived on campus, interacted with faculty, participated in study groups, fine arts activities, and school sports) were more likely to persist in STEM fields. This longitudinal study showed that both pre-college and college level factors influenced undergraduate women's persistence in STEM. The research findings offer important implications for policy and practice initiatives in higher education that focus on the recruitment and retention of women in postsecondary STEM fields.

What Motivates Biology Instructors to Engage and Persist in Teaching Professional Development?

PubMed Central

McCourt, Jill S.; Andrews, Tessa C.; Knight, Jennifer K.; Merrill, John E.; Nehm, Ross H.; Pelletreau, Karen N.; Prevost, Luanna B.; Smith, Michelle K.; Urban-Lurain, Mark; Lemons, Paula P.

2017-01-01

We conducted a study of 19 biology instructors participating in small, local groups at six research-intensive universities connected to the Automated Analysis of Constructed Response (AACR) project (www.msu.edu/∼aacr). Our aim was to uncover participants’ motivation to persist in a long-term teaching professional development effort, a topic that is understudied in discipline-based educational research. We interviewed each participant twice over a 2-year period and conducted qualitative analyses on the data, using expectancy-value theory as a framework for considering motivation. Our analyses revealed that motivation among instructors was high due to their enjoyment of the AACR groups. The high level of motivation is further explained by the fact that AACR groups facilitated instructor involvement with the larger AACR project. We also found that group dynamics encouraged persistence; instructors thought they might never talk with colleagues about teaching in the absence of AACR groups; and groups were perceived to have a low-enough time requirement to warrant sustained involvement. We conclude that instructors have persisted in AACR groups because the groups provided great value with limited cost. The characterization of instructor experiences described here can contribute to a better understanding of faculty needs in teaching professional development. PMID:28821539

Effects of response preference on resistance to change.

PubMed

Ringdahl, Joel E; Berg, Wendy K; Wacker, David P; Crook, Kayla; Molony, Maggie A; Vargo, Kristina K; Neurnberger, Jodi E; Zabala, Karla; Taylor, Christopher J

2018-01-01

Treatments based on differential reinforcement of alternative behavior, such as functional communication training, are widely used. Research regarding the maintenance of related treatment effects is limited. Nevin and Wacker (2013) provided a conceptual framework, rooted in behavioral momentum theory, for the study of treatment maintenance that addressed two components: (a) reemergence of problem behavior, and (b) continued expression of appropriate behavior. In the few studies on this topic, focus has been on variables impacting the reemergence of problem behavior, with fewer studies evaluating the persistence of appropriate behavior. Given the findings from applied research related to functional communication training, variables related to response topography, such as response preference, may impact this aspect of maintenance. In the current study, the impact of response preference on persistence was evaluated in the context of functional communication training for individuals who did not exhibit problem behavior (Experiment 1) and for individuals with a history of reinforcement for problem behavior (Experiment 2). High-preferred mands were more persistent than low-preferred mands. These findings suggest that response related variables, such as response preference, impact response persistence and further suggest that response related variables should be considered when developing interventions such as functional communication training. © 2018 Society for the Experimental Analysis of Behavior.

Exploration of Factors Affecting Success of Undergraduate Engineering Majors at a Historically Black University

NASA Astrophysics Data System (ADS)

Igbinoba, Egheosa P.

Blacks are underrepresented amongst persons who earn college degrees in the United States and Black males attend and complete college at a lower rate than Black females (Toldson, Fry Brown, & Sutton, 2009). According to Toldson et al. (2009), this quandary may be attributed to Black males' apathy toward education in general, waning support and ideological challenges toward Pell Grants and affirmative action, cultural incompetency on the part of the 90% White, ethnic makeup of the U.S. teaching force, and the relatively high numbers of Black males who are held back in school. In spite of the dismal statistics regarding Black male academic achievement and matriculation, there are those Black males who do participate in postsecondary education. While many studies have highlighted reasons that Black males do not achieve success in attending and persisting through college, few have adopted the anti-deficit research framework suggested by Harper (2010), identifying reasons Black males do persist in higher education. Although science, technology, engineering, and mathematics careers are identified as those most imperative to the economic competitiveness of the United States, few studies have concentrated solely on engineering majors and fewer, if any, solely on Black male engineering majors at an historically Black college and university. The aim of this study was to address an apparent gap in the literature and invoke theories for recruitment, retention, and success of Black males in engineering degree programs by employing an anti-deficit achievement framework for research of students of color in science, technology, engineering, and mathematics. Data garnered from the study included insight into participants' definitions of success, precollege experiences, factors contributing to the persistence during undergraduate study, and perceptions of attending a historically Black college and university versus a primarily White institution.

Multi-centennial upper-ocean heat content reconstruction using online data assimilation

NASA Astrophysics Data System (ADS)

Perkins, W. A.; Hakim, G. J.

2017-12-01

The Last Millennium Reanalysis (LMR) provides an advanced paleoclimate ensemble data assimilation framework for multi-variate climate field reconstructions over the Common Era. Although reconstructions in this framework with full Earth system models remain prohibitively expensive, recent work has shown improved ensemble reconstruction validation using computationally inexpensive linear inverse models (LIMs). Here we leverage these techniques in pursuit of a new multi-centennial field reconstruction of upper-ocean heat content (OHC), synthesizing model dynamics with observational constraints from proxy records. OHC is an important indicator of internal climate variability and responds to planetary energy imbalances. Therefore, a consistent extension of the OHC record in time will help inform aspects of low-frequency climate variability. We use the Community Climate System Model version 4 (CCSM4) and Max Planck Institute (MPI) last millennium simulations to derive the LIMs, and the PAGES2K v.2.0 proxy database to perform annually resolved reconstructions of upper-OHC, surface air temperature, and wind stress over the last 500 years. Annual OHC reconstructions and uncertainties for both the global mean and regional basins are compared against observational and reanalysis data. We then investigate differences in dynamical behavior at decadal and longer time scales between the reconstruction and simulations in the last-millennium Coupled Model Intercomparison Project version 5 (CMIP5). Preliminary investigation of 1-year forecast skill for an OHC-only LIM shows largely positive spatial grid point local anomaly correlations (LAC) with a global average LAC of 0.37. Compared to 1-year OHC persistence forecast LAC (global average LAC of 0.30), the LIM outperforms the persistence forecasts in the tropical Indo-Pacific region, the equatorial Atlantic, and in certain regions near the Antarctic Circumpolar Current. In other regions, the forecast correlations are less than the persistence case but still positive overall.

Managing climate change refugia for climate adaptation

USGS Publications Warehouse

Morelli, Toni L.; Jackson, Stephen T.

2016-01-01

Refugia have long been studied from paleontological and biogeographical perspectives to understand how populations persisted during past periods of unfavorable climate. Recently, researchers have applied the idea to contemporary landscapes to identify climate change refugia, here defined as areas relatively buffered from contemporary climate change over time that enable persistence of valued physical, ecological, and socio-cultural resources. We differentiate historical and contemporary views, and characterize physical and ecological processes that create and maintain climate change refugia. We then delineate how refugia can fit into existing decision support frameworks for climate adaptation and describe seven steps for managing them. Finally, we identify challenges and opportunities for operationalizing the concept of climate change refugia. Managing climate change refugia can be an important option for conservation in the face of ongoing climate change.

Managing Climate Change Refugia for Climate Adaptation.

PubMed

Morelli, Toni Lyn; Daly, Christopher; Dobrowski, Solomon Z; Dulen, Deanna M; Ebersole, Joseph L; Jackson, Stephen T; Lundquist, Jessica D; Millar, Constance I; Maher, Sean P; Monahan, William B; Nydick, Koren R; Redmond, Kelly T; Sawyer, Sarah C; Stock, Sarah; Beissinger, Steven R

2016-01-01

Refugia have long been studied from paleontological and biogeographical perspectives to understand how populations persisted during past periods of unfavorable climate. Recently, researchers have applied the idea to contemporary landscapes to identify climate change refugia, here defined as areas relatively buffered from contemporary climate change over time that enable persistence of valued physical, ecological, and socio-cultural resources. We differentiate historical and contemporary views, and characterize physical and ecological processes that create and maintain climate change refugia. We then delineate how refugia can fit into existing decision support frameworks for climate adaptation and describe seven steps for managing them. Finally, we identify challenges and opportunities for operationalizing the concept of climate change refugia. Managing climate change refugia can be an important option for conservation in the face of ongoing climate change.

Managing Climate Change Refugia for Climate Adaptation

PubMed Central

Daly, Christopher; Dobrowski, Solomon Z.; Dulen, Deanna M.; Ebersole, Joseph L.; Jackson, Stephen T.; Lundquist, Jessica D.; Millar, Constance I.; Maher, Sean P.; Monahan, William B.; Nydick, Koren R.; Redmond, Kelly T.; Sawyer, Sarah C.; Stock, Sarah; Beissinger, Steven R.

2016-01-01

Refugia have long been studied from paleontological and biogeographical perspectives to understand how populations persisted during past periods of unfavorable climate. Recently, researchers have applied the idea to contemporary landscapes to identify climate change refugia, here defined as areas relatively buffered from contemporary climate change over time that enable persistence of valued physical, ecological, and socio-cultural resources. We differentiate historical and contemporary views, and characterize physical and ecological processes that create and maintain climate change refugia. We then delineate how refugia can fit into existing decision support frameworks for climate adaptation and describe seven steps for managing them. Finally, we identify challenges and opportunities for operationalizing the concept of climate change refugia. Managing climate change refugia can be an important option for conservation in the face of ongoing climate change. PMID:27509088

Computer Modeling of the Instructionally Insensitive Nature of the Texas Assessment of Knowledge and Skills (TAKS) Exam

NASA Astrophysics Data System (ADS)

Pham, Vinh Huy

Stakeholders of the educational system assume that standardized tests are transparently about the subject content being tested and therefore can be used as a metric to measure achievement in outcome-based educational reform. Both analysis of longitudinal data for the Texas Assessment of Knowledge and Skills (TAKS) exam and agent based computer modeling of its underlying theoretical testing framework have yielded results that indicate the exam only rank orders students on a persistent but uncharacterized latent trait across domains tested as well as across years. Such persistent rank ordering of students is indicative of an instructionally insensitive exam. This is problematic in the current atmosphere of high stakes testing which holds teachers, administrators, and school systems accountable for student achievement.

The origin and evolution of assessment criteria for persistent, bioaccumulative and toxic (PBT) chemicals and persistent organic pollutants (POPs).

PubMed

Matthies, Michael; Solomon, Keith; Vighi, Marco; Gilman, Andy; Tarazona, Jose V

2016-09-14

General public concern over the effects of persistent chemicals began in the early 1960s. Since then, significant scientific advances have increased our understanding of persistent, bioaccumulative, and toxic (PBT) chemicals and the properties and processes that influence their fates in, and adverse effects on, human health and the environment. In addition to the scientific advances, a number of legislations and agreements for national, international, and global identification and control of PBT chemicals have been adopted. However, some of the rationales and thoughts that were relied upon when the first criteria were developed to identify and categorize PBT chemicals and then POPs (persistent organic pollutants) have not been carried forward. Criteria have been based upon available data of neutral hydrophobic substances as reference chemicals, derived under laboratory conditions. They evolved over the last decades due to the diversification of the protection aims under various national regulatory frameworks and international agreements, advances in methods for estimation of physical/chemical properties, and the identification of chemicals which are non-traditional POPs. Criteria are not defined purely by science; they also are subject to the aims of policy. This paper offers a historical perspective on the development of criteria for PBT chemicals and POPs. It also offers suggestions for rationalization of protection goals, describes some emerging procedures for identification of compounds of concern, and proposes information that needs to be considered when applying criteria to screening and/or evaluation of new chemicals.

Demography of the ecosystem engineer Crassostrea gigas, related to vertical reef accretion and reef persistence

NASA Astrophysics Data System (ADS)

Walles, Brenda; Mann, Roger; Ysebaert, Tom; Troost, Karin; Herman, Peter M. J.; Smaal, Aad C.

2015-03-01

Marine species characterized as structure building, autogenic ecosystem engineers are recognized worldwide as potential tools for coastal adaptation efforts in the face of sea level rise. Successful employment of ecosystem engineers in coastal protection largely depends on long-term persistence of their structure, which is in turn dependent on the population dynamics of the individual species. Oysters, such as the Pacific oyster (Crassostrea gigas), are recognized as ecosystem engineers with potential for use in coastal protection. Persistence of oyster reefs is strongly determined by recruitment and shell production (growth), processes facilitated by gregarious settlement on extant shell substrate. Although the Pacific oyster has been introduced world-wide, and has formed dense reefs in the receiving coastal waters, the population biology of live oysters and the quantitative mechanisms maintaining these reefs has rarely been studied, hence the aim of the present work. This study had two objectives: (1) to describe the demographics of extant C. gigas reefs, and (2) to estimate vertical reef accretion rates and carbonate production in these oyster reefs. Three long-living oyster reefs (>30 years old), which have not been exploited since their first occurrence, were examined in the Oosterschelde estuary in the Netherlands. A positive reef accretion rate (7.0-16.9 mm year-1 shell material) was observed, consistent with self-maintenance and persistent structure. We provide a framework to predict reef accretion and population persistence under varying recruitment, growth and mortality scenarios.

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

PubMed

Efron, Philip A; Mohr, Alicia M; Bihorac, Azra; Horiguchi, Hiroyuki; Hollen, McKenzie K; Segal, Mark S; Baker, Henry V; Leeuwenburgh, Christiaan; Moldawer, Lyle L; Moore, Frederick A; Brakenridge, Scott C

2018-05-25

As early as the 1990s, chronic critical illness, a distinct syndrome of persistent high-acuity illness requiring management in the ICU, was reported under a variety of descriptive terms including the "neuropathy of critical illness," "myopathy of critical illness," "ICU-acquired weakness," and most recently "post-intensive care unit syndrome." The widespread implementation of targeted shock resuscitation, improved organ support modalities, and evidence-based protocolized ICU care has resulted in significantly decreased in-hospital mortality within surgical ICUs, specifically by reducing early multiple organ failure deaths. However, a new phenotype of multiple organ failure has now emerged with persistent but manageable organ dysfunction, high resource utilization, and discharge to prolonged care facilities. This new multiple organ failure phenotype is now clinically associated with the rapidly increasing incidence of chronic critical illness in critically ill surgery patients. Although the underlying pathophysiology driving chronic critical illness remains incompletely described, the persistent inflammation, immunosuppression, and catabolism syndrome has been proposed as a mechanistic framework in which to explain the increased incidence of chronic critical illness in surgical ICUs. The purpose of this review is to provide a historic perspective of the epidemiologic evolution of multiple organ failure into persistent inflammation, immunosuppression, and catabolism syndrome; describe the mechanism that drives and sustains chronic critical illness, and review the long-term outcomes of surgical patients who develop chronic critical illness. Copyright © 2018 Elsevier Inc. All rights reserved.

Towards a fragment-based approach in gelator design: halogen effects leading to thixotropic, mouldable and self-healing systems in aryl-triazolyl amino acid-based gelators!

PubMed

Srivastava, Bhartendu K; Manheri, Muraleedharan K

2017-04-18

A simple replacement of a H atom by Br transformed non-gelating aryl triazolyl amino acid benzyl ester into a versatile gelator, which formed shape-persistent, self-healing and mouldable gels. The 'bromo-aryl benzyl ester' fragment was then transplanted into another framework, which resulted in similar solvent preference and gelation efficiency.

Interoperative fundus image and report sharing in compliance with integrating the healthcare enterprise conformance and web access to digital imaging and communication in medicine persistent object protocol.

PubMed

Wu, Hui-Qun; Lv, Zheng-Min; Geng, Xing-Yun; Jiang, Kui; Tang, Le-Min; Zhou, Guo-Min; Dong, Jian-Cheng

2013-01-01

To address issues in interoperability between different fundus image systems, we proposed a web eye-picture archiving and communication system (PACS) framework in conformance with digital imaging and communication in medicine (DICOM) and health level 7 (HL7) protocol to realize fundus images and reports sharing and communication through internet. Firstly, a telemedicine-based eye care work flow was established based on integrating the healthcare enterprise (IHE) Eye Care technical framework. Then, a browser/server architecture eye-PACS system was established in conformance with the web access to DICOM persistent object (WADO) protocol, which contains three tiers. In any client system installed with web browser, clinicians could log in the eye-PACS to observe fundus images and reports. Multipurpose internet mail extensions (MIME) type of a structured report is saved as pdf/html with reference link to relevant fundus image using the WADO syntax could provide enough information for clinicians. Some functions provided by open-source Oviyam could be used to query, zoom, move, measure, view DICOM fundus images. Such web eye-PACS in compliance to WADO protocol could be used to store and communicate fundus images and reports, therefore is of great significance for teleophthalmology.

Nominal and functional task difficulty in skill acquisition: Effects on performance in two tests of transfer.

PubMed

Sanli, Elizabeth A; Lee, Timothy D

2015-06-01

The influence of nominal and functional task difficulty during the acquisition of a motor skill was examined in two tests of transfer of learning. The task involved a ballistic, target-directed, finger action. Nominal task difficulty was defined as the distance of the target from the home position. Functional task difficulty was created by manipulating the progression of target distances during practice. Based on the challenge point framework (Guadagnoli & Lee, 2004), we predicted that practice with a set of targets farther away from the performer would benefit from less functional task difficulty, while practice with a closer set of targets would benefit from more functional task difficulty. In single-task transfer tests, learners who practiced using the high nominal task difficulty targets benefitted in terms of persistence of performance over time. In dual-task transfer tests, groups with an intermediate combined (nominal and functional) task difficulty performed with greater persistence over time on tests of transfer than those who practiced with the highest or lowest combined difficulty. Together these findings suggest that the influences of nominal and functional task difficulty during acquisition are weighted differentially depending upon the transfer test context. The challenge point framework does not accurately capture this complex relationship in its current form. Copyright © 2015 Elsevier B.V. All rights reserved.

Evolutionary dynamics for persistent cooperation in structured populations

NASA Astrophysics Data System (ADS)

Li, Yan; Liu, Xinsheng; Claussen, Jens Christian; Guo, Wanlin

2015-06-01

The emergence and maintenance of cooperative behavior is a fascinating topic in evolutionary biology and social science. The public goods game (PGG) is a paradigm for exploring cooperative behavior. In PGG, the total resulting payoff is divided equally among all participants. This feature still leads to the dominance of defection without substantially magnifying the public good by a multiplying factor. Much effort has been made to explain the evolution of cooperative strategies, including a recent model in which only a portion of the total benefit is shared by all the players through introducing a new strategy named persistent cooperation. A persistent cooperator is a contributor who is willing to pay a second cost to retrieve the remaining portion of the payoff contributed by themselves. In a previous study, this model was analyzed in the framework of well-mixed populations. This paper focuses on discussing the persistent cooperation in lattice-structured populations. The evolutionary dynamics of the structured populations consisting of three types of competing players (pure cooperators, defectors, and persistent cooperators) are revealed by theoretical analysis and numerical simulations. In particular, the approximate expressions of fixation probabilities for strategies are derived on one-dimensional lattices. The phase diagrams of stationary states, and the evolution of frequencies and spatial patterns for strategies are illustrated on both one-dimensional and square lattices by simulations. Our results are consistent with the general observation that, at least in most situations, a structured population facilitates the evolution of cooperation. Specifically, here we find that the existence of persistent cooperators greatly suppresses the spreading of defectors under more relaxed conditions in structured populations compared to that obtained in well-mixed populations.

Measuring persistence to hormonal therapy in patients with breast cancer: accounting for temporary treatment discontinuation.

PubMed

Huiart, Laetitia; Ferdynus, Cyril; Dell'Aniello, Sophie; Bakiri, Naciba; Giorgi, Roch; Suissa, Samy

2014-08-01

Several studies have been conducted to estimate persistence to hormonal therapy among women with breast cancer (BC). Most studies focus on first treatment discontinuation. Patients, however, can have numerous periods of treatment discontinuation or treatment exposure. Our objective is to estimate persistence to tamoxifen in patients with BC while accounting for temporary treatment discontinuations and this by using multi-state (MS) models. A cohort of 10,806 women with BC having received at least one prescription of tamoxifen between 1998 and 2008 was constituted from the UK General Practice Research Database. We fitted a semi-Markov model with three states to estimate the probability of being off treatment over a 5-year period while accounting for temporary treatment discontinuations (transition between on treatment and off treatment) and competing risks (recurrence of BC or death). Non-persistence, as estimated from the MS model, ranged from 12.1% (95% confidence interval [95%CI]: 9.2-15.1) at 1 year to 14.9% (95%CI: 11.7-18.1) at 5 years. Estimations of non-persistence based on the Kaplan-Meier model were higher, i.e., 29.3% (95%CI: 28.1-30.6) at 5 years, as well as those obtained from a competing risk model, i.e., 24.0% (95%CI: 22.9-25.1). Most temporary discontinuations (94.7%) lasted less than 6 months. Temporary treatment discontinuations are frequent and should be accounted for when measuring adherence to treatment. MS models can provide a useful framework for this sort of analysis insofar as they help describe patients' complex behavior. This may help tailor interventions that improve persistence to hormonal therapy among women with BC. Copyright © 2014 John Wiley & Sons, Ltd.

A novel low cost pulse excitation source to study trap spectroscopy of persistent luminescent materials

NASA Astrophysics Data System (ADS)

Chandrasekhar, Ngangbam; Singh, Nungleppam Monorajan; Gartia, R. K.

2018-04-01

Luminescent techniques require one or the other source of excitations which may vary from high cost X-rays, γ-rays, β-rays etc. to low cost LED. Persistent luminescent materials or Glow-in-the-Dark phosphors are the optical harvesters which store the optical energy from day light illuminating a whole night. They are so sensitive that they can be excited even with the low light of firefly. Therefore, instead of using a high cost excitation source authors have developed a low cost functioning of excitation source controlling short pulses of LED to excite persistent phosphors with the aid of ExpEYES Junior (Hardware/software framework developed by IUAC, New Delhi). Using this, the authors have excited the sample under investigation upto 10 ms. Trap spectroscopy of the pre-excited sample with LED is studied using Thermoluminescence (TL) technique. In this communication, development of the excitation source is discussed and demonstrate the its usefulness in the study of trap spectroscopy of commercially available CaS:Eu2+, Sm3+. Trapping parameters are also evaluated using Computerized Glow Curve Deconvolution (CGCD) technique.

Social justice as a framework for professional nursing.

PubMed

Boutain, Doris M

2005-09-01

A persistent connection exists between health disparity and societal inequality. Since more research is designed to document, rather than alter, those trends, nurses are called on to reinvest in a social justice agenda. An educational focus on social justice is necessary to prepare future nurses to address health concerns related to how societies are structured. This article reports on how social justice was used as a framework to teach concepts related to professional nursing. The course structure is described, a focus on how the course content was taught is outlined, and conclusions are drawn. Linking content on social justice to professional nursing is important because research indicates that, if societal relationships are more equal, population health indicators between diverse groups become more stable nationally and globally.

Uncertainties in the governance of animal disease: an interdisciplinary framework for analysis

PubMed Central

Fish, Robert; Austin, Zoe; Christley, Robert; Haygarth, Philip M.; Heathwaite, Louise A.; Latham, Sophia; Medd, William; Mort, Maggie; Oliver, David M.; Pickup, Roger; Wastling, Jonathan M.; Wynne, Brian

2011-01-01

Uncertainty is an inherent feature of strategies to contain animal disease. In this paper, an interdisciplinary framework for representing strategies of containment, and analysing how uncertainties are embedded and propagated through them, is developed and illustrated. Analysis centres on persistent, periodic and emerging disease threats, with a particular focus on cryptosporidiosis, foot and mouth disease and avian influenza. Uncertainty is shown to be produced at strategic, tactical and operational levels of containment, and across the different arenas of disease prevention, anticipation and alleviation. The paper argues for more critically reflexive assessments of uncertainty in containment policy and practice. An interdisciplinary approach has an important contribution to make, but is absent from current real-world containment policy. PMID:21624922

Assembling evidence for identifying reservoirs of infection.

PubMed

Viana, Mafalda; Mancy, Rebecca; Biek, Roman; Cleaveland, Sarah; Cross, Paul C; Lloyd-Smith, James O; Haydon, Daniel T

2014-05-01

Many pathogens persist in multihost systems, making the identification of infection reservoirs crucial for devising effective interventions. Here, we present a conceptual framework for classifying patterns of incidence and prevalence, and review recent scientific advances that allow us to study and manage reservoirs simultaneously. We argue that interventions can have a crucial role in enriching our mechanistic understanding of how reservoirs function and should be embedded as quasi-experimental studies in adaptive management frameworks. Single approaches to the study of reservoirs are unlikely to generate conclusive insights whereas the formal integration of data and methodologies, involving interventions, pathogen genetics, and contemporary surveillance techniques, promises to open up new opportunities to advance understanding of complex multihost systems. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Long Duration Testing of a Spacesuit Water Membrane Evaporator Prototype

NASA Technical Reports Server (NTRS)

Bue, Grant C.; Makinen, Janice; Cox, Marlon; Watts, Carly; Campbell, Colin; Vogel, Matthew; Colunga, Aaron

2011-01-01

The Spacesuit Water Membrane Evaporator (SWME) is a heat-rejection device that is being developed to perform thermal control for advanced spacesuits. Cooling is achieved by circulating water from the liquid cooling garment (LCG) through hollow fibers (HoFi?s), which are small hydrophobic tubes. Liquid water remains within the hydrophobic tubes, but water vapor is exhausted to space, thereby removing heat. A SWME test article was tested over the course of a year, for a total of 1200 cumulative hours. In order to evaluate SWME tolerance to contamination due to constituents caused by distillation processes, these constituents were allowed to accumulate in the water as evaporation occurred. A test article was tested over the course of a year for a total of 1200 cumulative hours. The heat rejection performance of the SWME degraded significantly--below 700 W, attributable to the accumulation of rust in the circulating loop and biofilm growth. Bubble elimination capability, a feature that was previously proven with SWME, was compromised during the test, most likely due to loss of hydrophobic properties of the hollow fibers. The utilization of water for heat rejection was shown not to be dependent on test article, life cycle, heat rejection rate, or freezing of the membranes.

Long Duration Testing of a Spacesuit Water Membrane Evaporator Prototype

NASA Technical Reports Server (NTRS)

Bue, Grant C.; Makinen, Janice; Cox, Marlon; Watts, Carly; Campbell, Colin; Vogel, Matthew; Colunga, Aaron; Conger, Bruce

2012-01-01

The Spacesuit Water Membrane Evaporator (SWME) is a heat-rejection device that is being developed to perform thermal control for advanced spacesuits. Cooling is achieved by circulating water from the liquid cooling garment (LCG) through hollow fibers (HoFi s), which are small hydrophobic tubes. Liquid water remains within the hydrophobic tubes, but water vapor is exhausted to space, thereby removing heat. A SWME test article was tested over the course of a year, for a total of 600 cumulative hours. In order to evaluate SWME tolerance to contamination due to constituents caused by distillation processes, these constituents were allowed to accumulate in the water as evaporation occurred. A test article was tested over the course of a year for a total of 600 cumulative hours. The heat rejection performance of the SWME degraded significantly--below 700 W, attributable to the accumulation of rust in the circulating loop and biofilm growth. Bubble elimination capability, a feature that was previously proven with SWME, was compromised during the test, most likely due to loss of hydrophobic properties of the hollow fibers. The utilization of water for heat rejection was shown not to be dependent on test article, life cycle, heat rejection rate, or freezing of the membranes.

Determination of Time Required for Materials Exposed to Oxygen to Return to Reduced Flammability

NASA Technical Reports Server (NTRS)

Harper, Susana; Hirsch, David; Smith, Sarah

2009-01-01

Increased material flammability due to exposure to high oxygen concentrations is a concern from both a safety and operational perspective. Localized, high oxygen concentrations can occur when exiting a higher oxygen concentration environment due to material saturation, as well as oxygen entrapment between barrier materials. Understanding of oxygen diffusion and permeation and its correlation to flammability risks can reduce the likelihood of fires while improving procedures as NASA moves to longer missions with increased extravehicular activities in both spacecraft and off-Earth habitats. This paper examines the time required for common spacecraft materials exposed to oxygen to return to reduced flammability after removal from the increased oxygen concentration environment. Specifically, NASA-STD-6001A maximum oxygen concentration testing and ASTM F-1927 permeability testing were performed on Nomex 4 HT90-40, Tiburon 5 Surgical Drape, Cotton, Extravehicular Mobility Unit (EMU) Liquid-Cooled Ventilation Garment, EMU Thermal Comfort Undergarment, EMU Mosite Foam with Spandex Covering, Advanced Crew Escape Suit (ACES) Outer Cross-section, ACES Liquid Cooled Garment (LCG), ACES O2 Hose Material, Minicel 6 Polyethylene Foam, Minicel Polyethylene Foam with Nomex Covering, Pyrell Polyurethane Foam, and Zotek 7 F-30 Foam.

Optoelectronic stereoscopic device for diagnostics, treatment, and developing of binocular vision

NASA Astrophysics Data System (ADS)

Pautova, Larisa; Elkhov, Victor A.; Ovechkis, Yuri N.

2003-08-01

Operation of the device is based on alternative generation of pictures for left and right eyes on the monitor screen. Controller gives pulses on LCG so that shutter for left or right eye opens synchronously with pictures. The device provides frequency of switching more than 100 Hz, and that is why the flickering is absent. Thus, a separate demonstration of images to the left eye or to the right one in turn is obtained for patients being unaware and creates the conditions of binocular perception clsoe to natural ones without any additional separation of vision fields. LC-cell transfer characteristic coodination with time parameters of monitor screen has enabled to improve stereo image quality. Complicated problem of computer stereo images with LC-glasses is so called 'ghosts' - noise images that come to blocked eye. We reduced its influence by adapting stereo images to phosphor and LC-cells characteristics. The device is intended for diagnostics and treatment of stabismus, amblyopia and other binocular and stereoscopic vision impairments, for cultivating, training and developing of stereoscopic vision, for measurements of horizontal and vertical phoria, phusion reserves, the stereovision acuity and some else, for fixing central scotoma borders, as well as suppression scotoma in strabismus too.

EMI datalib - joining the best of ARC and gLite data libraries

NASA Astrophysics Data System (ADS)

Nilsen, J. K.; Cameron, D.; Devresse, A.; Molnar, Zs; Nagy, Zs; Salichos, M.

2012-12-01

To manage data in the grid, with its jungle of protocols and enormous amount of data in different storage solutions, it is important to have a strong, versatile and reliable data management library. While there are several data management tools and libraries available, they all have different strengths and weaknesses, and it can be hard to decide which tool to use for which purpose. EMI is a collaboration between the European middleware providers aiming to take the best out of each middleware to create one consolidated, all-purpose grid middleware. When EMI started there were two main tools for managing data - gLite had lcg util and the GFAL library, ARC had the ARC data tools and libarcdata2. While different in design and purpose, they both have the same goal; to manage data in the grid. The design of the new EMI datalib was ready by the end of 2011, and a first prototype is now implemented and going through a thorough testing phase. This presentation will give the latest results of the consolidated library together with an overview of the design, test plan and roadmap of EMI datalib.

Alternative foraging strategies enable a mountain ungulate to persist after migration loss

USGS Publications Warehouse

Courtemanch, Alyson B.; Kauffman, Matthew J.; Kilpatrick, Steve; Dewey, Sarah R.

2017-01-01

The persistence of many migratory ungulate populations worldwide is threatened due to anthropogenic impacts to seasonal ranges and migration routes. While many studies have linked migratory ungulate declines to migration disruption or loss, very few have explored the underlying factors that determine whether a population perishes or persists. In some cases, populations undergo severe declines and extirpation after migration loss; however, others appear able to persist as residents. We predict that to persist, populations must replace the traditional benefits of migration by altering the foraging strategies they employ as residents within one seasonal range. We propose the alternative foraging strategies (AFS) hypothesis as a framework for identifying various behavioral strategies that populations may use to cope with migration loss. We tested the hypothesis using the formerly migratory Teton bighorn sheep population in northwest Wyoming, which ceased migrating over 60 yr ago, but has persisted as a resident population. We used global positioning system data to evaluate winter and summer habitat selection and seasonal elevational movements for 28 adult female bighorn sheep (Ovis canadensis) from 2008 to 2010. Resource selection functions revealed that bighorn sheep employ winter foraging strategies to survive as residents by seeking out rugged, high-elevation, windswept ridgelines. Seasonal movement analyses indicated that bighorn sheep undergo a newly documented “abbreviated migration” strategy that is closely synchronized with vegetation green-up patterns within their one range. Bighorn sheep descend 500 m in elevation and travel up to 10 km in spring, gaining access to newly emergent forage approximately 30 d before it appears on their high-elevation winter and summer ranges. Our findings indicate that the Teton bighorn sheep population has persisted due to its habitat selection, AFS, and unique movement patterns, which allow migration loss to be mediated to some extent. The identification of AFS and the habitats that support them can help reveal the underlying benefits of migration and conserve populations in the face of future migration loss.

Deontological and utilitarian ethics: a brief introduction in the context of disorders of consciousness.

PubMed

Playford, Richard C; Roberts, Tom; Playford, E Diane

2015-01-01

The aims of this paper are to discuss three different ethical frameworks; to briefly consider some of the philosophical positions concerning the nature of personhood. Clear consideration of these issues demonstrates the complexity of decision making in persisting disorders of consciousness. Three different ethical frameworks, Kantian deontology, act utilitarianism and rule utilitarianism, are described and three different accounts of personhood are presented and analysed. These result in very different approaches to the management of patients in permanent vegetative states (PVSs), making it possible to argue for withdrawal of clinically assisted nutrition and hydration in all cases, considering the issues on a case by case basis or continuing to treat all patients whatever their wishes. These results explain why doctors often have different views on how to treat patients in PVS, particularly with regard to the withdrawal of clinically assisted nutrition and hydration. Understanding such issues may help clinicians articulate more clearly the reasons for their intuitions surrounding the management of patients in PVSs. Implications for Rehabilitation Patients with persisting disorders of consciousness pose significant dilemmas for clinicians and family members. Utilitarianism is a consequentialist theory, that is, it is concerned with the outcome of our actions to determine their morality. It is the concept that the right action is the one that will result in "the greatest amount of good for the greatest number". Deontological ethics suggests that there are certain sorts of acts that are wrong in themselves independent of the result of such actions. Personhood can be approached from a variety of perspectives including biological, relational, religious and psychological. Understanding different ethical frameworks, and the nature of personhood, may help clinicians articulate more clearly the reasons for their intuitions.

A general framework for multivariate multi-index drought prediction based on Multivariate Ensemble Streamflow Prediction (MESP)

NASA Astrophysics Data System (ADS)

Hao, Zengchao; Hao, Fanghua; Singh, Vijay P.

2016-08-01

Drought is among the costliest natural hazards worldwide and extreme drought events in recent years have caused huge losses to various sectors. Drought prediction is therefore critically important for providing early warning information to aid decision making to cope with drought. Due to the complicated nature of drought, it has been recognized that the univariate drought indicator may not be sufficient for drought characterization and hence multivariate drought indices have been developed for drought monitoring. Alongside the substantial effort in drought monitoring with multivariate drought indices, it is of equal importance to develop a drought prediction method with multivariate drought indices to integrate drought information from various sources. This study proposes a general framework for multivariate multi-index drought prediction that is capable of integrating complementary prediction skills from multiple drought indices. The Multivariate Ensemble Streamflow Prediction (MESP) is employed to sample from historical records for obtaining statistical prediction of multiple variables, which is then used as inputs to achieve multivariate prediction. The framework is illustrated with a linearly combined drought index (LDI), which is a commonly used multivariate drought index, based on climate division data in California and New York in the United States with different seasonality of precipitation. The predictive skill of LDI (represented with persistence) is assessed by comparison with the univariate drought index and results show that the LDI prediction skill is less affected by seasonality than the meteorological drought prediction based on SPI. Prediction results from the case study show that the proposed multivariate drought prediction outperforms the persistence prediction, implying a satisfactory performance of multivariate drought prediction. The proposed method would be useful for drought prediction to integrate drought information from various sources for early drought warning.

Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes.

PubMed

Dong, Xu; Foteinou, Panagiota T; Calvano, Steven E; Lowry, Stephen F; Androulakis, Ioannis P

2010-02-18

Inflammation is a highly complex biological response evoked by many stimuli. A persistent challenge in modeling this dynamic process has been the (nonlinear) nature of the response that precludes the single-variable assumption. Systems-based approaches offer a promising possibility for understanding inflammation in its homeostatic context. In order to study the underlying complexity of the acute inflammatory response, an agent-based framework is developed that models the emerging host response as the outcome of orchestrated interactions associated with intricate signaling cascades and intercellular immune system interactions. An agent-based modeling (ABM) framework is proposed to study the nonlinear dynamics of acute human inflammation. The model is implemented using NetLogo software. Interacting agents involve either inflammation-specific molecules or cells essential for the propagation of the inflammatory reaction across the system. Spatial orientation of molecule interactions involved in signaling cascades coupled with the cellular heterogeneity are further taken into account. The proposed in silico model is evaluated through its ability to successfully reproduce a self-limited inflammatory response as well as a series of scenarios indicative of the nonlinear dynamics of the response. Such scenarios involve either a persistent (non)infectious response or innate immune tolerance and potentiation effects followed by perturbations in intracellular signaling molecules and cascades. The ABM framework developed in this study provides insight on the stochastic interactions of the mediators involved in the propagation of endotoxin signaling at the cellular response level. The simulation results are in accordance with our prior research effort associated with the development of deterministic human inflammation models that include transcriptional dynamics, signaling, and physiological components. The hypothetical scenarios explored in this study would potentially improve our understanding of how manipulating the behavior of the molecular species could manifest into emergent behavior of the overall system.

Conceptual model and economic experiments to explain nonpersistence and enable mechanism designs fostering behavioral change.

PubMed

Djawadi, Behnud Mir; Fahr, René; Turk, Florian

2014-12-01

Medical nonpersistence is a worldwide problem of striking magnitude. Although many fields of studies including epidemiology, sociology, and psychology try to identify determinants for medical nonpersistence, comprehensive research to explain medical nonpersistence from an economics perspective is rather scarce. The aim of the study was to develop a conceptual framework that augments standard economic choice theory with psychological concepts of behavioral economics to understand how patients' preferences for discontinuing with therapy arise over the course of the medical treatment. The availability of such a framework allows the targeted design of mechanisms for intervention strategies. Our conceptual framework models the patient as an active economic agent who evaluates the benefits and costs for continuing with therapy. We argue that a combination of loss aversion and mental accounting operations explains why patients discontinue with therapy at a specific point in time. We designed a randomized laboratory economic experiment with a student subject pool to investigate the behavioral predictions. Subjects continue with therapy as long as experienced utility losses have to be compensated. As soon as previous losses are evened out, subjects perceive the marginal benefit of persistence lower than in the beginning of the treatment. Consequently, subjects start to discontinue with therapy. Our results highlight that concepts of behavioral economics capture the dynamic structure of medical nonpersistence better than does standard economic choice theory. We recommend that behavioral economics should be a mandatory part of the development of possible intervention strategies aimed at improving patients' compliance and persistence behavior. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Chemical hazards analysis of resilient flooring for healthcare.

PubMed

Lent, Tom; Silas, Julie; Vallette, Jim

2010-01-01

This article addresses resilient flooring, evaluating the potential health effects of vinyl flooring and the leading alternatives-synthetic rubber, polyolefin, and linoleum-currently used in the healthcare marketplace. The study inventories chemicals incorporated as components of each of the four material types or involved in their life cycle as feedstocks, intermediary chemicals, or emissions. It then characterizes those chemicals using a chemical hazard-based framework that addresses persistence and bioaccumulation, human toxicity, and human exposures.

Framework for Evaluating the Health Impact of the Scale-Up of Malaria Control Interventions on All-Cause Child Mortality in Sub-Saharan Africa.

PubMed

Yé, Yazoume; Eisele, Thomas P; Eckert, Erin; Korenromp, Eline; Shah, Jui A; Hershey, Christine L; Ivanovich, Elizabeth; Newby, Holly; Carvajal-Velez, Liliana; Lynch, Michael; Komatsu, Ryuichi; Cibulskis, Richard E; Moore, Zhuzhi; Bhattarai, Achuyt

2017-09-01

Concerted efforts from national and international partners have scaled up malaria control interventions, including insecticide-treated nets, indoor residual spraying, diagnostics, prompt and effective treatment of malaria cases, and intermittent preventive treatment during pregnancy in sub-Saharan Africa (SSA). This scale-up warrants an assessment of its health impact to guide future efforts and investments; however, measuring malaria-specific mortality and the overall impact of malaria control interventions remains challenging. In 2007, Roll Back Malaria's Monitoring and Evaluation Reference Group proposed a theoretical framework for evaluating the impact of full-coverage malaria control interventions on morbidity and mortality in high-burden SSA countries. Recently, several evaluations have contributed new ideas and lessons to strengthen this plausibility design. This paper harnesses that new evaluation experience to expand the framework, with additional features, such as stratification, to examine subgroups most likely to experience improvement if control programs are working; the use of a national platform framework; and analysis of complete birth histories from national household surveys. The refined framework has shown that, despite persisting data challenges, combining multiple sources of data, considering potential contributions from both fundamental and proximate contextual factors, and conducting subnational analyses allows identification of the plausible contributions of malaria control interventions on malaria morbidity and mortality.

A Conceptual Framework for Planning Systemic Human Adaptation to Global Warming.

PubMed

Tait, Peter W; Hanna, Elizabeth G

2015-08-31

Human activity is having multiple, inter-related effects on ecosystems. Greenhouse gas emissions persisting along current trajectories threaten to significantly alter human society. At 0.85 °C of anthropogenic warming, deleterious human impacts are acutely evident. Additional warming of 0.5 °C-1.0 °C from already emitted CO₂ will further intensify extreme heat and damaging storm events. Failing to sufficiently address this trend will have a heavy human toll directly and indirectly on health. Along with mitigation efforts, societal adaptation to a warmer world is imperative. Adaptation efforts need to be significantly upscaled to prepare society to lessen the public health effects of rising temperatures. Modifying societal behaviour is inherently complex and presents a major policy challenge. We propose a social systems framework for conceptualizing adaptation that maps out three domains within the adaptation policy landscape: acclimatisation, behavioural adaptation and technological adaptation, which operate at societal and personal levels. We propose that overlaying this framework on a systems approach to societal change planning methods will enhance governments' capacity and efficacy in strategic planning for adaptation. This conceptual framework provides a policy oriented planning assessment tool that will help planners match interventions to the behaviours being targeted for change. We provide illustrative examples to demonstrate the framework's application as a planning tool.

The critical domain size of stochastic population models.

PubMed

Reimer, Jody R; Bonsall, Michael B; Maini, Philip K

2017-02-01

Identifying the critical domain size necessary for a population to persist is an important question in ecology. Both demographic and environmental stochasticity impact a population's ability to persist. Here we explore ways of including this variability. We study populations with distinct dispersal and sedentary stages, which have traditionally been modelled using a deterministic integrodifference equation (IDE) framework. Individual-based models (IBMs) are the most intuitive stochastic analogues to IDEs but yield few analytic insights. We explore two alternate approaches; one is a scaling up to the population level using the Central Limit Theorem, and the other a variation on both Galton-Watson branching processes and branching processes in random environments. These branching process models closely approximate the IBM and yield insight into the factors determining the critical domain size for a given population subject to stochasticity.

Using self-determination theory to explain sport persistence and dropout in adolescent athletes.

PubMed

García Calvo, Tomás; Cervelló, Eduardo; Jiménez, Ruth; Iglesias, Damián; Moreno Murcia, Juan Antonio

2010-11-01

Motivational characteristics are influential in shaping adolescents' desire to persist in sport or to discontinue their sport participation. Self-determination theory (Deci & Ryan, 2000) was utilized as the theoretical framework for this study. This theory examines whether sustained participatory involvement, defined as continued participation in the sport through the next year, was influenced by individuals' self-determined motivation and by the fulfillment of the three basic psychological needs of autonomy, competence, and relatedness. Four hundred ninety two soccer players between the ages of 13 and 17 years comprised the sample. Results indicated sport dropout was explained by higher levels of amotivation, external regulation, and introjected regulation and by lower satisfaction of relatedness and autonomy needs. The findings of this study contribute to the knowledge base on sport dropout as they supported many of self-determination theory.

Jeopardy not bonus status for African American women in the work force: why does the myth of advantage persist?

PubMed

Sanchez-Hucles, J V

1997-10-01

African American women in the United States have a long history of employment outside of their homes. Their experiences are unique from other groups of majority and minority men and women due to the interaction of race, gender, and class. Despite long-standing and continuing struggles against discrimination, harassment, low pay, tokenism, and stereotypes, a myth that African American women enjoy a bonus or advantaged status in the work force has developed and persisted. In this article, Black women's work force experiences are examined from a social constructionist framework, misperceptions of Black women are critiqued, explanations are developed that explain the unique status of African American women and recommendations are proposed to eradicate the discrimination and marginal status that Black women have endured in the work force.

The ConNECT Framework: a model for advancing behavioral medicine science and practice to foster health equity

PubMed Central

Alcaraz, Kassandra I.; Sly, Jamilia; Ashing, Kimlin; Fleisher, Linda; Gil-Rivas, Virginia; Ford, Sabrina; Yi, Jean C.; Lu, Qian; Meade, Cathy D.; Menon, Usha; Gwede, Clement K.

2017-01-01

Health disparities persist despite ongoing efforts. Given the United States’ rapidly changing demography and socio-cultural diversity, a paradigm shift in behavioral medicine is needed to advance research and interventions focused on health equity. This paper introduces the Con-NECT Framework as a model to link the sciences of behavioral medicine and health equity with the goal of achieving equitable health and outcomes in the twenty-first century. We first evaluate the state of health equity efforts in behavioral medicine science and identify key opportunities to advance the field. We then discuss and present actionable recommendations related to ConNECT’s five broad and synergistic principles: (1) Integrating Context; (2) Fostering a Norm of Inclusion; (3) Ensuring Equitable Diffusion of Innovations; (4) Harnessing Communication Technology; and (5) Prioritizing Specialized Training. The framework holds significant promise for furthering health equity and ushering in a new and refreshing era of behavioral medicine science and practice. PMID:27509892

The ConNECT Framework: a model for advancing behavioral medicine science and practice to foster health equity.

PubMed

Alcaraz, Kassandra I; Sly, Jamilia; Ashing, Kimlin; Fleisher, Linda; Gil-Rivas, Virginia; Ford, Sabrina; Yi, Jean C; Lu, Qian; Meade, Cathy D; Menon, Usha; Gwede, Clement K

2017-02-01

Health disparities persist despite ongoing efforts. Given the United States' rapidly changing demography and socio-cultural diversity, a paradigm shift in behavioral medicine is needed to advance research and interventions focused on health equity. This paper introduces the ConNECT Framework as a model to link the sciences of behavioral medicine and health equity with the goal of achieving equitable health and outcomes in the twenty-first century. We first evaluate the state of health equity efforts in behavioral medicine science and identify key opportunities to advance the field. We then discuss and present actionable recommendations related to ConNECT's five broad and synergistic principles: (1) Integrating Context; (2) Fostering a Norm of Inclusion; (3) Ensuring Equitable Diffusion of Innovations; (4) Harnessing Communication Technology; and (5) Prioritizing Specialized Training. The framework holds significant promise for furthering health equity and ushering in a new and refreshing era of behavioral medicine science and practice.

ADEpedia: a scalable and standardized knowledge base of Adverse Drug Events using semantic web technology.

PubMed

Jiang, Guoqian; Solbrig, Harold R; Chute, Christopher G

2011-01-01

A source of semantically coded Adverse Drug Event (ADE) data can be useful for identifying common phenotypes related to ADEs. We proposed a comprehensive framework for building a standardized ADE knowledge base (called ADEpedia) through combining ontology-based approach with semantic web technology. The framework comprises four primary modules: 1) an XML2RDF transformation module; 2) a data normalization module based on NCBO Open Biomedical Annotator; 3) a RDF store based persistence module; and 4) a front-end module based on a Semantic Wiki for the review and curation. A prototype is successfully implemented to demonstrate the capability of the system to integrate multiple drug data and ontology resources and open web services for the ADE data standardization. A preliminary evaluation is performed to demonstrate the usefulness of the system, including the performance of the NCBO annotator. In conclusion, the semantic web technology provides a highly scalable framework for ADE data source integration and standard query service.

Significance and Clinical Management of Persistent Low-Level Viremia and Very-Low-Level Viremia in HIV-1-Infected Patients

PubMed Central

Kelly, Sean; Li, Jonathan Z.; Harrigan, P. Richard; Taiwo, Babafemi

2014-01-01

A goal of HIV therapy is to sustain suppression of the plasma viral load below the detection limits of clinical assays. However, widely followed treatment guidelines diverge in their interpretation and recommended management of persistent viremia of low magnitude, reflecting the limited evidence base for this common clinical finding. Here, we review the incidence, risk factors, and potential consequences of low-level HIV viremia (LLV; defined in this review as a viremia level of 50 to 500 copies/ml) and very-low-level viremia (VLLV; defined as a viremia level of <50 copies/ml detected by clinical assays that have quantification cutoffs of <50 copies/ml). Using this framework, we discuss practical issues related to the diagnosis and management of patients experiencing persistent LLV and VLLV. Compared to viral suppression at <50 or 40 copies/ml, persistent LLV is associated with increased risk of antiretroviral drug resistance and overt virologic failure. Higher immune activation and HIV transmission may be additional undesirable consequences in this population. It is uncertain whether LLV of <200 copies/ml confers independent risks, as this level of viremia may reflect assay-dependent artifacts or biologically meaningful events during suppression. Resistance genotyping should be considered in patients with persistent LLV when feasible, and treatment should be modified if resistance is detected. There is a dearth of clinical evidence to guide management when genotyping is not feasible. Increased availability of genotypic assays for samples with viral loads of <400 copies/ml is needed. PMID:24733471

A Study of The Influence of Advising on Underrepresented Minority Undergraduate Student Persistence in STEM

NASA Astrophysics Data System (ADS)

Weir, Michael J.

In the United States, undergraduate underrepresented minority (URM) students tend to change out of declared majors in science, technology, engineering and math (STEM) disciplines at a rate of nearly sixty percent prior to earning a post secondary degree. This phenomenon contributes to a general concern that the United States is not producing enough STEM trained skilled workers to meet future employment needs of industry and government. Although there has been research developed to examine how to increase the numbers of URM students enrolling in STEM programs at higher education institutions, retention of these students remains critical. One area of increasing focus for researchers is to understand how multiple factors impact the college experience of URM students and how those factors may contribute to the student decision to persist in earning a STEM disciple degree. This research study is a phenomenological mixed method study that examines how students experience the phenomenon of advising and the influence of the advising experience of undergraduate URM students on their likelihood of persisting in STEM at a northeast US technology oriented post secondary institution. Persistence, from the perspective of the student, is driven by cognitive psychological attributes such as confidence, motivation and self-efficacy. Utilizing a Social Cognitive theoretical framework, this study examines how three distinct undergraduate URM student populations enrolled in; an Academic Services Program, Honors College, and the general undergraduate population at this institution experience advising and how their experiences may influence their propensity to persist in earning a STEM oriented degree.

Exploring individual differences in task switching: Persistence and other personality traits related to anterior cingulate cortex function.

PubMed

Umemoto, A; Holroyd, C B

2016-01-01

Anterior cingulate cortex (ACC) is involved in cognitive control and decision-making but its precise function is still highly debated. Based on evidence from lesion, neurophysiological, and neuroimaging studies, we have recently proposed a critical role for ACC in motivating extended behaviors according to learned task values (Holroyd and Yeung, 2012). Computational simulations based on this theory suggest a hierarchical mechanism in which a caudal division of ACC selects and applies control over task execution, and a rostral division of ACC facilitates switches between tasks according to a higher task strategy (Holroyd and McClure, 2015). This theoretical framework suggests that ACC may contribute to personality traits related to persistence and reward sensitivity (Holroyd and Umemoto, 2016). To explore this possibility, we carried out a voluntary task switching experiment in which on each trial participants freely chose one of two tasks to perform, under the condition that they try to select the tasks "at random" and equally often. The participants also completed several questionnaires that assessed personality trait related to persistence, apathy, anhedonia, and rumination, in addition to the Big 5 personality inventory. Among other findings, we observed greater compliance with task instructions by persistent individuals, as manifested by a greater facility with switching between tasks, which is suggestive of increased engagement of rostral ACC. © 2016 Elsevier B.V. All rights reserved.

Persistent Topology and Metastable State in Conformational Dynamics

PubMed Central

Chang, Huang-Wei; Bacallado, Sergio; Pande, Vijay S.; Carlsson, Gunnar E.

2013-01-01

The large amount of molecular dynamics simulation data produced by modern computational models brings big opportunities and challenges to researchers. Clustering algorithms play an important role in understanding biomolecular kinetics from the simulation data, especially under the Markov state model framework. However, the ruggedness of the free energy landscape in a biomolecular system makes common clustering algorithms very sensitive to perturbations of the data. Here, we introduce a data-exploratory tool which provides an overview of the clustering structure under different parameters. The proposed Multi-Persistent Clustering analysis combines insights from recent studies on the dynamics of systems with dominant metastable states with the concept of multi-dimensional persistence in computational topology. We propose to explore the clustering structure of the data based on its persistence on scale and density. The analysis provides a systematic way to discover clusters that are robust to perturbations of the data. The dominant states of the system can be chosen with confidence. For the clusters on the borderline, the user can choose to do more simulation or make a decision based on their structural characteristics. Furthermore, our multi-resolution analysis gives users information about the relative potential of the clusters and their hierarchical relationship. The effectiveness of the proposed method is illustrated in three biomolecules: alanine dipeptide, Villin headpiece, and the FiP35 WW domain. PMID:23565139

Genotypes and Haplotypes of the Estrogen Receptor α Gene (ESR1) Are Associated With Female-to-Male Gender Dysphoria.

PubMed

Cortés-Cortés, Joselyn; Fernández, Rosa; Teijeiro, Nerea; Gómez-Gil, Esther; Esteva, Isabel; Almaraz, Mari Cruz; Guillamón, Antonio; Pásaro, Eduardo

2017-03-01

Gender dysphoria, a marked incongruence between one's experienced gender and biological sex, is commonly believed to arise from discrepant cerebral and genital sexual differentiation. With the discovery that estrogen receptor β is associated with female-to-male (FtM) but not with male-to-female (MtF) gender dysphoria, and given estrogen receptor α involvement in central nervous system masculinization, it was hypothesized that estrogen receptor α, encoded by the ESR1 gene, also might be implicated. To investigate whether ESR1 polymorphisms (TA)n-rs3138774, PvuII-rs2234693, and XbaI-rs9340799 and their haplotypes are associated with gender dysphoria in adults. Molecular analysis was performed in peripheral blood samples from 183 FtM subjects, 184 MtF subjects, and 394 sex- and ethnically-matched controls. Genotype and haplotype analyses of the (TA)n-rs3138774, PvuII-rs2234693, and XbaI-rs9340799 polymorphisms. Allele and genotype frequencies for the polymorphism XbaI were statistically significant only in FtM vs control XX subjects (P = .021 and P = .020). In XX individuals, the A/G genotype was associated with a low risk of gender dysphoria (odds ratio [OR] = 0.34; 95% CI = 0.16-0.74; P = .011); in XY individuals, the A/A genotype implied a low risk of gender dysphoria (OR = 0.39; 95% CI = 0.17-0.89; P = .008). Binary logistic regression showed partial effects for all three polymorphisms in FtM but not in MtF subjects. The three polymorphisms were in linkage disequilibrium: a small number of TA repeats was linked to the presence of PvuII and XbaI restriction sites (haplotype S-T-A), and a large number of TA repeats was linked to the absence of these restriction sites (haplotype L-C-G). In XX individuals, the presence of haplotype L-C-G carried a low risk of gender dysphoria (OR = 0.66; 95% CI = 0.44-0.99; P = .046), whereas the presence of haplotype L-C-A carried a high susceptibility to gender dysphoria (OR = 3.96; 95% CI = 1.04-15.02; P = .044). Global haplotype was associated with FtM gender dysphoria (P = .017) but not with MtF gender dysphoria. XbaI-rs9340799 is involved in FtM gender dysphoria in adults. Our findings suggest different genetic programs for gender dysphoria in men and women. Cortés-Cortés J, Fernández R, Teijeiro N, et al. Genotypes and Haplotypes of the Estrogen Receptor α Gene (ESR1) Are Associated With Female-to-Male Gender Dysphoria. J Sex Med 2017;14:464-472. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Analysis of Unit-Level Changes in Operations with Increased SPP Wind from EPRI/LCG Balancing Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadley, Stanton W

2012-01-01

Wind power development in the United States is outpacing previous estimates for many regions, particularly those with good wind resources. The pace of wind power deployment may soon outstrip regional capabilities to provide transmission and integration services to achieve the most economic power system operation. Conversely, regions such as the Southeastern United States do not have good wind resources and will have difficulty meeting proposed federal Renewable Portfolio Standards with local supply. There is a growing need to explore innovative solutions for collaborating between regions to achieve the least cost solution for meeting such a renewable energy mandate. The Departmentmore » of Energy funded the project 'Integrating Midwest Wind Energy into Southeast Electricity Markets' to be led by EPRI in coordination with the main authorities for the regions: SPP, Entergy, TVA, Southern Company and OPC. EPRI utilized several subcontractors for the project including LCG, the developers of the model UPLAN. The study aims to evaluate the operating cost benefits of coordination of scheduling and balancing for Southwest Power Pool (SPP) wind transfers to Southeastern Electric Reliability Council (SERC) Balancing Authorities (BAs). The primary objective of this project is to analyze the benefits of regional cooperation for integrating mid-western wind energy into southeast electricity markets. Scenarios were defined, modeled and investigated to address production variability and uncertainty and the associated balancing of large quantities of wind power in SPP and delivery to energy markets in the southern regions of the SERC. DOE funded Oak Ridge National Laboratory to provide additional support to the project, including a review of results and any side analysis that may provide additional insight. This report is a unit-by-unit analysis of changes in operations due to the different scenarios used in the overall study. It focuses on the change in capacity factors and the number of start-ups required for each unit since those criteria summarize key aspects of plant operations, how often are they called upon and how much do they operate. The primary analysis of the overall project is based on security-constrained unit commitment (SCUC) and economic dispatch (SCED) simulations of the SPP-SERC regions as modeled for the year 2022. The SCUC/SCED models utilized for the project were developed through extensive consultation with the project utility partners, to ensure the various regions and operational practices are represented as best as possible in the model. SPP, Entergy, Oglethorpe Power Company (OPC), Southern Company, and the Tennessee Valley Authority (TVA) actively participated in the project providing input data for the models and review of simulation results and conclusions. While other SERC utility systems are modeled, the listed SERC utilities were explicitly included as active participants in the project due to the size of their load and relative proximity to SPP for importing wind energy.« less

Persistence of Salmonid Redds

NASA Astrophysics Data System (ADS)

Buffington, J. M.; Buxton, T.; Fremier, A. K.; Hassan, M. A.; Yager, E.

2013-12-01

The construction of redds by spawning salmonids modifies fluvial processes in ways that are beneficial to egg and embryo survival. Redd topography induces hyporheic flow that oxygenates embryos incubating within the streambed and creates form drag that reduces bed mobility and scour of salmonid eggs. Winnowing of fine material during redd construction also coarsens the streambed, increasing bed porosity and hyporheic flow and reducing bed mobility. In addition to the biological benefits, redds may influence channel morphology by altering channel hydraulics and bed load transport rates depending on the size and extent of redds relative to the size of the channel. A key question is how long do the physical and biological effects of redds last? Field observations indicate that in some basins redds are ephemeral, with redd topography rapidly erased by subsequent floods, while in other basins, redds can persist for years. We hypothesize that redd persistence is a function of basin hydrology, sediment supply, and characteristics of the spawning fish. Hydrology controls the frequency and magnitude of bed mobilizing flows following spawning, while bed load supply (volume and caliber) controls the degree of textural fining and consequent bed mobility after spawning, as well as the potential for burial of redd features. The effectiveness of flows in terms of their magnitude and duration depend on hydroclimate (i.e., snowmelt, rainfall, or transitional hydrographs), while bed load supply depends on basin geology, land use, and natural disturbance regimes (e.g., wildfire). Location within the stream network may also influence redd persistence. In particular, lakes effectively trap sediment and regulate downstream flow, which may promote long-lived redds in stream reaches below lakes. These geomorphic controls are modulated by biological factors: fish species (size of fish controls size of redds and magnitude of streambed coarsening); life history (timing of spawning and incubation relative to high flows); and population size (density of redds and extent of streambed alteration within a given reach). Species and life history also control the location of spawning within the basin, dictating the flow and sediment supply regimes. A theoretical framework is developed for predicting redd persistence as a function of the above physical and biological factors. We expect that long-lived redds will indicate either that the river is not competent to re-work the effects of spawning or that spawning occurs after peak flow events that are capable of modifying redd features. The longevity of redds and their associated effects on fluvial processes also provides a measure of the degree of potential ecological conditioning for future generations of fish. Future work will test the framework in field and laboratory settings.

Historical trauma: politics of a conceptual framework.

PubMed

Prussing, Erica

2014-06-01

The concept of historical trauma (HT) is compelling: Colonialism has set forth cumulative cycles of adversity that promote morbidity and mortality at personal and collective levels, with especially strong mental health impacts. Yet as ongoing community-based as well as scholarly discussions attest, lingering questions continue to surround HT as a framework for understanding the relationships between colonialism and indigenous mental health. Through an overview of 30 recent peer-reviewed publications that aim to clarify, define, measure, and interpret how HT impacts American Indian and Alaska Native (AIAN) mental health, this paper examines how the conceptual framework of HT has circulated in ways shaped by interactions among three prominent research approaches: evidence-based, culturally relevant, and decolonizing. All define current approaches to AIAN mental health research, but each sets forth different conceptualizations of the connections between colonialism and psychological distress. The unfolding trajectory of research about HT reflects persistent tensions in how these frameworks interact, but also possibilities for better integrating them. These considerations aim to advance conversations about the politics of producing knowledge about AIAN mental health, and support ongoing calls for greater political pluralism in mental health research. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Beyond exposure, sensitivity and adaptive capacity: A response based ecological framework to assess species climate change vulnerability

USGS Publications Warehouse

Fortini, Lucas B.; Schubert, Olivia

2017-01-01

As the impacts of global climate change on species are increasingly evident, there is a clear need to adapt conservation efforts worldwide. Species vulnerability assessments (VAs) are increasingly used to summarize all relevant information to determine a species’ potential vulnerability to climate change and are frequently the first step in informing climate adaptation efforts. VAs commonly integrate multiple sources of information by utilizing a framework that distinguishes factors relevant to species exposure, sensitivity, and adaptive capacity. However, this framework was originally developed for human systems, and its use to evaluate species vulnerability has serious practical and theoretical limitations. By instead defining vulnerability as the degree to which a species is unable to exhibit any of the responses necessary for persistence under climate change (i.e., toleration of projected changes, migration to new climate-compatible areas, enduring in microrefugia, and evolutionary adaptation), we can bring VAs into the realm of ecological science without applying borrowed abstract concepts that have consistently challenged species-centric research and management. This response-based framework to assess species vulnerability to climate change allows better integration of relevant ecological data and past research, yielding results with much clearer implications for conservation and research prioritization.

Ecological mechanisms underpinning climate adaptation services.

PubMed

Lavorel, Sandra; Colloff, Matthew J; McIntyre, Sue; Doherty, Michael D; Murphy, Helen T; Metcalfe, Daniel J; Dunlop, Michael; Williams, Richard J; Wise, Russell M; Williams, Kristen J

2015-01-01

Ecosystem services are typically valued for their immediate material or cultural benefits to human wellbeing, supported by regulating and supporting services. Under climate change, with more frequent stresses and novel shocks, 'climate adaptation services', are defined as the benefits to people from increased social ability to respond to change, provided by the capability of ecosystems to moderate and adapt to climate change and variability. They broaden the ecosystem services framework to assist decision makers in planning for an uncertain future with new choices and options. We present a generic framework for operationalising the adaptation services concept. Four steps guide the identification of intrinsic ecological mechanisms that facilitate the maintenance and emergence of ecosystem services during periods of change, and so materialise as adaptation services. We applied this framework for four contrasted Australian ecosystems. Comparative analyses enabled by the operational framework suggest that adaptation services that emerge during trajectories of ecological change are supported by common mechanisms: vegetation structural diversity, the role of keystone species or functional groups, response diversity and landscape connectivity, which underpin the persistence of function and the reassembly of ecological communities under severe climate change and variability. Such understanding should guide ecosystem management towards adaptation planning. © 2014 John Wiley & Sons Ltd.

Ecosystem Services and Climate Change Considerations for ...

EPA Pesticide Factsheets

Freshwater habitats provide fishable, swimmable and drinkable resources and are a nexus of geophysical and biological processes. These processes in turn influence the persistence and sustainability of populations, communities and ecosystems. Climate change and landuse change encompass numerous stressors of potential exposure, including the introduction of toxic contaminants, invasive species, and disease in addition to physical drivers such as temperature and hydrologic regime. A systems approach that includes the scientific and technologic basis of assessing the health of ecosystems is needed to effectively protect human health and the environment. The Integrated Environmental Modeling Framework “iemWatersheds” has been developed as a consistent and coherent means of forecasting the cumulative impact of co-occurring stressors. The Framework consists of three facilitating technologies: Data for Environmental Modeling (D4EM) that automates the collection and standardization of input data; the Framework for Risk Assessment of Multimedia Environmental Systems (FRAMES) that manages the flow of information between linked models; and the Supercomputer for Model Uncertainty and Sensitivity Evaluation (SuperMUSE) that provides post-processing and analysis of model outputs, including uncertainty and sensitivity analysis. Five models are linked within the Framework to provide multimedia simulation capabilities for hydrology and water quality processes: the Soil Water

The evolution of personality variation in humans and other animals.

PubMed

Nettle, Daniel

2006-09-01

A comprehensive evolutionary framework for understanding the maintenance of heritable behavioral variation in humans is yet to be developed. Some evolutionary psychologists have argued that heritable variation will not be found in important, fitness-relevant characteristics because of the winnowing effect of natural selection. This article propounds the opposite view. Heritable variation is ubiquitous in all species, and there are a number of frameworks for understanding its persistence. The author argues that each of the Big Five dimensions of human personality can be seen as the result of a trade-off between different fitness costs and benefits. As there is no unconditionally optimal value of these trade-offs, it is to be expected that genetic diversity will be retained in the population. ((c) 2006 APA, all rights reserved).

Predicting Predator Recognition in a Changing World.

PubMed

Carthey, Alexandra J R; Blumstein, Daniel T

2018-02-01

Through natural as well as anthropogenic processes, prey can lose historically important predators and gain novel ones. Both predator gain and loss frequently have deleterious consequences. While numerous hypotheses explain the response of individuals to novel and familiar predators, we lack a unifying conceptual model that predicts the fate of prey following the introduction of a novel or a familiar (reintroduced) predator. Using the concept of eco-evolutionary experience, we create a new framework that allows us to predict whether prey will recognize and be able to discriminate predator cues from non-predator cues and, moreover, the likely persistence outcomes for 11 different predator-prey interaction scenarios. This framework generates useful and testable predictions for ecologists, conservation scientists, and decision-makers. Copyright © 2017 Elsevier Ltd. All rights reserved.

An Integrative Research Framework to Unravel the Interplay of Natural Hazards and Vulnerabilities

NASA Astrophysics Data System (ADS)

Di Baldassarre, Giuliano; Nohrstedt, Daniel; Mârd, Johanna; Burchardt, Steffi; Albin, Cecilia; Bondesson, Sara; Breinl, Korbinian; Deegan, Frances M.; Fuentes, Diana; Lopez, Marc Girons; Granberg, Mikael; Nyberg, Lars; Nyman, Monika Rydstedt; Rhodes, Emma; Troll, Valentin; Young, Stephanie; Walch, Colin; Parker, Charles F.

2018-03-01

Climate change, globalization, urbanization, social isolation, and increased interconnectedness between physical, human, and technological systems pose major challenges to disaster risk reduction (DRR). Subsequently, economic losses caused by natural hazards are increasing in many regions of the world, despite scientific progress, persistent policy action, and international cooperation. We argue that these dramatic figures call for novel scientific approaches and new types of data collection to integrate the two main approaches that still dominate the science underpinning DRR: the hazard paradigm and the vulnerability paradigm. Building from these two approaches, here we propose a research framework that specifies the scope of enquiry, concepts, and general relations among phenomena. We then discuss the essential steps to advance systematic empirical research and evidence-based DRR policy action.

Rasch Model Analysis with the BICAL Computer Program

DTIC Science & Technology

1976-09-01

and persons which lead to measures that persist from trial to trial . The measurement model is essential in this process because it provides a framework...and his students. Section 15 two derives the estimating equations for the Bernoulli (i.e. one trial per task) form : " and then generalizes to the...Binomial form (several trials per task). Finall) goodness of fit tests are presented for assessing the adequacy of the calibration. t { ) I I I 41 CHAPTER

Investigating the predictive validity of implicit and explicit measures of motivation in problem-solving behavioural tasks.

PubMed

Keatley, David; Clarke, David D; Hagger, Martin S

2013-09-01

Research into the effects of individuals'autonomous motivation on behaviour has traditionally adopted explicit measures and self-reported outcome assessment. Recently, there has been increased interest in the effects of implicit motivational processes underlying behaviour from a self-determination theory (SDT) perspective. The aim of the present research was to provide support for the predictive validity of an implicit measure of autonomous motivation on behavioural persistence on two objectively measurable tasks. SDT and a dual-systems model were adopted as frameworks to explain the unique effects offered by explicit and implicit autonomous motivational constructs on behavioural persistence. In both studies, implicit autonomous motivation significantly predicted unique variance in time spent on each task. Several explicit measures of autonomous motivation also significantly predicted persistence. Results provide support for the proposed model and the inclusion of implicit measures in research on motivated behaviour. In addition, implicit measures of autonomous motivation appear to be better suited to explaining variance in behaviours that are more spontaneous or unplanned. Future implications for research examining implicit motivation from dual-systems models and SDT approaches are outlined. © 2012 The British Psychological Society.

Developing a New Computer-Aided Clinical Decision Support System for Prediction of Successful Postcardioversion Patients with Persistent Atrial Fibrillation.

PubMed

Sterling, Mark; Huang, David T; Ghoraani, Behnaz

2015-01-01

We propose a new algorithm to predict the outcome of direct-current electric (DCE) cardioversion for atrial fibrillation (AF) patients. AF is the most common cardiac arrhythmia and DCE cardioversion is a noninvasive treatment to end AF and return the patient to sinus rhythm (SR). Unfortunately, there is a high risk of AF recurrence in persistent AF patients; hence clinically it is important to predict the DCE outcome in order to avoid the procedure's side effects. This study develops a feature extraction and classification framework to predict AF recurrence patients from the underlying structure of atrial activity (AA). A multiresolution signal decomposition technique, based on matching pursuit (MP), was used to project the AA over a dictionary of wavelets. Seven novel features were derived from the decompositions and were employed in a quadratic discrimination analysis classification to predict the success of post-DCE cardioversion in 40 patients with persistent AF. The proposed algorithm achieved 100% sensitivity and 95% specificity, indicating that the proposed computational approach captures detailed structural information about the underlying AA and could provide reliable information for effective management of AF.

How to evaluate population management? Transforming the Care Continuum Alliance population health guide toward a broadly applicable analytical framework.

PubMed

Struijs, Jeroen N; Drewes, Hanneke W; Heijink, Richard; Baan, Caroline A

2015-04-01

Many countries face the persistent twin challenge of providing high-quality care while keeping health systems affordable and accessible. As a result, the interest for more efficient strategies to stimulate population health is increasing. A possible successful strategy is population management (PM). PM strives to address health needs for the population at-risk and the chronically ill at all points along the health continuum by integrating services across health care, prevention, social care and welfare. The Care Continuum Alliance (CCA) population health guide, which recently changed their name in Population Health Alliance (PHA) provides a useful instrument for implementing and evaluating such innovative approaches. This framework is developed for PM specifically and describes the core elements of the PM-concept on the basis of six subsequent interrelated steps. The aim of this article is to transform the CCA framework into an analytical framework. Quantitative methods are refined and we operationalized a set of indicators to measure the impact of PM in terms of the Triple Aim (population health, quality of care and cost per capita). Additionally, we added a qualitative part to gain insight into the implementation process of PM. This resulted in a broadly applicable analytical framework based on a mixed-methods approach. In the coming years, the analytical framework will be applied within the Dutch Monitor Population Management to derive transferable 'lessons learned' and to methodologically underpin the concept of PM. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Comparing Future Options for Human Space Flight

NASA Technical Reports Server (NTRS)

Sherwood, Brent

2010-01-01

The paper analyzes the "value proposition" for government-funded human space flight, a vexing question that persistently dogs efforts to justify its $10(exp 10)/year expense in the U.S. The original Mercury/Gemini/Apollo value proposition is not valid today. Neither was it the value proposition actually promoted by von Braun, which the post-Apollo 80% of human space flight history has persistently attempted to fulfill. Divergent potential objectives for human space flight are captured in four strategic options - Explore Mars; accelerate Space Passenger Travel; enable Space Power for Earth; and Settle the Moon - which are then analyzed for their Purpose, societal Myth, Legacy benefits, core Needs, and result as measured by the number and type of humans they would fly in space. This simple framework is proposed as a way to support productive dialogue with public and other stakeholders, to determine a sustainable value proposition for human space flight.

Persistence and breakdown of strand symmetry in the human genome.

PubMed

Zhang, Shang-Hong

2015-04-07

Afreixo, V., Bastos, C.A.C., Garcia, S.P., Rodrigues, J.M.O.S., Pinho, A.J., Ferreira, P.J.S.G., 2013. The breakdown of the word symmetry in the human genome. J. Theor. Biol. 335, 153-159 analyzed the word symmetry (strand symmetry or the second parity rule) in the human genome. They concluded that strand symmetry holds for oligonucleotides up to 6 nt and is no longer statistically significant for oligonucleotides of higher orders. However, although they provided some new results for the issue, their interpretation would not be fully justified. Also, their conclusion needs to be further evaluated. Further analysis of their results, especially those of equivalence tests and word symmetry distance, shows that strand symmetry would persist for higher-order oligonucleotides up to 9 nt in the human genome, at least for its overall frequency framework (oligonucleotide frequency pattern). Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparing future options for human space flight

NASA Astrophysics Data System (ADS)

Sherwood, Brent

2011-09-01

The paper analyzes the "value proposition" for government-funded human space flight, a vexing question that persistently dogs efforts to justify its $10 10/year expense in the US. The original Mercury/Gemini/Apollo value proposition is not valid today. Neither was it the value proposition actually promoted by von Braun, which the post-Apollo 80% of human space flight history has persistently attempted to fulfill. Divergent potential objectives for human space flight are captured in four strategic options— Explore Mars; accelerate Space Passenger Travel; enable Space Power for Earth; and Settle the Moon—which are then analyzed for their purpose, societal myth, legacy benefits, core needs, and result as measured by the number and type of humans they would fly in space. This simple framework is proposed as a way to support productive dialog with public and other stakeholders, to determine a sustainable value proposition for human space flight.

Parasitic causes of prolonged diarrhoea in travellers - diagnosis and management.

PubMed

Slack, Andrew

2012-10-01

Prolonged infectious diarrhoea in the returning traveller is generally caused by protozoal and occasionally by helminth parasites. This article provides a framework for the diagnosis, management and prevention of the diseases that cause persistent diarrhoea in the traveller. A large proportion of disease is caused by Giardia lamblia, Cryptosporidium parvum and Entamoeba histolytica. However, given the ease of travel with comorbid conditions such as human immunodeficiency virus, there is an expanding list of organisms that can cause persistent diarrhoea. An awareness of the likely aetiological agents and their clinical features enables a more effective diagnosis and management of the patient's condition using an appropriate antiparasitic agent. Prevention strategies need to be initiated before travel and should consist of simple but memorable advice. Noninfectious causes of diarrhoea should be considered as diarrhoea can be a prominent feature of conditions such as hyperthyroidism or coeliac disease.

Integrating theory and practice to increase scientific workforce diversity: a framework for career development in graduate research training.

PubMed

Byars-Winston, Angela; Gutierrez, Belinda; Topp, Sharon; Carnes, Molly

2011-01-01

Few, if any, educational interventions intended to increase underrepresented minority (URM) graduate students in biological and behavioral sciences are informed by theory and research on career persistence. Training and Education to Advance Minority Scholars in Science (TEAM-Science) is a program funded by the National Institute of General Medical Sciences at the University of Wisconsin-Madison with the twin goals of increasing the number of URM students entering and completing a PhD in BBS and increasing the number of these students who pursue academic careers. A framework for career development in graduate research training is proposed using social cognitive career theory. Based on this framework, TEAM-Science has five core components: 1) mentor training for the research advisor, 2) eight consensus-derived fundamental competencies required for a successful academic career, 3) career coaching by a senior faculty member, 4) an individualized career development plan that aligns students' activities with the eight fundamental competencies, and 5) a strengths, weaknesses, opportunities, and threats personal career analysis. This paper describes the theoretical framework used to guide development of these components, the research and evaluation plan, and early experience implementing the program. We discuss the potential of this framework to increase desired career outcomes for URM graduate trainees in mentored research programs and, thereby, strengthen the effectiveness of such interventions on participants' career behaviors.

Integrating Theory and Practice to Increase Scientific Workforce Diversity: A Framework for Career Development in Graduate Research Training

PubMed Central

Byars-Winston, Angela; Gutierrez, Belinda; Topp, Sharon; Carnes, Molly

2011-01-01

Few, if any, educational interventions intended to increase underrepresented minority (URM) graduate students in biological and behavioral sciences are informed by theory and research on career persistence. Training and Education to Advance Minority Scholars in Science (TEAM-Science) is a program funded by the National Institute of General Medical Sciences at the University of Wisconsin–Madison with the twin goals of increasing the number of URM students entering and completing a PhD in BBS and increasing the number of these students who pursue academic careers. A framework for career development in graduate research training is proposed using social cognitive career theory. Based on this framework, TEAM-Science has five core components: 1) mentor training for the research advisor, 2) eight consensus-derived fundamental competencies required for a successful academic career, 3) career coaching by a senior faculty member, 4) an individualized career development plan that aligns students’ activities with the eight fundamental competencies, and 5) a strengths, weaknesses, opportunities, and threats personal career analysis. This paper describes the theoretical framework used to guide development of these components, the research and evaluation plan, and early experience implementing the program. We discuss the potential of this framework to increase desired career outcomes for URM graduate trainees in mentored research programs and, thereby, strengthen the effectiveness of such interventions on participants’ career behaviors. PMID:22135370

Framework for Evaluating the Health Impact of the Scale-Up of Malaria Control Interventions on All-Cause Child Mortality in Sub-Saharan Africa

PubMed Central

Yé, Yazoume; Eisele, Thomas P.; Eckert, Erin; Korenromp, Eline; Shah, Jui A.; Hershey, Christine L.; Ivanovich, Elizabeth; Newby, Holly; Carvajal-Velez, Liliana; Lynch, Michael; Komatsu, Ryuichi; Cibulskis, Richard E.; Moore, Zhuzhi; Bhattarai, Achuyt

2017-01-01

Abstract. Concerted efforts from national and international partners have scaled up malaria control interventions, including insecticide-treated nets, indoor residual spraying, diagnostics, prompt and effective treatment of malaria cases, and intermittent preventive treatment during pregnancy in sub-Saharan Africa (SSA). This scale-up warrants an assessment of its health impact to guide future efforts and investments; however, measuring malaria-specific mortality and the overall impact of malaria control interventions remains challenging. In 2007, Roll Back Malaria's Monitoring and Evaluation Reference Group proposed a theoretical framework for evaluating the impact of full-coverage malaria control interventions on morbidity and mortality in high-burden SSA countries. Recently, several evaluations have contributed new ideas and lessons to strengthen this plausibility design. This paper harnesses that new evaluation experience to expand the framework, with additional features, such as stratification, to examine subgroups most likely to experience improvement if control programs are working; the use of a national platform framework; and analysis of complete birth histories from national household surveys. The refined framework has shown that, despite persisting data challenges, combining multiple sources of data, considering potential contributions from both fundamental and proximate contextual factors, and conducting subnational analyses allows identification of the plausible contributions of malaria control interventions on malaria morbidity and mortality. PMID:28990923

Sociological Perspectives on College Women's Pathways to Persistence in Physics

NASA Astrophysics Data System (ADS)

Perez-Felkner, Lara

2014-03-01

While there have been notable gains made by some STEM disciplines in closing the gender gap, physics is among the few fields where gender disparities persist. Drawing on both original and secondary data analyses, the speaker will explain how background characteristics and school environments shape persistence on the track to careers in physics and related majors (e.g., engineering and computer science). Recent sociological findings will be emphasized, with particular attention to the speaker's current and published findings from nationally-representative U.S. cohorts and case studies from U.S. high schools and universities, Cambodian universities, and cross-national comparisons. Using a longitudinal framework, the speaker will discuss potential interventions to keep women on the path to physics degrees through secondary school, the transition to college, and undergraduate study. The presentation will additionally discuss how students' racial/ethnic and socioeconomic status and university type influence variation in the scope of gender disparities in entry to scientific career fields, of particular note as the demographics of the undergraduate population and the labor force become increasingly diverse and increasingly less dependent on training within traditional four-year institutions. Emerging evidence across these types of data indicate that the persistent sex segregation in physics is not attributable to biological nor academic factors; rather, these traditional explanations consistently fail to explain the gap. The presentation will conclude with a discussion of potential interventions that faculty, institutions, and the field can draw upon to promote women's persistence in physics degrees and careers. This material is based upon work supported by the National Science Foundation under Grants Nos. 0129365 and 0815295, and a grant from the American Educational Research Association, under NSF Grant No. DRL-0941014, and the Pathways to Adulthood Program.

Advanced subsidence monitoring using persistent scatterer interferometry for Jharia Coal Field, Dhanbad, India

NASA Astrophysics Data System (ADS)

Thapa, Shailaja; Chatterjee, R. S.; Kumar, Dheeraj; Singh, K. B.; Sengar, Vivek

2017-10-01

This paper presents a spatiotemporal study of surface subsidence over urban area due to coal mining using Persistent scatterer interferometry. In the past few years Differential Interferometric Synthetic Aperture Radar has emerged as a very useful remote sensing technique for measuring land subsidence. It plays a vital role in insitu subsidence prediction of coal mining area. However there are some limitation viz. atmospheric decorrelation, temporal decorrelation and spatial decorrelation with conventional D-InSAR techniques, which can be overcome up to certain extent by using multiinterferogram framework approach. The Persistent Scatterer interferometry technique comprises of more number of SAR datasets, it only concentrates over the pixel which remain coherent over long time period. Persistent Scatterer interferometry makes deformation measurement on permanent scattering location for the targeted ground surface. Mainly, these permanent scatterer are manmade features like metallic bridges, dams, antennae roof of buildings etc. apart that some permanent scatterer may comprise of prominent stable natural targets. The results obtained from PS-InSAR gives more precised measurement of surface deformation. Total eight ALOS PALSAR scenes covering the time period from 2007 to 2010 have been utilized to produce ground deformation map using PSInSAR techniques for Jharia Coal field, Dhanbad. This is proven technique, which helps to identify the persistent land surface movement .The results were analyzed Sijua area in Jharia coalfield. The subsidence fringes were demarcated over the entire study area. The PSInSAR results were validated using precision leveling data provided by mining authorities. The results demonstrates that PSInSAR can be used as potential tool to highlight the subsidence prone area depending upon the spatial and temporal coherency of SAR data.

Understanding the Spatial and Temporal Variations in Hormone Transport within the Stream Ecosystem

NASA Astrophysics Data System (ADS)

Mallakpour, I.; Ward, A. S.; Basu, N. B.

2012-12-01

Agricultural, urban, and industrial activities, including land application of manures and discharge of municipal and industrial wastewater, act as point and nonpoint sources for steroid hormones in soils, water, and sediments. Hormones are endocrine disruptors, and their occurrence in stream ecosystems has been implicated in the decline of certain species and change of sex in fish. Laboratory studies indicate that steroid hormones tend to have moderately large sorption coefficients and relatively short half-lives, from a few hours to a few days, suggesting that their persistence and subsequent leaching from soils will be limited. However, these chemicals continue to be detected in streams, indicating that laboratory studies may not capture the coupled hydrologic and biogeochemical dynamics occurring at the field or stream-reach scale. Understanding the spatial and temporal persistence of these chemicals downstream of a confined animal feeding operation (CAFO) or wastewater treatment plant (WWTP) requires a coupled hydrologic and biogeochemical model that takes into account multiple interacting species, sediment processes, and different aerobic and anaerobic reaction pathways and rates. In this study, we focus on two hormones, estrone (E1) and 17β-estradiol (E2), with redox dynamics controlling the conversion between E1 and E2. A 1D stream-reach model with a main-channel and a hyporheic zone was developed similar to the commonly used OTIS model. Processes such as photolysis, decay, and sorption to sediments were included in the model framework. The inclusion of coupled reactions, with specific reaction rates and pathways driven by different reaction pathway, that in turn can be dynamic during a storm event (for example, increasing discharge might lead to more aerobic conditions), was the novelty of the approach. The modeling framework was then used to quantify the relative importance of the different reaction pathways under varying flow conditions, and evaluate the persistence of these chemicals as a function of hydrologic and biogeochemical controls.

Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission

PubMed Central

2014-01-01

Background Dengue is a disease that has undergone significant expansion over the past hundred years. Understanding what factors limit the distribution of transmission can be used to predict current and future limits to further dengue expansion. While not the only factor, temperature plays an important role in defining these limits. Previous attempts to analyse the effect of temperature on the geographic distribution of dengue have not considered its dynamic intra-annual and diurnal change and its cumulative effects on mosquito and virus populations. Methods Here we expand an existing modelling framework with new temperature-based relationships to model an index proportional to the basic reproductive number of the dengue virus. This model framework is combined with high spatial and temporal resolution global temperature data to model the effects of temperature on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission. Results Our model predicted areas where temperature is not expected to permit transmission and/or Aedes persistence throughout the year. By reanalysing existing experimental data our analysis indicates that Ae. albopictus, often considered a minor vector of dengue, has comparable rates of virus dissemination to its primary vector, Ae. aegypti, and when the longer lifespan of Ae. albopictus is considered its competence for dengue virus transmission far exceeds that of Ae. aegypti. Conclusions These results can be used to analyse the effects of temperature and other contributing factors on the expansion of dengue or its Aedes vectors. Our finding that Ae. albopictus has a greater capacity for dengue transmission than Ae. aegypti is contrary to current explanations for the comparative rarity of dengue transmission in established Ae. albopictus populations. This suggests that the limited capacity of Ae. albopictus to transmit DENV is more dependent on its ecology than vector competence. The recommendations, which we explicitly outlined here, point to clear targets for entomological investigation. PMID:25052008

Chronological framework for the deglaciation of the Lake Michigan lobe of the Laurentide ice sheet from ice-walled lake deposits

USGS Publications Warehouse

Curry, B.; Petras, J.

2011-01-01

A revised chronological framework for the deglaciation of the Lake Michigan lobe of the south-central Laurentide Ice Sheet is presented based on radiocarbon ages of plant macrofossils archived in the sediments of low-relief ice-walled lakes. We analyze the precision and accuracy of 15 AMS 14C ages of plant macrofossils obtained from a single ice-walled lake deposit. The semi-circular basin is about 0.72km wide and formed of a 4- to 16-m-thick succession of loess and lacustrine sediment inset into till. The assayed material was leaves, buds and stems of Salix herbacea (snowbed willow). The pooled mean of three ages from the basal lag facies was 18 270??50 14C a BP (21 810cal. a BP), an age that approximates the switch from active ice to stagnating conditions. The pooled mean of four ages for the youngest fossil-bearing horizon was 17 770??40 14C a BP (21 180cal. a BP). Material yielding the oldest and youngest ages may be obtained from sediment cores located at any place within the landform. Based on the estimated settling times of overlying barren, rhythmically bedded sand and silt, the lacustrine environment persisted for about 50 more years. At a 67% confidence level, the dated part of the ice-walled lake succession persisted for between 210 and 860cal. a (modal value: 610cal. a). The deglacial age of five moraines or morainal complexes formed by the fluctuating margin of the Lake Michigan lobe have been assessed using this method. There is no overlap of time intervals documenting when ice-walled lakes persisted on these landforms. The rapid readvances of the lobe during deglaciation after the last glacial maximum probably occurred at some point between the periods of ice-walled lake sedimentation. ?? 2011 John Wiley & Sons, Ltd.

Incorporating Dispositional Traits into the Treatment of Anorexia Nervosa

PubMed Central

Herzog, David; Moskovich, Ashley; Merwin, Rhonda; Lin, Tammy

2014-01-01

We provide a general framework to guide the development of interventions that aim to address persistent features in eating disorders that may preclude effective treatment. Using perfectionism as an exemplar, we draw from research in cognitive neuroscience regarding attention and reinforcement learning, from learning theory and social psychology regarding vicarious learning and implications for the role modeling of significant others, and from clinical psychology on the importance of verbal narratives as barriers that may influence expectations and shape reinforcement schedules. PMID:21243482

The spectrum of persistent volcanic flank instability: A review and proposed framework based on Kīlauea, Piton de la Fournaise, and Etna

USGS Publications Warehouse

Poland, Michael; Peltier, Aline; Bonaforte, Alessandro; Puglisi, Giuseppe

2017-01-01

Persistent motion of the south flank of Kīlauea Volcano, Hawai'i, has been known for several decades, but has only recently been identified at other large basaltic volcanoes—namely Piton de la Fournaise (La Réunion) and Etna (Sicily)—thanks to the advent of space geodetic techniques. Nevertheless, understanding of long-term flank instability is based largely on the example of Kīlauea, despite the large differences in the manifestations and mechanisms of the process when viewed through a comparative lens. For example, the rate of flank motion at Kīlauea is several times that of Etna and Piton de la Fournaise and is accommodated on a slip plane several km deeper than is probably present at the other two volcanoes. Gravitational spreading also appears to be the dominant driving force at Kīlauea, given the long-term steady motion of the volcano's south flank regardless of eruptive/intrusive activity, whereas magmatic activity plays a larger role in flank deformation at Etna and Piton de la Fournaise. Kīlauea and Etna, however, are both characterized by heavily faulted flanks, while Piton de la Fournaise shows little evidence for flank faulting. A helpful means of understanding the spectrum of persistent flank motion at large basaltic edifices may be through a framework defined on one hand by magmatic activity (which encompasses both magma supply and edifice size), and on the other hand by the structural setting of the volcano (especially the characteristics of the subvolcanic basement or subhorizontal intravolcanic weak zones). A volcano's size and magmatic activity will dictate the extent to which gravitational and magmatic forces can drive motion of an unstable flank (and possibly the level of faulting of that flank), while the volcano's structural setting governs whether or not a plane of weakness exists beneath or within the edifice and can facilitate flank slip. Considering persistent flank instability using this conceptual model is an alternative to using a single volcano as a “type example”—especially given that the example is usually Kīlauea, which defines an extreme end of the spectrum—and can provide a basis for understanding why flank motion may or may not exist on other large basaltic volcanoes worldwide.

The spectrum of persistent volcanic flank instability: A review and proposed framework based on Kīlauea, Piton de la Fournaise, and Etna

NASA Astrophysics Data System (ADS)

Poland, Michael P.; Peltier, Aline; Bonforte, Alessandro; Puglisi, Giuseppe

2017-06-01

Persistent motion of the south flank of Kīlauea Volcano, Hawai'i, has been known for several decades, but has only recently been identified at other large basaltic volcanoes-namely Piton de la Fournaise (La Réunion) and Etna (Sicily)-thanks to the advent of space geodetic techniques. Nevertheless, understanding of long-term flank instability is based largely on the example of Kīlauea, despite the large differences in the manifestations and mechanisms of the process when viewed through a comparative lens. For example, the rate of flank motion at Kīlauea is several times that of Etna and Piton de la Fournaise and is accommodated on a slip plane several km deeper than is probably present at the other two volcanoes. Gravitational spreading also appears to be the dominant driving force at Kīlauea, given the long-term steady motion of the volcano's south flank regardless of eruptive/intrusive activity, whereas magmatic activity plays a larger role in flank deformation at Etna and Piton de la Fournaise. Kīlauea and Etna, however, are both characterized by heavily faulted flanks, while Piton de la Fournaise shows little evidence for flank faulting. A helpful means of understanding the spectrum of persistent flank motion at large basaltic edifices may be through a framework defined on one hand by magmatic activity (which encompasses both magma supply and edifice size), and on the other hand by the structural setting of the volcano (especially the characteristics of the subvolcanic basement or subhorizontal intravolcanic weak zones). A volcano's size and magmatic activity will dictate the extent to which gravitational and magmatic forces can drive motion of an unstable flank (and possibly the level of faulting of that flank), while the volcano's structural setting governs whether or not a plane of weakness exists beneath or within the edifice and can facilitate flank slip. Considering persistent flank instability using this conceptual model is an alternative to using a single volcano as a "type example"-especially given that the example is usually Kīlauea, which defines an extreme end of the spectrum-and can provide a basis for understanding why flank motion may or may not exist on other large basaltic volcanoes worldwide.

Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?

PubMed Central

Heilig, M.; Egli, M.; Crabbe, J.C.; Becker, H.C.

2012-01-01

The role of withdrawal-related phenomena in development and maintenance of alcohol addiction remains under debate. A “self-medication” framework postulates that emotional changes are induced by a history of alcohol use, persist into abstinence, and are a major factor in maintaining alcoholism. This view initially focused on negative emotional states during early withdrawal: these are pronounced, occur in the vast majority of alcohol dependent patients, and are characterized by depressed mood and elevated anxiety. This concept lost popularity with the realization that, in most patients, these symptoms abate over 3 – 6 weeks of abstinence, while relapse risk persists long beyond this period. More recently, animal data have established that a prolonged history of alcohol dependence induces more subtle neuroadaptations. These confer altered emotional processing that persists long into protracted abstinence. The resulting behavioral phenotype is characterized by excessive voluntary alcohol intake and increased behavioral sensitivity to stress. Emerging human data support the clinical relevance of negative emotionality for protracted abstinence and relapse. These developments prompt a series of research questions: 1) Are processes observed during acute withdrawal, while transient in nature, mechanistically related to those that remain during protracted abstinence? 2) Is susceptibility to negative emotionality in acute withdrawal in part due to heritable factors, similar to what animal models have indicated for susceptibility to physical aspects of withdrawal? 3) To what extent is susceptibility to negative affect that persists into protracted abstinence heritable? PMID:20148778

Altered morphology of the nucleus accumbens in persistent developmental stuttering.

PubMed

Neef, Nicole E; Bütfering, Christoph; Auer, Tibor; Metzger, F Luise; Euler, Harald A; Frahm, Jens; Paulus, Walter; Sommer, Martin

2018-03-01

Neuroimaging studies in persistent developmental stuttering repeatedly report altered basal ganglia functions. Together with thalamus and cerebellum, these structures mediate sensorimotor functions and thus represent a plausible link between stuttering and neuroanatomy. However, stuttering is a complex, multifactorial disorder. Besides sensorimotor functions, emotional and social-motivational factors constitute major aspects of the disorder. Here, we investigated cortical and subcortical gray matter regions to study whether persistent developmental stuttering is also linked to alterations of limbic structures. The study included 33 right-handed participants who stutter and 34 right-handed control participants matched for sex, age, and education. Structural images were acquired using magnetic resonance imaging to estimate volumetric characteristics of the nucleus accumbens, hippocampus, amygdala, pallidum, putamen, caudate nucleus, and thalamus. Volumetric comparisons and vertex-based shape comparisons revealed structural differences. The right nucleus accumbens was larger in participants who stutter compared to controls. Recent theories of basal ganglia functions suggest that the nucleus accumbens is a motivation-to-movement interface. A speaker intends to reach communicative goals, but stuttering can derail these efforts. It is therefore highly plausible to find alterations in the motivation-to-movement interface in stuttering. While behavioral studies of stuttering sought to find links between the limbic and sensorimotor system, we provide the first neuroimaging evidence of alterations in the limbic system. Thus, our findings might initialize a unified neurobiological framework of persistent developmental stuttering that integrates sensorimotor and social-motivational neuroanatomical circuitries. Copyright © 2017 Elsevier Inc. All rights reserved.

Sustainability. Planetary boundaries: guiding human development on a changing planet.

PubMed

Steffen, Will; Richardson, Katherine; Rockström, Johan; Cornell, Sarah E; Fetzer, Ingo; Bennett, Elena M; Biggs, Reinette; Carpenter, Stephen R; de Vries, Wim; de Wit, Cynthia A; Folke, Carl; Gerten, Dieter; Heinke, Jens; Mace, Georgina M; Persson, Linn M; Ramanathan, Veerabhadran; Reyers, Belinda; Sörlin, Sverker

2015-02-13

The planetary boundaries framework defines a safe operating space for humanity based on the intrinsic biophysical processes that regulate the stability of the Earth system. Here, we revise and update the planetary boundary framework, with a focus on the underpinning biophysical science, based on targeted input from expert research communities and on more general scientific advances over the past 5 years. Several of the boundaries now have a two-tier approach, reflecting the importance of cross-scale interactions and the regional-level heterogeneity of the processes that underpin the boundaries. Two core boundaries—climate change and biosphere integrity—have been identified, each of which has the potential on its own to drive the Earth system into a new state should they be substantially and persistently transgressed. Copyright © 2015, American Association for the Advancement of Science.

Design of material management system of mining group based on Hadoop

NASA Astrophysics Data System (ADS)

Xia, Zhiyuan; Tan, Zhuoying; Qi, Kuan; Li, Wen

2018-01-01

Under the background of persistent slowdown in mining market at present, improving the management level in mining group has become the key link to improve the economic benefit of the mine. According to the practical material management in mining group, three core components of Hadoop are applied: distributed file system HDFS, distributed computing framework Map/Reduce and distributed database HBase. Material management system of mining group based on Hadoop is constructed with the three core components of Hadoop and SSH framework technology. This system was found to strengthen collaboration between mining group and affiliated companies, and then the problems such as inefficient management, server pressure, hardware equipment performance deficiencies that exist in traditional mining material-management system are solved, and then mining group materials management is optimized, the cost of mining management is saved, the enterprise profit is increased.

Abstinence education for urban youth.

PubMed

Carter-Jessop, L; Franklin, L N; Heath, J W; Jimenez-Irizarry, G; Peace, M D

2000-08-01

Teen sexual problems in the U.S. are reaching enormous proportions. Attempts to prevent common problems, pregnancy and sexually transmitted diseases, are underway through the persistent efforts of community, health, academic and government organizations. Abstinence education is one of the current attempts. However, the lack of well defined theoretical frameworks and analyses of outcomes have limited progress in the study of abstinence education. This article describes a pilot program in abstinence-only education provided to six groups of young teens within an urban middle school. The framework for the program, cognitive social learning theory, is described and operationalized. Student pretest-posttest attitudes, open-ended written comments about the program and the researchers' anecdotes about behavioral changes in the students are the outcome measures. Positive attitudes about premarital abstinence increased for all six groups; for four of the six groups the increase was statistically significant.

A structural-phenomenological typology of mind-matter correlations.

PubMed

Atmanspacher, Harald; Fach, Wolfgang

2013-04-01

We present a typology of mind-matter correlations embedded in a dual-aspect monist framework as proposed by Pauli and Jung. They conjectured a picture in which the mental and the material arise as two complementary aspects of one underlying psychophysically neutral reality to which they cannot be reduced and to which direct empirical access is impossible. This picture suggests structural, persistent, reproducible mind-matter correlations by splitting the underlying reality into aspects. In addition, it suggests induced, occasional, evasive mind-matter correlations above and below, respectively, those stable baseline correlations. Two significant roles for the concept of meaning in this framework are elucidated. Finally, it is shown that the obtained typology is in perfect agreement with an empirically based classification of the phenomenology of mind-matter correlations as observed in exceptional human experiences. © 2013, The Society of Analytical Psychology.

Science Misconceptions and Funds of Knowledge: Impact on STEM Choices

NASA Astrophysics Data System (ADS)

Millham, R. A.

2015-12-01

Alternate conceptions (misconceptions) in science can hinder understandings and impact student growth and comfort level in the science classroom. Resarch has, and still does, demonstrate that science misconceptions are still prevelant in many conceptual frameworks. Although breaking down misconceptions to rebuild scientifically sound conceptual frameworks are practices used in many science classrooms, misconceptions still persist. After identifying specific misconceptions, we asked our participating teachers to conduct specific instructional interventions in an effort to mitigate misconceptions and bring about scientific understandings with excellent results overall. However, important factors also need condsideration: funds of knowledge and the abilty to determine the differnce between understandings and beliefs held by an individual. This abstract deals with what has been determined in the research conducted by the author, and the next steps to better understandings about how to mitigate alternate conceptions.

Early stage structural development of prototypical zeolitic imidazolate framework (ZIF) in solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terban, Maxwell W.; Banerjee, Debasis; Ghose, Sanjit

Given the wide-ranging potential applications of metal organic frameworks (MOFs), an emerging imperative is to understand their formation with atomic scale precision. This will aid in designing syntheses for next-generation MOFs with enhanced properties and functionalities. Major challenges are to characterize the early-stage seeds, and the pathways to framework growth, which require synthesis coupled with in situ structural characterization sensitive to nanoscale structures in solution. Here we report measurements of an in situ synthesis of a prototypical MOF, ZIF-8, utilizing synchrotron X-ray atomic pair distribution function (PDF) analysis optimized for sensitivity to dilute species, complemented by mass spectrometry, electron microscopy,more » and density functional theory calculations. We observe that despite rapid formation of the crystalline product, a high concentration of Zn(2-MeIm) 4(2-MeIm=2-methylimidazolate) initially forms and persists as stable clusters over long times. A secondary, amorphous phase also pervades during the synthesis, which has a structural similarity to the final ZIF-8 and may act as an intermediate to the final product.« less

A framework convention on global health: health for all, justice for all.

PubMed

Gostin, Lawrence O

2012-05-16

Health inequalities represent perhaps the most consequential global health challenge and yet they persist despite increased funding and innovative programs. The United Nations is revising the Millennium Development Goals (MDGs) that will shape the world for many years to come. What would a transformative post-MDG framework for global health justice look like? A global coalition of civil society and academics--the Joint Action and Learning Initiative on National and Global Responsibilities for Health (JALI)--has formed an international campaign to advocate for a Framework Convention on Global Health (FCGH). Recently endorsed by the UN Secretary-General, the FCGH would reimagine global governance for health, offering a new post-MDG vision. This Special Communication describes the key modalities of an FCGH to illustrate how it would improve health and reduce inequalities. The modalities would include defining national responsibilities for the population's health; defining international responsibilities for reliable, sustainable funding; setting global health priorities; coordinating fragmented activities; reshaping global governance for health; and providing strong global health leadership through the World Health Organization.

Resilience and sustainability: Similarities and differences in environmental management applications.

PubMed

Marchese, Dayton; Reynolds, Erin; Bates, Matthew E; Morgan, Heather; Clark, Susan Spierre; Linkov, Igor

2018-02-01

In recent years there have been many disparate uses of the terms sustainability and resilience, with some framing sustainability and resilience as the same concept, and others claiming them to be entirely different and unrelated. To investigate similarities, differences, and current management frameworks for increasing sustainability and resilience, a literature review was undertaken that focused on integrated use of sustainability and resilience in an environmental management context. Sustainability was defined through the triple bottom line of environmental, social and economic system considerations. Resilience was viewed as the ability of a system to prepare for threats, absorb impacts, recover and adapt following persistent stress or a disruptive event. Three generalized management frameworks for organizing sustainability and resilience were found to dominate the literature: (1) resilience as a component of sustainability, (2) sustainability as a component of resilience, and (3) resilience and sustainability as separate objectives. Implementations of these frameworks were found to have common goals of providing benefits to people and the environment under normal and extreme operating conditions, with the best examples building on similarities and minimizing conflicts between resilience and sustainability. Published by Elsevier B.V.

Early stage structural development of prototypical zeolitic imidazolate framework (ZIF) in solution

DOE PAGES

Terban, Maxwell W.; Banerjee, Debasis; Ghose, Sanjit; ...

2018-02-05

Given the wide-ranging potential applications of metal organic frameworks (MOFs), an emerging imperative is to understand their formation with atomic scale precision. This will aid in designing syntheses for next-generation MOFs with enhanced properties and functionalities. Major challenges are to characterize the early-stage seeds, and the pathways to framework growth, which require synthesis coupled with in situ structural characterization sensitive to nanoscale structures in solution. Here we report measurements of an in situ synthesis of a prototypical MOF, ZIF-8, utilizing synchrotron X-ray atomic pair distribution function (PDF) analysis optimized for sensitivity to dilute species, complemented by mass spectrometry, electron microscopy,more » and density functional theory calculations. We observe that despite rapid formation of the crystalline product, a high concentration of Zn(2-MeIm) 4(2-MeIm=2-methylimidazolate) initially forms and persists as stable clusters over long times. A secondary, amorphous phase also pervades during the synthesis, which has a structural similarity to the final ZIF-8 and may act as an intermediate to the final product.« less

Enhancement of antibiotic productions by engineered nitrate utilization in actinomycetes.

PubMed

Meng, Sitong; Wu, Hang; Wang, Lei; Zhang, Buchang; Bai, Linquan

2017-07-01

Nitrate is necessary for primary and secondary metabolism of actinomycetes and stimulates the production of a few antibiotics, such as lincomycin and rifamycin. However, the mechanism of this nitrate-stimulating effect was not fully understood. Two putative ABC-type nitrate transporters were identified in Streptomyces lincolnensis NRRL2936 and verified to be involved in lincomycin biosynthesis. With nitrate supplementation, the transcription of nitrogen assimilation genes, nitrate-specific ABC1 transporter genes, and lincomycin exporter gene lmrA was found to be enhanced and positively regulated by the global regulator GlnR, whose expression was also improved. Moreover, heterologous expression of ABC2 transporter genes in Streptomyces coelicolor M145 resulted in an increased actinorhodin production. Further incorporation of a nitrite-specific transporter gene nirC, as in nirC-ABC2 cassette, led to an even higher actinorhodin production. Similarly, the titers of salinomycin, ansamitocin, lincomycin, and geldanamycin were increased with the integration of this cassette to Streptomyces albus BK3-25, Actinosynnema pretiosum ATCC31280, S. lincolnensis LC-G, and Streptomyces hygroscopicus XM201, respectively. Our work expanded the nitrate-stimulating effect to many antibiotic producers by utilizing the nirC-ABC2 cassette for enhanced nitrate utilization, which could become a general tool for titer increase of antibiotics in actinomycetes.

A Conceptual Framework for Planning Systemic Human Adaptation to Global Warming

PubMed Central

Tait, Peter W.; Hanna, Elizabeth G.

2015-01-01

Human activity is having multiple, inter-related effects on ecosystems. Greenhouse gas emissions persisting along current trajectories threaten to significantly alter human society. At 0.85 °C of anthropogenic warming, deleterious human impacts are acutely evident. Additional warming of 0.5 °C–1.0 °C from already emitted CO2 will further intensify extreme heat and damaging storm events. Failing to sufficiently address this trend will have a heavy human toll directly and indirectly on health. Along with mitigation efforts, societal adaptation to a warmer world is imperative. Adaptation efforts need to be significantly upscaled to prepare society to lessen the public health effects of rising temperatures. Modifying societal behaviour is inherently complex and presents a major policy challenge. We propose a social systems framework for conceptualizing adaptation that maps out three domains within the adaptation policy landscape: acclimatisation, behavioural adaptation and technological adaptation, which operate at societal and personal levels. We propose that overlaying this framework on a systems approach to societal change planning methods will enhance governments’ capacity and efficacy in strategic planning for adaptation. This conceptual framework provides a policy oriented planning assessment tool that will help planners match interventions to the behaviours being targeted for change. We provide illustrative examples to demonstrate the framework’s application as a planning tool. PMID:26334285

Exploring Nurse Leaders' Policy Participation Within the Context of a Nursing Conceptual Framework.

PubMed

Waddell, Ashley; Adams, Jeffrey M; Fawcett, Jacqueline

2017-11-01

This study was designed to describe and quantify the experiences of nurse leaders working to influence policy and to build consensus for priority skills and knowledge useful in policy efforts within the context of a nursing conceptual framework. The conceptual model for nursing and health policy and the Adams influence model were combined into a conceptual framework used to guide this two-round modified Delphi study. Twenty-two nurse leaders who were members of a state action coalition participated in the Round 1 focus group; 15 of these leaders completed the Round 2 electronic survey. Round 1 themes indicated the value of a passion for policy, the importance of clear communication, and an understanding the who and when of policy work. Round 2 data reinforced the importance of clear communication regarding policy engagement; knowing the who and when of policy closely followed, and having a passion for policy work was identified as least important. These themes inform learning objectives for nursing education and preparation for interactions with public officials because influencing policy requires knowledge, skills, and persistence. Study findings begin to describe how nurse leaders influence policy within the context of a nursing conceptual framework and generate implications for research, education, and professional practice.

Design, implementation and validation of a novel open framework for agile development of mobile health applications.

PubMed

Banos, Oresti; Villalonga, Claudia; Garcia, Rafael; Saez, Alejandro; Damas, Miguel; Holgado-Terriza, Juan A; Lee, Sungyong; Pomares, Hector; Rojas, Ignacio

2015-01-01

The delivery of healthcare services has experienced tremendous changes during the last years. Mobile health or mHealth is a key engine of advance in the forefront of this revolution. Although there exists a growing development of mobile health applications, there is a lack of tools specifically devised for their implementation. This work presents mHealthDroid, an open source Android implementation of a mHealth Framework designed to facilitate the rapid and easy development of mHealth and biomedical apps. The framework is particularly planned to leverage the potential of mobile devices such as smartphones or tablets, wearable sensors and portable biomedical systems. These devices are increasingly used for the monitoring and delivery of personal health care and wellbeing. The framework implements several functionalities to support resource and communication abstraction, biomedical data acquisition, health knowledge extraction, persistent data storage, adaptive visualization, system management and value-added services such as intelligent alerts, recommendations and guidelines. An exemplary application is also presented along this work to demonstrate the potential of mHealthDroid. This app is used to investigate on the analysis of human behavior, which is considered to be one of the most prominent areas in mHealth. An accurate activity recognition model is developed and successfully validated in both offline and online conditions.

Executor Framework for DIRAC

NASA Astrophysics Data System (ADS)

Casajus Ramo, A.; Graciani Diaz, R.

2012-12-01

DIRAC framework for distributed computing has been designed as a group of collaborating components, agents and servers, with persistent database back-end. Components communicate with each other using DISET, an in-house protocol that provides Remote Procedure Call (RPC) and file transfer capabilities. This approach has provided DIRAC with a modular and stable design by enforcing stable interfaces across releases. But it made complicated to scale further with commodity hardware. To further scale DIRAC, components needed to send more queries between them. Using RPC to do so requires a lot of processing power just to handle the secure handshake required to establish the connection. DISET now provides a way to keep stable connections and send and receive queries between components. Only one handshake is required to send and receive any number of queries. Using this new communication mechanism DIRAC now provides a new type of component called Executor. Executors process any task (such as resolving the input data of a job) sent to them by a task dispatcher. This task dispatcher takes care of persisting the state of the tasks to the storage backend and distributing them among all the Executors based on the requirements of each task. In case of a high load, several Executors can be started to process the extra load and stop them once the tasks have been processed. This new approach of handling tasks in DIRAC makes Executors easy to replace and replicate, thus enabling DIRAC to further scale beyond the current approach based on polling agents.

Millennium development goal four and child health inequities in indonesia: a systematic review of the literature.

PubMed

Schröders, Julia; Wall, Stig; Kusnanto, Hari; Ng, Nawi

2015-01-01

Millennium Development Goal (MDG) 4 calls for reducing mortality of children under-five years by two-thirds by 2015. Indonesia is on track to officially meet the MDG 4 targets by 2015 but progress has been far from universal. It has been argued that national level statistics, on which MDG 4 relies, obscure persistent health inequities within the country. Particularly inequities in child health are a major global public health challenge both for achieving MDG 4 in 2015 and beyond. This review aims to map out the situation of MDG 4 with respect to disadvantaged populations in Indonesia applying the Social Determinants of Health (SDH) framework. The specific objectives are to answer: Who are the disadvantaged populations? Where do they live? And why and how is the inequitable distribution of health explained in terms of the SDH framework? We retrieved studies through a systematic review of peer-reviewed and gray literature published in 1995-2014. The PRISMA-Equity 2012 statement was adapted to guide the methods of this review. The dependent variables were MDG 4-related indicators; the independent variable "disadvantaged populations" was defined by different categories of social differentiation using PROGRESS. Included texts were analyzed following the guidelines for deductive content analysis operationalized on the basis of the SDH framework. We identified 83 studies establishing evidence on more than 40 different determinants hindering an equitable distribution of child health in Indonesia. The most prominent determinants arise from the shortcomings within the rural health care system, the repercussions of food poverty coupled with low health literacy among parents, the impact of low household decision-making power of mothers, and the consequences of high persistent use of traditional birth attendants among ethnic minorities. This review calls for enhanced understanding of the determinants and pathways that create, detain, and overcome inequities in child health in resource constraint settings like Indonesia and the promotion of actionable health policy recommendations and tailored investments.

Millennium Development Goal Four and Child Health Inequities in Indonesia: A Systematic Review of the Literature

PubMed Central

Schröders, Julia; Wall, Stig; Kusnanto, Hari; Ng, Nawi

2015-01-01

Introduction Millennium Development Goal (MDG) 4 calls for reducing mortality of children under-five years by two-thirds by 2015. Indonesia is on track to officially meet the MDG 4 targets by 2015 but progress has been far from universal. It has been argued that national level statistics, on which MDG 4 relies, obscure persistent health inequities within the country. Particularly inequities in child health are a major global public health challenge both for achieving MDG 4 in 2015 and beyond. This review aims to map out the situation of MDG 4 with respect to disadvantaged populations in Indonesia applying the Social Determinants of Health (SDH) framework. The specific objectives are to answer: Who are the disadvantaged populations? Where do they live? And why and how is the inequitable distribution of health explained in terms of the SDH framework? Methods and Findings We retrieved studies through a systematic review of peer-reviewed and gray literature published in 1995-2014. The PRISMA-Equity 2012 statement was adapted to guide the methods of this review. The dependent variables were MDG 4-related indicators; the independent variable “disadvantaged populations” was defined by different categories of social differentiation using PROGRESS. Included texts were analyzed following the guidelines for deductive content analysis operationalized on the basis of the SDH framework. We identified 83 studies establishing evidence on more than 40 different determinants hindering an equitable distribution of child health in Indonesia. The most prominent determinants arise from the shortcomings within the rural health care system, the repercussions of food poverty coupled with low health literacy among parents, the impact of low household decision-making power of mothers, and the consequences of high persistent use of traditional birth attendants among ethnic minorities. Conclusion This review calls for enhanced understanding of the determinants and pathways that create, detain, and overcome inequities in child health in resource constraint settings like Indonesia and the promotion of actionable health policy recommendations and tailored investments. PMID:25942491

Estimating the effect of the reorganization of interactions on the adaptability of species to changing environments.

PubMed

Cenci, Simone; Montero-Castaño, Ana; Saavedra, Serguei

2018-01-21

A major challenge in community ecology is to understand how species respond to environmental changes. Previous studies have shown that the reorganization of interactions among co-occurring species can modulate their chances to adapt to novel environmental conditions. Moreover, empirical evidence has shown that these ecological dynamics typically facilitate the persistence of groups of species rather than entire communities. However, so far, we have no systematic methodology to identify those groups of species with the highest or lowest chances to adapt to new environments through a reorganization of their interactions. Yet, this could prove extremely valuable for developing new conservation strategies. Here, we introduce a theoretical framework to estimate the effect of the reorganization of interactions on the adaptability of a group of species, within a community, to novel environmental conditions. We introduce the concept of the adaptation space of a group of species based on a feasibility analysis of a population dynamics model. We define the adaptation space of a group as the set of environmental conditions that can be made compatible with its persistence thorough the reorganization of interactions among species within the group. The larger the adaptation space of a group, the larger its likelihood to adapt to a novel environment. We show that the interactions in the community outside a group can act as structural constraints and be used to quantitatively compare the size of the adaptation space among different groups of species within a community. To test our theoretical framework, we perform a data analysis on several pairs of natural and artificially perturbed ecological communities. Overall, we find that the groups of species present in both control and perturbed communities are among the ones with the largest adaptation space. We believe that the results derived from our framework point out towards new directions to understand and estimate the adaptability of species to changing environments. Copyright © 2017 Elsevier Ltd. All rights reserved.

A lightweight messaging-based distributed processing and workflow execution framework for real-time and big data analysis

NASA Astrophysics Data System (ADS)

Laban, Shaban; El-Desouky, Aly

2014-05-01

To achieve a rapid, simple and reliable parallel processing of different types of tasks and big data processing on any compute cluster, a lightweight messaging-based distributed applications processing and workflow execution framework model is proposed. The framework is based on Apache ActiveMQ and Simple (or Streaming) Text Oriented Message Protocol (STOMP). ActiveMQ , a popular and powerful open source persistence messaging and integration patterns server with scheduler capabilities, acts as a message broker in the framework. STOMP provides an interoperable wire format that allows framework programs to talk and interact between each other and ActiveMQ easily. In order to efficiently use the message broker a unified message and topic naming pattern is utilized to achieve the required operation. Only three Python programs and simple library, used to unify and simplify the implementation of activeMQ and STOMP protocol, are needed to use the framework. A watchdog program is used to monitor, remove, add, start and stop any machine and/or its different tasks when necessary. For every machine a dedicated one and only one zoo keeper program is used to start different functions or tasks, stompShell program, needed for executing the user required workflow. The stompShell instances are used to execute any workflow jobs based on received message. A well-defined, simple and flexible message structure, based on JavaScript Object Notation (JSON), is used to build any complex workflow systems. Also, JSON format is used in configuration, communication between machines and programs. The framework is platform independent. Although, the framework is built using Python the actual workflow programs or jobs can be implemented by any programming language. The generic framework can be used in small national data centres for processing seismological and radionuclide data received from the International Data Centre (IDC) of the Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO). Also, it is possible to extend the use of the framework in monitoring the IDC pipeline. The detailed design, implementation,conclusion and future work of the proposed framework will be presented.

Detection biases yield misleading patterns of species persistence and colonization in fragmented landscapes

USGS Publications Warehouse

Ruiz-Gutierrez, Viviana; Zipkin, Elise F.

2011-01-01

Species occurrence patterns, and related processes of persistence, colonization and turnover, are increasingly being used to infer habitat suitability, predict species distributions, and measure biodiversity potential. The majority of these studies do not account for observational error in their analyses despite growing evidence suggesting that the sampling process can significantly influence species detection and subsequently, estimates of occurrence. We examined the potential biases of species occurrence patterns that can result from differences in detectability across species and habitat types using hierarchical multispecies occupancy models applied to a tropical bird community in an agricultural fragmented landscape. Our results suggest that detection varies widely among species and habitat types. Not incorporating detectability severely biased occupancy dynamics for many species by overestimating turnover rates, producing misleading patterns of persistence and colonization of agricultural habitats, and misclassifying species into ecological categories (i.e., forest specialists and generalists). This is of serious concern, given that most research on the ability of agricultural lands to maintain current levels of biodiversity by and large does not correct for differences in detectability. We strongly urge researchers to apply an inferential framework which explicitly account for differences in detectability to fully characterize species-habitat relationships, correctly guide biodiversity conservation in human-modified landscapes, and generate more accurate predictions of species responses to future changes in environmental conditions.

Motility-Driven Glass and Jamming Transitions in Biological Tissues

NASA Astrophysics Data System (ADS)

Bi, Dapeng; Yang, Xingbo; Marchetti, M. Cristina; Manning, M. Lisa

2016-04-01

Cell motion inside dense tissues governs many biological processes, including embryonic development and cancer metastasis, and recent experiments suggest that these tissues exhibit collective glassy behavior. To make quantitative predictions about glass transitions in tissues, we study a self-propelled Voronoi model that simultaneously captures polarized cell motility and multibody cell-cell interactions in a confluent tissue, where there are no gaps between cells. We demonstrate that the model exhibits a jamming transition from a solidlike state to a fluidlike state that is controlled by three parameters: the single-cell motile speed, the persistence time of single-cell tracks, and a target shape index that characterizes the competition between cell-cell adhesion and cortical tension. In contrast to traditional particulate glasses, we are able to identify an experimentally accessible structural order parameter that specifies the entire jamming surface as a function of model parameters. We demonstrate that a continuum soft glassy rheology model precisely captures this transition in the limit of small persistence times and explain how it fails in the limit of large persistence times. These results provide a framework for understanding the collective solid-to-liquid transitions that have been observed in embryonic development and cancer progression, which may be associated with epithelial-to-mesenchymal transition in these tissues.

Intimate Partner Violence in Young Adulthood: Narratives of Persistence and Desistance*

PubMed Central

Giordano, Peggy C.; Johnson, Wendi L.; Manning, Wendy D.; Longmore, Monica A.; Minter, Mallory D.

2015-01-01

Prior research on patterns of intimate partner violence (IPV) has documented changes over time, but few studies have focused directly on IPV desistance processes. This analysis identifies unique features of IPV, providing a rationale for the focus on this form of behavior cessation. We develop a life-course perspective on social learning as a conceptual framework and draw on qualitative interviews (n = 89) elicited from a sample of young adults who participated in a larger longitudinal study (Toledo Adolescent Relationships Study). The respondents' backgrounds reflected a range of persistence and desistance from IPV perpetration. Our analyses revealed that relationship-based motivations and changes were central features of the narratives of successful desisters, whether articulated as a stand-alone theme or in tandem with other potential “hooks” for change. The analysis provides a counterpoint to individualistic views of desistance processes, highlighting ways in which social experiences foster attitude shifts and associated behavioral changes that respondents tied to this type of behavior change. The analyses of persisters and those for whom change seemed to be a work in progress provide points of contrast and highlight barriers that limit a respondent's desistance potential. We describe implications for theories of desistance as well as for IPV prevention and intervention efforts. PMID:26538680

Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases.

PubMed

Raebel, Marsha A; Schmittdiel, Julie; Karter, Andrew J; Konieczny, Jennifer L; Steiner, John F

2013-08-01

To propose a unifying set of definitions for prescription adherence research utilizing electronic health record prescribing databases, prescription dispensing databases, and pharmacy claims databases and to provide a conceptual framework to operationalize these definitions consistently across studies. We reviewed recent literature to identify definitions in electronic database studies of prescription-filling patterns for chronic oral medications. We then develop a conceptual model and propose standardized terminology and definitions to describe prescription-filling behavior from electronic databases. The conceptual model we propose defines 2 separate constructs: medication adherence and persistence. We define primary and secondary adherence as distinct subtypes of adherence. Metrics for estimating secondary adherence are discussed and critiqued, including a newer metric (New Prescription Medication Gap measure) that enables estimation of both primary and secondary adherence. Terminology currently used in prescription adherence research employing electronic databases lacks consistency. We propose a clear, consistent, broadly applicable conceptual model and terminology for such studies. The model and definitions facilitate research utilizing electronic medication prescribing, dispensing, and/or claims databases and encompasses the entire continuum of prescription-filling behavior. Employing conceptually clear and consistent terminology to define medication adherence and persistence will facilitate future comparative effectiveness research and meta-analytic studies that utilize electronic prescription and dispensing records.

Modeling and replicating statistical topology and evidence for CMB nonhomogeneity

PubMed Central

Agami, Sarit

2017-01-01

Under the banner of “big data,” the detection and classification of structure in extremely large, high-dimensional, data sets are two of the central statistical challenges of our times. Among the most intriguing new approaches to this challenge is “TDA,” or “topological data analysis,” one of the primary aims of which is providing nonmetric, but topologically informative, preanalyses of data which make later, more quantitative, analyses feasible. While TDA rests on strong mathematical foundations from topology, in applications, it has faced challenges due to difficulties in handling issues of statistical reliability and robustness, often leading to an inability to make scientific claims with verifiable levels of statistical confidence. We propose a methodology for the parametric representation, estimation, and replication of persistence diagrams, the main diagnostic tool of TDA. The power of the methodology lies in the fact that even if only one persistence diagram is available for analysis—the typical case for big data applications—the replications permit conventional statistical hypothesis testing. The methodology is conceptually simple and computationally practical, and provides a broadly effective statistical framework for persistence diagram TDA analysis. We demonstrate the basic ideas on a toy example, and the power of the parametric approach to TDA modeling in an analysis of cosmic microwave background (CMB) nonhomogeneity. PMID:29078301

Motivation and engagement in music and sport: testing a multidimensional framework in diverse performance settings.

PubMed

Martin, Andrew J

2008-02-01

The present study assessed the application of a multidimensional model of motivation and engagement (the Motivation and Engagement Wheel) and its accompanying instrumentation (the Motivation and Engagement Scale) to the music and sport domains. Participants were 463 young classical musicians (N=224) and sportspeople (N=239). In both music and sport samples, the data confirmed the good fit of the four hypothesized higher-order dimensions and their 11 first-order dimensions: adaptive cognitions (self-efficacy, valuing, mastery orientation), adaptive behaviors (planning, task management, persistence), impeding/maladaptive cognitions (uncertain control, anxiety, failure avoidance), and maladaptive behaviors (self-handicapping, disengagement). Multigroup tests of factor invariance showed that in terms of underlying motivational constructs and the composition of and relationships among these constructs, key subsamples are not substantially different. Moreover-and of particular relevance to issues around the generalizability of the framework-the factor structure for music and sport samples was predominantly invariant.

Identification and impact of discoverers in online social systems

PubMed Central

Medo, Matúš; Mariani, Manuel S.; Zeng, An; Zhang, Yi-Cheng

2016-01-01

Understanding the behavior of users in online systems is of essential importance for sociology, system design, e-commerce, and beyond. Most existing models assume that individuals in diverse systems, ranging from social networks to e-commerce platforms, tend to what is already popular. We propose a statistical time-aware framework to identify the users who differ from the usual behavior by being repeatedly and persistently among the first to collect the items that later become hugely popular. Since these users effectively discover future hits, we refer them as discoverers. We use the proposed framework to demonstrate that discoverers are present in a wide range of real systems. Once identified, discoverers can be used to predict the future success of new items. We finally introduce a simple network model which reproduces the discovery patterns observed in the real data. Our results open the door to quantitative study of detailed temporal patterns in social systems. PMID:27687588

Toward implementation of a national ground water monitoring network

USGS Publications Warehouse

Schreiber, Robert P.; Cunningham, William L.; Copeland, Rick; Frederick, Kevin D.

2008-01-01

The Federal Advisory Committee on Water Information's (ACWI) Subcommittee on Ground Water (SOGW) has been working steadily to develop and encourage implementation of a nationwide, long-term ground-water quantity and quality monitoring framework. Significant progress includes the planned submission this fall of a draft framework document to the full committee. The document will include recommendations for implementation of the network and continued acknowledgment at the federal and state level of ACWI's potential role in national monitoring toward an improved assessment of the nation's water reserves. The SOGW mission includes addressing several issues regarding network design, as well as developing plans for concept testing, evaluation of costs and benefits, and encouraging the movement from pilot-test results to full-scale implementation within a reasonable time period. With the recent attention to water resource sustainability driven by severe droughts, concerns over global warming effects, and persistent water supply problems, the SOGW mission is now even more critical.

Bullying in the Nursing Workplace: Applying Evidence Using A Conceptual Framework.

PubMed

Lee, Youn Ju; Bernstein, Kunsook; Lee, Mihyoung; Nokes, Kathleen M

2014-01-01

Bullying in the nursing workplace can result in serious health-related outcomes for both nurses and patients who are under their care as well as the health care organizations. Bullying can erode the victim's professional competence and reputation and challenge the victim to maintain and improve professional identity. Although bullying can occur among co-workers, the most common form of bullying involves the abuse of power by superiors against subordinates. Persistent negative behaviors of a perpetrator indicates repeated negative behaviors of at least once or twice weekly by the perpetrator targeting the victim over period of time of at least 6 months and as long as 12 months. Building a conceptual framework of bullying specific to the nursing workplace is warranted to better understand bullying dynamics and its consequences while developing strategies to change the health care environment to a safer workplace for nurses.

Exploring the Factor Structure of the Job Demands-Resources Measure With Patient Violence on Direct Care Workers in the Home Setting.

PubMed

Byon, Ha Do; Harrington, Donna; Storr, Carla L; Lipscomb, Jane

2017-08-01

Workplace violence research in health care settings using the Job Demands-Resources (JD-R) framework is hindered by the lack of comprehensive examination of the factor structure of the JD-R measure when it includes patient violence. Is patient violence a component of job demands or its own factor as an occupational outcome? Exploratory factor analysis and confirmatory factor analysis were conducted using a sample of direct care workers in the home setting (n = 961). The overall 2-construct JD-R structure persisted. Patient violence was not identified as a separate factor from job demands; rather, two demand factors emerged: violence/emotional and workload/physical demands. Although the three-factor model fits the data, the two-factor model with patient violence being a component of job demands is a parsimonious and effective measurement framework.

An Organizational Learning Framework for Patient Safety.

PubMed

Edwards, Marc T

Despite concerted effort to improve quality and safety, high reliability remains a distant goal. Although this likely reflects the challenge of organizational change, persistent controversy over basic issues suggests that weaknesses in conceptual models may contribute. The essence of operational improvement is organizational learning. This article presents a framework for identifying leverage points for improvement based on organizational learning theory and applies it to an analysis of current practice and controversy. Organizations learn from others, from defects, from measurement, and from mindfulness. These learning modes correspond with contemporary themes of collaboration, no blame for human error, accountability for performance, and managing the unexpected. The collaborative model has dominated improvement efforts. Greater attention to the underdeveloped modes of organizational learning may foster more rapid progress in patient safety by increasing organizational capabilities, strengthening a culture of safety, and fixing more of the process problems that contribute to patient harm.

Review of Issues About Classical Change Scores: A Multilevel Modeling Perspective on Some Enduring Beliefs.

PubMed

Gu, Zhengguo; Emons, Wilco H M; Sijtsma, Klaas

2018-04-30

Change scores obtained in pretest-posttest designs are important for evaluating treatment effectiveness and for assessing change of individual test scores in psychological research. However, over the years the use of change scores has raised much controversy. In this article, from a multilevel perspective, we provide a structured treatise on several persistent negative beliefs about change scores and show that these beliefs originated from the confounding of the effects of within-person change on change-score reliability and between-person change differences. We argue that psychometric properties of change scores, such as reliability and measurement precision, should be treated at suitable levels within a multilevel framework. We show that, if examined at the suitable levels with such a framework, the negative beliefs about change scores can be renounced convincingly. Finally, we summarize the conclusions about change scores to dispel the myths and to promote the potential and practical usefulness of change scores.

Modelling household finances: A Bayesian approach to a multivariate two-part model

PubMed Central

Brown, Sarah; Ghosh, Pulak; Su, Li; Taylor, Karl

2016-01-01

We contribute to the empirical literature on household finances by introducing a Bayesian multivariate two-part model, which has been developed to further our understanding of household finances. Our flexible approach allows for the potential interdependence between the holding of assets and liabilities at the household level and also encompasses a two-part process to allow for differences in the influences on asset or liability holding and on the respective amounts held. Furthermore, the framework is dynamic in order to allow for persistence in household finances over time. Our findings endorse the joint modelling approach and provide evidence supporting the importance of dynamics. In addition, we find that certain independent variables exert different influences on the binary and continuous parts of the model thereby highlighting the flexibility of our framework and revealing a detailed picture of the nature of household finances. PMID:27212801

Dynamic Infinite Mixed-Membership Stochastic Blockmodel.

PubMed

Fan, Xuhui; Cao, Longbing; Xu, Richard Yi Da

2015-09-01

Directional and pairwise measurements are often used to model interactions in a social network setting. The mixed-membership stochastic blockmodel (MMSB) was a seminal work in this area, and its ability has been extended. However, models such as MMSB face particular challenges in modeling dynamic networks, for example, with the unknown number of communities. Accordingly, this paper proposes a dynamic infinite mixed-membership stochastic blockmodel, a generalized framework that extends the existing work to potentially infinite communities inside a network in dynamic settings (i.e., networks are observed over time). Additional model parameters are introduced to reflect the degree of persistence among one's memberships at consecutive time stamps. Under this framework, two specific models, namely mixture time variant and mixture time invariant models, are proposed to depict two different time correlation structures. Two effective posterior sampling strategies and their results are presented, respectively, using synthetic and real-world data.

Identification and impact of discoverers in online social systems

NASA Astrophysics Data System (ADS)

Medo, Matúš; Mariani, Manuel S.; Zeng, An; Zhang, Yi-Cheng

2016-09-01

Understanding the behavior of users in online systems is of essential importance for sociology, system design, e-commerce, and beyond. Most existing models assume that individuals in diverse systems, ranging from social networks to e-commerce platforms, tend to what is already popular. We propose a statistical time-aware framework to identify the users who differ from the usual behavior by being repeatedly and persistently among the first to collect the items that later become hugely popular. Since these users effectively discover future hits, we refer them as discoverers. We use the proposed framework to demonstrate that discoverers are present in a wide range of real systems. Once identified, discoverers can be used to predict the future success of new items. We finally introduce a simple network model which reproduces the discovery patterns observed in the real data. Our results open the door to quantitative study of detailed temporal patterns in social systems.

Identification and impact of discoverers in online social systems.

PubMed

Medo, Matúš; Mariani, Manuel S; Zeng, An; Zhang, Yi-Cheng

2016-09-30

Understanding the behavior of users in online systems is of essential importance for sociology, system design, e-commerce, and beyond. Most existing models assume that individuals in diverse systems, ranging from social networks to e-commerce platforms, tend to what is already popular. We propose a statistical time-aware framework to identify the users who differ from the usual behavior by being repeatedly and persistently among the first to collect the items that later become hugely popular. Since these users effectively discover future hits, we refer them as discoverers. We use the proposed framework to demonstrate that discoverers are present in a wide range of real systems. Once identified, discoverers can be used to predict the future success of new items. We finally introduce a simple network model which reproduces the discovery patterns observed in the real data. Our results open the door to quantitative study of detailed temporal patterns in social systems.

Desertification, land use, and the transformation of global drylands

USGS Publications Warehouse

Bestelmeyer, Brandon T.; Okin, Gregory S.; Duniway, Michael C.; Archer, Steven R.; Sayre, Nathan F.; Williamson, Jebediah C.; Herrick, Jeffrey E.

2015-01-01

Desertification is an escalating concern in global drylands, yet assessments to guide management and policy responses are limited by ambiguity concerning the definition of “desertification” and what processes are involved. To improve clarity, we propose that assessments of desertification and land transformation be placed within a state change–land-use change (SC–LUC) framework. This framework considers desertification as state changes occurring within the context of particular land uses (eg rangeland, cropland) that interact with land-use change. State changes that can be readily reversed are distinguished from regime shifts, which are state changes involving persistent alterations to vegetation or soil properties. Pressures driving the transformation of rangelands to other types of land uses may be low, fluctuating, or high, and may influence and be influenced by state change. We discuss how the SC–LUC perspective can guide more effective assessment of desertification and management of drylands.

Modelling plankton ecosystems in the meta-omics era. Are we ready?

PubMed

Stec, Krzysztof Franciszek; Caputi, Luigi; Buttigieg, Pier Luigi; D'Alelio, Domenico; Ibarbalz, Federico Matias; Sullivan, Matthew B; Chaffron, Samuel; Bowler, Chris; Ribera d'Alcalà, Maurizio; Iudicone, Daniele

2017-04-01

Recent progress in applying meta-omics approaches to the study of marine ecosystems potentially allows scientists to study the genetic and functional diversity of plankton at an unprecedented depth and with enhanced precision. However, while a range of persistent technical issues still need to be resolved, a much greater obstacle currently preventing a complete and integrated view of the marine ecosystem is the absence of a clear conceptual framework. Herein, we discuss the knowledge that has thus far been derived from conceptual and statistical modelling of marine plankton ecosystems, and illustrate the potential power of integrated meta-omics approaches in the field. We then propose the use of a semantic framework is necessary to support integrative ecological modelling in the meta-omics era, particularly when having to face the increased interdisciplinarity needed to address global issues related to climate change. Copyright © 2017. Published by Elsevier B.V.

Emerging Fabric of Science: Persistent Identifiers and Knowledge Networks

NASA Astrophysics Data System (ADS)

Hugo, W.

2017-12-01

There is an increasing emphasis on the use of persistent identifiers in the description of scientific activity, whether this is done to cite scholarly publications and research output, reliably identify role players such as funders and researchers, or to provide long-lasting references to controlled vocabulary. The ICSU World Data System has been promoting the establishment of a "Knowledge Network" to describe research activity, realising that parts of the network will be established as a federated `system', based on linkages between registries of persistent identifiers. In addition, there is a growing focus on not only the relationship between these major role players and associated digital objects, but also on the processes of science: provenance, reproducibility, and re-usability being significant topics of discussion. The paper will focus on description of the `Fabric of Science' from the perspectives of both structure and processes, review the state of implementation of real services and infrastructure in support of it. A case is made for inclusion of persistent identifiers into the mainstream activities of scientists and data infrastructure managers, and for the development of services, such as Scholix, to make better use of the relationships between digital objects and major role players. A proposal is made for the adoption of a federated system of services that are based on a hybrid graph-object framework similar to Scholix for recording the activity of scientific research. Finally, links to related ideas are explored: novel ways of representing of knowledge (such as Nanopublications) and the possibility that the publication paradigm currently in use may have to be amended.

What Motivates Biology Instructors to Engage and Persist in Teaching Professional Development?

PubMed

McCourt, Jill S; Andrews, Tessa C; Knight, Jennifer K; Merrill, John E; Nehm, Ross H; Pelletreau, Karen N; Prevost, Luanna B; Smith, Michelle K; Urban-Lurain, Mark; Lemons, Paula P

2017-01-01

We conducted a study of 19 biology instructors participating in small, local groups at six research-intensive universities connected to the Automated Analysis of Constructed Response (AACR) project (www.msu.edu/∼aacr). Our aim was to uncover participants' motivation to persist in a long-term teaching professional development effort, a topic that is understudied in discipline-based educational research. We interviewed each participant twice over a 2-year period and conducted qualitative analyses on the data, using expectancy-value theory as a framework for considering motivation. Our analyses revealed that motivation among instructors was high due to their enjoyment of the AACR groups. The high level of motivation is further explained by the fact that AACR groups facilitated instructor involvement with the larger AACR project. We also found that group dynamics encouraged persistence; instructors thought they might never talk with colleagues about teaching in the absence of AACR groups; and groups were perceived to have a low-enough time requirement to warrant sustained involvement . We conclude that instructors have persisted in AACR groups because the groups provided great value with limited cost. The characterization of instructor experiences described here can contribute to a better understanding of faculty needs in teaching professional development. © 2017 J. S. McCourt et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Clinical practice guideline: tinnitus.

PubMed

Tunkel, David E; Bauer, Carol A; Sun, Gordon H; Rosenfeld, Richard M; Chandrasekhar, Sujana S; Cunningham, Eugene R; Archer, Sanford M; Blakley, Brian W; Carter, John M; Granieri, Evelyn C; Henry, James A; Hollingsworth, Deena; Khan, Fawad A; Mitchell, Scott; Monfared, Ashkan; Newman, Craig W; Omole, Folashade S; Phillips, C Douglas; Robinson, Shannon K; Taw, Malcolm B; Tyler, Richard S; Waguespack, Richard; Whamond, Elizabeth J

2014-10-01

Tinnitus is the perception of sound without an external source. More than 50 million people in the United States have reported experiencing tinnitus, resulting in an estimated prevalence of 10% to 15% in adults. Despite the high prevalence of tinnitus and its potential significant effect on quality of life, there are no evidence-based, multidisciplinary clinical practice guidelines to assist clinicians with management. The focus of this guideline is on tinnitus that is both bothersome and persistent (lasting 6 months or longer), which often negatively affects the patient's quality of life. The target audience for the guideline is any clinician, including nonphysicians, involved in managing patients with tinnitus. The target patient population is limited to adults (18 years and older) with primary tinnitus that is persistent and bothersome. The purpose of this guideline is to provide evidence-based recommendations for clinicians managing patients with tinnitus. This guideline provides clinicians with a logical framework to improve patient care and mitigate the personal and social effects of persistent, bothersome tinnitus. It will discuss the evaluation of patients with tinnitus, including selection and timing of diagnostic testing and specialty referral to identify potential underlying treatable pathology. It will then focus on the evaluation and treatment of patients with persistent primary tinnitus, with recommendations to guide the evaluation and measurement of the effect of tinnitus and to determine the most appropriate interventions to improve symptoms and quality of life for tinnitus sufferers. The development group made a strong recommendation that clinicians distinguish patients with bothersome tinnitus from patients with nonbothersome tinnitus. The development group made a strong recommendation against obtaining imaging studies of the head and neck in patients with tinnitus, specifically to evaluate tinnitus that does not localize to 1 ear, is nonpulsatile, and is not associated with focal neurologic abnormalities or an asymmetric hearing loss. The panel made the following recommendations: Clinicians should (a) perform a targeted history and physical examination at the initial evaluation of a patient with presumed primary tinnitus to identify conditions that if promptly identified and managed may relieve tinnitus; (b) obtain a prompt, comprehensive audiologic examination in patients with tinnitus that is unilateral, persistent (≥ 6 months), or associated with hearing difficulties; (c) distinguish patients with bothersome tinnitus of recent onset from those with persistent symptoms (≥ 6 months) to prioritize intervention and facilitate discussions about natural history and follow-up care; (d) educate patients with persistent, bothersome tinnitus about management strategies; (e) recommend a hearing aid evaluation for patients who have persistent, bothersome tinnitus associated with documented hearing loss; and (f) recommend cognitive behavioral therapy to patients with persistent, bothersome tinnitus. The panel recommended against (a) antidepressants, anticonvulsants, anxiolytics, or intratympanic medications for the routine treatment of patients with persistent, bothersome tinnitus; (b) Ginkgo biloba, melatonin, zinc, or other dietary supplements for treating patients with persistent, bothersome tinnitus; and (c) transcranial magnetic stimulation for the routine treatment of patients with persistent, bothersome tinnitus. The development group provided the following options: Clinicians may (a) obtain an initial comprehensive audiologic examination in patients who present with tinnitus (regardless of laterality, duration, or perceived hearing status); and (b) recommend sound therapy to patients with persistent, bothersome tinnitus. The development group provided no recommendation regarding the effect of acupuncture in patients with persistent, bothersome tinnitus. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

[Living donors for kidney transplantation: ethical and legal challenges].

PubMed

Mamzer-Bruneel, Marie-France; Fournier, Catherine; Legendre, Christophe

2010-05-01

Living donor kidney transplantation has developed very heterogeneously worldwide despite excellent results and without taking into account the context of global organ shortage. Such a heterogeneity highlights persistent ethical issues, whereas organ trafficking is emerging as an organized transplant tourism reinforcing the need for strong national legal frameworks. Despite its powerful regulation system, which ensures standardization, transparency and accountability of support for donation, France remains reluctant to enlarge the circle of legal donors, whereas it would be the first step to give a greater role to living organ donation.

A model for architectural comparison

NASA Astrophysics Data System (ADS)

Ho, Sam; Snyder, Larry

1988-04-01

Recently, architectures for sequential computers became a topic of much discussion and controversy. At the center of this storm is the Reduced Instruction Set Computer, or RISC, first described at Berkeley in 1980. While the merits of the RISC architecture cannot be ignored, its opponents have tried to do just that, while its proponents have expanded and frequently exaggerated them. This state of affairs has persisted to this day. No attempt is made to settle this controversy, since indeed there is likely no one answer. A qualitative framework is provided for a rational discussion of the issues.

Progress and pitfalls in Shigella vaccine research

PubMed Central

Barry, Eileen M.; Pasetti, Marcela F.; Sztein, Marcelo B.; Fasano, Alessio; Kotloff, Karen L.; Levine, Myron M.

2013-01-01

Renewed awareness of the significant morbidity and mortality that Shigella causes among young children in developing countries combined with technological innovations in vaccinology has led to the development of novel vaccine strategies in the past five years. Along with advancement of classical vaccines in clinical trials and new sophisticated measurements of immunological responses, much new data has been produced lending promise to the potential for production of safe and effective Shigella vaccines. Herein we review the recent progress in Shigella vaccine development within the framework of persistent obstacles. PMID:23419287

Computable visually observed phenotype ontological framework for plants

PubMed Central

2011-01-01

Background The ability to search for and precisely compare similar phenotypic appearances within and across species has vast potential in plant science and genetic research. The difficulty in doing so lies in the fact that many visual phenotypic data, especially visually observed phenotypes that often times cannot be directly measured quantitatively, are in the form of text annotations, and these descriptions are plagued by semantic ambiguity, heterogeneity, and low granularity. Though several bio-ontologies have been developed to standardize phenotypic (and genotypic) information and permit comparisons across species, these semantic issues persist and prevent precise analysis and retrieval of information. A framework suitable for the modeling and analysis of precise computable representations of such phenotypic appearances is needed. Results We have developed a new framework called the Computable Visually Observed Phenotype Ontological Framework for plants. This work provides a novel quantitative view of descriptions of plant phenotypes that leverages existing bio-ontologies and utilizes a computational approach to capture and represent domain knowledge in a machine-interpretable form. This is accomplished by means of a robust and accurate semantic mapping module that automatically maps high-level semantics to low-level measurements computed from phenotype imagery. The framework was applied to two different plant species with semantic rules mined and an ontology constructed. Rule quality was evaluated and showed high quality rules for most semantics. This framework also facilitates automatic annotation of phenotype images and can be adopted by different plant communities to aid in their research. Conclusions The Computable Visually Observed Phenotype Ontological Framework for plants has been developed for more efficient and accurate management of visually observed phenotypes, which play a significant role in plant genomics research. The uniqueness of this framework is its ability to bridge the knowledge of informaticians and plant science researchers by translating descriptions of visually observed phenotypes into standardized, machine-understandable representations, thus enabling the development of advanced information retrieval and phenotype annotation analysis tools for the plant science community. PMID:21702966

Mineral-associated organic matter: are we now on the right path to accurately measuring and modelling it?

NASA Astrophysics Data System (ADS)

Cotrufo, M. F.

2017-12-01

Mineral-associated organic matter (MAOM) is the largest and most persistent pool of carbon in soil. Understanding and correctly modeling its dynamic is key to suggest management practices that can augment soil carbon storage for climate change mitigation, as well as increase soil organic matter (SOM) stocks to support soil health on the long-term. In the Microbial Efficiency Mineral Stabilization (MEMS) framework we proposed that, contrary to what originally thought, this form of persistent SOM is derived from the labile components of plant inputs, through their efficient microbial processing. I will present results from several experiments using dual isotope labeling of plant inputs that largely confirm this opinion, and point to the key role of dissolved organic matter in MAOM formation, and to the dynamic nature of the outer layer of MAOM. I will also show how we are incorporating this understanding in a new SOM model, which uses physically defined measurable pools rather than turnover-defined pools to forecast C cycling in soil.

Endemic cattle diseases: comparative epidemiology and governance

PubMed Central

Carslake, David; Grant, Wyn; Green, Laura E.; Cave, Jonathan; Greaves, Justin; Keeling, Matt; McEldowney, John; Weldegebriel, Habtu; Medley, Graham F.

2011-01-01

Cattle are infected by a community of endemic pathogens with different epidemiological properties that invoke different managerial and governmental responses. We present characteristics of pathogens that influence their ability to persist in the UK, and describe a qualitative framework of factors that influence the political response to a livestock disease. We develop simple transmission models for three pathogens (bovine viral diarrhoea virus, bovine herpesvirus and Mycobacterium avium spp. paratuberculosis) using observed cattle movements, and compare the outcomes to an extensive dataset. The results demonstrate that the epidemiology of the three pathogens is determined by different aspects of within- and between-farm processes, which has economic, legal and political implications for control. We consider how these pathogens, and Mycobacterium bovis (the agent of bovine tuberculosis), may be classified by the process by which they persist and by their political profile. We further consider the dynamic interaction of these classifications with pathogen prevalence and with the action taken by the government. PMID:21624918

Global Health Governance at a Crossroads.

PubMed

Ng, Nora Y; Ruger, Jennifer Prah

2011-06-21

This review takes stock of the global health governance (GHG) literature. We address the transition from international health governance (IHG) to global health governance, identify major actors, and explain some challenges and successes in GHG. We analyze the framing of health as national security, human security, human rights, and global public good, and the implications of these various frames. We also establish and examine from the literature GHG's major themes and issues, which include: 1) persistent GHG problems; 2) different approaches to tackling health challenges (vertical, horizontal, and diagonal); 3) health's multisectoral connections; 4) neoliberalism and the global economy; 5) the framing of health (e.g. as a security issue, as a foreign policy issue, as a human rights issue, and as a global public good); 6) global health inequalities; 7) local and country ownership and capacity; 8) international law in GHG; and 9) research gaps in GHG. We find that decades-old challenges in GHG persist and GHG needs a new way forward. A framework called shared health governance offers promise.

Selective mutism: a review of etiology, comorbidities, and treatment.

PubMed

Wong, Priscilla

2010-03-01

Selective mutism is a rare and multidimensional childhood disorder that typically affects children entering school age. It is characterized by the persistent failure to speak in select social settings despite possessing the ability to speak and speak comfortably in more familiar settings. Many theories attempt to explain the etiology of selective mutism.Comorbidities and treatment. Selective mutism can present a variety of comorbidities including enuresis, encopresis, obsessive-compulsive disorder, depression, premorbid speech and language abnormalities, developmental delay, and Asperger's disorders. The specific manifestations and severity of these comorbidities vary based on the individual. Given the multidimensional manifestations of selective mutism, treatment options are similarly diverse. They include individual behavioral therapy, family therapy, and psychotherapy with antidepressants and anti-anxiety medications.Future directions. While studies have helped to elucidate the phenomenology of selective mutism, limitations and gaps in knowledge still persist. In particular, the literature on selective mutism consists primarily of small sample populations and case reports. Future research aims to develop an increasingly integrated, multidimensional framework for evaluating and treating children with selective mutism.

Selective Mutism

PubMed Central

2010-01-01

Selective mutism is a rare and multidimensional childhood disorder that typically affects children entering school age. It is characterized by the persistent failure to speak in select social settings despite possessing the ability to speak and speak comfortably in more familiar settings. Many theories attempt to explain the etiology of selective mutism. Comorbidities and treatment. Selective mutism can present a variety of comorbidities including enuresis, encopresis, obsessive-compulsive disorder, depression, premorbid speech and language abnormalities, developmental delay, and Asperger's disorders. The specific manifestations and severity of these comorbidities vary based on the individual. Given the multidimensional manifestations of selective mutism, treatment options are similarly diverse. They include individual behavioral therapy, family therapy, and psychotherapy with antidepressants and anti-anxiety medications. Future directions. While studies have helped to elucidate the phenomenology of selective mutism, limitations and gaps in knowledge still persist. In particular, the literature on selective mutism consists primarily of small sample populations and case reports. Future research aims to develop an increasingly integrated, multidimensional framework for evaluating and treating children with selective mutism. PMID:20436772

Ecosystem functioning is enveloped by hydrometeorological variability.

PubMed

Pappas, Christoforos; Mahecha, Miguel D; Frank, David C; Babst, Flurin; Koutsoyiannis, Demetris

2017-09-01

Terrestrial ecosystem processes, and the associated vegetation carbon dynamics, respond differently to hydrometeorological variability across timescales, and so does our scientific understanding of the underlying mechanisms. Long-term variability of the terrestrial carbon cycle is not yet well constrained and the resulting climate-biosphere feedbacks are highly uncertain. Here we present a comprehensive overview of hydrometeorological and ecosystem variability from hourly to decadal timescales integrating multiple in situ and remote-sensing datasets characterizing extra-tropical forest sites. We find that ecosystem variability at all sites is confined within a hydrometeorological envelope across sites and timescales. Furthermore, ecosystem variability demonstrates long-term persistence, highlighting ecological memory and slow ecosystem recovery rates after disturbances. However, simulation results with state-of-the-art process-based models do not reflect this long-term persistent behaviour in ecosystem functioning. Accordingly, we develop a cross-time-scale stochastic framework that captures hydrometeorological and ecosystem variability. Our analysis offers a perspective for terrestrial ecosystem modelling and paves the way for new model-data integration opportunities in Earth system sciences.

The Impact of Low-Level Cloud Feedback on Persistent Changes in Atmospheric Circulation in the Pacific

NASA Astrophysics Data System (ADS)

Burgman, R.; Kirtman, B. P.; Clement, A. C.; Vazquez, H.

2017-12-01

Recent studies suggest that low clouds in the Pacific play an important role in the observed decadal climate variability and future climate change. In this study, we implement a novel modeling experiment designed to isolate how interactions between local and remote feedbacks associated with low cloud, SSTs, and the largescale circulation play a significant role in the observed persistence of tropical Pacific SST and associated North American drought. The modeling approach involves the incorporation of observed patterns of satellite-derived shortwave cloud radiative effect (SWCRE) into the coupled model framework and is ideally suited for examining the role of local and large-scale coupled feedbacks and ocean heat transport in Pacific decadal variability. We show that changes in SWCRE forcing in eastern subtropical Pacific alone reproduces much of the observed changes in SST and atmospheric circulation over the past 16 years, including the observed changes in precipitation over much of the Western Hemisphere.

Multipulse interaction quenched ultracold few-bosonic ensembles in finite optical lattices

NASA Astrophysics Data System (ADS)

Mistakidis, Simeon; Neuhaus-Steinmetz, Jannis; Schmelcher, Peter; Theory Group of Fundamental Processes in Quantum Physics Team

2017-04-01

The correlated non-equilibrium dynamics following a multipulse interaction quench protocol in few-bosonic ensembles confined in finite optical lattices is investigated. The multipulse interaction quench gives rise to the cradle and a global breathing mode. These modes are generated during the interaction pulse and persist also after the pulse. The corresponding tunneling dynamics consists of several energy channels accompanying the dynamics. The majority of the tunneling channels persist after the pulse, while only a few occur during the pulse. The induced excitation dynamics is also explored and a strong non-linear dependence on the delayed time of the multipulse protocol is observed. Moreover, the character of the excitation dynamics is also manifested by the periodic population of higher-lying lattice momenta. The above mentioned findings pave the way for future investigations on the direct control of the excitation dynamics. Deutsche Forschungsgemeinschaft (DFG) in the framework of the SFB 925 ``Light induced dynamics and control of correlated quantum systems''.

Impact of prolonged storm activity on the Ecological Status of intertidal benthic habitats within oyster (Crassostrea gigas) trestle cultivation sites.

PubMed

O'Carroll, Jack P J; Quinn, Christina; Forde, James; Patterson, Adrian; O'Beirn, Francis X; Kennedy, Robert

2016-09-15

The Ecological Status (ES; sensu the Water Framework Directive) of intertidal benthic communities within six oyster trestle cultivation sites was found to be negatively impacted along the access routes to trestles in a 2013 study. All cultivation sites occur within Natura 2000 sites. The current study revisited four of the 2013 cultivation sites in February 2014 one month after the storm activity of winter 2013/14 to test if the compaction effect along access routes persisted after the storms. Three levels of the fixed factor treatment were sampled; immediately below the trestles, along the access route and 300m away from any anthropogenic activity. The compaction effect at the Access treatment persisted in spite of the major storm activity. The current study showed the IQI to be effective for assessing the impacts of aquaculture and highlights the IQI as a tool for monitoring Conservation Status of intertidal communities under the Habitats Directive. Copyright © 2016 Elsevier Ltd. All rights reserved.

Global Health Governance at a Crossroads

PubMed Central

Ng, Nora Y.; Ruger, Jennifer Prah

2014-01-01

This review takes stock of the global health governance (GHG) literature. We address the transition from international health governance (IHG) to global health governance, identify major actors, and explain some challenges and successes in GHG. We analyze the framing of health as national security, human security, human rights, and global public good, and the implications of these various frames. We also establish and examine from the literature GHG’s major themes and issues, which include: 1) persistent GHG problems; 2) different approaches to tackling health challenges (vertical, horizontal, and diagonal); 3) health’s multisectoral connections; 4) neoliberalism and the global economy; 5) the framing of health (e.g. as a security issue, as a foreign policy issue, as a human rights issue, and as a global public good); 6) global health inequalities; 7) local and country ownership and capacity; 8) international law in GHG; and 9) research gaps in GHG. We find that decades-old challenges in GHG persist and GHG needs a new way forward. A framework called shared health governance offers promise. PMID:24729828

Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs

NASA Astrophysics Data System (ADS)

Komarova, Natalia L.; Levy, David N.; Wodarz, Dominik

2013-07-01

Cell-to-cell viral transmission via virological synapses has been argued to reduce susceptibility of the virus population to anti-viral drugs through multiple infection of cells, contributing to low-level viral persistence during therapy. Using a mathematical framework, we examine the role of synaptic transmission in treatment susceptibility. A key factor is the relative probability of individual virions to infect a cell during free-virus and synaptic transmission, a currently unknown quantity. If this infection probability is higher for free-virus transmission, then treatment susceptibility is lowest if one virus is transferred per synapse, and multiple infection of cells increases susceptibility. In the opposite case, treatment susceptibility is minimized for an intermediate number of virions transferred per synapse. Hence, multiple infection via synapses does not simply lower treatment susceptibility. Without further experimental investigations, one cannot conclude that synaptic transmission provides an additional mechanism for the virus to persist at low levels during anti-viral therapy.

Discovering Coherent Structures Using Local Causal States

NASA Astrophysics Data System (ADS)

Rupe, Adam; Crutchfield, James P.; Kashinath, Karthik; Prabhat, Mr.

2017-11-01

Coherent structures were introduced in the study of fluid dynamics and were initially defined as regions characterized by high levels of coherent vorticity, i.e. regions where instantaneously space and phase correlated vorticity are high. In a more general spatiotemporal setting, coherent structures can be seen as localized broken symmetries which persist in time. Building off the computational mechanics framework, which integrates tools from computation and information theory to capture pattern and structure in nonlinear dynamical systems, we introduce a theory of coherent structures, in the more general sense. Central to computational mechanics is the causal equivalence relation, and a local spatiotemporal generalization of it is used to construct the local causal states, which are utilized to uncover a system's spatiotemporal symmetries. Coherent structures are then identified as persistent, localized deviations from these symmetries. We illustrate how novel patterns and structures can be discovered in cellular automata and outline the path from them to laminar, transitional and turbulent flows. Funded by Intel through the Big Data Center at LBNL and the IPCC at UC Davis.

A spatially integrated framework for assessing socioecological drivers of carnivore decline.

PubMed

Gálvez, Nicolás; Guillera-Arroita, Gurutzeta; St John, Freya A V; Schüttler, Elke; Macdonald, David W; Davies, Zoe G

2018-05-01

Habitat loss, fragmentation and degradation are key threats to the long-term persistence of carnivores, which are also susceptible to direct persecution by people. Integrating natural and social science methods to examine how habitat configuration/quality and human-predator relations may interact in space and time to effect carnivore populations within human-dominated landscapes will help prioritise conservation investment and action effectively.We propose a socioecological modelling framework to evaluate drivers of carnivore decline in landscapes where predators and people coexist. By collecting social and ecological data at the same spatial scale, candidate models can be used to quantify and tease apart the relative importance of different threats.We apply our methodological framework to an empirical case study, the threatened güiña ( Leopardus guigna ) in the temperate forest ecoregion of southern Chile, to illustrate its use. Existing literature suggests that the species is declining due to habitat loss, fragmentation and persecution in response to livestock predation. Data used in modelling were derived from four seasons of camera-trap surveys, remote-sensed images and household questionnaires.Occupancy dynamics were explained by habitat configuration/quality covariates rather than by human-predator relations. Güiñas can tolerate a high degree of habitat loss (>80% within a home range). They are primarily impacted by fragmentation and land subdivision (larger farms being divided into smaller ones). Ten per cent of surveyed farmers ( N  = 233) reported illegally killing the species over the past decade. Synthesis and applications . By integrating ecological and social data, collected at the same spatial scale, within a single modelling framework, our study demonstrates the value of an interdisciplinary approach to assessing the potential threats to a carnivore. It has allowed us to tease apart effectively the relative importance of different potential extinction pressures for the güiña ( Leopardus guigna ), make informed conservation recommendations and prioritise where future interventions should be targeted. We have identified that human-dominated landscapes with large intensive farms can be of conservation value, as long as an appropriate network of habitat patches is maintained within the matrix. Conservation efforts to secure the long-term persistence of the species should focus on reducing habitat fragmentation rather than human persecution.

Phenotypic switching in bacteria

NASA Astrophysics Data System (ADS)

Merrin, Jack

Living matter is a non-equilibrium system in which many components work in parallel to perpetuate themselves through a fluctuating environment. Physiological states or functionalities revealed by a particular environment are called phenotypes. Transitions between phenotypes may occur either spontaneously or via interaction with the environment. Even in the same environment, genetically identical bacteria can exhibit different phenotypes of a continuous or discrete nature. In this thesis, we pursued three lines of investigation into discrete phenotypic heterogeneity in bacterial populations: the quantitative characterization of the so-called bacterial persistence, a theoretical model of phenotypic switching based on those measurements, and the design of artificial genetic networks which implement this model. Persistence is the phenotype of a subpopulation of bacteria with a reduced sensitivity to antibiotics. We developed a microfluidic apparatus, which allowed us to monitor the growth rates of individual cells while applying repeated cycles of antibiotic treatments. We were able to identify distinct phenotypes (normal and persistent) and characterize the stochastic transitions between them. We also found that phenotypic heterogeneity was present prior to any environmental cue such as antibiotic exposure. Motivated by the experiments with persisters, we formulated a theoretical model describing the dynamic behavior of several discrete phenotypes in a periodically varying environment. This theoretical framework allowed us to quantitatively predict the fitness of dynamic populations and to compare survival strategies according to environmental time-symmetries. These calculations suggested that persistence is a strategy used by bacterial populations to adapt to fluctuating environments. Knowledge of the phenotypic transition rates for persistence may provide statistical information about the typical environments of bacteria. We also describe a design of artificial genetic networks that would implement a more general theoretical model of phenotypic switching. We will use a new cloning strategy in order to systematically assemble a large number of genetic features, such as site-specific recombination components from the R64 plasmid, which invert several coexisting DNA segments. The inversion of these segments would lead to discrete phenotypic transitions inside a living cell. These artificial phenotypic switches can be controlled precisely in experiments and may serve as a benchmark for their natural counterparts.

An Integrated Modeling Framework Forecasting Ecosystem Exposure-- A Systems Approach to the Cumulative Impacts of Multiple Stressors

NASA Astrophysics Data System (ADS)

Johnston, J. M.

2013-12-01

Freshwater habitats provide fishable, swimmable and drinkable resources and are a nexus of geophysical and biological processes. These processes in turn influence the persistence and sustainability of populations, communities and ecosystems. Climate change and landuse change encompass numerous stressors of potential exposure, including the introduction of toxic contaminants, invasive species, and disease in addition to physical drivers such as temperature and hydrologic regime. A systems approach that includes the scientific and technologic basis of assessing the health of ecosystems is needed to effectively protect human health and the environment. The Integrated Environmental Modeling Framework 'iemWatersheds' has been developed as a consistent and coherent means of forecasting the cumulative impact of co-occurring stressors. The Framework consists of three facilitating technologies: Data for Environmental Modeling (D4EM) that automates the collection and standardization of input data; the Framework for Risk Assessment of Multimedia Environmental Systems (FRAMES) that manages the flow of information between linked models; and the Supercomputer for Model Uncertainty and Sensitivity Evaluation (SuperMUSE) that provides post-processing and analysis of model outputs, including uncertainty and sensitivity analysis. Five models are linked within the Framework to provide multimedia simulation capabilities for hydrology and water quality processes: the Soil Water Assessment Tool (SWAT) predicts surface water and sediment runoff and associated contaminants; the Watershed Mercury Model (WMM) predicts mercury runoff and loading to streams; the Water quality Analysis and Simulation Program (WASP) predicts water quality within the stream channel; the Habitat Suitability Index (HSI) model scores physicochemical habitat quality for individual fish species; and the Bioaccumulation and Aquatic System Simulator (BASS) predicts fish growth, population dynamics and bioaccumulation of toxic substances. The capability of the Framework to address cumulative impacts will be demonstrated for freshwater ecosystem services and mountaintop mining.

Coalescent: an open-source and scalable framework for exact calculations in coalescent theory

PubMed Central

2012-01-01

Background Currently, there is no open-source, cross-platform and scalable framework for coalescent analysis in population genetics. There is no scalable GUI based user application either. Such a framework and application would not only drive the creation of more complex and realistic models but also make them truly accessible. Results As a first attempt, we built a framework and user application for the domain of exact calculations in coalescent analysis. The framework provides an API with the concepts of model, data, statistic, phylogeny, gene tree and recursion. Infinite-alleles and infinite-sites models are considered. It defines pluggable computations such as counting and listing all the ancestral configurations and genealogies and computing the exact probability of data. It can visualize a gene tree, trace and visualize the internals of the recursion algorithm for further improvement and attach dynamically a number of output processors. The user application defines jobs in a plug-in like manner so that they can be activated, deactivated, installed or uninstalled on demand. Multiple jobs can be run and their inputs edited. Job inputs are persisted across restarts and running jobs can be cancelled where applicable. Conclusions Coalescent theory plays an increasingly important role in analysing molecular population genetic data. Models involved are mathematically difficult and computationally challenging. An open-source, scalable framework that lets users immediately take advantage of the progress made by others will enable exploration of yet more difficult and realistic models. As models become more complex and mathematically less tractable, the need for an integrated computational approach is obvious. Object oriented designs, though has upfront costs, are practical now and can provide such an integrated approach. PMID:23033878

Framework for e-learning assessment in dental education: a global model for the future.

PubMed

Arevalo, Carolina R; Bayne, Stephen C; Beeley, Josie A; Brayshaw, Christine J; Cox, Margaret J; Donaldson, Nora H; Elson, Bruce S; Grayden, Sharon K; Hatzipanagos, Stylianos; Johnson, Lynn A; Reynolds, Patricia A; Schönwetter, Dieter J

2013-05-01

The framework presented in this article demonstrates strategies for a global approach to e-curricula in dental education by considering a collection of outcome assessment tools. By combining the outcomes for overall assessment, a global model for a pilot project that applies e-assessment tools to virtual learning environments (VLE), including haptics, is presented. Assessment strategies from two projects, HapTEL (Haptics in Technology Enhanced Learning) and UDENTE (Universal Dental E-learning), act as case-user studies that have helped develop the proposed global framework. They incorporate additional assessment tools and include evaluations from questionnaires and stakeholders' focus groups. These measure each of the factors affecting the classical teaching/learning theory framework as defined by Entwistle in a standardized manner. A mathematical combinatorial approach is proposed to join these results together as a global assessment. With the use of haptic-based simulation learning, exercises for tooth preparation assessing enamel and dentine were compared to plastic teeth in manikins. Equivalence for student performance for haptic versus traditional preparation methods was established, thus establishing the validity of the haptic solution for performing these exercises. Further data collected from HapTEL are still being analyzed, and pilots are being conducted to validate the proposed test measures. Initial results have been encouraging, but clearly the need persists to develop additional e-assessment methods for new learning domains.

Design, implementation and validation of a novel open framework for agile development of mobile health applications

PubMed Central

2015-01-01

The delivery of healthcare services has experienced tremendous changes during the last years. Mobile health or mHealth is a key engine of advance in the forefront of this revolution. Although there exists a growing development of mobile health applications, there is a lack of tools specifically devised for their implementation. This work presents mHealthDroid, an open source Android implementation of a mHealth Framework designed to facilitate the rapid and easy development of mHealth and biomedical apps. The framework is particularly planned to leverage the potential of mobile devices such as smartphones or tablets, wearable sensors and portable biomedical systems. These devices are increasingly used for the monitoring and delivery of personal health care and wellbeing. The framework implements several functionalities to support resource and communication abstraction, biomedical data acquisition, health knowledge extraction, persistent data storage, adaptive visualization, system management and value-added services such as intelligent alerts, recommendations and guidelines. An exemplary application is also presented along this work to demonstrate the potential of mHealthDroid. This app is used to investigate on the analysis of human behavior, which is considered to be one of the most prominent areas in mHealth. An accurate activity recognition model is developed and successfully validated in both offline and online conditions. PMID:26329639

A framework for activity detection in wide-area motion imagery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porter, Reid B; Ruggiero, Christy E; Morrison, Jack D

2009-01-01

Wide-area persistent imaging systems are becoming increasingly cost effective and now large areas of the earth can be imaged at relatively high frame rates (1-2 fps). The efficient exploitation of the large geo-spatial-temporal datasets produced by these systems poses significant technical challenges for image and video analysis and data mining. In recent years there has been significant progress made on stabilization, moving object detection and tracking and automated systems now generate hundreds to thousands of vehicle tracks from raw data, with little human intervention. However, the tracking performance at this scale, is unreliable and average track length is much smallermore » than the average vehicle route. This is a limiting factor for applications which depend heavily on track identity, i.e. tracking vehicles from their points of origin to their final destination. In this paper we propose and investigate a framework for wide-area motion imagery (W AMI) exploitation that minimizes the dependence on track identity. In its current form this framework takes noisy, incomplete moving object detection tracks as input, and produces a small set of activities (e.g. multi-vehicle meetings) as output. The framework can be used to focus and direct human users and additional computation, and suggests a path towards high-level content extraction by learning from the human-in-the-loop.« less

Towards the intrahour forecasting of direct normal irradiance using sky-imaging data.

PubMed

Nou, Julien; Chauvin, Rémi; Eynard, Julien; Thil, Stéphane; Grieu, Stéphane

2018-04-01

Increasing power plant efficiency through improved operation is key in the development of Concentrating Solar Power (CSP) technologies. To this end, one of the most challenging topics remains accurately forecasting the solar resource at a short-term horizon. Indeed, in CSP plants, production is directly impacted by both the availability and variability of the solar resource and, more specifically, by Direct Normal Irradiance (DNI). The present paper deals with a new approach to the intrahour forecasting (the forecast horizon [Formula: see text] is up to [Formula: see text] ahead) of DNI, taking advantage of the fact that this quantity can be split into two terms, i.e. clear-sky DNI and the clear sky index. Clear-sky DNI is forecasted from DNI measurements, using an empirical model (Ineichen and Perez, 2002) combined with a persistence of atmospheric turbidity. Moreover, in the framework of the CSPIMP (Concentrating Solar Power plant efficiency IMProvement) research project, PROMES-CNRS has developed a sky imager able to provide High Dynamic Range (HDR) images. So, regarding the clear-sky index, it is forecasted from sky-imaging data, using an Adaptive Network-based Fuzzy Inference System (ANFIS). A hybrid algorithm that takes inspiration from the classification algorithm proposed by Ghonima et al. (2012) when clear-sky anisotropy is known and from the hybrid thresholding algorithm proposed by Li et al. (2011) in the opposite case has been developed to the detection of clouds. Performance is evaluated via a comparative study in which persistence models - either a persistence of DNI or a persistence of the clear-sky index - are included. Preliminary results highlight that the proposed approach has the potential to outperform these models (both persistence models achieve similar performance) in terms of forecasting accuracy: over the test data used, RMSE (the Root Mean Square Error) is reduced of about [Formula: see text], with [Formula: see text], and [Formula: see text], with [Formula: see text].

Invited review: effect, persistence, and virulence of coagulase-negative Staphylococcus species associated with ruminant udder health.

PubMed

Vanderhaeghen, W; Piepers, S; Leroy, F; Van Coillie, E; Haesebrouck, F; De Vliegher, S

2014-09-01

The aim of this review is to assess the effect of coagulase-negative staphylococci (CNS) species on udder health and milk yield in ruminants, and to evaluate the capacity of CNS to cause persistent intramammary infections (IMI). Furthermore, the literature on factors suspected of playing a role in the pathogenicity of IMI-associated CNS, such as biofilm formation and the presence of various putative virulence genes, is discussed. The focus is on the 5 CNS species that have been most frequently identified as causing bovine IMI using reliable molecular identification methods (Staphylococcus chromogenes, Staphylococcus simulans, Staphylococcus haemolyticus, Staphylococcus xylosus, and Staphylococcus epidermidis). Although the effect on somatic cell count and milk production is accepted to be generally limited or nonexistent for CNS as a group, indications are that the typical effects differ between CNS species and perhaps even strains. It has also become clear that many CNS species can cause persistent IMI, contrary to what has long been believed. However, this trait appears to be quite complicated, being partly strain dependent and partly dependent on the host's immunity. Consistent definitions of persistence and more uniform methods for testing this phenomenon will benefit future research. The factors explaining the anticipated differences in pathogenic behavior appear to be more difficult to evaluate. Biofilm formation and the presence of various staphylococcal virulence factors do not seem to (directly) influence the effect of CNS on IMI but the available information is indirect or insufficient to draw consistent conclusions. Future studies on the effect, persistence, and virulence of the different CNS species associated with IMI would benefit from using larger and perhaps even shared strain collections and from adjusting study designs to a common framework, as the large variation currently existing therein is a major problem. Also within-species variation should be investigated. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

A quantitative analysis on the effects of critical factors limiting the effectiveness of species conservation in future time.

PubMed

Alagador, Diogo; Cerdeira, Jorge Orestes

2018-03-01

The effectiveness of conservation plans depends on environmental, ecological, and socioeconomic factors. Global change makes conservation decisions even more challenging. Among others, the components of most concern in modern-day conservation assessments are as follows: the magnitude of climate and land-use changes; species dispersal abilities; competition with harmful socioeconomic activities for land use; the number of threatened species to consider; and, relatedly, the available budget to act. Here, we provide a unified framework that quantifies the relative effects of those factors on conservation. We conducted an area-scheduling work plan in order to identify sets of areas along time in which the persistence expectancies of species are optimized. The approach was illustrated using data of potential distribution of ten nonvolant mammal species in Iberia Peninsula from current time up to 2080. Analyses were conducted considering possible setups among the factors that are likely to critically impact conservation success: three climate/land-use scenarios; four species' dispersal kernel curves; six land-use layer types; and two planning designs, in which assessments were made independently for each species, or joining all species in a single plan. We identified areas for an array of investments levels capable to circumvent the spatial conflicts with socioeconomic activities. The effect of each factor on the estimated species persistence scores was assessed using linear mixed models. Our results evidence that conservation success is highly reliant on the resources available to abate land-use conflicts. Nonetheless, under the same investment levels, planning design and climate change were the factors that most shaped species persistence scores. The persistence of five species was especially affected by the sole effect of planning design and consequently, larger conservation investments may retard climatic debts. For three species, the negative effects of a changing climate and of multiple-species planning designs added up, making these species especially at risk. Integrated assessments of the factors most likely to limit species persistence are pivotal to achieve effectiveness.

Explaining evolution via constrained persistent perfect phylogeny

PubMed Central

2014-01-01

Background The perfect phylogeny is an often used model in phylogenetics since it provides an efficient basic procedure for representing the evolution of genomic binary characters in several frameworks, such as for example in haplotype inference. The model, which is conceptually the simplest, is based on the infinite sites assumption, that is no character can mutate more than once in the whole tree. A main open problem regarding the model is finding generalizations that retain the computational tractability of the original model but are more flexible in modeling biological data when the infinite site assumption is violated because of e.g. back mutations. A special case of back mutations that has been considered in the study of the evolution of protein domains (where a domain is acquired and then lost) is persistency, that is the fact that a character is allowed to return back to the ancestral state. In this model characters can be gained and lost at most once. In this paper we consider the computational problem of explaining binary data by the Persistent Perfect Phylogeny model (referred as PPP) and for this purpose we investigate the problem of reconstructing an evolution where some constraints are imposed on the paths of the tree. Results We define a natural generalization of the PPP problem obtained by requiring that for some pairs (character, species), neither the species nor any of its ancestors can have the character. In other words, some characters cannot be persistent for some species. This new problem is called Constrained PPP (CPPP). Based on a graph formulation of the CPPP problem, we are able to provide a polynomial time solution for the CPPP problem for matrices whose conflict graph has no edges. Using this result, we develop a parameterized algorithm for solving the CPPP problem where the parameter is the number of characters. Conclusions A preliminary experimental analysis shows that the constrained persistent perfect phylogeny model allows to explain efficiently data that do not conform with the classical perfect phylogeny model. PMID:25572381

The gendered experience of stigmatization in severe and persistent mental illness in Lima, Peru.

PubMed

Robillard, Chantal

2010-12-01

Although power differentials which enable the components of stigma to unfold have been identified, literature that demonstrates the gendered disparities in stigmatization is scarce. Using a gender-based framework, this paper aims first at understanding the gendered social cues which produce the stigma in mental illness enacted by the general population. Second, it highlights the influence of gender on the everyday experiences of a severe and persistent mental illness and the related stigmatization. Results are drawn from a combination of ethnographic and qualitative methods including a field ethnography of two health centres, one psychiatric hospital, and participants' households and neighbourhoods, two group discussions with members of the general population participating in gender-specific social support groups (N = 12 women/5 men), and illness narratives of men and women with a severe and persistent mental illness (N = 22), which was conducted from May to August 2006 in a poor, urban district of Peru. It is argued that in a society like that of Peru where gender roles are segregated into specific social and economic fields, gendered expectations shape both the experience of a severe and persistent mental illness and the stigmatization of people with such a mental illness in a gender-specific way. Not only do gender inequalities create the conditions leading to a power differential which enables stigmatization to unfold, but stigma is constructed as much around gendered-defined social roles as it is enacted in distinct social spheres for men and women with a severe and persistent mental illness. The gendered experience of stigmatization must, therefore, be fully understood in order to design more effective interventions that would challenge stereotypical perceptions and discriminatory practices, and reduce their effect on the everyday life of the mentally ill in Peru. Copyright © 2010 Elsevier Ltd. All rights reserved.

Revisiting the natural history of tuberculosis. The inclusion of constant reinfection, host tolerance, and damage-response frameworks leads to a better understanding of latent infection and its evolution towards active disease.

PubMed

Cardona, Pere-Joan

2010-02-01

Once Mycobacterium tuberculosis infects a person it can persist for a long time in a process called latent tuberculosis infection (LTBI). LTBI has traditionally been considered to involve the bacilli remaining in a non-replicating state (dormant) in old lesions but still retaining their ability to induce reactivation and cause active tuberculosis (TB) once a disruption of the immune response takes place. The present review aims to challenge these concepts by including recent experimental data supporting LTBI as a constant endogenous reinfection process as well as the recently introduced concepts of damage-response and tolerance frameworks to explain TB induction. These frameworks highlight the key role of an exaggerated and intolerant host response against M. tuberculosis bacilli which induces the classical TB cavity in immunocompetent adults once the constant endogenous reinfection process has resulted in the presence of bacilli in the upper lobes, where they can grow faster and the immune response is delayed. This essay intends to provide new clues to understanding the induction of TB in non-immunosuppressed patients.

Modeling the Spread of Methicillin-Resistant Staphylococcus aureus in Nursing Homes for Elderly

PubMed Central

Chamchod, Farida; Ruan, Shigui

2012-01-01

Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in many hospital settings, including nursing homes. It is an important nosocomial pathogen that causes mortality and an economic burden to patients, hospitals, and the community. The epidemiology of the bacteria in nursing homes is both hospital- and community-like. Transmission occurs via hands of health care workers (HCWs) and direct contacts among residents during social activities. In this work, mathematical modeling in both deterministic and stochastic frameworks is used to study dissemination of MRSA among residents and HCWs, persistence and prevalence of MRSA in a population, and possible means of controlling the spread of this pathogen in nursing homes. The model predicts that: without strict screening and decolonization of colonized individuals at admission, MRSA may persist; decolonization of colonized residents, improving hand hygiene in both residents and HCWs, reducing the duration of contamination of HCWs, and decreasing the resident∶staff ratio are possible control strategies; the mean time that a resident remains susceptible since admission may be prolonged by screening and decolonization treatment in colonized individuals; in the stochastic framework, the total number of colonized residents varies and may increase when the admission of colonized residents, the duration of colonization, the average number of contacts among residents, or the average number of contacts that each resident requires from HCWs increases; an introduction of a colonized individual into an MRSA-free nursing home has a much higher probability of leading to a major outbreak taking off than an introduction of a contaminated HCW. PMID:22238650

Lack of access to health care for African indigents: a social exclusion perspective

PubMed Central

2013-01-01

Background Lack of access to health care is a persistent condition for most African indigents, to which the common technical approach of targeting initiatives is an insufficient antidote. To overcome the standstill, an integrated technical and political approach is needed. Such policy shift is dependent on political support, and on alignment of international and national actors. We explore if the analytical framework of social exclusion can contribute to the latter. Methods We produce a critical and evaluative account of the literature on three themes: social exclusion, development policy, and indigence in Africa–and their interface. First, we trace the concept of social exclusion as it evolved over time and space in policy circles. We then discuss the relevance of a social exclusion perspective in developing countries. Finally, we apply this perspective to Africa, its indigents, and their lack of access to health care. Results The concept of social exclusion as an underlying process of structural inequalities has needed two decades to find acceptance in international policy circles. Initial scepticism about the relevance of the concept in developing countries is now giving way to recognition of its universality. For a variety of reasons however, the uptake of a social exclusion perspective in Africa has been limited. Nevertheless, social exclusion as a driver of poverty and inequity in Africa is evident, and manifestly so in the case of the African indigents. Conclusion The concept of social exclusion provides a useful framework for improved understanding of origins and persistence of the access problem that African indigents face, and for generating political space for an integrated approach. PMID:24238000

Mapping Upper Amazon Palm Swamps with Spaceborne L-band Synthetic Aperture Radar

NASA Astrophysics Data System (ADS)

Pinto, N.; McDonald, K. C.; Podest, E.; Schroeder, R.; Zimmermann, R.; Horna, V.

2010-12-01

Palm swamp ecosystems are widespread in the Amazon basin, forming where seasonal flooding is moderate and surface inundation persists. Recent studies suggest that palm swamps have a disproportional role on tropical biogeochemistry: the combination of persistently saturated soils, warm temperatures, and low oxygen soils can support significant land-atmosphere methane flux. Potential impacts of climate change on these ecosystems include changes in temperature and precipitation regimes that influence primary productivity and flood extent significantly, potentially reversing net land-atmosphere carbon exchanges regionally. Data acquired from Earth-orbiting satellites provides the opportunity to characterize vegetation structure and monitor surface inundation independently of cloud cover. Building on efforts under our NASA MEaSUREs project for assembly of a global-scale Earth System Data Record (ESDR) of inundated wetlands, we develop and evaluate a systematic approach to map the distribution and composition of palm swamps in the upper Amazon using data sets from JAXA’s Advanced Land Observing Satellite (ALOS) Phased Array L-Band SAR (PALSAR). Our input dataset consists of HH backscatter images acquired in 2007 and 2009. Ground measurements for training were obtained from a study site near Loreto, Peru (4.43S 75.34W) containing the palm species Mauritia flexuosa. The ALOS PALSAR images are first averaged temporally and spatially. We then develop ancillary data layers of flood extent, distance from open water, and SAR image texture. The PALSAR data and derived ancillary layers are combined with MODIS Vegetation Indices and SRTM elevation and input in a classification framework. Since palm swamps are found in persistently flooded areas, we evaluate the potential of identifying and mapping these ecosystems using multi-temporal SAR-based flood extent maps. We conclude by comparing the performance between a decision-tree supervised vs. unsupervised approach and by quantifying model accuracy on a second site in Puerto Maldonado (12.38S 70.45W). This work has been undertaken in part within the framework of the JAXA ALOS Kyoto & Carbon Initiative. ALOS PALSAR data have been provided by JAXA EORC. This work was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

Comparison of different detection methods for persistent multiple hypothesis tracking in wide area motion imagery

NASA Astrophysics Data System (ADS)

Hartung, Christine; Spraul, Raphael; Schuchert, Tobias

2017-10-01

Wide area motion imagery (WAMI) acquired by an airborne multicamera sensor enables continuous monitoring of large urban areas. Each image can cover regions of several square kilometers and contain thousands of vehicles. Reliable vehicle tracking in this imagery is an important prerequisite for surveillance tasks, but remains challenging due to low frame rate and small object size. Most WAMI tracking approaches rely on moving object detections generated by frame differencing or background subtraction. These detection methods fail when objects slow down or stop. Recent approaches for persistent tracking compensate for missing motion detections by combining a detection-based tracker with a second tracker based on appearance or local context. In order to avoid the additional complexity introduced by combining two trackers, we employ an alternative single tracker framework that is based on multiple hypothesis tracking and recovers missing motion detections with a classifierbased detector. We integrate an appearance-based similarity measure, merge handling, vehicle-collision tests, and clutter handling to adapt the approach to the specific context of WAMI tracking. We apply the tracking framework on a region of interest of the publicly available WPAFB 2009 dataset for quantitative evaluation; a comparison to other persistent WAMI trackers demonstrates state of the art performance of the proposed approach. Furthermore, we analyze in detail the impact of different object detection methods and detector settings on the quality of the output tracking results. For this purpose, we choose four different motion-based detection methods that vary in detection performance and computation time to generate the input detections. As detector parameters can be adjusted to achieve different precision and recall performance, we combine each detection method with different detector settings that yield (1) high precision and low recall, (2) high recall and low precision, and (3) best f-score. Comparing the tracking performance achieved with all generated sets of input detections allows us to quantify the sensitivity of the tracker to different types of detector errors and to derive recommendations for detector and parameter choice.

Qualitative insights into practice time management: does 'patient-centred time' in practice management offer a portal to improved access?

PubMed

Buetow, S; Adair, V; Coster, G; Hight, M; Gribben, B; Mitchell, E

2002-12-01

Different sets of literature suggest how aspects of practice time management can limit access to general practitioner (GP) care. Researchers have not organised this knowledge into a unified framework that can enhance understanding of barriers to, and opportunities for, improved access. To suggest a framework conceptualising how differences in professional and cultural understanding of practice time management in Auckland, New Zealand, influence access to GP care for children with chronic asthma. A qualitative study involving selective sampling, semi-structured interviews on barriers to access, and a general inductive approach. Twenty-nine key informants and ten mothers of children with chronic, moderate to severe asthma and poor access to GP care in Auckland. Development of a framework from themes describing barriers associated with, and needs for, practice time management. The themes were independently identified by two authors from transcribed interviews and confirmed through informant checking. Themes from key informant and patient interviews were triangulated with each other and with published literature. The framework distinguishes 'practice-centred time' from 'patient-centred time.' A predominance of 'practice-centred time' and an unmet opportunity for 'patient-centred time' are suggested by the persistence of five barriers to accessing GP care: limited hours of opening; traditional appointment systems; practice intolerance of missed appointments; long waiting times in the practice; and inadequate consultation lengths. None of the barriers is specific to asthmatic children. A unified framework was suggested for understanding how the organisation of practice work time can influence access to GP care by groups including asthmatic children.

Capture of fixation by rotational flow; a deterministic hypothesis regarding scaling and stochasticity in fixational eye movements

PubMed Central

Wilkinson, Nicholas M.; Metta, Giorgio

2014-01-01

Visual scan paths exhibit complex, stochastic dynamics. Even during visual fixation, the eye is in constant motion. Fixational drift and tremor are thought to reflect fluctuations in the persistent neural activity of neural integrators in the oculomotor brainstem, which integrate sequences of transient saccadic velocity signals into a short term memory of eye position. Despite intensive research and much progress, the precise mechanisms by which oculomotor posture is maintained remain elusive. Drift exhibits a stochastic statistical profile which has been modeled using random walk formalisms. Tremor is widely dismissed as noise. Here we focus on the dynamical profile of fixational tremor, and argue that tremor may be a signal which usefully reflects the workings of oculomotor postural control. We identify signatures reminiscent of a certain flavor of transient neurodynamics; toric traveling waves which rotate around a central phase singularity. Spiral waves play an organizational role in dynamical systems at many scales throughout nature, though their potential functional role in brain activity remains a matter of educated speculation. Spiral waves have a repertoire of functionally interesting dynamical properties, including persistence, which suggest that they could in theory contribute to persistent neural activity in the oculomotor postural control system. Whilst speculative, the singularity hypothesis of oculomotor postural control implies testable predictions, and could provide the beginnings of an integrated dynamical framework for eye movements across scales. PMID:24616670

New Sexism in Couple Therapy: A Discursive Analysis.

PubMed

Sutherland, Olga; LaMarre, Andrea; Rice, Carla; Hardt, Laura; Le Couteur, Amanda

2017-09-01

The persistence of gender inequality in postindustrial societies is puzzling in light of a plethora of changes that destabilize it, including shifts in economy, legislation, and the proliferation of feminist politics. In family relations, such persistence manifests as a disconnect between couples aspiring to be more egalitarian yet continuing to enact traditional gender roles and hierarchies. There is an emerging consensus that gender inequality persists because of people's continued reliance on sexist ideology or gendered assumptions that constitute women as innately distinct from and inferior to men. Sexist ideology changes its form to accommodate to changing socio-economic conditions. Contemporary forms of sexism are old ways of legitimizing male power articulated in new and creative ways, often by incorporating feminist arguments. To effectively recognize and address "new sexism," scholars and practitioners require new, innovative research frameworks. Our objective in writing this article is two-fold. First, we seek to advance discursive (i.e., focused on language in use) approaches to the study of sexism. Second, we present the results of a discursive analysis of "new" sexist discourse in the context of couple therapy. The study provides preliminary evidence that, despite endorsing egalitarian norms, couples studied continue to rely on gender binaries and remain entrenched in old-fashioned patterns of gender inequality. Implications of these results for the practice of couple therapy and for future research are discussed. © 2017 Family Process Institute.

First genealogy for a wild marine fish population reveals multigenerational philopatry.

PubMed

Salles, Océane C; Pujol, Benoit; Maynard, Jeffrey A; Almany, Glenn R; Berumen, Michael L; Jones, Geoffrey P; Saenz-Agudelo, Pablo; Srinivasan, Maya; Thorrold, Simon R; Planes, Serge

2016-11-15

Natal philopatry, the return of individuals to their natal area for reproduction, has advantages and disadvantages for animal populations. Natal philopatry may generate local genetic adaptation, but it may also increase the probability of inbreeding that can compromise persistence. Although natal philopatry is well documented in anadromous fishes, marine fish may also return to their birth site to spawn. How philopatry shapes wild fish populations is, however, unclear because it requires constructing multigenerational pedigrees that are currently lacking for marine fishes. Here we present the first multigenerational pedigree for a marine fish population by repeatedly genotyping all individuals in a population of the orange clownfish (Amphiprion percula) at Kimbe Island (Papua New Guinea) during a 10-y period. Based on 2927 individuals, our pedigree analysis revealed that longitudinal philopatry was recurrent over five generations. Progeny tended to settle close to their parents, with related individuals often sharing the same colony. However, successful inbreeding was rare, and genetic diversity remained high, suggesting occasional inbreeding does not impair local population persistence. Local reproductive success was dependent on the habitat larvae settled into, rather than the habitat they came from. Our study suggests that longitudinal philopatry can influence both population replenishment and local adaptation of marine fishes. Resolving multigenerational pedigrees during a relatively short period, as we present here, provides a framework for assessing the ability of marine populations to persist and adapt to accelerating climate change.

First genealogy for a wild marine fish population reveals multigenerational philopatry

PubMed Central

Salles, Océane C.; Pujol, Benoit; Maynard, Jeffrey A.; Almany, Glenn R.; Berumen, Michael L.; Jones, Geoffrey P.; Saenz-Agudelo, Pablo; Srinivasan, Maya; Thorrold, Simon R.; Planes, Serge

2016-01-01

Natal philopatry, the return of individuals to their natal area for reproduction, has advantages and disadvantages for animal populations. Natal philopatry may generate local genetic adaptation, but it may also increase the probability of inbreeding that can compromise persistence. Although natal philopatry is well documented in anadromous fishes, marine fish may also return to their birth site to spawn. How philopatry shapes wild fish populations is, however, unclear because it requires constructing multigenerational pedigrees that are currently lacking for marine fishes. Here we present the first multigenerational pedigree for a marine fish population by repeatedly genotyping all individuals in a population of the orange clownfish (Amphiprion percula) at Kimbe Island (Papua New Guinea) during a 10-y period. Based on 2927 individuals, our pedigree analysis revealed that longitudinal philopatry was recurrent over five generations. Progeny tended to settle close to their parents, with related individuals often sharing the same colony. However, successful inbreeding was rare, and genetic diversity remained high, suggesting occasional inbreeding does not impair local population persistence. Local reproductive success was dependent on the habitat larvae settled into, rather than the habitat they came from. Our study suggests that longitudinal philopatry can influence both population replenishment and local adaptation of marine fishes. Resolving multigenerational pedigrees during a relatively short period, as we present here, provides a framework for assessing the ability of marine populations to persist and adapt to accelerating climate change. PMID:27799530

Combining paleo-data and modern exclosure experiments to assess the impact of megafauna extinctions on woody vegetation

PubMed Central

Bakker, Elisabeth S.; Gill, Jacquelyn L.; Johnson, Christopher N.; Vera, Frans W. M.; Sandom, Christopher J.; Asner, Gregory P.; Svenning, Jens-Christian

2016-01-01

Until recently in Earth history, very large herbivores (mammoths, ground sloths, diprotodons, and many others) occurred in most of the World’s terrestrial ecosystems, but the majority have gone extinct as part of the late-Quaternary extinctions. How has this large-scale removal of large herbivores affected landscape structure and ecosystem functioning? In this review, we combine paleo-data with information from modern exclosure experiments to assess the impact of large herbivores (and their disappearance) on woody species, landscape structure, and ecosystem functions. In modern landscapes characterized by intense herbivory, woody plants can persist by defending themselves or by association with defended species, can persist by growing in places that are physically inaccessible to herbivores, or can persist where high predator activity limits foraging by herbivores. At the landscape scale, different herbivore densities and assemblages may result in dynamic gradients in woody cover. The late-Quaternary extinctions were natural experiments in large-herbivore removal; the paleoecological record shows evidence of widespread changes in community composition and ecosystem structure and function, consistent with modern exclosure experiments. We propose a conceptual framework that describes the impact of large herbivores on woody plant abundance mediated by herbivore diversity and density, predicting that herbivore suppression of woody plants is strongest where herbivore diversity is high. We conclude that the decline of large herbivores induces major alterations in landscape structure and ecosystem functions. PMID:26504223

Combining paleo-data and modern exclosure experiments to assess the impact of megafauna extinctions on woody vegetation.

PubMed

Bakker, Elisabeth S; Gill, Jacquelyn L; Johnson, Christopher N; Vera, Frans W M; Sandom, Christopher J; Asner, Gregory P; Svenning, Jens-Christian

2016-01-26

Until recently in Earth history, very large herbivores (mammoths, ground sloths, diprotodons, and many others) occurred in most of the World's terrestrial ecosystems, but the majority have gone extinct as part of the late-Quaternary extinctions. How has this large-scale removal of large herbivores affected landscape structure and ecosystem functioning? In this review, we combine paleo-data with information from modern exclosure experiments to assess the impact of large herbivores (and their disappearance) on woody species, landscape structure, and ecosystem functions. In modern landscapes characterized by intense herbivory, woody plants can persist by defending themselves or by association with defended species, can persist by growing in places that are physically inaccessible to herbivores, or can persist where high predator activity limits foraging by herbivores. At the landscape scale, different herbivore densities and assemblages may result in dynamic gradients in woody cover. The late-Quaternary extinctions were natural experiments in large-herbivore removal; the paleoecological record shows evidence of widespread changes in community composition and ecosystem structure and function, consistent with modern exclosure experiments. We propose a conceptual framework that describes the impact of large herbivores on woody plant abundance mediated by herbivore diversity and density, predicting that herbivore suppression of woody plants is strongest where herbivore diversity is high. We conclude that the decline of large herbivores induces major alterations in landscape structure and ecosystem functions.

Relations between Vegetation and Geologic Framework in Barrier Island

NASA Astrophysics Data System (ADS)

Smart, N. H.; Ferguson, J. B.; Lehner, J. D.; Taylor, D.; Tuttle, L. F., II; Wernette, P. A.

2017-12-01

Barrier islands provide valuable ecosystems and protective services to coastal communities. The longevity of barrier islands is threatened by sea-level rise, human impacts, and extreme storms. The purpose of this research is to evaluate how vegetation dynamics interact with the subsurface and offshore framework geology to influence the beach and dune morphology. Beach and dune morphology can be viewed as free and/or forced behavior, where free systems are stochastic and the morphology is dependent on variations in the storm surge run-up, aeolian sediment supply and transport potential, and vegetation dynamics and persistence. Forced systems are those where patterns in the coastal morphology are determined by some other structural control, such as the underlying and offshore framework geology. Previous studies have documented the effects of geologic framework or vegetation dynamics on the beach and dunes, although none have examined possible control by vegetation dynamics in context of the geologic framework (i.e. combined free and forced behavior). Padre Island National Seashore (PAIS) was used to examine the interaction of free and forced morphology because the subsurface framework geology and surface beach and dune morphology are variable along the island. Vegetation dynamics were assessed by classifying geographically referenced historical aerial imagery into areas with vegetation and areas without vegetation, as well as LiDAR data to verify this imagery. The subsurface geologic structure was assessed using a combination of geophysical surveys (i.e. electromagnetic induction, ground-penetrating radar, and offshore seismic surveys). Comparison of the observed vegetation patterns and geologic framework leads to a series of questions surrounding how mechanistically these two drivers of coastal morphology are related. Upcoming coring and geophysical surveys will enable us to validate new and existing geophysical data. Results of this paper will help us better understand how barrier islands have responded to environmental change in the past should be integrated into current models of barrier island evolution in order to more accurately predict how the island will change over time in response to continued climatic variability.

Deriving persistence indicators from regulatory water-sediment studies – opportunities and limitations in OECD 308 data.

PubMed

Honti, Mark; Fenner, Kathrin

2015-05-19

The OECD guideline 308 describes a laboratory test method to assess aerobic and anaerobic transformation of organic chemicals in aquatic sediment systems and is an integral part of tiered testing strategies in different legislative frameworks for the environmental risk assessment of chemicals. The results from experiments carried out according to OECD 308 are generally used to derive persistence indicators for hazard assessment or half-lives for exposure assessment. We used Bayesian parameter estimation and system representations of various complexities to systematically assess opportunities and limitations for estimating these indicators from existing data generated according to OECD 308 for 23 pesticides and pharmaceuticals. We found that there is a disparity between the uncertainty and the conceptual robustness of persistence indicators. Disappearance half-lives are directly extractable with limited uncertainty, but they lump degradation and phase transfer information and are not robust against changes in system geometry. Transformation half-lives are less system-specific but require inverse modeling to extract, resulting in considerable uncertainty. Available data were thus insufficient to derive indicators that had both acceptable robustness and uncertainty, which further supports previously voiced concerns about the usability and efficiency of these costly experiments. Despite the limitations of existing data, we suggest the time until 50% of the parent compound has been transformed in the entire system (DegT(50,system)) could still be a useful indicator of persistence in the upper, partially aerobic sediment layer in the context of PBT assessment. This should, however, be accompanied by a mandatory reporting or full standardization of the geometry of the experimental system. We recommend transformation half-lives determined by inverse modeling to be used as input parameters into fate models for exposure assessment, if due consideration is given to their uncertainty.

A Longitudinal Investigation of Syndemic Conditions Among Young Gay, Bisexual, and Other MSM: The P18 Cohort Study.

PubMed

Halkitis, Perry N; Kapadia, Farzana; Bub, Kristen L; Barton, Staci; Moreira, Alvaro D; Stults, Christopher B

2015-06-01

The persistence of disparities in STI/HIV risk among a new generation of emerging adult gay, bisexual, and other men who have sex with men (YMSM) warrant holistic frameworks and new methodologies for investigating the behaviors related to STI/HIV in this group. In order to better understand the continued existence of these disparities in STI/HIV risk among YMSM, the present study evaluated the presence and persistence of syndemic conditions among YMSM by examining the co-occurrence of alcohol and drug use, unprotected sexual behavior, and mental health burden over time. Four waves of data, collected over the first 18 months of a 7 wave, 36-month prospective cohort study of YMSM (n=600) were used to examine the extent to which measurement models of drug use, unprotected sexual behavior, and mental health burden remained consistent across time using latent class modeling. Health challenges persisted across time as these YMSM emerged into young adulthood and the measurement models for the latent constructs of drug use and unprotected sexual behavior were essentially consistent across time whereas models for mental health burden varied over time. In addition to confirming the the robustness of our measurement models which capture a more holistic understandings of the health conditions of drug use, unprotected sex, and mental health burden, these findings underscore the ongoing health challenges YMSM face as they mature into young adulthood. These ongoing health challenges, which have been understood as forming a syndemic, persist over time, and add further evidence to support ongoing and vigilant comprehensive health programming for sexual minority men that move beyond a sole focus on HIV.

A longitudinal investigation of syndemic conditions among young gay, bisexual, and other MSM: The P18 Cohort Study

PubMed Central

Halkitis, Perry N.; Kapadia, Farzana; Bub, Kristen L.; Barton, Staci; Moreira, Alvaro D.; Stults, Christopher B.

2014-01-01

The persistence of disparities in STI/HIV risk among a new generation of emerging adult gay, bisexual, and other men who have sex with men (YMSM) warrant holistic frameworks and new methodologies for investigating the behaviors related to STI/HIV in this group. In order to better understand the continued existence of these disparities in STI/HIV risk among YMSM, the present study evaluated the presence and persistence of syndemic conditions among YMSM by examining the co-occurrence of alcohol and drug use, unprotected sexual behavior, and mental health burden over time. Four waves of data, collected over the first 18 months of a 7 wave, 36-month prospective cohort study of YMSM (n=598) were used to examine the extent to which measurement models of drug use, unprotected sexual behavior, and mental health burden remained consistent across time using latent class modeling. Health challenges persisted across time as these YMSM emerged into young adulthood and the measurement models for the latent constructs of drug use and unprotected sexual behavior were essentially consistent across time whereas models for mental health burden varied over time. In addition to confirming the the robustness of our measurement models which capture a more holistic understandings of the health conditions of drug use, unprotected sex, and mental health burden, these findings underscore the ongoing health challenges YMSM face as they mature into young adulthood. These ongoing health challenges, which have been understood as forming a syndemic, persist over time, and add further evidence to support ongoing and vigilant comprehensive health programming for sexual minority men that move beyond a sole focus on HIV. PMID:25192900

Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51.

PubMed

Sharma, Aruna; Muresanu, Dafin F; Lafuente, José Vicente; Sjöquist, Per-Ove; Patnaik, Ranjana; Ryan Tian, Z; Ozkizilcik, Asya; Sharma, Hari S

2018-01-01

The possibility that traumatic brain injury (TBI) occurring in a cold environment exacerbates brain pathology and oxidative stress was examined in our rat model. TBI was inflicted by making a longitudinal incision into the right parietal cerebral cortex (2 mm deep and 4 mm long) in cold-acclimatized rats (5 °C for 3 h daily for 5 weeks) or animals at room temperature under Equithesin anesthesia. TBI in cold-exposed rats exhibited pronounced increase in brain lucigenin (LCG), luminol (LUM), and malondialdehyde (MDA) and marked pronounced decrease in glutathione (GTH) as compared to identical TBI at room temperature. The magnitude and intensity of BBB breakdown to radioiodine and Evans blue albumin, edema formation, and neuronal injuries were also exacerbated in cold-exposed rats after injury as compared to room temperature. Nanowired delivery of H-290/51 (50 mg/kg) 6 and 8 h after injury in cold-exposed group significantly thwarted brain pathology and oxidative stress whereas normal delivery of H-290/51 was neuroprotective after TBI at room temperature only. These observations are the first to demonstrate that (i) cold aggravates the pathophysiology of TBI possibly due to an enhanced production of oxidative stress, (ii) and in such conditions, nanodelivery of antioxidant compound has superior neuroprotective effects, not reported earlier.

Genome editing: Bioethics shows the way.

PubMed

Neuhaus, Carolyn P; Caplan, Arthur L

2017-03-01

When some scientists hear the word "bioethics," they break out in intellectual hives. They shouldn't. Good bioethics is about enabling science to move forward. Bioethics pushes scientists to acknowledge that they operate not within a vacuum but within a society in which diverse perspectives and values must be engaged. Bioethicists give voice to those divergent perspectives and provide a framework to facilitate informed and inclusive discussions that spur progress, rather than stall it. The field is needed to advance cutting-edge biomedical research in domains in which the benefits to be had are enormous, such as genome editing, but ethical concerns persist.

Doctors, Lawyers and Advance Care Planning: Time for Innovation to Work Together to Meet Client Needs

PubMed Central

Douglas, Maureen; Simon, Jessica; Fassbender, Konrad

2016-01-01

Health organizations in Canada have invested considerable resources in strategies to improve knowledge and uptake of advance care planning (ACP). Yet barriers persist and many Canadians do not engage in the full range of ACP behaviours, including writing an advance directive and appointing a legally authorized decision-maker. Not engaging effectively in ACP disadvantages patients, their loved ones and their healthcare providers. This article advocates for greater collaboration between health and legal professionals to better support clients in ACP and presents a framework for action to build connections between these typically siloed professions. PMID:28032821

Practical Framework for an Electron Beam Induced Current Technique Based on a Numerical Optimization Approach

NASA Astrophysics Data System (ADS)

Yamaguchi, Hideshi; Soeda, Takeshi

2015-03-01

A practical framework for an electron beam induced current (EBIC) technique has been established for conductive materials based on a numerical optimization approach. Although the conventional EBIC technique is useful for evaluating the distributions of dopants or crystal defects in semiconductor transistors, issues related to the reproducibility and quantitative capability of measurements using this technique persist. For instance, it is difficult to acquire high-quality EBIC images throughout continuous tests due to variation in operator skill or test environment. Recently, due to the evaluation of EBIC equipment performance and the numerical optimization of equipment items, the constant acquisition of high contrast images has become possible, improving the reproducibility as well as yield regardless of operator skill or test environment. The technique proposed herein is even more sensitive and quantitative than scanning probe microscopy, an imaging technique that can possibly damage the sample. The new technique is expected to benefit the electrical evaluation of fragile or soft materials along with LSI materials.

The influence of stress responses on surgical performance and outcomes: Literature review and the development of the surgical stress effects (SSE) framework.

PubMed

Chrouser, Kristin L; Xu, Jie; Hallbeck, Susan; Weinger, Matthew B; Partin, Melissa R

2018-02-22

Surgical adverse events persist despite several decades of system-based quality improvement efforts, suggesting the need for alternative strategies. Qualitative studies suggest stress-induced negative intraoperative interpersonal dynamics might contribute to performance errors and undesirable patient outcomes. Understanding the impact of intraoperative stressors may be critical to reducing adverse events and improving outcomes. We searched MEDLINE, psycINFO, EMBASE, Business Source Premier, and CINAHL databases (1996-2016) to assess the relationship between negative (emotional and behavioral) responses to acute intraoperative stressors and provider performance or patient surgical outcomes. Drawing on theory and evidence from reviewed studies, we present the Surgical Stress Effects (SSE) framework. This illustrates how emotional and behavioral responses to stressors can influence individual surgical provider (e.g. surgeon, nurse) performance, team performance, and patient outcomes. It also demonstrates how uncompensated intraoperative threats and errors can lead to adverse events, highlighting evidence gaps for future research efforts. Published by Elsevier Inc.

Emission Inventory for PFOS in China: Review of Past Methodologies and Suggestions

PubMed Central

Lim, Theodore Chao; Wang, Bin; Huang, Jun; Deng, Shubo; Yu, Gang

2011-01-01

Perfluorooctane sulfonate (PFOS) is a persistent, bioaccumulative, and toxic chemical that has the potential for long-range transport in the environment. Its use in a wide variety of consumer products and industrial processes makes a detailed characterization of its emissions sources very challenging. These varied emissions sources all contribute to PFOS' existence within nearly all environmental media. Currently, China is the only country documented to still be producing PFOS, though there is no China PFOS emission inventory available. This study reviews the inventory methodologies for PFOS in other countries to suggest a China-specific methodology framework for a PFOS emission inventory. The suggested framework combines unknowns for PFOS-containing product penetration into the Chinese market with product lifecycle assumptions, centralizing these diverse sources into municipal sewage treatment plants. Releases from industrial sources can be quantified separately using another set of emission factors. Industrial sources likely to be relevant to the Chinese environment are identified. PMID:22125449

On the causes of early life experience effects: evaluating the role of mom.

PubMed

Tang, Akaysha C; Reeb-Sutherland, Bethany C; Romeo, Russell D; McEwen, Bruce S

2014-04-01

Early life experiences are thought to have long-lasting effects on cognitive, emotional, and social function during adulthood. Changes in neuroendocrine function, particularly the hypothalamic-pituitary-adrenal (HPA) axis, contribute to these systems-level behavioral effects. In searching for causal mechanisms underlying these early experience effects, pioneering research has demonstrated an important role for maternal care in offspring development, and this has led to two persistent ideas that permeate current research and thinking: first, environmental impact on the developing infant is mediated through maternal care behavior; second, the more care that a mother provides, the better off her offspring. While a good beginning, the reality is likely more complex. In this review, we critically examine these ideas and propose a computationally-motivated theoretical framework, and within this framework, we consider evidence supporting a hypothesis of maternal modulation. These findings may inform policy decisions in the context of child health and development. Copyright © 2013 Elsevier Inc. All rights reserved.

The default mode network and recurrent depression: a neurobiological model of cognitive risk factors.

PubMed

Marchetti, Igor; Koster, Ernst H W; Sonuga-Barke, Edmund J; De Raedt, Rudi

2012-09-01

A neurobiological account of cognitive vulnerability for recurrent depression is presented based on recent developments of resting state neural networks. We propose that alterations in the interplay between task positive (TP) and task negative (TN) elements of the Default Mode Network (DMN) act as a neurobiological risk factor for recurrent depression mediated by cognitive mechanisms. In the framework, depression is characterized by an imbalance between TN-TP components leading to an overpowering of TP by TN activity. The TN-TP imbalance is associated with a dysfunctional internally-focused cognitive style as well as a failure to attenuate TN activity in the transition from rest to task. Thus we propose the TN-TP imbalance as overarching neural mechanism involved in crucial cognitive risk factors for recurrent depression, namely rumination, impaired attentional control, and cognitive reactivity. During remission the TN-TP imbalance persists predisposing to vulnerability of recurrent depression. Empirical data to support this model is reviewed. Finally, we specify how this framework can guide future research efforts.

A mathematical study of a model for childhood diseases with non-permanent immunity

NASA Astrophysics Data System (ADS)

Moghadas, S. M.; Gumel, A. B.

2003-08-01

Protecting children from diseases that can be prevented by vaccination is a primary goal of health administrators. Since vaccination is considered to be the most effective strategy against childhood diseases, the development of a framework that would predict the optimal vaccine coverage level needed to prevent the spread of these diseases is crucial. This paper provides this framework via qualitative and quantitative analysis of a deterministic mathematical model for the transmission dynamics of a childhood disease in the presence of a preventive vaccine that may wane over time. Using global stability analysis of the model, based on constructing a Lyapunov function, it is shown that the disease can be eradicated from the population if the vaccination coverage level exceeds a certain threshold value. It is also shown that the disease will persist within the population if the coverage level is below this threshold. These results are verified numerically by constructing, and then simulating, a robust semi-explicit second-order finite-difference method.

Childbearing, stress and obesity disparities in women: a public health perspective

PubMed Central

Davis, Esa M; Stange, Kurt C; Horwitz, Ralph I

2011-01-01

The perinatal period, from early in the first trimester to 1 year postpartum, provides opportunities for novel public health interventions to reduce obesity disparities. We present a unifying socio-biological framework to suggest opportunities for multidisciplinary research and public health approaches to elucidate and target the mechanisms for the development of maternal obesity and related disparities. The framework illustrates the interplay of the social, cultural and physical environment; stress appraisal and response; and coping behaviors on short-term outcomes (e.g. allostatic load and gestational weight gain), the intermediate outcomes of persistent insulin resistance and post-partum weight retention, and longer term outcomes of obesity and its disease consequences. Testing the proposed relationships may provide insights into how childbearing risk factors such as gestational weight gain, postpartum weight retention and parity contribute to obesity, which are needed to inform public health policies and clinical care guidelines aimed at reducing obesity and improving the health of women. PMID:21088987

Monitoring sanitation and hygiene in the 2030 Agenda for Sustainable Development: A review through the lens of human rights.

PubMed

Giné-Garriga, Ricard; Flores-Baquero, Óscar; Jiménez-Fdez de Palencia, Alejandro; Pérez-Foguet, Agustí

2017-02-15

International monitoring of drinking water and sanitation has been jointly carried out by WHO and UNICEF through their Joint Monitoring Programme (JMP). With the end of the Millennium Development Goals (MDGs) era in 2015, the JMP has proposed a post-2015 framework for integrated monitoring of water and sanitation targets included in the Sustainable Development Goal no. 6. This article discusses how each element of the proposed sanitation target and corresponding indicators can be understood from a human rights perspective. Building on the MDGs, and although some of the weaknesses and gaps persist, the discussion suggests that the post-2015 proposal is a step forward towards a monitoring framework where human rights elements related to sanitation are effectively promoted. In addition, to support the interpretation and implementation of the normative content of human rights obligations related to sanitation, the study proposes a reduced set of easy-to-assess indicators to measure the normative criteria of this right, which are then grouped in a multidimensional framework to describe increasing levels of sanitation service. To do this, the study combines literature review and specific local experience from three case studies. It is shown that the proposed monitoring tools, namely the indicators and the multidimensional indicator framework, provide guidance on monitoring the human right to sanitation. In doing so, they might ultimately help sector stakeholders in the realization of this right. Copyright © 2016 Elsevier B.V. All rights reserved.

Persistence of viral infection despite similar killing efficacy of antiviral CD8(+) T cells during acute and chronic phases of infection.

PubMed

Ganusov, Vitaly V; Lukacher, Aron E; Byers, Anthony M

2010-09-15

Why some viruses establish chronic infections while others do not is poorly understood. One possibility is that the host's immune response is impaired during chronic infections and is unable to clear the virus from the host. In this report, we use a recently proposed framework to estimate the per capita killing efficacy of CD8(+) T cells, specific for the polyoma virus (PyV), which establishes a chronic infection in mice. Surprisingly, the estimated per cell killing efficacy of PyV-specific effector CD8(+) T cells during the acute phase of the infection was very similar to the efficacy of effector CD8(+) T cells specific to lymphocytic choriomeningitis virus (LCMV-Armstrong), which is cleared from the host. Our results suggest that persistence of PyV does not result from the generation of an inefficient PyV-specific CD8(+) T cell response, and that other host or viral factors are responsible for the ability of PyV to establish chronic infection. Copyright 2010 Elsevier Inc. All rights reserved.

The natural history of substance use disorders.

PubMed

Sarvet, Aaron L; Hasin, Deborah

2016-07-01

Illicit drugs, alcohol, and tobacco use disorders contribute substantially to the global burden of disease. Knowledge about the major elements of the natural history of substance use disorders (incidence, remission, persistence, and relapse) is crucial to a broader understanding of the course and outcomes of substance use disorders. Prospective cohort studies in nonclinical samples indicate that externalizing psychopathology in earlier life, including early disordered substance use, delinquency, and personality disorders, are related to substance use disorders later in life and chronic course. Externalizing psychopathology may be initiated by early adverse experiences, for example, childhood maltreatment and stressful life events. After controlling for confounders, 'age at first use' as a causal factor for alcohol use disorder later in life and the 'drug substitution' hypothesis are not supported in general population data. Future research should focus on elaborating the causal framework that leads to the development and persistence of severe substance use disorders, with an emphasis on identifying modifiable factors for intervention by policy makers or health professionals. More research is needed on the natural history of substance use disorders in low-income and middle-income countries.

Theorizing Race and Racism: Preliminary Reflections on the Medical Curriculum.

PubMed

Braun, Lundy

2017-05-01

The current political economic crisis in the United States places in sharp relief the tensions and contradictions of racial capitalism as it manifests materially in health care and in knowledge-producing practices. Despite nearly two decades of investment in research on racial inequality in disease, inequality persists. While the reasons for persistence of inequality are manifold, little attention has been directed to the role of medical education. Importantly, medical education has failed to foster critical theorizing on race and racism to illuminate the often-invisible ways in which race and racism shape biomedical knowledge and clinical practice. Medical students across the nation are advocating for more critical anti-racist education that centers the perspectives and knowledge of marginalized communities. This Article examines the contemporary resurgence in explicit forms of white supremacy in light of growing student activism and research that privileges notions of innate differences between races. It calls for a theoretical framework that draws on Critical Race Theory and the Black Radical Tradition to interrogate epistemological practices and advocacy initiatives in medical education.

Persistent electrochemical performance in epitaxial VO 2(B)

DOE PAGES

Lee, Shinbuhm; Sun, Xiao -Guang; Lubimtsev, Andrew A.; ...

2017-03-07

Discovering high-performance energy storage materials is indispensable for renewable energy, electric vehicle performance, and mobile computing. Owing to the open atomic framework and good room temperature conductivity, bronze-phase vanadium dioxide [VO 2(B)] has been regarded as a highly promising electrode material for Li ion batteries. However, previous attempts were unsuccessful to show the desired cycling performance and capacity without chemical modification. Here, we show with epitaxial VO 2(B) films that one can accomplish the theoretical limit for capacity with persistent charging–discharging cyclability owing to the high structural stability and unique open pathways for Li ion conduction. Atomic-scale characterization by scanningmore » transmission electron microscopy and density functional theory calculations also reveal that the unique open pathways in VO 2(B) provide the most stable sites for Li adsorption and diffusion. Furthermore, this work ultimately demonstrates that VO 2(B) is a highly promising energy storage material and has no intrinsic hindrance in achieving superior cyclability with a very high power and capacity in a Li-ion conductor.« less

Mixed state dynamical quantum phase transitions

NASA Astrophysics Data System (ADS)

Bhattacharya, Utso; Bandyopadhyay, Souvik; Dutta, Amit

2017-11-01

Preparing an integrable system in a mixed state described by a thermal density matrix, we subject it to a sudden quench and explore the subsequent unitary dynamics. To address the question of whether the nonanalyticities, namely, the dynamical quantum phase transitions (DQPTs), persist when the initial state is mixed, we consider two versions of the generalized Loschmidt overlap amplitude (GLOA). Our study shows that the GLOA constructed using the Uhlmann approach does not show any signature of DQPTs at any nonzero initial temperature. On the other hand, a GLOA defined in the interferometric phase approach through the purifications of the time-evolved density matrix, indeed shows that nonanalyiticies in the corresponding "dynamical free-energy density" persist, thereby establishing the existence of mixed state dynamical quantum phase transitions (MSDQPTs). Our work provides a framework that perfectly reproduces both the nonanalyticities and also the emergent topological structure in the pure state limit. These claims are corroborated by analyzing the nonequilibrium dynamics of a transverse Ising chain initially prepared in a thermal state and subjected to a sudden quench of the transverse field.

Maintaining activity engagement: individual differences in the process of self-regulating motivation.

PubMed

Sansone, Carol; Thoman, Dustin B

2006-12-01

Typically, models of self-regulation include motivation in terms of goals. Motivation is proposed to differ among individuals as a consequence of the goals they hold as well as how much they value those goals and expect to attain them. We suggest that goal-defined motivation is only one source of motivation critical for sustained engagement. A second source is the motivation that arises from the degree of interest experienced in the process of goal pursuit. Our model integrates both sources of motivation within the goal-striving process and suggests that individuals may actively monitor and regulate them. Conceptualizing motivation in terms of a self-regulatory process provides an organizing framework for understanding how individuals might differ in whether they experience interest while working toward goals, whether they persist without interest, and whether and how they try to create interest. We first present the self-regulation of motivation model and then review research illustrating how the consideration of individual differences at different points in the process allows a better understanding of variability in people's choices, efforts, and persistence over time.

Social cycling and conditional responses in the Rock-Paper-Scissors game

PubMed Central

Wang, Zhijian; Xu, Bin; Zhou, Hai-Jun

2014-01-01

How humans make decisions in non-cooperative strategic interactions is a big question. For the fundamental Rock-Paper-Scissors (RPS) model game system, classic Nash equilibrium (NE) theory predicts that players randomize completely their action choices to avoid being exploited, while evolutionary game theory of bounded rationality in general predicts persistent cyclic motions, especially in finite populations. However as empirical studies have been relatively sparse, it is still a controversial issue as to which theoretical framework is more appropriate to describe decision-making of human subjects. Here we observe population-level persistent cyclic motions in a laboratory experiment of the discrete-time iterated RPS game under the traditional random pairwise-matching protocol. This collective behavior contradicts with the NE theory but is quantitatively explained, without any adjustable parameter, by a microscopic model of win-lose-tie conditional response. Theoretical calculations suggest that if all players adopt the same optimized conditional response strategy, their accumulated payoff will be much higher than the reference value of the NE mixed strategy. Our work demonstrates the feasibility of understanding human competition behaviors from the angle of non-equilibrium statistical physics. PMID:25060115

Qualitative insights into practice time management: does 'patient-centred time' in practice management offer a portal to improved access?

PubMed Central

Buetow, S; Adair, V; Coster, G; Hight, M; Gribben, B; Mitchell, E

2002-01-01

BACKGROUND: Different sets of literature suggest how aspects of practice time management can limit access to general practitioner (GP) care. Researchers have not organised this knowledge into a unified framework that can enhance understanding of barriers to, and opportunities for, improved access. AIM: To suggest a framework conceptualising how differences in professional and cultural understanding of practice time management in Auckland, New Zealand, influence access to GP care for children with chronic asthma. DESIGN OF STUDY: A qualitative study involving selective sampling, semi-structured interviews on barriers to access, and a general inductive approach. SETTING: Twenty-nine key informants and ten mothers of children with chronic, moderate to severe asthma and poor access to GP care in Auckland. METHOD: Development of a framework from themes describing barriers associated with, and needs for, practice time management. The themes were independently identified by two authors from transcribed interviews and confirmed through informant checking. Themes from key informant and patient interviews were triangulated with each other and with published literature. RESULTS: The framework distinguishes 'practice-centred time' from 'patient-centred time.' A predominance of 'practice-centred time' and an unmet opportunity for 'patient-centred time' are suggested by the persistence of five barriers to accessing GP care: limited hours of opening; traditional appointment systems; practice intolerance of missed appointments; long waiting times in the practice; and inadequate consultation lengths. None of the barriers is specific to asthmatic children. CONCLUSION: A unified framework was suggested for understanding how the organisation of practice work time can influence access to GP care by groups including asthmatic children. PMID:12528583

Flow motifs reveal limitations of the static framework to represent human interactions

NASA Astrophysics Data System (ADS)

Rocha, Luis E. C.; Blondel, Vincent D.

2013-04-01

Networks are commonly used to define underlying interaction structures where infections, information, or other quantities may spread. Although the standard approach has been to aggregate all links into a static structure, some studies have shown that the time order in which the links are established may alter the dynamics of spreading. In this paper, we study the impact of the time ordering in the limits of flow on various empirical temporal networks. By using a random walk dynamics, we estimate the flow on links and convert the original undirected network (temporal and static) into a directed flow network. We then introduce the concept of flow motifs and quantify the divergence in the representativity of motifs when using the temporal and static frameworks. We find that the regularity of contacts and persistence of vertices (common in email communication and face-to-face interactions) result on little differences in the limits of flow for both frameworks. On the other hand, in the case of communication within a dating site and of a sexual network, the flow between vertices changes significantly in the temporal framework such that the static approximation poorly represents the structure of contacts. We have also observed that cliques with 3 and 4 vertices containing only low-flow links are more represented than the same cliques with all high-flow links. The representativity of these low-flow cliques is higher in the temporal framework. Our results suggest that the flow between vertices connected in cliques depend on the topological context in which they are placed and in the time sequence in which the links are established. The structure of the clique alone does not completely characterize the potential of flow between the vertices.

Ecological opportunity and the adaptive diversification of lineages

PubMed Central

Wellborn, Gary A; Langerhans, R Brian

2015-01-01

The tenet that ecological opportunity drives adaptive diversification has been central to theories of speciation since Darwin, yet no widely accepted definition or mechanistic framework for the concept currently exists. We propose a definition for ecological opportunity that provides an explicit mechanism for its action. In our formulation, ecological opportunity refers to environmental conditions that both permit the persistence of a lineage within a community, as well as generate divergent natural selection within that lineage. Thus, ecological opportunity arises from two fundamental elements: (1) niche availability, the ability of a population with a phenotype previously absent from a community to persist within that community and (2) niche discordance, the diversifying selection generated by the adaptive mismatch between a population's niche-related traits and the newly encountered ecological conditions. Evolutionary response to ecological opportunity is primarily governed by (1) spatiotemporal structure of ecological opportunity, which influences dynamics of selection and development of reproductive isolation and (2) diversification potential, the biological properties of a lineage that determine its capacity to diversify. Diversification under ecological opportunity proceeds as an increase in niche breadth, development of intraspecific ecotypes, speciation, and additional cycles of diversification that may themselves be triggered by speciation. Extensive ecological opportunity may exist in depauperate communities, but it is unclear whether ecological opportunity abates in species-rich communities. Because ecological opportunity should generally increase during times of rapid and multifarious environmental change, human activities may currently be generating elevated ecological opportunity – but so far little work has directly addressed this topic. Our framework highlights the need for greater synthesis of community ecology and evolutionary biology, unifying the four major components of the concept of ecological opportunity. PMID:25628875

Ecological opportunity and the adaptive diversification of lineages.

PubMed

Wellborn, Gary A; Langerhans, R Brian

2015-01-01

The tenet that ecological opportunity drives adaptive diversification has been central to theories of speciation since Darwin, yet no widely accepted definition or mechanistic framework for the concept currently exists. We propose a definition for ecological opportunity that provides an explicit mechanism for its action. In our formulation, ecological opportunity refers to environmental conditions that both permit the persistence of a lineage within a community, as well as generate divergent natural selection within that lineage. Thus, ecological opportunity arises from two fundamental elements: (1) niche availability, the ability of a population with a phenotype previously absent from a community to persist within that community and (2) niche discordance, the diversifying selection generated by the adaptive mismatch between a population's niche-related traits and the newly encountered ecological conditions. Evolutionary response to ecological opportunity is primarily governed by (1) spatiotemporal structure of ecological opportunity, which influences dynamics of selection and development of reproductive isolation and (2) diversification potential, the biological properties of a lineage that determine its capacity to diversify. Diversification under ecological opportunity proceeds as an increase in niche breadth, development of intraspecific ecotypes, speciation, and additional cycles of diversification that may themselves be triggered by speciation. Extensive ecological opportunity may exist in depauperate communities, but it is unclear whether ecological opportunity abates in species-rich communities. Because ecological opportunity should generally increase during times of rapid and multifarious environmental change, human activities may currently be generating elevated ecological opportunity - but so far little work has directly addressed this topic. Our framework highlights the need for greater synthesis of community ecology and evolutionary biology, unifying the four major components of the concept of ecological opportunity.

The Pan-University Network for Global Health: framework for collaboration and review of global health needs.

PubMed

Winchester, M S; BeLue, R; Oni, T; Wittwer-Backofen, U; Deobagkar, D; Onya, H; Samuels, T A; Matthews, S A; Stone, C; Airhihenbuwa, C

2016-04-21

In the current United Nations efforts to plan for post 2015-Millennium Development Goals, global partnership to address non-communicable diseases (NCDs) has become a critical goal to effectively respond to the complex global challenges of which inequity in health remains a persistent challenge. Building capacity in terms of well-equipped local researchers and service providers is a key to bridging the inequity in global health. Launched by Penn State University in 2014, the Pan University Network for Global Health responds to this need by bridging researchers at more than 10 universities across the globe. In this paper we outline our framework for international and interdisciplinary collaboration, as well the rationale for our research areas, including a review of these two themes. After its initial meeting, the network has established two central thematic priorities: 1) urbanization and health and 2) the intersection of infectious diseases and NCDs. The urban population in the global south will nearly double in 25 years (approx. 2 billion today to over 3.5 billion by 2040). Urban population growth will have a direct impact on global health, and this growth will be burdened with uneven development and the persistence of urban spatial inequality, including health disparities. The NCD burden, which includes conditions such as hypertension, stroke, and diabetes, is outstripping infectious disease in countries in the global south that are considered to be disproportionately burdened by infectious diseases. Addressing these two priorities demands an interdisciplinary and multi-institutional model to stimulate innovation and synergy that will influence the overall framing of research questions as well as the integration and coordination of research.

Metal organic framework Cu9Cl2(cpa)6 as tunable molecular magnet

NASA Astrophysics Data System (ADS)

Hamilton, Heather S. C.; Farmer, William M.; Skinner, Samuel F.; ter Haar, Leonard W.

2018-05-01

Chemical modifications of the magnetic metal organic framework (MOF) Cu9X2(cpa)6.42H2O (X = F, Cl, Br; cpa = anion of 2-carboxypentonicacid) have been investigated as a means of modifying, in a tunable manner, the magnetism of this 2-D material best described as a triangles-in-triangles (TIT) or triangulated-Kagomé-latttice (TKL). Since numerous theoretical studies have already attempted to describe the enigmatic ground state of this Heisenberg lattice, tunable chemical modifications should provide an excellent opportunity to expand this class of materials for studies concerning fundamental physics of frustrated spins, and applications such as adiabatic demagnetization refrigeration (ADR) that depend on the magnetocaloric effect (MCE). The chemical modification investigated is the intercalation of d- and f-orbital ions into the voids of the framework (channels of nearly 20 Å diameter). Magnetic measurements in the temperature range 1.8 - 300 K confirm signature features of TKL magnetism in intercalated samples persist, specifically: i) large negative Weiss constant (θCW); ii) absence of a phase transition down to 1.8 K; iii) minimum in χMT; iv) low temperature χMT values increasingly divergent at low fields indicating net ferromagnetic correlations; and, v) increasing field dependence of magnetization at low temperatures suggestive of intermediate plateaus, or ferrimagnetism, not saturation.

Using the Biology Card Sorting Task to Measure Changes in Conceptual Expertise during Postsecondary Biology Education

PubMed Central

Bissonnette, Sarah A.; Combs, Elijah D.; Nagami, Paul H.; Byers, Victor; Fernandez, Juliana; Le, Dinh; Realin, Jared; Woodham, Selina; Smith, Julia I.; Tanner, Kimberly D.

2017-01-01

While there have been concerted efforts to reform undergraduate biology toward teaching students to organize their conceptual knowledge like experts, there are few tools that attempt to measure this. We previously developed the Biology Card Sorting Task (BCST), designed to probe how individuals organize their conceptual biological knowledge. Previous results showed the BCST could differentiate between different populations, namely non–biology majors (NBM) and biology faculty (BF). In this study, we administered the BCST to three additional populations, using a cross-sectional design: entering biology majors (EBM), advanced biology majors (ABM), and biology graduate students (BGS). Intriguingly, ABM did not initially sort like experts any more frequently than EBM. However, once the deep-feature framework was revealed, ABM were able to sort like experts more readily than did EBM. These results are consistent with the conclusion that biology education enables advanced biology students to use an expert-like conceptual framework. However, these results are also consistent with a process of “selection,” wherein students who persist in the major may have already had an expert-like conceptual framework to begin with. These results demonstrate the utility of the BCST in measuring differences between groups of students over the course of their undergraduate education. PMID:28213584

Role of natural attenuation in modeling the leaching of contaminants in the risk analysis framework.

PubMed

Verginelli, Iason; Baciocchi, Renato

2013-01-15

Natural attenuation (NA) processes occurring in the subsurface can significantly affect the impact on groundwater from contamination sources located in the vadose zone, especially when mobile and readily biodegradable compounds, such as BTEX, are present. Besides, in the last decades several studies have shown natural attenuation to take place also for more persistent compounds, such as Polycyclic Aromatic Hydrocarbons (PAHs). Nevertheless, common risk analysis frameworks, based on the ASTM RBCA (Risk Based Corrective Action) approach, do not include NA pathways in the fate and transport models, thus possibly leading to an overestimation of the calculated risk. The aim of this study was to provide an insight on the relevance of the different key natural attenuation processes usually taking place in the subsurface and to highlight for which contamination scenarios their inclusion in the risk-analysis framework could provide a more realistic risk assessment. To this end, an analytical model accounting for source depletion and biodegradation, dispersion and diffusion during leaching was developed and applied to several contamination scenarios. These scenarios included contamination by BTEX, characterized by relatively high mobility and biodegradation rate, and PAHs, i.e. a more persistent class of compounds. The obtained results showed that BTEX are likely to be attenuated in the source zone due to their mobility and ready biodegradation (assuming biodegradation constant rates in the order of 0.01-1 d(-1)). Instead, attenuation along transport through the vadose zone was found to be less important, as the residence time of the contaminant in the unsaturated zone is often too low with respect to the time required to get a relevant biodegradation of BTEX. On the other hand, heavier compounds such as PAHs, were found to be attenuated during leaching since the residence time in the vadose zone can reach values up to thousands of years. In these cases, even with the relatively slow biodegradation rate of PAHs, in the order of 0.0001-0.001 d(-1), attenuation can result significant. These conclusions were also confirmed by comparing the model results with experimental data collected at an hydrocarbon-contaminated site. The proposed model, that neglects the transport of NAPLs, could be easily included in the risk-analysis framework, allowing to get a more realistic assessment of risks, while keeping the intrinsic simplicity of the ASTM-RBCA approach. Copyright © 2012 Elsevier Ltd. All rights reserved.

Achieving human and machine accessibility of cited data in scholarly publications

PubMed Central

Starr, Joan; Castro, Eleni; Crosas, Mercè; Dumontier, Michel; Downs, Robert R.; Duerr, Ruth; Haak, Laurel L.; Haendel, Melissa; Herman, Ivan; Hodson, Simon; Hourclé, Joe; Kratz, John Ernest; Lin, Jennifer; Nielsen, Lars Holm; Nurnberger, Amy; Proell, Stefan; Rauber, Andreas; Sacchi, Simone; Smith, Arthur; Taylor, Mike; Clark, Tim

2015-01-01

Reproducibility and reusability of research results is an important concern in scientific communication and science policy. A foundational element of reproducibility and reusability is the open and persistently available presentation of research data. However, many common approaches for primary data publication in use today do not achieve sufficient long-term robustness, openness, accessibility or uniformity. Nor do they permit comprehensive exploitation by modern Web technologies. This has led to several authoritative studies recommending uniform direct citation of data archived in persistent repositories. Data are to be considered as first-class scholarly objects, and treated similarly in many ways to cited and archived scientific and scholarly literature. Here we briefly review the most current and widely agreed set of principle-based recommendations for scholarly data citation, the Joint Declaration of Data Citation Principles (JDDCP). We then present a framework for operationalizing the JDDCP; and a set of initial recommendations on identifier schemes, identifier resolution behavior, required metadata elements, and best practices for realizing programmatic machine actionability of cited data. The main target audience for the common implementation guidelines in this article consists of publishers, scholarly organizations, and persistent data repositories, including technical staff members in these organizations. But ordinary researchers can also benefit from these recommendations. The guidance provided here is intended to help achieve widespread, uniform human and machine accessibility of deposited data, in support of significantly improved verification, validation, reproducibility and re-use of scholarly/scientific data. PMID:26167542

Achieving human and machine accessibility of cited data in scholarly publications.

PubMed

Starr, Joan; Castro, Eleni; Crosas, Mercè; Dumontier, Michel; Downs, Robert R; Duerr, Ruth; Haak, Laurel L; Haendel, Melissa; Herman, Ivan; Hodson, Simon; Hourclé, Joe; Kratz, John Ernest; Lin, Jennifer; Nielsen, Lars Holm; Nurnberger, Amy; Proell, Stefan; Rauber, Andreas; Sacchi, Simone; Smith, Arthur; Taylor, Mike; Clark, Tim

Reproducibility and reusability of research results is an important concern in scientific communication and science policy. A foundational element of reproducibility and reusability is the open and persistently available presentation of research data. However, many common approaches for primary data publication in use today do not achieve sufficient long-term robustness, openness, accessibility or uniformity. Nor do they permit comprehensive exploitation by modern Web technologies. This has led to several authoritative studies recommending uniform direct citation of data archived in persistent repositories. Data are to be considered as first-class scholarly objects, and treated similarly in many ways to cited and archived scientific and scholarly literature. Here we briefly review the most current and widely agreed set of principle-based recommendations for scholarly data citation, the Joint Declaration of Data Citation Principles (JDDCP). We then present a framework for operationalizing the JDDCP; and a set of initial recommendations on identifier schemes, identifier resolution behavior, required metadata elements, and best practices for realizing programmatic machine actionability of cited data. The main target audience for the common implementation guidelines in this article consists of publishers, scholarly organizations, and persistent data repositories, including technical staff members in these organizations. But ordinary researchers can also benefit from these recommendations. The guidance provided here is intended to help achieve widespread, uniform human and machine accessibility of deposited data, in support of significantly improved verification, validation, reproducibility and re-use of scholarly/scientific data.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valassi, A.; Clemencic, M.; Dykstra, D.

The Persistency Framework consists of three software packages (CORAL, COOL and POOL) addressing the data access requirements of the LHC experiments in different areas. It is the result of the collaboration between the CERN IT Department and the three experiments (ATLAS, CMS and LHCb) that use this software to access their data. POOL is a hybrid technology store for C++ objects, metadata catalogs and collections. CORAL is a relational database abstraction layer with an SQL-free API. COOL provides specific software tools and components for the handling of conditions data. This paper reports on the status and outlook of the projectmore » and reviews in detail the usage of each package in the three experiments.« less

Web-Based Consumer Health Information: Public Access, Digital Division, and Remainders

PubMed Central

Lorence, Daniel; Park, Heeyoung

2006-01-01

Public access Internet portals and decreasing costs of personal computers have created a growing consensus that unequal access to information, or a “digital divide,” has largely disappeared for US consumers. A series of technology initiatives in the late 1990s were believed to have largely eliminated the divide. For healthcare patients, access to information is an essential part of the consumer-centric framework outlined in the recently proposed national health information initiative. Data from a recent study of health information-seeking behaviors on the Internet suggest that a “digitally underserved group” persists, effectively limiting the planned national health information infrastructure to wealthier Americans. PMID:16926743

Lessons Learned from Managing a Petabyte

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becla, J

2005-01-20

The amount of data collected and stored by the average business doubles each year. Many commercial databases are already approaching hundreds of terabytes, and at this rate, will soon be managing petabytes. More data enables new functionality and capability, but the larger scale reveals new problems and issues hidden in ''smaller'' terascale environments. This paper presents some of these new problems along with implemented solutions in the framework of a petabyte dataset for a large High Energy Physics experiment. Through experience with two persistence technologies, a commercial database and a file-based approach, we expose format-independent concepts and issues prevalent atmore » this new scale of computing.« less

Clusters of poverty and disease emerge from feedbacks on an epidemiological network.

PubMed

Pluciński, Mateusz M; Ngonghala, Calistus N; Getz, Wayne M; Bonds, Matthew H

2013-03-06

The distribution of health conditions is characterized by extreme inequality. These disparities have been alternately attributed to disease ecology and the economics of poverty. Here, we provide a novel framework that integrates epidemiological and economic growth theory on an individual-based hierarchically structured network. Our model indicates that, under certain parameter regimes, feedbacks between disease ecology and economics create clusters of low income and high disease that can stably persist in populations that become otherwise predominantly rich and free of disease. Surprisingly, unlike traditional poverty trap models, these localized disease-driven poverty traps can arise despite homogeneity of parameters and evenly distributed initial economic conditions.

A design thinking framework for healthcare management and innovation.

PubMed

Roberts, Jess P; Fisher, Thomas R; Trowbridge, Matthew J; Bent, Christine

2016-03-01

The business community has learned the value of design thinking as a way to innovate in addressing people's needs--and health systems could benefit enormously from doing the same. This paper lays out how design thinking applies to healthcare challenges and how systems might utilize this proven and accessible problem-solving process. We show how design thinking can foster new approaches to complex and persistent healthcare problems through human-centered research, collective and diverse teamwork and rapid prototyping. We introduce the core elements of design thinking for a healthcare audience and show how it can supplement current healthcare management, innovation and practice. Copyright © 2015 Elsevier Inc. All rights reserved.

Nuclear Deformation at Finite Temperature

NASA Astrophysics Data System (ADS)

Alhassid, Y.; Gilbreth, C. N.; Bertsch, G. F.

2014-12-01

Deformation, a key concept in our understanding of heavy nuclei, is based on a mean-field description that breaks the rotational invariance of the nuclear many-body Hamiltonian. We present a method to analyze nuclear deformations at finite temperature in a framework that preserves rotational invariance. The auxiliary-field Monte Carlo method is used to generate a statistical ensemble and calculate the probability distribution associated with the quadrupole operator. Applying the technique to nuclei in the rare-earth region, we identify model-independent signatures of deformation and find that deformation effects persist to temperatures higher than the spherical-to-deformed shape phase-transition temperature of mean-field theory.

Recent Progress in Discrete Dislocation Dynamics and Its Applications to Micro Plasticity

NASA Astrophysics Data System (ADS)

Po, Giacomo; Mohamed, Mamdouh S.; Crosby, Tamer; Erel, Can; El-Azab, Anter; Ghoniem, Nasr

2014-10-01

We present a self-contained review of the discrete dislocation dynamics (DDD) method for the numerical investigation of plasticity in crystals, focusing on recent development and implementation progress. The review covers the theoretical foundations of DDD within the framework of incompatible elasticity, its numerical implementation via the nodal method, the extension of the method to finite domains and several implementation details. Applications of the method to current topics in micro-plasticity are presented, including the size effects in nano-indentation, the evolution of the dislocation microstructure in persistent slip bands, and the phenomenon of dislocation avalanches in micro-pillar compression.

Quantum fluctuations and the closing of the Coulomb gap in a correlated insulator.

PubMed

Roy, A S; Hoekstra, A F Th; Rosenbaum, T F; Griessen, R

2002-12-30

The "switchable mirror" yttrium hydride is one of the few strongly correlated systems with a continuous Mott-Hubbard metal-insulator transition. We systematically map out the low temperature electrical transport from deep in the insulator to the quantum critical point using persistent photoconductivity as a drive parameter. Both activated hopping over a Coulomb gap and power-law quantum fluctuations must be included to describe the data. Collapse of the data onto a universal curve within a dynamical scaling framework (with corrections) requires znu=6.0+/-0.5, where nu and z are the static and dynamical critical exponents, respectively.

Epigenetics Mechanisms in Alzheimer’s disease

PubMed Central

Mastroeni, Diego; Grover, Andrew; Delvaux, Elaine; Whiteside, Charisse; Coleman, Paul D.; Rogers, Joseph

2011-01-01

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer’s disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD. PMID:21482442

Zeolitic imidazolate framework-7: Novel ammonia atmosphere-assisted synthesis, thermal and chemical durability, phase reversibility and potential as highly efficient nanophotocatalyst

NASA Astrophysics Data System (ADS)

Ebrahimi, Arash; Mansournia, Mohammadreza

2018-07-01

This is the first representation of novel sodalite zeolitic imidazolate framework-7 (ZIF-7) which has been made in ethanolic solution at room temperature via an ammonia atmosphere. High thermal stability up to 400 °C is representative of great persistence which has been proved by XRD and TG data. Chemical durability of the as-made ZIF-7 especially at boiled DMF exhibited by XRD patterns can present it as an interesting material without structural alteration after treatment in such harsh condition. Reversible phase transformation of ZIF-7 was totally checked by immersing in ethanol and DMF indicated that the framework can maintain its structural flexibility under heat and solvent treatment. Moreover, the "gate-opening" phenomenon performed by CO2 adsorption-desorption reveals structural breathing effect of ZIF-7 framework that makes it as potential material in CO2 adsorption/separation. In the end, the sacrificial metal-doped (Mn2+, Ni2+, Cu2+, Cd2+ and Ag+) ZIF-7 precursors were applied for preparation of their corresponded metal-doped ZnO as the heterogeneous catalyst to degrade Rhodamine-B (RhB) dye in water under UV-irradiation (up to 99% within 90 min by 0.5% Ag-ZnO (S15)). The recyclability experiment after 5 runs for the optimized catalyst demonstrated that the metal-doped ZnO can be operated consecutively without remarkable decreasing in its activity. These observations exhibit the excellent and beneficial properties of metal-doped ZnO can be as heterogeneous photocatalyst for the removal of organic contaminants in water.

Fast–slow continuum and reproductive strategies structure plant life-history variation worldwide

PubMed Central

Salguero-Gómez, Roberto; Jones, Owen R.; Jongejans, Eelke; Blomberg, Simon P.; Hodgson, David J.; Mbeau-Ache, Cyril; Zuidema, Pieter A.; de Kroon, Hans; Buckley, Yvonne M.

2016-01-01

The identification of patterns in life-history strategies across the tree of life is essential to our prediction of population persistence, extinction, and diversification. Plants exhibit a wide range of patterns of longevity, growth, and reproduction, but the general determinants of this enormous variation in life history are poorly understood. We use demographic data from 418 plant species in the wild, from annual herbs to supercentennial trees, to examine how growth form, habitat, and phylogenetic relationships structure plant life histories and to develop a framework to predict population performance. We show that 55% of the variation in plant life-history strategies is adequately characterized using two independent axes: the fast–slow continuum, including fast-growing, short-lived plant species at one end and slow-growing, long-lived species at the other, and a reproductive strategy axis, with highly reproductive, iteroparous species at one extreme and poorly reproductive, semelparous plants with frequent shrinkage at the other. Our findings remain consistent across major habitats and are minimally affected by plant growth form and phylogenetic ancestry, suggesting that the relative independence of the fast–slow and reproduction strategy axes is general in the plant kingdom. Our findings have similarities with how life-history strategies are structured in mammals, birds, and reptiles. The position of plant species populations in the 2D space produced by both axes predicts their rate of recovery from disturbances and population growth rate. This life-history framework may complement trait-based frameworks on leaf and wood economics; together these frameworks may allow prediction of responses of plants to anthropogenic disturbances and changing environments. PMID:26699477

Fast-slow continuum and reproductive strategies structure plant life-history variation worldwide.

PubMed

Salguero-Gómez, Roberto; Jones, Owen R; Jongejans, Eelke; Blomberg, Simon P; Hodgson, David J; Mbeau-Ache, Cyril; Zuidema, Pieter A; de Kroon, Hans; Buckley, Yvonne M

2016-01-05

The identification of patterns in life-history strategies across the tree of life is essential to our prediction of population persistence, extinction, and diversification. Plants exhibit a wide range of patterns of longevity, growth, and reproduction, but the general determinants of this enormous variation in life history are poorly understood. We use demographic data from 418 plant species in the wild, from annual herbs to supercentennial trees, to examine how growth form, habitat, and phylogenetic relationships structure plant life histories and to develop a framework to predict population performance. We show that 55% of the variation in plant life-history strategies is adequately characterized using two independent axes: the fast-slow continuum, including fast-growing, short-lived plant species at one end and slow-growing, long-lived species at the other, and a reproductive strategy axis, with highly reproductive, iteroparous species at one extreme and poorly reproductive, semelparous plants with frequent shrinkage at the other. Our findings remain consistent across major habitats and are minimally affected by plant growth form and phylogenetic ancestry, suggesting that the relative independence of the fast-slow and reproduction strategy axes is general in the plant kingdom. Our findings have similarities with how life-history strategies are structured in mammals, birds, and reptiles. The position of plant species populations in the 2D space produced by both axes predicts their rate of recovery from disturbances and population growth rate. This life-history framework may complement trait-based frameworks on leaf and wood economics; together these frameworks may allow prediction of responses of plants to anthropogenic disturbances and changing environments.

Translational research in addiction: toward a framework for the development of novel therapeutics.

PubMed

Paterson, Neil E

2011-06-15

The development of novel substance use disorder (SUD) therapeutics is insufficient to meet the medical needs of a growing SUD patient population. The identification of translatable SUD models and tests is a crucial step in establishing a framework for SUD therapeutic development programs. The present review begins by identifying the clinical features of SUDs and highlights the narrow regulatory end-point required for approval of a novel SUD therapeutic. A conceptual overview of dependence is provided, followed by identification of potential intervention targets in the addiction cycle. The main components of the addiction cycle provide the framework for a discussion of preclinical models and their clinical analogs, all of which are focused on isolated behavioral end-points thought to be relevant to the persistence of compulsive drug use. Thus, the greatest obstacle to successful development is the gap between the multiplicity of preclinical and early clinical end-points and the regulatory end-point of sustained abstinence. This review proposes two pathways to bridging this gap: further development and validation of the preclinical extended access self-administration model; inclusion of secondary end-points comprising all of the measures highlighted in the present discussion in Phase 3 trials. Further, completion of the postdictive validation of analogous preclinical and clinical assays is of high priority. Ultimately, demonstration of the relevance and validity of a variety of end-points to the ultimate goal of abstinence will allow researchers to identify truly relevant therapeutic mechanisms and intervention targets, and establish a framework for SUD therapeutic development that allows optimal decision-making and resource allocation. 2011 Elsevier Inc. All rights reserved.

x509-free access to WLCG resources

NASA Astrophysics Data System (ADS)

Short, H.; Manzi, A.; De Notaris, V.; Keeble, O.; Kiryanov, A.; Mikkonen, H.; Tedesco, P.; Wartel, R.

2017-10-01

Access to WLCG resources is authenticated using an x509 and PKI infrastructure. Even though HEP users have always been exposed to certificates directly, the development of modern Web Applications by the LHC experiments calls for simplified authentication processes keeping the underlying software unmodified. In this work we will show a solution with the goal of providing access to WLCG resources using the user’s home organisations credentials, without the need for user-acquired x509 certificates. In particular, we focus on identity providers within eduGAIN, which interconnects research and education organisations worldwide, and enables the trustworthy exchange of identity-related information. eduGAIN has been integrated at CERN in the SSO infrastructure so that users can authenticate without the need of a CERN account. This solution achieves x509-free access to Grid resources with the help of two services: STS and an online CA. The STS (Security Token Service) allows credential translation from the SAML2 format used by Identity Federations to the VOMS-enabled x509 used by most of the Grid. The IOTA CA (Identifier-Only Trust Assurance Certification Authority) is responsible for the automatic issuing of short-lived x509 certificates. The IOTA CA deployed at CERN has been accepted by EUGridPMA as the CERN LCG IOTA CA, included in the IGTF trust anchor distribution and installed by the sites in WLCG. We will also describe the first pilot projects which are integrating the solution.

Persistent Identifiers for Dutch cultural heritage institutions

NASA Astrophysics Data System (ADS)

Ras, Marcel; Kruithof, Gijsbert

2016-04-01

Over the past years, more and more collections belonging to archives, libraries, media, museums, and knowledge institutes are being digitised and made available online. These are exciting times for ALM institutions. They are realising that, in the information society, their collections are goldmines. Unfortunately most heritage institutions in the Netherlands do not yet meet the basic preconditions for long-term availability of their collections. The digital objects often have no long lasting fixed reference yet. URL's and web addresses change. Some digital objects that were referenced in Europeana and other portals can no longer be found. References in scientific articles have a very short life span, which is damaging for scholarly research. In 2015, the Dutch Digital Heritage Network (NDE) has started a two-year work program to co-ordinate existing initiatives in order to improve the (long-term) accessibility of the Dutch digital heritage for a wide range of users, anytime, anyplace. The Digital Heritage Network is a partnership established on the initiative of the Ministry of Education, Culture and Science. The members of the NDE are large, national institutions that strive to professionally preserve and manage digital data, e.g. the National Library, The Netherlands Institute for Sound and Vision, the Netherlands Cultural Heritage Agency, the Royal Netherlands Academy of Arts and Sciences, the National Archive of the Netherlands and the DEN Foundation, and a growing number of associations and individuals both within and outside the heritage sector. By means of three work programmes the goals of the Network should be accomplished and improve the visibility, the usability and the sustainability of digital heritage. Each programme contains of a set of projects. Within the sustainability program a project on creating a model for persistent identifiers is taking place. The main goals of the project are (1) raise awareness among cultural heritage institutions on the subject of persistent identifiers, (2) develop a business model for a persistent identifier service especially for smaller CH organisations, and (3) set up some show cases. Some of the products delivered by the project in 2016 will be: (1) a business model for a persistent identifier service based on an affordable co-financing model (2) a technical implementation of a persistent identifier service based on one of the existing PI models (3) a general agreement with suppliers of collection management systems and record management systems used by cultural heritage institutions in The Netherlands (4) a decision tree for cultural heritage organisations which can guide them through the process of selecting a particular type of Persistent Identifier (Handle, DOI, ARK or NBN:URN) (5) a technical implementation help function In the presentation we will explain the collaborative work carried out in The Netherlands within the framework of the NDE Network, focusing on the Persistent Identifiers project. We will present our preliminary results on communication strategy, business model and decision tree. And we will speak about the discussions we have with the commercial vendors of record management systems in order to built-in facilities for persistent identifiers in the systems used by the Dutch cultural heritage organisations.

Pika (Ochotona princeps) losses from two isolated regions reflect temperature and water balance, but reflect habitat area in a mainland region

USGS Publications Warehouse

Beever, Erik A.; Perrine, John D.; Rickman, Tom; Flores, Mary; Clark, John P.; Waters, Cassie; Weber, Shana S.; Yardley, Braden; Thoma, David P.; Chesley-Preston, Tara; Goehring, Kenneth E.; Magnuson, Michael; Nordensten, Nancy; Nelson, Melissa; Collins, Gail H.

2016-01-01

Although biotic responses to contemporary climate change are spatially pervasive and often reflect synergies between climate and other ecological disturbances, the relative importance of climatic factors versus habitat extent for species persistence remains poorly understood. To address this shortcoming, we performed surveys for American pikas (Ochotona princeps) at > 910 locations in 3 geographic regions of western North America during 2014 and 2015, complementing earlier modern (1994–2013) and historical (1898–1990) surveys. We sought to compare extirpation rates and the relative importance of climatic factors versus habitat area for pikas in a mainland-versus-islands framework. In each region, we found widespread evidence of distributional loss—local extirpations, upslope retractions, and encounter of only old sign. Locally comprehensive surveys suggest extirpation of O. princeps from 5 of 9 new sites from the hydrographic Great Basin and from 11 of 29 sites in northeastern California. Although American pikas were recorded as recently as 2011 in Zion National Park and in 2012 from Cedar Breaks National Monument in Utah, O. princeps now appears extirpated from all reported localities in both park units. Multiple logistic regressions for each region suggested that both temperature-related and water-balance-related variables estimated from DAYMET strongly explained pika persistence at sites in the Great Basin and in Utah but not in the Sierra-Cascade “mainland” portion of northeastern California. Conversely, talus-habitat area did not predict American pika persistence in the Great Basin or Utah but strongly predicted persistence in the Sierra-Cascade mainland. These results not only add new areas to our understanding of long-term trend of the American pika’s distribution, but also can inform decisions regarding allocation of conservation effort and management actions. Burgeoning research on species such as O. princeps has collectively demonstrated the heterogeneity and nuance with which climate can act on the distribution of mountain-dwelling mammals.

Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology

PubMed Central

Shackman, Alexander J.; Fox, Andrew S.; Oler, Jonathan A.; Shelton, Steven E.; Oakes, Terrence R.; Davidson, Richard J.; Kalin, Ned H.

2016-01-01

Children with an anxious temperament (AT) are prone to heightened shyness and behavioral inhibition (BI). When chronic and extreme, this anxious, inhibited phenotype is an important early-life risk factor for the development of anxiety disorders, depression, and co-morbid substance abuse. Individuals with extreme AT often show persistent distress in the absence of immediate threat and this contextually inappropriate anxiety predicts future symptom development. Despite its clear clinical relevance, the neural circuitry governing the maladaptive persistence of anxiety remains unknown. Here, we used a well-established nonhuman primate model of childhood temperament and high-resolution 18fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to understand the neural systems governing persistent anxiety and clarify their relevance to early-life phenotypic risk. We focused on BI, a core component of anxious temperament, because it affords the moment-by-moment temporal resolution needed to assess contextually appropriate and inappropriate anxiety. From a pool of 109 peri-adolescent rhesus monkeys, we formed groups characterized by high or low levels of BI, as indexed by freezing in response to an unfamiliar human intruder’s profile. The High-BI group showed consistently elevated signs of anxiety and wariness across more than 2 years of assessments. At the time of brain imaging, 1.5 years after initial phenotyping, the High-BI group showed persistently elevated freezing during a 30-min ‘recovery’ period following an encounter with the intruder — more than an order of magnitude greater than the Low-BI group — and this was associated with increased metabolism in the bed nucleus of the stria terminalis, a key component of the central extended amygdala. These observations provide a neurobiological framework for understanding the early phenotypic risk to develop anxiety-related psychopathology, for accelerating the development of improved interventions, and for understanding the origins of childhood temperament. PMID:27573879

Assessing hypotheses about nesting site occupancy dynamics

USGS Publications Warehouse

Bled, Florent; Royle, J. Andrew; Cam, Emmanuelle

2011-01-01

Hypotheses about habitat selection developed in the evolutionary ecology framework assume that individuals, under some conditions, select breeding habitat based on expected fitness in different habitat. The relationship between habitat quality and fitness may be reflected by breeding success of individuals, which may in turn be used to assess habitat quality. Habitat quality may also be assessed via local density: if high-quality sites are preferentially used, high density may reflect high-quality habitat. Here we assessed whether site occupancy dynamics vary with site surrogates for habitat quality. We modeled nest site use probability in a seabird subcolony (the Black-legged Kittiwake, Rissa tridactyla) over a 20-year period. We estimated site persistence (an occupied site remains occupied from time t to t + 1) and colonization through two subprocesses: first colonization (site creation at the timescale of the study) and recolonization (a site is colonized again after being deserted). Our model explicitly incorporated site-specific and neighboring breeding success and conspecific density in the neighborhood. Our results provided evidence that reproductively "successful'' sites have a higher persistence probability than "unsuccessful'' ones. Analyses of site fidelity in marked birds and of survival probability showed that high site persistence predominantly reflects site fidelity, not immediate colonization by new owners after emigration or death of previous owners. There is a negative quadratic relationship between local density and persistence probability. First colonization probability decreases with density, whereas recolonization probability is constant. This highlights the importance of distinguishing initial colonization and recolonization to understand site occupancy. All dynamics varied positively with neighboring breeding success. We found evidence of a positive interaction between site-specific and neighboring breeding success. We addressed local population dynamics using a site occupancy approach integrating hypotheses developed in behavioral ecology to account for individual decisions. This allows development of models of population and metapopulation dynamics that explicitly incorporate ecological and evolutionary processes.

Persistent Homology fingerprinting of microstructural controls on larger-scale fluid flow in porous media

NASA Astrophysics Data System (ADS)

Moon, C.; Mitchell, S. A.; Callor, N.; Dewers, T. A.; Heath, J. E.; Yoon, H.; Conner, G. R.

2017-12-01

Traditional subsurface continuum multiphysics models include useful yet limiting geometrical assumptions: penny- or disc-shaped cracks, spherical or elliptical pores, bundles of capillary tubes, cubic law fracture permeability, etc. Each physics (flow, transport, mechanics) uses constitutive models with an increasing number of fit parameters that pertain to the microporous structure of the rock, but bear no inter-physics relationships or self-consistency. Recent advances in digital rock physics and pore-scale modeling link complex physics to detailed pore-level geometries, but measures for upscaling are somewhat unsatisfactory and come at a high computational cost. Continuum mechanics rely on a separation between small scale pore fluctuations and larger scale heterogeneity (and perhaps anisotropy), but this can break down (particularly for shales). Algebraic topology offers powerful mathematical tools for describing a local-to-global structure of shapes. Persistent homology, in particular, analyzes the dynamics of topological features and summarizes into numeric values. It offers a roadmap to both "fingerprint" topologies of pore structure and multiscale connectedness as well as links pore structure to physical behavior, thus potentially providing a means to relate the dependence of constitutive behaviors of pore structures in a self-consistent way. We present a persistence homology (PH) analysis framework of 3D image sets including a focused ion beam-scanning electron microscopy data set of the Selma Chalk. We extract structural characteristics of sampling volumes via persistence homology and fit a statistical model using the summarized values to estimate porosity, permeability, and connectivity—Lattice Boltzmann methods for single phase flow modeling are used to obtain the relationships. These PH methods allow for prediction of geophysical properties based on the geometry and connectivity in a computationally efficient way. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia LLC, a wholly owned subsidiary of Honeywell International Inc. for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.

Can the complementary relationship between actual and potential evaporation be used to quantify heatwaves?

NASA Astrophysics Data System (ADS)

Aminzadeh, Milad; Or, Dani

2017-04-01

Extreme climate events such as heatwaves with prolonged periods of high air temperatures have large environmental, social, and economic impacts ranging from crop failure to health and desiccation damages. Periods of low precipitation with high temperatures decrease soil moisture storage and thus affect surface energy partitioning. The heuristic concepts in the basis of the Complementary Relationship (CR) suggest that a fraction of radiative energy not used for evaporation contributes to increased sensible heat flux thus heats near-surface atmosphere. We have recently generalized the CR framework for spatially heterogeneous landscapes thereby enable prediction of actual evapotranspiration (ET) from routine atmospheric measurements. Capitalizing on the coupling between moisture availability, actual ET and sensible heat flux we propose using the CR to predict conditions conducive to rapid increase in regional sensible heat flux associated with the onset of extreme heatwaves. The proposed framework is evaluated using satellite surface temperature and FLUXNET data with newly derived metrics for the onset of heatwaves. The concepts could be extended to obtain new insights into the dynamics of more persistent climate extremes such as regional droughts.

Time to Go Beyond Triple-Gauge-Boson-Coupling Interpretation of W Pair Production.

PubMed

Zhang, Zhengkang

2017-01-06

W boson pair production processes at e^{+}e^{-} and pp colliders have been conventionally interpreted as measurements of WWZ and WWγ triple gauge couplings (TGCs). Such an interpretation is based on the assumption that new physics effects other than anomalous TGCs are negligible. While this "TGC dominance assumption" was well motivated and useful at LEP2 thanks to precision electroweak constraints, it is already challenged by recent LHC data. In fact, contributions from anomalous Z boson couplings that are allowed by electroweak precision data but neglected in LHC analyses, which are enhanced at high energy, can even dominate over those from the anomalous TGCs considered. This limits the generality of the anomalous TGC constraints derived in current analyses and necessitates extension of the analysis framework and a change of physics interpretation. The issue will persist as we continue to explore the high-energy frontier. We clarify and analyze the situation in the effective field theory framework, which provides a useful organizing principle for understanding standard model deviations in the high-energy regime.

Reaching for Health Equity and Social Justice in Baltimore: The Evolution of an Academic-Community Partnership and Conceptual Framework to Address Hypertension Disparities

PubMed Central

Cooper, Lisa A.; Purnell, Tanjala S.; Ibe, Chidinma A.; Halbert, Jennifer P.; Bone, Lee R.; Carson, Kathryn A.; Hickman, Debra; Simmons, Michelle; Vachon, Ann; Robb, Inez; Martin-Daniels, Michelle; Dietz, Katherine B.; Golden, Sherita Hill; Crews, Deidra C.; Hill-Briggs, Felicia; Marsteller, Jill A.; Boulware, L. Ebony; Miller, Edgar R. III; Levine, David M.

2016-01-01

Cardiovascular health disparities persist despite decades of recognition and the availability of evidence-based clinical and public health interventions. Racial and ethnic minorities and adults in urban and low-income communities are high-risk groups for uncontrolled hypertension (HTN), a major contributor to cardiovascular health disparities, in part due to inequitable social structures and economic systems that negatively impact daily environments and risk behaviors. This commentary presents the Johns Hopkins Center to Eliminate Cardiovascular Health Disparities as a case study for highlighting the evolution of an academic-community partnership to overcome HTN disparities. Key elements of the iterative development process of a Community Advisory Board (CAB) are summarized, and major CAB activities and engagement with the Baltimore community are highlighted. Using a conceptual framework adapted from O’Mara-Eves and colleagues, the authors discuss how different population groups and needs, motivations, types and intensity of community participation, contextual factors, and actions have shaped the Center’s approach to stakeholder engagement in research and community outreach efforts to achieve health equity. PMID:27440977

A Sociocognitive Perspective of Women's Participation in Physics: Improving Accessibility throughout the Pipeline

NASA Astrophysics Data System (ADS)

Kelly, Angela

2017-01-01

Sociopsychological theories and empirical research provide a framework for exploring causal pathways and targeted interventions to increase the representation of women in post-secondary physics. Women earned only 19.7 percent of physics undergraduate degrees in 2012 (APS, 2015). This disparity has been attributed to a variety of factors, including chilly classroom climates, gender-based stereotypes, persistent self-doubt, and a lack of role models in physics departments. The theoretical framework for this research synthesis is based upon several psychological theories of sociocognitive behavior and is derived from three general constructs: 1) self-efficacy and self-concept; 2) expectancy value and planned behavior; and 3) motivation and self-determination. Recent studies have suggested that the gender discrepancy in physics participation may be alleviated by applying interventions derived from social cognitive research. These interventions include social and familial support, welcoming and collaborative classroom environments, critical feedback, and identification with a malleable view of intelligence. This research provides empirically supported mechanisms for university stakeholders to implement reforms that will increase women's participation in physics.

General ecological models for human subsistence, health and poverty.

PubMed

Ngonghala, Calistus N; De Leo, Giulio A; Pascual, Mercedes M; Keenan, Donald C; Dobson, Andrew P; Bonds, Matthew H

2017-08-01

The world's rural poor rely heavily on their immediate natural environment for subsistence and suffer high rates of morbidity and mortality from infectious diseases. We present a general framework for modelling subsistence and health of the rural poor by coupling simple dynamic models of population ecology with those for economic growth. The models show that feedbacks between the biological and economic systems can lead to a state of persistent poverty. Analyses of a wide range of specific systems under alternative assumptions show the existence of three possible regimes corresponding to a globally stable development equilibrium, a globally stable poverty equilibrium and bistability. Bistability consistently emerges as a property of generalized disease-economic systems for about a fifth of the feasible parameter space. The overall proportion of parameters leading to poverty is larger than that resulting in healthy/wealthy development. All the systems are found to be most sensitive to human disease parameters. The framework highlights feedbacks, processes and parameters that are important to measure in studies of rural poverty to identify effective pathways towards sustainable development.

Eliminating tobacco-related disparities among Pacific Islanders through leadership and capacity building: promising practices and lessons learned.

PubMed

David, Annette M; Lew, Rod; Lyman, Annabel K; Otto, Caleb; Robles, Rebecca; Cruz, George J

2013-09-01

Tobacco remains a major risk factor for premature death and ill health among Pacific Islanders, and tobacco-related disparities persist. Eliminating these disparities requires a comprehensive approach to transform community norms about tobacco use through policy change, as contained in the World Health Organization international Framework Convention on Tobacco Control. Three of the six U.S.-affiliated Pacific Islands-the Federated States of Micronesia, Palau, and the Marshall Islands-are Parties to the Framework; the remaining three territories-American Samoa, the Commonwealth of the Northern Mariana Islands, and Guam-are excluded from the treaty by virtue of U.S. nonratification. Capacity building and leadership development are essential in achieving policy change and health equity within Pacific Islander communities. We describe promising practices from American Samoa, the Commonwealth of the Northern Mariana Islands, the Federated States of Micronesia, Guam, and Palau and highlight some of the key lessons learned in supporting and sustaining the reduction in tobacco use among Pacific Islanders as the first step toward eliminating tobacco-related disparities in these populations.

A Conceptual Framework of Mapping Access to Health Care across EU Countries: The Patient Access Initiative.

PubMed

Souliotis, Kyriakos; Hasardzhiev, Stanimir; Agapidaki, Eirini

Research evidence suggests that access to health care is the key influential factor for improved population health outcomes and health care system sustainability. Although the importance of addressing barriers in access to health care across European countries is well documented, little has been done to improve the situation. This is due to different definitions, approaches and policies, and partly due to persisting disparities in access within and between European countries. To bridge this gap, the Patient Access Partnership (PACT) developed (a) the '5As' definition of access, which details the five critical elements (adequacy, accessibility, affordability, appropriateness, and availability) of access to health care, (b) a multi-stakeholders' approach for mapping access, and (c) a 13-item questionnaire based on the 5As definition in an effort to address these obstacles and to identify best practices. These tools are expected to contribute effectively to addressing access barriers in practice, by suggesting a common framework and facilitating the exchange of knowledge and expertise, in order to improve access to health care between and within European countries. © 2016 S. Karger AG, Basel.

How do adults and teens with self-declared Autism Spectrum Disorder experience eye contact? A qualitative analysis of first-hand accounts

PubMed Central

Roberts, Nicole; Lin, Cathy; Birmingham, Elina

2017-01-01

A tendency to avoid eye contact is an early indicator of Autism Spectrum Disorder (ASD), and difficulties with eye contact often persist throughout the lifespan. Eye contact difficulties may underlie social cognitive deficits in ASD, and can create significant social and occupational barriers. Thus, this topic has received substantial research and clinical attention. In this study, we used qualitative methods to analyze self-reported experiences with eye contact as described by teens and adults with self-declared ASD. Results suggest people with a self- declared ASD diagnosis experience adverse emotional and physiological reactions, feelings of being invaded, and sensory overload while making eye contact, in addition to difficulties understanding social nuances, and difficulties receiving and sending nonverbal information. Some data support existing mindblindness frameworks, and hyperarousal or hypoarousal theories of eye contact, but we also present novel findings unaccounted for by existing frameworks. Additionally, we highlight innovative strategies people with self-declared ASD have devised to overcome or cope with their eye contact difficulties. PMID:29182643

Changing the Metacognitive Orientation of a Classroom Environment to Stimulate Metacognitive Reflection Regarding the Nature of Physics Learning

NASA Astrophysics Data System (ADS)

Thomas, Gregory P.

2013-05-01

Problems persist with physics learning in relation to students' understanding and use of representations for making sense of physics concepts. Further, students' views of physics learning and their physics learning processes have been predominantly found to reflect a 'surface' approach to learning that focuses on mathematical aspects of physics learning that are often passed on via textbooks and lecture-style teaching. This paper reports on a teacher's effort to stimulate students' metacognitive reflection regarding their views of physics learning and their physics learning processes via a pedagogical change that incorporated the use of a representational framework and metaphors. As a consequence of the teacher's pedagogical change, students metacognitively reflected on their views of physics and their learning processes and some reported changes in their views of what it meant to understand physics and how they might learn and understand physics concepts. The findings provide a basis for further explicit teaching of representational frameworks to students in physics education as a potential means of addressing issues with their physics learning.

Translating the Social-Ecological Perspective Into Multilevel Interventions for Family Planning: How Far Are We?

PubMed

Schölmerich, Vera L N; Kawachi, Ichiro

2016-06-01

Scholars and practitioners frequently make recommendations to develop family planning interventions that are "multilevel." Such interventions take explicit account of the role of environments by incorporating multilevel or social-ecological frameworks into their design and implementation. However, research on how interventions have translated these concepts into practice in the field of family planning-and generally in public health-remains scarce. This article seeks to review the current definitions of multilevel interventions and their operationalization in the field of family planning. First, we highlight the divergent definitions of multilevel interventions and show the persistent ambiguity around this term. We argue that interventions involving activities at several levels but lacking targets (i.e., objectives) to create change on more than one level have not incorporated a social-ecological framework and should therefore not be considered as "multilevel." In a second step, we assess the extent to which family planning interventions have successfully incorporated a social-ecological framework. To this end, the 63 studies featured in Mwaikambo et al.'s systematic review on family planning interventions were reexamined. This assessment indicates that the multilevel or social-ecological perspective has seldom been translated into interventions. Specifically, the majority of interventions involved some form of activity at the community and/or organizational level, yet targeted and measured intrapersonal change as opposed to explicitly targeting/measuring environmental modification. © 2016 Society for Public Health Education.

Principles of Public Reason in the UNFCCC: Rethinking the Equity Framework.

PubMed

Boran, Idil

2017-10-01

Since 2011, the focus of international negotiations under the UNFCCC has been on producing a new climate agreement to be adopted in 2015. This phase of negotiations is known as the Durban Platform for Enhanced Action. The goal has been to update the global effort on climate for long-term cooperation. In this period, various changes have been contemplated on the design of the architecture of the global climate effort. Whereas previously, the negotiation process consisted of setting mandated targets exclusively for developed countries, the current setting requests of each country to pledge its contribution to the climate effort in the form of Intended Nationally Determined Contributions (INDCs). The shift away from establishing negotiated targets for rich countries alone towards a universal system of participation through intended contributions raised persistent questions on how exactly the new agreement can ensure equitable terms. How to conceptualize equity within the 2015 climate agreement, and beyond, is the focus of this paper. The paper advances a framework on equity, which moves away from substantive moral conceptions of burden allocation toward refining principles of public reason specially designed for the negotiation process under the UNFCCC. The paper outlines the framework's main features and discusses how it can serve a facilitating role for multilateral discussion on equity on a long-term basis capable of adapting to changing circumstances.

Mission Data System Java Edition Version 7

NASA Technical Reports Server (NTRS)

Reinholtz, William K.; Wagner, David A.

2013-01-01

The Mission Data System framework defines closed-loop control system abstractions from State Analysis including interfaces for state variables, goals, estimators, and controllers that can be adapted to implement a goal-oriented control system. The framework further provides an execution environment that includes a goal scheduler, execution engine, and fault monitor that support the expression of goal network activity plans. Using these frameworks, adapters can build a goal-oriented control system where activity coordination is verified before execution begins (plan time), and continually during execution. Plan failures including violations of safety constraints expressed in the plan can be handled through automatic re-planning. This version optimizes a number of key interfaces and features to minimize dependencies, performance overhead, and improve reliability. Fault diagnosis and real-time projection capabilities are incorporated. This version enhances earlier versions primarily through optimizations and quality improvements that raise the technology readiness level. Goals explicitly constrain system states over explicit time intervals to eliminate ambiguity about intent, as compared to command-oriented control that only implies persistent intent until another command is sent. A goal network scheduling and verification process ensures that all goals in the plan are achievable before starting execution. Goal failures at runtime can be detected (including predicted failures) and handled by adapted response logic. Responses can include plan repairs (try an alternate tactic to achieve the same goal), goal shedding, ignoring the fault, cancelling the plan, or safing the system.

Clinical trials recruitment planning: A proposed framework from the Clinical Trials Transformation Initiative.

PubMed

Huang, Grant D; Bull, Jonca; Johnston McKee, Kelly; Mahon, Elizabeth; Harper, Beth; Roberts, Jamie N

2018-03-01

Patient recruitment is widely recognized as a key determinant of success for clinical trials. Yet a substantial number of trials fail to reach recruitment goals-a situation that has important scientific, financial, ethical, and policy implications. Further, there are important effects on stakeholders who directly contribute to the trial including investigators, sponsors, and study participants. Despite efforts over multiple decades to identify and address barriers, recruitment challenges persist. To advance a more comprehensive approach to trial recruitment, the Clinical Trials Transformation Initiative (CTTI) convened a project team to examine the challenges and to issue actionable, evidence-based recommendations for improving recruitment planning that extend beyond common study-specific strategies. We describe our multi-stakeholder effort to develop a framework that delineates three areas essential to strategic recruitment planning efforts: (1) trial design and protocol development, (2) trial feasibility and site selection, and (3) communication. Our recommendations propose an upstream approach to recruitment planning that has the potential to produce greater impact and reduce downstream barriers. Additionally, we offer tools to help facilitate adoption of the recommendations. We hope that our framework and recommendations will serve as a guide for initial efforts in clinical trial recruitment planning irrespective of disease or intervention focus, provide a common basis for discussions in this area and generate targets for further analysis and continual improvement. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Anthropogenic impacts on deep submarine canyons of the western Mediterranean Sea

NASA Astrophysics Data System (ADS)

Sanchez-Vidal, A.; Tubau, X.; Llorca, M.; Woodall, L.; Canals, M.; Farré, M.; Barceló, D.; Thompson, R.

2016-02-01

Submarine canyons are seafloor geomorphic features connecting the shallow coastal ocean to the deep continental margin and basin. Often considered biodiversity hotspots, submarine canyons have been identified as preferential pathways for water, sediment, pollutant and litter transfers from the coastal to the deep ocean. Here we provide insights on the presence of some of the most insidious man-made debris and substances in submarine canyons of the western Mediterranean Sea, which are relevant to achieve a "Good Environmental Status" by 2020 as outlined in the European Union's ambitious Marine Strategy Framework Directive. Ranked by size on a decreasing basis, we review the origin, distribution and transport mechanisms of i) marine litter, including plastic, lost fishing gear and metallic objects; ii) microplastics in the form of fibers of rayon, polyester, polyamide and acetates; and iii) persistent organic pollutants including the toxic and persistent perfluoroalkyl substances. This integrated analysis allows us to understand the pivotal role of atmospheric driven oceanographic processes occurring in Mediterranean deep canyons (dense shelf water cascading, coastal storms) in spreading any type of man-made compound to the deep sea, where they sink and accumulate before getting buried.

Do numerical rating scales and the Roland-Morris Disability Questionnaire capture changes that are meaningful to patients with persistent back pain?

PubMed

Hush, Julia M; Refshauge, Kathryn M; Sullivan, Gerard; De Souza, Lorraine; McAuley, James H

2010-07-01

To investigate patients' views about two common outcome measures used for back pain: Numerical Rating Scales for pain and the Roland-Morris Disability Questionnaire. Thirty-six working adults who had previously sought primary care for back pain and who could speak and read English. Eight focus groups were conducted to explore participants' views about the 11-point Numerical Rating Scales and the 24-item Roland-Morris Disability Questionnaire. Each group was led by a facilitator and an interview topic guide was used. Audio recordings of focus groups were transcribed verbatim. Framework analysis was used to chart participants' views and an interpretive analysis performed to explain the findings. Participants reported that neither the Roland-Morris nor the Numerical Rating Scales captured the complex personal experience of pain or relevant changes in their condition. The time-frame of assessment was identified as particularly problematic and the Roland-Morris did not capture relevant functional domains. This study provides empirical data that working adults with persistent back pain consider these clinical outcome measures largely inadequate. These measures currently used for back pain may contribute to misleading conclusions about treatment efficacy and patient recovery.

Pursuit of communal values in an agentic manner: a way to happiness?

PubMed

Abele, Andrea E

2014-01-01

The present research studies the association between traits, values, and life satisfaction. While values should influence the direction of an individual's goals and behavior, his/her traits impact effort-expenditure, efficiency, and persistence in goal-pursuit. We apply the framework of the "Big Two" of agency and communion (Bakan, 1966) for distinguishing the content of values and traits. While agentic content refers to qualities relevant for goal-attainment, such as assertiveness, competence or persistence, communal content refers to qualities relevant for the establishment and maintenance of social relationships, such as being friendly, helpful, or fair. We predict that high scores on communal values and high scores on agentic traits are associated with life satisfaction. We test these predictions in two studies conducted in different countries (Germany and Russia) with different cultural background. The findings support our reasoning: across both countries we find positive associations of communal values and agentic traits with life satisfaction; and individuals high in communal values and high in agentic traits are most satisfied with their lives. In Russia, the association of communal values with life satisfaction is moderated by agentic traits; in Germany, however, there is a main effect of communal values.

Unifying practice schedules in the timescales of motor learning and performance.

PubMed

Verhoeven, F Martijn; Newell, Karl M

2018-06-01

In this article, we elaborate from a multiple time scales model of motor learning to examine the independent and integrated effects of massed and distributed practice schedules within- and between-sessions on the persistent (learning) and transient (warm-up, fatigue) processes of performance change. The timescales framework reveals the influence of practice distribution on four learning-related processes: the persistent processes of learning and forgetting, and the transient processes of warm-up decrement and fatigue. The superposition of the different processes of practice leads to a unified set of effects for massed and distributed practice within- and between-sessions in learning motor tasks. This analysis of the interaction between the duration of the interval of practice trials or sessions and parameters of the introduced time scale model captures the unified influence of the between trial and session scheduling of practice on learning and performance. It provides a starting point for new theoretically based hypotheses, and the scheduling of practice that minimizes the negative effects of warm-up decrement, fatigue and forgetting while exploiting the positive effects of learning and retention. Copyright © 2018 Elsevier B.V. All rights reserved.

Addressing mental health disparities through clinical competence not just cultural competence: the need for assessment of sociocultural issues in the delivery of evidence-based psychosocial rehabilitation services.

PubMed

Yamada, Ann-Marie; Brekke, John S

2008-12-01

Recognition of ethnic/racial disparities in mental health services has not directly resulted in the development of culturally responsive psychosocial interventions. There remains a fundamental need for assessment of sociocultural issues that have been linked with the expectations, needs, and goals of culturally diverse consumers with severe and persistent mental illness. The authors posit that embedding the assessment of sociocultural issues into psychosocial rehabilitation practice is one step in designing culturally relevant empirically supported practices. It becomes a foundation on which practitioners can examine the relevance of their interventions to the diversity encountered in everyday practice. This paper provides an overview of the need for culturally and clinically relevant assessment practices and asserts that by improving the assessment of sociocultural issues the clinical competence of service providers is enhanced. The authors offer a conceptual framework for linking clinical assessment of sociocultural issues to consumer outcomes and introduce an assessment tool adapted to facilitate the process in psychosocial rehabilitation settings. Emphasizing competent clinical assessment skills will ultimately offer a strategy to address disparities in treatment outcomes for understudied populations of culturally diverse consumers with severe and persistent mental illness.

A conceptual model for the growth, persistence, and blooming behavior of the benthic mat-forming diatom Didymosphenia geminata (Invited)

NASA Astrophysics Data System (ADS)

Cullis, J. D.; Gillis, C.; Bothwell, M.; Kilroy, C.; Packman, A. I.; Hassan, M. A.

2010-12-01

The nuisance diatom Didymosphenia geminata (didymo) presents an ecological paradox. How can this benthic algae produce such large amounts of biomass in cold, fast flowing, low nutrient streams? The aim of this paper is to present a conceptual model for the growth, persistence, and blooming behavior of this benthic mat-forming diatom that may help to explain this paradox. The conceptual model highlights the importance of distinguishing between mat thickness and cell growth. It presents evidence gathered from a range of existing studies around the world to support the proposed relationship between growth and light, nutrients and temperature as well as the importance of flood events and bed disturbance in mat removal. It is anticipated that this conceptual model will not only help in identifying the key controlling variables and set a framework for future studies but also support the future management of this nuisance algae. Summary of the conceptual model for didymo growth showing the proposed relationships for the growth of cells and mats with nutrients, radiation and water temperature and the dependence of removal on bed shear stress and the potential for physical bed disturbance.

White long-lasting phosphorescence generation in a CaAl2Si2O8 : Eu2+, Mn2+, Dy3+ system through persistent energy transfer

NASA Astrophysics Data System (ADS)

Zhang, Jinsu; Chen, Baojiu; Sun, Jiashi; Li, Xiangping; Cheng, Lihong; Zhong, Haiyang

2012-08-01

Based on the persistent energy transfer principle, Mn2+ was introduced into a CaAl2Si2O8 : Eu2+/Dy3+ phosphor to achieve white long-lasting emissions. Eu2+, Mn2+ and Dy3+ tri-doped CaAl2Si2O8 phosphors with various Mn2+ concentrations were prepared via a solid-state reaction, and the crystal structure of the phosphors was identified by the x-ray diffraction technique. The luminescent properties of the Eu2+, Mn2+ and Dy3+ tri-doped CaAl2Si2O8 phosphors were studied. The energy transfer behaviour from Eu2+ to Mn2+ was analysed within the framework of Dexter theory. The physical mechanism of energy transfer was assigned to the electric dipole-quadrupole interaction. It was also demonstrated that the colour coordinates of the phosphors can be tuned from the blue region to the white region in the colour space. Furthermore, the afterglow decay and thermoluminescence curves were measured, indicating excellent phosphorescence properties of the current phosphors.

Neural correlates of successful semantic processing during propofol sedation.

PubMed

Adapa, Ram M; Davis, Matthew H; Stamatakis, Emmanuel A; Absalom, Anthony R; Menon, David K

2014-07-01

Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and during recovery, while making perceptual or semantic decisions about nonspeech sounds or spoken words respectively. Sedation caused increased error rates and response times, and differentially affected responses to words in the left inferior frontal gyrus (LIFG) and the left inferior temporal gyrus (LITG). Activity in LIFG regions putatively associated with semantic processing, was significantly reduced by sedation despite sedated volunteers continuing to make accurate semantic decisions. Instead, LITG activity was preserved for words greater than nonspeech sounds and may therefore be associated with persistent semantic processing during the deepest levels of sedation. These results suggest functionally distinct contributions of frontal and temporal regions to semantic decision making. These results have implications for functional imaging studies of language, for understanding mechanisms of impaired speech comprehension in postoperative patients with residual levels of anesthetic, and may contribute to the development of frameworks against which EEG based monitors could be calibrated to detect awareness under anesthesia. Copyright © 2013 Wiley Periodicals, Inc.

Are you a ``physics person''? Understanding students' experiences, identities, and beliefs

NASA Astrophysics Data System (ADS)

Potvin, Geoff

2015-03-01

For several years, there has been much attention paid to the dearth of women in physics. Discussion has centered on various explanatory frameworks as to why women do not pursue physics in college as a career and on their persistence in such pursuits. In this talk, I will summarize efforts by our group to investigate recruitment and persistence issues for women in high school and undergraduate physics. Viewed through the lens of identity, we have repeatedly seen the importance of high school students' beliefs about the recognition they receive as a ``physics person'' to their identity development (especially so for women) and, ultimately, their physics-related career choices. Separately, we have studied the ways in which students evaluate their male and female physics teachers, which is an avenue to unravel students' beliefs and (possible) gender biases towards competency in physics. We have found statistically significant and replicable bias (in repeated independent measurements) against female physics teachers, exhibited by both male and female students. Lastly, I will report on a series of interventions that we have implemented in introductory college physics classrooms as attempts to positively affect women's attitudes towards physics, and their physics identities specifically. NSF Grant No. 1036617.

Pursuit of communal values in an agentic manner: a way to happiness?

PubMed Central

Abele, Andrea E.

2014-01-01

The present research studies the association between traits, values, and life satisfaction. While values should influence the direction of an individual’s goals and behavior, his/her traits impact effort-expenditure, efficiency, and persistence in goal-pursuit. We apply the framework of the “Big Two” of agency and communion (Bakan, 1966) for distinguishing the content of values and traits. While agentic content refers to qualities relevant for goal-attainment, such as assertiveness, competence or persistence, communal content refers to qualities relevant for the establishment and maintenance of social relationships, such as being friendly, helpful, or fair. We predict that high scores on communal values and high scores on agentic traits are associated with life satisfaction. We test these predictions in two studies conducted in different countries (Germany and Russia) with different cultural background. The findings support our reasoning: across both countries we find positive associations of communal values and agentic traits with life satisfaction; and individuals high in communal values and high in agentic traits are most satisfied with their lives. In Russia, the association of communal values with life satisfaction is moderated by agentic traits; in Germany, however, there is a main effect of communal values. PMID:25477843

Perfluorocarboxylic acid (PFCA) atmospheric formation and transport to the Arctic.

NASA Astrophysics Data System (ADS)

Pike-thackray, C.; Selin, N. E.

2015-12-01

Perfluorocarboxylic acids (PFCAs) are highly persistent and toxic environmental contaminants that have been found in remote locations such as the Arctic, far from emission sources. These persistent organic pollutants are emitted directly to the atmosphere as well as being produced by the degradation of precursor compounds in the atmosphere, but recent trends towards increasing precursor emissions and decreasing direct emissions raise the importance of production in the atmosphere. Our work aims to improve understanding of the atmospheric degradation of fluorotelomer precursor compounds to form the long-chain PFCAs PFOA (C8) and PFNA (C9).Using the atmospheric chemical transport model GEOS-Chem, which uses assimilated meteorology to simulate the atmospheric transport of trace gas species, we investigate the interaction of the atmospheric formation of PFCAs and the atmospheric transport of their precursor species. Our simulations are a first application of the GEOS-Chem framework to PFCA chemistry. We highlight the importance of the spatial and temporal variability of background atmospheric chemical conditions experienced during transport. We find that yields and formation times of PFOA and PFNA respond differently and strongly to the photochemical conditions of the atmosphere, such as the abundance of NO, HO2, and other photochemical species.

Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering.

PubMed

Metzger, F Luise; Auer, Tibor; Helms, Gunther; Paulus, Walter; Frahm, Jens; Sommer, Martin; Neef, Nicole E

2018-01-01

Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.

Conservation biogeography of the Cerrado's wild edible plants under climate change: Linking biotic stability with agricultural expansion.

PubMed

de Oliveira, Guilherme; Lima-Ribeiro, Matheus Souza; Terribile, Levi Carina; Dobrovolski, Ricardo; Telles, Mariana Pires de Campos; Diniz-Filho, José Alexandre Felizola

2015-06-01

REMISE OF THE STUDY: Wild edible plants (WEPs) have an important cultural and economic role in human population worldwide. Human impacts are quickly converting natural habitats in agricultural, cattle ranch, and urbanized lands, putting native species on peril of risk of extinction, including some WEPs. Moreover, global climate changes also can pose another threat to species persistency. Here, we established conservation priorities for the Cerrado, a neotropical region in South America with high levels of plant endemism and vulnerability, aiming to assure long-term persistency of 16 most important WEPs. We evaluated these conservation priorities using a conservation biogeography framework using ecological patterns and process at a biogeographical scale to deal with species conservation features. We built ecological niche models for 16 WEPs from Cerrado in the neotropics using climate models for preindustrial, past (Last Glacial Maximum) and future (year 2080) time periods to establish climatically stable areas through time, finding refugias for these WEPs. We used a spatial prioritization algorithm based on the spatial pattern of irreplaceability across the neotropics, aiming to ensure the persistence of at least 25% of range size in climatically stable areas for each WEP, using agricultural models as constraints. The Southeast Cerrado was the most biotically stable and irreplaceable region for the WEPs compared with other areas across the neotropics. Our findings strongly suggest that the Southeast Cerrado should be considered a conservation priority, with new protected areas to be sustainably managed and restored, to guarantee the supply of cultural and ecosystem services provided from the Cerrado's WEPs. © 2015 Botanical Society of America, Inc.

A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts.

PubMed

Sakashita, Tetsuya; Hamada, Nobuyuki; Kawaguchi, Isao; Hara, Takamitsu; Kobayashi, Yasuhiko; Saito, Kimiaki

2014-05-01

A single cell can form a colony, and ionizing irradiation has long been known to reduce such a cellular clonogenic potential. Analysis of abortive colonies unable to continue to grow should provide important information on the reproductive cell death (RCD) following irradiation. Our previous analysis with a branching process model showed that the RCD in normal human fibroblasts can persist over 16 generations following irradiation with low linear energy transfer (LET) γ-rays. Here we further set out to evaluate the RCD persistency in abortive colonies arising from normal human fibroblasts exposed to high-LET carbon ions (18.3 MeV/u, 108 keV/µm). We found that the abortive colony size distribution determined by biological experiments follows a linear relationship on the log-log plot, and that the Monte Carlo simulation using the RCD probability estimated from such a linear relationship well simulates the experimentally determined surviving fraction and the relative biological effectiveness (RBE). We identified the short-term phase and long-term phase for the persistent RCD following carbon-ion irradiation, which were similar to those previously identified following γ-irradiation. Taken together, our results suggest that subsequent secondary or tertiary colony formation would be invaluable for understanding the long-lasting RCD. All together, our framework for analysis with a branching process model and a colony formation assay is applicable to determination of cellular responses to low- and high-LET radiation, and suggests that the long-lasting RCD is a pivotal determinant of the surviving fraction and the RBE.

Comparing patterns and predictors of immigrant offending among a sample of adjudicated youth.

PubMed

Bersani, Bianca E; Loughran, Thomas A; Piquero, Alex R

2014-11-01

Research on immigration and crime has only recently started to consider potential heterogeneity in longitudinal patterns of immigrant offending. Guided by segmented assimilation and life course criminology frameworks, this article advances prior research on the immigration-crime nexus in three ways: using a large sample of high-risk adjudicated youth containing first and second generation immigrants; examining longitudinal trajectories of official and self-reported offending; and merging segmented assimilation and life course theories to distinguish between offending patterns. Data come from the Pathways to Desistance study containing detailed offending and socio-demographic background information on 1,354 adolescents (13.6 % female; n = 1,061 native-born; n = 210 second generation immigrants; n = 83 first generation immigrants) as they transition to young adulthood (aged 14-17 at baseline). Over 84 months we observe whether patterns of offending, and the correlates that may distinguish them, operate differently across immigrant generations. Collectively, this study offers the first investigation of whether immigrants, conditioned on being adjudicated, are characterized by persistent offending. Results show that first generation immigrants are less likely to be involved in serious offending and to evidence persistence in offending, and appear to be on a path toward desistance much more quickly than their peers. Further, assimilation and neighborhood disadvantage operate in unique ways across generational status and relate to different offending styles. The findings show that the risk for persistent offending is greatest among those with high levels of assimilation who reside in disadvantaged contexts, particularly among the second generation youth in the sample.

Reliable and Persistent Identification of Linked Data Elements

NASA Astrophysics Data System (ADS)

Wood, David

Linked Data techniques rely upon common terminology in a manner similar to a relational database'vs reliance on a schema. Linked Data terminology anchors metadata descriptions and facilitates navigation of information. Common vocabularies ease the human, social tasks of understanding datasets sufficiently to construct queries and help to relate otherwise disparate datasets. Vocabulary terms must, when using the Resource Description Framework, be grounded in URIs. A current bestpractice on the World Wide Web is to serve vocabulary terms as Uniform Resource Locators (URLs) and present both human-readable and machine-readable representations to the public. Linked Data terminology published to theWorldWideWeb may be used by others without reference or notification to the publishing party. That presents a problem: Vocabulary publishers take on an implicit responsibility to maintain and publish their terms via the URLs originally assigned, regardless of the inconvenience such a responsibility may cause. Over the course of years, people change jobs, publishing organizations change Internet domain names, computers change IP addresses,systems administrators publish old material in new ways. Clearly, a mechanism is required to manageWeb-based vocabularies over a long term. This chapter places Linked Data vocabularies in context with the wider concepts of metadata in general and specifically metadata on the Web. Persistent identifier mechanisms are reviewed, with a particular emphasis on Persistent URLs, or PURLs. PURLs and PURL services are discussed in the context of Linked Data. Finally, historic weaknesses of PURLs are resolved by the introduction of a federation of PURL services to address needs specific to Linked Data.

Working group on future trends

USGS Publications Warehouse

,; O'Shea, Thomas J.; Reeves, Randall R.; Long, Alison Kirk

1999-01-01

This working group did not divide into subgroups, and its report consists of a unified document in a format somewhat different than those of the other working groups. The group considered four major topics: (1) projected "new" contaminants of future concern; (2) future trends with contaminants currently known to be issues for marine mammals; (3) future needs to improve and insure consistency of sample collection and analyses; and (4) future management needs.The problems of persistent organic pollutants will remain well into the foreseeable future. A general decline in levels of persistent organic pollutants in the marine environment is not anticipated. there is every likelihood that the environmental trends of halogenated organic compounds, such as polybromated diphenyl ethers and chlorinated paraffins, will parallel production trends, as demonstrated with well known chemical contaminants such as PCBs (polychlorinated biphenyls) and DDT (dichlorodiphenyltrichloroethane). While the environmental levels of some compounds may be slowly declining, many are still within the ranges where subtle toxic effects are to be anticipated. Trends in contaminants must be placed in a regional context, and rates and directions of change are often region-specific. For example, in the Southern Hemisphere the concentrations of PCBs appear to be increasing. The rates of change of many contaminants in the Southern hemisphere are poorly known, and this region may be at future risk.Much of the research on contaminants and marine mammals has focused on the problem of persistent organochloride chemicals such as PCBs and DDT, which are a continuing and global problem. Potential problems caused by other persistent, toxic, and bioaccumulative substances (PTBSs) cannot currently be addressed due to the lack of basic information on their production, use, exposure, and effects (Environmental Protection Agency 1998). It is currently estimated that there are roughly 2400 lipophilic and persistent chemicals, of which 390 are PTBSs. In order to prevent long-term pollution from these largely unknown chemicals, chemical industries should disclose basic information on such compounds, and this information should be made widely available. This will require enhanced international cooperation, preferably within the existing framework of chemical contaminant programs, such as the Existing Chemicals Program of the Organization for Economic Cooperation and Development (1991) and the Program on persistent Organic Pollutants of the United National Environmental Programme (1998).Monitoring studies are essential to the description and understanding of pollutants. It is necessary to exploit existing analytical techniques to identify as many anthropogenic compounds as possible in marine mammal tissues in order to expand the identification of existing and new chemicals that accumulate in, and pose threats to, these species.

Steady and transient sliding under rate-and-state friction

NASA Astrophysics Data System (ADS)

Putelat, Thibaut; Dawes, Jonathan H. P.

2015-05-01

The physics of dry friction is often modelled by assuming that static and kinetic frictional forces can be represented by a pair of coefficients usually referred to as μs and μk, respectively. In this paper we re-examine this discontinuous dichotomy and relate it quantitatively to the more general, and smooth, framework of rate-and-state friction. This is important because it enables us to link the ideas behind the widely used static and dynamic coefficients to the more complex concepts that lie behind the rate-and-state framework. Further, we introduce a generic framework for rate-and-state friction that unifies different approaches found in the literature. We consider specific dynamical models for the motion of a rigid block sliding on an inclined surface. In the Coulomb model with constant dynamic friction coefficient, sliding at constant velocity is not possible. In the rate-and-state formalism steady sliding states exist, and analysing their existence and stability enables us to show that the static friction coefficient μs should be interpreted as the local maximum at very small slip rates of the steady state rate-and-state friction law. Next, we revisit the often-cited experiments of Rabinowicz (J. Appl. Phys., 22:1373-1379, 1951). Rabinowicz further developed the idea of static and kinetic friction by proposing that the friction coefficient maintains its higher and static value μs over a persistence length before dropping to the value μk. We show that there is a natural identification of the persistence length with the distance that the block slips as measured along the stable manifold of the saddle point equilibrium in the phase space of the rate-and-state dynamics. This enables us explicitly to define μs in terms of the rate-and-state variables and hence link Rabinowicz's ideas to rate-and-state friction laws. This stable manifold naturally separates two basins of attraction in the phase space: initial conditions in the first one lead to the block eventually stopping, while in the second basin of attraction the sliding motion continues indefinitely. We show that a second definition of μs is possible, compatible with the first one, as the weighted average of the rate-and-state friction coefficient over the time the block is in motion.

Tobacco smoking: the leading cause of preventable disease worldwide.

PubMed

Samet, Jonathan M

2013-05-01

Tobacco smoking is the world's leading cause of avoidable premature mortality, reflecting the potent toxicity of tobacco smoke inhaled by smokers for decades. In the twentieth century, lung cancer was an early sentinel of the emergence of the still persisting epidemic of tobacco-caused disease. Smoking has declined in many countries, particularly the high-income countries, but low- and middle-income countries remain at risk because of the aggressive tactics of tobacco multinationals. The World Health Organization treaty, the Framework Convention on Tobacco Control, is a critical factor in countering these tactics and precipitating the end of the global epidemic of tobacco smoking. Copyright © 2013 Elsevier Inc. All rights reserved.

Impact of information and communication technology on child health.

PubMed

Woo, Eugenia Hc; White, Peter; Lai, Christopher Wk

2016-06-01

This article provides a general framework for understanding the use of information and communication technology in education and discusses the impact of computer usage on students' health and development. Potential beneficial and harmful effects of computer use by children are discussed. Early epidemiological and laboratory studies have indicated that children are at least of similar risk of developing musculoskeletal and vision problems as adults, and musculoskeletal and visual health problems developed in childhood are likely to persist into adulthood. This article, therefore, aims to provide a reflection on the deficits of existing policy and recommendations for child-specific guidelines in computer use. © 2016 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

Ecological research and environmental management: We need different interfaces based on different knowledge types.

PubMed

Gosselin, Frédéric; Cordonnier, Thomas; Bilger, Isabelle; Jappiot, Marielle; Chauvin, Christophe; Gosselin, Marion

2018-04-25

The role of ecological science in environmental management has been discussed by many authors who recognize that there is a persistent gap between ecological science and environmental management. Here we develop theory through different perspectives based on knowledge types, research categories and research-management interface types, which we combine into a common framework. To draw out insights for bridging this gap, we build our case by:We point out the complementarities as well as the specificities and limitations of the different types of ecological research, ecological knowledge and research-management interfaces, which is of major importance for environmental management and research policies. Copyright © 2018 Elsevier Ltd. All rights reserved.

Breaking the Intergenerational Cycle of Disadvantage: The Three Generation Approach

PubMed Central

Johnson, Sara B.; Goodman, Elizabeth

2016-01-01

Health disparities in the United States related to socioeconomic status are persistent and pervasive. This review highlights how social disadvantage, particularly low socioeconomic status and the health burden it brings, is passed from 1 generation to the next. First, we review current frameworks for understanding the intergenerational transmission of health disparities and provide 4 illustrative examples relevant to child health, development, and well-being. Second, the leading strategy to break the cycle of poverty in young families in the United States, the 2-generation approach, is reviewed. Finally, we propose a new 3-generation approach that must combine with the 2-generation approach to interrupt the intergenerational cycle of disadvantage and eliminate health disparities. PMID:27244844

MCdevelop - a universal framework for Stochastic Simulations

NASA Astrophysics Data System (ADS)

Slawinska, M.; Jadach, S.

2011-03-01

We present MCdevelop, a universal computer framework for developing and exploiting the wide class of Stochastic Simulations (SS) software. This powerful universal SS software development tool has been derived from a series of scientific projects for precision calculations in high energy physics (HEP), which feature a wide range of functionality in the SS software needed for advanced precision Quantum Field Theory calculations for the past LEP experiments and for the ongoing LHC experiments at CERN, Geneva. MCdevelop is a "spin-off" product of HEP to be exploited in other areas, while it will still serve to develop new SS software for HEP experiments. Typically SS involve independent generation of large sets of random "events", often requiring considerable CPU power. Since SS jobs usually do not share memory it makes them easy to parallelize. The efficient development, testing and running in parallel SS software requires a convenient framework to develop software source code, deploy and monitor batch jobs, merge and analyse results from multiple parallel jobs, even before the production runs are terminated. Throughout the years of development of stochastic simulations for HEP, a sophisticated framework featuring all the above mentioned functionality has been implemented. MCdevelop represents its latest version, written mostly in C++ (GNU compiler gcc). It uses Autotools to build binaries (optionally managed within the KDevelop 3.5.3 Integrated Development Environment (IDE)). It uses the open-source ROOT package for histogramming, graphics and the mechanism of persistency for the C++ objects. MCdevelop helps to run multiple parallel jobs on any computer cluster with NQS-type batch system. Program summaryProgram title:MCdevelop Catalogue identifier: AEHW_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEHW_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 48 136 No. of bytes in distributed program, including test data, etc.: 355 698 Distribution format: tar.gz Programming language: ANSI C++ Computer: Any computer system or cluster with C++ compiler and UNIX-like operating system. Operating system: Most UNIX systems, Linux. The application programs were thoroughly tested under Ubuntu 7.04, 8.04 and CERN Scientific Linux 5. Has the code been vectorised or parallelised?: Tools (scripts) for optional parallelisation on a PC farm are included. RAM: 500 bytes Classification: 11.3 External routines: ROOT package version 5.0 or higher ( http://root.cern.ch/drupal/). Nature of problem: Developing any type of stochastic simulation program for high energy physics and other areas. Solution method: Object Oriented programming in C++ with added persistency mechanism, batch scripts for running on PC farms and Autotools.

How best practices are copied, transferred, or translated between health care facilities: A conceptual framework.

PubMed

Guzman, Gustavo; Fitzgerald, Janna Anneke; Fulop, Liz; Hayes, Kathryn; Poropat, Arthur; Avery, Mark; Campbell, Steve; Fisher, Ron; Gapp, Rod; Herington, Carmel; McPhail, Ruth; Vecchio, Nerina

2015-01-01

In spite of significant investment in quality programs and activities, there is a persistent struggle to achieve quality outcomes and performance improvements within the constraints and support of sociopolitical parsimonies. Equally, such constraints have intensified the need to better understand the best practice methods for achieving quality improvements in health care organizations over time.This study proposes a conceptual framework to assist with strategies for the copying, transferring, and/or translation of best practice between different health care facilities. Applying a deductive logic, the conceptual framework was developed by blending selected theoretical lenses drawn from the knowledge management and organizational learning literatures. The proposed framework highlighted that (a) major constraints need to be addressed to turn best practices into everyday practices and (b) double-loop learning is an adequate learning mode to copy and to transfer best practices and deuteron learning mode is a more suitable learning mode for translating best practice. We also found that, in complex organizations, copying, transferring, and translating new knowledge is more difficult than in smaller, less complex organizations. We also posit that knowledge translation cannot happen without transfer and copy, and transfer cannot happen without copy of best practices. Hence, an integration of all three learning processes is required for knowledge translation (copy best practice-transfer knowledge about best practice-translation of best practice into new context). In addition, the higher the level of complexity of the organization, the more best practice is tacit oriented and, in this case, the higher the level of K&L capabilities are required to successfully copy, transfer, and/or translate best practices between organizations. The approach provides a framework for assessing organizational context and capabilities to guide copy/transfer/translation of best practices. A roadmap is provided to assist managers and practitioners to select appropriate learning modes for building success and positive systemic change.

Inferring the nature of anthropogenic threats from long-term abundance records.

PubMed

Shoemaker, Kevin T; Akçakaya, H Resit

2015-02-01

Diagnosing the processes that threaten species persistence is critical for recovery planning and risk forecasting. Dominant threats are typically inferred by experts on the basis of a patchwork of informal methods. Transparent, quantitative diagnostic tools would contribute much-needed consistency, objectivity, and rigor to the process of diagnosing anthropogenic threats. Long-term census records, available for an increasingly large and diverse set of taxa, may exhibit characteristic signatures of specific threatening processes and thereby provide information for threat diagnosis. We developed a flexible Bayesian framework for diagnosing threats on the basis of long-term census records and diverse ancillary sources of information. We tested this framework with simulated data from artificial populations subjected to varying degrees of exploitation and habitat loss and several real-world abundance time series for which threatening processes are relatively well understood: bluefin tuna (Thunnus maccoyii) and Atlantic cod (Gadus morhua) (exploitation) and Red Grouse (Lagopus lagopus scotica) and Eurasian Skylark (Alauda arvensis) (habitat loss). Our method correctly identified the process driving population decline for over 90% of time series simulated under moderate to severe threat scenarios. Successful identification of threats approached 100% for severe exploitation and habitat loss scenarios. Our method identified threats less successfully when threatening processes were weak and when populations were simultaneously affected by multiple threats. Our method selected the presumed true threat model for all real-world case studies, although results were somewhat ambiguous in the case of the Eurasian Skylark. In the latter case, incorporation of an ancillary source of information (records of land-use change) increased the weight assigned to the presumed true model from 70% to 92%, illustrating the value of the proposed framework in bringing diverse sources of information into a common rigorous framework. Ultimately, our framework may greatly assist conservation organizations in documenting threatening processes and planning species recovery. © 2014 Society for Conservation Biology.

Is an ecosystem services-based approach developed for setting specific protection goals for plant protection products applicable to other chemicals?

PubMed

Maltby, Lorraine; Jackson, Mathew; Whale, Graham; Brown, A Ross; Hamer, Mick; Solga, Andreas; Kabouw, Patrick; Woods, Richard; Marshall, Stuart

2017-02-15

Clearly defined protection goals specifying what to protect, where and when, are required for designing scientifically sound risk assessments and effective risk management of chemicals. Environmental protection goals specified in EU legislation are defined in general terms, resulting in uncertainty in how to achieve them. In 2010, the European Food Safety Authority (EFSA) published a framework to identify more specific protection goals based on ecosystem services potentially affected by plant protection products. But how applicable is this framework to chemicals with different emission scenarios and receptor ecosystems? Four case studies used to address this question were: (i) oil refinery waste water exposure in estuarine environments; (ii) oil dispersant exposure in aquatic environments; (iii) down the drain chemicals exposure in a wide range of ecosystems (terrestrial and aquatic); (iv) persistent organic pollutant exposure in remote (pristine) Arctic environments. A four-step process was followed to identify ecosystems and services potentially impacted by chemical emissions and to define specific protection goals. Case studies demonstrated that, in principle, the ecosystem services concept and the EFSA framework can be applied to derive specific protection goals for a broad range of chemical exposure scenarios. By identifying key habitats and ecosystem services of concern, the approach offers the potential for greater spatial and temporal resolution, together with increased environmental relevance, in chemical risk assessments. With modifications including improved clarity on terminology/definitions and further development/refinement of the key concepts, we believe the principles of the EFSA framework could provide a methodical approach to the identification and prioritization of ecosystems, ecosystem services and the service providing units that are most at risk from chemical exposure. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Health systems frameworks in their political context: framing divergent agendas

PubMed Central

2012-01-01

Background Despite the mounting attention for health systems and health systems theories, there is a persisting lack of consensus on their conceptualisation and strengthening. This paper contributes to structuring the debate, presenting landmarks in the development of health systems thinking against the backdrop of the policy context and its dominant actors. We argue that frameworks on health systems are products of their time, emerging from specific discourses. They are purposive, not neutrally descriptive, and are shaped by the agendas of their authors. Discussion The evolution of thinking over time does not reflect a progressive accumulation of insights. Instead, theories and frameworks seem to develop in reaction to one another, partly in line with prevailing paradigms and partly as a response to the very different needs of their developers. The reform perspective considering health systems as projects to be engineered is fundamentally different from the organic view that considers a health system as a mirror of society. The co-existence of health systems and disease-focused approaches indicates that different frameworks are complementary but not synthetic. The contestation of theories and methods for health systems relates almost exclusively to low income countries. At the global level, health system strengthening is largely narrowed down to its instrumental dimension, whereby well-targeted and specific interventions are supposed to strengthen health services and systems or, more selectively, specific core functions essential to programmes. This is in contrast to a broader conceptualization of health systems as social institutions. Summary Health systems theories and frameworks frame health, health systems and policies in particular political and public health paradigms. While there is a clear trend to try to understand the complexity of and dynamic relationships between elements of health systems, there is also a demand to provide frameworks that distinguish between health system interventions, and that allow mapping with a view of analysing their returns. The choice for a particular health system model to guide discussions and work should fit the purpose. The understanding of the underlying rationale of a chosen model facilitates an open dialogue about purpose and strategy. PMID:22971107

Towards a comparable carbon footprint for local initiatives: The FP7 project TESS

NASA Astrophysics Data System (ADS)

Reusser, Dominik E.; Kropp, Jürgen P.

2014-05-01

TESS (Towards European Societal Sustainability -- www.tess-transition.eu) is a three-year, European-wide research project. It aims to reach an understanding of the potential for community-led initiatives to help deliver a truly sustainable, low-carbon future. Transitions to low-carbon societies take place at multiple and complementary scales. Transition processes are highly dependent on the innovative potential of community-based initiatives and their articulation with appropriate institutional architecture. Community-based initiatives are potentially more adaptable and less constrained by current structural circumstances than top-down policies and can give impetus to large-scale and technology driven changes. TESS will provide an understanding on the upscaling possibilities of such high-potential community-based initiatives by addressing two main questions: What is the impact of community-based initiatives in terms of carbon reduction potential and economic effect? What institutional structures (values, policies and mechanisms) support these initiatives in persisting beyond the initial phase and moving into an acceleration phase, spreading desired impacts? Answers will be provided through (1) a novel measuring, reporting and verification (MRV) framework for benchmarking community-based initiatives. This will enable quantifiable, comparable and standardised evaluation, and (2) the identification of success factors for the emergence, persistence and diffusion of promising initiatives, including online initiatives. We will identify these initiatives through case studies across regions and sectors and produce a systemic understanding of their impact on societal transitions towards sustainability. Our research will be integrated and transdisciplinary, with the unique opportunity to bring together social and natural scientists to foster a transition towards European societal sustainability. Our work will feed into and extend the Climate Adapt database to facilitate reconciliation of mitigation and adaptation and connect to Europe wide evaluation approaches such as the Common Monitoring and Evaluation Framework (CMEF) of the Rural Development Programmes. The poster will show the current state of the initiative selection process and of the method development.

Economy and job contract as contexts of sickness absence practices: revisiting locality and habitus.

PubMed

Virtanen, P; Vahtera, J; Nakari, R; Pentti, J; Kivimäki, M

2004-04-01

This study revisits two Finnish local governments-Raisio and Nokia-that in an earlier study showed different sickness absence rates in the early 1990s. The locality difference was interpreted sociologically, within a framework inspired by Bourdieu's theory of social field, habitus and practice. The same framework is applied in the present study, starting out from the hypothesis that a constant historical and cultural locality context tends to reproduce prevailing sickness absence practices. The hypothesis was tested by extending the context beyond the locality to the macroeconomic fluctuations that occurred during the 1990s and to the type of employment contract. In both localities a 30% rise was observed in levels of sickness absence from 1991-1993 to 1997-2000. At the beginning of the 1990s the absence rate among permanent employees was 1.86 times higher in Nokia than in Raisio; at the end of the decade the corresponding rate ratio was 1.88. The absence rates were significantly lower among fixed-term employees than permanent employees, but the locality difference was seen in their case, too. Both results support the hypothesis. In spite of major changes taking place in the national economy, the differences between the two towns' sickness absence rates persisted, which in this particular case probably reflects the persisting working-class character of Nokia and middle-class character of Raisio. The theory also applies to the difference between permanent and fixed-term employees: the peripheral power position of the latter on work related social fields leads to the observed practices, i.e. to the relatively low absence rate. The results of our revisit give reason to recapitulate and elaborate upon our theoretical interpretation with a view to deepening our understanding of the social origins of sickness absence practices in the post-industrial workplace, which is characterised by increasing atypical employment and growing job insecurity.

Modeling Novelty Habituation During Exploratory Activity in Drosophila

PubMed Central

Soibam, Benjamin; Shah, Shishir; Gunaratne, Gemunu H.; Roman, Gregg W.

2013-01-01

Habituation is a common form of non-associative learning in which the organism gradually decreases its response to repeated stimuli. The decrease in exploratory activity of many animal species during exposure to a novel open field arena is a widely studied habituation paradigm. However, a theoretical framework to quantify how the novelty of the arena is learned during habituation is currently missing. Drosophila melanogaster display a high mean absolute activity and a high probability for directional persistence when first introduced to a novel arena. Both measures decrease during habituation to the arena. Here, we propose a phenomenological model of habituation for Drosophila exploration based on two principles: Drosophila form a spatial representation of the arena edge as a set of connected local patches, and repeated exposure to these patches is essential for the habituation of the novelty. The level of exposure depends on the number of visitations and is quantified by a variable referred to as “coverage.” This model was tested by comparing predictions against the experimentally measured behavior of wild type Drosophila. The novelty habituation of wild type Canton-S depends on coverage and is specifically independent of the arena radius. Our model describes the time dependent locomotor activity, ΔD, of Canton-S using an experimentally established stochastic process Pn(ΔD) which depends on the coverage. The quantitative measures of exploration and habituation were further applied to three mutant genotypes. Consistent with a requirement for vision in novelty habituation, blind no receptor potential A7 mutants display a failure in the decay of probability for directional persistence and mean absolute activity. The rutabaga2080 habituation mutant also shows defects in these measures. The kurtz1 non-visual arrestin mutant demonstrates a rapid decay in these measures, implying reduced motivation. The model and the habituation measures offer a powerful framework for understanding mechanisms associated with open field habituation. PMID:23597866

Physical Samples Linked Data in Action

NASA Astrophysics Data System (ADS)

Ji, P.; Arko, R. A.; Lehnert, K.; Bristol, S.

2017-12-01

Most data and metadata related to physical samples currently reside in isolated relational databases driven by diverse data models. How to approach the challenge for sharing, interchanging and integrating data from these difference relational databases motivated us to publish Linked Open Data for collections of physical samples, using Semantic Web technologies including the Resource Description Framework (RDF), RDF Query Language (SPARQL), and Web Ontology Language (OWL). In last few years, we have released four knowledge graphs concentrated on physical samples, including System for Earth Sample Registration (SESAR), USGS National Geochemical Database (NGDC), Ocean Biogeographic Information System (OBIS), and Earthchem Database. Currently the four knowledge graphs contain over 12 million facets (triples) about objects of interest to the geoscience domain. Choosing appropriate domain ontologies for representing context of data is the core of the whole work. Geolink ontology developed by Earthcube Geolink project was used as top level to represent common concepts like person, organization, cruise, etc. Physical sample ontology developed by Interdisciplinary Earth Data Alliance (IEDA) and Darwin Core vocabulary were used as second level to describe details about geological samples and biological diversity. We also focused on finding and building best tool chains to support the whole life cycle of publishing linked data we have, including information retrieval, linked data browsing and data visualization. Currently, Morph, Virtuoso Server, LodView, LodLive, and YASGUI were employed for converting, storing, representing, and querying data in a knowledge base (RDF triplestore). Persistent digital identifier is another main point we concentrated on. Open Researcher & Contributor IDs (ORCIDs), International Geo Sample Numbers (IGSNs), Global Research Identifier Database (GRID) and other persistent identifiers were used to link different resources from various graphs with person, sample, organization, cruise, etc. This work is supported by the EarthCube "GeoLink" project (NSF# ICER14-40221 and others) and the "USGS-IEDA Partnership to Support a Data Lifecycle Framework and Tools" project (USGS# G13AC00381).

Imbalanced decision hierarchy in addicts emerging from drug-hijacked dopamine spiraling circuit.

PubMed

Keramati, Mehdi; Gutkin, Boris

2013-01-01

Despite explicitly wanting to quit, long-term addicts find themselves powerless to resist drugs, despite knowing that drug-taking may be a harmful course of action. Such inconsistency between the explicit knowledge of negative consequences and the compulsive behavioral patterns represents a cognitive/behavioral conflict that is a central characteristic of addiction. Neurobiologically, differential cue-induced activity in distinct striatal subregions, as well as the dopamine connectivity spiraling from ventral striatal regions to the dorsal regions, play critical roles in compulsive drug seeking. However, the functional mechanism that integrates these neuropharmacological observations with the above-mentioned cognitive/behavioral conflict is unknown. Here we provide a formal computational explanation for the drug-induced cognitive inconsistency that is apparent in the addicts' "self-described mistake". We show that addictive drugs gradually produce a motivational bias toward drug-seeking at low-level habitual decision processes, despite the low abstract cognitive valuation of this behavior. This pathology emerges within the hierarchical reinforcement learning framework when chronic exposure to the drug pharmacologically produces pathologicaly persistent phasic dopamine signals. Thereby the drug hijacks the dopaminergic spirals that cascade the reinforcement signals down the ventro-dorsal cortico-striatal hierarchy. Neurobiologically, our theory accounts for rapid development of drug cue-elicited dopamine efflux in the ventral striatum and a delayed response in the dorsal striatum. Our theory also shows how this response pattern depends critically on the dopamine spiraling circuitry. Behaviorally, our framework explains gradual insensitivity of drug-seeking to drug-associated punishments, the blocking phenomenon for drug outcomes, and the persistent preference for drugs over natural rewards by addicts. The model suggests testable predictions and beyond that, sets the stage for a view of addiction as a pathology of hierarchical decision-making processes. This view is complementary to the traditional interpretation of addiction as interaction between habitual and goal-directed decision systems.

Applying a dryland degradation framework for rangelands: the case of Mongolia.

PubMed

Jamsranjav, C; Reid, R S; Fernández-Giménez, M E; Tsevlee, A; Yadamsuren, B; Heiner, M

2018-04-01

Livestock-caused rangeland degradation remains a major policy concern globally and the subject of widespread scientific study. This concern persists in part because it is difficult to isolate the effects of livestock from climate and other factors that influence ecosystem conditions. Further, degradation studies seldom use multiple plant and soil indicators linked to a clear definition of and ecologically grounded framework for degradation assessment that distinguishes different levels of degradation. Here, we integrate two globally applicable rangeland degradation frameworks and apply them to a broad-scale empirical data set for the country of Mongolia. We compare our assessment results with two other recent national rangeland degradation assessments in Mongolia to gauge consistency of findings across assessments and evaluate the utility of our framework. We measured livestock-use impacts across Mongolia's major ecological zones: mountain and forest steppe, eastern steppe, steppe, and desert steppe. At 143 sites in 36 counties, we measured livestock-use and degradation indicators at increasing distances from livestock corrals in winter-grazed pastures. At each site, we measured multiple indicators linked to our degradation framework, including plant cover, standing biomass, palatability, species richness, forage quality, vegetation gaps, and soil surface characteristics. Livestock use had no effect on soils, plant species richness, or standing crop biomass in any ecological zone, but subtly affected plant cover and palatable plant abundance. Livestock effects were strongest in the steppe zone, moderate in the desert steppe, and limited in the mountain/forest and eastern steppes. Our results aligned closely with those of two other recent country-wide assessments, suggesting that our framework may have widespread application. All three assessments found that very severe and irreversible degradation is rare in Mongolia (1-18% of land area), with most rangelands slightly (33-53%) or moderately (25-40%) degraded. We conclude that very severe livestock-induced rangeland degradation is overstated in Mongolia. However, targeted rangeland restoration coupled with monitoring, adaptive management and stronger rangeland governance are needed to prevent further degradation where heavy grazing could cause irreversible change. Given the broad applicability of our degradation framework for Mongolia, we suggest it be tested for application in other temperate grasslands throughout Central Asia and North America. © 2018 The Authors Ecological Applications published by Wiley Periodicals, Inc. on behalf of Ecological Society of America.

Space Shuttle Hot Cabin Emergency Responses

NASA Technical Reports Server (NTRS)

Stepaniak, P.; Effenhauser, R. K.; McCluskey, R.; Gillis, D. B.; Hamilton, D.; Kuznetz, L. H.

2005-01-01

Methods: Human thermal tolerance, countermeasures, and thermal model data were reviewed and compared to existing shuttle ECS failure temperature and humidity profiles for each failure mode. Increases in core temperature associated with cognitive impairment was identified, as was metabolic heat generation of crewmembers, temperature monitoring, and communication capabilities after partial power-down and other limiting factors. Orbiter landing strategies and a hydration and salt replacement protocol were developed to put wheels on deck in each failure mode prior to development of significant cognitive impairment or collapse of crewmembers. Thermal tradeoffs for use of the Advanced Crew Escape Suit (ACES), Liquid Cooling Garment, integrated G-suit and Quick Don Mask were examined. candidate solutions involved trade-offs or conflicts with cabin oxygen partial pressure limits, system power-downs to limit heat generation, risks of alternate and emergency landing sites or compromise of Mode V-VIII scenarios. Results: Rehydration and minimized cabin workloads are required in all failure modes. Temperature/humidity profiles increase rapidly in two failure modes, and deorbit is recommended without the ACES, ICU and g-suit. This latter configuration limits several shuttle approach and landing escape modes and requires communication modifications. Additional data requirements were identified and engineering simulations were recommended to develop more current shuttle temperature and humidity profiles. Discussion: After failure of the shuttle ECS, there is insufficient cooling capacity of the ACES to protect crewmembers from rising cabin temperature and humidity. The LCG is inadequate for cabin temperatures above 76 F. Current shuttle future life policy makes it unlikely that major engineering upgrades necessary to address this problem will occur.