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Sample records for le porc sus

  1. [Structural recovering in Andean successional forests from Porce (Antioquia, Colombia)].

    PubMed

    Yepes, Adriana P; del Valle, Jorge I; Jaramillo, Sandra L; Orrego, Sergio A

    2010-03-01

    Places subjected to natural or human disturbance can recover forest through an ecological process called secondary succession. Tropical succession is affected by factors such as disturbances, distance from original forest, surface configuration and local climate. These factors determine the composition of species and the time trend of the succession itself. We studied succession in soils used for cattle ranching over various decades in the Porce Region of Colombia (Andean Colombian forests). A set of twenty five permanent plots was measured, including nine plots (20 x 50 m) in primary forests and sixteen (20 x 25 m) in secondary forests. All trees with diameter > or =1.0 cm were measured. We analyzed stem density, basal area, above-ground biomass and species richness, in a successional process of ca. 43 years, and in primary forests. The secondary forests' age was estimated in previous studies, using radiocarbon dating, aerial photographs and a high-resolution satellite image analysis (7 to >43 years). In total, 1,143 and 1,766 stems were measured in primary and secondary forests, respectively. Basal area (5.7 to 85.4 m2 ha(-1)), above-ground biomass (19.1 to 1,011.5 t ha(-1)) and species richness (4 to 69) directly increased with site age, while steam density decreased (3,180 to 590). Diametric distributions were "J-inverted" for primary forests and even-aged size-class structures for secondary forests. Three species of palms were abundant and exclusive in old secondary forests and primary forests: Oenocarpus mapora, Euterpe precatoria and Oenocarpus bataua. These palms happened in cohorts after forest disturbances. Secondary forest structure was 40% in more than 43 years of forest succession and indicate that many factors are interacting and affecting the forests succession in the area (e.g. agriculture, cattle ranching, mining, etc.).

  2. Arabidopsis protochlorophyllide oxidoreductase A (PORA) restores bulk chlorophyll synthesis and normal development to a porB porC double mutant.

    PubMed

    Paddock, Troy N; Mason, Mary E; Lima, Daniel F; Armstrong, Gregory A

    2010-03-01

    In angiosperms the strictly light-dependent reduction of protochlorophyllide to chlorophyllide is catalyzed by NADPH:protochlorophyllide oxidoreductase (POR). The Arabidopsis thaliana genome encodes three structurally related but differentially regulated POR genes, PORA, PORB and PORC. PORA is expressed primarily early in development-during etiolation, germination and greening. In contrast, PORB and PORC are not only expressed during seedling development but also throughout the later life of the plant, during which they are responsible for bulk chlorophyll synthesis. The Arabidopsis porB-1 porC-1 mutant displays a severe xantha (highly chlorophyll-deficient) phenotype characterized by smaller prolamellar bodies in etioplasts and decreased thylakoid stacking in chloroplasts. Here we have demonstrated the ability of an ectopic PORA overexpression construct to restore prolamellar body formation in the porB-1 porC-1 double mutant background. In response to illumination, light-dependent chlorophyll production, thylakoid stacking and photomorphogenesis are also restored in PORA-overexpressing porB-1 porC-1 seedlings and adult plants. An Arabidopsis porB-1 porC-1 double mutant can therefore be functionally rescued by the addition of ectopically expressed PORA, which suffices in the absence of either PORB or PORC to direct bulk chlorophyll synthesis and normal plant development.

  3. Photoactive Protochlorophyllide-Enzyme Complexes Reconstituted with PORA, PORB and PORC Proteins of A. thaliana: Fluorescence and Catalytic Properties

    PubMed Central

    Gabruk, Michał; Stecka, Anna; Strzałka, Wojciech; Kruk, Jerzy; Strzałka, Kazimierz; Mysliwa-Kurdziel, Beata

    2015-01-01

    Photoactive Pchlide-POR-NADPH complexes were reconstituted using protochlorophyllide (Pchlide) and recombinant light-dependent protochlorophyllide oxidoreductase (POR) proteins, His₆-PORA, His₆-PORB and His₆-PORC, from Arabidopsis thaliana. We did not observe any differences in the kinetics of the protochlorophyllide photoreduction at room temperature among the PORA, PORB and PORC proteins. In contrast, the PORC protein showed lower yield of Chlide formation than PORA and PORB when preincubated in the dark for 30 min and then illuminated for a short time. The most significant observation was that reconstituted Pchlide-POR-NADPH complexes showed fluorescence maxima at 77 K similar to those observed for highly aggregated Pchlide-POR-NADPH complexes in prolamellar bodies (PLBs) in vivo. Homology models of PORA, PORB and PORC of Arabidopsis thaliana were developed to compare predicted structures of POR isoforms. There were only slight structural differences, mainly in the organisation of helices and loops, but not in the shape of whole molecules. This is the first comparative analysis of all POR isoforms functioning at different stages of A. thaliana development. PMID:25659137

  4. Patterns of change and continuity in ochre use during the late Middle Stone Age of the Horn of Africa: The Porc-Epic Cave record

    PubMed Central

    d’Errico, Francesco; Queffelec, Alain

    2017-01-01

    Ochre is found at numerous Middle Stone Age (MSA) sites and plays a key role in early modern human archaeology. Here we analyse the largest known East African MSA ochre assemblage, comprising 40 kg of ochre, found at Porc-Epic Cave, Ethiopia, spanning a period of at least 4,500 years. Visual characterisation of ochre types, microscopic identification of traces of modification, morphological and morphometric analysis of ochre pieces and modified areas, experimental reproduction of grinding processes, surface texture analysis of archaeological and experimentally ground ochre facets, laser granulometry of ochre powder produced experimentally on different grindstones and by Hamar and Ovahimba women from Ethiopia and Namibia respectively, were, for the first time, combined to explore diachronic shifts in ochre processing technology. Our results identify patterns of continuity in ochre acquisition, treatment and use reflecting both persistent use of the same geological resources and similar uses of iron-rich rocks by late MSA Porc-Epic inhabitants. Considering the large amount of ochre processed at the site, this continuity can be interpreted as the expression of a cohesive cultural adaptation, largely shared by all community members and consistently transmitted through time. A gradual shift in preferred processing techniques and motions is interpreted as reflecting cultural drift within this practice. Evidence for the grinding of ochre to produce small quantities of powder throughout the sequence is consistent with a use in symbolic activities for at least part of the ochre assemblage from Porc-Epic Cave. PMID:28542305

  5. Patterns of change and continuity in ochre use during the late Middle Stone Age of the Horn of Africa: The Porc-Epic Cave record.

    PubMed

    Rosso, Daniela Eugenia; d'Errico, Francesco; Queffelec, Alain

    2017-01-01

    Ochre is found at numerous Middle Stone Age (MSA) sites and plays a key role in early modern human archaeology. Here we analyse the largest known East African MSA ochre assemblage, comprising 40 kg of ochre, found at Porc-Epic Cave, Ethiopia, spanning a period of at least 4,500 years. Visual characterisation of ochre types, microscopic identification of traces of modification, morphological and morphometric analysis of ochre pieces and modified areas, experimental reproduction of grinding processes, surface texture analysis of archaeological and experimentally ground ochre facets, laser granulometry of ochre powder produced experimentally on different grindstones and by Hamar and Ovahimba women from Ethiopia and Namibia respectively, were, for the first time, combined to explore diachronic shifts in ochre processing technology. Our results identify patterns of continuity in ochre acquisition, treatment and use reflecting both persistent use of the same geological resources and similar uses of iron-rich rocks by late MSA Porc-Epic inhabitants. Considering the large amount of ochre processed at the site, this continuity can be interpreted as the expression of a cohesive cultural adaptation, largely shared by all community members and consistently transmitted through time. A gradual shift in preferred processing techniques and motions is interpreted as reflecting cultural drift within this practice. Evidence for the grinding of ochre to produce small quantities of powder throughout the sequence is consistent with a use in symbolic activities for at least part of the ochre assemblage from Porc-Epic Cave.

  6. Middle Stone Age Ochre Processing and Behavioural Complexity in the Horn of Africa: Evidence from Porc-Epic Cave, Dire Dawa, Ethiopia

    PubMed Central

    Rosso, Daniela Eugenia; Pitarch Martí, Africa; d’Errico, Francesco

    2016-01-01

    Ochre is a common feature at Middle Stone Age (MSA) sites and has often been interpreted as a proxy for the origin of modern behaviour. However, few ochre processing tools, ochre containers, and ochre-stained artefacts from MSA contexts have been studied in detail within a theoretical framework aimed at inferring the technical steps involved in the acquisition, production and use of these artefacts. Here we analyse 21 ochre processing tools, i.e. upper and lower grindstones, and two ochre-stained artefacts from the MSA layers of Porc-Epic Cave, Dire Dawa, Ethiopia, dated to ca. 40 cal kyr BP. These tools, and a large proportion of the 4213 ochre fragments found at the site, were concentrated in an area devoted to ochre processing. Lower grindstones are made of a variety of raw materials, some of which are not locally available. Traces of use indicate that different techniques were employed to process ochre. Optical microscopy, XRD, μ-Raman spectroscopy, and SEM-EDS analyses of residues preserved on worn areas of artefacts show that different types of ferruginous rocks were processed in order to produce ochre powder of different coarseness and shades. A round stone bearing no traces of having been used to process ochre is half covered with residues as if it had been dipped in a liquid ochered medium to paint the object or to use it as a stamp to apply pigment to a soft material. We argue that the ochre reduction sequences identified at Porc-Epic Cave reflect a high degree of behavioural complexity, and represent ochre use, which was probably devoted to a variety of functions. PMID:27806067

  7. Middle Stone Age Ochre Processing and Behavioural Complexity in the Horn of Africa: Evidence from Porc-Epic Cave, Dire Dawa, Ethiopia.

    PubMed

    Rosso, Daniela Eugenia; Pitarch Martí, Africa; d'Errico, Francesco

    2016-01-01

    Ochre is a common feature at Middle Stone Age (MSA) sites and has often been interpreted as a proxy for the origin of modern behaviour. However, few ochre processing tools, ochre containers, and ochre-stained artefacts from MSA contexts have been studied in detail within a theoretical framework aimed at inferring the technical steps involved in the acquisition, production and use of these artefacts. Here we analyse 21 ochre processing tools, i.e. upper and lower grindstones, and two ochre-stained artefacts from the MSA layers of Porc-Epic Cave, Dire Dawa, Ethiopia, dated to ca. 40 cal kyr BP. These tools, and a large proportion of the 4213 ochre fragments found at the site, were concentrated in an area devoted to ochre processing. Lower grindstones are made of a variety of raw materials, some of which are not locally available. Traces of use indicate that different techniques were employed to process ochre. Optical microscopy, XRD, μ-Raman spectroscopy, and SEM-EDS analyses of residues preserved on worn areas of artefacts show that different types of ferruginous rocks were processed in order to produce ochre powder of different coarseness and shades. A round stone bearing no traces of having been used to process ochre is half covered with residues as if it had been dipped in a liquid ochered medium to paint the object or to use it as a stamp to apply pigment to a soft material. We argue that the ochre reduction sequences identified at Porc-Epic Cave reflect a high degree of behavioural complexity, and represent ochre use, which was probably devoted to a variety of functions.

  8. Taxonomy: Sus bucculentus revisited.

    PubMed

    Robins, Judith H; Ross, Howard A; Allen, Melinda S; Matisoo-Smith, Elizabeth

    2006-04-13

    In 1997, the rediscovery of Sus bucculentus in Laos was announced by Groves et al.--this wild pig species had gone unrecorded since first being described in 1892. Although the identification of the new specimen was based initially on morphology, the authors also used a 7% sequence divergence from the common Eurasian pig S. scrofa (based on their analysis of 327 base pairs of the gene encoding mitochondrial 12S ribosomal RNA) as support for the species status of S. bucculentus. Concerned about the large divergence reported for a relatively conserved gene, and the absence of the sequence in any public database, we analysed an additional tissue sample from the specimen and found only 0.6% divergence from S. scrofa. Our more extensive analysis places the sample within the S. scrofa clade, calling into question the species status of S. bucculentus and demonstrating the need for both phylogenetic and morphological evidence in defining species.

  9. Click-chemistry approach to study mycoloylated proteins: Evidence for PorB and PorC porins mycoloylation in Corynebacterium glutamicum.

    PubMed

    Issa, Hanane; Huc-Claustre, Emilie; Reddad, Thamila; Bonadé Bottino, Nolwenn; Tropis, Maryelle; Houssin, Christine; Daffé, Mamadou; Bayan, Nicolas; Dautin, Nathalie

    2017-01-01

    Protein mycoloylation is a recently identified, new form of protein acylation. This post-translational modification consists in the covalent attachment of mycolic acids residues to serine. Mycolic acids are long chain, α-branched, β-hydroxylated fatty acids that are exclusively found in the cell envelope of Corynebacteriales, a bacterial order that includes important genera such as Mycobacterium, Nocardia or Corynebacterium. So far, only 3 mycoloylated proteins have been identified: PorA, PorH and ProtX from C. glutamicum. Whereas the identity and function of ProtX is unknown, PorH and PorA associate to form a membrane channel, the activity of which is dependent upon PorA mycoloylation. However, the exact role of mycoloylation and the generality of this phenomenon are still unknown. In particular, the identity of other mycoloylated proteins, if any, needs to be determined together with establishing whether such modification occurs in Corynebacteriales genera other than Corynebacterium. Here, we tested whether a metabolic labeling and click-chemistry approach could be used to detect mycoloylated proteins. Using a fatty acid alkyne analogue, we could indeed label PorA, PorH and ProtX and determine ProtX mycoloylation site. Importantly, we also show that two other porins from C. glutamicum, PorB and PorC are mycoloylated.

  10. Click-chemistry approach to study mycoloylated proteins: Evidence for PorB and PorC porins mycoloylation in Corynebacterium glutamicum

    PubMed Central

    Issa, Hanane; Huc-Claustre, Emilie; Reddad, Thamila; Bonadé Bottino, Nolwenn; Tropis, Maryelle; Houssin, Christine; Daffé, Mamadou; Bayan, Nicolas

    2017-01-01

    Protein mycoloylation is a recently identified, new form of protein acylation. This post-translational modification consists in the covalent attachment of mycolic acids residues to serine. Mycolic acids are long chain, α-branched, β-hydroxylated fatty acids that are exclusively found in the cell envelope of Corynebacteriales, a bacterial order that includes important genera such as Mycobacterium, Nocardia or Corynebacterium. So far, only 3 mycoloylated proteins have been identified: PorA, PorH and ProtX from C. glutamicum. Whereas the identity and function of ProtX is unknown, PorH and PorA associate to form a membrane channel, the activity of which is dependent upon PorA mycoloylation. However, the exact role of mycoloylation and the generality of this phenomenon are still unknown. In particular, the identity of other mycoloylated proteins, if any, needs to be determined together with establishing whether such modification occurs in Corynebacteriales genera other than Corynebacterium. Here, we tested whether a metabolic labeling and click-chemistry approach could be used to detect mycoloylated proteins. Using a fatty acid alkyne analogue, we could indeed label PorA, PorH and ProtX and determine ProtX mycoloylation site. Importantly, we also show that two other porins from C. glutamicum, PorB and PorC are mycoloylated. PMID:28199365

  11. SUS Source Level Error Analysis

    DTIC Science & Technology

    1978-01-20

    RIECIP1IEN’ CATALOG NUMBER * ITLE (and SubaltIe) S. TYP aof REPORT & _V9RCO SUS~ SOURCE LEVEL ERROR ANALYSIS & Fia 1.r,. -. pAURWORONTIUMm N (s)$S...Fourier Transform (FFTl) SUS Signal model ___ 10 TRA&C (CeEOINIMII1& ro"* *140O tidat n9#*#*Y a"d 0e~ntiff 6T 69*.4 apbt The report provides an analysis ...of major terms which contribute to signal analysis error in a proposed experiment to c-librate sourr - I levels of SUS (Signal Underwater Sound). A

  12. The complete mitochondrial genome of Sus cebifrons (Sus, Suidae).

    PubMed

    Liu, Fang; Tang, Hong-Xia; Liu, Yong-Gang; Bai, Ming-Jie; Tang, Yan-Xia

    2015-06-01

    In this work, we report the complete mitochondrial genome sequence of Sus cebifrons (Visayan warty pig). The total length of the mitogenome was 16,475 bp, and its overall base composition was estimated to be 35.0% for A, 25.8% for T, 26.2% for C and 13.0% for G, indicating an A-T (60.8%)-rich feature in Sus cebifrons mitogenome. It contained the typical structure of 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes and a noncoding control region (D-loop region). The arrangement of these genes was the same as that found in other pigs. The complete mitochondrial genome sequence of the Sus cebifrons would provide new genetic resources for pig domestication study.

  13. Le ciment brûle toujours

    PubMed Central

    Lebreton, T.; Fontaine, M.; Le Floch, R.

    2017-01-01

    Summary Les brûlures chimiques par ciment représentent une cause fréquente de corrosion cutanée en France. Elles nécessitent fréquemment un traitement chirurgical. Notre étude rétrospective concerne tous les patients admis pour une brûlure par ciment dans le service entre 2004 et 2016. Quarante-neuf patients âgés de 21 à 71 ans ont été pris en charge dans le centre des brûlés du Centre Hospitalier Saint Joseph Saint Luc à Lyon entre 2004 et 2016. La population concernée était majoritairement masculine, relativement jeune (44 ans en moyenne) et professionnellement active. Les brûlures survenaient principalement dans le cadre d’accidents domestiques (78%). Elles étaient profondes et atteignaient majoritairement les membres inférieurs, de façon bilatérale. La surface brûlée représentait 3% de la surface cutanée totale. Presque tous les patients (98%) ont nécessité une prise en charge chirurgicale pour excision et autogreffe de peau mince. Un seul patient a bénéficié d’une cicatrisation dirigée. Le délai moyen entre la brûlure et la chirurgie était de 13 jours et la durée moyenne d’hospitalisation de 8 jours. Sept patients ont nécessité une prise en charge en centre de rééducation à leur sortie du service. Cette étude confirme la sévérité des brûlures chimiques par ciment. Elle met également en avant l’impact que peut avoir ce type de brûlure en terme de retentissement socio-économique dans une population de patients majoritairement jeune et active. Elle insiste sur le fait que des mesures doivent être prises afin d’informer cette population rarement professionnelle sur les risques encourus lors du mésusage du ciment. La réglementation actuelle, classant le ciment comme irritant, ne prend pas en compte son caractère corrosif et devrait être amendée. PMID:28592929

  14. Le Figaro. Revised.

    ERIC Educational Resources Information Center

    Crawford, Linda

    These instructional materials are designed for students with some French reading skills and vocabulary in late beginning or early intermediate senior high school French. The objectives are to introduce students to a French newspaper, "Le Figaro," and develop reading skills for skimming, gathering specific information, and relying on cognates. The…

  15. Le Indeterminacy in Spanish.

    ERIC Educational Resources Information Center

    Foster, David William

    The standard treatment of object pronouns in Latin American Spanish assigns a direct-object function to "lo" and "la" and an indirect-object function to "le." This study challenges this descriptive attribution in light of the contradictory and refractory evidence in Spanish morphosyntax. It is suggested that more…

  16. Le mouvement du pôle

    NASA Astrophysics Data System (ADS)

    Bizouard, Christian

    2012-03-01

    Les variations de la rotation terrestre. En conditionnant à la fois notre vie quotidienne, notre perception du ciel, et bon nombre de phénomènes géophysiques comme la formation des cyclones, la rotation de la Terre se trouve au croisement de plusieurs disciplines. Si le phenomena se faisait uniformément, le sujet serait vite discuté, mais c'est parce que la rotation terrestre varie, même imperceptiblement pour nos sens, dans sa vitesse angulaire comme dans la direction de son axe, qu'elle suscite un grand intérêt. D'abord pour des raisons pratiques : non seulement les aléas de la rotation terrestre modi_ent à la longue les pointés astrométriques à un instant donné de la journée mais in_uencent aussi les mesures opérées par les techniques spatiales ; en consequence l'exploitation de ces mesures, par exemple pour déterminer les orbites des satellites impliqués ou pratiquer le positionnement au sol, nécessite une connaissance précise de ces variations. Plus fondamentalement, elles traduisent les propriétés globales de la Terre comme les processus physiques qui s'y déroulent, si bien qu'en analysant les causes des fluctuations observées, on dispose d'un moyen de mieux connaître notre globe. La découverte progressive des fluctuations de la rotation de la Terre a une longue histoire. Sous l'angle des techniques d'observation, trois époques se pro-celle du pointé astrométrique à l'oeil nu, à l'aide d'instruments en bois ou métalliques (quart de cercle muraux par exemple). À partir du XVIIe siècle débute l'astrométrie télescopique dont les pointés sont complétés par des datations de plus en plus précises grâce à l'invention d'horloges régulées par balancier. Cette deuxième époque se termine vers 1960, avec l'avènement des techniques spatiales : les pointés astrométriques sont délaissés au profit de la mesure ultra-précise de durées ou de fréquences de signaux électromagnétiques, grâce à l'invention des horloges

  17. Streptococcus pneumoniae, le transformiste.

    PubMed

    Johnston, Calum; Campo, Nathalie; Bergé, Matthieu J; Polard, Patrice; Claverys, Jean-Pierre

    2014-03-01

    Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Natural genetic transformation, which was discovered in this species, involves internalization of exogenous single-stranded DNA and its incorporation into the chromosome. It allows acquisition of pathogenicity islands and antibiotic resistance and promotes vaccine escape via capsule switching. This opinion article discusses how recent advances regarding several facets of pneumococcal transformation support the view that the process has evolved to maximize plasticity potential in this species, making the pneumococcus le transformiste of the bacterial kingdom and providing an advantage in the constant struggle between this pathogen and its host.

  18. Measuring AT Usability with the Modified System Usability Scale (SUS).

    PubMed

    Friesen, Emma L

    2017-01-01

    The modified System Usability Scale (SUS) is a widely used generic measure of product usability. This study concerns the usability of mobile shower commodes using correlations between the SUS and AT device-specific measures. Results suggest the modified SUS, and corresponding adjective-anchored rating scale, are appropriate for measuring MSC usability, and have potential for use with other AT devices.

  19. SQUARE DEAL Explosive Source (SUS) Propagation Measurements

    DTIC Science & Technology

    1976-07-19

    opposite. (C) One interesting feature of the SUS propagation loss measurements is that there usually is no strong convergence zone/ shadow zone...partially bounded on three sides by the mid-Atlantic Ridge (composed of the Reykjanes Ridge and the Faraday Seamount Group), the Rockall Bank, and the...Site 1B is at a depth of 2039 m., just above critical depth on a seamount along the mid-Atlantic Ridge. Event Th is a radial run at a bearing of 200

  20. NEP facilities (LeRC)

    NASA Technical Reports Server (NTRS)

    Vetrone, Robert H.

    1993-01-01

    The topics are presented in viewgraph form and include the following: the Electric Propulsion Research Building (no. 16) the Electric Power Laboratory (BLDG. 301); the Tank 6 Vacuum Facility; and test facilities for electric propulsion and LeRC.

  1. Le bégaiement

    PubMed Central

    Perez, Hector R.; Stoeckle, James H.

    2016-01-01

    Résumé Objectif Fournir une mise à jour sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental. Qualité des données Une recherche d’études récentes ou non portant sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental a été effectuée dans les bases de données MEDLINE et Cochrane. La plupart des recommandations s’appuient sur des études de petite envergure, des données probantes de qualité limitée ou des consensus. Message principal Le bégaiement est un trouble d’élocution fréquent chez les personnes de tous âges, il altère la fluidité verbale normale et l’enchaînement du discours. Le bégaiement a été lié à des différences de l’anatomie, du fonctionnement et de la régulation dopaminergique du cerveau qui seraient de source génétique. Il importe de poser le diagnostic avec attention et de faire les recommandations qui conviennent chez les enfants, car de plus en plus, le consensus veut que l’intervention précoce par un traitement d’orthophonie soit cruciale chez les enfants bègues. Chez les adultes, le bégaiement est lié à une morbidité psychosociale substantielle, dont l’anxiété sociale et une piètre qualité de vie. Les traitements pharmacologiques ont soulevé l’intérêt depuis quelques années, mais les données cliniques sont limitées. Le traitement des enfants et des adultes repose sur l’orthophonie. Conclusion De plus en plus de recherches ont tenté de lever le voile sur la physiopathologie du bégaiement. La meilleure solution pour les enfants et les adultes bègues demeure la recommandation à un traitement d’orthophonie.

  2. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne lele de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  3. Prendre le virage des partenariats.

    PubMed

    Sebestyen, Norma; Sulatycky, Ron; Rondos, Spyro; Davis, Sheila

    2015-11-01

    Deux projets démontrent que la mise en œuvre de données colligées sur le terrain peut contribuer à régler des problèmes dans le milieu de la santé pour favoriser de meilleurs résultats et de plus grandes efficiences. Dans le premier exemple, une vaste coalition de partenaires publics et privés de l'Alberta recourt aux techniques de mesures améliorées et à la méthodologie du Triple objectif pour améliorer les résultats cliniques de populations de cas complexes et lourds du quartier Eastwood d'Edmonton. On espère que les conclusions novatrices qui en sont tirées seront adaptées à d'autres régions de la province. Dans le deuxième exemple, la Childhood Obesity Foundation s'associe à Merck au Canada et à Ayogo (une société de thérapies numériques située à Vancouver) et utilise le concept novateur de la « ludification » pour mobiliser les jeunes de plus en plus sédentaires du Canada et modifier leurs comportements. © 2015 Collège canadien des leaders en santé

  4. Les hommes regardent le ciel.

    NASA Astrophysics Data System (ADS)

    Jaschek, C.

    Contents: 1. Le ciel nocturne. 2. Le mouvement du soleil. 3. La lune et ses mouvements. 4. L'orientation des bâtiments. 5. Les étoiles et les constellations. 6. Les planètes. 7. Les comètes, météores et météorites. 8. Les phénomènes météorologico-astronomiques. 9. Les éclipses. 10. Le temps et les calendriers. 11. Astres et destinée humaine - l'astrologie. 12. Les mythes de la création du monde. 13. Les mythes de la fin du monde. 14. Astronomie et société.

  5. Laser bendability of SUS430/C11000/SUS430 laminated composite and its constituent layers

    NASA Astrophysics Data System (ADS)

    Hossein Seyedkashi, S. M.; Gollo, Mohammad Hoseinpour; Biao, Jin; Moon, Young Hoon

    2016-05-01

    Laminated composites are of great interest in different industries while having the advantages of all base metals. In this research, the laser bending of a three-layered SUS430/C11000/SUS430 laminated composite is characterized both experimentally and numerically. This composite can be used in the microelectronics industry since it has the anti-corrosion and strength capability of stainless steel, and the electrical superiority of copper. The specimens are bent using a Ytterbium fiber laser irradiated on a straight path along the sheet width. The effects of bending parameters including the number of passes, scanning velocity, beam diameter, laser power and delay time between passes are examined for a three-layered laminated sheet, and compared with its constituent steel and copper layers. It is found that the thin copper mid-layer strongly affects the rate of bending per pass. Heat distribution and plastic strain along the thickness during the process are characterized by using the finite element method. The Cu mid-layer decreases the bending angle, but also postpones the onset of melting, and thus can be compensated by the application of higher laser powers. It is shown that the bending angle increases with an increase in laser power and delay time, and a decrease in laser velocity and beam diameter.

  6. Le verifiche della relatività generale

    NASA Astrophysics Data System (ADS)

    Tempesti, Piero

    2005-10-01

    La relatività di Einstein. La relatività generale messa alla prova. Le tre verifiche classiche: L'avanzamento del perielio di Mercurio - La deflessione della luce - Il redshift gravitazionale. Le verifiche di seconda generazione: Il rallentamento della luce - L'effetto Nordtvedt - Le onde gravitazionali e la "pulsar binaria".

  7. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-12-01

    XMM à la recherche de la matière exotique; Ancienne étoile; Le Trou noir volant; Magnétar; Stardust et Annefrank; Le centre de la galaxie; Deux trous noirs dans la même galaxie; Eruption géante sur Io; Le Soleil;

  8. Le LHC, un tunnel cosmique

    ScienceCinema

    None

    2016-07-12

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  9. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-09-01

    Fragmentation et astéroïdes binaires; Astéroïde géocroiseur triple; Rosetta sort de son hibernation; Messenger; Transit lunaire vu par Deep Impact; Titan; Phobos; Phoenix; Einstein avait raison; Le ballet des taches rouges; Le poids des lentilles;

  10. Le syndrome d'apert

    PubMed Central

    Benmiloud, Sarra; Chaouki, Sana; Atmani, Samir; Hida, Moustapha

    2013-01-01

    Le syndrome d'Apert est une affection congénitale rare, caractérisée par une sténose cranio-faciale associée à une syndactylie des mains et des pieds. Sa prise en charge doit être précoce et multidisciplinaire. Sa gravité réside dans la coexistence de plusieurs malformations avec un risque d'hypertension intracrânienne chronique responsable d'une cécité et d'une débilité mentale. Les auteurs rapportent une nouvelle observation à travers laquelle ils illustrent les aspects cliniques et évolutifs ainsi que les difficultés thérapeutiques de cette affection. PMID:23565313

  11. Intraday LeBaron effects

    PubMed Central

    Bianco, Simone; Corsi, Fulvio; Renò, Roberto

    2009-01-01

    We study the relation at intraday level between serial correlation and volatility of the Standard and Poor (S&P) 500 stock index futures returns. At daily and weekly levels, serial correlation and volatility forecasts have been found to be negatively correlated (LeBaron effect). After finding a significant attenuation of the original effect over time, we show that a similar but more pronounced effect holds by using intraday measures, by such as realized volatility and variance ratio. We also test the impact of unexpected volatility, defined as the part of volatility which cannot be forecasted, on the presence of intraday serial correlation in the time series by employing a model for realized volatility based on the heterogeneous market hypothesis. We find that intraday serial correlation is negatively correlated to volatility forecasts, whereas it is positively correlated to unexpected volatility.

  12. Le Point sur... Astronomie IV

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    Cet ouvrage regroupe des articles de mise au point sollicités par le rédacteur en chef de la rubrique Astronomie des Comptes rendus de l'Académie des sciences. Les textes se proposent de faire découvrir aux lecteurs, dans les principales disciplines de l'astronomie, les résultats les plus remarquables des dernières années.Leurs auteurs sont des spécialistes participant activement à l'accroissement des connaissances dans des domaines faisant l'objet de recherches intensives. Ces mises au point sur des questions particulièrement importantes de l'astronomie sont rédigées soit en français, soit en anglais et accompagnées d'une bibliographie détaillée.

  13. Bovine tuberculosis in a wild boar (Sus scrofa) in Poland.

    PubMed

    Krajewska, Monika; Lipiec, Marek; Zabost, Anna; Augustynowicz-Kopeć, Ewa; Szulowski, Krzysztof

    2014-10-01

    Poland is officially tuberculosis free and bovine tuberculosis (BTB) cases are rarely found except in bovids. We found BTB in a wild boar (Sus scrofa) in the Bieszczady Mountains, southeastern Poland. Studies suggest possible transmission of infection between free-living European bison (Bison bonasus caucasicus) and wild boar in this area.

  14. 2014 Higher Education Summit/SUS Data Workshop Proceedings

    ERIC Educational Resources Information Center

    Board of Governors, State University System of Florida, 2014

    2014-01-01

    Information Resource Management--State University System of Florida (IRM-SUS) is the primary collector and provider of data concerning state universities that is used to make sound education policy decisions. The office provides technical assistance to those using the information, state and federal reporting support, those supplying information,…

  15. Evolution of microstructure and mechanical properties of SUS430/C11000/SUS430 composites during the laser-forming process

    NASA Astrophysics Data System (ADS)

    Abazari, Hamed Delfan; Seyedkashi, Seyed Mohammad Hossein; Gollo, Mohammad Hoseinpour; Moon, Young Hoon

    2017-09-01

    Multilayered sheet metals have been widely used to achieve a wide range of favorable mechanical, physical, thermal and electrical properties. Laser beam irradiation over these materials creates extreme temperature changes that can lead to changes in the microstructural properties. Microstructure plays a very crucial role in determining the mechanical property of the irradiated region, thus determining the optimum laser processing conditions. In this study, metallographic studies, as well as tensile, fatigue and hardness tests, are undertaken on SUS430/C11000/SUS430 laminated composites that have been exposed to laser irradiation with different number of passes. This composite can be used in the microelectronics industry since it has the anti-corrosion and strength capability of stainless steel, and the electrical superiority of copper. Ytterbium fiber laser is used in such a way that the governing mechanism of the process is the temperature gradient mechanism. Evolution of the microstructure is revealed by metallography, and the fracture levels of tension and fatigue test specimens are further evaluated by SEM. This study illustrates the significant effects of successive laser irradiation on the evolution of microstructure and mechanical properties, which lead to some suggestions for improving the properties of laser-formed SUS430/C11000/SUS430 composites.

  16. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-12-01

    ISON; (3200) Phaéton; Titan, lacs et hydrocarbures; Titan et le Soleil; Jets; z8_GND_5296; La nébuleuse de la Crevette; Planète isolée; Nébuleuse Toby Jug; Le pulsar du Crabe; Le bulbe de la Voie lactée; ALMA au grand complet; APEX, ArTéMiS; Sgr A*; Première détection de l’acétate de méthyle dans l’espace

  17. Jan Potocki et le "Gothic Novel"

    ERIC Educational Resources Information Center

    Finne, Jacques

    1970-01-01

    Establishes a parallel between the supernatural and fantastic qualities of Le Comte Jan Potocki's literary works, and the English gothic novels by comparing the elements of terror, mysterious atmosphere, and the supernatural beings involved. (DS)

  18. Jan Potocki et le "Gothic Novel"

    ERIC Educational Resources Information Center

    Finne, Jacques

    1970-01-01

    Establishes a parallel between the supernatural and fantastic qualities of Le Comte Jan Potocki's literary works, and the English gothic novels by comparing the elements of terror, mysterious atmosphere, and the supernatural beings involved. (DS)

  19. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-06-01

    Deep Impact; Comète 73P/Schwassmann-Wachmann 3; L'anneau bleu d'Uranus; Triplet de neptunes; Triton; Dunes de Titan; Aréologie; Tache Rouge Junior; Obliquité des grosses planètes; Le jour de Saturne; Xéna; Un compagnon pour le Soleil; Galaxies satellites; Séisme sur une étoile à neutrons; Trou noir double; Hydrogène lointain

  20. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-02-01

    le errant; Pluton et Charon; Du côté d'Uranus !; Stardust; G29-38; La chasse aux planètes; Étoile polaire; Véga; Vers un interféromètre infrarouge à base kilométrique; Des pulsars extraordinaires; Trous noirs intermédiaires; Le trou noir central de la Galaxie; N44; Tornade spatiale

  1. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2005-03-01

    Trou noir glouton, Matière noire, Integral et le centre de notre Galaxie, Essaim de trous noirs, Carrousel autour de trous noirs, Érosion de trous noirs, Un quasar dans NGC 7319?, Distance de T Tauri, Chai non manquant, Des planètes autour d'une naine brune?, Titan, Une quatrième planète pour le pulsar PSR B1257+12, Smart 1, Aurores de Saturne

  2. La Vie Politique sous la Restauration a Travers ’Le Rouge et le Noir’ de Stendahl (The Political Life during the Restauration as Depicted in Le Rouge et le Noir by Stendahl)

    DTIC Science & Technology

    1989-01-01

    Valenod et Moirod, qul hissent le drapeau lib6ral uniquenient pour aznoIiorer leurs propres 20 conditions. Ils n’ont ni souci pour les paysans ni... propre benefice. Le lecteur est introduit a M. Valenod tres t~t dans le livre. 11 est le directeur du depot de mendicit6 A Verrlieres qui craint la visite... propres desse ins. Le groupe de vrais lib~t-aux stendhal lens comprend Fouqu6 qui est le bon ami de Julilen Sorel , le phi losophe Saint- Giraud. et

  3. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  4. Sequencing and cardiac expression of Apelin in Sus Scrofa.

    PubMed

    Del Ry, Silvia; Cabiati, Manuela; Raucci, Serena; Simioniuc, Anca; Caselli, Chiara; Prescimone, Tommaso; Giannessi, Daniela

    2009-10-01

    In humans, the Apelin gene is located on chromosome Xq25-26.1 and it encodes a 77-aminoacid prepropeptide. Considerable sequence homology exists across different mammalian species. Apelin is emerging as an important regulator of cardiovascular homeostasis but, at present, few data from humans are available and further studies are necessary to better define its role in cardiovascular pathophysiology. The role and function of Apelin in cardiovascular system could be reliably investigated in experimental models devoid of confounding effects reflecting only the natural history of the disease. The pig constitutes a model largely used in experimental pathology where it has a central role in "in vivo" clinical settings. Sus Scrofa genoma is not completely sequenced and Apelin gene is still lacking. Aim of this study was to sequence the Apelin in Sus Scrofa for future applications to molecular biology studies. Using the guanidinium thyocyanate-phenol-chloroform method, we extracted total RNA from samples obtained from heart of mouse and from atrium and ventricle of normal pigs. Pig Apelin mRNA was sequenced using polymerase chain reaction primers designed from mouse consensus sequences. A partial sequence of Sus Scrofa Apelin mRNA, 1-201 pb, was submitted to GenBank (accession number FJ362603). The bands obtained from pig cardiac tissue shared a 99% sequence identity with Mus musculus and 90% with Rattus norvegicus. The knowledge of Apelin sequence can be an useful starting point for future studies devoted to better understand the possible alterations of Apelin mRNA expression in different cardiac diseases.

  5. The financing of SUS in a scenario of financialization.

    PubMed

    Mendes, Aquilas; Marques, Rosa Maria

    2009-01-01

    This article rebuilds the process of the institutionalization process of the financing of Unified Health System (SUS), impaired, initially, by the macroeconomic policy conditions, developed during the decades of 1990 and 2000, and, ultimately, by the effects caused by the present phase of capitalism, concerning financial capital supremacy. It also identifies, within the political and economic framework, conflicts existing with the economic area of the federal government, highlighting the conditions imposed to financing and the concept of health, being universal and an essential component of Social Security.

  6. Intestinal protozoa in wild boars (Sus scrofa) in western Iran.

    PubMed

    Solaymani-Mohammadi, S; Rezaian, M; Hooshyar, H; Mowlavi, G R; Babaei, Z; Anwar, M A

    2004-10-01

    A total of 12 gastrointestinal tracts of wild boars (Sus scrofa) from western Iran (Luristan) were examined for protozoan infection between September 2000 and November 2001. Of 12 boars examined, 67% harbored one or more species of the following protozoa: Balantidium coli (25%), Tritrichomonas suis (25%), Blastocystis sp. (25%), Entamoeba polecki (17%), Entamoeba suis (8%), Iodamoeba butschlii (17%), and Chilomastix mesnili (8%). Four of these protozoan species also are reported in humans, and persons living in rural areas where wild boars are abundant should take precaution to avoid infection.

  7. Biomoleküle in Bewegung: Proteindynamik

    NASA Astrophysics Data System (ADS)

    Parak, Fritz G.

    2004-11-01

    Viele Proteinmoleküle sind kleine Maschinen. Im Stillstand ist ihr Aufbau wohlbekannt. Doch wie sie arbeiten, ist meistens unklar. Die Grundlagen dieser Proteindynamik werden am Beispiel des Sauerstoffspeicher-Proteins Myoglobin physikalisch untersucht. Dabei ist die Mößbauer-Spektroskopie am Hämeisen besonders hilfreich. Während sich das Myoglobin bei sehr tiefen Temperaturen in einem festkörperähnlichen Standby-Modus befindet, werden oberhalb einer charakteristischen Temperatur im Molekül proteinspezifische Bewegungsmoden aktiviert. Sie lassen sich als langsame, diffusionsartige Fluktuationen von Molekülsegmenten um die mittlere Struktur beschreiben. Diese Moden öffnen Kanäle in das Proteininnere, durch die Sauerstoffmoleküle zur Hämgruppe gelangen können. So ermöglichen sie Strukturänderungen, die für die biologische Funktion entscheidend sind.

  8. Les Brulures Chimiques Par Le Laurier Rose

    PubMed Central

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Summary Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose de gravité différente. Cela doit aboutir à une information élargie de la population, ainsi qu'une réglementation stricte de sa commercialisation. PMID:21991211

  9. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-09-01

    Jeunes étoiles et vieilles galaxies; Chiens de Chasse; Des images en partie belges; Détection chimique de planètes?; Amas cannibale; Le pulsar œil de bœuf; Supernova 2002 DJ; Centaurus A; Et de cent; Près du trou noir; Un cratère sous la Merdu Nord; Des astéroï des frôlent la Terre; Photons fatigués; Taches solaires; Un grand lac martien; Les naines brunes en infrarouge; Bourrelet équatorial; Fusion de trous noirs; Le hamburger de Gomez; Matière sombre; Non aux étoiles à quarks

  10. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2005-06-01

    Rosetta, Deep Impact, Titan Cratère sur Titan, Point chaud sur Titan, Phoebé, Treize nouvelles lunes pour Saturne, Épiméthée, Le mystère d'Amalthée, L'anomalie Pioneer, 2M1207, Oui, c'est une planète, Mini cratères martiens, On a retrouvé le Mars Polar Lander, Au Soleil toute l'année, Amplification cosmique, Hubble a quinze ans, Collision de vents dans WR 140, Création d'un trou noir, Un anneau d'Einstein presque parfait, Super flares, Mira en X

  11. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-06-01

    Future lune ? - L'âge de la Lune - Des volcans actifs sur Vénus - Un lac dans le cratère Gusev ? - Météorites et atmosphère martiennes - L’hexagone de Saturne - Pluton - Exo-Terre - Bêta Pictoris b - Cérès et Vesta depuis Mars - Naine froide - Parallaxes par Hubble - L2 Puppis et le sort du Soleil - Supernova et lentille gravitationnelle - Champ magnétique galactique - L’objet de Sakurai - Fermi et la matière noire - Lentille naine

  12. Le continu contre l'espace

    NASA Astrophysics Data System (ADS)

    Salanskis, Jean-Michel

    Disons pour conclure que, en tout état de cause, la façon de concevoir philosophiquement le conflit du continu et de l'espace que nous avons trouvée chez Hegel n'est pas homogène avec le style et les modalités de la pensée mathématique: 1) d'une part, le lien classique, le lien de référence entre continu et espace en mathématiques n'est pas que l'espace serait premier et privé de pensée, et le continu second, venant dissoudre l'espace en apportant la qualité, l'infini et la pensée, mais tout au contraire, il consiste en ce que l'espace est fondé sur l'abîme infinitaire du continu ; 2) d'autre part, l'éventuel divorce entre l'espace et le continu dans l'aire mathématique n'est pas celui d'une réflexivité purement conceptuelle du continu avec un positivisme géométrique, n'équivaut pas à une rupture disciplinaire ; il est plutôt le symptôme de la dérive d'une herméneutique à l'égard d'une autre, au sein d'un continent juridique commun définissant la discipline (la mathématique ensembliste), cette dérive pouvant, à la limite, induire une refonte de ce sol juridique, sans que jamais il soit question pour autant de nier l'unité des mathématiques, à comprendre ici comme l'unité ultime de responsabilité de la communauté mathématique à l'égard des trois questions Qu'est-ce que l'espace?”, “Qu'est-ce que le continu?” et “Qu'est-ce que l'infini?”.

  13. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-04-01

    Jets stellaires; Structure géante et matière noire; Un mini-système solaire; Arcs gravitationnels et images multiples; Choc frontal dans notre Galaxie; Avalanches martiennes; Du sable autour de KH 15D; Le cratère de Carancas; Smart-1;

  14. Le Chatelier's principle in replicator dynamics

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  15. Le Chatelier's principle in replicator dynamics.

    PubMed

    Allahverdyan, Armen E; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  16. Le Chatelier--Right or Wrong?

    ERIC Educational Resources Information Center

    Helfferich, Friedrich G.

    1985-01-01

    Presents a class exercise designed to find out how well students understand the nature and consequences of the mass action law and Le Chatelier's principle as applied to chemical equilibria. The exercise relates to a practical situation and provides simple relations for maximizing equilibrium quantities not found in standard textbooks. (JN)

  17. Microscopic Description of Le Chatelier's Principle

    ERIC Educational Resources Information Center

    Novak, Igor

    2005-01-01

    A simple approach that "demystifies" Le Chatelier's principle (LCP) and simulates students to think about fundamental physical background behind the well-known principles is presented. The approach uses microscopic descriptors of matter like energy levels and populations and does not require any assumption about the fixed amount of substance being…

  18. Le Chatelier's Principle, Temperature Effects, and Entropy.

    ERIC Educational Resources Information Center

    Campbell, J. Arthur

    1985-01-01

    One of the most useful methods of understanding chemical equilibria is provided by Le Chatelier's principle. The relationships between this principle, temperature, and entropy are discussed. Tables with thermodynamic data for some net reactions commonly used to illustrate the principle and for reactions involving gases are included. (JN)

  19. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs…

  20. A Compositional Analysis of "-GUO" and "-LE."

    ERIC Educational Resources Information Center

    Mangione, L.; Li, Dingxuan

    1993-01-01

    Paper examines interaction of semantic contributions of aspect markers "-guo" and "-le"; negative adverbs "bu" and "mei"; and two classes of verbs. Proposed analysis systematically accounts for temporal orientation of members of several classes of sentences in terms of aspectual contributions made by two aspect markers, negative adverbs, verbs,…

  1. Technical Programme 1993 (Le Programme Technique, 1993)

    DTIC Science & Technology

    1992-09-01

    Symposium sur "Les Effets de la Propagation Atmospherique a travers des Obscurcissants Naturels et Artificiels sur le Rayonnement des Ondes Millimetriques...for Small Gas Turbines" Reunion du Panel et Symposium sur "Les Technologies pour les Petites Turbines a Gaz " 4-8 CANADA TIP Panel Meeting/Specialists

  2. The Great Spanish "Le-Lo" Controversy

    ERIC Educational Resources Information Center

    Roldan, Mercedes

    1975-01-01

    The distinction between the clitics "le" and "lo" is different for Peninsular Spanish than for Latin American Spanish but is in both cases systematic. The division in Castilian Spanish is along the line of animate-inanimate. The Latin American division is between accusative and dative case. (TL)

  3. A Compositional Analysis of "-GUO" and "-LE."

    ERIC Educational Resources Information Center

    Mangione, L.; Li, Dingxuan

    1993-01-01

    Paper examines interaction of semantic contributions of aspect markers "-guo" and "-le"; negative adverbs "bu" and "mei"; and two classes of verbs. Proposed analysis systematically accounts for temporal orientation of members of several classes of sentences in terms of aspectual contributions made by two aspect markers, negative adverbs, verbs,…

  4. 30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE BASE COMPOUND, LOOKING EAST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  5. 29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE CLAIRE BASE COMPOUND, LOOKING WEST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  6. Serological anthrax surveillance in wild boar (Sus scrofa) in Ukraine.

    PubMed

    Bagamian, Karoun H; Skrypnyk, Artem; Rodina, Yana; Bezymennyi, Maksym; Nevolko, Oleg; Skrypnyk, Valeriy; Blackburn, Jason K

    2014-08-01

    Anthrax, caused by Bacillus anthracis, is an acute disease affecting wildlife, livestock, and humans worldwide, although its impact on these populations is underappreciated. In Ukraine, surveillance is passive, and anthrax is often detected in livestock. However, wildlife is not subject to surveillance, although anthrax deaths (such as in wild boar, Sus scrofa) have been documented. The wild boar is a plentiful and widespread species in Ukraine and is frequently hunted. We initiated a screening study testing Ukrainian wild boar blood samples for antibodies to B. anthracis. We mapped results relative to known livestock anthrax hotspots. We discovered evidence of exposure in wild boar up to 35 km from livestock anthrax hotspots and over 400 km from previous anthrax reports in boars. We make recommendations about using wildlife species as biosentinels for anthrax in Ukraine.

  7. Structural Classification of Wild Boar (Sus scrofa) Vocalizations.

    PubMed

    Garcia, Maxime; Gingras, Bruno; Bowling, Daniel L; Herbst, Christian T; Boeckle, Markus; Locatelli, Yann; Fitch, W Tecumseh

    2016-04-01

    Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig (Sus scrofa domesticus) vocalizations, for example, has led to significant advances in our understanding of communicative functions. Despite their close relation to domestic pigs, little is known about wild boar (Sus scrofa) vocalizations. The few existing studies, conducted in the 1970s, relied on visual inspections of spectrograms to quantify acoustic parameters and lacked statistical analysis. Here, we use objective signal processing techniques and advanced statistical approaches to classify 616 calls recorded from semi-free ranging animals. Based on four spectral and temporal acoustic parameters-quartile Q25, duration, spectral flux, and spectral flatness-extracted from a multivariate analysis, we refine and extend the conclusions drawn from previous work and present a statistically validated classification of the wild boar vocal repertoire into four call types: grunts, grunt-squeals, squeals, and trumpets. While the majority of calls could be sorted into these categories using objective criteria, we also found evidence supporting a graded interpretation of some wild boar vocalizations as acoustically continuous, with the extremes representing discrete call types. The use of objective criteria based on modern techniques and statistics in respect to acoustic continuity advances our understanding of vocal variation. Integrating our findings with recent studies on domestic pig vocal behavior and emotions, we emphasize the importance of grunt-squeals for acoustic approaches to animal welfare and underline the need of further research investigating the role of domestication on animal vocal communication.

  8. Exome Capture with Heterologous Enrichment in Pig (Sus scrofa).

    PubMed

    Guiatti, Denis; Pomari, Elena; Radovic, Slobodanka; Spadotto, Alessandro; Stefanon, Bruno

    2015-01-01

    The discovery of new protein-coding DNA variants related to carcass traits is very important for the Italian pig industry, which requires heavy pigs with higher thickness of subcutaneous fat for Protected Designation of Origin (PDO) productions. Exome capture techniques offer the opportunity to focus on the regions of DNA potentially related to the gene and protein expression. In this research a human commercial target enrichment kit was used to evaluate its performances for pig exome capture and for the identification of DNA variants suitable for comparative analysis. Two pools of 30 pigs each, crosses of Italian Duroc X Large White (DU) and Commercial hybrid X Large White (HY), were used and NGS libraries were prepared with the SureSelectXT Target Enrichment System for Illumina Paired-End Sequencing Library (Agilent). A total of 140.2 M and 162.5 M of raw reads were generated for DU and HY, respectively. Average coverage of all the exonic regions for Sus scrofa (ENSEMBL Sus_scrofa.Sscrofa10.2.73.gtf) was 89.33X for DU and 97.56X for HY; and 35% of aligned bases uniquely mapped to off-target regions. Comparison of sequencing data with the Sscrofa10.2 reference genome, after applying hard filtering criteria, revealed a total of 232,530 single nucleotide variants (SNVs) of which 20.6% mapped in exonic regions and 49.5% within intronic regions. The comparison of allele frequencies of 213 randomly selected SNVs from exome sequencing and the same SNVs analyzed with a Sequenom MassARRAY® system confirms that this "human-on-pig" approach offers new potentiality for the identification of DNA variants in protein-coding genes.

  9. How to simplify the CT diagnosis of Le Fort fractures.

    PubMed

    Rhea, James T; Novelline, Robert A

    2005-05-01

    The numerous components seen in the Le Fort fractures make classification difficult. Our objective is to simplify the task of classifying Le Fort fractures. Each of the Le Fort fractures has at least one unique component that is easily recognizable: I, the anterolateral margin of the nasal fossa; II, the inferior orbital rim; and III, the zygomatic arch. Classification of the Le Fort fractures is simplified by using these unique components to establish a tentative classification that is then confirmed.

  10. Alloimmunisation fœto-maternelle Rhésus grave à propos d'un cas et revue de la littérature

    PubMed Central

    Zineb, Benkerroum; Boutaina, Lachiri; Ikram, Lazrak; Driss, Moussaoui Rahali; Mohammed, Dehayni

    2015-01-01

    L'incompatibilité fœto-maternelle Rhésus peut être à l'origine d'un syndrome hémolytique dont l'expression clinique est l′anémie fœtale éventuellement compliquée par une anasarque fœto-placentaire ou à l'extrême une mort fœtale in utéro. Nous rapportons l'observation d'un cas d'allo immunisation Rhésus à 34 SA ayant aboutit un hydrops foetalis, l'extraction fœtale par césarienne en vue d'une exsanguino-transfusion a été réalisée, mais le nouveau né est décédé au cours de l'exsanguino-transfusion. Le dépistage des femmes à risque et l'utilisation d'Immunoglobulines anti D ont permis une réduction importante de l′incidence des accidents d'incompatibilité. La mesure du pic systolique de vélocité dans l'artère cérébrale moyenne a bouleversé la surveillance et la prise en charge prénatale des anémies fœtales secondaires à une allo-immunisation Rhésus. Son utilisation dans la surveillance des cas d'allo-immunisation Rhésus permettrait ainsi de réserver les procédures invasives (cordocentèse) comme geste thérapeutique qui permet la transfusion fœtale in utéro. Grâce à une collaboration multidisciplinaire cohérente, l'extraction fœtale peut être programmée, ce qui permet une prise en charge adéquate et rigoureuse, même des nouveaux nés avec atteinte sévère. PMID:26889318

  11. Le syndrome d’alcoolisme foetal

    PubMed Central

    2002-01-01

    L’alcool est un tératogène physique et comportemental. Le syndrome d’alcoolisme foetal (SAF) est un trouble courant mais encore sous-diagnostiqué découlant de la consommation d’alcool par la mère pendant la grossesse. Bien qu’il puisse être prévenu, le SAF est également invalidant. Même si le SAF est présent dans tous les groupes socioéconomiques du Canada, sa prévalence est élevée dans certaines communautés inuites et des Premières nations du Canada. Le présent énoncé porte sur la prévention, le diagnostic, le dépistage précoce et la prise en charge du SAF par les professionnels de la santé. La prévention du SAF doit s’effectuer à deux échelons. La prévention primaire consiste à éliminer le SAF par une formation en classe ou dans la collectivité et à inciter les femmes à éviter de consommer de l’alcool avant la conception et pendant la grossesse. La prévention secondaire consiste à repérer les femmes qui boivent pendant leur grossesse et à réduire leur consommation. Le présent énoncé décrit plusieurs stratégies de dépistage, dont la stratégie T-ACE (tolérance-agacement, réduction, éveil). Les dispensateurs de soins devraient recommander l’abstinence dès la première visite prénatale. Un envoi rapide en consultation en vue de traiter l’alcoolisme est recommandé pour les femmes enceintes incapables d’arrêter de boire. Le présent énoncé décrit le diagnostic de SAF, de SAF partiel ou atypique, d’anomalies congénitales et de troubles neurodéveloppementaux reliés à l’alcool. En cas d’exposition à l’alcool in utero, un diagnostic de SAF devrait être envisagé en présence d’un retard de croissance courant ou antérieur, de certaines anomalies faciales touchant la lèvre supérieure et les yeux et d’anomalies neurodéveloppementales. Ces caractéristiques sont mieux quantifiées au moyen d’une méthode diagnostique à quatre chiffres. Des stratégies de dépistage précoce des

  12. Polarization-controlled optical ring cavity (PORC) tunable pulse stretcher

    NASA Astrophysics Data System (ADS)

    Williamson, Andrew P.; Kiefer, Johannes

    2016-08-01

    A new concept and a theoretical approach for modeling a tunable polarization-controlled optical ring cavity pulse stretcher is demonstrated. The technique discussed herein permits highly simplified and flexible tuning of the temporal shape of nanosecond duration pulses. Using half-wave plates positioned extra- and intracavity, transmission to reflection ratios across both input faces of a polarization beam splitter can easily be controlled. The resulting models indicate a further reduction in peak intensity of 30%, with respect to conventional dielectric beam splitting optical ring cavities, when configured under equivalent and optimized cavity settings.

  13. An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1

    PubMed Central

    AbuQattam, Ali; Gallego, José; Rodríguez-Navarro, Susana

    2016-01-01

    Sus1 is a conserved protein involved in chromatin remodeling and mRNA biogenesis. Unlike most yeast genes, the SUS1 pre-mRNA of Saccharomyces cerevisiae contains two introns and is alternatively spliced, retaining one or both introns in response to changes in environmental conditions. SUS1 splicing may allow the cell to control Sus1 expression, but the mechanisms that regulate this process remain unknown. Using in silico analyses together with NMR spectroscopy, gel electrophoresis, and UV thermal denaturation experiments, we show that the downstream intron (I2) of SUS1 forms a weakly stable, 37-nucleotide stem–loop structure containing the branch site near its apical loop and the 3′ splice site after the stem terminus. A cellular assay revealed that two of four mutants containing altered I2 structures had significantly impaired SUS1 expression. Semiquantitative RT-PCR experiments indicated that all mutants accumulated unspliced SUS1 pre-mRNA and/or induced distorted levels of fully spliced mRNA relative to wild type. Concomitantly, Sus1 cellular functions in histone H2B deubiquitination and mRNA export were affected in I2 hairpin mutants that inhibited splicing. This work demonstrates that I2 structure is relevant for SUS1 expression, and that this effect is likely exerted through modulation of splicing. PMID:26546116

  14. An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1.

    PubMed

    AbuQattam, Ali; Gallego, José; Rodríguez-Navarro, Susana

    2016-01-01

    Sus1 is a conserved protein involved in chromatin remodeling and mRNA biogenesis. Unlike most yeast genes, the SUS1 pre-mRNA of Saccharomyces cerevisiae contains two introns and is alternatively spliced, retaining one or both introns in response to changes in environmental conditions. SUS1 splicing may allow the cell to control Sus1 expression, but the mechanisms that regulate this process remain unknown. Using in silico analyses together with NMR spectroscopy, gel electrophoresis, and UV thermal denaturation experiments, we show that the downstream intron (I2) of SUS1 forms a weakly stable, 37-nucleotide stem-loop structure containing the branch site near its apical loop and the 3' splice site after the stem terminus. A cellular assay revealed that two of four mutants containing altered I2 structures had significantly impaired SUS1 expression. Semiquantitative RT-PCR experiments indicated that all mutants accumulated unspliced SUS1 pre-mRNA and/or induced distorted levels of fully spliced mRNA relative to wild type. Concomitantly, Sus1 cellular functions in histone H2B deubiquitination and mRNA export were affected in I2 hairpin mutants that inhibited splicing. This work demonstrates that I2 structure is relevant for SUS1 expression, and that this effect is likely exerted through modulation of splicing.

  15. Le matérialisme scientifique

    NASA Astrophysics Data System (ADS)

    Meunier, Jean-François

    2004-03-01

    De nos jours, il arrive quotidiennement aux grands hommes d'avoir à fréquenter d'ignorants mortels épris d'une conviction maladive que la science est la grande responsable de tous les maux du monde. Évidemment sans physique atomique, il n'y aurait pas eu d'Hiroshima et sans révolution industrielle, pas de pollution et etc. Cependant, ces accusations envers le progrès technique sont tout à fait injustes, irréfléchies et, j'irai même jusqu'à dire, irresponsables, puisque le calcul, i.e. la planification, même la plus élémentaire, est ce qui caractérise le mieux, pragmatiquement, la société humaine. À mon avis, les problèmes sociaux tireraient plutôt leur origine de sciences sociales irréalistes, qui, concrètment, inspireraient ou serviraient d'alibis à ceux qui détiennent véritablement le pouvoir. Dans cet article, je tenterai donc de démontrer la meilleure véracité et efficacité du matérialisme scientifique. Cette doctrine, dont Mario Bunge est le plus illustre représentant, s'appuy sur les résultats théoriques et expérimentaux des sciences factuelles ainsi que sur l'exactitude logique des mathématiques, utilisées ici comme langage universel de l'expression des idées. Cette conception philosophique qui s'inspire principalement du modèle des théories physiques, stipule que les réalités sociales sont, comme tout autre réalité, matérielles, mathématisables et représentables comme des systèmes en interaction. En fait, le modèle des physiciens ayant historiquement fait ses preuves en matière de testabilité et de cohérence interne est proposé d'être appliquer aux sciences sociales, aujourd'hui scindées des sciences dites pures sous l'inspiration des pseudo penseurs néo-kantiens, phénoménologiques et post-moderne. Cette nouvelle approche permettrait ainsi d'évoluer plus exactement vers une compréhension des bases sociales et biologiques du comportement humain afin de développer une éthique sans cesse plus r

  16. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2003-09-01

    Système solaire poussiéreux; Combien d'étoiles dans le ciel?; Distance d'un pulsar; Planètes poussières et métaux; Un amateur belge bat les professionnels; Matière sombre; Supernova asymétrique; Anneau liégeois; Amas globulaires; Amas globulaires vagabonds; Baptême de satellites; Champ de gravité terrestre; Début de l'univers; XMM et Geminga; Carte neutrinos du ciel; Galaxies et trous noirs; Univers X; SMART-1: signal de départ pour l'aventure lunaire; Les saisons de Pluton; Planète dans M4; Rotation des pulsars; Un jumeau de Jupiter?; Le satellite ISO; Mars Express~:dernier clin d'oeil à la Terre; Waterworld: une réalité?

  17. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-06-01

    Une binaire remarquable; Collision de galaxies; La nébuleuse planétaire C1295; ALMA (suite); Couple massif; Astéroïdes lointains; L’eau de Jupiter; Occultation par Pluton; Super-Terres; Première image d’une planète massive autour d’une étoile double; Tempête au pôle de Saturne

  18. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-06-01

    Loi tchèque sur la pollution lumineuse; XTE J0929-314; Futurs amas de galaxies; Palomar 5; La météo des naines brunes; Trous noirs et galaxies elliptiques; Europe; 2MASS; Mars; Io; Matière sombre; Un objet très froid; Les oscillations stellaires; Un système lanétaire en formation; Binaire serrée; Satellites de Jupiter; Mars sous la loupe; Le Hubble nouveau

  19. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2003-01-01

    Premier plongeon d'Integral dans l'univers du rayonnement gamma; Collisions et cannibalisme galactique; Proplydes dans la Carène; Quasar record; Eta Carinae étoile double; Géantes rouges; La vitesse de la gravité; Sursaut gamma; Une planète lointaine; Un Troyen neptunien; L'univers lointain; Bébé galaxie; Le centre de notre Galaxie version X; Un HERO astronomique; Disque X géant; Electrons mystérieux dans RCW 38; Environnement martien; Interférométrie infrarouge; Méthane titanien; Micro-organismes atmosphériques; Réchauffement planétaire; La meilleure observation infrarouge de l'univers; Planètes en grand nombre?; Pôle sud et Big Bang; SS 433; Volcans et astéroïdes; Amalthée; De l'eau sur Mars; DEM L 106; Gliese 876; La taille des étoiles; Le danger des supernovas; Vieux cailloux

  20. Les Troubles Respiratoires Chez Le Brule

    PubMed Central

    Fassi Fihri, J.; Ezzoubi, M.; Boukind, E.H.

    2010-01-01

    Summary A travers une revue de la littérature, cet article se propose d'exposer les particularités des troubles respiratoires chez le brûlé. Ces troubles sont liés à un mécanisme direct, lorsque l'arbre respiratoire est lésé par le transfert d'énergie thermique du à la brûlure et/ou par un mécanisme indirect, lorsque la fonction respiratoire et ventilatoire du poumon est perturbée par les phénomènes loco-régionaux ou généraux du brûlé. Ces troubles respiratoires sont aggravés par l'inhalation des gaz contenus dans la fumée d'incendie. Le diagnostic de ces troubles est clinique et paraclinique. Il doit être précoce et continu. Les patients nécessitent de différents moyens thérapeutiques tels que l'oxygénothérapie, la libération des voies respiratoires, l'amélioration de la mécanique ventilatoire et de la fonction respiratoire, l'antibiothérapie ou la chirurgie des séquelles. Cette prise en charge doit nécessairement être multidisciplinaire. PMID:21991224

  1. Serosurvey of leptospirosis in feral hogs (Sus scrofa) in Florida.

    PubMed

    Chatfield, Jenifer; Milleson, Michael; Stoddard, Robyn; Bui, Duy M; Galloway, Renee

    2013-06-01

    Leptospira is a global pathogen of emerging public health importance in both developing and industrialized nations and can infect almost all mammalian species, including humans. As suburbanization and the popularity of outdoor recreational activities increases, so do human-wildlife and companion animal-wildlife interfaces. Florida offers a tropical climate favorable for outdoor activities and a semirural landscape that sustains an abundant feral hog population. Because no survey ofleptospirosis in feral hogs (Sus scrofa) in Florida has been published to our knowledge, we sought to establish preliminary seroprevalence ofleptospirosis exposure in feral hogs in Florida. Blood samples were collected opportunistically from 158 male and 166 female feral hogs taken at managed hunts and by permitted trappers in the northern, central, and southern regions of Florida. Samples were then analyzed using the microscopic agglutination test (MAT) for antibody titers to 20 Leptospira serovars representing 17 serogroups. A titer of > 1:100 was considered positive; 33% (107/324 total samples) were positive to at least one serovar, and 46% of those were positive to multiple serovars. Antibodies to L. interrogans serovar Bratislava strain Jez Bratislava (serogroup Australis) was the most common, with 18% (58/324) testing positive for antibodies. These initial data indicate that there is a significant possibility of feral hogs having a larger role in the complex etiology of leptospirosis in Florida than historically estimated and that further investigation is warranted.

  2. Results of fracture mechanics tests on PNC SUS 304 plate

    SciTech Connect

    Mills, W.J.; James, L.A.; Blackburn, L.D.

    1985-08-01

    PNC provided SUS 304 plate to be irradiated in FFTF at about 400/sup 0/C to a target fluence of 5 x 10/sup 21/ n/cm/sup 2/ (E > 0.1 MeV). The actual irradiation included two basically different exposure levels to assure that information would be available for the exposure of interest. After irradiation, tensile properties, fatigue-crack growth rates and J-integral fracture toughness response were determined. These same properties were also measured for the unirradiated material so radiation damage effects could be characterized. This report presents the results of this program. It is expected that these results would be applicable for detailed fracture analysis of reactor components. Recent advances in elastic-plastic fracture mechanics enable reasonably accurate predictions of failure conditions for flawed stainless steel components. Extensive research has focused on the development of J-integral-based engineering approach for assessing the load carrying capacity of low-strength, high-toughness structural materials. Furthermore, Kanninen, et al., have demonstrated that J-integral concepts can accurately predict the fracture response for full-scale cracked structures manufactured from Type 304 stainless steel.

  3. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research.

    PubMed

    Kornum, Birgitte R; Knudsen, Gitte M

    2011-01-01

    Within neuroscience and biobehavioral research, the pig (Sus scrofus) is increasingly being acknowledged as a valuable large animal species. Compared to the rodent brain, the pig brain more closely resembles the human brain in terms of both anatomy and biochemistry, which associates the pig with a higher translational value. Several brain disorders have been fully or partially modeled in the pig and this has further spurred an interest in having access to behavioral tasks for pigs, and in particular to cognitive tasks. Cognitive testing of pigs has been conducted for several years by a small group of farm animal welfare researchers, but it has only recently received interest in the wider neuroscience community. Several behavioral tasks have successfully been adapted to the pig, and valuable results have been produced. However, most tasks have only been established at a single research facility, and would benefit from further validation. This review presents the cognitive tasks that have been developed for pigs, their validation, and their current use.

  4. Comparative Testing of Hemostatic Dressing in a Large Animal Model (Sus Scorofa) with Severe hepatic Injuries

    DTIC Science & Technology

    2013-12-02

    hemostatic dressings in a large animal model (Sus scrofa ) with severe hepatic injuries PRINCIPAL INVESTIGATOR (PI) / TRAINING COORDINATOR (TC): Capt...to Date Sus scrofa 36 18 18 Note. Many fewer animals than approved were used because one of the original treatment groups (Lypressin- soaked gauze

  5. Advanced Laparoscopy Training for General Surgery Residents Using a Pig Model (Sus scrofa domestica)

    DTIC Science & Technology

    2010-01-01

    Surgery Residents Using a Pig Model ( Sus scrofa domestica) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Robert...Protocol Title: "Advanced Laparoscopy Training for General Surgery Residents Using a Pig Model ( Sus scrofa domestica)" 3. Principal Investigator (PI

  6. Resident Training in General Surgery Using a Pig Model (Sus scrofa domestica)

    DTIC Science & Technology

    2010-01-01

    Using a Pig Model ( Sus scrofa domestica) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Robert Cromer 5d. PROJECT...Training in General Surgery Using a Pig Model ( Sus scrofa domestica)" 3. Principal Investigator (PI): Maj Robert Cromer, USAF, MC, Staff General Surgeon, 81

  7. ViSUS: Visualization Streams for Ultimate Scalability

    SciTech Connect

    Pascucci, V

    2005-02-14

    In this project we developed a suite of progressive visualization algorithms and a data-streaming infrastructure that enable interactive exploration of scientific datasets of unprecedented size. The methodology aims to globally optimize the data flow in a pipeline of processing modules. Each module reads a multi-resolution representation of the input while producing a multi-resolution representation of the output. The use of multi-resolution representations provides the necessary flexibility to trade speed for accuracy in the visualization process. Maximum coherency and minimum delay in the data-flow is achieved by extensive use of progressive algorithms that continuously map local geometric updates of the input stream into immediate updates of the output stream. We implemented a prototype software infrastructure that demonstrated the flexibility and scalability of this approach by allowing large data visualization on single desktop computers, on PC clusters, and on heterogeneous computing resources distributed over a wide area network. When processing terabytes of scientific data, we have achieved an effective increase in visualization performance of several orders of magnitude in two major settings: (i) interactive visualization on desktop workstations of large datasets that cannot be stored locally; (ii) real-time monitoring of a large scientific simulation with negligible impact on the computing resources available. The ViSUS streaming infrastructure enabled the real-time execution and visualization of the two LLNL simulation codes (Miranda and Raptor) run at Supercomputing 2004 on Blue Gene/L at its presentation as the fastest supercomputer in the world. In addition to SC04, we have run live demonstrations at the IEEE VIS conference and at invited talks at the DOE MICS office, DOE computer graphics forum, UC Riverside, and the University of Maryland. In all cases we have shown the capability to stream and visualize interactively data stored remotely at the San

  8. Le déficit immunitaire humoral: mieux le connaître pour mieux le prendre en charge

    PubMed Central

    El Bakkouri, Jalila; Aadam, Zahra; Ailal, Fatima; Alj, Hanane Salih; Bousfiha, Ahmed Aziz

    2014-01-01

    Les déficits immunitaires humoraux (DIH) sont des maladies hétérogènes allant des formes asymptomatiques rencontrés lors des déficits sélectifs en immunoglobulines A (IgA) et en sous-classes d'IgG aux formes graves des agammaglobulinémies congénitales. Les patients atteints de DIH présentent souvent des infections ORL ou des voies respiratoires récidivantes ou sévères. Ces patients peuvent présenter un certain nombre de complications non infectieuses, telles que des manifestations auto-immunes et des entéropathies, qui pourraient être le seul symptôme clinique révélateur. Les formes sévères des DIH sont facilement diagnostiquées grâce au dosage des IgG totaux, des IgA et des IgM. La thérapie substitutive par les immunoglobulines reste le traitement de choix chez ces patients. PMID:25489366

  9. Le Chatelier's principle with multiple relaxation channels

    NASA Astrophysics Data System (ADS)

    Gilmore, R.; Levine, R. D.

    1986-05-01

    Le Chatelier's principle is discussed within the constrained variational approach to thermodynamics. The formulation is general enough to encompass systems not in thermal (or chemical) equilibrium. Particular attention is given to systems with multiple constraints which can be relaxed. The moderation of the initial perturbation increases as additional constraints are removed. This result is studied in particular when the (coupled) relaxation channels have widely different time scales. A series of inequalities is derived which describes the successive moderation as each successive relaxation channel opens up. These inequalities are interpreted within the metric-geometry representation of thermodynamics.

  10. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-04-01

    Cartographie d’une naine brune; 2006DP14; Anatomie d’un astéroïde; L’astéroïde P/2013 R3; Formation des planètes; Planètes Kepler; Bêta Pictoris; Cratère Mojave; Les astéroïdes de la ceinture principale; Planète X; Mercure et la gravitation; Gloire sur Vénus; Galaxies elliptiques massives; Cas A; SN 2014J et les supernovae Ia; Le Grand Nuage de Magellan; Nébuleuse d’Andromède; ESO 137-001

  11. Books reconsidered: Emile Durkheim, Le Suicide.

    PubMed

    Robertson, Michael

    2006-12-01

    To reappraise Emile Durkheim's taxonomy of suicide in Le Suicide in the light of recent experience. While Durkheim's scientific method and argument are fundamentally flawed, some of his concepts have instrumental value in attempting to understand the complex origins of suicidal behaviour. Durkheim's baseless dismissal of mental illness as a key determinant of suicidal behaviour weakens his thesis significantly. However, his conceptualization of anomic, egoistic and altruistic suicide provides a means of comprehending recent trends in suicidal behaviour in the former Soviet states and a possible window into the psyche of the suicides of religious and political extremists.

  12. Le synovialosarcome primitif de la verge

    PubMed Central

    Saadi, Ahmed; Bouzouita, Abderrazak; Kerkeni, Walid; Ayed, Haroun; Znaidi, Nadia Sabbegh; Ben Miled, Aicha; Messai, Taha; Cherif, Mohamed; Ben Slama, Riadh; Rammeh, Soumaya; Mnif, Najla; Maalej, Mongi; Derouiche, Amine; Chebil, Mohamed

    2017-01-01

    Résumé Le synovialosarcome représente un sous-type rare des sarcomes des tissus mous. Son apparition au niveau de la verge est exceptionnelle et seulement deux cas ont été rapportés dans la littérature auparavant. Nous rapportons un nouveau cas de synovialosarcome de la verge chez un jeune patient de 27 ans, en essayant par l’entremise d’une revue de la littérature de discuter des aspects radiologiques, histologiques, immunohistochimiques, thérapeutiques et pronostiques de cette tumeur exceptionnelle. PMID:28163814

  13. Lele de l’omalizumab dans le traitement de l’asthme allergique grave

    PubMed Central

    Chapman, Kenneth R; Cartier, André; Hébert, Jacques; McIvor, R Andrew; Schellenberg, R Robert

    2006-01-01

    CONTEXTE : Un nouveau traitement anti-immunoglobuline E (anti-IgE) contre l’asthme, l’omalizumab, a été approuvé au Canada. OBJECTIF : Passer en revue les données fondamentales et cliniques sur l’omalizumab et examiner lele possible de ce médicament dans la prise en charge de l’asthme au Canada. MÉTHODOLOGIE : Une recherche documentaire a été effectuée dans MEDLINE afin de repérer les études menées de 1960 à 2006 sur l’omalizumab. La recherche a également porté sur les résumés de réunions scientifiques récentes dans le domaine des maladies respiratoires et des allergies; par ailleurs, toute donnée non publiée a été demandée au fabricant. Après avoir revu et résumé les données, un comité mixte constitué de spécialistes des maladies respiratoires et des allergies a rédigé un ensemble de recommandations relatives à l’utilisation de l’omalizumab. RÉSULTATS : L’omalizumab est un anticorps monoclonal humanisé qui se lie au domaine C epsilon 3 de la molécule d’IgE pour former des complexes immuns solubles qui sont éliminés par le système réticulo-endothélial. L’administration d’injections sous-cutanées espacées de deux ou de quatre semaines à la dose recommandée entraîne une diminution rapide des taux d’IgE circulantes libres. Lors de deux essais cliniques de phase III menés auprès de 1 405 adultes et adolescents atteints d’asthme modéré à grave qui recevaient des doses moyennes stables de corticostéroïdes en inhalation (CSI), l’omalizumab a diminué les taux d’exacerbation par rapport au placebo et a été associé à une amélioration des symptômes ainsi qu’à une épargne plus importante des corticostéroïdes. Dans un essai mené auprès de 419 patients atteints d’asthme grave non maîtrisé malgré l’utilisation de doses élevées de CSI et de la prise concomitante d’agonistes bêta-2 à action prolongée, les exacerbations graves étaient de 50 % moins fréquentes chez

  14. [Analysis of the progressivity of Brazilian Unified National Health System (SUS) financing].

    PubMed

    Ugá, Maria Alicia Domínguez; Santos, Isabela Soares

    2006-08-01

    This article analyzes the level of progressivity in taxes financing the Brazilian Unified National Health System (SUS). Distribution of the tax burden financing the SUS was calculated using micro-data from the Household Budgets Survey, 2002-2003. The Kakwani index, which shows a tax system's level of progressivity, was calculated. The Kakwani index of public financing was -0.008, and SUS financing was nearly proportional to income. From a social justice perspective this is highly undesirable in a society like Brazil, with a Gini index of 0.57. The system should be clearly progressive in order to counterbalance the country's extreme income concentration.

  15. Antisense suppression of cucumber (Cucumis sativus L.) sucrose synthase 3 (CsSUS3) reduces hypoxic stress tolerance.

    PubMed

    Wang, Hongyun; Sui, Xiaolei; Guo, Jinju; Wang, Zhenyu; Cheng, Jintao; Ma, Si; Li, Xiang; Zhang, Zhenxian

    2014-03-01

    Sucrose synthase (SUS; EC 2.4.1.13) plays important roles in sugar metabolism and abiotic stress response. But the genes encoding SUS in cucumber (Cucumis sativus L.) have not been well studied. Here, we isolated four cucumber sucrose synthase genes (CsSUS). Among them, CsSUS3, which highly expressed in the roots, was chosen for further study. Immunolocalization and subcellular localization analysis indicated that CsSUS3 localized in the cytosol and the plasma membrane, and mainly existed in the companion cells of phloem in the roots. When suffering hypoxia stress from flooding, CsSUS3 expression and SUS activity in roots increased, especially in the lateral roots; moreover, the soluble SUS activity increased clearly, but the membrane fraction hardly changed. Compared with the wild-type cucumbers, the transgenic lines with antisense expression of CsSUS3 were more sensitive to flooding. After 6 d of flooding, the SUS activity, soluble sugar and uridine 5'-diphosphate glucose (UDPG) content and the ratio of ATP/ADP in the roots of transgenic plants were significantly lower than that in wild-type plants. Moreover, the transgenic lines grew more slowly with more yellow necrosis in the leaves. These findings suggested CsSUS3 participated in resisting hypoxic stress. Furthermore, the mechanism of CsSUS3 in resisting hypoxic stress was also discussed.

  16. [The construction of the 'SUS problem' in the newspaper Folha de S. Paulo].

    PubMed

    Silva, Gabriela Martins; Rasera, Emerson Fernando

    2014-01-01

    The article examines the process of discursive construction of the 'SUS problem' in reports published in the newspaper Folha de S. Paulo in 2008. Through an online search of the Folha archives, 667 news items were selected and then studied from the perspectives of critical discourse analysis and contributions from social constructionism. In methodological terms, at the text practice level of analysis, the investigation sought to determine what linguistic resources had been used to construct the SUS problem. At the discursive practice level of analysis, it further explored how the newspaper medium and the journalistic style influenced the production of these meanings. The article concludes that as this production constructs the SUS problem, it fosters a limited, negative view of the the Sistema Único de Saúde (Unified Healthcare System, or SUS) based on mistrust and on the notion that it is impossible to improve the system.

  17. Insights: Simple Models for Teaching Equilibrium and Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Russell, Joan M.

    1988-01-01

    Presents three models that have been effective for teaching chemical equilibrium and Le Chatelier's principle: (1) the liquid transfer model, (2) the fish model, and (3) the teeter-totter model. Explains each model and its relation to Le Chatelier's principle. (MVL)

  18. Insights: Simple Models for Teaching Equilibrium and Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Russell, Joan M.

    1988-01-01

    Presents three models that have been effective for teaching chemical equilibrium and Le Chatelier's principle: (1) the liquid transfer model, (2) the fish model, and (3) the teeter-totter model. Explains each model and its relation to Le Chatelier's principle. (MVL)

  19. Effects of LeY glycan expression on embryo implantation.

    PubMed

    Gu, J; Sui, L-L; Cui, D; Ma, Y-N; Zhu, C-Y; Kong, Y

    2016-08-01

    To investigate the correlation between LeY glycan expression and embryo implantation. Uterine epithelial cells before implantation were transfected with FUT1siRNA to inhibit FUT1 (the gene encoding the key enzyme of LeY synthesis) expression and treated with 10 ng/ml leukemia inhibitory factor (LIF). Murine embryo implantation model in vitro was prepared by late blastocysts with identical morphology and treated uterine epithelial cells co-culture. Using RT-PCR, dot blot and observation of embryo attachment to analyze FUT1 gene expression and LeY synthesis of uterine epithelial cells and studied further the correlation of LeY expression level and embryo implantation. FUT1 gene expression and LeY synthesis declined after cells were transfected with FUT1siRNA, and LIF promoted FUT1 expression and LeY synthesis. After expression of FUT1 gene was inhibited, attachment rate of embryos lowered, but LIF up-regulated FUT1 expression and increased the attachment rate of embryos. These results indicated regulating FUT1 expression affected LeY synthesis, and then LeY regulated the recognition and attachment of uterus-embryo and participates in embryo implantation further.

  20. Second Language Acquisition of the Chinese Particle "Le."

    ERIC Educational Resources Information Center

    Wen, Xiaohong

    1995-01-01

    This study investigated 14 English speakers' interlanguage constructions using the Chinese perfective aspect and the sentence-final modal particle. The results show that although the surface forms of the perfective aspect "-le" and the sentence-final "le" are identical, they are learned differently, with the perfective aspect…

  1. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-11-01

    Glace et éclairs; Astéroïdes; Pluton; Avatars et avanie d'une petite planète (Xena, Eris); Nuage d'éthane sur Titan; Lacs de Titan; La NASA scrute Mars; Les express Mars et Venus; Cydonia, le visage sur Mars; Transit d'Ariel; Lune; Gonflée, la planète; Terres, terres!; Une planète extrasolaire aurait abrité de l'eau liquide; Des planètes au centre de la Voie Lactée; Anatomie d'un disque protoplanétaire; CHRX73 et pseudo-planète; Systèmes étranges; Premières galaxies; Voie Lactée; Neutrinos; RCW 86

  2. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2009-10-01

    Dunes de Titan; Lac Ontario; Titan; Anneaux de Saturne; Jupiter; Mars; Rotation de Saturne; Valles Marineris; Méthane martien; Epsilon Aurigae; Glycine cométaire; HD 87643; Pluton; Bételgeuse; Site astronomique; Andromède cannibale; Attaque de trou noir; BD+44 493; Formation d'étoiles; Gaz manquant; LIGO; M87; Naine blanche; Galaxie satellite; Galaxies naines sphéroïdales; Galaxies trapues; Cygnus X-1; L'avenir de la Voie Lactée; Naphtaline cosmique; Premiers trous noirs; Coup de foudre; Effet de serre; Glace lunaire; Impacts et extinctions; Exoplanètes rétrogrades; Kepler; Planète chaude; Collision planétaire; Disques dans le vent; Exoplanètes; Formation des planètes; Taches et transits

  3. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  4. Automated Verification of Design Patterns with LePUS3

    NASA Technical Reports Server (NTRS)

    Nicholson, Jonathan; Gasparis, Epameinondas; Eden, Ammon H.; Kazman, Rick

    2009-01-01

    Specification and [visual] modelling languages are expected to combine strong abstraction mechanisms with rigour, scalability, and parsimony. LePUS3 is a visual, object-oriented design description language axiomatized in a decidable subset of the first-order predicate logic. We demonstrate how LePUS3 is used to formally specify a structural design pattern and prove ( verify ) whether any JavaTM 1.4 program satisfies that specification. We also show how LePUS3 specifications (charts) are composed and how they are verified fully automatically in the Two-Tier Programming Toolkit.

  5. L’apport de la dermoscopie dans le carcinome basosquameux

    PubMed Central

    Elmahi, Hakima; Lahlou, Asmae; Baybay, Hanane; Gallouj, Salim; Mernissi, Fatima Zahra; Reggad, Fatima Zahra; Harmouch, Taoufik

    2016-01-01

    Le carcinome basosquameux (CBS) est un cancer cutané rare qui présente des zones de carcinome basocellulaire (CBC) et de carcinome épidermoïde (SCC) et une zone de transition entre elles. Cependant, les caractéristiques dermoscopiques du BSC ne sont pas bien décrites dans la littérature, sauf deux études. Le but du présent cas était de mieux identifier et clarifier la contribution de la dermoscopie dans le diagnostic du BSC, malgré que la confirmation reste toujours histologique. PMID:28293368

  6. Les Hemorragies Gastroduodenales de Stress Chez le Brule Grave

    PubMed Central

    Siah, S.; Fouadi, F.E.; Ababou, K.; Nassim Sabah, T.; Ihrai, I.

    2008-01-01

    Summary Les Auteurs rapportent trois observations d'hémorragies gastroduodénales de stress chez le brûlé grave. Ils rappellent l'importance des mesures thérapeutiques qui doivent être prises chez le brûlé grave, comme le traitement du choc, du sepsis, des plaies et de la douleur, la nutrition entérale précoce et l'oxygénothérapie. Tout cela permet de réduire les facteurs de risque de survenue d'une hémorragie gastroduodénale de stress. PMID:21991137

  7. SusHi Bento: Beyond NNLO and the heavy- top limit

    NASA Astrophysics Data System (ADS)

    Harlander, Robert V.; Liebler, Stefan; Mantler, Hendrik

    2017-03-01

    Version 1.6.0 of the code SusHi is presented. Concerning inclusive CP-even Higgs production in gluon fusion, the following new features with respect to previous versions have been implemented: expansion of the partonic cross section in the soft limit, i.e. around x = MH2 / s ˆ → 1; N3LO QCD corrections in terms of the soft expansion; top-quark mass suppressed terms through NNLO; matching to the cross section at x → 0 through N3LO. For CP-even and -odd scalars, an efficient evaluation of the renormalization-scale dependence is included, and effects of dimension-5 operators can be studied, which we demonstrate for the SM Higgs boson and for a CP-even scalar with a mass of 750 GeV. In addition, as a generalization of the previously available b b ¯ → H cross section, SusHi_1.6.0 provides the cross section for charged and neutral Higgs production in the annihilation of arbitrary heavy quarks. At fixed order in perturbation theory, SusHi thus allows to obtain Higgs cross-section predictions in different models to the highest precision known today. For the SM Higgs boson of MH = 125 GeV, SusHi yields 48.28 pb for the gluon-fusion cross section at the LHC at 13 TeV. Simultaneously, SusHi provides the renormalization-scale uncertainty of ± 1 . 97 pb.

  8. Le point sur les amas de galaxies

    NASA Astrophysics Data System (ADS)

    Pierre, M.

    galaxies jouent donc un rôle de premier plan dans toute étude cosmologique et par conséquent, sont indispensables à notre compréhension globale de l'univers. Dans l'introduction générale, nous détaillons cet aspect fondamental en montrant comment l'étude des amas peut contribuer à contraindre les scénarios cosmologiques. Une fois le contexte scientifique délimité, les chapitres suivants s'attachent à présenter les diverses propriétés des amas et leur évolution cosmique observée dans diverses longueurs d'onde principalement dans les domaines visible (galaxies), X (gaz) et radio (gaz et particules). Nous verrons que l'étude détaillée d'un amas implique celle de l'interaction entre ses différentes composantes et est un passage obligé pour remonter au paramètre ultime (ou premier) qu'est sa masse. Loin d'être un détour ennuyeux, ceci sera l'occasion d'aborder des phénomènes physiques extrêmement variés tel l'aspect multi-phases du milieu intra-amas, les sursauts de formation d'étoiles et l'évolution morphologique des galaxies capturées par les amas, ou bien encore, l'interaction entre le plasma intra-amas et les particules relativistes accélérées lors de la fusion entre deux amas. Bien sûr, pour chaque longueur d'onde, nous ne manquerons pas de décrire simplement les techniques d'observation et d'analyse mises en oeuvre ; celles-ci sont particulièrement intéressantes dans le cas de l'instrumentation spatiale. Nous terminerons en présentant des projets d'observatoires pour l'horizon 2010 et leur impact prévu sur l'étude des amas de galaxies.

  9. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2007-09-01

    Anions interstellaires; S Orionis; Altaîr; Courants stellaires; Etoiles jeunes; 2MASSW J1207334-393254; Alpha Andromède; Etoiles à neutrons (1); LH54-425; AGNs invisibles; Deux supernovae; Les GRBs seon Swift; Peser les trous noirs; Formation de trous noirs; Trou noir; ondes gravitationnelles : Virgo entre dans sa phase d'exploitation scientifique; Amas de galaxies actifs; Amas de galaxies; Galaxies actives d'amas; L'univers statique: le retour; Macho; Exoplanètes; Exoplanètes habitables?; Exoplanètes habitables? (suite); Une année d'un an; Une année de 31 heures; Valse des Jupiters; Disque de HD 15115; Impact majeur; Planètes isolées; Super-Jupiter; Impact et mini-extinction; L'effet Pioneer; Toungouska; Spéléo martienne; Autres lunes dactives; Encelade; Hypérion; Pluton dépassé; Satellites d'Uranus; Titan

  10. Lymphoscintigraphy (LS) in lymphedema (LE) of the extremities

    SciTech Connect

    Gloviczki, P.; Vaqueiro, M.; Fisher, J.; Schirger, A.; Dewanjee, M.K.; Hollier, L.H.; Wahner, H.W.

    1985-05-01

    Twenty-two patients with primary and secondary LE and one with lipedema had LS using 0.4-0.6 mCi of Tc-99mSb2Sb3 subcutaneous at the second interdigital space. Three had excisional surgery, in four patients lympho-venous anastomosis (LVA) was attempted following LS. Results are presented in this paper. This study concludes that LS is a noninvasive method without side effects that visualizes the pattern of the lymphatic system in LE. If lymph channels were seen, LVA could be performed. LS seems adequate for patient selection and follow-up after LVA. It differentiated LE from lipedema. Image patterns or quantitative studies could not differentiate between primary and secondary LE.

  11. Microscopic Description of Le Châtelier's Principle

    NASA Astrophysics Data System (ADS)

    Novak, Igor

    2005-08-01

    The analysis based on microscopic descriptors (energy levels and their populations) is given that provides visualization of free energies and conceptual rationalization of Le Châtelier's principle. The misconception "nature favors equilibrium" is highlighted.

  12. LePaProGen—lepton pair production generator

    NASA Astrophysics Data System (ADS)

    Dydyshka, Ya. V.; Yermolchyk, V. L.; Suarez, J. H.; Shumeiko, N. M.

    2017-09-01

    A Monte Carlo generator "LePaProGen" for simulation of lepton pair production at hadron colliders is presented. Higher order electroweak radiative effects are implemented. A new algorithm for selection of the optimal phase space parameterization is applied.

  13. Some Aspects of the Teaching of "-Guo" and "-Le"

    ERIC Educational Resources Information Center

    Ma, Jing-heng S.

    1977-01-01

    This paper examines the two markers of Mandarin Chinese, "-guo" and "-le," and focuses primarily on areas of difficulty that the non-native speaker may encounter due to confusion of these markers. (CHK)

  14. CIM - A Manufacturing Paradigm (Le CIM - Un Nouveau Modele Industriel),

    DTIC Science & Technology

    1986-07-01

    fait la plupart des entreprises , ont affind le module de "Rgvolution industrielle". Nous vivons A l’poque du spdcialiste. Toutefois, le modale de sp...program will serve as an umbrella under which specific projects are planned, financed , managed, and imple- mented. Well defined corporate goals must be...assets. Through an integration of financing strategies an enterprise can focus on capital investment in shared, value-added assets such as databases

  15. Le Soleil et ses relations avec la Terre

    NASA Astrophysics Data System (ADS)

    Lang, Kenneth; Heidmann, M.

    C'est le 2e livre de K. Lang publié en français, considéré comme texte complementaire au célèbre Vagabonds de l'Espace qui avait gagné en 1994 le prix du livre d'astronomie en France. Maintenant l'auteur se concentre sur le système le plus élémentaire: l'étoile et son planète, et choisit celui qui est le plus intéressant pour nous: le Soleil et la Terre. Il a accumulé les observations terrestres et les plus récentes effectuées par des observatoires spatiales, et ceux des météorologues et géophysiciens, et nous présente un panorama fascinant du Soleil et ses relations avec la Terre. C'est la physique qui a les conséquences les plus fondamentales aux événements qui influencent notre environment, notre vie et même la condition humaine y inclu les arts et la litérature.

  16. Transmaxillary Sinus Approach for Le Fort II Osteotomy

    PubMed Central

    Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-01-01

    Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy. PMID:27014548

  17. Searching the animal psyche with Charles Le Brun.

    PubMed

    Cohen, Sarah R

    2010-07-01

    Around 1670 the French court painter and Academician Charles Le Brun produced a series of drawings featuring naturalistic animal heads, as well as imaginary heads in which he refashioned various nonhuman animal species to make humanoid physiognomies. What were the purpose and significance of these unusual works? I argue that they show Le Brun's interest in what we today would call animal psychology: focusing upon the sensory organs and their connections with the animal's brain, Le Brun studied his animals as conscious protagonists of the natural realm. One source that may have served him in this project was Marin Cureau de La Chambre's De la Connoissance des bestes of 1645, in which the physician argued that animals possess a conscious soul grounded in the senses. However, Le Brun's animal-humans have no clear place in the artist's taxonomy--nor, indeed, in any seventeenth-century understandings of species. It is rather John Locke, at his most skeptical, who offers the best parallel in the realm of natural philosophy to Le Brun's unsettling animal-humans. Probably without meaning to, Le Brun demonstrated through his eerie, boundary-crossing creatures the limits of visual classification.

  18. Le Point sur la Pharmacologie des Agents Anesthesiques Chez le Brule Grave

    PubMed Central

    Siah, S.; Ababou, K.; Benziane, H.; El Jaoudi; Bensghir, M.; Bakali, H.; El Wali, A.; Ihrai, I.; Drissi, N.K.

    2008-01-01

    Summary La pharmacologie des agents anesthésiques chez le brûlé est variable et imprévisible. Dans les premières 48 h, il y a une hypovolémie avec chute du débit cardiaque et des fuites plasmatiques. Après 48 h, il y a une hypervolémie avec augmentation du débit cardiaque, hypermétabolisme et la clearance des médicaments est augmentée. Parmi les facteurs de déséquilibre, on retrouve les variations des protéines plasmatiques. Deux protéines sont importantes chez le brûlé grave : l'albumine et l'alpha 1- glycoprotéine. Leur taux varie beaucoup au cours de l'évolution de la brûlure. Les agents anesthésiques dont la liaison avec ces deux protéines est prédominante verront leur pharmacocinétique modifiée. L'anesthésiste-réanimateur du service des brûlés va maîtriser ces notions pharmacologiques pour utiliser à bon escient les agents anesthésiques. PMID:21991108

  19. Etude de la transition tribologique entre le fretting et le meso-fretting pour des materiaux de contact electrique

    NASA Astrophysics Data System (ADS)

    Gagnon, Daniel

    Dans les installations electriques, les contacts sont toujours soumis a des contraintes alternees ou a des micro-deplacements. Il en resulte une corrosion par fretting, phenomene defini comme un type de deterioration de la surface qui se produit lorsque deux materiaux en contact sont soumis a des mouvements microscopiques d'oscillations de tres faible amplitude (0 a 100 mum). Ceci a pour effet de provoquer une degradation de la resistance de contact et une interruption du passage du courant. Ce phenomene a des repercussions considerables sur le plan pratique puisque les micro-deplacements de pieces en contact peuvent etre causes par la dilatation thermique differentielle des metaux, par des vibrations mecaniques, par la relaxation des contraintes ou par l'echauffement des contacts lorsqu'on interrompt et retablit le courant. Nous avons donc dans le cadre de cette these etudie plusieurs aspects du fretting (0--100 mum) et du meso-fretting (100 a 1000 mum) pour differents materiaux de contact electrique. Des travaux experimentaux ont ete realises a partir de deux montages reproduisant divers aspects de la degradation par le fretting. Un premier montage de fretting de type bille-plaque a ete entierement developpe a l'ETS et un second montage, de type fil-plaque a ete utilise en collaboration avec Hydro Quebec IREQ a Varennes. Plusieurs techniques de mesures et d'analyse relevant tant du domaine de la mecanique du contact que de la metallurgie ont ete utilisees pour traiter les resultats. L'influence du courant sur le taux d'usure et la force de friction a ete examinee pour divers materiaux de contacts. Des essais de fatigue thermique et electrique ont ete realises sur divers materiaux et lubrifiants de contact. Il a ete demontre que pour le domaine entre 100 mum et 1000 mum, le taux d'usure n'est pas le meme de 0 a 100 mum et au dela de 1000 mum. La plupart des materiaux evalues montrent un stade de comportement intermediaire dont le debut se situe entre 100 mum et

  20. Does Glucagon Improve Survival in a Porcine (Sus Scrofa) of Adult Asphyxial Cardiac Arrest in Addition to Standard Epinephrine Therapy?

    DTIC Science & Technology

    2012-01-17

    UDIIILI: oa. I..UN I ItA!.. I NUMDI:It Does Glucagon improve survival in a porcine (Sus Scrofa ) of adult asphyxial cardiac arrest in addition to...EXPIRATION DATE: 25 Mar 13 PROTOCOL TITLE: Does Glucagon Improve Survival in a Porcine (Sus scrofa ) Model of Adult Asphyxial Cardiac Arrest in Addition...Additions: Deletions: 2 Protocol No: A-2007-03 Protocol Title: Does Glucagon Improve Survival in a Porcine (Sus scrofa ) Model of Adult Asphyxial

  1. Transgenic switchgrass (Panicum virgatum L.) biomass is increased by overexpression of switchgrass sucrose synthase (PvSUS1).

    PubMed

    Poovaiah, Charleson R; Mazarei, Mitra; Decker, Stephen R; Turner, Geoffrey B; Sykes, Robert W; Davis, Mark F; Stewart, C Neal

    2015-04-01

    Sucrose synthase (SUS) converts sucrose and uridine di-phosphate (UDP) into UDP-glucose and fructose. UDP-glucose is used by the cellulose synthase to produce cellulose for cell wall biosynthesis. For lignocellulosic feedstocks such as switchgrass, the manipulation of cell walls to decrease lignin content is needed to reduce recalcitrance of conversion of biomass into biofuels. Of perhaps equal importance for bioenergy feedstocks is increasing biomass. Four SUS genes were identified in switchgrass. Each gene contained 14 or 15 introns. PvSUS1 was expressed ubiquitously in the tissues tested. PvSUS2 and PvSUS6 were highly expressed in internodes and roots, respectively. PvSUS4 was expressed in low levels in the tissues tested. Transgenic switchgrass plants overexpressing PvSUS1 had increases in plant height by up to 37%, biomass by up to 13.6%, and tiller number by up to 79% compared to control plants. The lignin content was increased in all lines, while the sugar release efficiency was decreased in PvSUS1-overexpressing transgenic switchgrass plants. For switchgrass and other bioenergy feedstocks, the overexpression of SUS1 genes might be a feasible strategy to increase both plant biomass and cellulose content, and to stack with other genes to increase biofuel production per land area cultivated.

  2. Synthesis of a BSA-Le(x) glycoconjugate and recognition of Le(x) analogues by the anti-Le(x) monoclonal antibody SH1: the identification of a non-cross reactive analogue.

    PubMed

    Wang, Jo-Wen; Asnani, Ari; Auzanneau, France-Isabelle

    2010-10-15

    A Le(x) trisaccharide functionalized with a cysteamine arm was prepared and this synthesis provided additional information on the reactivity of N-acetylglucosamine O-4 acceptors when they are glycosylated with trichloroacetimidate donors activated with excess BF(3)·OEt(2). In turn, this trisaccharide was conjugated to BSA lysine side chains through a squarate-mediated coupling. This BSA-Le(x) glycoconjugate displayed 35 Le(x) haptens per BSA molecule. The relative affinity of the anti-Le(x) monoclonal antibody SH1 for the Le(x) antigen and analogues of Le(x) in which the D-glucosamine, L-fucose or D-galactose residues were replaced with D-glucose, L-rhamnose and D-glucose, respectively, was measured by competitive ELISA experiments. While all analogues were weaker inhibitors than the Le(x) antigen, only the analogue of Le(x) in which the galactose residue was replaced by a glucose unit showed no binding to the SH1 mAb. To confirm that the reduced or loss of recognition of the Le(x) analogues by the anti-Le(x) mAb SH1 did not result from different conformations adopted by the analogues when compared to the native Le(x) antigen, we assessed the conformational behavior of all trisaccharides by a combination of stochastic searches and NMR experiments. Our results showed that, indeed, the analogues adopted the same stacked conformation as that identified for the Le(x) antigen. The identification of a trisaccharide analogue that does not cross-react with Le(x) but still retains the same conformation as Le(x) constitutes the first step to the design of a safe anti-cancer vaccine based on the dimeric Le(x) tumor associated carbohydrate antigen.

  3. Transitions de phase dans le oxyde de yttrium vanadium

    NASA Astrophysics Data System (ADS)

    Roberge, Benoit

    Dans le mémoire qui suit, les ordres structural, magnétiques et orbital dans le YVO3 sont étudiés avec l'aide de la diffraction des rayons X,de la spectroscopie Raman et de la technique de la cavité résonnante hyperfréquence. L'objectif premier consiste à observer l'évolution de ces ordres en fonction de la température. Le mémoire met ensuite en évidence le couplage entre les différents ordres cohabitants dans le YVO3 . Les mesures effectuées par la diffraction des rayons X permettent de mesurer le caractère polycrystallin des échantillons du YVO 3. Une comparaison de nos mesures avec des mesures de diffraction des rayons X faites sur la poudre de YVO3 indique la faible présence de maclage. Les mesures effectuées avec la technique de résonnance hyperfréquence permettent de suivre l'évolution de la constante diélectrique en fonction de la température. Les changements impliquant l'ordre orbital se manifestent de manière évidente dans la constante diélectrique à 200 K et à 77 K. La transition diélectrique détectée à 77 K est une transition de premier ordre. Un couplage entre les propriétés diélectriques et magnétiques est observable à la température de Néel à 114 K. L'effet d'un champ magnétique fixe sur la température de transition de l'ordre orbital survenant à 77 K est également remarquable. Cela indique un couplage magnétodiélectrique démontrant ainsi le caractère multiferroïque du YVO 3. Finalement, l'observation d'un mécanisme de relaxation pouvant être modélisé par le modèle d'Havriliak-Negami est observé en dessous de 77 K. En utilisant le modèle d'Arrhénius et le modèle d'Havriliak-Negami, on peut caractériser le mécanisme avec son énergie d'activation et son temps de relaxation. Les mesures effectuées en spectroscopie Raman permettent de suivre l'évolution de la structure du YVO3 en fonction de la température. Les deux changements structuraux survenant à 200 K et 77 K sont observés. Le

  4. Absence of bovine tuberculosis in feral swine (Sus scrofa) from the Southern Texas border region

    USDA-ARS?s Scientific Manuscript database

    Free-ranging wildlife, like feral swine (Sus scrofa), harbor a variety of diseases that are infectious to livestock and could negatively impact agricultural production. Information is lacking regarding the exposure and infection rates for bovine tuberculosis (Mycobacterium bovis; bTB), and many othe...

  5. 2013 Higher Education Summit/SUS Data Workshop Proceedings. Session: IRM Data Workshop

    ERIC Educational Resources Information Center

    Board of Governors, State University System of Florida, 2013

    2013-01-01

    Information Resource Management--State University System of Florida (IRM-SUS) is the primary collector and provider of data concerning state universities that is used to make sound education policy decisions. The office provides technical assistance to those using the information, state and federal reporting support, those supplying information,…

  6. Comparison of methods of extracting messenger Ribonucleic Acid from ejaculated Porcine (Sus Scrofa) Spermatozoa

    USDA-ARS?s Scientific Manuscript database

    H. D. Guthrie, G.R. Welch, and L. A. Blomberg. Comparison of Methods of Extracting Messenger Ribonucleic Acid from Ejaculated Porcine (Sus Scrofa) Spermatozoa. Biotechnology and Germplasm Laboratory, Agricultural Research Service U. S. Department of Agriculture, Beltsville, MD 20705 The purpos...

  7. Survey for selected pathogens in wild pigs (Sus scrofa) from Guam, Marianna Islands, USA

    USDA-ARS?s Scientific Manuscript database

    Pigs (Sus scrofa) were introduced to the United States Territory of Guam in the late 1600’s and are now feral, widespread and present in high densities on parts of the island. Feral pigs are reservoirs for pathogens of concern to domestic animals and humans. Although there are no data on pathogen ex...

  8. Evaluation of Endografts in the Setting of Noncompressible Torso Hemorrhage in Swine (Sus Scrofa)

    DTIC Science & Technology

    2016-01-06

    Title: Evaluation of Endografts in the Setting of Noncompressible Torso Hemorrhage in swine (Sus Scrofa) 4. Principal Investigator (PI): Name...behaves in vivo when used for traumatic injury and not for age related disease . We furthered current literature and can confirm that placement of this

  9. A Study of Instructional Faculty Salaries at USF, SUS and National Peers

    ERIC Educational Resources Information Center

    Micceri, Theodore

    2010-01-01

    This study investigates 10-year trends in instructional faculty salaries by sex and rank for USF, five SUS Peers (UF, FSU, FIU, UCF, FAU) and eight National Peers (North Carolina State, Alabama-Birmingham, Illinois-Chicago, California-Irvine, SUNY-Stony Brook, SUNY-Buffalo, Cincinnati, Rutgers). Methods: Historical instructional faculty salary…

  10. Development of nanostructured SUS316L-2%TiC with superior tensile properties

    NASA Astrophysics Data System (ADS)

    Sakamoto, T.; Kurishita, H.; Matsuo, S.; Arakawa, H.; Takahashi, S.; Tsuchida, M.; Kobayashi, S.; Nakai, K.; Terasawa, M.; Yamasaki, T.; Kawai, M.

    2015-11-01

    Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below Md (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90-270 nm, accompanied by TiC precipitates with 20-50 nm in grain interior and 70-110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6-21%, respectively, depending on the heat treatment temperature after rolling at -196 °C.

  11. Texture and phase analysis of deformed SUS304 by using HIPPO

    SciTech Connect

    Takajo, Shigehiro; Vogel, Sven C.

    2016-11-15

    These slides represent the author's research activity at Los Alamos National Laboratory (LANL), which is about texture and phase analysis of deformed SUS304 by using HIPPO. The following topics are covered: diffraction histogram at each sample position, diffraction histogram (all bank data averaged), possiblity of ε-phase, MAUD analysis with including ε-phase.

  12. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    Des mesures spectroscopiques effectuees avec un haut rapport signal sur bruit et une bonne resolution ont demontre l'existence de regions perturbees en mouvement dans le vent d'etoiles Wolf-Rayet (WR). L'echantillon d'objets etudies ici comprend 9 etoiles WR couvrant differents sous-types WN et WC. De nombreuses petites structures variables superposees au profil des raies d'emission formees dans le vent stellaire signalent la presence des perturbations. L'etude des variations globales des raies et l'examen des micro-structures individuelles ont permis de decrire plusieurs caracteristiques des perturbations. Entre autres, on observe des correlations significatives entre le niveau de variabilite des raies et certains parametres des etoiles qui confirment que le phenomene de variabilite est intrinseque au vent stellaire. En comparant les changements des vitesses radiales et des largeurs equivalentes des differentes raies d'une meme etoile, on conclut que les regions perturbees ont une etendue finie par rapport a l'enveloppe des etoiles. On peut facilement suivre les structures individuelles sur une periode de temps couvrant ~eq8 heures (et peut etre meme 24 heures) avant qu'elles ne disparaissent. Durant ce temps les structures se deplacent en s'eloignant du centre de la raie. A partir des differents comportements notes lors de l'analyse des variations globales et lors de l'examen des structures individuelles, on propose de representer les perturbations par un modele d'inhomogeneites discretes en expansion dans le vent. On suppose simplement que les inhomogeneites emettent comme le vent global (et absorbent aussi si le vent global montre un profil P Cyg). La superposition du graphique de l'acceleration radiale moyenne des inhomogeneites de WR140 en fonction de leur vitesse radiale et du modele theorique d'inhomogeneites qui suivent la loi generale de vitesse donne un taux d'acceleration lent, avec beta >= 3 pour les inhomogeneites de cette etoile. On obtient, entre

  13. Etude du Photochromisme et de la Photorefractivite dans le Poly

    NASA Astrophysics Data System (ADS)

    Ghailane, Fatima

    1995-11-01

    Nous avons etudie la possibilite d'utiliser un materiau organique, le poly(vinylcarbazole) comme milieu de stockage optique de masse en temps reel. Ce materiau dope aux photochromes presente un potentiel non negligeable pour l'holographie de volume en temps reel. Plusiers cycles, Ecriture-Lecture-Effacement, ont ete enregistres dans cette matrice polymerique avec une resolution assez elevee. Une etude a ete menee afin d'obtenir la valeur des parametres comme l'epaisseur du film et l'intensite d'ecriture pour un angle d'enregistrement theta_{ acute ecriture} donne qui permettent d'obtenir les meilleures efficacites diffractionelles tout en preservant ce milieu de tout effet de fatigue ou de degradation. Ce polymere devient photorefractif une fois melange avec un bon accepteur de charge, le trinitrofluorenone et un bon chromophore non-lineaire, le disperse orange 25. Nous avons etudie experimentalement la conductivite en obscurite et la photoconductivite de ce materiau. Des simulations numeriques ont ete realisees en se basant sur le modele de Poole-Frenkel. Nous avons aussi etudie l'implantation de faisceaux d'ions d'oxygene d'energie 200 keV pour inscrire dans le PVCz un guide d'onde plan a profil d'indice. Une etude ESCA complete cette partie afin de savoir les modifications induites par implementation ionique a l'interieur du film polymerique.

  14. Le syndrome des enfants battus: aspects cliniques et radiologiques

    PubMed Central

    Jlalia, Zied; Znaigui, Talel; Smida, Mahmoud

    2016-01-01

    La maltraitance physique des enfants ou le syndrome des enfants battus est responsable de plus de 75.000 décès par an en France. Ce problème de santé publique reste sous diagnostiqué en Tunisie et dans le monde. Le chemin a été laborieux pour la reconnaissance du syndrome des enfants battus dans certaines sociétés même occidentales. Nous avons voulus exposer ce problème aux praticiens afin qu'il soit mieux diagnostiqué et pris en charge. La maltraitance physique des enfants est appelée à tort syndrome de Silverman qui ne regroupe en fait que les lésions squelettiques chez ces enfants tels que les fractures. Mots clés: Fracture, maltraitance, enfant, neuro-radiologie PMID:27642408

  15. Le Fort I Maxillary Advancement Using Distraction Osteogenesis

    PubMed Central

    Combs, Patrick D.; Harshbarger, Raymond J.

    2014-01-01

    Treatment of maxillary hypoplasia has traditionally involved conventional Le Fort I osteotomies and advancement. Advancements of greater than 10 mm risk significant relapse. This risk is greater in the cleft lip and palate population, whose anatomy and soft tissue scarring from prior procedures contributes to instability of conventional maxillary advancement. Le Fort I advancement with distraction osteogenesis has emerged as viable, stable treatment modality correction of severe maxillary hypoplasia in cleft, syndromic, and noncleft patients. In this article, the authors provide a review of current data and recommendations concerning Le Fort I advancement with distraction osteogenesis. In addition, they outline their technique for treating severe maxillary hypoplasia with distraction osteogenesis using internal devices. PMID:25383054

  16. Le zona ophtalmique: une dermatose rare chez l'enfant

    PubMed Central

    Zakia, Douhi; Meziane, Marieme; Salim, Gallouj; Zahra, Mernissi Fatima

    2015-01-01

    Le zona est dû a une réactivation du virus varicelle-zona (VZV) qui reste quiescent dans les ganglions sensitifs dorsaux après la varicelle. Le zona de l'enfant est rare et particulièrement la forme ophtalmique, qui peut être responsable de complications oculaires graves nécessitant une prise en charge adéquate et précoce. Il est parfois associé à des douleurs post-zostériennes dont le traitement est difficile. L'aciclovir per os administré dans les 72 heures après l’éruption a prouvé son efficacité dans la prévention des complications oculaires. Nous en rapportant un nouveaux cas chez un garçon immunocompétent de 9 ans, sans notion de varicelle antérieure. PMID:26955408

  17. The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract

    PubMed Central

    Wengier, Diego; Valsecchi, Isabel; Cabanas, María Laura; Tang, Wei-hua; McCormick, Sheila; Muschietti, Jorge

    2003-01-01

    After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the specific dephosphorylation of LePRK2 suggested that these kinases might interact with signaling molecules in the style extracellular matrix. Here, we show that LePRK1 and LePRK2 can be coimmunoprecipitated from pollen or when expressed together in yeast. In yeast, their association requires LePRK2 kinase activity. In pollen, LePRK1 and LePRK2 are found in an ≈400-kDa protein complex that persists on pollen germination, but this complex is disrupted when pollen is germinated in vitro in the presence of style extract. In yeast, the addition of style extract also disrupts the interaction between LePRK1 and LePRK2. Fractionation of the style extract reveals that the disruption activity is enriched in the 3- to 10-kDa fraction. A component(s) in this fraction also is responsible for the specific dephosphorylation of LePRK2. The style component(s) that dephosphorylates LePRK2 is likely to be a heat-stable peptide that is present in exudate from the style. The generally accepted model of receptor kinase signaling involves binding of a ligand to extracellular domains of receptor kinases and subsequent activation of the signaling pathway by receptor autophosphorylation. In contrast to this typical scenario, we propose that a putative style ligand transduces the signal in pollen tubes by triggering the specific dephosphorylation of LePRK2, followed by dissociation of the LePRK complex. PMID:12748390

  18. Biochemical and Molecular Characterization of RcSUS1, a Cytosolic Sucrose Synthase Phosphorylated in Vivo at Serine 11 in Developing Castor Oil Seeds*

    PubMed Central

    Fedosejevs, Eric T.; Ying, Sheng; Park, Joonho; Anderson, Erin M.; Mullen, Robert T.; She, Yi-Min; Plaxton, William C.

    2014-01-01

    Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of 32Pi from [γ-32P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes. PMID:25313400

  19. Biochemical and molecular characterization of RcSUS1, a cytosolic sucrose synthase phosphorylated in vivo at serine 11 in developing castor oil seeds.

    PubMed

    Fedosejevs, Eric T; Ying, Sheng; Park, Joonho; Anderson, Erin M; Mullen, Robert T; She, Yi-Min; Plaxton, William C

    2014-11-28

    Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of (32)P(i) from [γ-(32)P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes.

  20. Délais de prise en charge des syndromes coronariens aigus avec sus-décalage du segment ST à Ouagadougou et facteurs associés à un allongement de ces délais: étude transversale à propos de 43 cas colligés au CHU-Yalgado Ouédraogo

    PubMed Central

    Yameogo, Nobila Valentin; Samadoulougou, André; Millogo, Georges; Kologo, Koudougou Jonas; Kombassere, Karim; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2012-01-01

    La prise en charge de l'infarctus du myocarde est une course contre la montre et les trois premières heures constituent les « golden hours ». Les objectifs de ce travail étaient de déterminer le délai de prise en charge des infarctus du myocarde du myocarde au Burkina Faso, les facteurs liés à un allongement du délai et le pronostic des patients. Il s'agit d'une étude transversale descriptive menée de Septembre 2010 à Août 2011. Le critère d'inclusion était l'infarctus du myocarde dont le diagnostic était basé sur des critères clinique (douleur angineuse), électrocardiographique (sus-décalage persistant du segment ST dans au moins deux dérivations contiguës du même territoire coronaire, onde Q de nécrose) et biologique (élévation de la troponine). Les informations relatives au délai de prise en charge ont été recueillies: début du premier symptôme, contact avec le premier agent de santé et le cardiologue, nombre de centre de santé consulté avant le transfert en cardiologie, situation géographique des patients, moyen de transport utilisé. Les données ont été analysées grâce au logiciel SPSS version 17. Durant la période d’étude, 43 patients d’âge moyen de 56,51 ± 12,91 ans ont été admis pour infarctus du myocarde. Plus de la moitié des patients (72,0%) habitait Ouagadougou et sa banlieue. Le délai moyen entre le début de la douleur et la consultation dans la première structure sanitaire était de 48 ± 20,8 heures; celui entre le début de la douleur et la réalisation du premier ECG était en moyenne de 8,6 ±4,5 jours. Le délai entre la réalisation de l'ECG et l'admission dans le service de cardiologie était de 4,35 ±4,0 jours [00 heure et 13 jours]. Le délai entre l'admission dans le service de cardiologie et la thrombolyse était de 34 minutes. Enfin le délai entre le début de la douleur et le contact avec le cardiologue était de 9,6±3,5 jours. Il n'y avait pas de différence statiquement

  1. The complete mitochondrial genome of European wild boar, Sus scrofa scrofa.

    PubMed

    Hu, Xiao-Di; Yang, Xiao-Tian; Yang, En

    2016-09-01

    In this study, we report the complete mitochondrial genome sequence of the European wild boar, Sus scrofa scrofa for the first time. The genome is found to be 16,770 bp in length and has a base composition of A (34.63%), G (13.38%), C (26.21%), and T (25.78%), indicating that the percentage of A + T (60.41%) was higher than G + C (39.59%). Similar to other pigs, it contains a typically conserved structure including 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 control region (D-loop). Most of the genes were located on the H-strand except for the ND6 gene and eight tRNA genes. The complete mitochondrial genome sequence provided here would add a new genetic resource and new study on the evolution of the genus Sus.

  2. Effect of Pulse Current on the Tensile Deformation of SUS304 Stainless Steel

    NASA Astrophysics Data System (ADS)

    Li, Xifeng; Wang, Shen; Zhao, Shuangjun; Ding, Wei; Chen, Jun; Wu, Guohong

    2015-12-01

    The effect of pulse current on the mechanical properties of SUS304 metastable austenitic stainless steel was studied by tension test with and without air-cooling under different current densities. The microstructural variations at different conditions were also studied by SEM, TEM, and Feritscope. A negative effect on the plasticity was observed when current pulse was applied without air-cooling. But when Joule heating resulting from current pulse was excluded by air-cooling, the elongation of SUS304 stainless steel was increased to 72.4% at a current density of 2.95 A/mm2, which is 23.3% higher than that tested without pulse current at room temperature. Pulse current can decrease the dislocation density and dislocation pile-ups. Furthermore, EP effect from pulse current can accelerate martensitic transformation and enhance TRIP effect. The mechanism of current-induced martensitic transformation was discussed from Gibbs free energy change.

  3. Effect of Harmonic Microstructure on the Corrosion Behavior of SUS304L Austenitic Stainless Steel

    NASA Astrophysics Data System (ADS)

    Rai, Prabhat K.; Shekhar, S.; Nakatani, M.; Ota, M.; Vajpai, S. K.; Ameyama, K.; Mondal, K.

    2016-12-01

    Corrosion behavior of a harmonic structured SUS304L austenitic stainless steel was examined and compared with nonharmonic structured SUS304L stainless steel and conventional 304 stainless steel in 3.5 pct NaCl solution. The study was performed using linear polarization, potentiodynamic polarization, cyclic polarization, and a salt fog exposure test for 30 days. Characterization was accomplished using a scanning electron microscope, an electron probe microanalyzer, and Raman spectroscopy. Improved pitting corrosion resistance was found in the case of the harmonic structured steel as compared to that of the nonharmonic and the conventional 304 stainless steel. Harmonically distributed fine-grained structure, less porosity, and higher fraction of passive α-FeOOH are attributed to the improvement in corrosion resistance of the harmonic structured steel.

  4. Hispanos en la EPA: Rafael DeLeón

    EPA Pesticide Factsheets

    La diversidad de la fuerza laboral es importante para la Agencia de Protección Ambiental de EE.UU. (EPA, por sus siglas en inglés). Los empleados hispanos de la EPA contribuyen diariamente hacia la protección de la salud y el medio ambiente.

  5. Presence of antibodies against Aujeszky's disease virus in wild boar (Sus scrofa) in Slovenia.

    PubMed

    Vengust, Gorazd; Valencak, Zdravko; Bidovec, Andrej

    2005-10-01

    Serum samples from 427 hunter-killed wild boar (Sus scrofa) from Slovenia were tested for antibodies to Aujeszky's disease virus (ADV). Samples were collected throughout Slovenia and corresponded to 6.2% of the total harvest. Antibodies against ADV were detected in 111 sera (26%) using a commercial enzyme-linked immunosorbent assay (ELISA). Antibody prevalence increased significantly with age. This report describes the first evidence of ADV infection in wild boar populations in Slovenia.

  6. Residual stress and fracture characteristics of zirconia/metal(Ni, SUS304) functionally gradient materials

    SciTech Connect

    Jung, Yeon-Gil; Choi, Sung-Churl; Paik, Un-Gyu

    1995-09-01

    To analyze the residual stress and the fracture behavior of FGMs. disc-type TZP/Ni- and TZP/SUS304-FGM were hot passed, and compared with MM& The continuous interface and the microstructure of FGMs were characterized with EPMA, optical microscopy and SEM. The defect-like cracks in the FGMs induced by the preferential shear stress have been shown to cause fracture. This fact has well corresponded to the analysis of the residual stress distribution by FEM.

  7. [The Brazilian Unified Health System (SUS) is universal, but quotas are the norm].

    PubMed

    Viegas, Selma Maria da Fonseca; Penna, Cláudia Maria de Mattos

    2013-01-01

    In the context of the Unified Health System (SUS), health actions and services constitute a social right to be guaranteed by the State and managed under the responsibility of three autonomous spheres of government. This is a holistic multiple case study with a qualitative approach based on the assumptions of Comprehensive Everyday Sociology, which originated from a PhD thesis. It sought to understand the construction of comprehensive health practices in the daily work of family health teams and managers of the cities in Vale do Jequitinhonha - Minas Gerais, Brazil. The individuals studied were professionals from the Family Health Teams, support staff and managers with a total of 48 participants. In order to reveal the construction of the whole, the data show that "SUS is universal, but quotas are the norm." Bearing in mind its limitations, it is difficult to ensure that SUS is a right for all. Thus, regulation is essential to order, guide, define and optimize the use of resources available for comprehensive care and also guarantee public access to actions and services in a timely and equitable manner.

  8. Changes to soil bacterial profiles as a result of Sus scrofa domesticus decomposition.

    PubMed

    Olakanye, Ayodeji O; Thompson, Tim; Komang Ralebitso-Senior, T

    2014-12-01

    The importance of cadaver decomposition knowledge for clandestine grave location cannot be over emphasised. Notwithstanding this, only a limited understanding is available on the resulting soil microbial community dynamics. To address this paucity, a pig leg (Sus scrofa domesticus; 5kg) was buried in freshly weighed (20kg) sandy loamy soil in a sealed microcosm (40cm height) in parallel with a soil only control. Both microcosms were perforated nine times at equal distances and maintained outside. Soil samples were collected through these perforations from the top (0-10cm), middle (10-20cm) and bottom (20-30cm) segments every three days for the first two weeks, and then weekly up to 14 weeks. PCR-DGGE gels quantified by 1D Phoretix showed increases in the cumulative soil community richness values of 43, 66 and 106 for the top, middle and bottom segments, respectively, in the presence of Sus scrofa domesticus. Shannon-Wiener's (H') and Simpon's (D) indices confirmed corresponding species diversity increases in the middle (H'=1.58-2.33; D=0.79-0.91) and bottom (H'=2.48-3.16; D=0.85-0.95) depths between days 10 and 71 compared with the control. In contrast, similar evenness was recorded for all segments in both the Sus scrofa domesticus and control soils.

  9. Torque teno sus virus (TTV) detection in aborted and slaughterhouse collected foetuses.

    PubMed

    Martínez-Guinó, L; Kekarainen, T; Maldonado, J; Aramouni, M; Llorens, A; Segalés, J

    2010-07-15

    The aim of this study was to estimate the presence of Torque teno sus virus (TTV) species in pig foetuses in order to assess the possible relationship between swine TTV infection and abortion in swine. A total of 98 abortion cases and foetuses collected from 55 pregnant sows at slaughterhouse were analysed by PCR for the presence of Torque teno sus virus 1 (TTV1) and Torque teno sus virus 2 (TTV2). All foetuses were necropsied and relevant tissues were collected, pooled, and submitted to DNA extraction. The overall prevalence of swine TTV1 and TTV2 in aborted foetuses (n = 98) was 17.0% and 29.6%, respectively. For slaughterhouse collected foetuses (n = 55), 10.9% were TTV1 PCR positive and 40.0% were positive for TTV2. There were no statistically significant differences when comparing prevalence of swine TTVs by type of sample (aborted versus slaughterhouse collected foetuses) or by gestation stage. The present work represents the first description of swine TTV infection in pig foetuses at different stages of gestation. Results obtained confirm that vertical transmission is an important route of TTVs dissemination. In addition, data obtained suggest that swine TTVs should not be considered as infectious agents responsible for abortion occurrence.

  10. High temperature joint properties with palladium alloys for SUS316L and Inconel 600

    SciTech Connect

    Izui, Hiroshi; Suezawa, Yoshifumi

    1995-12-31

    Newly developed Pd-Ag-Mn system braze alloys were considered for use in brazing stainless steel SUS316L or Ni-based alloy Inconel 600 for engine applications. Palladium braze alloys were selected because of their oxidation resistance, ductility, relatively high melting points, and lower cost than gold-based braze alloys. The reactions and microstructures were studied in experimental brazed joints between these base metals and the braze alloys. Tensile tests of the joints were carried out at room temperature, 473K, 673K, 873K, and 1,073K. The maximum tensile strengths of the joints brazed with 30Pd-60Ag-10Co at room temperature were 445MPa in the SUS316L joints and 456MPa in the Inconel 600 brazed joints. The SUS316L joints brazed with the braze alloys had tensile strengths of 320MPa to 200MPa from 473K to 1,73K. The Inconel 600 joints brazed with the 30Pd-50Ag-10Mn-10Co alloy had tensile strengths of 289MPa to 162MPa from 473K to 1,073K.

  11. [Whose is SUS? About the social representation of the users of the Family Health Program].

    PubMed

    Martins, Poliana Cardoso; Cotta, Rosângela Minardi Mitre; Mendes, Fábio Farias; Priore, Silvia Eloiza; Franceschinni, Sylvia do Carmo Castro; Cazal, Mariana de Melo; Batista, Rodrigo Siqueira

    2011-03-01

    The present study analyzes the representation of the users of SUS and PSF, presenting data obtained by semi-structured interviews, using the theoretical referential of the qualitative research. The results show a social representation marked by a focused vision and assistance, pointing to the concentration of public resources in poor segments of the society and centered in the biomedical model of attention. It stands out that PSF did not reach their objectives to provide changes in the praxis in health. In relation to the social control, it is observed that only 5.9% of the interviewees know the CMS. The presented data show a great ignorance by the studied population on the sanitary system and conquered social laws, and many people still see SUS as a "health plan for the poor". Due to the lived reality, the need of the implementation of strategies is emphasized for the reach of larger powerment/liberation of the population, seeking to build effective possibilities so that their actors will be active participant of the process of construction of a common project, actually based on the democratic ideals of SUS, being PSF strategically important in the accomplishment of these actions.

  12. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN*

    PubMed Central

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    Objective To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Materials and Methods Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. Results The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Conclusion Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS. PMID:25741070

  13. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN.

    PubMed

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS.

  14. [Evaluation of emergency services of the hospitals from the QualiSUS program].

    PubMed

    O'Dwyer, Gisele Oliveira; de Oliveira, Sergio Pacheco; de Seta, Marismary Horsth

    2009-01-01

    The aid lent by the emergency services is the object of this paper, which aims to assess the emergency service of the QualiSUS program. The study is descriptive with the application of a questionnaire to the responsible of the emergency services in eight hospitals. The emergency services were always overcrowded, and the causes pointed were the low resolutivity of basic attention and the precariousness of the hospital network. Contributing to this there is the primary care decreased resolutivity and the precariousness of the hospital network. Six hospitals do not manage the emergency service. The entrance system is not organized and only three hospitals work with risk classification. All of them refer difficulties with internal and external services. The hardest pathologies to refer to other services are the chronicles, neurological and social. The professionals do not have specific qualification and the precariousness job contracts do not contribute neither for the professional's fixation nor for his qualification. Clinical protocols are used by one service. It was noticed the influence of the QualiSUS in the hospitals. The failure of the health services network interferes with the emergency patient's profile. The investment of the QualiSUS cannot be restrained to the hospital. Emergency should be more integrated to the system and hospital. The qualification of human resources is indispensable as well as the bed's regulation.

  15. [Integral care, a SUS (Brazilian Unified Health System) guideline for the sanitary surveillance].

    PubMed

    O'Dwyer, Gisele; Reis, Daniela Carla de Souza; da Silva, Luciana Leite Gonçalves

    2010-11-01

    The sanitary surveillance (Visa) performs several practices, on different objects and its actions are guided by principles and guidelines of the SUS. It was done a critical reflection on the interaction conditions of practice in Visa, with a constitutional proposition of the SUS: integral care. The analysis was based on the theory of structuration (Giddens) that considers mobilization of structural resources as dimensions of social interaction, which would justify the legitimacy exercised since the standards. Have been analyzed the following categories: Visa and its insertion within the SUS; the integral care and the Visa; and political impediments. The Visa has been organized by National Health Surveillance Agency. Nowadays it has as sanitary responsibilities, communication with society and health promotion. The proposal of the literature concerning integral care is based on the assistance issue. The organization of the services in the different federative entities is the sense of integral care most adopted by Visa. Political impediments focus on the institutional renewal, on the conflicts of interest arena, on the distance between formulated policies and established practices and gaps concerning work management and the insufficiency of financial support.

  16. Occurrence and first molecular characterization of Sarcocystis spp. in wild boars (Sus scrofa) and domestic pigs (Sus scrofa domesticus) in Romania: Public health significance of the isolates.

    PubMed

    Imre, Kálmán; Sala, Claudia; Morar, Adriana; Imre, Mirela; Ciontu, Cătălin; Chisăliță, Ion; Dudu, Andreea; Matei, Marius; Dărăbuș, Gheorghe

    2017-03-01

    Domestic and wild pigs, as intermediate hosts, can harbor tissue cysts of three Sarcocystis species namely S. miescheriana, S. suihominis and S. porcifelis. Out of them, S. suihominis is zoonotic. Romania is a country with high consumption of raw and/or undercooked traditional pork products. This fact may greatly favor the acquiring of the zoonotic Sarcocystis infections by humans, as definitive host. Based on this consideration and in order to investigate the occurrence and public health significance of Sarcocystis spp. in two western counties (Caraş-Severin and Timiş) of Romania, a total of 165 heart samples from hunted wild boars (Sus scrofa, n=101) and home slaughtered domestic pigs (Sus scrofa domesticus, n=64) were screened using microscopic fresh examination and molecular methods. Microscopic examination revealed the presence of sarcocysts in 60.4% of wild boars, and 23.4% of domestic pigs. Genetic characterization of isolates through the PCR-RFLP procedure, targeting the 18S rRNA gene, was successfully achieved for all microscopically positive samples, indicating the presence of a single species, S. miescheriana, in both hosts. The identity of 13 selected S. miescheriana isolates was also confirmed through sequencing. The tested hosts older than 27 months were found to be significantly higher infected (p<0.05) with Sarcocystis than the 6 to ≤27months age group. Although the human infective S. suihominis has not been registered, for a more reliable epidemiological picture, further molecular studies enrolling a larger number of animals and diagnosis on human intestinal Sarcocystis infections are still necessary.

  17. Le Chatelier's Principle and the Prediction Temperature on Solubilities.

    ERIC Educational Resources Information Center

    Fernandez-Prini, R.

    1982-01-01

    Discusses Le Chatelier's Principle from a thermodynamic perspective and applies it to the effect of temperature on the solubility of gases in liquids. Rationale of this discussion is to evaluate data in a previous article claimed to be contradictory to the Principle. (Author/JN)

  18. Le Chatelier's Principle Applied to the Temperature Dependence of Solubility.

    ERIC Educational Resources Information Center

    Treptow, Richard S.

    1984-01-01

    One effect of temperature is its influence on solubility, and that effect is used as a common example when teaching Le Chatelier's principle. Attempts to clarify the question of whether the principle holds in the case of the solubility of ionic compounds in water by investigating the literature data in detail. (JN)

  19. Expectation of "Le Petit Prince"'s home

    NASA Astrophysics Data System (ADS)

    Abe, Masanao; Ohba, Yohei; Ishiguro, Masateru; Hasegawa, Sunao; Fuse, Tetsuharu

    2002-11-01

    We observed a few hundred meter-sized asteroid like "Le Petit Prince"'s home using Subaru telescope. The name of the asteroid is 1998 SF36, which is a target object of the Japanese asteroid sample return mission, MUSES-C. We report the results of the observations and expect the true picture of the tiny-sized asteroid.

  20. Le Dernier Cartoucherie: Refuge and the Performance of Care

    ERIC Educational Resources Information Center

    Fisek, Emine

    2008-01-01

    In 2003, the Paris-based theatre company Theatre du Soleil launched "Le Dernier Caravanserail: Odyssees", a collaborative creation based on stories that company members had collected from refugees at the Sangatte refugee camp outside Calais, among other locations. Scenes of moral reasoning dotted the six-hour spectacle, calling to mind…

  1. LHC, le Big Bang en éprouvette

    ScienceCinema

    None

    2016-07-12

    Notre compréhension de l’Univers est en train de changer… Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l’innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  2. Some special features of the le chatelier-braun principle

    NASA Astrophysics Data System (ADS)

    Nesis, E. I.; Skibin, Yu. N.

    2000-07-01

    The relaxation reaction of a system that follows from the Le Chatelier-Braun principle and weakens the result of an external influence turns out to be more intense under a complex action. A method for quantitative determination of the weakening effect for simple and complex actions is suggested.

  3. Le Chatelier's Principle and the Prediction Temperature on Solubilities.

    ERIC Educational Resources Information Center

    Fernandez-Prini, R.

    1982-01-01

    Discusses Le Chatelier's Principle from a thermodynamic perspective and applies it to the effect of temperature on the solubility of gases in liquids. Rationale of this discussion is to evaluate data in a previous article claimed to be contradictory to the Principle. (Author/JN)

  4. Ursula LeGuin's Magical World of Earthsea.

    ERIC Educational Resources Information Center

    Griffin, Jan M.

    1996-01-01

    Discusses how Ursula LeGuin's Earthsea Trilogy reflects her belief in Taoist philosophy as well as her skill in telling stories of magic and adventure. Notes that the three books can be described as coming-of-age novels in which three separate individuals struggle to become mature, responsible, whole adults. (RS)

  5. LePera Career Activity Program. Final Report.

    ERIC Educational Resources Information Center

    Truby, Max E.

    The purpose of the research project was to determine the effectiveness of a comprehensive career orientation program in increasing awareness of self and of career opportunities in students of rural areas. Conducted with grades 7 and 8 in LePera school in Parker, Arizona from May 1973 to October 1974, the program provided occupational information…

  6. Decolonizing the Choctaws: Teaching LeAnne Howe's "Shell Shaker"

    ERIC Educational Resources Information Center

    Hollrah, Patrice

    2004-01-01

    "Shell Shaker" (2001) by LeAnne Howe (Choctaw) is a novel that gives students an opportunity to learn that the history and culture of the Choctaw Nation of Oklahoma are alive today. Winner of the Before Columbus Foundation American Book Award in 2002, the novel deals with two parallel stories that converge in the present, one about the eighteenth…

  7. Errol Le Cain: The Very Best Aspects of Book Illustration.

    ERIC Educational Resources Information Center

    Eve, Matthew

    1999-01-01

    Examines Errol Le Cain's eclectic illustration contributions to children's literature throughout his life. Relates life experiences and influences to his work as an illustrator. Suggests that he constantly changed and adapted his style according to the prose, its tone, and the setting, unlike most other contemporary British book artists. (SC)

  8. MoLeNET Mobile Learning Conference 2009: Research Papers

    ERIC Educational Resources Information Center

    Guy Parker, Ed.

    2010-01-01

    The Mobile Learning Network (MoLeNET) is a unique collaborative approach to encouraging, supporting, expanding and promoting mobile learning, primarily in English post-14 education and training, via supported shared cost mobile learning projects. Collaboration at national level involves participating institutions and the Learning and Skills…

  9. Restorative Justice Scripts in Ursula K. Le Guin's "Voices"

    ERIC Educational Resources Information Center

    Oziewicz, Marek C.

    2011-01-01

    This essay examines restorative justice scripting in "Voices", the second volume of Ursula K. Le Guin's "Annals of the Western Shore." Narrated by a rape-child, "Voices" is the story of an occupied city-state and of how the conquered and the conquerors negotiate a formula for peaceful coexistence. They are able to do…

  10. Le Chatelier's Principle Applied to the Temperature Dependence of Solubility.

    ERIC Educational Resources Information Center

    Treptow, Richard S.

    1984-01-01

    One effect of temperature is its influence on solubility, and that effect is used as a common example when teaching Le Chatelier's principle. Attempts to clarify the question of whether the principle holds in the case of the solubility of ionic compounds in water by investigating the literature data in detail. (JN)

  11. Decolonizing the Choctaws: Teaching LeAnne Howe's "Shell Shaker"

    ERIC Educational Resources Information Center

    Hollrah, Patrice

    2004-01-01

    "Shell Shaker" (2001) by LeAnne Howe (Choctaw) is a novel that gives students an opportunity to learn that the history and culture of the Choctaw Nation of Oklahoma are alive today. Winner of the Before Columbus Foundation American Book Award in 2002, the novel deals with two parallel stories that converge in the present, one about the eighteenth…

  12. MoLeNET Mobile Learning Conference 2009: Research Papers

    ERIC Educational Resources Information Center

    Guy Parker, Ed.

    2010-01-01

    The Mobile Learning Network (MoLeNET) is a unique collaborative approach to encouraging, supporting, expanding and promoting mobile learning, primarily in English post-14 education and training, via supported shared cost mobile learning projects. Collaboration at national level involves participating institutions and the Learning and Skills…

  13. Computer Assisted Instruction: The Game "Le Choc des Multinationales."

    ERIC Educational Resources Information Center

    Cramer, Hazel

    "Le Choc de Multinationales" is a microcomputer game for students in an upper-level commercial French couse, to be played by two opponents, one of whom may be another student or the computer itself as a direct business competitor. The game's requirements for language use and knowledge of business and economics theory and principles are moderate,…

  14. The Discourse Function of the Verbal Suffix -Le in Mandarin.

    ERIC Educational Resources Information Center

    Chu, Chauncey C.; Chang, W. Vincent

    It is proposed that the functions of the Mandarin verbal suffix "-le" are three: (1) for marking non-continual factual actions or events; (2) for indicating the "peak" in an event line; and (3) for explicitly marking anteriority of an action or event. Observations of written language drawn from newspaper articles and…

  15. Les enfants et le theatre (Children and the Theater).

    ERIC Educational Resources Information Center

    Ferrari, Josephine

    1980-01-01

    Describes a project involving the presentation of "Le petit prince" as an exercise in dramatics by children in a French-Italian bilingual education class. Two steps in the process are discussed: (1) the study of the text, and (2) the activities involved in getting the play ready for performance. (AMH)

  16. Le Dernier Cartoucherie: Refuge and the Performance of Care

    ERIC Educational Resources Information Center

    Fisek, Emine

    2008-01-01

    In 2003, the Paris-based theatre company Theatre du Soleil launched "Le Dernier Caravanserail: Odyssees", a collaborative creation based on stories that company members had collected from refugees at the Sangatte refugee camp outside Calais, among other locations. Scenes of moral reasoning dotted the six-hour spectacle, calling to mind…

  17. LHC, le Big Bang en éprouvette

    SciTech Connect

    2010-04-07

    Notre compréhension de l’Univers est en train de changer… Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l’innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  18. LeRC in-house experimental research

    NASA Technical Reports Server (NTRS)

    Lyons, Valerie J.

    1992-01-01

    The topics covered include the following: LeRC in-house experimental research; combustion concepts; schedule for in-house experiments; lean premixed prevaporized combustion; comparisons of low NO(x) lean premixed/prevaporized data; rich burn/quick quench/lean burn (RQL); RQL combustion; fuel rich catalytic combustion; advanced diagnostics; and ceramic matrix liner test rig.

  19. Normal cellular prion protein is a ligand of selectins: binding requires LeX but is inhibited by sLeX

    PubMed Central

    Li, Chaoyang; Wong, Poki; Pan, Tao; Xiao, Fan; Yin, Shaoman; Chang, Binggong; Kang, Shin-Chung; Ironside, James; Sy, Man-Sun

    2007-01-01

    The normal PrPC (cellular prion protein) contains sLeX [sialyl-LeX (Lewis X)] and LeX. sLeX is a ligand of selectins. To examine whether PrPC is a ligand of selectins, we generated three human PrPC–Ig fusion proteins: one with LeX, one with sLeX, and the other with neither LeX nor sLeX. Only LeX-PrPC–Ig binds E-, L- and P-selectins. Binding is Ca2+-dependent and occurs with nanomolar affinity. Removal of sialic acid on sLeX-PrPC–Ig enables the fusion protein to bind all selectins. These findings were confirmed with brain-derived PrPC. The selectins precipitated PrPC in human brain in a Ca2+-dependent manner. Treatment of brain homogenates with neuraminidase increased the amounts of PrPC precipitated. Therefore the presence of sialic acid prevents the binding of PrPC in human brain to selectins. Hence, human brain PrPC interacts with selectins in a manner that is distinct from interactions in peripheral tissues. Alternations in these interactions may have pathological consequences. PMID:17497959

  20. Drosophila Suppressor of Sable Protein [Su(s)] Promotes Degradation of Aberrant and Transposon-Derived RNAs▿

    PubMed Central

    Kuan, Yung-Shu; Brewer-Jensen, Paul; Bai, Wen-Li; Hunter, Cedric; Wilson, Carrie B.; Bass, Sarah; Abernethy, John; Wing, James S.; Searles, Lillie L.

    2009-01-01

    RNA-binding proteins act at various stages of gene expression to regulate and fine-tune patterns of mRNA accumulation. One protein in this class is Drosophila Su(s), a nuclear protein that has been previously shown to inhibit the accumulation of mutant transcripts by an unknown mechanism. Here, we have identified several additional RNAs that are downregulated by Su(s). These Su(s) targets include cryptic wild-type transcripts from the developmentally regulated Sgs4 and ng1 genes, noncoding RNAs derived from tandemly repeated αβ/αγ elements within an Hsp70 locus, and aberrant transcripts induced by Hsp70 promoter transgenes inserted at ectopic sites. We used the αβ RNAs to investigate the mechanism of Su(s) function and obtained evidence that these transcripts are degraded by the nuclear exosome and that Su(s) promotes this process. Furthermore, we showed that the RNA binding domains of Su(s) are important for this effect and mapped the sequences involved to a 267-nucleotide region of an αβ element. Taken together, these results suggest that Su(s) binds to certain nascent transcripts and stimulates their degradation by the nuclear exosome. PMID:19687295

  1. Le syndrome d'embolie graisseuse post traumatique

    PubMed Central

    Berdai, Adnane Mohamed; Shimi, Abdelkarim; Khatouf, Mohammed

    2014-01-01

    Le syndrome d'embolie graisseuse est une complication grave des fractures des os longs, il est la conséquence de la dissémination des particules graisseuses dans la microcirculation. L'objectif de ce travail est de déterminer le profil épidémiologique, la présentation clinique et paraclinique de ce syndrome et sa prise en charge thérapeutique. Notre étude porte sur 11 cas de syndrome d'embolie graisseuse colligés au service de réanimation A1 au centre hospitalier universitaire Hassan II de Fès, de Janvier 2009 à Juin 2012. Le diagnostic positif est basé sur les critères de Gurd. Les cas collectés se caractérisent par la prédominance du sexe masculin, d'un âge inférieur à 40 ans, présentant une fracture fémorale. Ce syndrome survient souvent dans les 72 heures après le traumatisme. La présentation clinique est dominée par l'hypoxémie et les troubles de conscience. Sur le plan biologique: l'anémie et la thrombopénie sont les manifestations les plus fréquentes. La prise en charge est symptomatique, 63% des patients ont nécessité l'intubation et la ventilation. L’évolution n'est pas toujours bénigne. Nos résultats confirme le polymorphisme de la présentation clinique et paraclinique du syndrome d'embolie graisseuse. Le diagnostic de ce syndrome se base sur des critères cliniques, mais reste essentiellement un diagnostic d’élimination. La prise en charge est symptomatique. La prévention de ce syndrome est essentielle et se base sur une fixation précoce des fractures des os longs. PMID:25452829

  2. Simultaneous transgenic suppression of LePG and LeExp1 influences fruit texture and juice viscosity in a fresh market tomato variety.

    PubMed

    Powell, Ann L T; Kalamaki, Mary S; Kurien, Philip A; Gurrieri, Sergio; Bennett, Alan B

    2003-12-03

    Tomatoes are grown for fresh consumption or for processing of the fruit. Some ripening-associated processes of the fruit can either contribute to or degrade attributes associated with both fresh and processing quality. For example, cell wall disassembly is associated with loss of fresh fruit firmness as well as with loss of processed tomato product viscosity. Several enzymes contribute to cell wall polysaccharide disassembly. Polygalacturonase (PG, poly[1,4-alpha-d-galactouronide] glucanohydrolase, EC 3.2.1.15) is among the most abundant polysaccharide hydrolases in ripening tomato fruit and is the major contributor to pectin depolymerization. Expansin (LeExp1) is also abundant in ripening fruit and is proposed to contribute to cell wall disassembly by nonhydrolytic activity, possibly by increasing substrate accessibility to other enzymes. Suppression of either LePG or LeExp1 expression alone results in altered softening and/or shelf life characteristics. To test whether simultaneous suppression of both LePG and LeExp1 expression influences fruit texture in additive or synergistic ways, transgenic Lycopersicon esculentum var. Ailsa Craig lines with reduced expression of either LePG or LeExp1 were crossed. Fruits from the third generation of progeny, homozygous for both transgenic constructs, were analyzed for firmness and other quality traits during ripening on or off the vine. In field-grown transgenic tomato fruit, suppression of LeExp1 or LePG alone did not significantly increase fruit firmness. However, fruits suppressed for both LePG and LeExp1 expression were significantly firmer throughout ripening and were less susceptible to deterioration during long-term storage. Juice prepared from the transgenic tomato fruit with reduced LePG and LeExp1 expression was more viscous than juice prepared from control fruit.

  3. Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2

    PubMed Central

    Pascual-García, Pau; Govind, Chhabi K.; Queralt, Ethel; Cuenca-Bono, Bernardo; Llopis, Ana; Chavez, Sebastián; Hinnebusch, Alan G.; Rodríguez-Navarro, Susana

    2008-01-01

    Gene transcription, RNA biogenesis, and mRNA transport constitute a complicated process essential for all eukaryotic cells. The transcription/export factor Sus1 plays a key role in coupling transcription activation with mRNA export, and it resides in both the SAGA and TREX2 complexes. Moreover, Sus1 is responsible for GAL1 gene gating at the nuclear periphery, which is important for its transcriptional status. Here, we show that Sus1 is required during transcription elongation and is associated with the elongating form of RNA Polymerase II (RNAP II) phosphorylated on Ser5 and Ser2 of the C-terminal domain (CTD). In addition, Sus1 copurifies with the essential mRNA export factors Yra1 and Mex67, which bind to the mRNA cotranscriptionally. Consistently, ChIP analysis reveals that Sus1 is present at coding regions dependent on transcription in a manner stimulated by Kin28-dependent CTD phosphorylation. Strikingly, eliminating the TREX2 component Sac3 or the SAGA subunit Ubp8 partially impairs Sus1 targeting to coding sequences and upstream activating sequences (UAS). We found, unexpectedly, that Sgf73 is necessary for association of Sus1 with both SAGA and TREX2, and that its absence dramatically reduces Sus1 occupancy of UAS and ORF sequences. Our results reveal that Sus1 plays a key role in coordinating gene transcription and mRNA export by working at the interface between the SAGA and TREX2 complexes during transcription elongation. PMID:18923079

  4. Le traitement familial des enfants et des adolescents anorexiques : Des lignes directrices pour le médecin communautaire

    PubMed Central

    Findlay, S; Pinzon, J; Taddeo, D; Katzman, DK

    2010-01-01

    L’anorexie mentale (AM) est une maladie grave qui met la vie en danger et qui fait généralement son apparition pendant l’adolescence. Les données probantes au sujet du traitement optimal de l’AM chez les enfants et les adolescents sont en croissance, mais il reste beaucoup à apprendre. Même si les démarches thérapeutiques actuelles varient au Canada et ailleurs, les données jusqu’à présent indiquent que le traitement familial (TF) est le plus efficace pour les enfants et les adolescents anorexiques. Un élément essentiel du modèle de TF, c’est que les parents sont investis de la responsabilité de rétablir la santé physique de leur enfant et de s’assurer de la reprise complète de son poids. Le médecin qui comprend les principes fondamentaux et la philosophie du TF peut mettre en place les éléments de cette intervention fondée sur des faits probants auprès des jeunes patients anorexiques et de leur famille.

  5. Connecting Instructional and Cognitive Aspects of an LE: A Study of the Global Seminar Project

    ERIC Educational Resources Information Center

    Savelyeva, Tamara

    2012-01-01

    My research problem is based on the lack of unifying conceptual cohesion between the discourses concerning cognitive and instructional aspects of learning environments (LE). I contrast that lack with practical developments of LE studies connected at the level of practical implementation and evaluation. Next, I briefly review the LE boundaries,…

  6. Le contrôle de commutations dans une cellule bidirectionnelle bicommandable

    NASA Astrophysics Data System (ADS)

    Guillaud, X.; Deleu, A.; Degobert, P.; Hautier, J. P.

    1996-01-01

    A Power electronics static converter modulate the energy flowing between two different source types. This induce constraints in converter topology which need to be taken into account to drive the switches specially during the changeover between two switches belonging to the same cell. If the control logic is well known when using current or voltage bidirectionnal switches, we propose a method which fits to bidrivable, current and voltage bidirectionnal switches. Petri net are usefull tools to describe the switches themselves. Aplied to the cell description they permit us to generate a component logic drive in respect with energy constraints. Un convertisseur statique réalise une fonction de modulation de l'énergie transitant entre deux sources de nature différente. La nécessaire continuité énergétique induit des contraintes dans la topologie du convertisseur qui se répercutent sur la commande des composants qui le constituent, notamment lors de la phase de commutation entre deux interrupteurs d'une même cellule. Si les principes de commande sont bien connus pour les interrupteurs bidirectionnels en courant ou en tension, nous proposons dans cet article une méthode s'appliquant aux interrupteurs bicommandables et bidirectionnels à la fois en courant et en tension. Les réseaux de Petri constituent d'abord un outil de description précis des interrupteurs. Appliqués ensuite à la description du fonctionnement d'une cellule de commutation, ils deviennent alors un outil de synthèse conduisant à l'élaboration d'une logique de commande respectant les contraintes énergétiques dans tous les cas de figure.

  7. Pierre Curie et lele de la symétrie dans les lois physiques

    NASA Astrophysics Data System (ADS)

    de Gennes, P. G.

    Pierre et Jacques Curie découvraient il y a cent ans le phénomène de piézoélectricité : comment un cristal, de suffisamment basse symétrie, développe une polarization lorsqu'il est soumis à une contrainte mécanique. Pierre Curie n'a alors que 21 ans ! Et pourtant ses notes lapidaires aux Comptes Rendus datées de 1880 et 1881 [1] portent en elles tout l'essentiel du phénomène : charges superficielles proportionnelles à la pression, indépendantes de l'épaisseur du cristal, etc. Lorsque quelques mois plus tard, Lippmann prédit l'effet inverse (déformation du crystal sous champ électrique), les frères Curie imaginent tout de suite un dispositif admirablement simple pour détecter ces très faibles déformations. Ils couplent mécaniquement le cristal étudié avec un deuxième cristal piézoélectrique qui joue lele d'un détecteur; ce dernier transforme le signal mécanique du premier cristal en un signal électrique mesuré a l'électromètre ! Les résultats confirment brillamment la prédiction de Lippmann. Et pourtant, les moyens engagés sont très modestes — les champs électriques, par exemple, sont calibrés par la longueur d'une décharge dans l'air…

  8. Differentiation of European wild boar (Sus scrofa scrofa) and domestic swine (Sus scrofa domestica) meats by PCR analysis targeting the mitochondrial D-loop and the nuclear melanocortin receptor 1 (MC1R) genes.

    PubMed

    Fajardo, Violeta; González, Isabel; Martín, Irene; Rojas, Marı A; Hernández, Pablo E; Garcı A, Teresa; Martín, Rosario

    2008-03-01

    This work describes the differentiation of European wild boar (Sus scrofa scrofa) and domestic swine (Sus scrofa domestica) meats by PCR targeting sequences from two molecular markers: the mitochondrial displacement loop (D-loop) region and the nuclear melanocortin receptor 1 (MC1R) gene. A polymorphic D-loop fragment (∼270bp) was amplified and sequenced in a number of wild and domestic Sus scrofa meat samples, to find a nucleotide region suitable for PCR-RFLP analysis. Sequence data showed the presence of only a few point mutations across Sus scrofa D-loop sequences, not allowing direct discrimination between wild boar and domestic swine meats. Later, the MC1R gene was targeted and Sus scrofa-specific primers designed to amplify a 795bp MC1R fragment. Subsequent RFLP analysis of the MC1R swine-specific amplicons allowed selection of BspHI and BstUI endonucleases to carry out intraspecific Sus scrofa differentiation. Digestion of MC1R amplicons with the chosen enzymes generated characteristic PCR-RFLP profiles that allowed discrimination among meats from wild and domestic swine specimens. The technique also enabled the detection of samples that yielded heterozygous profiles, suggesting hybrids resulting from wild boar and domestic pig breeding. The PCR-RFLP reported here, targeting the MC1R gene may be routinely applied to verify the correct labelling of game products.

  9. Detection of Echinococcus granulosus G3 in a Wild Boar ( Sus scrofa ) in Central Italy Using PCR and Sequencing.

    PubMed

    Di Paolo, Antonella; Piseddu, Toni; Sebastianelli, Martina; Manuali, Elisabetta; Corneli, Sara; Paniccià, Marta; Papa, Paola; Viali, Selina; Mazzone, Piera

    2017-01-24

    We report cystic echinococcosis in a free-living wild boar ( Sus scrofa ) in Europe. Parasites were identified by histopathology and molecular techniques, revealing Echinococcus granulosus of the G3 genotype.

  10. [Methodology for construction of a panel of indicators for monitoring and evaluation of unified health system (SUS) management].

    PubMed

    Tamaki, Edson Mamoru; Tanaka, Oswaldo Yoshimi; Felisberto, Eronildo; Alves, Cinthia Kalyne de Almeida; Drumond Junior, Marcos; Bezerra, Luciana Caroline de Albuquerque; Calvo, Maria Cristina Marino; Miranda, Alcides Silva de

    2012-04-01

    This study sought to develop methodology for the construction of a Panel for the Monitoring and Evaluation of Management of the Unified Health System (SUS). The participative process used in addition to the systematization conducted made it possible to identify an effective strategy for building management tools in partnership with researchers, academic institutions and managers of the SUS. The final systematization of the Panel selected indicators for the management of the SUS in terms of Demand, Inputs, Processes, Outputs and Outcomes in order to provide a simple, versatile and useful tool for evaluation at any level of management and more transparent and easier communication with all stakeholders in decision-making. Taking the management of the SUS as the scope of these processes and practices in all normative aspects enabled dialog between systemic theories and those which consider the centrality of the social actor in the decision-making process.

  11. SUS-BAR: a database of pig proteins with statistically validated structural and functional annotation

    PubMed Central

    Piovesan, Damiano; Profiti, Giuseppe; Martelli, Pier Luigi; Fariselli, Piero; Fontanesi, Luca; Casadio, Rita

    2013-01-01

    Given the relevance of the pig proteome in different studies, including human complex maladies, a statistical validation of the annotation is required for a better understanding of the role of specific genes and proteins in the complex networks underlying biological processes in the animal. Presently, approximately 80% of the pig proteome is still poorly annotated, and the existence of protein sequences is routinely inferred automatically by sequence alignment towards preexisting sequences. In this article, we introduce SUS-BAR, a database that derives information mainly from UniProt Knowledgebase and that includes 26 206 pig protein sequences. In SUS-BAR, 16 675 of the pig protein sequences are endowed with statistically validated functional and structural annotation. Our statistical validation is determined by adopting a cluster-centric annotation procedure that allows transfer of different types of annotation, including structure and function. Each sequence in the database can be associated with a set of statistically validated Gene Ontologies (GOs) of the three main sub-ontologies (Molecular Function, Biological Process and Cellular Component), with Pfam functional domains, and when possible, with a cluster Hidden Markov Model that allows modelling the 3D structure of the protein. A database search allows some statistics demonstrating the enrichment in both GO and Pfam annotations of the pig proteins as compared with UniProt Knowledgebase annotation. Searching in SUS-BAR allows retrieval of the pig protein annotation for further analysis. The search is also possible on the basis of specific GO terms and this allows retrieval of all the pig sequences participating into a given biological process, after annotation with our system. Alternatively, the search is possible on the basis of structural information, allowing retrieval of all the pig sequences with the same structural characteristics. Database URL: http://bar.biocomp.unibo.it/pig/ PMID:24065691

  12. First molecular identification of Sarcocystis miescheriana (Protozoa, Apicomplexa) from wild boar (Sus scrofa) in Iran.

    PubMed

    Kia, Eshrat Beigom; Mirhendi, Hossein; Rezaeian, Mostafa; Zahabiun, Farzaneh; Sharbatkhori, Mitra

    2011-03-01

    Sarcocystis isolate obtained from the thigh muscle of a wild boar (Sus scrofa), captured from Gilan Province, northern Iran, was subjected to molecular analysis. Genomic DNA was obtained using a DNA extraction tissue kit and Polymerase chain reaction (PCR) for amplification of the 18S ribosomal DNA region yielded an 842 bp DNA band on agarose gel. Analysis of DNA sequencing by BLAST confirmed the isolate as Sarcocystis miescheriana and the sequence was deposited in GenBank by Accession No. GU395554. This is the first molecular identification of an isolate of S. miescheriana in Iran.

  13. A Serosurvey for Brucellosis in Wild Boar (Sus scrofa) in Sardinia, Italy.

    PubMed

    Pilo, Cristian; Addis, Giuseppe; Deidda, Manuela; Tedde, Maria Tania; Liciardi, Manuele

    2015-10-01

    Porcine brucellosis is a zoonotic disease caused by Brucella suis and hosted by pigs (Sus scrofa). Both domestic pigs and wild boars are affected. We measured the prevalence of antibody to Brucella spp. in wild boars in Sardinia, Italy. During 1 November 2009 to 31 January 2010, we collected 570 serum samples from legally hunted wild boars and tested them using a commercial competitive enzyme-linked immunosorbent assay. Sex and age class of the sampled wild boars were also recorded. Thirty-five samples were positive for an apparent antibody prevalence of 6.1%. Antibody prevalences did not differ between sexes or among age classes.

  14. Prevalence of antibodies to Toxoplasma gondii in South Korean wild boar (Sus scrofa coreanus).

    PubMed

    Jeong, Wooseog; Yoon, Hachung; Kim, Yong Kwan; Moon, Oun-Kyong; Kim, Do-Soon; An, Dong-Jun

    2014-10-01

    Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite and a commonly encountered pathogen in humans and animals. The wild boar (Sus scrofa coreanus) is considered a good indicator when monitoring environmental contamination by T. gondii. We surveyed the prevalence of antibodies against T. gondii in wild boars from South Korea. Blood samples were collected from 426 wild boars captured in eight provinces of South Korea during the hunting seasons in 2008-12. Antibodies against T. gondii were detected using an indirect enzyme-linked immunosorbent assay in samples from 152 of boars, indicating an overall antibody prevalence of 36% (95% confidence interval=31-40%).

  15. Necropsy and coprology in wild boar (Sus scrofa) in Livorno Mountain Park (Tuscany, Central Italy).

    PubMed

    Magi, M; Bertani, M; Dell'Omodarme, M; Prati, M C

    2004-09-01

    The present research analyses the reliability of coprological tests, both quantitative and qualitative, as indicators of the parasite burden of hosts, using data from wild boars (Sus scrofa) living in Livorno Mountain Park (Tuscany, Central Italy). In the case of intestinal strongyles, which turned out to be the dominant helminths of wild boars, the qualitative coprological test appears as a bad predictor of the real parasite situation of the herds, due to the high number of false negative results (34 animals out of 68). On the other hand, the positive predictive value of the test is high (90%). The quantitative test is significantly correlated with the individual parasite burden of wild boars.

  16. Epidemiologic study of lung parasites (Metastrongylus spp.) in wild boar (Sus scrofa) in southwestern Spain.

    PubMed

    García-González, Ángela María; Pérez-Martín, Juan Enrique; Gamito-Santos, José Antonio; Calero-Bernal, Rafael; Alcaide Alonso, María; Frontera Carrión, Eva María

    2013-01-01

    We analyzed 927 wild boars (Sus scrofa) in southwestern Spain during the hunting seasons of 2004/2005 to 2008/2009. Respiratory tracts were examined for lung nematodes (Metastrongylus spp.). The prevalence of Metastrongylus spp. was 41.1%. The most frequently isolated species were Metastrongylus apri (71.4%), Metastrongylus pudendotectus (28.0%), and Metastrongylus salmi (0.6%). Prevalence and infection intensity were greater in young animals (<1 yr old) than in older animals. There were no significant differences in prevalence between sexes. Prevalence and intensity of infection were higher in areas of high altitude and high rainfall.

  17. Ultrafast intramolecular charge transfer with N-(4-cyanophenyl)carbazole. Evidence for a LE precursor and dual LE + ICT fluorescence.

    PubMed

    Galievsky, Victor A; Druzhinin, Sergey I; Demeter, Attila; Mayer, Peter; Kovalenko, Sergey A; Senyushkina, Tamara A; Zachariasse, Klaas A

    2010-12-09

    The photophysics of N-(4-cyanophenyl)carbazole (NP4CN) was investigated by using absorption and fluorescence spectra, picosecond fluorescence decays, and femtosecond transient absorption. In the nonpolar n-hexane as well as in the polar solvent acetonitrile (MeCN), a locally excited (LE) state is detected, as a precursor for the intramolecular charge transfer (ICT) state. A LE → ICT reaction time τ(2) at 22 °C of 0.95 ps in ethyl cyanide (EtCN) and 0.32 ps in MeCN is determined from the decay of the LE excited state absorption (ESA) maximum around 620 nm. In the ESA spectrum of NP4CN in n-hexane at a pump-probe delay time of 100 ps, an important contribution of the LE band remains alongside the ICT band, in contrast to what is observed in EtCN and MeCN. This shows that a LE ⇄ ICT equilibrium is established in this solvent and the ICT reaction time of 0.5 ps is equal to the reciprocal of the sum of the forward and backward ICT rate constants 1/(k(a) + k(d)). In the photostationary S(0) → S(n) absorption spectrum of NP4CN in n-hexane and MeCN, an additional CT absorption band appears, absent in the sum of the spectra of its electron donor (D) and acceptor (A) subgroups carbazole and benzonitrile. This CT band is located at an energy of ∼4000 cm(-1) lower than for N-phenylcarbazole (NPC), due to the larger electron affinity of the benzonitrile moiety of NP4CN than the phenyl subunit of NPC. The fluorescence spectrum of NP4CN in n-hexane at 25 °C mainly consists of a structured LE emission, with a small ICT admixture, indicating that a LE → ICT reaction just starts to occur under these conditions. In di-n-pentyl ether (DPeE) and di-n-butyl ether (DBE), a LE emission is found upon cooling at the high-energy edge of the ICT fluorescence band, caused by the onset of dielectric solvent relaxation. This is not the case in more polar solvents, such as diethyl ether (DEE) and MeCN, in which a structureless ICT emission band fully overlaps the strongly quenched LE

  18. Sur le chaos Lagrangien dans une cuve elliptique

    NASA Astrophysics Data System (ADS)

    Saatdjian, E.; Chassaing, M. I.; Midoux, N.; André, J. C.

    1995-02-01

    A viscous fluid is introduced into the annular space between two concentric, confocal ellipses. The inner and outer walls can be displaced along their circumference. A small quantity of fluorescent dye is introduced into the fluid and deformation and mixing are studied for the case of periodic boundary movement. An analytical solution in elliptical coordinates has been previously derived for creeping flow conditions. Poincaré sections for a given set of parameters indicate that counter-rotation leads to a more chaotic behaviour than co-rotation, this result is confirmed experimentally. This geometry can also be used as a heat exchanger. By a suitable choice of the parameters, the heat transfer for steady boundary motion can be increased by more than 50% with respect to the concentric cylinder system. If the inner and outer walls are displaced time-periodically, the heat transfer rate obtained can be more than double the rate obtained between concentric cylinders. Un fluide visqueux est introduit dans une cuve de géométrie elliptique, les parois interne et externe de cette cuve tournent suivant le périmètre de l'ellipse. Une petite quantité de traceur fluorescent est introduite dans le fluide et la déformation de l'élément marqué, lorsque le mouvement des deux parois est périodique, est étudiée. Pour cet écoulement où le nombre de Reynolds est très inférieur à 1 (régime de Stokes) et à partir d'une solution analytique récemmnent obtenue pour le cas stationnaire, des sections de Poincaré ont été tracées pour le cas d'une contra-rotation et d'une co-rotation. Les résultats expérimentaux montrent que, pour un protocole de mélange discontinu approprié, cette géométrie mène vers un mélange chaotique après un petit nombre de périodes. Par ailleurs, il est préférable de faire tourner les ellipses en contra-rotation. Ce résultat, en contradiction avec ceux déjà obtenus dans l'espace annulaire entre cylindres excentrés tournants, est

  19. Cytochrome b based genetic differentiation of Indian wild pig (Sus scrofa cristatus) and domestic pig (Sus scrofa domestica) and its use in wildlife forensics.

    PubMed

    Gupta, Sandeep Kumar; Kumar, Ajit; Hussain, Syed Ainul; Vipin; Singh, Lalji

    2013-06-01

    The Indian wild pig (Sus scrofa cristatus) is a protected species and listed in the Indian Wildlife (Protection) Act, 1972. The wild pig is often hunted illegally and sold in market as meat warranting punishment under law. To avoid confusion in identification of these two subspecies during wildlife forensic examinations, we describe genetic differentiation of Indian wild and domestic pigs using a molecular technique. Analysis of sequence generated from the partial fragment (421bp) of mitochondrial DNA (mtDNA) cytochrome b (Cyt b) gene exhibited unambiguous (>3%) genetic variation between Indian wild and domestic pigs. We observed nine forensically informative nucleotide sequence (FINS) variations between Indian wild and domestic pigs. The overall genetic variation described in this study is helpful in forensic identification of the biological samples of wild and domestic pigs. It also helped in differentiating the Indian wild pig from other wild pig races. This study indicates that domestic pigs in India are not descendent of the Indian wild pig, however; they are closer to the other wild pig races found in Asia and Europe. Copyright © 2012 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

  20. Le facteur XII de la coagulation: bien plus qu’un stabilisant de la fibrine

    PubMed Central

    Messaoudi, N.; Lamaalmi, F.; Chakour, M.; Belmekki, A.; Naji, M.

    2011-01-01

    Summary Les Auteurs considèrent lele du facteur XIII de la coagulation dans la cicatrisation. Identifié depuis 1923, lele du facteur XIII ou le facteur stabilisant de la fibrine dans la coagulation a été bien élucidé. Son rôle dans la cicatrisation suggéré dès 1960 est méconnu par les hématologistes et les médecins prenant en charge les brûlés. Les Auteurs se proposent de mettre la lumière sur ce rôle, qui reste encore mystérieux et mérite d’être élucidé. PMID:21991236

  1. Le Fort I Approach for Midline Tumors of the Palate.

    PubMed

    de Cevallos, Jorge Guiñales Díaz; Carretero, Jose L Cebrián; de Vera, Jose L Del Castillo Pardo; García, Miguel Burgueño

    2015-12-01

    Midline tumors of the palate may represent a challenge for the maxillofacial surgeon. Their resection and immediate reconstruction could be hindered when a simply intraoral approach is selected. The Le Fort I downfracture approach represents an ideal technique for the management of this tumors, simplifying their resection, ensuring a tumor-free margin, and allowing their reconstruction with a temporal muscle flap. A review of this procedure is presented, highlighting the technical keys and its principal advantages.

  2. [Complications in Le Fort facial fractures combined with craniocerebral trauma].

    PubMed

    Dimov, Zh; Abramov, G; Dimov, K; Kr'stev, N; Kr'stev, D

    1999-01-01

    The present research is based on the most frequent traumas and fractures in the middle zone of the face (second and third type by Rene le Fort) and the proceeded from them complications for a period of four years in the clinic of Neurosurgery in NIUMN "Pirogov". From the 280 patients that were studied the complications were observed in 54 of them. We worked up the received results statistically and presented them in drawing.

  3. Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

    PubMed Central

    Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

    2011-01-01

    L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

  4. Accuracy of a LeFort I maxillary osteotomy.

    PubMed

    Semaan, Steven; Goonewardene, Mithran S

    2005-11-01

    An optimal outcome of combined surgery and orthodontics involving the maxilla is dependent on many factors. Accurate placement of the maxilla by the surgical team is ultimately of paramount importance. The aim of this retrospective study was to evaluate the accuracy of LeFort I maxillary osteotomy with respect to the presurgical prediction. The sample comprised 42 patients (33 females, nine males) who had undergone LeFort I osteotomy procedure alone or in combination with a mandibular osteotomy with or without genioplasty. Tracings of presurgical and immediate postsurgical lateral cephalograms and surgical predictions were digitized and compared using Quick Ceph software analysis. Vertical and horizontal measurements to various skeletal landmarks were used to assess the discrepancy between the predicted maxillary position and the actual postsurgical result. Statistically significant differences were found between the predicted and actual postsurgical maxillary molar vertical position, and significant differences were also found for the palatal plane angular measurements. Two surgical teams were compared, and surgical team 1 had significantly less variation in the surgical outcomes than did surgical team 2. When single-jaw and bimaxillary surgery were compared, no significant differences were found. Similarly, there were no statistically significant differences found when assessing the primary direction of movement (impaction vs downgraft vs advancement). Overall, 66% of the results were within two mm of prediction and 26% of the results were within one mm of prediction. A LeFort I maxillary osteotomy can be an accurate procedure with a wide range of discrepancy.

  5. Airborne pollen and spores of León (Spain)

    NASA Astrophysics Data System (ADS)

    Fernández-González, Delia; Suarez-Cervera, María; Díaz-González, Tomás; Valencia-Barrera, Rosa María

    1993-06-01

    A qualitative and quantitative analysis of airborne pollen and spores was carried out over 2 years (from September 1987 to August 1989) in the city of León. Slides were prepared daily using a volumetric pollen trap, which was placed on the Faculty of Veterinary Science building (University of León) 12m above ground-level. Fifty-one pollen types were observed; the most important of these were: Cupressaceae during the winter, Pinus and Quercus in spring, and Poaceae, Leguminosae and Chenopodiaceae in the summer. The results also showed the existence of a rich mould spore assemblage in the atmosphere. The group of Amerospores ( Penicillium, Aspergillus and Cladosporium) as well as Dictyospores ( Alternaria) were the most abundant; Puccinia was common in the air in August. Fluctuations in the total pollen and spores m3 of air were compared with meteorological parameters (temperature, relative humidity and rainfall). From the daily sampling of the atmosphere of León, considering the maximum and minimum temperature and duration of rainfall, the start of the pollen grain season was observed generally to coincide with a rise in temperature in the absence of rain.

  6. Le sumatriptan intranasal pour la migraine chez les enfants

    PubMed Central

    Goldman, Ran D.; Meckler, Garth D.

    2015-01-01

    Résumé Question Je vois de plus en plus d’enfants et d’adolescents qui souffrent de céphalées pouvant se classer dans la catégorie des migraines. J’ai fait des lectures sur le sumatriptan par voie intranasale comme thérapie abortive. Est-ce un traitement efficace? Réponse La migraine aiguë chez les enfants et les adolescents est fréquente et difficile à traiter. Le sumatriptan intranasal est une option sûre et généralement efficace pour les enfants et les adolescents. La dose actuellement recommandée est de 20 mg pour les enfants qui pèsent plus de 40 kg et de 10 mg pour ceux dont le poids se situe entre 20 et 39 kg. Il faudrait faire des études de plus grande envergure pour contrecarrer les limitations des échantillons de petite taille et mieux comprendre la faible concentration plasmique et les effets placebo observés dans les études jusqu’à présent.

  7. Sequence diversity and enzyme activity of ferric-chelate reductase LeFRO1 in tomato.

    PubMed

    Kong, Danyu; Chen, Chunlin; Wu, Huilan; Li, Ye; Li, Junming; Ling, Hong-Qing

    2013-11-20

    Ferric-chelate reductase which functions in the reduction of ferric to ferrous iron on root surface is a critical protein for iron homeostasis in strategy I plants. LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato. To identify the natural variations of LeFRO1 and to assess their effect on the ferric-chelate reductase activity, we cloned the coding sequences of LeFRO1 from 16 tomato varieties collected from different regions, and detected three types of LeFRO1 (LeFRO1(MM), LeFRO1(Ailsa) and LeFRO1(Monita)) with five amino acid variations at the positions 21, 24, 112, 195 and 582. Enzyme activity assay revealed that the three types of LeFRO1 possessed different ferric-chelate reductase activity (LeFRO1(Ailsa) > LeFRO1(MM) > LeFRO1(Monita)). The 112th amino acid residue Ala of LeFRO1 is critical for maintaining the high activity of ferric-chelate reductase, because modification of this amino acid resulted in a significant reduction of enzyme activity. Further, we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1. In conclusion, the findings are helpful to understand the natural adaptation mechanisms of plants to iron-limiting stress, and may provide new knowledge to select and manipulate LeFRO1 for improving the iron deficiency tolerance in tomato.

  8. SUS users' perception: a speech-language pathology approach based on health promotion.

    PubMed

    Cunha, Jenane Topanotti da; Massi, Giselle; Guarinello, Ana Cristina; Pereira, Francine Martins

    2016-01-01

    This study aimed to analyze the perceptions of users of the Brazilian Unified Health System (SUS) about the treatment Center where they were assisted, as well as about the speech-language pathology services rendered by this Center. This is a transversal study composed of an interview with 26 open questions and 14 closed questions applied to 111 individuals who were assisted at the SUS Center in August 2013. The quantitative content analysis was conducted through the use of the GraphPadPrisma 5.1, Statistic Package for Social Sciences (SPSS) 15.0 software and the application of the D'agostino & Person, F-test and chi-squared test. Most participants reported a positive perception about the facilities and staff of the treatment center. They were also positive about the waiting time and the speech-language pathologists' explanations and conduct, especially in the audiology department. Most responses from participants were short and did not present an argumentative context. The treatment center received a high approval rating by most users. The audiology department had better grades than the clinical services related to language and oral motor pathologies.

  9. Comparison of two codon optimization strategies enhancing recombinant Sus scrofa lysozyme production in Pichia pastoris.

    PubMed

    Zhu, D; Cai, G; Wu, D; Lu, J

    2015-05-16

    Lysozyme has played an important role in animal feed additive industry, food additive industry and biological engineering. For improving expression efficiency of recombinant lysozyme from Sus scrofa, two genes respectively designed by the most used codon optimization strategies, "one amino acid one codon" and "codon randomization", were synthesized and expressed in Pichia pastoris X—33. At shaking flask level, Sus scrofa lysozyme (SSL) under two conditions had a highest activity of 153.33±10.41 and 538.33±15.18 U/mL after a 5 days induction of 1% methanol, with secreted protein concentration 80.03±1.94 and 239.60±4.16 mg/L, respectively. Compared with the original SSL gene, the expression of optimized SSL gene by the second strategy showed a 2.6 fold higher level, while the first method had no obvious improvement in production. In total secreted protein, the proportions of recombinant SSL encoded by the original gene, first method optimized gene and the second—strategy optimized one were 75.06±0.25%, 74.56±0.14% and 79.00±0.14%, respectively, with the same molecular weight about 18 kDa, optimum acidity pH 6.0 and optimum temperature 35degC.

  10. Cryptosporidium suis and Cryptosporidium scrofarum in Eurasian wild boars (Sus scrofa) in Central Europe.

    PubMed

    Němejc, Karel; Sak, Bohumil; Květoňová, Dana; Hanzal, Vladimír; Janiszewski, Paweł; Forejtek, Pavel; Rajský, Dušan; Ravaszová, Petra; McEvoy, John; Kváč, Martin

    2013-11-08

    From 2011 to 2012, to identify Cryptosporidium spp. occurrence in Eurasian wild boars (Sus scrofa) 29 randomly selected localities (both forest areas and enclosures) across the Central European countries of Austria, the Czech Republic, Poland, and the Slovak Republic were investigated. Cryptosporidium oocysts were microscopicaly detected in 11 out of 460 faecal samples examined using aniline-carbol-methyl violet staining. Sixty-one Cryptosporidium infections, including the 11 infections that were detected by microscopy, were detected using genus- or species-specific nested PCR amplification of SSU rDNA. This represents a 5.5 fold greater sensitivity for PCR relative to microscopy. Combining genus- and species-specific PCR tools significantly changes the perspective on the occurrence of Cryptosporidium spp. in wild boars. While RFLP and direct sequencing of genus specific PCR-amplified products revealed 56 C. suis (20) and C. scrofarum (36) monoinfections and only 5 mixed infections of these species, species-specific molecular tools showed 44 monoinfections and 17 mixed infections with these species. PCR analysis of the gp60 gene did not reveal any other Cryptosporidium infections. Similar to domestic pigs, C. scrofarum was detected as a dominant species infecting adult Eurasian wild boars (Sus scrofa). Cryptosporidium infected wild boars did not show signs of clinical disease. This report is perhaps the most comprehensive survey of cryptosporidial infection in wild boars.

  11. The Use of Genomics in Conservation Management of the Endangered Visayan Warty Pig (Sus cebifrons)

    PubMed Central

    Bosse, Mirte; Crooijmans, Richard P. M. A.; Madsen, Ole; Schaftenaar, Willem; Ryder, Oliver A.; Megens, Hendrik-Jan

    2016-01-01

    The list of threatened and endangered species is growing rapidly, due to various anthropogenic causes. Many endangered species are present in captivity and actively managed in breeding programs in which often little is known about the founder individuals. Recent developments in genetic research techniques have made it possible to sequence and study whole genomes. In this study we used the critically endangered Visayan warty pig (Sus cebifrons) as a case study to test the use of genomic information as a tool in conservation management. Two captive populations of S. cebifrons exist, which originated from two different Philippine islands. We found some evidence for a recent split between the two island populations; however all individuals that were sequenced show a similar demographic history. Evidence for both past and recent inbreeding indicated that the founders were at least to some extent related. Together with this, the low level of nucleotide diversity compared to other Sus species potentially poses a threat to the viability of the captive populations. In conclusion, genomic techniques answered some important questions about this critically endangered mammal and can be a valuable toolset to inform future conservation management in other species as well. PMID:27069913

  12. [Supply and demand of the medium-complexity/SUS: relation with primary health care].

    PubMed

    Pires, Maria Raquel Gomes Maia; Göttems, Leila Bernarda Donato; Martins, Cristiano Mundim Ferreira; Guilhem, Dirce; Alves, Elioenai Dornelles

    2010-06-01

    This work aims at investigating the supply and demand of the medium-complexity services from the Federal District and surrounding municipalities from the state of Goiás. Our hypothesis is that the services organization offer of primary care (PC) from the Federal District (DF) and its surroundings overloads the medium-complexity services (MC), contributing to less equity in terms of communities access. Our objective is to analyze the demand for MC (medium-complexity) services in DF (Federal District) and its relation with PC (Primary Care); to quantify the origin, health problem, reason, transportation time and performed procedures of the ones who go to the Federal District hospitals; to set up priorities of managerial changes in the Brazilian Health System (SUS) in order to have more access to users. The evaluation was triangulation of methods, and complementing qualitative and quantitative approaches. The study of the offer via the analysis of SUS information systems, and the demand through a survey with 1,585 users of seven hospitals of the Federal District. There is a sub utilization of services offer at the Federal District, with duplicity of basic actions among hospitals and other health centers. It is recommended a revision in the health services regionalization and hierarchy of the Federal District and Goiás, as well as more investments on implementation of technology to primary care.

  13. Pig-mentation: postmortem iris color change in the eyes of Sus scrofa.

    PubMed

    Abraham, Elizabeth; Cox, Margaret; Quincey, David

    2008-05-01

    Experienced forensic pathologists and examiners may be familiar with the phenomenon of postmortem iris color change; however, only Knight, Simpson's forensic medicine, Arnold, London, 1997; Ref. 1 and Saukko and Knight, Knight's forensic pathology, 3rd ed., Arnold, London, 2004; Ref. 2 have referred to it in the literature, and to date, there have been no published scientific research studies on this taphonomic artifact. A controlled experiment was conducted of postmortem changes to isolated Sus scrofa eyes. The eyes (n = 137) were separated into three groups and each sample was observed for 3-day postmortem at a different temperature. In addition, a Sus scrofa head was obtained to observe postmortem changes of eyes in situ. All isolated blue eyes in the experiment, at room temperature and higher, changed to brown/black within 48 h. The in situ blue eye, at room temperature, turned brown/black within 72 h. If iris color consistently changes postmortem in humans, then this taphonomic artifact must be incorporated into victim identification protocol, including disaster victim identification software, and autopsy reports to prevent inaccurate victim identification and inappropriate exclusion from the identification process.

  14. [SUS management and monitoring and evaluation practices: possibilities and challenges for building a strategic agenda].

    PubMed

    Carvalho, André Luis Bonifácio de; Souza, Maria de Fátima; Shimizu, Helena Eri; Senra, Isabel Maria Vilas Boas; Oliveira, Kátia Cristina de

    2012-04-01

    This paper deals with the challenges involved in institutionalizing Monitoring and Evaluation practices within the scope of management of the Brazilian Unified Health System (SUS), based on the creation of a strategic agenda. This is structured around actions by the Federal Administration, from the perspective of defining the scope of the federative relationship. A summarized literature review is thus presented, placing into context the current SUS management process, which is based on the Pact for Health as well as theoretical and operational aspects inherent to monitoring and evaluation practices. The approach related to the strategic agenda highlights the creation of mechanisms that underpin the political and institutional decision, namely the creation of financial incentives and the development of technical mechanisms. These include organizational strategies for qualifying management teams and conducting studies and research and the dissemination of strategic information. These processes are based on the concept of providing for the management specificities in the different spheres of management based on a broad cooperation process involving teaching and research institutions and international organizations as well as the managers themselves.

  15. The Use of Genomics in Conservation Management of the Endangered Visayan Warty Pig (Sus cebifrons).

    PubMed

    Nuijten, Rascha J M; Bosse, Mirte; Crooijmans, Richard P M A; Madsen, Ole; Schaftenaar, Willem; Ryder, Oliver A; Groenen, Martien A M; Megens, Hendrik-Jan

    2016-01-01

    The list of threatened and endangered species is growing rapidly, due to various anthropogenic causes. Many endangered species are present in captivity and actively managed in breeding programs in which often little is known about the founder individuals. Recent developments in genetic research techniques have made it possible to sequence and study whole genomes. In this study we used the critically endangered Visayan warty pig (Sus cebifrons) as a case study to test the use of genomic information as a tool in conservation management. Two captive populations of S. cebifrons exist, which originated from two different Philippine islands. We found some evidence for a recent split between the two island populations; however all individuals that were sequenced show a similar demographic history. Evidence for both past and recent inbreeding indicated that the founders were at least to some extent related. Together with this, the low level of nucleotide diversity compared to other Sus species potentially poses a threat to the viability of the captive populations. In conclusion, genomic techniques answered some important questions about this critically endangered mammal and can be a valuable toolset to inform future conservation management in other species as well.

  16. Nutrition chez le brûlé

    PubMed Central

    Perro, G.

    2016-01-01

    Summary La nutrition est un challenge chez le brûlé, paradigme de l’agressé. Les points importants sont les apports entéraux précoces par sonde gastrique voire post pyloriques, la position proclive > 30°, la surveillance du transit et sa régulation par gastro ou entéro-kinétiques, la surveillance du poids, la quantification des apports avec supplémentation parentérale en cas de retard protéino énergétique. Chez l’enfant, l’adhésion à l’alimentation est difficile, de même que chez le senior, où une évaluation nutritionnelle initiale dépiste souvent une dénutrition préexistante. Les compléments alimentaires seront largement prescrits chez les patients de gravité intermédiaire. Les obèses bénéficieront d’un régime hypocalorique et hyperprotidique. Chez l’insuffisant rénal non dialysé il convient de limiter les apports en potassium. En cas brûlure périnéale, on peut proposer soit une constipation de courte durée, soit la mise en place d’un entéro-collecteur, les indications de colostomie étant devenues rares. Les apports entéraux sont difficiles à gérer en cas de décubitus ventral pour SDRA. Chez le brûlé grave de réanimation, l’accent doit plus être mis sur la qualité des nutriments que sur leur quantité. Les anciennes formules d’estimation calorique conduisaient à une surnutrition difficile à administrer et en général mal tolérée; la quantification mesurée par calorimétrie indirecte ou estimée par la formule de Toronto est bien plus adaptée. Plus récemment, l’instauration d’une immunonutrition (supplémentation en vitamines et oligo-éléments, glutamine, arginine, acide Ω 3 et contrôle raisonné de la glycémie) a été proposée pour réduire le stress oxydatif et l’inflammation provoqués par l’accident. PMID:27857647

  17. Le tetanos chez le grand enfant dans un hôpital pédiatrique à Yaoundé, Cameroun

    PubMed Central

    Ntoto Njiki Kinkela, Mina; Nguefack, Félicitée; Mbassi Awa, Hubert; Chelo, David; Enyama, Dominique; Mbollo Kobela, Marie; Koki Ndombo, Paul Olivier

    2012-01-01

    Le tétanos est évitable par la vaccination, mais peut survenir en cas d'une immunisation incomplète. Nous avons mené une étude sur les dossiers médicaux des enfants admis pour tétanos entre 2008-2009 au Centre Mère et Enfant de la Fondation Chantal BIYA à Yaoundé. Le but était d'analyser les circonstances de survenue et les manifestations cliniques du tétanos chez le grand enfant, afin de proposer des stratégies de prévention adaptées au contexte camerounais. Le statut vaccinal était inconnu chez un patient, les autres (80%) n'avaient pas reçu de rappel vaccinal. Les portes d'entrée étaient les plaies aux membres, l'une était secondaire à une injection médicamenteuse. Tous ont présenté le tétanos généralisé. Le décès était survenu chez un patient. Le tétanos n'est pas rare chez le grand enfant au Cameroun. Il se dégage ainsi la problématique des rappels vaccinaux. PMID:22514771

  18. Primary Attraction of Ips latidens (LeConte) and Hylastes Gracilis LeConte (Coleoptera: Scolytidae) to High-Girdled Lodgepole Pine, Pinus Contorta var. Latifolia Engelmann

    Treesearch

    D.R. Miller; J.L. Madden; J.H. Borden

    1986-01-01

    In the absence of secondary attraction, 2 species of Scolytidae, Ips latidens (LeConte) and Hylastes gracilis LeConte, showed significant preference while in flight for high-girdled over non-girdled lodgepole pines, Pinus contorta var. latifolia Engelmann. In contrast, beetles in 2 genera...

  19. Overexpression of GhSusA1 increases plant biomass and improves cotton fiber yield and quality.

    PubMed

    Jiang, Yanjie; Guo, Wangzhen; Zhu, Huayu; Ruan, Yong-Ling; Zhang, Tianzhen

    2012-04-01

    Cotton (Gossypium spp.) is an important economic crop and the largest source of textile fiber in the world. However, to date, only a few genes have been identified that exhibit critical roles in fiber development, and few has shown positive effects on fiber yield and quality in transgenic cotton. Here, we report the characterization of a novel sucrose synthase (SusA1) gene from a superior quality fiber germplasm line 7235 in Gossypium hirsutum. By association analysis, GhSusA1 was highly correlated with fiber qualities in (7235× TM-1) recombinant inbred lines based on polymorphism of GhSusA1 between 7235 and TM-1. Subsequently, based on an interspecific population of 141 BC₁ individuals generated from the cross between TM-1 and Gossypium barbadense line, Hai7124, we further mapped GhSusA1 genes on homeologous chromosomes A8 (chro.8) and D8 (chro.24). Suppression of GhSusA1 in transgenic cotton reduced fiber quality and decreased the boll size and seed weight. Importantly, overexpression of this gene increased fiber length and strength, with the latter indicated by the enhanced thickening of cell wall during secondary wall formation stage. Moreover, increasing GhSusA1 transcript abundance in vegetative tissues led to elevated seedling biomass. Together, these findings identified GhSusA1 as a key regulator of sink strength in cotton, which is tightly associated with productivity, and hence a promising candidate gene that can be developed to increase cotton fiber yield and quality.

  20. Le stéréorestituteur Kelsh

    USGS Publications Warehouse

    Kelsh, H.T.

    1949-01-01

    Le ste??re??orestituteur Kelsh est un appareil de restitution a?? double projection base?? sur le principe des anaglyphes, comme le Multiplex par exemple, mais il a une plus grande pre??cision que ce dernier, vu que les ne??gatifs sont utilise??s directement pour la restitution, sans que l'on soit oblige?? de les re??duire au pre??alable. Une telle solution devient possible lorsque l'e??chelle de l'image plastique (mode??le) est au moins 7 fois plus grande que celle des cliche??s. L'appareil comprend un support reposant par 4 pieds sur la table a?? dessin. Sa partie supe??rieure porte, par l'interme??diaire de trois vis calantes, un cadre dans lequel les deux chambres de projection sont suspendues. Des leviers de commande, agissant sur les chambres, permettent d'introduire la base, le de??versement et les inclinaisons transversale et longitudinale. Les cliche??s conjugue??s ou des diapositifs sont directement place??s dans les chambres de projection munies d'objectifs. En projetant les deux cliche??s au moyen de couleurs comple??mentaires, l'observateur - muni de lunettes a?? verres colore??s (couleurs comple??mentaires) - observe l'image plastique audessus de la table a?? dessin, l'orientation relative des chambres ayant e??te?? e??tablie au pre??alable. Pour le report des points de l'image plastique sur la minute, l'ope??rateur dispose d'une tablette amovible a?? marque-repe??re lumineuse qu'il de??place a?? la main et dont la hauteur au-dessus de la table a?? dessin peut e??tre commande??e par une molette. Pour e??tablir l'orientation absolue de l'image plastique, il suffit d'incliner convenablement le cadre de suspension a?? l'aide des vis calantes, l'orientation relative n'e??tant pas de??truite par cette ope??ration. Les deux cliche??s sont e??claire??s par des projecteurs munis d'une suspension a?? la cardan et relie??s a?? la tablette de restitution par des tiges te??lescopiques. Moyennant ce dispositif, l'e??clairage est concentre?? sur deux petites re

  1. Le médicament générique au Maroc: le point de vue du consommateur

    PubMed Central

    Zaoui, Sanaa; Hakkou, Farid; Filali, Houda; Khabal, Youssef; Tazi, Illias; Mahmal, Lahoucine

    2013-01-01

    Introduction Le médicament générique est souvent une origine de préjugés négatifs et de méfiance chez les professionnels de santé et les patients. Ceci pourrait être dû à plusieurs facteurs entre autre le manque des connaissances du patient sur ces médicaments. Le but de notre étude était d’évaluer l'information du consommateur sur les médicaments génériques et apprécier leur utilisation de ces médicaments. Méthodes Il s'agit d'une étude transversale réalisée de Janvier à Mars 2010 auprès de 251 sujets. Un questionnaire comprenant dix questions fermées a été utilisé. Les questions concernaient l’évaluation des connaissances sur les médicaments génériques, les sources d'information, le degré de confiance et d'information des patients sur ces médicaments. Une analyse descriptive simple des différentes variables a été réalisée. Résultats Dans notre étude, 126 sujets (50,2%) ont répondu connaître les médicaments génériques. Parmi eux, 52,3% les utilisaient et 67,4% estimaient qu'ils étaient insuffisamment informés sur ces médicaments. Les cadres supérieurs et les étudiants ont représenté la catégorie qui utilisait le plus les médicaments génériques (respectivement dans 40,9% et 25,7%) et qui était la mieux informée (respectivement dans 61,9% et 23,81%). Le faible coût a été la principale motivation d'utilisation du médicament générique (93,9%). Les médias ont représenté la première source d'information (59,5%). Après sensibilisation, 88,8% des sujets qui ne connaissaient pas le médicament générique ont été favorable à son utilisation. Conclusion Une promotion efficace par une politique d'information soutenue auprès des consommateurs et par des mesures incitatrices à la prescription et à la délivrance du générique par les médecins et les pharmaciens, pourront améliorer l'utilisation de ces médicaments dans notre pays. PMID:24009794

  2. Seroprevalence of Neospora caninum in feral swine (Sus scrofa) in the United States.

    PubMed

    Cerqueira-Cézar, Camila K; Pedersen, Kerri; Calero-Bernal, Rafael; Kwok, Oliver C; Villena, Isabelle; Dubey, Jitender P

    2016-08-15

    The protozoon Neospora caninum is a major cause of abortion in cattle worldwide. Canids (Canis familiaris, Canis latrans, Canis lupus) are definitive hosts whereas many other animal species, including pigs, are intermediate hosts for the parasite. Between 2012 and 2014, serum samples from 1059 feral swine (Sus scrofa) from 29 states of the USA were tested for N. caninum antibodies, using the N. caninum agglutination test (NAT). Of these, 159 (15.0%) feral pigs from 21 states tested positive, with a range of titers of 1:25 (cut-off) (n=153), 1:200 (1), 1:400 (1), 1:800 (3) and 1:3200 (1). Results indicate widespread exposure of feral swine to N. caninum infection across the USA.

  3. FATAL CASE OF STREPTOCOCCUS SUIS INFECTION IN A YOUNG WILD BOAR (SUS SCROFA) FROM SOUTHWESTERN SPAIN.

    PubMed

    Risco, David; Fernández-Llario, Pedro; Cuesta, Jesús M; García-Jiménez, Waldo L; Gonçalves, Pilar; Martínez, Remigio; García, Alfredo; Rosales, Rubén; Gómez, Luis; de Mendoza, Javier Hermoso

    2015-06-01

    Streptococcus suis is a recognized pathogen that may cause important diseases in pigs and humans. This microorganism has been repeatedly isolated from wild boar (Sus scrofa). However, its health implications for this wild species are still unknown. This article reports a detailed description of a fatal case of septicemia by S. suis affecting a young wild boar. The affected animal, about 15 days old, was found near death and exhibiting neurologic signs at a wild boar estate in southwestern Spain. Postmortem examination showed generalized congestion, brain hemorrhages and lobular pneumonia. Histopathological evaluation demonstrated the presence of meningitis and encephalitis with marked congestion and suppurative bronchopneumonia. Streptococcus suis serotype 2 isolates exhibiting important virulence factors (extracellular factor, muramidase-released protein, and suylisin) were isolated from the affected animal. This study confirms the presence of potentially virulent and zoonotic strains of S. suis in wild boar from Spain.

  4. Caries, Periodontal Disease, Supernumerary Teeth and Other Dental Disorders in Swedish Wild Boar (Sus scrofa).

    PubMed

    Malmsten, A; Dalin, A-M; Pettersson, A

    2015-07-01

    Between January and December 2013, the dental and periodontal health of 99 Swedish wild boars (Sus scrofa) was investigated. Sampling occurred in conjunction with routine hunting at six large estates in the southern and middle parts of Sweden. All six of the estates use supplemental feeding. The weight of the animals, their sex and their dates of death were noted. Age was estimated using tooth eruption and tooth replacement patterns. The oral cavity was inspected and abnormalities were recorded on a dental chart modified for wild boars. The findings included supernumerary teeth, absence of teeth, mild class II malocclusion, severe tooth wear, periodontitis, calculus, caries, tooth fractures and the presence of enamel defects. Swedish wild boars suffer from different dental lesions and the impact of supplemental feeding on dental and periodontal health is still to be investigated.

  5. Torque teno virus (TTV) is highly prevalent in the European wild boar (Sus scrofa).

    PubMed

    Martínez, Laura; Kekarainen, Tuija; Sibila, Marina; Ruiz-Fons, Francisco; Vidal, Dolors; Gortázar, Christian; Segalés, Joaquim

    2006-12-20

    The present study represents the first survey of Torque teno virus (TTV) prevalence in European wild boar (Sus scrofa). The prevalence of two distinct TTV genogroups in 178 Spanish wild boar sera from different geographic regions, management conditions, gender and age was determined by a nested PCR method. The overall prevalence of TTV genogroups was 84% (58% for genogroup 1 and 66% for genogroup 2), and differences between genogroup prevalence were observed depending on the geographical region analysed. Significantly higher prevalence for TTV genogroup 2 was found in fenced managed wild boar, juvenile animals and females. No other significant differences in TTV genogroup prevalence were observed. The phylogenetic analysis of nucleotide sequences obtained from the untranslated region of selected samples revealed that the same TTV genogroups are infecting wild boar and domestic pig. The results indicate that TTV is apparently ubiquitous in European wild boar populations.

  6. BANFISA and (IN) DICA-SUS in health undergraduate education: playing and learning construction.

    PubMed

    Silva, Laianna Victoria Santiago; Tanaka, Patrícia Sayuri de Lima; Pires, Maria Raquel Gomes Maia

    2015-01-01

    To analyze the learning built during the matches of the games by students of the subject Gestão de Políticas Públicas em Saúde at the Universidade de Brasília. Exploratory, descriptive research, in a qualitative approach, with 26 students from various graduation courses in health, using a questionnaire and participant observation. Participants reinvented rules, related issues addressed in the games to the reality, interacted with colleagues and had fun throughout the match. Comparing the games in relation to ludicity, the BANFISA was more attractive than the (IN) DICA-SUS, although they are complementary. Learning constructed by the students goes beyond the content of the subject; involve the active participation in group and creativity.

  7. The Effect of Clothing on the Rate of Decomposition and Diptera Colonization on Sus scrofa Carcasses.

    PubMed

    Card, Allison; Cross, Peter; Moffatt, Colin; Simmons, Tal

    2015-07-01

    Twenty Sus scrofa carcasses were used to study the effect the presence of clothing had on decomposition rate and colonization locations of Diptera species; 10 unclothed control carcasses were compared to 10 clothed experimental carcasses over 58 days. Data collection occurred at regular accumulated degree day intervals; the level of decomposition as Total Body Score (TBSsurf ), pattern of decomposition, and Diptera present was documented. Results indicated a statistically significant difference in the rate of decomposition, (t427  = 2.59, p = 0.010), with unclothed carcasses decomposing faster than clothed carcasses. However, the overall decomposition rates from each carcass group are too similar to separate when applying a 95% CI, which means that, although statistically significant, from a practical forensic point of view they are not sufficiently dissimilar as to warrant the application of different formulae to estimate the postmortem interval. Further results demonstrated clothing provided blow flies with additional colonization locations.

  8. Lead and cadmium in wild boar (Sus scrofa) in the Sierra Nevada Natural Space (southern Spain).

    PubMed

    Mulero, Rocío; Cano-Manuel, Javier; Ráez-Bravo, Arián; Pérez, Jesús M; Espinosa, José; Soriguer, Ramón; Fandos, Paulino; Granados, José E; Romero, Diego

    2016-08-01

    The aims of the present study were to investigate Pb and Cd levels in tissues of wild boar (Sus scrofa) from the Sierra Nevada Natural Space (SNNS) (southern Spain). Heavy metal concentrations in livers, kidneys and bones from 111 animals were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Bones and kidneys were the most Pb- and Cd-contaminated tissues, respectively; Cd concentrations were 5.6 times higher in kidneys than in livers. This is the first biomonitoring study of these pollutants in wild boar tissues in the SNNS, and findings indicate that this population is chronically exposed to these heavy metals. The detected Pb and Cd concentrations were lower than those found in many studies performed in Europe on the same species.

  9. High prevalence of hepatitis E virus in wild boar (Sus scrofa) in Yamaguchi Prefecture, Japan.

    PubMed

    Hara, Yuka; Terada, Yutaka; Yonemitsu, Kenzo; Shimoda, Hiroshi; Noguchi, Keita; Suzuki, Kazuo; Maeda, Ken

    2014-04-01

    Hepatitis E virus (HEV) causes a food- and water-borne disease in humans, and Japanese wild boar (Sus scrofa leucomystax) meat is one of the most important sources of infection in Japan. We tested 113 serum samples from wild boar captured in Shimonoseki City, Yamaguchi Prefecture, Japan from 2010 to 2012. Serum samples were tested by enzyme-linked immunosorbent assay (ELISA) using virus-like particles as antigen and nested reverse-transcription PCR (RT-PCR). Anti-HEV IgG antibodies were detected in 47 of the 113 wild boar serum samples (42%), and HEV RNA was detected in five samples (4%). Sequence analysis showed that the five HEV isolates belonged to genotype 4, forming a cluster with a previous isolate from a human hepatitis E case in this region in 2011. These results indicate that wild boar in this region are infected with potentially pathogenic HEV at a high prevalence.

  10. Congenital toxoplasmosis in wild boar (Sus scrofa) and identification of the Toxoplasma gondii types involved.

    PubMed

    Calero-Bernal, Rafael; Gómez-Gordo, Luis; Saugar, José María; Frontera, Eva; Pérez-Martín, Juan Enrique; Reina, David; Serrano, Francisco Javier; Fuentes, Isabel

    2013-10-01

    Congenital toxoplasmosis has been little described in wild animals. We report a case of vertical transmission in wild boar (Sus scrofa). Necropsy and histopathologic examination of a pregnant female and her three fetuses revealed all to have lesions compatible with acute toxoplasmosis. Nested polymerase chain reaction B1 gene detected Toxoplasma gondii in maternal (heart and diaphragm) and fetal (central nervous system, retina, optic nerve, heart, lung, tongue, and diaphragm) samples. The mother had a mixed infection of T. gondii types I and III. One fetus with type III infection developed no malformations, but the others-one with type I infection and one infected by types I and III-showed bilateral ocular agenesis, prognathism, and agenesis of the nasal cartilage. These results suggest the pathogenicity of the various T. gondii types may differ in wild boars.

  11. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    PubMed

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution.

  12. Surface Alloying of SUS 321 Chromium-Nickel Steel by an Electron-Plasma Process

    NASA Astrophysics Data System (ADS)

    Ivanov, Yu. F.; Teresov, A. D.; Petrikova, E. A.; Krysina, O. V.; Ivanova, O. V.; Shugurov, V. V.; Moskvin, P. V.

    2017-07-01

    The mechanisms of forming nanostructured, nanophase layers are revealed and analyzed in austenitic steel subjected to surface alloying using an electron-plasma process. Nanostructured, nanophase layers up to 30 μm in thickness were formed by melting of the film/substrate system with an electron beam generated by a SOLO facility (Institute of High Current Electronics, SB RAS), Tomsk), which ensured crystallization and subsequent quenching at the cooling rates within the range 105-108 K/s. The surface was modified with structural stainless steel specimens (SUS 321 steel). The film/substrate system (film thickness 0.5 μm) was formed by a plasma-assisted vacuum-arc process by evaporating a cathode made from a sintered pseudoalloy of the following composition: Zr - 6 at.% Ti - 6 at.% Cu. The film deposition was performed in a QUINTA facility equipped with a PINK hot-cathode plasma source and DI-100 arc evaporators with accelerated cooling of the process cathode, which allowed reducing the size and fraction of the droplet phase in the deposited film. It is found that melting of the film/substrate system (Zr-Ti-Cu)/(SUS 321 steel) using a high-intensity pulsed electron beam followed by the high-rate crystallization is accompanied by the formation of α-iron cellular crystallization structure and precipitation of Cr2Zr, Cr3C2 and TiC particles on the cell boundaries, which as a whole allowed increasing microhardness by a factor of 1.3, Young's modulus - by a factor of 1.2, wear resistance - by a factor of 2.7, while achieving a three-fold reduction in the friction coefficient.

  13. Analysis of Bos taurus and Sus scrofa X and Y chromosome transcriptome highlights reproductive driver genes.

    PubMed

    Khan, Faheem Ahmed; Liu, Hui; Zhou, Hao; Wang, Kai; Qamar, Muhammad Tahir Ul; Pandupuspitasari, Nuruliarizki Shinta; Shujun, Zhang

    2017-08-15

    The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively. The consensus module calculation yields an overall 167 overlapped genes which were mapped to 846 DEGs in Bos taurus to finally get a list of 67 dual feature genes. We develop gene co-expression network of selected 67 genes that consists of 58 nodes (27 down-regulated and 31 up-regulated genes) enriched to 66 GO biological process (BP) including 6 GO annotations related to reproduction and two KEGG pathways. Moreover, we searched significantly related TF (ISRE, AP1FJ, RP58, CREL) and miRNAs (bta-miR-181a, bta-miR-17-5p, bta-miR-146b, bta-miR-146a) which targeted the genes in co-expression network. In addition we performed genetic analysis including phylogenetic, functional domain identification, epigenetic modifications, mutation analysis of the most important reproductive driver genes PRM1, PPP2R2B and PAFAH1B1 and finally performed a protein docking analysis to visualize their therapeutic and gene expression regulation ability.

  14. Analysis of Bos taurus and Sus scrofa X and Y chromosome transcriptome highlights reproductive driver genes

    PubMed Central

    Khan, Faheem Ahmed; Liu, Hui; Zhou, Hao; Wang, Kai; Qamar, Muhammad Tahir Ul; Pandupuspitasari, Nuruliarizki Shinta; Shujun, Zhang

    2017-01-01

    The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively. The consensus module calculation yields an overall 167 overlapped genes which were mapped to 846 DEGs in Bos taurus to finally get a list of 67 dual feature genes. We develop gene co-expression network of selected 67 genes that consists of 58 nodes (27 down-regulated and 31 up-regulated genes) enriched to 66 GO biological process (BP) including 6 GO annotations related to reproduction and two KEGG pathways. Moreover, we searched significantly related TF (ISRE, AP1FJ, RP58, CREL) and miRNAs (bta-miR-181a, bta-miR-17-5p, bta-miR-146b, bta-miR-146a) which targeted the genes in co-expression network. In addition we performed genetic analysis including phylogenetic, functional domain identification, epigenetic modifications, mutation analysis of the most important reproductive driver genes PRM1, PPP2R2B and PAFAH1B1 and finally performed a protein docking analysis to visualize their therapeutic and gene expression regulation ability. PMID:28903352

  15. Snow in Castile-León: trends and variability

    NASA Astrophysics Data System (ADS)

    Merino, A.; Campos, L.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The location of Castile and León, inside the Iberian Peninsula, in the Northwestern quadrant, determines, in large measure, the climatic conditions of its territory, granting it very characteristic traits, mostly in the mountainous areas. It is important to note that during a large part of the year, the region is under the influence of Jet Stream, and thus, gives way to very diverse dynamic situations, which turn into different and heterogeneous types of weather. So, in many areas of the region, especially in the most elevated areas, these synoptic and mesoscale situations generate snow precipitation. We should point out that snowfall is one of the principal meteorological risks of Castile and León. Thus, on average, in some mountainous areas there are more than 40 events of snowfall registered annually, with the month of January being the month in which the highest frequency of snowfall appears. The social repercussions of this snowfall are represented in the isolation of places, essentially mountainous, highways being blocked, increase in traffic accidents, etc. As proof of this, it is this type of episode that receives ample coverage by the media, which has a linear relationship with the social perception of risk. As such, the objective of the current work is to analyze the annual trend of days with snow in the different meteorological stations pertaining to AEMET placed in the Community. The period of study is from 1960-2010. Additionally, we have also evaluated trends in annual days of freezing temperature and annual absolute minimum temperature, with the objective of facilitating a meteorological interpretation of the trends obtained on days with snowfall. Finally, the results show that in the majority of stations, a significant negative trend in days with snowfall and annual days with freezing temperatures, and a positive trend in annual absolute minimum temperatures. However, we observed variability in the different regions in the area of study

  16. Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

    PubMed Central

    Bakolitsa, Constantina; Xu, Qingping; Rife, Christopher L.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chen, Connie; Chiu, Hsiu-Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Farr, Carol L.; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Anna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Krishna, S. Sri; Kumar, Abhinav; Lam, Winnie W.; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Puckett, Christina; Reyes, Ron; Tien, Henry J.; Trame, Christine B.; van den Bedem, Henry; Weekes, Dana; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2010-01-01

    The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex. PMID:20944222

  17. Stratégie de traitement : Rôle de l’enfuvirtide dans la prise en charge des effets secondaires limitant le traitement

    PubMed Central

    Tsoukas, Christos

    2007-01-01

    Les effets secondaires peuvent limiter les options s’offrant aux médecins dans le traitement de l’infection par le VIH. La prise en charge de ces effets secondaires est essentielle afin d’éviter l’arrêt du traitement. L’enfuvirtide, un inhibiteur de la fusion du VIH, peut être utile en tant qu’un des trois agents actifs du traitement antirétroviral. Ce peut être une façon de réduire les effets secondaires limitant le traitement et d’avoir un agent efficace pour le contrôle viral. Dans le cas présent, le patient avait des antécédents de traitements longs et problématiques, avec de nombreuses affections concomitantes. Son dernier schéma thérapeutique en date, qui comprend un agent d’une nouvelle classe thérapeutique, l’enfuvirtide, a maintenu la suppression du VIH tout en minimisant la toxicité.

  18. The rôle of planetaria: The Library of Alexandria Planetarium Science Center

    NASA Astrophysics Data System (ADS)

    El-Mitaky, Hoda S.

    2011-06-01

    In ancient times the stars and the Moon were humans' only guide to cross the seas and explore the depths of the deserts. With the use of modern technological gadgets, and the increasingly light pollution, citizens of the world stopped looking at the heavens. How can planetaria play a rôle in reviving public interest in astronomy? How can the beauty of astronomy play a rôle in luring the youth to pursue a career in science? How can astronomy play a rôle in raising public awareness about preserving the environment? Moreover, how can astronomy play a rôle in the dialogue among civilisations?

  19. Le consentement libre et éclairé aux soins en psychiatrie

    PubMed Central

    Neilson, Grainne; Chaimowitz, Gary

    2015-01-01

    Résumé Le patient a le droit d’être informé sur les soins de santé qui lui sont proposés et de participer activement à la prise de décisions relativement à ces soins. Le respect de la dignité et de l’autonomie de la personne passe par le respect de son droit de prendre des décisions à propos de ses soins psychiatriques, notamment de refuser un traitement, pour autant qu’elle soit apte à prendre des décisions. Il importe que le psychiatre connaisse les fondements éthiques du consentement libre et éclairé et les exigences prévues par le droit en cette matière, y compris la jurisprudence. Le consentement n’est pas immuable, pouvant changer avec le temps, au fil de l’évolution des conditions et des circonstances. Par conséquent, le consentement doit être un processus continu.

  20. Le gingembre contre la nausée et les vomissements de la grossesse

    PubMed Central

    Lindblad, Adrienne J.; Koppula, Sudha

    2016-01-01

    Question clinique Le gingembre peut-il traiter la nausée et les vomissements de la grossesse? Résultats Durant le premier trimestre, le gingembre soulagerait la nausée et les vomissements de quelque 4 points sur une échelle de 40 points, ou éliminerait les vomissements chez 1 femme sur 3 au jour 6. L’étude la plus vaste ne laisse croire à aucune hausse des malformations congénitales ou de la mortinatalité, mais les études de moins grande envergure laissent croire le contraire.

  1. Cross-Reactivity of Porcine Immunoglobulin A Antibodies with Fecal Immunoglobulins of Wild Boar (Sus scrofa) and Other Animal Species.

    PubMed

    Seo, Sang Won; Yoo, Sung J; Sunwoo, Sunyoung; Hyun, Bang Hun; Lyoo, Young S

    2016-06-01

    Fecal samples obtained from wild boar habitats are useful for the surveillance of diseases in wild boar populations; however, it is difficult to determine the species of origin of feces collected in natural habitats. In this study, a fecal IgA ELISA was evaluated as a method for identifying the porcine species from fecal samples. Both domestic pigs (Sus scrofa domestica) and wild boars (Sus scrofa coreanus) showed significantly higher levels of fecal IgA than other animal species. Additionally, age dependent changes in the level of Ig A in wild boars and domestic pigs were identified; Titers of Ig A were highest in suckling period and lowest in weanling period.

  2. Le genre Tunga Jarocki, 1838 (Siphonaptera : Tungidae). I – Taxonomie, phylogénie, écologie, rôle pathogène

    PubMed Central

    Beaucournu, J.-C.; Degeilh, B.; Mergey, T.; Muñoz-Leal, S.; González-Acuña, D.

    2012-01-01

    Pour la première fois, les 12 espèces actuellement décrites dans le genre Tunga sont étudiées sur le plan de la taxonomie et de la répartition. Divers aspects de leur biologie et leur rôle pathogène sont également envisagés, et en particulier leur phylogénie, leur chorologie, leur phénologie, leur sexe-ratio et leurs dermecos. PMID:23193514

  3. Repenser ensemble le concept d'autonomie alimentaire.

    PubMed

    Bélisle, Micheline; Labarthe, Jenni; Moreau, Cynthia; Landry, Elise; Adam, Gracia; Bourque Bouliane, Mijanou; Dupéré, Sophie

    2017-03-01

    C'est au cœur du projet de recherche-action participative « Vers une autonomie alimentaire pour tou-te-s : agir et vivre ensemble le changement » (VAATAVEC) que s'est élaborée une définition nouvelle et évolutive de l'autonomie alimentaire. De ce projet regroupant des personnes en situation de pauvreté, chercheurs et intervenants, a émergé une conceptualisation résultant à la fois d'une méthode de réflexion collective et d'un processus d'analyse collective, inspiré de la théorisation ancrée et de l'analyse conceptualisante de Paillé et Mucchielli (2003). Le recours à l'expertise des personnes en situation de pauvreté, expertes du vécu de l'insécurité alimentaire, a contribué à ancrer cette définition dans les causes structurelles de l'insécurité alimentaire dans une perspective de développement d'un pouvoir d'agir collectif, de toutes les personnes concernées. Il en résulte une définition de l'autonomie alimentaire d'où ressort une contribution surtout méthodologique et théorique.

  4. Magnetic study of the Ca{sub 1-x}Eu{sub x}MnO{sub 3} (O {le} x {le} 1) perovskites

    SciTech Connect

    Troyanchuk, I.O.; Samsonenko, N.V.; Szymczak, H.; Nabialek, A.

    1997-06-01

    The magnetization and crystal structure of Ca{sub 1-x}EuMnO{sub 3} (0 {le} x {le} 1) perovskites have been studied. It is shown that these compounds present four concentration regions in which different magnetic phases coexist. The antiferromagnetic phase is associated with a regular arrangement of Mn{sup 3+} and Mn{sup 4+} ions in ratios 1:3 and 1:1. The ferromagnetic phase is attributed to the charge disordered states and is found in 0 {le} x {le} 0.2 and 0.6 < x < 1 concentration ranges. The samples 0.1 < x < 0.2 show metamagnetic behavior which might result from the collapse of the charge ordered state (1:3). The CaMnO{sub 2.94} and EuMnO{sub 3.02} are weak ferromagnets with T{sub N} = 122 and 40 K, respectively.

  5. Do changes in soil properties after rooting by wild boars (Sus scrofa) affect understory vegetation in Swiss hardwood forests?

    Treesearch

    Sven Wirthner; Martin Schutz; Deborah S. Page-Dumroese; Matt D. Busse; James W. Kirchner; Anita C. Risch

    2012-01-01

    Recovering from small fragmented populations, wild boars (Sus scrofa L.) have considerably increased their numbers and their habitat range in many European countries during the past two decades. Although several studies have focused on the impact of wild boar rooting on selected vegetation properties, little is known about effects on entire forest ecosystems. The main...

  6. An Analysis of Recent Enrollment, Discipline and Graduation Trends among Females and Underrepresented Minorities at SUS Institutions

    ERIC Educational Resources Information Center

    Micceri, Theodore; Borman, Kathy

    2006-01-01

    Increased numbers of minority students as well as increased numbers of Florida high school graduates entering higher education in Florida have influenced Florida SUS [State University System] enrollment and graduation characteristics. This study of 510,952 undergraduate students shows that between the years 1996 and 2003, the number of entering…

  7. CoLeMo: A Collaborative Learning Environment for UML Modelling

    ERIC Educational Resources Information Center

    Chen, Weiqin; Pedersen, Roger Heggernes; Pettersen, Oystein

    2006-01-01

    This paper presents the design, implementation, and evaluation of a distributed collaborative UML modelling environment, CoLeMo. CoLeMo is designed for students studying UML modelling. It can also be used as a platform for collaborative design of software. We conducted formative evaluations and a summative evaluation to improve the environment and…

  8. LeY oligosaccharide upregulates DAG/PKC signaling pathway in the human endometrial cells.

    PubMed

    Li, Yali; Ma, Keli; Sun, Ping; Liu, Shuai; Qin, Huamin; Zhu, Zhengmei; Wang, Xiaoqi; Yan, Qiu

    2009-11-01

    LeY oligosaccharide is stage specifically expressed by the embryo and uterine endometrium, and it plays important roles in embryo implantation. In addition to participating in the recognition and adhesion on fetal-maternal interface, LeY potentially regulates the expression of some implantation-related factors. However, it remains elusive whether it can mediate the involved signaling pathway. In this study, agarose-LeY beads were used to mimic the embryos, and the effects of LeY oligosaccharide on DAG/PKC signaling pathway was studied in human endometrial epithelial cells. Results showed that LeY could significantly trigger the activation of cPKCalpha and cPKCbeta2, and their translocation from the cytosol to the plasma membrane. The cellular DAG content was also upregulated, and the activation of PLCgamma1 was promoted. On the contrary, DAG/PKC signaling pathway was significantly inhibited when anti-LeY antibody was used after confirmation of LeY expression in human endometrial epithelial cells by immunohistochemistry and flow cytometry. These results suggest that LeY oligosaccharide acts as a signal molecule to modulate DAG/PKC signaling pathway.

  9. Use of Mobile Testing System PeLe for Developing Language Skills

    ERIC Educational Resources Information Center

    Titova, Svetlana

    2015-01-01

    One of the objectives of this paper is to investigate the pedagogical impact of both the mobile testing system PeLe (Norway, HiST) and the enquiry-based learning approach on language skills development in the context of mobile-assisted learning. The research aims to work out a methodological framework of PeLe implementation into the language…

  10. CoLeMo: A Collaborative Learning Environment for UML Modelling

    ERIC Educational Resources Information Center

    Chen, Weiqin; Pedersen, Roger Heggernes; Pettersen, Oystein

    2006-01-01

    This paper presents the design, implementation, and evaluation of a distributed collaborative UML modelling environment, CoLeMo. CoLeMo is designed for students studying UML modelling. It can also be used as a platform for collaborative design of software. We conducted formative evaluations and a summative evaluation to improve the environment and…

  11. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  12. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  13. Identification and sequencing of remnant messenger RNAs found in domestic swine (Sus scrofa) fresh ejaculated spermatozoa.

    PubMed

    Yang, C C; Lin, Y S; Hsu, C C; Wu, S C; Lin, E C; Cheng, W T K

    2009-07-01

    The existence of specific messenger RNA remnants contained within freshly ejaculated spermatozoa was described in several species. Those investigations, using high-throughput techniques to screen the population of transcripts in ejaculated spermatozoa, were limited to the probes which mostly derived from nucleic acids of testicular tissues of either human or mice. The objective of this study was to investigate mRNA remnants from ejaculated spermatozoa of the domestic swine (Sus scrofa), a valuable model for biomedical research. A non-redundant 5'-end complementary DNA library was generated from swine ejaculated spermatozoa. After sequence quality verification, 4562 clones remained. These clones were then clustered and assembled into 514 unique sequences including 188 contigs (36.58%) and 326 singletons (63.42%), representing those clusters containing at least two clones and those clusters without having enough similarity with other clones. These unique gene sequences were annotated in Gene Ontology (GO) hierarchy; they included biological processes (38.7%), molecular functions (39.1%) and cellular components (40.3%). Based on the analysis, a broad spectrum of messenger RNAs existed in swine ejaculated spermatozoa and was closely correlated with nucleic acid binding, structural modifications, and transcriptional regulation. All of these categories are considered to have profound effects on the male reproductive system. Therefore, our work provides initial results on potential spermatozoal gene expression for future studies regarding the tightly regulated spermiogenic processes and later fertilization events.

  14. Detection of Torque Teno Sus Virus in Pork Bile and Liver Sausages.

    PubMed

    Monini, Marina; Vignolo, Edoardo; Ianiro, Giovanni; Ostanello, Fabio; Ruggeri, Franco Maria; Di Bartolo, Ilaria

    2016-12-01

    Torque teno viruses (TTV) are small DNA viruses widespread among humans and pigs. The clinical significance of TTV infections in either humans or pigs is uncertain. In fact, TTV viremia is highly prevalent in patients with different pathologies, but it can also be frequently observed in healthy subjects. Virus infection in pigs is considered a putative cofactor in several diseases; despite being detected frequently in healthy animals, its role still remains unknown. The present study aimed to investigate the presence of Torque teno sus virus (TTSuV) in 62 bile samples collected from pigs at slaughterhouse and in 36 fresh pork liver sausages bought at point of sale. Quantitative Real-Time PCR, confirmed that 19.4 and 58.3 % of bile and sausage samples tested positive for TTSuV, respectively. The mean viral load was established as 5.6 × 10(4) GE/µl for bile and 7.16 × 10(3) GE/g for sausages. TTSuV nucleotide sequence analysis confirmed a wide heterogeneity among the circulating TTSuV strains, which included both TTSuV1 and TTSuV2.

  15. LIMITED ANTIBODY EVIDENCE OF EXPOSURE TO MYCOBACTERIUM BOVIS IN FERAL SWINE (SUS SCROFA) IN THE USA.

    PubMed

    Pedersen, Kerri; Miller, Ryan S; Anderson, Theodore D; Pabilonia, Kristy L; Lewis, Jonathan R; Mihalco, Rebecca L; Gortázar, Christian; Gidlewski, Thomas

    2017-01-01

    Bovine tuberculosis is a chronic disease of cattle ( Bos taurus ) caused by the bacterium Mycobacterium bovis . Efforts have been made in the US to eradicate the disease in cattle, but spillover into wildlife and subsequent spillback have impeded progress in some states. In particular, infection in white-tailed deer ( Odocoileus virginianus ) has been followed by infection in cattle in some Midwestern states. Infection has also been documented in feral swine ( Sus scrofa ) on the Hawaiian island of Molokai and in various European countries, but no large-scale survey of antibody exposure to the bacteria has been conducted in feral swine in the US. We tested 488 sera from feral swine collected near previously documented outbreaks of bovine tuberculosis in cattle and captive cervids, in addition to 2,237 feral swine sera collected across the US from 1 October 2013 to 30 September 2014. While all but one of the samples were antibody negative, the results are important for establishing baseline negative data since feral swine are capable reservoirs and could be implicated in future outbreaks of the disease.

  16. The complete mitochondrial genome of Juema pig Sus scrofa (Suina: Suidae) from southern Gansu.

    PubMed

    Xu, Yan-Yan; Tian, Xiao-Xiao; Chen, Lei-Lei; Pan, Hong-Chun

    2016-09-01

    Juema pig is a kind of rare and special pig which is well adapted to high altitude, cold climate and harsh natural environment. The complete mitochondrial genome of Juema pig Sus scrofa is a circular molecule of 16 532 bp in length, containing 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, and a control region. The A + T content of the overall base composition of H-strand is 60.7% (T: 26.2%; C: 26.0%; A: 34.5%; G: 13.3%). ND4L gene begins with GTG as start codon, ND2, ND3, and ND5 genes begin with ATA as a start codon, and other nine protein-coding genes start with ATG. Cyt b gene is terminated with AGA as stop codon, ND1 and ND2 genes are terminated with TAG as stop codon, COII, COIII, ND3, and ND4 end with T, while ATP6, ATP8, COI, ND4L, ND5, and ND6 end with TAA. In addition, the phylogenetic relationships from neighbor-joining analyses based on the 13 concatenated PCGs indicated (Tylopoda (Suina (Ruminantia (Hippopotamidae, Cetacea)))).

  17. Experimental taphonomy: post-mortem microstructural modifications in Sus scrofa domesticus bone.

    PubMed

    Kontopoulos, Ioannis; Nystrom, Pia; White, Lorraine

    2016-09-01

    Bone is a highly specialised form of hard and rigid connective tissue whose histological structure undergoes post-mortem modifications. In taphonomic research, histological examination of bone thin sections is used to investigate these post-mortem microstructural changes in skeletal tissues. In this study, diagenetic modifications in pig skeletal remains (Sus scrofa domesticus) which were exposed to different taphonomic conditions as part of a long-term, real-time experiment were examined under light microscope (i.e. plain and cross polarized light). This experiment demonstrated that macroscopic appearance and microscopic preservation of bone may significantly differ. Early microbial attack was identified as enlarged osteocyte lacunae that later coalesce to constitute larger foci. Additionally, microscopic preservation of different skeletal elements varied intra-individually, while within bone differential preservation (i.e. proximal versus distal ends) was also observed. However, no specific patterns of early histological attack (e.g. endosteal and periosteal destruction) and no clear relationship between histological preservation and proximity to the abdominal area were detected. Lastly, the presence and composition of protective textiles had a clear effect on bone preservation. This research project, therefore, provided important evidence for the better understanding of the diagenetic processes that occur within bones whilst buried or exposed on the ground surface.

  18. Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain.

    PubMed

    Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F; Wahlberg, Lars U; Mufson, Elliott J

    2017-02-15

    Central cholinergic structures within the brain of the even-toed hoofed Goettingen miniature domestic pig (Sus scrofa domesticus) were evaluated by immunohistochemical visualization of choline acetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) . ChAT-immunoreactive (-ir) perikarya were seen in the olfactory tubercle, striatum, medial septal nucleus, vertical and horizontal limbs of the diagonal band of Broca, and the nucleus basalis of Meynert, medial habenular nucleus, zona incerta, neurosecretory arcuate nucleus, cranial motor nuclei III and IV, Edinger-Westphal nucleus, parabigeminal nucleus, pedunculopontine nucleus, and laterodorsal tegmental nucleus. Cholinergic ChAT-ir neurons were also found within transitional cortical areas (insular, cingulate, and piriform cortices) and hippocampus proper. ChAT-ir fibers were seen throughout the dentate gyrus and hippocampus, in the mediodorsal, laterodorsal, anteroventral, and parateanial thalamic nuclei, the fasciculus retroflexus of Meynert, basolateral and basomedial amygdaloid nuclei, anterior pretectal and interpeduncular nuclei, as well as select laminae of the superior colliculus. Double immunofluorescence demonstrated that virtually all ChAT-ir basal forebrain neurons were also p75(NTR) -positive. The present findings indicate that the central cholinergic system in the miniature pig is similar to other mammalian species. Therefore, the miniature pig may be an appropriate animal model for preclinical studies of neurodegenerative diseases where the cholinergic system is compromised. J. Comp. Neurol. 525:553-573, 2017. © 2016 Wiley Periodicals, Inc.

  19. Isolation and characterization of a novel Rhabdovirus from a wild boar (Sus scrofa) in Japan.

    PubMed

    Sakai, Kouji; Hagiwara, Katsuro; Omatsu, Tsutomu; Hamasaki, Chinami; Kuwata, Ryusei; Shimoda, Hiroshi; Suzuki, Kazuo; Endoh, Daiji; Nagata, Noriyo; Nagai, Makoto; Katayama, Yukie; Oba, Mami; Kurane, Ichiro; Saijo, Masayuki; Morikawa, Shigeru; Mizutani, Tetsuya; Maeda, Ken

    2015-09-30

    A novel rhabdovirus was isolated from the serum of a healthy Japanese wild boar (Sus scrofa leucomystax) and identified using the rapid determination system for viral nucleic acid sequences (RDV), next-generation sequencing, and electron microscopy. The virus was tentatively named wild boar rhabdovirus 1 (WBRV1). Phylogenetic analysis of the entire genome sequence indicated that WBRV1 is closely related to Tupaia rhabdovirus (TRV), which was isolated from cultured cells of hepatocellular carcinoma tissue of tree shrew. TRV has not been assigned to any genus of Rhabdoviridae till date. Analysis of the L gene indicated that WBRV1 belongs to the genus Vesiculovirus. These observations suggest that both TRV and WBRV1 belong to a new genus of Rhabdoviridae. Next-generation genome sequencing of WBRV1 revealed 5 open reading frames of 1329, 765, 627, 1629, and 6336 bases in length. The WBRV1 gene sequences are similar to those of other rhabdoviruses. Epizootiological analysis of a population of wild boars in Wakayama prefecture in Japan indicated that 6.5% were positive for the WBRV1 gene and 52% were positive for WBRV1-neutralizing antibodies. Furthermore, such viral neutralizing antibodies were found in domestic pigs in another prefecture. WBRV1 was inoculated intranasally and intraperitoneally into SCID and BALB/c mice and viral RNA was detected in SCID mice, suggesting that WBRV1 can replicate in immunocompromised mice. These results indicate this novel virus is endemic in wild animals and livestock in Japan.

  20. Analysis of muscle and ovary transcriptome of Sus scrofa: assembly, annotation and marker discovery.

    PubMed

    Nie, Qinghua; Fang, Meixia; Jia, Xinzheng; Zhang, Wei; Zhou, Xiaoning; He, Xiaomei; Zhang, Xiquan

    2011-10-01

    Pig (Sus scrofa) is an important organism for both agricultural and medical purpose. This study aims to investigate the S. scrofa transcriptome by the use of Roche 454 pyrosequencing. We obtained a total of 558 743 and 528 260 reads for the back-leg muscle and ovary tissue each. The overall 1 087 003 reads give rise to 421 767 341 bp total residues averaging 388 bp per read. The de novo assemblies yielded 11 057 contigs and 60 270 singletons for the back-leg muscle, 12 204 contigs and 70 192 singletons for the ovary and 18 938 contigs and 102 361 singletons for combined tissues. The overall GC content of S. scrofa transcriptome is 42.3% for assembled contigs. Alternative splicing was found within 4394 contigs, giving rise to 1267 isogroups or genes. A total of 56 589 transcripts are involved in molecular function (40 916), biological process (38 563), cellular component (35 787) by further gene ontology analyses. Comparison analyses showed that 336 and 553 genes had significant higher expression in the back-leg muscle and ovary each. In addition, we obtained a total of 24 214 single-nucleotide polymorphisms and 11 928 simple sequence repeats. These results contribute to the understanding of the genetic makeup of S. scrofa transcriptome and provide useful information for functional genomic research in future.

  1. Seroprevalence of Toxoplasma gondii in hunted wild boars (Sus scrofa) from southeastern France.

    PubMed

    Roqueplo, Cedric; Blaga, Radu; Jean-Lou, Marie; Vallee, Isabelle; Davoust, Bernard

    2017-01-25

    Toxoplasma gondii (Nicolle et Manceaux, 1908) is an obligate intracellular, parasitic protozoan within the phylum Apicomplexa that causes toxoplasmosis in mammalian hosts (including humans) and birds. Since meat of wild boar, Sus scrofa (Linnaeus), has been demonstrated to be a potential source of human infection, a careful evaluation of the prevalence of infection with T. gondii in hunted animals is needed to protect public health. In the Var area in southeastern France, we performed a spatio-temporal survey in order to investigate the prevalence of IgG antibodies in wild boars shot by hunters in the Canjuers military camp during two subsequent hunting seasons. Of 841 wild boars screened, antibodies (IgG) to T. gondii (modified agglutination test, cut-off 1 : 6) were found in 141 (16.8%) muscle extract samples. A significant association (p < 0.001) was found between positivity and age, but not gender, and hunting districts. The results obtained indicate that consumption of raw or undercooked meat from wild boars carries an important risk of infection with T. gondii. Wild boars may be considered as a bioindicator of parasite circulation in this ecosystem.

  2. In Vitro Study of Caecal and Colon Microbial Fermentation Patterns in Wild Boar (Sus scrofa scrofa).

    PubMed

    Pecka-Kiełb, Ewa; Bujok, Jolanta; Miśta, Dorota; Króliczewska, Bozena; Górecka, Justyna; Zawadzki, Wojciech

    2016-01-01

    The aim of this study was to evaluate wild boar (Sus scrofa scrofa) caecal and colon products of microbial activity including short chain fatty acids (SCFA), ammonia and methane concentrations. The in vitro method was applied to caecal and colon contents after 12 and 24-hour incubation with the substrate (wheat bran), or without any additive (control samples). The pH was also measured in each sample. In samples incubated with the substrate, a lower pH was noted as compared to the control (P < 0.001). In terms of the total SCFA concentration, the hindgut microbial fermentation pattern of wild boar was characterized by a high acetate level, followed by propionate and then butyrate at a ratio of 7:1.5:1. Substrate addition decreased acetate molar proportions (P < 0.001) and increased those of butyrate (P < 0.001) as well as propionate (P < 0.05). The total SCFA level in fresh, unincubated caecal samples (128 mmol/kg) was similar to that in the colon (111 mmol/kg). The ammonia concentrations were at the level of 0.8-1.5 mmol/kg of hindgut content and did not differ between the two investigated hindgut parts. Methanogenesis was also similar in the caecum and colon and after 24h was 2.69 mmol/kg and 2.27 for caecal colon control samples, respectively. The substrate increased total gas production and methane concentration (P < 0.001).

  3. Establishing a DNA identification system for pigs (Sus scrofa) using a multiplex STR amplification.

    PubMed

    Lin, Yu-Chih; Hsieh, Hsing-Mei; Lee, James Chun-I; Hsiao, Chung-Ting; Lin, Der-Yuh; Linacre, Adrian; Tsai, Li-Chin

    2014-03-01

    In this study we establish a novel STR multiplex using 13 tetra-nucleotide STRs and the amelogenin marker for the forensic identification of pigs. The genotypes and allele frequency were generated based on 341 samples from 11 pig breeds in Taiwan. Genetic variation was tested including Na, Ne, Ho, He, F-statistics, PIC, Pm and PE for each STR locus and for each breed. Based upon the 341 samples in this study, the CPm and CPEtrio of the 13 STR loci were 1.31 E-11 and 0.9996 respectively. The CPItrio based on ten family sets ranged from 4.012 E+4 to 4.332 E+6 for paternity test. Validation of the multiplex included: determining the sensitivity of the test, where reproducible full DNA profiles were obtained using an initial template of between 0.25 and 1 ng; a comprehensive range of tissue types generated the same genotype; and the specificity was confirmed as no DNA full profile was generated for any species other than Sus scrofa. Based on the phylogenetic analysis, the European domestic breeds clustered separately from the Asian breeds, as expected, and their hybrids formed unique clades respectively between the clades of Asian and European breeds. Eleven test samples, acting as unknown samples, matched all expected breeds. We demonstrate that this novel 14-plex PCR system is valuable in pig individualization, parentage testing, breed assessment, phylogenetic study and forensic applications.

  4. Exposure of feral swine (Sus scrofa) in the United States to selected pathogens.

    PubMed

    Baroch, John A; Gagnon, Carl A; Lacouture, Sonia; Gottschalk, Marcelo

    2015-01-01

    Feral swine (Sus scrofa) are widely distributed in the United States. In 2011 and 2012, serum samples and tonsils were recovered from 162 and 37 feral swine, respectively, in the US to evaluate exposure to important swine endemic pathogens. Antibodies against porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) were found in 2.5% and 25.3% of tested sera, respectively. Positive serological reactions against Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae have been detected in 19.7% and 69.7% of animals. More than 15% of animals presented antibodies against these 2 pathogens simultaneously. Most animals were also seropositive for Lawsonia intracellularis. Feral swine can also be involved in transmission of zoonotic agents. Almost 50% of animals possessed antibodies against Salmonella. In addition, 94.4% of animals were carriers of Streptococcus suis in their tonsils. In conclusion, feral swine may be considered as a potential reservoir for different endemic diseases in domestic pigs, as well as for important zoonotic agents.

  5. Mitochondrial DNA sequence and phylogenetic evaluation of geographically disparate Sus scrofa breeds.

    PubMed

    Cannon, M V; Brandebourg, T D; Kohn, M C; Ðikić, D; Irwin, M H; Pinkert, C A

    2015-01-01

    Next generation sequencing of mitochondrial DNA (mtDNA) facilitates studies into the metabolic characteristics of production animals and their relation to production traits. Sequence analysis of mtDNA from pure-bred swine with highly disparate production characteristics (Mangalica Blonde, Mangalica Swallow-bellied, Meishan, Turopolje, and Yorkshire) was initiated to evaluate the influence of mtDNA polymorphisms on mitochondrial function. Herein, we report the complete mtDNA sequences of five Sus scrofa breeds and evaluate their position within the phylogeny of domestic swine. Phenotypic traits of Yorkshire, Mangalica Blonde, and Swallow-belly swine are presented to demonstrate their metabolic characteristics. Our data support the division of European and Asian breeds noted previously and confirm European ancestry of Mangalica and Turopolje breeds. Furthermore, mtDNA differences between breeds suggest function-altering changes in proteins involved in oxidative phosphorylation such as ATP synthase 6 (MT-ATP6), cytochrome oxidase I (MT-CO1), cytochrome oxidase III (MT-CO3), and cytochrome b (MT-CYB), supporting the hypothesis that mtDNA polymorphisms contribute to differences in metabolic traits between swine breeds. Our sequence data form the basis for future research into the roles of mtDNA in determining production traits in domestic animals. Additionally, such studies should provide insight into how mtDNA haplotype influences the extreme adiposity observed in Mangalica breeds.

  6. 'Post-mortem examination of the reproductive organs of female wild boars (Sus scrofa) in Sweden'.

    PubMed

    Malmsten, Anna; Jansson, Gunnar; Dalin, Anne-Marie

    2017-03-13

    In recent decades, wild boars (Sus scrofa) have increased in numbers and distribution in Europe. Compared to other wild ungulates of similar body size, wild boars have a high reproductive capacity. To increase the knowledge of wild boar reproduction, the objective of this study was to investigate characteristics of reproductive organs, and to provide information on the occurrence of abnormalities in reproductive organs from free-ranging female wild boars. Between December 2011 and December 2015, reproductive organs from female wild boars (>30 kg body weight), were collected during hunting in four Swedish counties at estates where supplementary feeding was applied. The organs were macroscopically examined and measured. The stage of the reproductive cycle was defined according to the ovarian structures and in relation to uterus characteristics. Observed abnormalities were noted. The results from 569 animals that met the requirements to be included in this study showed significant differences in weight and length of the uterus between the various reproductive stages. Sampling region had significant effect on these differences. Abnormalities in the reproductive organs were present in approximately 10% of the examined animals. The prevalence of abnormalities increased significantly with age and was significantly affected by sampling region.

  7. Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis.

    PubMed

    Vale-Gonçalves, H M; Cabral, J A; Faria, M C; Nunes-Pereira, M; Faria, A S; Veloso, O; Vieira, M L; Paiva-Cardoso, Md N

    2015-07-01

    Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochaetes of the genus Leptospira. The wild boar (Sus scrofa), an important hunting species in Europe, seems to play a significant role in the epidemiological cycle of leptospirosis. A total of 101 serum samples from wild boar hunted in Northern Portugal were analysed for leptospiral antibodies detection by microscopic agglutination test. Sera were collected during hunting seasons (2011-2013) and tested with 17 different pathogenic serovars of Leptospira. Antibodies against nine serovars were detected in 66 (65·4%) of these sera. Serovars Tarassovi and Altodouro exhibited the highest seroreactivity rates (23·8% and 16·8%, respectively), followed by Autumnalis (7·9%) and Bratislava (6·9%). Age and district of origin were found to be risk factors for the presence of leptospiral antibodies in contrast to gender. From a One Health perspective, this study revealed that wild boar should be considered as a potential source of leptospirosis dissemination for humans and animal species (domestic and wild) in shared environments, particularly in the Trás-os-Montes region.

  8. Serologic and molecular survey for hepatitis E virus in wild boar (Sus scrofa) in Central Italy.

    PubMed

    Mazzei, M; Nardini, R; Verin, R; Forzan, M; Poli, A; Tolari, F

    2015-09-01

    The aim of this study was to further investigate the role of wild boar (Sus scrofa) as a reservoir for hepatitis E virus (HEV). Sixty-four blood and faecal samples collected from wild boar hunted in Central Italy in 2011-2012 were examined by indirect enzyme-linked immunosorbent assay and RT-PCR analysis. Positive RT-PCR samples were further examined by nucleotide sequence determination and subsequent phylogenetic analysis. Thirty-six sera (56.2%) were positive for HEV-specific antibodies, and six (9.4%) faecal samples scored RT-PCR-positive results. Four animals were positive by both enzyme-linked immunosorbent assay and RT-PCR. Phylogenetic analysis showed that the detected wild boar-derived HEV sequences clustered within genotype 3, with similarity to sequences of human origin collected in a nearby area in 2012. Our data confirm that HEV is endemic in the wild boar population in the research area and that these wild animals could play an important role in the epidemiology of HEV infection.

  9. Spatiotemporal and Ecological Patterns of Mycobacterium microti Infection in Wild Boar (Sus scrofa).

    PubMed

    Chiari, M; Ferrari, N; Giardiello, D; Avisani, D; Pacciarini, M L; Alborali, L; Zanoni, M; Boniotti, M B

    2016-10-01

    Mycobacterium microti has recently been described as the causative agent of tuberculosis-like lesions in wild boar (Sus scrofa), a reservoir specie of Mycobacterium tuberculosis complex (MTBC) in some European Mediterranean ecosystem. Through a five-year survey on tuberculosis in free-living wild boars, the epidemiological trend of M. microti infections and the host and population risk factors linked with its occurrence were described. Retropharyngeal and mandibular lymph nodes of 3041 hunted wild boars from six different districts were macroscopically inspected. The sex and age of each animal were registered, as well as the animal abundance in each district. Lesions compatible with tuberculosis (190) were collected and analysed using a gyrB PCR-RFLP assay. M. microti was identified directly in 99 tissue samples (Prev = 3.26%; 95% CI: 2.67-3.97%), while neither Mycobacterium bovis, nor other members of the MTBC were detected. The probability of being M. microti positive showed spatio-temporal variability, with 26% of increase of risk of being infected for each year. Moreover, a positive effect of wild boar abundance and age on the prevalence was detected. The generalized increase in the European wild boar population, coupled with its sensitivity to M. microti infection, poses a future concern for the identification and management of MTBC members in wild boar.

  10. Hematologic and biochemical reference intervals for Wild Boar (Sus scrofa) captured by cage trap.

    PubMed

    Casas-Díaz, Encarna; Closa-Sebastià, Francesc; Marco, Ignasi; Lavín, Santiago; Bach-Raich, Ester; Cuenca, Rafaela

    2015-06-01

    Establishing reference intervals (RI) for hematologic and biochemical variables in wild animals presents great challenges because capture stress or anesthesia during sampling can affect blood variables. The aims of this study were to establish RI for hematologic and blood biochemistry variables for Wild Boar (Sus scrofa) caught using cage traps, and provide information on the studied variables for different age groups. Blood samples were obtained from 89 Wild Boars captured by cage trap between 2005 and 2013 in northeastern Spain. Piglets were handled without anesthesia, while juvenile and adult animals were anesthetized using a combination of tiletamine and zolazepam. Blood samples were collected from the anterior vena cava and were placed into plain and EDTA tubes. Thirteen hematologic and 21 biochemical variables were determined. Reference intervals for piglets and juvenile and adult groups were determined, and differences between these groups were statistically analyzed. Adults had higher HGB, PCV, MCH, MCHC, neutrophil count, and total protein, albumin, creatinine, and chloride concentrations than juveniles; in contrast, juveniles had higher values for lymphocyte count, cholesterol concentration, and ALP activity. Reference intervals determined in this study provide a baseline for interpreting hematologic and biochemical results in Wild Boar at different age stages, and contribute to optimization of the management of this species. © 2015 American Society for Veterinary Clinical Pathology.

  11. La Resonancia J/$\\psi$ y Sus Implicaciones Para La Masa Del W

    SciTech Connect

    Sanchez-Hernandez, Alberto

    1995-01-01

    Es un placer agradecer a mi asesor el doctor Heriberto Castilla Valdez por brindarme sus conocimientos, experiencia y paciencia en el desarrollo de esta tesis; tambien quiero agradecer al profesor H.E. Fisk, por su apoyo econemico en mi estancia en Fermilab. De igual forma agradezco a los doctores Arturo Fernandez Telles, Miguel Angel Perez Angen y Rebeca Juarez Wisozka quienes me introdujeron al campo de la fisica experimental de altas energfas. Agradezco tambien a Maribel Rios Cruz, Ruben Flores Mendieta, Juan Morales Corona, Fabiola Vazquez Valencia, Salvador Carrillo Moreno y Cecilia Uribe Estrada por su amistad y compaiierismo durante el desarrollo de mi maestria. Un especial agradecimiento a Ian Adam y Kina Denisenko por su valiosa ayuda, comentarios y discusiones durante mi estancia en Fermilab. Por ultimo quisiera agradecer a mis profesores, amigos y familiares quienes siempre me apoyaron y alentaron y al Consejo N acional de Ciencia y Tecnologfa asf como al Departamento de Fisica de Cinvestav por su apoyo econemlco.

  12. Light-absorbing Aerosol Properties in the Kathmandu Valley during SusKat-ABC Field Campaign

    NASA Astrophysics Data System (ADS)

    Kim, S.; Yoon, S.; Kim, J.; Cho, C.; Jung, J.

    2013-12-01

    Light-absorbing aerosols, such as black carbon (BC), are major contributors to the atmospheric heating and the reduction of solar radiation reaching at the earth's surface. In this study, we investigate light-absorption and scattering properties of aerosols (i.e., BC mass concentration, aerosol solar-absorption/scattering efficiency) in the Kathmandu valley during Sustainable atmosphere for the Kathmandu valley (SusKat)-ABC campaign, from December 2012 to February 2013. Kathmandu City is among the most polluted cities in the world. However, there are only few past studies that provide basic understanding of air pollution in the Kathmandu Valley, which is not sufficient for designing effective mitigation measures (e.g., technological, financial, regulatory, legal and political measures, planning strategies). A distinct diurnal variation of BC mass concentration with two high peaks observed during wintertime dry monsoon period. BC mass concentration was found to be maximum around 09:00 and 20:00 local standard time (LST). Increased cars and cooking activities including substantial burning of wood and other biomass in the morning and in the evening contributed to high BC concentration. Low BC concentrations during the daytime can be explain by reduced vehicular movement and cooking activities. Also, the developmements of the boundary layer height and mountain-valley winds in the Kathmandu Valley paly a crucial role in the temproal variation of BC mass concentrations. Detailed radiative effects of light-absorbing aerosols will be presented.

  13. First report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig (Sus scrofa domesticus).

    PubMed

    Oliveira, Manuela; Barroco, Cynthia; Mottola, Carla; Santos, Raquel; Lemsaddek, Abdelhak; Tavares, Luis; Semedo-Lemsaddek, Teresa

    2014-09-21

    Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis, a common disease in small ruminant populations throughout the world and responsible for a significant economic impact for producers. To our knowledge, this is the first characterization of C. pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig (Sus scrofa domesticus). In this study, phenotypic and genotypic identification methods allocated the swine isolates in C. pseudotuberculosis biovar ovis. The vast majority of the isolates were able to produce phospholipase D and were susceptible to most of the antimicrobial compounds tested. Macrorestriction patterns obtained by Pulsed Field Gel Electrophoresis (PFGE) grouped the C. pseudotuberculosis in two clusters with a high similarity index, which reveals their clonal relatedness. Furthermore, swine isolates were compared with C. pseudotuberculosis from caprines and PFGE patterns also showed high similarity, suggesting the prevalence of dominant clones and a potential cross-dissemination between these two animal hosts. This work represents the first report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig and alerts for the importance of the establishment of suitable control and sanitary management practices to control the infection and avoid further dissemination of this important pathogen to other animal hosts.

  14. Genome sequencing reveals fine scale diversification and reticulation history during speciation in Sus

    PubMed Central

    2013-01-01

    Background Elucidating the process of speciation requires an in-depth understanding of the evolutionary history of the species in question. Studies that rely upon a limited number of genetic loci do not always reveal actual evolutionary history, and often confuse inferences related to phylogeny and speciation. Whole-genome data, however, can overcome this issue by providing a nearly unbiased window into the patterns and processes of speciation. In order to reveal the complexity of the speciation process, we sequenced and analyzed the genomes of 10 wild pigs, representing morphologically or geographically well-defined species and subspecies of the genus Sus from insular and mainland Southeast Asia, and one African common warthog. Results Our data highlight the importance of past cyclical climatic fluctuations in facilitating the dispersal and isolation of populations, thus leading to the diversification of suids in one of the most species-rich regions of the world. Moreover, admixture analyses revealed extensive, intra- and inter-specific gene-flow that explains previous conflicting results obtained from a limited number of loci. We show that these multiple episodes of gene-flow resulted from both natural and human-mediated dispersal. Conclusions Our results demonstrate the importance of past climatic fluctuations and human mediated translocations in driving and complicating the process of speciation in island Southeast Asia. This case study demonstrates that genomics is a powerful tool to decipher the evolutionary history of a genus, and reveals the complexity of the process of speciation. PMID:24070215

  15. Genome sequencing reveals fine scale diversification and reticulation history during speciation in Sus.

    PubMed

    Frantz, Laurent A F; Schraiber, Joshua G; Madsen, Ole; Megens, Hendrik-Jan; Bosse, Mirte; Paudel, Yogesh; Semiadi, Gono; Meijaard, Erik; Li, Ning; Crooijmans, Richard P M A; Archibald, Alan L; Slatkin, Montgomery; Schook, Lawrence B; Larson, Greger; Groenen, Martien A M

    2013-01-01

    Elucidating the process of speciation requires an in-depth understanding of the evolutionary history of the species in question. Studies that rely upon a limited number of genetic loci do not always reveal actual evolutionary history, and often confuse inferences related to phylogeny and speciation. Whole-genome data, however, can overcome this issue by providing a nearly unbiased window into the patterns and processes of speciation. In order to reveal the complexity of the speciation process, we sequenced and analyzed the genomes of 10 wild pigs, representing morphologically or geographically well-defined species and subspecies of the genus Sus from insular and mainland Southeast Asia, and one African common warthog. Our data highlight the importance of past cyclical climatic fluctuations in facilitating the dispersal and isolation of populations, thus leading to the diversification of suids in one of the most species-rich regions of the world. Moreover, admixture analyses revealed extensive, intra- and inter-specific gene-flow that explains previous conflicting results obtained from a limited number of loci. We show that these multiple episodes of gene-flow resulted from both natural and human-mediated dispersal. Our results demonstrate the importance of past climatic fluctuations and human mediated translocations in driving and complicating the process of speciation in island Southeast Asia. This case study demonstrates that genomics is a powerful tool to decipher the evolutionary history of a genus, and reveals the complexity of the process of speciation.

  16. Snaring to control feral pigs sus scrofa in a remote Hawaiian rain forest

    USGS Publications Warehouse

    Anderson, Stephen J.; Stone, Charles P.

    1993-01-01

    Feral pig Sus scrofa control in Kipahulu Valley, a remote rain forest in Haleakala National Park, Maui, Hawaiian Islands, has been achieved with snares over a 45-month period. Initial pig densities in fenced management units of 6·2 km2 and 7·8 km2were estimated at 6 animals/km2 and 14·3 animals/km2 for the two units, based on population reconstruction from animals killed and aged. During the 45 months of the study, 1978 snares were set, and 1·6 million snare nights were logged. Snare density reached 96/km2 and 200/km2 for the two management units by the end of the study. A mean effort of 43 worker hours/pig was used to remove 53 pigs from the upper management unit, and a mean of 7 worker hours/pig to remove 175 animals from the more densely populated lower unit. Pig activity monitoring along transects provided a good measure of control effectiveness until densities of about 1 pig/km2 were achieved, after which transects became less useful than scouting for determining pig activity.

  17. Neospora caninum exposure in overlapping populations of coyotes (Canis latrans) and feral swine (Sus scrofa).

    PubMed

    Bevins, Sarah; Blizzard, Emily; Bazan, Luis; Whitley, Pat

    2013-10-01

    Limited information exists on Neospora caninum transmission dynamics in wildlife. This coccidian parasite, whose presence can lead to substantial economic losses in cattle operations, requires a canid definitive host for reproduction. We examined exposure in a definitive host, coyotes (Canis latrans), and in overlapping populations of feral swine (Sus scrofa) to determine if spatial proximity between a definitive and incidental host influences the likelihood of parasite exposure. Eighteen percent of coyotes (95% confidence interval [CI] = 14.2-21.8) and 15.8% of feral swine (95% CI = 12.5-19.2) had been exposed to N. caninum, and this is the first report of exposure in US feral swine populations. Analyses suggest that the parasite is present throughout the environment and that exposure is not temporally or spatially linked to antibody-positive coyotes. Antibody-positive feral swine were found in an area where the only definitive host is domestic dogs (Canis familiaris), indicating that wild canids are not required to maintain the parasite in the environment.

  18. Immobilization of collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa) with Telazol and xylazine.

    PubMed

    Gabor, T M; Hellgren, E C; Silvy, N J

    1997-01-01

    A 1:1 mg mixture of Telazol and xylazine hydrochloride (100 mg of Telazol and 100 mg of xylazine per ml) was used to immobilize wild collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa); mean (+/-SD) intramuscular dosage rate was 4.73 +/- 0.86 mg/kg and 4.35 +/- 0.68 mg/kg for peccaries (n = 107) and hogs (n = 49), respectively. Mean (+/-SD) induction time (time from injection until complete immobilization) was 4.6 +/- 2.5 minutes for collared peccaries and 4.4 +/- 1.9 for hogs. Peccaries became conscious at 64 +/- 29 minutes and first stood at 92 +/- 33 minutes after initial injection. Hogs became conscious at 54 +/- 26 minutes and first stood at 78 +/- 38 minutes after initial injection. A 1:1 mg mixture of Telazol and xylazine provided an effective and safe method to immobilize both species and provided adequate analgesia and anesthesia for short surgical procedures.

  19. Identification and antimicrobial resistance of microflora colonizing feral pig (Sus scrofa) of Brazilian Pantanal.

    PubMed Central

    Lessa, SS; Paes, RCS; Santoro, PN; Mauro, RA; Vieira-da-Motta, O

    2011-01-01

    Antimicrobial resistance of bacteria is a worldwide problem affecting wild life by living with resistant bacteria in the environment. This study presents a discussion of outside factors environment on microflora of feral pigs (Sus scrofa) from Brazilian Pantanal. Animals had samples collected from six different body sites coming from two separated geographic areas, Nhecolandia and Rio Negro regions. With routine biochemical tests and commercial kits 516 bacteria were identified, with 240 Gram-positive, predominantly staphylococci (36) and enterococci (186) strains. Among Gram-negative (GN) bacteria the predominant specimens of Enterobacteriaceae (247) mainly represented by Serratia spp. (105), Escherichia coli (50), and Enterobacter spp. (40) and specimens not identified (7). Antimicrobial susceptibility was tested against 17 drugs by agar diffusion method. Staphylococci were negative to production of enterotoxins and TSST-1, with all strains sensitive towards four drugs and highest resistance toward ampicillin (17%). Enterococci presented the highest sensitivity against vancomycin (98%), ampicillin (94%) and tetracycline (90%), and highest resistance pattern toward oxacillin (99%), clindamycin (83%), and cotrimoxazole (54%). In GN the highest resistance was observed with Serratia marcescens against CFL (98%), AMC (66%) and AMP (60%) and all drugs was most effective against E. coli SUT, TET (100%), AMP, TOB (98%), GEN, CLO (95%), CFO, CIP (93%). The results show a new profile of oxacillin-resistant enterococci from Brazilian feral pigs and suggest a limited residue and spreading of antimicrobials in the environment, possibly because of low anthropogenic impact reflected by the drug susceptibility profile of bacteria isolated. PMID:24031689

  20. Sus scrofa papillomavirus 2 - genetic characterization of a novel suid papillomavirus from wild boar in Germany.

    PubMed

    Link, Ellen Kathrin; Hoferer, Marc; Strobel, Birte; Rigbers, Kerstin; Langenmayer, Martin Christoph; Sutter, Gerd; Fux, Robert

    2017-08-01

    We identified a novel papillomavirus, Sus scrofa papillomavirus 2 (SsPV2), which is the first papillomavirus associated with papillomas in pigs. In skin alterations of a German wild boar, showing typical gross and histological appearance of papillomas, papillomavirus-like particles were demonstrated by electron microscopy. Degenerate papillomavirus-specific primers were used to amplify and sequence parts of the viral DNA. Subsequently, the complete genomic DNA was cloned and sequenced. The SsPV2 genome had a length of 8218 bp, encoded the early proteins E6, E7, E1 and E2, the late proteins L1 and L2 and contained an upstream regulatory region. Genomic characterization demonstrated papillomavirus-typical characteristics as well as unique features. For example, the E2 protein was significantly larger than in every other known papillomavirus species. Phylogenetic analysis was not able to relate SsPV2 unambiguously with other papillomavirus species or existing genera. Therefore, it might be representative of a new papillomavirus genus.

  1. Genetic characterization and phylogeography of the wild boar Sus scrofa introduced into Uruguay

    PubMed Central

    García, Graciela; Vergara, Julia; Lombardi, Raúl

    2011-01-01

    The European wild boar Sus scrofa was first introduced into Uruguay, in southern South America during the early decades of the last century. Subsequently, and starting from founder populations, its range spread throughout the country and into the neighbouring Brazilian state Rio Grande do Sul. Due to the subsequent negative impact, it was officially declared a national pest. The main aim in the present study was to provide a more comprehensive scenario of wild boar differentiation in Uruguay, by using mtDNA markers to access the genetic characterization of populations at present undergoing rapid expansion. A high level of haplotype diversity, intermediate levels of nucleotide diversity and considerable population differentiation, were detected among sampled localities throughout major watercourses and catchment dams countrywide. Phylogenetic analysis revealed the existence of two different phylogroups, thereby reflecting two deliberate introduction events forming distantly genetic lineages in local wild boar populations. Our analysis lends support to the hypothesis that the invasive potential of populations emerge from introgressive hybridization with domestic pigs. On taking into account the appreciable differentiation and reduced migration between locales in wild boar populations, management strategies could be effective if each population were to be considered as a single management unit. PMID:21734838

  2. Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus.

    PubMed

    Schwartz, John C; Lefranc, Marie-Paule; Murtaugh, Michael P

    2012-05-01

    We have characterized the organization, complexity, and expression of the porcine (Sus scrofa domestica) immunoglobulin lambda (IGL) light chain locus, which accounts for about half of antibody light chain usage in swine, yet is nearly totally unknown. Twenty-two IGL variable (IGLV) genes were identified that belong to seven subgroups. Nine genes appear to be functional. Eight possess stop codons, frameshifts, or both, and one is missing the V-EXON. Two additional genes are missing an essential cysteine residue and are classified as ORF (open reading frame). The IGLV genes are organized in two distinct clusters, a constant (C)-proximal cluster dominated by genes similar to the human IGLV3 subgroup, and a C-distal cluster dominated by genes most similar to the human IGLV8 and IGLV5 subgroups. Phylogenetic analysis reveals that the porcine IGLV8 subgroup genes have recently expanded, suggesting a particularly effective role in immunity to porcine-specific pathogens. Moreover, expression of IGLV genes is nearly exclusively restricted to the IGLV3 and IGLV8 genes. The constant locus comprises three tandem cassettes comprised of a joining (IGLJ) gene and a constant (IGLC) gene, whereas a fourth downstream IGLJ gene has no corresponding associated IGLC gene. Comparison of individual BACs generated from the same individual revealed polymorphisms in IGLC2 and several IGLV genes, indicating that allelic variation in IGLV further expands the porcine antibody light chain repertoire.

  3. Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2.

    PubMed

    Yu, Yejin; Liu, Xiaoxiao; Zhang, Zheren; Xiao, Yunpeng; Hong, Mei

    2013-08-01

    1. Organic anion transporting polypeptides (OATPs) are a family of transporter proteins that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion of various drugs. Human OATP1A2 has been demonstrated to transport wide spectrum of endogenous and exogenous compounds. Study on OATP1A2 orthologues of other species, however, is still limited. 2. Here, we described the cloning and functional characterization of a member of the OATP/Oatp family member obtained from pig (Sus scrofa) liver. Sequence analysis suggested that it has a high homology with human OATP1A2 and bovine Oatp1a2. Prototypic substrates estrone-3-sulfate (E-3-S) and taurocholic acid were transported by the protein. The transport of these two substrates is pH-dependent, with lower pH showing higher uptake function. Kinetic study showed the transport of these two substrates have a Km of 42.5 ± 12.1 and 33.1 ± 8.7 µM, respectively. Pig Slco1a2 has the highest expression level in the liver, and to a less extend in the brain and small intestine. 3. In conclusion, an OATP member was cloned from pig liver. Sequence analysis and phylogenic study revealed it as an orthologue of human OATP1A2. Its kinetic characteristic for prototypic substrates and organ distribution are similar with that of OATP1A2.

  4. Serologic and molecular survey for hepatitis E virus in wild boar (Sus scrofa) in Central Italy

    PubMed Central

    Mazzei, M.; Nardini, R.; Verin, R.; Forzan, M.; Poli, A.; Tolari, F.

    2015-01-01

    The aim of this study was to further investigate the role of wild boar (Sus scrofa) as a reservoir for hepatitis E virus (HEV). Sixty-four blood and faecal samples collected from wild boar hunted in Central Italy in 2011–2012 were examined by indirect enzyme-linked immunosorbent assay and RT-PCR analysis. Positive RT-PCR samples were further examined by nucleotide sequence determination and subsequent phylogenetic analysis. Thirty-six sera (56.2%) were positive for HEV-specific antibodies, and six (9.4%) faecal samples scored RT-PCR-positive results. Four animals were positive by both enzyme-linked immunosorbent assay and RT-PCR. Phylogenetic analysis showed that the detected wild boar–derived HEV sequences clustered within genotype 3, with similarity to sequences of human origin collected in a nearby area in 2012. Our data confirm that HEV is endemic in the wild boar population in the research area and that these wild animals could play an important role in the epidemiology of HEV infection. PMID:26199731

  5. Test research on sticking mechanism during hot rolling of SUS 430 ferritic stainless steel

    NASA Astrophysics Data System (ADS)

    Liu, Jun-Xian; Zhang, Yong-Jun; Han, Jing-Tao

    2010-10-01

    The sticking phenomenon during hot rolling of SUS 430 ferritic stainless steel was investigated by means of a two-disc type high-temperature wear tester. The test results indicate that sticking particles on the surfaces of high chromium steel (HiCr) and high-speed steel (HSS) rolls undergo nucleation, growth, and saturation stages. Grooves on the roll surface generated by grinding provide nucleation sites for sticking particles. The number of sticking particles on the HiCr roll surface is greater than that on the HSS roll surface. The average surface roughnesses ( R a) of HiCr and HSS rolls change from 0.502 and 0.493 μm at the initial stage to 0.837 and 0.530 μm at the saturation stage, respectively. The test further proves that the sticking behavior is strongly dependent on roll materials, and the HSS roll is more beneficial to prevent particles sticking compared with the HiCr roll under the same hot-rolling conditions.

  6. Shifts in soil biodiversity-A forensic comparison between Sus scrofa domesticus and vegetation decomposition.

    PubMed

    Olakanye, Ayodeji O; Thompson, Tim; Ralebitso-Senior, T Komang

    2015-12-01

    In a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. As a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. For this study, domestic pig (Sus scrofa domesticus) (4g) and grass (Agrostis/Festuca spp) cuttings (4g) were buried (July 2013 to July 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 ml; 50 × 70 cm) with parallel soil only controls. The effects of the two carbon sources were determined by monitoring key environmental factors and changes in soil bacterial (16S rRNA gene) and fungal (18S rRNA gene) biodiversity. Soil pH changes showed statistically significant differences (p<0.05) between the treatments. The measured ecological diversity indices (Shannon-Wiener, HꞋ; Simpson, D; and richness, S) of the 16S rRNA and 18S rRNA gene profiles also revealed differences between the treatments, with bacterial and fungal community dominance recorded in the presence of S. scrofa domesticus and grass trimming decomposition, respectively. In contrast, no statistically significant difference in evenness (p>0.05) was observed between the treatments.

  7. [The feral pig (Sus scrofa, Suidae) in Cocos Island, Costa Rica: Rootings, soil alterations and erosion].

    PubMed

    Sierra, C

    2001-01-01

    Feral pigs (Sus scrofa) are of the most damaging exotic vertebrates, specially on oceanic island native communities. Feral pigs inhabit Cocos Island since 1793 and there are around 400-500 individuals. In order to quantify the impacts of the feral pigs at Cocos Island. I calculated the effect of the rooting activity and its influence on the natural erosion. During one year I walked, monthly, 15 km on trails estimating rooted area by transect and rooting recurrence. During eight months I compared erosion rates with and without rootings. I estimated the annual rooting rate between 10 and 20% of the total island surface. The rooted area was the only measured variable which correlated with the soil erosion rate. The erosion rate without rootings was 23.6 kg/ha/year and with rootings was 200.4 kg/ha/year (P < 0.01). The disturbances provoked by the rootings were not scattered homogeneously through the island. The rootings, together with the natural landslides, dominate the soil disturbance pattern at Cocos Island. This study suggests that the presence of feral pigs produces more erosion than the one that would naturally occur without feral pigs at Cocos Island.

  8. Shigella infection as observed in the experimentally inoculated domestic pig, Sus scrofa domestica.

    PubMed

    Maurelli, A T; Routh, P R; Dillman, R C; Ficken, M D; Weinstock, D M; Almond, G W; Orndorff, P E

    1998-10-01

    The domestic pig, Sus scrofa domestica, was investigated as a potential animal model for shigellosis. We examined the effects of pig age, pig breed and antibiotic pretreatment upon Shigella infection. Shigella dysenteriae, and Shigella flexneri (both virulent and avirulent strains) were utilized. Our results indicated that young (4-week-old), conventionally re ared, domestic pigs were routinely, but briefly, colonized (average=3.5+/-2.5 days) following oral or gavage administration ofS. flexneri, as determined by direct rectal cultures. The duration of S. dysenteriae colonization was significantly shorter. Inoculation of younger (2 days) or older (9 weeks) pigs with S. flexneri had no significant effect on infection duration. Similarly, infection of 4-week-old pigs with virulent and avirulent strains of S. flexneri had no effect upon the duration of infection, nor did the use of a swine-passaged S. flexneri isolate. Marked clinical, histopathological (gross and microscopic) and immunoIhistopathological signs of disease were absent in all infections. However, in instances where microscopic histopathological evidence was used to correctly identify infected pigs, tonsillar lesions were the consistently noted criteria. The tonsils are believed to be an important portal of entry for Salmonella choleraesuis, another member of the Enterobacteriaceae and a prevalent pig pathogen. Taken altogether, our results indicate that the domestic pig is unsuitable as a model for shigellosis. Copyright 1998 Academic Press.

  9. Developmental changes affecting lectin binding in the vomeronasal organ of domestic pigs, Sus scrofa.

    PubMed

    Park, Junwoo; Lee, Wonho; Jeong, Chanwoo; Kim, Hwangryong; Taniguchi, Kazumi; Shin, Taekyun

    2012-01-01

    This study investigated the developmental changes of glycoconjugate patterns in the porcine vomeronasal organs (VNOs) and associated glands (Jacobson's glands) from prenatal (9 weeks of gestation) and postnatal (2 days after birth) to the sexually mature stage (6 months old). The VNO of pigs (Sus scrofa) was examined using the following: Dolichos biflorus agglutinin (DBA), Bandeiraea simplicifolia agglutinin isolectin B4 (BSI-B4), Triticum vulgaris agglutinin (WGA), Ulex europaeus agglutinin I (UEA-I), and soybean agglutinin (SBA). At the fetal stage, all lectins examined were detected mainly in the free border of the vomeronasal epithelium, but few (WGA and UEA-I) and or absent in the VNO cell bodies. At the postnatal and sexually mature stages, the reactivity of some lectins, including WGA, UEA-I, DBA and SBA, were shown to increase in the VNO sensory epithelium as well as the free border. The increased reactivity of lectins as development progressed was also observed in Jacobson's gland acini. These findings suggest that binding sites of lectins, including those of WGA, UEA-I, DBA, and SBA, increase during development from fetal to postnatal growth, possibly contributing to the increased ability of chemoreception in the pig.

  10. Functional cues in the development of osseous tooth support in the pig, Sus scrofa.

    PubMed

    Popowics, T; Yeh, K; Rafferty, K; Herring, S

    2009-08-25

    Alveolar bone supports teeth during chewing through a ligamentous interface with tooth roots. Although tooth loads are presumed to direct the development and adaptation of these tissues, strain distribution in the alveolar bone at different stages of tooth eruption and periodontal development is unknown. This study investigates the biomechanical effects of tooth loading on developing alveolar bone as a tooth erupts into occlusion. Mandibular segments from miniature pigs, Sus scrofa, containing M(1) either erupting or in functional occlusion, were loaded in compression. Simultaneous recordings were made from rosette strain gages affixed to the lingual alveolar bone and the M(2) crypt. Overall, specimens with erupting M(1)s were more deformable than specimens with occluding M(1)s (mean stiffness of 246 vs. 944 MPa, respectively, p=0.004). The major difference in alveolar strain between the two stages was in orientation. The vertically applied compressive loads were more directly reflected in the alveolar bone strains of erupting M(1)s, than those of occluding M(1)s, presumably because of the mediation of a more mature periodontal ligament (PDL) in the latter. The PDL interface between occluding teeth and alveolar bone is likely to stiffen the system, allowing transmission of occlusal loads. Alveolar strains may provide a stimulus for bone growth in the alveolar process and crest.

  11. Mycobacterium tuberculosis Infection in a Domesticated Korean Wild Boar ( Sus scrofa coreanus).

    PubMed

    Seo, Min-Goo; Ouh, In-Ohk; Kim, Munki; Lee, Jienny; Kim, Young-Hoan; Do, Jae-Cheul; Kwak, Dongmi

    2017-06-01

    Tuberculosis, a chronic progressive disease, has been reported in bovine, swine, and primate species. Here, we report the first case of Mycobacterium tuberculosis infection in a Korean wild boar ( Sus scrofa coreanus). The owners this domesticated boar brought it to the Gyeongbuk Veterinary Service Laboratory in Korea after it was found dead and severely emaciated. Demarcated yellowish white nodules were found around the larynx and retropharyngeal lymph node during necropsy. The lungs had diffuse fibrinous pleuritis, severe congestion, and scattered nodules. More nodules were found in the spleen. Tuberculosis is characterized by massive macrophage infiltration and central caseous necrosis; both characteristics were found in the lungs. Histopathologic examination revealed that the alveolar lumen had marked fibrosis and exudates. Examination of the fluid revealed extensive macrophage permeation. To confirm a Mycobacterium infection, PCR was performed using two primer sets specific to the rpoB gene of Mycobacterium; Mycobacterium was detected in the lungs and spleen. To identify the species of Mycobacterium, immunohistochemical evaluation was performed using antibodies against Mycobacterium tuberculosis and Mycobacterium bovis . The results revealed immunoreactivity against M. tuberculosis but not against M. bovis . The consumption of undercooked or raw meat from game animals may expose humans and other animals to sylvatic infection. Consequently, Koreans who ingest wild boar may be at risk of a tuberculosis infection. To reduce the risk of foodborne infection and maintain public health, continuous monitoring and control strategies are required.

  12. Dissimilar welding of nickel-based Alloy 690 to SUS 304L with Ti addition

    NASA Astrophysics Data System (ADS)

    Lee, H. T.; Jeng, S. L.; Yen, C. H.; Kuo, T. Y.

    2004-10-01

    This study investigates the effects of Ti addition on the weldability, microstructure and mechanical properties of a dissimilar weldment of Alloy 690 and SUS 304L. Shielding metal arc welding (SMAW) is employed to butt-weld two plates with three welding layers, where each layer is deposited in a single pass. To investigate the effects of Ti addition, the flux coatings of the electrodes used in the welding process are modified by varying additions of either a Ti-Fe compound or a Ti powder. The results indicate that the microstructure of the fusion zone (FZ) is primarily dendritic. With increasing Ti content, it is noted that the microstructure changes from a columnar dendritic to an equiaxed dendritic, in which the primary dendrite arm spacing (PDAS) becomes shorter. Furthermore, it is observed that the amount of Al-Ti oxide phase increases in the inter-dendritic region, while the amount of Nb-rich phase decreases. Moreover, the average hardness of the FZ increases slightly. The results indicate that Ti addition prompts a significant increase in the elongation of the weldment (i.e. 36.5%, Ti: 0.41 wt%), although the tensile strength remains relatively unchanged. However, at an increased Ti content of 0.91 wt%, an obvious reduction in the tensile strength is noted, which can be attributed to a general reduction in the weldability of the joint.

  13. [The contemporary relationship between work, qualification and recognition: repercussions on the Unified Health System (SUS) workers].

    PubMed

    Vieira, Monica; Chinelli, Filippina

    2013-06-01

    This paper discusses the relationship between work, qualification and recognition as it occurs in the field of health today, specifically considering the employability of technical workers in the Unified Health System, the way they perceive the employment relationship with respect to their self-esteem regarding their subjectivities. Based on a review of the relevant literature, the subject is treated in the wider context of ongoing changes in the workplace, which are associated with intensification, flexibility and precariousness of labor relations, with repercussions on the specific aspects mentioned. An attempt is made to establish a critical dialogue with the analytical aspect that emphasizes daily work as a privileged forum for overcoming the contradictions that characterize the field of work and education in the SUS nowadays. The text emphasizes the following issues: analysis of the relationship between work and education from the perspective of the concept of skill; the broadening of the meaning of health work; and a critical evaluation of policies that end up making the workers liable for the quality of services rendered.

  14. An Overview-NASA LeRC Structures Program

    NASA Technical Reports Server (NTRS)

    Zaretsky, Erwin V.

    1997-01-01

    The Structures and Acoustics Division of the NASA Lewis Research Center has its genesis dating back to 1943. It has been an independent Division at Lewis since 1979. Its two primary capabilities are performance and life analysis of static and dynamic systems such as those found in aircraft and spacecraft propulsion systems and experimental verification of these analyses. Research is conducted in-house, through university grants and contracts, and through cooperative programs with industry. Our work directly supports NASA's Advanced Subsonic Technology (AST), Smart Green Engine, Fast Quiet Engine, High-Temperature Materials and Processing (HiTEMP), Hybrid Hyperspeed Propulsion, Rotorcraft, High-Speed Research (HSR), and Aviation Safety Program (AvSP). A general overview is given discussing these programs and other technologies that are being developed at NASA LeRC.

  15. Design of Multidimensional Shinnar-Le Roux RF Pulses

    PubMed Central

    Ma, Chao; Liang, Zhi-Pei

    2014-01-01

    Purpose To generalize the conventional Shinnar-Le Roux (SLR) method for the design of multidimensional RF pulses. Methods Using echo-planar gradients, the multidimensional RF pulse design problem was converted into a series of 1D polynomial design problems. Each of the 1D polynomial design problems was solved efficiently. B0 inhomogeneity compensation and design of spatial-spectral pulses were also considered. Results The proposed method was used to design 2D excitation and refocusing pulses. The results were validated through Bloch equation simulation and experiments on a 3.0 T scanner. Large-tip-angle, equiripple-error, multidimensional excitation was achieved with ripple levels closely matching the design specifications. Conclusion The conventional SLR method can be extended to design multidimensional RF pulses. The proposed method achieves almost equiripple excitation errors, allows easy control of the tradeoff among design parameters, and is computationally efficient. PMID:24578212

  16. The NASA-LeRC wind turbine sound prediction code

    NASA Technical Reports Server (NTRS)

    Viterna, L. A.

    1981-01-01

    Since regular operation of the DOE/NASA MOD-1 wind turbine began in October 1979 about 10 nearby households have complained of noise from the machine. Development of the NASA-LeRC with turbine sound prediction code began in May 1980 as part of an effort to understand and reduce the noise generated by MOD-1. Tone sound levels predicted with this code are in generally good agreement with measured data taken in the vicinity MOD-1 wind turbine (less than 2 rotor diameters). Comparison in the far field indicates that propagation effects due to terrain and atmospheric conditions may be amplifying the actual sound levels by about 6 dB. Parametric analysis using the code has shown that the predominant contributions to MOD-1 rotor noise are: (1) the velocity deficit in the wake of the support tower; (2) the high rotor speed; and (3) off column operation.

  17. LeRoy Doggett and Daylight Saving Time: A Reminiscence

    NASA Astrophysics Data System (ADS)

    Bartky, I. R.

    1997-12-01

    Daylight Saving Time (DST) has been a concern of Congress ever since its adoption in 1918. Yet, not until 1976 did Members of Congress have astronomical, geographic and demographic information in terms of the country's Standard Time zones. This information and various impact analyses were developed by the National Bureau of Standards (NBS) at the request of the House of Representatives, which was reviewing the effects of a two-year, DST experiment on the American public. The displays in the study gave legislators a way to consider alternate observance periods in a systematic manner. The leader of the DST study team will detail LeRoy Doggett's involvement during the hectic, three-month analysis period that culminated with NBS officials testifying before Congress.

  18. An Overview-NASA LeRC Structures Program

    NASA Technical Reports Server (NTRS)

    Zaretsky, Erwin V.

    1997-01-01

    The Structures and Acoustics Division of the NASA Lewis Research Center has its genesis dating back to 1943. It has been an independent Division at Lewis since 1979. Its two primary capabilities are performance and life analysis of static and dynamic systems such as those found in aircraft and spacecraft propulsion systems and experimental verification of these analyses. Research is conducted in-house, through university grants and contracts, and through cooperative programs with industry. Our work directly supports NASA's Advanced Subsonic Technology (AST), Smart Green Engine, Fast Quiet Engine, High-Temperature Materials and Processing (HiTEMP), Hybrid Hyperspeed Propulsion, Rotorcraft, High-Speed Research (HSR), and Aviation Safety Program (AvSP). A general overview is given discussing these programs and other technologies that are being developed at NASA LeRC.

  19. Aerospace Test Facilities at NASA LeRC Plumbrook

    NASA Technical Reports Server (NTRS)

    1992-01-01

    An overview of the facilities and research being conducted at LeRC's Plumbrook field station is given. The video highlights four main structures and explains their uses. The Space Power Facility is the world's largest space environment simulation chamber, where spacebound hardware is tested in simulations of the vacuum and extreme heat and cold of the space plasma environment. This facility was used to prepare Atlas 1 rockets to ferry CRRES into orbit; it will also be used to test space nuclear electric power generation systems. The Spacecraft Propulsion Research Facility allows rocket vehicles to be hot fired in a simulated space environment. In the Cryogenic Propellant Tank Facility, researchers are developing technology for storing and transferring liquid hydrogen in space. There is also a Hypersonic Wind Tunnel which can perform flow tests with winds up to Mach 7.

  20. Plasma Science Contribution to the SCaLeS Report

    SciTech Connect

    S.C. Jardin

    2003-10-09

    In June of 2003, about 250 computational scientists and mathematicians being funded by the DOE Office of Science met in Arlington, VA, to attend a 2-day workshop on the Science Case for Large-scale Simulation (SCaLeS). This document was the output of the Plasma Science Section of that workshop. The conclusion is that exciting and important progress can be made in the field of Plasma Science if computer power continues to grow and algorithmic development continues to occur at the rate that it has in the past. Full simulations of burning plasma experiments could be possible in the 5-10 year time frame if an aggressive growth program is launched in this area.

  1. Neptune's Discovery: Le Verrier, Adams, and the Assignment of Credit

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2011-01-01

    As one of the most significant achievements of 19th century astronomy, the discovery of Neptune has been the subject of a vast literature. A large part of this literature--beginning with the period immediately after the optical discovery in Berlin--has been the obsession with assigning credit to the two men who attempted to calculate the planet's position (and initially this played out against the international rivalry between France and England). Le Verrier and Adams occupied much different positions in the Scientific Establishments of their respective countries; had markedly different personalities; and approached the investigation using different methods. A psychiatrist and historian of astronomy tries to provide some new contexts to the familiar story of the discovery of Neptune, and argues that the personalities of these two men played crucial roles in their approaches to the problem they set themselves and the way others reacted to their stimuli. Adams had features of high-functioning autism, while Le Verrier's domineering, obsessive, orderly personality--though it allowed him to be immensely productive--eventually led to serious difficulties with his peers (and an outright revolt). Though it took extraordinary smarts to calculate the position of Neptune, the discovery required social skills that these men lacked--and thus the process to discovery was more bumbling and adventitious than it might have been. The discovery of Neptune occurred at a moment when astronomy was changing from that of heroic individuals to team collaborations involving multiple experts, and remains an object lesson in the sociological aspects of scientific endeavor.

  2. Dysfonctionnements radio-induits du transport colique chez le rat

    NASA Astrophysics Data System (ADS)

    François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

    1998-04-01

    The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

  3. Les fluctuations supraconductrices dans le compose praseodyme-cerium-oxyde de cuivre

    NASA Astrophysics Data System (ADS)

    Renaud, Jacques

    Ce travail etudie les fluctuations supraconductrices dans le compose supraconducteur a haute temperature critique dope aux electrons Pr2-xCe xCuO4+delta. La technique utilisee pour sonder ces fluctuations est le transport electrique DC dans le plan ab. Il s'agit, a notre connaissance, de la premiere etude de ce type dans la classe generale des supraconducteurs a haute temperature critique dopes aux electrons et, plus particulierement, dans Pr2-xCe xCuO4+delta. De plus, l'etude est effectuee pour trois regimes de dopage, soit sous-dope x = 0.135, dopage optimal x = 0.15 et surdope x = 0.17. Les echantillons etudies sont des couches minces d'epaisseur plus grande que 100 nm crues par ablation laser. Les mesures electriques DC effectuees dans ce travail sont la resistance en reponse lineaire et les courbes IV en reponse non lineaire en fonction de la temperature. La mise en oeuvre experimentale de ces mesures a necessite une grande attention au filtrage et aux effets de chauffage a haut courant. Nous montrons que, sans cette attention, les donnees experimentales sont toujours erronees dans le regime pertinent pour nos echantillons. Les resultats pour le dopage optimal x = 0.15 sont expliques de facon tres convaincante dans le cadre de fluctuations purement 2D. D'abord, le regime des fluctuations gaussiennes est tres bien decrit par le modele d'Aslamazov-Larkin en deux dimensions. Ensuite, le regime de fluctuations critiques, se trouvant a plus basse temperature que le regime gaussien, est tres bien decrit par la physique 2D de Kosterlitz-Thouless. Dans cette analyse, les deux regimes ont des temperatures critiques coherentes entre elles, ce qui semble confirmer ce scenario 2D. Une analyse des donnees dans le cadre de fluctuations 3D est exploree mais donne des conclusions incoherentes. Les resultats pour les autres dopages sont qualitativement equivalents avec le dopage optimal et permettent donc une explication purement 2D. Par contre, contrairement au dopage optimal

  4. Helminth Parasites of Wild Boars, Sus scrofa, in Bushehr Province, Southwestern Iran

    PubMed Central

    MANSOURI, Majid; SARKARI, Bahador; MOWLAVI, Gholam Reza

    2016-01-01

    Background: Wild boars, Sus scrofa, of wide distribution considered as a potential source of zoonotic parasites. The current study aimed to assess the prevalence of helminth infections in wild boars in the Persian Gulf coastal area (Bushehr Province), Southwestern Iran. Methods: Twenty-five wild boars, including 11 males and 14 females, were collected during a course of vertebrate pest control in the Bushehr Province, southwestern Iran in 2013. The specimen were immediately dissected and carefully searched for the parasites. During necropsy, each organ was examined macroscopically for presence of any helminthic agents. Tissue samples were taken from each organ. Moreover, samples were taken from the content of digestive system. Blood samples were also collected from each boar. All the samples were evaluated for helminth infections by parasitological methods. Results: Twenty-two (88%) of the wild boars were infected with at least one helminth. Out of 25 wild boars, 1 (4%) were infected with Cysticercus tenuicollis, the larval stage of Taenia hydatigena, 13 (52%) with Macracanthorhynchus hirudinaceus, 17 (68%) with Metastrongylus spp, and 20 (80%) with Ascarops spp. Hydatid cyst was detected in the lung of one of the wild boars. No Trichinella spp. larvae were detected in any of the tissues of the animals when evaluated by artificial digestion method. In addition, no contamination with microfilaria was detected in any of animals when the blood samples were tested with Knott’s method. Conclusion: Wild boars are contaminated by some helminthes including zoonotic ones. These animals could be involved in the epidemiology of zoonotic helminth by acting as reservoir hosts. This in turn may bring potential risk for locals and residents of the Bushehr Province, Southwestern Iran. PMID:28127344

  5. Juvenile domestic pigs (Sus scrofa domestica) use human-given cues in an object choice task.

    PubMed

    Nawroth, Christian; Ebersbach, Mirjam; von Borell, Eberhard

    2014-05-01

    Research on the comprehension of human-given cues by domesticated as well as non-domesticated species has received considerable attention over the last decade. While several species seem to be capable of utilizing these cues, former work with domestic pigs (Sus scrofa domestica) has shown inconclusive results. In this study, we investigated the use of human-given cues in an object choice task by young domestic pigs (N = 17; 7 weeks of age) who had very limited human contact prior to the experiments. Subjects had to choose between two bowls of which only one was baited with a reward. Over the course of five experiments, pigs were able to use proximal and, with some constraints, also distal pointing cues presented in both a dynamic-sustained and in a momentary manner. When the experimenter was pointing from the incorrect bowl towards the correct one, most of the subjects had problems solving the task-indicating that some form of stimulus/local enhancement affected pigs' decision making. Interestingly, pigs were able to utilize the body and head orientation of a human experimenter to locate the hidden reward but failed to co-orient when head or body orientation of the experimenter was directed into distant space with no bowls present. Control trials ruled out the possibility that other factors (e.g. odour cues) affected subjects' choice behaviour. Learning during experiments played a minor role and only occurred in three out of twelve test conditions. We conclude that domestic pigs, even at a very young age, are skilful in utilizing various human-given cues in an object choice task-raising the question whether pigs only used stimulus/local enhancement and associative learning processes or whether they were able to comprehend the communicative nature of at least some of these cues.

  6. Characterization of Sus scrofa small non-coding RNAs present in both female and male gonads.

    PubMed

    Kowalczykiewicz, Dorota; Świercz, Aleksandra; Handschuh, Luiza; Leśniak, Katarzyna; Figlerowicz, Marek; Wrzesinski, Jan

    2014-01-01

    Small non-coding RNAs (sncRNAs) are indispensable for proper germ cell development, emphasizing the need for greater elucidation of the mechanisms of germline development and regulation of this process by sncRNAs. We used deep sequencing to characterize three families of small non-coding RNAs (piRNAs, miRNAs, and tRFs) present in Sus scrofa gonads and focused on the small RNA fraction present in both male and female gonads. Although similar numbers of reads were obtained from both types of gonads, the number of unique RNA sequences in the ovaries was several times lower. Of the sequences detected in the testes, 2.6% of piRNAs, 9% of miRNAs, and 10% of tRFs were also present in the ovaries. Notably, the majority of the shared piRNAs mapped to ribosomal RNAs and were derived from clustered loci. In addition, the most abundant miRNAs present in the ovaries and testes are conserved and are involved in many biological processes such as the regulation of homeobox genes, the control of cell proliferation, and carcinogenesis. Unexpectedly, we detected a novel sncRNA type, the tRFs, which are 30-36-nt RNA fragments derived from tRNA molecules, in gonads. Analysis of S. scrofa piRNAs show that testes specific piRNAs are biased for 5' uracil but both testes and ovaries specific piRNAs are not biased for adenine at the 10th nucleotide position. These observations indicate that adult porcine piRNAs are predominantly produced by a primary processing pathway or other mechanisms and secondary piRNAs generated by ping-pong mechanism are absent.

  7. Vaccination of pigs reduces Torque teno sus virus viremia during natural infection.

    PubMed

    Jiménez-Melsió, Alexandra; Rodriguez, Fernando; Darji, Ayub; Segalés, Joaquim; Cornelissen-Keijsers, Vivian; van den Born, Erwin; Kekarainen, Tuija

    2015-07-09

    Anelloviruses are a group of single-stranded circular DNA viruses infecting several vertebrate species. Four species have been found to infect swine, namely Torque teno sus virus (TTSuV) 1a and 1b (TTSuV1a, TTSuV1b; genus Iotatorquevirus), TTSuVk2a and TTSuVk2b (genus Kappatorquevirus). TTSuV infection in pigs is distributed worldwide, and is characterized by a persistent viremia. However, the real impact, if any, on the pig health is still under debate. In the present study, the impact of pig immunization on TTSuVk2a loads was evaluated. For this, three-week old conventional pigs were primed with DNA vaccines encoding the ORF2 gene and the ORF1-A, ORF1-B, and ORF1-C splicing variants and boosted with purified ORF1-A and ORF2 Escherichia coli proteins, while another group served as unvaccinated control animals, and the viral load dynamics during natural infection was observed. Immunization led to delayed onset of TTSuVk2a infection and at the end of the study when the animals were 15 weeks of age, a number of animals in the immunized group had cleared the TTSuVk2a viremia, which was not the case in the control group. This study demonstrated for the first time that TTSuV viremia can be controlled by a combined DNA and protein immunization, especially apparent two weeks after the first DNA immunization before seroconversion was observed. Further studies are needed to understand the mechanisms behind this and its impact for pig producers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Genetic structure of wild boar (Sus scrofa) populations from East Asia based on microsatellite loci analyses

    PubMed Central

    2014-01-01

    Background Wild boar, Sus scrofa, is an extant wild ancestor of the domestic pig as an agro-economically important mammal. Wild boar has a worldwide distribution with its geographic origin in Southeast Asia, but genetic diversity and genetic structure of wild boar in East Asia are poorly understood. To characterize the pattern and amount of genetic variation and population structure of wild boar in East Asia, we genotyped and analyzed microsatellite loci for a total of 238 wild boar specimens from ten locations across six countries in East and Southeast Asia. Results Our data indicated that wild boar populations in East Asia are genetically diverse and structured, showing a significant correlation of genetic distance with geographic distance and implying a low level of gene flow at a regional scale. Bayesian-based clustering analysis was indicative of seven inferred genetic clusters in which wild boars in East Asia are geographically structured. The level of genetic diversity was relatively high in wild boars from Southeast Asia, compared with those from Northeast Asia. This gradient pattern of genetic diversity is consistent with an assumed ancestral population of wild boar in Southeast Asia. Genetic evidences from a relationship tree and structure analysis suggest that wild boar in Jeju Island, South Korea have a distinct genetic background from those in mainland Korea. Conclusions Our results reveal a diverse pattern of genetic diversity and the existence of genetic differentiation among wild boar populations inhabiting East Asia. This study highlights the potential contribution of genetic variation of wild boar to the high genetic diversity of local domestic pigs during domestication in East Asia. PMID:25034725

  9. Survey for selected pathogens in wild pigs (Sus scrofa) from Guam, Marianna Islands, USA.

    PubMed

    Cleveland, Christopher A; DeNicola, Anthony; Dubey, J P; Hill, Dolores E; Berghaus, Roy D; Yabsley, Michael J

    2017-06-01

    Pigs (Sus scrofa) were introduced to Guam in the 1600's and are now present in high densities throughout the island. Wild pigs are reservoirs for pathogens of concern to domestic animals and humans. Exposure to porcine parvovirus, transmissible gastroenteritis, and Leptospira interrogans has been documented in domestic swine but data from wild pigs are lacking. The close proximity of humans, domestic animals, and wild pigs, combined with the liberal hunting of wild pigs, results in frequent opportunities for pathogen transmission. From February-March 2015, blood, tissue and ectoparasite samples were collected from 47 wild pigs. Serologic testing found exposure to Brucella spp. (2%), Toxoplasma gondii (11%), porcine reproductive and respiratory syndrome (PRRS) virus (13%), porcine circovirus type 2 (36%), pseudorabies virus (64%), Actinobacillus pleuropneumoniae (93%), Lawsonia intracellularis (93%), and porcine parvovirus (94%). Eleven (24%) samples had low titers (1:100) to Leptospira interrogans serovars Bratislava (n=6), Icterohaemorrhagiae (n=6), Pomona (n=2), and Hardjo (n=1). Kidney samples from nine pigs with Leptospira antibodies were negative for Leptospira antigens. Numerous pigs had Metastrongylus lungworms and three had Stephanurus dentatus. Lice (Hematopinus suis) and ticks (Amblyomma breviscutatum) were also detected. No antibodies to Influenza A viruses were detected. In contrast to the previous domestic swine survey, we found evidence of numerous pathogens in wild pigs including new reports of pseudorabies virus, PRRS virus, Brucella, and Leptospira in pigs on Guam. These findings highlight that domestic swine-wild pig interactions should be prevented and precautions are needed when handling wild pigs to minimize the risk of pathogen transmission. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Seasonal effect on sperm messenger RNA profile of domestic swine (Sus Scrofa).

    PubMed

    Yang, C C; Lin, Y S; Hsu, C C; Tsai, M H; Wu, S C; Cheng, W T K

    2010-05-01

    Seasonal infertility is a well-known problem in the modern swine (Sus scrofa) industry. The molecular mechanisms responsible for thermal effects on spermatogenesis are, however, just beginning to be elucidated. The existence of specific messenger RNA (mRNA) remnants contained within freshly ejaculated sperm has been identified in several species. Investigators have obtained differential RNA profiles of infertile men compared with fertile individuals; however, there are limited to the probes, which are mostly derived from nucleic acids of testicular tissues of either human or mice. The objective of this study was to investigate mRNA remnants from ejaculated sperm of the domestic swine and uncover important clues regarding the molecular regulation of spermatogenesis under environmental thermo-impacts. We utilized the remnant mRNA collected from swine ejaculated sperm as the target source to detect the global gene expression in summer and in winter by swine sperm-specific oligonucleotide microarray. Sixty-seven transcripts were differentially expressed with statistical differences between seasons of sperm samples collected, including forty-nine in winter (49/67) and eighteen in summer (18/67). There were only 33 of these transcripts that could be annotated to gene ontology hierarchy with the database of Homo sapiens and their functions mostly were involved in variety of metabolic processes. Moreover, these studies also confirmed that significant differences of gene expression profiles were found in swine sperm when comparisons were made between ejaculates collected during the winter and the summer season under the subtropical area such as Taiwan. Even though most of the genes found in our experiments are still poorly understood in terms of their true functions in spermatogenesis, bioinformatics analysis suggested that they are involved in a broad spectrum of biochemical processes including gamete generation. These concordant profiles should permit the development of a

  11. Alkali-labile sites in sperm cells from Sus and Ovis species.

    PubMed

    Cortés-Gutiérrez, Elva I; Dávila-Rodríguez, Martha I; López-Fernández, Carmen; Fernández, José Luis; Gosálvez, Jaime

    2008-06-01

    Constitutive alkali-labile sites (ALSs) have been investigated using a protocol of DNA breakage detection-fluorescence in situ hybridization (DBD-FISH) in sperm cells from Sus domesticus (pig), Ovis gmelini musimon (mouflon) and Ovis aries (sheep). The results were compared with those obtained using leucocytes from the same species. Whole comparative genomic hybridization (W-CGH) showed that most of the constitutive ALSs in somatic and germ line cells in all species examined were constrained to particular repetitive satellite DNA sequences located in the pericentromeric constitutive heterochromatin of each chromosome. However, their relative abundance was different among cells of the same organism (leucocytes/sperm cells), and this trend was not maintained when the different species were compared. Thus, in mouflon, the density of ALSs in leucocytes when compared with that observed in sperm cells indicated abundance of the order of eight times less. In sheep, both leucocytes and sperm cells exhibited a large quantity of ALSs, being of the order of four times more abundant in sperm cells. In the pig genome, leucocytes showed a high abundance of ALSs (of the order of 12 times more that in sperm cells) but only involved the metacentric chromosomes of the karyotype. ALSs were not present in the acrocentric chromosomes. Contrary to mouflon and sheep, ALSs were relatively scarce in sperm cells from pig. These results suggest that ALSs are a transient structural feature in the cells of any organisms and point to a non-universal model of chromatin organization in sperm cells among mammals.

  12. The nuclear DNA longevity in cryopreserved boar spermatozoa assessed using the Sperm-Sus-Halomax.

    PubMed

    Alkmin, Diego V; Martinez-Alborcia, Maria J; Parrilla, Inmaculada; Vazquez, Juan M; Martinez, Emilio A; Roca, Jordi

    2013-06-01

    The aim of this experimental study was to evaluate the dynamics of nuclear DNA fragmentation in frozen-thawed (FT) boar spermatozoa incubated over time. Using the Sperm Chromatin Dispersion test (Sperm-Sus-Halomax), this study focused special attention on resolving the hypothesis that the original halo shapes around the sperm head could show dynamic changes over the postthawing incubation time. Twenty FT sperm samples from five boars (four per boar) were incubated at 37 °C during 168 hours and sperm motility (assessed using computer-assisted sperm analysis), viability (evaluated using the LIVE/DEAD Sperm Viability Kit), and nuclear DNA fragmentation were analyzed at 0, 0.5, 2, 4, 6, 24, 48, 72, and 168 hours. The percentages of motile and viable spermatozoa progressively decreased during incubation, with no motile and viable spermatozoa less than 10% in all boars at 24 hours of incubation. Four different halo shapes around the sperm head were considered in the Sperm Chromatin Dispersion test: normal, small, large scattered (typical fragmented nuclear DNA), and absent halo, all of them coexisting at the same time in the boar FT semen samples. Sperm with a large scattered halo did not change during postthaw, consistently showing percentages less than 5% over time in all boars. In contrast, the other three sperm populations showed a dynamic evolution over incubation time, characterized by a gradual reduction of sperm with normal halo, proportional to the increment in the sperm showing a small halo, followed by a switch between the sperm with a small halo and sperm with no halo. These results suggest that three of these four sperm populations, those showing small, large scattered, and absent halo, represent spermatozoa with different degrees of nuclear DNA damage, which should be taken into consideration to indicate the percentage of sperm with fragmented nuclear DNA in boar FT semen samples.

  13. Experimental ex vivo traumatic intrusion in the mandibular incisors of the farm pig, Sus scrofa.

    PubMed

    Patterson, Amanda; Popowics, Tracy

    2014-12-01

    Traumatic intrusion of incisor teeth occurs frequently in young children, as well as in teens and adults; however, the biological mechanisms promoting negative sequelae or recovery are not well understood (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:493 and Vital Health Stat 11 2007;248:1). Modeling intrusive trauma and post-traumatic healing in an animal model offers the opportunity to define these biological mechanisms and to inform the design of treatments. The objective of this study was to investigate the pig, Sus scrofa, as a model for intrusive trauma, using an in vitro approach. Mandibular segments from ex vivo farm pigs were bisected and primary central incisors were prepared to either receive axial traumatic loads or to serve as non-intruded controls. A class 2 lever modeled traumatic impact to the incisors. Damage to the periodontal support in intruded and control specimens (n = 10) was evaluated through compression testing and comparison of elastic moduli. Incisor displacement was measured on X-ray images taken before and after trauma, and following compressive tests. Lingual x-rays showed a mean postinjury displacement of the incisor root of 3.81 ± 1.87 mm. With compression testing, the root length embedded in bone increased in traumatized and non-traumatized teeth by 2.9 mm and 0.81 mm, respectively (P = 0.03). The intrusion group Young's modulus was significantly lower than the control group (4452 vs 7704 Mpa; P = 0.05). In vitro modeling of traumatic intrusion resulted in damage to the periodontal support of central incisors and axial tooth displacement. Pig incisors offer an important model for further study of incisor trauma. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Clean Technique for Prolonged Nonsurvival Cardiothoracic Surgery in Swine (Sus scrofa)

    PubMed Central

    Chan, Maia M; Rabkin, David G; Washington, Ida M

    2013-01-01

    Laboratory animal regulations provide little guidance regarding duration of nonsurvival surgery requiring aseptic technique. We hypothesized that swine would experience no sepsis during nonsurvival cardiothoracic surgery accomplished by using clean technique and lasting 8 h or less. Incision sites of 5 male farm pigs (Sus scrofa) were shaved and then cleaned with alcohol and povidone–iodine. The surgeon wore sterile gloves, clean scrubs, and hair bonnet; assistants wore clean scrubs and nonsterile gloves; most instruments were autoclaved. A median sternotomy incision was used for thoracic cavity exposure, and the skull was exposed to allow induction of brain death. Heart rate, body temperature, and blood samples were obtained before surgery (0 h; baseline) and at 2, 4, 5 or 6, and 7 or 8 h thereafter. Statistical analysis by t tests showed that heart rate was unchanged and body temperature increased after the 0-h (baseline) time point. Aerobic blood cultures were negative except for 2 samples that were positive for coagulase-negative Staphylococcus spp. at 4 h. RBC, Hgb, and Hct levels were decreased at 2 and 4 h, but WBC and platelets were unchanged. Other alterations included decreased glucose (at 7 or 8 h), increased BUN (at 5 or 6 h and 7 or 8 h) and creatinine (at 5 or 6 h), decreased Na+ and Ca and increased K+ (most time points), decreased total protein and albumin (most time points), and decreased globulin (at 7 or 8 h). Liver enzymes and bilirubin typically were unchanged, and cholesterol consistently was decreased. Together our results indicate a lack of sepsis for 8 h or less in pigs undergoing cardiothoracic surgery by using clean technique. These findings provide new and specific data regarding the use of aseptic technique during prolonged nonsurvival surgeries. PMID:23562035

  15. The Effects of Tooth Extraction on Alveolar Bone Biomechanics in the Miniature Pig, Sus scrofa

    PubMed Central

    Yeh, K.; Popowics, T.; Rafferty, K.; Herring, S.; Egbert, M.

    2010-01-01

    Objective This study investigated the role of occlusion in the development of biomechanical properties of alveolar bone in the miniature pig, Sus scrofa. The hypothesis tested was that the tissues supporting an occluding tooth would show greater stiffness and less strain than that of a non-occluding tooth. Design Maxillary teeth opposing the erupting lower first molar (M1) were extracted on one side. Occlusion developed on the contralateral side. Serially administered fluorochrome labels tracked bone mineralization apposition rate (MAR). A terminal experiment measured in vivo buccal alveolar bone strain on occluding and non-occluding sides during mastication. Ex vivo alveolar strains during occlusal loading were subsequently measured using a materials testing machine (MTS/Sintech). Whole specimen stiffness and principal strains were calculated. Results MAR tended to be higher on the extraction side during occlusion. In vivo buccal shear strains were higher in the alveolar bone of the occluding side vs. the extraction side (mean of 471με vs. 281με, respectively; p=0.04); however, ex vivo shear strains showed no significant differences between sides. Stiffness differed between extraction and occlusion side specimens, significantly so in the low load range (344 vs. 668MPa, respectively; p=0.04). Conclusions Greater in vivo shear strains may indicate more forceful chews on the occluding side, whereas the similarity in ex vivo bone strain magnitude suggests a similarity in alveolar bone structure and occlusal load transmission regardless of occlusal status. The big overall change in specimen stiffness that was observed was likely attributable to differences in the periodontal ligament rather than alveolar bone. PMID:20580345

  16. Overexpression of the tomato pollen receptor kinase LePRK1 rewires pollen tube growth to a blebbling mode

    USDA-ARS?s Scientific Manuscript database

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP...

  17. Specific role of LeMAN2 in the control of seed germination exposed by overexpression of the LeMAN3 gene in tomato plants.

    PubMed

    Belotserkovsky, Harel; Berger, Yael; Shahar, Ron; Wolf, Shmuel

    2007-12-01

    Endo-beta-mannanase is one of the key enzymes involved in the hydrolysis of the mannan-rich cell walls of tomato (Solanum lycopersicon) seeds. Two isoforms of endo-beta-mannanase have been characterized in tomato seeds: LeMAN2 is active in the micropylar area prior to germination and LeMAN1 is active after germination in all endosperm cells surrounding the cotyledons. To explore whether general mannanase activity in the endosperm cap is sufficient to promote germination, the gene encoding LeMAN3 was inserted into transgenic tomato plants under the control of a CaMV-35S promoter. Expression of LeMAN3 was evident in the endosperm cap and in the lateral endosperm of the transgenic seeds 10 min after imbibition. An activity test indicated increased activity of endo-beta-mannanase in the transgenic lines relative to the control line in all seed parts, during the first 20 h of imbibition. However, overexpression of LeMAN3 in transgenic seeds inhibited seed germination at both optimal and suboptimal temperatures. Detailed RT-PCR analyses revealed the transcription patterns of the genes encoding the various mannanase isoforms, and indicated a delay in LeMAN2 transcription in the endosperm cap of the transgenic seeds. Interestingly, tissue-print assays indicated similar mannanase activity in the micropylar areas for both transgenic and control seeds. These results indicate that overexpression of active endo-beta-mannanase in the endosperm cap is not sufficient to enable hydrolysis of the cell walls or to promote germination of tomato seeds. Cell-wall hydrolysis in these endosperm cells is under tight control and requires the specific activity of LeMAN2.

  18. Spondylodiscite granulomateuse: surtout la tuberculose mais ne pas omettre le lymphome

    PubMed Central

    Zinebi, Ali; Rkiouak, Adil; Akhouad, Yousef; Reggad, Ahmed; Kasmy, Zohour; Boudlal, Mostafa; Lho, Abdelhamid Nait; Rabhi, Moncef; Sinaa, Mohamed; Ennibi, Khalid; Chaari, Jilali

    2016-01-01

    Les douleurs lombaires relèvent d'étiologies multiples dont le diagnostic peut être source de grandes difficultés. Le lymphome rachidien primitif est rare et son diagnostic nécessite une biopsie souvent scanoguidée. Un homme de 30 ans, était hospitalisé pour lombalgies inflammatoires évoluant dans un contexte d'altération de l'état général avec à l'examen des douleurs à la palpation des apophyses épineux L2L3, sans syndrome tumoral périphérique. Le bilan biologique montrait un syndrome inflammatoire. Le bilan morphologique était en faveur d'une spondylodiscite. La première biopsie montrait une ostéite granulomateuse. L'aggravation clinique et radiologique sous anti bacillaire a mené à reconsidérer le diagnostic et la deuxième biopsie confirme le diagnostic du lymphome. Le diagnostic de tuberculose osseuse en particulier vertébrale nécessite une confirmation bactériologique et ou histologique pour ne pas méconnaître un lymphome osseux primitif. PMID:28292061

  19. Le nodule nécrotique solitaire du foie: à propos de deux cas

    PubMed Central

    Mzoughi, Zeineb; Slama, Sana Ben; Bacha, Dhouha; Romdhane, Haifa; Bayar, Rached; Sassi, Asma; Lahmar, Ahlem

    2016-01-01

    Les lésions hépatiques nodulaires sont majoritairement tumorales. Le nodule nécrotique solitire du foie est rare. Le diagnostic preopératoire est difficile. Il s'agit d'une femme âgée de 43 ans qui était opérée d'un adénocarcinome du rectum métastatique au foie opéré. Le scanner abdominal de surveillance a révélé un nodule hépatique d'allure métastatique. Le second cas est celui d'un homme de 56 ans, admis pour cholécystectomie avec découverte per-opératoire d'un nodule hépatique. Dans les deux cas, le nodule hépatique était sous capsulaire et a été réséqué. L'examen anatomopathologique posait le diagnostic de nodule nécrotique solitaire du foie. Le nodule nécrotique non spécifique du foie est une lésion qui doit être évoquée, même dans un contexte néoplasique. Une caractérisation par l'imagerie et une ponction biopsie des lésions hépatiques peut être utile. PMID:28292145

  20. Cyclic oxidation of Mn-Co spinel coated SUS 430 alloy in the cathodic atmosphere of solid oxide fuel cells

    NASA Astrophysics Data System (ADS)

    Hua, Bin; Pu, Jian; Gong, Wei; Zhang, Jianfu; Lu, Fengshuang; Jian, Li

    In order to improve oxidation resistance and long-term stability of the metallic interconnects and prevent the cathode of solid oxide fuel cells (SOFCs) from Cr-poisoning, an effective, relatively dense and well adherent Mn-Co spinel protection coating with a nominal composition of MnCo 2O 4 is applied onto the surfaces of the SUS 430 ferritic stainless steel by a cost-effective sol-gel process. The long-term thermally cyclic oxidation kinetics and oxide scale structures as well as the composition of the coated SUS 430 alloy are investigated. The Mn-Co spinel protection layer demonstrates an excellent structural and thermomechanical stability, and effectively acts as a mass barrier to the outward diffusion of cations, especially Cr, and a lowered parabolic rate constant of k p = 1.951 × 10 -15 g 2 cm -4 s -1 is obtained.

  1. Cross-Reactivity of Porcine Immunoglobulin A Antibodies with Fecal Immunoglobulins of Wild Boar (Sus scrofa) and Other Animal Species

    PubMed Central

    Seo, Sang won; Yoo, Sung J.; Sunwoo, Sunyoung; Hyun, Bang hun

    2016-01-01

    Fecal samples obtained from wild boar habitats are useful for the surveillance of diseases in wild boar populations; however, it is difficult to determine the species of origin of feces collected in natural habitats. In this study, a fecal IgA ELISA was evaluated as a method for identifying the porcine species from fecal samples. Both domestic pigs (Sus scrofa domestica) and wild boars (Sus scrofa coreanus) showed significantly higher levels of fecal IgA than other animal species. Additionally, age dependent changes in the level of Ig A in wild boars and domestic pigs were identified; Titers of Ig A were highest in suckling period and lowest in weanling period. PMID:27340389

  2. Correlation analysis of human embryo Le(Y) glycan antigen expression and embryo quality.

    PubMed

    Gu, Juan; Sui, Linlin; Ma, Yanni; Guo, Zhenzhen; Zhang, Man; Zhu, Chenyang; Cai, Zhu; Kong, Ying

    2017-07-01

    This study assessed the feasibility of using Le(Y) glycan secretion level in human embryos as a method of judging embryo quality. Embryo culture media from patients receiving in vitro fertilization-embryo transfer was collected, and quality scores of embryos were recorded. Secretions of Le(Y) in the culture media in different development stages (from 4-cell to 10-cell), embryos in the same development stage of the same patients (8-cell/I) and embryos in the same development stage of different patients (8-cell/I) were examined by dot-blot. Embryos were divided into a hypersecretion group and hyposecretion group, based on their Le(Y) secretion level. The embryo quality was evaluated by clinical observations, the number which developed to D3 cell stage and the number of successful embryo transplantations. Le(Y) secretion increased as embryos developed from 4-cell to 10-cell (P<0.05); secretion of Le(Y) of 8/I is not identical; development speed of embryos with different secretion level of Le(Y) was also different. The number of embryos which developed to 6-cell or higher was 82.2% in the Le(Y) hypersecretion group but only 60% in the hyposecretion group. The rate of successful transplantation was significantly higher in the hypersecretion group (71.1 vs. 40%). In conclusion, Le(Y) glycan secretion level in human embryos is closely related to embryo quality. Le(Y) may become a useful measure to evaluate embryo quality in the future.

  3. Sodium Thiosulfate Versus Hydroxocobalamin in the Treatment of Acute, Severe Cyanide Induced Cardiotoxicity in a Swine (Sus Scrofa) Model

    DTIC Science & Technology

    2011-09-22

    intoxicated by cyanide develop cardiac-ar.rest or severely low blood pressure. Currently several antidotes exist, but many have severe adverse effects...machine. They were intoxicated with cyanide (infused through the vein) until the blood pressure was low. The animals were assigned to-one of three...IUIVIJ:lt:M Sodium thiosulfate versus hydroxocoba~amin in the treatment of acute, severe cyanide induced cardiotoxicity in a swine (Sus Scrofa)model on

  4. Speech Processing in Realistic Battlefield Environments (Le Traitement de la Parole en Environnement de Combat Realiste)

    DTIC Science & Technology

    2009-04-01

    parole et du langage multilingue commence à être reconnue comme un enjeu important par les organisations internationales civiles et militaires. Par...sur le développement et l’évaluation des applications multilingues de la parole et du langage . Pour stimuler la recherche et l’évaluation, le Groupe...Opérationnel de Recherche sur la Parole et le Langage (IST-031/TG-013) de l’OTAN a collationné des données vocales en environnement de combat. Ces

  5. [Prevalence of Giardia duodenalis assemblage B in humans in Zaragoza and León, Spain].

    PubMed

    Goñi, Pilar; Aldana, Débora Esmeralda; Clavel, Antonio; Seral, Cristina; Remacha, María Antonia; Castillo, Francisco Javier

    2010-12-01

    To study Giardia duodenalis assemblages circulating in the health areas of two hospitals in Zaragoza and León (Spain). A total of 211 stool samples with Giardia were genotyped by PCR of the tpi gene. Assemblage B was the most prevalent, both in Zaragoza (84,7%) and León (95,1%). The remaining isolates were identified as AII+B. We detected the spread of G. duodenalis assemblage B in Zaragoza and in León, with an increase in its prevalence in Zaragoza compared to previous studies. Copyright © 2009 Elsevier España, S.L. All rights reserved.

  6. Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania.

    PubMed

    Larson, Greger; Cucchi, Thomas; Fujita, Masakatsu; Matisoo-Smith, Elizabeth; Robins, Judith; Anderson, Atholl; Rolett, Barry; Spriggs, Matthew; Dolman, Gaynor; Kim, Tae-Hun; Thuy, Nguyen Thi Dieu; Randi, Ettore; Doherty, Moira; Due, Rokus Awe; Bollt, Robert; Djubiantono, Tony; Griffin, Bion; Intoh, Michiko; Keane, Emile; Kirch, Patrick; Li, Kuang-Ti; Morwood, Michael; Pedriña, Lolita M; Piper, Philip J; Rabett, Ryan J; Shooter, Peter; Van den Bergh, Gert; West, Eric; Wickler, Stephen; Yuan, Jing; Cooper, Alan; Dobney, Keith

    2007-03-20

    Human settlement of Oceania marked the culmination of a global colonization process that began when humans first left Africa at least 90,000 years ago. The precise origins and dispersal routes of the Austronesian peoples and the associated Lapita culture remain contentious, and numerous disparate models of dispersal (based primarily on linguistic, genetic, and archeological data) have been proposed. Here, through the use of mtDNA from 781 modern and ancient Sus specimens, we provide evidence for an early human-mediated translocation of the Sulawesi warty pig (Sus celebensis) to Flores and Timor and two later separate human-mediated dispersals of domestic pig (Sus scrofa) through Island Southeast Asia into Oceania. Of the later dispersal routes, one is unequivocally associated with the Neolithic (Lapita) and later Polynesian migrations and links modern and archeological Javan, Sumatran, Wallacean, and Oceanic pigs with mainland Southeast Asian S. scrofa. Archeological and genetic evidence shows these pigs were certainly introduced to islands east of the Wallace Line, including New Guinea, and that so-called "wild" pigs within this region are most likely feral descendants of domestic pigs introduced by early agriculturalists. The other later pig dispersal links mainland East Asian pigs to western Micronesia, Taiwan, and the Philippines. These results provide important data with which to test current models for human dispersal in the region.

  7. [Identification and characterization of intraspecific variability of the sucrose synthase gene Sus4 of potato (Solanum tuberosum)].

    PubMed

    Boris, K V; Ryzhova, N N; Kochieva, E Z

    2011-02-01

    Nucleotide and amino acid variability of fragments of the Sus4 gene encoding the sucrose synthase enzyme was studied in 24 potato cultivars selected in Russia and other countries and differing in starch content in tubers. Both SNPs and indels were detected in a chosen Sus4 gene fragment including the sequence from exon 3 to exon 6 and corresponding to the main part of the sucrose synthase domain. Four types of Sus4 sequences were revealed depending on the presence of an insertion in introns 4 and 5 and of the mononucleotide octamer (T)8 in intron 5. Differentiation of these sequences was confirmed by statistical methods. Sixteen amino acid substitutions were identified in the translated sequence, of which eleven were nonsynonymous. Specific varietal nucleotide and amino acid substitutions were also revealed, which can be used in future for marking potato cultivars/genotypes. No direct associations between the mutational changes and the starch content were found in the potato cultivars studied by us.

  8. Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania

    PubMed Central

    Larson, Greger; Cucchi, Thomas; Fujita, Masakatsu; Matisoo-Smith, Elizabeth; Robins, Judith; Anderson, Atholl; Rolett, Barry; Spriggs, Matthew; Dolman, Gaynor; Kim, Tae-Hun; Thuy, Nguyen Thi Dieu; Randi, Ettore; Doherty, Moira; Due, Rokus Awe; Bollt, Robert; Djubiantono, Tony; Griffin, Bion; Intoh, Michiko; Keane, Emile; Kirch, Patrick; Li, Kuang-Ti; Morwood, Michael; Pedriña, Lolita M.; Piper, Philip J.; Rabett, Ryan J.; Shooter, Peter; Van den Bergh, Gert; West, Eric; Wickler, Stephen; Yuan, Jing; Cooper, Alan; Dobney, Keith

    2007-01-01

    Human settlement of Oceania marked the culmination of a global colonization process that began when humans first left Africa at least 90,000 years ago. The precise origins and dispersal routes of the Austronesian peoples and the associated Lapita culture remain contentious, and numerous disparate models of dispersal (based primarily on linguistic, genetic, and archeological data) have been proposed. Here, through the use of mtDNA from 781 modern and ancient Sus specimens, we provide evidence for an early human-mediated translocation of the Sulawesi warty pig (Sus celebensis) to Flores and Timor and two later separate human-mediated dispersals of domestic pig (Sus scrofa) through Island Southeast Asia into Oceania. Of the later dispersal routes, one is unequivocally associated with the Neolithic (Lapita) and later Polynesian migrations and links modern and archeological Javan, Sumatran, Wallacean, and Oceanic pigs with mainland Southeast Asian S. scrofa. Archeological and genetic evidence shows these pigs were certainly introduced to islands east of the Wallace Line, including New Guinea, and that so-called “wild” pigs within this region are most likely feral descendants of domestic pigs introduced by early agriculturalists. The other later pig dispersal links mainland East Asian pigs to western Micronesia, Taiwan, and the Philippines. These results provide important data with which to test current models for human dispersal in the region. PMID:17360400

  9. Exploring PTX3 expression in Sus scrofa cardiac tissue using RNA sequencing.

    PubMed

    Cabiati, Manuela; Caselli, Chiara; Savelli, Sara; Prescimone, Tommaso; Lionetti, Vincenzo; Giannessi, Daniela; Del Ry, Silvia

    2012-02-10

    The prototypic long pentraxin PTX3 is a novel vascular inflammatory marker sharing similarities with the classic short pentraxin (C-reactive protein). PTX3 is rapidly produced and released by several cell types in response to local inflammation of the cardiovascular system. Plasma PTX3 levels are very low in normal conditions and increase in heart failure (HF) patients with advancing NYHA functional class, but its exact role during HF pathogenetic mechanisms is not yet established. No data about PTX3 cardiac expression in normal and pathological conditions are currently available, either in human or in large-size animals. Of the latter, the pig has a central role in "in vivo" clinical settings but its genome has not been completely sequenced and the PTX3 gene sequence is still lacking. The aim of this study was to sequence the PTX3 in Sus scrofa, whose sequence is not yet present in GenBank. Utilizing our knowledge of this sequence, PTX3 mRNA expression was evaluated in cardiac tissue of normal (n=6) and HF pigs (n=5), obtained from the four chambers. To sequence PTX3 gene in S. scrofa, the high homology between Homo sapiens and S. scrofa was exploited. Pig PTX3 mRNA was sequenced using polymerase chain reaction primers designed from human consensus sequences. The DNA, obtained from different RT-PCR reactions, was sequenced using the Sanger method. S. scrofa PTX3 mRNA, 1-336 bp, was submitted to GenBank (ID: GQ412351). The sequence obtained from pig cardiac tissue shared an 84% sequence identity with human homolog. The presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls (p=0.036 HF right atrium vs. N; p=0.022, HF left ventricle vs. N). Knowledge of the PTX3 sequence could be a useful starting point for future studies devoted to better understanding the specific role of this molecule in the pathogenesis of cardiovascular diseases.

  10. Portevin-Le Chatelier effect and Tsallis nonextensive statistics

    NASA Astrophysics Data System (ADS)

    Iliopoulos, A. C.; Nikolaidis, N. S.; Aifantis, E. C.

    2015-11-01

    In this paper, we estimate Tsallis' entropic index q ≡qstat (stat denotes stationary states) for various stress serration time series of Cu-15%Al alloys corresponding to different deformation temperatures and types (A, B, C) of Portevin-Le Chatelier (PLC) bands. Tsallis statistical analysis is also conducted on experimental data derived from correlation diagrams focusing on PLC type C bands' spatial organization at the surface of various specimens. The results concerning the stress serrations analysis reveal the non-Gaussian (Tsallis q-Gaussian), nonextensive, sub-additive, character of the underlying dynamics of the PLC type-A bands (q > 1) indicating dynamics at the edge of chaos, with global long range correlations and power law scaling. Similarly, for PLC type B bands, a Tsallis q-Gaussian, non-extensive, super-additive, statistical profile was found with q < 1, while for the PLC type C bands, a near Boltzmann-Gibbs (BG) statistical character was verified indicating Gaussian dynamics with short (weak) range correlations. Finally, Tsallis q-index for the spatial data of PLC type C bands was found above unity (q > 1) indicating that type C bands are not randomly nucleated in the specimen (e.g. yielding a Gaussian distribution) but there exist spatial coupling and long range deformation correlations in the PLC type C bands spatial localization.

  11. LeFort III advancement with and without osteogenesis distraction.

    PubMed

    Iannetti, Giorgio; Fadda, Teresa; Agrillo, Alessandro; Poladas, Giulio; Iannetti, G; Filiaci, Fabio

    2006-05-01

    The LeFort III osteotomy is the surgical treatment performed in patients with mid-facial retrusions in craniofacial dysostoses such as Crouzon, Apert, Pfeiffer syndromes, etc. The first authors to report the accomplishment of this osteotomy were Gillies and Harrison in 1951, this technique was then resumed and improved by Tessier in 1967, who made five different variants mainly regarding the typology of the osteotomy concerning the lateral wall of the orbit. Recently, distraction techniques have been applied to the upper mid-face which foresees a gradual advancement of the mid-face through the osteogenetic distraction procedure. The purpose of this retrospective clinical outcome study is to evaluate and compare the two different surgical techniques through the experience acquired during the treatment of 15 cases of craniofacial dysostoses from 1990-2005, and through international literature. The standard surgery technique was performed in 5 of these patients, whereas the osteogenetic distraction technique was performed in the remaining 10. All patients were studied preoperatively through the acquisition of photographic images, cephalometric analysis of the skull, and the study on plaster models of the occlusion of the dental arches. The instrumental exams required before surgery are the following: telecranium X-rays in two projections, orthopanoramic X-rays, CT. The results of this study indicate that the osteodistraction technique represents the choice treatment in severe retrusions of the mid-face while the traditional surgical technique remains indicated in adult patients that are in need of moderate advancements.

  12. [Mr. Wang Le-ting: a master of acupuncture].

    PubMed

    Niu, Xue-Song; Wang, Fan

    2012-11-01

    Mr. WANG Le-ting attaches great importance to accurate differentiation of syndromes, strict selection of acupoints, technique and direction of needle insertion, clear reinforcing and reducing methods after the appearance of needling sensations, proper opportunities of manipulations as well as needle withdrawal techniques, and reasonable application of acupuncture and moxibustion respectively. The above mentioned principles are known as his "5 agreements". He emphasizes that the selection of acupoints should be "in accordance with both the meridians and the accurate location of the points", and "needling sensation is necessary for each point". He holds that the back-shu points of the five-zang organs and Geshu (BL 17) can be adopted for patient with deficiency of qi, blood, yin and yang. In the aspect of acupoint theory, he insists the accurate location of Xuanzhong (GB 39). He also adjusts the locations of Huatuo Jiaji (EX-B 2) points, and finds the location of the new Dubi (ST 35). For easier applications, he divides the functions of acupoints into different schools of qi, blood, cold, heat, deficiency, excess, wind and dampness. And 41 combinations of acupoints are also invented as innovation. He is always strict to his students, instructing and influencing them by his own words and deeds. He is always conscientious and meticulous, which benefit immensely his followers, and remains a lot of precious experiences for the later generations.

  13. [Effects of Le-Fort-I-Osteotomy on nasalance scores].

    PubMed

    Zemann, Wolfgang; Feichtinger, Matthias; Santler, Gert; Kärcher, Hans

    2006-07-01

    Nasalance represents a measure of the relative amount of oral and nasal acoustic energy produced by a speaker. Literature shows changes in nasalance after surgery of the oropharynx. The aim of this prospective study was to evaluate the outcome of speech and nasalance scores after Le-Fort-I-Osteotomy. A total of 20 individuals with normal speech development were examined preoperatively and 6 weeks postoperatively with the Nasometer 6200 (Kay-Elemetrics, USA) after bimaxillary surgery. The tone materials used comprised the standardized text passage: "Ein Kindergeburtstag", the vowels: /a/, /e/, /i/, /o/, /u/ and a syllable repetition subtest. All patients showed changes in nasalance scores 6 weeks postoperatively. There were no significant changes reading the standard text. The syllable repetition test showed significant changes for repetition of "ma ma ma" and "na na na" (p=0,003, respectively p=0,033). Intonation of the vowel /a/1 also revealed significant changes regarding the pre- and postoperative values (p=0,006). However, the obtained values had no significant impact on the nasality characteristics of speech. This study confirms that maxillary osteotomies can result in significant changes of nasalance scores. However these changes do not have any impact on normal speech and voice.

  14. Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice

    PubMed Central

    Hatch, Robert John; Leinenga, Gerhard

    2016-01-01

    Scanning ultrasound (SUS) is a noninvasive approach that has recently been shown to ameliorate histopathological changes and restore memory functions in an Alzheimer's disease mouse model. Although no overt neuronal damage was reported, the short- and long-term effects of SUS on neuronal excitability and dendritic tree morphology had not been investigated. To address this, we performed patch-clamp recordings from hippocampal CA1 pyramidal neurons in wild-type mice 2 and 24 hours after a single SUS treatment, and one week and 3 months after six weekly SUS treatments, including sham treatments as controls. In both treatment regimes, no changes in CA1 neuronal excitability were observed in SUS-treated neurons when compared to sham-treated neurons at any time-point. For the multiple treatment groups, we also determined the dendritic morphology and spine densities of the neurons from which we had recorded. The apical trees of sham-treated neurons were reduced at the 3 month time-point when compared to one week; however, surprisingly, no longitudinal change was detected in the apical dendritic trees of SUS-treated neurons. In contrast, the length and complexity of the basal dendritic trees were not affected by SUS treatment at either time-point. The apical dendritic spine densities were reduced, independent of the treatment group, at 3 months compared to one week. Collectively, these data suggest that ultrasound can be employed to prevent an age-associated loss of dendritic structure without impairing neuronal excitability. PMID:27727310

  15. LeMAPK1, LeMAPK2, and LeMAPK3 are associated with nitric oxide-induced defense response against Botrytis cinerea in the Lycopersicon esculentum fruit.

    PubMed

    Zheng, Yanyan; Hong, Hui; Chen, Lin; Li, Jingyuan; Sheng, Jiping; Shen, Lin

    2014-02-12

    Nitric oxide (NO) and mitogen-activated protein kinases (MAPKs) are signal molecules involved in the disease resistance of plants. To investigate the role of tomato MAPKs in the NO-mediated defense response, mature green tomatoes (Lycopersicon esculentum Mill. cv. Qian-xi) were treated with a MAPKs inhibitor (1,4-diamino-2,3-dicyano-1,4-bis(o-amino-phenylmercapto) butadiene (U0126)), NO donor sodium nitroprusside (SNP), and SNP plus U0126. Treatment with U0126 increased the incidence of disease and size of lesion areas in the tomato fruits after being inoculated with Botrytis cinerea. NO enhanced the resistance of the tomato fruits against Botrytis cinerea invasion and the activities of nitric oxide synthase, Chitinase, β-1,3-glucanase, polyphenol oxidase, and phenylalanine ammonia-lyase. However, the effects of NO on disease resistance were weakened by the MAPKs inhibitor. Meanwhile, the relative expression of LeMAPK1, LeMAPK2, and LeMAPK3 in the (SNP + U0126)-treated fruits was lower than that in the SNP-treated fruits. The results suggest that LeMAPK1/2/3 are involved in NO-induced disease resistance of tomato fruits against Botrytis cinerea.

  16. Overexpression of the tomato pollen receptor kinase LePRK1 rewires pollen tube growth to a blebbing mode.

    PubMed

    Gui, Cai-Ping; Dong, Xin; Liu, Hai-Kuan; Huang, Wei-Jie; Zhang, Dong; Wang, Shu-Jie; Barberini, María Laura; Gao, Xiao-Yan; Muschietti, Jorge; McCormick, Sheila; Tang, Wei-Hua

    2014-09-01

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane-localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP), a Rop guanine nucleotide exchange factor. Here, we show that pollen tubes overexpressing LePRK1 or a truncated LePRK1 lacking its extracellular domain (LePRK1ΔECD) have enlarged tips but also extend their leading edges by producing "blebs." Coexpression of LePRK1 and tomato PLIM2a, an actin bundling protein that interacts with KPP in a Ca(2+)-responsive manner, suppressed these LePRK1 overexpression phenotypes, whereas pollen tubes coexpressing KPP, LePRK1, and PLIM2a resumed the blebbing growth mode. We conclude that overexpression of LePRK1 or LePRK1ΔECD rewires pollen tube growth to a blebbing mode, through KPP- and PLIM2a-mediated bundling of actin filaments from tip plasma membranes. Arabidopsis thaliana pollen tubes expressing LePRK1ΔECD also grew by blebbing. Our results exposed a hidden capability of the pollen tube cell: upon overexpression of a single membrane-localized molecule, LePRK1 or LePRK1ΔECD, it can switch to an alternative mechanism for extension of the leading edge that is analogous to the blebbing growth mode reported for Dictyostelium and for Drosophila melanogaster stem cells. © 2014 American Society of Plant Biologists. All rights reserved.

  17. General parameter relations for the Shinnar-Le Roux pulse design algorithm.

    PubMed

    Lee, Kuan J

    2007-06-01

    The magnetization ripple amplitudes from a pulse designed by the Shinnar-Le Roux algorithm are a non-linear function of the Shinnar-Le Roux A and B polynomial ripples. In this paper, the method of Pauly et al. [J. Pauly, P. Le Roux, D. Nishimura, A. Macovski, Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm, IEEE Transactions on Medical Imaging 10 (1991) 56-65.] has been extended to derive more general parameter relations. These relations can be used for cases outside the five classes considered by Pauly et al., in particular excitation pulses for flip angles that are not small or 90 degrees. Use of the new relations, together with an iterative procedure to obtain polynomials with the specified ripples from the Parks-McClellan algorithm, are shown to give simulated slice profiles that have the desired ripple amplitudes.

  18. Modified versus classic alar base sutures after LeFort I osteotomy: a systematic review.

    PubMed

    Liu, Xianwen; Zhu, Songsong; Hu, Jing

    2014-01-01

    The purpose of this systematic review is to evaluate the efficacy of a new modified alar base cinch suture by comparing it with the commonly used classic alar base suture after LeFort I osteotomy. A comprehensive search strategy was performed to include interventional studies involving the comparisons of alar base suturing methods after LeFort I osteotomy. Data analyses were conducted using the random-effects model. Three studies with 146 participants undergoing LeFort I maxillary osteotomy were included in this review. The results showed that, compared with the classic method, both modified transseptal alar base suture and modified reinsertion sutures significantly decreased postoperative alar and alar base widening. The modified alar base cinch suture was more effective than the classic alar base suture in maintaining preoperative alar and alar base width after LeFort I osteotomy. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. 5. Former P&LE tracks (now CSXT) adjacent to trestle towards ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Former P&LE tracks (now CSXT) adjacent to trestle towards west. - Monongahela Connecting Railroad Company, Y Trestle, South side of Monongahela River between Thirty-fourth & Twenty-ninth Streets, Pittsburgh, Allegheny County, PA

  20. Landau and Lifshitz' formulation of Le Chatelier's principle: an insight into symbiosis?

    PubMed

    Halabi, T

    2013-12-01

    A correspondence allows application of Landau and Lifshitz' formulation of Le Chatelier's principle from statistical physics to a simple 2-D model of biological symbiosis. The insight: symbionts stabilize the occupation of narrow peaks on fitness landscape.

  1. A Multistep Equilibria-Redox-Complexation Demonstration to Illustrate Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Berger, Tomas G.; Mellon, Edward K.

    1996-01-01

    Describes a process that can be used to illustrate a number of chemical principles including Le Chatelier's principle, redox chemistry, equilibria versus steady state situations, and solubility of species. (JRH)

  2. An Overhead Demonstration of Some Descriptive Chemistry of the Halogens and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Hansen, Robert C.

    1988-01-01

    Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

  3. The Potassium-Argon Laser Experiment (KArLE): In Situ Geochronology for Planetary Missions

    NASA Astrophysics Data System (ADS)

    Cohen, B. A.

    2016-10-01

    KArLE is intended to yield in situ geochronology data and enhance functionality of existing flight instruments using flight hardware that would be reliable, reconfigurable and adaptable to multiple partner instruments and mission architectures.

  4. An Overhead Demonstration of Some Descriptive Chemistry of the Halogens and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Hansen, Robert C.

    1988-01-01

    Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

  5. 3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHEAST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  6. 10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 MANTEL (NOT ORIGINAL) SOUTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  7. 14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, SOUTHEAST BEDROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  8. 7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTH (FRONT) ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  9. 4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  10. Comparison of the severity of bilateral Le Fort injuries in isolated midface trauma.

    PubMed

    Bagheri, Shahrokh C; Holmgren, Eric; Kademani, Deepak; Hommer, Louis; Bell, R Bryan; Potter, Bryce E; Dierks, Eric J

    2005-08-01

    The Le Fort classification pattern established in 1901 by the French surgeon Rene Le Fort is commonly used in describing midface fractures. This frequently used classification system is based on predictable patterns of midface fractures initially described for blunt trauma. The purpose of this study was to compare the profile and outcome of patients with isolated bilateral Le Fort I, II, and III fractures. All patients presenting to the emergency department (ED) at Legacy Emanuel Hospital (Level I trauma center) in Portland, OR, between December 1990 and December 2003 with isolated bilateral Le Fort I, II, or III fractures with or without concomitant nonfacial injuries were identified retrospectively using the Hospital Trauma Registry. Patients were classified into study groups I (n = 22), II (n = 22), or III (n = 23) corresponding to the Le Fort classification, respectively. Sixty-seven patients had a diagnosis of isolated bilateral Le Fort I, II, or III fracture. The average Injury Severity Score (ISS) and hospital length of stay were 18.8 +/- 8.9 and 9.5 +/- 11.9 days, respectively. Blood alcohol was detected in 19 patients. Sixty-four injuries (95.5%) were secondary to blunt trauma, and the remaining 3 (4.5%), penetrating injuries. More than half of the patients (n = 35, 52.2%) were admitted to the intensive care unit (ICU), 18 patients (26.8%) were transferred to the hospital trauma ward from the ED, and 14 patients (20.9%) were taken directly to the operating room. Fifteen (22.4%) patients required a tracheostomy secondary to their maxillofacial injuries. A statistically significant difference in the ISS was detected between patients with Le Fort I versus those with II or III injuries ( P < .0001). Patients with Le Fort II or III fractures had a significantly higher probability of ICU admission or immediate operative intervention. Ten patients (43.5%) with Le Fort III injuries required tracheostomy versus 3 patients (13.6%) with Le Fort I, and 2 patients (9

  11. Le volvulus gastrique idiopathique aigu: à propos d'une nouvelle observation

    PubMed Central

    Abdelilah, Mouhsine; Jihad, Anzaoui; Rachid, Bouchentouf

    2013-01-01

    Le volvulus gastrique est une rotation anormale de l'estomac autour de son axe. La forme aiguë constitue une urgence chirurgicale. Le diagnostic est souvent retardé en raison d'une symptomatologie fréquemment non spécifique. Des signes respiratoires tels la dyspnée et le hoquet peuvent révéler cette pathologie. Les auteurs rapportent une nouvelle observation de volvulus gastrique aigu chez un adolescent de 17 ans, diagnostiqué par la tomodensitométrie, et confirmé par une intervention chirurgicale. Le traitement est chirurgical et consiste à détordre et fixer l'estomac pour prévenir la récidive. PMID:23503200

  12. Le schwannome malin du nerf grand sciatique chez l'enfant

    PubMed Central

    Lechqar, Maryem; Elbiache, Imad; Atarraf, Karima; Bouabdellah, Youssef; Afifi, My Abderahman

    2012-01-01

    Le schwannome malin est une tumeur très rare chez l'enfant (1 à 2% des tumeurs des tissus mous), elle se développe au dépend des cellules de schwanne. Dans ce travail, les auteurs rapportent un cas de schwannome malin développé au dépend du nerf grand sciatique. La radiographie de la cuisse de face et de profil était normale. L'imagerie par résonance magnétique a identifié une lésion le long du trajet du nerf grand sciatique. La tumeur a été réséquée en totalité emportant le nerf grand sciatique. L'examen anatomo-pathologique a confirmé le diagnostic. PMID:23133710

  13. Facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nguefack-Tsague, Georges; Kalla, Ginette Claude Mireille; Abessolo, Stéphanie Abo'o; Angwafo, Fru; Muna, Walinjom

    2014-01-01

    Introduction L'objectif de ce travail était de déterminer les facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala (Région du Sud) au Cameroun. Méthodes Il s'agissait d'une étude transversale, descriptive et analytique qui s'est déroulée de Février à Mai 2011. Pour cette étude, nous avons obtenu une clairance éthique. Résultats L’échantillon était constitué de 315 participants dont 181 (57,46%) hommes et 134 (42,54%) femmes. L’âge moyen était de 24,5±8ans (extrême: 15-45ans). Quarante personnes (40) étaient séropositifs, soit une prévalence de l'infection par le VIH de 12,7%. Cette prévalence augmentait significativement (p = 0) avec le nombre de partenaires occasionnels au cours des douze derniers mois, allant de 2,7% chez ceux n'ayant eu aucun partenaire occasionnel à 21,25% chez ceux ayant plus de trois partenaires occasionnels (RC = 9,72; IC = 1,27-74,14; P = 0,03). le fait d’être âgé entre 20 et 24 ans (RC = 4,88; IC = 1,74-13,67; p = 0), avoir plus de trois partenaires sexuels au cours des douze derniers mois (RC = 9,72; IC = 1,27-74,14; p = 0,03), avoir les rapports sexuels avec les prostitués (RC = 2,86; IC = 1,42-5,76; p = 0), avoir eu le chlamydia (RC = 3,00; IC = 1,07-8,39; p = 0,04), avoir eu la syphilis (RC = 3,35; IC = 1,57-7,14; p = 0), avoir des avantages sociaux lors du premier rapport sexuel (RC = 2,57; IC = 1,03-6,43; p = 0,04) constituaient des potentiels facteurs de risque du VIH. Conclusion Il apparait urgent d'intensifier les campagnes de sensibilisation au risque d'infection par le VIH et les maladies sexuellement transmissibles dans le district de santé de Meyomessala PMID:25419299

  14. Genome Sequence of Novosphingobium lindaniclasticum LE124T, Isolated from a Hexachlorocyclohexane Dumpsite

    PubMed Central

    Saxena, Anjali; Nayyar, Namita; Sangwan, Naseer; Kumari, Rashmi; Khurana, J. P.

    2013-01-01

    Novosphingobium lindaniclasticum LE124T is a hexachlorocyclohexane (HCH)-degrading bacterium isolated from a high-dosage-point HCH dumpsite (450 mg HCH/g soil) located in Lucknow, India (27°00′N and 81°09′E). Here, we present the annotated draft genome sequence of strain LE124T, which has an estimated size of 4.86 Mb and is comprised of 4,566 coding sequences. PMID:24029761

  15. LeČOns Sur Les Ondes De Gravité Des Fluides Incompressibles

    NASA Astrophysics Data System (ADS)

    van den Dungen, F. H.

    Le 3 Janvier 1814 au moment où les Alliés franchissant le Rhin allaient entamer la campagne de France, la classe des Sciences de l'Institut de France proposait comme sujet du grand prix de mathématique à décerner en Janvier 1816 la question suivante: "La théorie de la propagation des ondes à la surface d'un fluide pesant d'une profondeur infinie".

  16. Trends in Le Fort Fractures at a South American Trauma Care Center: Characteristics and Management.

    PubMed

    Oliveira-Campos, Gustavo Halak; Lauriti, Leandro; Yamamoto, Marcos Kazuo; Júnior, Rubens Camino; Luz, João Gualberto C

    2016-03-01

    To assess the trends in Le Fort (maxillary) fractures in patients seen at a South American trauma care center based on the characteristics and management of these. Of all patients with facial fractures seen at a trauma hospital during a six-year period, 50 (6.6 %) presented with Le Fort fractures. Medical charts were reviewed for characteristics presented and management performed. To improve the analyses, computed tomography and intraoperative findings were used. Statistical analyses involved descriptive statistics and the likelihood ratio test. The fractures were Le Fort II (52 %), Le Fort I (22 %), Le Fort type-associated (20 %) and Le Fort III (6 %). Male patients (90 %) in their third decade of life (38 %) were more frequent (p = 0.022). Traffic accidents (56 %) were the major etiologic factor (p = 0.048). There were 1.4 additional facial fractures per patient, with predominance of zygoma fractures (36.5 %). Most of the cases were managed by open reduction (60 %) (p = 0.015) with the subciliary approach (42.7 %) (p = 0.001). The 1.5-mm system was the most used fixation and the zygomaticomaxillary suture the most frequent location (p = 0.001). the most common patient with a Le Fort fracture is an adult male, with a Le Fort II fracture due to a traffic accident requiring surgical fixation on zygomaticomaxillary suture.

  17. Facteurs déterminants le regret après ligature tubaire

    PubMed Central

    Boufettal, Houssine; Mahdaoui, Sakher; Samouh, Naïma

    2014-01-01

    Introduction La ligature tubaire peut générer regret. Le but de cette étude est d’étudier le vécu après la stérilisation ainsi que le regret et ses facteurs de risque. Méthodes Il s'agit d'une étude rétrospective chez 52 femmes stérilisées entre 2004 et 2010. Résultats Vingt cinq (48%) femmes avaient regretté la réalisation de la ligature tubaire. La moyenne d’âge était de 40,5 ans. Le temps consacré aux explications était très court dans tous les cas. Trois quart des femmes n’était pas au courant des complications de la ligature tubaire. Le regret était dû au facteur religieux (23%), aux algies pelviennes (11,5%), au désir d'autres enfants (9,6%) ou à la prise de connaissance d'autres moyens contraceptifs (3,9%). Conclusion Un certains nombre de facteurs de risque de regret de la ligature tubaire sont retrouvés dans la littérature, comme dans notre série, dont l’âge, le désir de procréer, l'information incomplète, le délai de réflexion et le facteur religieux. PMID:25309644

  18. STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro

    USDA-ARS?s Scientific Manuscript database

    BACKGROUND: LePRK1 and LePRK2 are two pollen receptor kinases localized to the plasma membrane, where they are present in a high molecular weight complex (LePRK complex). LePRK2 is phosphorylated in mature and germinated pollen, but is dephosphorylated when pollen membranes are incubated with tomato...

  19. Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

    NASA Astrophysics Data System (ADS)

    Sendai, Shoichiro

    The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

  20. Le Châtelier reciprocal relations and the mechanical analog

    NASA Astrophysics Data System (ADS)

    Gilmore, Robert

    1983-08-01

    Le Châtelier's principle is discussed carefully in terms of two sets of simple thermodynamic examples. The principle is then formulated quantitatively for general thermodynamic systems. The formulation is in terms of a perturbation-response matrix, the Le Châtelier matrix [L]. Le Châtelier's principle is contained in the diagonal elements of this matrix, all of which exceed one. These matrix elements describe the response of a system to a perturbation of either its extensive or intensive variables. These response ratios are inverses of each other. The Le Châtelier matrix is symmetric, so that a new set of thermodynamic reciprocal relations is derived. This quantitative formulation is illustrated by a single simple example which includes the original examples and shows the reciprocities among them. The assumptions underlying this new quantitative formulation of Le Châtelier's principle are general and applicable to a wide variety of nonthermodynamic systems. Le Châtelier's principle is formulated quantitatively for mechanical systems in static equilibrium, and mechanical examples of this formulation are given.

  1. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

    PubMed Central

    Shen, Yue; Stracquadanio, Giovanni; Wang, Yun; Yang, Kun; Mitchell, Leslie A.; Xue, Yaxin; Cai, Yizhi; Chen, Tai; Dymond, Jessica S.; Kang, Kang; Gong, Jianhui; Zeng, Xiaofan; Zhang, Yongfen; Li, Yingrui; Feng, Qiang; Xu, Xun; Wang, Jun; Wang, Jian; Yang, Huanming; Boeke, Jef D.; Bader, Joel S.

    2016-01-01

    Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3′ UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes. PMID:26566658

  2. Rectified brownian transport in corrugated channels: Fractional brownian motion and Lévy flights.

    PubMed

    Ai, Bao-quan; Shao, Zhi-gang; Zhong, Wei-rong

    2012-11-07

    We study fractional brownian motion and Lévy flights in periodic corrugated channels without any external driving forces. From numerical simulations, we find that both fractional gaussian noise and Lévy-stable noise in asymmetric corrugated channels can break thermodynamical equilibrium and induce directed transport. The rectified mechanisms for fractional brownian motion and Lévy flights are different. The former is caused by non-uniform spectral distribution (low or high frequencies) of fractional gaussian noise, while the latter is due to the nonthermal character (occasional long jumps) of the Lévy-stable noise. For fractional brownian motion, average velocity increases with the Hurst exponent for the persistent case, while for the antipersistent case there exists an optimal value of Hurst exponent at which average velocity takes its maximal value. For Lévy flights, the group velocity decreases monotonically as the Lévy index increases. In addition, for both cases, the optimized periodicity and radius at the bottleneck can facilitate the directed transport. Our results could be implemented in constrained structures with narrow channels and pores where the particles undergo anomalous diffusion.

  3. Intrication de deux atomes en utilisant le blocage de Rydberg

    NASA Astrophysics Data System (ADS)

    Gaëtan, A.

    2010-12-01

    Considérons un système quantique constitué de deux sous-systèmes : on dit qu'il est dans un état intriqué s'il existe des corrélations quantiques entre les états de ces derniers. La compréhension et la mise en œuvre d'états intriqués ont de nombreuses applications (métrologie quantique, étude des systèmes fortement corrélés, traitement quantique de l'information, etc.) et constituent le contexte général de ce travail de thèse. Plus en détail, nous démontrons la réalisation d'un état intriqué de deux atomes neutres piégés indépendamment. Pour cela, nous exploitons le phénomène de blocage de Rydberg : lorsqu'on essaie d'exciter simultanément deux atomes séparés de quelques micromètres vers un état de Rydberg donné, la forte interaction entre atomes de Rydberg peut empêcher cette excitation simultanée. Dans ce cas, seul un des deux atomes est excité et l'on génère ainsi des corrélations quantiques entre les états des deux atomes, c'est-à-dire de l'intrication. Dans notre expérience, deux atomes de 87Rb dans l'état fondamental 5S1/2 sont piégés chacun dans une pince optique microscopique, à une distance relative de 4 micromètres. En réalisant des transitions entre l'état 5S1/2 et l'état de Rydberg 58D3/2 par des transitions à deux photons, nous obtenons un état intriqué des deux atomes dans les sous-niveaux |5S1/2, f = 1, mf = 1> et |5S1/2, f = 2, mf = 2>. Afin de quantifier l'intrication, nous mesurons la fidélité par rapport à l'état-cible en réalisant des transitions Raman entre ces deux sous-niveaux. La fidélité des paires d'atomes présentes à la fin de l'expérience est supérieure à la valeur seuil de 0,5, ce qui prouve la création d'un état intriqué.

  4. Lymphome et grossesse: le point de vue de l'obstétricien, à propos de 2 cas

    PubMed Central

    Amourak, Sarah; Alaoui, Fatimazahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    L'association lymphome et grossesse est une situation rare, mais non exceptionnelle, relevant de la coïncidence. Le lymphome vient en 4ème position des cancers rencontrés chez la femme enceinte, La clinique est trompeuse et inconstante, le diagnostic reste histologique et on distingue 2 types: lymphome malin hodgkinien (LMH) et le lymphome malin non hodgkinien (LMNH). Malgré le contexte de véritable urgence hématologique, la décision d'initier ou de différer le traitement est délicate, influencée par le type de lymphome, son extension et sa localisation, la répercussion organique, le degré de maturation f'tale, les risques obstétricaux et les valeurs éthiques, culturelles et religieuses de la patiente. Le traitement consiste essentiellement à une chimiothérapie. Le LH durant la grossesse est relativement moins agressif et d’évolution plus favorable que le LMNH. PMID:25883744

  5. SusG: A Unique Cell-Membrane-Associated [alpha]-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules

    SciTech Connect

    Koropatkin, Nicole M.; Smith, Thomas J.

    2010-09-21

    SusG is an {alpha}-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structure of SusG has an unusual extended, bilobed structure composed of amylase at one end and an unprecedented internal carbohydrate-binding motif at the other. Structural studies further demonstrate that the carbohydrate-binding motif binds maltooligosaccharide distal to, and on the opposite side of, the amylase catalytic site. SusG has an additional starch-binding site on the amylase domain immediately adjacent to the active cleft. Mutagenesis analysis demonstrates that these two additional starch-binding sites appear to play a role in catabolism of insoluble starch. However, elimination of these sites has only a limited effect, suggesting that they may have a more important role in product exchange with other Sus components.

  6. SusG: a unique cell-membrane-associated alpha-amylase from a prominent human gut symbiont targets complex starch molecules.

    PubMed

    Koropatkin, Nicole M; Smith, Thomas J

    2010-02-10

    SusG is an alpha-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structure of SusG has an unusual extended, bilobed structure composed of amylase at one end and an unprecedented internal carbohydrate-binding motif at the other. Structural studies further demonstrate that the carbohydrate-binding motif binds maltooligosaccharide distal to, and on the opposite side of, the amylase catalytic site. SusG has an additional starch-binding site on the amylase domain immediately adjacent to the active cleft. Mutagenesis analysis demonstrates that these two additional starch-binding sites appear to play a role in catabolism of insoluble starch. However, elimination of these sites has only a limited effect, suggesting that they may have a more important role in product exchange with other Sus components.

  7. Évolution des lignes directrices sur le traitement de la dyslipidémie

    PubMed Central

    John Bosomworth, N.

    2014-01-01

    Résumé Objectif Comprendre comment les nouvelles lignes directrices sur la prise en charge du risque cardiovasculaire publiées par l’American Heart Association et l’American College of Cardiology (AHA-ACC) peuvent être interprétées et utilisées dans le contexte canadien. Sources des données Les lignes directrices de l’AHA-ACC ont été examinées, de même que toutes les références. Des recherches indépendantes dans PubMed ont été effectuées pour inclure l’ajout aux statines d’autres antihyperlipidémiants et l’emploi de calculatrices médicales visant à aider le patient à comprendre. Message principal Les nouvelles lignes directrices de l’AHA-ACC s’appuient sur les meilleures données probantes disponibles actuellement en matière de traitement de la dyslipidémie. Cela inclut le risque cardiovasculaire (CV) sur 10 ans comme seuil thérapeutique au lieu du taux de cholestérol des lipoprotéines de faible densité, de même que l’abandon des cibles thérapeutiques de lipoprotéines de faible densité. On met de plus en plus l’accent sur les interventions alimentaires et l’exercice, avec l’amorce d’un effort pour quantifier l’effet de ces interventions. Les statines constituent la principale intervention pharmacologique, et l’ajout d’autres médicaments pour accentuer la baisse lipidique n’est plus recommandé. En ce qui concerne l’application au Canada, les tables de risque de Framingham sont plus appropriées pour évaluer le risque que les équations de cohortes regroupées utilisées aux États-Unis. Les calculatrices du risque de maladie cardiovasculaire (MCV) devraient contenir de l’information sur l’âge cardiovasculaire et devraient pouvoir illustrer le risque et les interventions de rechange afin d’aider le patient à comprendre et de favoriser la prise de décision éclairée. Conclusion L’attention sur les meilleures données probantes concernant le risque CV peut simplifier le traitement de la

  8. New Middle Miocene Bryozoa from Gârbova de Sus (Romania) and their relationship to the sedimentary environment

    NASA Astrophysics Data System (ADS)

    Zágoršek, Kamil; Filipescu, Sorin; Holcová, Katarína

    2010-12-01

    The section of Gârbova de Sus contains diverse fossil groups and rich bryozoan assemblages, with 77 species altogether. Several taxa have been recognized as very important in the assemblage and two new taxa are described in detail: Poricella garbovensis sp. nov. and Therenia transylvanica sp. nov. Foraminifera and calcareous nannofossil assemblages were used for biostratigraphic and paleoenvironmental interpretations. On the basis of sedimentological features and micropaleontological data, the sequence of paleoenvironments can be subdivided into two intervals indicating slightly different climatic conditions.

  9. High Prevalence of Co-Infection with Multiple Torque Teno Sus Virus Species in Italian Pig Herds

    PubMed Central

    Blois, Sylvain; Mallus, Francesca; Liciardi, Manuele; Pilo, Cristian; Camboni, Tania; Macera, Lisa; Maggi, Fabrizio; Manzin, Aldo

    2014-01-01

    Torque teno viruses (TTVs) are a large group of vertebrate-infecting small viruses with circular single-stranded DNA, classified in the Anelloviridae family. In swine, two genetically distinct species, Torque teno sus virus 1a (TTSuV1a) and 1b (TTSuV1b) are currently grouped into the genus Iotatorquevirus. More recently, a novel Torque teno sus virus species, named Torque teno sus virus k2b (TTSuVk2b), has been included with Torque teno sus virus k2a (TTSuVk2a) into the genus Kappatorquevirus. In the present study, TTSuV1 (TTSuV1a and TTSuV1b), TTSuVk2a and TTSuVk2b prevalence was evaluated in 721 serum samples of healthy pigs from Sardinian farms, insular Italy. This is the largest study to date on the presence of TTSuV in healthy pigs in Italy. The global prevalence of infection was 83.2% (600/721), being 62.3% (449/721), 60.6% (437/721), and 11.5% (83/721) the prevalence of TTSuV1, TTSuVk2a and TTSuVk2b, respectively. The rate of co-infection with two and/or three species was also calculated, and data show that co-infections were significantly more frequent than infections with single species, and that TTSuV1+TTSuVk2a double infection was the prevalent combination (35.4%). Quantitative results obtained using species-specific real time-qPCR evidenced the highest mean levels of viremia in the TTSuV1 subgroup, and the lowest in the TTSuVk2b subgroup. Interestingly, multiple infections with distinct TTSuV species seemed to significantly affect the DNA load and specifically, data highlighted that double infection with TTSuVk2a increased the viral titers of TTSuV1, likewise the co-infection with TTSuVk2b increased the titers of TTSuVk2a. PMID:25411972

  10. La plastie en rail dans le traitement des brides rétractiles du creux poplite

    PubMed Central

    Achbouk, A.; Khales, A.; Bourra, K.; Tourabi, K.; Ababou, K.; Ihrai, H.

    2011-01-01

    Summary Les Auteurs décrivent le cas d’un patient âgé de 45 ans atteint de brûlures thermiques par flammes suite à la déflagration d’une bonbonne de gaz. Les lésions initiales intéressaient les quatre membres (en particulier, le genou) et le tronc. La prise en charge initiale a consisté en une excision-greffe précoce des membres. L’évolution a été marquée par la survenue de cicatrices hypertrophiques au niveau des zones non greffées et à la bordure de la greffe ainsi que la survenue de brides rétractiles. Devant l’handicap fonctionnel engendré par la bride à cause de la limitation importante de l’extension, le patient a été admis pour cure chirurgicale. Grâce à la technique en rail décrite, le patient a pu récupérer une fonction normale du genou. Les suites ont été simples avec une durée d’hospitalisation d’un mois. Le résultat esthétique est relativement satisfaisant. La technique en rail est un moyen parmi l’arsenal thérapeutique qui permet de traiter la bride du creux poplité. Sa simplicité, sa facilité technique et son résultat satisfaisant ainsi que ses suites simples permettent de la rendre une technique très prisée dans le traitement de ce type de bride. PMID:21991240

  11. Sur la reponse en frequence du tissu nerveux dans le cortex

    NASA Astrophysics Data System (ADS)

    Bedard, Claude

    Dans cette These de Physique, nous avons etudie la dependance en frequence du champ electrique du tissu nerveux dans le cortex. Ce champ est aussi designe par "Local field Potential" LFP dans la litterature scientifique. Cette etude est fondee sur la theorie du champ electromagnetisme de Maxwell et sur de l'information tiree de la donne experimentale. Le resultat essentiel de cette These est que la grandeur enorme du temps de relaxation de Maxwell des membranes cellulaires semble etre la cause principale de la dependance en frequence des LFPs. Cette dependance en frequence causee par chaque membrane cellulaire est l'analogue d'un circuit RC ou la resistance R est la resistivite parallele d'une membrane cellulaire, et ou la capacite C est la permittivite electrique de la membrane. L'effet resultant d'un tres grand nombre de cellules donne un spectre de Fourier dont l'enveloppe est tres pres d'un signal en 1/f. Le modele physique propose dans cette These permet de lier les mesures prises a l'interieur d'une dendrite des variations de potentiel electrique a celles prises dans le liquide extracellulaire. De plus, cette These semble ouvrir la possibilite de mesurer le temps de relaxation de Maxwell des membranes cellulaires a l'aide de la mesure de la reponse en frequence du potentiel electrique extracellulaire (LFP). Enfin, cette These permet de lever le voile sur un sujet peu etudie, principalement en raison de la difficulte que represente l'etude des phenomenes electriques dans des milieux complexes comme les tissus vivants. En particulier, le probleme du filtrage frequentiel du potentiel electrique extracellulaire est une propriete fondamentale du tissu nerveux et son origine n'est pas connue.

  12. LeNRT2.3 functions in nitrate acquisition and long-distance transport in tomato.

    PubMed

    Fu, Yanlei; Yi, Hongying; Bao, Juan; Gong, Jiming

    2015-04-28

    Nitrogen plays an important role in plant growth and development. Nitrate transporters have been extensively studied in Arabidopsis, but in tomato they have not been functionally characterized. In this study, we report the functions of LeNRT2.3 in nitrate transport in tomato. Our results show that LeNRT2.3 is induced by nitrate, and mainly localizes to the plasma membranes of rhizodermal and pericycle cells in roots. Further analysis in Xenopus oocytes showed that LeNRT2.3 mediates low-affinity nitrate transport. 35S:LeNRT2.3 increased nitrate uptake in root and transport from root to shoot. More interestingly, 35S:LeNRT2.3 showed high biomass and fruit weight. Taken together, these results suggest that LeNRT2.3 plays a double role in nitrate uptake and long-distance transport in tomato.

  13. Effets du stress familial lié au diabète sur le contrôle glycémique chez les jeunes diabétiques de type 1

    PubMed Central

    Tsiouli, Elina; Alexopoulos, Evangelos C.; Stefanaki, Charikleia; Darviri, Christina; Chrousos, George P.

    2013-01-01

    Objectif Examiner la façon dont le stress familial influence le contrôle glycémique chez les patients diabétiques de moins de 18 ans. Sources des données Une recherche des études pertinentes publiées depuis 1990 a été réalisée dans PubMed et Scopus à l'aide des mots-clés suivants en anglais: diabetes type 1, glycemic control, family stress, family conflict et family function. Sélection des études La recension initiale a permis de cerner un total de 1 478 articles. La synthèse finale portrait sur 6 études de cohortes, 3 études transversales et 1 étude qualitative dans lesquelles le stress familial était évalué à l'aide d'instruments de mesure des conflits spécifiquement reliés au diabète et le contrôle glycémique était mesuré en fonction de l'hémoglobine glycosylée. Synthèse Dans la plupart des études, il existait une corrélation négative entre le stress familial et le contrôle glycémique des patients. Le bon fonctionnement familial était fortement relié à un bon contrôle glycémique des patients, tandis que les conflits familiaux étaient associés à un mauvais contrôle glycémique. Les familles dont la situation socioéconomique était défavorisée, celles ayant des adolescents atteints de diabète et les familles monoparentales étaient plus enclines à vivre un stress relié au diabète et étaient, par conséquent, plus susceptibles de connaître un moins bon contrôle glycémique. Conclusion Les interventions psychologiques thérapeutiques et les programmes éducatifs peuvent aider à atténuer le stress familial relié au diabète et amélioreront probablement le contrôle glycémique.

  14. THE CHALLENGE OF DETECTING CLASSICAL SWINE FEVER VIRUS CIRCULATION IN WILD BOAR (SUS SCROFA): SIMULATION OF SAMPLING OPTIONS.

    PubMed

    Sonnenburg, Jana; Schulz, Katja; Blome, Sandra; Staubach, Christoph

    2016-10-01

    Classical swine fever (CSF) is one of the most important viral diseases of domestic pigs ( Sus scrofa domesticus) and wild boar ( Sus scrofa ). For at least 4 decades, several European Union member states were confronted with outbreaks among wild boar and, as it had been shown that infected wild boar populations can be a major cause of primary outbreaks in domestic pigs, strict control measures for both species were implemented. To guarantee early detection and to demonstrate freedom from disease, intensive surveillance is carried out based on a hunting bag sample. In this context, virologic investigations play a major role in the early detection of new introductions and in regions immunized with a conventional vaccine. The required financial resources and personnel for reliable testing are often large, and sufficient sample sizes to detect low virus prevalences are difficult to obtain. We conducted a simulation to model the possible impact of changes in sample size and sampling intervals on the probability of CSF virus detection based on a study area of 65 German hunting grounds. A 5-yr period with 4,652 virologic investigations was considered. Results suggest that low prevalences could not be detected with a justifiable effort. The simulation of increased sample sizes per sampling interval showed only a slightly better performance but would be unrealistic in practice, especially outside the main hunting season. Further studies on other approaches such as targeted or risk-based sampling for virus detection in connection with (marker) antibody surveillance are needed.

  15. A cephalometric comparative study of class II correction with Sabbagh Universal Spring (SUS2) and Forsus FRD appliances

    PubMed Central

    Oztoprak, Mehmet Oguz; Nalbantgil, Didem; Uyanlar, Ayhan; Arun, Tulin

    2012-01-01

    Objective The purpose of this clinical prospective study was to compare the dentofacial changes produced by the Sabbagh Universal Spring (SUS2) and Forsus FRD appliances in late adolescent patients with Class II malocclusion, and quantify them in comparison with an untreated group. Method: The study was carried out on 59 patients with skeletal and dental Class II malocclusion due to retrognatic mandible. Among these, 20 were treated with SUS2, 20 were treated with FRD, and no treatment was done to 19 subjects as the control group. 36 cephalometric landmarks were identified on each lateral cephalometric radiograph. Results: The effects of both appliances were dentoalveolar and no significant vertical and sagittal skeletal effect on maxilla and mandible was achieved. The retrusion and extrusion of the maxillary incisors as well as the protrusion and intrusion of mandibular incisors were found to be statistically significant in both treatment groups. Soft tissue profile improvement was limited in both treatment groups. Conclusions: Both appliances corrected Class II discrepancies through dentoalveolar changes; however lower incisor proclination was more prominent with the Forsus FRD. PMID:22904659

  16. [Identification and characterization of constituent elements of an intervention: pre-evaluation of the "ParticipaSUS" policy].

    PubMed

    Bezerra, Luciana Caroline de Albuquerque; Alves, Cinthia Kalyne de Almeida; Reis, Yluska Almeida Coelho Dos; Samico, Isabella; Felisberto, Eronildo; Carvalho, André Luis Bonifácio de; Silva, Greciane Soares da

    2012-04-01

    This article presents the results of a pre-evaluation of the National Policy of Strategic and Participative Management of the Unified Health System (ParticipaSUS). It involved a feasibility study conducted between October 2010 and March 2011 with Federal Management and the Strategic and Participative Management Department/Ministry of Health as the unit of analysis. Document analysis was performed and consensus meetings were held with professionals of the SSPM/MH and academic area. A logical model and analysis and judgment matrix with criteria, indicators, standards, data sources and cut-off points was prepared. A description of the intervention elicited discussion on concepts, principles, guidelines and actions. The consensus was that the principles and guidelines prioritized the 'Support to Participative Management' component. The focal point for elaboration of the logical model was action at federal level on each component, as official documents failed to list them. The ParticipaSUS policy is an intervention open to evaluation, albeit its plausibility has been established. The pre-evaluation proved to be appropriate and better understood by professionals, with clearer definition of objectives and goals, while duly highlighting priority areas for future evaluation.

  17. Analysis of 6-pyruvyl tetrahydropterin synthase, a target gene product of su(s) suppressor in Drosophila

    SciTech Connect

    Yim, J.J.; Park, Y.S.; Kim, J.H.; Jacobson, K.B. . Dept. of Microbiology; Oak Ridge National Lab., TN )

    1989-01-01

    Of the 20 suppressor mutants listed in Drosophila, su(s){sup 2} has been studied for the biochemical characterization of the suppression. In su(s){sup 2} suppression, some mutants at vermilion (v, 1-33.0), sable (s, 1-43.0), speck (sp, 2-107.0), and purple (pr, 2-54.5) are suppressible by mutants at the suppressor of sable (su(s)) locus. There have been many reports of suppression mechanism studies in purple led to purple loci. The biochemical studies in purple led to in vitro demonstration of a su(s){sup +} gene product as a negative effector against suppressed purple PPH{sub 4} synthase, which has been also demonstrated in the gene product of vermilion more recently. Both studies led to a proposal for a posttranslational mechanism in which the su(s){sup +} gene produces a substance that interferes with the function of the target enzymes from the purple and vermilion mutant. In contrast to the transcriptional regulation of the su(s) locus the posttranslational mechanism is based on qualitative differences between wild and suppressed enzyme. Therefore this investigation was to determine if any quantitative or qualitative differences exist between the mutant and wild type target enzymes. 7 refs., 4 figs.

  18. Al2O3/SUS304 Brazing via AgCuTi-W Composite as Active Filler

    NASA Astrophysics Data System (ADS)

    Su, Cherng-Yuh; Zhuang, Xie-Zongyang; Pan, Cheng-Tang

    2014-03-01

    Alumina ceramic (α-Al2O3) was brazed to stainless steel (SUS304) using an Ag-Cu-Ti + W composite filler and a traditional active brazing filler alloy (CuSil-ABA). Then, the effects of the presence of W particles and of the brazing parameters on the microstructures and mechanical properties of the brazed joints were investigated. The maximum tensile strength of the joints obtained using Ag-Cu-Ti + W composite filler was 13.2 MPa, which is similar to that obtained using CuSil-ABA filler (13.5 MPa). When the joint was brazed at 930 °C for 30 min, the tensile strengths decreased for both kinds of fillers, although the strength was slightly higher for the Ag-Cu-Ti + W composite filler than for the Ag-Cu-Ti filler. The interfacial microstructure results show that the Ti reacts with W to form a Ti-W-O compound in the brazing alloy. When there are more W particles in the brazing alloy, the thickness of the Ti X O Y reaction layer near the alumina ceramic decreases. Moreover, W particles added to the brazing alloy can reduce the coefficient of thermal expansion of the brazing alloy, which results in lower residual stress between the Al2O3 and SUS304 in the brazing joints and thus yields higher tensile strengths as compared to those obtained using the CuSil-ABA brazing alloy.

  19. [Research program for the Brazilian Unified Health System (SUS): the contribution to health management and services in Paraiba State, Brazil].

    PubMed

    Celino, Suely Deysny de Matos; Costa, Gabriela Maria Cavalcanti; França, Inácia Sátiro Xavier de; Araújo, Ednaldo Cavalcante de

    2013-01-01

    The shared management in health of the Research Program for the Unified Health System (PPSUS) has the purpose of funding research in priority areas for the health of the Brazilian population. The scope of this qualitative study is to understand the researchers' perception of the contribution of research funded by the PPSUS invitations to bid in the State of Paraiba, for resolving the priority health problems of the Paraiba population, for reducing regional inequalities in health and for bolstering the management of SUS. A documentary survey of the bids and final reports of research and a semi-structured interview with 28 coordinators of these studies was conducted. Triangulation strategy of data was used and subsequently subjected to content analysis, which converged with the categories: solving the health problems; reducing regional inequalities; contribution to management. Paraiba state needs adjustments such that the PPSUS can be fully implemented, ensuring that the knowledge generated can be converted into health policies and actions, since the research funded respond to the health needs of the population and difficulties in SUS management.

  20. Prescription of psychoactive drugs in patients attended by the SUS at Manhuaçu - MG (Brazil)

    PubMed Central

    Gonçalves, Daniel P.; Silva, Ian V.; Rangel, Letícia B.; Rezende, Lucas C.

    Objective In this study we present the development of a database of psychoactive drugs dispensed to patients attended by the Brazilian Public Health System (SUS) in the city of Manhuaçu, Minas Gerais and the pattern of drug prescription in this city. Methods 827 patients under psychoactive treatment and attended by SUS were surveyed and information such as gender, degree of education, age, marital status were collected. The collected data were analyzed in order to outline patients' profile and the dispensing and information was used to the access the pattern of psychoactive drug use in the city. Results Women accounted for 67.2% of the population and age seemed to influence positively the use of psychoactive drugs. Benzodiazepines and antidepressants were among the most prescribed drugs especially after 20 years of age, while in the younger population the antipsychotics and antiepileptics were the mainly prescribed drugs. Antiepileptics/mood stabilizers seemed to be prescribed mainly to single men and women. Conclusions Personal data concerning gender, age and marital status are related with psychoactive drug dispensing. The collected data will serve as a support for the performance of pharmacists responsible for dispensing psychoactive drugs in the municipality. PMID:24198857

  1. Pertinence de l'implantation de la filiere granule de bois pour le Quebec

    NASA Astrophysics Data System (ADS)

    Tremblay, Stephan

    Les spécialistes avancent que le marché mondial de l'énergie en forte demande et en offre limitée nécessitera bientôt toutes les formes d'énergie disponibles. Le granulé de bois est une forme de bioénergie principalement utilisée pour le chauffage des bâtiments et pourrait être davantage considéré dans l'offre énergétique du Québec. Comme le Québec est un territoire où il fait froid et donc susceptible de pouvoir se tourner vers cette forme d'énergie, l'objectif de ce mémoire est d'en analyser les avantages. Pour ce faire, nous commencerons par démontrer la croissance des besoins énergétiques sur les plans national et international et dresser un portrait des différentes formes d'énergies consommées au Québec. Puisque la majorité des Québécois chauffent leurs bâtiments à l'hydroélectricité, nous analyserons à travers le plan d'approvisionnement d'Hydro-Québec le portrait de la production et de la consommation de cette forme d'énergie renouvelable. Cela nous permettra de constater le défi face à la gestion de surplus importants, sauf pendant la période hivernale, et ce faisant, l'obligation de la société d'État d'utiliser davantage ses centrales au gaz ou de se tourner vers l'importation de l'électricité. Dans la même lignée, un regard sera porté sur les perspectives d'utilisation de l'hydroélectricité sur les plans de la production d'aluminium, de l'exportation et de l'utilisation dans l'électrification des transports au Québec. Cette analyse se fera dans l'objectif de s'interroger sur la pertinence d'utiliser cette source d'énergie dans le chauffage plutôt que dans des secteurs plus créateurs de richesse. Nous poserons ensuite l'hypothèse que le granulé de bois pourrait être un bon substitut à une autre forme d'énergie utilisée dans le chauffage, soit le mazout. Avant de dresser un portrait de ce combustible fossile, nous ferons celui de la production et de la consommation de granulés sur les plans r

  2. Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence

    PubMed Central

    Moore, Ainsley; Patterson, Christopher; Lee, Linda; Vedel, Isabelle; Bergman, Howard

    2014-01-01

    Résumé Objectif Revoir les stratégies diagnostiques de la maladie d’Alzheimer, actualiser les recommandations concernant le traitement des symptômes de démence et proposer une approche thérapeutique à la démence d’apparition précoce et d’évolution rapide. Composition du comité Des spécialistes et des délégués de diverses régions du Canada et représentant diverses disciplines pertinentes ont discuté et se sont mis d’accord sur les révisions à apporter aux lignes directrices de 2006. Méthodologie On a eu recours au système GRADE (grading of recommendations, assessment, development, and evaluation) pour évaluer le consensus concernant les recommandations, lequel était défini comme suit : lorsque 80 % ou plus des participants ont voté en faveur de la recommandation. La cote des données probantes est rapportée lorsque cela est possible. Rapport important pour les médecins de famille, malgré les progrès effectués dans les domaines des biomarqueurs liquidiens et de la neuro-imagerie, le diagnostic de démence au Canada demeure fondamentalement clinique. De nouveaux critères cliniques essentiels de diagnostic de la maladie d’Alzheimer en reconnaissent dorénavant les formes moins fréquentes et non amnestiques. La démence précoce, une affection rare, mais importante, devrait inciter les médecins à aiguiller les patients vers un spécialiste ayant accès à des conseillers en génétique. La démence d’évolution rapide, mal définie dans la littérature, faciliterait le dépistage de cette affection rare, mais importante. Les inhibiteurs de la cholinestérase sont maintenant indiqués pour le traitement d’affections autres que la maladie d’Alzheimer. Des lignes directrices concernant l’arrêt du traitement, lesquelles n’existaient pas auparavant, sont également apparues. De nouvelles données probantes sur le recours à la mémantine, aux antidépresseurs et à d’autres agents psychotropes dans le traitement de la

  3. Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

    NASA Astrophysics Data System (ADS)

    Bourdi, Taoufik

    Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents

  4. The Le Fort III osteotomy: to distract or not to distract?

    PubMed

    Fearon, J A

    2001-04-15

    Treatment of the craniofacial dysostoses (e.g., Crouzon, Apert, Pfeiffer, Saethre-Chotzen syndromes) is critically dependent on the successful advancement of the midface with a Le Fort III procedure. The purpose of this retrospective clinical outcome study was to evaluate a new technique for distracting the Le Fort III procedure and to compare its results in growing children with those of the standard Le Fort III osteotomy. The records of 22 children were reviewed; 10 patients (mean age, 6.5 years) underwent a standard Le Fort III procedure, and 12 patients (mean age, 7.5 years) underwent a Le Fort III distraction procedure. The distraction group included two separate techniques, bilateral buried distraction (n = 2) and halo distraction (n = 10). Preoperative and 2- to 3-month postoperative cephalograms were analyzed. The average horizontal advancement achieved in the standard Le Fort III group was 6 mm, compared with 19 mm of advancement in the distraction group (p Le Fort III group. However, in the distraction group two patients experienced normalization of sleep studies postoperatively as measured by respiratory disturbance index, and two patients underwent successful decannulation of tracheotomies. For aesthetic reasons, halo distraction was preferred over bilateral buried distraction. With halo distraction the vector of traction is focused in the facial midline, which helps to reposition the concave midface and to provide a more convex facial profile. In growing children, the ideal vector for distraction is determined by the malar position and not by dental occlusion. The amount of overcorrection can be calculated from tables of normal anthropologic data. On this preliminary review, it was concluded that the use of

  5. Le modele de Hubbard bidimensionnel a faible couplage: Thermodynamique et phenomenes critiques

    NASA Astrophysics Data System (ADS)

    Roy, Sebastien

    Une etude systematique du modele de Hubbard en deux dimensions a faible couplage a l'aide de la theorie Auto-Coherente a Deux Particules (ACDP) dans le diagramme temperature-dopage-interaction-sauts permet de mettre en evidence l'influence des fluctuations magnetiques sur les proprietes thermodynamiques du systeme electronique sur reseau. Le regime classique renormalise a temperature finie pres du dopage nul est marque par la grandeur de la longueur de correlation de spin comparee a la longueur thermique de de Broglie et est caracterisee par un accroissement drastique de la longueur de correlation de spin. Cette croissance exponentielle a dopage nul marque la presence d'un pic de chaleur specifique en fonction de la temperature a basse temperature. Une temperature de crossover est alors associee a la temperature a laquelle la longueur de correlation de spin est egale a la longueur thermique de de Broglie. C'est a cette temperature caracteristique, ou est observee l'ouverture du pseudogap dans le poids spectral, que se situe le maximum du pic de chaleur specifique. La presence de ce pic a des consequences sur l'evolution du potentiel chimique avec le dopage lorsque l'uniformite thermodynamique est respectee. Les contraintes imposees par les lois de la thermodynamique font en sorte que l'evolution du potentiel chimique avec le dopage est non triviale. On demontre entre autres que le potentiel chimique est proportionnel a la double occupation qui est reliee au moment local. Par ailleurs, une derivation de la fonction de mise a l'echelle de la susceptibilite de spin a frequence nulle au voisinage d'un point critique marque sans equivoque la presence d'un point critique quantique en dopage pour une valeur donnee de l'interaction. Ce point critique, associe a une transition de phase magnetique en fonction du dopage a temperature nulle, induit un comportement non trivial sur les proprietes physiques du systeme a temperature finie. L'approche quantitative ACDP permet de

  6. Cost-effectiveness analysis of paricalcitol versus calcitriol for the treatment of SHPT in dialytic patients from the SUS perspective.

    PubMed

    Menezes, Fabiana Gatti de; Abreu, Rodrigo Martins; Itria, Alexander

    2016-01-01

    Secondary hyperparathyroidism (SHPT) is a consequence of chronic kidney disease. The treatment at the Brazilian Unified Heath System (SUS) is performed with calcitriol, a drug which favors hypercalcemia and/or hyperphosphatemia, hindering the control of SHPT. Another option is paricalcitol, which causes parathormone (PTH) suppression faster than calcitriol, with minor changes in calcium-phosphorus product and calcium and phosphorus serum levels. This study aims to develop a cost-effectiveness analysis of paricalcitol versus calcitriol for patients in dialytic treatment with SHPT, from the SUS perspective. A Markov decision model was developed for patients ≥ 50 years old with end stage renal disease in dialytic treatment and SHPT. Quarterly cycles and a lifetime time horizon were considered. Life years (LY) gained were assessed as clinical outcome. Clinical and economic inputs were obtained from systematic literature review and official databases. Costs are presented in Brazilian real (BRL), for the year 2014. In the base case: paricalcitol generated a clinical benefit of 16.28 LY gained versus 14.11 LY gained with calcitriol, total costs of BRL 131,064 and BRL 114,262, respectively, determining an incremental cost-effectiveness ratio of BRL 7,740 per LY gained. The data robustness was confirmed by the sensitivity analysis. According to cost-effectiveness threshold recommended by the World Health Organization for 2013, the treatment of SHPT in patients on dialysis with paricalcitol is cost-effective when compared to calcitriol, from the public healthcare system perspective, in Brazil. O hiperparatireoidismo secundário (HPTS) é uma consequência da doença renal crônica. O tratamento no SUS é realizado com calcitriol, que favorece a hipercalcemia e/ou hiperfosfatemia, dificultando o controle do HPTS. Uma opção clinicamente relevante é o paricalcitol, que ocasiona a supressão do paratormônio (PTH) de forma mais rápida que o calcitriol e com menores altera

  7. Amphibians and Reptiles of the state of Nuevo León, Mexico.

    PubMed

    Lemos-Espinal, Julio A; Smith, Geoffrey R; Cruz, Alexander

    2016-01-01

    We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed.

  8. [Nicolás León, pioneer figure in the history of medicine].

    PubMed

    Rodríguez, Martha Eugenia

    2003-01-01

    To study Nicolás León (1859-1929) as historian of medicine, field in which he left 48 publications, out of a total of approximately 525. Most of the information analyzed is supported by primary sources, written by León himself. Nicolás León contributed mainly to present a general outlook of the history of medicine in Mexico, obstetrics being the field which he most thoroughly investigated, from Prehispanic period up to León's own times. The fact that he faced problems in order to obtain information, made him not only write, but also compile scattered data and uncommon or peculiar works. Nicolás León can be considered as one of the pioneers in the history of medicine, field which he enthusiastically encouraged, first from the city where he was born in the State of Michoacán, and later on, in Mexico City. In fact, we may assure that he was much more important as a historian of medicine than as a physician.

  9. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis.

    PubMed

    Chen, Yali; Honeychurch, Kady M; Yang, Guang; Byrd, Chelsea M; Harver, Chris; Hruby, Dennis E; Jordan, Robert

    2009-04-28

    Proteins associated with the late endosome (LE) appear to play a central role in the envelopment of a number of taxonomically diverse viruses. How viral proteins interact with LE-associated proteins to facilitate envelopment is not well understood. LE-derived transport vesicles form through the interaction of Rab9 GTPase with cargo proteins, and TIP47, a Rab9-specific effector protein. Vaccinia virus (VV) induces a wrapping complex derived from intracellular host membranes to envelope intracellular mature virus particles producing egress-competent forms of virus. We show that VV p37 protein associates with TIP47-, Rab9-, and CI-MPR-containing membranes. Mutation of a di-aromatic motif in p37 blocks association with TIP47 and inhibits plaque formation. ST-246, a specific inhibitor of p37 function, inhibits these interactions and also blocks wrapped virus particle formation. Vaccinia virus expressing p37 variants with reduced ST-246 susceptibility associates with Rab9 and co-localizes with CI-MPR in the presence and absence of compound. These results suggest that p37 localizes to the LE and interacts with proteins associated with LE-derived transport vesicle biogenesis to facilitate assembly of extracellular forms of virus.

  10. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis

    PubMed Central

    Chen, Yali; Honeychurch, Kady M; Yang, Guang; Byrd, Chelsea M; Harver, Chris; Hruby, Dennis E; Jordan, Robert

    2009-01-01

    Background Proteins associated with the late endosome (LE) appear to play a central role in the envelopment of a number of taxonomically diverse viruses. How viral proteins interact with LE-associated proteins to facilitate envelopment is not well understood. LE-derived transport vesicles form through the interaction of Rab9 GTPase with cargo proteins, and TIP47, a Rab9-specific effector protein. Vaccinia virus (VV) induces a wrapping complex derived from intracellular host membranes to envelope intracellular mature virus particles producing egress-competent forms of virus. Results We show that VV p37 protein associates with TIP47-, Rab9-, and CI-MPR-containing membranes. Mutation of a di-aromatic motif in p37 blocks association with TIP47 and inhibits plaque formation. ST-246, a specific inhibitor of p37 function, inhibits these interactions and also blocks wrapped virus particle formation. Vaccinia virus expressing p37 variants with reduced ST-246 susceptibility associates with Rab9 and co-localizes with CI-MPR in the presence and absence of compound. Conclusion These results suggest that p37 localizes to the LE and interacts with proteins associated with LE-derived transport vesicle biogenesis to facilitate assembly of extracellular forms of virus. PMID:19400954

  11. A learned artisan debates the system of the world: Le Clerc versus Mallemant de Messange.

    PubMed

    Rabinovitch, Oded

    2017-10-11

    Sébastien Le Clerc (1637-1714) was the most renowned engraver of Louis XIV's France. For the history of scientific publishing, however, Le Clerc represents a telling paradox. Even though he followed a traditional route based on classic artisanal training, he also published extensively on scientific topics such as cosmology and mathematics. While contemporary scholarship usually stresses the importance of artisanal writing as a direct expression of artisanal experience and know-how, Le Clerc's publications, and specifically the work on cosmology in his Système du monde (1706-1708), go far beyond this. By reconstructing the debate between Le Clerc and the professor Mallemant de Messange on the authorship of this 'system of the world', this article argues that Le Clerc's involvement in publishing ventures shaped his identity both as an artisan and as a scientific author. Whereas the Scientific Revolution supposedly heralded a change from the world of 'more or less' to the 'world of precision', this article shows how an artisan could be more 'precise' than the learned scholar whose claims he disputed, and points to the importance of the literary field as a useful lens for observing the careers of early modern scientific practitioners.

  12. Diffusion des macromolécules de dextrane dans le gel Séphadex G-200

    NASA Astrophysics Data System (ADS)

    Moussaoui, M.; Hamieh, T.; Toufaily, J.; Naoufal, D.

    2005-05-01

    Dans cet article nous avons étudié la diffusion des macromolécules de dextrane marquées à l'isothiocyanate de fluorescéine (FITC), dans les perles de l'ultrogel AcA34, par la méthode du retour de la fluorescence après photoblanchiment (FRAP). Le coefficient de partage chromatographique (Kc), a été déterminé par chromatographie sur une colonne de l'ultrogel AcA34. Le coefficient de partage microfluorimétrique (Kf) a été déterminé par la technique de (FRAP), en mesurant à la fois, la fluorescence dans la perle et dans le solvant. La relation entre le coefficient de partage chromatographique et le rayon de Stokes (Rs) des macromolécules a été étudiée en appliquant la relation de Laurent et Killender, alors que la variation du coefficient de diffusion relatif D/D0, a été étudiée en fonction de Kc en appliquant la théorie d'Ogston et al.

  13. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    SciTech Connect

    Riesselmann, A.; Baron, A.; Fregly, M.J. )

    1991-03-11

    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  14. Helen Primrose LeVesconte: occupational therapy clinician, educator, and maker of history.

    PubMed

    Friedland, Judith; Rais, Hadassah

    2005-06-01

    The Canadian history of our profession is not well known and our identity is thought to suffer as a result. Helen Primrose LeVesconte (7896-1982) is one pioneer in our development whose story has not been told. Our purpose is to explore LeVesconte's life and work in order to expand knowledge of our roots and thereby strengthen our identity. Using interpretive biography methods we draw on LeVesconte's own writings, articles written about her, and archival documents to describe turning point moments in her life and to display meaningful patterns in her work. LeVesconte's work as a clinician and her role and reputation as an educator, show her to have been a strong and visionary leader. Her views on the client's role, the importance of the therapist-client relationship, prevention, community-based programs, and vocational rehabilitation are of particular interest. Because LeVesconte educated over 1,850 students while director of the occupational therapy program at the University of Toronto, her influence has been felt throughout the country. Her perspective is compared to current practice; and questions are raised as to aspects of her legacy and philosophy that might now be reconsidered.

  15. Leishmaniose viscerale et leucemie aigüe lymphoblastique B: quel est le rapport?

    PubMed Central

    El Youssi, Hind; Touaoussa, Aziz; Bergui, Imane; Bougrine, Nawal; Amrani, Moncef Hassani

    2015-01-01

    L'association leishmaniose viscérale et leucémie aigue a été rarement rapportée dans la littérature, cependant le diagnostic concomitant de ces deux entités n'a jamais été rapporté au Maroc. Le lien entre ces deux pathologies n'a pas encore été établi et le traitement n'a pas encore été codifié. Nous rapportons le cas d'un garçon de 12 ans chez qui une leishmaniose viscérale et une leucémie aigue lymphoblastique type B ont été diagnostiquées simultanément. Malgré l'administration d'un traitement antiparasitaire associé à une chimiothérapie l’évolution était marquée par le décès du patient. PMID:26090011

  16. LeCDJ1, a chloroplast DnaJ protein, facilitates heat tolerance in transgenic tomatoes.

    PubMed

    Kong, Fanying; Deng, Yongsheng; Wang, Guodong; Wang, Jieru; Liang, Xiaoqing; Meng, Qingwei

    2014-01-01

    The roles of a tomato (Lycopersicon esculentum) chloroplast-targeted DnaJ protein (LeCDJ1) were investigated using wild-type (WT) and sense transgenic tomatoes. The LeCDJ1 expression was upregulated by 38 °C, 42 °C, 45 °C, NaCl, PEG, methyl viologen (MV) and hydrogen peroxide (H2O2), but not by 30 °C and 35 °C. Meanwhile, LeCDJ1 was involved in the response of plants to abscisic acid (ABA). Under heat stress, the sense plants showed better growth, higher chlorophyll content, lower malondialdehyde (MDA) accumulation and relative electrical conductivity (REC), and also less PSII photoinhibition than WT. Interestingly, the sense plants treated with streptomycin (SM), an inhibitor of organellar translation, still showed higher maximum photochemistry efficiency of PSII (Fv/Fm) and D1 protein levels than the SM-untreated WT, suggesting that the protective effect of LeCDJ1 on PSII was, at least partially, independent of D1 protein synthesis. Furthermore, the relatively lower superoxide radical (O2(•-)) and H2O2 levels in the sense plants were considered to be due to the higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) activity, which seemed unlikely dependent on their transcription level. These results indicated that LeCDJ1 overexpression facilitated heat tolerance in transgenic tomatoes. © 2013 Institute of Botany, Chinese Academy of Sciences.

  17. Amphibians and Reptiles of the state of Nuevo León, Mexico

    PubMed Central

    Lemos-Espinal, Julio A.; Smith, Geoffrey R.; Cruz, Alexander

    2016-01-01

    Abstract We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  18. Le naevus bleu cellulaire atypique du poignet: à propos d'un cas et revue de la literature

    PubMed Central

    Boussakri, Hassan; Roux, Jean Luc; Durand, Luc; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2014-01-01

    Le naevus bleu cellulaire atypique est une entité pathologique rare et sa localisation au niveau du poignet est exceptionnelle. Il est Considéré comme une Variante à des caractéristiques intermédiaires entre le naevus bleu cellulaire typique et le naevus bleu malin, dont l’évolution est incertaine. Le but de notre travail est d'attirer l'attention sur cette variété lésionnelle rare et de discuter les diagnostiques différentiels, ainsi que décrire les aspects histologique et les options thérapeutiques possibles. PMID:25426206

  19. Excision and duplication of su3+-transducing fragments carried by bacteriophage phi 80. I. Novel structure of phi 80sus2psu3+ DNA molecule.

    PubMed Central

    Yamagishi, H; Inokuchi, H; Ozeki, H

    1976-01-01

    DNA molecules of phi 80sus2psu3+ and phi 80dsu3+ isolated by Andoh and Ozeki (1968) were studied by the electron microscope heteroduplex method. The phi 80sus2psu3+ and phi 80dsu3+ DNA lengths were found to be 108.7 and 103.3% of the phi 80 DNA, respectively. The phi 80sus2psu3+/phi 80 heteroduplex shows an insertion loop of 8.7% of the phi 80 DNA which migrates from 7.7 to 9.7%, as measured relative to the left (0%) and right (100%) termini of the mature phi 80 DNA molecule. The region of loop migration occupies the central region of the phi 80 head gene cluster. The presence of su3+-containing Escherichia coli DNA of 6.7% phi 80 unit flanked by two homologous regions of phage DNA of 2.0% of phi 80 unit gives rise to a movable insertion loop. In phi 80dsu3+, from which phi 80sus2psu3+ was derived, 50.5% of the phi 80 DNA at the left arm was replaced by E. coli DNA containing the su3+ gene, equivalent to about 53.8% phi 80 unit in length. The phi 80sus2psu3+/phi 80dsu3+ heteroduplex appears as a double-stranded molecule that bifurcates into two clearly visible single-stranded regions, rejoins, bifurcates, and rejoins again. The middle double-stranded stretches of 6.7% phi 80 unit correspond to the E. coli DNA inserted in phi 80sus2psu3+. Therefore the transducing fragment carried by phi 80sus2psu3+ originates from the inside region of the transducing fragment of defective phage phi 80dsu3+ by at least two illegitimate recombination events. Images PMID:1271527

  20. "Panic": the impact of Le Bon's crowd psychology on U.S. military thought.

    PubMed

    Bendersky, Joseph W

    2007-01-01

    The controversial crowd psychology of Gustave Le Bon has been both praised as an incisive contribution to social theory and also condemned as a doctrine of irrationality and mass manipulation associated with fascism. New archival documentation now demonstrates that Le Bon exercised significant influence on U.S. military thinking and practice through World War II. Army writings and officer training on morale, leadership, and battlefield psychology rested substantially on his theory of crowds, particularly regarding races and panic. Le Bon's racial psychology took on additional importance when the African-American 92 nd Infantry Division panicked during combat in Italy. This new evidence offers an excellent case study of the direct and enduring impact of a peculiar type of social psychology on the institutional culture of the army from the classrooms at the Army War College to the battlefield itself. (c) 2007 Wiley Periodicals, Inc.

  1. à quoi doit servir le patrimoine astronomique français?

    NASA Astrophysics Data System (ADS)

    Caplan, J.; Vila, B.

    2012-12-01

    Les deux auteurs, l'un astronome l'autre botaniste (et chargé de mission patrimoine de l'université d'Aix-Marseille), présentent quelques idées sur la gestion des collections historiques d'astronomie, dans un contexte universitaire. Nous mettons en avant la spécificité de ces collections par rapport à celles des musées traditionnels et leur importance pour l'histoire des sciences notamment. Nous rappelons également la nécessité de suivre la déontologie muséale soutenue par l'association Universeum, réseau européen pour le patrimoine universitaire. Enfin nous rappelons lele essentiel que jouent les réserves et la nécessité de travailler en collaboration.

  2. Quand le bloc axillaire reste la seule alternative chez un enfant de 5 ans

    PubMed Central

    Nakhli, Mohamed Said; Béjaoui, Nawel; Naija, Walid; Mhamdi, Salah; Said, Rachid

    2015-01-01

    Le bloc axillaire par neurostimulation chez l'enfant n'est pas une technique habituelle, surtout avec le développement des techniques d'anesthésie locorégionale échoguidées. Cependant elle peut être une alternative intéressante si l'anesthésie générale est a risque voir même contre indiquée. Nous rapportons le cas d'un bloc axillaire anesthésique chez un enfant de 5 ans porteur d'un kyste hydatique du poumon et une hépatite A sévère proposé pour une fixation de fracture du condyle externe de l'humérus. PMID:26405472

  3. Developmental History of Liquid Oxygen Turbopumps for the LE-7 Engine

    NASA Astrophysics Data System (ADS)

    Kamijo, Kenjiro; Yamada, Hitoshi; Sakazume, Norio; Warashina, Shogo

    The first stage of the H-2 rocket used a 110-ton thrust liquid oxygen, liquid hydrogen, pump-fed engine, the LE-7. This engine required high-pressure and high-power liquid oxygen and liquid hydrogen turbopumps to achieve the two-stage combustion cycle in which the combustion pressure is around 13 MPa. Furthermore, it was very important to operate both turbopumps at higher rotational speeds to obtain a smaller, lighter-weight engine because the LE-7 had not low-speed, low-pressure pumps ahead of both the main pumps. The present paper shows the design, test results, and modifications that had been performed until a flight-type liquid oxygen turbopump for the LE-7 engine was completed. The liquid oxygen turbopump had been developed by the use of three models, that is, research, prototype, and flight models.

  4. Le syndrome d'Othello: un cas observé à Ouagadougou

    PubMed Central

    Kaboré, Bawindsongré Jean; Napon, Christian

    2013-01-01

    Les auteurs rapportent le premier cas de délire de jalousie encore décrit sous l'acronyme de syndrome d'Othello, à Ouagadougou. Il s'est agit d'un patient qui au décours d'un accident vasculaire cérébral ischémique constitué, a développé un délire de jalousie. Une revue de la littérature permet de comprendre que l'affection, rarement rapportée est de plus en plus décrite au décours de maladies neurologiques aigues ou chroniques, et que le lobe frontal joue vraisemblablement un rôle majeur. PMID:24570777

  5. A CYTOCHEMICAL STUDY OF THE L.E. BODIES OF SYSTEMIC LUPUS ERYTHEMATOSUS

    PubMed Central

    Godman, Gabriel C.; Deitch, Arline D.

    1957-01-01

    Microspectrophotometric comparison of lymphocyte nuclei and free L.E. bodies which are derived from them show a more than twofold average increase in the latter of protein basic groups revealed by naphthol yellow S binding, and tyrosine residues demonstrated by the Millon reaction. The alkaline fast green method for histones and the Sakaguchi reaction for arginine residues suggest that there is a marked loss and ultimate disappearance of histones in the course of formation of the L.E. body from a nucleus. It is postulated that the L.E. transformation entails influx of protein normally foreign to the nucleus, displacement of histone from combination of DNA, and association of the DNA with the new protein which is then responsible for masking the anionic groups of DNA. PMID:13475616

  6. Le Fort I Osteotomy with Bone Grafts in Preprosthetic Surgery: Technical Note

    PubMed Central

    Pingarron-Martin, Lorena; Arias-Gallo, Javier; Ong, Hui Shan; Pons, Manuel Chamorro

    2013-01-01

    Background Being edentulous causes progressive bony resorption in maxillae, which can lead to altered maxillomandibular relationships. Discussion should consider Le Fort I osteotomy with inlay grafts for a better success rate. Thus, this article introduces a technical note in improving the success rate. Case Report The presented technical note permits transformation of the surgery in a conventional Le Fort I with a simple fixation not only of the grafts but also of the osteotomy. The surgical steps are explained as well as the follow-up results. Discussion Adding additional wire anchorage around bone grafts greatly improved our success rate and reduced our operative time. Bone grafting concurrently with Le Fort I osteotomy immediately improved the facial skeletal profile. Several in vitro studies have shown that galvanic corrosion does not play a significant role when combining stainless steel and titanium. Our novel technique is relatively simple and can be easily picked up by young surgeons. PMID:24436751

  7. Le conflit fémoro-acétabulaire et la coxarthrose

    PubMed Central

    Zhang, Charlie; Li, Linda; Forster, Bruce B.; Kopec, Jacek A.; Ratzlaff, Charles; Halai, Lalji; Cibere, Jolanda; Esdaile, John M.

    2015-01-01

    Objectif Expliquer la présentation clinique, les observations à l’examen physique, les critères diagnostiques et les options de prise en charge du conflit fémoroacétabulaire (CFA). Sources des données Une recherche documentaire a été effectuée dans PubMed pour trouver des articles pertinents sur la pathogenèse, le diagnostic, le traitement et le pronostic du CFA. Message principal Depuis les dernières années, on reconnaît de plus en plus que le CFA est un précurseur potentiel et une étiologie importante des douleurs à la hanche dans la population adulte et de la coxarthrose idiopathique plus tard dans la vie. Le conflit fémoro-acétabulaire désigne un ensemble d’anomalies morphologiques osseuses de l’articulation de la hanche qui se traduit par un contact anormal durant le mouvement. Le CFA par effet came concerne une proéminence osseuse non sphérique du col fémoral proximal ou de la jonction tête-col. Le CFM par effet tenaille désigne une couverture acétabulaire excessive par-dessus la tête du fémur, qui peut se produire en raison de diverses variantes morphologiques. Les patients qui ont un CFA présentent une douleur inguinale antérieure chronique, profonde ou lancinante, le plus souvent en position assise, durant ou après une activité. Les patients peuvent aussi ressentir des douleurs occasionnelles aiguës durant l’activité. Il faut procéder à une anamnèse approfondie portant notamment sur l’incidence de traumatismes ou la fréquence de l’exercice. Il faut aussi faire un examen physique complet des hanches, de la région lombaire et de l’abdomen pour évaluer d’autres causes de douleurs inguinales antérieures. Le diagnostic de CFA est confirmé par radiographie. Le conflit fémoro-acétabulaire peut être pris en charge selon une approche conservatrice comportant du repos, la modification des activités, des médicaments et de la physiothérapie ou encore être traité par intervention chirurgicale. Conclusion

  8. Progress on the Development of Two-Dimension Eulerian-Lagrangian Code LeFIX

    SciTech Connect

    Sunchai, Nilsuwankosit; IkKyu, Park; JinHo, Song

    2006-07-01

    In order to improve on the analysis and the simulation of the process of fuel-coolant interaction, a code capable of simulating the motions of the fuel particles and two phases of the fluid is considered. Based on the old two-fluid code called K-FIX and LeSiM, the newly developed set of subroutines to simulate the motion and the interaction of the Lagrangian particles, the new two-dimension two-fluid thermal hydraulic code called LeFIX is being developed. For solving the conservation equations, the algorithm employed by LeFIX was modified from that used in K-FIX. However, since the correlations for liquid-vapor heat transfer coefficients in droplet and bubbly flows together with the drag coefficient between two phases of the fluid in the same flow scheme had not been modeled in KFIX, they were specifically implemented. In addition, the simplified functions specifying the properties of the liquid water and the steam were also introduced. Currently, LeFIX was verified to give the results identical to that of K-FIX when they were run under the condition where each phase of the fluid were incompressible, with constant but very high heat and momentum transfer rates. In this specific work, LeFIX was tested for the condition in which the steam bubbles gradually rose in the cylindrical volume filled with the subcooled liquid water. The obtained results showed that LeFIX could reasonably well simulate the motion by each phase of the fluid and also their interactions. With the models for the fluid being completed, testing the interaction of the two-phase fluid with the Lagrangian particles is to be the next stage of the development. (authors)

  9. Hemoglobin Le Lamentin in the province of Albacete, Spain: Discovery of 32 cases.

    PubMed

    Martínez-López, Rosalina; Ropero, Paloma; Ballesteros Gallar, Cristina; Romero Román, Carlos; de la Fuente-Gonzalo, Félix; M Nieto, Jorge; Navarro Casado, Laura; González, Fernando A

    2017-03-01

    Hemoglobin Le Lamentin (α20(B1)His→Gln) is a ubiquitous variant that has been previously described in a small number of isolated patients. We report the incidental observation of Hb Le Lamentin in a large population from the province of Albacete, in southeastern Spain. Our study investigates possible reasons for the elevated number of carriers of this variant and its implications for the management of diabetes in our region. The subjects are 32 diabetic patients whose hemoglobin displayed an unusual peak while they were being tested for glycated hemoglobin at the laboratory of the University General Hospital of Albacete over a 3-year period. Measurements were made by high performance liquid chromatography using a Variant™ II Turbo Kit-2.0, and subsequently the samples of the 32 patients with anomalous peaks were sent to the Hospital Clínico San Carlos (Madrid, Spain) for molecular characterization of any Hb variants. Molecular studies revealed 31 out of 32 patients heterozygous for Le Lamentin, and in one of them, Hb City of Hope was associated with Hb Le Lamentin. The remaining patient was homozygous for the Le Lamentin mutation. Additionally, most patients were native to the northeastern half of the province of Albacete and were unrelated. Our study describes the largest finding to date of hemoglobin Le Lamentin in a sample of patients. The fact that our region has been perpetually depopulated, with a population that has remained stable in small localities over the centuries, may have favored the survival of the mutation. Since the presence of this variant underestimates the true value of glycated hemoglobin measured by HPLC, it is necessary to systematically review chromatograms. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  10. Infection par le virus de l’hépatite E durant la grossesse

    PubMed Central

    Chaudhry, Shahnaz A.; Verma, Natasha; Koren, Gideon

    2015-01-01

    Résumé Question Plusieurs de mes patientes sont originaires de l’Asie du Sud-Est où le virus de l’hépatite E est assez commun. Quelles précautions puis-je leur suggérer de prendre avant de voyager dans cette région et quels sont les risques d’une infection par le VHE durant la grossesse? Réponse L’hépatite E est un pathogène présent dans l’eau qui se transmet par voie oro-fécale. Afin de réduire le risque de contracter le VHE lors de voyages dans des régions endémiques, il est important de maintenir des pratiques d’hygiène telles que se laver les mains avec de l’eau potable, particulièrement avant de manipuler de la nourriture, éviter de boire de l’eau ou d’utiliser des glaçons de pureté inconnue et ne pas manger de fruits ou de légumes non pelés. Actuellement, il n’existe aucun vaccin disponible au Canada pour le VHE. Une infection à l’hépatite E durant la grossesse, surtout durant le troisième trimestre, se caractérise par une infection plus sévère qui se transforme parfois en hépatite fulminante, augmentant ainsi les risques de mortalité et de morbidité maternelles et fœtales.

  11. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  12. Causes de décès des patients infectés par le VIH dans le Centre tunisien

    PubMed Central

    Chelli, Jihène; Bellazreg, Foued; Aouem, Abir; Hattab, Zouhour; Mesmia, Hèla; Lasfar, Nadia Ben; Hachfi, Wissem; Masmoudi, Tasnim; Chakroun, Mohamed; Letaief, Amel

    2016-01-01

    La trithérapie antirétrovirale a contribué à une baisse considérable de la mortalité liée au VIH. Les causes de décès sont dominées par les infections opportunistes dans les pays en voie de développement et par les maladies cardiovasculaires et les cancers dans les pays développés. L’objectif était de déterminer les causes et les facteurs de risque de décès des patients infectés par le VIH dans le Centre Tunisien. Une étude transversale auprès des patients infectés par le VIH âgés de plus de 15 ans suivis à Sousse et à Monastir entre 2000 et 2014. Le décès était considéré lié au VIH si la cause était un évènement classant SIDA ou s’il était la conséquence d’une infection opportuniste d’étiologie indéterminée avec des CD4 < 50/mm3, non lié au VIH si la cause n’était pas un évènement classant SIDA, et de cause inconnue si aucune information n’était disponible. Deux cents treize patients, 130 hommes (61%) et 83 femmes (39%), d’âge moyen 40±11 ans ont été inclus. Cinquante quatre patients sont décédés, avec une mortalité de 5,4/100 patients-années. La mortalité annuelle a baissé de 5,8% en 2000-2003 à 2,3% en 2012-2014. La survie était de 72% à 5 ans et de 67% à 10 ans. Les décès étaient liés au VIH dans 70,4% des cas. Les causes de décès les plus fréquentes étaient la pneumocystose pulmonaire et la cryptococcose neuroméningée dans 6 cas (11%) chacune. Les facteurs de risque de décès étaient les antécédents d’infections opportunistes, la durée de la trithérapie antirétrovirale < 12 mois et le tabagisme. Le renforcement du dépistage, l’initiation précoce de la trithérapie antirétrovirale, et la lutte contre le tabagisme sont nécessaires afin de réduire la mortalité chez les patients infectés par le VIH en Tunisie. PMID:28292068

  13. le de la radiothérapie dans le traitement de l'améloblastome: à propos de deux cas

    PubMed Central

    El Mazghi, Abderrahman; Bouhafa, Touria; El Kacemi, Hanan; Loukili, Kaoutar; Chbani, Laila; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Lele de la radiothérapie dans son traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L’évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans. PMID:25722762

  14. Phenotype and animal domestication: A study of dental variation between domestic, wild, captive, hybrid and insular Sus scrofa.

    PubMed

    Evin, Allowen; Dobney, Keith; Schafberg, Renate; Owen, Joseph; Vidarsdottir, Una Strand; Larson, Greger; Cucchi, Thomas

    2015-02-04

    Identifying the phenotypic responses to domestication remains a long-standing and important question for researchers studying its early history. The great diversity in domestic animals and plants that exists today bears testament to the profound changes that domestication has induced in their ancestral wild forms over the last millennia. Domestication is a complex evolutionary process in which wild organisms are moved to new anthropogenic environments. Although modern genetics are significantly improving our understanding of domestication and breed formation, little is still known about the associated morphological changes linked to the process itself. In order to explore phenotypic variation induced by different levels of human control, we analysed the diversity of dental size, shape and allometry in modern free-living and captive wild, wild x domestic hybrid, domestic and insular Sus scrofa populations. We show that domestication has created completely new dental phenotypes not found in wild boar (although the amount of variation amongst domestic pigs does not exceed that found in the wild). Wild boar tooth shape also appears to be biogeographically structured, likely the result of post-glacial recolonisation history. Furthermore, distinct dental phenotypes were also observed among domestic breeds, probably the result of differing types and intensity of past and present husbandry practices. Captivity also appears to impact tooth shape. Wild x domestic hybrids possess second molars that are strictly intermediate in shape between wild boar and domestic pigs (third molars, however, showing greater shape similarity with wild boar) while their size is more similar to domestic pigs. The dental phenotypes of insular Sus scrofa populations found on Corsica and Sardinia today (originally introduced by Neolithic settlers to the islands) can be explained either by feralization of the original introduced domestic swine or that the founding population maintained a wild boar

  15. Technology for Evolutionary Software Development (Technologies pour le developpement de logiciels evolutifs)

    DTIC Science & Technology

    2003-06-01

    performs its mission with the support of an extensive network of national experts. It also ensures effective coordination with other NATO bodies involved in...intégré unique pour le matériel, le logiciel et la logistique . La session sur les stratégies et les approches, qui était axée sur un système...development process.3 • Requirements Engineering – Quality, Performance and Cost requirements quantified. Evolutionary development can be viewed as a

  16. Le glaucome congénitale et la neurofibromatose type 1

    PubMed Central

    Tzili, Nazih; El Orch, Hamza; Bencherifa, Fatiha; Chefchaouni, Mohammed Charif; Abdallah, El Hassan; Berraho, Amina

    2015-01-01

    Le glaucome congénital constitue une complication ophtalmologique dans la neurofibromatose type 1 ou maladie de von Recklinghausen. Nous rapportons un cas de glaucome congénitale dans le cadre d'une neurofibromatose de type 1, à travers lequel on va discuter les mécanismes étiopathogénique, les difficultés thérapeutiques et les facteurs pronostiques du glaucome congénital au cours la maladie de von Recklinghausen avec revue de la littérature. PMID:26405492

  17. Conductivite dans le modele de Hubbard bi-dimensionnel a faible couplage

    NASA Astrophysics Data System (ADS)

    Bergeron, Dominic

    Le modele de Hubbard bi-dimensionnel (2D) est souvent considere comme le modele minimal pour les supraconducteurs a haute temperature critique a base d'oxyde de cuivre (SCHT). Sur un reseau carre, ce modele possede les phases qui sont communes a tous les SCHT, la phase antiferromagnetique, la phase supraconductrice et la phase dite du pseudogap. Il n'a pas de solution exacte, toutefois, plusieurs methodes approximatives permettent d'etudier ses proprietes de facon numerique. Les proprietes optiques et de transport sont bien connues dans les SCHT et sont donc de bonne candidates pour valider un modele theorique et aider a comprendre mieux la physique de ces materiaux. La presente these porte sur le calcul de ces proprietes pour le modele de Hubbard 2D a couplage faible ou intermediaire. La methode de calcul utilisee est l'approche auto-coherente a deux particules (ACDP), qui est non-perturbative et inclue l'effet des fluctuations de spin et de charge a toutes les longueurs d'onde. La derivation complete de l'expression de la conductivite dans l'approche ACDP est presentee. Cette expression contient ce qu'on appelle les corrections de vertex, qui tiennent compte des correlations entre quasi-particules. Pour rendre possible le calcul numerique de ces corrections, des algorithmes utilisant, entre autres, des transformees de Fourier rapides et des splines cubiques sont developpes. Les calculs sont faits pour le reseau carre avec sauts aux plus proches voisins autour du point critique antiferromagnetique. Aux dopages plus faibles que le point critique, la conductivite optique presente une bosse dans l'infrarouge moyen a basse temperature, tel qu'observe dans plusieurs SCHT. Dans la resistivite en fonction de la temperature, on trouve un comportement isolant dans le pseudogap lorsque les corrections de vertex sont negligees et metallique lorsqu'elles sont prises en compte. Pres du point critique, la resistivite est lineaire en T a basse temperature et devient

  18. Emergency removal of a grinding wheel embedded in the midface via modified Le Fort I osteotomy.

    PubMed

    Jiang, W H; Wang, X D; Shen, G F

    2011-04-01

    Le Fort I osteotomy is commonly used to rectify craniofacial deformity in orthognathic surgery and it can be used in approaching a cranial base lesion. This technique has not been well documented in craniofacial penetrating trauma. This article describes a case of midface penetrating injury caused by a grinding wheel. A modified Le Fort I osteotomy was used to remove the foreign object. This surgical approach can be safe and effective when removing foreign bodies in the midface. Good access and adequate exposure can be achieved, which facilitate precise foreign body extraction and achieve reasonable cosmetic results.

  19. Le cancer en milieu chirurgical pédiatrique au Togo

    PubMed Central

    Gnassingbe, Komla; Guedenon, Koffi Mawuse; Kanassoua, Kokou; Adabra, Komlan; Kpabi, Kagnimtassou; Akakpo-Numado, Gamedzi Komlatse; Napo-Koura, Gado; Tekou, Hubert

    2014-01-01

    Introduction Le but de ce travail était de relever les aspects épidémiologiques des cancers de l'enfant en milieu chirurgical, décrire les problèmes posés par ces cancers et évaluer les résultats de leur prise en charge Méthodes Il s'agit d'une étude rétrospective analytique sur dossiers de patients âgés de moins de 15 ans pris en charge dans le service de chirurgie pédiatrique pour cancer solide de preuve anatomopathologique entre janvier 1987 et décembre 2010. Jusqu'en 2010, les hôpitaux publics du Togo ne disposaient pas d'imagerie par résonance magnétique ni de la tomodensitométrie. Il n'existe pas de service d'oncologie pédiatrique, ni de radiothérapie au Togo. Depuis quelques années maintenant, le Togo a intégré le Groupe Franco Africain d'oncologie Pédiatrique (GFAOP) et les patients bénéficient gracieusement des antimitotiques pour la prise en charge de certains cancers. Résultats Trente un patients avaient été pris en charge dans le service de chirurgie pédiatrique pour cancer. Parmi eux, il y avait 18 garçons (58,06%) et 15 filles (41,94%). L’âge moyen des patients était de 7,62 ans (extrêmes: 3 mois et 15 ans). Les patients étaient également répartis dans les différentes tranches d’âge. Les circonstances de découverte variaient selon le type de tumeurs. Les tumeurs des tissus mous représentaient 51,61% des cas, les tumeurs germinales 25,81% des cas et les tumeurs osseuses 22,58% des cas. Le délai moyen d’évolution avant la consultation était de 4,6 mois (extrêmes: 2 et 14 mois). Le taux de décès était de 54,84% des cas. Conclusion Les cancers solides de l'enfant sont caractérisés par un retard à la consultation et un plateau à visée diagnostique et thérapeutique très limité entrainant de ce fait une forte mortalité. PMID:25161753

  20. Interpretation des donnees de flux de chaleur et de gravite dans le bouclier Canadien

    NASA Astrophysics Data System (ADS)

    Cheng, Li Zhen

    2000-10-01

    Le champ geothermique du Bouclier Canadien est caracterise par un flux moyen de 41 mW·m-2, qui suggere une production de chaleur moyenne dans la croute comprise entre 0.7 et 0.8 muW·m-3. Le flux de chaleur relativement faible favorise la stabilite du bouclier et lui a permis de resister a la deformation tectonique. Les variations du flux de chaleur a la surface sont dominees par la composition de la croute. Un flux eleve implique generalement une composition felsique et il est d'autant plus faible que la croute devient plus mafique. La production de chaleur en surface n'est pas representative de la production moyenne de la croute. Le flux de chaleur dans le Boucher Canadien ne depend donc pas de la production de chaleur en surface, mais depend de la composition principale de la croute. L'interpretation combinee des donnees geophysiques nous permet de determiner les variations de composition d'echelle crustale a partir desquelles il est possible d'etablir la structure de la croute. L'etude detaillee de l'Orogene de Trans-Hudson et de la Sous-province d'Abitibi a montre que le flux de chaleur, la gravite et la sismique lorsqu'elles sont combinees fournissent des contraintes efficaces pour determiner l'architecture crustale. En general, la croute est trop resistante pour se deformer par fluage, excepte tres localement. Le mode de deformation de la lithosphere continentale depend de la composition et du gradient geothermique. Nous montrons que la lithosphere du Bouclier Canadien demeure principalement fragile jusqu'a une profondeur de plus de 150 km. Une deformation ductile pourrait cependant etre possible localement a la base de la, croute, comme dans la ceinture de Thompson par exemple. Si l'on admet que la lithosphere peut resister a des contraintes allant jusqu'a 20 MPa (taux de deformation 3˙ < 10-15 s-1), l'epaisseur de la lithosphere est de l'ordre de 300 km pour la ceinture de Thompson et est superieure a 300 km pour la sous-province d'Abitibi. La resistance

  1. Volatile emission of decomposing pig carcasses (Sus scrofa domesticus L.) as an indicator for the postmortem interval.

    PubMed

    Paczkowski, Sebastian; Nicke, Sara; Ziegenhagen, Henrik; Schütz, Stefan

    2015-01-01

    This study aimed at correlating selected carcass borne volatile organic compounds (VOCs) with the postmortem interval (PMI). Selected volatiles should 1st be reliably emitted during vertebrate decay, 2nd be emitted at high concentrations, and 3rd show a reproducible quantitative dynamic during the decaying process. Four pigs (Sus scrofa domesticus L.) were placed in a deciduous forest in different seasons and volatiles emitted during the decaying process were sampled. Seventeen compounds were identified and quantified by GC-MS. Electrophysiological experiments on the antenna of female Calliphora vicina and additional data of Dermestes maculans were used as an evolutionary tuned information filter to evaluate the 1st criterion. The relative quantitative emission of hexanal, nonanal, dimethyl disulfide, dimethyl trisulfide, 1-butanol, and phenol were correlated with the PMI, and the observed stages of decay and the limitations of this model were discussed.

  2. Seroprevalence of Trichinella sp. in Wild Boars (Sus scrofa) from Yanggu-gun, Gangwon-do, Korea.

    PubMed

    Lee, Hye-Jung; Chung, Ok-Sik; Kim, Jae-Lip; Lee, Seung-Ha; Yoo, Young-Bok; Seo, Min

    2015-04-01

    A total 7 outbreaks of trichinellosis have occurred in Korea, mostly as a result of consumption of raw wild boar (Sus scrofa) meat. Since only 1 serological survey on wild boars had yet been performed in Korea, the present study aimed to estimate the prevalence of trichinellosis in wild boars and some species of rodents by artificial digestion and serological examinations in Yanggu-gun, Gangwon-do, the endemic area of trichinellosis. Both the wild boar and rodent muscle samples revealed no Trichinella larvae by direct examination and artificial digestion method. However, serological examinations revealed that 4 wild boar sera samples out of 118 (3.4%) were positive to Trichinella antigen. Although the recovery of Trichinella larvae ended in a failure, it is proved for the first time that the sylvatic cycle of Trichinella has been maintained in wild boars of Gangwon-do, Korea.

  3. Multiple Origins and Admixture of Recently Expanding Japanese Wild Boar (Sus scrofa leucomystax) Populations in Toyama Prefecture of Japan.

    PubMed

    Yamazaki, Yuji; Adachi, Fuminari; Sawamura, Akira

    2016-02-01

    Japanese wild boar (Sus scrofa leucomystax) populations have expanded drastically throughout the Japanese Archipelago in recent decades. To elucidate the dispersal patterns of Japanese wild boar in Toyama Prefecture in central Japan, we used a multi-locus microsatellite DNA analysis to determine its population structure and the degree of admixture. The deviation from Hardy-Weinberg equilibrium was detected in either total or separate regional wild boar samples from Toyama Prefecture. This result could be explained by the Wahlund effect resulting from the mixture of samples from different sources. Bayesian structure analysis, assignment test, and factorial correspondence analysis suggested that wild boars around Toyama Prefecture derive from at least two ancestral sources. The migration and possible mating of each individual may have occurred recently and continued in each geographically neighboring region. The present genetic results may be useful for prediction of future dispersal patterns of Japanese wild boar, as well as other animals in expansion.

  4. Seroprevalence of Toxoplasma gondii in wild boars (Sus scrofa leucomystax) and wild sika deer (Cervus nippon) in Gunma Prefecture, Japan.

    PubMed

    Matsumoto, Jun; Kako, Yune; Morita, Yukio; Kabeya, Hidenori; Sakano, Chieko; Nagai, Akira; Maruyama, Soichi; Nogami, Sadao

    2011-09-01

    The ingestion of undercooked meat from wild animals can be a source of Toxoplasma gondii infection in humans and other animals. In this study, we determined the seroprevalence of T. gondii infection in 175 wild boars (Sus scrofa leucomystax) and 107 wild sika deer (Cervus nippon) hunted in 2004-2007 in Gunma Prefecture, Japan, by using a commercial latex agglutination test (LAT). Antibodies (LAT, 1:64 or higher) to T. gondii were found in 6.3% of wild boars and 1.9% of sika deer. This is the first record of T. gondii infection in wild deer in Japan, and deer and wild boar meat should be cooked well before human consumption. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  5. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Göttingen Minipigs (Sus scrofa domestica)

    PubMed Central

    Pils, Marina C; Dreckmann, Karla; Jansson, Katharina; Glage, Silke; Held, Nadine; Sommer, Wiebke; Länger, Florian; Avsar, Murat; Warnecke, Gregor; Bleich, André

    2016-01-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) infection was diagnosed in 6 Göttingen minipigs (Sus scrofa domestica) with severe interstitial pneumonia. The virus was defined as a North American (NA) subtype virus, which is common in the commercial pig population and might be derived from a widely used attenuated live-virus vaccine in Europe. The ORF5 sequence of the isolated PRRSV was 98% identical to the vaccine virus. The affected pigs were part of a lung transplantation model and received tacrolimus and steroids as well as irradiation or CD8 antibody for immunosuppression. The likely source of the infection was pigs that were shedding the identified PRRSV, which were housed in a separate room of the same building. This case report provides evidence that a virus closely related to an attenuated live vaccine might cause severe pneumonia and death in PRRSV-seronegative pigs receiving immunosuppressive treatment. We recommend strict barrier housing for immunocompromised pigs. PMID:27780006

  6. Multiplex serology for common viral infections in feral pigs (Sus scrofa) in Hawaii between 2007 and 2010.

    PubMed

    Stephenson, Rachel J; Trible, Benjamin R; Wang, Yu; Kerrigan, Maureen A; Goldstein, Samuel M; Rowland, Raymond R R

    2015-01-01

    Multiplex serology was performed for the detection of total immunoglobulin (Ig) and IgM antibodies against porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and swine influenza virus (SIV) antigens in feral swine (Sus scrofa). Serum samples were collected from the islands of Oahu (292 pigs) and Hawaii (52 pigs) between 2007 and 2010. The highest antibody prevalence was to PCV2 (63%), followed by SIV (7.8%) and PRRSV (5.8%). Antigen-specific IgM was detected at a much lower prevalence. PCR amplification and sequence analysis of PCV2 in three IgM-positive samples identified PCV2b as the only genotype. While the prevalence of PCV2 and PRRSV remained similar between 2007 and 2010, the percentage of SIV-positive samples on Oahu increased from 2% to 19%. Our results demonstrate the utility of multiplex serology for pathogen surveillance in feral pig populations.

  7. Spargana in a Weasel, Mustela sibirica manchurica, and a Wild Boar, Sus scrofa, from Gangwon-do, Korea

    PubMed Central

    Lee, Seung-Ha; Choe, Eun-Yoon; Shin, Hyun-Duk

    2013-01-01

    To know the status of sparganum (plerocercoid of Spirometra erinacei) infection in the Korean wild life, several species of wild animals were captured in Gangwon-do and examined for their status of infection with spargana. From February to December 2011, a total of 62 wild boars, 5 badgers, 1 weasel, 1 Siberian chipmunk, and 53 wild rodents were captured, and their whole muscles were examined with naked eyes for the presence of spargana worms. From the weasel and 1 wild boar, a total of 5 spargana specimens were extracted. The weasel was for the first time recorded as an intermediate or paratenic/transport host of S. erinacei in Korea, and both the weasel (Mustela sibirica manchurica) and wild boar (Sus scrofa) were added to the list of wild animals carrying spargana. PMID:23864753

  8. Spargana in a weasel, Mustela sibirica manchurica, and a wild boar, Sus scrofa, from Gangwon-do, Korea.

    PubMed

    Lee, Seung-Ha; Choe, Eun-Yoon; Shin, Hyun-Duk; Seo, Min

    2013-06-01

    To know the status of sparganum (plerocercoid of Spirometra erinacei) infection in the Korean wild life, several species of wild animals were captured in Gangwon-do and examined for their status of infection with spargana. From February to December 2011, a total of 62 wild boars, 5 badgers, 1 weasel, 1 Siberian chipmunk, and 53 wild rodents were captured, and their whole muscles were examined with naked eyes for the presence of spargana worms. From the weasel and 1 wild boar, a total of 5 spargana specimens were extracted. The weasel was for the first time recorded as an intermediate or paratenic/transport host of S. erinacei in Korea, and both the weasel (Mustela sibirica manchurica) and wild boar (Sus scrofa) were added to the list of wild animals carrying spargana.

  9. Helminth parasites of the wild boar, Sus scrofa, in Luristan province, western Iran and their public health significance.

    PubMed

    Solaymani-Mohammadi, S; Mobedi, I; Rezaian, M; Massoud, J; Mohebali, M; Hooshyar, H; Ashrafi, K; Rokni, M B

    2003-09-01

    Seven helminth species were obtained from 12 wild boars (Sus scrofa) during a survey from 2000 to 2001 in Luristan province, western Iran. These species include the cestode larvae Cysticercus tenuicollis (25%), C. cellulosae (8.3%), the nematodes Metastrongylus apri (41.6%), M. pudendotectus (16.6%), M. salmi (8.3%), Trichuris suis (8.3%) and the acanthocephalan Macracanthorhynchus hirudinaceus (41.6%). No trematodes were found. Seven wild boars (58.3%) were identified as having at least one helminth species. A single infection was detected in 16.6% of cases, but a three species infection covered the highest rank (25%). All these helminths have been reported from other areas of Iran including the north, northeast and southwest, but not in Luristan. Among seven helminths identified, at least three species are transmissible to humans. The public health significance of these helminths is discussed.

  10. δ18O values of Sus scrofa blood water and bone phosphate; a marked discrepancy between domestic and wild specimens.

    PubMed

    Longinelli, Antonio; Selmo, Enrico

    2011-12-30

    δ¹⁸O analyses of water in the blood of domestic and wild pigs indicated that large isotopic differences exist between domestic and wild specimens of the same species (Sus scrofa) living in the same area. Similar isotopic differences are found between the δ¹⁸O(PO₄³⁻) values of bones from the two groups of animals. When δ¹⁸O values obtained from recent wild boar bones are introduced in the equation of the isotopic scale determined for domestic pigs, totally unreliable δ¹⁸O values of local meteoric water are obtained. The δ¹⁸O(PO₄³⁻) values measured in three groups of modern wild boar specimens allow the calculation of a first approximate equation which is quite different from that of domestic pigs. This isotopic scale should be accurately re-calibrated for wild animals.

  11. The genetic impact of demographic decline and reintroduction in the wild boar (Sus scrofa): a microsatellite analysis.

    PubMed

    Vernesi, C; Crestanello, B; Pecchioli, E; Tartari, D; Caramelli, D; Hauffe, H; Bertorelle, G

    2003-03-01

    The reintroduction of wild boar from central Europe after World War II has contributed substantially to the range expansion of this species in Italy, where indiscriminate hunting in earlier times resulted in extreme demographic reduction. However, the genetic impact of such processes is not well-understood. In this study, 105 individuals from Italian and Hungarian wild boar populations were characterized for nine autosomal microsatellite loci. The Hungarian samples, and two central Italian samples from protected areas (parks) where reintroduction is not documented, were assumed to be representative of the genetic composition of the source and the target populations in the reintroduction process, respectively. Animals hunted in the wild in the Florence area of Tuscany (Italy) were then studied to identify the effects of reintroduction. The results we obtained can be summarized as follows: (i) none of the populations analysed shows genetic evidence of demographic decline; (ii) the three parental populations from Italy and Hungary are genetically distinct; however, the low level of divergence appears in conflict with the naming of the Italian and the European subspecies (Sus scrofa majori and Sus scrofa scrofa, respectively); in addition, the Italian groups appear to be as divergent from each other as they are from the Hungarian population; (iii) most of the individuals hunted near Florence are genetically intermediate between the parental groups, suggesting that hybridization has occurred in this area, the average introgression of Hungarian genotypes is 13%, but approximately 45% of the genetic pool of these individuals can not be directly attributed to any of the parental populations we analysed; (iv) analysis of microsatellite loci, though in a limited number, is an important tool for estimating the genetic effect of reintroduction in the wild boar, and therefore for the development of conservation and management strategies for this species.

  12. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  13. The Center for Learning Technologies in Urban Schools (LeTUS) Program[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The "LeTUS" program is a three-year, project-based, technology-integrated middle school science curriculum for grades 6-8. The "LeTUS" program is composed of multiple units, each lasting between eight and ten weeks. Topics include global warming, water and air quality, force and motion, communicable diseases, and ecological…

  14. Pour Une Poesie Chretienne a L'age Baroque: Mysticisme, Heroisme et Feminisme Chez Pierre Le Moyne 1602-1671

    ERIC Educational Resources Information Center

    Fares, Laila

    2012-01-01

    The study constituting the object of this research on one of the best French poets of the 17th century, yet one of the least known, Pierre Le Moyne, aims at restoring this great French poet in his right place, preparing and clearing the way in order to allow further research and stimulate future interest in his works. Pierre Le Moyne is not only…

  15. LeCPK1, a Calcium-Dependent Protein Kinase from Tomato. Plasma Membrane Targeting and Biochemical Characterization1

    PubMed Central

    Rutschmann, Frank; Stalder, Urs; Piotrowski, Markus; Oecking, Claudia; Schaller, Andreas

    2002-01-01

    The cDNA of LeCPK1, a calcium-dependent protein kinase, was cloned from tomato (Lycopersicon esculentum Mill.). LeCPK1 was expressed in Escherichia coli and purified from bacterial extracts. The recombinant protein was shown to be a functional protein kinase using a synthetic peptide as the substrate (syntide-2, Km = 85 μm). Autophosphorylation of LeCPK1 was observed on threonine and serine residues, one of which was identified as serine-439. Kinase activity was shown to be Ca2+ dependent and required the C-terminal, calmodulin-like domain of LeCPK1. Two classes of high- and low-affinity Ca2+-binding sites were observed, exhibiting dissociation constants of 0.6 and 55 μm, respectively. LeCPK1 was found to phosphorylate the regulatory C-terminal domain of the plasma membrane H+-ATPase in vitro. A potential role in the regulation of proton pump activity is corroborated by the apparent colocalization of the plasma membrane H+-ATPase and LeCPK1 in vivo. Upon transient expression in suspension-cultured cells, a C-terminal fusion of LeCPK1 with the green fluorescent protein was targeted to the plasma membrane. Myristoylation of the LeCPK1 N terminus was found to be required for plasma membrane targeting. PMID:12011347

  16. Experiment and numerical simulation on cross-die forming of SUS304 metastable austenitic stainless using a modified Johnson-Cook model

    NASA Astrophysics Data System (ADS)

    Li, Xifeng; Ding, Wei; Ye, Liyan; Chen, Jun

    2013-12-01

    True stress-strain curves of SUS304 metastable austenitic stainless steel at various strain rates were fitted by a modified Johnson-Cook material model. The effect of blank-holder force on Cross-die forming of SUS304 stainless steel was studied. The forming process was also simulated by the software Marc based on this model. Major strain distribution, thickness distribution and load-displacement were compared between experiment and simulation. The results indicated the modified Johnson-Cook model could well predict the deformation behavior of SUS304 stainless steel. The martensitie volume fraction at different positions of the formed part was in good agreement with what can be expected.

  17. Retour vers le futur: l'expérience des patients et le lien avec la qualité, la sécurité et le rendement financier.

    PubMed

    Cochrane, Bonnie S; Hagins, Mitch; King, John A; Picciano, Gino; McCafferty, Maureen M; Nelson, Brian

    2015-11-01

    Au Canada, l'amélioration de l'expérience des patients est devenue une priorité des politiques de santé. Le perfectionnement et la normalisation des outils et systèmes pour surveiller les mesures de l'expérience des patients augmentent, tandis que la tendance vers une plus grande reddition de compte sur des améliorations durables et abordables se confirme. Pour de nombreux professionnels de la santé, ce phénomène fait foi d'un intérêt renouvelé pour les besoins et priorités fondamentaux des patients, après des décennies où les changements structurels et technologiques ont dominé les programmes de santé. Pour les leaders en santé canadiens, l'amélioration de l'expérience des patients comporte actuellement de grands défis et de belles possibilités. À cet égard, l'expérience des organisations partenaires du groupe Studer au Canada est à la fois pertinente et instructive. Ces organisations ont adopté un modèle, du nom de Evidence-Based Leadership (EBL, ou leadership fondé sur des données probantes), qui favorise et soutient l'harmonisation de l'ensemble des activités et des comportements, conformément à des objectifs organisationnels précis, y compris des améliorations mesurables de l'expérience des patients. Le présent article expose des études de cas d'organisations qui ont adopté l'EBL. Ces organisations ont réalisé des progrès rapides en matière d'indicateurs de l'expérience des patients, ainsi que dans des secteurs essentiels comme les résultats cliniques, la sécurité et le rendement financier. Les données émergentes sur les facteurs et processus qui sous-tendent ces améliorations sont également abordées.

  18. Students' and Teachers' Misapplication of Le Chatelier's Principle: Implications for the Teaching of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Quilez-Pardo, Juan; Solaz-Portoles, Joan Josep

    1995-01-01

    Study of strategies and procedures of 170 students and 40 teachers when solving chemical equilibrium problems found misconceptions emerging through: misapplication of Le Chatelier's Principle, use of rote-learning recall, incorrect control of variables, limited use of chemical equilibrium law, lack of mastery of chemical equilibrium principles,…

  19. Le Chatelier's Principle: The Effect of Temperature on the Solubility of Solids in Liquids.

    ERIC Educational Resources Information Center

    Brice, L. K.

    1983-01-01

    Provides a rigorous but straightforward thermodynamic treatment of the temperature dependence of the solubility of solids in liquids that is suitable for presentation to undergraduates, suggesting how to approach the qualitative aspects of the subject for freshmen. Considers unsolvated/solvated solutes and Le Chatelier's principle. (JN)

  20. LE[superscript 3]AD Academy Builds Professionalism in Vocational Students

    ERIC Educational Resources Information Center

    Hall, Candace

    2012-01-01

    Principal David Wheeler of Southeastern Regional Vocational-Technical High School founded LE[superscript 3]AD Academy--an innovative program that gives students the opportunity to build and run their own town in teams and with guidance from teachers. The program started in the spring of 2011, and it is innovative in many ways. The students' main…

  1. From Interactive Open Learner Modelling to Intelligent Mentoring: STyLE-OLM and Beyond

    ERIC Educational Resources Information Center

    Dimitrova, Vania; Brna, Paul

    2016-01-01

    STyLE-OLM (Dimitrova 2003 "International Journal of Artificial Intelligence in Education," 13, 35-78) presented a framework for interactive open learner modelling which entails the development of the means by which learners can "inspect," "discuss" and "alter" the learner model that has been jointly…

  2. Une fistule recto-vaginale rentrant dans le cadre d'un syndrome de Currarino

    PubMed Central

    Idrissi, Mounia Lakhdar; Babakhoya, Abdeladim; Bouabdellah, Youssef; Hida, Mostapha

    2011-01-01

    Le syndrome de Currarino (SC) est défini par une triade rassemblant une malformation ano-rectale, une agénésie sacrée et une tumeur pré-sacrée. Nous rapportons le cas d'une fille de 4 ans et demi ayant été admise en consultation de gastro-entérologie pédiatrique pour constipation avec issue de selle à travers un orifice vulvaire. La radiographie du rachis avait montré une agénésie sacrée. Le fistulo-scanner a mis en évidence une fistule recto-vaginale et l'IRM pelvienne a confirmé l'agénésie sacrée et a retrouvé une méningocèle antérieure. La découverte d'une malformation ano-rectale doit faire chercher une autre anomalie de la triade de Currarino. Cette affection, rare, nécessite une prise en charge médico-chirurgicale assez complexe. PMID:22384297

  3. [Roentgendiagnostic of the peritoneovenous drainage after Le Veen for ascitestreatment (author's transl)].

    PubMed

    Vogel, H; Dahm, K

    1978-12-01

    The peritoneovenous drainage after Le Veen offers a possibility of the ascitestreatment. The roentgenexamination showed wrong positions of the katheter as the most frequent cause of dysfunctions. They were regularly combined with venous obstructions. The intraoperativ x-ray diagnostic can fascilate the shunt application and may help to spare a second operation.

  4. Tested Demonstrations: Thermodynamic Changes, Kinetics, Equilibrium, and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for demonstrating thermodynamic changes, kinetics and reaction mechanisms, equilibrium, and LeChatelier's principle are presented. The only materials needed for these demonstrations are beakers, water, assorted wooden blocks of varying thickness, assorted rubber tubing, and a sponge. The concepts illustrated in each demonstration are…

  5. Heading the ball: a case of a Le Fort II fracture in a football match.

    PubMed

    Akoglu, Ebru; Onur, Ozge; Denizbasi, Arzu; Kosargelir, Mehmet; Akoglu, Haldun; Ibrahim, Abdullah

    2011-03-15

    Facial injuries can impair a patient's ability to eat, speak and interact with others. Severe injuries occur as a result of interpersonal or domestic violence, or in motor vehicle collisions, including those involving motorcycles and all-terrain vehicles. The authors present a case of LeFort II fracture caused by a collision of opponents while heading the ball in a football match.

  6. Le chondrosarcome naso-sinusien: à propos de deux cas et revue de la literature

    PubMed Central

    Touati, Mohamed Mliha; Chihani, Mehdi; Darouassi, Youssef; Lakouichmi, Mohammed; Tourabi, Khalid; Bouaity, Brahim; Ammar, Haddou

    2014-01-01

    Le chondrosarcome est une tumeur maligne très destructrice d'origine cartilagineuse, osseuse et mesnchymateuse. La localisation au niveau de la tête et cou est rare et le siège naso sinusien est encore plus rare. Nous rapportons deux observations de chondrosarcome du sinus maxillaire droit et sphéno ethmoïdale. Le but de notre travail est de montrer à travers ces deux cas cliniques, l'intérêt de la tomodensitométrie et de la résonance magnétique dans la présemption diagnostique en corrélation avec la clinique et l'endoscopie,de discuter le choix de la voix et la technique d'abord chirurgical et la surveillance post opératoire. A travers ces deux observations nous soulignerons les difficultés que pose cette tumeur à l'anatomopathologiste pour différencier entre chondrome et chondrosarcome. PMID:25810801

  7. The clinical and experimental studies of ChanLe Chongji for reducing bleeding after abortion.

    PubMed

    Zhao, R; Ding, Y; Hu, Y

    1999-01-01

    This report presents the results of the clinical and experimental studies conducted to determine the effectiveness of ChanLe Chongji, a Chinese medicine. ChanLe Chongji is believed to promote uterine contraction, stop bleeding, resist bacteria and diminish inflammation. The clinical study was done on 100 women with the following characteristics: under 35 years old; in good health; no contraindication to mifepristone and prostaglandin; normal menses for the past 3 months; not more than 49 days after amenorrhea; intrauterine pregnancy diagnosed by urine human chorionic gonadotropin or ultrasonography. These women were divided into two groups (treated group and control group). An experimental portion of the study included kunming mice weighing 25-30 g and on Wistar rats weighing 180-230 g. The results of the clinical study revealed that the mean bleeding period in the treated group was 8.4 days, while it was 13.3 days in the control group. The mean complete abortion rate was 95% in the treated group and 88% in the control group. A pharmacodynamic test was conducted during the animal experimental portion to comprehend the mechanism of hemostasis. It showed that ChanLe Chongji could increase uterine contraction and stop bleeding; maximal dosage also demonstrated that ChanLe Chongji was safe in clinical use.

  8. 5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, NORTHEAST AND SOUTHEAST PARLORS, ORIGINAL MANTEL (LEFT - RADIATOR COVERED). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  9. Erratum dans le numéro de mai-juin 1988

    NASA Astrophysics Data System (ADS)

    Erratum dans le numéro de mai-juin 1988: Dans l'article sur les étoiles à baryum: p. 74, 2e colonne (après la première formule), il faut lire «A est la masse atomique» au lieu de «nombre atomique»

  10. Reconnaissance Invariante des Formes avec le Filtre de Fourier-Mellin et un Reseau Neuronique

    NASA Astrophysics Data System (ADS)

    Lejeune, Claude

    Le filtre de Fourier-Mellin est applique a un ensemble d'objets pour generer des vecteurs invariants sous translation, rotation et changement d'echelle. C'est la premiere methode permettant d'obtenir ces trois invariants simultanement. Le calcul des vecteurs invariants est fait numeriquement et optiquement. Les vecteurs ainsi obtenus sont utilises comme entrees dans un reseau neuronique backpropagation pour faire la classification des prototypes qui lui sont presentes. Les dimensions des vecteurs invariants sont tres petites par rapport aux objets d'entree et permettent d'utiliser un reseau possedant un nombre restreint de connexions. Il devient possible d'entrai ner le reseau dans des temps relativement courts sur un ordinateur du type PC. Une fois le reseau entrai ne, nous lui presentons des vecteurs invariants provenant d'objets se retrouvant dans l'ensemble d'entrai nement mais ayant subi des rotations et des changements d'echelle. Ce nouveau groupe represente l'ensemble de rappel. La performance de la methode est tres bonne avec des taux de succes superieurs a 85%.

  11. The Potassium-Argon Laser Experiment (KarLE): In Situ Geochronology for Mars and Beyond

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2014-01-01

    The search for life in the solar system depends upon discovering the right moments in planetary evolution: when habitable environments existed, when they declined, and when geologic processes operated to preserve traces of life after death. However, an incomplete knowledge of absolute Martian geochronology limits our ability to understand the timing of Martian evolutionary milestones, major climate changes, and stratigraphic epochs [1, 2]. Absolute dating relates these habitability markers to planetarywide geologic, atmospheric, and climate history places, and ties their occurrence to the history of the solar system, especially the Earth-Moon system and the timescale of evolution of life on Earth. KArLE is being developed to anchor the relative timeline of geological events to an absolute chronology that puts Mars into a wider solar system context. KArLE makes its measurements on rock samples that can be obtained by landers or rovers and inserted into a small, mechanically simple chamber. KArLE interrogates the samples using laser-induced breakdown spectrocopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of mission payloads to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  12. Developement of the Potassium-Argon Laser Experiment (KArLE) for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Thus far, radiometric geochronology of planetary samples has only been accomplishable in terrestrial laboratories on samples from dedicated sample return missions and meteorites. In situ instruments to measure rock ages have been proposed, but none have yet reached TRL 6, because isotopic measurements with sufficient resolution are challenging. We have begun work under the NASA Planetary Instrument Definition and Development Program (PIDDP) to develop the Potassium (K) - Argon Laser Experiment (KArLE), a novel combination of several flight-proven components that will enable accurate KAr isochron dating of planetary rocks. KArLE will ablate a rock sample, measure the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by measuring the volume of the abated pit using a optical methods such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to 100 Myr, sufficient to address a wide range of geochronology problems in planetary science. Additional benefits derive from the fact that each KArLE component achieves analyses common to most planetary surface missions.

  13. Developing Communication Skills in Deaf Primary School Pupils: Introducing and Evaluating the SmiLE Approach

    ERIC Educational Resources Information Center

    Alton, Sherryn; Herman, Rosalind; Pring, Tim

    2011-01-01

    Many profoundly deaf signers have difficulty communicating with hearing people. This article describes a therapy called "Strategies and Measurable Interaction in Live English" (smiLE; Schamroth and Threadgill, 2007a), an approach used to teach deaf children skills to become successful communicators in real-life situations. This study…

  14. Habitat and nesting of Le Conte's Sparrows in the northern tallgrass prairie

    USGS Publications Warehouse

    Winter, M.; Shaffer, J.A.; Johnson, D.H.; Donovan, T.M.; Svedarsky, W.D.; Jones, P.W.; Euliss, B.R.

    2005-01-01

    Little is known about the breeding biology of the Le Conte's Sparrow (Ammodramus leconteii), probably because of its secretive nature. We provide new information on several aspects of Le Conte's Sparrow breeding biology, including rates of nest parasitism by Brown-headed Cowbirds (Molothrus ater) and potential factors affecting breeding densities and nesting success of the species. Our study was conducted in the tallgrass prairie of northwestern Minnesota and southeastern North Dakota during 1998-2002. Breeding densities varied among years, but this variation was not clearly linked to climatic patterns. Vegetation had some influence on densities of Le Conte's Sparrows; densities were highest in grasslands with moderate amounts of bare ground. Prairie patch size and the percentage of shrubs and trees in the landscape had no recognizable influence on density. Nesting success was highly variable among sites and years and increased slightly with distance from trees. Rates of nest parasitism were low (1 of 50 nests parasitized), and clutch sizes were similar to those of other studies of Le Conte's Sparrows.

  15. Tested Demonstrations: Thermodynamic Changes, Kinetics, Equilibrium, and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for demonstrating thermodynamic changes, kinetics and reaction mechanisms, equilibrium, and LeChatelier's principle are presented. The only materials needed for these demonstrations are beakers, water, assorted wooden blocks of varying thickness, assorted rubber tubing, and a sponge. The concepts illustrated in each demonstration are…

  16. Coût clinique des retards dans le changement de traitement

    PubMed Central

    Walmsley, Sharon

    2007-01-01

    La prise en charge des patients séropositifs pour le VIH ayant déjà reçu un traitement continue de s’améliorer et d’évoluer. Les nouvelles lignes directrices semblent indiquer que l’objectif du traitement devrait être une suppression virologique maximale. La meilleure façon d’y parvenir consiste à utiliser une combinaison d’agents auxquels le virus sera le plus vraisemblablement sensible et, si possible, des agents appartenant à une nouvelle classe thérapeutique. Les cas discutés démontrent comment l’utilisation d’un schéma thérapeutique puissant à titre de traitement de sauvetage peut avoir de bons résultats virologiques, immunologiques et cliniques. Toutefois, si le traitement de sauvetage retenu n’est pas assez puissant pour atteindre ces objectifs, la durabilité de la réponse est limitée. Ce qu’il faut retenir ici, c’est que ces stratégies devraient reposer sur la puissance du schéma thérapeutique et qu’il ne faut pas retarder l’instauration des agents en cas d’échec d’une stratégie.

  17. Le monde des affaires (The Business World). Teacher's Guide [and] Student's Book.

    ERIC Educational Resources Information Center

    Laing, Martha; Ullmann, Rebecca

    The two components of this publication are the student's book and the teacher's guide to the module, "The Business World" or "Le monde des affaires," which would be suitable for use in an advanced French course or in a class of business French. The teacher's book in French and English has four parts: (1) an explanation of the…

  18. Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening.

    PubMed

    Chen, Weiwei; Kong, Junhua; Lai, Tongfei; Manning, Kenneth; Wu, Chaoqun; Wang, Ying; Qin, Cheng; Li, Bin; Yu, Zhiming; Zhang, Xian; He, Meiling; Zhang, Pengcheng; Gu, Mei; Yang, Xin; Mahammed, Atef; Li, Chunyang; Osman, Toba; Shi, Nongnong; Wang, Huizhong; Jackson, Stephen; Liu, Yule; Gallusci, Philippe; Hong, Yiguo

    2015-01-19

    In plants, microRNAs (miRNAs) play essential roles in growth, development, yield, stress response and interactions with pathogens. However no miRNA has been experimentally documented to be functionally involved in fruit ripening although many miRNAs have been profiled in fruits. Here we show that SlymiR157 and SlymiR156 differentially modulate ripening and softening in tomato (Solanum lycopersicum). SlymiR157 is expressed and developmentally regulated in normal tomato fruits and in those of the Colourless non-ripening (Cnr) epimutant. It regulates expression of the key ripening gene LeSPL-CNR in a likely dose-dependent manner through miRNA-induced mRNA degradation and translation repression. Viral delivery of either pre-SlymiR157 or mature SlymiR157 results in delayed ripening. Furthermore, qRT-PCR profiling of key ripening regulatory genes indicates that the SlymiR157-target LeSPL-CNR may affect expression of LeMADS-RIN, LeHB1, SlAP2a and SlTAGL1. However SlymiR156 does not affect the onset of ripening, but it impacts fruit softening after the red ripe stage. Our findings reveal that working together with a ripening network of transcription factors, SlymiR157 and SlymiR156 form a critical additional layer of regulatory control over the fruit ripening process in tomato.

  19. Molecular and cellular characterization of the tomato pollen profilin, LePro1

    USDA-ARS?s Scientific Manuscript database

    Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton in all eukaryotic cells. We previously cloned a profilin gene, designated as LePro1 from tomato pollen. To investigate its biological role, in the present study, We investigated the tem...

  20. 8. VIEW FORWARD IN CREW'S QUARTERS (FOC'S'LE) SHOWING DOUBLE TIER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW FORWARD IN CREW'S QUARTERS (FOC'S'LE) SHOWING DOUBLE TIER OF BUNKS IN THE EVELINA M. GOULART. KINGPOST IS AT CENTER OF PHOTOGRAPH WITH FORE PEAK IN BACKGROUND. A FOLDING MESS TABLE IS AT LOWER LEFT OF PHOTOGRAPH. NOTE BENCH SEAT BELOW LOWEST TIER OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  1. 10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE EVELINA M. GOULART. OBJECT IN THE FOREGROUND IS A FOLDING MESS TABLE LOCATED BETWEEN THE TIERS OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  2. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  3. Le syndrome de Stewart-Treves compliquant un lymphœdème chronique idiopathique

    PubMed Central

    Safini, Fatima; Naim, Asmaa; Bouchbika, Zineb; Benchakroun, Nadia; Jouhadi, Hassan; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2014-01-01

    Le syndrome de Stewart-Treves (SST) est une entité rare, correspondant à un angiosarcome cutané compliquant un lymphoedème chronique. Il est de mauvais pronostic. Stewart et Treves ont rapportés en 1948, les premiers cas d'angiosarcome secondaire à un traitement du cancer du sein. Ce terme s'est généralisé pour regrouper l'ensemble des cas de lymphangiosarcome sur lymphoedème d'origine congénital héréditaire ou non héréditaire, post-traumatique ou post-infectieux. Le SST sur un lymphoedème idiopathique reste exceptionnel. Nous rapportons le cas rare d'une patiente présentant un lymphoedème chronique primitif idiopathique des quatre membres évoluant depuis l'adolescence et qui a développé un SST du membre supérieur droit. Elle a subi une amputation à mi- bras vu le caractère très évolué de la tumeur PMID:25883738

  4. Macrosphelide B suppressed metastasis through inhibition of adhesion of sLe(x)/E-selectin molecules.

    PubMed

    Fukami, Akiko; Iijima, Kousuke; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi

    2002-03-08

    Macrosphelide B (MSB), a 16-membered macrolide from Microsphaeropsis sp. FO-5050, inhibits adhesion of sialyl Lewis(x) (sLe(x))-expressing HL-60 cells to LPS-activated (E-selectin-expressing) human umbilical vein endothelial cells (HUVECs) in vitro. This study examines MSB effects on metastasis of B16/BL6 mouse melanoma cells (B16/BL6 cells) and L5178Y-ML mouse lymphoma cells in vivo and analyzes the MSB antimetastatic activity mechanism. When administered MSB at 20 mg/kg/day, lung metastatic nodules of B16/BL6 cells were significantly decreased (T/C = 45%). However, no inhibition of metastasis of L5178Y-ML cells to the spleen and liver was observed. Flow cytometry analysis showed that B16/BL6 cells expressed high levels of sLe(x) antigen, whereas expression on L5178Y-ML cells was low. Under in vitro conditions, B16/BL6 cells demonstrated a greater degree of adhesion to LPS-activated HUVECs than L5178Y-ML cells, but adhesion was significantly inhibited by MSB and sLe(x) antibody. Combined therapy of MSB and cisplatin (CDDP) induced remarkable lung metastasis inhibition without adverse effects of CDDP to the host. All these findings suggest that MSB suppresses lung metastasis of B16/BL6 cells by inhibiting cell adhesion to endothelial cells through the sLe(x) molecule.

  5. The Ammonia Synthesis Reaction: An Exception to the Le Chatelier Principle and Effects of Nonideality

    ERIC Educational Resources Information Center

    Uline, Mark J.; Corti, David S.

    2006-01-01

    Le Chatelier's principle states that the further addition of a particular component will cause the reaction to shift in the direction that reduces the total number of moles of the system. However, the addition of one reactant [N[subscript 2

  6. List processing software for the LeCroy 1821 Segment Manager Interface

    SciTech Connect

    Dorries, T.; Moore, C.; Pordes, R.

    1987-05-01

    Many experiments at Fermilab now include some FASTBUS electronics in their data readout. The software reported in this paper provides general support for the LeCroy 1821 interface. The list processing device drivers allow FASTBUS data to be read out efficiently into the Fermilab Computing Department supported data acquisition systems.

  7. Through Ecofeminist Eyes: Le Guin's "The Ones Who Walk Away from Omelas"

    ERIC Educational Resources Information Center

    Bennett, Barbara

    2005-01-01

    Barbara Bennett explains the tenets behind ecofeminism and why it is a useful and appropriate method of literary analysis for today's world. By applying the theory to Le Guin's story, she helps her students relate the issues of ecofeminism to their American lifestyle.

  8. Through Ecofeminist Eyes: Le Guin's "The Ones Who Walk Away from Omelas"

    ERIC Educational Resources Information Center

    Bennett, Barbara

    2005-01-01

    Barbara Bennett explains the tenets behind ecofeminism and why it is a useful and appropriate method of literary analysis for today's world. By applying the theory to Le Guin's story, she helps her students relate the issues of ecofeminism to their American lifestyle.

  9. Taking Your Talents to Business Communications: Analyzing Effective Communication through LeBron James's Career Moves

    ERIC Educational Resources Information Center

    Manisaligil, Alperen; Bilimoria, Diana

    2016-01-01

    We describe an in-class activity that helps students improve their skills in media selection and use to reinforce effective communication. The activity builds on media richness and channel expansion theories through an examination of the media selection and use of NBA athlete LeBron James and Cleveland Cavaliers majority owner Dan Gilbert during…

  10. Red Turpentine Beetle, Dendroctonus valens LeConte (Coleoptera: Scolytidae), Response to Host Semiochemicals in China

    Treesearch

    Jianghua Sun; Zhengwan Miao; Zhen Zhang; Zhongning Zhan; Nancy Gillette

    2004-01-01

    The response of the introduced red turpentine beetle, Dendroctonus valens LeConte, to host semiochemicals in Shanxi Province, China, was distinctly different from that reported in previous studies conducted in the western part of the native range of D. valens in the central Sierra Nevada, CA. This Þnding suggests either that...

  11. Students' and Teachers' Misapplication of Le Chatelier's Principle: Implications for the Teaching of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Quilez-Pardo, Juan; Solaz-Portoles, Joan Josep

    1995-01-01

    Study of strategies and procedures of 170 students and 40 teachers when solving chemical equilibrium problems found misconceptions emerging through: misapplication of Le Chatelier's Principle, use of rote-learning recall, incorrect control of variables, limited use of chemical equilibrium law, lack of mastery of chemical equilibrium principles,…

  12. The Adverse Effects of Le Chatelier's Principle on Teacher Understanding of Chemical Equilibrium

    ERIC Educational Resources Information Center

    Cheung, Derek

    2009-01-01

    Although the scientific inadequacy of Le Chatelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has…

  13. "Ambivalence to Technology in Jeunet's" Le Fabuleux Destin d'Amelie Poulain

    ERIC Educational Resources Information Center

    Moore, Rick Clifton

    2006-01-01

    Although at one level Jean-Pierre Jeunets "Le Fabuleux Destin d'Amelie Poulain" is a sweet, attractive film about a young Parisian doing good deeds, it also offers a compelling analysis of the role of technology in our modern lives. The film paints a world where machines and a mechanistic worldview are appealing because humans have a desire to…

  14. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  15. Geomorphic evolution of the Le Sueur River, Minnesota, USA, and implications for current sediment loading

    USGS Publications Warehouse

    Gran, K.B.; Belmont, P.; Day, S.S.; Jennings, C.; Johnson, Aaron H.; Perg, L.; Wilcock, P.R.

    2009-01-01

    There is clear evidence that the Minnesota River is the major sediment source for Lake Pepin and that the Le Sueur River is a major source to the Minnesota River. Turbidity levels are high enough to require management actions. We take advantage of the well-constrained Holocene history of the Le Sueur basin and use a combination of remote sensing, fi eld, and stream gauge observations to constrain the contributions of different sediment sources to the Le Sueur River. Understanding the type, location, and magnitude of sediment sources is essential for unraveling the Holocene development of the basin as well as for guiding management decisions about investments to reduce sediment loads. Rapid base-level fall at the outlet of the Le Sueur River 11,500 yr B.P. triggered up to 70 m of channel incision at the mouth. Slope-area analyses of river longitudinal profi les show that knickpoints have migrated 30-35 km upstream on all three major branches of the river, eroding 1.2-2.6 ?? 109 Mg of sediment from the lower valleys in the process. The knick zones separate the basin into an upper watershed, receiving sediment primarily from uplands and streambanks, and a lower, incised zone, which receives additional sediment from high bluffs and ravines. Stream gauges installed above and below knick zones show dramatic increases in sediment loading above that expected from increases in drainage area, indicating substantial inputs from bluffs and ravines.

  16. Life History and Biology of Ips latidens (LeConte) (Coleoptera: Scolytidae)\\t

    Treesearch

    D.R. Miller; J.H. Borden

    1985-01-01

    The life history and biology of Ips latidens (LeConte) were investigated using bark-sandwich and whole-log rearing methods. In contrast with other Ips spp., some females initiated galleries under conditions of female-biased sex ratios, and sometimes 2 or more males were present in a gallery. In general, however, I....

  17. Taking Your Talents to Business Communications: Analyzing Effective Communication through LeBron James's Career Moves

    ERIC Educational Resources Information Center

    Manisaligil, Alperen; Bilimoria, Diana

    2016-01-01

    We describe an in-class activity that helps students improve their skills in media selection and use to reinforce effective communication. The activity builds on media richness and channel expansion theories through an examination of the media selection and use of NBA athlete LeBron James and Cleveland Cavaliers majority owner Dan Gilbert during…

  18. Developing Communication Skills in Deaf Primary School Pupils: Introducing and Evaluating the SmiLE Approach

    ERIC Educational Resources Information Center

    Alton, Sherryn; Herman, Rosalind; Pring, Tim

    2011-01-01

    Many profoundly deaf signers have difficulty communicating with hearing people. This article describes a therapy called "Strategies and Measurable Interaction in Live English" (smiLE; Schamroth and Threadgill, 2007a), an approach used to teach deaf children skills to become successful communicators in real-life situations. This study…

  19. 9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP OF SMALL FRONT FIREPLACE, SOUTHWEST ROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  20. 11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ROOM SHOWING ORIGINAL CORNER FIREPLACE, OPENING BEHIND BAR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  1. 8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 REEDING DETAIL OF MANTEL IN NORTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  2. 13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 STAIR DETAIL, SECOND FLOOR LEVEL (INSPECTION OF STAIR REVEALS PRESENCE OF A STRING OPPOSITE BANNISTER ORIGINALLY). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  3. 6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHWEST ROOM SHOWING COOK FIREPLACE, ORIGINAL MANTEL, CRANE AND OPENING FOR BAKE OVEN. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  4. 12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP DETAIL OF CORNER FIREPLACE. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  5. Selected data for stream subbasins in the Le Sueur River basin, south-central Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.; Payne, G.A.

    1990-01-01

    This report presents selected data that describe the characteristics of stream basins upstream from selected points on streams in the Le Sueur River basin. The points on the streams include outlets of subbasins of about five square miles, sewage treatment plant outlets, and U.S. Geological Survey streamflow-gaging stations in the basin.

  6. "Ambivalence to Technology in Jeunet's" Le Fabuleux Destin d'Amelie Poulain

    ERIC Educational Resources Information Center

    Moore, Rick Clifton

    2006-01-01

    Although at one level Jean-Pierre Jeunets "Le Fabuleux Destin d'Amelie Poulain" is a sweet, attractive film about a young Parisian doing good deeds, it also offers a compelling analysis of the role of technology in our modern lives. The film paints a world where machines and a mechanistic worldview are appealing because humans have a desire to…

  7. LE[superscript 3]AD Academy Builds Professionalism in Vocational Students

    ERIC Educational Resources Information Center

    Hall, Candace

    2012-01-01

    Principal David Wheeler of Southeastern Regional Vocational-Technical High School founded LE[superscript 3]AD Academy--an innovative program that gives students the opportunity to build and run their own town in teams and with guidance from teachers. The program started in the spring of 2011, and it is innovative in many ways. The students' main…

  8. From Interactive Open Learner Modelling to Intelligent Mentoring: STyLE-OLM and Beyond

    ERIC Educational Resources Information Center

    Dimitrova, Vania; Brna, Paul

    2016-01-01

    STyLE-OLM (Dimitrova 2003 "International Journal of Artificial Intelligence in Education," 13, 35-78) presented a framework for interactive open learner modelling which entails the development of the means by which learners can "inspect," "discuss" and "alter" the learner model that has been jointly…

  9. The Ammonia Synthesis Reaction: An Exception to the Le Chatelier Principle and Effects of Nonideality

    ERIC Educational Resources Information Center

    Uline, Mark J.; Corti, David S.

    2006-01-01

    Le Chatelier's principle states that the further addition of a particular component will cause the reaction to shift in the direction that reduces the total number of moles of the system. However, the addition of one reactant [N[subscript 2

  10. Borel-Le Roy summability of the high temperature expansion for classical continuous systems

    NASA Astrophysics Data System (ADS)

    Maioli, Marco

    1985-06-01

    For classical gases with suitable pair interactions such that Φ( r)˜(ln r -1) p as r→0 ( p∈ℕ), the Taylor expansion in β of the correlation functions and the pressure are summable at β=0 by the Borel-Le Roy method of order p+1.

  11. The Adverse Effects of Le Chatelier's Principle on Teacher Understanding of Chemical Equilibrium

    ERIC Educational Resources Information Center

    Cheung, Derek

    2009-01-01

    Although the scientific inadequacy of Le Chatelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has…

  12. Spectrofluorimetric determination of dopamine receptor antagonist LE 300 in mice plasma.

    PubMed

    Hefnawy, Mohamed; Mohamed, Mostafa; Abunassif, Mohamed; Alanazi, Amer; Al-Majed, Abdulrahman; Jochen, Lehmann; Mostafa, Gamal Abdel-Hafiz

    2016-02-01

    A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of a novel type of dopamine receptor antagonist LE300 in mouse plasma. The method is based on measuring the native fluorescence of LE-300 in methanol at 343 nm after excitation at 280 nm. The fluorescence concentration plot was rectilinear over the range of 3.5-100 ng/mL with a lower detection limit of 1.0 ng/mL and quantification limit of 3.5 ng/mL. The method was statistically validated for linearity, accuracy, precision and selectivity according to the International Conference on Harmonization guidelines. The accuracy and precision results was expressed as % recovery and relative standard deviation (RSD). The accuracy for LE-300 was in the range 95.5-103.6% and RSD values were in the range of 0.21-1.55% of the theoretical value. The method was successfully applied to the analysis of LE-300 in mice plasma. The results were compared statistically with those obtained by the reported method and were found to be in good agreement, which could be applied in a pharmacokinetic study.

  13. Immobilized Lotus tetragonolobus agglutinin binds oligosaccharides containing the Le(x) determinant.

    PubMed

    Yan, L; Wilkins, P P; Alvarez-Manilla, G; Do, S I; Smith, D F; Cummings, R D

    1997-01-01

    A defined set of oligosaccharides and glycopeptides containing alpha-linked fucose were used to examine the specificity of the immobilized fucose-binding lectin Lotus tetragonolobus agglutinin (LTA1), also known as lotus lectin. Glycans containing the Lewis x determinant (Le(x)) Gal beta 1-4[Fuc alpha 1-3]GlcNAc beta 1-3-R were significantly retarded in elution from high density LTA-Emphaze columns. The lectin also bound the fucosylated lacdiNAc trisaccharide GalNAc beta 1-4[Fuc alpha 1-3]GlcNAc. The lectin did not bind glycans containing either sialylLe(x) or VIM-2 determinants, nor did it bind the isomeric Le(x), Gal beta 1-3[Fuc alpha 1-4]GlcNAc-R. Although 2'-fucosyllactose Fuc alpha 1-2Gal beta 1-4Glc) was retarded in elution from the columns, larger glycans containing the H-antigen Fuc alpha 1-2Gal beta 1-3(4)GlcNAc-R interacted poorly with immobilized LTA. Our results demonstrate that immobilized LTA is effective in isolating glycans containing the Le(x) antigen and is useful in analyzing specific fucosylation of glycoconjugates.

  14. Standardissimo. Les limitations théoriques du Modèle Standard. Quelles réponses y apporter?

    NASA Astrophysics Data System (ADS)

    Renard, F. M.

    Nous présentons I 'état du Modèle Standard des interactions fortes, faibles et électromagnétiques. Après une description rapide de ses 3 secteurs, secteur de jauge (radiation), secteur fermionique (matière) et secteur scalaire (génération des masses), nous insistons sur le grand nombre de paramètres libres et sur les choix arbitraires qu'il a fallu faire dans l'élaboration du modèle. Nous faisons ressortir les problèmes techniques non résolus et nous dressons la liste des questions fondamentales restées sans réponses. Nous passons ensuite en revue les idées et méthodes proposées pour répondre à ces questions. Elles utilisent essentiellement 3 voies différentes. La première consiste à requérir plus de symétrie (extension du modèle, symétrie Gauche-Droite, Grandes Unifications, Supersymétrie,...). La seconde contient les diverses alternatives au Modèle Standard impliquant des modifications dans certains secteurs (par exemple le secteur scalaire avec le modèle de la Technicouleur) ou de façon plus violente l'hypothèse d'une sous-structure des leptons, des quarks et des bosons W et Z eux-mêmes. Une dernière voie cherche à justifier les particularités du Modèle Standard et relier ses paramètres libres en se basant sur des principes de cohérence interne du modèle. Les conséquences observables de ces diverses approches sont dans chaque cas mentionnées.

  15. Le cavernome porte chez l'enfant: a propos de 11 cas

    PubMed Central

    Ilham, Tadmori; Mounia, Lakhdar Idrissi; Moustapha, Hida

    2014-01-01

    Le cavernome portal est la conséquence d'une occlusion chronique, du système porte extra-hépatique formé d'un réseau de veines dont le calibre est augmenté et au sein desquelles chemine un sang portal hépatopéte. Chez l'enfant, est une cause majeure d'hypertension portale dite «pré ou infra-hépatique» ou encore «extra-hépatique». Onze cas de cavernome porte parmi 78 cas d'hypertension portale ont été colligés au service sur une période allant du Janvier 2003 au Septembre 2012. L’âge de nos patients variait entre 2 et 15 ans et le sexe ratio est de 1,75. Tous nos patients étaient admis au stade d'hypertension portale avec la splénomégalie SMG (100% des cas); hémorragies digestives (63%); ascite (36%); la circulation veineuse collatérale CVC et l'hépatomégalie HMG (27%). L'exploration endoscopique a objectivé la présence de varices ‘sophagiennes dans tous les cas avec une gastropathie hypertensive dans 27% et des varices ectopiques chez 36%. Les perturbations biologiques étaient dominées par la pancytopénie. Le bilan de thrombophilie était demandé pour tous les malades mais réalisé mais n'est réalisé que chez trois revenus normaux chez deux et a objectivé une baisse de protéine S chez le troisième. L’échographie abdominale était le moyen de diagnostic positif et l’écho-doppler a confirmé l'HTP chez tous nos patients. Aucun de nos malades n'a pu être opéré pour le moment. La ligature a été réalisée chez 54,5%. Dix patients ont nécessité une transfusion sanguine. L’évolution globale de nos patients est favorable. La durée moyenne d’évolution du cavernome porte chez nos patients est de quatre ans. PMID:25870732

  16. Le dermatofibrosarcome de Darier et Ferrand: à propos de 27 cas et revue de la literature

    PubMed Central

    Hammas, Nawal; Badioui, Ikram; Znati, Kaoutar; Benlemlih, Amal; Chbani, Laila; El Fatemi, Hind; Harmouch, Taoufiq; Bouyahyaoui, Youssef; Boutayeb, Faouzi; Mrini, Abdelmajid; Mesbahi, Omar; Mernissi, Fatima Zahra; Amarti, Afaf

    2014-01-01

    Le dermatofibrosarcome de Darier et Ferrand (DFS) est une tumeur mésenchymateuse cutanée de malignité intermédiaire. C'est une tumeur rare mais non exceptionnelle, représentant 0,1% des tumeurs cutanées malignes. Les auteurs présentent une étude rétrospective de 27 cas de DFS diagnostiqués sur une durée de 7 ans (2004 à 2010) et la comparent aux données de la littérature. Cette étude permet d’établir en plus des caractéristiques anatomopathologiques et immunohistochimiques, une étude épidémiologique, clinique et évolutive de ce sarcome. l’âge moyen de nos patients est de 41 ans avec une prédominance masculine. Le tronc est la localisation préférentielle touché dans 52% des cas. La taille tumorale a atteint 30cm et mesure en moyenne 6,1 cm. Le diagnostic était évoqué à l'examen histologique standard et confirmé par l'expression intense et diffuse du CD34. Le traitement était chirurgical, associé à une radiothérapie dans 2 cas. L’évolution était marquée par la transformation en un sarcome pléomorphe de haut grade dans un cas et par la survenue de récidives locales dans 2 cas. Nos résultats sont classiques et comparables aux autres séries de la littérature. L'examen histologique est indispensable pour le diagnostic. L'exérèse chirurgicale large est le traitement de référence. Le pronostic est conditionné par une malignité surtout locale et un fort potentiel de récidive. La transformation sarcomateuse franchement maligne métastasiante est exceptionnelle. PMID:25489374

  17. Le syndrome de cushing chez l'adolescent: à propos de 18 patients

    PubMed Central

    Haraj, Nassim Essabah; El Aziz, Siham; Chadli, Asma

    2015-01-01

    Le syndrome de Cushing est une pathologie rare mais grave chez l'enfant et l'adolescent. Elle diffère de la pathologie adulte par le mode de présentation et la prise en charge. Il s'agit d'une étude rétrospective des dossiers de patients suivis pour syndrome de Cushing au service d'endocrinologie de Casablanca entre 2002 - 2015, incluant les patients âgés au moment du diagnostic de moins de 22 ans, et ayant un suivi d'au moins 1 an. Au total 18 dossiers ont été inclus. L’âge moyen est de 19,55 ans, avec une prédominance féminine. La durée d’évolution moyenne est de 4,05 ans. Le tableau clinique est fait souvent d'une cassure de poids, une obésité ou une séborrhée et acné. La démarche diagnostique est comparable à celle de l'adulte. Sur le plan étiologique on retrouve une prédominance de la maladie de Cushing (15 patients). Sur le plan thérapeutique, 14 patients ont bénéficié d'une chirurgie hypophysaire, avec complément par radiothérapie chez 3 patients devant l’échec de la chirurgie, Une ablation d'une tumeur surrénalienne chez une patiente et une surrénalectomie bilatérale chez trois patients. L’évolution a été marquée par une guérison chez 9 patients et le décès chez 4 (suite à un syndrome de Nelson, infection sévère, choc hémorragique, corticosurrénalome). Les résultats de cette étude soulignent la gravité de cette maladie, ce qui nécessite d'organiser le suivi, en élaborant des programmes spécifiques de suivi médical et de prise en charge psychologique. PMID:26985265

  18. Suivi après le traitement du cancer du sein

    PubMed Central

    Sisler, Jeffrey; Chaput, Geneviève; Sussman, Jonathan; Ozokwelu, Emmanuel

    2016-01-01

    Résumé Objectif Offrir aux médecins de famille un résumé des recommandations fondées sur les données probantes pour guider les soins aux survivantes traitées pour le cancer du sein. Qualité des données Une recherche documentaire a été effectuée dans MEDLINE entre 2000 et 2016 à l’aide des mots-clés anglais suivants : breast cancer, survivorship, follow-up care, aftercare, guidelines et survivorship care plans, en se concentrant sur la revue des lignes directrices publiées récemment par les organismes nationaux de cancérologie. Les données étaient de niveaux I à III. Message principal Les soins aux survivantes comportent 4 facettes : surveillance et dépistage, prise en charge des effets à long terme, promotion de la santé et coordination des soins. La surveillance des récidives ne se traduit que par une mammographie annuelle, et le dépistage d’autres cancers doit suivre les lignes directrices basées sur la population. La prise en charge des effets à long terme du cancer et de son traitement aborde des problèmes courants tels la douleur, la fatigue, le lymphœdème, la détresse et les effets indésirables des médicaments, de même que les préoccupations à long terme comme la santé du cœur et des os. La promotion de la santé met en relief les bienfaits de l’activité chez les survivantes du cancer, avec l’accent mis sur l’activité physique. Les soins aux survivantes sont de meilleure qualité lorsque divers services et professionnels de la santé participent aux soins, et le médecin de famille joue un rôle important dans la coordination des soins. Conclusion Les médecins de famille sont de plus en plus souvent les principaux fournisseurs de soins de suivi après le traitement du cancer du sein. Le cancer du sein doit être considéré comme une affection médicale chronique, même chez les femmes en rémission, et les patientes profitent de la même approche que celle utilisée pour les autres affections chroniques en

  19. Anthrax lethal toxin (LeTx) neutralization by PA domain specific antisera.

    PubMed

    Verma, Monika; Suryanarayana, Nagendra; Tuteja, Urmil; Thavachelvam, Kulanthaivel; Rao, M K; Bhargawa, Rakesh; Shukla, Sangeeta

    2017-09-14

    Anthrax associated causalities in humans and animals are implicated mainly due to the action of two exotoxins that are secreted by the bacterium Bacillus antharcis during the infection. These exotoxins comprise of three protein components namely protective antigen (PA), lethal factor (LF) and edema factor (EF). The protective antigen is the common toxin component required to form both lethal toxin (LeTx) and edema toxin (EdTx). The LeTx is formed, when PA combines with LF and EdTx is formed when PA combines with EF. Therapeutic interventions aiming to neutralise these key effectors of anthrax pathology would therefore, provide an effective means to counter the toxicity imposed by the anthrax toxins on the host. The present work describes the lethal toxin neutralization potential of polyclonal antisera developed against the individual domains of the protective antigen component of the anthrax toxin. The individual domains were produced as recombinant proteins in E. coli and validated with peptide mass fingerprinting by MALDI-TOF analysis and corresponding mice polyclonal antisera by western blotting. Each domain specific antibody titre and isotype was ascertained by ELISA. The isotyping revealed the predominance of IgG1 isotype. The toxin neutralizing potential of these domain specific antisera were evaluated by in-vitro cell viability MTT assay, employing J774.1 mouse macrophage cell line against LeTx (0.25 μg ml(-1) PA and 0.125 μg ml(-1) LF concentrations). Among the four domain specific antisera, the antiserum against PA domain IV could neutralize LeTx with high efficiency. No significant neutralization of LeTx was observed with other domain specific antibodies. Results indicate that antibodies to r-PA domain IV could be explored further as therapeutic anti toxin molecule along with appropriate antibiotic regimens against anthrax. Copyright © 2017. Published by Elsevier Ltd.

  20. Trends in hailstorm frequency in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; García, C.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The Community of Castile-León is located in the NW of the Iberian Peninsula. One of the most frequent meteorological risks in the Community during the summer is hailstorms. On average, in the Province of León, there are 42 days with storms, almost half of them being hailstorms. However, the spatial variability of the storms is very elevated. The majority of these episodes are registered in mountainous areas during the summer months and they have a convective origin. In the present study, making use of the data from the AEMET's meteorological stations situated in Castile and León, we analyzed trends in the frequency of the appearance of this type of storm from the year 1940 until the present. One of the principal problems we found is that the quality of databases generated from the years without hail precipitation data available are frequent. This is due, in large part, to the difficulty in detecting this type of meteor in meteorological stations, given their large spatial variability and their ephemeral character. On the other hand, with the objective of performing a meteorological analysis of the results found, we have also studied the trends in days with rain and the absolute maximum temperature. The overall analysis of results found allowed us to affirm a large variability in the different regions related to climatic hail series and trends found in those regions. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: CEN20091028; GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22 ).