Science.gov

Sample records for le porc sus

  1. [Structural recovering in Andean successional forests from Porce (Antioquia, Colombia)].

    PubMed

    Yepes, Adriana P; del Valle, Jorge I; Jaramillo, Sandra L; Orrego, Sergio A

    2010-03-01

    Places subjected to natural or human disturbance can recover forest through an ecological process called secondary succession. Tropical succession is affected by factors such as disturbances, distance from original forest, surface configuration and local climate. These factors determine the composition of species and the time trend of the succession itself. We studied succession in soils used for cattle ranching over various decades in the Porce Region of Colombia (Andean Colombian forests). A set of twenty five permanent plots was measured, including nine plots (20 x 50 m) in primary forests and sixteen (20 x 25 m) in secondary forests. All trees with diameter > or =1.0 cm were measured. We analyzed stem density, basal area, above-ground biomass and species richness, in a successional process of ca. 43 years, and in primary forests. The secondary forests' age was estimated in previous studies, using radiocarbon dating, aerial photographs and a high-resolution satellite image analysis (7 to >43 years). In total, 1,143 and 1,766 stems were measured in primary and secondary forests, respectively. Basal area (5.7 to 85.4 m2 ha(-1)), above-ground biomass (19.1 to 1,011.5 t ha(-1)) and species richness (4 to 69) directly increased with site age, while steam density decreased (3,180 to 590). Diametric distributions were "J-inverted" for primary forests and even-aged size-class structures for secondary forests. Three species of palms were abundant and exclusive in old secondary forests and primary forests: Oenocarpus mapora, Euterpe precatoria and Oenocarpus bataua. These palms happened in cohorts after forest disturbances. Secondary forest structure was 40% in more than 43 years of forest succession and indicate that many factors are interacting and affecting the forests succession in the area (e.g. agriculture, cattle ranching, mining, etc.).

  2. Middle Stone Age Ochre Processing and Behavioural Complexity in the Horn of Africa: Evidence from Porc-Epic Cave, Dire Dawa, Ethiopia

    PubMed Central

    Rosso, Daniela Eugenia; Pitarch Martí, Africa; d’Errico, Francesco

    2016-01-01

    Ochre is a common feature at Middle Stone Age (MSA) sites and has often been interpreted as a proxy for the origin of modern behaviour. However, few ochre processing tools, ochre containers, and ochre-stained artefacts from MSA contexts have been studied in detail within a theoretical framework aimed at inferring the technical steps involved in the acquisition, production and use of these artefacts. Here we analyse 21 ochre processing tools, i.e. upper and lower grindstones, and two ochre-stained artefacts from the MSA layers of Porc-Epic Cave, Dire Dawa, Ethiopia, dated to ca. 40 cal kyr BP. These tools, and a large proportion of the 4213 ochre fragments found at the site, were concentrated in an area devoted to ochre processing. Lower grindstones are made of a variety of raw materials, some of which are not locally available. Traces of use indicate that different techniques were employed to process ochre. Optical microscopy, XRD, μ-Raman spectroscopy, and SEM-EDS analyses of residues preserved on worn areas of artefacts show that different types of ferruginous rocks were processed in order to produce ochre powder of different coarseness and shades. A round stone bearing no traces of having been used to process ochre is half covered with residues as if it had been dipped in a liquid ochered medium to paint the object or to use it as a stamp to apply pigment to a soft material. We argue that the ochre reduction sequences identified at Porc-Epic Cave reflect a high degree of behavioural complexity, and represent ochre use, which was probably devoted to a variety of functions. PMID:27806067

  3. Middle Stone Age Ochre Processing and Behavioural Complexity in the Horn of Africa: Evidence from Porc-Epic Cave, Dire Dawa, Ethiopia.

    PubMed

    Rosso, Daniela Eugenia; Pitarch Martí, Africa; d'Errico, Francesco

    2016-01-01

    Ochre is a common feature at Middle Stone Age (MSA) sites and has often been interpreted as a proxy for the origin of modern behaviour. However, few ochre processing tools, ochre containers, and ochre-stained artefacts from MSA contexts have been studied in detail within a theoretical framework aimed at inferring the technical steps involved in the acquisition, production and use of these artefacts. Here we analyse 21 ochre processing tools, i.e. upper and lower grindstones, and two ochre-stained artefacts from the MSA layers of Porc-Epic Cave, Dire Dawa, Ethiopia, dated to ca. 40 cal kyr BP. These tools, and a large proportion of the 4213 ochre fragments found at the site, were concentrated in an area devoted to ochre processing. Lower grindstones are made of a variety of raw materials, some of which are not locally available. Traces of use indicate that different techniques were employed to process ochre. Optical microscopy, XRD, μ-Raman spectroscopy, and SEM-EDS analyses of residues preserved on worn areas of artefacts show that different types of ferruginous rocks were processed in order to produce ochre powder of different coarseness and shades. A round stone bearing no traces of having been used to process ochre is half covered with residues as if it had been dipped in a liquid ochered medium to paint the object or to use it as a stamp to apply pigment to a soft material. We argue that the ochre reduction sequences identified at Porc-Epic Cave reflect a high degree of behavioural complexity, and represent ochre use, which was probably devoted to a variety of functions.

  4. Click-chemistry approach to study mycoloylated proteins: Evidence for PorB and PorC porins mycoloylation in Corynebacterium glutamicum.

    PubMed

    Issa, Hanane; Huc-Claustre, Emilie; Reddad, Thamila; Bonadé Bottino, Nolwenn; Tropis, Maryelle; Houssin, Christine; Daffé, Mamadou; Bayan, Nicolas; Dautin, Nathalie

    2017-01-01

    Protein mycoloylation is a recently identified, new form of protein acylation. This post-translational modification consists in the covalent attachment of mycolic acids residues to serine. Mycolic acids are long chain, α-branched, β-hydroxylated fatty acids that are exclusively found in the cell envelope of Corynebacteriales, a bacterial order that includes important genera such as Mycobacterium, Nocardia or Corynebacterium. So far, only 3 mycoloylated proteins have been identified: PorA, PorH and ProtX from C. glutamicum. Whereas the identity and function of ProtX is unknown, PorH and PorA associate to form a membrane channel, the activity of which is dependent upon PorA mycoloylation. However, the exact role of mycoloylation and the generality of this phenomenon are still unknown. In particular, the identity of other mycoloylated proteins, if any, needs to be determined together with establishing whether such modification occurs in Corynebacteriales genera other than Corynebacterium. Here, we tested whether a metabolic labeling and click-chemistry approach could be used to detect mycoloylated proteins. Using a fatty acid alkyne analogue, we could indeed label PorA, PorH and ProtX and determine ProtX mycoloylation site. Importantly, we also show that two other porins from C. glutamicum, PorB and PorC are mycoloylated.

  5. Click-chemistry approach to study mycoloylated proteins: Evidence for PorB and PorC porins mycoloylation in Corynebacterium glutamicum

    PubMed Central

    Issa, Hanane; Huc-Claustre, Emilie; Reddad, Thamila; Bonadé Bottino, Nolwenn; Tropis, Maryelle; Houssin, Christine; Daffé, Mamadou; Bayan, Nicolas

    2017-01-01

    Protein mycoloylation is a recently identified, new form of protein acylation. This post-translational modification consists in the covalent attachment of mycolic acids residues to serine. Mycolic acids are long chain, α-branched, β-hydroxylated fatty acids that are exclusively found in the cell envelope of Corynebacteriales, a bacterial order that includes important genera such as Mycobacterium, Nocardia or Corynebacterium. So far, only 3 mycoloylated proteins have been identified: PorA, PorH and ProtX from C. glutamicum. Whereas the identity and function of ProtX is unknown, PorH and PorA associate to form a membrane channel, the activity of which is dependent upon PorA mycoloylation. However, the exact role of mycoloylation and the generality of this phenomenon are still unknown. In particular, the identity of other mycoloylated proteins, if any, needs to be determined together with establishing whether such modification occurs in Corynebacteriales genera other than Corynebacterium. Here, we tested whether a metabolic labeling and click-chemistry approach could be used to detect mycoloylated proteins. Using a fatty acid alkyne analogue, we could indeed label PorA, PorH and ProtX and determine ProtX mycoloylation site. Importantly, we also show that two other porins from C. glutamicum, PorB and PorC are mycoloylated. PMID:28199365

  6. Taxonomy: Sus bucculentus revisited.

    PubMed

    Robins, Judith H; Ross, Howard A; Allen, Melinda S; Matisoo-Smith, Elizabeth

    2006-04-13

    In 1997, the rediscovery of Sus bucculentus in Laos was announced by Groves et al.--this wild pig species had gone unrecorded since first being described in 1892. Although the identification of the new specimen was based initially on morphology, the authors also used a 7% sequence divergence from the common Eurasian pig S. scrofa (based on their analysis of 327 base pairs of the gene encoding mitochondrial 12S ribosomal RNA) as support for the species status of S. bucculentus. Concerned about the large divergence reported for a relatively conserved gene, and the absence of the sequence in any public database, we analysed an additional tissue sample from the specimen and found only 0.6% divergence from S. scrofa. Our more extensive analysis places the sample within the S. scrofa clade, calling into question the species status of S. bucculentus and demonstrating the need for both phylogenetic and morphological evidence in defining species.

  7. Le Figaro. Revised.

    ERIC Educational Resources Information Center

    Crawford, Linda

    These instructional materials are designed for students with some French reading skills and vocabulary in late beginning or early intermediate senior high school French. The objectives are to introduce students to a French newspaper, "Le Figaro," and develop reading skills for skimming, gathering specific information, and relying on cognates. The…

  8. Le mouvement du pôle

    NASA Astrophysics Data System (ADS)

    Bizouard, Christian

    2012-03-01

    Les variations de la rotation terrestre. En conditionnant à la fois notre vie quotidienne, notre perception du ciel, et bon nombre de phénomènes géophysiques comme la formation des cyclones, la rotation de la Terre se trouve au croisement de plusieurs disciplines. Si le phenomena se faisait uniformément, le sujet serait vite discuté, mais c'est parce que la rotation terrestre varie, même imperceptiblement pour nos sens, dans sa vitesse angulaire comme dans la direction de son axe, qu'elle suscite un grand intérêt. D'abord pour des raisons pratiques : non seulement les aléas de la rotation terrestre modi_ent à la longue les pointés astrométriques à un instant donné de la journée mais in_uencent aussi les mesures opérées par les techniques spatiales ; en consequence l'exploitation de ces mesures, par exemple pour déterminer les orbites des satellites impliqués ou pratiquer le positionnement au sol, nécessite une connaissance précise de ces variations. Plus fondamentalement, elles traduisent les propriétés globales de la Terre comme les processus physiques qui s'y déroulent, si bien qu'en analysant les causes des fluctuations observées, on dispose d'un moyen de mieux connaître notre globe. La découverte progressive des fluctuations de la rotation de la Terre a une longue histoire. Sous l'angle des techniques d'observation, trois époques se pro-celle du pointé astrométrique à l'oeil nu, à l'aide d'instruments en bois ou métalliques (quart de cercle muraux par exemple). À partir du XVIIe siècle débute l'astrométrie télescopique dont les pointés sont complétés par des datations de plus en plus précises grâce à l'invention d'horloges régulées par balancier. Cette deuxième époque se termine vers 1960, avec l'avènement des techniques spatiales : les pointés astrométriques sont délaissés au profit de la mesure ultra-précise de durées ou de fréquences de signaux électromagnétiques, grâce à l'invention des horloges

  9. Streptococcus pneumoniae, le transformiste.

    PubMed

    Johnston, Calum; Campo, Nathalie; Bergé, Matthieu J; Polard, Patrice; Claverys, Jean-Pierre

    2014-03-01

    Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Natural genetic transformation, which was discovered in this species, involves internalization of exogenous single-stranded DNA and its incorporation into the chromosome. It allows acquisition of pathogenicity islands and antibiotic resistance and promotes vaccine escape via capsule switching. This opinion article discusses how recent advances regarding several facets of pneumococcal transformation support the view that the process has evolved to maximize plasticity potential in this species, making the pneumococcus le transformiste of the bacterial kingdom and providing an advantage in the constant struggle between this pathogen and its host.

  10. NEP facilities (LeRC)

    NASA Technical Reports Server (NTRS)

    Vetrone, Robert H.

    1993-01-01

    The topics are presented in viewgraph form and include the following: the Electric Propulsion Research Building (no. 16) the Electric Power Laboratory (BLDG. 301); the Tank 6 Vacuum Facility; and test facilities for electric propulsion and LeRC.

  11. Le bégaiement

    PubMed Central

    Perez, Hector R.; Stoeckle, James H.

    2016-01-01

    Résumé Objectif Fournir une mise à jour sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental. Qualité des données Une recherche d’études récentes ou non portant sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental a été effectuée dans les bases de données MEDLINE et Cochrane. La plupart des recommandations s’appuient sur des études de petite envergure, des données probantes de qualité limitée ou des consensus. Message principal Le bégaiement est un trouble d’élocution fréquent chez les personnes de tous âges, il altère la fluidité verbale normale et l’enchaînement du discours. Le bégaiement a été lié à des différences de l’anatomie, du fonctionnement et de la régulation dopaminergique du cerveau qui seraient de source génétique. Il importe de poser le diagnostic avec attention et de faire les recommandations qui conviennent chez les enfants, car de plus en plus, le consensus veut que l’intervention précoce par un traitement d’orthophonie soit cruciale chez les enfants bègues. Chez les adultes, le bégaiement est lié à une morbidité psychosociale substantielle, dont l’anxiété sociale et une piètre qualité de vie. Les traitements pharmacologiques ont soulevé l’intérêt depuis quelques années, mais les données cliniques sont limitées. Le traitement des enfants et des adultes repose sur l’orthophonie. Conclusion De plus en plus de recherches ont tenté de lever le voile sur la physiopathologie du bégaiement. La meilleure solution pour les enfants et les adultes bègues demeure la recommandation à un traitement d’orthophonie.

  12. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne lele de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  13. Les hommes regardent le ciel.

    NASA Astrophysics Data System (ADS)

    Jaschek, C.

    Contents: 1. Le ciel nocturne. 2. Le mouvement du soleil. 3. La lune et ses mouvements. 4. L'orientation des bâtiments. 5. Les étoiles et les constellations. 6. Les planètes. 7. Les comètes, météores et météorites. 8. Les phénomènes météorologico-astronomiques. 9. Les éclipses. 10. Le temps et les calendriers. 11. Astres et destinée humaine - l'astrologie. 12. Les mythes de la création du monde. 13. Les mythes de la fin du monde. 14. Astronomie et société.

  14. Laser bendability of SUS430/C11000/SUS430 laminated composite and its constituent layers

    NASA Astrophysics Data System (ADS)

    Hossein Seyedkashi, S. M.; Gollo, Mohammad Hoseinpour; Biao, Jin; Moon, Young Hoon

    2016-05-01

    Laminated composites are of great interest in different industries while having the advantages of all base metals. In this research, the laser bending of a three-layered SUS430/C11000/SUS430 laminated composite is characterized both experimentally and numerically. This composite can be used in the microelectronics industry since it has the anti-corrosion and strength capability of stainless steel, and the electrical superiority of copper. The specimens are bent using a Ytterbium fiber laser irradiated on a straight path along the sheet width. The effects of bending parameters including the number of passes, scanning velocity, beam diameter, laser power and delay time between passes are examined for a three-layered laminated sheet, and compared with its constituent steel and copper layers. It is found that the thin copper mid-layer strongly affects the rate of bending per pass. Heat distribution and plastic strain along the thickness during the process are characterized by using the finite element method. The Cu mid-layer decreases the bending angle, but also postpones the onset of melting, and thus can be compensated by the application of higher laser powers. It is shown that the bending angle increases with an increase in laser power and delay time, and a decrease in laser velocity and beam diameter.

  15. Le verifiche della relatività generale

    NASA Astrophysics Data System (ADS)

    Tempesti, Piero

    2005-10-01

    La relatività di Einstein. La relatività generale messa alla prova. Le tre verifiche classiche: L'avanzamento del perielio di Mercurio - La deflessione della luce - Il redshift gravitazionale. Le verifiche di seconda generazione: Il rallentamento della luce - L'effetto Nordtvedt - Le onde gravitazionali e la "pulsar binaria".

  16. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-12-01

    XMM à la recherche de la matière exotique; Ancienne étoile; Le Trou noir volant; Magnétar; Stardust et Annefrank; Le centre de la galaxie; Deux trous noirs dans la même galaxie; Eruption géante sur Io; Le Soleil;

  17. Le LHC, un tunnel cosmique

    ScienceCinema

    None

    2016-07-12

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  18. LeFort I Osteotomy

    PubMed Central

    Buchanan, Edward P.; Hyman, Charles H.

    2013-01-01

    The LeFort I osteotomy is one of the most commonly used procedures to correct midface deformities. It allows for correction in three dimensions including advancement, retrusion, elongation, and shortening. It is indicated, often in conjunction with mandibular surgery, for class II and III malocclusion, facial asymmetry, obstructive sleep apnea, and maxillary atrophy. Before surgery, proper orthodontics and surgical planning should be undertaken to ensure adequate outcomes. Overall, the surgery is widely used due to its low complication profile and reliable long-term results. PMID:24872761

  19. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-09-01

    Fragmentation et astéroïdes binaires; Astéroïde géocroiseur triple; Rosetta sort de son hibernation; Messenger; Transit lunaire vu par Deep Impact; Titan; Phobos; Phoenix; Einstein avait raison; Le ballet des taches rouges; Le poids des lentilles;

  20. 2014 Higher Education Summit/SUS Data Workshop Proceedings

    ERIC Educational Resources Information Center

    Board of Governors, State University System of Florida, 2014

    2014-01-01

    Information Resource Management--State University System of Florida (IRM-SUS) is the primary collector and provider of data concerning state universities that is used to make sound education policy decisions. The office provides technical assistance to those using the information, state and federal reporting support, those supplying information,…

  1. Bovine tuberculosis in a wild boar (Sus scrofa) in Poland.

    PubMed

    Krajewska, Monika; Lipiec, Marek; Zabost, Anna; Augustynowicz-Kopeć, Ewa; Szulowski, Krzysztof

    2014-10-01

    Poland is officially tuberculosis free and bovine tuberculosis (BTB) cases are rarely found except in bovids. We found BTB in a wild boar (Sus scrofa) in the Bieszczady Mountains, southeastern Poland. Studies suggest possible transmission of infection between free-living European bison (Bison bonasus caucasicus) and wild boar in this area.

  2. Le syndrome d'apert

    PubMed Central

    Benmiloud, Sarra; Chaouki, Sana; Atmani, Samir; Hida, Moustapha

    2013-01-01

    Le syndrome d'Apert est une affection congénitale rare, caractérisée par une sténose cranio-faciale associée à une syndactylie des mains et des pieds. Sa prise en charge doit être précoce et multidisciplinaire. Sa gravité réside dans la coexistence de plusieurs malformations avec un risque d'hypertension intracrânienne chronique responsable d'une cécité et d'une débilité mentale. Les auteurs rapportent une nouvelle observation à travers laquelle ils illustrent les aspects cliniques et évolutifs ainsi que les difficultés thérapeutiques de cette affection. PMID:23565313

  3. Le Point sur... Astronomie IV

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    Cet ouvrage regroupe des articles de mise au point sollicités par le rédacteur en chef de la rubrique Astronomie des Comptes rendus de l'Académie des sciences. Les textes se proposent de faire découvrir aux lecteurs, dans les principales disciplines de l'astronomie, les résultats les plus remarquables des dernières années.Leurs auteurs sont des spécialistes participant activement à l'accroissement des connaissances dans des domaines faisant l'objet de recherches intensives. Ces mises au point sur des questions particulièrement importantes de l'astronomie sont rédigées soit en français, soit en anglais et accompagnées d'une bibliographie détaillée.

  4. Intraday LeBaron effects

    PubMed Central

    Bianco, Simone; Corsi, Fulvio; Renò, Roberto

    2009-01-01

    We study the relation at intraday level between serial correlation and volatility of the Standard and Poor (S&P) 500 stock index futures returns. At daily and weekly levels, serial correlation and volatility forecasts have been found to be negatively correlated (LeBaron effect). After finding a significant attenuation of the original effect over time, we show that a similar but more pronounced effect holds by using intraday measures, by such as realized volatility and variance ratio. We also test the impact of unexpected volatility, defined as the part of volatility which cannot be forecasted, on the presence of intraday serial correlation in the time series by employing a model for realized volatility based on the heterogeneous market hypothesis. We find that intraday serial correlation is negatively correlated to volatility forecasts, whereas it is positively correlated to unexpected volatility.

  5. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-12-01

    ISON; (3200) Phaéton; Titan, lacs et hydrocarbures; Titan et le Soleil; Jets; z8_GND_5296; La nébuleuse de la Crevette; Planète isolée; Nébuleuse Toby Jug; Le pulsar du Crabe; Le bulbe de la Voie lactée; ALMA au grand complet; APEX, ArTéMiS; Sgr A*; Première détection de l’acétate de méthyle dans l’espace

  6. Jan Potocki et le "Gothic Novel"

    ERIC Educational Resources Information Center

    Finne, Jacques

    1970-01-01

    Establishes a parallel between the supernatural and fantastic qualities of Le Comte Jan Potocki's literary works, and the English gothic novels by comparing the elements of terror, mysterious atmosphere, and the supernatural beings involved. (DS)

  7. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-06-01

    Deep Impact; Comète 73P/Schwassmann-Wachmann 3; L'anneau bleu d'Uranus; Triplet de neptunes; Triton; Dunes de Titan; Aréologie; Tache Rouge Junior; Obliquité des grosses planètes; Le jour de Saturne; Xéna; Un compagnon pour le Soleil; Galaxies satellites; Séisme sur une étoile à neutrons; Trou noir double; Hydrogène lointain

  8. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2005-03-01

    Trou noir glouton, Matière noire, Integral et le centre de notre Galaxie, Essaim de trous noirs, Carrousel autour de trous noirs, Érosion de trous noirs, Un quasar dans NGC 7319?, Distance de T Tauri, Chai non manquant, Des planètes autour d'une naine brune?, Titan, Une quatrième planète pour le pulsar PSR B1257+12, Smart 1, Aurores de Saturne

  9. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-02-01

    le errant; Pluton et Charon; Du côté d'Uranus !; Stardust; G29-38; La chasse aux planètes; Étoile polaire; Véga; Vers un interféromètre infrarouge à base kilométrique; Des pulsars extraordinaires; Trous noirs intermédiaires; Le trou noir central de la Galaxie; N44; Tornade spatiale

  10. La Vie Politique sous la Restauration a Travers ’Le Rouge et le Noir’ de Stendahl (The Political Life during the Restauration as Depicted in Le Rouge et le Noir by Stendahl)

    DTIC Science & Technology

    1989-01-01

    Valenod et Moirod, qul hissent le drapeau lib6ral uniquenient pour aznoIiorer leurs propres 20 conditions. Ils n’ont ni souci pour les paysans ni... propre benefice. Le lecteur est introduit a M. Valenod tres t~t dans le livre. 11 est le directeur du depot de mendicit6 A Verrlieres qui craint la visite... propres desse ins. Le groupe de vrais lib~t-aux stendhal lens comprend Fouqu6 qui est le bon ami de Julilen Sorel , le phi losophe Saint- Giraud. et

  11. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  12. Intestinal protozoa in wild boars (Sus scrofa) in western Iran.

    PubMed

    Solaymani-Mohammadi, S; Rezaian, M; Hooshyar, H; Mowlavi, G R; Babaei, Z; Anwar, M A

    2004-10-01

    A total of 12 gastrointestinal tracts of wild boars (Sus scrofa) from western Iran (Luristan) were examined for protozoan infection between September 2000 and November 2001. Of 12 boars examined, 67% harbored one or more species of the following protozoa: Balantidium coli (25%), Tritrichomonas suis (25%), Blastocystis sp. (25%), Entamoeba polecki (17%), Entamoeba suis (8%), Iodamoeba butschlii (17%), and Chilomastix mesnili (8%). Four of these protozoan species also are reported in humans, and persons living in rural areas where wild boars are abundant should take precaution to avoid infection.

  13. The financing of SUS in a scenario of financialization.

    PubMed

    Mendes, Aquilas; Marques, Rosa Maria

    2009-01-01

    This article rebuilds the process of the institutionalization process of the financing of Unified Health System (SUS), impaired, initially, by the macroeconomic policy conditions, developed during the decades of 1990 and 2000, and, ultimately, by the effects caused by the present phase of capitalism, concerning financial capital supremacy. It also identifies, within the political and economic framework, conflicts existing with the economic area of the federal government, highlighting the conditions imposed to financing and the concept of health, being universal and an essential component of Social Security.

  14. Polarization-controlled optical ring cavity (PORC) tunable pulse stretcher

    NASA Astrophysics Data System (ADS)

    Williamson, Andrew P.; Kiefer, Johannes

    2016-08-01

    A new concept and a theoretical approach for modeling a tunable polarization-controlled optical ring cavity pulse stretcher is demonstrated. The technique discussed herein permits highly simplified and flexible tuning of the temporal shape of nanosecond duration pulses. Using half-wave plates positioned extra- and intracavity, transmission to reflection ratios across both input faces of a polarization beam splitter can easily be controlled. The resulting models indicate a further reduction in peak intensity of 30%, with respect to conventional dielectric beam splitting optical ring cavities, when configured under equivalent and optimized cavity settings.

  15. Les Brulures Chimiques Par Le Laurier Rose

    PubMed Central

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Summary Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose de gravité différente. Cela doit aboutir à une information élargie de la population, ainsi qu'une réglementation stricte de sa commercialisation. PMID:21991211

  16. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-06-01

    Future lune ? - L'âge de la Lune - Des volcans actifs sur Vénus - Un lac dans le cratère Gusev ? - Météorites et atmosphère martiennes - L’hexagone de Saturne - Pluton - Exo-Terre - Bêta Pictoris b - Cérès et Vesta depuis Mars - Naine froide - Parallaxes par Hubble - L2 Puppis et le sort du Soleil - Supernova et lentille gravitationnelle - Champ magnétique galactique - L’objet de Sakurai - Fermi et la matière noire - Lentille naine

  17. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-09-01

    Jeunes étoiles et vieilles galaxies; Chiens de Chasse; Des images en partie belges; Détection chimique de planètes?; Amas cannibale; Le pulsar œil de bœuf; Supernova 2002 DJ; Centaurus A; Et de cent; Près du trou noir; Un cratère sous la Merdu Nord; Des astéroï des frôlent la Terre; Photons fatigués; Taches solaires; Un grand lac martien; Les naines brunes en infrarouge; Bourrelet équatorial; Fusion de trous noirs; Le hamburger de Gomez; Matière sombre; Non aux étoiles à quarks

  18. Le continu contre l'espace

    NASA Astrophysics Data System (ADS)

    Salanskis, Jean-Michel

    Disons pour conclure que, en tout état de cause, la façon de concevoir philosophiquement le conflit du continu et de l'espace que nous avons trouvée chez Hegel n'est pas homogène avec le style et les modalités de la pensée mathématique: 1) d'une part, le lien classique, le lien de référence entre continu et espace en mathématiques n'est pas que l'espace serait premier et privé de pensée, et le continu second, venant dissoudre l'espace en apportant la qualité, l'infini et la pensée, mais tout au contraire, il consiste en ce que l'espace est fondé sur l'abîme infinitaire du continu ; 2) d'autre part, l'éventuel divorce entre l'espace et le continu dans l'aire mathématique n'est pas celui d'une réflexivité purement conceptuelle du continu avec un positivisme géométrique, n'équivaut pas à une rupture disciplinaire ; il est plutôt le symptôme de la dérive d'une herméneutique à l'égard d'une autre, au sein d'un continent juridique commun définissant la discipline (la mathématique ensembliste), cette dérive pouvant, à la limite, induire une refonte de ce sol juridique, sans que jamais il soit question pour autant de nier l'unité des mathématiques, à comprendre ici comme l'unité ultime de responsabilité de la communauté mathématique à l'égard des trois questions Qu'est-ce que l'espace?”, “Qu'est-ce que le continu?” et “Qu'est-ce que l'infini?”.

  19. Serological anthrax surveillance in wild boar (Sus scrofa) in Ukraine.

    PubMed

    Bagamian, Karoun H; Skrypnyk, Artem; Rodina, Yana; Bezymennyi, Maksym; Nevolko, Oleg; Skrypnyk, Valeriy; Blackburn, Jason K

    2014-08-01

    Anthrax, caused by Bacillus anthracis, is an acute disease affecting wildlife, livestock, and humans worldwide, although its impact on these populations is underappreciated. In Ukraine, surveillance is passive, and anthrax is often detected in livestock. However, wildlife is not subject to surveillance, although anthrax deaths (such as in wild boar, Sus scrofa) have been documented. The wild boar is a plentiful and widespread species in Ukraine and is frequently hunted. We initiated a screening study testing Ukrainian wild boar blood samples for antibodies to B. anthracis. We mapped results relative to known livestock anthrax hotspots. We discovered evidence of exposure in wild boar up to 35 km from livestock anthrax hotspots and over 400 km from previous anthrax reports in boars. We make recommendations about using wildlife species as biosentinels for anthrax in Ukraine.

  20. Structural Classification of Wild Boar (Sus scrofa) Vocalizations.

    PubMed

    Garcia, Maxime; Gingras, Bruno; Bowling, Daniel L; Herbst, Christian T; Boeckle, Markus; Locatelli, Yann; Fitch, W Tecumseh

    2016-04-01

    Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig (Sus scrofa domesticus) vocalizations, for example, has led to significant advances in our understanding of communicative functions. Despite their close relation to domestic pigs, little is known about wild boar (Sus scrofa) vocalizations. The few existing studies, conducted in the 1970s, relied on visual inspections of spectrograms to quantify acoustic parameters and lacked statistical analysis. Here, we use objective signal processing techniques and advanced statistical approaches to classify 616 calls recorded from semi-free ranging animals. Based on four spectral and temporal acoustic parameters-quartile Q25, duration, spectral flux, and spectral flatness-extracted from a multivariate analysis, we refine and extend the conclusions drawn from previous work and present a statistically validated classification of the wild boar vocal repertoire into four call types: grunts, grunt-squeals, squeals, and trumpets. While the majority of calls could be sorted into these categories using objective criteria, we also found evidence supporting a graded interpretation of some wild boar vocalizations as acoustically continuous, with the extremes representing discrete call types. The use of objective criteria based on modern techniques and statistics in respect to acoustic continuity advances our understanding of vocal variation. Integrating our findings with recent studies on domestic pig vocal behavior and emotions, we emphasize the importance of grunt-squeals for acoustic approaches to animal welfare and underline the need of further research investigating the role of domestication on animal vocal communication.

  1. Exome Capture with Heterologous Enrichment in Pig (Sus scrofa).

    PubMed

    Guiatti, Denis; Pomari, Elena; Radovic, Slobodanka; Spadotto, Alessandro; Stefanon, Bruno

    2015-01-01

    The discovery of new protein-coding DNA variants related to carcass traits is very important for the Italian pig industry, which requires heavy pigs with higher thickness of subcutaneous fat for Protected Designation of Origin (PDO) productions. Exome capture techniques offer the opportunity to focus on the regions of DNA potentially related to the gene and protein expression. In this research a human commercial target enrichment kit was used to evaluate its performances for pig exome capture and for the identification of DNA variants suitable for comparative analysis. Two pools of 30 pigs each, crosses of Italian Duroc X Large White (DU) and Commercial hybrid X Large White (HY), were used and NGS libraries were prepared with the SureSelectXT Target Enrichment System for Illumina Paired-End Sequencing Library (Agilent). A total of 140.2 M and 162.5 M of raw reads were generated for DU and HY, respectively. Average coverage of all the exonic regions for Sus scrofa (ENSEMBL Sus_scrofa.Sscrofa10.2.73.gtf) was 89.33X for DU and 97.56X for HY; and 35% of aligned bases uniquely mapped to off-target regions. Comparison of sequencing data with the Sscrofa10.2 reference genome, after applying hard filtering criteria, revealed a total of 232,530 single nucleotide variants (SNVs) of which 20.6% mapped in exonic regions and 49.5% within intronic regions. The comparison of allele frequencies of 213 randomly selected SNVs from exome sequencing and the same SNVs analyzed with a Sequenom MassARRAY® system confirms that this "human-on-pig" approach offers new potentiality for the identification of DNA variants in protein-coding genes.

  2. A Compositional Analysis of "-GUO" and "-LE."

    ERIC Educational Resources Information Center

    Mangione, L.; Li, Dingxuan

    1993-01-01

    Paper examines interaction of semantic contributions of aspect markers "-guo" and "-le"; negative adverbs "bu" and "mei"; and two classes of verbs. Proposed analysis systematically accounts for temporal orientation of members of several classes of sentences in terms of aspectual contributions made by two aspect markers, negative adverbs, verbs,…

  3. Technical Programme 1993 (Le Programme Technique, 1993)

    DTIC Science & Technology

    1992-09-01

    Symposium sur "Les Effets de la Propagation Atmospherique a travers des Obscurcissants Naturels et Artificiels sur le Rayonnement des Ondes Millimetriques...for Small Gas Turbines" Reunion du Panel et Symposium sur "Les Technologies pour les Petites Turbines a Gaz " 4-8 CANADA TIP Panel Meeting/Specialists

  4. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs…

  5. Le Chatelier's principle in replicator dynamics

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  6. Le Chatelier's principle in replicator dynamics.

    PubMed

    Allahverdyan, Armen E; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  7. Le Chatelier--Right or Wrong?

    ERIC Educational Resources Information Center

    Helfferich, Friedrich G.

    1985-01-01

    Presents a class exercise designed to find out how well students understand the nature and consequences of the mass action law and Le Chatelier's principle as applied to chemical equilibria. The exercise relates to a practical situation and provides simple relations for maximizing equilibrium quantities not found in standard textbooks. (JN)

  8. Microscopic Description of Le Chatelier's Principle

    ERIC Educational Resources Information Center

    Novak, Igor

    2005-01-01

    A simple approach that "demystifies" Le Chatelier's principle (LCP) and simulates students to think about fundamental physical background behind the well-known principles is presented. The approach uses microscopic descriptors of matter like energy levels and populations and does not require any assumption about the fixed amount of substance being…

  9. Le Chatelier's Principle, Temperature Effects, and Entropy.

    ERIC Educational Resources Information Center

    Campbell, J. Arthur

    1985-01-01

    One of the most useful methods of understanding chemical equilibria is provided by Le Chatelier's principle. The relationships between this principle, temperature, and entropy are discussed. Tables with thermodynamic data for some net reactions commonly used to illustrate the principle and for reactions involving gases are included. (JN)

  10. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-04-01

    Jets stellaires; Structure géante et matière noire; Un mini-système solaire; Arcs gravitationnels et images multiples; Choc frontal dans notre Galaxie; Avalanches martiennes; Du sable autour de KH 15D; Le cratère de Carancas; Smart-1;

  11. 30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE BASE COMPOUND, LOOKING EAST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  12. 29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE CLAIRE BASE COMPOUND, LOOKING WEST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  13. Alloimmunisation fœto-maternelle Rhésus grave à propos d'un cas et revue de la littérature

    PubMed Central

    Zineb, Benkerroum; Boutaina, Lachiri; Ikram, Lazrak; Driss, Moussaoui Rahali; Mohammed, Dehayni

    2015-01-01

    L'incompatibilité fœto-maternelle Rhésus peut être à l'origine d'un syndrome hémolytique dont l'expression clinique est l′anémie fœtale éventuellement compliquée par une anasarque fœto-placentaire ou à l'extrême une mort fœtale in utéro. Nous rapportons l'observation d'un cas d'allo immunisation Rhésus à 34 SA ayant aboutit un hydrops foetalis, l'extraction fœtale par césarienne en vue d'une exsanguino-transfusion a été réalisée, mais le nouveau né est décédé au cours de l'exsanguino-transfusion. Le dépistage des femmes à risque et l'utilisation d'Immunoglobulines anti D ont permis une réduction importante de l′incidence des accidents d'incompatibilité. La mesure du pic systolique de vélocité dans l'artère cérébrale moyenne a bouleversé la surveillance et la prise en charge prénatale des anémies fœtales secondaires à une allo-immunisation Rhésus. Son utilisation dans la surveillance des cas d'allo-immunisation Rhésus permettrait ainsi de réserver les procédures invasives (cordocentèse) comme geste thérapeutique qui permet la transfusion fœtale in utéro. Grâce à une collaboration multidisciplinaire cohérente, l'extraction fœtale peut être programmée, ce qui permet une prise en charge adéquate et rigoureuse, même des nouveaux nés avec atteinte sévère. PMID:26889318

  14. Le syndrome d’alcoolisme foetal

    PubMed Central

    2002-01-01

    L’alcool est un tératogène physique et comportemental. Le syndrome d’alcoolisme foetal (SAF) est un trouble courant mais encore sous-diagnostiqué découlant de la consommation d’alcool par la mère pendant la grossesse. Bien qu’il puisse être prévenu, le SAF est également invalidant. Même si le SAF est présent dans tous les groupes socioéconomiques du Canada, sa prévalence est élevée dans certaines communautés inuites et des Premières nations du Canada. Le présent énoncé porte sur la prévention, le diagnostic, le dépistage précoce et la prise en charge du SAF par les professionnels de la santé. La prévention du SAF doit s’effectuer à deux échelons. La prévention primaire consiste à éliminer le SAF par une formation en classe ou dans la collectivité et à inciter les femmes à éviter de consommer de l’alcool avant la conception et pendant la grossesse. La prévention secondaire consiste à repérer les femmes qui boivent pendant leur grossesse et à réduire leur consommation. Le présent énoncé décrit plusieurs stratégies de dépistage, dont la stratégie T-ACE (tolérance-agacement, réduction, éveil). Les dispensateurs de soins devraient recommander l’abstinence dès la première visite prénatale. Un envoi rapide en consultation en vue de traiter l’alcoolisme est recommandé pour les femmes enceintes incapables d’arrêter de boire. Le présent énoncé décrit le diagnostic de SAF, de SAF partiel ou atypique, d’anomalies congénitales et de troubles neurodéveloppementaux reliés à l’alcool. En cas d’exposition à l’alcool in utero, un diagnostic de SAF devrait être envisagé en présence d’un retard de croissance courant ou antérieur, de certaines anomalies faciales touchant la lèvre supérieure et les yeux et d’anomalies neurodéveloppementales. Ces caractéristiques sont mieux quantifiées au moyen d’une méthode diagnostique à quatre chiffres. Des stratégies de dépistage précoce des

  15. An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1.

    PubMed

    AbuQattam, Ali; Gallego, José; Rodríguez-Navarro, Susana

    2016-01-01

    Sus1 is a conserved protein involved in chromatin remodeling and mRNA biogenesis. Unlike most yeast genes, the SUS1 pre-mRNA of Saccharomyces cerevisiae contains two introns and is alternatively spliced, retaining one or both introns in response to changes in environmental conditions. SUS1 splicing may allow the cell to control Sus1 expression, but the mechanisms that regulate this process remain unknown. Using in silico analyses together with NMR spectroscopy, gel electrophoresis, and UV thermal denaturation experiments, we show that the downstream intron (I2) of SUS1 forms a weakly stable, 37-nucleotide stem-loop structure containing the branch site near its apical loop and the 3' splice site after the stem terminus. A cellular assay revealed that two of four mutants containing altered I2 structures had significantly impaired SUS1 expression. Semiquantitative RT-PCR experiments indicated that all mutants accumulated unspliced SUS1 pre-mRNA and/or induced distorted levels of fully spliced mRNA relative to wild type. Concomitantly, Sus1 cellular functions in histone H2B deubiquitination and mRNA export were affected in I2 hairpin mutants that inhibited splicing. This work demonstrates that I2 structure is relevant for SUS1 expression, and that this effect is likely exerted through modulation of splicing.

  16. An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1

    PubMed Central

    AbuQattam, Ali; Gallego, José; Rodríguez-Navarro, Susana

    2016-01-01

    Sus1 is a conserved protein involved in chromatin remodeling and mRNA biogenesis. Unlike most yeast genes, the SUS1 pre-mRNA of Saccharomyces cerevisiae contains two introns and is alternatively spliced, retaining one or both introns in response to changes in environmental conditions. SUS1 splicing may allow the cell to control Sus1 expression, but the mechanisms that regulate this process remain unknown. Using in silico analyses together with NMR spectroscopy, gel electrophoresis, and UV thermal denaturation experiments, we show that the downstream intron (I2) of SUS1 forms a weakly stable, 37-nucleotide stem–loop structure containing the branch site near its apical loop and the 3′ splice site after the stem terminus. A cellular assay revealed that two of four mutants containing altered I2 structures had significantly impaired SUS1 expression. Semiquantitative RT-PCR experiments indicated that all mutants accumulated unspliced SUS1 pre-mRNA and/or induced distorted levels of fully spliced mRNA relative to wild type. Concomitantly, Sus1 cellular functions in histone H2B deubiquitination and mRNA export were affected in I2 hairpin mutants that inhibited splicing. This work demonstrates that I2 structure is relevant for SUS1 expression, and that this effect is likely exerted through modulation of splicing. PMID:26546116

  17. Results of fracture mechanics tests on PNC SUS 304 plate

    SciTech Connect

    Mills, W.J.; James, L.A.; Blackburn, L.D.

    1985-08-01

    PNC provided SUS 304 plate to be irradiated in FFTF at about 400/sup 0/C to a target fluence of 5 x 10/sup 21/ n/cm/sup 2/ (E > 0.1 MeV). The actual irradiation included two basically different exposure levels to assure that information would be available for the exposure of interest. After irradiation, tensile properties, fatigue-crack growth rates and J-integral fracture toughness response were determined. These same properties were also measured for the unirradiated material so radiation damage effects could be characterized. This report presents the results of this program. It is expected that these results would be applicable for detailed fracture analysis of reactor components. Recent advances in elastic-plastic fracture mechanics enable reasonably accurate predictions of failure conditions for flawed stainless steel components. Extensive research has focused on the development of J-integral-based engineering approach for assessing the load carrying capacity of low-strength, high-toughness structural materials. Furthermore, Kanninen, et al., have demonstrated that J-integral concepts can accurately predict the fracture response for full-scale cracked structures manufactured from Type 304 stainless steel.

  18. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research.

    PubMed

    Kornum, Birgitte R; Knudsen, Gitte M

    2011-01-01

    Within neuroscience and biobehavioral research, the pig (Sus scrofus) is increasingly being acknowledged as a valuable large animal species. Compared to the rodent brain, the pig brain more closely resembles the human brain in terms of both anatomy and biochemistry, which associates the pig with a higher translational value. Several brain disorders have been fully or partially modeled in the pig and this has further spurred an interest in having access to behavioral tasks for pigs, and in particular to cognitive tasks. Cognitive testing of pigs has been conducted for several years by a small group of farm animal welfare researchers, but it has only recently received interest in the wider neuroscience community. Several behavioral tasks have successfully been adapted to the pig, and valuable results have been produced. However, most tasks have only been established at a single research facility, and would benefit from further validation. This review presents the cognitive tasks that have been developed for pigs, their validation, and their current use.

  19. Serosurvey of leptospirosis in feral hogs (Sus scrofa) in Florida.

    PubMed

    Chatfield, Jenifer; Milleson, Michael; Stoddard, Robyn; Bui, Duy M; Galloway, Renee

    2013-06-01

    Leptospira is a global pathogen of emerging public health importance in both developing and industrialized nations and can infect almost all mammalian species, including humans. As suburbanization and the popularity of outdoor recreational activities increases, so do human-wildlife and companion animal-wildlife interfaces. Florida offers a tropical climate favorable for outdoor activities and a semirural landscape that sustains an abundant feral hog population. Because no survey ofleptospirosis in feral hogs (Sus scrofa) in Florida has been published to our knowledge, we sought to establish preliminary seroprevalence ofleptospirosis exposure in feral hogs in Florida. Blood samples were collected opportunistically from 158 male and 166 female feral hogs taken at managed hunts and by permitted trappers in the northern, central, and southern regions of Florida. Samples were then analyzed using the microscopic agglutination test (MAT) for antibody titers to 20 Leptospira serovars representing 17 serogroups. A titer of > 1:100 was considered positive; 33% (107/324 total samples) were positive to at least one serovar, and 46% of those were positive to multiple serovars. Antibodies to L. interrogans serovar Bratislava strain Jez Bratislava (serogroup Australis) was the most common, with 18% (58/324) testing positive for antibodies. These initial data indicate that there is a significant possibility of feral hogs having a larger role in the complex etiology of leptospirosis in Florida than historically estimated and that further investigation is warranted.

  20. Le matérialisme scientifique

    NASA Astrophysics Data System (ADS)

    Meunier, Jean-François

    2004-03-01

    De nos jours, il arrive quotidiennement aux grands hommes d'avoir à fréquenter d'ignorants mortels épris d'une conviction maladive que la science est la grande responsable de tous les maux du monde. Évidemment sans physique atomique, il n'y aurait pas eu d'Hiroshima et sans révolution industrielle, pas de pollution et etc. Cependant, ces accusations envers le progrès technique sont tout à fait injustes, irréfléchies et, j'irai même jusqu'à dire, irresponsables, puisque le calcul, i.e. la planification, même la plus élémentaire, est ce qui caractérise le mieux, pragmatiquement, la société humaine. À mon avis, les problèmes sociaux tireraient plutôt leur origine de sciences sociales irréalistes, qui, concrètment, inspireraient ou serviraient d'alibis à ceux qui détiennent véritablement le pouvoir. Dans cet article, je tenterai donc de démontrer la meilleure véracité et efficacité du matérialisme scientifique. Cette doctrine, dont Mario Bunge est le plus illustre représentant, s'appuy sur les résultats théoriques et expérimentaux des sciences factuelles ainsi que sur l'exactitude logique des mathématiques, utilisées ici comme langage universel de l'expression des idées. Cette conception philosophique qui s'inspire principalement du modèle des théories physiques, stipule que les réalités sociales sont, comme tout autre réalité, matérielles, mathématisables et représentables comme des systèmes en interaction. En fait, le modèle des physiciens ayant historiquement fait ses preuves en matière de testabilité et de cohérence interne est proposé d'être appliquer aux sciences sociales, aujourd'hui scindées des sciences dites pures sous l'inspiration des pseudo penseurs néo-kantiens, phénoménologiques et post-moderne. Cette nouvelle approche permettrait ainsi d'évoluer plus exactement vers une compréhension des bases sociales et biologiques du comportement humain afin de développer une éthique sans cesse plus r

  1. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2003-09-01

    Système solaire poussiéreux; Combien d'étoiles dans le ciel?; Distance d'un pulsar; Planètes poussières et métaux; Un amateur belge bat les professionnels; Matière sombre; Supernova asymétrique; Anneau liégeois; Amas globulaires; Amas globulaires vagabonds; Baptême de satellites; Champ de gravité terrestre; Début de l'univers; XMM et Geminga; Carte neutrinos du ciel; Galaxies et trous noirs; Univers X; SMART-1: signal de départ pour l'aventure lunaire; Les saisons de Pluton; Planète dans M4; Rotation des pulsars; Un jumeau de Jupiter?; Le satellite ISO; Mars Express~:dernier clin d'oeil à la Terre; Waterworld: une réalité?

  2. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-06-01

    Une binaire remarquable; Collision de galaxies; La nébuleuse planétaire C1295; ALMA (suite); Couple massif; Astéroïdes lointains; L’eau de Jupiter; Occultation par Pluton; Super-Terres; Première image d’une planète massive autour d’une étoile double; Tempête au pôle de Saturne

  3. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-06-01

    Loi tchèque sur la pollution lumineuse; XTE J0929-314; Futurs amas de galaxies; Palomar 5; La météo des naines brunes; Trous noirs et galaxies elliptiques; Europe; 2MASS; Mars; Io; Matière sombre; Un objet très froid; Les oscillations stellaires; Un système lanétaire en formation; Binaire serrée; Satellites de Jupiter; Mars sous la loupe; Le Hubble nouveau

  4. Les Troubles Respiratoires Chez Le Brule

    PubMed Central

    Fassi Fihri, J.; Ezzoubi, M.; Boukind, E.H.

    2010-01-01

    Summary A travers une revue de la littérature, cet article se propose d'exposer les particularités des troubles respiratoires chez le brûlé. Ces troubles sont liés à un mécanisme direct, lorsque l'arbre respiratoire est lésé par le transfert d'énergie thermique du à la brûlure et/ou par un mécanisme indirect, lorsque la fonction respiratoire et ventilatoire du poumon est perturbée par les phénomènes loco-régionaux ou généraux du brûlé. Ces troubles respiratoires sont aggravés par l'inhalation des gaz contenus dans la fumée d'incendie. Le diagnostic de ces troubles est clinique et paraclinique. Il doit être précoce et continu. Les patients nécessitent de différents moyens thérapeutiques tels que l'oxygénothérapie, la libération des voies respiratoires, l'amélioration de la mécanique ventilatoire et de la fonction respiratoire, l'antibiothérapie ou la chirurgie des séquelles. Cette prise en charge doit nécessairement être multidisciplinaire. PMID:21991224

  5. Advanced Laparoscopy Training for General Surgery Residents Using a Pig Model (Sus scrofa domestica)

    DTIC Science & Technology

    2010-01-01

    Surgery Residents Using a Pig Model ( Sus scrofa domestica) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Robert...Protocol Title: "Advanced Laparoscopy Training for General Surgery Residents Using a Pig Model ( Sus scrofa domestica)" 3. Principal Investigator (PI

  6. Resident Training in General Surgery Using a Pig Model (Sus scrofa domestica)

    DTIC Science & Technology

    2010-01-01

    Using a Pig Model ( Sus scrofa domestica) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Robert Cromer 5d. PROJECT...Training in General Surgery Using a Pig Model ( Sus scrofa domestica)" 3. Principal Investigator (PI): Maj Robert Cromer, USAF, MC, Staff General Surgeon, 81

  7. Comparative Testing of Hemostatic Dressing in a Large Animal Model (Sus Scorofa) with Severe hepatic Injuries

    DTIC Science & Technology

    2013-12-02

    hemostatic dressings in a large animal model (Sus scrofa ) with severe hepatic injuries PRINCIPAL INVESTIGATOR (PI) / TRAINING COORDINATOR (TC): Capt...to Date Sus scrofa 36 18 18 Note. Many fewer animals than approved were used because one of the original treatment groups (Lypressin- soaked gauze

  8. Le déficit immunitaire humoral: mieux le connaître pour mieux le prendre en charge

    PubMed Central

    El Bakkouri, Jalila; Aadam, Zahra; Ailal, Fatima; Alj, Hanane Salih; Bousfiha, Ahmed Aziz

    2014-01-01

    Les déficits immunitaires humoraux (DIH) sont des maladies hétérogènes allant des formes asymptomatiques rencontrés lors des déficits sélectifs en immunoglobulines A (IgA) et en sous-classes d'IgG aux formes graves des agammaglobulinémies congénitales. Les patients atteints de DIH présentent souvent des infections ORL ou des voies respiratoires récidivantes ou sévères. Ces patients peuvent présenter un certain nombre de complications non infectieuses, telles que des manifestations auto-immunes et des entéropathies, qui pourraient être le seul symptôme clinique révélateur. Les formes sévères des DIH sont facilement diagnostiquées grâce au dosage des IgG totaux, des IgA et des IgM. La thérapie substitutive par les immunoglobulines reste le traitement de choix chez ces patients. PMID:25489366

  9. Le Chatelier's principle with multiple relaxation channels

    NASA Astrophysics Data System (ADS)

    Gilmore, R.; Levine, R. D.

    1986-05-01

    Le Chatelier's principle is discussed within the constrained variational approach to thermodynamics. The formulation is general enough to encompass systems not in thermal (or chemical) equilibrium. Particular attention is given to systems with multiple constraints which can be relaxed. The moderation of the initial perturbation increases as additional constraints are removed. This result is studied in particular when the (coupled) relaxation channels have widely different time scales. A series of inequalities is derived which describes the successive moderation as each successive relaxation channel opens up. These inequalities are interpreted within the metric-geometry representation of thermodynamics.

  10. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-04-01

    Cartographie d’une naine brune; 2006DP14; Anatomie d’un astéroïde; L’astéroïde P/2013 R3; Formation des planètes; Planètes Kepler; Bêta Pictoris; Cratère Mojave; Les astéroïdes de la ceinture principale; Planète X; Mercure et la gravitation; Gloire sur Vénus; Galaxies elliptiques massives; Cas A; SN 2014J et les supernovae Ia; Le Grand Nuage de Magellan; Nébuleuse d’Andromède; ESO 137-001

  11. Le synovialosarcome primitif de la verge

    PubMed Central

    Saadi, Ahmed; Bouzouita, Abderrazak; Kerkeni, Walid; Ayed, Haroun; Znaidi, Nadia Sabbegh; Ben Miled, Aicha; Messai, Taha; Cherif, Mohamed; Ben Slama, Riadh; Rammeh, Soumaya; Mnif, Najla; Maalej, Mongi; Derouiche, Amine; Chebil, Mohamed

    2017-01-01

    Résumé Le synovialosarcome représente un sous-type rare des sarcomes des tissus mous. Son apparition au niveau de la verge est exceptionnelle et seulement deux cas ont été rapportés dans la littérature auparavant. Nous rapportons un nouveau cas de synovialosarcome de la verge chez un jeune patient de 27 ans, en essayant par l’entremise d’une revue de la littérature de discuter des aspects radiologiques, histologiques, immunohistochimiques, thérapeutiques et pronostiques de cette tumeur exceptionnelle. PMID:28163814

  12. [Analysis of the progressivity of Brazilian Unified National Health System (SUS) financing].

    PubMed

    Ugá, Maria Alicia Domínguez; Santos, Isabela Soares

    2006-08-01

    This article analyzes the level of progressivity in taxes financing the Brazilian Unified National Health System (SUS). Distribution of the tax burden financing the SUS was calculated using micro-data from the Household Budgets Survey, 2002-2003. The Kakwani index, which shows a tax system's level of progressivity, was calculated. The Kakwani index of public financing was -0.008, and SUS financing was nearly proportional to income. From a social justice perspective this is highly undesirable in a society like Brazil, with a Gini index of 0.57. The system should be clearly progressive in order to counterbalance the country's extreme income concentration.

  13. Lele de l’omalizumab dans le traitement de l’asthme allergique grave

    PubMed Central

    Chapman, Kenneth R; Cartier, André; Hébert, Jacques; McIvor, R Andrew; Schellenberg, R Robert

    2006-01-01

    CONTEXTE : Un nouveau traitement anti-immunoglobuline E (anti-IgE) contre l’asthme, l’omalizumab, a été approuvé au Canada. OBJECTIF : Passer en revue les données fondamentales et cliniques sur l’omalizumab et examiner lele possible de ce médicament dans la prise en charge de l’asthme au Canada. MÉTHODOLOGIE : Une recherche documentaire a été effectuée dans MEDLINE afin de repérer les études menées de 1960 à 2006 sur l’omalizumab. La recherche a également porté sur les résumés de réunions scientifiques récentes dans le domaine des maladies respiratoires et des allergies; par ailleurs, toute donnée non publiée a été demandée au fabricant. Après avoir revu et résumé les données, un comité mixte constitué de spécialistes des maladies respiratoires et des allergies a rédigé un ensemble de recommandations relatives à l’utilisation de l’omalizumab. RÉSULTATS : L’omalizumab est un anticorps monoclonal humanisé qui se lie au domaine C epsilon 3 de la molécule d’IgE pour former des complexes immuns solubles qui sont éliminés par le système réticulo-endothélial. L’administration d’injections sous-cutanées espacées de deux ou de quatre semaines à la dose recommandée entraîne une diminution rapide des taux d’IgE circulantes libres. Lors de deux essais cliniques de phase III menés auprès de 1 405 adultes et adolescents atteints d’asthme modéré à grave qui recevaient des doses moyennes stables de corticostéroïdes en inhalation (CSI), l’omalizumab a diminué les taux d’exacerbation par rapport au placebo et a été associé à une amélioration des symptômes ainsi qu’à une épargne plus importante des corticostéroïdes. Dans un essai mené auprès de 419 patients atteints d’asthme grave non maîtrisé malgré l’utilisation de doses élevées de CSI et de la prise concomitante d’agonistes bêta-2 à action prolongée, les exacerbations graves étaient de 50 % moins fréquentes chez

  14. [The construction of the 'SUS problem' in the newspaper Folha de S. Paulo].

    PubMed

    Silva, Gabriela Martins; Rasera, Emerson Fernando

    2014-01-01

    The article examines the process of discursive construction of the 'SUS problem' in reports published in the newspaper Folha de S. Paulo in 2008. Through an online search of the Folha archives, 667 news items were selected and then studied from the perspectives of critical discourse analysis and contributions from social constructionism. In methodological terms, at the text practice level of analysis, the investigation sought to determine what linguistic resources had been used to construct the SUS problem. At the discursive practice level of analysis, it further explored how the newspaper medium and the journalistic style influenced the production of these meanings. The article concludes that as this production constructs the SUS problem, it fosters a limited, negative view of the the Sistema Único de Saúde (Unified Healthcare System, or SUS) based on mistrust and on the notion that it is impossible to improve the system.

  15. Antisense suppression of cucumber (Cucumis sativus L.) sucrose synthase 3 (CsSUS3) reduces hypoxic stress tolerance.

    PubMed

    Wang, Hongyun; Sui, Xiaolei; Guo, Jinju; Wang, Zhenyu; Cheng, Jintao; Ma, Si; Li, Xiang; Zhang, Zhenxian

    2014-03-01

    Sucrose synthase (SUS; EC 2.4.1.13) plays important roles in sugar metabolism and abiotic stress response. But the genes encoding SUS in cucumber (Cucumis sativus L.) have not been well studied. Here, we isolated four cucumber sucrose synthase genes (CsSUS). Among them, CsSUS3, which highly expressed in the roots, was chosen for further study. Immunolocalization and subcellular localization analysis indicated that CsSUS3 localized in the cytosol and the plasma membrane, and mainly existed in the companion cells of phloem in the roots. When suffering hypoxia stress from flooding, CsSUS3 expression and SUS activity in roots increased, especially in the lateral roots; moreover, the soluble SUS activity increased clearly, but the membrane fraction hardly changed. Compared with the wild-type cucumbers, the transgenic lines with antisense expression of CsSUS3 were more sensitive to flooding. After 6 d of flooding, the SUS activity, soluble sugar and uridine 5'-diphosphate glucose (UDPG) content and the ratio of ATP/ADP in the roots of transgenic plants were significantly lower than that in wild-type plants. Moreover, the transgenic lines grew more slowly with more yellow necrosis in the leaves. These findings suggested CsSUS3 participated in resisting hypoxic stress. Furthermore, the mechanism of CsSUS3 in resisting hypoxic stress was also discussed.

  16. Second Language Acquisition of the Chinese Particle "Le."

    ERIC Educational Resources Information Center

    Wen, Xiaohong

    1995-01-01

    This study investigated 14 English speakers' interlanguage constructions using the Chinese perfective aspect and the sentence-final modal particle. The results show that although the surface forms of the perfective aspect "-le" and the sentence-final "le" are identical, they are learned differently, with the perfective aspect…

  17. Insights: Simple Models for Teaching Equilibrium and Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Russell, Joan M.

    1988-01-01

    Presents three models that have been effective for teaching chemical equilibrium and Le Chatelier's principle: (1) the liquid transfer model, (2) the fish model, and (3) the teeter-totter model. Explains each model and its relation to Le Chatelier's principle. (MVL)

  18. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2006-11-01

    Glace et éclairs; Astéroïdes; Pluton; Avatars et avanie d'une petite planète (Xena, Eris); Nuage d'éthane sur Titan; Lacs de Titan; La NASA scrute Mars; Les express Mars et Venus; Cydonia, le visage sur Mars; Transit d'Ariel; Lune; Gonflée, la planète; Terres, terres!; Une planète extrasolaire aurait abrité de l'eau liquide; Des planètes au centre de la Voie Lactée; Anatomie d'un disque protoplanétaire; CHRX73 et pseudo-planète; Systèmes étranges; Premières galaxies; Voie Lactée; Neutrinos; RCW 86

  19. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2009-10-01

    Dunes de Titan; Lac Ontario; Titan; Anneaux de Saturne; Jupiter; Mars; Rotation de Saturne; Valles Marineris; Méthane martien; Epsilon Aurigae; Glycine cométaire; HD 87643; Pluton; Bételgeuse; Site astronomique; Andromède cannibale; Attaque de trou noir; BD+44 493; Formation d'étoiles; Gaz manquant; LIGO; M87; Naine blanche; Galaxie satellite; Galaxies naines sphéroïdales; Galaxies trapues; Cygnus X-1; L'avenir de la Voie Lactée; Naphtaline cosmique; Premiers trous noirs; Coup de foudre; Effet de serre; Glace lunaire; Impacts et extinctions; Exoplanètes rétrogrades; Kepler; Planète chaude; Collision planétaire; Disques dans le vent; Exoplanètes; Formation des planètes; Taches et transits

  20. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  1. SusHi Bento: Beyond NNLO and the heavy- top limit

    NASA Astrophysics Data System (ADS)

    Harlander, Robert V.; Liebler, Stefan; Mantler, Hendrik

    2017-03-01

    Version 1.6.0 of the code SusHi is presented. Concerning inclusive CP-even Higgs production in gluon fusion, the following new features with respect to previous versions have been implemented: expansion of the partonic cross section in the soft limit, i.e. around x = MH2 / s ˆ → 1; N3LO QCD corrections in terms of the soft expansion; top-quark mass suppressed terms through NNLO; matching to the cross section at x → 0 through N3LO. For CP-even and -odd scalars, an efficient evaluation of the renormalization-scale dependence is included, and effects of dimension-5 operators can be studied, which we demonstrate for the SM Higgs boson and for a CP-even scalar with a mass of 750 GeV. In addition, as a generalization of the previously available b b ¯ → H cross section, SusHi_1.6.0 provides the cross section for charged and neutral Higgs production in the annihilation of arbitrary heavy quarks. At fixed order in perturbation theory, SusHi thus allows to obtain Higgs cross-section predictions in different models to the highest precision known today. For the SM Higgs boson of MH = 125 GeV, SusHi yields 48.28 pb for the gluon-fusion cross section at the LHC at 13 TeV. Simultaneously, SusHi provides the renormalization-scale uncertainty of ± 1 . 97 pb.

  2. L’apport de la dermoscopie dans le carcinome basosquameux

    PubMed Central

    Elmahi, Hakima; Lahlou, Asmae; Baybay, Hanane; Gallouj, Salim; Mernissi, Fatima Zahra; Reggad, Fatima Zahra; Harmouch, Taoufik

    2016-01-01

    Le carcinome basosquameux (CBS) est un cancer cutané rare qui présente des zones de carcinome basocellulaire (CBC) et de carcinome épidermoïde (SCC) et une zone de transition entre elles. Cependant, les caractéristiques dermoscopiques du BSC ne sont pas bien décrites dans la littérature, sauf deux études. Le but du présent cas était de mieux identifier et clarifier la contribution de la dermoscopie dans le diagnostic du BSC, malgré que la confirmation reste toujours histologique. PMID:28293368

  3. Les Hemorragies Gastroduodenales de Stress Chez le Brule Grave

    PubMed Central

    Siah, S.; Fouadi, F.E.; Ababou, K.; Nassim Sabah, T.; Ihrai, I.

    2008-01-01

    Summary Les Auteurs rapportent trois observations d'hémorragies gastroduodénales de stress chez le brûlé grave. Ils rappellent l'importance des mesures thérapeutiques qui doivent être prises chez le brûlé grave, comme le traitement du choc, du sepsis, des plaies et de la douleur, la nutrition entérale précoce et l'oxygénothérapie. Tout cela permet de réduire les facteurs de risque de survenue d'une hémorragie gastroduodénale de stress. PMID:21991137

  4. Automated Verification of Design Patterns with LePUS3

    NASA Technical Reports Server (NTRS)

    Nicholson, Jonathan; Gasparis, Epameinondas; Eden, Ammon H.; Kazman, Rick

    2009-01-01

    Specification and [visual] modelling languages are expected to combine strong abstraction mechanisms with rigour, scalability, and parsimony. LePUS3 is a visual, object-oriented design description language axiomatized in a decidable subset of the first-order predicate logic. We demonstrate how LePUS3 is used to formally specify a structural design pattern and prove ( verify ) whether any JavaTM 1.4 program satisfies that specification. We also show how LePUS3 specifications (charts) are composed and how they are verified fully automatically in the Two-Tier Programming Toolkit.

  5. Le point sur les amas de galaxies

    NASA Astrophysics Data System (ADS)

    Pierre, M.

    galaxies jouent donc un rôle de premier plan dans toute étude cosmologique et par conséquent, sont indispensables à notre compréhension globale de l'univers. Dans l'introduction générale, nous détaillons cet aspect fondamental en montrant comment l'étude des amas peut contribuer à contraindre les scénarios cosmologiques. Une fois le contexte scientifique délimité, les chapitres suivants s'attachent à présenter les diverses propriétés des amas et leur évolution cosmique observée dans diverses longueurs d'onde principalement dans les domaines visible (galaxies), X (gaz) et radio (gaz et particules). Nous verrons que l'étude détaillée d'un amas implique celle de l'interaction entre ses différentes composantes et est un passage obligé pour remonter au paramètre ultime (ou premier) qu'est sa masse. Loin d'être un détour ennuyeux, ceci sera l'occasion d'aborder des phénomènes physiques extrêmement variés tel l'aspect multi-phases du milieu intra-amas, les sursauts de formation d'étoiles et l'évolution morphologique des galaxies capturées par les amas, ou bien encore, l'interaction entre le plasma intra-amas et les particules relativistes accélérées lors de la fusion entre deux amas. Bien sûr, pour chaque longueur d'onde, nous ne manquerons pas de décrire simplement les techniques d'observation et d'analyse mises en oeuvre ; celles-ci sont particulièrement intéressantes dans le cas de l'instrumentation spatiale. Nous terminerons en présentant des projets d'observatoires pour l'horizon 2010 et leur impact prévu sur l'étude des amas de galaxies.

  6. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2007-09-01

    Anions interstellaires; S Orionis; Altaîr; Courants stellaires; Etoiles jeunes; 2MASSW J1207334-393254; Alpha Andromède; Etoiles à neutrons (1); LH54-425; AGNs invisibles; Deux supernovae; Les GRBs seon Swift; Peser les trous noirs; Formation de trous noirs; Trou noir; ondes gravitationnelles : Virgo entre dans sa phase d'exploitation scientifique; Amas de galaxies actifs; Amas de galaxies; Galaxies actives d'amas; L'univers statique: le retour; Macho; Exoplanètes; Exoplanètes habitables?; Exoplanètes habitables? (suite); Une année d'un an; Une année de 31 heures; Valse des Jupiters; Disque de HD 15115; Impact majeur; Planètes isolées; Super-Jupiter; Impact et mini-extinction; L'effet Pioneer; Toungouska; Spéléo martienne; Autres lunes dactives; Encelade; Hypérion; Pluton dépassé; Satellites d'Uranus; Titan

  7. Some Aspects of the Teaching of "-Guo" and "-Le"

    ERIC Educational Resources Information Center

    Ma, Jing-heng S.

    1977-01-01

    This paper examines the two markers of Mandarin Chinese, "-guo" and "-le," and focuses primarily on areas of difficulty that the non-native speaker may encounter due to confusion of these markers. (CHK)

  8. Lymphoscintigraphy (LS) in lymphedema (LE) of the extremities

    SciTech Connect

    Gloviczki, P.; Vaqueiro, M.; Fisher, J.; Schirger, A.; Dewanjee, M.K.; Hollier, L.H.; Wahner, H.W.

    1985-05-01

    Twenty-two patients with primary and secondary LE and one with lipedema had LS using 0.4-0.6 mCi of Tc-99mSb2Sb3 subcutaneous at the second interdigital space. Three had excisional surgery, in four patients lympho-venous anastomosis (LVA) was attempted following LS. Results are presented in this paper. This study concludes that LS is a noninvasive method without side effects that visualizes the pattern of the lymphatic system in LE. If lymph channels were seen, LVA could be performed. LS seems adequate for patient selection and follow-up after LVA. It differentiated LE from lipedema. Image patterns or quantitative studies could not differentiate between primary and secondary LE.

  9. Microscopic Description of Le Châtelier's Principle

    NASA Astrophysics Data System (ADS)

    Novak, Igor

    2005-08-01

    The analysis based on microscopic descriptors (energy levels and their populations) is given that provides visualization of free energies and conceptual rationalization of Le Châtelier's principle. The misconception "nature favors equilibrium" is highlighted.

  10. CIM - A Manufacturing Paradigm (Le CIM - Un Nouveau Modele Industriel),

    DTIC Science & Technology

    1986-07-01

    fait la plupart des entreprises , ont affind le module de "Rgvolution industrielle". Nous vivons A l’poque du spdcialiste. Toutefois, le modale de sp...program will serve as an umbrella under which specific projects are planned, financed , managed, and imple- mented. Well defined corporate goals must be...assets. Through an integration of financing strategies an enterprise can focus on capital investment in shared, value-added assets such as databases

  11. Searching the animal psyche with Charles Le Brun.

    PubMed

    Cohen, Sarah R

    2010-07-01

    Around 1670 the French court painter and Academician Charles Le Brun produced a series of drawings featuring naturalistic animal heads, as well as imaginary heads in which he refashioned various nonhuman animal species to make humanoid physiognomies. What were the purpose and significance of these unusual works? I argue that they show Le Brun's interest in what we today would call animal psychology: focusing upon the sensory organs and their connections with the animal's brain, Le Brun studied his animals as conscious protagonists of the natural realm. One source that may have served him in this project was Marin Cureau de La Chambre's De la Connoissance des bestes of 1645, in which the physician argued that animals possess a conscious soul grounded in the senses. However, Le Brun's animal-humans have no clear place in the artist's taxonomy--nor, indeed, in any seventeenth-century understandings of species. It is rather John Locke, at his most skeptical, who offers the best parallel in the realm of natural philosophy to Le Brun's unsettling animal-humans. Probably without meaning to, Le Brun demonstrated through his eerie, boundary-crossing creatures the limits of visual classification.

  12. Transmaxillary Sinus Approach for Le Fort II Osteotomy

    PubMed Central

    Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-01-01

    Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy. PMID:27014548

  13. Le Soleil et ses relations avec la Terre

    NASA Astrophysics Data System (ADS)

    Lang, Kenneth; Heidmann, M.

    C'est le 2e livre de K. Lang publié en français, considéré comme texte complementaire au célèbre Vagabonds de l'Espace qui avait gagné en 1994 le prix du livre d'astronomie en France. Maintenant l'auteur se concentre sur le système le plus élémentaire: l'étoile et son planète, et choisit celui qui est le plus intéressant pour nous: le Soleil et la Terre. Il a accumulé les observations terrestres et les plus récentes effectuées par des observatoires spatiales, et ceux des météorologues et géophysiciens, et nous présente un panorama fascinant du Soleil et ses relations avec la Terre. C'est la physique qui a les conséquences les plus fondamentales aux événements qui influencent notre environment, notre vie et même la condition humaine y inclu les arts et la litérature.

  14. Le Point sur la Pharmacologie des Agents Anesthesiques Chez le Brule Grave

    PubMed Central

    Siah, S.; Ababou, K.; Benziane, H.; El Jaoudi; Bensghir, M.; Bakali, H.; El Wali, A.; Ihrai, I.; Drissi, N.K.

    2008-01-01

    Summary La pharmacologie des agents anesthésiques chez le brûlé est variable et imprévisible. Dans les premières 48 h, il y a une hypovolémie avec chute du débit cardiaque et des fuites plasmatiques. Après 48 h, il y a une hypervolémie avec augmentation du débit cardiaque, hypermétabolisme et la clearance des médicaments est augmentée. Parmi les facteurs de déséquilibre, on retrouve les variations des protéines plasmatiques. Deux protéines sont importantes chez le brûlé grave : l'albumine et l'alpha 1- glycoprotéine. Leur taux varie beaucoup au cours de l'évolution de la brûlure. Les agents anesthésiques dont la liaison avec ces deux protéines est prédominante verront leur pharmacocinétique modifiée. L'anesthésiste-réanimateur du service des brûlés va maîtriser ces notions pharmacologiques pour utiliser à bon escient les agents anesthésiques. PMID:21991108

  15. Does Glucagon Improve Survival in a Porcine (Sus Scrofa) of Adult Asphyxial Cardiac Arrest in Addition to Standard Epinephrine Therapy?

    DTIC Science & Technology

    2012-01-17

    UDIIILI: oa. I..UN I ItA!.. I NUMDI:It Does Glucagon improve survival in a porcine (Sus Scrofa ) of adult asphyxial cardiac arrest in addition to...EXPIRATION DATE: 25 Mar 13 PROTOCOL TITLE: Does Glucagon Improve Survival in a Porcine (Sus scrofa ) Model of Adult Asphyxial Cardiac Arrest in Addition...Additions: Deletions: 2 Protocol No: A-2007-03 Protocol Title: Does Glucagon Improve Survival in a Porcine (Sus scrofa ) Model of Adult Asphyxial

  16. Etude de la transition tribologique entre le fretting et le meso-fretting pour des materiaux de contact electrique

    NASA Astrophysics Data System (ADS)

    Gagnon, Daniel

    Dans les installations electriques, les contacts sont toujours soumis a des contraintes alternees ou a des micro-deplacements. Il en resulte une corrosion par fretting, phenomene defini comme un type de deterioration de la surface qui se produit lorsque deux materiaux en contact sont soumis a des mouvements microscopiques d'oscillations de tres faible amplitude (0 a 100 mum). Ceci a pour effet de provoquer une degradation de la resistance de contact et une interruption du passage du courant. Ce phenomene a des repercussions considerables sur le plan pratique puisque les micro-deplacements de pieces en contact peuvent etre causes par la dilatation thermique differentielle des metaux, par des vibrations mecaniques, par la relaxation des contraintes ou par l'echauffement des contacts lorsqu'on interrompt et retablit le courant. Nous avons donc dans le cadre de cette these etudie plusieurs aspects du fretting (0--100 mum) et du meso-fretting (100 a 1000 mum) pour differents materiaux de contact electrique. Des travaux experimentaux ont ete realises a partir de deux montages reproduisant divers aspects de la degradation par le fretting. Un premier montage de fretting de type bille-plaque a ete entierement developpe a l'ETS et un second montage, de type fil-plaque a ete utilise en collaboration avec Hydro Quebec IREQ a Varennes. Plusieurs techniques de mesures et d'analyse relevant tant du domaine de la mecanique du contact que de la metallurgie ont ete utilisees pour traiter les resultats. L'influence du courant sur le taux d'usure et la force de friction a ete examinee pour divers materiaux de contacts. Des essais de fatigue thermique et electrique ont ete realises sur divers materiaux et lubrifiants de contact. Il a ete demontre que pour le domaine entre 100 mum et 1000 mum, le taux d'usure n'est pas le meme de 0 a 100 mum et au dela de 1000 mum. La plupart des materiaux evalues montrent un stade de comportement intermediaire dont le debut se situe entre 100 mum et

  17. Transgenic switchgrass (Panicum virgatum L.) biomass is increased by overexpression of switchgrass sucrose synthase (PvSUS1).

    PubMed

    Poovaiah, Charleson R; Mazarei, Mitra; Decker, Stephen R; Turner, Geoffrey B; Sykes, Robert W; Davis, Mark F; Stewart, C Neal

    2015-04-01

    Sucrose synthase (SUS) converts sucrose and uridine di-phosphate (UDP) into UDP-glucose and fructose. UDP-glucose is used by the cellulose synthase to produce cellulose for cell wall biosynthesis. For lignocellulosic feedstocks such as switchgrass, the manipulation of cell walls to decrease lignin content is needed to reduce recalcitrance of conversion of biomass into biofuels. Of perhaps equal importance for bioenergy feedstocks is increasing biomass. Four SUS genes were identified in switchgrass. Each gene contained 14 or 15 introns. PvSUS1 was expressed ubiquitously in the tissues tested. PvSUS2 and PvSUS6 were highly expressed in internodes and roots, respectively. PvSUS4 was expressed in low levels in the tissues tested. Transgenic switchgrass plants overexpressing PvSUS1 had increases in plant height by up to 37%, biomass by up to 13.6%, and tiller number by up to 79% compared to control plants. The lignin content was increased in all lines, while the sugar release efficiency was decreased in PvSUS1-overexpressing transgenic switchgrass plants. For switchgrass and other bioenergy feedstocks, the overexpression of SUS1 genes might be a feasible strategy to increase both plant biomass and cellulose content, and to stack with other genes to increase biofuel production per land area cultivated.

  18. Comparison of methods of extracting messenger Ribonucleic Acid from ejaculated Porcine (Sus Scrofa) Spermatozoa

    Technology Transfer Automated Retrieval System (TEKTRAN)

    H. D. Guthrie, G.R. Welch, and L. A. Blomberg. Comparison of Methods of Extracting Messenger Ribonucleic Acid from Ejaculated Porcine (Sus Scrofa) Spermatozoa. Biotechnology and Germplasm Laboratory, Agricultural Research Service U. S. Department of Agriculture, Beltsville, MD 20705 The purpos...

  19. A Study of Instructional Faculty Salaries at USF, SUS and National Peers

    ERIC Educational Resources Information Center

    Micceri, Theodore

    2010-01-01

    This study investigates 10-year trends in instructional faculty salaries by sex and rank for USF, five SUS Peers (UF, FSU, FIU, UCF, FAU) and eight National Peers (North Carolina State, Alabama-Birmingham, Illinois-Chicago, California-Irvine, SUNY-Stony Brook, SUNY-Buffalo, Cincinnati, Rutgers). Methods: Historical instructional faculty salary…

  20. 2013 Higher Education Summit/SUS Data Workshop Proceedings. Session: IRM Data Workshop

    ERIC Educational Resources Information Center

    Board of Governors, State University System of Florida, 2013

    2013-01-01

    Information Resource Management--State University System of Florida (IRM-SUS) is the primary collector and provider of data concerning state universities that is used to make sound education policy decisions. The office provides technical assistance to those using the information, state and federal reporting support, those supplying information,…

  1. Development of nanostructured SUS316L-2%TiC with superior tensile properties

    NASA Astrophysics Data System (ADS)

    Sakamoto, T.; Kurishita, H.; Matsuo, S.; Arakawa, H.; Takahashi, S.; Tsuchida, M.; Kobayashi, S.; Nakai, K.; Terasawa, M.; Yamasaki, T.; Kawai, M.

    2015-11-01

    Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below Md (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90-270 nm, accompanied by TiC precipitates with 20-50 nm in grain interior and 70-110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6-21%, respectively, depending on the heat treatment temperature after rolling at -196 °C.

  2. Texture and phase analysis of deformed SUS304 by using HIPPO

    SciTech Connect

    Takajo, Shigehiro; Vogel, Sven C.

    2016-11-15

    These slides represent the author's research activity at Los Alamos National Laboratory (LANL), which is about texture and phase analysis of deformed SUS304 by using HIPPO. The following topics are covered: diffraction histogram at each sample position, diffraction histogram (all bank data averaged), possiblity of ε-phase, MAUD analysis with including ε-phase.

  3. Absence of bovine tuberculosis in feral swine (Sus scrofa) from the Southern Texas border region

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Free-ranging wildlife, like feral swine (Sus scrofa), harbor a variety of diseases that are infectious to livestock and could negatively impact agricultural production. Information is lacking regarding the exposure and infection rates for bovine tuberculosis (Mycobacterium bovis; bTB), and many othe...

  4. Synthesis of a BSA-Le(x) glycoconjugate and recognition of Le(x) analogues by the anti-Le(x) monoclonal antibody SH1: the identification of a non-cross reactive analogue.

    PubMed

    Wang, Jo-Wen; Asnani, Ari; Auzanneau, France-Isabelle

    2010-10-15

    A Le(x) trisaccharide functionalized with a cysteamine arm was prepared and this synthesis provided additional information on the reactivity of N-acetylglucosamine O-4 acceptors when they are glycosylated with trichloroacetimidate donors activated with excess BF(3)·OEt(2). In turn, this trisaccharide was conjugated to BSA lysine side chains through a squarate-mediated coupling. This BSA-Le(x) glycoconjugate displayed 35 Le(x) haptens per BSA molecule. The relative affinity of the anti-Le(x) monoclonal antibody SH1 for the Le(x) antigen and analogues of Le(x) in which the D-glucosamine, L-fucose or D-galactose residues were replaced with D-glucose, L-rhamnose and D-glucose, respectively, was measured by competitive ELISA experiments. While all analogues were weaker inhibitors than the Le(x) antigen, only the analogue of Le(x) in which the galactose residue was replaced by a glucose unit showed no binding to the SH1 mAb. To confirm that the reduced or loss of recognition of the Le(x) analogues by the anti-Le(x) mAb SH1 did not result from different conformations adopted by the analogues when compared to the native Le(x) antigen, we assessed the conformational behavior of all trisaccharides by a combination of stochastic searches and NMR experiments. Our results showed that, indeed, the analogues adopted the same stacked conformation as that identified for the Le(x) antigen. The identification of a trisaccharide analogue that does not cross-react with Le(x) but still retains the same conformation as Le(x) constitutes the first step to the design of a safe anti-cancer vaccine based on the dimeric Le(x) tumor associated carbohydrate antigen.

  5. Transitions de phase dans le oxyde de yttrium vanadium

    NASA Astrophysics Data System (ADS)

    Roberge, Benoit

    Dans le mémoire qui suit, les ordres structural, magnétiques et orbital dans le YVO3 sont étudiés avec l'aide de la diffraction des rayons X,de la spectroscopie Raman et de la technique de la cavité résonnante hyperfréquence. L'objectif premier consiste à observer l'évolution de ces ordres en fonction de la température. Le mémoire met ensuite en évidence le couplage entre les différents ordres cohabitants dans le YVO3 . Les mesures effectuées par la diffraction des rayons X permettent de mesurer le caractère polycrystallin des échantillons du YVO 3. Une comparaison de nos mesures avec des mesures de diffraction des rayons X faites sur la poudre de YVO3 indique la faible présence de maclage. Les mesures effectuées avec la technique de résonnance hyperfréquence permettent de suivre l'évolution de la constante diélectrique en fonction de la température. Les changements impliquant l'ordre orbital se manifestent de manière évidente dans la constante diélectrique à 200 K et à 77 K. La transition diélectrique détectée à 77 K est une transition de premier ordre. Un couplage entre les propriétés diélectriques et magnétiques est observable à la température de Néel à 114 K. L'effet d'un champ magnétique fixe sur la température de transition de l'ordre orbital survenant à 77 K est également remarquable. Cela indique un couplage magnétodiélectrique démontrant ainsi le caractère multiferroïque du YVO 3. Finalement, l'observation d'un mécanisme de relaxation pouvant être modélisé par le modèle d'Havriliak-Negami est observé en dessous de 77 K. En utilisant le modèle d'Arrhénius et le modèle d'Havriliak-Negami, on peut caractériser le mécanisme avec son énergie d'activation et son temps de relaxation. Les mesures effectuées en spectroscopie Raman permettent de suivre l'évolution de la structure du YVO3 en fonction de la température. Les deux changements structuraux survenant à 200 K et 77 K sont observés. Le

  6. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    Des mesures spectroscopiques effectuees avec un haut rapport signal sur bruit et une bonne resolution ont demontre l'existence de regions perturbees en mouvement dans le vent d'etoiles Wolf-Rayet (WR). L'echantillon d'objets etudies ici comprend 9 etoiles WR couvrant differents sous-types WN et WC. De nombreuses petites structures variables superposees au profil des raies d'emission formees dans le vent stellaire signalent la presence des perturbations. L'etude des variations globales des raies et l'examen des micro-structures individuelles ont permis de decrire plusieurs caracteristiques des perturbations. Entre autres, on observe des correlations significatives entre le niveau de variabilite des raies et certains parametres des etoiles qui confirment que le phenomene de variabilite est intrinseque au vent stellaire. En comparant les changements des vitesses radiales et des largeurs equivalentes des differentes raies d'une meme etoile, on conclut que les regions perturbees ont une etendue finie par rapport a l'enveloppe des etoiles. On peut facilement suivre les structures individuelles sur une periode de temps couvrant ~eq8 heures (et peut etre meme 24 heures) avant qu'elles ne disparaissent. Durant ce temps les structures se deplacent en s'eloignant du centre de la raie. A partir des differents comportements notes lors de l'analyse des variations globales et lors de l'examen des structures individuelles, on propose de representer les perturbations par un modele d'inhomogeneites discretes en expansion dans le vent. On suppose simplement que les inhomogeneites emettent comme le vent global (et absorbent aussi si le vent global montre un profil P Cyg). La superposition du graphique de l'acceleration radiale moyenne des inhomogeneites de WR140 en fonction de leur vitesse radiale et du modele theorique d'inhomogeneites qui suivent la loi generale de vitesse donne un taux d'acceleration lent, avec beta >= 3 pour les inhomogeneites de cette etoile. On obtient, entre

  7. Etude du Photochromisme et de la Photorefractivite dans le Poly

    NASA Astrophysics Data System (ADS)

    Ghailane, Fatima

    1995-11-01

    Nous avons etudie la possibilite d'utiliser un materiau organique, le poly(vinylcarbazole) comme milieu de stockage optique de masse en temps reel. Ce materiau dope aux photochromes presente un potentiel non negligeable pour l'holographie de volume en temps reel. Plusiers cycles, Ecriture-Lecture-Effacement, ont ete enregistres dans cette matrice polymerique avec une resolution assez elevee. Une etude a ete menee afin d'obtenir la valeur des parametres comme l'epaisseur du film et l'intensite d'ecriture pour un angle d'enregistrement theta_{ acute ecriture} donne qui permettent d'obtenir les meilleures efficacites diffractionelles tout en preservant ce milieu de tout effet de fatigue ou de degradation. Ce polymere devient photorefractif une fois melange avec un bon accepteur de charge, le trinitrofluorenone et un bon chromophore non-lineaire, le disperse orange 25. Nous avons etudie experimentalement la conductivite en obscurite et la photoconductivite de ce materiau. Des simulations numeriques ont ete realisees en se basant sur le modele de Poole-Frenkel. Nous avons aussi etudie l'implantation de faisceaux d'ions d'oxygene d'energie 200 keV pour inscrire dans le PVCz un guide d'onde plan a profil d'indice. Une etude ESCA complete cette partie afin de savoir les modifications induites par implementation ionique a l'interieur du film polymerique.

  8. Le syndrome des enfants battus: aspects cliniques et radiologiques

    PubMed Central

    Jlalia, Zied; Znaigui, Talel; Smida, Mahmoud

    2016-01-01

    La maltraitance physique des enfants ou le syndrome des enfants battus est responsable de plus de 75.000 décès par an en France. Ce problème de santé publique reste sous diagnostiqué en Tunisie et dans le monde. Le chemin a été laborieux pour la reconnaissance du syndrome des enfants battus dans certaines sociétés même occidentales. Nous avons voulus exposer ce problème aux praticiens afin qu'il soit mieux diagnostiqué et pris en charge. La maltraitance physique des enfants est appelée à tort syndrome de Silverman qui ne regroupe en fait que les lésions squelettiques chez ces enfants tels que les fractures. Mots clés: Fracture, maltraitance, enfant, neuro-radiologie PMID:27642408

  9. Le Fort I Maxillary Advancement Using Distraction Osteogenesis

    PubMed Central

    Combs, Patrick D.; Harshbarger, Raymond J.

    2014-01-01

    Treatment of maxillary hypoplasia has traditionally involved conventional Le Fort I osteotomies and advancement. Advancements of greater than 10 mm risk significant relapse. This risk is greater in the cleft lip and palate population, whose anatomy and soft tissue scarring from prior procedures contributes to instability of conventional maxillary advancement. Le Fort I advancement with distraction osteogenesis has emerged as viable, stable treatment modality correction of severe maxillary hypoplasia in cleft, syndromic, and noncleft patients. In this article, the authors provide a review of current data and recommendations concerning Le Fort I advancement with distraction osteogenesis. In addition, they outline their technique for treating severe maxillary hypoplasia with distraction osteogenesis using internal devices. PMID:25383054

  10. Le zona ophtalmique: une dermatose rare chez l'enfant

    PubMed Central

    Zakia, Douhi; Meziane, Marieme; Salim, Gallouj; Zahra, Mernissi Fatima

    2015-01-01

    Le zona est dû a une réactivation du virus varicelle-zona (VZV) qui reste quiescent dans les ganglions sensitifs dorsaux après la varicelle. Le zona de l'enfant est rare et particulièrement la forme ophtalmique, qui peut être responsable de complications oculaires graves nécessitant une prise en charge adéquate et précoce. Il est parfois associé à des douleurs post-zostériennes dont le traitement est difficile. L'aciclovir per os administré dans les 72 heures après l’éruption a prouvé son efficacité dans la prévention des complications oculaires. Nous en rapportant un nouveaux cas chez un garçon immunocompétent de 9 ans, sans notion de varicelle antérieure. PMID:26955408

  11. Effect of Harmonic Microstructure on the Corrosion Behavior of SUS304L Austenitic Stainless Steel

    NASA Astrophysics Data System (ADS)

    Rai, Prabhat K.; Shekhar, S.; Nakatani, M.; Ota, M.; Vajpai, S. K.; Ameyama, K.; Mondal, K.

    2016-12-01

    Corrosion behavior of a harmonic structured SUS304L austenitic stainless steel was examined and compared with nonharmonic structured SUS304L stainless steel and conventional 304 stainless steel in 3.5 pct NaCl solution. The study was performed using linear polarization, potentiodynamic polarization, cyclic polarization, and a salt fog exposure test for 30 days. Characterization was accomplished using a scanning electron microscope, an electron probe microanalyzer, and Raman spectroscopy. Improved pitting corrosion resistance was found in the case of the harmonic structured steel as compared to that of the nonharmonic and the conventional 304 stainless steel. Harmonically distributed fine-grained structure, less porosity, and higher fraction of passive α-FeOOH are attributed to the improvement in corrosion resistance of the harmonic structured steel.

  12. The complete mitochondrial genome of European wild boar, Sus scrofa scrofa.

    PubMed

    Hu, Xiao-Di; Yang, Xiao-Tian; Yang, En

    2016-09-01

    In this study, we report the complete mitochondrial genome sequence of the European wild boar, Sus scrofa scrofa for the first time. The genome is found to be 16,770 bp in length and has a base composition of A (34.63%), G (13.38%), C (26.21%), and T (25.78%), indicating that the percentage of A + T (60.41%) was higher than G + C (39.59%). Similar to other pigs, it contains a typically conserved structure including 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 control region (D-loop). Most of the genes were located on the H-strand except for the ND6 gene and eight tRNA genes. The complete mitochondrial genome sequence provided here would add a new genetic resource and new study on the evolution of the genus Sus.

  13. Biochemical and Molecular Characterization of RcSUS1, a Cytosolic Sucrose Synthase Phosphorylated in Vivo at Serine 11 in Developing Castor Oil Seeds*

    PubMed Central

    Fedosejevs, Eric T.; Ying, Sheng; Park, Joonho; Anderson, Erin M.; Mullen, Robert T.; She, Yi-Min; Plaxton, William C.

    2014-01-01

    Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of 32Pi from [γ-32P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes. PMID:25313400

  14. Biochemical and molecular characterization of RcSUS1, a cytosolic sucrose synthase phosphorylated in vivo at serine 11 in developing castor oil seeds.

    PubMed

    Fedosejevs, Eric T; Ying, Sheng; Park, Joonho; Anderson, Erin M; Mullen, Robert T; She, Yi-Min; Plaxton, William C

    2014-11-28

    Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of (32)P(i) from [γ-(32)P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes.

  15. Residual stress and fracture characteristics of zirconia/metal(Ni, SUS304) functionally gradient materials

    SciTech Connect

    Jung, Yeon-Gil; Choi, Sung-Churl; Paik, Un-Gyu

    1995-09-01

    To analyze the residual stress and the fracture behavior of FGMs. disc-type TZP/Ni- and TZP/SUS304-FGM were hot passed, and compared with MM& The continuous interface and the microstructure of FGMs were characterized with EPMA, optical microscopy and SEM. The defect-like cracks in the FGMs induced by the preferential shear stress have been shown to cause fracture. This fact has well corresponded to the analysis of the residual stress distribution by FEM.

  16. The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract

    PubMed Central

    Wengier, Diego; Valsecchi, Isabel; Cabanas, María Laura; Tang, Wei-hua; McCormick, Sheila; Muschietti, Jorge

    2003-01-01

    After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the specific dephosphorylation of LePRK2 suggested that these kinases might interact with signaling molecules in the style extracellular matrix. Here, we show that LePRK1 and LePRK2 can be coimmunoprecipitated from pollen or when expressed together in yeast. In yeast, their association requires LePRK2 kinase activity. In pollen, LePRK1 and LePRK2 are found in an ≈400-kDa protein complex that persists on pollen germination, but this complex is disrupted when pollen is germinated in vitro in the presence of style extract. In yeast, the addition of style extract also disrupts the interaction between LePRK1 and LePRK2. Fractionation of the style extract reveals that the disruption activity is enriched in the 3- to 10-kDa fraction. A component(s) in this fraction also is responsible for the specific dephosphorylation of LePRK2. The style component(s) that dephosphorylates LePRK2 is likely to be a heat-stable peptide that is present in exudate from the style. The generally accepted model of receptor kinase signaling involves binding of a ligand to extracellular domains of receptor kinases and subsequent activation of the signaling pathway by receptor autophosphorylation. In contrast to this typical scenario, we propose that a putative style ligand transduces the signal in pollen tubes by triggering the specific dephosphorylation of LePRK2, followed by dissociation of the LePRK complex. PMID:12748390

  17. Délais de prise en charge des syndromes coronariens aigus avec sus-décalage du segment ST à Ouagadougou et facteurs associés à un allongement de ces délais: étude transversale à propos de 43 cas colligés au CHU-Yalgado Ouédraogo

    PubMed Central

    Yameogo, Nobila Valentin; Samadoulougou, André; Millogo, Georges; Kologo, Koudougou Jonas; Kombassere, Karim; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2012-01-01

    La prise en charge de l'infarctus du myocarde est une course contre la montre et les trois premières heures constituent les « golden hours ». Les objectifs de ce travail étaient de déterminer le délai de prise en charge des infarctus du myocarde du myocarde au Burkina Faso, les facteurs liés à un allongement du délai et le pronostic des patients. Il s'agit d'une étude transversale descriptive menée de Septembre 2010 à Août 2011. Le critère d'inclusion était l'infarctus du myocarde dont le diagnostic était basé sur des critères clinique (douleur angineuse), électrocardiographique (sus-décalage persistant du segment ST dans au moins deux dérivations contiguës du même territoire coronaire, onde Q de nécrose) et biologique (élévation de la troponine). Les informations relatives au délai de prise en charge ont été recueillies: début du premier symptôme, contact avec le premier agent de santé et le cardiologue, nombre de centre de santé consulté avant le transfert en cardiologie, situation géographique des patients, moyen de transport utilisé. Les données ont été analysées grâce au logiciel SPSS version 17. Durant la période d’étude, 43 patients d’âge moyen de 56,51 ± 12,91 ans ont été admis pour infarctus du myocarde. Plus de la moitié des patients (72,0%) habitait Ouagadougou et sa banlieue. Le délai moyen entre le début de la douleur et la consultation dans la première structure sanitaire était de 48 ± 20,8 heures; celui entre le début de la douleur et la réalisation du premier ECG était en moyenne de 8,6 ±4,5 jours. Le délai entre la réalisation de l'ECG et l'admission dans le service de cardiologie était de 4,35 ±4,0 jours [00 heure et 13 jours]. Le délai entre l'admission dans le service de cardiologie et la thrombolyse était de 34 minutes. Enfin le délai entre le début de la douleur et le contact avec le cardiologue était de 9,6±3,5 jours. Il n'y avait pas de différence statiquement

  18. [Integral care, a SUS (Brazilian Unified Health System) guideline for the sanitary surveillance].

    PubMed

    O'Dwyer, Gisele; Reis, Daniela Carla de Souza; da Silva, Luciana Leite Gonçalves

    2010-11-01

    The sanitary surveillance (Visa) performs several practices, on different objects and its actions are guided by principles and guidelines of the SUS. It was done a critical reflection on the interaction conditions of practice in Visa, with a constitutional proposition of the SUS: integral care. The analysis was based on the theory of structuration (Giddens) that considers mobilization of structural resources as dimensions of social interaction, which would justify the legitimacy exercised since the standards. Have been analyzed the following categories: Visa and its insertion within the SUS; the integral care and the Visa; and political impediments. The Visa has been organized by National Health Surveillance Agency. Nowadays it has as sanitary responsibilities, communication with society and health promotion. The proposal of the literature concerning integral care is based on the assistance issue. The organization of the services in the different federative entities is the sense of integral care most adopted by Visa. Political impediments focus on the institutional renewal, on the conflicts of interest arena, on the distance between formulated policies and established practices and gaps concerning work management and the insufficiency of financial support.

  19. [Evaluation of emergency services of the hospitals from the QualiSUS program].

    PubMed

    O'Dwyer, Gisele Oliveira; de Oliveira, Sergio Pacheco; de Seta, Marismary Horsth

    2009-01-01

    The aid lent by the emergency services is the object of this paper, which aims to assess the emergency service of the QualiSUS program. The study is descriptive with the application of a questionnaire to the responsible of the emergency services in eight hospitals. The emergency services were always overcrowded, and the causes pointed were the low resolutivity of basic attention and the precariousness of the hospital network. Contributing to this there is the primary care decreased resolutivity and the precariousness of the hospital network. Six hospitals do not manage the emergency service. The entrance system is not organized and only three hospitals work with risk classification. All of them refer difficulties with internal and external services. The hardest pathologies to refer to other services are the chronicles, neurological and social. The professionals do not have specific qualification and the precariousness job contracts do not contribute neither for the professional's fixation nor for his qualification. Clinical protocols are used by one service. It was noticed the influence of the QualiSUS in the hospitals. The failure of the health services network interferes with the emergency patient's profile. The investment of the QualiSUS cannot be restrained to the hospital. Emergency should be more integrated to the system and hospital. The qualification of human resources is indispensable as well as the bed's regulation.

  20. High temperature joint properties with palladium alloys for SUS316L and Inconel 600

    SciTech Connect

    Izui, Hiroshi; Suezawa, Yoshifumi

    1995-12-31

    Newly developed Pd-Ag-Mn system braze alloys were considered for use in brazing stainless steel SUS316L or Ni-based alloy Inconel 600 for engine applications. Palladium braze alloys were selected because of their oxidation resistance, ductility, relatively high melting points, and lower cost than gold-based braze alloys. The reactions and microstructures were studied in experimental brazed joints between these base metals and the braze alloys. Tensile tests of the joints were carried out at room temperature, 473K, 673K, 873K, and 1,073K. The maximum tensile strengths of the joints brazed with 30Pd-60Ag-10Co at room temperature were 445MPa in the SUS316L joints and 456MPa in the Inconel 600 brazed joints. The SUS316L joints brazed with the braze alloys had tensile strengths of 320MPa to 200MPa from 473K to 1,73K. The Inconel 600 joints brazed with the 30Pd-50Ag-10Mn-10Co alloy had tensile strengths of 289MPa to 162MPa from 473K to 1,073K.

  1. [The Brazilian Unified Health System (SUS) is universal, but quotas are the norm].

    PubMed

    Viegas, Selma Maria da Fonseca; Penna, Cláudia Maria de Mattos

    2013-01-01

    In the context of the Unified Health System (SUS), health actions and services constitute a social right to be guaranteed by the State and managed under the responsibility of three autonomous spheres of government. This is a holistic multiple case study with a qualitative approach based on the assumptions of Comprehensive Everyday Sociology, which originated from a PhD thesis. It sought to understand the construction of comprehensive health practices in the daily work of family health teams and managers of the cities in Vale do Jequitinhonha - Minas Gerais, Brazil. The individuals studied were professionals from the Family Health Teams, support staff and managers with a total of 48 participants. In order to reveal the construction of the whole, the data show that "SUS is universal, but quotas are the norm." Bearing in mind its limitations, it is difficult to ensure that SUS is a right for all. Thus, regulation is essential to order, guide, define and optimize the use of resources available for comprehensive care and also guarantee public access to actions and services in a timely and equitable manner.

  2. [Whose is SUS? About the social representation of the users of the Family Health Program].

    PubMed

    Martins, Poliana Cardoso; Cotta, Rosângela Minardi Mitre; Mendes, Fábio Farias; Priore, Silvia Eloiza; Franceschinni, Sylvia do Carmo Castro; Cazal, Mariana de Melo; Batista, Rodrigo Siqueira

    2011-03-01

    The present study analyzes the representation of the users of SUS and PSF, presenting data obtained by semi-structured interviews, using the theoretical referential of the qualitative research. The results show a social representation marked by a focused vision and assistance, pointing to the concentration of public resources in poor segments of the society and centered in the biomedical model of attention. It stands out that PSF did not reach their objectives to provide changes in the praxis in health. In relation to the social control, it is observed that only 5.9% of the interviewees know the CMS. The presented data show a great ignorance by the studied population on the sanitary system and conquered social laws, and many people still see SUS as a "health plan for the poor". Due to the lived reality, the need of the implementation of strategies is emphasized for the reach of larger powerment/liberation of the population, seeking to build effective possibilities so that their actors will be active participant of the process of construction of a common project, actually based on the democratic ideals of SUS, being PSF strategically important in the accomplishment of these actions.

  3. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN*

    PubMed Central

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    Objective To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Materials and Methods Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. Results The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Conclusion Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS. PMID:25741070

  4. Changes to soil bacterial profiles as a result of Sus scrofa domesticus decomposition.

    PubMed

    Olakanye, Ayodeji O; Thompson, Tim; Komang Ralebitso-Senior, T

    2014-12-01

    The importance of cadaver decomposition knowledge for clandestine grave location cannot be over emphasised. Notwithstanding this, only a limited understanding is available on the resulting soil microbial community dynamics. To address this paucity, a pig leg (Sus scrofa domesticus; 5kg) was buried in freshly weighed (20kg) sandy loamy soil in a sealed microcosm (40cm height) in parallel with a soil only control. Both microcosms were perforated nine times at equal distances and maintained outside. Soil samples were collected through these perforations from the top (0-10cm), middle (10-20cm) and bottom (20-30cm) segments every three days for the first two weeks, and then weekly up to 14 weeks. PCR-DGGE gels quantified by 1D Phoretix showed increases in the cumulative soil community richness values of 43, 66 and 106 for the top, middle and bottom segments, respectively, in the presence of Sus scrofa domesticus. Shannon-Wiener's (H') and Simpon's (D) indices confirmed corresponding species diversity increases in the middle (H'=1.58-2.33; D=0.79-0.91) and bottom (H'=2.48-3.16; D=0.85-0.95) depths between days 10 and 71 compared with the control. In contrast, similar evenness was recorded for all segments in both the Sus scrofa domesticus and control soils.

  5. Torque teno sus virus (TTV) detection in aborted and slaughterhouse collected foetuses.

    PubMed

    Martínez-Guinó, L; Kekarainen, T; Maldonado, J; Aramouni, M; Llorens, A; Segalés, J

    2010-07-15

    The aim of this study was to estimate the presence of Torque teno sus virus (TTV) species in pig foetuses in order to assess the possible relationship between swine TTV infection and abortion in swine. A total of 98 abortion cases and foetuses collected from 55 pregnant sows at slaughterhouse were analysed by PCR for the presence of Torque teno sus virus 1 (TTV1) and Torque teno sus virus 2 (TTV2). All foetuses were necropsied and relevant tissues were collected, pooled, and submitted to DNA extraction. The overall prevalence of swine TTV1 and TTV2 in aborted foetuses (n = 98) was 17.0% and 29.6%, respectively. For slaughterhouse collected foetuses (n = 55), 10.9% were TTV1 PCR positive and 40.0% were positive for TTV2. There were no statistically significant differences when comparing prevalence of swine TTVs by type of sample (aborted versus slaughterhouse collected foetuses) or by gestation stage. The present work represents the first description of swine TTV infection in pig foetuses at different stages of gestation. Results obtained confirm that vertical transmission is an important route of TTVs dissemination. In addition, data obtained suggest that swine TTVs should not be considered as infectious agents responsible for abortion occurrence.

  6. Hispanos en la EPA: Rafael DeLeón

    EPA Pesticide Factsheets

    La diversidad de la fuerza laboral es importante para la Agencia de Protección Ambiental de EE.UU. (EPA, por sus siglas en inglés). Los empleados hispanos de la EPA contribuyen diariamente hacia la protección de la salud y el medio ambiente.

  7. Occurrence and first molecular characterization of Sarcocystis spp. in wild boars (Sus scrofa) and domestic pigs (Sus scrofa domesticus) in Romania: Public health significance of the isolates.

    PubMed

    Imre, Kálmán; Sala, Claudia; Morar, Adriana; Imre, Mirela; Ciontu, Cătălin; Chisăliță, Ion; Dudu, Andreea; Matei, Marius; Dărăbuș, Gheorghe

    2017-03-01

    Domestic and wild pigs, as intermediate hosts, can harbor tissue cysts of three Sarcocystis species namely S. miescheriana, S. suihominis and S. porcifelis. Out of them, S. suihominis is zoonotic. Romania is a country with high consumption of raw and/or undercooked traditional pork products. This fact may greatly favor the acquiring of the zoonotic Sarcocystis infections by humans, as definitive host. Based on this consideration and in order to investigate the occurrence and public health significance of Sarcocystis spp. in two western counties (Caraş-Severin and Timiş) of Romania, a total of 165 heart samples from hunted wild boars (Sus scrofa, n=101) and home slaughtered domestic pigs (Sus scrofa domesticus, n=64) were screened using microscopic fresh examination and molecular methods. Microscopic examination revealed the presence of sarcocysts in 60.4% of wild boars, and 23.4% of domestic pigs. Genetic characterization of isolates through the PCR-RFLP procedure, targeting the 18S rRNA gene, was successfully achieved for all microscopically positive samples, indicating the presence of a single species, S. miescheriana, in both hosts. The identity of 13 selected S. miescheriana isolates was also confirmed through sequencing. The tested hosts older than 27 months were found to be significantly higher infected (p<0.05) with Sarcocystis than the 6 to ≤27months age group. Although the human infective S. suihominis has not been registered, for a more reliable epidemiological picture, further molecular studies enrolling a larger number of animals and diagnosis on human intestinal Sarcocystis infections are still necessary.

  8. Drosophila Suppressor of Sable Protein [Su(s)] Promotes Degradation of Aberrant and Transposon-Derived RNAs▿

    PubMed Central

    Kuan, Yung-Shu; Brewer-Jensen, Paul; Bai, Wen-Li; Hunter, Cedric; Wilson, Carrie B.; Bass, Sarah; Abernethy, John; Wing, James S.; Searles, Lillie L.

    2009-01-01

    RNA-binding proteins act at various stages of gene expression to regulate and fine-tune patterns of mRNA accumulation. One protein in this class is Drosophila Su(s), a nuclear protein that has been previously shown to inhibit the accumulation of mutant transcripts by an unknown mechanism. Here, we have identified several additional RNAs that are downregulated by Su(s). These Su(s) targets include cryptic wild-type transcripts from the developmentally regulated Sgs4 and ng1 genes, noncoding RNAs derived from tandemly repeated αβ/αγ elements within an Hsp70 locus, and aberrant transcripts induced by Hsp70 promoter transgenes inserted at ectopic sites. We used the αβ RNAs to investigate the mechanism of Su(s) function and obtained evidence that these transcripts are degraded by the nuclear exosome and that Su(s) promotes this process. Furthermore, we showed that the RNA binding domains of Su(s) are important for this effect and mapped the sequences involved to a 267-nucleotide region of an αβ element. Taken together, these results suggest that Su(s) binds to certain nascent transcripts and stimulates their degradation by the nuclear exosome. PMID:19687295

  9. Decolonizing the Choctaws: Teaching LeAnne Howe's "Shell Shaker"

    ERIC Educational Resources Information Center

    Hollrah, Patrice

    2004-01-01

    "Shell Shaker" (2001) by LeAnne Howe (Choctaw) is a novel that gives students an opportunity to learn that the history and culture of the Choctaw Nation of Oklahoma are alive today. Winner of the Before Columbus Foundation American Book Award in 2002, the novel deals with two parallel stories that converge in the present, one about the eighteenth…

  10. Errol Le Cain: The Very Best Aspects of Book Illustration.

    ERIC Educational Resources Information Center

    Eve, Matthew

    1999-01-01

    Examines Errol Le Cain's eclectic illustration contributions to children's literature throughout his life. Relates life experiences and influences to his work as an illustrator. Suggests that he constantly changed and adapted his style according to the prose, its tone, and the setting, unlike most other contemporary British book artists. (SC)

  11. MoLeNET Mobile Learning Conference 2009: Research Papers

    ERIC Educational Resources Information Center

    Guy Parker, Ed.

    2010-01-01

    The Mobile Learning Network (MoLeNET) is a unique collaborative approach to encouraging, supporting, expanding and promoting mobile learning, primarily in English post-14 education and training, via supported shared cost mobile learning projects. Collaboration at national level involves participating institutions and the Learning and Skills…

  12. Some special features of the le chatelier-braun principle

    NASA Astrophysics Data System (ADS)

    Nesis, E. I.; Skibin, Yu. N.

    2000-07-01

    The relaxation reaction of a system that follows from the Le Chatelier-Braun principle and weakens the result of an external influence turns out to be more intense under a complex action. A method for quantitative determination of the weakening effect for simple and complex actions is suggested.

  13. Restorative Justice Scripts in Ursula K. Le Guin's "Voices"

    ERIC Educational Resources Information Center

    Oziewicz, Marek C.

    2011-01-01

    This essay examines restorative justice scripting in "Voices", the second volume of Ursula K. Le Guin's "Annals of the Western Shore." Narrated by a rape-child, "Voices" is the story of an occupied city-state and of how the conquered and the conquerors negotiate a formula for peaceful coexistence. They are able to do…

  14. Expectation of "Le Petit Prince"'s home

    NASA Astrophysics Data System (ADS)

    Abe, Masanao; Ohba, Yohei; Ishiguro, Masateru; Hasegawa, Sunao; Fuse, Tetsuharu

    2002-11-01

    We observed a few hundred meter-sized asteroid like "Le Petit Prince"'s home using Subaru telescope. The name of the asteroid is 1998 SF36, which is a target object of the Japanese asteroid sample return mission, MUSES-C. We report the results of the observations and expect the true picture of the tiny-sized asteroid.

  15. Le Chatelier's Principle and the Prediction Temperature on Solubilities.

    ERIC Educational Resources Information Center

    Fernandez-Prini, R.

    1982-01-01

    Discusses Le Chatelier's Principle from a thermodynamic perspective and applies it to the effect of temperature on the solubility of gases in liquids. Rationale of this discussion is to evaluate data in a previous article claimed to be contradictory to the Principle. (Author/JN)

  16. Le Chatelier's Principle Applied to the Temperature Dependence of Solubility.

    ERIC Educational Resources Information Center

    Treptow, Richard S.

    1984-01-01

    One effect of temperature is its influence on solubility, and that effect is used as a common example when teaching Le Chatelier's principle. Attempts to clarify the question of whether the principle holds in the case of the solubility of ionic compounds in water by investigating the literature data in detail. (JN)

  17. Le Dernier Cartoucherie: Refuge and the Performance of Care

    ERIC Educational Resources Information Center

    Fisek, Emine

    2008-01-01

    In 2003, the Paris-based theatre company Theatre du Soleil launched "Le Dernier Caravanserail: Odyssees", a collaborative creation based on stories that company members had collected from refugees at the Sangatte refugee camp outside Calais, among other locations. Scenes of moral reasoning dotted the six-hour spectacle, calling to mind…

  18. The Discourse Function of the Verbal Suffix -Le in Mandarin.

    ERIC Educational Resources Information Center

    Chu, Chauncey C.; Chang, W. Vincent

    It is proposed that the functions of the Mandarin verbal suffix "-le" are three: (1) for marking non-continual factual actions or events; (2) for indicating the "peak" in an event line; and (3) for explicitly marking anteriority of an action or event. Observations of written language drawn from newspaper articles and…

  19. Les enfants et le theatre (Children and the Theater).

    ERIC Educational Resources Information Center

    Ferrari, Josephine

    1980-01-01

    Describes a project involving the presentation of "Le petit prince" as an exercise in dramatics by children in a French-Italian bilingual education class. Two steps in the process are discussed: (1) the study of the text, and (2) the activities involved in getting the play ready for performance. (AMH)

  20. LHC, le Big Bang en éprouvette

    ScienceCinema

    None

    2016-07-12

    Notre compréhension de l’Univers est en train de changer… Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l’innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  1. LHC, le Big Bang en éprouvette

    SciTech Connect

    2010-04-07

    Notre compréhension de l’Univers est en train de changer… Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l’innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  2. LeRC in-house experimental research

    NASA Technical Reports Server (NTRS)

    Lyons, Valerie J.

    1992-01-01

    The topics covered include the following: LeRC in-house experimental research; combustion concepts; schedule for in-house experiments; lean premixed prevaporized combustion; comparisons of low NO(x) lean premixed/prevaporized data; rich burn/quick quench/lean burn (RQL); RQL combustion; fuel rich catalytic combustion; advanced diagnostics; and ceramic matrix liner test rig.

  3. Le syndrome d'embolie graisseuse post traumatique

    PubMed Central

    Berdai, Adnane Mohamed; Shimi, Abdelkarim; Khatouf, Mohammed

    2014-01-01

    Le syndrome d'embolie graisseuse est une complication grave des fractures des os longs, il est la conséquence de la dissémination des particules graisseuses dans la microcirculation. L'objectif de ce travail est de déterminer le profil épidémiologique, la présentation clinique et paraclinique de ce syndrome et sa prise en charge thérapeutique. Notre étude porte sur 11 cas de syndrome d'embolie graisseuse colligés au service de réanimation A1 au centre hospitalier universitaire Hassan II de Fès, de Janvier 2009 à Juin 2012. Le diagnostic positif est basé sur les critères de Gurd. Les cas collectés se caractérisent par la prédominance du sexe masculin, d'un âge inférieur à 40 ans, présentant une fracture fémorale. Ce syndrome survient souvent dans les 72 heures après le traumatisme. La présentation clinique est dominée par l'hypoxémie et les troubles de conscience. Sur le plan biologique: l'anémie et la thrombopénie sont les manifestations les plus fréquentes. La prise en charge est symptomatique, 63% des patients ont nécessité l'intubation et la ventilation. L’évolution n'est pas toujours bénigne. Nos résultats confirme le polymorphisme de la présentation clinique et paraclinique du syndrome d'embolie graisseuse. Le diagnostic de ce syndrome se base sur des critères cliniques, mais reste essentiellement un diagnostic d’élimination. La prise en charge est symptomatique. La prévention de ce syndrome est essentielle et se base sur une fixation précoce des fractures des os longs. PMID:25452829

  4. Simultaneous transgenic suppression of LePG and LeExp1 influences fruit texture and juice viscosity in a fresh market tomato variety.

    PubMed

    Powell, Ann L T; Kalamaki, Mary S; Kurien, Philip A; Gurrieri, Sergio; Bennett, Alan B

    2003-12-03

    Tomatoes are grown for fresh consumption or for processing of the fruit. Some ripening-associated processes of the fruit can either contribute to or degrade attributes associated with both fresh and processing quality. For example, cell wall disassembly is associated with loss of fresh fruit firmness as well as with loss of processed tomato product viscosity. Several enzymes contribute to cell wall polysaccharide disassembly. Polygalacturonase (PG, poly[1,4-alpha-d-galactouronide] glucanohydrolase, EC 3.2.1.15) is among the most abundant polysaccharide hydrolases in ripening tomato fruit and is the major contributor to pectin depolymerization. Expansin (LeExp1) is also abundant in ripening fruit and is proposed to contribute to cell wall disassembly by nonhydrolytic activity, possibly by increasing substrate accessibility to other enzymes. Suppression of either LePG or LeExp1 expression alone results in altered softening and/or shelf life characteristics. To test whether simultaneous suppression of both LePG and LeExp1 expression influences fruit texture in additive or synergistic ways, transgenic Lycopersicon esculentum var. Ailsa Craig lines with reduced expression of either LePG or LeExp1 were crossed. Fruits from the third generation of progeny, homozygous for both transgenic constructs, were analyzed for firmness and other quality traits during ripening on or off the vine. In field-grown transgenic tomato fruit, suppression of LeExp1 or LePG alone did not significantly increase fruit firmness. However, fruits suppressed for both LePG and LeExp1 expression were significantly firmer throughout ripening and were less susceptible to deterioration during long-term storage. Juice prepared from the transgenic tomato fruit with reduced LePG and LeExp1 expression was more viscous than juice prepared from control fruit.

  5. Le traitement familial des enfants et des adolescents anorexiques : Des lignes directrices pour le médecin communautaire

    PubMed Central

    Findlay, S; Pinzon, J; Taddeo, D; Katzman, DK

    2010-01-01

    L’anorexie mentale (AM) est une maladie grave qui met la vie en danger et qui fait généralement son apparition pendant l’adolescence. Les données probantes au sujet du traitement optimal de l’AM chez les enfants et les adolescents sont en croissance, mais il reste beaucoup à apprendre. Même si les démarches thérapeutiques actuelles varient au Canada et ailleurs, les données jusqu’à présent indiquent que le traitement familial (TF) est le plus efficace pour les enfants et les adolescents anorexiques. Un élément essentiel du modèle de TF, c’est que les parents sont investis de la responsabilité de rétablir la santé physique de leur enfant et de s’assurer de la reprise complète de son poids. Le médecin qui comprend les principes fondamentaux et la philosophie du TF peut mettre en place les éléments de cette intervention fondée sur des faits probants auprès des jeunes patients anorexiques et de leur famille.

  6. Connecting Instructional and Cognitive Aspects of an LE: A Study of the Global Seminar Project

    ERIC Educational Resources Information Center

    Savelyeva, Tamara

    2012-01-01

    My research problem is based on the lack of unifying conceptual cohesion between the discourses concerning cognitive and instructional aspects of learning environments (LE). I contrast that lack with practical developments of LE studies connected at the level of practical implementation and evaluation. Next, I briefly review the LE boundaries,…

  7. Differentiation of European wild boar (Sus scrofa scrofa) and domestic swine (Sus scrofa domestica) meats by PCR analysis targeting the mitochondrial D-loop and the nuclear melanocortin receptor 1 (MC1R) genes.

    PubMed

    Fajardo, Violeta; González, Isabel; Martín, Irene; Rojas, Marı A; Hernández, Pablo E; Garcı A, Teresa; Martín, Rosario

    2008-03-01

    This work describes the differentiation of European wild boar (Sus scrofa scrofa) and domestic swine (Sus scrofa domestica) meats by PCR targeting sequences from two molecular markers: the mitochondrial displacement loop (D-loop) region and the nuclear melanocortin receptor 1 (MC1R) gene. A polymorphic D-loop fragment (∼270bp) was amplified and sequenced in a number of wild and domestic Sus scrofa meat samples, to find a nucleotide region suitable for PCR-RFLP analysis. Sequence data showed the presence of only a few point mutations across Sus scrofa D-loop sequences, not allowing direct discrimination between wild boar and domestic swine meats. Later, the MC1R gene was targeted and Sus scrofa-specific primers designed to amplify a 795bp MC1R fragment. Subsequent RFLP analysis of the MC1R swine-specific amplicons allowed selection of BspHI and BstUI endonucleases to carry out intraspecific Sus scrofa differentiation. Digestion of MC1R amplicons with the chosen enzymes generated characteristic PCR-RFLP profiles that allowed discrimination among meats from wild and domestic swine specimens. The technique also enabled the detection of samples that yielded heterozygous profiles, suggesting hybrids resulting from wild boar and domestic pig breeding. The PCR-RFLP reported here, targeting the MC1R gene may be routinely applied to verify the correct labelling of game products.

  8. Pierre Curie et lele de la symétrie dans les lois physiques

    NASA Astrophysics Data System (ADS)

    de Gennes, P. G.

    Pierre et Jacques Curie découvraient il y a cent ans le phénomène de piézoélectricité : comment un cristal, de suffisamment basse symétrie, développe une polarization lorsqu'il est soumis à une contrainte mécanique. Pierre Curie n'a alors que 21 ans ! Et pourtant ses notes lapidaires aux Comptes Rendus datées de 1880 et 1881 [1] portent en elles tout l'essentiel du phénomène : charges superficielles proportionnelles à la pression, indépendantes de l'épaisseur du cristal, etc. Lorsque quelques mois plus tard, Lippmann prédit l'effet inverse (déformation du crystal sous champ électrique), les frères Curie imaginent tout de suite un dispositif admirablement simple pour détecter ces très faibles déformations. Ils couplent mécaniquement le cristal étudié avec un deuxième cristal piézoélectrique qui joue lele d'un détecteur; ce dernier transforme le signal mécanique du premier cristal en un signal électrique mesuré a l'électromètre ! Les résultats confirment brillamment la prédiction de Lippmann. Et pourtant, les moyens engagés sont très modestes — les champs électriques, par exemple, sont calibrés par la longueur d'une décharge dans l'air…

  9. [Methodology for construction of a panel of indicators for monitoring and evaluation of unified health system (SUS) management].

    PubMed

    Tamaki, Edson Mamoru; Tanaka, Oswaldo Yoshimi; Felisberto, Eronildo; Alves, Cinthia Kalyne de Almeida; Drumond Junior, Marcos; Bezerra, Luciana Caroline de Albuquerque; Calvo, Maria Cristina Marino; Miranda, Alcides Silva de

    2012-04-01

    This study sought to develop methodology for the construction of a Panel for the Monitoring and Evaluation of Management of the Unified Health System (SUS). The participative process used in addition to the systematization conducted made it possible to identify an effective strategy for building management tools in partnership with researchers, academic institutions and managers of the SUS. The final systematization of the Panel selected indicators for the management of the SUS in terms of Demand, Inputs, Processes, Outputs and Outcomes in order to provide a simple, versatile and useful tool for evaluation at any level of management and more transparent and easier communication with all stakeholders in decision-making. Taking the management of the SUS as the scope of these processes and practices in all normative aspects enabled dialog between systemic theories and those which consider the centrality of the social actor in the decision-making process.

  10. Detection of Echinococcus granulosus G3 in a Wild Boar ( Sus scrofa ) in Central Italy Using PCR and Sequencing.

    PubMed

    Di Paolo, Antonella; Piseddu, Toni; Sebastianelli, Martina; Manuali, Elisabetta; Corneli, Sara; Paniccià, Marta; Papa, Paola; Viali, Selina; Mazzone, Piera

    2017-01-24

    We report cystic echinococcosis in a free-living wild boar ( Sus scrofa ) in Europe. Parasites were identified by histopathology and molecular techniques, revealing Echinococcus granulosus of the G3 genotype.

  11. Multivariate analysis of mandible in the Ryukyu wild pig (Sus scrofa riukiuanus).

    PubMed

    Endo, H; Kurohmaru, M; Hayashi, Y; Ohsako, S; Matsumoto, M; Nishinakagawa, H; Yamamoto, H; Kurosawa, Y; Tanaka, K

    1998-06-01

    We measured adult mandibles of Ryukyu wild pig (Sus scrofa riukiuanus) from Tokunoshima Island and compared the osteometrical data with those from six Nansei Islands. The mandibles in Tokunoshima Island were larger than those from Amami-Oshima and Okinawa Islands in some measurements. We concluded that the size cline was not statistically recognized among populations. In the principal component analysis, the size cline was also denied, and the separation could be made among island populations in female. It is suggested that the populations in Tokunoshima and Okinawa Islands may be different from those in Amami-Oshima, Kakeroma, Ishigaki and Iriomote Islands in skull proportion.

  12. Epidemiologic study of lung parasites (Metastrongylus spp.) in wild boar (Sus scrofa) in southwestern Spain.

    PubMed

    García-González, Ángela María; Pérez-Martín, Juan Enrique; Gamito-Santos, José Antonio; Calero-Bernal, Rafael; Alcaide Alonso, María; Frontera Carrión, Eva María

    2013-01-01

    We analyzed 927 wild boars (Sus scrofa) in southwestern Spain during the hunting seasons of 2004/2005 to 2008/2009. Respiratory tracts were examined for lung nematodes (Metastrongylus spp.). The prevalence of Metastrongylus spp. was 41.1%. The most frequently isolated species were Metastrongylus apri (71.4%), Metastrongylus pudendotectus (28.0%), and Metastrongylus salmi (0.6%). Prevalence and infection intensity were greater in young animals (<1 yr old) than in older animals. There were no significant differences in prevalence between sexes. Prevalence and intensity of infection were higher in areas of high altitude and high rainfall.

  13. First molecular identification of Sarcocystis miescheriana (Protozoa, Apicomplexa) from wild boar (Sus scrofa) in Iran.

    PubMed

    Kia, Eshrat Beigom; Mirhendi, Hossein; Rezaeian, Mostafa; Zahabiun, Farzaneh; Sharbatkhori, Mitra

    2011-03-01

    Sarcocystis isolate obtained from the thigh muscle of a wild boar (Sus scrofa), captured from Gilan Province, northern Iran, was subjected to molecular analysis. Genomic DNA was obtained using a DNA extraction tissue kit and Polymerase chain reaction (PCR) for amplification of the 18S ribosomal DNA region yielded an 842 bp DNA band on agarose gel. Analysis of DNA sequencing by BLAST confirmed the isolate as Sarcocystis miescheriana and the sequence was deposited in GenBank by Accession No. GU395554. This is the first molecular identification of an isolate of S. miescheriana in Iran.

  14. Necropsy and coprology in wild boar (Sus scrofa) in Livorno Mountain Park (Tuscany, Central Italy).

    PubMed

    Magi, M; Bertani, M; Dell'Omodarme, M; Prati, M C

    2004-09-01

    The present research analyses the reliability of coprological tests, both quantitative and qualitative, as indicators of the parasite burden of hosts, using data from wild boars (Sus scrofa) living in Livorno Mountain Park (Tuscany, Central Italy). In the case of intestinal strongyles, which turned out to be the dominant helminths of wild boars, the qualitative coprological test appears as a bad predictor of the real parasite situation of the herds, due to the high number of false negative results (34 animals out of 68). On the other hand, the positive predictive value of the test is high (90%). The quantitative test is significantly correlated with the individual parasite burden of wild boars.

  15. A Serosurvey for Brucellosis in Wild Boar (Sus scrofa) in Sardinia, Italy.

    PubMed

    Pilo, Cristian; Addis, Giuseppe; Deidda, Manuela; Tedde, Maria Tania; Liciardi, Manuele

    2015-10-01

    Porcine brucellosis is a zoonotic disease caused by Brucella suis and hosted by pigs (Sus scrofa). Both domestic pigs and wild boars are affected. We measured the prevalence of antibody to Brucella spp. in wild boars in Sardinia, Italy. During 1 November 2009 to 31 January 2010, we collected 570 serum samples from legally hunted wild boars and tested them using a commercial competitive enzyme-linked immunosorbent assay. Sex and age class of the sampled wild boars were also recorded. Thirty-five samples were positive for an apparent antibody prevalence of 6.1%. Antibody prevalences did not differ between sexes or among age classes.

  16. Prevalence of antibodies to Toxoplasma gondii in South Korean wild boar (Sus scrofa coreanus).

    PubMed

    Jeong, Wooseog; Yoon, Hachung; Kim, Yong Kwan; Moon, Oun-Kyong; Kim, Do-Soon; An, Dong-Jun

    2014-10-01

    Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite and a commonly encountered pathogen in humans and animals. The wild boar (Sus scrofa coreanus) is considered a good indicator when monitoring environmental contamination by T. gondii. We surveyed the prevalence of antibodies against T. gondii in wild boars from South Korea. Blood samples were collected from 426 wild boars captured in eight provinces of South Korea during the hunting seasons in 2008-12. Antibodies against T. gondii were detected using an indirect enzyme-linked immunosorbent assay in samples from 152 of boars, indicating an overall antibody prevalence of 36% (95% confidence interval=31-40%).

  17. Cytochrome b based genetic differentiation of Indian wild pig (Sus scrofa cristatus) and domestic pig (Sus scrofa domestica) and its use in wildlife forensics.

    PubMed

    Gupta, Sandeep Kumar; Kumar, Ajit; Hussain, Syed Ainul; Vipin; Singh, Lalji

    2013-06-01

    The Indian wild pig (Sus scrofa cristatus) is a protected species and listed in the Indian Wildlife (Protection) Act, 1972. The wild pig is often hunted illegally and sold in market as meat warranting punishment under law. To avoid confusion in identification of these two subspecies during wildlife forensic examinations, we describe genetic differentiation of Indian wild and domestic pigs using a molecular technique. Analysis of sequence generated from the partial fragment (421bp) of mitochondrial DNA (mtDNA) cytochrome b (Cyt b) gene exhibited unambiguous (>3%) genetic variation between Indian wild and domestic pigs. We observed nine forensically informative nucleotide sequence (FINS) variations between Indian wild and domestic pigs. The overall genetic variation described in this study is helpful in forensic identification of the biological samples of wild and domestic pigs. It also helped in differentiating the Indian wild pig from other wild pig races. This study indicates that domestic pigs in India are not descendent of the Indian wild pig, however; they are closer to the other wild pig races found in Asia and Europe.

  18. Ultrafast intramolecular charge transfer with N-(4-cyanophenyl)carbazole. Evidence for a LE precursor and dual LE + ICT fluorescence.

    PubMed

    Galievsky, Victor A; Druzhinin, Sergey I; Demeter, Attila; Mayer, Peter; Kovalenko, Sergey A; Senyushkina, Tamara A; Zachariasse, Klaas A

    2010-12-09

    The photophysics of N-(4-cyanophenyl)carbazole (NP4CN) was investigated by using absorption and fluorescence spectra, picosecond fluorescence decays, and femtosecond transient absorption. In the nonpolar n-hexane as well as in the polar solvent acetonitrile (MeCN), a locally excited (LE) state is detected, as a precursor for the intramolecular charge transfer (ICT) state. A LE → ICT reaction time τ(2) at 22 °C of 0.95 ps in ethyl cyanide (EtCN) and 0.32 ps in MeCN is determined from the decay of the LE excited state absorption (ESA) maximum around 620 nm. In the ESA spectrum of NP4CN in n-hexane at a pump-probe delay time of 100 ps, an important contribution of the LE band remains alongside the ICT band, in contrast to what is observed in EtCN and MeCN. This shows that a LE ⇄ ICT equilibrium is established in this solvent and the ICT reaction time of 0.5 ps is equal to the reciprocal of the sum of the forward and backward ICT rate constants 1/(k(a) + k(d)). In the photostationary S(0) → S(n) absorption spectrum of NP4CN in n-hexane and MeCN, an additional CT absorption band appears, absent in the sum of the spectra of its electron donor (D) and acceptor (A) subgroups carbazole and benzonitrile. This CT band is located at an energy of ∼4000 cm(-1) lower than for N-phenylcarbazole (NPC), due to the larger electron affinity of the benzonitrile moiety of NP4CN than the phenyl subunit of NPC. The fluorescence spectrum of NP4CN in n-hexane at 25 °C mainly consists of a structured LE emission, with a small ICT admixture, indicating that a LE → ICT reaction just starts to occur under these conditions. In di-n-pentyl ether (DPeE) and di-n-butyl ether (DBE), a LE emission is found upon cooling at the high-energy edge of the ICT fluorescence band, caused by the onset of dielectric solvent relaxation. This is not the case in more polar solvents, such as diethyl ether (DEE) and MeCN, in which a structureless ICT emission band fully overlaps the strongly quenched LE

  19. Sur le chaos Lagrangien dans une cuve elliptique

    NASA Astrophysics Data System (ADS)

    Saatdjian, E.; Chassaing, M. I.; Midoux, N.; André, J. C.

    1995-02-01

    A viscous fluid is introduced into the annular space between two concentric, confocal ellipses. The inner and outer walls can be displaced along their circumference. A small quantity of fluorescent dye is introduced into the fluid and deformation and mixing are studied for the case of periodic boundary movement. An analytical solution in elliptical coordinates has been previously derived for creeping flow conditions. Poincaré sections for a given set of parameters indicate that counter-rotation leads to a more chaotic behaviour than co-rotation, this result is confirmed experimentally. This geometry can also be used as a heat exchanger. By a suitable choice of the parameters, the heat transfer for steady boundary motion can be increased by more than 50% with respect to the concentric cylinder system. If the inner and outer walls are displaced time-periodically, the heat transfer rate obtained can be more than double the rate obtained between concentric cylinders. Un fluide visqueux est introduit dans une cuve de géométrie elliptique, les parois interne et externe de cette cuve tournent suivant le périmètre de l'ellipse. Une petite quantité de traceur fluorescent est introduite dans le fluide et la déformation de l'élément marqué, lorsque le mouvement des deux parois est périodique, est étudiée. Pour cet écoulement où le nombre de Reynolds est très inférieur à 1 (régime de Stokes) et à partir d'une solution analytique récemmnent obtenue pour le cas stationnaire, des sections de Poincaré ont été tracées pour le cas d'une contra-rotation et d'une co-rotation. Les résultats expérimentaux montrent que, pour un protocole de mélange discontinu approprié, cette géométrie mène vers un mélange chaotique après un petit nombre de périodes. Par ailleurs, il est préférable de faire tourner les ellipses en contra-rotation. Ce résultat, en contradiction avec ceux déjà obtenus dans l'espace annulaire entre cylindres excentrés tournants, est

  20. The Use of Genomics in Conservation Management of the Endangered Visayan Warty Pig (Sus cebifrons)

    PubMed Central

    Bosse, Mirte; Crooijmans, Richard P. M. A.; Madsen, Ole; Schaftenaar, Willem; Ryder, Oliver A.; Megens, Hendrik-Jan

    2016-01-01

    The list of threatened and endangered species is growing rapidly, due to various anthropogenic causes. Many endangered species are present in captivity and actively managed in breeding programs in which often little is known about the founder individuals. Recent developments in genetic research techniques have made it possible to sequence and study whole genomes. In this study we used the critically endangered Visayan warty pig (Sus cebifrons) as a case study to test the use of genomic information as a tool in conservation management. Two captive populations of S. cebifrons exist, which originated from two different Philippine islands. We found some evidence for a recent split between the two island populations; however all individuals that were sequenced show a similar demographic history. Evidence for both past and recent inbreeding indicated that the founders were at least to some extent related. Together with this, the low level of nucleotide diversity compared to other Sus species potentially poses a threat to the viability of the captive populations. In conclusion, genomic techniques answered some important questions about this critically endangered mammal and can be a valuable toolset to inform future conservation management in other species as well. PMID:27069913

  1. [SUS management and monitoring and evaluation practices: possibilities and challenges for building a strategic agenda].

    PubMed

    Carvalho, André Luis Bonifácio de; Souza, Maria de Fátima; Shimizu, Helena Eri; Senra, Isabel Maria Vilas Boas; Oliveira, Kátia Cristina de

    2012-04-01

    This paper deals with the challenges involved in institutionalizing Monitoring and Evaluation practices within the scope of management of the Brazilian Unified Health System (SUS), based on the creation of a strategic agenda. This is structured around actions by the Federal Administration, from the perspective of defining the scope of the federative relationship. A summarized literature review is thus presented, placing into context the current SUS management process, which is based on the Pact for Health as well as theoretical and operational aspects inherent to monitoring and evaluation practices. The approach related to the strategic agenda highlights the creation of mechanisms that underpin the political and institutional decision, namely the creation of financial incentives and the development of technical mechanisms. These include organizational strategies for qualifying management teams and conducting studies and research and the dissemination of strategic information. These processes are based on the concept of providing for the management specificities in the different spheres of management based on a broad cooperation process involving teaching and research institutions and international organizations as well as the managers themselves.

  2. Pig-mentation: postmortem iris color change in the eyes of Sus scrofa.

    PubMed

    Abraham, Elizabeth; Cox, Margaret; Quincey, David

    2008-05-01

    Experienced forensic pathologists and examiners may be familiar with the phenomenon of postmortem iris color change; however, only Knight, Simpson's forensic medicine, Arnold, London, 1997; Ref. 1 and Saukko and Knight, Knight's forensic pathology, 3rd ed., Arnold, London, 2004; Ref. 2 have referred to it in the literature, and to date, there have been no published scientific research studies on this taphonomic artifact. A controlled experiment was conducted of postmortem changes to isolated Sus scrofa eyes. The eyes (n = 137) were separated into three groups and each sample was observed for 3-day postmortem at a different temperature. In addition, a Sus scrofa head was obtained to observe postmortem changes of eyes in situ. All isolated blue eyes in the experiment, at room temperature and higher, changed to brown/black within 48 h. The in situ blue eye, at room temperature, turned brown/black within 72 h. If iris color consistently changes postmortem in humans, then this taphonomic artifact must be incorporated into victim identification protocol, including disaster victim identification software, and autopsy reports to prevent inaccurate victim identification and inappropriate exclusion from the identification process.

  3. Comparison of two codon optimization strategies enhancing recombinant Sus scrofa lysozyme production in Pichia pastoris.

    PubMed

    Zhu, D; Cai, G; Wu, D; Lu, J

    2015-05-16

    Lysozyme has played an important role in animal feed additive industry, food additive industry and biological engineering. For improving expression efficiency of recombinant lysozyme from Sus scrofa, two genes respectively designed by the most used codon optimization strategies, "one amino acid one codon" and "codon randomization", were synthesized and expressed in Pichia pastoris X—33. At shaking flask level, Sus scrofa lysozyme (SSL) under two conditions had a highest activity of 153.33±10.41 and 538.33±15.18 U/mL after a 5 days induction of 1% methanol, with secreted protein concentration 80.03±1.94 and 239.60±4.16 mg/L, respectively. Compared with the original SSL gene, the expression of optimized SSL gene by the second strategy showed a 2.6 fold higher level, while the first method had no obvious improvement in production. In total secreted protein, the proportions of recombinant SSL encoded by the original gene, first method optimized gene and the second—strategy optimized one were 75.06±0.25%, 74.56±0.14% and 79.00±0.14%, respectively, with the same molecular weight about 18 kDa, optimum acidity pH 6.0 and optimum temperature 35degC.

  4. Cryptosporidium suis and Cryptosporidium scrofarum in Eurasian wild boars (Sus scrofa) in Central Europe.

    PubMed

    Němejc, Karel; Sak, Bohumil; Květoňová, Dana; Hanzal, Vladimír; Janiszewski, Paweł; Forejtek, Pavel; Rajský, Dušan; Ravaszová, Petra; McEvoy, John; Kváč, Martin

    2013-11-08

    From 2011 to 2012, to identify Cryptosporidium spp. occurrence in Eurasian wild boars (Sus scrofa) 29 randomly selected localities (both forest areas and enclosures) across the Central European countries of Austria, the Czech Republic, Poland, and the Slovak Republic were investigated. Cryptosporidium oocysts were microscopicaly detected in 11 out of 460 faecal samples examined using aniline-carbol-methyl violet staining. Sixty-one Cryptosporidium infections, including the 11 infections that were detected by microscopy, were detected using genus- or species-specific nested PCR amplification of SSU rDNA. This represents a 5.5 fold greater sensitivity for PCR relative to microscopy. Combining genus- and species-specific PCR tools significantly changes the perspective on the occurrence of Cryptosporidium spp. in wild boars. While RFLP and direct sequencing of genus specific PCR-amplified products revealed 56 C. suis (20) and C. scrofarum (36) monoinfections and only 5 mixed infections of these species, species-specific molecular tools showed 44 monoinfections and 17 mixed infections with these species. PCR analysis of the gp60 gene did not reveal any other Cryptosporidium infections. Similar to domestic pigs, C. scrofarum was detected as a dominant species infecting adult Eurasian wild boars (Sus scrofa). Cryptosporidium infected wild boars did not show signs of clinical disease. This report is perhaps the most comprehensive survey of cryptosporidial infection in wild boars.

  5. Le facteur XII de la coagulation: bien plus qu’un stabilisant de la fibrine

    PubMed Central

    Messaoudi, N.; Lamaalmi, F.; Chakour, M.; Belmekki, A.; Naji, M.

    2011-01-01

    Summary Les Auteurs considèrent lele du facteur XIII de la coagulation dans la cicatrisation. Identifié depuis 1923, lele du facteur XIII ou le facteur stabilisant de la fibrine dans la coagulation a été bien élucidé. Son rôle dans la cicatrisation suggéré dès 1960 est méconnu par les hématologistes et les médecins prenant en charge les brûlés. Les Auteurs se proposent de mettre la lumière sur ce rôle, qui reste encore mystérieux et mérite d’être élucidé. PMID:21991236

  6. [Complications in Le Fort facial fractures combined with craniocerebral trauma].

    PubMed

    Dimov, Zh; Abramov, G; Dimov, K; Kr'stev, N; Kr'stev, D

    1999-01-01

    The present research is based on the most frequent traumas and fractures in the middle zone of the face (second and third type by Rene le Fort) and the proceeded from them complications for a period of four years in the clinic of Neurosurgery in NIUMN "Pirogov". From the 280 patients that were studied the complications were observed in 54 of them. We worked up the received results statistically and presented them in drawing.

  7. Le sumatriptan intranasal pour la migraine chez les enfants

    PubMed Central

    Goldman, Ran D.; Meckler, Garth D.

    2015-01-01

    Résumé Question Je vois de plus en plus d’enfants et d’adolescents qui souffrent de céphalées pouvant se classer dans la catégorie des migraines. J’ai fait des lectures sur le sumatriptan par voie intranasale comme thérapie abortive. Est-ce un traitement efficace? Réponse La migraine aiguë chez les enfants et les adolescents est fréquente et difficile à traiter. Le sumatriptan intranasal est une option sûre et généralement efficace pour les enfants et les adolescents. La dose actuellement recommandée est de 20 mg pour les enfants qui pèsent plus de 40 kg et de 10 mg pour ceux dont le poids se situe entre 20 et 39 kg. Il faudrait faire des études de plus grande envergure pour contrecarrer les limitations des échantillons de petite taille et mieux comprendre la faible concentration plasmique et les effets placebo observés dans les études jusqu’à présent.

  8. Airborne pollen and spores of León (Spain)

    NASA Astrophysics Data System (ADS)

    Fernández-González, Delia; Suarez-Cervera, María; Díaz-González, Tomás; Valencia-Barrera, Rosa María

    1993-06-01

    A qualitative and quantitative analysis of airborne pollen and spores was carried out over 2 years (from September 1987 to August 1989) in the city of León. Slides were prepared daily using a volumetric pollen trap, which was placed on the Faculty of Veterinary Science building (University of León) 12m above ground-level. Fifty-one pollen types were observed; the most important of these were: Cupressaceae during the winter, Pinus and Quercus in spring, and Poaceae, Leguminosae and Chenopodiaceae in the summer. The results also showed the existence of a rich mould spore assemblage in the atmosphere. The group of Amerospores ( Penicillium, Aspergillus and Cladosporium) as well as Dictyospores ( Alternaria) were the most abundant; Puccinia was common in the air in August. Fluctuations in the total pollen and spores m3 of air were compared with meteorological parameters (temperature, relative humidity and rainfall). From the daily sampling of the atmosphere of León, considering the maximum and minimum temperature and duration of rainfall, the start of the pollen grain season was observed generally to coincide with a rise in temperature in the absence of rain.

  9. Accuracy of a LeFort I maxillary osteotomy.

    PubMed

    Semaan, Steven; Goonewardene, Mithran S

    2005-11-01

    An optimal outcome of combined surgery and orthodontics involving the maxilla is dependent on many factors. Accurate placement of the maxilla by the surgical team is ultimately of paramount importance. The aim of this retrospective study was to evaluate the accuracy of LeFort I maxillary osteotomy with respect to the presurgical prediction. The sample comprised 42 patients (33 females, nine males) who had undergone LeFort I osteotomy procedure alone or in combination with a mandibular osteotomy with or without genioplasty. Tracings of presurgical and immediate postsurgical lateral cephalograms and surgical predictions were digitized and compared using Quick Ceph software analysis. Vertical and horizontal measurements to various skeletal landmarks were used to assess the discrepancy between the predicted maxillary position and the actual postsurgical result. Statistically significant differences were found between the predicted and actual postsurgical maxillary molar vertical position, and significant differences were also found for the palatal plane angular measurements. Two surgical teams were compared, and surgical team 1 had significantly less variation in the surgical outcomes than did surgical team 2. When single-jaw and bimaxillary surgery were compared, no significant differences were found. Similarly, there were no statistically significant differences found when assessing the primary direction of movement (impaction vs downgraft vs advancement). Overall, 66% of the results were within two mm of prediction and 26% of the results were within one mm of prediction. A LeFort I maxillary osteotomy can be an accurate procedure with a wide range of discrepancy.

  10. Sequence diversity and enzyme activity of ferric-chelate reductase LeFRO1 in tomato.

    PubMed

    Kong, Danyu; Chen, Chunlin; Wu, Huilan; Li, Ye; Li, Junming; Ling, Hong-Qing

    2013-11-20

    Ferric-chelate reductase which functions in the reduction of ferric to ferrous iron on root surface is a critical protein for iron homeostasis in strategy I plants. LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato. To identify the natural variations of LeFRO1 and to assess their effect on the ferric-chelate reductase activity, we cloned the coding sequences of LeFRO1 from 16 tomato varieties collected from different regions, and detected three types of LeFRO1 (LeFRO1(MM), LeFRO1(Ailsa) and LeFRO1(Monita)) with five amino acid variations at the positions 21, 24, 112, 195 and 582. Enzyme activity assay revealed that the three types of LeFRO1 possessed different ferric-chelate reductase activity (LeFRO1(Ailsa) > LeFRO1(MM) > LeFRO1(Monita)). The 112th amino acid residue Ala of LeFRO1 is critical for maintaining the high activity of ferric-chelate reductase, because modification of this amino acid resulted in a significant reduction of enzyme activity. Further, we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1. In conclusion, the findings are helpful to understand the natural adaptation mechanisms of plants to iron-limiting stress, and may provide new knowledge to select and manipulate LeFRO1 for improving the iron deficiency tolerance in tomato.

  11. Overexpression of GhSusA1 increases plant biomass and improves cotton fiber yield and quality.

    PubMed

    Jiang, Yanjie; Guo, Wangzhen; Zhu, Huayu; Ruan, Yong-Ling; Zhang, Tianzhen

    2012-04-01

    Cotton (Gossypium spp.) is an important economic crop and the largest source of textile fiber in the world. However, to date, only a few genes have been identified that exhibit critical roles in fiber development, and few has shown positive effects on fiber yield and quality in transgenic cotton. Here, we report the characterization of a novel sucrose synthase (SusA1) gene from a superior quality fiber germplasm line 7235 in Gossypium hirsutum. By association analysis, GhSusA1 was highly correlated with fiber qualities in (7235× TM-1) recombinant inbred lines based on polymorphism of GhSusA1 between 7235 and TM-1. Subsequently, based on an interspecific population of 141 BC₁ individuals generated from the cross between TM-1 and Gossypium barbadense line, Hai7124, we further mapped GhSusA1 genes on homeologous chromosomes A8 (chro.8) and D8 (chro.24). Suppression of GhSusA1 in transgenic cotton reduced fiber quality and decreased the boll size and seed weight. Importantly, overexpression of this gene increased fiber length and strength, with the latter indicated by the enhanced thickening of cell wall during secondary wall formation stage. Moreover, increasing GhSusA1 transcript abundance in vegetative tissues led to elevated seedling biomass. Together, these findings identified GhSusA1 as a key regulator of sink strength in cotton, which is tightly associated with productivity, and hence a promising candidate gene that can be developed to increase cotton fiber yield and quality.

  12. Nutrition chez le brûlé

    PubMed Central

    Perro, G.

    2016-01-01

    Summary La nutrition est un challenge chez le brûlé, paradigme de l’agressé. Les points importants sont les apports entéraux précoces par sonde gastrique voire post pyloriques, la position proclive > 30°, la surveillance du transit et sa régulation par gastro ou entéro-kinétiques, la surveillance du poids, la quantification des apports avec supplémentation parentérale en cas de retard protéino énergétique. Chez l’enfant, l’adhésion à l’alimentation est difficile, de même que chez le senior, où une évaluation nutritionnelle initiale dépiste souvent une dénutrition préexistante. Les compléments alimentaires seront largement prescrits chez les patients de gravité intermédiaire. Les obèses bénéficieront d’un régime hypocalorique et hyperprotidique. Chez l’insuffisant rénal non dialysé il convient de limiter les apports en potassium. En cas brûlure périnéale, on peut proposer soit une constipation de courte durée, soit la mise en place d’un entéro-collecteur, les indications de colostomie étant devenues rares. Les apports entéraux sont difficiles à gérer en cas de décubitus ventral pour SDRA. Chez le brûlé grave de réanimation, l’accent doit plus être mis sur la qualité des nutriments que sur leur quantité. Les anciennes formules d’estimation calorique conduisaient à une surnutrition difficile à administrer et en général mal tolérée; la quantification mesurée par calorimétrie indirecte ou estimée par la formule de Toronto est bien plus adaptée. Plus récemment, l’instauration d’une immunonutrition (supplémentation en vitamines et oligo-éléments, glutamine, arginine, acide Ω 3 et contrôle raisonné de la glycémie) a été proposée pour réduire le stress oxydatif et l’inflammation provoqués par l’accident. PMID:27857647

  13. Le tetanos chez le grand enfant dans un hôpital pédiatrique à Yaoundé, Cameroun

    PubMed Central

    Ntoto Njiki Kinkela, Mina; Nguefack, Félicitée; Mbassi Awa, Hubert; Chelo, David; Enyama, Dominique; Mbollo Kobela, Marie; Koki Ndombo, Paul Olivier

    2012-01-01

    Le tétanos est évitable par la vaccination, mais peut survenir en cas d'une immunisation incomplète. Nous avons mené une étude sur les dossiers médicaux des enfants admis pour tétanos entre 2008-2009 au Centre Mère et Enfant de la Fondation Chantal BIYA à Yaoundé. Le but était d'analyser les circonstances de survenue et les manifestations cliniques du tétanos chez le grand enfant, afin de proposer des stratégies de prévention adaptées au contexte camerounais. Le statut vaccinal était inconnu chez un patient, les autres (80%) n'avaient pas reçu de rappel vaccinal. Les portes d'entrée étaient les plaies aux membres, l'une était secondaire à une injection médicamenteuse. Tous ont présenté le tétanos généralisé. Le décès était survenu chez un patient. Le tétanos n'est pas rare chez le grand enfant au Cameroun. Il se dégage ainsi la problématique des rappels vaccinaux. PMID:22514771

  14. High prevalence of hepatitis E virus in wild boar (Sus scrofa) in Yamaguchi Prefecture, Japan.

    PubMed

    Hara, Yuka; Terada, Yutaka; Yonemitsu, Kenzo; Shimoda, Hiroshi; Noguchi, Keita; Suzuki, Kazuo; Maeda, Ken

    2014-04-01

    Hepatitis E virus (HEV) causes a food- and water-borne disease in humans, and Japanese wild boar (Sus scrofa leucomystax) meat is one of the most important sources of infection in Japan. We tested 113 serum samples from wild boar captured in Shimonoseki City, Yamaguchi Prefecture, Japan from 2010 to 2012. Serum samples were tested by enzyme-linked immunosorbent assay (ELISA) using virus-like particles as antigen and nested reverse-transcription PCR (RT-PCR). Anti-HEV IgG antibodies were detected in 47 of the 113 wild boar serum samples (42%), and HEV RNA was detected in five samples (4%). Sequence analysis showed that the five HEV isolates belonged to genotype 4, forming a cluster with a previous isolate from a human hepatitis E case in this region in 2011. These results indicate that wild boar in this region are infected with potentially pathogenic HEV at a high prevalence.

  15. Congenital toxoplasmosis in wild boar (Sus scrofa) and identification of the Toxoplasma gondii types involved.

    PubMed

    Calero-Bernal, Rafael; Gómez-Gordo, Luis; Saugar, José María; Frontera, Eva; Pérez-Martín, Juan Enrique; Reina, David; Serrano, Francisco Javier; Fuentes, Isabel

    2013-10-01

    Congenital toxoplasmosis has been little described in wild animals. We report a case of vertical transmission in wild boar (Sus scrofa). Necropsy and histopathologic examination of a pregnant female and her three fetuses revealed all to have lesions compatible with acute toxoplasmosis. Nested polymerase chain reaction B1 gene detected Toxoplasma gondii in maternal (heart and diaphragm) and fetal (central nervous system, retina, optic nerve, heart, lung, tongue, and diaphragm) samples. The mother had a mixed infection of T. gondii types I and III. One fetus with type III infection developed no malformations, but the others-one with type I infection and one infected by types I and III-showed bilateral ocular agenesis, prognathism, and agenesis of the nasal cartilage. These results suggest the pathogenicity of the various T. gondii types may differ in wild boars.

  16. Lead and cadmium in wild boar (Sus scrofa) in the Sierra Nevada Natural Space (southern Spain).

    PubMed

    Mulero, Rocío; Cano-Manuel, Javier; Ráez-Bravo, Arián; Pérez, Jesús M; Espinosa, José; Soriguer, Ramón; Fandos, Paulino; Granados, José E; Romero, Diego

    2016-08-01

    The aims of the present study were to investigate Pb and Cd levels in tissues of wild boar (Sus scrofa) from the Sierra Nevada Natural Space (SNNS) (southern Spain). Heavy metal concentrations in livers, kidneys and bones from 111 animals were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Bones and kidneys were the most Pb- and Cd-contaminated tissues, respectively; Cd concentrations were 5.6 times higher in kidneys than in livers. This is the first biomonitoring study of these pollutants in wild boar tissues in the SNNS, and findings indicate that this population is chronically exposed to these heavy metals. The detected Pb and Cd concentrations were lower than those found in many studies performed in Europe on the same species.

  17. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    PubMed

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution.

  18. The Effect of Clothing on the Rate of Decomposition and Diptera Colonization on Sus scrofa Carcasses.

    PubMed

    Card, Allison; Cross, Peter; Moffatt, Colin; Simmons, Tal

    2015-07-01

    Twenty Sus scrofa carcasses were used to study the effect the presence of clothing had on decomposition rate and colonization locations of Diptera species; 10 unclothed control carcasses were compared to 10 clothed experimental carcasses over 58 days. Data collection occurred at regular accumulated degree day intervals; the level of decomposition as Total Body Score (TBSsurf ), pattern of decomposition, and Diptera present was documented. Results indicated a statistically significant difference in the rate of decomposition, (t427  = 2.59, p = 0.010), with unclothed carcasses decomposing faster than clothed carcasses. However, the overall decomposition rates from each carcass group are too similar to separate when applying a 95% CI, which means that, although statistically significant, from a practical forensic point of view they are not sufficiently dissimilar as to warrant the application of different formulae to estimate the postmortem interval. Further results demonstrated clothing provided blow flies with additional colonization locations.

  19. Seroprevalence of Neospora caninum in feral swine (Sus scrofa) in the United States.

    PubMed

    Cerqueira-Cézar, Camila K; Pedersen, Kerri; Calero-Bernal, Rafael; Kwok, Oliver C; Villena, Isabelle; Dubey, Jitender P

    2016-08-15

    The protozoon Neospora caninum is a major cause of abortion in cattle worldwide. Canids (Canis familiaris, Canis latrans, Canis lupus) are definitive hosts whereas many other animal species, including pigs, are intermediate hosts for the parasite. Between 2012 and 2014, serum samples from 1059 feral swine (Sus scrofa) from 29 states of the USA were tested for N. caninum antibodies, using the N. caninum agglutination test (NAT). Of these, 159 (15.0%) feral pigs from 21 states tested positive, with a range of titers of 1:25 (cut-off) (n=153), 1:200 (1), 1:400 (1), 1:800 (3) and 1:3200 (1). Results indicate widespread exposure of feral swine to N. caninum infection across the USA.

  20. FATAL CASE OF STREPTOCOCCUS SUIS INFECTION IN A YOUNG WILD BOAR (SUS SCROFA) FROM SOUTHWESTERN SPAIN.

    PubMed

    Risco, David; Fernández-Llario, Pedro; Cuesta, Jesús M; García-Jiménez, Waldo L; Gonçalves, Pilar; Martínez, Remigio; García, Alfredo; Rosales, Rubén; Gómez, Luis; de Mendoza, Javier Hermoso

    2015-06-01

    Streptococcus suis is a recognized pathogen that may cause important diseases in pigs and humans. This microorganism has been repeatedly isolated from wild boar (Sus scrofa). However, its health implications for this wild species are still unknown. This article reports a detailed description of a fatal case of septicemia by S. suis affecting a young wild boar. The affected animal, about 15 days old, was found near death and exhibiting neurologic signs at a wild boar estate in southwestern Spain. Postmortem examination showed generalized congestion, brain hemorrhages and lobular pneumonia. Histopathological evaluation demonstrated the presence of meningitis and encephalitis with marked congestion and suppurative bronchopneumonia. Streptococcus suis serotype 2 isolates exhibiting important virulence factors (extracellular factor, muramidase-released protein, and suylisin) were isolated from the affected animal. This study confirms the presence of potentially virulent and zoonotic strains of S. suis in wild boar from Spain.

  1. Caries, Periodontal Disease, Supernumerary Teeth and Other Dental Disorders in Swedish Wild Boar (Sus scrofa).

    PubMed

    Malmsten, A; Dalin, A-M; Pettersson, A

    2015-07-01

    Between January and December 2013, the dental and periodontal health of 99 Swedish wild boars (Sus scrofa) was investigated. Sampling occurred in conjunction with routine hunting at six large estates in the southern and middle parts of Sweden. All six of the estates use supplemental feeding. The weight of the animals, their sex and their dates of death were noted. Age was estimated using tooth eruption and tooth replacement patterns. The oral cavity was inspected and abnormalities were recorded on a dental chart modified for wild boars. The findings included supernumerary teeth, absence of teeth, mild class II malocclusion, severe tooth wear, periodontitis, calculus, caries, tooth fractures and the presence of enamel defects. Swedish wild boars suffer from different dental lesions and the impact of supplemental feeding on dental and periodontal health is still to be investigated.

  2. Torque teno virus (TTV) is highly prevalent in the European wild boar (Sus scrofa).

    PubMed

    Martínez, Laura; Kekarainen, Tuija; Sibila, Marina; Ruiz-Fons, Francisco; Vidal, Dolors; Gortázar, Christian; Segalés, Joaquim

    2006-12-20

    The present study represents the first survey of Torque teno virus (TTV) prevalence in European wild boar (Sus scrofa). The prevalence of two distinct TTV genogroups in 178 Spanish wild boar sera from different geographic regions, management conditions, gender and age was determined by a nested PCR method. The overall prevalence of TTV genogroups was 84% (58% for genogroup 1 and 66% for genogroup 2), and differences between genogroup prevalence were observed depending on the geographical region analysed. Significantly higher prevalence for TTV genogroup 2 was found in fenced managed wild boar, juvenile animals and females. No other significant differences in TTV genogroup prevalence were observed. The phylogenetic analysis of nucleotide sequences obtained from the untranslated region of selected samples revealed that the same TTV genogroups are infecting wild boar and domestic pig. The results indicate that TTV is apparently ubiquitous in European wild boar populations.

  3. Le stéréorestituteur Kelsh

    USGS Publications Warehouse

    Kelsh, H.T.

    1949-01-01

    Le ste??re??orestituteur Kelsh est un appareil de restitution a?? double projection base?? sur le principe des anaglyphes, comme le Multiplex par exemple, mais il a une plus grande pre??cision que ce dernier, vu que les ne??gatifs sont utilise??s directement pour la restitution, sans que l'on soit oblige?? de les re??duire au pre??alable. Une telle solution devient possible lorsque l'e??chelle de l'image plastique (mode??le) est au moins 7 fois plus grande que celle des cliche??s. L'appareil comprend un support reposant par 4 pieds sur la table a?? dessin. Sa partie supe??rieure porte, par l'interme??diaire de trois vis calantes, un cadre dans lequel les deux chambres de projection sont suspendues. Des leviers de commande, agissant sur les chambres, permettent d'introduire la base, le de??versement et les inclinaisons transversale et longitudinale. Les cliche??s conjugue??s ou des diapositifs sont directement place??s dans les chambres de projection munies d'objectifs. En projetant les deux cliche??s au moyen de couleurs comple??mentaires, l'observateur - muni de lunettes a?? verres colore??s (couleurs comple??mentaires) - observe l'image plastique audessus de la table a?? dessin, l'orientation relative des chambres ayant e??te?? e??tablie au pre??alable. Pour le report des points de l'image plastique sur la minute, l'ope??rateur dispose d'une tablette amovible a?? marque-repe??re lumineuse qu'il de??place a?? la main et dont la hauteur au-dessus de la table a?? dessin peut e??tre commande??e par une molette. Pour e??tablir l'orientation absolue de l'image plastique, il suffit d'incliner convenablement le cadre de suspension a?? l'aide des vis calantes, l'orientation relative n'e??tant pas de??truite par cette ope??ration. Les deux cliche??s sont e??claire??s par des projecteurs munis d'une suspension a?? la cardan et relie??s a?? la tablette de restitution par des tiges te??lescopiques. Moyennant ce dispositif, l'e??clairage est concentre?? sur deux petites re

  4. Le médicament générique au Maroc: le point de vue du consommateur

    PubMed Central

    Zaoui, Sanaa; Hakkou, Farid; Filali, Houda; Khabal, Youssef; Tazi, Illias; Mahmal, Lahoucine

    2013-01-01

    Introduction Le médicament générique est souvent une origine de préjugés négatifs et de méfiance chez les professionnels de santé et les patients. Ceci pourrait être dû à plusieurs facteurs entre autre le manque des connaissances du patient sur ces médicaments. Le but de notre étude était d’évaluer l'information du consommateur sur les médicaments génériques et apprécier leur utilisation de ces médicaments. Méthodes Il s'agit d'une étude transversale réalisée de Janvier à Mars 2010 auprès de 251 sujets. Un questionnaire comprenant dix questions fermées a été utilisé. Les questions concernaient l’évaluation des connaissances sur les médicaments génériques, les sources d'information, le degré de confiance et d'information des patients sur ces médicaments. Une analyse descriptive simple des différentes variables a été réalisée. Résultats Dans notre étude, 126 sujets (50,2%) ont répondu connaître les médicaments génériques. Parmi eux, 52,3% les utilisaient et 67,4% estimaient qu'ils étaient insuffisamment informés sur ces médicaments. Les cadres supérieurs et les étudiants ont représenté la catégorie qui utilisait le plus les médicaments génériques (respectivement dans 40,9% et 25,7%) et qui était la mieux informée (respectivement dans 61,9% et 23,81%). Le faible coût a été la principale motivation d'utilisation du médicament générique (93,9%). Les médias ont représenté la première source d'information (59,5%). Après sensibilisation, 88,8% des sujets qui ne connaissaient pas le médicament générique ont été favorable à son utilisation. Conclusion Une promotion efficace par une politique d'information soutenue auprès des consommateurs et par des mesures incitatrices à la prescription et à la délivrance du générique par les médecins et les pharmaciens, pourront améliorer l'utilisation de ces médicaments dans notre pays. PMID:24009794

  5. Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

    PubMed Central

    Bakolitsa, Constantina; Xu, Qingping; Rife, Christopher L.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chen, Connie; Chiu, Hsiu-Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Farr, Carol L.; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Anna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Krishna, S. Sri; Kumar, Abhinav; Lam, Winnie W.; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Puckett, Christina; Reyes, Ron; Tien, Henry J.; Trame, Christine B.; van den Bedem, Henry; Weekes, Dana; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2010-01-01

    The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex. PMID:20944222

  6. Snow in Castile-León: trends and variability

    NASA Astrophysics Data System (ADS)

    Merino, A.; Campos, L.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The location of Castile and León, inside the Iberian Peninsula, in the Northwestern quadrant, determines, in large measure, the climatic conditions of its territory, granting it very characteristic traits, mostly in the mountainous areas. It is important to note that during a large part of the year, the region is under the influence of Jet Stream, and thus, gives way to very diverse dynamic situations, which turn into different and heterogeneous types of weather. So, in many areas of the region, especially in the most elevated areas, these synoptic and mesoscale situations generate snow precipitation. We should point out that snowfall is one of the principal meteorological risks of Castile and León. Thus, on average, in some mountainous areas there are more than 40 events of snowfall registered annually, with the month of January being the month in which the highest frequency of snowfall appears. The social repercussions of this snowfall are represented in the isolation of places, essentially mountainous, highways being blocked, increase in traffic accidents, etc. As proof of this, it is this type of episode that receives ample coverage by the media, which has a linear relationship with the social perception of risk. As such, the objective of the current work is to analyze the annual trend of days with snow in the different meteorological stations pertaining to AEMET placed in the Community. The period of study is from 1960-2010. Additionally, we have also evaluated trends in annual days of freezing temperature and annual absolute minimum temperature, with the objective of facilitating a meteorological interpretation of the trends obtained on days with snowfall. Finally, the results show that in the majority of stations, a significant negative trend in days with snowfall and annual days with freezing temperatures, and a positive trend in annual absolute minimum temperatures. However, we observed variability in the different regions in the area of study

  7. Cross-Reactivity of Porcine Immunoglobulin A Antibodies with Fecal Immunoglobulins of Wild Boar (Sus scrofa) and Other Animal Species.

    PubMed

    Seo, Sang Won; Yoo, Sung J; Sunwoo, Sunyoung; Hyun, Bang Hun; Lyoo, Young S

    2016-06-01

    Fecal samples obtained from wild boar habitats are useful for the surveillance of diseases in wild boar populations; however, it is difficult to determine the species of origin of feces collected in natural habitats. In this study, a fecal IgA ELISA was evaluated as a method for identifying the porcine species from fecal samples. Both domestic pigs (Sus scrofa domestica) and wild boars (Sus scrofa coreanus) showed significantly higher levels of fecal IgA than other animal species. Additionally, age dependent changes in the level of Ig A in wild boars and domestic pigs were identified; Titers of Ig A were highest in suckling period and lowest in weanling period.

  8. The rôle of planetaria: The Library of Alexandria Planetarium Science Center

    NASA Astrophysics Data System (ADS)

    El-Mitaky, Hoda S.

    2011-06-01

    In ancient times the stars and the Moon were humans' only guide to cross the seas and explore the depths of the deserts. With the use of modern technological gadgets, and the increasingly light pollution, citizens of the world stopped looking at the heavens. How can planetaria play a rôle in reviving public interest in astronomy? How can the beauty of astronomy play a rôle in luring the youth to pursue a career in science? How can astronomy play a rôle in raising public awareness about preserving the environment? Moreover, how can astronomy play a rôle in the dialogue among civilisations?

  9. Le consentement libre et éclairé aux soins en psychiatrie

    PubMed Central

    Neilson, Grainne; Chaimowitz, Gary

    2015-01-01

    Résumé Le patient a le droit d’être informé sur les soins de santé qui lui sont proposés et de participer activement à la prise de décisions relativement à ces soins. Le respect de la dignité et de l’autonomie de la personne passe par le respect de son droit de prendre des décisions à propos de ses soins psychiatriques, notamment de refuser un traitement, pour autant qu’elle soit apte à prendre des décisions. Il importe que le psychiatre connaisse les fondements éthiques du consentement libre et éclairé et les exigences prévues par le droit en cette matière, y compris la jurisprudence. Le consentement n’est pas immuable, pouvant changer avec le temps, au fil de l’évolution des conditions et des circonstances. Par conséquent, le consentement doit être un processus continu.

  10. Le gingembre contre la nausée et les vomissements de la grossesse

    PubMed Central

    Lindblad, Adrienne J.; Koppula, Sudha

    2016-01-01

    Question clinique Le gingembre peut-il traiter la nausée et les vomissements de la grossesse? Résultats Durant le premier trimestre, le gingembre soulagerait la nausée et les vomissements de quelque 4 points sur une échelle de 40 points, ou éliminerait les vomissements chez 1 femme sur 3 au jour 6. L’étude la plus vaste ne laisse croire à aucune hausse des malformations congénitales ou de la mortinatalité, mais les études de moins grande envergure laissent croire le contraire.

  11. Le genre Tunga Jarocki, 1838 (Siphonaptera : Tungidae). I – Taxonomie, phylogénie, écologie, rôle pathogène

    PubMed Central

    Beaucournu, J.-C.; Degeilh, B.; Mergey, T.; Muñoz-Leal, S.; González-Acuña, D.

    2012-01-01

    Pour la première fois, les 12 espèces actuellement décrites dans le genre Tunga sont étudiées sur le plan de la taxonomie et de la répartition. Divers aspects de leur biologie et leur rôle pathogène sont également envisagés, et en particulier leur phylogénie, leur chorologie, leur phénologie, leur sexe-ratio et leurs dermecos. PMID:23193514

  12. Identification and antimicrobial resistance of microflora colonizing feral pig (Sus scrofa) of Brazilian Pantanal.

    PubMed Central

    Lessa, SS; Paes, RCS; Santoro, PN; Mauro, RA; Vieira-da-Motta, O

    2011-01-01

    Antimicrobial resistance of bacteria is a worldwide problem affecting wild life by living with resistant bacteria in the environment. This study presents a discussion of outside factors environment on microflora of feral pigs (Sus scrofa) from Brazilian Pantanal. Animals had samples collected from six different body sites coming from two separated geographic areas, Nhecolandia and Rio Negro regions. With routine biochemical tests and commercial kits 516 bacteria were identified, with 240 Gram-positive, predominantly staphylococci (36) and enterococci (186) strains. Among Gram-negative (GN) bacteria the predominant specimens of Enterobacteriaceae (247) mainly represented by Serratia spp. (105), Escherichia coli (50), and Enterobacter spp. (40) and specimens not identified (7). Antimicrobial susceptibility was tested against 17 drugs by agar diffusion method. Staphylococci were negative to production of enterotoxins and TSST-1, with all strains sensitive towards four drugs and highest resistance toward ampicillin (17%). Enterococci presented the highest sensitivity against vancomycin (98%), ampicillin (94%) and tetracycline (90%), and highest resistance pattern toward oxacillin (99%), clindamycin (83%), and cotrimoxazole (54%). In GN the highest resistance was observed with Serratia marcescens against CFL (98%), AMC (66%) and AMP (60%) and all drugs was most effective against E. coli SUT, TET (100%), AMP, TOB (98%), GEN, CLO (95%), CFO, CIP (93%). The results show a new profile of oxacillin-resistant enterococci from Brazilian feral pigs and suggest a limited residue and spreading of antimicrobials in the environment, possibly because of low anthropogenic impact reflected by the drug susceptibility profile of bacteria isolated. PMID:24031689

  13. Genetic characterization and phylogeography of the wild boar Sus scrofa introduced into Uruguay

    PubMed Central

    García, Graciela; Vergara, Julia; Lombardi, Raúl

    2011-01-01

    The European wild boar Sus scrofa was first introduced into Uruguay, in southern South America during the early decades of the last century. Subsequently, and starting from founder populations, its range spread throughout the country and into the neighbouring Brazilian state Rio Grande do Sul. Due to the subsequent negative impact, it was officially declared a national pest. The main aim in the present study was to provide a more comprehensive scenario of wild boar differentiation in Uruguay, by using mtDNA markers to access the genetic characterization of populations at present undergoing rapid expansion. A high level of haplotype diversity, intermediate levels of nucleotide diversity and considerable population differentiation, were detected among sampled localities throughout major watercourses and catchment dams countrywide. Phylogenetic analysis revealed the existence of two different phylogroups, thereby reflecting two deliberate introduction events forming distantly genetic lineages in local wild boar populations. Our analysis lends support to the hypothesis that the invasive potential of populations emerge from introgressive hybridization with domestic pigs. On taking into account the appreciable differentiation and reduced migration between locales in wild boar populations, management strategies could be effective if each population were to be considered as a single management unit. PMID:21734838

  14. Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus.

    PubMed

    Schwartz, John C; Lefranc, Marie-Paule; Murtaugh, Michael P

    2012-05-01

    We have characterized the organization, complexity, and expression of the porcine (Sus scrofa domestica) immunoglobulin lambda (IGL) light chain locus, which accounts for about half of antibody light chain usage in swine, yet is nearly totally unknown. Twenty-two IGL variable (IGLV) genes were identified that belong to seven subgroups. Nine genes appear to be functional. Eight possess stop codons, frameshifts, or both, and one is missing the V-EXON. Two additional genes are missing an essential cysteine residue and are classified as ORF (open reading frame). The IGLV genes are organized in two distinct clusters, a constant (C)-proximal cluster dominated by genes similar to the human IGLV3 subgroup, and a C-distal cluster dominated by genes most similar to the human IGLV8 and IGLV5 subgroups. Phylogenetic analysis reveals that the porcine IGLV8 subgroup genes have recently expanded, suggesting a particularly effective role in immunity to porcine-specific pathogens. Moreover, expression of IGLV genes is nearly exclusively restricted to the IGLV3 and IGLV8 genes. The constant locus comprises three tandem cassettes comprised of a joining (IGLJ) gene and a constant (IGLC) gene, whereas a fourth downstream IGLJ gene has no corresponding associated IGLC gene. Comparison of individual BACs generated from the same individual revealed polymorphisms in IGLC2 and several IGLV genes, indicating that allelic variation in IGLV further expands the porcine antibody light chain repertoire.

  15. Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2.

    PubMed

    Yu, Yejin; Liu, Xiaoxiao; Zhang, Zheren; Xiao, Yunpeng; Hong, Mei

    2013-08-01

    1. Organic anion transporting polypeptides (OATPs) are a family of transporter proteins that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion of various drugs. Human OATP1A2 has been demonstrated to transport wide spectrum of endogenous and exogenous compounds. Study on OATP1A2 orthologues of other species, however, is still limited. 2. Here, we described the cloning and functional characterization of a member of the OATP/Oatp family member obtained from pig (Sus scrofa) liver. Sequence analysis suggested that it has a high homology with human OATP1A2 and bovine Oatp1a2. Prototypic substrates estrone-3-sulfate (E-3-S) and taurocholic acid were transported by the protein. The transport of these two substrates is pH-dependent, with lower pH showing higher uptake function. Kinetic study showed the transport of these two substrates have a Km of 42.5 ± 12.1 and 33.1 ± 8.7 µM, respectively. Pig Slco1a2 has the highest expression level in the liver, and to a less extend in the brain and small intestine. 3. In conclusion, an OATP member was cloned from pig liver. Sequence analysis and phylogenic study revealed it as an orthologue of human OATP1A2. Its kinetic characteristic for prototypic substrates and organ distribution are similar with that of OATP1A2.

  16. Serologic and molecular survey for hepatitis E virus in wild boar (Sus scrofa) in Central Italy

    PubMed Central

    Mazzei, M.; Nardini, R.; Verin, R.; Forzan, M.; Poli, A.; Tolari, F.

    2015-01-01

    The aim of this study was to further investigate the role of wild boar (Sus scrofa) as a reservoir for hepatitis E virus (HEV). Sixty-four blood and faecal samples collected from wild boar hunted in Central Italy in 2011–2012 were examined by indirect enzyme-linked immunosorbent assay and RT-PCR analysis. Positive RT-PCR samples were further examined by nucleotide sequence determination and subsequent phylogenetic analysis. Thirty-six sera (56.2%) were positive for HEV-specific antibodies, and six (9.4%) faecal samples scored RT-PCR-positive results. Four animals were positive by both enzyme-linked immunosorbent assay and RT-PCR. Phylogenetic analysis showed that the detected wild boar–derived HEV sequences clustered within genotype 3, with similarity to sequences of human origin collected in a nearby area in 2012. Our data confirm that HEV is endemic in the wild boar population in the research area and that these wild animals could play an important role in the epidemiology of HEV infection. PMID:26199731

  17. Neospora caninum exposure in overlapping populations of coyotes (Canis latrans) and feral swine (Sus scrofa).

    PubMed

    Bevins, Sarah; Blizzard, Emily; Bazan, Luis; Whitley, Pat

    2013-10-01

    Limited information exists on Neospora caninum transmission dynamics in wildlife. This coccidian parasite, whose presence can lead to substantial economic losses in cattle operations, requires a canid definitive host for reproduction. We examined exposure in a definitive host, coyotes (Canis latrans), and in overlapping populations of feral swine (Sus scrofa) to determine if spatial proximity between a definitive and incidental host influences the likelihood of parasite exposure. Eighteen percent of coyotes (95% confidence interval [CI] = 14.2-21.8) and 15.8% of feral swine (95% CI = 12.5-19.2) had been exposed to N. caninum, and this is the first report of exposure in US feral swine populations. Analyses suggest that the parasite is present throughout the environment and that exposure is not temporally or spatially linked to antibody-positive coyotes. Antibody-positive feral swine were found in an area where the only definitive host is domestic dogs (Canis familiaris), indicating that wild canids are not required to maintain the parasite in the environment.

  18. Test research on sticking mechanism during hot rolling of SUS 430 ferritic stainless steel

    NASA Astrophysics Data System (ADS)

    Liu, Jun-Xian; Zhang, Yong-Jun; Han, Jing-Tao

    2010-10-01

    The sticking phenomenon during hot rolling of SUS 430 ferritic stainless steel was investigated by means of a two-disc type high-temperature wear tester. The test results indicate that sticking particles on the surfaces of high chromium steel (HiCr) and high-speed steel (HSS) rolls undergo nucleation, growth, and saturation stages. Grooves on the roll surface generated by grinding provide nucleation sites for sticking particles. The number of sticking particles on the HiCr roll surface is greater than that on the HSS roll surface. The average surface roughnesses ( R a) of HiCr and HSS rolls change from 0.502 and 0.493 μm at the initial stage to 0.837 and 0.530 μm at the saturation stage, respectively. The test further proves that the sticking behavior is strongly dependent on roll materials, and the HSS roll is more beneficial to prevent particles sticking compared with the HiCr roll under the same hot-rolling conditions.

  19. Developmental changes affecting lectin binding in the vomeronasal organ of domestic pigs, Sus scrofa.

    PubMed

    Park, Junwoo; Lee, Wonho; Jeong, Chanwoo; Kim, Hwangryong; Taniguchi, Kazumi; Shin, Taekyun

    2012-01-01

    This study investigated the developmental changes of glycoconjugate patterns in the porcine vomeronasal organs (VNOs) and associated glands (Jacobson's glands) from prenatal (9 weeks of gestation) and postnatal (2 days after birth) to the sexually mature stage (6 months old). The VNO of pigs (Sus scrofa) was examined using the following: Dolichos biflorus agglutinin (DBA), Bandeiraea simplicifolia agglutinin isolectin B4 (BSI-B4), Triticum vulgaris agglutinin (WGA), Ulex europaeus agglutinin I (UEA-I), and soybean agglutinin (SBA). At the fetal stage, all lectins examined were detected mainly in the free border of the vomeronasal epithelium, but few (WGA and UEA-I) and or absent in the VNO cell bodies. At the postnatal and sexually mature stages, the reactivity of some lectins, including WGA, UEA-I, DBA and SBA, were shown to increase in the VNO sensory epithelium as well as the free border. The increased reactivity of lectins as development progressed was also observed in Jacobson's gland acini. These findings suggest that binding sites of lectins, including those of WGA, UEA-I, DBA, and SBA, increase during development from fetal to postnatal growth, possibly contributing to the increased ability of chemoreception in the pig.

  20. Shifts in soil biodiversity-A forensic comparison between Sus scrofa domesticus and vegetation decomposition.

    PubMed

    Olakanye, Ayodeji O; Thompson, Tim; Ralebitso-Senior, T Komang

    2015-12-01

    In a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. As a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. For this study, domestic pig (Sus scrofa domesticus) (4g) and grass (Agrostis/Festuca spp) cuttings (4g) were buried (July 2013 to July 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 ml; 50 × 70 cm) with parallel soil only controls. The effects of the two carbon sources were determined by monitoring key environmental factors and changes in soil bacterial (16S rRNA gene) and fungal (18S rRNA gene) biodiversity. Soil pH changes showed statistically significant differences (p<0.05) between the treatments. The measured ecological diversity indices (Shannon-Wiener, HꞋ; Simpson, D; and richness, S) of the 16S rRNA and 18S rRNA gene profiles also revealed differences between the treatments, with bacterial and fungal community dominance recorded in the presence of S. scrofa domesticus and grass trimming decomposition, respectively. In contrast, no statistically significant difference in evenness (p>0.05) was observed between the treatments.

  1. Experimental Salmonella typhi infection in the domestic pig, Sus scrofa domestica.

    PubMed

    Metcalf, E S; Almond, G W; Routh, P A; Horton, J R; Dillman, R C; Orndorff, P E

    2000-08-01

    The domestic pig, Sus scrofa domestica, was examined as a model for typhoid fever, a severe and systemic disease of humans caused by Salmonella typhi. Six pigs were inoculated 1 week post-weaning with approximately 10(10)colony forming units (cfu) of wild type Salmonella typhi strain ISP1820 intranasally and observed for 3 weeks. S. typhi was cultured from the tonsils of 50% of the pigs at necropsy. Cultures from all other organs analysed (ileum, colon, spleen and liver) were negative. No clinical or histopathological signs of disease were observed. Pigs inoculated in parallel with swine-virulent S. choleraesuis all exhibited signs of systemic salmonellosis indicating that the parameters of the experimental infection with S. typhi (e.g. route) were appropriate. Whereas the pig has a gastrointestinal tract that is very similar to humans, our results indicated that the unique features of host and microbe interaction needed to produce typhoid fever were not mimicked in swine. Nevertheless, our observation of tonsillar involvement was consistent with former observations of S. choleraesuis and S. typhimurium infections in swine and supports a role for the tonsil in all porcine salmonella infections.

  2. Snaring to control feral pigs sus scrofa in a remote Hawaiian rain forest

    USGS Publications Warehouse

    Anderson, Stephen J.; Stone, Charles P.

    1993-01-01

    Feral pig Sus scrofa control in Kipahulu Valley, a remote rain forest in Haleakala National Park, Maui, Hawaiian Islands, has been achieved with snares over a 45-month period. Initial pig densities in fenced management units of 6·2 km2 and 7·8 km2were estimated at 6 animals/km2 and 14·3 animals/km2 for the two units, based on population reconstruction from animals killed and aged. During the 45 months of the study, 1978 snares were set, and 1·6 million snare nights were logged. Snare density reached 96/km2 and 200/km2 for the two management units by the end of the study. A mean effort of 43 worker hours/pig was used to remove 53 pigs from the upper management unit, and a mean of 7 worker hours/pig to remove 175 animals from the more densely populated lower unit. Pig activity monitoring along transects provided a good measure of control effectiveness until densities of about 1 pig/km2 were achieved, after which transects became less useful than scouting for determining pig activity.

  3. Genome sequencing reveals fine scale diversification and reticulation history during speciation in Sus

    PubMed Central

    2013-01-01

    Background Elucidating the process of speciation requires an in-depth understanding of the evolutionary history of the species in question. Studies that rely upon a limited number of genetic loci do not always reveal actual evolutionary history, and often confuse inferences related to phylogeny and speciation. Whole-genome data, however, can overcome this issue by providing a nearly unbiased window into the patterns and processes of speciation. In order to reveal the complexity of the speciation process, we sequenced and analyzed the genomes of 10 wild pigs, representing morphologically or geographically well-defined species and subspecies of the genus Sus from insular and mainland Southeast Asia, and one African common warthog. Results Our data highlight the importance of past cyclical climatic fluctuations in facilitating the dispersal and isolation of populations, thus leading to the diversification of suids in one of the most species-rich regions of the world. Moreover, admixture analyses revealed extensive, intra- and inter-specific gene-flow that explains previous conflicting results obtained from a limited number of loci. We show that these multiple episodes of gene-flow resulted from both natural and human-mediated dispersal. Conclusions Our results demonstrate the importance of past climatic fluctuations and human mediated translocations in driving and complicating the process of speciation in island Southeast Asia. This case study demonstrates that genomics is a powerful tool to decipher the evolutionary history of a genus, and reveals the complexity of the process of speciation. PMID:24070215

  4. Immobilization of collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa) with Telazol and xylazine.

    PubMed

    Gabor, T M; Hellgren, E C; Silvy, N J

    1997-01-01

    A 1:1 mg mixture of Telazol and xylazine hydrochloride (100 mg of Telazol and 100 mg of xylazine per ml) was used to immobilize wild collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa); mean (+/-SD) intramuscular dosage rate was 4.73 +/- 0.86 mg/kg and 4.35 +/- 0.68 mg/kg for peccaries (n = 107) and hogs (n = 49), respectively. Mean (+/-SD) induction time (time from injection until complete immobilization) was 4.6 +/- 2.5 minutes for collared peccaries and 4.4 +/- 1.9 for hogs. Peccaries became conscious at 64 +/- 29 minutes and first stood at 92 +/- 33 minutes after initial injection. Hogs became conscious at 54 +/- 26 minutes and first stood at 78 +/- 38 minutes after initial injection. A 1:1 mg mixture of Telazol and xylazine provided an effective and safe method to immobilize both species and provided adequate analgesia and anesthesia for short surgical procedures.

  5. LIMITED ANTIBODY EVIDENCE OF EXPOSURE TO MYCOBACTERIUM BOVIS IN FERAL SWINE (SUS SCROFA) IN THE USA.

    PubMed

    Pedersen, Kerri; Miller, Ryan S; Anderson, Theodore D; Pabilonia, Kristy L; Lewis, Jonathan R; Mihalco, Rebecca L; Gortázar, Christian; Gidlewski, Thomas

    2017-01-01

    Bovine tuberculosis is a chronic disease of cattle ( Bos taurus ) caused by the bacterium Mycobacterium bovis . Efforts have been made in the US to eradicate the disease in cattle, but spillover into wildlife and subsequent spillback have impeded progress in some states. In particular, infection in white-tailed deer ( Odocoileus virginianus ) has been followed by infection in cattle in some Midwestern states. Infection has also been documented in feral swine ( Sus scrofa ) on the Hawaiian island of Molokai and in various European countries, but no large-scale survey of antibody exposure to the bacteria has been conducted in feral swine in the US. We tested 488 sera from feral swine collected near previously documented outbreaks of bovine tuberculosis in cattle and captive cervids, in addition to 2,237 feral swine sera collected across the US from 1 October 2013 to 30 September 2014. While all but one of the samples were antibody negative, the results are important for establishing baseline negative data since feral swine are capable reservoirs and could be implicated in future outbreaks of the disease.

  6. The complete mitochondrial genome of Juema pig Sus scrofa (Suina: Suidae) from southern Gansu.

    PubMed

    Xu, Yan-Yan; Tian, Xiao-Xiao; Chen, Lei-Lei; Pan, Hong-Chun

    2016-09-01

    Juema pig is a kind of rare and special pig which is well adapted to high altitude, cold climate and harsh natural environment. The complete mitochondrial genome of Juema pig Sus scrofa is a circular molecule of 16 532 bp in length, containing 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, and a control region. The A + T content of the overall base composition of H-strand is 60.7% (T: 26.2%; C: 26.0%; A: 34.5%; G: 13.3%). ND4L gene begins with GTG as start codon, ND2, ND3, and ND5 genes begin with ATA as a start codon, and other nine protein-coding genes start with ATG. Cyt b gene is terminated with AGA as stop codon, ND1 and ND2 genes are terminated with TAG as stop codon, COII, COIII, ND3, and ND4 end with T, while ATP6, ATP8, COI, ND4L, ND5, and ND6 end with TAA. In addition, the phylogenetic relationships from neighbor-joining analyses based on the 13 concatenated PCGs indicated (Tylopoda (Suina (Ruminantia (Hippopotamidae, Cetacea)))).

  7. Experimental taphonomy: post-mortem microstructural modifications in Sus scrofa domesticus bone.

    PubMed

    Kontopoulos, Ioannis; Nystrom, Pia; White, Lorraine

    2016-09-01

    Bone is a highly specialised form of hard and rigid connective tissue whose histological structure undergoes post-mortem modifications. In taphonomic research, histological examination of bone thin sections is used to investigate these post-mortem microstructural changes in skeletal tissues. In this study, diagenetic modifications in pig skeletal remains (Sus scrofa domesticus) which were exposed to different taphonomic conditions as part of a long-term, real-time experiment were examined under light microscope (i.e. plain and cross polarized light). This experiment demonstrated that macroscopic appearance and microscopic preservation of bone may significantly differ. Early microbial attack was identified as enlarged osteocyte lacunae that later coalesce to constitute larger foci. Additionally, microscopic preservation of different skeletal elements varied intra-individually, while within bone differential preservation (i.e. proximal versus distal ends) was also observed. However, no specific patterns of early histological attack (e.g. endosteal and periosteal destruction) and no clear relationship between histological preservation and proximity to the abdominal area were detected. Lastly, the presence and composition of protective textiles had a clear effect on bone preservation. This research project, therefore, provided important evidence for the better understanding of the diagenetic processes that occur within bones whilst buried or exposed on the ground surface.

  8. Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain.

    PubMed

    Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F; Wahlberg, Lars U; Mufson, Elliott J

    2017-02-15

    Central cholinergic structures within the brain of the even-toed hoofed Goettingen miniature domestic pig (Sus scrofa domesticus) were evaluated by immunohistochemical visualization of choline acetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) . ChAT-immunoreactive (-ir) perikarya were seen in the olfactory tubercle, striatum, medial septal nucleus, vertical and horizontal limbs of the diagonal band of Broca, and the nucleus basalis of Meynert, medial habenular nucleus, zona incerta, neurosecretory arcuate nucleus, cranial motor nuclei III and IV, Edinger-Westphal nucleus, parabigeminal nucleus, pedunculopontine nucleus, and laterodorsal tegmental nucleus. Cholinergic ChAT-ir neurons were also found within transitional cortical areas (insular, cingulate, and piriform cortices) and hippocampus proper. ChAT-ir fibers were seen throughout the dentate gyrus and hippocampus, in the mediodorsal, laterodorsal, anteroventral, and parateanial thalamic nuclei, the fasciculus retroflexus of Meynert, basolateral and basomedial amygdaloid nuclei, anterior pretectal and interpeduncular nuclei, as well as select laminae of the superior colliculus. Double immunofluorescence demonstrated that virtually all ChAT-ir basal forebrain neurons were also p75(NTR) -positive. The present findings indicate that the central cholinergic system in the miniature pig is similar to other mammalian species. Therefore, the miniature pig may be an appropriate animal model for preclinical studies of neurodegenerative diseases where the cholinergic system is compromised. J. Comp. Neurol. 525:553-573, 2017. © 2016 Wiley Periodicals, Inc.

  9. Isolation and characterization of a novel Rhabdovirus from a wild boar (Sus scrofa) in Japan.

    PubMed

    Sakai, Kouji; Hagiwara, Katsuro; Omatsu, Tsutomu; Hamasaki, Chinami; Kuwata, Ryusei; Shimoda, Hiroshi; Suzuki, Kazuo; Endoh, Daiji; Nagata, Noriyo; Nagai, Makoto; Katayama, Yukie; Oba, Mami; Kurane, Ichiro; Saijo, Masayuki; Morikawa, Shigeru; Mizutani, Tetsuya; Maeda, Ken

    2015-09-30

    A novel rhabdovirus was isolated from the serum of a healthy Japanese wild boar (Sus scrofa leucomystax) and identified using the rapid determination system for viral nucleic acid sequences (RDV), next-generation sequencing, and electron microscopy. The virus was tentatively named wild boar rhabdovirus 1 (WBRV1). Phylogenetic analysis of the entire genome sequence indicated that WBRV1 is closely related to Tupaia rhabdovirus (TRV), which was isolated from cultured cells of hepatocellular carcinoma tissue of tree shrew. TRV has not been assigned to any genus of Rhabdoviridae till date. Analysis of the L gene indicated that WBRV1 belongs to the genus Vesiculovirus. These observations suggest that both TRV and WBRV1 belong to a new genus of Rhabdoviridae. Next-generation genome sequencing of WBRV1 revealed 5 open reading frames of 1329, 765, 627, 1629, and 6336 bases in length. The WBRV1 gene sequences are similar to those of other rhabdoviruses. Epizootiological analysis of a population of wild boars in Wakayama prefecture in Japan indicated that 6.5% were positive for the WBRV1 gene and 52% were positive for WBRV1-neutralizing antibodies. Furthermore, such viral neutralizing antibodies were found in domestic pigs in another prefecture. WBRV1 was inoculated intranasally and intraperitoneally into SCID and BALB/c mice and viral RNA was detected in SCID mice, suggesting that WBRV1 can replicate in immunocompromised mice. These results indicate this novel virus is endemic in wild animals and livestock in Japan.

  10. Analysis of muscle and ovary transcriptome of Sus scrofa: assembly, annotation and marker discovery.

    PubMed

    Nie, Qinghua; Fang, Meixia; Jia, Xinzheng; Zhang, Wei; Zhou, Xiaoning; He, Xiaomei; Zhang, Xiquan

    2011-10-01

    Pig (Sus scrofa) is an important organism for both agricultural and medical purpose. This study aims to investigate the S. scrofa transcriptome by the use of Roche 454 pyrosequencing. We obtained a total of 558 743 and 528 260 reads for the back-leg muscle and ovary tissue each. The overall 1 087 003 reads give rise to 421 767 341 bp total residues averaging 388 bp per read. The de novo assemblies yielded 11 057 contigs and 60 270 singletons for the back-leg muscle, 12 204 contigs and 70 192 singletons for the ovary and 18 938 contigs and 102 361 singletons for combined tissues. The overall GC content of S. scrofa transcriptome is 42.3% for assembled contigs. Alternative splicing was found within 4394 contigs, giving rise to 1267 isogroups or genes. A total of 56 589 transcripts are involved in molecular function (40 916), biological process (38 563), cellular component (35 787) by further gene ontology analyses. Comparison analyses showed that 336 and 553 genes had significant higher expression in the back-leg muscle and ovary each. In addition, we obtained a total of 24 214 single-nucleotide polymorphisms and 11 928 simple sequence repeats. These results contribute to the understanding of the genetic makeup of S. scrofa transcriptome and provide useful information for functional genomic research in future.

  11. Seroprevalence of Toxoplasma gondii in hunted wild boars (Sus scrofa) from southeastern France.

    PubMed

    Roqueplo, Cedric; Blaga, Radu; Jean-Lou, Marie; Vallee, Isabelle; Davoust, Bernard

    2017-01-25

    Toxoplasma gondii (Nicolle et Manceaux, 1908) is an obligate intracellular, parasitic protozoan within the phylum Apicomplexa that causes toxoplasmosis in mammalian hosts (including humans) and birds. Since meat of wild boar, Sus scrofa (Linnaeus), has been demonstrated to be a potential source of human infection, a careful evaluation of the prevalence of infection with T. gondii in hunted animals is needed to protect public health. In the Var area in southeastern France, we performed a spatio-temporal survey in order to investigate the prevalence of IgG antibodies in wild boars shot by hunters in the Canjuers military camp during two subsequent hunting seasons. Of 841 wild boars screened, antibodies (IgG) to T. gondii (modified agglutination test, cut-off 1 : 6) were found in 141 (16.8%) muscle extract samples. A significant association (p < 0.001) was found between positivity and age, but not gender, and hunting districts. The results obtained indicate that consumption of raw or undercooked meat from wild boars carries an important risk of infection with T. gondii. Wild boars may be considered as a bioindicator of parasite circulation in this ecosystem.

  12. In Vitro Study of Caecal and Colon Microbial Fermentation Patterns in Wild Boar (Sus scrofa scrofa).

    PubMed

    Pecka-Kiełb, Ewa; Bujok, Jolanta; Miśta, Dorota; Króliczewska, Bozena; Górecka, Justyna; Zawadzki, Wojciech

    2016-01-01

    The aim of this study was to evaluate wild boar (Sus scrofa scrofa) caecal and colon products of microbial activity including short chain fatty acids (SCFA), ammonia and methane concentrations. The in vitro method was applied to caecal and colon contents after 12 and 24-hour incubation with the substrate (wheat bran), or without any additive (control samples). The pH was also measured in each sample. In samples incubated with the substrate, a lower pH was noted as compared to the control (P < 0.001). In terms of the total SCFA concentration, the hindgut microbial fermentation pattern of wild boar was characterized by a high acetate level, followed by propionate and then butyrate at a ratio of 7:1.5:1. Substrate addition decreased acetate molar proportions (P < 0.001) and increased those of butyrate (P < 0.001) as well as propionate (P < 0.05). The total SCFA level in fresh, unincubated caecal samples (128 mmol/kg) was similar to that in the colon (111 mmol/kg). The ammonia concentrations were at the level of 0.8-1.5 mmol/kg of hindgut content and did not differ between the two investigated hindgut parts. Methanogenesis was also similar in the caecum and colon and after 24h was 2.69 mmol/kg and 2.27 for caecal colon control samples, respectively. The substrate increased total gas production and methane concentration (P < 0.001).

  13. Establishing a DNA identification system for pigs (Sus scrofa) using a multiplex STR amplification.

    PubMed

    Lin, Yu-Chih; Hsieh, Hsing-Mei; Lee, James Chun-I; Hsiao, Chung-Ting; Lin, Der-Yuh; Linacre, Adrian; Tsai, Li-Chin

    2014-03-01

    In this study we establish a novel STR multiplex using 13 tetra-nucleotide STRs and the amelogenin marker for the forensic identification of pigs. The genotypes and allele frequency were generated based on 341 samples from 11 pig breeds in Taiwan. Genetic variation was tested including Na, Ne, Ho, He, F-statistics, PIC, Pm and PE for each STR locus and for each breed. Based upon the 341 samples in this study, the CPm and CPEtrio of the 13 STR loci were 1.31 E-11 and 0.9996 respectively. The CPItrio based on ten family sets ranged from 4.012 E+4 to 4.332 E+6 for paternity test. Validation of the multiplex included: determining the sensitivity of the test, where reproducible full DNA profiles were obtained using an initial template of between 0.25 and 1 ng; a comprehensive range of tissue types generated the same genotype; and the specificity was confirmed as no DNA full profile was generated for any species other than Sus scrofa. Based on the phylogenetic analysis, the European domestic breeds clustered separately from the Asian breeds, as expected, and their hybrids formed unique clades respectively between the clades of Asian and European breeds. Eleven test samples, acting as unknown samples, matched all expected breeds. We demonstrate that this novel 14-plex PCR system is valuable in pig individualization, parentage testing, breed assessment, phylogenetic study and forensic applications.

  14. Exposure of feral swine (Sus scrofa) in the United States to selected pathogens.

    PubMed

    Baroch, John A; Gagnon, Carl A; Lacouture, Sonia; Gottschalk, Marcelo

    2015-01-01

    Feral swine (Sus scrofa) are widely distributed in the United States. In 2011 and 2012, serum samples and tonsils were recovered from 162 and 37 feral swine, respectively, in the US to evaluate exposure to important swine endemic pathogens. Antibodies against porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) were found in 2.5% and 25.3% of tested sera, respectively. Positive serological reactions against Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae have been detected in 19.7% and 69.7% of animals. More than 15% of animals presented antibodies against these 2 pathogens simultaneously. Most animals were also seropositive for Lawsonia intracellularis. Feral swine can also be involved in transmission of zoonotic agents. Almost 50% of animals possessed antibodies against Salmonella. In addition, 94.4% of animals were carriers of Streptococcus suis in their tonsils. In conclusion, feral swine may be considered as a potential reservoir for different endemic diseases in domestic pigs, as well as for important zoonotic agents.

  15. Mitochondrial DNA sequence and phylogenetic evaluation of geographically disparate Sus scrofa breeds.

    PubMed

    Cannon, M V; Brandebourg, T D; Kohn, M C; Ðikić, D; Irwin, M H; Pinkert, C A

    2015-01-01

    Next generation sequencing of mitochondrial DNA (mtDNA) facilitates studies into the metabolic characteristics of production animals and their relation to production traits. Sequence analysis of mtDNA from pure-bred swine with highly disparate production characteristics (Mangalica Blonde, Mangalica Swallow-bellied, Meishan, Turopolje, and Yorkshire) was initiated to evaluate the influence of mtDNA polymorphisms on mitochondrial function. Herein, we report the complete mtDNA sequences of five Sus scrofa breeds and evaluate their position within the phylogeny of domestic swine. Phenotypic traits of Yorkshire, Mangalica Blonde, and Swallow-belly swine are presented to demonstrate their metabolic characteristics. Our data support the division of European and Asian breeds noted previously and confirm European ancestry of Mangalica and Turopolje breeds. Furthermore, mtDNA differences between breeds suggest function-altering changes in proteins involved in oxidative phosphorylation such as ATP synthase 6 (MT-ATP6), cytochrome oxidase I (MT-CO1), cytochrome oxidase III (MT-CO3), and cytochrome b (MT-CYB), supporting the hypothesis that mtDNA polymorphisms contribute to differences in metabolic traits between swine breeds. Our sequence data form the basis for future research into the roles of mtDNA in determining production traits in domestic animals. Additionally, such studies should provide insight into how mtDNA haplotype influences the extreme adiposity observed in Mangalica breeds.

  16. 'Post-mortem examination of the reproductive organs of female wild boars (Sus scrofa) in Sweden'.

    PubMed

    Malmsten, Anna; Jansson, Gunnar; Dalin, Anne-Marie

    2017-03-13

    In recent decades, wild boars (Sus scrofa) have increased in numbers and distribution in Europe. Compared to other wild ungulates of similar body size, wild boars have a high reproductive capacity. To increase the knowledge of wild boar reproduction, the objective of this study was to investigate characteristics of reproductive organs, and to provide information on the occurrence of abnormalities in reproductive organs from free-ranging female wild boars. Between December 2011 and December 2015, reproductive organs from female wild boars (>30 kg body weight), were collected during hunting in four Swedish counties at estates where supplementary feeding was applied. The organs were macroscopically examined and measured. The stage of the reproductive cycle was defined according to the ovarian structures and in relation to uterus characteristics. Observed abnormalities were noted. The results from 569 animals that met the requirements to be included in this study showed significant differences in weight and length of the uterus between the various reproductive stages. Sampling region had significant effect on these differences. Abnormalities in the reproductive organs were present in approximately 10% of the examined animals. The prevalence of abnormalities increased significantly with age and was significantly affected by sampling region.

  17. Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis.

    PubMed

    Vale-Gonçalves, H M; Cabral, J A; Faria, M C; Nunes-Pereira, M; Faria, A S; Veloso, O; Vieira, M L; Paiva-Cardoso, Md N

    2015-07-01

    Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochaetes of the genus Leptospira. The wild boar (Sus scrofa), an important hunting species in Europe, seems to play a significant role in the epidemiological cycle of leptospirosis. A total of 101 serum samples from wild boar hunted in Northern Portugal were analysed for leptospiral antibodies detection by microscopic agglutination test. Sera were collected during hunting seasons (2011-2013) and tested with 17 different pathogenic serovars of Leptospira. Antibodies against nine serovars were detected in 66 (65·4%) of these sera. Serovars Tarassovi and Altodouro exhibited the highest seroreactivity rates (23·8% and 16·8%, respectively), followed by Autumnalis (7·9%) and Bratislava (6·9%). Age and district of origin were found to be risk factors for the presence of leptospiral antibodies in contrast to gender. From a One Health perspective, this study revealed that wild boar should be considered as a potential source of leptospirosis dissemination for humans and animal species (domestic and wild) in shared environments, particularly in the Trás-os-Montes region.

  18. Serologic and molecular survey for hepatitis E virus in wild boar (Sus scrofa) in Central Italy.

    PubMed

    Mazzei, M; Nardini, R; Verin, R; Forzan, M; Poli, A; Tolari, F

    2015-09-01

    The aim of this study was to further investigate the role of wild boar (Sus scrofa) as a reservoir for hepatitis E virus (HEV). Sixty-four blood and faecal samples collected from wild boar hunted in Central Italy in 2011-2012 were examined by indirect enzyme-linked immunosorbent assay and RT-PCR analysis. Positive RT-PCR samples were further examined by nucleotide sequence determination and subsequent phylogenetic analysis. Thirty-six sera (56.2%) were positive for HEV-specific antibodies, and six (9.4%) faecal samples scored RT-PCR-positive results. Four animals were positive by both enzyme-linked immunosorbent assay and RT-PCR. Phylogenetic analysis showed that the detected wild boar-derived HEV sequences clustered within genotype 3, with similarity to sequences of human origin collected in a nearby area in 2012. Our data confirm that HEV is endemic in the wild boar population in the research area and that these wild animals could play an important role in the epidemiology of HEV infection.

  19. Spatiotemporal and Ecological Patterns of Mycobacterium microti Infection in Wild Boar (Sus scrofa).

    PubMed

    Chiari, M; Ferrari, N; Giardiello, D; Avisani, D; Pacciarini, M L; Alborali, L; Zanoni, M; Boniotti, M B

    2016-10-01

    Mycobacterium microti has recently been described as the causative agent of tuberculosis-like lesions in wild boar (Sus scrofa), a reservoir specie of Mycobacterium tuberculosis complex (MTBC) in some European Mediterranean ecosystem. Through a five-year survey on tuberculosis in free-living wild boars, the epidemiological trend of M. microti infections and the host and population risk factors linked with its occurrence were described. Retropharyngeal and mandibular lymph nodes of 3041 hunted wild boars from six different districts were macroscopically inspected. The sex and age of each animal were registered, as well as the animal abundance in each district. Lesions compatible with tuberculosis (190) were collected and analysed using a gyrB PCR-RFLP assay. M. microti was identified directly in 99 tissue samples (Prev = 3.26%; 95% CI: 2.67-3.97%), while neither Mycobacterium bovis, nor other members of the MTBC were detected. The probability of being M. microti positive showed spatio-temporal variability, with 26% of increase of risk of being infected for each year. Moreover, a positive effect of wild boar abundance and age on the prevalence was detected. The generalized increase in the European wild boar population, coupled with its sensitivity to M. microti infection, poses a future concern for the identification and management of MTBC members in wild boar.

  20. Light-absorbing Aerosol Properties in the Kathmandu Valley during SusKat-ABC Field Campaign

    NASA Astrophysics Data System (ADS)

    Kim, S.; Yoon, S.; Kim, J.; Cho, C.; Jung, J.

    2013-12-01

    Light-absorbing aerosols, such as black carbon (BC), are major contributors to the atmospheric heating and the reduction of solar radiation reaching at the earth's surface. In this study, we investigate light-absorption and scattering properties of aerosols (i.e., BC mass concentration, aerosol solar-absorption/scattering efficiency) in the Kathmandu valley during Sustainable atmosphere for the Kathmandu valley (SusKat)-ABC campaign, from December 2012 to February 2013. Kathmandu City is among the most polluted cities in the world. However, there are only few past studies that provide basic understanding of air pollution in the Kathmandu Valley, which is not sufficient for designing effective mitigation measures (e.g., technological, financial, regulatory, legal and political measures, planning strategies). A distinct diurnal variation of BC mass concentration with two high peaks observed during wintertime dry monsoon period. BC mass concentration was found to be maximum around 09:00 and 20:00 local standard time (LST). Increased cars and cooking activities including substantial burning of wood and other biomass in the morning and in the evening contributed to high BC concentration. Low BC concentrations during the daytime can be explain by reduced vehicular movement and cooking activities. Also, the developmements of the boundary layer height and mountain-valley winds in the Kathmandu Valley paly a crucial role in the temproal variation of BC mass concentrations. Detailed radiative effects of light-absorbing aerosols will be presented.

  1. Use of Mobile Testing System PeLe for Developing Language Skills

    ERIC Educational Resources Information Center

    Titova, Svetlana

    2015-01-01

    One of the objectives of this paper is to investigate the pedagogical impact of both the mobile testing system PeLe (Norway, HiST) and the enquiry-based learning approach on language skills development in the context of mobile-assisted learning. The research aims to work out a methodological framework of PeLe implementation into the language…

  2. CoLeMo: A Collaborative Learning Environment for UML Modelling

    ERIC Educational Resources Information Center

    Chen, Weiqin; Pedersen, Roger Heggernes; Pettersen, Oystein

    2006-01-01

    This paper presents the design, implementation, and evaluation of a distributed collaborative UML modelling environment, CoLeMo. CoLeMo is designed for students studying UML modelling. It can also be used as a platform for collaborative design of software. We conducted formative evaluations and a summative evaluation to improve the environment and…

  3. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  4. The NASA-LeRC wind turbine sound prediction code

    NASA Technical Reports Server (NTRS)

    Viterna, L. A.

    1981-01-01

    Since regular operation of the DOE/NASA MOD-1 wind turbine began in October 1979 about 10 nearby households have complained of noise from the machine. Development of the NASA-LeRC with turbine sound prediction code began in May 1980 as part of an effort to understand and reduce the noise generated by MOD-1. Tone sound levels predicted with this code are in generally good agreement with measured data taken in the vicinity MOD-1 wind turbine (less than 2 rotor diameters). Comparison in the far field indicates that propagation effects due to terrain and atmospheric conditions may be amplifying the actual sound levels by about 6 dB. Parametric analysis using the code has shown that the predominant contributions to MOD-1 rotor noise are: (1) the velocity deficit in the wake of the support tower; (2) the high rotor speed; and (3) off column operation.

  5. Design of Multidimensional Shinnar-Le Roux RF Pulses

    PubMed Central

    Ma, Chao; Liang, Zhi-Pei

    2014-01-01

    Purpose To generalize the conventional Shinnar-Le Roux (SLR) method for the design of multidimensional RF pulses. Methods Using echo-planar gradients, the multidimensional RF pulse design problem was converted into a series of 1D polynomial design problems. Each of the 1D polynomial design problems was solved efficiently. B0 inhomogeneity compensation and design of spatial-spectral pulses were also considered. Results The proposed method was used to design 2D excitation and refocusing pulses. The results were validated through Bloch equation simulation and experiments on a 3.0 T scanner. Large-tip-angle, equiripple-error, multidimensional excitation was achieved with ripple levels closely matching the design specifications. Conclusion The conventional SLR method can be extended to design multidimensional RF pulses. The proposed method achieves almost equiripple excitation errors, allows easy control of the tradeoff among design parameters, and is computationally efficient. PMID:24578212

  6. Aerospace Test Facilities at NASA LeRC Plumbrook

    NASA Technical Reports Server (NTRS)

    1992-01-01

    An overview of the facilities and research being conducted at LeRC's Plumbrook field station is given. The video highlights four main structures and explains their uses. The Space Power Facility is the world's largest space environment simulation chamber, where spacebound hardware is tested in simulations of the vacuum and extreme heat and cold of the space plasma environment. This facility was used to prepare Atlas 1 rockets to ferry CRRES into orbit; it will also be used to test space nuclear electric power generation systems. The Spacecraft Propulsion Research Facility allows rocket vehicles to be hot fired in a simulated space environment. In the Cryogenic Propellant Tank Facility, researchers are developing technology for storing and transferring liquid hydrogen in space. There is also a Hypersonic Wind Tunnel which can perform flow tests with winds up to Mach 7.

  7. Dysfonctionnements radio-induits du transport colique chez le rat

    NASA Astrophysics Data System (ADS)

    François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

    1998-04-01

    The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

  8. Neptune's Discovery: Le Verrier, Adams, and the Assignment of Credit

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2011-01-01

    As one of the most significant achievements of 19th century astronomy, the discovery of Neptune has been the subject of a vast literature. A large part of this literature--beginning with the period immediately after the optical discovery in Berlin--has been the obsession with assigning credit to the two men who attempted to calculate the planet's position (and initially this played out against the international rivalry between France and England). Le Verrier and Adams occupied much different positions in the Scientific Establishments of their respective countries; had markedly different personalities; and approached the investigation using different methods. A psychiatrist and historian of astronomy tries to provide some new contexts to the familiar story of the discovery of Neptune, and argues that the personalities of these two men played crucial roles in their approaches to the problem they set themselves and the way others reacted to their stimuli. Adams had features of high-functioning autism, while Le Verrier's domineering, obsessive, orderly personality--though it allowed him to be immensely productive--eventually led to serious difficulties with his peers (and an outright revolt). Though it took extraordinary smarts to calculate the position of Neptune, the discovery required social skills that these men lacked--and thus the process to discovery was more bumbling and adventitious than it might have been. The discovery of Neptune occurred at a moment when astronomy was changing from that of heroic individuals to team collaborations involving multiple experts, and remains an object lesson in the sociological aspects of scientific endeavor.

  9. Juvenile domestic pigs (Sus scrofa domestica) use human-given cues in an object choice task.

    PubMed

    Nawroth, Christian; Ebersbach, Mirjam; von Borell, Eberhard

    2014-05-01

    Research on the comprehension of human-given cues by domesticated as well as non-domesticated species has received considerable attention over the last decade. While several species seem to be capable of utilizing these cues, former work with domestic pigs (Sus scrofa domestica) has shown inconclusive results. In this study, we investigated the use of human-given cues in an object choice task by young domestic pigs (N = 17; 7 weeks of age) who had very limited human contact prior to the experiments. Subjects had to choose between two bowls of which only one was baited with a reward. Over the course of five experiments, pigs were able to use proximal and, with some constraints, also distal pointing cues presented in both a dynamic-sustained and in a momentary manner. When the experimenter was pointing from the incorrect bowl towards the correct one, most of the subjects had problems solving the task-indicating that some form of stimulus/local enhancement affected pigs' decision making. Interestingly, pigs were able to utilize the body and head orientation of a human experimenter to locate the hidden reward but failed to co-orient when head or body orientation of the experimenter was directed into distant space with no bowls present. Control trials ruled out the possibility that other factors (e.g. odour cues) affected subjects' choice behaviour. Learning during experiments played a minor role and only occurred in three out of twelve test conditions. We conclude that domestic pigs, even at a very young age, are skilful in utilizing various human-given cues in an object choice task-raising the question whether pigs only used stimulus/local enhancement and associative learning processes or whether they were able to comprehend the communicative nature of at least some of these cues.

  10. Alkali-labile sites in sperm cells from Sus and Ovis species.

    PubMed

    Cortés-Gutiérrez, Elva I; Dávila-Rodríguez, Martha I; López-Fernández, Carmen; Fernández, José Luis; Gosálvez, Jaime

    2008-06-01

    Constitutive alkali-labile sites (ALSs) have been investigated using a protocol of DNA breakage detection-fluorescence in situ hybridization (DBD-FISH) in sperm cells from Sus domesticus (pig), Ovis gmelini musimon (mouflon) and Ovis aries (sheep). The results were compared with those obtained using leucocytes from the same species. Whole comparative genomic hybridization (W-CGH) showed that most of the constitutive ALSs in somatic and germ line cells in all species examined were constrained to particular repetitive satellite DNA sequences located in the pericentromeric constitutive heterochromatin of each chromosome. However, their relative abundance was different among cells of the same organism (leucocytes/sperm cells), and this trend was not maintained when the different species were compared. Thus, in mouflon, the density of ALSs in leucocytes when compared with that observed in sperm cells indicated abundance of the order of eight times less. In sheep, both leucocytes and sperm cells exhibited a large quantity of ALSs, being of the order of four times more abundant in sperm cells. In the pig genome, leucocytes showed a high abundance of ALSs (of the order of 12 times more that in sperm cells) but only involved the metacentric chromosomes of the karyotype. ALSs were not present in the acrocentric chromosomes. Contrary to mouflon and sheep, ALSs were relatively scarce in sperm cells from pig. These results suggest that ALSs are a transient structural feature in the cells of any organisms and point to a non-universal model of chromatin organization in sperm cells among mammals.

  11. Seasonal effect on sperm messenger RNA profile of domestic swine (Sus Scrofa).

    PubMed

    Yang, C C; Lin, Y S; Hsu, C C; Tsai, M H; Wu, S C; Cheng, W T K

    2010-05-01

    Seasonal infertility is a well-known problem in the modern swine (Sus scrofa) industry. The molecular mechanisms responsible for thermal effects on spermatogenesis are, however, just beginning to be elucidated. The existence of specific messenger RNA (mRNA) remnants contained within freshly ejaculated sperm has been identified in several species. Investigators have obtained differential RNA profiles of infertile men compared with fertile individuals; however, there are limited to the probes, which are mostly derived from nucleic acids of testicular tissues of either human or mice. The objective of this study was to investigate mRNA remnants from ejaculated sperm of the domestic swine and uncover important clues regarding the molecular regulation of spermatogenesis under environmental thermo-impacts. We utilized the remnant mRNA collected from swine ejaculated sperm as the target source to detect the global gene expression in summer and in winter by swine sperm-specific oligonucleotide microarray. Sixty-seven transcripts were differentially expressed with statistical differences between seasons of sperm samples collected, including forty-nine in winter (49/67) and eighteen in summer (18/67). There were only 33 of these transcripts that could be annotated to gene ontology hierarchy with the database of Homo sapiens and their functions mostly were involved in variety of metabolic processes. Moreover, these studies also confirmed that significant differences of gene expression profiles were found in swine sperm when comparisons were made between ejaculates collected during the winter and the summer season under the subtropical area such as Taiwan. Even though most of the genes found in our experiments are still poorly understood in terms of their true functions in spermatogenesis, bioinformatics analysis suggested that they are involved in a broad spectrum of biochemical processes including gamete generation. These concordant profiles should permit the development of a

  12. Helminth Parasites of Wild Boars, Sus scrofa, in Bushehr Province, Southwestern Iran

    PubMed Central

    MANSOURI, Majid; SARKARI, Bahador; MOWLAVI, Gholam Reza

    2016-01-01

    Background: Wild boars, Sus scrofa, of wide distribution considered as a potential source of zoonotic parasites. The current study aimed to assess the prevalence of helminth infections in wild boars in the Persian Gulf coastal area (Bushehr Province), Southwestern Iran. Methods: Twenty-five wild boars, including 11 males and 14 females, were collected during a course of vertebrate pest control in the Bushehr Province, southwestern Iran in 2013. The specimen were immediately dissected and carefully searched for the parasites. During necropsy, each organ was examined macroscopically for presence of any helminthic agents. Tissue samples were taken from each organ. Moreover, samples were taken from the content of digestive system. Blood samples were also collected from each boar. All the samples were evaluated for helminth infections by parasitological methods. Results: Twenty-two (88%) of the wild boars were infected with at least one helminth. Out of 25 wild boars, 1 (4%) were infected with Cysticercus tenuicollis, the larval stage of Taenia hydatigena, 13 (52%) with Macracanthorhynchus hirudinaceus, 17 (68%) with Metastrongylus spp, and 20 (80%) with Ascarops spp. Hydatid cyst was detected in the lung of one of the wild boars. No Trichinella spp. larvae were detected in any of the tissues of the animals when evaluated by artificial digestion method. In addition, no contamination with microfilaria was detected in any of animals when the blood samples were tested with Knott’s method. Conclusion: Wild boars are contaminated by some helminthes including zoonotic ones. These animals could be involved in the epidemiology of zoonotic helminth by acting as reservoir hosts. This in turn may bring potential risk for locals and residents of the Bushehr Province, Southwestern Iran. PMID:28127344

  13. The nuclear DNA longevity in cryopreserved boar spermatozoa assessed using the Sperm-Sus-Halomax.

    PubMed

    Alkmin, Diego V; Martinez-Alborcia, Maria J; Parrilla, Inmaculada; Vazquez, Juan M; Martinez, Emilio A; Roca, Jordi

    2013-06-01

    The aim of this experimental study was to evaluate the dynamics of nuclear DNA fragmentation in frozen-thawed (FT) boar spermatozoa incubated over time. Using the Sperm Chromatin Dispersion test (Sperm-Sus-Halomax), this study focused special attention on resolving the hypothesis that the original halo shapes around the sperm head could show dynamic changes over the postthawing incubation time. Twenty FT sperm samples from five boars (four per boar) were incubated at 37 °C during 168 hours and sperm motility (assessed using computer-assisted sperm analysis), viability (evaluated using the LIVE/DEAD Sperm Viability Kit), and nuclear DNA fragmentation were analyzed at 0, 0.5, 2, 4, 6, 24, 48, 72, and 168 hours. The percentages of motile and viable spermatozoa progressively decreased during incubation, with no motile and viable spermatozoa less than 10% in all boars at 24 hours of incubation. Four different halo shapes around the sperm head were considered in the Sperm Chromatin Dispersion test: normal, small, large scattered (typical fragmented nuclear DNA), and absent halo, all of them coexisting at the same time in the boar FT semen samples. Sperm with a large scattered halo did not change during postthaw, consistently showing percentages less than 5% over time in all boars. In contrast, the other three sperm populations showed a dynamic evolution over incubation time, characterized by a gradual reduction of sperm with normal halo, proportional to the increment in the sperm showing a small halo, followed by a switch between the sperm with a small halo and sperm with no halo. These results suggest that three of these four sperm populations, those showing small, large scattered, and absent halo, represent spermatozoa with different degrees of nuclear DNA damage, which should be taken into consideration to indicate the percentage of sperm with fragmented nuclear DNA in boar FT semen samples.

  14. Vaccination of pigs reduces Torque teno sus virus viremia during natural infection.

    PubMed

    Jiménez-Melsió, Alexandra; Rodriguez, Fernando; Darji, Ayub; Segalés, Joaquim; Cornelissen-Keijsers, Vivian; van den Born, Erwin; Kekarainen, Tuija

    2015-07-09

    Anelloviruses are a group of single-stranded circular DNA viruses infecting several vertebrate species. Four species have been found to infect swine, namely Torque teno sus virus (TTSuV) 1a and 1b (TTSuV1a, TTSuV1b; genus Iotatorquevirus), TTSuVk2a and TTSuVk2b (genus Kappatorquevirus). TTSuV infection in pigs is distributed worldwide, and is characterized by a persistent viremia. However, the real impact, if any, on the pig health is still under debate. In the present study, the impact of pig immunization on TTSuVk2a loads was evaluated. For this, three-week old conventional pigs were primed with DNA vaccines encoding the ORF2 gene and the ORF1-A, ORF1-B, and ORF1-C splicing variants and boosted with purified ORF1-A and ORF2 Escherichia coli proteins, while another group served as unvaccinated control animals, and the viral load dynamics during natural infection was observed. Immunization led to delayed onset of TTSuVk2a infection and at the end of the study when the animals were 15 weeks of age, a number of animals in the immunized group had cleared the TTSuVk2a viremia, which was not the case in the control group. This study demonstrated for the first time that TTSuV viremia can be controlled by a combined DNA and protein immunization, especially apparent two weeks after the first DNA immunization before seroconversion was observed. Further studies are needed to understand the mechanisms behind this and its impact for pig producers.

  15. Genetic structure of wild boar (Sus scrofa) populations from East Asia based on microsatellite loci analyses

    PubMed Central

    2014-01-01

    Background Wild boar, Sus scrofa, is an extant wild ancestor of the domestic pig as an agro-economically important mammal. Wild boar has a worldwide distribution with its geographic origin in Southeast Asia, but genetic diversity and genetic structure of wild boar in East Asia are poorly understood. To characterize the pattern and amount of genetic variation and population structure of wild boar in East Asia, we genotyped and analyzed microsatellite loci for a total of 238 wild boar specimens from ten locations across six countries in East and Southeast Asia. Results Our data indicated that wild boar populations in East Asia are genetically diverse and structured, showing a significant correlation of genetic distance with geographic distance and implying a low level of gene flow at a regional scale. Bayesian-based clustering analysis was indicative of seven inferred genetic clusters in which wild boars in East Asia are geographically structured. The level of genetic diversity was relatively high in wild boars from Southeast Asia, compared with those from Northeast Asia. This gradient pattern of genetic diversity is consistent with an assumed ancestral population of wild boar in Southeast Asia. Genetic evidences from a relationship tree and structure analysis suggest that wild boar in Jeju Island, South Korea have a distinct genetic background from those in mainland Korea. Conclusions Our results reveal a diverse pattern of genetic diversity and the existence of genetic differentiation among wild boar populations inhabiting East Asia. This study highlights the potential contribution of genetic variation of wild boar to the high genetic diversity of local domestic pigs during domestication in East Asia. PMID:25034725

  16. Characterization of Sus scrofa small non-coding RNAs present in both female and male gonads.

    PubMed

    Kowalczykiewicz, Dorota; Świercz, Aleksandra; Handschuh, Luiza; Leśniak, Katarzyna; Figlerowicz, Marek; Wrzesinski, Jan

    2014-01-01

    Small non-coding RNAs (sncRNAs) are indispensable for proper germ cell development, emphasizing the need for greater elucidation of the mechanisms of germline development and regulation of this process by sncRNAs. We used deep sequencing to characterize three families of small non-coding RNAs (piRNAs, miRNAs, and tRFs) present in Sus scrofa gonads and focused on the small RNA fraction present in both male and female gonads. Although similar numbers of reads were obtained from both types of gonads, the number of unique RNA sequences in the ovaries was several times lower. Of the sequences detected in the testes, 2.6% of piRNAs, 9% of miRNAs, and 10% of tRFs were also present in the ovaries. Notably, the majority of the shared piRNAs mapped to ribosomal RNAs and were derived from clustered loci. In addition, the most abundant miRNAs present in the ovaries and testes are conserved and are involved in many biological processes such as the regulation of homeobox genes, the control of cell proliferation, and carcinogenesis. Unexpectedly, we detected a novel sncRNA type, the tRFs, which are 30-36-nt RNA fragments derived from tRNA molecules, in gonads. Analysis of S. scrofa piRNAs show that testes specific piRNAs are biased for 5' uracil but both testes and ovaries specific piRNAs are not biased for adenine at the 10th nucleotide position. These observations indicate that adult porcine piRNAs are predominantly produced by a primary processing pathway or other mechanisms and secondary piRNAs generated by ping-pong mechanism are absent.

  17. Clean Technique for Prolonged Nonsurvival Cardiothoracic Surgery in Swine (Sus scrofa)

    PubMed Central

    Chan, Maia M; Rabkin, David G; Washington, Ida M

    2013-01-01

    Laboratory animal regulations provide little guidance regarding duration of nonsurvival surgery requiring aseptic technique. We hypothesized that swine would experience no sepsis during nonsurvival cardiothoracic surgery accomplished by using clean technique and lasting 8 h or less. Incision sites of 5 male farm pigs (Sus scrofa) were shaved and then cleaned with alcohol and povidone–iodine. The surgeon wore sterile gloves, clean scrubs, and hair bonnet; assistants wore clean scrubs and nonsterile gloves; most instruments were autoclaved. A median sternotomy incision was used for thoracic cavity exposure, and the skull was exposed to allow induction of brain death. Heart rate, body temperature, and blood samples were obtained before surgery (0 h; baseline) and at 2, 4, 5 or 6, and 7 or 8 h thereafter. Statistical analysis by t tests showed that heart rate was unchanged and body temperature increased after the 0-h (baseline) time point. Aerobic blood cultures were negative except for 2 samples that were positive for coagulase-negative Staphylococcus spp. at 4 h. RBC, Hgb, and Hct levels were decreased at 2 and 4 h, but WBC and platelets were unchanged. Other alterations included decreased glucose (at 7 or 8 h), increased BUN (at 5 or 6 h and 7 or 8 h) and creatinine (at 5 or 6 h), decreased Na+ and Ca and increased K+ (most time points), decreased total protein and albumin (most time points), and decreased globulin (at 7 or 8 h). Liver enzymes and bilirubin typically were unchanged, and cholesterol consistently was decreased. Together our results indicate a lack of sepsis for 8 h or less in pigs undergoing cardiothoracic surgery by using clean technique. These findings provide new and specific data regarding the use of aseptic technique during prolonged nonsurvival surgeries. PMID:23562035

  18. Les fluctuations supraconductrices dans le compose praseodyme-cerium-oxyde de cuivre

    NASA Astrophysics Data System (ADS)

    Renaud, Jacques

    Ce travail etudie les fluctuations supraconductrices dans le compose supraconducteur a haute temperature critique dope aux electrons Pr2-xCe xCuO4+delta. La technique utilisee pour sonder ces fluctuations est le transport electrique DC dans le plan ab. Il s'agit, a notre connaissance, de la premiere etude de ce type dans la classe generale des supraconducteurs a haute temperature critique dopes aux electrons et, plus particulierement, dans Pr2-xCe xCuO4+delta. De plus, l'etude est effectuee pour trois regimes de dopage, soit sous-dope x = 0.135, dopage optimal x = 0.15 et surdope x = 0.17. Les echantillons etudies sont des couches minces d'epaisseur plus grande que 100 nm crues par ablation laser. Les mesures electriques DC effectuees dans ce travail sont la resistance en reponse lineaire et les courbes IV en reponse non lineaire en fonction de la temperature. La mise en oeuvre experimentale de ces mesures a necessite une grande attention au filtrage et aux effets de chauffage a haut courant. Nous montrons que, sans cette attention, les donnees experimentales sont toujours erronees dans le regime pertinent pour nos echantillons. Les resultats pour le dopage optimal x = 0.15 sont expliques de facon tres convaincante dans le cadre de fluctuations purement 2D. D'abord, le regime des fluctuations gaussiennes est tres bien decrit par le modele d'Aslamazov-Larkin en deux dimensions. Ensuite, le regime de fluctuations critiques, se trouvant a plus basse temperature que le regime gaussien, est tres bien decrit par la physique 2D de Kosterlitz-Thouless. Dans cette analyse, les deux regimes ont des temperatures critiques coherentes entre elles, ce qui semble confirmer ce scenario 2D. Une analyse des donnees dans le cadre de fluctuations 3D est exploree mais donne des conclusions incoherentes. Les resultats pour les autres dopages sont qualitativement equivalents avec le dopage optimal et permettent donc une explication purement 2D. Par contre, contrairement au dopage optimal

  19. Overexpression of the tomato pollen receptor kinase LePRK1 rewires pollen tube growth to a blebbling mode

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP...

  20. Cross-Reactivity of Porcine Immunoglobulin A Antibodies with Fecal Immunoglobulins of Wild Boar (Sus scrofa) and Other Animal Species

    PubMed Central

    Seo, Sang won; Yoo, Sung J.; Sunwoo, Sunyoung; Hyun, Bang hun

    2016-01-01

    Fecal samples obtained from wild boar habitats are useful for the surveillance of diseases in wild boar populations; however, it is difficult to determine the species of origin of feces collected in natural habitats. In this study, a fecal IgA ELISA was evaluated as a method for identifying the porcine species from fecal samples. Both domestic pigs (Sus scrofa domestica) and wild boars (Sus scrofa coreanus) showed significantly higher levels of fecal IgA than other animal species. Additionally, age dependent changes in the level of Ig A in wild boars and domestic pigs were identified; Titers of Ig A were highest in suckling period and lowest in weanling period. PMID:27340389

  1. Sodium Thiosulfate Versus Hydroxocobalamin in the Treatment of Acute, Severe Cyanide Induced Cardiotoxicity in a Swine (Sus Scrofa) Model

    DTIC Science & Technology

    2011-09-22

    intoxicated by cyanide develop cardiac-ar.rest or severely low blood pressure. Currently several antidotes exist, but many have severe adverse effects...machine. They were intoxicated with cyanide (infused through the vein) until the blood pressure was low. The animals were assigned to-one of three...IUIVIJ:lt:M Sodium thiosulfate versus hydroxocoba~amin in the treatment of acute, severe cyanide induced cardiotoxicity in a swine (Sus Scrofa)model on

  2. Spondylodiscite granulomateuse: surtout la tuberculose mais ne pas omettre le lymphome

    PubMed Central

    Zinebi, Ali; Rkiouak, Adil; Akhouad, Yousef; Reggad, Ahmed; Kasmy, Zohour; Boudlal, Mostafa; Lho, Abdelhamid Nait; Rabhi, Moncef; Sinaa, Mohamed; Ennibi, Khalid; Chaari, Jilali

    2016-01-01

    Les douleurs lombaires relèvent d'étiologies multiples dont le diagnostic peut être source de grandes difficultés. Le lymphome rachidien primitif est rare et son diagnostic nécessite une biopsie souvent scanoguidée. Un homme de 30 ans, était hospitalisé pour lombalgies inflammatoires évoluant dans un contexte d'altération de l'état général avec à l'examen des douleurs à la palpation des apophyses épineux L2L3, sans syndrome tumoral périphérique. Le bilan biologique montrait un syndrome inflammatoire. Le bilan morphologique était en faveur d'une spondylodiscite. La première biopsie montrait une ostéite granulomateuse. L'aggravation clinique et radiologique sous anti bacillaire a mené à reconsidérer le diagnostic et la deuxième biopsie confirme le diagnostic du lymphome. Le diagnostic de tuberculose osseuse en particulier vertébrale nécessite une confirmation bactériologique et ou histologique pour ne pas méconnaître un lymphome osseux primitif. PMID:28292061

  3. Le nodule nécrotique solitaire du foie: à propos de deux cas

    PubMed Central

    Mzoughi, Zeineb; Slama, Sana Ben; Bacha, Dhouha; Romdhane, Haifa; Bayar, Rached; Sassi, Asma; Lahmar, Ahlem

    2016-01-01

    Les lésions hépatiques nodulaires sont majoritairement tumorales. Le nodule nécrotique solitire du foie est rare. Le diagnostic preopératoire est difficile. Il s'agit d'une femme âgée de 43 ans qui était opérée d'un adénocarcinome du rectum métastatique au foie opéré. Le scanner abdominal de surveillance a révélé un nodule hépatique d'allure métastatique. Le second cas est celui d'un homme de 56 ans, admis pour cholécystectomie avec découverte per-opératoire d'un nodule hépatique. Dans les deux cas, le nodule hépatique était sous capsulaire et a été réséqué. L'examen anatomopathologique posait le diagnostic de nodule nécrotique solitaire du foie. Le nodule nécrotique non spécifique du foie est une lésion qui doit être évoquée, même dans un contexte néoplasique. Une caractérisation par l'imagerie et une ponction biopsie des lésions hépatiques peut être utile. PMID:28292145

  4. [Identification and characterization of intraspecific variability of the sucrose synthase gene Sus4 of potato (Solanum tuberosum)].

    PubMed

    Boris, K V; Ryzhova, N N; Kochieva, E Z

    2011-02-01

    Nucleotide and amino acid variability of fragments of the Sus4 gene encoding the sucrose synthase enzyme was studied in 24 potato cultivars selected in Russia and other countries and differing in starch content in tubers. Both SNPs and indels were detected in a chosen Sus4 gene fragment including the sequence from exon 3 to exon 6 and corresponding to the main part of the sucrose synthase domain. Four types of Sus4 sequences were revealed depending on the presence of an insertion in introns 4 and 5 and of the mononucleotide octamer (T)8 in intron 5. Differentiation of these sequences was confirmed by statistical methods. Sixteen amino acid substitutions were identified in the translated sequence, of which eleven were nonsynonymous. Specific varietal nucleotide and amino acid substitutions were also revealed, which can be used in future for marking potato cultivars/genotypes. No direct associations between the mutational changes and the starch content were found in the potato cultivars studied by us.

  5. Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania

    PubMed Central

    Larson, Greger; Cucchi, Thomas; Fujita, Masakatsu; Matisoo-Smith, Elizabeth; Robins, Judith; Anderson, Atholl; Rolett, Barry; Spriggs, Matthew; Dolman, Gaynor; Kim, Tae-Hun; Thuy, Nguyen Thi Dieu; Randi, Ettore; Doherty, Moira; Due, Rokus Awe; Bollt, Robert; Djubiantono, Tony; Griffin, Bion; Intoh, Michiko; Keane, Emile; Kirch, Patrick; Li, Kuang-Ti; Morwood, Michael; Pedriña, Lolita M.; Piper, Philip J.; Rabett, Ryan J.; Shooter, Peter; Van den Bergh, Gert; West, Eric; Wickler, Stephen; Yuan, Jing; Cooper, Alan; Dobney, Keith

    2007-01-01

    Human settlement of Oceania marked the culmination of a global colonization process that began when humans first left Africa at least 90,000 years ago. The precise origins and dispersal routes of the Austronesian peoples and the associated Lapita culture remain contentious, and numerous disparate models of dispersal (based primarily on linguistic, genetic, and archeological data) have been proposed. Here, through the use of mtDNA from 781 modern and ancient Sus specimens, we provide evidence for an early human-mediated translocation of the Sulawesi warty pig (Sus celebensis) to Flores and Timor and two later separate human-mediated dispersals of domestic pig (Sus scrofa) through Island Southeast Asia into Oceania. Of the later dispersal routes, one is unequivocally associated with the Neolithic (Lapita) and later Polynesian migrations and links modern and archeological Javan, Sumatran, Wallacean, and Oceanic pigs with mainland Southeast Asian S. scrofa. Archeological and genetic evidence shows these pigs were certainly introduced to islands east of the Wallace Line, including New Guinea, and that so-called “wild” pigs within this region are most likely feral descendants of domestic pigs introduced by early agriculturalists. The other later pig dispersal links mainland East Asian pigs to western Micronesia, Taiwan, and the Philippines. These results provide important data with which to test current models for human dispersal in the region. PMID:17360400

  6. Exploring PTX3 expression in Sus scrofa cardiac tissue using RNA sequencing.

    PubMed

    Cabiati, Manuela; Caselli, Chiara; Savelli, Sara; Prescimone, Tommaso; Lionetti, Vincenzo; Giannessi, Daniela; Del Ry, Silvia

    2012-02-10

    The prototypic long pentraxin PTX3 is a novel vascular inflammatory marker sharing similarities with the classic short pentraxin (C-reactive protein). PTX3 is rapidly produced and released by several cell types in response to local inflammation of the cardiovascular system. Plasma PTX3 levels are very low in normal conditions and increase in heart failure (HF) patients with advancing NYHA functional class, but its exact role during HF pathogenetic mechanisms is not yet established. No data about PTX3 cardiac expression in normal and pathological conditions are currently available, either in human or in large-size animals. Of the latter, the pig has a central role in "in vivo" clinical settings but its genome has not been completely sequenced and the PTX3 gene sequence is still lacking. The aim of this study was to sequence the PTX3 in Sus scrofa, whose sequence is not yet present in GenBank. Utilizing our knowledge of this sequence, PTX3 mRNA expression was evaluated in cardiac tissue of normal (n=6) and HF pigs (n=5), obtained from the four chambers. To sequence PTX3 gene in S. scrofa, the high homology between Homo sapiens and S. scrofa was exploited. Pig PTX3 mRNA was sequenced using polymerase chain reaction primers designed from human consensus sequences. The DNA, obtained from different RT-PCR reactions, was sequenced using the Sanger method. S. scrofa PTX3 mRNA, 1-336 bp, was submitted to GenBank (ID: GQ412351). The sequence obtained from pig cardiac tissue shared an 84% sequence identity with human homolog. The presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls (p=0.036 HF right atrium vs. N; p=0.022, HF left ventricle vs. N). Knowledge of the PTX3 sequence could be a useful starting point for future studies devoted to better understanding the specific role of this molecule in the pathogenesis of cardiovascular diseases.

  7. Speech Processing in Realistic Battlefield Environments (Le Traitement de la Parole en Environnement de Combat Realiste)

    DTIC Science & Technology

    2009-04-01

    parole et du langage multilingue commence à être reconnue comme un enjeu important par les organisations internationales civiles et militaires. Par...sur le développement et l’évaluation des applications multilingues de la parole et du langage . Pour stimuler la recherche et l’évaluation, le Groupe...Opérationnel de Recherche sur la Parole et le Langage (IST-031/TG-013) de l’OTAN a collationné des données vocales en environnement de combat. Ces

  8. Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice

    PubMed Central

    Hatch, Robert John; Leinenga, Gerhard

    2016-01-01

    Scanning ultrasound (SUS) is a noninvasive approach that has recently been shown to ameliorate histopathological changes and restore memory functions in an Alzheimer's disease mouse model. Although no overt neuronal damage was reported, the short- and long-term effects of SUS on neuronal excitability and dendritic tree morphology had not been investigated. To address this, we performed patch-clamp recordings from hippocampal CA1 pyramidal neurons in wild-type mice 2 and 24 hours after a single SUS treatment, and one week and 3 months after six weekly SUS treatments, including sham treatments as controls. In both treatment regimes, no changes in CA1 neuronal excitability were observed in SUS-treated neurons when compared to sham-treated neurons at any time-point. For the multiple treatment groups, we also determined the dendritic morphology and spine densities of the neurons from which we had recorded. The apical trees of sham-treated neurons were reduced at the 3 month time-point when compared to one week; however, surprisingly, no longitudinal change was detected in the apical dendritic trees of SUS-treated neurons. In contrast, the length and complexity of the basal dendritic trees were not affected by SUS treatment at either time-point. The apical dendritic spine densities were reduced, independent of the treatment group, at 3 months compared to one week. Collectively, these data suggest that ultrasound can be employed to prevent an age-associated loss of dendritic structure without impairing neuronal excitability. PMID:27727310

  9. [Mr. Wang Le-ting: a master of acupuncture].

    PubMed

    Niu, Xue-Song; Wang, Fan

    2012-11-01

    Mr. WANG Le-ting attaches great importance to accurate differentiation of syndromes, strict selection of acupoints, technique and direction of needle insertion, clear reinforcing and reducing methods after the appearance of needling sensations, proper opportunities of manipulations as well as needle withdrawal techniques, and reasonable application of acupuncture and moxibustion respectively. The above mentioned principles are known as his "5 agreements". He emphasizes that the selection of acupoints should be "in accordance with both the meridians and the accurate location of the points", and "needling sensation is necessary for each point". He holds that the back-shu points of the five-zang organs and Geshu (BL 17) can be adopted for patient with deficiency of qi, blood, yin and yang. In the aspect of acupoint theory, he insists the accurate location of Xuanzhong (GB 39). He also adjusts the locations of Huatuo Jiaji (EX-B 2) points, and finds the location of the new Dubi (ST 35). For easier applications, he divides the functions of acupoints into different schools of qi, blood, cold, heat, deficiency, excess, wind and dampness. And 41 combinations of acupoints are also invented as innovation. He is always strict to his students, instructing and influencing them by his own words and deeds. He is always conscientious and meticulous, which benefit immensely his followers, and remains a lot of precious experiences for the later generations.

  10. Portevin-Le Chatelier effect and Tsallis nonextensive statistics

    NASA Astrophysics Data System (ADS)

    Iliopoulos, A. C.; Nikolaidis, N. S.; Aifantis, E. C.

    2015-11-01

    In this paper, we estimate Tsallis' entropic index q ≡qstat (stat denotes stationary states) for various stress serration time series of Cu-15%Al alloys corresponding to different deformation temperatures and types (A, B, C) of Portevin-Le Chatelier (PLC) bands. Tsallis statistical analysis is also conducted on experimental data derived from correlation diagrams focusing on PLC type C bands' spatial organization at the surface of various specimens. The results concerning the stress serrations analysis reveal the non-Gaussian (Tsallis q-Gaussian), nonextensive, sub-additive, character of the underlying dynamics of the PLC type-A bands (q > 1) indicating dynamics at the edge of chaos, with global long range correlations and power law scaling. Similarly, for PLC type B bands, a Tsallis q-Gaussian, non-extensive, super-additive, statistical profile was found with q < 1, while for the PLC type C bands, a near Boltzmann-Gibbs (BG) statistical character was verified indicating Gaussian dynamics with short (weak) range correlations. Finally, Tsallis q-index for the spatial data of PLC type C bands was found above unity (q > 1) indicating that type C bands are not randomly nucleated in the specimen (e.g. yielding a Gaussian distribution) but there exist spatial coupling and long range deformation correlations in the PLC type C bands spatial localization.

  11. LeMAPK1, LeMAPK2, and LeMAPK3 are associated with nitric oxide-induced defense response against Botrytis cinerea in the Lycopersicon esculentum fruit.

    PubMed

    Zheng, Yanyan; Hong, Hui; Chen, Lin; Li, Jingyuan; Sheng, Jiping; Shen, Lin

    2014-02-12

    Nitric oxide (NO) and mitogen-activated protein kinases (MAPKs) are signal molecules involved in the disease resistance of plants. To investigate the role of tomato MAPKs in the NO-mediated defense response, mature green tomatoes (Lycopersicon esculentum Mill. cv. Qian-xi) were treated with a MAPKs inhibitor (1,4-diamino-2,3-dicyano-1,4-bis(o-amino-phenylmercapto) butadiene (U0126)), NO donor sodium nitroprusside (SNP), and SNP plus U0126. Treatment with U0126 increased the incidence of disease and size of lesion areas in the tomato fruits after being inoculated with Botrytis cinerea. NO enhanced the resistance of the tomato fruits against Botrytis cinerea invasion and the activities of nitric oxide synthase, Chitinase, β-1,3-glucanase, polyphenol oxidase, and phenylalanine ammonia-lyase. However, the effects of NO on disease resistance were weakened by the MAPKs inhibitor. Meanwhile, the relative expression of LeMAPK1, LeMAPK2, and LeMAPK3 in the (SNP + U0126)-treated fruits was lower than that in the SNP-treated fruits. The results suggest that LeMAPK1/2/3 are involved in NO-induced disease resistance of tomato fruits against Botrytis cinerea.

  12. 3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHEAST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  13. 10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 MANTEL (NOT ORIGINAL) SOUTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  14. 14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, SOUTHEAST BEDROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  15. 7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTH (FRONT) ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  16. 4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  17. Le schwannome malin du nerf grand sciatique chez l'enfant

    PubMed Central

    Lechqar, Maryem; Elbiache, Imad; Atarraf, Karima; Bouabdellah, Youssef; Afifi, My Abderahman

    2012-01-01

    Le schwannome malin est une tumeur très rare chez l'enfant (1 à 2% des tumeurs des tissus mous), elle se développe au dépend des cellules de schwanne. Dans ce travail, les auteurs rapportent un cas de schwannome malin développé au dépend du nerf grand sciatique. La radiographie de la cuisse de face et de profil était normale. L'imagerie par résonance magnétique a identifié une lésion le long du trajet du nerf grand sciatique. La tumeur a été réséquée en totalité emportant le nerf grand sciatique. L'examen anatomo-pathologique a confirmé le diagnostic. PMID:23133710

  18. An Overhead Demonstration of Some Descriptive Chemistry of the Halogens and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Hansen, Robert C.

    1988-01-01

    Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

  19. The Potassium-Argon Laser Experiment (KArLE): In Situ Geochronology for Planetary Missions

    NASA Astrophysics Data System (ADS)

    Cohen, B. A.

    2016-10-01

    KArLE is intended to yield in situ geochronology data and enhance functionality of existing flight instruments using flight hardware that would be reliable, reconfigurable and adaptable to multiple partner instruments and mission architectures.

  20. Landau and Lifshitz' formulation of Le Chatelier's principle: an insight into symbiosis?

    PubMed

    Halabi, T

    2013-12-01

    A correspondence allows application of Landau and Lifshitz' formulation of Le Chatelier's principle from statistical physics to a simple 2-D model of biological symbiosis. The insight: symbionts stabilize the occupation of narrow peaks on fitness landscape.

  1. A Multistep Equilibria-Redox-Complexation Demonstration to Illustrate Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Berger, Tomas G.; Mellon, Edward K.

    1996-01-01

    Describes a process that can be used to illustrate a number of chemical principles including Le Chatelier's principle, redox chemistry, equilibria versus steady state situations, and solubility of species. (JRH)

  2. 5. Former P&LE tracks (now CSXT) adjacent to trestle towards ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Former P&LE tracks (now CSXT) adjacent to trestle towards west. - Monongahela Connecting Railroad Company, Y Trestle, South side of Monongahela River between Thirty-fourth & Twenty-ninth Streets, Pittsburgh, Allegheny County, PA

  3. Facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nguefack-Tsague, Georges; Kalla, Ginette Claude Mireille; Abessolo, Stéphanie Abo'o; Angwafo, Fru; Muna, Walinjom

    2014-01-01

    Introduction L'objectif de ce travail était de déterminer les facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala (Région du Sud) au Cameroun. Méthodes Il s'agissait d'une étude transversale, descriptive et analytique qui s'est déroulée de Février à Mai 2011. Pour cette étude, nous avons obtenu une clairance éthique. Résultats L’échantillon était constitué de 315 participants dont 181 (57,46%) hommes et 134 (42,54%) femmes. L’âge moyen était de 24,5±8ans (extrême: 15-45ans). Quarante personnes (40) étaient séropositifs, soit une prévalence de l'infection par le VIH de 12,7%. Cette prévalence augmentait significativement (p = 0) avec le nombre de partenaires occasionnels au cours des douze derniers mois, allant de 2,7% chez ceux n'ayant eu aucun partenaire occasionnel à 21,25% chez ceux ayant plus de trois partenaires occasionnels (RC = 9,72; IC = 1,27-74,14; P = 0,03). le fait d’être âgé entre 20 et 24 ans (RC = 4,88; IC = 1,74-13,67; p = 0), avoir plus de trois partenaires sexuels au cours des douze derniers mois (RC = 9,72; IC = 1,27-74,14; p = 0,03), avoir les rapports sexuels avec les prostitués (RC = 2,86; IC = 1,42-5,76; p = 0), avoir eu le chlamydia (RC = 3,00; IC = 1,07-8,39; p = 0,04), avoir eu la syphilis (RC = 3,35; IC = 1,57-7,14; p = 0), avoir des avantages sociaux lors du premier rapport sexuel (RC = 2,57; IC = 1,03-6,43; p = 0,04) constituaient des potentiels facteurs de risque du VIH. Conclusion Il apparait urgent d'intensifier les campagnes de sensibilisation au risque d'infection par le VIH et les maladies sexuellement transmissibles dans le district de santé de Meyomessala PMID:25419299

  4. LeČOns Sur Les Ondes De Gravité Des Fluides Incompressibles

    NASA Astrophysics Data System (ADS)

    van den Dungen, F. H.

    Le 3 Janvier 1814 au moment où les Alliés franchissant le Rhin allaient entamer la campagne de France, la classe des Sciences de l'Institut de France proposait comme sujet du grand prix de mathématique à décerner en Janvier 1816 la question suivante: "La théorie de la propagation des ondes à la surface d'un fluide pesant d'une profondeur infinie".

  5. Facteurs déterminants le regret après ligature tubaire

    PubMed Central

    Boufettal, Houssine; Mahdaoui, Sakher; Samouh, Naïma

    2014-01-01

    Introduction La ligature tubaire peut générer regret. Le but de cette étude est d’étudier le vécu après la stérilisation ainsi que le regret et ses facteurs de risque. Méthodes Il s'agit d'une étude rétrospective chez 52 femmes stérilisées entre 2004 et 2010. Résultats Vingt cinq (48%) femmes avaient regretté la réalisation de la ligature tubaire. La moyenne d’âge était de 40,5 ans. Le temps consacré aux explications était très court dans tous les cas. Trois quart des femmes n’était pas au courant des complications de la ligature tubaire. Le regret était dû au facteur religieux (23%), aux algies pelviennes (11,5%), au désir d'autres enfants (9,6%) ou à la prise de connaissance d'autres moyens contraceptifs (3,9%). Conclusion Un certains nombre de facteurs de risque de regret de la ligature tubaire sont retrouvés dans la littérature, comme dans notre série, dont l’âge, le désir de procréer, l'information incomplète, le délai de réflexion et le facteur religieux. PMID:25309644

  6. Le Châtelier reciprocal relations and the mechanical analog

    NASA Astrophysics Data System (ADS)

    Gilmore, Robert

    1983-08-01

    Le Châtelier's principle is discussed carefully in terms of two sets of simple thermodynamic examples. The principle is then formulated quantitatively for general thermodynamic systems. The formulation is in terms of a perturbation-response matrix, the Le Châtelier matrix [L]. Le Châtelier's principle is contained in the diagonal elements of this matrix, all of which exceed one. These matrix elements describe the response of a system to a perturbation of either its extensive or intensive variables. These response ratios are inverses of each other. The Le Châtelier matrix is symmetric, so that a new set of thermodynamic reciprocal relations is derived. This quantitative formulation is illustrated by a single simple example which includes the original examples and shows the reciprocities among them. The assumptions underlying this new quantitative formulation of Le Châtelier's principle are general and applicable to a wide variety of nonthermodynamic systems. Le Châtelier's principle is formulated quantitatively for mechanical systems in static equilibrium, and mechanical examples of this formulation are given.

  7. Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

    NASA Astrophysics Data System (ADS)

    Sendai, Shoichiro

    The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

  8. STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro

    Technology Transfer Automated Retrieval System (TEKTRAN)

    BACKGROUND: LePRK1 and LePRK2 are two pollen receptor kinases localized to the plasma membrane, where they are present in a high molecular weight complex (LePRK complex). LePRK2 is phosphorylated in mature and germinated pollen, but is dephosphorylated when pollen membranes are incubated with tomato...

  9. Intrication de deux atomes en utilisant le blocage de Rydberg

    NASA Astrophysics Data System (ADS)

    Gaëtan, A.

    2010-12-01

    Considérons un système quantique constitué de deux sous-systèmes : on dit qu'il est dans un état intriqué s'il existe des corrélations quantiques entre les états de ces derniers. La compréhension et la mise en œuvre d'états intriqués ont de nombreuses applications (métrologie quantique, étude des systèmes fortement corrélés, traitement quantique de l'information, etc.) et constituent le contexte général de ce travail de thèse. Plus en détail, nous démontrons la réalisation d'un état intriqué de deux atomes neutres piégés indépendamment. Pour cela, nous exploitons le phénomène de blocage de Rydberg : lorsqu'on essaie d'exciter simultanément deux atomes séparés de quelques micromètres vers un état de Rydberg donné, la forte interaction entre atomes de Rydberg peut empêcher cette excitation simultanée. Dans ce cas, seul un des deux atomes est excité et l'on génère ainsi des corrélations quantiques entre les états des deux atomes, c'est-à-dire de l'intrication. Dans notre expérience, deux atomes de 87Rb dans l'état fondamental 5S1/2 sont piégés chacun dans une pince optique microscopique, à une distance relative de 4 micromètres. En réalisant des transitions entre l'état 5S1/2 et l'état de Rydberg 58D3/2 par des transitions à deux photons, nous obtenons un état intriqué des deux atomes dans les sous-niveaux |5S1/2, f = 1, mf = 1> et |5S1/2, f = 2, mf = 2>. Afin de quantifier l'intrication, nous mesurons la fidélité par rapport à l'état-cible en réalisant des transitions Raman entre ces deux sous-niveaux. La fidélité des paires d'atomes présentes à la fin de l'expérience est supérieure à la valeur seuil de 0,5, ce qui prouve la création d'un état intriqué.

  10. SusG: a unique cell-membrane-associated alpha-amylase from a prominent human gut symbiont targets complex starch molecules.

    PubMed

    Koropatkin, Nicole M; Smith, Thomas J

    2010-02-10

    SusG is an alpha-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structure of SusG has an unusual extended, bilobed structure composed of amylase at one end and an unprecedented internal carbohydrate-binding motif at the other. Structural studies further demonstrate that the carbohydrate-binding motif binds maltooligosaccharide distal to, and on the opposite side of, the amylase catalytic site. SusG has an additional starch-binding site on the amylase domain immediately adjacent to the active cleft. Mutagenesis analysis demonstrates that these two additional starch-binding sites appear to play a role in catabolism of insoluble starch. However, elimination of these sites has only a limited effect, suggesting that they may have a more important role in product exchange with other Sus components.

  11. SusG: A Unique Cell-Membrane-Associated [alpha]-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules

    SciTech Connect

    Koropatkin, Nicole M.; Smith, Thomas J.

    2010-09-21

    SusG is an {alpha}-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structure of SusG has an unusual extended, bilobed structure composed of amylase at one end and an unprecedented internal carbohydrate-binding motif at the other. Structural studies further demonstrate that the carbohydrate-binding motif binds maltooligosaccharide distal to, and on the opposite side of, the amylase catalytic site. SusG has an additional starch-binding site on the amylase domain immediately adjacent to the active cleft. Mutagenesis analysis demonstrates that these two additional starch-binding sites appear to play a role in catabolism of insoluble starch. However, elimination of these sites has only a limited effect, suggesting that they may have a more important role in product exchange with other Sus components.

  12. High Prevalence of Co-Infection with Multiple Torque Teno Sus Virus Species in Italian Pig Herds

    PubMed Central

    Blois, Sylvain; Mallus, Francesca; Liciardi, Manuele; Pilo, Cristian; Camboni, Tania; Macera, Lisa; Maggi, Fabrizio; Manzin, Aldo

    2014-01-01

    Torque teno viruses (TTVs) are a large group of vertebrate-infecting small viruses with circular single-stranded DNA, classified in the Anelloviridae family. In swine, two genetically distinct species, Torque teno sus virus 1a (TTSuV1a) and 1b (TTSuV1b) are currently grouped into the genus Iotatorquevirus. More recently, a novel Torque teno sus virus species, named Torque teno sus virus k2b (TTSuVk2b), has been included with Torque teno sus virus k2a (TTSuVk2a) into the genus Kappatorquevirus. In the present study, TTSuV1 (TTSuV1a and TTSuV1b), TTSuVk2a and TTSuVk2b prevalence was evaluated in 721 serum samples of healthy pigs from Sardinian farms, insular Italy. This is the largest study to date on the presence of TTSuV in healthy pigs in Italy. The global prevalence of infection was 83.2% (600/721), being 62.3% (449/721), 60.6% (437/721), and 11.5% (83/721) the prevalence of TTSuV1, TTSuVk2a and TTSuVk2b, respectively. The rate of co-infection with two and/or three species was also calculated, and data show that co-infections were significantly more frequent than infections with single species, and that TTSuV1+TTSuVk2a double infection was the prevalent combination (35.4%). Quantitative results obtained using species-specific real time-qPCR evidenced the highest mean levels of viremia in the TTSuV1 subgroup, and the lowest in the TTSuVk2b subgroup. Interestingly, multiple infections with distinct TTSuV species seemed to significantly affect the DNA load and specifically, data highlighted that double infection with TTSuVk2a increased the viral titers of TTSuV1, likewise the co-infection with TTSuVk2b increased the titers of TTSuVk2a. PMID:25411972

  13. Mechanical transmission of vesicular stomatitis New Jersey virus by Simulium vittatum (Diptera: Simuliidae) to domestic swine (Sus scrofa).

    PubMed

    Smith, Paul F; Howerth, Elizabeth W; Carter, Deborah; Gray, Elmer W; Noblet, Raymond; Mead, Daniel G

    2009-11-01

    Biting flies have been suggested as mechanical vectors of vesicular stomatitis New Jersey Virus (family Rhabdoviridae, genus Vesiculovirus, VSNJV) in livestock populations during epidemic outbreaks in the western United States. We conducted a proof-of-concept study to determine whether biting flies could mechanically transmit VSNJV to livestock by using a black fly, Simulium vittatum Zetterstedt (Diptera: Simuliidae), domestic swine, Sus scrofa L., model. Black flies mechanically transmitted VSNJV to a naive host after interrupted feeding on a vesicular lesion on a previously infected host. Transmission resulted in clinical disease in the naïve host. This is the first demonstration of mechanical transmission of VSNJV to livestock by insects.

  14. New Middle Miocene Bryozoa from Gârbova de Sus (Romania) and their relationship to the sedimentary environment

    NASA Astrophysics Data System (ADS)

    Zágoršek, Kamil; Filipescu, Sorin; Holcová, Katarína

    2010-12-01

    The section of Gârbova de Sus contains diverse fossil groups and rich bryozoan assemblages, with 77 species altogether. Several taxa have been recognized as very important in the assemblage and two new taxa are described in detail: Poricella garbovensis sp. nov. and Therenia transylvanica sp. nov. Foraminifera and calcareous nannofossil assemblages were used for biostratigraphic and paleoenvironmental interpretations. On the basis of sedimentological features and micropaleontological data, the sequence of paleoenvironments can be subdivided into two intervals indicating slightly different climatic conditions.

  15. Lymphome et grossesse: le point de vue de l'obstétricien, à propos de 2 cas

    PubMed Central

    Amourak, Sarah; Alaoui, Fatimazahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    L'association lymphome et grossesse est une situation rare, mais non exceptionnelle, relevant de la coïncidence. Le lymphome vient en 4ème position des cancers rencontrés chez la femme enceinte, La clinique est trompeuse et inconstante, le diagnostic reste histologique et on distingue 2 types: lymphome malin hodgkinien (LMH) et le lymphome malin non hodgkinien (LMNH). Malgré le contexte de véritable urgence hématologique, la décision d'initier ou de différer le traitement est délicate, influencée par le type de lymphome, son extension et sa localisation, la répercussion organique, le degré de maturation f'tale, les risques obstétricaux et les valeurs éthiques, culturelles et religieuses de la patiente. Le traitement consiste essentiellement à une chimiothérapie. Le LH durant la grossesse est relativement moins agressif et d’évolution plus favorable que le LMNH. PMID:25883744

  16. Évolution des lignes directrices sur le traitement de la dyslipidémie

    PubMed Central

    John Bosomworth, N.

    2014-01-01

    Résumé Objectif Comprendre comment les nouvelles lignes directrices sur la prise en charge du risque cardiovasculaire publiées par l’American Heart Association et l’American College of Cardiology (AHA-ACC) peuvent être interprétées et utilisées dans le contexte canadien. Sources des données Les lignes directrices de l’AHA-ACC ont été examinées, de même que toutes les références. Des recherches indépendantes dans PubMed ont été effectuées pour inclure l’ajout aux statines d’autres antihyperlipidémiants et l’emploi de calculatrices médicales visant à aider le patient à comprendre. Message principal Les nouvelles lignes directrices de l’AHA-ACC s’appuient sur les meilleures données probantes disponibles actuellement en matière de traitement de la dyslipidémie. Cela inclut le risque cardiovasculaire (CV) sur 10 ans comme seuil thérapeutique au lieu du taux de cholestérol des lipoprotéines de faible densité, de même que l’abandon des cibles thérapeutiques de lipoprotéines de faible densité. On met de plus en plus l’accent sur les interventions alimentaires et l’exercice, avec l’amorce d’un effort pour quantifier l’effet de ces interventions. Les statines constituent la principale intervention pharmacologique, et l’ajout d’autres médicaments pour accentuer la baisse lipidique n’est plus recommandé. En ce qui concerne l’application au Canada, les tables de risque de Framingham sont plus appropriées pour évaluer le risque que les équations de cohortes regroupées utilisées aux États-Unis. Les calculatrices du risque de maladie cardiovasculaire (MCV) devraient contenir de l’information sur l’âge cardiovasculaire et devraient pouvoir illustrer le risque et les interventions de rechange afin d’aider le patient à comprendre et de favoriser la prise de décision éclairée. Conclusion L’attention sur les meilleures données probantes concernant le risque CV peut simplifier le traitement de la

  17. Sur la reponse en frequence du tissu nerveux dans le cortex

    NASA Astrophysics Data System (ADS)

    Bedard, Claude

    Dans cette These de Physique, nous avons etudie la dependance en frequence du champ electrique du tissu nerveux dans le cortex. Ce champ est aussi designe par "Local field Potential" LFP dans la litterature scientifique. Cette etude est fondee sur la theorie du champ electromagnetisme de Maxwell et sur de l'information tiree de la donne experimentale. Le resultat essentiel de cette These est que la grandeur enorme du temps de relaxation de Maxwell des membranes cellulaires semble etre la cause principale de la dependance en frequence des LFPs. Cette dependance en frequence causee par chaque membrane cellulaire est l'analogue d'un circuit RC ou la resistance R est la resistivite parallele d'une membrane cellulaire, et ou la capacite C est la permittivite electrique de la membrane. L'effet resultant d'un tres grand nombre de cellules donne un spectre de Fourier dont l'enveloppe est tres pres d'un signal en 1/f. Le modele physique propose dans cette These permet de lier les mesures prises a l'interieur d'une dendrite des variations de potentiel electrique a celles prises dans le liquide extracellulaire. De plus, cette These semble ouvrir la possibilite de mesurer le temps de relaxation de Maxwell des membranes cellulaires a l'aide de la mesure de la reponse en frequence du potentiel electrique extracellulaire (LFP). Enfin, cette These permet de lever le voile sur un sujet peu etudie, principalement en raison de la difficulte que represente l'etude des phenomenes electriques dans des milieux complexes comme les tissus vivants. En particulier, le probleme du filtrage frequentiel du potentiel electrique extracellulaire est une propriete fondamentale du tissu nerveux et son origine n'est pas connue.

  18. La plastie en rail dans le traitement des brides rétractiles du creux poplite

    PubMed Central

    Achbouk, A.; Khales, A.; Bourra, K.; Tourabi, K.; Ababou, K.; Ihrai, H.

    2011-01-01

    Summary Les Auteurs décrivent le cas d’un patient âgé de 45 ans atteint de brûlures thermiques par flammes suite à la déflagration d’une bonbonne de gaz. Les lésions initiales intéressaient les quatre membres (en particulier, le genou) et le tronc. La prise en charge initiale a consisté en une excision-greffe précoce des membres. L’évolution a été marquée par la survenue de cicatrices hypertrophiques au niveau des zones non greffées et à la bordure de la greffe ainsi que la survenue de brides rétractiles. Devant l’handicap fonctionnel engendré par la bride à cause de la limitation importante de l’extension, le patient a été admis pour cure chirurgicale. Grâce à la technique en rail décrite, le patient a pu récupérer une fonction normale du genou. Les suites ont été simples avec une durée d’hospitalisation d’un mois. Le résultat esthétique est relativement satisfaisant. La technique en rail est un moyen parmi l’arsenal thérapeutique qui permet de traiter la bride du creux poplité. Sa simplicité, sa facilité technique et son résultat satisfaisant ainsi que ses suites simples permettent de la rendre une technique très prisée dans le traitement de ce type de bride. PMID:21991240

  19. [Research program for the Brazilian Unified Health System (SUS): the contribution to health management and services in Paraiba State, Brazil].

    PubMed

    Celino, Suely Deysny de Matos; Costa, Gabriela Maria Cavalcanti; França, Inácia Sátiro Xavier de; Araújo, Ednaldo Cavalcante de

    2013-01-01

    The shared management in health of the Research Program for the Unified Health System (PPSUS) has the purpose of funding research in priority areas for the health of the Brazilian population. The scope of this qualitative study is to understand the researchers' perception of the contribution of research funded by the PPSUS invitations to bid in the State of Paraiba, for resolving the priority health problems of the Paraiba population, for reducing regional inequalities in health and for bolstering the management of SUS. A documentary survey of the bids and final reports of research and a semi-structured interview with 28 coordinators of these studies was conducted. Triangulation strategy of data was used and subsequently subjected to content analysis, which converged with the categories: solving the health problems; reducing regional inequalities; contribution to management. Paraiba state needs adjustments such that the PPSUS can be fully implemented, ensuring that the knowledge generated can be converted into health policies and actions, since the research funded respond to the health needs of the population and difficulties in SUS management.

  20. Al2O3/SUS304 Brazing via AgCuTi-W Composite as Active Filler

    NASA Astrophysics Data System (ADS)

    Su, Cherng-Yuh; Zhuang, Xie-Zongyang; Pan, Cheng-Tang

    2014-03-01

    Alumina ceramic (α-Al2O3) was brazed to stainless steel (SUS304) using an Ag-Cu-Ti + W composite filler and a traditional active brazing filler alloy (CuSil-ABA). Then, the effects of the presence of W particles and of the brazing parameters on the microstructures and mechanical properties of the brazed joints were investigated. The maximum tensile strength of the joints obtained using Ag-Cu-Ti + W composite filler was 13.2 MPa, which is similar to that obtained using CuSil-ABA filler (13.5 MPa). When the joint was brazed at 930 °C for 30 min, the tensile strengths decreased for both kinds of fillers, although the strength was slightly higher for the Ag-Cu-Ti + W composite filler than for the Ag-Cu-Ti filler. The interfacial microstructure results show that the Ti reacts with W to form a Ti-W-O compound in the brazing alloy. When there are more W particles in the brazing alloy, the thickness of the Ti X O Y reaction layer near the alumina ceramic decreases. Moreover, W particles added to the brazing alloy can reduce the coefficient of thermal expansion of the brazing alloy, which results in lower residual stress between the Al2O3 and SUS304 in the brazing joints and thus yields higher tensile strengths as compared to those obtained using the CuSil-ABA brazing alloy.

  1. THE CHALLENGE OF DETECTING CLASSICAL SWINE FEVER VIRUS CIRCULATION IN WILD BOAR (SUS SCROFA): SIMULATION OF SAMPLING OPTIONS.

    PubMed

    Sonnenburg, Jana; Schulz, Katja; Blome, Sandra; Staubach, Christoph

    2016-10-01

    Classical swine fever (CSF) is one of the most important viral diseases of domestic pigs ( Sus scrofa domesticus) and wild boar ( Sus scrofa ). For at least 4 decades, several European Union member states were confronted with outbreaks among wild boar and, as it had been shown that infected wild boar populations can be a major cause of primary outbreaks in domestic pigs, strict control measures for both species were implemented. To guarantee early detection and to demonstrate freedom from disease, intensive surveillance is carried out based on a hunting bag sample. In this context, virologic investigations play a major role in the early detection of new introductions and in regions immunized with a conventional vaccine. The required financial resources and personnel for reliable testing are often large, and sufficient sample sizes to detect low virus prevalences are difficult to obtain. We conducted a simulation to model the possible impact of changes in sample size and sampling intervals on the probability of CSF virus detection based on a study area of 65 German hunting grounds. A 5-yr period with 4,652 virologic investigations was considered. Results suggest that low prevalences could not be detected with a justifiable effort. The simulation of increased sample sizes per sampling interval showed only a slightly better performance but would be unrealistic in practice, especially outside the main hunting season. Further studies on other approaches such as targeted or risk-based sampling for virus detection in connection with (marker) antibody surveillance are needed.

  2. A cephalometric comparative study of class II correction with Sabbagh Universal Spring (SUS2) and Forsus FRD appliances

    PubMed Central

    Oztoprak, Mehmet Oguz; Nalbantgil, Didem; Uyanlar, Ayhan; Arun, Tulin

    2012-01-01

    Objective The purpose of this clinical prospective study was to compare the dentofacial changes produced by the Sabbagh Universal Spring (SUS2) and Forsus FRD appliances in late adolescent patients with Class II malocclusion, and quantify them in comparison with an untreated group. Method: The study was carried out on 59 patients with skeletal and dental Class II malocclusion due to retrognatic mandible. Among these, 20 were treated with SUS2, 20 were treated with FRD, and no treatment was done to 19 subjects as the control group. 36 cephalometric landmarks were identified on each lateral cephalometric radiograph. Results: The effects of both appliances were dentoalveolar and no significant vertical and sagittal skeletal effect on maxilla and mandible was achieved. The retrusion and extrusion of the maxillary incisors as well as the protrusion and intrusion of mandibular incisors were found to be statistically significant in both treatment groups. Soft tissue profile improvement was limited in both treatment groups. Conclusions: Both appliances corrected Class II discrepancies through dentoalveolar changes; however lower incisor proclination was more prominent with the Forsus FRD. PMID:22904659

  3. LeNRT2.3 functions in nitrate acquisition and long-distance transport in tomato.

    PubMed

    Fu, Yanlei; Yi, Hongying; Bao, Juan; Gong, Jiming

    2015-04-28

    Nitrogen plays an important role in plant growth and development. Nitrate transporters have been extensively studied in Arabidopsis, but in tomato they have not been functionally characterized. In this study, we report the functions of LeNRT2.3 in nitrate transport in tomato. Our results show that LeNRT2.3 is induced by nitrate, and mainly localizes to the plasma membranes of rhizodermal and pericycle cells in roots. Further analysis in Xenopus oocytes showed that LeNRT2.3 mediates low-affinity nitrate transport. 35S:LeNRT2.3 increased nitrate uptake in root and transport from root to shoot. More interestingly, 35S:LeNRT2.3 showed high biomass and fruit weight. Taken together, these results suggest that LeNRT2.3 plays a double role in nitrate uptake and long-distance transport in tomato.

  4. Effets du stress familial lié au diabète sur le contrôle glycémique chez les jeunes diabétiques de type 1

    PubMed Central

    Tsiouli, Elina; Alexopoulos, Evangelos C.; Stefanaki, Charikleia; Darviri, Christina; Chrousos, George P.

    2013-01-01

    Objectif Examiner la façon dont le stress familial influence le contrôle glycémique chez les patients diabétiques de moins de 18 ans. Sources des données Une recherche des études pertinentes publiées depuis 1990 a été réalisée dans PubMed et Scopus à l'aide des mots-clés suivants en anglais: diabetes type 1, glycemic control, family stress, family conflict et family function. Sélection des études La recension initiale a permis de cerner un total de 1 478 articles. La synthèse finale portrait sur 6 études de cohortes, 3 études transversales et 1 étude qualitative dans lesquelles le stress familial était évalué à l'aide d'instruments de mesure des conflits spécifiquement reliés au diabète et le contrôle glycémique était mesuré en fonction de l'hémoglobine glycosylée. Synthèse Dans la plupart des études, il existait une corrélation négative entre le stress familial et le contrôle glycémique des patients. Le bon fonctionnement familial était fortement relié à un bon contrôle glycémique des patients, tandis que les conflits familiaux étaient associés à un mauvais contrôle glycémique. Les familles dont la situation socioéconomique était défavorisée, celles ayant des adolescents atteints de diabète et les familles monoparentales étaient plus enclines à vivre un stress relié au diabète et étaient, par conséquent, plus susceptibles de connaître un moins bon contrôle glycémique. Conclusion Les interventions psychologiques thérapeutiques et les programmes éducatifs peuvent aider à atténuer le stress familial relié au diabète et amélioreront probablement le contrôle glycémique.

  5. Pertinence de l'implantation de la filiere granule de bois pour le Quebec

    NASA Astrophysics Data System (ADS)

    Tremblay, Stephan

    Les spécialistes avancent que le marché mondial de l'énergie en forte demande et en offre limitée nécessitera bientôt toutes les formes d'énergie disponibles. Le granulé de bois est une forme de bioénergie principalement utilisée pour le chauffage des bâtiments et pourrait être davantage considéré dans l'offre énergétique du Québec. Comme le Québec est un territoire où il fait froid et donc susceptible de pouvoir se tourner vers cette forme d'énergie, l'objectif de ce mémoire est d'en analyser les avantages. Pour ce faire, nous commencerons par démontrer la croissance des besoins énergétiques sur les plans national et international et dresser un portrait des différentes formes d'énergies consommées au Québec. Puisque la majorité des Québécois chauffent leurs bâtiments à l'hydroélectricité, nous analyserons à travers le plan d'approvisionnement d'Hydro-Québec le portrait de la production et de la consommation de cette forme d'énergie renouvelable. Cela nous permettra de constater le défi face à la gestion de surplus importants, sauf pendant la période hivernale, et ce faisant, l'obligation de la société d'État d'utiliser davantage ses centrales au gaz ou de se tourner vers l'importation de l'électricité. Dans la même lignée, un regard sera porté sur les perspectives d'utilisation de l'hydroélectricité sur les plans de la production d'aluminium, de l'exportation et de l'utilisation dans l'électrification des transports au Québec. Cette analyse se fera dans l'objectif de s'interroger sur la pertinence d'utiliser cette source d'énergie dans le chauffage plutôt que dans des secteurs plus créateurs de richesse. Nous poserons ensuite l'hypothèse que le granulé de bois pourrait être un bon substitut à une autre forme d'énergie utilisée dans le chauffage, soit le mazout. Avant de dresser un portrait de ce combustible fossile, nous ferons celui de la production et de la consommation de granulés sur les plans r

  6. Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence

    PubMed Central

    Moore, Ainsley; Patterson, Christopher; Lee, Linda; Vedel, Isabelle; Bergman, Howard

    2014-01-01

    Résumé Objectif Revoir les stratégies diagnostiques de la maladie d’Alzheimer, actualiser les recommandations concernant le traitement des symptômes de démence et proposer une approche thérapeutique à la démence d’apparition précoce et d’évolution rapide. Composition du comité Des spécialistes et des délégués de diverses régions du Canada et représentant diverses disciplines pertinentes ont discuté et se sont mis d’accord sur les révisions à apporter aux lignes directrices de 2006. Méthodologie On a eu recours au système GRADE (grading of recommendations, assessment, development, and evaluation) pour évaluer le consensus concernant les recommandations, lequel était défini comme suit : lorsque 80 % ou plus des participants ont voté en faveur de la recommandation. La cote des données probantes est rapportée lorsque cela est possible. Rapport important pour les médecins de famille, malgré les progrès effectués dans les domaines des biomarqueurs liquidiens et de la neuro-imagerie, le diagnostic de démence au Canada demeure fondamentalement clinique. De nouveaux critères cliniques essentiels de diagnostic de la maladie d’Alzheimer en reconnaissent dorénavant les formes moins fréquentes et non amnestiques. La démence précoce, une affection rare, mais importante, devrait inciter les médecins à aiguiller les patients vers un spécialiste ayant accès à des conseillers en génétique. La démence d’évolution rapide, mal définie dans la littérature, faciliterait le dépistage de cette affection rare, mais importante. Les inhibiteurs de la cholinestérase sont maintenant indiqués pour le traitement d’affections autres que la maladie d’Alzheimer. Des lignes directrices concernant l’arrêt du traitement, lesquelles n’existaient pas auparavant, sont également apparues. De nouvelles données probantes sur le recours à la mémantine, aux antidépresseurs et à d’autres agents psychotropes dans le traitement de la

  7. Le modele de Hubbard bidimensionnel a faible couplage: Thermodynamique et phenomenes critiques

    NASA Astrophysics Data System (ADS)

    Roy, Sebastien

    Une etude systematique du modele de Hubbard en deux dimensions a faible couplage a l'aide de la theorie Auto-Coherente a Deux Particules (ACDP) dans le diagramme temperature-dopage-interaction-sauts permet de mettre en evidence l'influence des fluctuations magnetiques sur les proprietes thermodynamiques du systeme electronique sur reseau. Le regime classique renormalise a temperature finie pres du dopage nul est marque par la grandeur de la longueur de correlation de spin comparee a la longueur thermique de de Broglie et est caracterisee par un accroissement drastique de la longueur de correlation de spin. Cette croissance exponentielle a dopage nul marque la presence d'un pic de chaleur specifique en fonction de la temperature a basse temperature. Une temperature de crossover est alors associee a la temperature a laquelle la longueur de correlation de spin est egale a la longueur thermique de de Broglie. C'est a cette temperature caracteristique, ou est observee l'ouverture du pseudogap dans le poids spectral, que se situe le maximum du pic de chaleur specifique. La presence de ce pic a des consequences sur l'evolution du potentiel chimique avec le dopage lorsque l'uniformite thermodynamique est respectee. Les contraintes imposees par les lois de la thermodynamique font en sorte que l'evolution du potentiel chimique avec le dopage est non triviale. On demontre entre autres que le potentiel chimique est proportionnel a la double occupation qui est reliee au moment local. Par ailleurs, une derivation de la fonction de mise a l'echelle de la susceptibilite de spin a frequence nulle au voisinage d'un point critique marque sans equivoque la presence d'un point critique quantique en dopage pour une valeur donnee de l'interaction. Ce point critique, associe a une transition de phase magnetique en fonction du dopage a temperature nulle, induit un comportement non trivial sur les proprietes physiques du systeme a temperature finie. L'approche quantitative ACDP permet de

  8. Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

    NASA Astrophysics Data System (ADS)

    Bourdi, Taoufik

    Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents

  9. Diffusion des macromolécules de dextrane dans le gel Séphadex G-200

    NASA Astrophysics Data System (ADS)

    Moussaoui, M.; Hamieh, T.; Toufaily, J.; Naoufal, D.

    2005-05-01

    Dans cet article nous avons étudié la diffusion des macromolécules de dextrane marquées à l'isothiocyanate de fluorescéine (FITC), dans les perles de l'ultrogel AcA34, par la méthode du retour de la fluorescence après photoblanchiment (FRAP). Le coefficient de partage chromatographique (Kc), a été déterminé par chromatographie sur une colonne de l'ultrogel AcA34. Le coefficient de partage microfluorimétrique (Kf) a été déterminé par la technique de (FRAP), en mesurant à la fois, la fluorescence dans la perle et dans le solvant. La relation entre le coefficient de partage chromatographique et le rayon de Stokes (Rs) des macromolécules a été étudiée en appliquant la relation de Laurent et Killender, alors que la variation du coefficient de diffusion relatif D/D0, a été étudiée en fonction de Kc en appliquant la théorie d'Ogston et al.

  10. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    SciTech Connect

    Riesselmann, A.; Baron, A.; Fregly, M.J. )

    1991-03-11

    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  11. Amphibians and Reptiles of the state of Nuevo León, Mexico

    PubMed Central

    Lemos-Espinal, Julio A.; Smith, Geoffrey R.; Cruz, Alexander

    2016-01-01

    Abstract We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  12. Amphibians and Reptiles of the state of Nuevo León, Mexico.

    PubMed

    Lemos-Espinal, Julio A; Smith, Geoffrey R; Cruz, Alexander

    2016-01-01

    We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed.

  13. Leishmaniose viscerale et leucemie aigüe lymphoblastique B: quel est le rapport?

    PubMed Central

    El Youssi, Hind; Touaoussa, Aziz; Bergui, Imane; Bougrine, Nawal; Amrani, Moncef Hassani

    2015-01-01

    L'association leishmaniose viscérale et leucémie aigue a été rarement rapportée dans la littérature, cependant le diagnostic concomitant de ces deux entités n'a jamais été rapporté au Maroc. Le lien entre ces deux pathologies n'a pas encore été établi et le traitement n'a pas encore été codifié. Nous rapportons le cas d'un garçon de 12 ans chez qui une leishmaniose viscérale et une leucémie aigue lymphoblastique type B ont été diagnostiquées simultanément. Malgré l'administration d'un traitement antiparasitaire associé à une chimiothérapie l’évolution était marquée par le décès du patient. PMID:26090011

  14. Excision and duplication of su3+-transducing fragments carried by bacteriophage phi 80. I. Novel structure of phi 80sus2psu3+ DNA molecule.

    PubMed Central

    Yamagishi, H; Inokuchi, H; Ozeki, H

    1976-01-01

    DNA molecules of phi 80sus2psu3+ and phi 80dsu3+ isolated by Andoh and Ozeki (1968) were studied by the electron microscope heteroduplex method. The phi 80sus2psu3+ and phi 80dsu3+ DNA lengths were found to be 108.7 and 103.3% of the phi 80 DNA, respectively. The phi 80sus2psu3+/phi 80 heteroduplex shows an insertion loop of 8.7% of the phi 80 DNA which migrates from 7.7 to 9.7%, as measured relative to the left (0%) and right (100%) termini of the mature phi 80 DNA molecule. The region of loop migration occupies the central region of the phi 80 head gene cluster. The presence of su3+-containing Escherichia coli DNA of 6.7% phi 80 unit flanked by two homologous regions of phage DNA of 2.0% of phi 80 unit gives rise to a movable insertion loop. In phi 80dsu3+, from which phi 80sus2psu3+ was derived, 50.5% of the phi 80 DNA at the left arm was replaced by E. coli DNA containing the su3+ gene, equivalent to about 53.8% phi 80 unit in length. The phi 80sus2psu3+/phi 80dsu3+ heteroduplex appears as a double-stranded molecule that bifurcates into two clearly visible single-stranded regions, rejoins, bifurcates, and rejoins again. The middle double-stranded stretches of 6.7% phi 80 unit correspond to the E. coli DNA inserted in phi 80sus2psu3+. Therefore the transducing fragment carried by phi 80sus2psu3+ originates from the inside region of the transducing fragment of defective phage phi 80dsu3+ by at least two illegitimate recombination events. Images PMID:1271527

  15. Le naevus bleu cellulaire atypique du poignet: à propos d'un cas et revue de la literature

    PubMed Central

    Boussakri, Hassan; Roux, Jean Luc; Durand, Luc; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2014-01-01

    Le naevus bleu cellulaire atypique est une entité pathologique rare et sa localisation au niveau du poignet est exceptionnelle. Il est Considéré comme une Variante à des caractéristiques intermédiaires entre le naevus bleu cellulaire typique et le naevus bleu malin, dont l’évolution est incertaine. Le but de notre travail est d'attirer l'attention sur cette variété lésionnelle rare et de discuter les diagnostiques différentiels, ainsi que décrire les aspects histologique et les options thérapeutiques possibles. PMID:25426206

  16. Le syndrome d'Othello: un cas observé à Ouagadougou

    PubMed Central

    Kaboré, Bawindsongré Jean; Napon, Christian

    2013-01-01

    Les auteurs rapportent le premier cas de délire de jalousie encore décrit sous l'acronyme de syndrome d'Othello, à Ouagadougou. Il s'est agit d'un patient qui au décours d'un accident vasculaire cérébral ischémique constitué, a développé un délire de jalousie. Une revue de la littérature permet de comprendre que l'affection, rarement rapportée est de plus en plus décrite au décours de maladies neurologiques aigues ou chroniques, et que le lobe frontal joue vraisemblablement un rôle majeur. PMID:24570777

  17. Developmental History of Liquid Oxygen Turbopumps for the LE-7 Engine

    NASA Astrophysics Data System (ADS)

    Kamijo, Kenjiro; Yamada, Hitoshi; Sakazume, Norio; Warashina, Shogo

    The first stage of the H-2 rocket used a 110-ton thrust liquid oxygen, liquid hydrogen, pump-fed engine, the LE-7. This engine required high-pressure and high-power liquid oxygen and liquid hydrogen turbopumps to achieve the two-stage combustion cycle in which the combustion pressure is around 13 MPa. Furthermore, it was very important to operate both turbopumps at higher rotational speeds to obtain a smaller, lighter-weight engine because the LE-7 had not low-speed, low-pressure pumps ahead of both the main pumps. The present paper shows the design, test results, and modifications that had been performed until a flight-type liquid oxygen turbopump for the LE-7 engine was completed. The liquid oxygen turbopump had been developed by the use of three models, that is, research, prototype, and flight models.

  18. à quoi doit servir le patrimoine astronomique français?

    NASA Astrophysics Data System (ADS)

    Caplan, J.; Vila, B.

    2012-12-01

    Les deux auteurs, l'un astronome l'autre botaniste (et chargé de mission patrimoine de l'université d'Aix-Marseille), présentent quelques idées sur la gestion des collections historiques d'astronomie, dans un contexte universitaire. Nous mettons en avant la spécificité de ces collections par rapport à celles des musées traditionnels et leur importance pour l'histoire des sciences notamment. Nous rappelons également la nécessité de suivre la déontologie muséale soutenue par l'association Universeum, réseau européen pour le patrimoine universitaire. Enfin nous rappelons lele essentiel que jouent les réserves et la nécessité de travailler en collaboration.

  19. Quand le bloc axillaire reste la seule alternative chez un enfant de 5 ans

    PubMed Central

    Nakhli, Mohamed Said; Béjaoui, Nawel; Naija, Walid; Mhamdi, Salah; Said, Rachid

    2015-01-01

    Le bloc axillaire par neurostimulation chez l'enfant n'est pas une technique habituelle, surtout avec le développement des techniques d'anesthésie locorégionale échoguidées. Cependant elle peut être une alternative intéressante si l'anesthésie générale est a risque voir même contre indiquée. Nous rapportons le cas d'un bloc axillaire anesthésique chez un enfant de 5 ans porteur d'un kyste hydatique du poumon et une hépatite A sévère proposé pour une fixation de fracture du condyle externe de l'humérus. PMID:26405472

  20. Le Fort I Osteotomy with Bone Grafts in Preprosthetic Surgery: Technical Note

    PubMed Central

    Pingarron-Martin, Lorena; Arias-Gallo, Javier; Ong, Hui Shan; Pons, Manuel Chamorro

    2013-01-01

    Background Being edentulous causes progressive bony resorption in maxillae, which can lead to altered maxillomandibular relationships. Discussion should consider Le Fort I osteotomy with inlay grafts for a better success rate. Thus, this article introduces a technical note in improving the success rate. Case Report The presented technical note permits transformation of the surgery in a conventional Le Fort I with a simple fixation not only of the grafts but also of the osteotomy. The surgical steps are explained as well as the follow-up results. Discussion Adding additional wire anchorage around bone grafts greatly improved our success rate and reduced our operative time. Bone grafting concurrently with Le Fort I osteotomy immediately improved the facial skeletal profile. Several in vitro studies have shown that galvanic corrosion does not play a significant role when combining stainless steel and titanium. Our novel technique is relatively simple and can be easily picked up by young surgeons. PMID:24436751

  1. Le conflit fémoro-acétabulaire et la coxarthrose

    PubMed Central

    Zhang, Charlie; Li, Linda; Forster, Bruce B.; Kopec, Jacek A.; Ratzlaff, Charles; Halai, Lalji; Cibere, Jolanda; Esdaile, John M.

    2015-01-01

    Objectif Expliquer la présentation clinique, les observations à l’examen physique, les critères diagnostiques et les options de prise en charge du conflit fémoroacétabulaire (CFA). Sources des données Une recherche documentaire a été effectuée dans PubMed pour trouver des articles pertinents sur la pathogenèse, le diagnostic, le traitement et le pronostic du CFA. Message principal Depuis les dernières années, on reconnaît de plus en plus que le CFA est un précurseur potentiel et une étiologie importante des douleurs à la hanche dans la population adulte et de la coxarthrose idiopathique plus tard dans la vie. Le conflit fémoro-acétabulaire désigne un ensemble d’anomalies morphologiques osseuses de l’articulation de la hanche qui se traduit par un contact anormal durant le mouvement. Le CFA par effet came concerne une proéminence osseuse non sphérique du col fémoral proximal ou de la jonction tête-col. Le CFM par effet tenaille désigne une couverture acétabulaire excessive par-dessus la tête du fémur, qui peut se produire en raison de diverses variantes morphologiques. Les patients qui ont un CFA présentent une douleur inguinale antérieure chronique, profonde ou lancinante, le plus souvent en position assise, durant ou après une activité. Les patients peuvent aussi ressentir des douleurs occasionnelles aiguës durant l’activité. Il faut procéder à une anamnèse approfondie portant notamment sur l’incidence de traumatismes ou la fréquence de l’exercice. Il faut aussi faire un examen physique complet des hanches, de la région lombaire et de l’abdomen pour évaluer d’autres causes de douleurs inguinales antérieures. Le diagnostic de CFA est confirmé par radiographie. Le conflit fémoro-acétabulaire peut être pris en charge selon une approche conservatrice comportant du repos, la modification des activités, des médicaments et de la physiothérapie ou encore être traité par intervention chirurgicale. Conclusion

  2. Causes de décès des patients infectés par le VIH dans le Centre tunisien

    PubMed Central

    Chelli, Jihène; Bellazreg, Foued; Aouem, Abir; Hattab, Zouhour; Mesmia, Hèla; Lasfar, Nadia Ben; Hachfi, Wissem; Masmoudi, Tasnim; Chakroun, Mohamed; Letaief, Amel

    2016-01-01

    La trithérapie antirétrovirale a contribué à une baisse considérable de la mortalité liée au VIH. Les causes de décès sont dominées par les infections opportunistes dans les pays en voie de développement et par les maladies cardiovasculaires et les cancers dans les pays développés. L’objectif était de déterminer les causes et les facteurs de risque de décès des patients infectés par le VIH dans le Centre Tunisien. Une étude transversale auprès des patients infectés par le VIH âgés de plus de 15 ans suivis à Sousse et à Monastir entre 2000 et 2014. Le décès était considéré lié au VIH si la cause était un évènement classant SIDA ou s’il était la conséquence d’une infection opportuniste d’étiologie indéterminée avec des CD4 < 50/mm3, non lié au VIH si la cause n’était pas un évènement classant SIDA, et de cause inconnue si aucune information n’était disponible. Deux cents treize patients, 130 hommes (61%) et 83 femmes (39%), d’âge moyen 40±11 ans ont été inclus. Cinquante quatre patients sont décédés, avec une mortalité de 5,4/100 patients-années. La mortalité annuelle a baissé de 5,8% en 2000-2003 à 2,3% en 2012-2014. La survie était de 72% à 5 ans et de 67% à 10 ans. Les décès étaient liés au VIH dans 70,4% des cas. Les causes de décès les plus fréquentes étaient la pneumocystose pulmonaire et la cryptococcose neuroméningée dans 6 cas (11%) chacune. Les facteurs de risque de décès étaient les antécédents d’infections opportunistes, la durée de la trithérapie antirétrovirale < 12 mois et le tabagisme. Le renforcement du dépistage, l’initiation précoce de la trithérapie antirétrovirale, et la lutte contre le tabagisme sont nécessaires afin de réduire la mortalité chez les patients infectés par le VIH en Tunisie. PMID:28292068

  3. le de la radiothérapie dans le traitement de l'améloblastome: à propos de deux cas

    PubMed Central

    El Mazghi, Abderrahman; Bouhafa, Touria; El Kacemi, Hanan; Loukili, Kaoutar; Chbani, Laila; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Lele de la radiothérapie dans son traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L’évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans. PMID:25722762

  4. Progress on the Development of Two-Dimension Eulerian-Lagrangian Code LeFIX

    SciTech Connect

    Sunchai, Nilsuwankosit; IkKyu, Park; JinHo, Song

    2006-07-01

    In order to improve on the analysis and the simulation of the process of fuel-coolant interaction, a code capable of simulating the motions of the fuel particles and two phases of the fluid is considered. Based on the old two-fluid code called K-FIX and LeSiM, the newly developed set of subroutines to simulate the motion and the interaction of the Lagrangian particles, the new two-dimension two-fluid thermal hydraulic code called LeFIX is being developed. For solving the conservation equations, the algorithm employed by LeFIX was modified from that used in K-FIX. However, since the correlations for liquid-vapor heat transfer coefficients in droplet and bubbly flows together with the drag coefficient between two phases of the fluid in the same flow scheme had not been modeled in KFIX, they were specifically implemented. In addition, the simplified functions specifying the properties of the liquid water and the steam were also introduced. Currently, LeFIX was verified to give the results identical to that of K-FIX when they were run under the condition where each phase of the fluid were incompressible, with constant but very high heat and momentum transfer rates. In this specific work, LeFIX was tested for the condition in which the steam bubbles gradually rose in the cylindrical volume filled with the subcooled liquid water. The obtained results showed that LeFIX could reasonably well simulate the motion by each phase of the fluid and also their interactions. With the models for the fluid being completed, testing the interaction of the two-phase fluid with the Lagrangian particles is to be the next stage of the development. (authors)

  5. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  6. Spargana in a weasel, Mustela sibirica manchurica, and a wild boar, Sus scrofa, from Gangwon-do, Korea.

    PubMed

    Lee, Seung-Ha; Choe, Eun-Yoon; Shin, Hyun-Duk; Seo, Min

    2013-06-01

    To know the status of sparganum (plerocercoid of Spirometra erinacei) infection in the Korean wild life, several species of wild animals were captured in Gangwon-do and examined for their status of infection with spargana. From February to December 2011, a total of 62 wild boars, 5 badgers, 1 weasel, 1 Siberian chipmunk, and 53 wild rodents were captured, and their whole muscles were examined with naked eyes for the presence of spargana worms. From the weasel and 1 wild boar, a total of 5 spargana specimens were extracted. The weasel was for the first time recorded as an intermediate or paratenic/transport host of S. erinacei in Korea, and both the weasel (Mustela sibirica manchurica) and wild boar (Sus scrofa) were added to the list of wild animals carrying spargana.

  7. Helminth parasites of the wild boar, Sus scrofa, in Luristan province, western Iran and their public health significance.

    PubMed

    Solaymani-Mohammadi, S; Mobedi, I; Rezaian, M; Massoud, J; Mohebali, M; Hooshyar, H; Ashrafi, K; Rokni, M B

    2003-09-01

    Seven helminth species were obtained from 12 wild boars (Sus scrofa) during a survey from 2000 to 2001 in Luristan province, western Iran. These species include the cestode larvae Cysticercus tenuicollis (25%), C. cellulosae (8.3%), the nematodes Metastrongylus apri (41.6%), M. pudendotectus (16.6%), M. salmi (8.3%), Trichuris suis (8.3%) and the acanthocephalan Macracanthorhynchus hirudinaceus (41.6%). No trematodes were found. Seven wild boars (58.3%) were identified as having at least one helminth species. A single infection was detected in 16.6% of cases, but a three species infection covered the highest rank (25%). All these helminths have been reported from other areas of Iran including the north, northeast and southwest, but not in Luristan. Among seven helminths identified, at least three species are transmissible to humans. The public health significance of these helminths is discussed.

  8. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Göttingen Minipigs (Sus scrofa domestica)

    PubMed Central

    Pils, Marina C; Dreckmann, Karla; Jansson, Katharina; Glage, Silke; Held, Nadine; Sommer, Wiebke; Länger, Florian; Avsar, Murat; Warnecke, Gregor; Bleich, André

    2016-01-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) infection was diagnosed in 6 Göttingen minipigs (Sus scrofa domestica) with severe interstitial pneumonia. The virus was defined as a North American (NA) subtype virus, which is common in the commercial pig population and might be derived from a widely used attenuated live-virus vaccine in Europe. The ORF5 sequence of the isolated PRRSV was 98% identical to the vaccine virus. The affected pigs were part of a lung transplantation model and received tacrolimus and steroids as well as irradiation or CD8 antibody for immunosuppression. The likely source of the infection was pigs that were shedding the identified PRRSV, which were housed in a separate room of the same building. This case report provides evidence that a virus closely related to an attenuated live vaccine might cause severe pneumonia and death in PRRSV-seronegative pigs receiving immunosuppressive treatment. We recommend strict barrier housing for immunocompromised pigs. PMID:27780006

  9. Multiplex serology for common viral infections in feral pigs (Sus scrofa) in Hawaii between 2007 and 2010.

    PubMed

    Stephenson, Rachel J; Trible, Benjamin R; Wang, Yu; Kerrigan, Maureen A; Goldstein, Samuel M; Rowland, Raymond R R

    2015-01-01

    Multiplex serology was performed for the detection of total immunoglobulin (Ig) and IgM antibodies against porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and swine influenza virus (SIV) antigens in feral swine (Sus scrofa). Serum samples were collected from the islands of Oahu (292 pigs) and Hawaii (52 pigs) between 2007 and 2010. The highest antibody prevalence was to PCV2 (63%), followed by SIV (7.8%) and PRRSV (5.8%). Antigen-specific IgM was detected at a much lower prevalence. PCR amplification and sequence analysis of PCV2 in three IgM-positive samples identified PCV2b as the only genotype. While the prevalence of PCV2 and PRRSV remained similar between 2007 and 2010, the percentage of SIV-positive samples on Oahu increased from 2% to 19%. Our results demonstrate the utility of multiplex serology for pathogen surveillance in feral pig populations.

  10. Spargana in a Weasel, Mustela sibirica manchurica, and a Wild Boar, Sus scrofa, from Gangwon-do, Korea

    PubMed Central

    Lee, Seung-Ha; Choe, Eun-Yoon; Shin, Hyun-Duk

    2013-01-01

    To know the status of sparganum (plerocercoid of Spirometra erinacei) infection in the Korean wild life, several species of wild animals were captured in Gangwon-do and examined for their status of infection with spargana. From February to December 2011, a total of 62 wild boars, 5 badgers, 1 weasel, 1 Siberian chipmunk, and 53 wild rodents were captured, and their whole muscles were examined with naked eyes for the presence of spargana worms. From the weasel and 1 wild boar, a total of 5 spargana specimens were extracted. The weasel was for the first time recorded as an intermediate or paratenic/transport host of S. erinacei in Korea, and both the weasel (Mustela sibirica manchurica) and wild boar (Sus scrofa) were added to the list of wild animals carrying spargana. PMID:23864753

  11. Volatile emission of decomposing pig carcasses (Sus scrofa domesticus L.) as an indicator for the postmortem interval.

    PubMed

    Paczkowski, Sebastian; Nicke, Sara; Ziegenhagen, Henrik; Schütz, Stefan

    2015-01-01

    This study aimed at correlating selected carcass borne volatile organic compounds (VOCs) with the postmortem interval (PMI). Selected volatiles should 1st be reliably emitted during vertebrate decay, 2nd be emitted at high concentrations, and 3rd show a reproducible quantitative dynamic during the decaying process. Four pigs (Sus scrofa domesticus L.) were placed in a deciduous forest in different seasons and volatiles emitted during the decaying process were sampled. Seventeen compounds were identified and quantified by GC-MS. Electrophysiological experiments on the antenna of female Calliphora vicina and additional data of Dermestes maculans were used as an evolutionary tuned information filter to evaluate the 1st criterion. The relative quantitative emission of hexanal, nonanal, dimethyl disulfide, dimethyl trisulfide, 1-butanol, and phenol were correlated with the PMI, and the observed stages of decay and the limitations of this model were discussed.

  12. Seroprevalence of Trichinella sp. in Wild Boars (Sus scrofa) from Yanggu-gun, Gangwon-do, Korea.

    PubMed

    Lee, Hye-Jung; Chung, Ok-Sik; Kim, Jae-Lip; Lee, Seung-Ha; Yoo, Young-Bok; Seo, Min

    2015-04-01

    A total 7 outbreaks of trichinellosis have occurred in Korea, mostly as a result of consumption of raw wild boar (Sus scrofa) meat. Since only 1 serological survey on wild boars had yet been performed in Korea, the present study aimed to estimate the prevalence of trichinellosis in wild boars and some species of rodents by artificial digestion and serological examinations in Yanggu-gun, Gangwon-do, the endemic area of trichinellosis. Both the wild boar and rodent muscle samples revealed no Trichinella larvae by direct examination and artificial digestion method. However, serological examinations revealed that 4 wild boar sera samples out of 118 (3.4%) were positive to Trichinella antigen. Although the recovery of Trichinella larvae ended in a failure, it is proved for the first time that the sylvatic cycle of Trichinella has been maintained in wild boars of Gangwon-do, Korea.

  13. Multiple Origins and Admixture of Recently Expanding Japanese Wild Boar (Sus scrofa leucomystax) Populations in Toyama Prefecture of Japan.

    PubMed

    Yamazaki, Yuji; Adachi, Fuminari; Sawamura, Akira

    2016-02-01

    Japanese wild boar (Sus scrofa leucomystax) populations have expanded drastically throughout the Japanese Archipelago in recent decades. To elucidate the dispersal patterns of Japanese wild boar in Toyama Prefecture in central Japan, we used a multi-locus microsatellite DNA analysis to determine its population structure and the degree of admixture. The deviation from Hardy-Weinberg equilibrium was detected in either total or separate regional wild boar samples from Toyama Prefecture. This result could be explained by the Wahlund effect resulting from the mixture of samples from different sources. Bayesian structure analysis, assignment test, and factorial correspondence analysis suggested that wild boars around Toyama Prefecture derive from at least two ancestral sources. The migration and possible mating of each individual may have occurred recently and continued in each geographically neighboring region. The present genetic results may be useful for prediction of future dispersal patterns of Japanese wild boar, as well as other animals in expansion.

  14. Emergency removal of a grinding wheel embedded in the midface via modified Le Fort I osteotomy.

    PubMed

    Jiang, W H; Wang, X D; Shen, G F

    2011-04-01

    Le Fort I osteotomy is commonly used to rectify craniofacial deformity in orthognathic surgery and it can be used in approaching a cranial base lesion. This technique has not been well documented in craniofacial penetrating trauma. This article describes a case of midface penetrating injury caused by a grinding wheel. A modified Le Fort I osteotomy was used to remove the foreign object. This surgical approach can be safe and effective when removing foreign bodies in the midface. Good access and adequate exposure can be achieved, which facilitate precise foreign body extraction and achieve reasonable cosmetic results.

  15. Interpretation des donnees de flux de chaleur et de gravite dans le bouclier Canadien

    NASA Astrophysics Data System (ADS)

    Cheng, Li Zhen

    2000-10-01

    Le champ geothermique du Bouclier Canadien est caracterise par un flux moyen de 41 mW·m-2, qui suggere une production de chaleur moyenne dans la croute comprise entre 0.7 et 0.8 muW·m-3. Le flux de chaleur relativement faible favorise la stabilite du bouclier et lui a permis de resister a la deformation tectonique. Les variations du flux de chaleur a la surface sont dominees par la composition de la croute. Un flux eleve implique generalement une composition felsique et il est d'autant plus faible que la croute devient plus mafique. La production de chaleur en surface n'est pas representative de la production moyenne de la croute. Le flux de chaleur dans le Boucher Canadien ne depend donc pas de la production de chaleur en surface, mais depend de la composition principale de la croute. L'interpretation combinee des donnees geophysiques nous permet de determiner les variations de composition d'echelle crustale a partir desquelles il est possible d'etablir la structure de la croute. L'etude detaillee de l'Orogene de Trans-Hudson et de la Sous-province d'Abitibi a montre que le flux de chaleur, la gravite et la sismique lorsqu'elles sont combinees fournissent des contraintes efficaces pour determiner l'architecture crustale. En general, la croute est trop resistante pour se deformer par fluage, excepte tres localement. Le mode de deformation de la lithosphere continentale depend de la composition et du gradient geothermique. Nous montrons que la lithosphere du Bouclier Canadien demeure principalement fragile jusqu'a une profondeur de plus de 150 km. Une deformation ductile pourrait cependant etre possible localement a la base de la, croute, comme dans la ceinture de Thompson par exemple. Si l'on admet que la lithosphere peut resister a des contraintes allant jusqu'a 20 MPa (taux de deformation 3˙ < 10-15 s-1), l'epaisseur de la lithosphere est de l'ordre de 300 km pour la ceinture de Thompson et est superieure a 300 km pour la sous-province d'Abitibi. La resistance

  16. Le glaucome congénitale et la neurofibromatose type 1

    PubMed Central

    Tzili, Nazih; El Orch, Hamza; Bencherifa, Fatiha; Chefchaouni, Mohammed Charif; Abdallah, El Hassan; Berraho, Amina

    2015-01-01

    Le glaucome congénital constitue une complication ophtalmologique dans la neurofibromatose type 1 ou maladie de von Recklinghausen. Nous rapportons un cas de glaucome congénitale dans le cadre d'une neurofibromatose de type 1, à travers lequel on va discuter les mécanismes étiopathogénique, les difficultés thérapeutiques et les facteurs pronostiques du glaucome congénital au cours la maladie de von Recklinghausen avec revue de la littérature. PMID:26405492

  17. Conductivite dans le modele de Hubbard bi-dimensionnel a faible couplage

    NASA Astrophysics Data System (ADS)

    Bergeron, Dominic

    Le modele de Hubbard bi-dimensionnel (2D) est souvent considere comme le modele minimal pour les supraconducteurs a haute temperature critique a base d'oxyde de cuivre (SCHT). Sur un reseau carre, ce modele possede les phases qui sont communes a tous les SCHT, la phase antiferromagnetique, la phase supraconductrice et la phase dite du pseudogap. Il n'a pas de solution exacte, toutefois, plusieurs methodes approximatives permettent d'etudier ses proprietes de facon numerique. Les proprietes optiques et de transport sont bien connues dans les SCHT et sont donc de bonne candidates pour valider un modele theorique et aider a comprendre mieux la physique de ces materiaux. La presente these porte sur le calcul de ces proprietes pour le modele de Hubbard 2D a couplage faible ou intermediaire. La methode de calcul utilisee est l'approche auto-coherente a deux particules (ACDP), qui est non-perturbative et inclue l'effet des fluctuations de spin et de charge a toutes les longueurs d'onde. La derivation complete de l'expression de la conductivite dans l'approche ACDP est presentee. Cette expression contient ce qu'on appelle les corrections de vertex, qui tiennent compte des correlations entre quasi-particules. Pour rendre possible le calcul numerique de ces corrections, des algorithmes utilisant, entre autres, des transformees de Fourier rapides et des splines cubiques sont developpes. Les calculs sont faits pour le reseau carre avec sauts aux plus proches voisins autour du point critique antiferromagnetique. Aux dopages plus faibles que le point critique, la conductivite optique presente une bosse dans l'infrarouge moyen a basse temperature, tel qu'observe dans plusieurs SCHT. Dans la resistivite en fonction de la temperature, on trouve un comportement isolant dans le pseudogap lorsque les corrections de vertex sont negligees et metallique lorsqu'elles sont prises en compte. Pres du point critique, la resistivite est lineaire en T a basse temperature et devient

  18. The genetic impact of demographic decline and reintroduction in the wild boar (Sus scrofa): a microsatellite analysis.

    PubMed

    Vernesi, C; Crestanello, B; Pecchioli, E; Tartari, D; Caramelli, D; Hauffe, H; Bertorelle, G

    2003-03-01

    The reintroduction of wild boar from central Europe after World War II has contributed substantially to the range expansion of this species in Italy, where indiscriminate hunting in earlier times resulted in extreme demographic reduction. However, the genetic impact of such processes is not well-understood. In this study, 105 individuals from Italian and Hungarian wild boar populations were characterized for nine autosomal microsatellite loci. The Hungarian samples, and two central Italian samples from protected areas (parks) where reintroduction is not documented, were assumed to be representative of the genetic composition of the source and the target populations in the reintroduction process, respectively. Animals hunted in the wild in the Florence area of Tuscany (Italy) were then studied to identify the effects of reintroduction. The results we obtained can be summarized as follows: (i) none of the populations analysed shows genetic evidence of demographic decline; (ii) the three parental populations from Italy and Hungary are genetically distinct; however, the low level of divergence appears in conflict with the naming of the Italian and the European subspecies (Sus scrofa majori and Sus scrofa scrofa, respectively); in addition, the Italian groups appear to be as divergent from each other as they are from the Hungarian population; (iii) most of the individuals hunted near Florence are genetically intermediate between the parental groups, suggesting that hybridization has occurred in this area, the average introgression of Hungarian genotypes is 13%, but approximately 45% of the genetic pool of these individuals can not be directly attributed to any of the parental populations we analysed; (iv) analysis of microsatellite loci, though in a limited number, is an important tool for estimating the genetic effect of reintroduction in the wild boar, and therefore for the development of conservation and management strategies for this species.

  19. Experiment and numerical simulation on cross-die forming of SUS304 metastable austenitic stainless using a modified Johnson-Cook model

    NASA Astrophysics Data System (ADS)

    Li, Xifeng; Ding, Wei; Ye, Liyan; Chen, Jun

    2013-12-01

    True stress-strain curves of SUS304 metastable austenitic stainless steel at various strain rates were fitted by a modified Johnson-Cook material model. The effect of blank-holder force on Cross-die forming of SUS304 stainless steel was studied. The forming process was also simulated by the software Marc based on this model. Major strain distribution, thickness distribution and load-displacement were compared between experiment and simulation. The results indicated the modified Johnson-Cook model could well predict the deformation behavior of SUS304 stainless steel. The martensitie volume fraction at different positions of the formed part was in good agreement with what can be expected.

  20. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  1. The Center for Learning Technologies in Urban Schools (LeTUS) Program[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The "LeTUS" program is a three-year, project-based, technology-integrated middle school science curriculum for grades 6-8. The "LeTUS" program is composed of multiple units, each lasting between eight and ten weeks. Topics include global warming, water and air quality, force and motion, communicable diseases, and ecological…

  2. 78 FR 16565 - Culturally Significant Objects Imported for Exhibition Determinations: “Le Corbusier: An Atlas of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Le Corbusier: An Atlas of Modern..., 2003), I hereby determine that the objects to be included in the exhibition ``Le Corbusier: An Atlas...

  3. Pour Une Poesie Chretienne a L'age Baroque: Mysticisme, Heroisme et Feminisme Chez Pierre Le Moyne 1602-1671

    ERIC Educational Resources Information Center

    Fares, Laila

    2012-01-01

    The study constituting the object of this research on one of the best French poets of the 17th century, yet one of the least known, Pierre Le Moyne, aims at restoring this great French poet in his right place, preparing and clearing the way in order to allow further research and stimulate future interest in his works. Pierre Le Moyne is not only…

  4. Retour vers le futur: l'expérience des patients et le lien avec la qualité, la sécurité et le rendement financier.

    PubMed

    Cochrane, Bonnie S; Hagins, Mitch; King, John A; Picciano, Gino; McCafferty, Maureen M; Nelson, Brian

    2015-11-01

    Au Canada, l'amélioration de l'expérience des patients est devenue une priorité des politiques de santé. Le perfectionnement et la normalisation des outils et systèmes pour surveiller les mesures de l'expérience des patients augmentent, tandis que la tendance vers une plus grande reddition de compte sur des améliorations durables et abordables se confirme. Pour de nombreux professionnels de la santé, ce phénomène fait foi d'un intérêt renouvelé pour les besoins et priorités fondamentaux des patients, après des décennies où les changements structurels et technologiques ont dominé les programmes de santé. Pour les leaders en santé canadiens, l'amélioration de l'expérience des patients comporte actuellement de grands défis et de belles possibilités. À cet égard, l'expérience des organisations partenaires du groupe Studer au Canada est à la fois pertinente et instructive. Ces organisations ont adopté un modèle, du nom de Evidence-Based Leadership (EBL, ou leadership fondé sur des données probantes), qui favorise et soutient l'harmonisation de l'ensemble des activités et des comportements, conformément à des objectifs organisationnels précis, y compris des améliorations mesurables de l'expérience des patients. Le présent article expose des études de cas d'organisations qui ont adopté l'EBL. Ces organisations ont réalisé des progrès rapides en matière d'indicateurs de l'expérience des patients, ainsi que dans des secteurs essentiels comme les résultats cliniques, la sécurité et le rendement financier. Les données émergentes sur les facteurs et processus qui sous-tendent ces améliorations sont également abordées.

  5. Spectrofluorimetric determination of dopamine receptor antagonist LE 300 in mice plasma.

    PubMed

    Hefnawy, Mohamed; Mohamed, Mostafa; Abunassif, Mohamed; Alanazi, Amer; Al-Majed, Abdulrahman; Jochen, Lehmann; Mostafa, Gamal Abdel-Hafiz

    2016-02-01

    A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of a novel type of dopamine receptor antagonist LE300 in mouse plasma. The method is based on measuring the native fluorescence of LE-300 in methanol at 343 nm after excitation at 280 nm. The fluorescence concentration plot was rectilinear over the range of 3.5-100 ng/mL with a lower detection limit of 1.0 ng/mL and quantification limit of 3.5 ng/mL. The method was statistically validated for linearity, accuracy, precision and selectivity according to the International Conference on Harmonization guidelines. The accuracy and precision results was expressed as % recovery and relative standard deviation (RSD). The accuracy for LE-300 was in the range 95.5-103.6% and RSD values were in the range of 0.21-1.55% of the theoretical value. The method was successfully applied to the analysis of LE-300 in mice plasma. The results were compared statistically with those obtained by the reported method and were found to be in good agreement, which could be applied in a pharmacokinetic study.

  6. Taking Your Talents to Business Communications: Analyzing Effective Communication through LeBron James's Career Moves

    ERIC Educational Resources Information Center

    Manisaligil, Alperen; Bilimoria, Diana

    2016-01-01

    We describe an in-class activity that helps students improve their skills in media selection and use to reinforce effective communication. The activity builds on media richness and channel expansion theories through an examination of the media selection and use of NBA athlete LeBron James and Cleveland Cavaliers majority owner Dan Gilbert during…

  7. Selected data for stream subbasins in the Le Sueur River basin, south-central Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.; Payne, G.A.

    1990-01-01

    This report presents selected data that describe the characteristics of stream basins upstream from selected points on streams in the Le Sueur River basin. The points on the streams include outlets of subbasins of about five square miles, sewage treatment plant outlets, and U.S. Geological Survey streamflow-gaging stations in the basin.

  8. List processing software for the LeCroy 1821 Segment Manager Interface

    SciTech Connect

    Dorries, T.; Moore, C.; Pordes, R.

    1987-05-01

    Many experiments at Fermilab now include some FASTBUS electronics in their data readout. The software reported in this paper provides general support for the LeCroy 1821 interface. The list processing device drivers allow FASTBUS data to be read out efficiently into the Fermilab Computing Department supported data acquisition systems.

  9. Le syndrome de Stewart-Treves compliquant un lymphœdème chronique idiopathique

    PubMed Central

    Safini, Fatima; Naim, Asmaa; Bouchbika, Zineb; Benchakroun, Nadia; Jouhadi, Hassan; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2014-01-01

    Le syndrome de Stewart-Treves (SST) est une entité rare, correspondant à un angiosarcome cutané compliquant un lymphoedème chronique. Il est de mauvais pronostic. Stewart et Treves ont rapportés en 1948, les premiers cas d'angiosarcome secondaire à un traitement du cancer du sein. Ce terme s'est généralisé pour regrouper l'ensemble des cas de lymphangiosarcome sur lymphoedème d'origine congénital héréditaire ou non héréditaire, post-traumatique ou post-infectieux. Le SST sur un lymphoedème idiopathique reste exceptionnel. Nous rapportons le cas rare d'une patiente présentant un lymphoedème chronique primitif idiopathique des quatre membres évoluant depuis l'adolescence et qui a développé un SST du membre supérieur droit. Elle a subi une amputation à mi- bras vu le caractère très évolué de la tumeur PMID:25883738

  10. "Ambivalence to Technology in Jeunet's" Le Fabuleux Destin d'Amelie Poulain

    ERIC Educational Resources Information Center

    Moore, Rick Clifton

    2006-01-01

    Although at one level Jean-Pierre Jeunets "Le Fabuleux Destin d'Amelie Poulain" is a sweet, attractive film about a young Parisian doing good deeds, it also offers a compelling analysis of the role of technology in our modern lives. The film paints a world where machines and a mechanistic worldview are appealing because humans have a desire to…

  11. LE[superscript 3]AD Academy Builds Professionalism in Vocational Students

    ERIC Educational Resources Information Center

    Hall, Candace

    2012-01-01

    Principal David Wheeler of Southeastern Regional Vocational-Technical High School founded LE[superscript 3]AD Academy--an innovative program that gives students the opportunity to build and run their own town in teams and with guidance from teachers. The program started in the spring of 2011, and it is innovative in many ways. The students' main…

  12. Through Ecofeminist Eyes: Le Guin's "The Ones Who Walk Away from Omelas"

    ERIC Educational Resources Information Center

    Bennett, Barbara

    2005-01-01

    Barbara Bennett explains the tenets behind ecofeminism and why it is a useful and appropriate method of literary analysis for today's world. By applying the theory to Le Guin's story, she helps her students relate the issues of ecofeminism to their American lifestyle.

  13. 9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP OF SMALL FRONT FIREPLACE, SOUTHWEST ROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  14. 11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ROOM SHOWING ORIGINAL CORNER FIREPLACE, OPENING BEHIND BAR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  15. 8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 REEDING DETAIL OF MANTEL IN NORTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  16. 13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 STAIR DETAIL, SECOND FLOOR LEVEL (INSPECTION OF STAIR REVEALS PRESENCE OF A STRING OPPOSITE BANNISTER ORIGINALLY). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  17. 6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHWEST ROOM SHOWING COOK FIREPLACE, ORIGINAL MANTEL, CRANE AND OPENING FOR BAKE OVEN. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  18. 12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP DETAIL OF CORNER FIREPLACE. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  19. 8. VIEW FORWARD IN CREW'S QUARTERS (FOC'S'LE) SHOWING DOUBLE TIER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW FORWARD IN CREW'S QUARTERS (FOC'S'LE) SHOWING DOUBLE TIER OF BUNKS IN THE EVELINA M. GOULART. KINGPOST IS AT CENTER OF PHOTOGRAPH WITH FORE PEAK IN BACKGROUND. A FOLDING MESS TABLE IS AT LOWER LEFT OF PHOTOGRAPH. NOTE BENCH SEAT BELOW LOWEST TIER OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  20. 10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE EVELINA M. GOULART. OBJECT IN THE FOREGROUND IS A FOLDING MESS TABLE LOCATED BETWEEN THE TIERS OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  1. Habitat and nesting of Le Conte's Sparrows in the northern tallgrass prairie

    USGS Publications Warehouse

    Winter, M.; Shaffer, J.A.; Johnson, D.H.; Donovan, T.M.; Svedarsky, W.D.; Jones, P.W.; Euliss, B.R.

    2005-01-01

    Little is known about the breeding biology of the Le Conte's Sparrow (Ammodramus leconteii), probably because of its secretive nature. We provide new information on several aspects of Le Conte's Sparrow breeding biology, including rates of nest parasitism by Brown-headed Cowbirds (Molothrus ater) and potential factors affecting breeding densities and nesting success of the species. Our study was conducted in the tallgrass prairie of northwestern Minnesota and southeastern North Dakota during 1998-2002. Breeding densities varied among years, but this variation was not clearly linked to climatic patterns. Vegetation had some influence on densities of Le Conte's Sparrows; densities were highest in grasslands with moderate amounts of bare ground. Prairie patch size and the percentage of shrubs and trees in the landscape had no recognizable influence on density. Nesting success was highly variable among sites and years and increased slightly with distance from trees. Rates of nest parasitism were low (1 of 50 nests parasitized), and clutch sizes were similar to those of other studies of Le Conte's Sparrows.

  2. 5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, NORTHEAST AND SOUTHEAST PARLORS, ORIGINAL MANTEL (LEFT - RADIATOR COVERED). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  3. From Interactive Open Learner Modelling to Intelligent Mentoring: STyLE-OLM and Beyond

    ERIC Educational Resources Information Center

    Dimitrova, Vania; Brna, Paul

    2016-01-01

    STyLE-OLM (Dimitrova 2003 "International Journal of Artificial Intelligence in Education," 13, 35-78) presented a framework for interactive open learner modelling which entails the development of the means by which learners can "inspect," "discuss" and "alter" the learner model that has been jointly…

  4. Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening.

    PubMed

    Chen, Weiwei; Kong, Junhua; Lai, Tongfei; Manning, Kenneth; Wu, Chaoqun; Wang, Ying; Qin, Cheng; Li, Bin; Yu, Zhiming; Zhang, Xian; He, Meiling; Zhang, Pengcheng; Gu, Mei; Yang, Xin; Mahammed, Atef; Li, Chunyang; Osman, Toba; Shi, Nongnong; Wang, Huizhong; Jackson, Stephen; Liu, Yule; Gallusci, Philippe; Hong, Yiguo

    2015-01-19

    In plants, microRNAs (miRNAs) play essential roles in growth, development, yield, stress response and interactions with pathogens. However no miRNA has been experimentally documented to be functionally involved in fruit ripening although many miRNAs have been profiled in fruits. Here we show that SlymiR157 and SlymiR156 differentially modulate ripening and softening in tomato (Solanum lycopersicum). SlymiR157 is expressed and developmentally regulated in normal tomato fruits and in those of the Colourless non-ripening (Cnr) epimutant. It regulates expression of the key ripening gene LeSPL-CNR in a likely dose-dependent manner through miRNA-induced mRNA degradation and translation repression. Viral delivery of either pre-SlymiR157 or mature SlymiR157 results in delayed ripening. Furthermore, qRT-PCR profiling of key ripening regulatory genes indicates that the SlymiR157-target LeSPL-CNR may affect expression of LeMADS-RIN, LeHB1, SlAP2a and SlTAGL1. However SlymiR156 does not affect the onset of ripening, but it impacts fruit softening after the red ripe stage. Our findings reveal that working together with a ripening network of transcription factors, SlymiR157 and SlymiR156 form a critical additional layer of regulatory control over the fruit ripening process in tomato.

  5. Coût clinique des retards dans le changement de traitement

    PubMed Central

    Walmsley, Sharon

    2007-01-01

    La prise en charge des patients séropositifs pour le VIH ayant déjà reçu un traitement continue de s’améliorer et d’évoluer. Les nouvelles lignes directrices semblent indiquer que l’objectif du traitement devrait être une suppression virologique maximale. La meilleure façon d’y parvenir consiste à utiliser une combinaison d’agents auxquels le virus sera le plus vraisemblablement sensible et, si possible, des agents appartenant à une nouvelle classe thérapeutique. Les cas discutés démontrent comment l’utilisation d’un schéma thérapeutique puissant à titre de traitement de sauvetage peut avoir de bons résultats virologiques, immunologiques et cliniques. Toutefois, si le traitement de sauvetage retenu n’est pas assez puissant pour atteindre ces objectifs, la durabilité de la réponse est limitée. Ce qu’il faut retenir ici, c’est que ces stratégies devraient reposer sur la puissance du schéma thérapeutique et qu’il ne faut pas retarder l’instauration des agents en cas d’échec d’une stratégie.

  6. Le monde des affaires (The Business World). Teacher's Guide [and] Student's Book.

    ERIC Educational Resources Information Center

    Laing, Martha; Ullmann, Rebecca

    The two components of this publication are the student's book and the teacher's guide to the module, "The Business World" or "Le monde des affaires," which would be suitable for use in an advanced French course or in a class of business French. The teacher's book in French and English has four parts: (1) an explanation of the…

  7. Tested Demonstrations: Thermodynamic Changes, Kinetics, Equilibrium, and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for demonstrating thermodynamic changes, kinetics and reaction mechanisms, equilibrium, and LeChatelier's principle are presented. The only materials needed for these demonstrations are beakers, water, assorted wooden blocks of varying thickness, assorted rubber tubing, and a sponge. The concepts illustrated in each demonstration are…

  8. Geomorphic evolution of the Le Sueur River, Minnesota, USA, and implications for current sediment loading

    USGS Publications Warehouse

    Gran, K.B.; Belmont, P.; Day, S.S.; Jennings, C.; Johnson, Aaron H.; Perg, L.; Wilcock, P.R.

    2009-01-01

    There is clear evidence that the Minnesota River is the major sediment source for Lake Pepin and that the Le Sueur River is a major source to the Minnesota River. Turbidity levels are high enough to require management actions. We take advantage of the well-constrained Holocene history of the Le Sueur basin and use a combination of remote sensing, fi eld, and stream gauge observations to constrain the contributions of different sediment sources to the Le Sueur River. Understanding the type, location, and magnitude of sediment sources is essential for unraveling the Holocene development of the basin as well as for guiding management decisions about investments to reduce sediment loads. Rapid base-level fall at the outlet of the Le Sueur River 11,500 yr B.P. triggered up to 70 m of channel incision at the mouth. Slope-area analyses of river longitudinal profi les show that knickpoints have migrated 30-35 km upstream on all three major branches of the river, eroding 1.2-2.6 ?? 109 Mg of sediment from the lower valleys in the process. The knick zones separate the basin into an upper watershed, receiving sediment primarily from uplands and streambanks, and a lower, incised zone, which receives additional sediment from high bluffs and ravines. Stream gauges installed above and below knick zones show dramatic increases in sediment loading above that expected from increases in drainage area, indicating substantial inputs from bluffs and ravines.

  9. Le chondrosarcome naso-sinusien: à propos de deux cas et revue de la literature

    PubMed Central

    Touati, Mohamed Mliha; Chihani, Mehdi; Darouassi, Youssef; Lakouichmi, Mohammed; Tourabi, Khalid; Bouaity, Brahim; Ammar, Haddou

    2014-01-01

    Le chondrosarcome est une tumeur maligne très destructrice d'origine cartilagineuse, osseuse et mesnchymateuse. La localisation au niveau de la tête et cou est rare et le siège naso sinusien est encore plus rare. Nous rapportons deux observations de chondrosarcome du sinus maxillaire droit et sphéno ethmoïdale. Le but de notre travail est de montrer à travers ces deux cas cliniques, l'intérêt de la tomodensitométrie et de la résonance magnétique dans la présemption diagnostique en corrélation avec la clinique et l'endoscopie,de discuter le choix de la voix et la technique d'abord chirurgical et la surveillance post opératoire. A travers ces deux observations nous soulignerons les difficultés que pose cette tumeur à l'anatomopathologiste pour différencier entre chondrome et chondrosarcome. PMID:25810801

  10. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  11. Students' and Teachers' Misapplication of Le Chatelier's Principle: Implications for the Teaching of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Quilez-Pardo, Juan; Solaz-Portoles, Joan Josep

    1995-01-01

    Study of strategies and procedures of 170 students and 40 teachers when solving chemical equilibrium problems found misconceptions emerging through: misapplication of Le Chatelier's Principle, use of rote-learning recall, incorrect control of variables, limited use of chemical equilibrium law, lack of mastery of chemical equilibrium principles,…

  12. The Adverse Effects of Le Chatelier's Principle on Teacher Understanding of Chemical Equilibrium

    ERIC Educational Resources Information Center

    Cheung, Derek

    2009-01-01

    Although the scientific inadequacy of Le Chatelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has…

  13. Macrosphelide B suppressed metastasis through inhibition of adhesion of sLe(x)/E-selectin molecules.

    PubMed

    Fukami, Akiko; Iijima, Kousuke; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi

    2002-03-08

    Macrosphelide B (MSB), a 16-membered macrolide from Microsphaeropsis sp. FO-5050, inhibits adhesion of sialyl Lewis(x) (sLe(x))-expressing HL-60 cells to LPS-activated (E-selectin-expressing) human umbilical vein endothelial cells (HUVECs) in vitro. This study examines MSB effects on metastasis of B16/BL6 mouse melanoma cells (B16/BL6 cells) and L5178Y-ML mouse lymphoma cells in vivo and analyzes the MSB antimetastatic activity mechanism. When administered MSB at 20 mg/kg/day, lung metastatic nodules of B16/BL6 cells were significantly decreased (T/C = 45%). However, no inhibition of metastasis of L5178Y-ML cells to the spleen and liver was observed. Flow cytometry analysis showed that B16/BL6 cells expressed high levels of sLe(x) antigen, whereas expression on L5178Y-ML cells was low. Under in vitro conditions, B16/BL6 cells demonstrated a greater degree of adhesion to LPS-activated HUVECs than L5178Y-ML cells, but adhesion was significantly inhibited by MSB and sLe(x) antibody. Combined therapy of MSB and cisplatin (CDDP) induced remarkable lung metastasis inhibition without adverse effects of CDDP to the host. All these findings suggest that MSB suppresses lung metastasis of B16/BL6 cells by inhibiting cell adhesion to endothelial cells through the sLe(x) molecule.

  14. The Ammonia Synthesis Reaction: An Exception to the Le Chatelier Principle and Effects of Nonideality

    ERIC Educational Resources Information Center

    Uline, Mark J.; Corti, David S.

    2006-01-01

    Le Chatelier's principle states that the further addition of a particular component will cause the reaction to shift in the direction that reduces the total number of moles of the system. However, the addition of one reactant [N[subscript 2

  15. Le Chatelier's Principle: The Effect of Temperature on the Solubility of Solids in Liquids.

    ERIC Educational Resources Information Center

    Brice, L. K.

    1983-01-01

    Provides a rigorous but straightforward thermodynamic treatment of the temperature dependence of the solubility of solids in liquids that is suitable for presentation to undergraduates, suggesting how to approach the qualitative aspects of the subject for freshmen. Considers unsolvated/solvated solutes and Le Chatelier's principle. (JN)

  16. The Potassium-Argon Laser Experiment (KarLE): In Situ Geochronology for Mars and Beyond

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2014-01-01

    The search for life in the solar system depends upon discovering the right moments in planetary evolution: when habitable environments existed, when they declined, and when geologic processes operated to preserve traces of life after death. However, an incomplete knowledge of absolute Martian geochronology limits our ability to understand the timing of Martian evolutionary milestones, major climate changes, and stratigraphic epochs [1, 2]. Absolute dating relates these habitability markers to planetarywide geologic, atmospheric, and climate history places, and ties their occurrence to the history of the solar system, especially the Earth-Moon system and the timescale of evolution of life on Earth. KArLE is being developed to anchor the relative timeline of geological events to an absolute chronology that puts Mars into a wider solar system context. KArLE makes its measurements on rock samples that can be obtained by landers or rovers and inserted into a small, mechanically simple chamber. KArLE interrogates the samples using laser-induced breakdown spectrocopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of mission payloads to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  17. Developement of the Potassium-Argon Laser Experiment (KArLE) for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Thus far, radiometric geochronology of planetary samples has only been accomplishable in terrestrial laboratories on samples from dedicated sample return missions and meteorites. In situ instruments to measure rock ages have been proposed, but none have yet reached TRL 6, because isotopic measurements with sufficient resolution are challenging. We have begun work under the NASA Planetary Instrument Definition and Development Program (PIDDP) to develop the Potassium (K) - Argon Laser Experiment (KArLE), a novel combination of several flight-proven components that will enable accurate KAr isochron dating of planetary rocks. KArLE will ablate a rock sample, measure the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by measuring the volume of the abated pit using a optical methods such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to 100 Myr, sufficient to address a wide range of geochronology problems in planetary science. Additional benefits derive from the fact that each KArLE component achieves analyses common to most planetary surface missions.

  18. Developing Communication Skills in Deaf Primary School Pupils: Introducing and Evaluating the SmiLE Approach

    ERIC Educational Resources Information Center

    Alton, Sherryn; Herman, Rosalind; Pring, Tim

    2011-01-01

    Many profoundly deaf signers have difficulty communicating with hearing people. This article describes a therapy called "Strategies and Measurable Interaction in Live English" (smiLE; Schamroth and Threadgill, 2007a), an approach used to teach deaf children skills to become successful communicators in real-life situations. This study…

  19. Molecular and cellular characterization of the tomato pollen profilin, LePro1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton in all eukaryotic cells. We previously cloned a profilin gene, designated as LePro1 from tomato pollen. To investigate its biological role, in the present study, We investigated the tem...

  20. [Roentgendiagnostic of the peritoneovenous drainage after Le Veen for ascitestreatment (author's transl)].

    PubMed

    Vogel, H; Dahm, K

    1978-12-01

    The peritoneovenous drainage after Le Veen offers a possibility of the ascitestreatment. The roentgenexamination showed wrong positions of the katheter as the most frequent cause of dysfunctions. They were regularly combined with venous obstructions. The intraoperativ x-ray diagnostic can fascilate the shunt application and may help to spare a second operation.

  1. Borel-Le Roy summability of the high temperature expansion for classical continuous systems

    NASA Astrophysics Data System (ADS)

    Maioli, Marco

    1985-06-01

    For classical gases with suitable pair interactions such that Φ( r)˜(ln r -1) p as r→0 ( p∈ℕ), the Taylor expansion in β of the correlation functions and the pressure are summable at β=0 by the Borel-Le Roy method of order p+1.

  2. Immobilized Lotus tetragonolobus agglutinin binds oligosaccharides containing the Le(x) determinant.

    PubMed

    Yan, L; Wilkins, P P; Alvarez-Manilla, G; Do, S I; Smith, D F; Cummings, R D

    1997-01-01

    A defined set of oligosaccharides and glycopeptides containing alpha-linked fucose were used to examine the specificity of the immobilized fucose-binding lectin Lotus tetragonolobus agglutinin (LTA1), also known as lotus lectin. Glycans containing the Lewis x determinant (Le(x)) Gal beta 1-4[Fuc alpha 1-3]GlcNAc beta 1-3-R were significantly retarded in elution from high density LTA-Emphaze columns. The lectin also bound the fucosylated lacdiNAc trisaccharide GalNAc beta 1-4[Fuc alpha 1-3]GlcNAc. The lectin did not bind glycans containing either sialylLe(x) or VIM-2 determinants, nor did it bind the isomeric Le(x), Gal beta 1-3[Fuc alpha 1-4]GlcNAc-R. Although 2'-fucosyllactose Fuc alpha 1-2Gal beta 1-4Glc) was retarded in elution from the columns, larger glycans containing the H-antigen Fuc alpha 1-2Gal beta 1-3(4)GlcNAc-R interacted poorly with immobilized LTA. Our results demonstrate that immobilized LTA is effective in isolating glycans containing the Le(x) antigen and is useful in analyzing specific fucosylation of glycoconjugates.

  3. Standardissimo. Les limitations théoriques du Modèle Standard. Quelles réponses y apporter?

    NASA Astrophysics Data System (ADS)

    Renard, F. M.

    Nous présentons I 'état du Modèle Standard des interactions fortes, faibles et électromagnétiques. Après une description rapide de ses 3 secteurs, secteur de jauge (radiation), secteur fermionique (matière) et secteur scalaire (génération des masses), nous insistons sur le grand nombre de paramètres libres et sur les choix arbitraires qu'il a fallu faire dans l'élaboration du modèle. Nous faisons ressortir les problèmes techniques non résolus et nous dressons la liste des questions fondamentales restées sans réponses. Nous passons ensuite en revue les idées et méthodes proposées pour répondre à ces questions. Elles utilisent essentiellement 3 voies différentes. La première consiste à requérir plus de symétrie (extension du modèle, symétrie Gauche-Droite, Grandes Unifications, Supersymétrie,...). La seconde contient les diverses alternatives au Modèle Standard impliquant des modifications dans certains secteurs (par exemple le secteur scalaire avec le modèle de la Technicouleur) ou de façon plus violente l'hypothèse d'une sous-structure des leptons, des quarks et des bosons W et Z eux-mêmes. Une dernière voie cherche à justifier les particularités du Modèle Standard et relier ses paramètres libres en se basant sur des principes de cohérence interne du modèle. Les conséquences observables de ces diverses approches sont dans chaque cas mentionnées.

  4. Le cavernome porte chez l'enfant: a propos de 11 cas

    PubMed Central

    Ilham, Tadmori; Mounia, Lakhdar Idrissi; Moustapha, Hida

    2014-01-01

    Le cavernome portal est la conséquence d'une occlusion chronique, du système porte extra-hépatique formé d'un réseau de veines dont le calibre est augmenté et au sein desquelles chemine un sang portal hépatopéte. Chez l'enfant, est une cause majeure d'hypertension portale dite «pré ou infra-hépatique» ou encore «extra-hépatique». Onze cas de cavernome porte parmi 78 cas d'hypertension portale ont été colligés au service sur une période allant du Janvier 2003 au Septembre 2012. L’âge de nos patients variait entre 2 et 15 ans et le sexe ratio est de 1,75. Tous nos patients étaient admis au stade d'hypertension portale avec la splénomégalie SMG (100% des cas); hémorragies digestives (63%); ascite (36%); la circulation veineuse collatérale CVC et l'hépatomégalie HMG (27%). L'exploration endoscopique a objectivé la présence de varices ‘sophagiennes dans tous les cas avec une gastropathie hypertensive dans 27% et des varices ectopiques chez 36%. Les perturbations biologiques étaient dominées par la pancytopénie. Le bilan de thrombophilie était demandé pour tous les malades mais réalisé mais n'est réalisé que chez trois revenus normaux chez deux et a objectivé une baisse de protéine S chez le troisième. L’échographie abdominale était le moyen de diagnostic positif et l’écho-doppler a confirmé l'HTP chez tous nos patients. Aucun de nos malades n'a pu être opéré pour le moment. La ligature a été réalisée chez 54,5%. Dix patients ont nécessité une transfusion sanguine. L’évolution globale de nos patients est favorable. La durée moyenne d’évolution du cavernome porte chez nos patients est de quatre ans. PMID:25870732

  5. Suivi après le traitement du cancer du sein

    PubMed Central

    Sisler, Jeffrey; Chaput, Geneviève; Sussman, Jonathan; Ozokwelu, Emmanuel

    2016-01-01

    Résumé Objectif Offrir aux médecins de famille un résumé des recommandations fondées sur les données probantes pour guider les soins aux survivantes traitées pour le cancer du sein. Qualité des données Une recherche documentaire a été effectuée dans MEDLINE entre 2000 et 2016 à l’aide des mots-clés anglais suivants : breast cancer, survivorship, follow-up care, aftercare, guidelines et survivorship care plans, en se concentrant sur la revue des lignes directrices publiées récemment par les organismes nationaux de cancérologie. Les données étaient de niveaux I à III. Message principal Les soins aux survivantes comportent 4 facettes : surveillance et dépistage, prise en charge des effets à long terme, promotion de la santé et coordination des soins. La surveillance des récidives ne se traduit que par une mammographie annuelle, et le dépistage d’autres cancers doit suivre les lignes directrices basées sur la population. La prise en charge des effets à long terme du cancer et de son traitement aborde des problèmes courants tels la douleur, la fatigue, le lymphœdème, la détresse et les effets indésirables des médicaments, de même que les préoccupations à long terme comme la santé du cœur et des os. La promotion de la santé met en relief les bienfaits de l’activité chez les survivantes du cancer, avec l’accent mis sur l’activité physique. Les soins aux survivantes sont de meilleure qualité lorsque divers services et professionnels de la santé participent aux soins, et le médecin de famille joue un rôle important dans la coordination des soins. Conclusion Les médecins de famille sont de plus en plus souvent les principaux fournisseurs de soins de suivi après le traitement du cancer du sein. Le cancer du sein doit être considéré comme une affection médicale chronique, même chez les femmes en rémission, et les patientes profitent de la même approche que celle utilisée pour les autres affections chroniques en

  6. Le syndrome de cushing chez l'adolescent: à propos de 18 patients

    PubMed Central

    Haraj, Nassim Essabah; El Aziz, Siham; Chadli, Asma

    2015-01-01

    Le syndrome de Cushing est une pathologie rare mais grave chez l'enfant et l'adolescent. Elle diffère de la pathologie adulte par le mode de présentation et la prise en charge. Il s'agit d'une étude rétrospective des dossiers de patients suivis pour syndrome de Cushing au service d'endocrinologie de Casablanca entre 2002 - 2015, incluant les patients âgés au moment du diagnostic de moins de 22 ans, et ayant un suivi d'au moins 1 an. Au total 18 dossiers ont été inclus. L’âge moyen est de 19,55 ans, avec une prédominance féminine. La durée d’évolution moyenne est de 4,05 ans. Le tableau clinique est fait souvent d'une cassure de poids, une obésité ou une séborrhée et acné. La démarche diagnostique est comparable à celle de l'adulte. Sur le plan étiologique on retrouve une prédominance de la maladie de Cushing (15 patients). Sur le plan thérapeutique, 14 patients ont bénéficié d'une chirurgie hypophysaire, avec complément par radiothérapie chez 3 patients devant l’échec de la chirurgie, Une ablation d'une tumeur surrénalienne chez une patiente et une surrénalectomie bilatérale chez trois patients. L’évolution a été marquée par une guérison chez 9 patients et le décès chez 4 (suite à un syndrome de Nelson, infection sévère, choc hémorragique, corticosurrénalome). Les résultats de cette étude soulignent la gravité de cette maladie, ce qui nécessite d'organiser le suivi, en élaborant des programmes spécifiques de suivi médical et de prise en charge psychologique. PMID:26985265

  7. A Comparison of Proximal Tibia and Proximal Humerus Infusion Rates of Plasma Under High Pressure Using the EZ IO Intraosseous Device in the Adult Swine (Sus scrofa) Hypovolemic Model

    DTIC Science & Technology

    2013-01-10

    plasma under high pressure using the EZ IO intraosseous device in the adult swine (Sus scrofa ) hypovolemic model. FWH20100171A FWH20100171ALairet...resuscitation, swine, sus scrofa U U U SAR Vikhyat Bebarta, MD 210-275-3794 WHASC- Animal Final Report 170ct2012 1. Protocol Number: FWH20100171A 2...the EZ 10 intraosseous device in the adult swine (Sus scrofa ) hypovolemic model. 4. Principal Investigator PI): Name Rank Date of Branch Staff

  8. Trends in hailstorm frequency in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; García, C.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The Community of Castile-León is located in the NW of the Iberian Peninsula. One of the most frequent meteorological risks in the Community during the summer is hailstorms. On average, in the Province of León, there are 42 days with storms, almost half of them being hailstorms. However, the spatial variability of the storms is very elevated. The majority of these episodes are registered in mountainous areas during the summer months and they have a convective origin. In the present study, making use of the data from the AEMET's meteorological stations situated in Castile and León, we analyzed trends in the frequency of the appearance of this type of storm from the year 1940 until the present. One of the principal problems we found is that the quality of databases generated from the years without hail precipitation data available are frequent. This is due, in large part, to the difficulty in detecting this type of meteor in meteorological stations, given their large spatial variability and their ephemeral character. On the other hand, with the objective of performing a meteorological analysis of the results found, we have also studied the trends in days with rain and the absolute maximum temperature. The overall analysis of results found allowed us to affirm a large variability in the different regions related to climatic hail series and trends found in those regions. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: CEN20091028; GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22 ).

  9. Prévention de la maladie thromboembolique veineuse chez le brûlé

    PubMed Central

    Siah, S.; El Farouki, A.

    2014-01-01

    Summary Les complications thromboemboliques sont considérées comme rares chez le patient brûlé. Leur incidence varie selon les études réalisées. Les patients brûlés présentent de nombreux facteurs de risque favorisant la survenue de ces complications. Le diagnostic clinique de la thrombose veineuse profonde et de l’embolie pulmonaire reste difficile vu leur évolution infraclinique et la non spécificité des signes cliniques. L’échodoppler veineux et l’angioscanner thoracique constituent les éléments clés dans la stratégie diagnostique de la thrombose veineuse profonde et de l’embolie pulmonaire chez les patients brûlés. Le traitement ne diffère pas de celui administré aux autres patients non brûlés et victimes de la thrombose veineuse profonde et de l’embolie pulmonaire. La prophylaxie controversée entre les auteurs, est un sujet d’actualité. Plusieurs praticiens et organismes recommandent son utilisation de routine chez les patients brûlés à risque. Elle reste le seul moyen capable d’empêcher la survenue de la maladie thromboembolique veineuse capable d’engager le pronostic vital chez ces patients. Nous rapportons 6 observations de patients brûlés ayant développé une maladie thromboembolique veineuse. PMID:26170780

  10. Moderation of skeletal muscle reperfusion injury by a sLe(x)-glycosylated complement inhibitory protein.

    PubMed

    Kyriakides, C; Wang, Y; Austen, W G; Favuzza, J; Kobzik, L; Moore, F D; Hechtman, H B

    2001-07-01

    The role of the sialyl Lewis(x) (sLe(x))-decorated version of soluble complement receptor type 1 (sCR1) in moderating skeletal muscle reperfusion injury, by antagonizing neutrophil endothelial selectin interaction and complement activation, is examined. Mice underwent 2 h of hindlimb ischemia and 3 h of reperfusion. Permeability index (PI) was assessed by extravasation of 125I-labeled albumin. Neutrophil depletion and complement inhibition with sCR1 reduced permeability by 72% (PI 0.81 +/- 0.10) compared with a 42% decrease (PI 1.53 +/- 0.08) observed in neutropenic mice, indicating that part of the complement-mediated injury is neutrophil independent. sCR1sLe(x) treatment reduced PI by 70% (PI 0.86 +/- 0.06), an additional 20% decrease compared with sCR1 treatment (PI 1.32 +/- 0.08). Treatment with sCR1sLe(x) 0.5 and 1 h after reperfusion reduced permeability by 63% (PI 0.09 +/- 0.07) and 52% (PI 1.24 +/- 0.09), respectively, compared with the respective decreases of 41% (PI 1.41 +/- 0.10) and 32% (PI 1.61 +/- 0.07) after sCR1 treatment. Muscle immunohistochemistry stained for sCR1 only on the vascular endothelium of sCR1sLe(x)-treated mice. In conclusion, sCR1sLe(x) is more effective than sCR1 in moderating skeletal muscle reperfusion injury.

  11. Immunochemical and immunohistological expression of Lewis histo-blood group antigens in small intestine including individuals of the Le(a+b+) and Le(a-b-) nonsecretor phenotypes.

    PubMed

    Henry, S M; Samuelsson, B E; Oriol, R

    1994-12-01

    Histological samples and total non-acid glycosphingolipids were prepared from small intestine of human cadavers with the Le(a+b+) and Le(a-b-) nonsecretor phenotypes and contrasted with the more common Lewis phenotypes. Glycolipid fractions were analysed by thin-layer chromatography and tested for Lewis activity with monoclonal antibodies reactive to Lewis epitopes. Paraffin-embedded small intestine sections were also fluorescently immunostained with anti-Lewis antibodies. Unlike the common Lewis positive phenotypes, we were immunochemically able to demonstrate the copresence of large amounts of Lea and Leb glycolipids in the Le(a+b+) sample. In addition we demonstrated increased formation of extended Lewis structures in this phenotype. By immunohistochemistry Lea, Leb and type 1 precursor chain epitopes could be demonstrated in the brush border. These results show that the expression of the Le(a+b+) phenotype at the erythrocyte phenotyping level parallels the small intestinal expression of this phenotype, and the patterns of Lewis antigen expressions are unique to this phenotype. By immunohistochemistry and immunochemistry we also demonstrated the presence of trace amounts of Lewis active glycoconjugates in the small intestine of the Le(a-b-) nonsecretor and Le(a+b-) samples. In the Le(a-b-) nonsecretor Lea and Leb activity was absent and type 1 precursor was present in brush border, while Leb activity was immunohistologically demonstrated in the Golgi apparatus of the deep glands. Trace amounts of both Lea and Leb glycolipids were identified in this sample. In parallel trace Leb activity could also be detected in the glycolipids of the Le(a+b-) sample and could be immunohistologically demonstrated to be fully expressed in occasional cells in the deep glands of the small intestine, a pattern quite dissimilar to that of the Le(a-b-) nonsecretor.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination.

    PubMed

    Brewer-Jensen, Paul; Wilson, Carrie B; Abernethy, John; Mollison, Lonna; Card, Samantha; Searles, Lillie L

    2016-01-01

    Although RNA polymerase II (Pol II) productively transcribes very long genes in vivo, transcription through extragenic sequences often terminates in the promoter-proximal region and the nascent RNA is degraded. Mechanisms that induce early termination and RNA degradation are not well understood in multicellular organisms. Here, we present evidence that the suppressor of sable [su(s)] regulatory pathway of Drosophila melanogaster plays a role in this process. We previously showed that Su(s) promotes exosome-mediated degradation of transcripts from endogenous repeated elements at an Hsp70 locus (Hsp70-αβ elements). In this report, we identify Wdr82 as a component of this process and show that it works with Su(s) to inhibit Pol II elongation through Hsp70-αβ elements. Furthermore, we show that the unstable transcripts produced during this process are polyadenylated at heterogeneous sites that lack canonical polyadenylation signals. We define two distinct regions that mediate this regulation. These results indicate that the Su(s) pathway promotes RNA degradation and transcription termination through a novel mechanism.

  13. An Attempt to Identify Comparatively Supportive and Non-Supportive Environments for Underrepresented Minorities and Females in SUS Colleges of Engineering

    ERIC Educational Resources Information Center

    Micceri, Theodore

    2005-01-01

    This study sought to determine whether consistent differences in enrollment and graduation among different racial/ethnic and sex groups occur at different colleges of Engineering in the Florida State University System (SUS). Analyses were limited to the major institutions (UF, FSU, USF, UCF, FAU, FIU) with the addition of FAMU due to a high…

  14. Investigating Characteristics that Typify Engineering, Computer and Biological Sciences Graduates, the Differences that Occur among and between these Disciplines and the General Population of SUS Graduates

    ERIC Educational Resources Information Center

    Micceri, Theodore

    2005-01-01

    The purpose of this exercise was to determine whether any of the available demographic or academic variables show distinct trends in three specific discipline areas that differ from those of other areas: (1) Engineering, (2) Computer Sciences, and (3) Biological Sciences. Using data from 39,087 SUS graduates in 2002-03 and of 324,164 science…

  15. Blowing Hot and Cold: Protecting Against Climatic Extremes (Souffler le chaud et le froid: comment se proteger contre les conditions climstiques extremes)

    DTIC Science & Technology

    2002-04-01

    biological hazards was clearly identified as an important spin-off of military research as presented at the meeting. For the military aspects of this...de la conférence a été l’intérêt marqué des intervenants pour la recherche en matière de lutte contre le terrorisme. L’optimisation de la...Though terrorism in itself isn’t new, given the scale of the attacks and given the biological attacks afterwards one can state that a new threat has

  16. Developpement d'un compresseur d'hydrogene base sur le cyclage thermique des hydrures metalliques

    NASA Astrophysics Data System (ADS)

    Laurencelle, Francois

    La compression de l'hydrogene est une etape incontournable de son utilisation dans l'industrie actuelle et dans les nouvelles applications energetiques de l'hydrogene (stockage stationnaire et transport). Les compresseurs mecaniques traditionnellement utilises posent plusieurs problemes d'ingenierie, de securite et de maintenance qui pourraient etre contournes en developpant de nouvelles technologies mieux adaptees a l'hydrogene. Dans cette these, notre objectif est de developper d'un compresseur d'hydrogene base sur les hydrures metalliques pouvant etre connecte a la sortie d'un electrolyseur fonctionnant a basse pression et d'ainsi repondre au besoin de productioncompression d'hydrogene decentralisee. La methodologie du projet comprend plusieurs etapes. Premierement, nous faisons la revue bibliographique des projets impliquant des compresseurs a hydrures metalliques. Deuxiemement, a travers des travaux experimentaux, nous recherchons des hydrures permettant une compression efficace entre 20 et 80°C. Les materiaux sont synthetises par fusion a arc electrique et caracterises sur bancs d'essais d'hydrogenation. La structure de certains materiaux est aussi investiguee par rayons X, methode de B.E.T. et microscopie electronique. Troisiemement, un reacteur d'hydrures est concu de maniere a promouvoir des echanges de chaleur rapides et efficaces. Quatriemement, le prototype et son interface de controle sont construits. Cinquiemement, le compresseur est caracterise pour en evaluer les performances en termes de debit et de capacite. Les resultats obtenus sont presentes dans trois articles publies et dans le chapitre 5 de cette these. Le compresseur (article I) est base sur trois hydrures (LaNi 4.8Sn0.2, LaNi5 et MMNi4.7Al0.3 ). Celui-ci permet d'atteindre un debit de compression de 10 a 20 L d'hydrogene par heure et son efficacite est, estimee a ˜5% par rapport a un compresseur adiabatique ideal. Il a ete demontre que l'efficacite pourrait etre augmentee en utilisant un

  17. La chirurgie coronaire sous circulation extra-corporelle chez le patient diabétique

    PubMed Central

    Moutakiallah, Younes; Benzaghmout, Khadija; Aithoussa, Mahdi; Atmani, Nourreddine; Amahzoune, Brahim; Hatim, Abdedaim; Drissi, Mohamed; Benyass, Aatif; ElBekkali, Youssef; Boulahya, Abdelatif

    2014-01-01

    Nous rapportons les résultats de la chirurgie coronaire chez une population de coronariens diabétiques opérés sous circulation extra-corporelle dans le service de chirurgie cardiaque de l'hôpital militaire d'instruction Mohammed V de Rabat. C'est une étude rétrospective menée entre Janvier 2008 et Février 2012 (4 ans), portant sur 103 patients diabétiques consécutifs opérés pour pontage coronaire. L’âge moyen des patients était de 61±8,7ans (37-82ans) avec un sexe ratio (H/F) de 3,9. Tous les patients diabétiques de type 2 et sous traitement anti-diabétique ont été inclus dans cette étude. La sténose du tronc commun gauche était présente chez 26,2% des patients et 53,4% étaient tritronculaires. Quatre-vingt patients (78,6%) étaient insulino-nécessitant, l'Euro-score moyen était de 1,63±1% et le nombre moyen de pontage de 2,3±0,7. Les durées moyennes de la circulation extra-corporelle et du clampage aortique étaient respectivement de 134,4 ± 42 min et 76 ± 28 min. La mortalité hospitalière était de 2 décès (1,9%), les durées moyennes de ventilation artificielle, du séjour en réanimation et du séjour postopératoire étaient respectivement de 7h (5-16h), 48h (42-52h) et 15,6 ± 8,6 jours. Les complications postopératoires étaient l'infarctus du myocarde, l'infection de paroi, la médiastinite et le bas débit cardiaque chez respectivement 1,9%, 10,7%, 3,9% et 1,9% des patients. Il ressort de notre étude, que les facteurs prédictifs d'infection post opératoire étaient la durée de ventilation artificielle (p = 0,002), la durée de la circulation extra-corporelle (p < 0,001) en plus du tabac (p = 0,004) et de l'obésité (p = 0,005). Les patients ont été contactés par téléphone ou lors de la consultation régulière de contrôle. Le taux de suivi a atteint 92,1% et la survie à 2 ans était de 98,9% des patients contrôlés avec une mortalité tardive de 1% avec un décès suite à un accident vasculaire c

  18. Honest signaling in domestic piglets (Sus scrofa domesticus): vocal allometry and the information content of grunt calls

    PubMed Central

    Wondrak, Marianne; Huber, Ludwig; Fitch, W. Tecumseh

    2016-01-01

    ABSTRACT The information conveyed in acoustic signals is a central topic in mammal vocal communication research. Body size is one form of information that can be encoded in calls. Acoustic allometry aims to identify the specific acoustic correlates of body size within the vocalizations of a given species, and formants are often a useful acoustic cue in this context. We conducted a longitudinal investigation of acoustic allometry in domestic piglets (Sus scrofa domesticus), asking whether formants of grunt vocalizations provide information concerning the caller's body size over time. On four occasions, we recorded grunts from 20 kunekune piglets, measured their vocal tract length by means of radiographs (X-rays) and weighed them. Controlling for effects of age and sex, we found that body weight strongly predicts vocal tract length, which in turn determines formant frequencies. We conclude that grunt formant frequencies could allow domestic pigs to assess a signaler's body size as it grows. Further research using playback experiments is needed to determine the perceptual role of formants in domestic pig communication. PMID:27059064

  19. Infection dynamics of Torque teno sus virus types 1 and 2 in serum and peripheral blood mononuclear cells.

    PubMed

    Tshering, Chenga; Takagi, Mitsuhiro; Deguchi, Eisaburo

    2012-04-01

    This study was carried out to investigate the presence of Torque teno sus virus types 1 (TTSuV1) and 2 (TTSuV2) in a longitudinally (14 to 150 days of age) collected paired pooled sera (pSE) and peripheral blood mononuclear cells (pPBMCs) using nested polymerase chain reaction. The detection rate of TTSuV1 in pSE increased from 14 to 90 days of age, but a progressive decline was observed from 120 to 150 days of age, while in pPBMC, a high value was maintained till the end of growing-finishing period. On the contrary, except in PBMCs at 30 days of age, high detection rates of TTSuV2 were found in both pSE and pPBMCs in all sampling ages. The detection rate of TTSuVs between pSE and pPBMCs was positively correlated at all sampling ages except for TTSuV1 at 150 days of age. This is the first study showing the presence of TTSuVs in PBMCs from pigs and describing the in vivo infection dynamics of TTSuV in paired sera and PBMCs during the entire growing and finishing periods of pigs reared in conventional farms.

  20. Prevalence and diversity of Encephalitozoon spp. and Enterocytozoon bieneusi in wild boars (Sus scrofa) in Central Europe.

    PubMed

    Němejc, Karel; Sak, Bohumil; Květoňová, Dana; Hanzal, Vladimír; Janiszewski, Paweł; Forejtek, Pavel; Rajský, Dušan; Kotková, Michaela; Ravaszová, Petra; McEvoy, John; Kváč, Martin

    2014-02-01

    From 2011 to 2012, the occurrence of Enterocytozoon bieneusi and Encephalitozoon spp. was surveyed at 29 randomly selected localities (both forest areas and enclosures) across four Central European countries: Austria, the Czech Republic, Poland, and the Slovak Republic. Isolates were genotyped by PCR amplification and characterization of the internal transcribed spacer (ITS) region using Enterocytozoon and Encephalitozoon-specific protocols. PCR revealed 16 mono-infections of Encephalitozoon cuniculi, 33 mono-infections of Enterocytozoon bieneusi and 5 concurrent infections of both Encephalitozoon cuniculi and Enterocytozoon bieneusi out of 460 faecal samples. Two genotypes (I and II) were revealed by sequence analysis of the ITS region of Encephalitozoon cuniculi. Eleven genotypes, five previously found in other hosts including domestic pigs (D, EbpA, EbpC, G and Henan-I) and six novel (WildBoar1-6), were identified in Enterocytozoon bieneusi. No other microsporidia infection was found in the examined faecal samples. Prevalence of microsporidia at the locality level ranged from 0 to 58.8 %; the prevalence was less than 25 % at more than 86 % of localities. Enterocytozoon bieneusi was detected as a predominant species infecting Eurasian wild boars (Sus scrofa). The present report is the most comprehensive survey of microsporidia infections in wild boars within the Czech Republic and selected Central European countries.

  1. Substitution within erythropoietin receptor gene D1 domain associated with litter size in Beijing Black pig, Sus scrofa.

    PubMed

    Zhang, Longchao; Wang, Ligang; Li, Yong; Li, Wen; Yan, Hua; Liu, Xin; Zhao, Kebin; Wang, Lixian

    2011-10-01

    Studies of uterine capacity and litter size in swine have suggested that erythropoietin receptor (EPOR) plays an important role in fetal survival through maturation of red blood cells. In this study, we screened the porcine EPOR gene for mutations and identified three single nucleotide polymorphisms (SNPs): two missense mutations and one synonymous mutation. We then genotyped 272 Beijing Black sows, Sus scrofa, and compared this data with litter sizes from a total of 1523 parities among the sows. The G allele of the nonsynonymous SNP, EPOR c.434A>G, was associated with greater litter size at both first parity (P < 0.05) and at later parities (P < 0.01). This SNP causes His92Arg adjacent to the fourth conserved cysteine residue in the mature protein and is in the D1 domain of the protein. Additionally, we determined the allele frequencies for this SNP among six Chinese indigenous pig breeds (Bamei, Erhualian, Laiwu Black, Mashen, Meishan and Min) and three Western commercial pig breeds (Duroc, Landrace and Large White). The c.434G allele was significantly more common among the more prolific Chinese breeds than the Western breeds, implying that EPOR c.434A>G could be a useful genetic marker to improve litter size in swine.

  2. A comparative study of biochemical and immunological properties of triosephosphate isomerase from Taenia solium and Sus scrofa.

    PubMed

    Jiménez, Lucía; Fernández-Velasco, D Alejandro; Willms, Kaethe; Landa, Abraham

    2003-04-01

    We produced the Taenia solium triosephosphate isomerase (TPI) in Escherichia coli and compared its biochemical and immunological properties with those of the commercial TPI from Sus scrofa. Taenia solium TPI is a homodimer composed of two 27-kDa monomers, with a specific activity of 5,683 U/mg and a Km value of 0.758, and S. scrofa TPI is also dimeric with similar monomeric molecular weight, specific activity of 4,227 U/mg, and a Km value of 0.51. The catalytic parameters for the isomerization of glyceraldehyde 3-phosphate, affinity between TPI monomers, and kinetic thermal denaturation and inactivation were similar for both enzymes. Anti-T. solium TPI antibodies cross-react weakly with Schistosoma mansoni TPI but do not cross-react with S. scrofa, human, or protozoan TPIs. These antibodies inhibited T. solium TPI activity but did not affect S. scrofa enzymatic activity. Immunizations with 1 microg of the T. solium TPI reduced 52% of cysticerci in a mouse-Taenia crassiceps model 1 mo after challenge. Our findings show that T. solium and S. scrofa TPIs possess similar biochemical and enzymatic properties but do not share immunological properties because anti-T. solium TPI antibodies did not recognize S. scrofa TPI. Inhibition of enzyme activity by anti-TPI antibodies suggests that they can be used as inhibitors of the enzyme.

  3. Vegetable and animal food sorts found in the gastric content of Sardinian Wild Boar (Sus scrofa meridionalis).

    PubMed

    Pinna, W; Nieddu, G; Moniello, G; Cappai, M G

    2007-06-01

    Authors report results emerging from gastric content analysis from n. 96 wild boars hunted in Sardinia isle, during the hunting tide (2001-2005), from November to January. Mean pH of the gastric content was 3.77 +/- 0.69. Mean total capacity (TC) of each stomach was 1702 +/- 680 g. Mean Stuff ratio (CW/TC) between the content weight (CW) and stomachs TC was 0.45. Food categories found in animal stomachs were: 19 categories of vegetal species (Allium spp., Arbutus unedo, Arisarum vulgare, Avena fatua, Avena sativa, Castanea sativa, Ceratonia siliqua, Chamaerops umilis, Cichorium intybus, Hordeum sativum, Juniperus oxycedrus, Myrtus communis, Olea europea, Pirus amygdaliformis, Pistacia lentiscus, Quercus spp., Rhamnus alaternus, Triticum durum, Zea mais); 11 categories of animal species (Agriotes lineatus, Apodemus sylvaticus dicrurus, Chalcides chalcides, Chalcides ocellatus tiligugu, Crematogaster scutellaris, Forficula auricularia, Helix aspersa, Lumbricus terrestris, Ovis aries, Podarcis tiliguerta tiliguerta, Scolopendra cingulata); three categories were identified in general terms (insects larvae, hairs of mammals, feathers of birds). Food categories found in the stomach contents of Sus scrofa meridionalis confirm observations by other researchers who report the prevalence of vegetables in spite of animal food sorts in the wild boar diet in Italian regions.

  4. Experimental research on micro-pit defects of SUS 430 stainless steel strip in cold rolling process

    NASA Astrophysics Data System (ADS)

    Li, Changsheng; Li, Miao; Zhu, Tao; Huo, Gang

    2013-05-01

    In order to improve surface glossiness of stainless steel strip in tandem cold rolling, experimental research on micro-pit defects of SUS 430 ferrite stainless steel was investigated in laboratory. The surface morphology of micro-pit defects was observed by SEM. The effects of micro-pit defects on rolling reduction, roll surface roughness and emulsion parameters were analyzed. With the pass number increasing, the quantity and surface of micro-pit defects were reduced, uneven peak was decreased and gently along rolling direction, micro-pit defects had equally distributed tendency along tranverse direction. The micro-pit defects were increased with the roll surface roughness increase. The defects ratio was declined with larger gradient at pass number 1 to 3, but gentle slope at pass number 4 to 5. The effects of temperature 55° and 63°, concentration 3% and 6% of emulsion on micro-pit effects had not obvious difference. Maintain of micro-pit was effected by rolling oil or air in the micro-pit, the quality of oil was much more than the air in the micro-pit in lubrication rolling.

  5. Novel Technique for Retroperitoneal Implantation of Telemetry Transmitters for Physiologic Monitoring in Göttingen Minipigs (Sus scrofa domesticus)

    PubMed Central

    Willens, Scott; Cox, David M; Braue, Ernest H; Myers, Todd M; Wegner, Matthew D

    2014-01-01

    Telemetric monitoring of physiologic parameters in animal models is a critical component of chemical and biologic agent studies. The long-term collection of neurobehavioral and other physiologic data can require larger telemetry devices. Furthermore, such devices must be implanted in a location that is safe, well-tolerated, and functional. Göttingen minipigs (Sus scrofa domesticus) present an ideal large animal model for chemical agent studies due to their relatively small size, characterized health status, and ease of training and handling. We report an effective approach to implanting a novel device to measure transthoracic impedance to approximate respiratory tidal volume and rate in Suidae. We tested the approach using 24 male Göttingen minipigs. A ventral midline abdominal incision extending from the umbilicus to the prepuce was followed by a paramedian incision of the parietal peritoneum and dorsal blunt dissection to create a retroperitoneal pocket. The device was anchored inside the pocket to the internal abdominal musculature with 3-0 nonabsorbable suture, biopotential leads were routed through the abdominal musculature, and the pocket was closed with 3-0 absorbable suture. Paired biopotential leads were anchored intermuscularly at the level of the seventh rib midway between spine and sternum bilaterally to provide surrogate data for respiratory function. Postoperative recovery and gross pathology findings at necropsy were used to assess safety and refine the surgical procedure. Results demonstrated that this procedure permitted effective monitoring of complex physiologic data, including transthoracic impedance, without negatively affecting the health and behavior of the animals. PMID:25527027

  6. Encoding of Situations in the Vocal Repertoire of Piglets (Sus scrofa): A Comparison of Discrete and Graded Classifications

    PubMed Central

    Tallet, Céline; Linhart, Pavel; Policht, Richard; Hammerschmidt, Kurt; Šimeček, Petr; Kratinova, Petra; Špinka, Marek

    2013-01-01

    Two important questions in bioacoustics are whether vocal repertoires of animals are graded or discrete and how the vocal expressions are linked to the context of emission. Here we address these questions in an ungulate species. The vocal repertoire of young domestic pigs, Sus scrofa, was quantitatively described based on 1513 calls recorded in 11 situations. We described the acoustic quality of calls with 8 acoustic parameters. Based on these parameters, the k-means clustering method showed a possibility to distinguish either two or five clusters although the call types are rather blurred than strictly discrete. The division of the vocal repertoire of piglets into two call types has previously been used in many experimental studies into pig acoustic communication and the five call types correspond well to previously published partial repertoires in specific situations. Clear links exist between the type of situation, its putative valence, and the vocal expression in that situation. These links can be described adequately both with a set of quantitative acoustic variables and through categorisation into call types. The information about the situation of emission of the calls is encoded through five call types almost as accurately as through the full quantitative description. PMID:23967251

  7. Zoonotic intestinal protozoan of the wild boars, Sus scrofa, in Persian Gulf’s coastal area (Bushehr province), Southwestern Iran

    PubMed Central

    Yaghoobi, Kambiz; Sarkari, Bahador; Mansouri, Majid; Motazedian, Mohammad Hossein

    2016-01-01

    Aim: Wild boars, Sus scrofa, are potential reservoirs of many zoonotic diseases, and there are a possibility of transmission of the zoonotic diseases from these animals to humans and also domestic animals. This study aimed to evaluate the protozoan contamination of wild boars in the Persian Gulf’s coastal area (Bushehr Province), southwestern Iran. Materials and Methods: A total of 25 crossbred boars were collected during a course of vertebrate pest control in Bushehr province, in 2013. Samples were collected from the gastrointestinal tracts of each boar in 5% formalin, Bouin’s solution, sodium acetate-acetic acid-formalin, and polyvinyl alcohol fixatives. Fixed stool smears examined by trichrome and Ziehl–Neelsen staining. Results: Each of the 25 wild boars was infected with at least one of the intestinal protozoans. The rate of contamination with intestinal protozoan was 64% for Balantidium coli, 76% for Iodamoeba sp., 52% for Entamoeba polecki, 44% for Blastocystis sp. and 8% for Chilomastix sp. No intestinal coccidian was detected in studied boars when the stool samples were evaluated by Ziehl–Neelsen staining method. Conclusion: Findings of this study demonstrated that wild boars in the Persian Gulf coastal area are contaminated by many protozoans, including zoonotic protozoan, which poses a potential risk to locals as well as the domestic animals of the area. PMID:27847411

  8. Characterization of glutathione S-transferases from Sus scrofa, Cydia pomonella and Triticum aestivum: their responses to cantharidin.

    PubMed

    Yang, Xue-Qing; Zhang, Ya-Lin

    2015-02-01

    Glutathione S-transferases (GSTs) play a key role in detoxification of xenobiotics in organisms. However, their other functions, especially response to the natural toxin cantharidin produced by beetles in the Meloidae and Oedemeridae families, are less known. We obtained GST cDNAs from three sources: Cydia pomonella (CpGSTd1), Sus scrofa (SsGSTα1), and Triticum aestivum (TaGSTf3). The predicted molecular mass is 24.19, 25.28 and 24.49 kDa, respectively. These proteins contain typical N-terminal and C-terminal domains. Recombinant GSTs were heterologously expressed in Escherichia coli as soluble fusion proteins. Their optimal activities are exhibited at pH 7.0-7.5 at 30 °C. Activity of CpGSTd1 is strongly inhibited by cantharidin and cantharidic acid, but is only slightly suppressed by the demethylated analog of cantharidin and cantharidic acid. Enzymatic assays revealed that cantharidin has no effect on SsGSTα1 activity, while it significantly stimulates TaGSTf3 activity, with an EC50 value of 0.3852 mM. Activities of these proteins are potently inhibited by the known GST competitive inhibitor: S-hexylglutathione (GTX). Our results suggest that these GSTs from different sources share similar structural and biochemical characteristics. Our results also suggest that CpGSTd1 might act as a binding protein with cantharidin and its analogs.

  9. Molecular detection of Anaplasma spp. in pangolins (Manis javanica) and wild boars (Sus scrofa) in Peninsular Malaysia.

    PubMed

    Koh, Fui Xian; Kho, Kai Ling; Panchadcharam, Chandrawathani; Sitam, Frankie Thomas; Tay, Sun Tee

    2016-08-30

    Anaplasma spp. infects a wide variety of wildlife and domestic animals. This study describes the identification of a novel species of Anaplasma (Candidatus Anaplasma pangolinii) from pangolins (Manis javanica) and Anaplasma bovis from wild boars (Sus scrofa) in Malaysia. Based on 16S rRNA gene sequences, Candidatus Anaplasma pangolinii is identified in a distinct branch within the family Anaplasmataceae, exhibiting the closest sequence similarity with the type strains of Anaplasma bovis (97.7%) and Anaplasma phagocytophilum (97.6%). The sequence also aligned closely (99.9%) with that of an Anaplasma spp. (strain AnAj360) detected from Amblyomma javanense ticks. The nearly full length sequence of the 16S rRNA gene derived from two wild boars in this study demonstrated the highest sequence similarity (99.7%) to the A. bovis type strain. Partial 16S rRNA gene fragments of A. bovis were also detected from a small population of Haemaphysalis bispinosa cattle ticks in this study. Our finding suggests a possible spread of two Anaplasma species in the Malaysian wildlife and ticks. The zoonotic potential of the Anaplasma species identified in this study is yet to be determined.

  10. [The trajectory of the national policy for the reorientation of professional training in health in the Unified Health System (SUS)].

    PubMed

    Dias, Henrique Sant'anna; Lima, Luciana Dias de; Teixeira, Márcia

    2013-06-01

    This paper examines the national policy and its antecedents for reorientation of professional health training implemented after 2003. It highlights landmarks and transformations in the course of policies between 1980 and 2010, elements of continuity and change and the connections between past and current policy initiatives. The study involved a review of the literature on the subject and document analysis supported by theoretical analysis of public policies, particularly historical institutionalism. The results point to four different moments during the trajectory of the policy, marked by changes in the initiatives of reorientation of higher education in health: antecedents; initial experiences; university protagonism; broadening and enhancement. As an element of continuity, there is the permanence of objects in the guiding principles advocated in the policies. The evidence of implementation expresses prospects of enhancement, with diversification of mobilized actors and organizations, and more projects implemented. The accumulated experience suggests structural maturity of the structural bases of action and the main changes relate to the enhancement of decision-making bodies of the SUS and the approximation to the process of decentralization and regionalization of national health policy.

  11. [Development and validation of a social vulnerability index applied to public policies of the Unified Health System (SUS)].

    PubMed

    Drachler, Maria de Lourdes; Lobato, Marcos Antônio de Oliveira; Lermen, José Inácio; Fagundes, Sandra; Ferla, Alcindo Antonio; Drachler, Carlos Wietzke; Teixeira, Luciana Barcellos; Leite, José Carlos de Carvalho

    2014-09-01

    The article outlines the development and initial validation of a Social Vulnerability Index (SVI) including five social determinants of risk to health and demonstrates its application in the financing of primary care by the Unified Health System (SUS) in the State of Rio Grande do Sul. Municipal indicators of vulnerability relating to poverty and population dispersion were obtained from the 2010 population census of the Brazilian Institute of Geography and Statistics. Both exploratory and confirmatory factor analysis suggests that the five items can constitute a reliable and acceptable measurement scale. The SVI-5 was then generated based on the first main component, measuring municipal inequalities in social vulnerability relating to poverty and population in the territory in Z-scores. The external validity of SVI-5 was examined in relation to health outcomes using DATASUS 2007-2011 data, revealing that infant mortality and hospitalizations for conditions treatable by primary care are greater in more vulnerable municipalities The results suggest that the SVI-5 is a valid measure of inequalities in social vulnerability between municipalities, applicable to socially equitable policies in health.

  12. Wild pigs (Sus scrofa) mediate large-scale edge effects in a lowland tropical rainforest in Peninsular Malaysia.

    PubMed

    Fujinuma, Junichi; Harrison, Rhett D

    2012-01-01

    Edge-effects greatly extend the area of tropical forests degraded through human activities. At Pasoh, Peninsular Malaysia, it has been suggested that soil disturbance by highly abundant wild pigs (Sus scrofa), which feed in adjacent Oil Palm plantations, may have mediated the invasion of Clidemia hirta (Melastomataceae) into the diverse tropical lowland rain forest. To investigate this hypothesis, we established three 1 km transects from the forest/Oil Palm plantation boundary into the forest interior. We recorded the distribution of soil disturbance by wild pigs, C. hirta abundance, and environmental variables. These data were analyzed using a hierarchical Bayesian model that incorporated spatial auto-correlation in the environmental variables. As predicted, soil disturbance by wild pigs declined with distance from forest edge and C. hirta abundance was correlated with the level of soil disturbance. Importantly there was no effect of distance on C. hirta abundance, after controlling for the effect of soil disturbance. Clidemia hirta abundance was also correlated with the presence of canopy openings, but there was no significant association between the occurrence of canopy openings and distance from the edge. Increased levels of soil disturbance and C. hirta abundance were still detectable approximately 1 km from the edge, demonstrating the potential for exceptionally large-scale animal mediated edge effects.

  13. Wild Pigs (Sus scrofa) Mediate Large-Scale Edge Effects in a Lowland Tropical Rainforest in Peninsular Malaysia

    PubMed Central

    Fujinuma, Junichi; Harrison, Rhett D.

    2012-01-01

    Edge-effects greatly extend the area of tropical forests degraded through human activities. At Pasoh, Peninsular Malaysia, it has been suggested that soil disturbance by highly abundant wild pigs (Sus scrofa), which feed in adjacent Oil Palm plantations, may have mediated the invasion of Clidemia hirta (Melastomataceae) into the diverse tropical lowland rain forest. To investigate this hypothesis, we established three 1 km transects from the forest/Oil Palm plantation boundary into the forest interior. We recorded the distribution of soil disturbance by wild pigs, C. hirta abundance, and environmental variables. These data were analyzed using a hierarchical Bayesian model that incorporated spatial auto-correlation in the environmental variables. As predicted, soil disturbance by wild pigs declined with distance from forest edge and C. hirta abundance was correlated with the level of soil disturbance. Importantly there was no effect of distance on C. hirta abundance, after controlling for the effect of soil disturbance. Clidemia hirta abundance was also correlated with the presence of canopy openings, but there was no significant association between the occurrence of canopy openings and distance from the edge. Increased levels of soil disturbance and C. hirta abundance were still detectable approximately 1 km from the edge, demonstrating the potential for exceptionally large-scale animal mediated edge effects. PMID:22615977

  14. Genetic variation of the East Balkan Swine (Sus scrofa) in Bulgaria, revealed by mitochondrial DNA and Y chromosomal DNA.

    PubMed

    Hirata, D; Doichev, V D; Raichev, E G; Palova, N A; Nakev, J L; Yordanov, Y M; Kaneko, Y; Masuda, R

    2015-04-01

    East Balkan Swine (EBS) Sus scrofa is the only aboriginal domesticated pig breed in Bulgaria and is distributed on the western coast of the Black Sea in Bulgaria. To reveal the breed's genetic characteristics, we analysed mitochondrial DNA (mtDNA) and Y chromosomal DNA sequences of EBS in Bulgaria. Nucleotide diversity (πn ) of the mtDNA control region, including two newly found haplotypes, in 54 EBS was higher (0.014 ± 0.007) compared with that of European (0.005 ± 0.003) and Asian (0.006 ± 0.003) domestic pigs and wild boar. The median-joining network based on the mtDNA control region showed that the EBS and wild boar in Bulgaria comprised mainly two major mtDNA clades, European clade E1 (61.3%) and Asian clade A (38.7%). The coexistence of two mtDNA clades in EBS in Bulgaria may be the relict of historical pig translocation. Among the Bulgarian EBS colonies, the geographical differences in distribution of two mtDNA clades (E1 and A) could be attributed to the source pig populations and/or historical crossbreeding with imported pigs. In addition, analysis of the Y chromosomal DNA sequences for the EBS revealed that all of the EBS had haplotype HY1, which is dominant in European domestic pigs.

  15. Enhancing the antimicrobial activity of Sus scrofa lysozyme by N-terminal fusion of a sextuple unique homologous peptide.

    PubMed

    Zhu, Dewei; Cai, Guolin; Li, Xiaomin; Lu, Jian; Zhang, Liang

    2017-02-10

    Sus scrofa lysozyme (SSL), an important component of the pig immune system, is a potential candidate to replace antibiotics in feed. However, there is little antimicrobial activity of natural SSL against gram-negative bacteria, which limits its application. In this study, a unique peptide (A-W-V-A-W-K) with antimicrobial activity against gram-negative bacteria was discovered and purified from trypsin hydrolysate of natural SSL. This unique peptide was fused to natural SSL and the recombinant fused SSL exhibited improved activity against gram-negative bacteria. The N-terminal fusion likely increased the membrane penetrability and induced programmed bacterial cell death. The recombinant fused SSL also showed higher activity against some gram-positive bacteria with O-acetylation. By N-terminal fusion of the sextuple peptide, the anti-microbial activity, either to gram-positive or negative bacteria, of the recombinant SSL was higher than the fusion of only one copy of the peptide. This study provides a general, feasible, and highly useful strategy to enhance the antimicrobial activity of lysozyme.

  16. On the evolutionary consequences of increasing litter size with multiple paternity in wild boar (Sus scrofa scrofa).

    PubMed

    Gayet, Thibault; Devillard, Sébastien; Gamelon, Marlène; Brandt, Serge; Say, Ludovic; Baubet, Eric

    2016-06-01

    Understanding how some species may be able to evolve quickly enough to deal with anthropogenic pressure is of prime interest in evolutionary biology, conservation, and management. Wild boar (Sus scrofa scrofa) populations keep growing all over Europe despite increasing hunting pressure. In wild boar populations subject to male-selective harvesting, the initially described polygynous mating system may switch to a promiscuous/polyandrous one. Such a change in the mating system, where potentially more males sire a litter at one reproductive event, may be associated with the retention of high genetic diversity and an increase of litter size. We tested these hypotheses by estimating the number of sires per litter based on a six-year long monitoring of a wild boar population subject to particularly high harvesting pressure. Our results show a high and stable genetic diversity and high rates of multiple paternity compared to other populations, thus depicting a promiscuous/polyandrous mating system in this population. We also show that litter size is positively linked to the number of sires, suggesting that multiple paternity increases fecundity. We finally discuss that multiple paternity may be one of the factors allowing rapid evolution of this population by maintaining both genetic and phenotypic diversity.

  17. Non-tuberculous mycobacteria in wild boar (Sus scrofa) from Southern Spain: epidemiological, clinical and diagnostic concerns.

    PubMed

    García-Jiménez, W L; Benítez-Medina, J M; Martínez, R; Carranza, J; Cerrato, R; García-Sánchez, A; Risco, D; Moreno, J C; Sequeda, M; Gómez, L; Fernández-Llario, P; Hermoso-de-Mendoza, J

    2015-02-01

    Non-tuberculous mycobacteria (NTM) are widely distributed in the environment, particularly in wet soil, marshland, rivers or streams, but also are causative agents of a wide variety of infections in animals and humans. Little information is available regarding the NTM prevalence in wildlife and their effects or significance in the bovine tuberculosis (bTB) epidemiology and diagnosis. This research shows the most frequently NTM isolated in lymph nodes of wild boar (Sus scrofa) from southern Spain, relating the NTM presence with the individual characteristics, the management of animals and the possible misdiagnosis of Mycobacterium bovis in concurrent infections. A total of 219 NTM isolates were obtained from 1249 wild boar mandibular lymph nodes sampled between 2007 and 2011. All but 75 isolates were identified by the PCR-restriction analysis-hsp65, and a partial sequencing of the 16S rDNA was carried out to identify the rest of the isolates. Results showed that Mycobacterium chelonae was the most frequently isolated NTM specie (133 isolates, 60.7%), followed by Mycobacterium avium (24 isolates, 11%). No relation was found regarding sex, body condition and management, but M. chelonae was more frequently detected in adults, whereas M. avium was more prevalent in subadults. The high NTM prevalence observed in the studied wild boar populations could make difficult the bTB diagnostic.

  18. CHARACTERIZATION OF PORCINE PARVOVIRUS TYPE 3 AND PORCINE CIRCOVIRUS TYPE 2 IN WILD BOARS (SUS SCROFA) IN SLOVAKIA.

    PubMed

    Sliz, Ivan; Vlasakova, Michaela; Jackova, Anna; Vilcek, Stefan

    2015-07-01

    As the number of free-living wild boars (Sus scrofa L.) continues to rise in Slovakia, the probability of pathogen transmission between susceptible species increases. We investigated the distribution and genetic characterization of porcine parvovirus type 3 (PPV3), porcine circovirus type 2 (PCV2), and their coinfection in wild boars. Among 194 animals tested, 19.1% were positive for PPV3 and 43.8% for PCV2. Similar rates of coinfection with both viruses reaching 11.0% and 11.8% were observed in juvenile and mature wild boars, respectively. Phylogenetic analysis of PPV3 sequences from VP1 and NS1 genomic regions revealed a close genetic relationship among isolates from Slovakia and those sampled worldwide. Prevalence of PCV2 in wild boars was lower than that reported in domestic pigs in Slovakia. The PCV2 variants originating from sylvatic and domestic hosts in Slovakia were grouped in the same clusters, namely PCV2b-1A/1B and PCV2a-2D.

  19. Evaluation of a Commercial ELISA for the Detection of Antibodies to Sarcoptes scabiei in Wild Boar (Sus scrofa).

    PubMed

    Haas, Chloé; Rossi, Sophie; Meier, Roman; Ryser-Degiorgis, Marie-Pierre

    2015-07-01

    Sarcoptic mange occurs in free-ranging wild boar (Sus scrofa) but has been poorly described in this species. We evaluated the performance of a commercial indirect enzyme-linked immunosorbent assay (ELISA) for serodiagnosis of sarcoptic mange in domestic swine when applied to wild boar sera. We tested 96 sera from wild boar in populations without mange history ("truly noninfected") collected in Switzerland between December 2012 and February 2014, and 141 sera from free-ranging wild boar presenting mange-like lesions, including 50 live animals captured and sampled multiple times in France between May and August 2006 and three cases submitted to necropsy in Switzerland between April 2010 and February 2014. Mite infestation was confirmed by skin scraping in 20 of them ("truly infected"). We defined sensitivity of the test as the proportion of truly infected that were found ELISA-positive, and specificity as the proportion of truly noninfected that were found negative. Sensitivity and specificity were 75% and 80%, respectively. Success of antibody detection increased with the chronicity of lesions, and seroconversion was documented in 19 of 27 wild boar sampled multiple times that were initially negative or doubtful. In conclusion, the evaluated ELISA has been successfully applied to wild boar sera. It appears to be unreliable for early detection in individual animals but may represent a useful tool for population surveys.

  20. Onchocerca takaokai n. sp. (Nematoda: Filarioidea) in Japanese wild boars (Sus scrofa leucomystax): Description and molecular identification of intradermal females.

    PubMed

    Uni, Shigehiko; Fukuda, Masako; Agatsuma, Takeshi; Bain, Odile; Otsuka, Yasushi; Nakatani, Jun; Matsubayashi, Makoto; Harada, Masashi; Omar, Hasmahzaiti; Ramli, Rosli; Hashim, Rosli; Azirun, Mohd Sofian; Takaoka, Hiroyuki

    2015-12-01

    Human zoonotic onchocercosis is caused by Onchocerca dewittei japonica, parasitic in wild boars (Sus scrofa leucomystax) in Japan. Previously, microfilariae longer than those of Onchocerca dewittei japonica were observed in skin snips from wild boars during the study of O. dewittei japonica. Moreover, the third-stage larvae (L3) of these longer microfilariae were obtained from the blackfly Simulium bidentatum after experimental injections. Based on morphometric and molecular studies, similar L3 were found in blackflies during fieldwork in Oita, Japan. However, except for O. dewittei japonica, adult worms of Onchocerca have not been found in wild boars. In this study, we discovered adult females of a novel Onchocerca species in the skin of a wild boar in Oita, and named it Onchocerca takaokai n. sp. Females of this new species had longer microfilariae and differed from O. dewittei japonica in terms of their morphological characteristics and parasitic location. The molecular characteristics of the cytochrome c oxidase subunit 1 and 12S rRNA genes of the new species were identical to those of the longer microfilariae and L3 previously detected, but they differed from those of O. dewittei japonica at the species level. However, both species indicated a close affinity among their congeners and Onchocerca ramachandrini, parasitic in the warthog in Africa, was basal in the Suidae cluster of the 12S rRNA tree.

  1. Evidence of leptospirosis in the kidneys and serum of feral swine (Sus scrofa) in the United States.

    PubMed

    Pedersen, K; Anderson, T D; Bevins, S N; Pabilonia, K L; Whitley, P N; Virchow, D R; Gidlewski, T

    2017-01-01

    Leptospirosis is the most widespread zoonosis in humans worldwide. In the United States, widespread detection of antibodies to leptospirosis have been identified in feral swine (Sus scrofa) with the highest detection of serovars, Bratislava, Icterohaemorrhagiae, and Pomona. Over the past few years, feral swine populations have expanded their geographical range and distribution in the United States with reports in at least 39 of 50 states. Since feral swine serve as reservoirs for serovars that can infect humans, it is important to understand the risk of transmission. In order to learn more about the probability that feral swine shed infectious leptospires, we collected kidneys and paired serum when possible from 677 feral swine in 124 counties of 29 states. These counties had previously been identified as antibody positive for Leptospira interrogans serovars Bratislava, Canicola, Grippotyphosa, Hardjo, Icterohaemorrhagiae or Pomona. Although exposure to these same six serovars of leptospirosis continued to be high (53% overall) in the counties we sampled, we detected leptospiral DNA in only 3·4% of feral swine kidneys tested. Based on these results, it appears that although feral swine can serve as a source of infection to humans, especially in those who are more likely to encounter them directly such as wildlife biologists, veterinarians, and hunters, the risk may be relatively low. However, further studies to examine the relationship between leptospiral shedding in the urine and kidneys in addition to culturing the organism are recommended in order to better understand the risk associated with feral swine.

  2. Survey of Feral Swine ( Sus scrofa ) Infection with the Agent of Chagas Disease ( Trypanosoma cruzi ) in Texas, 2013-14.

    PubMed

    Comeaux, Juliette M; Curtis-Robles, Rachel; Lewis, Barbara C; Cummings, Kevin J; Mesenbrink, Brian T; Leland, Bruce R; Bodenchuk, Michael J; Hamer, Sarah A

    2016-07-01

    : Feral swine ( Sus scrofa ) are an invasive species and reservoir of numerous zoonotic pathogens in the US, and Texas leads the nation in the estimated population size of feral hogs. Texas also harbors enzootic transmission cycles of the protozoan parasite Trypanosoma cruzi , agent of Chagas disease. Given previous evidence that swine can serve as reservoirs of T. cruzi in Latin America and new evidence of triatomines (kissing bugs) feeding on swine in Texas, we measured the prevalence of T. cruzi infection in feral swine in Texas. From 2013 to 2014, we sampled blood and/or cardiac tissue from 78 feral swine across 14 Texas counties (seven with and seven without prior documentation of kissing bug occurrence) and used PCR and histopathology to detect T. cruzi infection. We determined an overall infection prevalence of 6% (3 of 54) based on PCR evaluation of cardiac tissue, and no blood samples were positive (n=72). All three positive pigs were from counties where kissing bugs are documented. No T. cruzi amastigotes were noted on histopathology (n=54). Sarcocysts were observed in 10 (18%) of the samples, five of which also had mild focal areas of degeneration and inflammatory cell infiltration. Eco-epidemiologic investigations can provide an assessment of contributions of feral hogs to maintenance of T. cruzi across a landscape to help protect human and animal health.

  3. A Taphonomic Study Exploring the Differences in Decomposition Rate and Manner between Frozen and Never Frozen Domestic Pigs (Sus scrofa).

    PubMed

    Roberts, Lindsey G; Dabbs, Gretchen R

    2015-05-01

    This research examined differences in decomposition rate and manner of domestic pig subjects (Sus scrofa) in never frozen (control) and previously frozen (experimental) research conditions. Eight control and experimental subjects were placed in an identical outdoor research environment. Daily quantitative and qualitative measurements were collected: abdominal circumference, total body score (TBS), temperature, photographs, descriptive decomposition stages, and visual observations. Field necropsies were performed at accumulated degree days (ADD) between 50 and 300 (Celsius). Paired samples t-tests of ADD to TBS >3.0, TBS >9.5, and TBS >16.0 indicate the rate of decomposition of experimental subjects was significantly slower than controls at both TBS >3 and >9.5 (p = 0.003 and p = 0.002, respectively). A suite of qualitative indicators of predecomposition freezing is also reported. The differences between experimental and control subjects suggest previously frozen subjects should not be used in taphonomic research, as results do not accurately reflect the "normal" taphonomic condition.

  4. Mesenteric lymph node granulomatous lesions in naturally infected wild boar (Sus scrofa) in Portugal--Histological, immunohistochemical and molecular aspects.

    PubMed

    Matos, A C; Andrade, S; Figueira, L; Matos, M; Pires, M A; Coelho, A C; Pinto, M L

    2016-05-01

    Several studies have demonstrated that wildlife reservoirs of mycobacteria are responsible for the maintenance and spreading of the infection to livestock and wildlife counterparts. Recent data report the role of wild boar (Sus scrofa) as a reservoir for Mycobacterium bovis. This study was conducted to evaluate the chronic inflammatory response in the mesenteric lymph nodes (MLN) of wild boar with granulomatous lymphadenitis (n=30). Morphological parameters of the lesions were recorded. The expression of CD3 and CD79α molecules was evaluated by immunohistochemistry. Molecular genotyping and culture to identify mycobacteria were performed. The lesions consisted mainly of stage III and stage IV granulomas. CD3 and CD79α positive cells were observed in 15 (50%) and in 11 (36.6%) MLN, respectively. In these lesions, higher percentages of T lymphocytes were found and a limited number of animals exhibited a tendency for an increased percentage of B lymphocytes. Our results suggest that there are similar percentages and distribution patterns of CD3 and CD79α in the lesions, regardless of the presence of Mycobacterium avium subsp. paratuberculosis (Map), M. bovis or Map-M. bovis co-infection, and confirm that wild boar is both susceptible and could be an important Map and M. bovis wild reservoir in the study area.

  5. Pseudorabies Virus and Brucella abortus from an Expanding Wild Pig ( Sus scrofa ) Population in Southern Oklahoma, USA.

    PubMed

    Gaskamp, Joshua A; Gee, Kenneth L; Campbell, Tyler A; Silvy, Nova J; Webb, Stephen L

    2016-04-28

    Wild pigs ( Sus scrofa ) are causing increasing ecologic and economic damage at a global scale. Because wild pigs can carry ≥65 diseases that affect livestock, their widespread expansion threatens native wildlife and livestock. We screened wild pigs from south-central Oklahoma, US for antibodies against Brucella abortus , pseudorabies virus (PRV), and porcine reproductive and respiratory syndrome virus (PRRS). These pathogens were chosen because they are part of eradication programs in the US and could have large economic impacts on domestic livestock if transmitted from wild animals. We tested 282 serum samples during spring 2010 (n=149) and 2011 (n=133) and found an overall exposure rate to PRV of 24.1% (n=68); PRV was detected at two of three study sites. Two wild pigs had detectable antibody to B. abortus , and one had detectable antibody to PRRS. On average, 27% of wild pigs within a sounder were positive for PRV antibody, with 44% of the sounders (16/36) having at least one positive individual. These data highlight that wild pigs could carry pathogens that affect domestic livestock. Because the US is free of these pathogens in commercial livestock operations, continued surveillance and vaccination of domestic livestock are needed. Commercial livestock producers at the wildlife-livestock interface may benefit from spatial prioritization of risk zones to facilitate strategic control efforts.

  6. The first report on Cryptosporidium suis and Cryptosporidium pig genotype II in Eurasian wild boars (Sus scrofa) (Czech Republic).

    PubMed

    Němejc, Karel; Sak, Bohumil; Květoňová, Dana; Hanzal, Vladimír; Jeníková, Martina; Kváč, Martin

    2012-03-23

    A total of 193 faecal samples of adult Eurasian wild boars were collected at 12 enclosures across the Czech Republic and examined for Cryptosporidium infection using both microscopic and molecular tools. Cryptosporidium oocysts were not detected in any of the 193 faecal samples examined using the aniline-carbol-methyl violet staining method. Thirty-two positive cases of Cryptosporidium infection were detected using either genus- or species-specific nested PCR. Mono-infection with Cryptosporidium suis and Cryptosporidium pig genotype II were found in 13 and 7 cases, respectively. Five mixed infections of C. suis and Cryptosporidium pig genotype II were detected using PCR/RFLP with genus specific primers. The number of detected mixed infections increased 2.4 fold when a species-specific PCR was employed. No other Cryptosporidium spp. was detected. Unlike cryptosporidiosis of domestic pigs, C. suis was detected as a dominant species infecting adult Eurasian wild boars. There was no association between diarrhoea and the presence of Cryptosporidium infection in the Eurasian wild boars studied. This is the first report on the Cryptosporidium infection caused by C. suis and Cryptosporidium pig genotype II in Eurasian wild boars (Sus scrofa).

  7. Globalisation and global trade influence molecular viral population genetics of Torque Teno Sus Viruses 1 and 2 in pigs.

    PubMed

    Cortey, Martí; Pileri, Emanuela; Segalés, Joaquim; Kekarainen, Tuija

    2012-04-23

    Globalisation, in terms of the rapid and free movement of people, animals and food, has created a new paradigm, increasing the range and rate of distribution of many pathogens. In the present study, Torque teno sus viruses (TTSuVs) have been used as a model to evaluate the effects of global trade on viral heterogeneity, and how the movement of live pigs can affect the distribution and composition of virus populations. Seventeen countries from different parts of the world have been screened for TTSuV1 and TTSuvV2. High levels of genetic diversity have been found as well as two new TTSuV subtypes. A small fraction of this diversity (<5%) was related with spatial structure; however the majority (>50%) was best explained by the exchange of live pigs among countries, pointing to the direct relationship between the movement of hosts and the diversity of their accompanying viruses. Taking TTSuVs as sentinels, this study revealed that the distribution and diversity of comensal microflora in live animals subjected to global trade is shaped by the commercial movements among countries. In the case of TTSuVs, it appears that commercial movements of animals are eroding the genetic composition of the virus populations that may have been present in pig herds since their domestication.

  8. Les bisphosphonates dans le traitement de l’ostéoporose

    PubMed Central

    Brown, Jacques P.; Morin, Suzanne; Leslie, William; Papaioannou, Alexandra; Cheung, Angela M.; Davison, Kenneth S.; Goltzman, David; Hanley, David Arthur; Hodsman, Anthony; Josse, Robert; Jovaisas, Algis; Juby, Angela; Kaiser, Stephanie; Karaplis, Andrew; Kendler, David; Khan, Aliya; Ngui, Daniel; Olszynski, Wojciech; Ste-Marie, Louis-Georges; Adachi, Jonathan

    2014-01-01

    Résumé Objectif Exposer l’efficacité et les risques du traitement par les bisphosphonates dans la prise en charge de l’ostéoporose et décrire les patients qui seraient de bons candidats aux congés thérapeutiques. Qualité des données Une recherche dans MEDLINE (PubMed, jusqu’au 31 décembre 2012) a permis de relever les publications pertinentes pour l’inclusion. La plupart des données probantes citées sont de niveau II (tirées d’essais non randomisés, de cohorte et d’autres essais comparatifs). Message principal L’efficacité des bisphosphonates de premier recours homologués pour la prévention des fractures a été éprouvée dans le cadre d’essais cliniques randomisés et contrôlés. Cependant, l’usage clinique répandu et prolongé des bisphosphonates a donné lieu à des rapports de manifestations indésirables rares, mais graves. L’ostéonécrose maxillaire et les fractures atypiques sous-trochantériennes ou diaphysaires du fémur seraient liées à l’emploi des bisphosphonates dans le traitement de l’ostéoporose, mais ces manifestations sont extrêmement rares et lorsqu’elles surviennent, elles sont accompagnées d’autres comorbidités ou de l’emploi concomitant de médicaments. Les congés thérapeutiques ne peuvent être envisagés que chez les patients à faible risque et dans un groupe restreint de patients dont le risque de fracture est modéré après un traitement de 3 à 5 ans. Conclusion Lorsque les bisphosphonates sont prescrits à des patients dont le risque de fracture est élevé, leur effet de prévention des fractures l’emporte de loin sur leurs torts potentiels. Chez les patients qui prennent des bisphosphonates depuis 3 à 5 ans, il faut réévaluer le besoin de poursuivre le traitement.

  9. Le HELLP syndrome: à propos de 61 cas et revue de la littérature

    PubMed Central

    Mamouni, Nisrine; Bougern, Hakima; Derkaoui, Ali; Bendahou, Karima; Fakir, Samira; Bouchikhi, Chehrazad; Chaara, Hikmat; Banani, Abdelaziz; Abdelilah, Moulay Melhouf

    2012-01-01

    Introduction L’objectif de ce travail etait d’étudier et comparer les paramètres épidémiologiques, cliniques, paracliniques et évolutifs des patientes présentant un HELLP syndrome complet et incomplet. (Hemolysis, Elevated Liver enzymes, Low Platelets count). Méthodes Une enquête rétrospective sur la période du 1er janvier 2005 au 31octobre 2008 et incluant tous les cas de HELLP syndrome colligés au service de Gynécologie obstétrique du CHU HASSAN II de Fès, incluant toutes les patientes ayant présenté un HELLP syndrome. Les patientes ont été classées en deux groupes en fonction de la forme du HELLP syndrome (complète ou incomplète). Résultats 61 patientes ont été incluses, dont 29 ont présenté un HELLP syndrome complet (groupe 1) et 32 ont présenté une forme incomplète de ce syndrome (groupe 2). La moyenne d’âge était de 29,7 ± 7 ans pour le groupe 1 et de 28,5 ± 7 ans pour le groupe 2.La gestité moyenne était de 2,8, Pour le groupe 1et de 2,5 pour le groupe 2.Les complications maternelles ont été notées chez 68,9% des patientes avec HELLP complet et 53% avec HELLP incomplet. On a recensés trois cas de décès maternel dans le groupe HELLP complet contre aucun cas dans la forme incomplète. Conclusion D’après les résultats de notre étude, le HELLP complet n’expose pas les patientes à un risque plus élevé de complications maternelles que dans la forme incomplète. PMID:22514764

  10. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    PubMed Central

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  11. Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

    PubMed Central

    Yang, David Yi; Bracken, Keyna

    2016-01-01

    Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

  12. 2l-nl{prime} x-ray transitions from neonlike charge states of the row 5 metals with 39 {le} Z {le} 46

    SciTech Connect

    Rice, J.E.; Terry, J.L.; Marmar, E.S.; Fournier, K.B.; Goldstein, W.H.; Finkenthal, M.; Safronova, U.I.

    1996-03-18

    X-ray spectra of 2l-2l{prime} transitions with 3 {le} n {le} 12 in the row five transition metals zirconium (Z = 40), niobium (Z = 41), molybdenum (Z = 42) and palladium (Z = 46) from charge states around neonlike have been observed from Alcator C-Mod plasmas. Accurate wavelengths ({+-} .2 m{angstrom}) have been determined by comparison with neighboring argon, chlorine and sulfur lines with well known wavelengths. Line identifications have been made by comparison to ab initio atomic structure calculations, using a fully relativistic, parametric potential code. For neonlike ions, calculated wavelengths and oscillator strengths are tabulated for 2p-nd transitions in Y (Z = 39), Tc (Z = 43), Ru (Z = 44) and Rh (Z = 45) with n = 6 and 7. The magnitude of the configuration interaction between the (2p{sup 5}){sub 1/2}6d{sub 3/2} J = 1 level and the (2p{sup 5}){sub 3/2}7D{sub 5/2} J = 1 levels is demonstrated as a function of atomic number for successive neonlike ions. Measured spectra of selected transitions in the aluminum-, magnesium-, sodium- and fluorine like isosequences are also shown.

  13. Are bioresorbable polylactate devices comparable to titanium devices for stabilizing Le Fort I advancement?

    PubMed

    Blakey, G H; Rossouw, E; Turvey, T A; Phillips, C; Proffit, W R; White, R P

    2014-04-01

    The purpose of this study was to evaluate whether skeletal and dental outcomes following Le Fort I surgery differed when stabilization was performed with polylactate bioresorbable devices or titanium devices. Fifty-seven patients with preoperative records and at least 1 year postoperative records were identified and grouped according to the stabilization method. All cephalometric X-rays were traced and digitized by a single operator. Analysis of covariance was used to compare the postsurgical change between the two stabilization methods. Twenty-seven patients received bioresorbable devices (group R), while 30 received titanium devices (group M). There were no statistically significant differences between the two groups with respect to gender, race/ethnicity, age, or dental and skeletal movements during surgery. Subtle postsurgical differences were noted, but were not statistically significant. Stabilization of Le Fort I advancement with polylactate bioresorbable and titanium devices produced similar clinical outcomes at 1 year following surgery.

  14. La prise en charge d’une clientèle

    PubMed Central

    Roy, Andréanne; Breton, Mylaine; Loslier, Julie

    2016-01-01

    Résumé Objectif Analyser les facteurs qui incitent les médecins de famille nouvellement autorisés à faire de la prise en charge d’une clientèle en première ligne. Type d’étude Devis mixte séquentiel : questionnaire en ligne auto-administré auprès de médecins de famille, suivi d’entrevues individuelles. Contexte La Montérégie, qui est la deuxième région la plus populeuse du Québec, et qui présente des zones rurales et urbaines. Participants Tous les médecins de famille détenant un poste en Montérégie et ayant moins de 10 années d’expérience ont été sollicités, soit 366 médecins. Parmi eux, 118 ont complété le questionnaire en ligne (taux de réponse de 32,2 %). Parmi les répondants, 10 médecins ayant des profils de prise en charge variés ont été sélectionnés pour les entrevues individuelles. Principaux paramètres à l’étude Le pourcentage de temps de travail consacré à la prise en charge, analysé en parallèle avec différents facteurs facilitants et barrières à la prise en charge aux niveaux contextuel, organisationnel, du médecin de famille et de la clientèle. Résultats Les principaux facteurs facilitant la prise en charge sont la relation médecin-patient, l’intérêt pour les activités cliniques liées à la prise en charge, les modèles de rôles positifs, la collaboration avec une infirmière et l’accès adéquat aux ressources, notamment en santé mentale. Les principales barrières sont l’ampleur des tâches administratives, l’intérêt pour une pratique polyvalente, l’expérience négative de la prise en charge lors de la formation, un sentiment n’inaptitude à l’égard de la prise en charge, la lourdeur de la clientèle et le manque de soutien en début de pratique. Conclusion Certaines pistes de solution pour inciter les nouveaux médecins de famille à prendre en charge une clientèle sont proposées. Des points d’amélioration au niveau de la formation médicale, du soutien

  15. Le chondrome extra osseux de la cuisse: une localisation exceptionnelle (à propos d'un cas)

    PubMed Central

    Chafry, Bouchaib; Sasbou, Youness; Boussaidane, Mohammed; Nkaoui, Mustafa; Benchebba, Driss; Chagar, Belkacem

    2015-01-01

    Le chondrome extra-osseux est une tumeur cartilagineuse bénigne et rare. Il siège généralement au niveau des extrémités, nous rapportons un cas exceptionnel d'un chondrome des parties molles de la cuisse chez un homme de 35 ans qui s'est manifesté par une tuméfaction douloureuse de la face interne de la cuisse droite. L'histologie a confirmé le diagnostic sur la pièce d'exérèse. Un suivi clinique et radiologique après un recul de 24 mois n'a pas objectivé de signe de récidive. PMID:26405480

  16. Le Fort II midfacial distraction combined with orthognathic surgery in the treatment of nasomaxillary hypoplasia.

    PubMed

    Yu, Hongbo; Dai, Jiewen; Wang, Xudong; Zhang, Wenbin; Shen, Steve Guofang

    2014-05-01

    Patients with nasomaxillary hypoplasia have severe facial concavity and compromised skeletal class III malocclusion. Its treatment is still a challenge to surgeons. Our aim was to evaluate the combination of midfacial distraction and orthognathic surgery in the treatment of nasomaxillary hypoplasia. Four patients with nasomaxillary hypoplasia were enrolled in this study. After Le Fort II osteotomy, the rotational distraction of nasomaxillary complex was performed to rehabilitate facial convexity. Then bilateral sagittal split ramus osteotomy with or without Le Fort I osteotomy was used to correct malocclusion. All patients healed uneventfully, and the maxillae moved forward conspicuously. No obvious pain and severe discomfort were complained during distraction. A significant advancement and downward movement of the maxilla were shown by cephalometric analysis. The combination of midfacial distraction and orthognathic surgery provides us an ideal alternative in the treatment of nasomaxillary hypoplasia.

  17. Dandy-Walker syndrome with severe velopharyngeal dysfunction: a contraindication for Le Fort I surgery?

    PubMed

    Nelke, Kamil H; Pawlak, Wojciech; Gerber, Hanna

    2015-01-01

    Dandy-Walker syndrome is a rare congenital brain deformation. Most symptoms are related with fourth ventricle and skull base malformations. Quite often, symptoms develop from infancy or progress rapidly. Cerebellar dysfunction, lack of muscle coordination, and skull deformities involving eye movement might be present. There are several Dandy-Walker syndrome complex types. We present a 23-year-old patient who had a severe dentofacial deformity with mandibular prognathism and extremely undeveloped maxillary bone resulting in palatopharyngeal and velopharyngeal dysfunction with complete lack of soft palate function resulting in increased speech tone and volume. Performing Le Fort I osteotomy in this case is greatly controversial and might result in even greater loss of function or even its total lack. Velopharyngeal complex is very important, and every surgeon should consider its value while planning Le Fort I osteotomies.

  18. The Potassium-Argon Laser Experiment (KArLE): In Situ Geochronology for Planetary Robotic Missions

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara

    2016-01-01

    The Potassium (K) - Argon (Ar) Laser Experiment (KArLE) will make in situ noble-gas geochronology measurements aboard planetary robotic landers and roverss. Laser-Induced Breakdown Spectroscopy (LIBS) is used to measure the K abun-dance in a sample and to release its noble gases; the evolved Ar is measured by mass spectrometry (MS); and rela-tive K content is related to absolute Ar abundance by sample mass, determined by optical measurement of the ablated volume. KArLE measures a whole-rock K-Ar age to 10% or better for rocks 2 Ga or older, sufficient to resolve the absolute age of many planetary samples. The LIBS-MS approach is attractive because the analytical components have been flight proven, do not require further technical development, and provide complementary measurements as well as in situ geochronology.

  19. Magnétométrie à hélium par pompage laser: le bilan

    NASA Astrophysics Data System (ADS)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  20. An Update on Midface Advancement Using Le Fort II and III Distraction Osteogenesis

    PubMed Central

    Tahiri, Youssef; Taylor, Jesse

    2014-01-01

    Le Fort II and III distraction osteogenesis (DO) is a powerful tool in the craniofacial armamentarium that is most often employed to treat patients with craniofacial syndromes such as Crouzon, Apert, or Pfeiffer syndrome who present with midfacial retrusion, shallow orbits, exorbitism, malocclusion, obstructive sleep apnea and facial imbalance. In this article, the authors will provide the reader with an update on techniques for the treatment of various forms of midfacial retrusion. PMID:25383053

  1. Development of the Potassium-Argon Laser Experiment (KArLE) Instrument for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.; Li, Z.-H.; Miller, J. S.; Brinckerhoff, W. B.; Clegg, S. M.; Mahaffy, P. R.; Swindle, T. D.; Wiens, R. C.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Traditionally, geochronology has only been accomplishable on samples from dedicated sample return missions or meteorites. The capability for in situ geochronology is highly desired, because it will allow one-way planetary missions to perform dating of large numbers of samples. The success of an in situ geochronology package will not only yield data on absolute ages, but can also complement sample return missions by identifying the most interesting rocks to cache and/or return to Earth. In situ dating instruments have been proposed, but none have yet reached TRL 6 because the required high-resolution isotopic measurements are very challenging. Our team is now addressing this challenge by developing the Potassium (K) - Argon Laser Experiment (KArLE) under the NASA Planetary Instrument Definition and Development Program (PIDDP), building on previous work to develop a K-Ar in situ instrument [1]. KArLE uses a combination of several flight-proven components that enable accurate K-Ar isochron dating of planetary rocks. KArLE will ablate a rock sample, determine the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by the volume of the ablated pit using an optical method such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to +/-100 Myr, sufficient to address a wide range of geochronology problems in planetary science.

  2. Poles of integrále tritronquée and anharmonic oscillators. A WKB approach

    NASA Astrophysics Data System (ADS)

    Masoero, Davide

    2010-03-01

    Poles of solutions to the Painlevé-I equations are intimately related to the theory of the cubic anharmonic oscillator. In particular, poles of integrále tritronquée are in bijection with cubic oscillators that admit the simultaneous solutions of two quantization conditions. We analyze this pair of quantization conditions by means of a suitable version of the complex WKB method. Ai miei zii Ivan e Silvia.

  3. Contemporary genetic structure, phylogeography and past demographic processes of wild boar Sus scrofa population in Central and Eastern Europe.

    PubMed

    Kusza, Szilvia; Podgórski, Tomasz; Scandura, Massimo; Borowik, Tomasz; Jávor, András; Sidorovich, Vadim E; Bunevich, Aleksei N; Kolesnikov, Mikhail; Jędrzejewska, Bogumiła

    2014-01-01

    The wild boar (Sus scrofa) is one of the most widely distributed mammals in Europe. Its demography was affected by various events in the past and today populations are increasing throughout Europe. We examined genetic diversity, structure and population dynamics of wild boar in Central and Eastern Europe. MtDNA control region (664 bp) was sequenced in 254 wild boar from six countries (Poland, Hungary, Belarus, Ukraine, Moldova and the European part of Russia). We detected 16 haplotypes, all known from previous studies in Europe; 14 of them belonged to European 1 (E1) clade, including 13 haplotypes from E1-C and one from E1-A lineages. Two haplotypes belonged respectively to the East Asian and the Near Eastern clade. Both haplotypes were found in Russia and most probably originated from the documented translocations of wild boar. The studied populations showed moderate haplotype (0.714±0.023) and low nucleotide diversity (0.003±0.002). SAMOVA grouped the genetic structuring of Central and Eastern European wild boar into three subpopulations, comprising of: (1) north-eastern Belarus and the European part of Russia, (2) Poland, Ukraine, Moldova and most of Belarus, and (3) Hungary. The multimodal mismatch distribution, Fu's Fs index, Bayesian skyline plot and the high occurrence of shared haplotypes among populations did not suggest strong demographic fluctuations in wild boar numbers in the Holocene and pre-Holocene times. This study showed relatively weak genetic diversity and structure in Central and Eastern European wild boar populations and underlined gaps in our knowledge on the role of southern refugia and demographic processes shaping genetic diversity of wild boar in this part of Europe.

  4. Two agricultural production data libraries for risk assessment models. [Ovis aries; Capra hircus; Sus scrofa; Gallus domesticus; Meleagris gallopavo

    SciTech Connect

    Baes, C.F. III; Shor, R.W.; Sharp, R.D.; Sjoreen, A.L.

    1985-01-01

    Two data libraries based on the 1974 US Census of Agriculture are described. The data packages (AGDATC and AGDATG) are available from the Radiation Shielding Information Center (RSIC), Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831. Agricultural production and land-use information by county (AGDATC) or by 1/2 by 1/2 degree longitude-latitude grid cell (AGDATG) provide geographical resolution of the data. The libraries were designed for use in risk assessment models that simulate the transport of radionuclides from sources of airborne release through food chains to man. However, they are also suitable for use in the assessment of other airborne pollutants that can affect man from a food ingestion pathway such as effluents from synfuels or coal-fired power plants. The principal significance of the data libraries is that they provide default location-specific food-chain transport parameters when site-specific information are unavailable. Plant food categories in the data libraries include leafy vegetables, vegetables and fruits exposed to direct deposition of airborne pollutants, vegetables and fruits protected from direct deposition, and grains. Livestock feeds are also tabulated in four categories: pasture, grain, hay, and silage. Pasture was estimated by a material balance of cattle and sheep inventories, forage feed requirements, and reported harvested forage. Cattle (Bos spp.), sheep (Ovis aries), goat (Capra hircus), hog (Sus scrofa), chicken (Gallus domesticus), and turkey (Meleagris gallopavo) inventories or sales are also tabulated in the data libraries and can be used to provide estimates of meat, eggs, and milk production. Honey production also is given. Population, irrigation, and meteorological information are also listed.

  5. First Ecological Study of the Bawean Warty Pig (Sus blouchi), One of the Rarest Pigs on Earth.

    PubMed

    Rademaker, Mark; Meijaard, Erik; Semiadi, Gono; Blokland, Simen; Neilson, Eric W; Rode-Margono, Eva Johanna

    2016-01-01

    The Bawean warty pig (Sus blouchi) is an endemic pig species confined to the 192 km(2) large island of Bawean in the Java Sea, Indonesia. Due to a lack of quantitative ecological research, understanding of natural history and conservation requirements have so far been based solely on anecdotal information from interviews with local people and study of captive and museum specimens. In this study we provide the first assessment of population and habitat preferences for S. blouchi by using camera trapping. From the 4th of November 2014 to January 8th 2015, we placed camera traps at 100 locations in the forested protected areas on Bawean. In 690.31 camera days (16567.45 hours) we captured 92 independent videos showing S. blouchi. Variation in S. blouchi trapping rates with cumulative trap effort stabilized after 500 camera days. An important outcome is that, in contrast to the suggestion of previous assessments, only S. blouchi was detected and no S. scrofa was found, which excludes hybridization threats. We fitted a Random Encounter Model, which does not require the identification of individual animals, to our camera-trapping data and estimated 172-377 individuals to be present on the island. Activity patterns and habitat data indicate that S. blouchi is mainly nocturnal and prefers community forests and areas near forest borders. Next to this, we found a positive relationship between S. blouchi occupancy, distance to nearest border, litter depth and tree density in the highest ranking occupancy models. Although these relationships proved non-significant based on model averaging, their presence in the top ranking models suggests that these covariables do play a role in predicting S. blouchi occurrence on Bawean. The estimated amount of sites occupied reached 58%. Based on our results, especially the estimation of the population size and area of occupancy, we determine that the species is Endangered according to the IUCN/SSC Red List criteria.

  6. Identification and Prevalence of Globocephalus samoensis (Nematoda: Ancylostomatidae) among Wild Boars (Sus scrofa coreanus) from Southwestern Regions of Korea

    PubMed Central

    Ahn, Kyu-Sung; Ahn, Ah-Jin; Kim, Tae-Hoon; Suh, Guk-Hyun; Joo, Kyoung-Woong; Shin, Sung-Shik

    2015-01-01

    This study describes the first record of Globocephalus samoensis (Nematoda: Ancylostomatidae) recovered in wild boars from southwestern regions of Korea. Gastrointestinal tracts of 111 Korean wild boars (Sus scrofa coreanus) hunted from mountains in Suncheon-si, Gwangyang-si, and Boseong-gun between 2009 and 2012 were examined for their visceral helminths. G. samoensis, as identified by morphological characteristics of the head and tail, were recovered from the small intestine of 51 (45.9%) wild boars. Worms were found from 7 of 28 wild boars (25.0%) from Suncheon-si, 40 of 79 (50.6%) from Gwangyang-si, and all 4 (100%) from Boseong-gun. The length of adult females was 7.2±0.5 mm, and the thickest part of the body measured the average 0.47±0.03 mm, while those of males were 6.52±0.19 and 0.37±0.02 mm, respectively. The buccal cavity was equipped with a pair of large and bicuspid subventral lancets near the base of the capsule. The average length of spicules of males was 0.45±0.02 mm. By the present study, G. samoensis is recorded for the first time in southwestern regions of Korea. Additionally, morphological characteristics and identification keys provided in the present study will be helpful in the faunistic and taxonomic studies for strongylid nematodes in both domestic and wild pigs. The infection of G. samoensis apparently did not elicit pathologic lesions, as revealed by macroscopic observation during the autopsy of all wild boars in this study. PMID:26537041

  7. Mercury and selenium binding biomolecules in terrestrial mammals (Cervus elaphus and Sus scrofa) from a mercury exposed area.

    PubMed

    Ropero, M J Patiño; Fariñas, N Rodríguez; Krupp, E; Mateo, R; Nevado, J J Berzas; Martín-Doimeadios, R C Rodríguez

    2016-06-01

    Mercury (Hg) is likely bound to large biomolecules (e.g. proteins) in living organisms, and in order to assess Hg metabolic pathways and possible toxicological effects, it is essential to study these Hg containing biomolecules. However, the exact nature of most metal binding biomolecules is unknown. Such studies are still in their infancy and information on this topic is scarce because the analysis is challenging, mainly due to their lability upon digestion or extraction from the tissue. New analytical methods that allow complex Hg-biomolecules to be analysed intact are needed and only few very recent studies deal with this approach. Therefore, as an initial step towards the characterization of Hg containing biomolecules, an analytical procedure has been optimised using size-exclusion chromatography (SEC) with inductively coupled plasma mass spectrometry (ICP-MS) detection. We applied this technique to elucidate the distribution and elution profile of Hg and Se, and some physiological important elements such as Fe, Ni, Zn and Cu, to assess metal binding profiles in liver and kidney samples of red deer (Cervus elaphus) and wild boar (Sus scrofa) who roam freely within the largest Hg mining district on Earth, Almadén in Spain. Elemental fractionation profiles of the extracts from different tissues were obtained using two different SEC columns (BioSep-SEC-S2000 GL 300-1kDa and Superdex 75 10/300 GL 70-3kDa). Similar profiles of Hg were observed in red deer and wild boar; however, significant differences were evident for liver and kidney. Moreover, the profiles of Se showed a single peak at high-medium molecular weight in all investigated tissues, while co-elution of Hg with Fe, Ni, Zn and Cu was observed.

  8. Presence, viral load and characterization of Torque teno sus viruses in liver and pork chop samples at retail.

    PubMed

    Leblanc, Danielle; Houde, Alain; Gagné, Marie-Josée; Plante, Daniel; Bellon-Gagnon, Pascale; Jones, Tineke H; Muehlhauser, Victoria; Wilhelm, Barbara; Avery, Brent; Janecko, Nicol; Brassard, Julie

    2014-05-16

    Torque teno viruses (TTV) are widespread in humans, swine as well as in several other animal species. In market ready swine, the reported prevalence ranges between 11% and 100%. Through a national retail sampling plan from the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) program, 283 and 599 liver and pork chop samples, respectively, were collected over a 12-month period from commercial establishments in 5 selected geographical regions of Canada to assess the presence of Torque teno sus viruses (TTSuVs) in these products. TTSuVs were detected in 97.9% of pork chops with viral loads ranging between 1×10(4) and 9.9×10(5) genomic copies (gc)/g and 98.6% of liver samples with viral loads ranging from 1×10(5) to 9.9×10(6) gc/g. A selection of 20 positive samples (10 pork chop and 10 liver) from the 5 geographical regions were further tested for the production, of a 305bp fragment for TTSuV1 and a 253bp fragment for TTSuV2 in the non-coding region. TTSuV1 was present in all 10 liver and 10 pork chops samples while TTSuV2 was detected in 10 liver and 9 pork chop samples. Two different TTSuV1 sequences were simultaneously detected from 5 of 20 samples and 2 different TTSuV2 sequences were detected from 6 of 19 samples. The omnipresence of TTSuVs in commercial pork samples may allow its use as a viral indicator to monitor the effectiveness of cleaning and disinfecting process in slaughtering, cutting, slicing and packaging facilities.

  9. First Ecological Study of the Bawean Warty Pig (Sus blouchi), One of the Rarest Pigs on Earth

    PubMed Central

    Rademaker, Mark; Meijaard, Erik; Semiadi, Gono; Blokland, Simen; Neilson, Eric W.; Rode-Margono, Eva Johanna

    2016-01-01

    The Bawean warty pig (Sus blouchi) is an endemic pig species confined to the 192 km2 large island of Bawean in the Java Sea, Indonesia. Due to a lack of quantitative ecological research, understanding of natural history and conservation requirements have so far been based solely on anecdotal information from interviews with local people and study of captive and museum specimens. In this study we provide the first assessment of population and habitat preferences for S. blouchi by using camera trapping. From the 4th of November 2014 to January 8th 2015, we placed camera traps at 100 locations in the forested protected areas on Bawean. In 690.31 camera days (16567.45 hours) we captured 92 independent videos showing S. blouchi. Variation in S. blouchi trapping rates with cumulative trap effort stabilized after 500 camera days. An important outcome is that, in contrast to the suggestion of previous assessments, only S. blouchi was detected and no S. scrofa was found, which excludes hybridization threats. We fitted a Random Encounter Model, which does not require the identification of individual animals, to our camera-trapping data and estimated 172–377 individuals to be present on the island. Activity patterns and habitat data indicate that S. blouchi is mainly nocturnal and prefers community forests and areas near forest borders. Next to this, we found a positive relationship between S. blouchi occupancy, distance to nearest border, litter depth and tree density in the highest ranking occupancy models. Although these relationships proved non-significant based on model averaging, their presence in the top ranking models suggests that these covariables do play a role in predicting S. blouchi occurrence on Bawean. The estimated amount of sites occupied reached 58%. Based on our results, especially the estimation of the population size and area of occupancy, we determine that the species is Endangered according to the IUCN/SSC Red List criteria. PMID:27049756

  10. Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis in Eurasian wild boar (Sus scrofa scrofa).

    PubMed

    Boadella, Mariana; Lyashchenko, Konstantin; Greenwald, Reena; Esfandiari, Javan; Jaroso, Raquel; Carta, Tania; Garrido, Joseba M; Vicente, Joaquín; de la Fuente, José; Gortázar, Christian

    2011-01-01

    New tools to detect exposure of free-range Eurasian wild boar (Sus scrofa scrofa) to pathogenic mycobacteria would be valuable for improved disease surveillance and wildlife management. Two hundred sera from wild boar of known Mycobacterium bovis infection status were used to evaluate test suitability for the detection of antibodies against M. bovis and Mycobacterium avium subsp. paratuberculosis (or cross-reacting members of the M. avium complex). Two traditional enzyme-linked immunosorbent assays were evaluated using M. bovis purified protein derivative (bPPD) and paratuberculosis protoplasmatic antigen 3 (PPA3) as antigens, respectively, and a new point-of-care test format for bovine tuberculosis (bTB) that uses the innovative dual-path platform (DPP TB) test. The effect of individual factors (sex, age, lesions) on the diagnostic performance of the serologic tests was also determined. Although the DPP had a sensitivity of 89.6% and a specificity of 90.4%, for bPPD, the sensitivity was 79.2% and the specificity 100%. Both tests had a kappa agreement of 0.80. Sixty-five of 68 (95.6%) wild boar sera with antibodies against the PPA3 antigen corresponded to known M. bovis-infected wild boar. Significant differences were not observed in the bPPD and DPP readings among lesion categories or between age classes. A slight sex-related difference in sensitivity toward males in the DPP was found, but it was not detected in the bPPD enzyme-linked immunosorbent assay. The results support the use of antibody-based diagnostic tests for both large-scale and individual bTB testing of Eurasian wild boar and suggest that wild boar cannot be used as sentinels for infections caused by M. avium complex members.

  11. Long-term monitoring of 10 selected pathogens in wild boar (Sus scrofa) in Sierra Nevada National Park, southern Spain.

    PubMed

    Cano-Manuel, Francisco J; López-Olvera, Jorge; Fandos, Paulino; Soriguer, Ramón C; Pérez, Jesús M; Granados, José E

    2014-11-07

    Wild boar (Sus scrofa) populations are increasing in the Iberian Peninsula, and population management must include disease management and control. In this study, the epidemiology of 10 selected pathogens (Aujeszky's disease virus - ADV, porcine reproductive and respiratory syndrome virus - PRRSV, porcine influenza virus, porcine circovirus, porcine parvovirus, Erysipelotrix rhusiopathiae, Leptospira pomona, Chlamydia/Chlamydiaceae sp., Salmonella sp. and Mycobacterium bovis) in the wild boar population in Sierra Nevada National Park (SNNP), an open unfenced area, is reported, taking into account wild boar population abundance variation in space and time in an open unfenced environment. A total of 1103 wild boar were sampled in 141 hunting events randomly carried out for sampling in seven hunting seasons (October to February from 2002-2003 to 2009-2010 (except 2007-2008). Prevalence was overall lower than those previously reported for fenced wild boar populations in Spain, but all the pathogens analyzed except PRRSV were considered endemic in the SNNP. ADV, E. rhusiopathiae and total pathogen prevalence were positively correlated to wild boar density. Prevalence in the positive areas was significantly higher in females for ADV, E. rhusiopathiae, L. pomona, Chlamydia/Chlamydiaceae sp. and Salmonella sp., and in males for M. bovis. This longitudinal study provides the first data on the health status of the relatively unmanaged and low density wild boar population of SNNP. It is concluded that non-intensively managed wild boar populations are able to maintain the circulation of several pathogens, even in low prevalences and in open unfenced areas with natural density variation both in time and space.

  12. Identification and Prevalence of Globocephalus samoensis (Nematoda: Ancylostomatidae) among Wild Boars (Sus scrofa coreanus) from Southwestern Regions of Korea.

    PubMed

    Ahn, Kyu-Sung; Ahn, Ah-Jin; Kim, Tae-Hoon; Suh, Guk-Hyun; Joo, Kyoung-Woong; Shin, Sung-Shik

    2015-10-01

    This study describes the first record of Globocephalus samoensis (Nematoda: Ancylostomatidae) recovered in wild boars from southwestern regions of Korea. Gastrointestinal tracts of 111 Korean wild boars (Sus scrofa coreanus) hunted from mountains in Suncheon-si, Gwangyang-si, and Boseong-gun between 2009 and 2012 were examined for their visceral helminths. G. samoensis, as identified by morphological characteristics of the head and tail, were recovered from the small intestine of 51 (45.9%) wild boars. Worms were found from 7 of 28 wild boars (25.0%) from Suncheon-si, 40 of 79 (50.6%) from Gwangyang-si, and all 4 (100%) from Boseong-gun. The length of adult females was 7.2±0.5 mm, and the thickest part of the body measured the average 0.47±0.03 mm, while those of males were 6.52±0.19 and 0.37±0.02 mm, respectively. The buccal cavity was equipped with a pair of large and bicuspid subventral lancets near the base of the capsule. The average length of spicules of males was 0.45±0.02 mm. By the present study, G. samoensis is recorded for the first time in southwestern regions of Korea. Additionally, morphological characteristics and identification keys provided in the present study will be helpful in the faunistic and taxonomic studies for strongylid nematodes in both domestic and wild pigs. The infection of G. samoensis apparently did not elicit pathologic lesions, as revealed by macroscopic observation during the autopsy of all wild boars in this study.

  13. Serologic, molecular, and pathologic survey of pseudorabies virus infection in hunted wild boars (Sus scrofa) in Italy.

    PubMed

    Verin, Ranieri; Varuzza, Paolo; Mazzei, Maurizio; Poli, Alessandro

    2014-07-01

    To investigate pseudorabies-virus (PrV) -antibody and viral-DNA prevalence, we collected blood, nasal and genital swabs, and tonsillar and lymph-node tissue samples from 139 wild boars (Sus scrofa; 39 piglets, 30 juveniles, and 70 adults), during the hunting season of 2010-2011 in Tuscany, Central Italy. We performed immunohistochemistry with anti-PrV monoclonal antibodies on selected tissue samples. Forty-three of 139 (30.9%) boars were PrV-antibody positive and a 1,954-base-pair PrV-specific product was amplified from nine nasal (6.5%) and 26 genital (18.7%) swabs. Sequence analysis of PrV-positive PCR products revealed identity scores of 99-100% with Suid herpesvirus 1 strain Becker (JF797219) and confirmed the identification of PrV DNA in tested swabs. There was significantly higher antibody prevalence in adults than in juveniles and in piglets than in juveniles. The prevalence of viral DNA was significantly higher in genital swabs than in nasal specimens. The percentage of positive nasal swabs did not differ among age classes. Piglets had a higher percentage of PCR-positive genital swabs than juvenile and adult subjects (30.8% vs. 13.3% and 14.3%, respectively). Results confirmed that PrV infection is widespread in the wild boar population in the study area. The presence of anti-PrV antibodies and of the PrV virus in piglets could be related to vertical transmission of the virus. This hypothesis was also supported by a higher presence of viral genome in genital swabs than in nasal swabs. This field study supports the importance of vertical transmission of PrV, and the high prevalence of virus in genital swabs supports venereal transmission in adult feral boars.

  14. Response of pigmented porcine skin (Sus scrofa domestica) to single 3.8-micron laser radiation pulses

    NASA Astrophysics Data System (ADS)

    Bostick, Anthony C.; Johnson, Thomas E.; Randolph, Donald Q.; Winston, Golda C. H.

    2005-04-01

    Background and purpose: The purpose of this study is to determine the impact of melanin on skin response to single 3.8 micron, eight microsecond laser pulses and the difference in lesion formation thresholds for input into laser safety standards. Williams et al., performed a study examining laser tissue interaction from 3.8-micron lasers in lightly pigmented Yorkshire pigs (Sus scrofa domestica). However, studies performed by Eggleston et al comparing pigmented and lightly pigmented skin with human skin found that the Yucatan mini-pig is a superior model for laser skin exposures. Methods: Five Yucatan mini-pigs under general anesthesia were exposed to 3.8 micron laser pulses ranging from 0.8 J/cm2 to 93 J/cm2. Gross examinations were done acutely and 24 hours after laser exposure. Skin biopsies were then collected at various times post exposure, and histologic examinations were conducted. Results: The 24 hour ED50 was determined to be 4.5 J/cm2 with fiducial limits of 6.2 and 2.2 J/cm2. As deposited energy was increased, the lesion presentation ranged from whitening of the epidermis (4 J/cm2) to whitening with inflammatory centers (14 J/cm2), and at the highest energy levels inflammatory areas were replaced with an epidermal ulcerated central area (>21 J/cm2). Conclusion: Preliminary findings suggest pigmentation or melanin may play a minor role in the mechanism of laser-tissue damage. The ED50 of Yorkshire pigs was 2.6 J/cm2. The ED50 of the Yucatan mini-pig was found to be 3.6 J/cm2, and although it was higher, it is still within the 95% fiducial limits.

  15. Molecular investigation for bacterial and protozoan tick-borne pathogens in wild boars (Sus scrofa) from southern Germany.

    PubMed

    Silaghi, Cornelia; Pfister, Kurt; Overzier, Evelyn

    2014-05-01

    Wild boars (Sus scrofa) have been suggested to be involved in the enzootic cycle of the tick-borne pathogen Anaplasma phagocytophilum. This observation raises the question whether they serve as reservoir hosts for A. phagocytophilum and potentially for other tick-borne pathogens of public health relevance. The aim of this study was to investigate wild boars and their ticks from a forest site in southern Germany for the presence of A. phagocytophilum, Candidatus Neoehrlichia mikurensis, Rickettsia spp., Borrelia burgdorferi sensu lato (s.l.), Borrelia spp. of the relapsing fever group, and Babesia spp. Therefore, 24 wild boars collected from October, 2010, to February, 2013, were investigated by molecular methods. DNA of A. phagocytophilum was detected in three out of 24 (12.5%) wild boars and in four out of 16 (25%) ticks. DNA of none of the other pathogens was found in any wild boar, but Rickettsia spp., B. burgdorferi s.l., and Cand. N. mikurensis were found in one of the investigated ticks each. Sequences of the partial 16S rRNA gene of A. phagocytophilum from one spleen and two ticks showed 100% similarity to GenBank entries from human anaplasmosis cases (accession nos. U02521 and AY886761). The sequence from the third tick was 100% similar to sequences obtained from Ixodes ricinus and roe deer from the same study area previously. Detecting a potentially human pathogenic A. phagocytophilum variant in wild boar confirms previous findings and is of public health interest. To our knowledge, this is the first report of A. phagocytophilum in wild boars in Germany. Whether wild boars support the enzootic cycle of A. phagocytophilum variants involved in human disease requires further attention in future systematic studies.

  16. Une formation à la recherche en médecine transfusionnelle dans le monde francophone

    PubMed Central

    Shiboski, C.; Fontanet, A.; Murphy, E.L.

    2010-01-01

    Un enseignement accéléré et francophone de formation à la recherche en médecine transfusionnelle a été récemment instauré à l’Institut Pasteur de Paris, sous la codirection de membres hospitalo-universitaires de l’université de Californie San Francisco (UCSF), du Blood Systems Research Institute (BSRI) et de l’Institut national de la transfusion sanguine (INTS). Le but est de former des professionnels de la transfusion des pays en voie de développement à mener une activité de recherche dont les résultats peuvent contribuer à un renforcement de la qualité des soins transfusionnels et de la sécurité transfusionnelle dans leur pays. Le cours enseigne les méthodes de recherche clinique et épidémiologique, et leurs applications transfusionnelles potentielles. Chaque étudiant élabore au cours du stage un protocole personnel de recherche, qu’il lui sera loisible de mettre ensuite en pratique dans le centre de transfusion ou l’hôpital où il exerce. PMID:19640755

  17. Le schwannome pénien: à propos d'un cas

    PubMed Central

    Essatara, Younes; Benazzouz, Mohammed Hicham; Sami, Rekik; Bondil, Pierre

    2014-01-01

    Le Schwannome, ou neurinome, du pénis est une tumeur extrêmement rare. Il s'agit d'une tumeur de la gaine des nerfs péniens. Un homme de 29 ans opéré pour un neurinome du pénis. La tumeur fut réséquée avec succès tout en préservant la fonction érectile du patient. La résection tumorale est le traitement de choix dans les schwannomes localisés, un suivi régulier est conseillé. Le taux de récidive locale est extrêmement faible après résection complète. A travers cet article, nous allons présenter un nouveau cas de neurinome du pénis et nous allons faire une brève revue de la littérature sur cette pathologie rare. PMID:25368711

  18. Contrôle d'une machine asynchrone par estimation robuste de la vitesse

    NASA Astrophysics Data System (ADS)

    Roboam, X.; Hapiot, J. C.; de Fornel, B.; Andrieux, C.

    1992-03-01

    This paper describes the study and the implementation of a variable speed drive for induction motor with no mechanical sensor. Power is supplied by a current-controlled voltage-source inverter. The lack of information (only two line-current sensors) requires an accurate and reliable reconstitution of the main quantities not sensed (flux, speed, torque). The results obtained show the excellent quality of the estimated speed, whatever the operating condition and despite the perturbations applied to the system. This study finally leads to the construction of a prototype. Cet article décrit l'étude et la mise en oeuvre d'un variateur de vitesse pour machine asynchrone sans capteur mécanique et alimentée par un onduleur de tension cotrôlé en courant. Le manque d'information (2 capteurs de courants de ligne uniquement) nécessite la reconstitution fiable et précise des grandeurs fondamentales non mesurées (flux, vitesse, couple). Les résultats obtenus montrent notamment l'excellente qualité de l'estimation de vitesse, quel que soit le point de fonctionnement et en dépit des perturbations auxquelles le système est soumis. Cette étude donne lieu à la réalisation d'un variateur prototype.

  19. The Adverse Effects of Le Châtelier's Principle on Teacher Understanding of Chemical Equilibrium

    NASA Astrophysics Data System (ADS)

    Cheung, Derek

    2009-04-01

    Although the scientific inadequacy of Le Châtelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has neglected teacher misconceptions. This study aimed to determine how Le Châtelier's principle adversely affects teachers' ability to solve chemical equilibrium problems. This area of research is critically important because teachers cannot help their students understand what they themselves do not understand. In this study, a misconception test was developed and administered to a sample of 33 secondary chemistry teachers in Hong Kong. The test consisted of three open-ended chemical equilibrium questions. Analysis of teacher responses revealed that most of the 33 teachers failed the test as they relied on Le Châtelier's principle rather than the equilibrium law to tackle the three chemical equilibrium problems. Teachers' misconceptions about chemical equilibrium were categorized. Implications of these findings for chemistry teacher education and selection of curriculum content for school chemistry are discussed.

  20. Students' and teachers' misapplication of le chatelier's principle: Implications for the teaching of chemical equilibrium

    NASA Astrophysics Data System (ADS)

    Quílez-Pardo, Juan; Solaz-Portolés, Joan Josep

    The aim of this article was to study the reasons, strategies, and procedures that both students and teachers use to solve some chemical equilibrium questions and problems. Inappropriate conceptions on teaching and a lack of knowledge regarding the limited usefulness of Le Chatelier's principle, with its vague and ambiguous formulation and textbook presentation, may be some of the sources of misconceptions about the prediction of the effect of changing conditions on chemical equilibrium. To diagnose misconceptions and their possible sources, a written test was developed and administered to 170 1st-year university chemistry students. A chemical equilibrium problem, relating to the students' test, was solved by 40 chemistry teachers. First, we ascertained that teacher's conceptions might influence the problem-solving strategies of the learner. Based on this first aspect, our discussion also concerns students' and teachers' misconceptions related to the Le Chatelier's principle. Misconceptions emerged through: (a) misapplication and misunderstanding of Le Chatelier's principle; (b) use of rote-learning recall and algorithmic procedures; (c) incorrect control of the variables involved; (d) limited use of the chemical equilibrium law; (e) a lack of mastery of chemical equilibrium principles and difficulty in transferring such principles to new situations. To avoid chemical equilibrium misconceptions, a specific pattern of conceptual and methodological change may be considered.Received: 16 November 1993; Revised: 21 September 1994;

  1. Cultural Heritage Protection Issues In Leśnica, The Settlement Of Wrocław

    NASA Astrophysics Data System (ADS)

    Kononowicz, Alena

    2015-09-01

    Leśnica, today the settlement on the western edge of Wrocław, formerly was an independent town, located on a previously wooded area, with a linear street system. It developed in the Middle Ages around the castle and church playing a service role for the Silesian Piast court on their way to Legnica and during hunting. In the thirteenth century it received city rights, and lost them in the eighteenth century. After the Piast dynasty had died out, it was sold by John of Luxembourg, and repeatedly changed its owners. In the nineteenth century it developed thanks to the industry, tourism and a convenient railway connection to Wrocław as well as hotel and restaurant facilities. In 1928, Leśnica was incorporated into Wrocław. After the Second World War, it lost its cultural continuity. In the 1970's, middle-heigh and high prefabricated buildings were built in the vicinity of a residential district. At the end of the twentieth and early twenty-first century, local industries were liquidated, and intensive land development started, causing the systematic blurring of its small-town character and its urban space started to acquire a character of a big city. In 2004, the old part of Leśnica was entered in the Register of Monuments. Also a ring road was planned, moving the cumbersome and dangerous transit traffic away from historic Średzka Street beyond the southern border of the settlement.

  2. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    NASA Astrophysics Data System (ADS)

    Maloney, Thomas M.; Prokopius, Paul R.; Voecks, Gerald E.

    1995-01-01

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbed fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway.

  3. Three-dimensional position changes of the midface following Le Fort III advancement in syndromic craniosynostosis.

    PubMed

    Bouw, Frederik P; Nout, Erik; van Bezooijen, Jine S; Koudstaal, Maarten J; Veenland, Jifke F; Wolvius, Eppo B

    2015-07-01

    Little is known about the positional change of the Le Fort III segment following advancement. To study this, pre- and postoperative computed tomography scans of 18 craniosynosthosis patients were analyzed. The Le Fort III segment movement was measured by creating a reference coordinate system and by superpositioning the postoperative over the preoperative scan. On both the pre- and postoperative scans, four anatomical landmarks were marked: the most anterior point of the left and right foramen infraorbitale, the nasion, and the anterior nasal spine. A significant anterior movement of the four reference points was observed. No significant transversal differences were found. A significant difference between the anterior movement of the nasion and anterior nasal spine was found. In vertical dimension, there was a significant cranial movement of nasion in the study group. In addition, from all patients standardized lateral X-rays were viewed to determine the location and direction of force application that were linked to the outcomes of the three-dimensional movement of the nasion and anterior nasal spine (ANS) and the surgical technique. Conclusively, a significant advancement of the midface can be achieved with Le Fort III distraction osteogenesis in this specific patient group. Counterclockwise movement seemed to be the most dominant movement despite different modes of anchorage.

  4. Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2E

    PubMed Central

    Dale, Jeffrey M.; Villalon, Eric; Shannon, Stephen G.; Barry, Devin M.; Markey, Rachel M.; Garcia, Virginia B.; Garcia, Michael L.

    2012-01-01

    Charcot-Marie-Tooth disease (CMT) is the most commonly inherited peripheral neuropathy. CMT disease signs include distal limb neuropathy, abnormal gaiting, exacerbation of neuropathy, sensory defects, and deafness. We generated a novel line of CMT2E mice expressing a hNF-LE397K transgene, which displayed muscle atrophy of the lower limbs without denervation, proximal reduction in large caliber axons, and decreased nerve conduction velocity. In this study, we demonstrated that hNF-LE397K mice developed abnormal gait of the hind limbs. The identification of severe gaiting defects in combination with previously observed muscle atrophy, reduced axon caliber, and decreased nerve conduction velocity suggests that hNF-LE397K mice recapitulate many of clinical signs associated with CMT2E. Therefore, hNF-LE397K mice provide a context for potential therapeutic intervention. PMID:22288874

  5. Modelisation microstructurale en fatigue/fluage a froid des alliages de titane quasi alpha par le modele des automates cellulaires

    NASA Astrophysics Data System (ADS)

    Boutana, Mohammed Nabil

    Les proprietes d'emploi des alliages de titane sont extremement dependantes a certains aspects des microstructures developpees lors de leur elaboration. Ces microstructures peuvent etre fortement heterogenes du point de vue de leur orientation cristallographique et de leur repartition spatiale. Leurs influences sur le comportement du materiau et son endommagement precoce sont des questions qui sont actuellement soulevees. Dans le present projet de doctorat on chercher a repondre a cette question mais aussi de presenter des solutions tangibles quant a l'utilisation securitaire de ces alliages. Un nouveau modele appele automate cellulaire a ete developpe pour simuler le comportement mecanique des alliages de titane en fatigue-fluage a froid. Ces modeles ont permet de mieux comprendre la correlation entre la microstructure et le comportement mecanique du materiau et surtout une analyse detaillee du comportement local du materiau. Mots-cles: Automate cellulaire, fatigue/fluage, alliage de titane, inclusion d'Eshelby, modelisation

  6. Crystallization and preliminary X-ray crystallographic analysis of the extracellular domain of LePRK2 from Lycopersicon esculentum.

    PubMed

    Xu, Anbi; Huang, Laiqiang

    2014-02-01

    The tomato (Lycopersicon esculentum) pollen-specific receptor kinase 2 (LePRK2) is a member of the large receptor-like kinase (RLK) family and is expressed specifically in mature pollen and pollen tubes in L. esculentum. Like other RLKs, LePRK2 contains a characteristic N-terminal leucine-rich repeat (LRR) extracellular domain, the primary function of which is in protein-protein interactions. The LePRK2 LRR is likely to bind candidate ligands from the external environment, leading to a signal transduction cascade required for successful pollination. LePRK2-LRR was purified using an insect-cell secretion expression system and was crystallized using the vapour-diffusion method. The crystals diffracted to a resolution of 2.50 Å and belonged to space group I4(1)22, with unit-cell parameters a = b = 93.94, c = 134.44 Å and one molecule per asymmetric unit.

  7. Overexpression of the Tomato Pollen Receptor Kinase LePRK1 Rewires Pollen Tube Growth to a Blebbing Mode[W][OPEN

    PubMed Central

    Gui, Cai-Ping; Dong, Xin; Liu, Hai-Kuan; Huang, Wei-Jie; Zhang, Dong; Wang, Shu-Jie; Barberini, María Laura; Gao, Xiao-Yan; Muschietti, Jorge; McCormick, Sheila

    2014-01-01

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP), a Rop guanine nucleotide exchange factor. Here, we show that pollen tubes overexpressing LePRK1 or a truncated LePRK1 lacking its extracellular domain (LePRK1ΔECD) have enlarged tips but also extend their leading edges by producing “blebs.” Coexpression of LePRK1 and tomato PLIM2a, an actin bundling protein that interacts with KPP in a Ca2+-responsive manner, suppressed these LePRK1 overexpression phenotypes, whereas pollen tubes coexpressing KPP, LePRK1, and PLIM2a resumed the blebbing growth mode. We conclude that overexpression of LePRK1 or LePRK1ΔECD rewires pollen tube growth to a blebbing mode, through KPP- and PLIM2a-mediated bundling of actin filaments from tip plasma membranes. Arabidopsis thaliana pollen tubes expressing LePRK1ΔECD also grew by blebbing. Our results exposed a hidden capability of the pollen tube cell: upon overexpression of a single membrane-localized molecule, LePRK1 or LePRK1ΔECD, it can switch to an alternative mechanism for extension of the leading edge that is analogous to the blebbing growth mode reported for Dictyostelium and for Drosophila melanogaster stem cells. PMID:25194029

  8. Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein.

    PubMed Central

    Harry, J B; Wettstein, F O

    1996-01-01

    Cottontail rabbit papillomavirus induces on cottontail and domestic rabbits papillomas which progress at a high frequency to carcinoma. The virus encodes three transforming proteins; one is translated from open reading frame (ORF) E7 and binds the retinoblastoma protein, and two, LE6 and SE6, are translated from the first and second ATGs of ORF E6, respectively. Here we show that neither of the E6 proteins coprecipitated with p53 in vitro, nor did they bind to a recently identified E6-binding protein (J. J. Chen, C. E. Reid, V. Band, and E. Androphy, Science 269:529-531, 1995). This protein was shown to bind to the E6 proteins of the high-risk human papillomairus types 16 and 18 but not to the low-risk human papillomavirus types VI and II. In-frame deletions cloned into the pZipNeo vector were used to identify structural features of SE6 and LE6 important for transformation of NIH 3T3 cells. Three deletions covering the amino-terminal half of SE6 did not transform cells. In two of the three deletions, two Cys-X-X-Cys motifs were deleted, each deletion preventing the formation of one of the potential small Zn fingers of SE6. Among the LE6 deletions, only one had a reduced transformation efficiency, while seven transformed cells at least as efficiently as wild-type LE6. In each of three of these seven mutants, two Cys-X-X-Cys motifs were deleted. None of the three amino acid deletions which abolished transformation by SE6 reduced transformation by LE6. Furthermore, transformation did not correlate with the level of SE6 or LE6 proteins detectable. ORF E8 colinear with ORF E6, which could generate a 50-amino-acid protein with a hydrophobic segment, did not transform cells when cloned into the pZipNeo vector. However, mutation of the E8 ATG, which did not alter the amino acid sequence of LE6, increased transformation by LE6 without affecting the level of LE6 expression. The data suggest that transformation by the E6 proteins is not mediated by interfering with p53

  9. Profil évolutif et pronostic des tumeurs urothéliales de la vessie chez le sujet jeune

    PubMed Central

    Bouzouita, Abderrazak; Saadi, Ahmed; Kerkeni, Walid; Chakroun, Marouene; Cherif, Mohamed; Ayed, Haroun; Selmi, Selim; Derouiche, Amine; Benslama, Riadh Mohamed; Chebil, Mohamed

    2016-01-01

    Résumé But: Les tumeurs urothéliales de la vessie sont rares chez le jeune adulte. Leur profil évolutif et leur pronostic restent matière à contro-verse. Nous rapportons notre expérience à propos de 54 patients. Méthodologie: Entre 1990 et 2010, 54 patients de moins de 40 ans au moment du diagnostic ont été traités pour carcinome à cellules transitionnelles de la vessie. Nous avons étudié le profil évolutif de ces tumeurs en séparant les patients en deux groupes (moins de 30 ans, et 30 à 40 ans). Résultats: La tumeur n’infiltrait pas le muscle vésical dans 37 cas et l’infiltrait dans 17 cas. Pour les tumeurs n’infiltrant pas le muscle vésical, elles étaient de stade Ta dans 20 cas et de grade I–II dans 36 cas. Le pronostic de ces tumeurs était meilleur avant l’âge de 30 ans avec un taux de récidive de 15,3 % sans progression. Pour les patients de 30 à 40 ans, le taux de récidive était de 33,3 %, et 25 % des tumeurs qui ont récidivé ont présenté une progression du stade. Pour les tumeurs infiltrant le muscle vésical, le pronostic était sombre (localement avancées dans neuf cas et métastatiques d’emblée dans cinq cas). Conclusion: Le profil évolutif des tumeurs n’infiltrant pas le muscle vésical a semblé meilleur avant l’âge de 30 ans. Entre 30 et 40 ans, le profil évolutif s’est approché de celui des sujets âgés. Les tumeurs infiltrantes étaient souvent évoluées et agressives, évoquant un potentiel évolutif particulier. PMID:27330577

  10. The role of anti-LeY antibody in the downregulation of MAPKs/COX-2 pathway in gastric cancer.

    PubMed

    Aziz, Faisal; Qiu, Yan

    2014-04-01

    Monoclonal antibody-based treatments of cancer which serve as magic 'bullets' have been established as one of the most successful therapeutic strategies. A variety of antigens has been investigated as targets for the mAb therapy of gastric cancer, including the carbohydrate type 2 blood group antigen. Lewis Y (LeY) is overexpressed on tumor cells surface either as glycoproteins or glycolipids. LeY is difucosylated oligosaccharide with the chemical structure [Fucα1,2Galβ1→4(Fucα1,3)GlcNAcβ1→R], which is catalyzed by fucosyltransferases, such as FUT1 (α1,2) and FUT4 (α1,3). The role of LeY antigen in cancer treatment and prevention has been extensively studied. Moreover, the cyclooxygenase- 2 (COX-2) is an early event protein, highly expressed in H. pylori-related gastric cancer. COX-2 may play a pivotal part in the maintenance of tumor viability, growth, and metastasis. The COX-2 is upregulated in a variety of cancers, including gastric cancer. However, its inhibition may prevent or reverse gastric carcinogenesis. H. pylori mediated alteration of COX-2 through MAPKs pathway is one of the mechanisms that is implicated in gastric cancer. We have found COX-2 and LeY to be correlative sources of specific gastric biomarkers in gastric cancer, which is upregulated in the gastric cancer through MAPKs pathway. In addition, the anti-LeY antibody significantly downregulated the COX-2 expression through MAPKs pathway, helpful to the treatment of gastric cancer. In this review, we summarize the therapeutic effect of anti-LeY antibody, including the crucial role of COX-2 and LeY antigen in gastric cancer and discuss the COX-2 inhibition by anti-LeY antibody through MAPKs pathway.

  11. Troubles psychotiques précipités par le mariage : étude de trois observations

    PubMed Central

    Jaweher, Masmoudi; Kammoun, Mohamed Faouzi; Inès, Feki; Imen, Baati; Rim, Sallami; Abdelaziz, Jaoua

    2013-01-01

    Le mariage est un évènement très investi dans notre culture arabo-musulmane. Il présente une situation à grande charge émotionnelle et ayant un vécu stressant. C'est ainsi qu'il peut être à l'origine de la décompensation de certains troubles psychiatriques. Ce moment particulier de déclenchement de la pathologie peut altérer significativement l'adaptation familiale et sociale du patient en question, le rendant dépendant en partie ou en totalité à une institution. Dans ce travail, nous proposons d’étudier certains facteurs psychiques, sociaux et culturels pouvant aboutir à la précipitation des manifestations psychotiques par le mariage. Il s'agit de l’étude de trois observations cliniques, deux hommes et une femme, hospitalisés dans le service de psychiatrie A du CHU Hédi Chaker de Sfax et qui ont développés des manifestations psychotiques de façon concomitante à leur mariage. La durée moyenne de survenue des crises a été de vingt ans, le diagnostic retenu a été celui de trouble bipolaire dans deux cas et d'une schizophrénie indifférenciée chez le troisième patient. L’évolution s'est faite vers une chronicisation de deux malades et une dépendance institutionnelle dans le troisième cas. La précipitation des troubles psychotiques par le mariage, reste un phénomène en relation intime avec les composantes culturelles, elles-mêmes sont déterminantes dans la prise en charge ultérieure de ces patients. PMID:23785551

  12. Genetic resistance in experimental autoimmune encephalomyelitis. I. Analysis of the mechanism of LeR resistance using radiation chimeras

    SciTech Connect

    Pelfrey, C.M.; Waxman, F.J.; Whitacre, C.C. )

    1989-09-01

    Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease of the central nervous system that has been extensively studied in the rat. The Lewis rat is highly susceptible to the induction of EAE, while the Lewis resistant (LeR) rat is known to be resistant. In this paper, we demonstrate that the LeR rat, which was derived from the Lewis strain by inbreeding of fully resistant animals, is histocompatible with the Lewis strain. Radiation chimeras, a tool for distinguishing between immunologic and nonimmunologic resistance mechanisms, were utilized to analyze the cellular mechanisms involved in genetic resistance to EAE. By transplanting bone marrow cells from LeR rats into irradiated Lewis recipients, Lewis rats were rendered resistant to EAE induction. Likewise, transplanting Lewis bone marrow cells into irradiated LeR recipients rendered LeR rats susceptible. Mixed lymphoid cell chimeras using bone marrow, spleen, and thymus cells in Lewis recipient rats revealed individual lymphoid cell types and cell interactions that significantly affected the incidence and severity of EAE. Our results suggest that LeR resistance is mediated by hematopoietic/immune cells, and that cells located in the spleen appear to play a critical role in the resistance/susceptibility to EAE induction. Depletion of splenic adherent cells did not change the patterns of EAE resistance. In vivo cell mixing studies suggested the presence of a suppressor cell population in the LeR spleen preparations which exerted an inhibitory effect on Lewis autoimmune responses. Thus, the mechanism of LeR resistance appears to be different from that in other EAE-resistant animals.

  13. Considérations nosographiques sur le délire d'infestation parasitaire à travers trois observations cliniques

    PubMed Central

    Berhili, Nabil; Bout, Amine; Hlal, Hayat; Aarab, Chadya; Aalouane, Rachid; Rammouz, Ismail

    2016-01-01

    Le syndrome d'Ekbom, ou délire d'infestation parasitaire, est une pathologie rare, caractérisée par la conviction inébranlable d'avoir une peau infestée d'insectes ou de parasites. Il s'agit d'un délire monothématique à mécanisme hallucinatoire qui touche typiquement les femmes d’âge avancé. Nous rapportons les cas de trois patients qui présentent un délire d'infestation parasitaire dans des contextes cliniques différents. Le premier patient souffre d'un délire d'infestation isolé correspondant à la forme décrite par Karl Ekbom. Le deuxième cas présente un délire d'infestation secondaire, s'inscrivant dans le cadre d'une leuco-encéphalopathie de type CADASIL. Enfin, le troisième patient se présente dans un tableau évocateur d'un épisode dépressif avec une caractéristique psychotique qui intègre le délire d'infestation. Ces trois vignettes cliniques illustrent parfaitement le caractère trans-nosographique de ce syndrome ainsi que les difficultés de prise en charge de ces patients, tant au niveau de l'alliance thérapeutique que sur le plan des choix en matière de traitement pharmacologiques. PMID:27642468

  14. Recherche d'une nouvelle configuration de bobines supraconductrices pour le stockage d'énergie

    NASA Astrophysics Data System (ADS)

    Takorabet, M.; Mailfert, A.; Colteu, A.

    1998-04-01

    Energy storage using superconducting coils involves the problem of electromagnetic field pollution outside the considered system. Different configurations are widely studied: the torus, the alone solenoid and multiple parallel solenoids enclosed in one container. A new configuration which minimizes the external pollution is studied in this paper. The theoretical system is composed of two spherical distributions of the current which are concentric. The analytical study uses solution of Laplace equations. Parametric study covers energy, flux density and geometrical data. The second study concerns the numerical approach of this design using coaxial solenoids. A comparison between this new system and the known systems is presented as a conclusion. Le stockage d'énergie à l'aide de bobines supraconductrices soulève généralement le problème de la pollution électromagnétique par des champs de fuite extérieurs au dispositif. Différentes configurations ont été classiquement étudiées : le solénoïde, le tore, ainsi que les solénoïdes à axes parallèles non concentriques bobinés tête-bêche, en "fagot". Nous étudions ici une nouvelle configuration de stockage qui n'engendre qu'une pollution extérieure minimale. Le système théorique de base est constitué par l'association de deux distributions sphériques de courant concentriques. L'étude analytique que nous présentons s'appuie sur la résolution de l'équation de Laplace. L'étude de ce système couvre les données suivantes : l'énergie, l'induction ainsi que les données géométriques. On étudie aussi une configuration approchée de la configuration sphérique, constituée par des bobines circulaires. Une comparaison de ce système avec les solutions connues sera apportée en conclusion.

  15. Le syndrome du canal carpien chez les patients hémodialysés chroniques

    PubMed Central

    Mbarki, Houda; Akrichi, Amine; Lazrak, Amine; Maaroufi, Chakib; Midaoui, Aouatif El; Tachfouti, Nabil; Jellouli, Wafa; Arrayhani, Mohamed; Belahsen, Mohamed Faouzi; Sqalli, Tarik

    2013-01-01

    Le syndrome du canal carpien (SCC) regroupe l'ensemble des signes et symptômes liés à la compression du nerf médian dans le canal carpien. Cette manifestation de l'amylose à béta2-microglobuline est une complication fréquente de l'hémodialyse au long cours. L'objectif de ce travail est d'analyser les caractéristiques du SCC et de déterminer les facteurs liés à sa survenue chez les hémodialysés chroniques. Nous rapportons une étude transversale monocentrique, menée au 3ème trimestre de l'année 2009, portant sur les patients adultes hémodialysés chroniques au service de Néphrologie-Hémodialyse au CHU de Fès. 59 patients ont accepté de participer à l'étude. Leurs âge moyen est de 48 ± 15 ans avec un sex-ratio de 0,9. Ils bénéficient tous de l'hémodialyse intermittente à raison de 10 à 12 heures par semaine, par une membrane de dialyse en polysulfone à basse perméabilité. La durée moyenne en hémodialyse est de 83 ± 6,5 mois. La prévalence du SCC dans notre centre est de 30,5%. L'électromyogramme (EMG) a confirmé la suspicion clinique du SCC chez 11 patients et a diagnostiqué un SCC chez 8 patients asymptomatiques. La comparaison statistique entre les deux groupes de patients avec et sans SCC a démontré que la survenue de ce syndrome est liée à: l'âge actuel, l'âge avancé à la mise en hémodialyse, le sexe féminin, l'excès pondéral, et l'abord vasculaire. Le SCC est une complication fréquente de l'hémodialyse chronique. L'amélioration de la qualité de dialyse permettrait de réduire le risque de survenue du SCC. PMID:23504584

  16. Le cancer en Mauritanie : résultats sur 10 ans du registre hospitalier de Nouakchott

    PubMed Central

    Baba, Nacer Dine Ould Mohamed; Sauvaget, Catherine

    2013-01-01

    Le fardeau du cancer reste mal connu en Mauritanie. Il n'est basé que sur des extrapolations de l'incidence des cancers des pays avoisinants. Les données du registre de l'hôpital national permettent de décrire les cas avec un diagnostic histologique. Tous les cas de cancers enregistrés par le service d'anatomo-pathologie de l'hôpital national de Nouakchott de 2000 à 2009 ont été analysés. En 10 ans, 3305 prélèvements histologiques ont été analysés (hommes:42%, femmes:58%). Chez l'homme, le cancer le plus fréquemment analysé était le cancer de la peau (218 cas au total, 189 cas en excluant mélanome), suivi de la prostate (203), des cancers digestifs (179, colorectal et ‘sophage), et des lymphomes (151). Chez la femme, un quart des biopsies était des cancers du sein (485), suivi du col utérin (344), de la sphère gynécologique (218, ovaire et corps utérin), et de la peau (114). Les cancers du foie, du poumon ou de la vessie étaient peu fréquents. Ces résultats ne reflètent pas l'incidence ni l'actuel fardeau du cancer en Mauritanie puisque de nombreux patients diagnostiqués avec un cancer ne reçoivent pas d'examen anatomopathologique. Si, comme dans les pays avoisinants du Maroc et du Mali, les cancers du col et du sein sont les pathologies les plus fréquentes chez la femme, la distribution des cancers chez l'homme dans ce registre hospitalier diffère des résultats des registres de population du Maroc et du Mali où les cancers du poumon, du foie, de la prostate et de la vessie dominent. PMID:23785554

  17. le hydatiforme partielle invasive et métastatique: à propos d'un cas

    PubMed Central

    Lazrak, Ikram; Ihssane, Hakimi; Babahabib, Moulay Abdellah; Kouach, Jaouad; El Ochi, Mohamed Reda; Moussaoui, Moulay Driss; Dehayni, Mohamed

    2014-01-01

    Depuis plusieurs années, la môle hydatiforme partielle(MHP) a été considérée comme une entité bénigne qui ne nécessite pas une surveillance stricte comme celle de la môle complète(MC), mais l'apparition de quelques cas sporadiques de transformation de la môle partielle en maladie trophoblastique persistante que ça soit une môle invasive ou choriocarcinome ou voire même une tumeur du site d'implantation placentaire; a remis en question cette stratégie. A travers une observation d'une môle partielle invasive métastatique, et à travers une revue de la littérature, on a essayé d'appuyer cette conduite qui considère la môle partielle comme une pathologie potentiellement grave nécessitant une prise en charge adéquate et une surveillance assez rigoureuse. PMID:25815096

  18. EcoTILLING revealed SNPs in GhSus genes that are associated with fiber- and seed-related traits in upland cotton

    PubMed Central

    Zeng, Yan-Da; Sun, Jun-Ling; Bu, Su-Hong; Deng, Kang-Sheng; Tao, Tao; Zhang, Yuan-Ming; Zhang, Tian-Zhen; Du, Xiong-Ming; Zhou, Bao-Liang

    2016-01-01

    Cotton is the most important textile crop in the world due to its cellulose-enriched fibers. Sucrose synthase genes (Sus) play pivotal roles in cotton fiber and seed development. To mine and pyramid more favorable alleles for cotton molecular breeding, single nucleotide polymorphisms (SNPs) of GhSus family genes were investigated across 277 upland cotton accessions by EcoTILLING. As a result, a total of 24 SNPs in the amplified regions of eight GhSus genes were identified. These SNPs were significantly associated with at least one fiber- or seed-related trait measured in Nanjing, Anyang and Kuche in 2007–2009. Four main-effect quantitative trait nucleotides (QTNs) and five epistatic QTNs, with 0.76–3.56% of phenotypic variances explained by each QTN (PVE), were found to be associated with yield-related traits; six epistatic QTNs, with the 0.43–3.48% PVE, were found to be associated with fiber quality-related traits; and one main-effect QTN and one epistatic QTN, with the PVE of 1.96% and 2.53%, were found to be associated with seed oil content and protein content, respectively. Therefore, this study provides new information for molecular breeding in cotton. PMID:27385639

  19. Grubbing by wild boars (Sus scrofa L.) and its impact on hardwood forest soil carbon dioxide emissions in Switzerland.

    PubMed

    Risch, Anita C; Wirthner, Sven; Busse, Matt D; Page-Dumroese, Deborah S; Schütz, Martin

    2010-11-01

    Interest in soil C storage and release has increased in recent years. In addition to factors such as climate/land-use change, vertebrate animals can have a considerable impact on soil CO(2) emissions. To date, most research has considered herbivores, while the impact of omnivorous animals has rarely been investigated. Our goal was to determine how European wild boars (Sus scrofa L.), large omnivores that consume soil-inhabiting animals and belowground plant parts by grubbing in the soil, affect soil C dynamics. We measured soil respiration (CO(2)), temperature, and moisture on paired grubbed and non-grubbed plots in six hardwood forest stands for a 3-year period and sampled fine root and microbial biomass at the beginning and after 2 years of the study. We also measured the percentage of freshly disturbed forest soil within the larger surroundings of each stand and used this information together with hunting statistics and forest cover data to model the total amount of CO(2) released from Swiss forest soils due to grubbing during 1 year. Soil CO(2) emissions were significantly higher on grubbed compared to non-grubbed plots during the study. On average 23.1% more CO(2) was released from these plots, which we associated with potential alterations in CO(2) diffusion rates, incorporation of litter into the mineral soil and higher fine root/microbial biomass. Thus, wild boars considerably increased the small-scale heterogeneity of soil properties. Roughly 1% of Switzerland's surface area is similar to our sites (boar density/forest cover). Given the range of forest soil disturbance of 27-54% at our sites, the geographic information system model predicted that boar grubbing would lead to the release of an additional 49,731.10-98,454.74 t CO(2) year(-1). These values are relatively small compared to total soil emissions estimated for Swiss hardwood forests and suggest that boars will have little effect on large-scale emissions unless their numbers increase and their

  20. The wild boar (Sus scrofa Linnaeus, 1758) as secondary reservoir of Fasciola hepatica in Galicia (NW Spain).

    PubMed

    Mezo, Mercedes; González-Warleta, Marta; Castro-Hermida, José Antonio; Manga-González, M Yolanda; Peixoto, Raquel; Mas-Coma, Santiago; Valero, M Adela

    2013-12-06

    Fasciolosis is an emerging or reemerging human and animal disease in numerous parts of the world. In Galicia (NW, Spain), the wild boar (Sus scrofa) is the main wild ungulate in terms of abundance and distribution. Its population has continuously increased over the past decades and this population growth has been accompanied by a reduction of habitats, so that the wild boar populations encroach more and more frequently onto agricultural lands. The increase of the interface area between livestock and the wild boars frequently involves the sharing of pastures and water sources, so that the circulation of common pathogens is propitiated. This is the first report concerning the importance of the wild boar as a possible reservoir of Fasciola hepatica infection in Spain. Livers from 358 hunted wild boars were analyzed showing that 11.2% were parasitized by F. hepatica, with burdens ranging from 1 to 14 flukes (mean=2.3). Fecal analysis demonstrated that 40.0% of parasitized animals shed F. hepatica eggs with a mean excretion of 6.1 eggs per gram of feces (epg). The presence of coproantigens analyzed by MM3-COPRO ELISA was positive in 62.9% of infected wild boars. After incubation, the percentage of hatched eggs ranged between 41.0% and 90.0% suggesting that the wild boar is very likely to contribute to the environmental contamination with viable parasite eggs. Comparative morphometric data were obtained using a computer image analysis system (CIAS) on the basis of standardized measurements. F. hepatica from cattle, sheep and wild boars from the same geographical area presents a similar body development and gravidity. Our study shows for the first time that the F. hepatica uterus from the wild boar presents an intermediate size between that found in primary reservoir hosts such as cattle and sheep, i.e., the individual potential egg output capacity of the wild boar does not greatly differ from that detected in Galician livestock. These results show that F. hepatica in

  1. An RNA-based analysis of changes in biodiversity indices in response to Sus scrofa domesticus decomposition.

    PubMed

    Bergmann, R C; Ralebitso-Senior, T K; Thompson, T J U

    2014-08-01

    Despite emergent research initiatives, significant knowledge gaps remain of soil microbiology-associated cadaver decomposition. Nevertheless, preliminary studies have shown that the vast diversity and complex interactions of soil microbial communities have great potential for forensic applications such as clandestine grave location and postmortem interval estimation. This study investigated changes in soil bacterial communities during pig (Sus scrofa domesticus) leg decomposition. 16S rRNA, instead of the usually applied 16S rDNA marker, was used to compare the metabolically active bacteria. Total bacterial RNA was extracted from soil samples of three different layers on day 3, 28 and 77 after the shallow burial of a pig leg. The V3 region of the 16S rRNA was amplified, analysed by RT-PCR DGGE, and compared with control soil bacterial community profiles. Statistically significant differences in soil bacterial biodiversity were observed. For the control, bacterial diversity (H') and species richness (S) of the three layers averaged 2.48±0.14 (H') and 18.8±2.5 (S), respectively, while for the test soil increases (p=0.027) were recorded between day 3 (H'=2.71±0.02; S=21.3±2.0) and 28 (H'=3.46±0.32; S=60.3±16.9), particularly in the middle (10-20 cm) and bottom (20-30 cm) soil layers. Between day 28 and 77 the diversity and richness then decreased on average for all three layers (H'=3.43±0.20; S=60.0±17.3) but remained higher than on day 3. Thus, responses in soil bacterial profiles and activity to carcass decomposition, detected and characterised by RNA-based DGGE, could be used together with RNA sequencing data, changes in physico-chemical variables (carbon, nitrogen, phosphorus, temperature, redox potential, water activity and pH) and conventional macroecology markers (e.g. insects and vegetation), to develop a suite of analytical protocols for different forensic scenarios.

  2. Les accidents de scooter chez l'enfant au CHU Aristide Le Dantec de Dakar: à propos de 74 cas

    PubMed Central

    Mohamed, Azhar Salim; Ngom, Gabriel; Sow, Mamadou; Mbaye, Papa Alassane; Camara, Souleymane; Seck, Ndeye Fatou; Ndour, Oumar

    2016-01-01

    Introduction Les accidents de scooter sont de plus en plus fréquents à Dakar. Le but de ce travail est de rapporter les aspects épidémiologiques et lésionnels des ces accidents chez l'enfant à Dakar. Méthodes Une étude rétrospective et descriptive a été menée dans le Service de Chirurgie Pédiatrique du CHU Aristide Le Dantec de Dakar entre le 1er janvier 2009 et le 31 décembre 2011. Nous avons étudié divers paramètres dont la fréquence, les aspects sociodémographiques et lésionnels. Résultats Les accidents de scooter représentaient 12% des accidents de la voie publique. Ils étaient fréquents entre 12 heures et 14 heures (27%) et entre 18 heures et 20 heures (28,4%). Ils pouvaient survenir tous les jours et étaient fréquents pendant les mois d'avril (17,6%) et de juin (13,5%). Ils survenaient essentiellement dans la périphérie de Dakar (78%). La tranche de 3 à 8 ans (60,8%) était la plus touchée. Le sexe masculin était prédominant (sexe ratio de 1,5). Les piétons étaient les plus vulnérables (93,2%). La chute était le mécanisme dominant (98,7%). Les lésions touchaient surtout le membre inférieur (51,1%) et étaient constituées essentiellement de fracture. Conclusion La fréquence des accidents de scooter chez l'enfant est liée à l'urbanisation galopante et à l'accroissement du parc automobile dans une presqu’île. Les victimes sont essentiellement des piétons et présentent le plus souvent des fractures. PMID:27200137

  3. Le traitement conservateur du cancer du sein: expérience d'une équipe tunisienne

    PubMed Central

    Dimassi, Kaouther; Gharsa, Anissa; Chanoufi, Mohammed Badis; Sfar, Ezzeddine; Chelli, Dalenda

    2014-01-01

    En Tunisie, le cancer du sein touche des femmes jeunes avec une taille moyenne au moment du diagnostic à 5 cm. Ces particularités font que la chirurgie radicale reste prédominante. Nous présentons dans ce travail l'expérience de notre équipe en matière de chirurgie conservatrice du cancer du sein. Le but de ce travail est d’évaluer les résultats de ce traitement. Etude rétrospective longitudinale, sur une période de 75 mois. Nous avons inclus toutes les patientes ayant bénéficié d'un traitement conservateur pour une tumeur maligne du sein. Ont été analysés: les caractéristiques épidémiologiques, les aspects radiologiques et histologiques. Le suivi des malades s'est basé sur la détection des récidives. Nous avons évalué le résultat esthétique à la fin de la radiothérapie. Le traitement conservateur a été réalisé dans 23.8% des cas. Le taux de récidives locales était de 6.8% avec une corrélation significative pour une taille tumorale > 30 mm (p= 0.009), l'association d'une composante intracanalaire (p= 0.035), le statut triple négatif (p= 0.003) et des marges d'exérèse < 5mm sans recoupes per-opératoires (p = 0.045). Les facteurs suivants étaient significativement liés au risque de survenue de métastases à distance: le statut triple négatif (p= 0.003), taille tumorale > 30mm (p = 0.006) et l'atteinte ganglionnaire (p = 0.001). Le résultat esthétique était satisfaisant dans 90% des cas. L'augmentation du nombre de patientes pouvant bénéficier d'une chirurgie conservatrice, doit passer impérativement par le développement et la promotion du diagnostic précoce et du dépistage par la mammographie. PMID:25810795

  4. Expression of LeNHX isoforms in response to salt stress in salt sensitive and salt tolerant tomato species.

    PubMed

    Gálvez, Francisco Javier; Baghour, Mourad; Hao, Gangping; Cagnac, Olivier; Rodríguez-Rosales, María Pilar; Venema, Kees

    2012-02-01

    In general, wild tomato species are more salt tolerant than cultivated species, a trait that is related to enhanced Na(+) accumulation in aerial parts in the wild species, but the molecular basis for these differences is not known. Plant NHX proteins have been suggested to be important for salt tolerance by promoting accumulation of Na(+) or K(+) inside vacuoles. Therefore, differences in expression or activity of NHX proteins in tomato could be at the basis of the enhanced salt tolerance in wild tomato species. To test this hypothesis, we studied the expression level of four NHX genes in the salt sensitive cultivated species Solanum lycopersicum L. cv. Volgogradskij and the salt tolerant wild species Solanum pimpinelifolium L in response to salt stress. First, we determined that in the absence of salt stress, the RNA abundance of LeNHX2, 3 and 4 was comparable in both species, while more LeNHX1 RNA was detected in the tolerant species. LeNHX2 and LeNHX3 showed comparable expression levels and were present in all tissues, while LeNHX4 was expressed above all in stem and fruit tissues. Next, we confirmed that the wild species was more tolerant and accumulated more Na(+) in aerial parts of the plant. This correlated with the observation that salt stress induced especially the LeNHX3 and LeNHX4 isoforms in the tolerant species. These results support a role of NHX genes as determinants of salt tolerance in tomato, inducing enhanced Na(+) accumulation observed in the wild species when grown in the presence of NaCl.

  5. Deriving fractional rate of degradation of logistic-exponential (LE) model to evaluate early in vitro fermentation.

    PubMed

    Wang, M; Sun, X Z; Tang, S X; Tan, Z L; Pacheco, D

    2013-06-01

    Water-soluble components of feedstuffs are mainly utilized during the early phase of microbial fermentation, which could be deemed an important determinant of gas production behavior in vitro. Many studies proposed that the fractional rate of degradation (FRD) estimated by fitting gas production curves to mathematical models might be used to characterize the early incubation for in vitro systems. In this study, the mathematical concept of FRD was developed on the basis of the Logistic-Exponential (LE) model, with initial gas volume being zero (LE0). The FRD of the LE0 model exhibits a continuous increase from initial (FRD 0) toward final asymptotic value (FRD F) with longer incubation time. The relationships between the FRD and gas production at incubation times 2, 4, 6, 8, 12 and 24 h were compared for four models, in addition to LE0, Generalization of the Mitscherlich (GM), c th order Michaelis-Menten (MM) and Exponential with a discrete LAG (EXPLAG). A total of 94 in vitro gas curves from four subsets with a wide range of feedstuffs from different laboratories and incubation periods were used for model testing. Results indicated that compared with the GM, MM and EXPLAG models, the FRD of LE0 model consistently had stronger correlations with gas production across the four subsets, especially at incubation times 2, 4, 6, 8 and 12 h. Thus, the LE0 model was deemed to provide a better representation of the early fermentation rates. Furthermore, the FRD 0 also exhibited strong correlations (P < 0.05) with gas production at early incubation times 2, 4, 6 and 8 h across all four subsets. In summary, the FRD of LE0 model provides an alternative to quantify the rate of early stage incubation, and its initial value could be an important starting parameter of rate.

  6. An Integrated Sediment Budget for the Le Sueur River in Southern Minnesota

    NASA Astrophysics Data System (ADS)

    Day, S. S.; Belmont, P.; Perg, L.; Johnson, A.; Gran, K.; Jennings, C.; Wilcock, P.

    2007-12-01

    The Le Sueur River is the primary sediment contributor to the Minnesota River, which is impaired by sediment under the Clean Water Act. The necessary first step toward developing a watershed management plan is identifying sediment sources and sinks throughout the basin. The focus of this study is to quantify the contribution of sediment from different sources in order to understand the broader problems affecting the larger Minnesota Basin. The lower Le Sueur River is actively incising in response to late Pleistocene baselevel fall on the Minnesota River, a result of the catastrophic draining of glacial Lake Agassiz. Potential sediment sources along the Le Sueur include high bluffs composed of highly consolidated Pre-Illinoisian, Illinoisian and Wisconsinin till and alluvial sediment, growing ravines and gullies, sediment exchange between the active channel and floodplains, as well as upland agricultural fields, which account for over 90% of the land surface. We applied side-scanning LiDAR to quantify the amount of sediment being eroded from the high bluffs and banks. To understand meander migration rates as well as ravine and gully retreat rates, and to supplement the understanding of bluff retreat rates, we have used aerial LiDAR along with comparative analysis of historic aerial orthophotos. The aerial LiDAR will also be used to calculate the volume of sediment being stored in the floodplains and terraces along the river, which will be used to create a floodplain exchange model. Preliminary results indicate that bluff retreat rates could be as high as 0.4 meters per year and meander bend migration rates up to 3 meters per year in isolated reaches of the watershed. Data collected from each potential source will be combined to create an overall sediment routing model for the watershed.

  7. The effect of Le Fort I maxillary impaction on nasal airway resistance.

    PubMed

    Guenthner, T A; Sather, A H; Kern, E B

    1984-04-01

    To evaluate the effect of maxillary superior movement via Le Fort I osteotomy on nasal airway resistance, eleven Caucasian patients whose surgical orthodontic treatment included Le Fort I impaction (range 2 to 8 mm, mean 5.3 mm) were selected. Nasal airway resistance in these patients was determined a few days before and approximately 8 weeks after the Le Fort I surgical procedure. Nasal airway resistance was determined by means of a uninasal active mask rhinomanometric technique. Contrary to the predicted negative effects of maxillary superior movement on nasal airway function, there was a statistically significant improvement in nasal airway resistance (P less than 0.01) after maxillary superior movement. This rather unexpected finding can be explained by examining the effect of maxillary superior movement on the nasal valve area in the anterior nose. The nasal valve area is a teardrop-shaped area bordered by the nasal septum, the caudal end of the upper lateral nasal cartilage, the floor of the nose, and the soft fibrofatty tissue on the lateral aspect of the nose. The apex of the teardrop-shaped area (the angle between the nasal septum and the upper lateral cartilage) is called the nasal valve. In the Caucasian type of nose, the nasal valve accounts for most of the inspiratory resistance to airflow. Maxillary superior movement increases the alar width. It is proposed that this increase in alar width is transmitted at least partially to the nasal valve angle, causing it to widen slightly, paradoxically reducing nasal airway resistance while reducing skeletal intranasal dimensions.

  8. Le lupus systémique juvénile familial: à propos de deux familles

    PubMed Central

    Krich, Sanaa; Inani, Kawtar; Meziane, Mariame; Souilmi, Fatima Zohta; Atmani, Samir; Hida, Mustapha; Harmouch, Taoufik; Amarti, Afaf; Mernissi, Fatima Zohra

    2015-01-01

    Le lupus érythémateux systémique (LES) juvénile est une connectivite rare, d’évolution plus sévère que chez l'adulte. Les cas familiaux sont exceptionnels. Il s'agissait de deux familles (5 patients atteints), chez qui on a objectivé un LES juvénile chez deux sæurs âgées de 14 ans et 6 ans respectivement chez la première famille, deux frères, âgés de 20 ans et 6 ans respectivement plus une sæur âgée de 10 ans chez la deuxième famille. Dans tout les cas le diagnostic de lupus systémique a été posé selon les nouveaux critères du groupe du SLICC (Systemic Lupus International Collaborating Clinics). Tous les patients ont été mis sous photoprotection, dermocorticoïdes et antipaludéens de synthèse sauf dans deux cas où la corticothérapie a été administrée. L’évolution a été favorable après le traitement dans la majorité des cas. Nous rapportons ces cas afin de discuter les particularités épidémiologiques, physiopathologiques, cliniques, paracliniques et thérapeutiques. PMID:26301023

  9. Contrôle de l'orientation et de l'alignement moléculaire par un train d'impulsions soudaines

    NASA Astrophysics Data System (ADS)

    Sugny, D.

    2006-10-01

    Les récents progrès technologiques dans le domaine des Lasers permettent d'envisager le contrôle de nombreux processus quantiques jouant un rôle dans une variété de problèmes s'étendant de la réactivité chimique à l'information quantique. Dans ce contexte, nous nous sommes intéressés au contrôle de l'orientation ou de l'alignement moléculaire en utilisant un train d'impulsions soudaines. Nous avons défini des états cibles qui maximisent à la fois l'orientation ou l'alignement et sa durée dans le temps et montré comment atteindre ces états à l'aide de stratégie systématique ou optimisée

  10. Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC : lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l’hépatite C chez les adultes

    PubMed Central

    Hull, Mark; Giguère, Pierre; Klein, Marina; Shafran, Stephen; Tseng, Alice; Côté, Pierre; Poliquin, Marc; Cooper, Curtis

    2014-01-01

    HISTORIQUE : De 20 % à 30 % des Canadiens qui vivent avec le VIH sont co-infectés par le virus de l’hépatite C (VHC), lequel est responsable d’une morbidité et d’une mortalité importantes. La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux OBJECTIF : Élaborer des normes nationales de prise en charge des adultes co-infectés par le VHC et le VIH dans le contexte canadien. MÉTHODOLOGIE : Le Réseau canadien pour les essais VIH des Instituts de recherche en santé du Canada a réuni un groupe d’experts possédant des compétences cliniques en co-infection par le VIH et le VHC pour réviser les publications à jour ainsi que les lignes directrices et les protocoles en place. Après une vaste sollicitation afin d’obtenir des points de vue, le groupe de travail a approuvé des recommandations consensuelles, qu’il a caractérisées au moyen d’une échelle de qualité des preuves fondée sur la classe (bienfaits par rapport aux préjudices) et sur la catégorie (degré de certitude). RÉSULTATS : Toutes les personnes co-infectées par le VIH et le VHC devraient subir une évaluation en vue de recevoir un traitement du VHC. Les personnes qui ne sont pas en mesure d’entreprendre un traitement du VHC devraient être soignées pour le VIH afin de ralentir l’évolution de la maladie hépatique. La norme de traitement du VHC de génotype 1 est un régime comprenant de l’interféron pégylé et de la ribavirine dosée en fonction du poids, associés à un inhibiteur de la protéase du VHC. Pour les génotypes 2 ou 3, une bithérapie classique est recommandée pendant 24 semaines s

  11. Implementing Frailty Screening, Assessment, and Sustained Intervention: The experience of the Gérontopôle.

    PubMed

    Vellas, B

    2015-06-01

    Despite its interest, frailty is not yet adequately implemented in the everyday clinical practice. Frailty is characterized by an initial functional loss which 1) still allows the individual to be independent in the daily life (although with some difficulties), and 2) may be reversed by targeted interventions. In the present article, we discuss: Why frailty is clinically relevant? Why frailty has not yet been implemented in daily clinical practice? How to implement frailty into clinical practice following the Gérontopôle experience? Intervention to be effective must be targeted, strong, and maintained.

  12. Le léiomyome vésical : À propos de 5 cas

    PubMed Central

    Saadi, Ahmed; Bouzouita, Abderrazak; Cherif, Mohamed; Ayed, Haroun; Derouiche, Amine; Ben Slama, Riadh Mohamed; Chebil, Mohamed

    2015-01-01

    Résumé Introduction : Les léiomyomes sont des tumeurs mésenchymateuses bénignes. La localisation vésicale de ces tumeurs est rare et représente moins de 0,5 % de toutes les tumeurs vésicales. Le léiomyome vésical est la plus fréquente de ces tumeurs mésenchymateuses et il représente le tiers des lésions bénignes de la vessie. Notre but était d’étudier les particularités épidémiologiques, cliniques, radiologiques, thérapeutiques et évolutives de ce type de tumeur. Matériel et méthodes : Nous rapportons une série de cinq cas de léiomyome vésical, colligés entre 2001 et 2014. Il s’agit de trois femmes et de deux hommes. La symptomatologie clinique est non spécifique et dominée par la cystite. Trois patients ont eu une énucléation et deux ont eu une résection endoscopique de la tumeur. Résultats : Le suivi moyen est de six ans. Un seul patient a présenté une récidive expliquée par la persistance d’un nodule vésical lors de la première intervention, avec une bonne évolution après la deuxième cure chirurgicale. Conclusion : Le léiomyome vésical est une tumeur bénigne et rare. Sa symptomatologie est peu spécifique. Son diagnostic est histologique. Son traitement est toujours chirurgical, offrant un excellent pronostic, sous réserve d’une exérèse complète pour éviter les récidives. PMID:26279718

  13. The Portevin-Le Chatelier effect in an Al-Mg alloy

    NASA Astrophysics Data System (ADS)

    Mogucheva, Anna; Saenko, Mikhail; Kaibyshev, Rustam

    2016-11-01

    The Portevin-Le Chatelier (PLC) effect has been studied in an Al-Mg alloy. A series off tensile tests was carried out at temperatures ranging from -100 to 150°C at plastic strain rates ranging from a low 10-1 s-1 to a high of 10-5 s-1. The coarse-grained material displays tensile curves typical of Al-Mg alloys with an extensive initial strain hardening and an overall parabolic shape until necking. Mixed type (A + B) serrations take place during the strain hardening stage.

  14. Failure Analysis and Prevention for the Air Logistics Center Engineer: CAStLE Course Development Summary

    DTIC Science & Technology

    2006-09-01

    also, as structure Enginer this class has a lot of information that will keep us up todate and we can apply to problems that we deal on daily basis...CAStLE course was directly on target with the current needs of the ALC engineer. This specialized course was delivered on-site with up -to-date...programs, the Engineering Directorate seeks to ensure their engineers are up to date in topics which are relevant to the ALC engineer. To this end, they

  15. Investigation of Portevin-Le Chatelier band with temporal phase analysis of speckle interferometry

    NASA Astrophysics Data System (ADS)

    Jiang, Zhenyu; Zhang, Qingchuan; Wu, Xiaoping

    2003-04-01

    A new method combining temporal phase analysis with dynamic digital speckle pattern interferometry is proposed to study Portevin-Le Chatelier effect quantitatively. The principle bases on that the phase difference of interference speckle patterns is a time-dependent function related to the object deformation. The interference speckle patterns of specimen are recorded with high sampling rate while PLC effect occurs, and the 2D displacement map of PLC band and its width are obtained by analyzing the displacement of specimen with proposed method.

  16. Influence of Portevin Le Chatelier effect on rupture mode of alloy 718 specimens

    NASA Astrophysics Data System (ADS)

    Garat, V.; Cloue, J.-M.; Poquillon, D.; Andrieu, E.

    2008-03-01

    A set of tensile tests has been carried out under air environment in the temperature range (450-700 °C) in order to characterize the interactions between oxidation assisted intergranular cracking and Portevin-Le Chatelier effect. It is shown that the occurrence of jerky flow stops the intergranular damaging mechanism. The construction of a temperature versus strain rate diagram showing dynamic strain aging, intergranular fracture and PLC instabilities locations is then proposed. The surprising relation between crack initiation disappearance and PLC instabilities of type C in the temperature range explored is discussed. Finally the assumption of the occurrence of such phenomenon at the tip of a propagating crack is addressed.

  17. An Unusual Lacerated Tracheal Tube during Le Fort Surgery: Literature Review and Case Report

    PubMed Central

    George, Preeta; Fiadjoe, John E.

    2016-01-01

    Maxillofacial surgeries can present unique anesthetic challenges due to potentially complex anatomy and the close proximity of the patient's airway to the surgical field. Damage to the tracheal tube (TT) during maxillofacial surgery may lead to significant airway compromise. We report the management of a patient with a partially severed TT during Le Fort surgery for midfacial hypoplasia and management strategies based on peer-reviewed literature. This case illustrates the clinical clues associated with a damaged TT and explores the challenges of managing this potentially catastrophic issue. PMID:27895942

  18. Factors controlling growth and morphology of early Miocene stromatolites from Montaigu-le-Blin, France

    NASA Astrophysics Data System (ADS)

    Bontognali, Tomaso R. R.; Barilaro, Federica; McKenzie, Judith A.; Vasconcelos, Crisogono

    2015-04-01

    A large variety of stromatolite morphotypes are present in the early Miocene sedimentary sequence that outcrops in the region of Montaigu-le-Blin, France. Thanks to its good degree of preservation, this formation is an ideal place to evaluate the key factors controlling the occurrence and morphology of the stromatolites, as well as to study the diagenetic processes that transform a soft, slimy lithifying microbialite into a solid, laminated sedimentary rock. Facies analysis suggests that the Montaigu-le-Blin stromatolites formed in shallow waters, in a restricted, laterally heterogeneous basin. Various evidence suggests a biological origin for the stromatolites, whose formation cannot be explained through abiotic background precipitation driven by evaporation, temperature changes, or migration of metamorphic fluids. Microscopic observations revealed that the Montaigu-le-Blin stromatolites are mainly comprised of authigenic calcite that precipitated directly from the basin waters (no evidence for trapping and binding) in close association with algae, microbial cells, and exopolymeric substances. Well-preserved microfossils of photosynthetic organisms are widespread within the thin sections. The calcite constituting the stromatolites is characterized by positive δ13C values (1.7 to 4.4 o), suggesting that microbial mediation of calcite was mainly related to the metabolic activity of photosynthetic organisms or anoxygenic phototrophs, and not to metabolisms in which organic material is degraded (e.g. sulfate reduction). The laminated habit of the stromatolites results from alternating layers of porous, digit-like sparite and more compacted organic-rich micrite. No correlation was identified, through isotopic analysis, between these two types of laminae and external environmental factors (i.e. temperature, salinity, eutrophication state). Rather, we hypothesize that periodic fluctuations in the dominant microbial/algal species within the mat influenced the morphology

  19. Frequency Assignment, Sharing and Conservation in Systems (Aerospace). (l’Attribution, le partage et la conservation des frequences pour les systemes aeronautiques et spatiales)

    DTIC Science & Technology

    1999-01-01

    naturels du terrain (helicopteres et missiles de croisiere) et/ou des vitesse tres elevees, • des potentialites de contre mesure electroniques...pour les besoins de CEM. Concernant l’impact de remission radar sur les systemes de communication, le diagramme naturel d’antenne permet de...in RTO MP-13. 8-2 le faible nombre de capteur des antennes exploitees. AIRSYS a valide, avec le concours du SPOTI, les performances d’algorithmes

  20. 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les operations en coalition)

    DTIC Science & Technology

    2010-02-01

    Feb 2010 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en...RTO MEETING PROCEEDINGS MP-MSG-079 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de...RTO-MP-MSG-079 ES - 3 Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en coalition (RTO-MP-MSG-079

  1. Dimensions of Velopharyngeal Space following Maxillary Advancement with Le Fort I Osteotomy Compared to Zisser Segmental Osteotomy: A Cephalometric Study

    PubMed Central

    Karabekmez, Furkan Erol; Kleinheinz, Johannes; Jung, Susanne

    2015-01-01

    The objectives of this study are to assess the velopharyngeal dimensions using cephalometric variables of the nasopharynx and oropharynx as well as to compare the Le Fort I osteotomy technique to Zisser's anterior maxillary osteotomy technique based on patients' outcomes within early and late postoperative follow-ups. 15 patients with severe maxillary deficiency treated with Le Fort I osteotomy and maxillary segmental osteotomy were assessed. Preoperative, early postoperative, and late postoperative follow-up lateral cephalograms, patient histories, and operative reports are reviewed with a focus on defined cephalometric landmarks for assessing velopharyngeal space dimension and maxillary movement (measured for three different tracing points). A significant change was found between preoperative and postoperative lateral cephalometric measurements regarding the distance between the posterior nasal spine and the posterior pharyngeal wall in Le Fort I osteotomy cases. However, no significant difference was found between preoperative and postoperative measurements in maxillary segmental osteotomy cases regarding the same measurements. The velopharyngeal area calculated for the Le Fort I osteotomy group showed a significant difference between the preoperative and postoperative measurements. Le Fort I osteotomy for advancement of upper jaw increases velopharyngeal space. On the other hand, Zisser's anterior maxillary segmental osteotomy does not alter the dimension of the velopharyngeal space significantly. PMID:26273615

  2. STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro

    PubMed Central

    2010-01-01

    Background LePRK1 and LePRK2 are two pollen receptor kinases localized to the plasma membrane, where they are present in a high molecular weight complex (LePRK complex). LePRK2 is phosphorylated in mature and germinated pollen, but is dephosphorylated when pollen membranes are incubated with tomato or tobacco style extracts. Results Here we show that LePRK2 dephosphorylation is mediated by a heat-, acid-, base-, DTT- and protease-resistant component from tobacco styles. Using LePRK2 phosphorylation as a tracking assay for purification, style exudates were subjected to chloroform extraction, anionic exchange, and C18 reverse-phase chromatography columns. We finally obtained a single ~3,550 Da compound (as determined by UV-MALDI-TOF MS) that we named STIL (for Style Interactor for LePRKs). STIL increased pollen tube lengths of in vitro germinated pollen in a dose-dependent manner. Conclusion We propose that the LePRK complex perceives STIL, resulting in LePRK2 dephosphorylation and an increase in pollen tube growth. PMID:20175921

  3. Statistical behavior and strain localization patterns in the Portevin-Le Chatelier effect

    SciTech Connect

    Lebyodkin, M.; Brechet, Y.; Estrin, Y.; Kubin, L.

    1996-11-01

    Statistics of the stress drops associated with the Portevin-Le Chatelier effect in an Al-Mg alloy were studied both experimentally and theoretically. It was shown that the character of the statistics changes from a peaked distribution of the stress drop magnitudes to a monotonically decreasing one as the imposed strain rate or the temperature are increased. A discrete model based on a micromechanically founded local constitutive equation combined with spatial coupling between the elements of the system was shown to reproduce the observed statistical behavior. The mechanism of spatial coupling is connected with elastic stresses due to local plastic incompatibilities. The model was further applied to simulate spatial deformation patterns including propagative deformation bands. The systematics of the bands reported in the literature as well as the observed dependence of the band velocity on the imposed deformation rate were recovered. It was concluded that the model proposed provides an adequate description of both the statistics of stress discontinuities and the spatial features of the Portevin-Le Chatelier effect.

  4. Scale insect larvae preserved in vertebrate coprolites (Le Quesnoy, France, Lower Eocene): paleoecological insights.

    PubMed

    Robin, Ninon; Foldi, Imre; Godinot, Marc; Petit, Gilles

    2016-10-01

    Coprolites of terrestrial vertebrates from the Sparnacian Le Quesnoy locality (Ypresian, Eocene, MP7, 53 Ma; Oise, France) were examined for possible parasitic helminth eggs. The extraction of the coprolite components was performed by a weak acetolyse and a slide mounting in glycerin. This long examination did not reveal paleoparasite remains, which may be explained through several arguments. However, some pollen grains, some enigmatic components, and two well-preserved first-instar cochineal nymphs (Hemiptera: Sternorrhyncha: Coccoidea) were evidenced in coprolites. Identified as Coccidae, these larvae are the earliest stage of the scale insect development ever reported as fossil, revealing the specific environment of preservation that fossilized scats may provide. These observations, combined to the coprolites morphotype, enable to ascribe the fossil scats producer to a small herbivorous mammal present in the deposit (early perissodactyls or Plesiadapidae). Regarding the ecology of extant representatives of Coccidae, this mammal was a likely foliage consumer, and the abundant Juglandaceae and/or Tiliaceae from Le Quesnoy might have lived parasitized by scale insects. These Early Eocene parasites had an already well-established dissemination strategy, with prevalent minute first-instar larvae. The herein performed extraction technique appears well-suited for the study of carbonate coprolites and could certainly be useful for evidencing other kind of microorganisms (including internal parasites).

  5. Le Fort I osteotomy to enucleation of grand proportions fissural cyst-presentation of case report.

    PubMed

    Cavalcante, Rafael Correia; Durski, Fernanda; Deliberador, Tatiana Miranda; Giovanini, Allan Fernando; Rebellato, Nelson Luís Barbosa; da Costa, Delson João; Klüppel, Leandro Eduardo; Scariot, Rafaela

    2016-01-01

    Fissural cysts (FC) are caused by entraped epithelium between nasal and maxilar processes. They are commonly treated with surgical enucleation precedded or not by marsupialization depending on the cyst size. Biopsy of lesion is recommended due to confirm radiographic evaluation. It is rare to observe Le Fort I surgical approach to this type of injury. This study reports the case of an uncommon grand proportions fissural cyst in a female patient, 53, that was referred to the Oral and Maxillofacial Surgery Departament of Hospital XV presenting volume increase in maxilla associated with numbness of palate. Radiograph examination showed an intimate relationship between incisors apexes and FC. Expansion of both buccal and palate cortical was then confirmed as well as its unusual size, approximately 25 millimeters. Due to the abnormal size of lesion and possible impairment of upper incisors, LeFort I osteotomy associated with downfracture to cystic enucleation was the chosen treatment. After enucleation, the remaining space was filled with BIOSs and bioguide (lyophilized bone and collagen membrane). Patients' twelve months follow-up demonstrate no relapses and maintenance of teeth involved.

  6. Application of a flush airdata sensing system to a wing leading edge (LE-FADS)

    NASA Technical Reports Server (NTRS)

    Whitmore, Stephen A.; Moes, Timothy R.; Czerniejewski, Mark W.; Nichols, Douglas A.

    1993-01-01

    The feasibility of locating a flush airdata sensing (FADS) system on a wing leading edge where the operation of the avionics or fire control radar system will not be hindered is investigated. The leading-edge FADS system (LE-FADS) was installed on an unswept symmetrical airfoil and a series of low-speed wind-tunnel tests were conducted to evaluate the performance of the system. As a result of the tests it is concluded that the aerodynamic models formulated for use on aircraft nosetips are directly applicable to wing leading edges and that the calibration process is similar. Furthermore, the agreement between the airdata calculations for angle of attack and total pressure from the LE-FADS and known wind-tunnel values suggest that wing-based flush airdata systems can be calibrated to a high degree of accuracy. Static wind-tunnel tests for angles of attack from -50 deg to 50 deg and dynamic pressures from 3.6 to 11.4 lb/sq ft were performed.

  7. MONOX: un nouveau spectrogoniomètre pour le rayonnement X mou et X-UV

    NASA Astrophysics Data System (ADS)

    André, J.-M.; Avila, A.; Barchewitz, R.; Benbalagh, R.; Delaunay, R.; Druart, D.; Fontaine, M.-F.; Ringuenet, H.

    2004-11-01

    Un spectrogoniomètre de laboratoire utilisant comme source un tube émettant des radiations caractéristiques dans le domaine X mou et X-UV a été développé au Laboratoire de Chimie Physique (CNRS/UPMC) dans le cadre de l'Action Coordonnée Optique du CNRS. L'appareil comprend un monochromateur de type “double-cristaux" équipé de miroirs multicouches ou de cristaux de grande période et un goniomètre θ-2θ . Il permet des mesures de pouvoir réflecteur et de diffusion de dispositifs optiques, en particulier de miroirs et réseaux multicouches. Dans un futur proche il sera aussi destiné à la caractérisation de nouvelles sources et de détecteurs X-UV. L'appareil peut aussi être utilisé comme spectromètre à cristal plan si l'anode est remplacée par l'échantillon à analyser. Différents exemples des possibilités offertes par cet instrument opérant en mode “réflectométrie" ou en mode “spectrométrie" sont présentés.

  8. Etude des interdiffusions en phase solide dans le contact Ni/AlAs

    NASA Astrophysics Data System (ADS)

    Députier, S.; Guivarc'h, A.; Caulet, J.; Poudoulec, A.; Guenais, B.; Minier, M.; Guérin, R.

    1995-04-01

    éposée dans des conditions d'ultra-vide et des couches épaisses d'AlAs épitaxiées sur des substrats de GaAs orientés (001) et (111) ont été étudiées après des traitements thermiques d'une heure, sous balayage de gaz neutres, entre 200 et 600 ^{circ}C. L'utilisation de techniques complémentaires d'analyse (RBS, diffraction X, MET) a permis de mettre en évidence, en fonction de la température de recuit, plusieurs étapes successives d'interaction. Ces étapes correspondent soit à des phases ternaires, mises en évidence lors de la détermination expérimentale du diagramme Ni-Al-As et notées A, B, D par analogie avec celles du diagramme Ni-Ga-As, soit à des mélanges de phases constituées de binaires et/ou de ternaires, toutes ces phases étant plus ou moins fortement texturées sur le substrat. En fait, la nature des phases en présence dépend de l'orientation du substrat, la cinétique de réaction apparaissant plus lente pour l'interaction Ni/AlAs(111) que pour celle Ni/AlAs(001), les étapes successives sont observées : tout d'abord un mélange constitué de la phase ternaire B + NiAl puis un autre mélange : phase ternaire A + NiAl + NiAs et en fin d'interaction les deux binaires : NiAl + NiAs. Sur AlAs(111), seules deux étapes sont mises en évidence, la première correspond à la phase ternaire D, la seconde, en fin d'interaction, est constituée du mélange : phase B + NiAl + NiAs. On remarque dans ce cas le recuit à 600 ^{circ}C n'est pas suffisant pour atteindre le mélange des binaires NiAl et NiAs qui, selon le diagramme ternaire, est le stade ultime de l'interaction Ni/AlAs. L'analyse comparée des interdiffusions Ni/AlAs et Ni/GaAs montre que NiAl est le composé “clé” autour duquel pivote l'interaction Ni/AlAs alors que ce rôle était joué par NiAs lors des interdiffusions Ni/GaAs. Thermiquement stable et fortement texturé sur AlAs, le binaire NiAl apparaît comme un candidat prometteur pour la réalisation d'hétérostructures NiAl/AlAs/GaAs.

  9. Le Chatelier's principle in sensation and perception: fractal-like enfolding at different scales.

    PubMed

    Norwich, Kenneth H

    2010-01-01

    Le Chatelier's principle asserts that a disturbance, when applied to a resting system may drive the system away from its equilibrium state, but will invoke a countervailing influence that will counteract the effect of the disturbance. When applied to the field of sensation and perception, a generalized stimulus will displace the system from equilibrium, and a generalized adaptation process will serve as the countervailing influence tending to reduce the impact of the stimulus. The principle applies at all levels, from the behavioral to the neural, the larger enfolding the smaller in fractal-like form. Le Chatelier's principle, so applied, leads to the unification of many concepts in sensory science. Ideas as diverse as sensory adaptation, reflex arcs, and simple deductive logic can be brought under the umbrella of a single orienting principle. Beyond unification, this principle allows us to approach many questions in pathophysiology from a different perspective. For example, we find new direction toward the reduction of phantom-limb pain and possibly of vertigo.

  10. Scale insect larvae preserved in vertebrate coprolites (Le Quesnoy, France, Lower Eocene): paleoecological insights

    NASA Astrophysics Data System (ADS)

    Robin, Ninon; Foldi, Imre; Godinot, Marc; Petit, Gilles

    2016-10-01

    Coprolites of terrestrial vertebrates from the Sparnacian Le Quesnoy locality (Ypresian, Eocene, MP7, 53 Ma; Oise, France) were examined for possible parasitic helminth eggs. The extraction of the coprolite components was performed by a weak acetolyse and a slide mounting in glycerin. This long examination did not reveal paleoparasite remains, which may be explained through several arguments. However, some pollen grains, some enigmatic components, and two well-preserved first-instar cochineal nymphs (Hemiptera: Sternorrhyncha: Coccoidea) were evidenced in coprolites. Identified as Coccidae, these larvae are the earliest stage of the scale insect development ever reported as fossil, revealing the specific environment of preservation that fossilized scats may provide. These observations, combined to the coprolites morphotype, enable to ascribe the fossil scats producer to a small herbivorous mammal present in the deposit (early perissodactyls or Plesiadapidae). Regarding the ecology of extant representatives of Coccidae, this mammal was a likely foliage consumer, and the abundant Juglandaceae and/or Tiliaceae from Le Quesnoy might have lived parasitized by scale insects. These Early Eocene parasites had an already well-established dissemination strategy, with prevalent minute first-instar larvae. The herein performed extraction technique appears well-suited for the study of carbonate coprolites and could certainly be useful for evidencing other kind of microorganisms (including internal parasites).

  11. Toward a midisuperspace quantization of LeMaitre-Tolman-Bondi collapse models

    SciTech Connect

    Vaz, Cenalo; Witten, Louis; Singh, T. P.

    2001-05-15

    LeMaitre-Tolman-Bondi models of spherical dust collapse have been used and continue to be used extensively to study various stellar collapse scenarios. It is by now well known that these models lead to the formation of black holes and naked singularities from regular initial data. The final outcome of the collapse, particularly in the event of naked singularity formation, depends very heavily on quantum effects during the final stages. These quantum effects cannot generally be treated semiclassically as quantum fluctuations of the gravitational field are expected to dominate before the final state is reached. We present a canonical reduction of LeMaitre-Tolman-Bondi space-times describing the marginally bound collapse of inhomogeneous dust, in which the physical radius R, the proper time of the collapsing dust {tau}, and the mass function F are the canonical coordinates R(r), {tau}(r) and F(r) on the phase space. Dirac's constraint quantization leads to a simple functional (Wheeler-DeWitt) equation. The equation is solved and the solution can be employed to study some of the effects of quantum gravity during gravitational collapse with different initial conditions.

  12. LeFort I segmented osteotomy experience with piezosurgery in orthognathic surgery

    PubMed Central

    Olate, Sergio; Pozzer, Leandro; Unibazo, Alejandro; Huentequeo-Molina, Claudio; Martinez, Felipe; de Moraes, Márcio

    2014-01-01

    The aim of this work was to present the LeFort I segmented osteotomy in consecutive patients using the piezoelectric system. A descriptive study was designed for patients operated on between November 2012 and January 2014. All the patients presented some type of skeletal anomaly and underwent orthognatic surgery via piezoelectric osteotomies. Each maxillary surgery was developed with that system and those patients who also received osteotomies with a reciprocating saw were excluded. Surgical time and complications were analyzed. 19 patients underwent surgery consecutively with an osteotomy average time of 45 minutes. The patients operated on at the beginning were longer surgeries, whereas the final cases were 40 minutes. No type of laceration of vascular elements or laceration of palatal tissue was observed. The protocol was fully implemented, incorporating all the advantages of piezoelectric systems. It is concluded that the LeFort I segmented osteotomy can be performed with low risk of injuring soft tissues and in a time probably less than 50 minutes for the maxillary osteotomy. PMID:25232392

  13. Un nouveau cristal laser largement accordable le BOYS dopé à l'ytterbium

    NASA Astrophysics Data System (ADS)

    Chénais, S.; Druon, F.; Balembois, F.; Georges, P.; Gaumé, R.; Aka, G.; Viana, B.; Vivien, D.

    2002-06-01

    Nous avons étudié les performances laser en pompage par diode de puissance d'un nouveau cristal : le Sr3Y(BO3)3 (acronyme : BOYS), dopé à l'ytterbium. Son spectre d'émission particulièrement large en fait un matériau particulièrement prometteur pour la réalisation de lasers femtosecondes directement pompés par diode. Ses performances ont été comparées à celles d'un verre phosphate ainsi qu'à celles du cristal d' Yb:GdCOB dans les mêmes conditions. Nous démontrons que, tant du point de vue de l'efficacité laser que de la tenue aux fortes puissances, GdCOB et BOYS sont supérieurs au verre ; le BOYS est de surcroît plus accordable (sur 50 nm), mais son comportement thermique limite a priori son usage à des puissances de pompe modérées.

  14. The effects of guided tissue regeneration (GTR) on modified Le Fort I osteotomy healing in rabbits.

    PubMed

    Verschueren, D S; Gassner, R; Mitchell, R; Mooney, M P

    2005-09-01

    Osteogenesis following surgery depends on the osteoblasts at the wound site. Fibrous nonunions may be the result of differential and rapid migration of fibroblasts compared to osteoblasts into the wound. The present study was designed to test this hypothesis through the use of guided tissue regeneration (GTR) in a rabbit model. Bilateral, Le Fort I osteotomies (n=20) were produced in the maxillae of 10 New Zealand White rabbits. The segments were advanced 6mm and rigidly fixed using microplates and screws. One side was covered with a resorbable collagen membrane or left uncovered. Rabbits were followed for four weeks with radiographs and the maxillae were harvested for histology. Cephalometry revealed that membrane-covered defects had significantly (P<0.01) reduced defect area (by approximately 70%) compared to uncovered defects. Histologically, membrane-covered defects showed more organized osteogenesis and less fibrous tissue than uncovered defects. Histomorphometry revealed that membrane covered defects had significantly (P<0.05) reduced defect areas (by approximately 20%) compared to uncovered defects. While findings suggest that GTR can facilitate osseous wound healing in Le Fort I osteotomies, results also caution against relying exclusively on two-dimensional radiography to assess bony wound healing in lieu of three-dimensional imaging and evaluations.

  15. LeFort I segmented osteotomy experience with piezosurgery in orthognathic surgery.

    PubMed

    Olate, Sergio; Pozzer, Leandro; Unibazo, Alejandro; Huentequeo-Molina, Claudio; Martinez, Felipe; de Moraes, Márcio

    2014-01-01

    The aim of this work was to present the LeFort I segmented osteotomy in consecutive patients using the piezoelectric system. A descriptive study was designed for patients operated on between November 2012 and January 2014. All the patients presented some type of skeletal anomaly and underwent orthognatic surgery via piezoelectric osteotomies. Each maxillary surgery was developed with that system and those patients who also received osteotomies with a reciprocating saw were excluded. Surgical time and complications were analyzed. 19 patients underwent surgery consecutively with an osteotomy average time of 45 minutes. The patients operated on at the beginning were longer surgeries, whereas the final cases were 40 minutes. No type of laceration of vascular elements or laceration of palatal tissue was observed. The protocol was fully implemented, incorporating all the advantages of piezoelectric systems. It is concluded that the LeFort I segmented osteotomy can be performed with low risk of injuring soft tissues and in a time probably less than 50 minutes for the maxillary osteotomy.

  16. Structure of a SusD Homologue, BT1043, Involved in Mucin O-Glycan Utilization in a Prominent Human Gut Symbiont

    SciTech Connect

    Koropatkin, Nicole; Martens, Eric C.; Gordon, Jeffrey I.; Smith, Thomas J.

    2009-05-21

    Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth. The molecular basis of host glycan recognition by this species is still unknown but likely occurs through an expanded suite of outermembrane glycan-binding proteins that are the primary interface between B. thetaiotaomicron and its environment. Presented here is the atomic structure of the B. thetaiotaomicron protein BT1043, an outer membrane lipoprotein involved in host glycan metabolism. Despite a lack of detectable amino acid sequence similarity, BT1043 is a structural homologue of the B. thetaiotaomicron starch-binding protein SusD. Both structures are dominated by tetratrico peptide repeats that may facilitate association with outer membrane {beta}-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of {beta}-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. This is in contrast to CBM 32 family members that target the terminal nonreducing galactose residue of mucin glycans. The highly articulated glycan-binding pocket of BT1043 suggests that binding of ligands to BT1043 relies more upon interactions with the composite sugar residues than upon overall ligand conformation as previously observed for SusD. The diversity in amino acid sequence level likely reflects early divergence from a common ancestor, while the unique and conserved {alpha}-helical fold the SusD family suggests a similar function in glycan uptake.

  17. Le Pseudomonas: Experience du Centre des Brules D’Annaba et Revue de la Litterature

    PubMed Central

    Chaibdraa, A.; Medjellekh, M.S.; Saouli, A.; Bentakouk, M.C.

    2008-01-01

    Summary Le Pseudomonasest un agent pathogène à l'origine d'infections nosocomiales graves dans les centres des brûlés. Son opportunisme et sa virulence en font une préoccupation majeure. Ce travail se propose d'évaluer la place de cette bactérie dans l'écologie bactérienne locale et d'en apprécier la sensibilité aux antibiotiques. Cette étude rétrospective préliminaire porte sur la période de juin 2003 à décembre 2005. Elle intéresse l'ensemble des prélèvements bactériologiques ayant pu être réalisés au centre des brûlés d'Annaba. L'effectif est de 633 micro-organismes isolés dont 128 Pseudomonas (20,2%): 127 aeruginosa (99,2%), 1 fluorescens (0,8%); distribution selon le site de prélèvement: écouvillon (87,5%), prélèvement trachéobronchique (4,6%), hémoculture (3,1%), cathéters (1,6%), urine (1,6%) et sonde urinaire (1,6%). Le pyocyanique se situe après le staphylocoque pour les prélèvements précoces et repasse en tête après un séjour supérieur à une semaine, où 89% des pyocyaniques sont identifiés. Il est en première position dans les pneumopathies sous ventilation assistée invasive. Il se classe troisième dans les hémocultures et les cultures de cathéters. Dans les infections urinaires il est devancé par Candida et la flore périnéale. Les 128 antibiogrammes regroupent 314 réponses sensibles. La sensibilité à plus de deux antibiotiques est de 68%, à deux antibiotiques 24% et à un antibiotique 8%. Seules quatre molécules restent actives: ciprofloxacine > péfloxacine > pipéracilline > ceftazidime. Une résistance absolue est retrouvée pour trois Pseudomonas (2,4%). Le pronostic sévère des infections nosocomiales à pyocyanique et les risques d'options thérapeutiques très limitées font toute leur gravité, d'où l'intérêt de respecter des règles strictes de prescription des antibiotiques et des mesures de prévention. PMID:21991140

  18. le of dielectric effects in the red-green switching of porous silicon luminescence

    NASA Astrophysics Data System (ADS)

    Chazalviel, J.-N.; Ozanam, F.; Dubin, V. M.

    1994-09-01

    Trapping of a carrier at an ionized impurity in porous silicon may be significantly hindered when the material is embedded in a high-dielectric-constant medium such as an aqueous electrolyte. This effect is estimated for a geometry of cylindrical silicon wires, and by modeling the two media with wavevector-independent dielectric constants. The self-image potential of the electron is taken into account, and the frequency dependence of the outer dielectric constant is treated in a simple manner. The results demonstrate that the impurity states are not accessible in the presence of the electrolyte, just due to the dielectric relaxation of the embedding medium. This result may apply to different kinds of localized electronic states, including those responsible for the red luminescence in dry porous silicon. This provides a plausible explanation for the red to green switching of the luminescence when the porous silicon is wet and suggests that using embedding media of intermediate dielectric constants should allow one to observe a progressive transition between red and green luminescence. Observation of porous silicon luminescence in solvents of various dielectric constants provides a preliminary test of this prediction. Le piégeage d'un porteur par une impureté ionisée dans le silicium poreux peut devenir inefficace lorsque le matériau est plongé dans un milieu de grande constante diélectrique tel qu'un électrolyte aqueux. Cet effet est estimé pour une géométrie de filaments cylindriques de silicium, les deux milieux étant modélisés par des constantes diélectriques indépendantes du vecteur d'onde. Le potentiel image de l'électron est pris en considération, et la dépendance en fréquence de la constante diélectrique du milieu extérieur est traitée de manière simple. Les résultats démontrent que les états liés sur l'impureté ne sont pas accessibles en présence de l'électrolyte, simplement en raison de la relaxation diélectrique de ce milieu

  19. Place de la bili-IRM dans le diagnostic etiologique des icteres cholestatiques à Dakar

    PubMed Central

    Badji, Nfally; Akpo, Geraud; Deme, Hamidou; Toure, Mouhamadou Hamine; Ly, Mamadou; Ndong, Boucar; Niang, El Hadji

    2016-01-01

    La Bili-IRM est une méthode diagnostique d’introduction relativement récente dans l’arsenal d’exploration de la pathologie bilio-pancréatique. Il s’agit d’une technique fiable reproductible et non invasive, permettant la visualisation directe des voies biliaires et pancréatiques. Le but de ce travail était d’étudier les aspects morphologiques des principales anomalies et d’évaluer la place de la bili-IRM dans le diagnostic étiologique des ictères cholestatiques. Il s’agit d’une étude rétrospective réalisée sur 4 ans et six mois (Janvier 2008 à Juillet 2012) portant sur 17 patients colligés dans les services d’imagerie médicale du CHUN de Fann et de l’hôpital Principal de Dakar. Tous les patients ont bénéficié d’une IRM (1,5T) avec des protocoles adaptés en fonction de la pathologie explorée. Les dossiers retenus sont ceux dont le diagnostic a été établi à partir du bilan biologique et ayant bénéficié à la fois d’une bili-IRM et d’une exploration chirurgicale. Il s’agissait de 05 femmes et de 12 hommes soit un sexe ratio de 2.4. L’âge moyen des patients était de 58 ans avec des extrêmes de 35 et 81 ans. Les tumeurs de Klatskin étaient observées chez 07 patients avec une forme infiltrante dans 71% des cas et une forme exophytique dans 28% des cas. Les cancers de la vésicule biliaire étaient notés dans 28% des cas. Les cancers de la tête du pancréas représentaient 28% des cas. La lithiase de la voie biliaire principale était présente chez 05 patients avec un empierrement cholédocien dans 60% des cas et une lithiase unique dans 40% des cas. Toutes ces lésions étaient responsables d’une dilatation des VBIH. Un cas de dilatation des voies biliaires intra et extra hépatiques était retrouvé sans cause bilio-pancréatique. La bili-IRM est l’examen de choix dans l’exploration des ictères cholestatiques. Elle doit être demandée en première intention lorsqu’on suspecte une lithiase r

  20. The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies.

    PubMed

    de Lange, J; Baas, E M; Horsthuis, R B G; Booij, A

    2008-01-01

    Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the effect on blood loss of cocaine/adrenaline application to the nasal floor is presented. Thirty patients who underwent a Le Fort I procedure were randomized for cocaine/adrenaline application. Blood loss and duration of surgery were registered for both groups. The results showed a significant reduction of blood loss in the group with cocaine/adrenaline application (P<0.001), but no significant difference in operating time. No side effects were observed. From this study, it can be concluded that the application of cocaine/adrenaline to the nasal floor is a safe procedure to reduce blood loss during a Le Fort I procedure.