The rotate-plus-shift C-arm trajectory. Part I. Complete data with less than 180° rotation.

PubMed

Ritschl, Ludwig; Kuntz, Jan; Fleischmann, Christof; Kachelrieß, Marc

2016-05-01

In the last decade, C-arm-based cone-beam CT became a widely used modality for intraoperative imaging. Typically a C-arm CT scan is performed using a circular or elliptical trajectory around a region of interest. Therefore, an angular range of at least 180° plus fan angle must be covered to ensure a completely sampled data set. However, mobile C-arms designed with a focus on classical 2D applications like fluoroscopy may be limited to a mechanical rotation range of less than 180° to improve handling and usability. The method proposed in this paper allows for the acquisition of a fully sampled data set with a system limited to a mechanical rotation range of at least 180° minus fan angle using a new trajectory design. This enables CT like 3D imaging with a wide range of C-arm devices which are mainly designed for 2D imaging. The proposed trajectory extends the mechanical rotation range of the C-arm system with two additional linear shifts. Due to the divergent character of the fan-beam geometry, these two shifts lead to an additional angular range of half of the fan angle. Combining one shift at the beginning of the scan followed by a rotation and a second shift, the resulting rotate-plus-shift trajectory enables the acquisition of a completely sampled data set using only 180° minus fan angle of rotation. The shifts can be performed using, e.g., the two orthogonal positioning axes of a fully motorized C-arm system. The trajectory was evaluated in phantom and cadaver examinations using two prototype C-arm systems. The proposed trajectory leads to reconstructions without limited angle artifacts. Compared to the limited angle reconstructions of 180° minus fan angle, image quality increased dramatically. Details in the rotate-plus-shift reconstructions were clearly depicted, whereas they are dominated by artifacts in the limited angle scan. The method proposed here employs 3D imaging using C-arms with less than 180° rotation range adding full 3D functionality to a C-arm device retaining both handling comfort and the usability of 2D imaging. This method has a clear potential for clinical use especially to meet the increasing demand for an intraoperative 3D imaging.

The rotate-plus-shift C-arm trajectory. Part I. Complete data with less than 180° rotation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ritschl, Ludwig; Fleischmann, Christof; Kuntz, Jan, E-mail: j.kuntz@dkfz.de

Purpose: In the last decade, C-arm-based cone-beam CT became a widely used modality for intraoperative imaging. Typically a C-arm CT scan is performed using a circular or elliptical trajectory around a region of interest. Therefore, an angular range of at least 180° plus fan angle must be covered to ensure a completely sampled data set. However, mobile C-arms designed with a focus on classical 2D applications like fluoroscopy may be limited to a mechanical rotation range of less than 180° to improve handling and usability. The method proposed in this paper allows for the acquisition of a fully sampled datamore » set with a system limited to a mechanical rotation range of at least 180° minus fan angle using a new trajectory design. This enables CT like 3D imaging with a wide range of C-arm devices which are mainly designed for 2D imaging. Methods: The proposed trajectory extends the mechanical rotation range of the C-arm system with two additional linear shifts. Due to the divergent character of the fan-beam geometry, these two shifts lead to an additional angular range of half of the fan angle. Combining one shift at the beginning of the scan followed by a rotation and a second shift, the resulting rotate-plus-shift trajectory enables the acquisition of a completely sampled data set using only 180° minus fan angle of rotation. The shifts can be performed using, e.g., the two orthogonal positioning axes of a fully motorized C-arm system. The trajectory was evaluated in phantom and cadaver examinations using two prototype C-arm systems. Results: The proposed trajectory leads to reconstructions without limited angle artifacts. Compared to the limited angle reconstructions of 180° minus fan angle, image quality increased dramatically. Details in the rotate-plus-shift reconstructions were clearly depicted, whereas they are dominated by artifacts in the limited angle scan. Conclusions: The method proposed here employs 3D imaging using C-arms with less than 180° rotation range adding full 3D functionality to a C-arm device retaining both handling comfort and the usability of 2D imaging. This method has a clear potential for clinical use especially to meet the increasing demand for an intraoperative 3D imaging.« less

Experimental investigation of leading-edge thrust at supersonic speeds

NASA Technical Reports Server (NTRS)

Wood, R. M.; Miller, D. S.

1983-01-01

Wings, designed for leading edge thrust at supersonic speeds, were investigated in the Unitary Plan Wind Tunnel at Mach numbers of 1.60, 1.80, 2.00, 2.16, and 2.36. Experimental data were obtained on a uncambered wing which had three interchangeable leading edges that varied from sharp to blunt. The leading edge thrust concept was evaluated. Results from the investigation showed that leading edge flow separation characteristics of all wings tested agree well with theoretical predictions. The experimental data showed that significant changes in wing leading edge bluntness did not affect the zero lift drag of the uncambered wings.

Phyto-enhanced remediation of soil co-contaminated with lead and diesel fuel using biowaste and Dracaena reflexa: A laboratory study.

PubMed

Dadrasnia, Arezoo; Pariatamby, Agamuthu

2016-03-01

In phytoremediation of co-contaminated soil, the simultaneous and efficient remediation of multiple pollutants is a major challenge rather than the removal of pollutants. A laboratory-scale experiment was conducted to investigate the effect of 5% addition of each of three different organic waste amendments (tea leaves, soy cake, and potato skin) to enhance the phytoaccumulation of lead (60 mg kg(-1)) and diesel fuel (25,000 mg kg(-1)) in co-contaminated soil by Dracaena reflexa Lam for a period of 180 day. The highest rate of oil degradation was recorded in co-contaminated soil planted with D. reflexa and amended with soy cake (75%), followed by potato skin (52.8%) and tea leaves (50.6%). Although plants did not accumulate hydrocarbon from the contaminated soil, significant bioaccumulation of lead in the roots and stems of D. reflexa was observed. At the end of 180 days, 16.7 and 9.8 mg kg(-1) of lead in the stems and roots of D. reflexa were recorded, respectively, for the treatment with tea leaves. These findings demonstrate the potential of organic waste amendments in enhancing phytoremediation of oil and bioaccumulation of lead. © The Author(s) 2015.

Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonates.

PubMed

Ladd, Charlotte O; Thrivikraman, K V; Huot, Rebecca L; Plotsky, Paul M

2005-07-01

Burgeoning evidence supports a preeminent role for early- and late-life stressors in the development of physio- and psychopathology. Handling-maternal separation (HMS) in neonatal Long Evans hooded rats leads to stable phenotypes ranging from resilient to vulnerable to later stressor exposure. Handling with 180 min of maternal separation yields a phenotype of stress hyper-responsiveness associated with facilitation of regional CRF neurocircuits and glucocorticoid resistance. This study assessed whether or not prolonged HMS (180 min/day, HMS180) on post-natal days 2-14 sensitizes the adult limbic hypothalamo-pituitary-adrenal (LHPA) axis to chronic variable stress (CS) compared to brief HMS (15 min/day, HMS15). We examined regional mRNA densities of corticotropin-releasing factor (CRF), its receptor CRF1, glucocorticoid receptor (GR), and mineralocorticoid receptor (MR); regional CRF1 and CRF2alpha binding, and pituitary-adrenal responses to an acute air-puff startle (APS) stressor in four groups: HMS15, nonstressed; HMS15, stressed; HMS180, nonstressed; HMS180, stressed. As expected we observed exaggerated pituitary-adrenal responses to APS, increased regional CRF mRNA density, decreased regional CRF1 binding, and decreased cortical GR mRNA density in nonstressed HMS180 vs. HMS15 animals. However, in contrast to our hypothesis, CS decreased pituitary-adrenal reactivity and central amygdala CRF mRNA density in HMS180 rats, while increasing cortical GR mRNA density and CRF1 binding. CS had no effect on the pituitary-adrenal response to APS in HMS15 rats, despite tripling hypothalamic paraventricular CRF mRNA density. The data suggest that many effects of prolonged HMS are reversible in adulthood by CS, while the neuroendocrine adaptations imbued by brief HMS are sufficiently stable to restrain pituitary-adrenal stress responses even following CS.

Unexpected Far-Ultraviolet Photometric Characteristics On Mimas

NASA Astrophysics Data System (ADS)

Royer, E. M.; Hendrix, A. R.

2013-12-01

While infrared and visible are the most common wavelength domains used to investigate planetary surfaces, ultraviolet (UV) data are significant and useful. Here, we present the first far-UV phase curves of Mimas, thus displaying another piece of the Saturnian System puzzle. Our preliminary results shows that, one more time, Mimas surface properties are far from what we was expected. Namely, we observe a leading hemisphere brighter than the trailing hemisphere at some far-UV wavelengths. We used the far-UV channel of the Cassini/UVIS instrument, ranging from 118 to 190 nm. Disk-integrated phase curves for the leading hemisphere and the trailing hemisphere, at 180nm, have been produced. Data points span from 0.5 to 163.5 degrees in phase angle. Mimas displays a leading hemisphere brighter than its trailing hemisphere, when theory and previous Voyager observations at longer wavelengths attest of a brighter trailing hemisphere due to the impact of the E-ring grains on this face of the satellite. Surprisingly, UVIS data show a very bright opposition effect on Mimas leading hemisphere, greater than what is observed on Tethys or Dione leading hemisphere at the same wavelength of 180 nm. Preliminary results of photometric properties modeling seem to indicate an important contribution of the coherent-backscattering process in the opposition surge. Exogenic processes such as bombardment by energetic electrons and/or E-ring grains are discussed to explain this unexpected surface property of Mimas.

Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line.

PubMed

Tsertsvadze, T; Mitskevich, N; Ghirdaladze, D; Porakishvili, N

2015-03-01

Chronic Lymphocytic Leukemia (CLL) presents with clonal expansion and accumulation of CD5+CD19+CD23+ cells in peripheral lymphoid organs and tissues and in bone marrow. CLL is supposedly driven by exogenous and/or endogenous (auto)antigen(s) and there is increasing evidence that CLL cells receive microenvironmental signals which support their growth, survival and expansion in vivo. We have previously shown that powerful signals are received by CLL cells through CD180 orphan toll-like receptor. Additional accessory signals could be generated through FcγRII (CD32), since both are expressed on CLL cells as well as on control B cells. Here we studied correlation of the expression of CD32 and CD180 on CLL cells as well as on MEC1 cell line. Peripheral blood mononuclear cells (PBMC) from CLL patients and age-matched healthy volunteers were separated, stained with appropriate antibodies to CD19, CD32 and CD180 and analysed by flow cytometry. CD32 and CD180 expression on MEC1 cells was studied at different time-points. The data was statistically analysed using the Mann-Whitney non-parametrical test. Our data indicates that expression of CD32 is significantly increased on CLL cells compared to control B cells as well as in long-term MEC1 cell culture. In contrast, CD180 expression on MEC1 cells significantly decreased throughout 0-96h of MEC1 cell culture. We have recently shown that CD180 ligation can redirect sIgM-mediated signaling from pro-survival to pro-apoptotic. This data indicates that a drop in the expression of CD180 on cycling CLL cells might lead to a weakening of this effect and enhance further survival and expansion of CLL cells in proliferative centres of lymphoid tissues. Since MEC1 cells are derived from a CLL patient with mutated IGVH genes (M-CLL) negative correlation between CD180 and CD32 expression on cycling MEC1 cells could be limited to M-CLL.

Analyzing the defect structure of CuO-doped PZT and KNN piezoelectrics from electron paramagnetic resonance.

PubMed

Jakes, Peter; Kungl, Hans; Schierholz, Roland; Eichel, Rüdiger-A

2014-09-01

The defect structure for copper-doped sodium potassium niobate (KNN) ferroelectrics has been analyzed with respect to its defect structure. In particular, the interplay between the mutually compensating dimeric (Cu(Nb)'''-V(O)··) and trimeric (V(O)··-Cu(Nb)'''-V(O)··)· defect complexes with 180° and non-180° domain walls has been analyzed and compared to the effects from (Cu'' - V(O)··)(x)× dipoles in CuO-doped lead zirconate titanate (PZT). Attempts are made to relate the rearrangement of defect complexes to macroscopic electromechanical properties.

Autoantibodies to BP180 associated with bullous pemphigoid release interleukin-6 and interleukin-8 from cultured human keratinocytes.

PubMed

Schmidt, E; Reimer, S; Kruse, N; Jainta, S; Bröcker, E B; Marinkovich, M P; Giudice, G J; Zillikens, D

2000-11-01

Bullous pemphigoid is an inflammatory subepidermal blistering disease that is associated with auto- antibodies to the keratinocyte surface protein, BP180. In addition to the binding of autoantibodies, the infiltration of inflammatory cells is necessary for blister formation. Cytokines, including interleukin-6 and interleukin-8, have been implicated in the disease process of both human and experimental murine bullous pemphigoid. This study was aimed at testing the hypothesis that the binding of anti-BP180 antibodies to their target antigen triggers a signal transduction event that results in the secretion of these pro-inflammatory cytokines. Consistent with this hypothesis, treatment of cultured normal human epidermal keratinocytes with bullous pemphigoid IgG, but not control IgG, led to increased levels of interleukin-6 and interleukin-8, but not interleukin-1alpha, interleukin-1beta, tumor necrosis factor-alpha, interleukin-10, or monocyte chemoattractant protein-1, in the culture medium. This effect was concentration- and time-dependent and was abolished by depleting the bullous pemphigoid IgG of reactivity to two distinct epitopes on the BP180 NC16A domain. Upregulation of interleukin-6 and interleukin-8 was found at both protein and mRNA levels. In addition, bullous pemphigoid IgG did not induce the release of interleukin-6 and interleukin-8 from BP180-deficient keratinocytes obtained from a patient with generalized atrophic benign epidermolysis bullosa. These data indicate that bullous pemphigoid-associated autoantibodies to the human BP180 ectodomain trigger a signal transducing event that leads to expression and secretion of interleukin-6 and interleukin-8 from human keratinocytes.

Effects of prior short multiple-sprint exercises with different intersprint recoveries on the slow component of oxygen uptake during high-intensity exercise.

PubMed

Lanzi, Stefano; Borrani, Fabio; Wolf, Martin; Gojanovic, Boris; Malatesta, Davide

2012-12-01

This study compares the effects of two short multiple-sprint exercise (MSE) (6 × 6 s) sessions with two different recovery durations (30 s or 180 s) on the slow component of oxygen uptake ([Formula: see text]O(2)) during subsequent high-intensity exercise. Ten male subjects performed a 6-min cycling test at 50% of the difference between the gas exchange threshold and [Formula: see text]O(2peak) (Δ50). Then, the subjects performed two MSEs of 6 × 6 s separated by two intersprint recoveries of 30 s (MSE(30)) and 180 s (MSE(180)), followed 10 min later by the Δ50 (Δ50(30) and Δ50(180), respectively). Electromyography (EMG) activities of the vastus medialis and lateralis were measured throughout each exercise bout. During MSE(30), muscle activity (root mean square) increased significantly (p ≤ 0.04), with a significant leftward-shifted median frequency of the power density spectrum (MDF; p ≤ 0.01), whereas MDF was significantly rightward-shifted during MSE(180) (p = 0.02). The mean [Formula: see text]O(2) value was significantly higher in MSE(30) than in MSE(180) (p < 0.001). During Δ50(30), [Formula: see text]O(2) and the deoxygenated hemoglobin ([HHb]) slow components were significantly reduced (-27%, p = 0.02, and -34%, p = 0.003, respectively) compared with Δ50. There were no significant modifications of the [Formula: see text]O(2) slow component in Δ50(180) compared with Δ50 (p = 0.32). The neuromuscular and metabolic adaptations during MSE(30) (preferential activation of type I muscle fibers evidenced by decreased MDF and a greater aerobic metabolism contribution to the required energy demands), but not during MSE(180), may lead to reduced [Formula: see text]O(2) and [HHb] slow components, suggesting an alteration in motor units recruitment profile (i.e., change in the type of muscle fibers recruited) and (or) an improved muscle O(2) delivery during subsequent exercise.

The contribution of 180° domain wall motion to dielectric properties quantified from in situ X-ray diffraction

DOE PAGES

Fancher, C. M.; Brewer, S.; Chung, C. C.; ...

2016-12-27

Here, the contribution of 180° domain wall motion to polarization and dielectric properties of ferroelectric materials has yet to be determined experimentally. In this paper, an approach for estimating the extent of (180°) domain reversal during application of electric fields is presented. We demonstrate this method by determining the contribution of domain reversal to polarization in soft lead zirconate titanate during application of strong electric fields. At the maximum applied field, domain reversal was determined to account for >80% of the measured macroscopic polarization. We also apply the method to quantify the contribution of domain reversal to the weak-field dielectricmore » permittivity of BaTiO 3. The results of this analysis determined that domain reversal accounts for up to ~70% of the macroscopic dielectric permittivity in BaTiO 3. These results demonstrate the predominance of domain reversal to high and low-field dielectric response in ferroelectric polycrystalline materials.« less

The contribution of 180° domain wall motion to dielectric properties quantified from in situ X-ray diffraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fancher, C. M.; Brewer, S.; Chung, C. C.

2017-03-01

The contribution of 180° domain wall motion to polarization and dielectric properties of ferroelectric materials has yet to be determined experimentally. In this paper, an approach for estimating the extent of (180°) domain reversal during application of electric fields is presented. We demonstrate this method by determining the contribution of domain reversal to polarization in soft lead zirconate titanate during application of strong electric fields. At the maximum applied field, domain reversal was determined to account for >80% of the measured macroscopic polarization. We also apply the method to quantify the contribution of domain reversal to the weak-field dielectric permittivitymore » of BaTiO 3. The results of this analysis determined that domain reversal accounts for up to ~70% of the macroscopic dielectric permittivity in BaTiO 3. These results demonstrate the predominance of domain reversal to high and low-field dielectric response in ferroelectric polycrystalline materials.« less

Ambient lead measurements in Cairo, Egypt

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howes, J.E. Jr.; Labib, M.; Samaha, N.

1999-07-01

The Cairo Air Improvement Project (CAIP) has established a network of 36 stations to monitor airborne lead levels in the Greater Cairo Area. Data obtained during the first 4 months of the monitoring program indicates that lead levels in ambient air significantly exceed the Government of Egypt's (GOE) Law Number 4 (1994) limit of 1 {micro} g/m{sup 3} (annual mean) in areas downwind of secondary lead smelters and in heavily trafficked areas. The highest mean and single sampling event lead levels were observed in the heavily industrialized areas of Shoubra el-Kheima and Tebbin. At two sites in Shoubra el-Kheima, meanmore » and maximum lead levels were determined to be approximately 20 {micro} g/m{sup 3} and 79 {micro} g/m{sup 3}, respectively. At three sites located in areas of high motor vehicle traffic in the central part of the city, the mean lead level was about 4 {micro} g/m{sup 3} and the maximum levels ranged from approximately 10 x 20 {micro} g/m{sup 3}. Of the remainder of the sites, the mean lead concentrations were 2fd3 {micro} g/m{sup 3} at three sites, 1 P2 {mu} g/m{sup 3} at 16 sites, and below 1 {micro} g/m{sup 3} at eight sites. Lead levels in areas devoted primarily to residential use were generally less than 2 {micro} g/m{sup 3}. The maximum mean monthly PM{sub 10} lead value measured at fugitive emission monitoring sites near lead smelters was approximately 73 {micro} g/m{sup 3}. The maximum lead concentration measured during a single sampling event was 180 {micro} g/m{sup 3}. Generally lower lead levels were observed in December due to regulation action that resulted in some suspension of smelting operations and to approximately 180-degree wind direction shifts that typically occur during this period of the year. The GOE is working vigorously to eliminate the lead problem in Egypt through implementation of the Lead Exposure Action Plan (LEAP). A major component of LEAP is the Lead Smelter Action Plan (LSAP).« less

Designing ee-Learning Environments: Lessons from an Online Workshop

ERIC Educational Resources Information Center

Godwin, Lindsey; Kaplan, Soren

2008-01-01

Based on their work leading three experiential, online workshops with over 180 participants from around the world, Lindsey Godwin and Soren Kaplan share reflections on designing and conducting successful ee-learning courses. The workshops sought to translate a popular face-to-face seminar in appreciative inquiry, an increasingly popular…

Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Noelle; Department of Obstetrics and Gynecology, The University of Western Ontario; The Lawson Health Research Institute, The University of Western Ontario

While nicotine replacement therapy is assumed to be a safer alternative to smoking during pregnancy, the long-term consequences for the offspring remain elusive. Animal studies now suggest that maternal nicotine exposure during perinatal life leads to a wide range of adverse outcomes for the offspring including increased adiposity. The focus of this study was to investigate if nicotine exposure during pregnancy and lactation leads to alterations in hepatic triglyceride synthesis. Female Wistar rats were randomly assigned to receive daily subcutaneous injections of saline (vehicle) or nicotine bitartrate (1 mg/kg/day) for two weeks prior to mating until weaning. At postnatal daymore » 180 (PND 180), nicotine exposed offspring exhibited significantly elevated levels of circulating and hepatic triglycerides in the male offspring. This was concomitant with increased expression of fatty acid synthase (FAS), the critical hepatic enzyme in de novo triglyceride synthesis. Given that FAS is regulated by the nuclear receptor Liver X receptor (LXRα), we measured LXRα expression in both control and nicotine-exposed offspring. Nicotine exposure during pregnancy and lactation led to an increase in hepatic LXRα protein expression and enriched binding to the putative LXRE element on the FAS promoter in PND 180 male offspring. This was also associated with significantly enhanced acetylation of histone H3 [K9,14] surrounding the FAS promoter, a hallmark of chromatin activation. Collectively, these findings suggest that nicotine exposure during pregnancy and lactation leads to an increase in circulating and hepatic triglycerides long-term via changes in the transcriptional and epigenetic regulation of the hepatic lipogenic pathway. - Highlights: • Our data reveals the links nicotine exposure in utero and long-term hypertriglyceridemia. • It is due to nicotine-induced augmented expression of hepatic FAS and LXRα activity. • Moreover, this involves nicotine-induced enhanced acetylation of histone H3 [K9,14]. • This provides a mechanism for developmental origins of health and disease (DOHaD)« less

Natural Products as a Source of Alzheimer’s Drug Leads

PubMed Central

Sorribas, Analia; Howes, Melanie-Jayne R.

2016-01-01

This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer’s disease. Compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than 180 compounds and summarizes 393 references. PMID:21072430

Flight investigation of insect contamination and its alleviation

NASA Technical Reports Server (NTRS)

Peterson, J. B., Jr.; Fisher, D. F.

1978-01-01

An investigation of leading edge contamination by insects was conducted with a JetStar airplane instrumented to detect transition on the outboard leading edge flap and equipped with a system to spray the leading edge in flight. The results of airline type flights with the JetStar indicated that insects can contaminate the leading edge during takeoff and climbout. The results also showed that the insects collected on the leading edges at 180 knots did not erode at cruise conditions for a laminar flow control airplane and caused premature transition of the laminar boundary layer. None of the superslick and hydrophobic surfaces tested showed any significant advantages in alleviating the insect contamination problem. While there may be other solutions to the insect contamination problem, the results of these tests with a spray system showed that a continouous water spray while encountering the insects is effective in preventing insect contamination of the leading edges.

The spectrum of resistance in SR/CR mice: the critical role of chemoattraction in the cancer/leukocyte interaction.

PubMed

Riedlinger, Gregory; Adams, Jonathan; Stehle, John R; Blanks, Michael J; Sanders, Anne M; Hicks, Amy M; Willingham, Mark C; Cui, Zheng

2010-05-03

Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. In this study, we challenged SR/CR mice with additional lethal transplantable mouse cancer cell lines to determine their resistance spectrum. The ability of these transplantable cancer cell lines to induce leukocyte infiltration was quantified and the percentage of different populations of responding immune cells was determined using flow cytometry. In comparison to wild type (WT) mice, SR/CR mice showed significantly higher resistance to all cancer cell lines tested. However, SR/CR mice were more sensitive to MethA sarcoma (MethA), B16 melanoma (B16), LL/2 lung carcinoma (LL/2) and J774 lymphoma (J774) than to sarcoma 180 (S180) and EL-4 lymphoma (EL-4). Further mechanistic studies revealed that this lower resistance to MethA and LL/2 was due to the inability of these cancer cells to attract SR/CR leukocytes, leading to tumor cell escape from resistance mechanism. This escape mechanism was overcome by co-injection with S180, which could attract SR/CR leukocytes allowing the mice to resist higher doses of MethA and LL/2. S180-induced cell-free ascites fluid (CFAF) co-injection recapitulated the results obtained with live S180 cells, suggesting that this chemoattraction by cancer cells is mediated by diffusible molecules. We also tested for the first time whether SR/CR mice were able to resist additional cancer cell lines prior to S180 exposure. We found that SR/CR mice had an innate resistance against EL-4 and J774. Our results suggest that the cancer resistance in SR/CR mice is based on at least two separate processes: leukocyte migration/infiltration to the site of cancer cells and recognition of common surface properties on cancer cells. The infiltration of SR/CR leukocytes was based on both the innate ability of leukocytes to respond to chemotactic signals produced by cancer cells and on whether cancer cells produced these chemotactic signals. We found that some cancer cells could escape from SR/CR resistance because they did not induce infiltration of SR/CR leukocytes. However, if infiltration of leukocytes was induced by co-injection with chemotactic factors, these same cancer cells could be effectively recognized and killed by SR/CR leukocytes.

75 FR 5690 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A. Model P-180 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... operator reported a short circuit between a generator power cable and an anti-ice shutoff valve, which was... the damage. If left uncorrected, this situation could lead to short circuits with possible fire and/or... products. The MCAI states: An operator reported a short circuit between a generator power cable and an anti...

Leading by Following: An Analysis of How K-12 School Leaders Use Twitter

ERIC Educational Resources Information Center

Sauers, Nicholas J.; Richardson, Jayson W.

2015-01-01

This study analyzed how active Twitter users who are also school leaders used the tool. The researchers collaboratively identified K-12 school leaders who were active on Twitter and then collected tweets from those school leaders. The final sample for this study included 115 Twitter users and over 180,000 tweets from those individuals. The results…

40 CFR 421.92 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... CATEGORY Metallurgical Acid Plants Subcategory § 421.92 Effluent limitations guidelines representing the...): Subpart I—Metallurgical Acid Plant Pollutant or pollutant property BPT effluent limitations Maximum for... Cadmium 0.180 0.090 Copper 5.000 2.000 Lead 1.800 0.790 Zinc 3.600 0.900 Fluoride 1 212.800 121.000...

40 CFR 421.92 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... CATEGORY Metallurgical Acid Plants Subcategory § 421.92 Effluent limitations guidelines representing the...): Subpart I—Metallurgical Acid Plant Pollutant or pollutant property BPT effluent limitations Maximum for... Cadmium 0.180 0.090 Copper 5.000 2.000 Lead 1.800 0.790 Zinc 3.600 0.900 Fluoride 1 212.800 121.000...

Genetic and physical fine mapping of the novel brown midrib gene bm6 in maize to a 180 kb region on chromosome 2

USDA-ARS?s Scientific Manuscript database

Brown midrib mutants in maize are known to be associated with reduced lignin content and increased cell wall digestibility, which leads to better forage quality and higher efficiency of cellulosic biomass conversion into ethanol. Four well known brown midrib mutants, named bm1-4, were identified sev...

Growth hormone receptor gene mutations in two Italian patients with Laron Syndrome.

PubMed

Fassone, L; Corneli, G; Bellone, S; Camacho-Hübner, C; Aimaretti, G; Cappa, M; Ubertini, G; Bona, G

2007-05-01

Laron Syndrome (LS) represents a condition characterized by GH insensitivity caused by molecular defects in the GH receptor (GHR) gene or in the post-receptor signalling pathway. We report the molecular characterization of two unrelated Italian girls from Sicily diagnosed with LS. The DNA sequencing of the GHR gene revealed the presence of different nonsense mutations, occurring in the same background haplotype. The molecular defects occurred in the extracellular domain of the GHR leading to a premature termination signal and to a truncated non-functional receptor. In one patient, a homozygous G to T transversion, in exon 6, led to the mutation GAA to TAA at codon 180 (E180X), while in the second patient a homozygous C to T transition in exon 7 was detected, causing the CGA to TAA substitution at codon 217 (R217X). Both probands presented the polymorphisms Gly168Gly and Ile544Leu in a homozygous state in exons 6 and 10, respectively. The E180X represents a novel defect of the GHR gene, while the R217X mutation has been previously reported in several patients from different ethnic backgrounds but all from countries located in the Mediterranean and Middle Eastern region.

Growth responses of male broilers subjected to increasing air velocities at high ambient temperatures and a high dew point.

PubMed

Dozier, W A; Lott, B D; Branton, S L

2005-06-01

This study examined live performance responses of male broilers to increasing air velocity of 120 and 180 m/min reared under high cyclic temperatures (25-35-25 degrees C) with a 23 degrees C dew point from 21 to 49 d. Birds were reared in an environmental facility containing 2 wind tunnels (4 pens/tunnel) and 6 floor pens (control). At 21 d, 53 birds were placed in each pen of the wind tunnels and control group, respectively, and growth performance was determined weekly. Increasing air velocity from 120 to 180 m/min improved BW and BW gain from 29 to 35, 36 to 42, and 43 to 49 d of age leading to a cumulative advantage of 287 g in BW gain and a 10-point difference in feed conversion from 21 to 49 d of age. Subjecting birds to air velocity improved growth rate, feed consumption, and feed conversion at each weekly interval from 28 to 49 d over the control birds. These results indicate that male broilers approximating 2.0 to 3.0 kg respond to an air velocity of 180 m/min when exposed to high cyclic temperatures.

Using Molecular Models To Show Steric Clash in Peptides: An Illustration of Two Disallowed Regions in the Ramachandran Diagram

ERIC Educational Resources Information Center

Halkides, Christopher J.

2013-01-01

In this activity, students manipulate three-dimensional molecular models of the Ala-Ala-Ala tripeptide, where Ala is alanine. They rotate bonds to show that the pairs of dihedral angles phi = 0 degrees, psi = 180 degrees, and phi = 0 degrees, psi = 0 degrees lead to unfavorable interactions among the main chain atoms of the tripeptide. This…

75 FR 63060 - Airworthiness Directives; PIAGGIO AERO INDUSTRIES S.p.A. Model PIAGGIO P-180 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

... failure of engine oil dipsticks, installed on Pratt & Whitney Canada (P&WC) PT6A66 and PT6A66B engines... subsequent corrosion, can cause incorrect reading of the engine oil low level on the Refuel/Ground Test Panel. If left uncorrected, this situation could lead to in-flight engine failure(s). We are issuing this AD...

40 CFR 180.388-180.389 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false [Reserved] 180.388-180.389 Section 180.388-180.389 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances §§ 180.388-180.389...

40 CFR 180.388-180.389 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false [Reserved] 180.388-180.389 Section 180.388-180.389 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances §§ 180.388-180.389...

High-speed bipolar phototransistors in a 180 nm CMOS process.

PubMed

Kostov, P; Gaberl, W; Zimmermann, H

2013-03-01

Several high-speed pnp phototransistors built in a standard 180 nm CMOS process are presented. The phototransistors were implemented in sizes of 40×40 μm 2 and 100×100 μm 2 . Different base and emitter areas lead to different characteristics of the phototransistors. As starting material a p + wafer with a p - epitaxial layer on top was used. The phototransistors were optically characterized at wavelengths of 410, 675 and 850 nm. Bandwidths up to 92 MHz and dynamic responsivities up to 2.95 A/W were achieved. Evaluating the results, we can say that the presented phototransistors are well suited for high speed photosensitive optical applications where inherent amplification is needed. Further on, the standard silicon CMOS implementation opens the possibility for cheap integration of integrated optoelectronic circuits. Possible applications for the presented phototransistors are low cost high speed image sensors, opto-couplers, etc.

Dynamic aspects of apparent attenuation and wave localization in layered media

USGS Publications Warehouse

Haney, M.M.; Van Wijk, K.

2008-01-01

We present a theory for multiply-scattered waves in layered media which takes into account wave interference. The inclusion of interference in the theory leads to a new description of the phenomenon of wave localization and its impact on the apparent attenuation of seismic waves. We use the theory to estimate the localization length at a CO2 sequestration site in New Mexico at sonic frequencies (2 kHz) by performing numerical simulations with a model taken from well logs. Near this frequency, we find a localization length of roughly 180 m, leading to a localization-induced quality factor Q of 360.

14 CFR Appendix D to Part 125 - Airplane Flight Recorder Specification

Code of Federal Regulations, 2010 CFR

2010-01-01

...°. Roll Attitude ±180° ±2° 1 0.5°. Radio Transmitter Keying On-Off (Discrete) 1 Thrust/Power on Each... discrete position ±3° or as pilot's Indicator 0.5 0.5% 2 Leading Edge Flap or Cockpit Control Selection Full range or each discrete position ±3° or as pilot's indicator 0.5 0.5% 2 Thrust Reverser Position...

14 CFR Appendix D to Part 135 - Airplane Flight Recorder Specification

Code of Federal Regulations, 2010 CFR

2010-01-01

...° Roll Attitude ±180° ±2° 1 0.5°. Radio Transmitter Keying On-Off (Discrete) 1 Thrust/Power on Each... range or each discrete position ±3° or as pilot's indicator 0.5 0.5% 2. Leading Edge Flap on or Cockpit Control Selection Full range or each discrete position ±3° or as pilot's indicator 0.5 0.5% 2. Thrust...

The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury

PubMed Central

Fang, Hui; Zhang, Yang; Li, Ning; Wang, Gang; Liu, Zhi

2018-01-01

Bullous pemphigoid (BP) is an autoimmune and inflammatory skin disease associated with subepidermal blistering and autoantibodies directed against the hemidesmosomal components BP180 and BP230. Animal models of BP were developed by passively transferring anti-BP180 IgG into mice, which recapitulates the key features of human BP. By using these in vivo model systems, key cellular and molecular events leading to the BP disease phenotype are identified, including binding of pathogenic IgG to its target, complement activation of the classical pathway, mast cell degranulation, and infiltration and activation of neutrophils. Proteinases released by infiltrating neutrophils cleave BP180 and other hemidesmosome-associated proteins, causing DEJ separation. Mast cells and mast cell-derived mediators including inflammatory cytokines and proteases are increased in lesional skin and blister fluids of BP. BP animal model evidence also implicates mast cells in the pathogenesis of BP. However, recent studies questioned the pathogenic role of mast cells in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and epidermolysis bullosa acquisita. This review highlights the current knowledge on BP pathophysiology with a focus on a potential role for mast cells in BP and mast cell-related critical issues needing to be addressed in the future. PMID:29545809

Impact of Autologous Stem Cell Transplantation on Blood Pressure and Renal Function in Multiple Myeloma Patients.

PubMed

Balsam, Leah; Saad, Chadi; Arsene, Camelia; Fogel, Joshua

2017-01-01

Autologous stem cell transplantation (ASCT) reverses kidney failure in one-third of multiple myeloma (MM) patients, which may lead to blood pressure (BP) improvement. We evaluate the long term impact of ASCT on BP and renal function in MM patients. We studied 192 MM patients that underwent ASCT. We compared BP readings and glomerular filtration rate (GFR) at 4 weeks before ASCT, on day of ASCT and post-ASCT at 30, 100 and 180 days. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) on day of ASCT and at both 30 and 100 days post-ASCT was significantly lower as compared to pre-ASCT SBP and DBP. There was a significantly higher mean GFR at day of ASCT and 30 days post-ASCT and significantly lower mean GFR at 180 days post-ASCT as compared to pre-ASCT. White patients had similar patterns to the total group for SBP, DBP, and GFR except for SBP which was still significantly lower and GFR which was not significantly different at 180 days. African-American patients showed no significant reductions in the mean values of SBP and DBP and no significant increases for GFR in follow-up after day of ASCT. Furthermore, the mean value of GFR was significantly lower at 180 days post-ASCT. ASCT in MM patients had a positive impact on SBP and DBP and GFR but the impact was minimal for African-American patients. We recommend that clinicians consider closer follow-up of BP and kidney function and more intense therapy in African-Americans with MM. Copyright © 2017 National Medical Association. Published by Elsevier Inc. All rights reserved.

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21

PubMed Central

Lee, Hyemin; Dai, Fangyan; Zhuang, Li; Xiao, Zhen-Dong; Kim, Jongchan; Zhang, Yilei; Ma, Li; You, M. James; Wang, Zhong; Gan, Boyi

2016-01-01

BAF180 (also called PBRM1), a subunit of the SWI/SNF complex, plays critical roles in the regulation of chromatin remodeling and gene transcription, and is frequently mutated in several human cancers. However, the role of mammalian BAF180 in tumor suppression and tissue maintenance in vivo remains largely unknown. Here, using a conditional somatic knockout approach, we explored the cellular and organismal functions of BAF180 in mouse. BAF180 deletion in primary mouse embryonic fibroblasts (MEFs) triggers profound cell cycle arrest, premature cellular senescence, without affecting DNA damage response or chromosomal integrity. While somatic deletion of BAF180 in adult mice does not provoke tumor development, BAF180 deficient mice exhibit defects in hematopoietic system characterized by progressive reduction of hematopoietic stem cells (HSCs), defective long-term repopulating potential, and hematopoietic lineage developmental aberrations. BAF180 deletion results in elevated p21 expression in both MEFs and HSCs. Mechanistically, we showed that BAF180 binds to p21 promoter, and BAF180 deletion enhances the binding of modified histones associated with transcriptional activation on p21 promoter. Deletion of p21 rescues cell cycle arrest and premature senescence in BAF180 deficient MEFs, and partially rescues hematopoietic defects in BAF180 deficient mice. Together, our study identifies BAF180 as a critical regulator of cellular senescence and HSC homeostasis, which is at least partially regulated through BAF180-mediated suppression of p21 expression. Our results also suggest that senescence triggered by BAF180 inactivation may serve as a failsafe mechanism to restrain BAF180 deficiency-associated tumor development, providing a conceptual framework to further understand BAF180 function in tumor biology. PMID:26992241

Comparison of Theoretical and Experimental Unsteady Aerodynamics of Linear Oscillating Cascade With Supersonic Leading-Edge Locus

NASA Technical Reports Server (NTRS)

Ramsey, John K.; Erwin, Dan

2004-01-01

An experimental influence coefficient technique was used to obtain unsteady aerodynamic influence coefficients and, consequently, unsteady pressures for a cascade of symmetric airfoils oscillating in pitch about mid-chord. Stagger angles of 0 deg and 10 deg were investigated for a cascade with a gap-to-chord ratio of 0.417 operating at an axial Mach number of 1.9, resulting in a supersonic leading-edge locus. Reduced frequencies ranged from 0.056 to 0.2. The influence coefficients obtained determine the unsteady pressures for any interblade phase angle. The unsteady pressures were compared with those predicted by several algorithms for interblade phase angles of 0 deg and 180 deg.

Spiral blood flows in an idealized 180-degree curved artery model

NASA Astrophysics Data System (ADS)

Bulusu, Kartik V.; Kulkarni, Varun; Plesniak, Michael W.

2017-11-01

Understanding of cardiovascular flows has been greatly advanced by the Magnetic Resonance Velocimetry (MRV) technique and its potential for three-dimensional velocity encoding in regions of anatomic interest. The MRV experiments were performed on a 180-degree curved artery model using a Newtonian blood analog fluid at the Richard M. Lucas Center at Stanford University employing a 3 Tesla General Electric (Discovery 750 MRI system) whole body scanner with an eight-channel cardiac coil. Analysis in two regions of the model-artery was performed for flow with Womersley number=4.2. In the entrance region (or straight-inlet pipe) the unsteady pressure drop per unit length, in-plane vorticity and wall shear stress for the pulsatile, carotid artery-based flow rate waveform were calculated. Along the 180-degree curved pipe (curvature ratio =1/7) the near-wall vorticity and the stretching of the particle paths in the vorticity field are visualized. The resultant flow behavior in the idealized curved artery model is associated with parameters such as Dean number and Womersley number. Additionally, using length scales corresponding to the axial and secondary flow we attempt to understand the mechanisms leading to the formation of various structures observed during the pulsatile flow cycle. Supported by GW Center for Biomimetics and Bioinspired Engineering (COBRE), MRV measurements in collaboration with Prof. John K. Eaton and, Dr. Chris Elkins at Stanford University.

The State of Wiki Usage in U.S. K-12 Schools: Leveraging Web 2.0 Data Warehouses to Study Quality and Equality in Online Learning Environments

ERIC Educational Resources Information Center

Reich, Blair Justin Fire

2012-01-01

In the first part of this dissertation, I document wiki usage in U.S. K-12 settings by analyzing data on a representative sample drawn from a population of nearly 180,000 wikis. My research group, which I lead and managed, measured the opportunities wikis provide for students to develop 21st century skills such as expert thinking, complex…

Intramolecular and Lattice Dynamics in V6-nIVVnV O7(OCH3)12 Crystal

NASA Astrophysics Data System (ADS)

Yablokov, Yu. V.; Augustyniak-Jabłokow, M. A.; Borshch, S.; Daniel, C.; Hartl, H.

2006-08-01

Multi-nuclear mixed-valence clusters V4IVV2VO7(OCH3)12 were studied by X-band EPR in the temperature range 4.2-300 K. An isotropic exchange interactions between four VIV ions with individual spin Si=1/2 determine the energy levels structure of the compound with the total spin states S=0, 1, and 2, which are doubled and split due to the extra electron transfer. The spin-Hamiltonian approach was used for the analysis of the temperature dependences of the EPR spectra parameters and the cluster dynamics. Two types of the electron transfer are assumed: the single jump transfer leading to the splitting of the total spin states by intervals comparable in magnitude with the exchange parameter J≈100-150cm-1 and the double jump one resulting in dynamics. The dependence of the transition ratesνtr on the energy of the total spin states was observed. In particular, in the range 300-220 K the νtr ≈0.7×1010 cm-1 and below 180 K the νtr≈1×1010 cm-1 was estimated. The g-factors of the spin states were shown to depend on the values of the intermediate spins. A phase transition in the T-range 210-180 K leading to the change in the initial VIV ions localization was discovered.

Preparation of High Purity Crystalline Silicon by Electro-Catalytic Reduction of Sodium Hexafluorosilicate with Sodium below 180°C

PubMed Central

Chen, Yuan; Liu, Yang; Wang, Xin; Li, Kai; Chen, Pu

2014-01-01

The growing field of silicon solar cells requires a substantial reduction in the cost of semiconductor grade silicon, which has been mainly produced by the rod-based Siemens method. Because silicon can react with almost all of the elements and form a number of alloys at high temperatures, it is highly desired to obtain high purity crystalline silicon at relatively low temperatures through low cost process. Here we report a fast, complete and inexpensive reduction method for converting sodium hexafluorosilicate into silicon at a relatively low reaction temperature (∼200°C). This temperature could be further decreased to less than 180°C in combination with an electrochemical approach. The residue sodium fluoride is dissolved away by pure water and hydrochloric acid solution in later purifying processes below 15°C. High purity silicon in particle form can be obtained. The relative simplicity of this method might lead to a low cost process in producing high purity silicon. PMID:25153509

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitra, Arijit; Barick, Barun; Sharma, H.

We have observed large tunneling Magnetoresistance (TMR) in amine functionalized octahedral nanoparticle assemblies. Amine monolayer on the surface of nanoparticles acts as an insulating barrier between the semimetal Fe{sub 3}O{sub 4} nanoparticles and provides multiple tunnel junctions where inter-granular tunneling is plausible. The tunneling magnetoresistance recorded at room temperature is 38% which increases to 69% at 180 K. When the temperature drops below 150 K, coulomb staircase is observed in the current versus voltage characteristics as the charging energy exceeds the thermal energy. A similar study is also carried out with spherical nanoparticles. A 24% TMR is recorded at roommore » temperature which increases to 41% at 180 K for spherical particles. Mössbauer spectra reveal better stoichiometry for octahedral particles which is attainable due to lesser surface disorder and strong amine coupling at the <111> facets of octahedral Fe{sub 3}O{sub 4} nanoparticles. Less stoichiometric defect in octahedral nanoparticles leads to a higher value of spin polarization and therefore larger TMR in octahedral nanoparticles.« less

[A case of ring melanoma found while treating traumatic glaucoma].

PubMed

Manabe, Kazuyo; Jo, Nobuo; Tateno, Hiroko; Shishidon, Nami; Takahashi, Kanji; Iwashita, Kenshiro; Isei, Taiki; Ohe, Chisato; Sakaida, Noriko; Uemura, Yoshiko

2013-04-01

Ring melanoma, a malignant melanoma which infiltrates over 180 degrees degrees of the ciliary body is very rare in Japan. We report a case of ring melanoma found while treating treatment of traumatic glaucoma with an ultrasound biomicroscope (UBM). A 44-year old woman presented with high intraocular pressure after blunt trauma in her left eye. Best-corrected visual acuity OS was 1.2, and intraocular pressure was 30 mmHg. Gonioscopy showed about 180 degrees of the angle recession. Intraocular pressure was difficult to control in spite of anti-glaucoma drug treatment. Rapid progression of iris elevation and 360 degrees thickening of the ciliary body were detected by UBM. We detected atypical cells with melanine granules in the aqueous fluid and positive findings in PET-CT, leading to a diagnosis of ciliary body malignant melanoma. Consequently we enucleated the left eye. The histopathological diagnosis was ring melanoma. Ring melanoma is an important element in the differential diagnosis for untreatable secondary glaucoma.

46 CFR 180.200 - Survival craft-general.

Code of Federal Regulations, 2010 CFR

2010-10-01

... on the Great Lakes—§ 180.206(b). 6 Shallow water exception—§ 180.207(e). 7 OCMI may reduce survival...) and § 180.208(e) 8 Shallow water exception—§ 180.208(e)C. [CGD 85-080, 61 FR 975, Jan. 10, 1996, as...

Long-Lead Prediction of the 2015 Fire and Haze Episode in Indonesia

NASA Astrophysics Data System (ADS)

Shawki, Dilshad; Field, Robert D.; Tippett, Michael K.; Saharjo, Bambang Hero; Albar, Israr; Atmoko, Dwi; Voulgarakis, Apostolos

2017-10-01

We conducted a case study of National Centers for Environmental Prediction Climate Forecast System version 2 seasonal model forecast performance over Indonesia in predicting the dry conditions in 2015 that led to severe fire, in comparison to the non-El Niño dry season conditions of 2016. Forecasts of the Drought Code (DC) component of Indonesia's Fire Danger Rating System were examined across the entire equatorial Asia region and for the primary burning regions within it. Our results show that early warning lead times of high observed DC in September and October 2015 varied considerably for different regions. High DC over Southern Kalimantan and Southern New Guinea were predicted with 180 day lead times, whereas Southern Sumatra had lead times of up to only 60 days, which we attribute to the absence in the forecasts of an eastward decrease in Indian Ocean sea surface temperatures. This case study provides the starting point for longer-term evaluation of seasonal fire danger rating forecasts over Indonesia.

Effect of a 188 Re-SSS lipiodol/131I-lipiodol mixture, 188 Re-SSS lipiodol alone or 131I-lipiodol alone on the survival of rats with hepatocellular carcinoma.

PubMed

Garin, Elienne; Rakotonirina, Hervé; Lejeune, Florence; Denizot, Benoit; Roux, Jerome; Noiret, Nicolas; Mesbah, Habiba; Herry, Jean-Yues; Bourguet, Patrick; Lejeune, Jean-Jacques

2006-04-01

It has been shown that the use of a cocktail of isotopes of different ranges of action leads to an increase in the effectiveness of metabolic radiotherapy. The purpose of the present study was to compare with a control group the effectiveness of three different treatments in rats bearing hepatocellular carcinoma (HCC), using (1) a mixture of lipiodol labelled with both I and Re, (2) lipiodol labelled with I alone and (3) lipiodol labelled with Re alone. Four groups were made up, each containing 14 rats with the N1-S1 tumour cell line. Group 1 received a mixture composed of 22 MBq of Re-SSS lipiodol and 7 MBq I-lipiodol. Group 2 received 14 MBq I-lipiodol. Group 3 received 44 MBq of Re-SSS lipiodol and group 4 acted as the control. The survival of the various groups was compared by a non-parametric test of log-rank, after a follow-up of 60, 180 and 273 days. Compared with the controls, the rats treated with a mixture of Re-SSS lipiodol and I-lipiodol show an increase in survival, but only from day 60 onwards (P=0.05 at day 60 and 0.13 at days 180 and 273). For the rats treated with I-lipiodol, there was a highly significant increase in survival compared with the controls at day 60, day 180 and day 273 (P=0.03, 0.04 and 0.04, respectively). There is no significant increase in survival for the rats treated with Re-SSS lipiodol, irrespective of the follow-up duration (P=0.53 at day 60, 0.48 at day 180, and 0.59 at day 273). In this study, I-lipiodol is the most effective treatment in HCC-bearing rats, because this is the only method that leads to a prolonged improvement of survival. These results cannot necessarily be extrapolated to humans because of the relatively small size and unifocal nature of the lesions in this study. It appears necessary to carry out a study in humans with larger tumours in order to compare these three treatments, particularly with a view to replacing I-labelled lipiodol by Re-labelled lipiodol. However, this study clearly demonstrated that, for small tumours, as in an adjuvant setting for example, I-labelled lipiodol should be a better option than Re-labelled lipiodol.

Stagnation Region Heat Transfer: The Influence of Turbulence Parameters, Reynolds Number and Body Shape

NASA Technical Reports Server (NTRS)

Vanfossen, G. James; Simoneau, Robert J.

1994-01-01

The effect of velocity gradient on stagnation region heat transfer augmentation by free stream turbulence was investigated. Heat transfer was measured in the stagnation region of four models with elliptical leading edges with ratios of major to minor axes of 1:1, 1.5:1, 2.25:1, and 3:1. Four geometrically similar, square bar, square mesh, biplane grids were used to generate free stream turbulence with different intensities and length. Heat transfer measurements were made for the following ranges of parameters: Reynolds number, based on leading edge diameter, 37,000 to 228,000; dimensionless leading edge velocity gradient, 1.20 to 1.80; turbulence intensity, 1.1 to 15.9%; and length scale to leading edge diameter ratio, 0.05 to 0.30. Stagnation point heat transfer augmentation by free stream turbulence can be predicted using a modified version of a previously developed correlation for a circular leading edge. Heat transfer augmentation was independent of body shape at the stagnation point. The heat transfer distribution down-stream from the stagnation point can be predicted using the normalized laminar heat transfer distribution.

Optimal Constellation Design for Maximum Continuous Coverage of Targets Against a Space Background

DTIC Science & Technology

2012-05-31

constellation is considered with the properties shown in Table 13. The parameter hres refers to the number of equally spaced offset planes in which cross...mean anomaly 180 ◦ M0i mean anomaly of lead satellite at epoch 0 ◦ R omni-directional sensor range 5000 km m initial polygon resolution 50 PPC hres ...a Walker Star. Idealized parameters for the Iridium constellation are shown in Table 14. The parameter hres refers to the number of equally spaced

Distribution of Endo180 receptor and ligand in developing articular cartilage.

PubMed

Howard, M J; Chambers, M G; Mason, R M; Isacke, C M

2004-01-01

To investigate the expression of a novel member of the mannose receptor family, Endo180 (also known as uPARAP), and the distribution of Endo180 ligand(s) in the articular cartilage and growth plate of normal CBA mice and STR/ort mice, a well characterized model of spontaneous osteoarthritis. A polyclonal anti-Endo180 antibody was used to determine receptor expression. The Endo180 extracellular domain fused to a human immunoglobulin Fc tail was used to detect ligand. Endo180 receptor was strongly expressed in chondrocytes both in vitro and throughout the articular cartilage of young CBA and STR/ort mice. Expression decreased in older animals. In STR/ort mice with osteoarthritic lesions, no upregulation of Endo180 was detected. In the developing growth plate, Endo180 was expressed strongly by the proliferating chondrocytes. In contrast, Endo180 ligand was detected most strongly in hypertrophic zone of the growth plate and only at low levels in articular cartilage. In cultured chondrocytes, Endo180 was localized on the cell surface and in intracellular vesicles. Constitutively recycling endocytic receptors function to internalize ligand from the extracellular milieu and the ability of Endo180 to bind both glycosylated ligands and collagens suggests a role in extracellular matrix remodeling. Expression of Endo180 in articular cartilage chondrocytes of young, but not old, mice and the reciprocal expression of Endo180 and its ligands in the growth plate suggest that this receptor is involved in cartilage development but not in cartilage homeostasis. In addition, our data indicates that Endo180 does not appear to play a role in the development or progression of murine osteoarthritis.

Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).

PubMed

Mohan, Jasna Jagan; Narayan, Prashanth; Padmanabhan, Renjini Ambika; Joseph, Selin; Kumar, Pradeep G; Laloraya, Malini

2018-07-01

Dedicator of cytokinesis (DOCK 180) involved in cytoskeletal reorganization is primarily a cytosolic molecule. It is recently shown to be nuclear in HeLa cells but its nuclear function is not known. The spatiotemporal distribution of DOCK180 in uterus was studied in uterine cytoplasmic and nuclear compartments during the "window of implantation." The functional significance of nuclear DOCK180 was explored by homology modeling, co-immunoprecipitation assays, and mass spectrometric analysis. Dock180's role in early pregnancy was ascertained by Dock 180 silencing and subsequent quantitative real-time PCR and Western blotting analysis. Our study shows a nuclear DOCK180 in the uterus during "window of implantation." Estrogen and progesterone mediate expression and nuclear translocation of DOCK180. The nuclear function of DOCK180 is attributed to its ability to import autoimmune regulator (AIRE) into the nucleus. Silencing of Dock180 inhibited AIRE nuclear shuttling which influenced its downstream targets, thereby affecting decidualization with AIRE and HOXA-10 as the major players as well as lack of implantation site formation due to impact on angiogenesis-associated genes. DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Neuronal Activity and the Expression of Clathrin Assembly Protein AP180

PubMed Central

Wu, Fangbai; Mattson, Mark P.; Yao, Pamela J.

2010-01-01

The clathrin assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity. PMID:20937255

Comparison of lead removal behaviors and generation of water-soluble sodium compounds in molten lead glass under a reductive atmosphere

NASA Astrophysics Data System (ADS)

Okada, Takashi; Nishimura, Fumihiro; Xu, Zhanglian; Yonezawa, Susumu

2018-06-01

We propose a method of reduction-melting at 1000 °C, using a sodium-based flux, to recover lead from cathode-ray tube funnel glass. To recover the added sodium from the treated glass, we combined a reduction-melting process with a subsequent annealing step at 700 °C, generating water-soluble sodium compounds in the molten glass. Using this combined process, this study compares lead removal behavior and the generation of water-soluble sodium compounds (sodium silicates and carbonates) in order to gain fundamental information to enhance the recovery of both lead and sodium. We find that lead removal increases with increasing melting time, whereas the generation efficiency of water-soluble sodium increases and decreases periodically. In particular, near 90% lead removal, the generation of water-soluble sodium compounds decreased sharply, increasing again with the prolongation of melting time. This is due to the different crystallization and phase separation efficiencies of water-soluble sodium in molten glass, whose structure continuously changes with lead removal. Previous studies used a melting time of 60 min in the processes. However, in this study, we observe that a melting time of 180 min enhances the water-soluble sodium generation efficiency.

Musculoskeletal neck pain in children and adolescents: Risk factors and complications.

PubMed

Fares, Jawad; Fares, Mohamad Y; Fares, Youssef

2017-01-01

Neck pain is a major public health concern that has been extensively studied in adults but not in children and adolescents. Therefore, the purpose of this article is to explore musculoskeletal neck pain in children and adolescents, as well as to discuss its possible risk factors and complications. Participants were patients under 18 years of age, who had presented to the clinic (Beirut, Lebanon) in 2015, with nonspecific neck pain. They were examined and asked to evaluate and localize the pain. Neck positioning during various activities along with other complications were explored. Patients reporting pain associated with congenital or systemic diseases and fractures were excluded. Two-hundred-and-seven children and adolescents presented with nonspecific neck pain. Musculoskeletal neck pain with spasm was diagnosed in 180 patients ( N = 180). Participants did not show any findings on physical examination and radiological studies, and had no comorbidities. More females (57%) than males (43%) and more adolescents (60%) than children (40%) were affected. All the 180 participants (100%) reported flawed flexion of their back and neck while studying and/or using smartphones and tablets. Eye symptoms were reported in 21% of the cases, and parents of most participants (82%) reported a change in the psychological and social behavior of their children. Musculoskeletal neck pain is an important disease in children and adolescents with numerous risk factors contributing to its development. Increased stresses regarding the cervical spine may lead to cervical degeneration along with other developmental, medical, psychological, and social complications.

All-cause mortality in hospitalized patients with infectious diarrhea: Clostridium difficile versus other enteric pathogens in Austria from 2008 to 2010.

PubMed

Schmid, D; Kuo, H W; Simons, E; Kanitz, E E; Wenisch, J; Allerberger, F; Wenisch, C

2014-01-01

Clostridium difficile infection is the leading cause of gastroenteritis-associated deaths in the industrialized world, followed by infection with norovirus. Using a cohort study design, we compared 90 inpatients with diarrhea due to C. difficile infection (CDI) with 180 inpatients with diarrhea due to other infectious agents (including 55% with norovirus infection) with respect to complications and all-cause mortality. The effects of age, severity of underlying diseases and additional infections were assessed by stratified analyses. Diarrhea recurrence occurred 8.9 (95%CI: 2.9-27.3) times more often in CDI independent of age and severity of comorbidities. The all-cause mortality in CDI patients pre-discharge and at 30 and 180 days, respectively, was 20.0%, 17.0% and 42.3% versus 7.2%, 6.7% and 22.5% in non-CDI diarrhea patients. Among those patients with low comorbidities, who were younger than 65 years and without additional infections, the all-cause pre-discharge, 30-day and 180-day mortality risks were significantly higher for the CDI diarrhea patients than the non-CDI diarrhea patients. This association was not observed among patients with an older age, more severe comorbidities or additional infections. CDI results in higher all-cause mortality than diarrhea due to other infectious agents in younger patients with low comorbidities. Copyright © 2013 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

Electric field induced reversible 180° magnetization switching through tuning of interfacial exchange bias along magnetic easy-axis in multiferroic laminates

PubMed Central

Xue, Xu; Zhou, Ziyao; Peng, Bin; Zhu, Mingmin; Zhang, Yijun; Ren, Wei; Ren, Tao; Yang, Xi; Nan, Tianxiang; Sun, Nian X.; Liu, Ming

2015-01-01

E-field control of interfacial exchange coupling and deterministic switching of magnetization have been demonstrated in two sets of ferromagnetic(FM)/antiferromagnetic(AFM)/ferroelectric(FE) multiferroic heterostructures, including NiFe/NiCoO/glass/PZN-PT (011) and NiFe/FeMn/glass/PZN-PT (011). We designed this experiment to achieve exchange bias tuning along the magnetic easy axis, which is critical for realizing reversible 180° magnetization deterministic switching at zero or small magnetic bias. Strong exchange coupling were established across AFM-FM interfaces, which plays an important role in voltage control of magnetization switching. Through the competition between the E-field induced uniaxial anisotropy in ferromagnetic layer and unidirectional anisotropy in antiferromagnetic layer, the exchange bias was significantly shifted by up to |∆Hex|/Hex = 8% in NiFe/FeMn/glass/PZN-PT (011) and 13% in NiFe/NiCoO/glass/PZN-PT (011). In addition, the square shape of the hysteresis loop, as well as a strong shape tunability of |∆Hex|/Hc = 67.5 ~ 125% in NiFe/FeMn/glass/PZN-PT and 30 ~ 38% in NiFe/NiCoO/glass/PZN-PT were achieved, which lead to a near 180° magnetization switching. Electrical tuning of interfacial exchange coupling in FM/AFM/FE systems paves a new way for realizing magnetoelectric random access memories and other memory technologies. PMID:26576658

Electric field induced reversible 180° magnetization switching through tuning of interfacial exchange bias along magnetic easy-axis in multiferroic laminates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, Xu; Zhou, Ziyao; Peng, Bin

2015-11-18

E-field control of interfacial exchange coupling and deterministic switching of magnetization have been demonstrated in two sets of ferromagnetic(FM)/antiferromagnetic(AFM)/ferroelectric(FE) multiferroic heterostructures, including NiFe/NiCoO/glass/PZN-PT (011) and NiFe/FeMn/glass/PZN-PT (011). We designed this experiment to achieve exchange bias tuning along the magnetic easy axis, which is critical for realizing reversible 180° magnetization deterministic switching at zero or small magnetic bias. Strong exchange coupling were established across AFM-FM interfaces, which plays an important role in voltage control of magnetization switching. Through the competition between the E-field induced uniaxial anisotropy in ferromagnetic layer and unidirectional anisotropy in antiferromagnetic layer, the exchange bias was significantly shiftedmore » by up to |ΔH ex|/H ex=8% in NiFe/FeMn/glass/PZN-PT (011) and 13% in NiFe/NiCoO/glass/PZN-PT (011). In addition, the square shape of the hysteresis loop, as well as a strong shape tunability of |ΔH ex|/H c=67.5~125% in NiFe/FeMn/glass/PZN-PT and 30~38% in NiFe/NiCoO/glass/PZN-PT were achieved, which lead to a near 180° magnetization switching. Lastly, electrical tuning of interfacial exchange coupling in FM/AFM/FE systems paves a new way for realizing magnetoelectric random access memories and other memory technologies.« less

Electric field induced reversible 180° magnetization switching through tuning of interfacial exchange bias along magnetic easy-axis in multiferroic laminates

NASA Astrophysics Data System (ADS)

Xue, Xu; Zhou, Ziyao; Peng, Bin; Zhu, Mingmin; Zhang, Yijun; Ren, Wei; Ren, Tao; Yang, Xi; Nan, Tianxiang; Sun, Nian X.; Liu, Ming

2015-11-01

E-field control of interfacial exchange coupling and deterministic switching of magnetization have been demonstrated in two sets of ferromagnetic(FM)/antiferromagnetic(AFM)/ferroelectric(FE) multiferroic heterostructures, including NiFe/NiCoO/glass/PZN-PT (011) and NiFe/FeMn/glass/PZN-PT (011). We designed this experiment to achieve exchange bias tuning along the magnetic easy axis, which is critical for realizing reversible 180° magnetization deterministic switching at zero or small magnetic bias. Strong exchange coupling were established across AFM-FM interfaces, which plays an important role in voltage control of magnetization switching. Through the competition between the E-field induced uniaxial anisotropy in ferromagnetic layer and unidirectional anisotropy in antiferromagnetic layer, the exchange bias was significantly shifted by up to |ΔHex|/Hex = 8% in NiFe/FeMn/glass/PZN-PT (011) and 13% in NiFe/NiCoO/glass/PZN-PT (011). In addition, the square shape of the hysteresis loop, as well as a strong shape tunability of |ΔHex|/Hc = 67.5 ~ 125% in NiFe/FeMn/glass/PZN-PT and 30 ~ 38% in NiFe/NiCoO/glass/PZN-PT were achieved, which lead to a near 180° magnetization switching. Electrical tuning of interfacial exchange coupling in FM/AFM/FE systems paves a new way for realizing magnetoelectric random access memories and other memory technologies.

Electric field induced reversible 180° magnetization switching through tuning of interfacial exchange bias along magnetic easy-axis in multiferroic laminates.

PubMed

Xue, Xu; Zhou, Ziyao; Peng, Bin; Zhu, Mingmin; Zhang, Yijun; Ren, Wei; Ren, Tao; Yang, Xi; Nan, Tianxiang; Sun, Nian X; Liu, Ming

2015-11-18

E-field control of interfacial exchange coupling and deterministic switching of magnetization have been demonstrated in two sets of ferromagnetic(FM)/antiferromagnetic(AFM)/ferroelectric(FE) multiferroic heterostructures, including NiFe/NiCoO/glass/PZN-PT (011) and NiFe/FeMn/glass/PZN-PT (011). We designed this experiment to achieve exchange bias tuning along the magnetic easy axis, which is critical for realizing reversible 180° magnetization deterministic switching at zero or small magnetic bias. Strong exchange coupling were established across AFM-FM interfaces, which plays an important role in voltage control of magnetization switching. Through the competition between the E-field induced uniaxial anisotropy in ferromagnetic layer and unidirectional anisotropy in antiferromagnetic layer, the exchange bias was significantly shifted by up to |∆Hex|/Hex = 8% in NiFe/FeMn/glass/PZN-PT (011) and 13% in NiFe/NiCoO/glass/PZN-PT (011). In addition, the square shape of the hysteresis loop, as well as a strong shape tunability of |∆Hex|/Hc = 67.5 ~ 125% in NiFe/FeMn/glass/PZN-PT and 30 ~ 38% in NiFe/NiCoO/glass/PZN-PT were achieved, which lead to a near 180° magnetization switching. Electrical tuning of interfacial exchange coupling in FM/AFM/FE systems paves a new way for realizing magnetoelectric random access memories and other memory technologies.

The group B streptococcal alpha C protein binds alpha1beta1-integrin through a novel KTD motif that promotes internalization of GBS within human epithelial cells.

PubMed

Bolduc, Gilles R; Madoff, Lawrence C

2007-12-01

Group B Streptococcus (GBS) is the leading cause of bacterial pneumonia, sepsis and meningitis among neonates and a cause of morbidity among pregnant women and immunocompromised adults. GBS epithelial cell invasion is associated with expression of alpha C protein (ACP). Loss of ACP expression results in a decrease in GBS internalization and translocation across human cervical epithelial cells (ME180). Soluble ACP and its 170 amino acid N-terminal region (NtACP), but not the repeat protein RR', bind to ME180 cells and reduce internalization of wild-type GBS to levels obtained with an ACP-deficient isogenic mutant. In the current study, ACP colocalized with alpha(1)beta(1)-integrin, resulting in integrin clustering as determined by laser scanning confocal microscopy. NtACP contains two structural domains, D1 and D2. D1 is structurally similar to fibronectin's integrin-binding region (FnIII10). D1's (KT)D146 motif is structurally similar to the FnIII10 (RG)D1495 integrin-binding motif, suggesting that ACP binds alpha(1)beta(1)-integrin via the D1 domain. The (KT)D146A mutation within soluble NtACP reduced its ability to bind alpha(1)beta(1)-integrin and inhibit GBS internalization within ME180 cells. Thus ACP binding to human epithelial cell integrins appears to contribute to GBS internalization within epithelial cells.

46 CFR 180.200 - Survival craft-general.

Code of Federal Regulations, 2014 CFR

2014-10-01

... in Table 180.200(c). Table 180.200(c) Route Survival craft requirements Oceans (a) cold water 1—100...(b). Coastwise (a) wood vsls in cold water. (i) 67% IBA—§ 180.204(a)(1). (ii) w/subdivision—100% LF... 20 miles from a harbor of safe refuge) (a) wood vsls in cold water.(i) 67% IBA—§ 180.205(a)(1). (ii...

2 CFR 180.340 - If I disclose unfavorable information required under § 180.335, will I be prevented from...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false If I disclose unfavorable information required under § 180.335, will I be prevented from participating in the transaction? 180.340 Section 180.340 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND...

An Investigation of Large Tilt-Rotor Hover and Low Speed Handling Qualities

DTIC Science & Technology

2011-05-01

de (d B) 10 1 100 101 102 360 180 0 180 360 Frequency (rad...sec) Ph as e (d eg ) CAMRAD Reduced order 150 100 50 0 50 M ag ni tu de (d B) 10 1 100 101 102 360 180 0 180 360 Frequency (rad/sec) Ph as e...time specifications defined in ADS-33. Additionally, the 0 10 20 30 40 50 M ag ni tu de (d B) 10 2 10 1 100 101 102 360 180 0 180 360

Cytotoxic T lymphocyte-dependent tumor growth inhibition by a vascular endothelial growth factor-superantigen conjugate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Qingwen; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433; Jiang, Songmin

2012-11-02

Highlights: Black-Right-Pointing-Pointer We construct and purify a fusion protein VEGF-SEA. Black-Right-Pointing-Pointer VEGF-SEA strongly repressed the growth of murine solid sarcoma 180 (S180) tumors. Black-Right-Pointing-Pointer T cells driven by VEGF-SEA were accumulated around tumor cells bearing VEGFR by mice image model. Black-Right-Pointing-Pointer VEGF-SEA can serve as a tumor targeting agent and sequester CTLs into the tumor site. Black-Right-Pointing-Pointer The induced CTLs could release the cytokines, perforins and granzyme B to kill the tumor cells. -- Abstract: T cells are major lymphocytes in the blood and passengers across the tumor vasculature. If these T cells are retained in the tumor site, amore » therapeutic potential will be gained by turning them into tumor-reactive cytotoxic T lymphocytes (CTLs). A fusion protein composed of human vascular endothelial growth factor (VEGF) and staphylococcal enterotoxin A (SEA) with a D227A mutation strongly repressed the growth of murine solid sarcoma 180 (S180) tumors (control versus VEGF-SEA treated with 15 {mu}g, mean tumor weight: 1.128 g versus 0.252 g, difference = 0.876 g). CD4{sup +} and CD8{sup +} T cells driven by VEGF-SEA were accumulated around VEGFR expressing tumor cells and the induced CTLs could release the tumoricidal cytokines, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha). Meanwhile, intratumoral CTLs secreted cytolytic pore-forming perforin and granzyme B proteins around tumor cells, leading to the death of tumor cells. The labeled fusion proteins were gradually targeted to the tumor site in an imaging mice model. These results show that VEGF-SEA can serve as a tumor targeting agent and sequester active infiltrating CTLs into the tumor site to kill tumor cells, and could therefore be a potential therapeutical drug for a variety of cancers.« less

The semantic component of the evoked potential of differentiation.

PubMed

Izmailov, Chingis A; Korshunova, Svetlana G; Sokolov, Yevgeniy N

2008-05-01

This work analyzes data from recordings of (occipital and temporal) cortical evoked potentials (called evoked potentials of differentiation (EPD) occurring in humans in response to an abrupt substitution of stimuli. As stimuli we used three groups of words: the names of the ten basic colors taken from Newton's color circle; the names of seven basic emotions forming Shlossberg's circle of emotions; and seven nonsense words comprised of random combinations of letters. Within each group of word stimuli we constructed a matrix of the differences between the amplitudes of mid-latency components of EPD for each pair of words. This matrix was analyzed using the method of multidimensional scaling. As a result of this analysis we were able to distinguish the semantic and configurational components of EPD amplitude. The semantic component of EPD amplitude was evaluated by comparing structure of the data obtained to the circular structures of emotion and color names. The configurational component was evaluated on the basis of the attribute of word length (number of letters). It was demonstrated that the semantic component of the EPD can only be detected in the left occipital lead at an interpeak amplitude of P120-N180. The configurational component is reflected in the occipital and temporal leads to an identical extent, but only in the amplitude of a later (N180-P230) component of the EPD. The results obtained are discussed in terms of the coding of categorized, configurational, and semantic attributes of a visual stimulus.

50 CFR 660.394 - Latitude/longitude coordinates defining the 180 fm (329 m) through 250 fm (457 m) depth contours.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the 180 fm (329 m) through 250 fm (457 m) depth contours. 660.394 Section 660.394 Wildlife and... Latitude/longitude coordinates defining the 180 fm (329 m) through 250 fm (457 m) depth contours... section provides coordinates for the 180 fm (329 m) through 250 fm (457 m) depth contours. (a) The 180-fm...

Factors affecting ewe performance in a crossbred dairy sheep research flock in the United States.

PubMed

Murphy, T W; Berger, Y M; Holman, P W; Baldin, M; Burgett, R L; Thomas, D L

2017-05-01

The Spooner Agricultural Research Station operated the only dairy sheep research flock in North America through 2016. The original nondairy ewe flock was "bred up" to a crossbred dairy flock through the use of rams and semen of the East Friesian (EF) and Lacaune (LA) dairy breeds. The objective of this study was to determine the environmental and nonadditive genetic effects that influence performance of dairy ewes. The traits analyzed were 180 d adjusted milk (180d MY), fat (180d FY), and protein (180d PY) yields, percentage fat (%F) and protein (%P) in milk, lactation average somatic cell score (LSCS), and number of lambs born per ewe lambing (NLB). The univariate repeatability models included the fixed effects of year of lambing, age, weaning system (except for the trait of NLB), individual breed composition, and individual retained heterosis along with the random additive genetic, permanent environmental, and residual effects. Estimates of heritability were moderate for 180d MY (0.32 ± 0.04), 180d FY (0.26 ± 0.04), and 180d PY (0.29 ± 0.04), high for %F (0.54 ± 0.04) and %P (0.61 ± 0.04), and low for LSCS (0.12 ± 0.03) and NLB (0.08 ± 0.02). Ewes that reared their lambs had lower ( < 0.01) 180d MY, 180d FY, 180d PY, %F, and %P and higher ( < 0.001) LSCS than ewes that had their lambs removed shortly after parturition. Relative to nondairy breeding, EF and LA breeding had positive ( < 0.001) effects on 180d MY, 180d FY, and 180d PY, but a negative ( < 0.03) effect on %P. Purebred EF ewes were predicted to have lower ( < 0.001) %F than purebred LA or nondairy ewes. Purebred LA ewes were predicted to have a higher ( < 0.001) LSCS than purebred EF or nondairy ewes. Purebred EF ewes were expected to be more ( < 0.001) prolific than purebred LA or nondairy ewes. Individual retained heterosis had a favorable ( < 0.01) effect on 180d MY, 180d FY, 180d PY, and NLB. Knowledge of the factors affecting dairy ewe performance are important for dairy sheep producers to make more informed husbandry and breeding decisions.

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet

PubMed Central

McCormack, Thomas J; Melis, Claudio; Colón, José; Gay, Elaine A; Mike, Arpad; Karoly, Robert; Lamb, Patricia W; Molteni, Carla; Yakel, Jerrel L

2010-01-01

The rat α7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the β9 strand. The replacement of this proline residue at position 180 (P180) by either threonine (α7-P180T) or serine (α7-P180S) slowed the onset of desensitization dramatically, with half-times of ∼930 and 700 ms, respectively, compared to 90 ms for the wild-type receptor. To investigate the importance of the hydroxyl group on the position 180 side-chains, the mutant receptors α7-P180Y and α7-P180F were studied and showed half-times of desensitization of 650 and 160 ms, respectively. While a position 180 side-chain OH group may contribute to the slow desensitization rates, α7-P180S and α7-P180V resulted in receptors with similar desensitization rates, suggesting that increased backbone to backbone H bonding expected in the absence of proline at position 180 would likely exert a great effect on desensitization. Single channel recordings indicated that for the α7-P180T receptor there was a significantly reduced closed time without any change in single channel conductance (as compared to wild-type). Kinetic simulations indicated that all changes observed for the mutant channel behaviour were reproduced by decreasing the rate of desensitization, and increasing the microscopic affinity to resting receptors. Molecular dynamics (MD) simulations on a homology model were used to provide insight into likely H bond interactions within the outer β-sheet that occur when the P180 residue is mutated. All mutations analysed increased about twofold the predicted number of H bonds between the residue at position 180 and the backbone of the β10 strand. Moreover, the α7-P180T and α7-P180S mutations also formed some intrastrand H bonds along the β9 strand, although H bonding of the OH groups of the threonine or serine side-chains was predicted to be infrequent. Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand. PMID:20837638

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet.

PubMed

McCormack, Thomas J; Melis, Claudio; Colón, José; Gay, Elaine A; Mike, Arpad; Karoly, Robert; Lamb, Patricia W; Molteni, Carla; Yakel, Jerrel L

2010-11-15

The rat α7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the β9 strand. The replacement of this proline residue at position 180 (P180) by either threonine (α7-P180T) or serine (α7-P180S) slowed the onset of desensitization dramatically, with half-times of ~930 and 700 ms, respectively, compared to 90 ms for the wild-type receptor. To investigate the importance of the hydroxyl group on the position 180 side-chains, the mutant receptors α7-P180Y and α7-P180F were studied and showed half-times of desensitization of 650 and 160 ms, respectively. While a position 180 side-chain OH group may contribute to the slow desensitization rates, α7-P180S and α7-P180V resulted in receptors with similar desensitization rates, suggesting that increased backbone to backbone H bonding expected in the absence of proline at position 180 would likely exert a great effect on desensitization. Single channel recordings indicated that for the α7-P180T receptor there was a significantly reduced closed time without any change in single channel conductance (as compared to wild-type). Kinetic simulations indicated that all changes observed for the mutant channel behaviour were reproduced by decreasing the rate of desensitization, and increasing the microscopic affinity to resting receptors. Molecular dynamics (MD) simulations on a homology model were used to provide insight into likely H bond interactions within the outer β-sheet that occur when the P180 residue is mutated. All mutations analysed increased about twofold the predicted number of H bonds between the residue at position 180 and the backbone of the β10 strand. Moreover, the α7-P180T and α7-P180S mutations also formed some intrastrand H bonds along the β9 strand, although H bonding of the OH groups of the threonine or serine side-chains was predicted to be infrequent. Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand.

Healthcare utilization in older patients using personal emergency response systems: an analysis of electronic health records and medical alert data : Brief Description: A Longitudinal Retrospective Analyses of healthcare utilization rates in older patients using Personal Emergency Response Systems from 2011 to 2015.

PubMed

Agboola, Stephen; Golas, Sara; Fischer, Nils; Nikolova-Simons, Mariana; Op den Buijs, Jorn; Schertzer, Linda; Kvedar, Joseph; Jethwani, Kamal

2017-04-18

Personal Emergency Response Systems (PERS) are traditionally used as fall alert systems for older adults, a population that contributes an overwhelming proportion of healthcare costs in the United States. Previous studies focused mainly on qualitative evaluations of PERS without a longitudinal quantitative evaluation of healthcare utilization in users. To address this gap and better understand the needs of older patients on PERS, we analyzed longitudinal healthcare utilization trends in patients using PERS through the home care management service of a large healthcare organization. Retrospective, longitudinal analyses of healthcare and PERS utilization records of older patients over a 5-years period from 2011-2015. The primary outcome was to characterize the healthcare utilization of PERS patients. This outcome was assessed by 30-, 90-, and 180-day readmission rates, frequency of principal admitting diagnoses, and prevalence of conditions leading to potentially avoidable admissions based on Centers for Medicare and Medicaid Services classification criteria. The overall 30-day readmission rate was 14.2%, 90-days readmission rate was 34.4%, and 180-days readmission rate was 42.2%. While 30-day readmission rates did not increase significantly (p = 0.16) over the study period, 90-days (p = 0.03) and 180-days (p = 0.04) readmission rates did increase significantly. The top 5 most frequent principal diagnoses for inpatient admissions included congestive heart failure (5.7%), chronic obstructive pulmonary disease (4.6%), dysrhythmias (4.3%), septicemia (4.1%), and pneumonia (4.1%). Additionally, 21% of all admissions were due to conditions leading to potentially avoidable admissions in either institutional or non-institutional settings (16% in institutional settings only). Chronic medical conditions account for the majority of healthcare utilization in older patients using PERS. Results suggest that PERS data combined with electronic medical records data can provide useful insights that can be used to improve health outcomes in older patients.

40 CFR 180.499 - Propamocarb hydrochloride, tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for residues. 180.499 Section 180.499 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.499 Propamocarb hydrochloride, tolerances for residues. (a) General. Tolerances are...

40 CFR 180.499 - Propamocarb hydrochloride, tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... for residues. 180.499 Section 180.499 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.499 Propamocarb hydrochloride, tolerances for residues. (a) General. Tolerances are...

40 CFR 180.371 - Thiophanate-methyl; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... residues. 180.371 Section 180.371 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.371 Thiophanate-methyl; tolerances for residues. (a) General. Tolerances are established for...

5 CFR 180.103 - Time limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Time limitations. 180.103 Section 180.103... CLAIMS § 180.103 Time limitations. A claim must be presented in writing within 2 years after it accrues... occurred at a prior time. ...

5 CFR 180.103 - Time limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Time limitations. 180.103 Section 180.103... CLAIMS § 180.103 Time limitations. A claim must be presented in writing within 2 years after it accrues... occurred at a prior time. ...

5 CFR 180.103 - Time limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Time limitations. 180.103 Section 180.103... CLAIMS § 180.103 Time limitations. A claim must be presented in writing within 2 years after it accrues... occurred at a prior time. ...

10 CFR 501.180 - Investigations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Investigations. 501.180 Section 501.180 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Investigations, Violations, Sanctions and Judicial Actions § 501.180 Investigations. (a) General. Pursuant to section 711 of...

14. Toll Plaza and approach signage on 180 looking north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Toll Plaza and approach signage on 1-80 looking north (East 1-80). Photo taken from 250 feet north of 1959 bridge (east-bound 1-80). - Carquinez Bridge, Spanning Carquinez Strait at Interstate 80, Vallejo, Solano County, CA

50 CFR 660.74 - Latitude/longitude coordinates defining the 180 fm (329 m) through 250 fm (457 m) depth contours.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the 180 fm (329 m) through 250 fm (457 m) depth contours. 660.74 Section 660.74 Wildlife and Fisheries.../longitude coordinates defining the 180 fm (329 m) through 250 fm (457 m) depth contours. Boundaries for RCAs... provides coordinates for the 180 fm (329 m) through 250 fm (457 m) depth contours. (a) The 180-fm (329-m...

2 CFR 180.965 - Legal proceedings.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Legal proceedings. 180.965 Section 180.965... ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 180.965 Legal proceedings. Legal proceedings means any criminal proceeding or any civil judicial proceeding, including a proceeding...

24 CFR 891.180 - Physical condition standards; physical inspection requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Physical condition standards; physical inspection requirements. 891.180 Section 891.180 Housing and Urban Development REGULATIONS... DISABILITIES General Program Requirements § 891.180 Physical condition standards; physical inspection...

24 CFR 891.180 - Physical condition standards; physical inspection requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Physical condition standards; physical inspection requirements. 891.180 Section 891.180 Housing and Urban Development REGULATIONS... DISABILITIES General Program Requirements § 891.180 Physical condition standards; physical inspection...

24 CFR 891.180 - Physical condition standards; physical inspection requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Physical condition standards; physical inspection requirements. 891.180 Section 891.180 Housing and Urban Development Regulations... DISABILITIES General Program Requirements § 891.180 Physical condition standards; physical inspection...

24 CFR 891.180 - Physical condition standards; physical inspection requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Physical condition standards; physical inspection requirements. 891.180 Section 891.180 Housing and Urban Development REGULATIONS... DISABILITIES General Program Requirements § 891.180 Physical condition standards; physical inspection...

24 CFR 891.180 - Physical condition standards; physical inspection requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Physical condition standards; physical inspection requirements. 891.180 Section 891.180 Housing and Urban Development REGULATIONS... DISABILITIES General Program Requirements § 891.180 Physical condition standards; physical inspection...

2 CFR 180.995 - Principal.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Principal. 180.995 Section 180.995 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS... § 180.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator...

40 CFR 180.526 - Synthetic isoparaffinic petroleum hydrocarbons; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... hydrocarbons; tolerances for residues. 180.526 Section 180.526 Protection of Environment ENVIRONMENTAL... FOOD Specific Tolerances § 180.526 Synthetic isoparaffinic petroleum hydrocarbons; tolerances for residues. (a) General. Synthetic isoparaffinic petroleum hydrocarbons complying with 21 CFR 172.882 (a) and...

40 CFR 180.526 - Synthetic isoparaffinic petroleum hydrocarbons; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... hydrocarbons; tolerances for residues. 180.526 Section 180.526 Protection of Environment ENVIRONMENTAL... FOOD Specific Tolerances § 180.526 Synthetic isoparaffinic petroleum hydrocarbons; tolerances for residues. (a) General. Synthetic isoparaffinic petroleum hydrocarbons complying with 21 CFR 172.882 (a) and...

40 CFR 68.180 - Emergency response program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Emergency response program. 68.180 Section 68.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.180 Emergency response program...

Cytotoxicity Test and Mass Spectrometry of IPMC

NASA Astrophysics Data System (ADS)

Takashima, Kazuto; Kamamichi, Norihiro; Yagi, Tohru; Asaka, Kinji; Mukai, Toshiharu

Ionic polymer-metal composite (IPMC) is a promising material in biomedical actuators and sensors because IPMC is soft and flexible, leading to the safety of the device itself. The purpose of this study is to investigate the biocompatibility of IPMC by in vitro experiments, in order to evaluate the applicability in biomedical fields. In addition to an IPMC specimen prepared by the conventional “impregnation-reduction method” using cationic gold complexes and reducing agents, two specimens were prepared by processes in addition to that used for the conventional IPMC specimen. One specimen was reduced in Na2SO3 solution and another specimen was cleaned in H2O2 solution. Colony-forming test using Chinese hamster V79 cells shows high cytotoxicity of all IPMC specimens. Examination of direct inlet mass spectrometry (DI-MS) revealed that the peak intensity of gold complex (particularly, m/z=180) was different from that of Nafion film. Monitoring the peak at m/z=180 showed a remnant with the structure of phenanthroline in IPMC specimens which were not cleaned in H2O2 solution.

Vacancies and holes in bulk and at 180° domain walls in lead titanate

NASA Astrophysics Data System (ADS)

Paillard, Charles; Geneste, Grégory; Bellaiche, Laurent; Dkhil, Brahim

2017-12-01

Domain walls (DWs) in ferroic materials exhibit a plethora of unexpected properties that are different from the adjacent ferroic domains. Still, the intrinsic/extrinsic origin of these properties remains an open question. Here, density functional theory calculations are used to investigate the interaction between vacancies and 180° DWs in the prototypical ferroelectric PbTiO3, with a special emphasis on cationic vacancies and released holes. All vacancies are more easily formed within the DW than in the domains. This is interpreted, using a phenomenological model, as the partial compensation of an extra-tensile stress when the defect is created inside the DW. Oxygen vacancies are found to be always fully ionized, independently of the thermodynamic conditions, while cationic vacancies can be either neutral or partially ionized (oxygen-rich conditions), or fully ionized (oxygen-poor conditions). Therefore, in oxidizing conditions, holes are induced by neutral and partially ionized Pb vacancies. In the bulk PbTiO3, these holes are more stable as delocalized rather than small polarons, but at DWs, the two forms are found to be possible.

Optimization of loading ratio of ErN as regenerator of 4K-GM cryocooler

NASA Astrophysics Data System (ADS)

Nakagawa, T.; Miyauchi, T.; Shiraishi, T.; Seino, S.; Yamamoto, T. A.; Fujimoto, Y.; Masuyama, S.

2017-09-01

High purity erbium nitride (ErN) spheres with the size range of 150-180 µm and 180-212 µm were prepared by nitriding Er metal spheres with low oxygen content. The initial regenerator material of HoCu2 on the cold end of the second regenerator column in 4K-GM cryocooler with nominal cooling power of 0.1 W at 4.2 K was replaced by ErN with different sizes. Higher cooling power was obtained when ErN of smaller size with lower oxygen content was used. We investigated the effect of partial replacement of HoCu2 by ErN in the cold end side of second stage regenerator column on cooling power of 4K-GM cryocoolers. When ErN were substituted for 20 % of HoCu2, the cooling power at 4.2 K reached 0.318 W. This value was 1.36 times as high as that of the cooling power of the GM cryocooler with commercially available regenerator arrangement. Therefore, use of ErN regenerator materials leads to the energy-saving and downsizing of 4K-GM cryocoolers.

2 CFR 180.965 - Legal proceedings.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Legal proceedings. 180.965 Section 180.965... ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 180.965 Legal proceedings. Legal proceedings means any criminal proceeding or any civil judicial proceeding, including a proceeding...

2 CFR 180.975 - Notice.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Notice. 180.975 Section 180.975 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 180.975...

40 CFR 436.180 - Applicability; description of the phosphate rock subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... phosphate rock subcategory. 436.180 Section 436.180 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORY Phosphate Rock Subcategory § 436.180 Applicability; description of the phosphate rock... bearing rock, ore or earth for the phosphate content. [43 FR 9809, Mar. 10, 1978] ...

40 CFR 436.180 - Applicability; description of the phosphate rock subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... phosphate rock subcategory. 436.180 Section 436.180 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORY Phosphate Rock Subcategory § 436.180 Applicability; description of the phosphate rock... bearing rock, ore or earth for the phosphate content. [43 FR 9809, Mar. 10, 1978] ...

40 CFR 436.180 - Applicability; description of the phosphate rock subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... phosphate rock subcategory. 436.180 Section 436.180 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORY Phosphate Rock Subcategory § 436.180 Applicability; description of the phosphate rock... bearing rock, ore or earth for the phosphate content. [43 FR 9809, Mar. 10, 1978] ...

49 CFR 180.505 - Quality assurance program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Quality assurance program. 180.505 Section 180.505... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.505 Quality assurance program. The quality assurance program requirements of § 179.7 of this subchapter apply. ...

40 CFR 180.300 - Ethephon; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Ethephon; tolerances for residues. 180.300 Section 180.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.300...

2 CFR 180.915 - Civil judgment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Civil judgment. 180.915 Section 180.915... ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 180.915 Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction, whether...

ABCG2-overexpressing S1-M1-80 cell xenografts in nude mice keep original biochemistry and cell biological properties.

PubMed

Wang, Fang; Liang, Yong-Ju; Wu, Xing-Ping; Su, Xiao-Dong; Fu, Li-Wu

2012-03-01

S1-M1-80 cells, derived from human colon carcinoma S1 cells, are mitoxantrone-selected ABCG2-overexpressing cells and are widely used in in vitro studies of multidrug resistance(MDR). In this study, S1-M1-80 cell xenografts were established to investigate whether the MDR phenotype and cell biological properties were maintained in vivo. Our results showed that the proliferation, cell cycle, and ABCG2 expression level in S1-M1-80 cells were similar to those in cells isolated from S1-M1-80 cell xenografts (named xS1-M1-80 cells). Consistently, xS1-M1-80 cells exhibited high levels of resistance to ABCG2 substrates such as mitoxantrone and topotecan, but remained sensitive to the non-ABCG2 substrate cisplatin. Furthermore, the specific ABCG2 inhibitor Ko143 potently sensitized xS1-M1-80 cells to mitoxantrone and topotecan. These results suggest that S1-M1-80 cell xenografts in nude mice retain their original cytological characteristics at 9 weeks. Thus, this model could serve as a good system for further investigation of ABCG2-mediated MDR.

21 CFR 211.180 - General requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 4 2014-04-01 2014-04-01 false General requirements. 211.180 Section 211.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Records and Reports § 211.180...

21 CFR 211.180 - General requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 4 2012-04-01 2012-04-01 false General requirements. 211.180 Section 211.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Records and Reports § 211.180...

21 CFR 211.180 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 4 2011-04-01 2011-04-01 false General requirements. 211.180 Section 211.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Records and Reports § 211.180...

21 CFR 211.180 - General requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 4 2013-04-01 2013-04-01 false General requirements. 211.180 Section 211.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Records and Reports § 211.180...

2 CFR 180.965 - Legal proceedings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Legal proceedings. 180.965 Section 180.965 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS... § 180.965 Legal proceedings. Legal proceedings means any criminal proceeding or any civil judicial...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

24 CFR 180.500 - Discovery.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

24 CFR 180.500 - Discovery.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

24 CFR 180.500 - Discovery.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

24 CFR 180.500 - Discovery.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

24 CFR 180.500 - Discovery.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...

38 CFR 17.180 - Delegation of authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Delegation of authority. 17.180 Section 17.180 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Veterans Canteen Service § 17.180 Delegation of authority. In connection with the Veterans Canteen Service...

38 CFR 17.180 - Delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Delegation of authority. 17.180 Section 17.180 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Veterans Canteen Service § 17.180 Delegation of authority. In connection with the Veterans Canteen Service...

20 CFR 655.180 - Audit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Audit. 655.180 Section 655.180 Employees... United States (H-2A Workers) Integrity Measures § 655.180 Audit. The CO may conduct audits of applications for which certifications have been granted. (a) Discretion. The applications selected for audit...

46 CFR 154.180 - Contiguous hull structure: Welding procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Contiguous hull structure: Welding procedure. 154.180 Section 154.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... Equipment Hull Structure § 154.180 Contiguous hull structure: Welding procedure. Welding procedure tests for...

46 CFR 154.180 - Contiguous hull structure: Welding procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Contiguous hull structure: Welding procedure. 154.180 Section 154.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... Equipment Hull Structure § 154.180 Contiguous hull structure: Welding procedure. Welding procedure tests for...

46 CFR 154.180 - Contiguous hull structure: Welding procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Contiguous hull structure: Welding procedure. 154.180 Section 154.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... Equipment Hull Structure § 154.180 Contiguous hull structure: Welding procedure. Welding procedure tests for...

46 CFR 154.180 - Contiguous hull structure: Welding procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Contiguous hull structure: Welding procedure. 154.180 Section 154.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... Equipment Hull Structure § 154.180 Contiguous hull structure: Welding procedure. Welding procedure tests for...

2 CFR 180.915 - Civil judgment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Civil judgment. 180.915 Section 180.915... ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 180.915 Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction, whether...

7 CFR 800.180 - Summary cancellation of licenses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Summary cancellation of licenses. 800.180 Section 800.180 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND... Licenses and Authorizations (for Individuals Only) § 800.180 Summary cancellation of licenses. A license...

[The adaptation reactions in hormonal systems to the internal use of mineral waters].

PubMed

Polushina, N D

1991-01-01

A single intake of mineral water Essentuki 17 by male Wistar rats (n-130, b. w. 180-250 g) leads to stress reactions. It is evident from elevated levels of ACTH, hydrocortisone, leuenkephaline, glucagon and gastrin. Course intake of the water brings about a rise in most of the hormones levels studied. However, single doses of Essentuki 17 inhibit production of hormones in the adrenals, hypophysis, hypothalamus, the system of endogenic opiates. The enhancement of relevant levels are noted in the gastroenteropancreatic system.

Process of activation of a palladium catalyst system

DOEpatents

Sobolevskiy, Anatoly [Orlando, FL; Rossin, Joseph A [Columbus, OH; Knapke, Michael J [Columbus, OH

2011-08-02

Improved processes for activating a catalyst system used for the reduction of nitrogen oxides are provided. In one embodiment, the catalyst system is activated by passing an activation gas stream having an amount of each of oxygen, water vapor, nitrogen oxides, and hydrogen over the catalyst system and increasing a temperature of the catalyst system to a temperature of at least 180.degree. C. at a heating rate of from 1-20.degree./min. Use of activation processes described herein leads to a catalyst system with superior NOx reduction capabilities.

Effects of lead-contaminated sediment on Rana sphenocephala tadpoles.

PubMed

Sparling, Donald W; Krest, Sherry; Ortiz-Santaliestra, Manuel

2006-10-01

We exposed larval southern leopard frogs (Rana sphenocephala) to lead-contaminated sediments to determine the lethal and sublethal effects of this metal. Tadpoles were laboratory-raised from early free-swimming stage through metamorphosis at lead concentrations of 45, 75, 180, 540, 2360, 3940, 5520, and 7580 mg/kg dry weight in sediment. Corresponding pore water lead concentrations were 123, 227, 589, 1833, 8121, 13,579, 19,038, and 24,427 microg/L. Tadpoles exposed to lead concentrations in sediment of 3940 mg/kg or higher died within 2 to 5 days of exposure. At lower concentrations, mortality through metamorphosis ranged from 3.5% at 45 mg/kg lead to 37% at 2360 mg/kg lead in sediment. The LC50 value for lead in sediment was 3728 mg/kg (95% CI = 1315 to 72,847 mg/kg), which corresponded to 12,539 microg/L lead in pore water (95% CI = 4000 to 35,200 microg/L). Early growth and development were depressed at 2,360 mg/kg lead in sediment (8100 microg/L in pore water) but differences were not evident by the time of metamorphosis. The most obvious effect of lead was its pronounced influence on skeletal development. Whereas tadpoles at 45 mg/kg lead in sediment did not display permanent abnormalities, skeletal malformations increased in frequency and severity at all higher lead concentrations. By 2360 mg/kg, 100% of surviving metamorphs displayed severe spinal problems, reduced femur and humerus lengths, deformed digits, and other bone malformations. Lead concentrations in tissues correlated positively with sediment and pore water concentrations.

Effects of lead-contaminated sediment on Rana sphenocephala tadpoles

USGS Publications Warehouse

Sparling, D.W.; Krest, S.K.; Ortiz-Santaliestra, M.

2006-01-01

We exposed larval southern leopard frogs (Rana sphenocephala) to lead-contaminated sediments to determine the lethal and sublethal effects of this metal. Tadpoles were laboratory-raised from early free-swimming stage through metamorphosis at lead concentrations of 45, 75, 180, 540, 2360, 3940, 5520, and 7580 mg/kg dry weight in sediment. Corresponding pore water lead concentrations were 123, 227, 589, 1833, 8121, 13,579, 19,038, and 24,427 ug/L. Tadpoles exposed to lead concentrations in sediment of 3940 mg/kg or higher died within 2 to 5 days of exposure. At lower concentrations, mortality through metamorphosis ranged from 3.5% at 45 mg/kg lead to 37% at 2360 mg/kg lead in sediment. The LC50 value for lead in sediment was 3728 mg/kg (95% CI=1315 to 72,847 mg/kg), which corresponded to 12,539 ug/L lead in pore water (95% CI= 4000 to 35,200 ug/L). Early growth and development were depressed at 2,360 mg/kg lead in sediment (8100 ug/L in pore water) but differences were not evident by the time of metamorphosis. The most obvious effect of lead was its pronounced influence on skeletal development. Whereas tadpoles at 45 mg/kg lead in sediment did not display permanent abnormalities, skeletal malformations increased in frequency and severity at all higher lead concentrations. By 2360 mg/kg, 100% of surviving metamorphs displayed severe spinal problems, reduced femur and humerus lengths, deformed digits, and other bone malformations. Lead concentrations in tissues correlated positively with sediment and pore water concentrations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buchko, Garry W.; Lin, Genyao; Tarasevich, Barbara J.

Amelogenesis imperfecta describes a group of inherited disorders that results in defective tooth enamel. Two disorders associated with human amelogenesis imperfecta are the point mutations T21?I or P40?T in amelogenin, the dominant protein present during the early stages of enamel biomineralization. The biophysical properties of wildtype murine amelogenin (M180) and two proteins containing the equivalent mutations in murine amelogenin, T21?I (M180-I) and P41?T (M180-T), were probed by NMR spectroscopy. At low protein concentration (0.1 mM), M180, M180-I, and M180-T are predomi- nately monomeric at pH 3.0 in 2% acetic acid and neither mutation produces a major structural change. Chemical shiftmore » perturbation studies as a function of protein (0.1–1.8 mM) or NaCl (0–400 mM) concentra- tions show that the mutations affect the self-association properties by causing self-assembly at lower protein or salt concentrations, relative to wildtype amelogenin, with the largest effect observed for M180-I. Under both conditions, the premature self-assembly is initiated near the N-terminus, providing further evidence for the importance of this region in the self-assembly process. The self-association of M180-I and M180-T at lower protein concentrations and lower ionic strengths than wildtype M180 may account for the clinical phenotypes of these mutations, defective enamel formation.« less

Molecular characterization and in situ mRNA localization of the neural recognition molecule J1-160/180: a modular structure similar to tenascin

PubMed Central

1993-01-01

The oligodendrocyte-derived extracellular matrix glycoprotein J1- 160/180 is a recognition molecule expressed exclusively in the central nervous system. J1-160/180 has been shown to be adhesive for astrocytes and repellent towards neurons and growth cones. We report here the complete nucleotide sequence of J1-160/180 in the rat. The predicted amino acid sequence showed a structural architecture very similar to tenascin: a cysteine-rich amino terminal region is followed by 4.5 epidermal growth factor-like repeats, 9 fibronectin type III homologous repeats and a domain homologous to fibrinogen. Sequence comparison analysis revealed highest homology of rat J1-160/180 to mouse tenascin and chicken restrictin with a similarity of 66% and 85%, respectively. The J1-160/180-coding mRNA is derived from a single copy gene. Using the polymerase chain reaction we could show that two J1-160/180 isoforms are generated by alternative splicing of the sixth fibronectin type III homologous repeat. Localization of J1-160/180 mRNA by in situ hybridization in the cerebellum, hippocampus and olfactory bulb confirmed the expression of J1-160/180 by oligodendrocytes with a peak of transcription at 7-14 d after birth, indicating a functional role during myelination. In addition, J1-160/180-specific RNA was found in a small subset of neurons in all three structures of the CNS analyzed. These neurons continue to express J1-160/180 in the adult. PMID:7679676

40 CFR 180.30 - Judicial review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Judicial review. 180.30 Section 180.30... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.30 Judicial review. (a) Under FFDCA section 408(h), judicial review is available in the United States Courts of Appeal as to the...

40 CFR 417.180 - Applicability; description of the manufacture of drum dried detergents subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... manufacture of drum dried detergents subcategory. 417.180 Section 417.180 Protection of Environment... POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.180 Applicability; description of the manufacture of drum dried detergents subcategory. The provisions of this subpart are...

40 CFR 180.501 - Hydroprene; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Hydroprene; tolerances for residues. 180.501 Section 180.501 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.501 Hydroprene; tolerances for residues. (a)...

30 CFR 62.180 - Training.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Training. 62.180 Section 62.180 Mineral... OCCUPATIONAL NOISE EXPOSURE § 62.180 Training. (a) The mine operator must, within 30 days of a miner's enrollment into a hearing conservation program, provide the miner with training. The mine operator must give...

40 CFR 180.1050 - Nitrogen; exemption from the requirements of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Nitrogen; exemption from the requirements of a tolerance. 180.1050 Section 180.1050 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1050 Nitrogen; exemption from the requirements of a tolerance. The...

2 CFR 180.5 - What does this part do?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What does this part do? 180.5 Section 180.5 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) § 180.5...

40 CFR 436.180 - Applicability; description of the phosphate rock subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... phosphate rock subcategory. 436.180 Section 436.180 Protection of Environment ENVIRONMENTAL PROTECTION... Phosphate Rock Subcategory § 436.180 Applicability; description of the phosphate rock subcategory. The provisions of this subpart are applicable to the mining and the processing of phosphate bearing rock, ore or...

40 CFR 436.180 - Applicability; description of the phosphate rock subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... phosphate rock subcategory. 436.180 Section 436.180 Protection of Environment ENVIRONMENTAL PROTECTION... Phosphate Rock Subcategory § 436.180 Applicability; description of the phosphate rock subcategory. The provisions of this subpart are applicable to the mining and the processing of phosphate bearing rock, ore or...

46 CFR 180.204 - Survival craft-vessels operating on coastwise routes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft-vessels operating on coastwise routes. 180.204 Section 180.204 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL... Craft § 180.204 Survival craft—vessels operating on coastwise routes. (a) Except as allowed by paragraph...

40 CFR 180.7 - Petitions proposing tolerances or exemptions for pesticide residues in or on raw agricultural...

Code of Federal Regulations, 2013 CFR

2013-07-01

... exemptions for pesticide residues in or on raw agricultural commodities or processed foods. 180.7 Section 180.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.7 Petitions...

40 CFR 180.7 - Petitions proposing tolerances or exemptions for pesticide residues in or on raw agricultural...

Code of Federal Regulations, 2012 CFR

2012-07-01

... exemptions for pesticide residues in or on raw agricultural commodities or processed foods. 180.7 Section 180.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.7 Petitions...

40 CFR 180.7 - Petitions proposing tolerances or exemptions for pesticide residues in or on raw agricultural...

Code of Federal Regulations, 2014 CFR

2014-07-01

... exemptions for pesticide residues in or on raw agricultural commodities or processed foods. 180.7 Section 180.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.7 Petitions...

49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

Code of Federal Regulations, 2010 CFR

2010-10-01

... specification tank cars. 180.509 Section 180.509 Transportation Other Regulations Relating to Transportation... REGULATIONS CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.509 Requirements for inspection and test of specification tank cars. (a) General. (1) Each tank...

49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

Code of Federal Regulations, 2011 CFR

2011-10-01

... specification tank cars. 180.509 Section 180.509 Transportation Other Regulations Relating to Transportation...) CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.509 Requirements for inspection and test of specification tank cars. (a) General. (1) Each tank car facility shall...

40 CFR 180.467 - Carbon disulfide; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Carbon disulfide; tolerances for residues. 180.467 Section 180.467 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.467 Carbon disulfide; tolerances for...

40 CFR 180.467 - Carbon disulfide; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Carbon disulfide; tolerances for residues. 180.467 Section 180.467 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.467 Carbon disulfide; tolerances for...

40 CFR 180.467 - Carbon disulfide; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Carbon disulfide; tolerances for residues. 180.467 Section 180.467 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.467 Carbon disulfide; tolerances for...

21 CFR 357.180 - Professional labeling.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Products § 357.180 Professional labeling. The labeling provided to health professionals (but not to the... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Professional labeling. 357.180 Section 357.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS...

40 CFR 180.284 - Zinc phosphide; tolerances for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Zinc phosphide; tolerances for residues. 180.284 Section 180.284 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.284 Zinc phosphide; tolerances for...

40 CFR 180.284 - Zinc phosphide; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Zinc phosphide; tolerances for residues. 180.284 Section 180.284 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.284 Zinc phosphide; tolerances for...

40 CFR 180.284 - Zinc phosphide; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Zinc phosphide; tolerances for residues. 180.284 Section 180.284 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.284 Zinc phosphide; tolerances for...

10 CFR 72.180 - Physical protection plan.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Physical protection plan. 72.180 Section 72.180 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Physical Protection § 72.180 Physical protection plan. The licensee shall establish, maintain, and follow a detailed...

10 CFR 72.180 - Physical protection plan.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Physical protection plan. 72.180 Section 72.180 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Physical Protection § 72.180 Physical protection plan. The licensee shall establish, maintain, and follow a detailed...

10 CFR 72.180 - Physical protection plan.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Physical protection plan. 72.180 Section 72.180 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Physical Protection § 72.180 Physical protection plan. The licensee shall establish, maintain, and follow a detailed...

10 CFR 72.180 - Physical protection plan.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Physical protection plan. 72.180 Section 72.180 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Physical Protection § 72.180 Physical protection plan. The licensee shall establish, maintain, and follow a detailed...

10 CFR 72.180 - Physical protection plan.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Physical protection plan. 72.180 Section 72.180 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Physical Protection § 72.180 Physical protection plan. The licensee shall establish, maintain, and follow a detailed...

40 CFR 180.5 - Zero tolerances.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Zero tolerances. 180.5 Section 180.5... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Definitions and Interpretative Regulations § 180.5 Zero tolerances. A zero tolerance means that no amount of the pesticide chemical may remain on the raw...

40 CFR 180.5 - Zero tolerances.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Zero tolerances. 180.5 Section 180.5... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Definitions and Interpretative Regulations § 180.5 Zero tolerances. A zero tolerance means that no amount of the pesticide chemical may remain on the raw...

40 CFR 180.5 - Zero tolerances.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Zero tolerances. 180.5 Section 180.5... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Definitions and Interpretative Regulations § 180.5 Zero tolerances. A zero tolerance means that no amount of the pesticide chemical may remain on the raw...

21 CFR 172.180 - Stannous chloride.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Stannous chloride. 172.180 Section 172.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Preservatives § 172.180 Stannous chloride. The food additive stannous chloride may be safely used for color...

7 CFR 956.180 - Reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports. 956.180 Section 956.180 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.180 Reports. (a) Each... to September 1, such report shall be furnished to the Committee by September 30, and that for Walla...

7 CFR 956.180 - Reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Reports. 956.180 Section 956.180 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.180 Reports. (a) Each... to September 1, such report shall be furnished to the Committee by September 30, and that for Walla...

40 CFR 180.30 - Judicial review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.30 Judicial review. (a) Under FFDCA section 408(h), judicial review is available in the United States Courts of Appeal as to the... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Judicial review. 180.30 Section 180.30...

40 CFR 180.30 - Judicial review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.30 Judicial review. (a) Under FFDCA section 408(h), judicial review is available in the United States Courts of Appeal as to the... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Judicial review. 180.30 Section 180.30...

40 CFR 180.30 - Judicial review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.30 Judicial review. (a) Under FFDCA section 408(h), judicial review is available in the United States Courts of Appeal as to the... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Judicial review. 180.30 Section 180.30...

40 CFR 180.1016 - Ethylene; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Ethylene; exemption from the requirement of a tolerance. 180.1016 Section 180.1016 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1016 Ethylene; exemption from the requirement of a tolerance. Ethylene is...

27 CFR 555.180 - Prohibitions relating to unmarked plastic explosives.

Code of Federal Regulations, 2010 CFR

2010-04-01

... unmarked plastic explosives. 555.180 Section 555.180 Alcohol, Tobacco Products, and Firearms BUREAU OF... Marking of Plastic Explosives § 555.180 Prohibitions relating to unmarked plastic explosives. (a) No person shall manufacture any plastic explosive that does not contain a detection agent. (b) No person...

21 CFR 180.25 - Mannitol.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Mannitol. 180.25 Section 180.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES... for Certain Food Additives § 180.25 Mannitol. (a) Mannitol is the chemical 1,2,3,4,5,6,-hexanehexol...

21 CFR 180.30 - Brominated vegetable oil.

Code of Federal Regulations, 2014 CFR

2014-04-01

... ADDITIVES PERMITTED IN FOOD OR IN CONTACT WITH FOOD ON AN INTERIM BASIS PENDING ADDITIONAL STUDY Specific Requirements for Certain Food Additives § 180.30 Brominated vegetable oil. The food additive brominated... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Brominated vegetable oil. 180.30 Section 180.30...

21 CFR 180.25 - Mannitol.

Code of Federal Regulations, 2013 CFR

2013-04-01

... CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED IN FOOD OR IN CONTACT WITH FOOD ON AN INTERIM BASIS PENDING ADDITIONAL STUDY Specific Requirements for Certain Food Additives § 180.25 Mannitol. (a) Mannitol is the... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Mannitol. 180.25 Section 180.25 Food and Drugs...

40 CFR 408.180 - Applicability; description of the West Coast hand-butchered salmon processing subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Coast hand-butchered salmon processing subcategory. 408.180 Section 408.180 Protection of Environment... PROCESSING POINT SOURCE CATEGORY West Coast Hand-Butchered Salmon Processing Subcategory § 408.180 Applicability; description of the West Coast hand-butchered salmon processing subcategory. The provisions of...

40 CFR 408.180 - Applicability; description of the West Coast hand-butchered salmon processing subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Coast hand-butchered salmon processing subcategory. 408.180 Section 408.180 Protection of Environment... PROCESSING POINT SOURCE CATEGORY West Coast Hand-Butchered Salmon Processing Subcategory § 408.180 Applicability; description of the West Coast hand-butchered salmon processing subcategory. The provisions of...

2 CFR 180.365 - What must I do if I learn of information required under § 180.355 after entering into a covered...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What must I do if I learn of information... Participants § 180.365 What must I do if I learn of information required under § 180.355 after entering into a... learn either that— (a) You failed to disclose information earlier, as required by § 180.355; or (b) Due...

2 CFR 180.350 - What must I do if I learn of information required under § 180.335 after entering into a covered...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What must I do if I learn of information... Participants § 180.350 What must I do if I learn of information required under § 180.335 after entering into a... transaction if you learn either that— (a) You failed to disclose information earlier, as required by § 180.335...

Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

PubMed Central

2015-01-01

Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases. A highly selective EP2 antagonist could be useful as a drug to mitigate the inflammatory consequences of EP2 activation. We recently identified a cinnamic amide class of EP2 antagonists. The lead compound in this class (5d) displays anti-inflammatory and neuroprotective actions. However, this compound exhibited moderate selectivity to EP2 over the DP1 prostanoid receptor (∼10-fold) and low aqueous solubility. We now report compounds that display up to 180-fold selectivity against DP1 and up to 9-fold higher aqueous solubility than our previous lead. The newly developed compounds also display higher selectivity against EP4 and IP receptors and a comparable plasma pharmacokinetics. Thus, these compounds are useful for proof of concept studies in a variety of models where EP2 activation is playing a deleterious role. PMID:24773616

Giant strain with ultra-low hysteresis and high temperature stability in grain oriented lead-free K0.5Bi0.5TiO3-BaTiO3-Na0.5Bi0.5TiO3 piezoelectric materials

PubMed Central

Maurya, Deepam; Zhou, Yuan; Wang, Yaojin; Yan, Yongke; Li, Jiefang; Viehland, Dwight; Priya, Shashank

2015-01-01

We synthesized grain-oriented lead-free piezoelectric materials in (K0.5Bi0.5TiO3-BaTiO3-xNa0.5Bi0.5TiO3 (KBT-BT-NBT) system with high degree of texturing along the [001]c (c-cubic) crystallographic orientation. We demonstrate giant field induced strain (~0.48%) with an ultra-low hysteresis along with enhanced piezoelectric response (d33 ~ 190pC/N) and high temperature stability (~160°C). Transmission electron microscopy (TEM) and piezoresponse force microscopy (PFM) results demonstrate smaller size highly ordered domain structure in grain-oriented specimen relative to the conventional polycrystalline ceramics. The grain oriented specimens exhibited a high degree of non-180° domain switching, in comparison to the randomly axed ones. These results indicate the effective solution to the lead-free piezoelectric materials. PMID:25716551

Giant strain with ultra-low hysteresis and high temperature stability in grain oriented lead-free K₀̣₅Bi₀̣₅TiO₃-BaTiO₃-Na₀̣₅Bi₀̣₅TiO₃ piezoelectric materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maurya, Deepam; Zhou, Yuan; Wang, Yaojin

2015-02-26

We synthesized grain-oriented lead-free piezoelectric materials in (K₀̣₅Bi₀̣₅TiO₃-BaTiO₃-xNa₀̣₅Bi₀̣₅TiO₃ (KBT-BT-NBT) system with high degree of texturing along the [001]c (c-cubic) crystallographic orientation. We demonstrate giant field induced strain (~0.48%) with an ultra-low hysteresis along with enhanced piezoelectric response (d₃₃ ~ 190pC/N) and high temperature stability (~160°C). Transmission electron microscopy (TEM) and piezoresponse force microscopy (PFM) results demonstrate smaller size highly ordered domain structure in grain-oriented specimen relative to the conventional polycrystalline ceramics. The grain oriented specimens exhibited a high degree of non-180° domain switching, in comparison to the randomly axed ones. These results indicate the effective solution to the lead-free piezoelectricmore » materials.« less

40 CFR 180.296 - Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamide; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-methyl-cis-crotonamide; tolerances for residues. 180.296 Section 180.296 Protection of Environment... RESIDUES IN FOOD Specific Tolerances § 180.296 Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamide; tolerances for residues. (a) General. Tolerances are established for residues of the insecticide Dimethyl...

40 CFR 180.1240 - Thymol; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Thymol; exemption from the requirement of a tolerance. 180.1240 Section 180.1240 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1240 Thymol;...

40 CFR 180.367 - n-Octyl bicycloheptenedi-carboximide; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false n-Octyl bicycloheptenedi-carboximide; tolerances for residues. 180.367 Section 180.367 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.367 n-Octyl...

40 CFR 180.1072 - Poly-D-glucosamine (chitosan); exemption from the requirement of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Poly-D-glucosamine (chitosan); exemption from the requirement of a tolerance. 180.1072 Section 180.1072 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1072 Poly-D-glucosamine (chitosan); exemption from the...

46 CFR 180.78 - Stowage of life jackets.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Stowage of life jackets. 180.78 Section 180.78 Shipping...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.78 Stowage of life jackets. (a) General. Unless otherwise stated in this section, life jackets must be stored in convenient places...

46 CFR 180.75 - Life jacket lights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Life jacket lights. 180.75 Section 180.75 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.75 Life jacket lights. (a) Each life jacket carried on a vessel on oceans, coastwise, or Great Lakes route, must have a life jacket...

46 CFR 180.75 - Life jacket lights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Life jacket lights. 180.75 Section 180.75 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.75 Life jacket lights. (a) Each life jacket carried on a vessel on oceans, coastwise, or Great Lakes route, must have a life jacket...

46 CFR 180.78 - Stowage of life jackets.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Stowage of life jackets. 180.78 Section 180.78 Shipping...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.78 Stowage of life jackets. (a) General. Unless otherwise stated in this section, life jackets must be stored in convenient places...

2 CFR 180.505 - Who uses the EPLS?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Who uses the EPLS? 180.505 Section 180.505 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS... excluded or disqualified, as required under § 180.320; or (2) Persons with whom they are entering into...

40 CFR 180.522 - Fumigants for processed grains used in production of fermented malt beverage; tolerances for...

Code of Federal Regulations, 2010 CFR

2010-07-01

... production of fermented malt beverage; tolerances for residues. 180.522 Section 180.522 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.522 Fumigants for processed grains used in production of fermented malt beverage; tolerances for residues. (a) General. Fumigants for processed grain...

46 CFR 180.130 - Stowage of survival craft.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Stowage of survival craft. 180.130 Section 180.130... TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.130 Stowage of survival craft. (a) Each survival craft must be: (1) Secured to the vessel by a painter with a...

49 CFR 180.507 - Qualification of tank cars.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the transportation...

49 CFR 180.507 - Qualification of tank cars.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the transportation...

49 CFR 180.507 - Qualification of tank cars.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Qualification of tank cars. 180.507 Section 180... QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used...

49 CFR 180.507 - Qualification of tank cars.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the transportation...

49 CFR 180.507 - Qualification of tank cars.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the transportation...

40 CFR 180.1148 - Occlusion Bodies of the Granulosis Virus of Cydia pomenella; tolerance exemption.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Virus of Cydia pomenella; tolerance exemption. 180.1148 Section 180.1148 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1148 Occlusion Bodies of the Granulosis Virus of Cydia... of the microbial pest control agent Occlusion Bodies of the Granulosis Virus of Cydia pomonella...

40 CFR 180.1148 - Occlusion Bodies of the Granulosis Virus of Cydia pomenella; tolerance exemption.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Virus of Cydia pomenella; tolerance exemption. 180.1148 Section 180.1148 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1148 Occlusion Bodies of the Granulosis Virus of Cydia... of the microbial pest control agent Occlusion Bodies of the Granulosis Virus of Cydia pomonella...

40 CFR 180.1148 - Occlusion Bodies of the Granulosis Virus of Cydia pomenella; tolerance exemption.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Virus of Cydia pomenella; tolerance exemption. 180.1148 Section 180.1148 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1148 Occlusion Bodies of the Granulosis Virus of Cydia... of the microbial pest control agent Occlusion Bodies of the Granulosis Virus of Cydia pomonella...

40 CFR 180.1148 - Occlusion Bodies of the Granulosis Virus of Cydia pomenella; tolerance exemption.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Virus of Cydia pomenella; tolerance exemption. 180.1148 Section 180.1148 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1148 Occlusion Bodies of the Granulosis Virus of Cydia... of the microbial pest control agent Occlusion Bodies of the Granulosis Virus of Cydia pomonella...

40 CFR 180.1148 - Occlusion Bodies of the Granulosis Virus of Cydia pomenella; tolerance exemption.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Virus of Cydia pomenella; tolerance exemption. 180.1148 Section 180.1148 Protection of Environment... RESIDUES IN FOOD Exemptions From Tolerances § 180.1148 Occlusion Bodies of the Granulosis Virus of Cydia... of the microbial pest control agent Occlusion Bodies of the Granulosis Virus of Cydia pomonella...

40 CFR 180.1090 - Lactic acid; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Lactic acid; exemption from the requirement of a tolerance. 180.1090 Section 180.1090 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1090 Lactic acid; exemption from the requirement of a tolerance. Lactic acid...

40 CFR 180.1090 - Lactic acid; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Lactic acid; exemption from the requirement of a tolerance. 180.1090 Section 180.1090 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1090 Lactic acid; exemption from the requirement of a tolerance. Lactic acid...

40 CFR 180.1090 - Lactic acid; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Lactic acid; exemption from the requirement of a tolerance. 180.1090 Section 180.1090 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1090 Lactic acid; exemption from the requirement of a tolerance. Lactic acid...

40 CFR 180.1090 - Lactic acid; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Lactic acid; exemption from the requirement of a tolerance. 180.1090 Section 180.1090 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1090 Lactic acid; exemption from the requirement of a tolerance. Lactic acid...

40 CFR 180.1090 - Lactic acid; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Lactic acid; exemption from the requirement of a tolerance. 180.1090 Section 180.1090 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1090 Lactic acid; exemption from the requirement of a tolerance. Lactic acid...

40 CFR 421.180 - Applicability: Description of the primary and secondary germanium and gallium subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... primary and secondary germanium and gallium subcategory. 421.180 Section 421.180 Protection of Environment... POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.180 Applicability: Description of the primary and secondary germanium and gallium subcategory. The provisions of this subpart are...

40 CFR 421.180 - Applicability: Description of the primary and secondary germanium and gallium subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... primary and secondary germanium and gallium subcategory. 421.180 Section 421.180 Protection of Environment... POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.180 Applicability: Description of the primary and secondary germanium and gallium subcategory. The provisions of this subpart are...

40 CFR 421.180 - Applicability: Description of the primary and secondary germanium and gallium subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... primary and secondary germanium and gallium subcategory. 421.180 Section 421.180 Protection of Environment... POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.180 Applicability: Description of the primary and secondary germanium and gallium subcategory. The provisions of this subpart are...

40 CFR 421.180 - Applicability: Description of the primary and secondary germanium and gallium subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... primary and secondary germanium and gallium subcategory. 421.180 Section 421.180 Protection of Environment... POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.180 Applicability: Description of the primary and secondary germanium and gallium subcategory. The provisions of this subpart are...

40 CFR 421.180 - Applicability: Description of the primary and secondary germanium and gallium subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... primary and secondary germanium and gallium subcategory. 421.180 Section 421.180 Protection of Environment... POINT SOURCE CATEGORY Primary and Secondary Germanium and Gallium Subcategory § 421.180 Applicability: Description of the primary and secondary germanium and gallium subcategory. The provisions of this subpart are...

2 CFR 180.880 - What factors may influence the debarring official during reconsideration?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What factors may influence the debarring official during reconsideration? 180.880 Section 180.880 Grants and Agreements OFFICE OF MANAGEMENT AND... GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Debarment § 180.880 What factors may influence the...

24 CFR 180.660 - Closing of record.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Closing of record. 180.660 Section 180.660 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF... § 180.660 Closing of record. (a) Oral hearings. Where there is an oral hearing, the hearing ends on the...

21 CFR 172.180 - Stannous chloride.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Stannous chloride. 172.180 Section 172.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Food Preservatives § 172.180 Stannous chlorid...

21 CFR 169.180 - Vanilla-vanillin extract.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Vanilla-vanillin extract. 169.180 Section 169.180... Dressings and Flavorings § 169.180 Vanilla-vanillin extract. (a) Vanilla-vanillin extract conforms to the... prescribed for vanilla extract by § 169.175, except that for each unit of vanilla constituent, as defined in...

21 CFR 169.180 - Vanilla-vanillin extract.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Vanilla-vanillin extract. 169.180 Section 169.180... Dressings and Flavorings § 169.180 Vanilla-vanillin extract. (a) Vanilla-vanillin extract conforms to the... prescribed for vanilla extract by § 169.175, except that for each unit of vanilla constituent, as defined in...

21 CFR 169.180 - Vanilla-vanillin extract.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Vanilla-vanillin extract. 169.180 Section 169.180... Dressings and Flavorings § 169.180 Vanilla-vanillin extract. (a) Vanilla-vanillin extract conforms to the... prescribed for vanilla extract by § 169.175, except that for each unit of vanilla constituent, as defined in...

21 CFR 169.180 - Vanilla-vanillin extract.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Vanilla-vanillin extract. 169.180 Section 169.180... Dressings and Flavorings § 169.180 Vanilla-vanillin extract. (a) Vanilla-vanillin extract conforms to the... prescribed for vanilla extract by § 169.175, except that for each unit of vanilla constituent, as defined in...

21 CFR 169.180 - Vanilla-vanillin extract.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Vanilla-vanillin extract. 169.180 Section 169.180... Dressings and Flavorings § 169.180 Vanilla-vanillin extract. (a) Vanilla-vanillin extract conforms to the... prescribed for vanilla extract by § 169.175, except that for each unit of vanilla constituent, as defined in...

46 CFR 180.78 - Stowage of life jackets.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Stowage of life jackets. 180.78 Section 180.78 Shipping...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.78 Stowage of life jackets. (a) General. Unless otherwise stated in this section, life jackets must be stored in convenient places...

46 CFR 180.78 - Stowage of life jackets.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Stowage of life jackets. 180.78 Section 180.78 Shipping...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.78 Stowage of life jackets. (a) General. Unless otherwise stated in this section, life jackets must be stored in convenient places...

46 CFR 180.78 - Stowage of life jackets.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Stowage of life jackets. 180.78 Section 180.78 Shipping...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.78 Stowage of life jackets. (a) General. Unless otherwise stated in this section, life jackets must be stored in convenient places...

26 CFR 1.180-1 - Expenditures by farmers for fertilizer, etc.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Expenditures by farmers for fertilizer, etc. 1.180-1 Section 1.180-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....180-1 Expenditures by farmers for fertilizer, etc. (a) In general. A taxpayer engaged in the business...

12 CFR 516.180 - What procedures govern the conduct of the meeting?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What procedures govern the conduct of the meeting? 516.180 Section 516.180 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Meeting Procedures § 516.180 What procedures govern the conduct...

46 CFR 180.210 - Rescue boats.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Rescue boats. 180.210 Section 180.210 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 180.210 Rescue boats. (a) A vessel of more than 19.8 meters (65 feet) in length must carry at least one rescue boat unless the cognizant...

46 CFR 180.210 - Rescue boats.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Rescue boats. 180.210 Section 180.210 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 180.210 Rescue boats. (a) A vessel of more than 19.8 meters (65 feet) in length must carry at least one rescue boat unless the cognizant...

46 CFR 180.210 - Rescue boats.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Rescue boats. 180.210 Section 180.210 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 180.210 Rescue boats. (a) A vessel of more than 19.8 meters (65 feet) in length must carry at least one rescue boat unless the cognizant...

46 CFR 180.210 - Rescue boats.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Rescue boats. 180.210 Section 180.210 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 180.210 Rescue boats. (a) A vessel of more than 19.8 meters (65 feet) in length must carry at least one rescue boat unless the cognizant...

46 CFR 180.137 - Stowage of life floats and buoyant apparatus.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Stowage of life floats and buoyant apparatus. 180.137... (UNDER 100 GROSS TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.137 Stowage of life floats and buoyant apparatus. (a) In addition to meeting § 180.130, each life...

46 CFR 180.137 - Stowage of life floats and buoyant apparatus.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Stowage of life floats and buoyant apparatus. 180.137... (UNDER 100 GROSS TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.137 Stowage of life floats and buoyant apparatus. (a) In addition to meeting § 180.130, each life...

2 CFR 180.915 - Civil judgment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Civil judgment. 180.915 Section 180.915... § 180.915 Civil judgment. Civil judgment means the disposition of a civil action by any court of... creates a civil liability for the complained of wrongful acts, or a final determination of liability under...

49 CFR 572.190 - Incorporated materials.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Complete; (ix) Drawing No. 180-5000-1, Complete Leg Assembly, Left; (x) Drawing No. 180-5000-2, Complete Leg Assembly, Right; (xi) Drawing No. 180-6000-1, Arm Assembly Left Molded; (xii) Drawing No. 180-6000..., Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590, telephone (202) 366-9826, and at the...

49 CFR 572.190 - Incorporated materials.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Complete; (ix) Drawing No. 180-5000-1, Complete Leg Assembly, Left; (x) Drawing No. 180-5000-2, Complete Leg Assembly, Right; (xi) Drawing No. 180-6000-1, Arm Assembly Left Molded; (xii) Drawing No. 180-6000..., Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590, telephone (202) 366-9826, and at the...

46 CFR 180.75 - Life jacket lights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Life jacket lights. 180.75 Section 180.75 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.75 Life jacket lights. (a) Each... light approved in accordance with § 161.012 in subchapter Q of this chapter, or other standard specified...

46 CFR 180.75 - Life jacket lights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Life jacket lights. 180.75 Section 180.75 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.75 Life jacket lights. (a) Each... light approved in accordance with § 161.012 in subchapter Q of this chapter, or other standard specified...

46 CFR 180.75 - Life jacket lights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Life jacket lights. 180.75 Section 180.75 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.75 Life jacket lights. (a) Each... light approved in accordance with § 161.012 in subchapter Q of this chapter, or other standard specified...

Description of 3,180 courses of chelation with dimercaptosuccinic acid in children ≤ 5 y with severe lead poisoning in Zamfara, Northern Nigeria: a retrospective analysis of programme data.

PubMed

Thurtle, Natalie; Greig, Jane; Cooney, Lauren; Amitai, Yona; Ariti, Cono; Brown, Mary Jean; Kosnett, Michael J; Moussally, Krystel; Sani-Gwarzo, Nasir; Akpan, Henry; Shanks, Leslie; Dargan, Paul I

2014-10-01

In 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo. The US Centers for Disease Control and Prevention (CDC) confirmed widespread contamination from lead-rich ore being processed for gold, and environmental management was begun. MSF commenced a medical management programme that included treatment with the oral chelating agent 2,3-dimercaptosuccinic acid (DMSA, succimer). Here we describe and evaluate the changes in venous blood lead level (VBLL) associated with DMSA treatment in the largest cohort of children ≤ 5 y of age with severe paediatric lead intoxication reported to date to our knowledge. In a retrospective analysis of programme data, we describe change in VBLL after DMSA treatment courses in a cohort of 1,156 children ≤ 5 y of age who underwent between one and 15 courses of chelation treatment. Courses of DMSA of 19 or 28 d duration administered to children with VBLL ≥ 45 µg/dl were included. Impact of DMSA was calculated as end-course VBLL as a percentage of pre-course VBLL (ECP). Mixed model regression with nested random effects was used to evaluate the relative associations of covariates with ECP. Of 3,180 treatment courses administered, 36% and 6% of courses commenced with VBLL ≥ 80 µg/dl and ≥ 120 µg/dl, respectively. Overall mean ECP was 74.5% (95% CI 69.7%-79.7%); among 159 inpatient courses, ECP was 47.7% (95% CI 39.7%-57.3%). ECP after 19-d courses (n = 2,262) was lower in older children, first-ever courses, courses with a longer interval since a previous course, courses with more directly observed doses, and courses with higher pre-course VBLLs. Low haemoglobin was associated with higher ECP. Twenty children aged ≤ 5 y who commenced chelation died during the period studied, with lead poisoning a primary factor in six deaths. Monitoring of alanine transaminase (ALT), creatinine, and full blood count revealed moderate ALT elevation in <2.5% of courses. No clinically severe adverse drug effects were observed, and no laboratory findings required discontinuation of treatment. Limitations include that this was a retrospective analysis of clinical data, and unmeasured variables related to environmental exposures could not be accounted for. Oral DMSA was a pharmacodynamically effective chelating agent for the treatment of severe childhood lead poisoning in a resource-limited setting. Re-exposure to lead, despite efforts to remediate the environment, and non-adherence may have influenced the impact of outpatient treatment. Please see later in the article for the Editors' Summary.

Sequential healing of open extraction sockets. An experimental study in monkeys.

PubMed

Scala, Alessandro; Lang, Niklaus P; Schweikert, Michael T; de Oliveira, José Américo; Rangel-Garcia, Idelmo; Botticelli, Daniele

2014-03-01

To describe the sequential healing of open extraction sockets at which no attempts to obtain a primary closure of the coronal access to the alveolus have been made. The third mandibular premolar was extracted bilaterally in 12 monkeys, and no sutures were applied to close the wound. The healing after 4, 10, 20, 30, 90 and 180 days was morphometrically studied. After 4 days of healing, a blood clot mainly occupied the extraction sockets, with the presence of an inflammatory cells' infiltrate. A void was confined in the central zones of the coronal and middle regions, in continuity with the entrance of the alveoli. At 10 days, the alveolus was occupied by a provisional matrix, with new bone formation lining the socket bony walls. At 20 days, the amount of woven bone was sensibly increasing. At 30 days, the alveolar socket was mainly occupied by mineralized immature bone at different stages of healing. At 90 and 180 days, the amount of mineralized bone decreased and substituted by trabecular bone and bone marrow. Bundle bone decreased from 95.5% at 4 days to 7.6% at 180 days, of the whole length of the inner alveolar surface. Modeling processes start from the lateral and apical walls of the alveolus, leading to the closure of the socket with newly formed bone within a month from extraction. Remodeling processes will follow the previous stages, resulting in trabecular and bone marrow formation and in a corticalization of the socket access. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in rats.

PubMed

Whittaker, Margaret H; Wang, Gensheng; Chen, Xue-Qing; Lipsky, Michael; Smith, Donald; Gwiazda, Roberto; Fowler, Bruce A

2011-07-15

Exposure to chemical mixtures is a common and important determinant of toxicity and is of particular concern due to their appearance in sources of drinking water. Despite this, few in vivo mixture studies have been conducted to date to understand the health impact of chemical mixtures compared to single chemicals. Interactive effects of lead (Pb), cadmium (Cd) and arsenic (As) were evaluated in 30-, 90-, and 180-day factorial design drinking water studies in rats designed to test the hypothesis that ingestion of such mixtures at individual component Lowest-Observed-Effect-Levels (LOELs) results in increased levels of the pro-oxidant delta aminolevulinic acid (ALA), iron, and copper. LOEL levels of Pb, Cd, and As mixtures resulted in the increased presence of mediators of oxidative stress such as ALA, copper, and iron. ALA increases were followed by statistically significant increases in kidney copper in the 90- and 180-day studies. Statistical evidence of interaction was identified for six biologically relevant variables: blood delta aminolevulinic acid dehydratase (ALAD), kidney ALAD, urinary ALA, urinary iron, kidney iron, and kidney copper. The current investigations underscore the importance of considering interactive effects that common toxic agents such as Pb, Cd, and As may have upon one another at low-dose levels. The interactions between known toxic trace elements at biologically relevant concentrations shown here demonstrate a clear need to rigorously review methods by which national/international agencies assess health risks of chemicals, since exposures may commonly occur as complex mixtures. Copyright © 2011. Published by Elsevier Inc.

The rotate-plus-shift C-arm trajectory: complete CT data with limited angular rotation

NASA Astrophysics Data System (ADS)

Ritschl, Ludwig; Kuntz, Jan; Kachelrieß, Marc

2015-03-01

In the last decade C-arm-based cone-beam CT became a widely used modality for intraoperative imaging. Typically a C-arm scan is performed using a circle-like trajectory around a region of interest. Therefor an angular range of at least 180° plus fan-angle must be covered to ensure a completely sampled data set. This fact defines some constraints on the geometry and technical specifications of a C-arm system, for example a larger C radius or a smaller C opening respectively. These technical modifications are usually not beneficial in terms of handling and usability of the C-arm during classical 2D applications like fluoroscopy. The method proposed in this paper relaxes the constraint of 180° plus fan-angle rotation to acquire a complete data set. The proposed C-arm trajectory requires a motorization of the orbital axis of the C and of ideally two orthogonal axis in the C plane. The trajectory consists of three parts: A rotation of the C around a defined iso-center and two translational movements parallel to the detector plane at the begin and at the end of the rotation. Combining these three parts to one trajectory enables for the acquisition of a completely sampled dataset using only 180° minus fan-angle of rotation. To evaluate the method we show animal and cadaver scans acquired with a mobile C-arm prototype. We expect that the transition of this method into clinical routine will lead to a much broader use of intraoperative 3D imaging in a wide field of clinical applications.

A Class II small heat shock protein OsHsp18.0 plays positive roles in both biotic and abiotic defense responses in rice.

PubMed

Kuang, Jie; Liu, Jianzhong; Mei, Jun; Wang, Changchun; Hu, Haitao; Zhang, Yanjun; Sun, Meihao; Ning, Xi; Xiao, Langtao; Yang, Ling

2017-09-12

Bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most devastating diseases of rice. However, the molecular mechanism underpinning the Xoo resistance of rice is still not fully understood. Here, we report that a class II small heat shock protein gene, OsHsp18.0, whose expression was differentially induced between a resistant and a susceptible variety in response to Xoo infection, plays positive roles in both biotic and abiotic resistance. The molecular chaperone activity of OsHsp18.0 was confirmed by a bacterium-expressed glutathione S-transferase fusion protein. Overexpression of OsHsp18.0 in a susceptible rice variety significantly enhanced its resistance to multiple Xoo strains, whereas silencing of OsHsp18.0 in a resistant variety drastically increased its susceptibility. The enhanced Xoo resistance in OsHsp18.0-overexpressing lines was positively correlated with the sensitized salicylic acid-dependent defense responses. In addition to disease resistance, the OsHsp18.0 overexpressing and silencing lines exhibited enhanced and reduced tolerance, respectively, to heat and salt treatments. The subcellular localization study revealed that the green fluorescent protein-OsHsp18.0 was enriched on the nuclear envelope, suggesting a potential role of OsHsp18.0 in the nucleo-cytoplasmic trafficking. Together, our results reveal that the rice OsHsp18.0 is a positive regulator in both biotic and abiotic defense responses.

27 CFR 53.180 - Tax-paid articles used for further manufacture and causing overpayments of tax.

Code of Federal Regulations, 2010 CFR

2010-04-01

... further manufacture and causing overpayments of tax. 53.180 Section 53.180 Alcohol, Tobacco Products and... Application to Manufacturers Taxes § 53.180 Tax-paid articles used for further manufacture and causing... manufacture of a second article or who sells the article with, or as a part of, the second article...

46 CFR 180.71 - Life jackets.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided, or...

46 CFR 180.71 - Life jackets.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided, or...

21 CFR 160.180 - Egg yolks.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Egg yolks. 160.180 Section 160.180 Food and Drugs... CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.180 Egg yolks. (a) Egg yolks, liquid egg yolks, yolks, liquid yolks are yolks of eggs of the domestic hen so...

40 CFR 180.1279 - Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance. 180.1279 Section 180.1279 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1279 Zucchini yellow mosaic virus—weak...

40 CFR 180.1279 - Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance. 180.1279 Section 180.1279 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1279 Zucchini yellow mosaic virus—weak...

40 CFR 180.1279 - Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance. 180.1279 Section 180.1279 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1279 Zucchini yellow mosaic virus—weak...

40 CFR 180.1279 - Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance. 180.1279 Section 180.1279 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1279 Zucchini yellow mosaic virus—weak...

40 CFR 180.1279 - Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Zucchini yellow mosaic virus-weak strain; exemption from the requirement of a tolerance. 180.1279 Section 180.1279 Protection of... PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1279 Zucchini yellow mosaic virus—weak...

40 CFR 180.1049 - Carbon dioxide; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Carbon dioxide; exemption from the requirement of a tolerance. 180.1049 Section 180.1049 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1049 Carbo...

40 CFR 180.1049 - Carbon dioxide; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Carbon dioxide; exemption from the requirement of a tolerance. 180.1049 Section 180.1049 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1049 Carbo...

40 CFR 180.1049 - Carbon dioxide; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Carbon dioxide; exemption from the requirement of a tolerance. 180.1049 Section 180.1049 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1049 Carbo...

2 CFR 180.530 - Where can I find the EPLS?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Where can I find the EPLS? 180.530 Section 180.530 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND...) Excluded Parties List System § 180.530 Where can I find the EPLS? You may access the EPLS through the...

40 CFR 180.129 - o-Phenylphenol and its sodium salt; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false o-Phenylphenol and its sodium salt; tolerances for residues. 180.129 Section 180.129 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.129 o-Phenylphenol an...

2 CFR 180.325 - What happens if I do business with an excluded person in a covered transaction?

Code of Federal Regulations, 2010 CFR

2010-01-01

... person, the Federal agency responsible for your transaction may disallow costs, annul or terminate the... excluded person in a covered transaction? 180.325 Section 180.325 Grants and Agreements OFFICE OF... Regarding Transactions Doing Business With Other Persons § 180.325 What happens if I do business with an...

21 CFR 133.180 - Pasteurized process cheese spread with fruits, vegetables, or meats.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., vegetables, or meats. 133.180 Section 133.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Requirements for Specific Standardized Cheese and Related Products § 133.180 Pasteurized process cheese spread... spread by § 133.179, except that: (1) It contains one or any mixture of two or more of the following: Any...

40 CFR 180.1285 - Polyoxin D zinc salt; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Polyoxin D zinc salt; exemption from the requirement of a tolerance. 180.1285 Section 180.1285 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1285...

40 CFR 180.1285 - Polyoxin D zinc salt; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Polyoxin D zinc salt; exemption from the requirement of a tolerance. 180.1285 Section 180.1285 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1285...

40 CFR 180.1285 - Polyoxin D zinc salt; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Polyoxin D zinc salt; exemption from the requirement of a tolerance. 180.1285 Section 180.1285 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1285...

41 CFR 102-117.180 - What transportation documents must I use to ship freight?

Code of Federal Regulations, 2011 CFR

2011-01-01

... documents must I use to ship freight? 102-117.180 Section 102-117.180 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.180 What transportation documents must I use to ship freight? To ship freight: (a) By land (domestic shipments), use a bill of lading; (b) By...

41 CFR 102-117.180 - What transportation documents must I use to ship freight?

Code of Federal Regulations, 2013 CFR

2013-07-01

... documents must I use to ship freight? 102-117.180 Section 102-117.180 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.180 What transportation documents must I use to ship freight? To ship freight: (a) By land (domestic shipments), use a bill of lading; (b) By...

41 CFR 102-117.180 - What transportation documents must I use to ship freight?

Code of Federal Regulations, 2010 CFR

2010-07-01

... documents must I use to ship freight? 102-117.180 Section 102-117.180 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.180 What transportation documents must I use to ship freight? To ship freight: (a) By land (domestic shipments), use a bill of lading; (b) By...

41 CFR 102-117.180 - What transportation documents must I use to ship freight?

Code of Federal Regulations, 2014 CFR

2014-01-01

... documents must I use to ship freight? 102-117.180 Section 102-117.180 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.180 What transportation documents must I use to ship freight? To ship freight: (a) By land (domestic shipments), use a bill of lading; (b) By...

41 CFR 102-117.180 - What transportation documents must I use to ship freight?

Code of Federal Regulations, 2012 CFR

2012-01-01

... documents must I use to ship freight? 102-117.180 Section 102-117.180 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.180 What transportation documents must I use to ship freight? To ship freight: (a) By land (domestic shipments), use a bill of lading; (b) By...

46 CFR 180.207 - Survival craft-vessels operating on lakes, bays, and sounds routes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... sounds routes. 180.207 Section 180.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Survival Craft § 180.207 Survival craft—vessels operating on lakes, bays, and sounds routes. (a) Except as... operate on a lakes, bays, and sounds route in cold water must either: (1) Be provided with life floats of...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

21 CFR 137.180 - Self-rising flour.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Self-rising flour. 137.180 Section 137.180 Food... Flours and Related Products § 137.180 Self-rising flour. (a) Self-rising flour, self-rising white flour, self-rising wheat flour, is an intimate mixture of flour, sodium bicarbonate, and one or more of the...

46 CFR 180.71 - Life jackets.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided, or...

46 CFR 180.71 - Life jackets.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided, or...

46 CFR 180.71 - Life jackets.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Life jackets. 180.71 Section 180.71 Shipping COAST GUARD... EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.71 Life jackets. (a) An adult life jacket... life jackets equal to at least 10% of the number of persons permitted on board must be provided, or...

46 CFR 180.207 - Survival craft-vessels operating on lakes, bays, and sounds routes.

Code of Federal Regulations, 2012 CFR

2012-10-01

... sounds routes. 180.207 Section 180.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Survival Craft § 180.207 Survival craft—vessels operating on lakes, bays, and sounds routes. (a) Except as... operate on a lakes, bays, and sounds route in cold water must either: (1) Be provided with life floats of...

46 CFR 180.207 - Survival craft-vessels operating on lakes, bays, and sounds routes.

Code of Federal Regulations, 2013 CFR

2013-10-01

... sounds routes. 180.207 Section 180.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Survival Craft § 180.207 Survival craft—vessels operating on lakes, bays, and sounds routes. (a) Except as... operate on a lakes, bays, and sounds route in cold water must either: (1) Be provided with life floats of...

46 CFR 180.207 - Survival craft-vessels operating on lakes, bays, and sounds routes.

Code of Federal Regulations, 2014 CFR

2014-10-01

... sounds routes. 180.207 Section 180.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Survival Craft § 180.207 Survival craft—vessels operating on lakes, bays, and sounds routes. (a) Except as... operate on a lakes, bays, and sounds route in cold water must either: (1) Be provided with life floats of...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

24 CFR 180.415 - Notice of proposed adverse action regarding Federal financial assistance in non-Fair Housing Act...

Code of Federal Regulations, 2010 CFR

2010-04-01

... regarding Federal financial assistance in non-Fair Housing Act matters. 180.415 Section 180.415 Housing and... CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Proceedings Prior to Hearing § 180.415 Notice of proposed adverse action regarding Federal financial assistance in non-Fair Housing Act matters. (a) Filing...

29 CFR 4.180 - Overtime pay-in general.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Overtime pay-in general. 4.180 Section 4.180 Labor Office of... Pay of Covered Employees § 4.180 Overtime pay—in general. The Act does not provide for compensation of... follows: “In determining any overtime pay to which such service employees are entitled under any Federal...

21 CFR 160.180 - Egg yolks.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Egg yolks. 160.180 Section 160.180 Food and Drugs... CONSUMPTION EGGS AND EGG PRODUCTS Requirements for Specific Standardized Eggs and Egg Products § 160.180 Egg yolks. (a) Egg yolks, liquid egg yolks, yolks, liquid yolks are yolks of eggs of the domestic hen so...

46 CFR 180.207 - Survival craft-vessels operating on lakes, bays, and sounds routes.

Code of Federal Regulations, 2011 CFR

2011-10-01

... sounds routes. 180.207 Section 180.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Survival Craft § 180.207 Survival craft—vessels operating on lakes, bays, and sounds routes. (a) Except as... operate on a lakes, bays, and sounds route in cold water must either: (1) Be provided with life floats of...

Study on the growth mechanism and optical properties of sputtered lead selenide thin films

NASA Astrophysics Data System (ADS)

Sun, Xigui; Gao, Kewei; Pang, Xiaolu; Yang, Huisheng; Volinsky, Alex A.

2015-11-01

Lead selenide thin films with different microstructure were deposited on Si (1 0 0) substrates using magnetron sputtering at 50 °C, 150 °C and 250 °C, respectively. The crystal structure of the sputtered PbSe thin films varies from amorphous crystalline to columnar grain, and then to double-layer (nano-crystalline layer and columnar grain layer) structure as the deposition temperature increases, which is due to the dominating growth mode of the thin films changes from Frank-van der Merwe (or layer-by-layer) growth mode at 50 °C to Volmer-Weber (or 3D island) growth mode at 150 °C, and then to Stranski-Krastanow (or 3D island-on-wetting-layer) growth mode at 250 °C. The growth mechanism of the sputtered PbSe thin films is mainly dominated by the surface and strain energy contributions. Moreover, the strain energy contribution is more prominent when the deposition temperature is less than 180 °C, while, the surface energy contribution is more prominent when the deposition temperature is higher than 180 °C. The absorption spectra of the sputtered PbSe thin films are in 3.1-5 μm range. Besides, the sputtered PbSe thin film prepared at 250 °C has two different optical band gaps due to its unique double-layer structure. According to the theoretical calculation results, the variation of the band gap with the deposition temperature is determined by the shift of the valence band maximum with the lattice constant.

Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects.

PubMed

Barbosa, Fernando; Corrêa Rodrigues, Maria Heloísa; Buzalaf, Maria R; Krug, Francisco J; Gerlach, Raquel F; Tanus-Santos, José Eduardo

2006-10-01

We conducted a study to evaluate the use of parotid salivary lead (Pb-saliva) levels as a surrogate of the blood lead (Pb-B) or plasma lead levels (Pb-P) to diagnose lead exposure. The relationship between these biomarkers was assessed in a lead exposed population. Pb-saliva and Pb-P were determined by inductively coupled plasma mass spectrometry, while in whole blood lead was determined by graphite furnace atomic absorption spectrometry. We studied 88 adults (31 men and 57 women) from 18 to 60 years old. Pb-saliva levels varied from 0.05 to 4.4 microg/l, with a mean of 0.85 microg/l. Blood lead levels varied from 32.0 to 428.0 microg/l in men (mean 112.3 microg/l) and from 25.0 to 263.0 microg/l (mean 63.5 microg/l) in women. Corresponding Pb-Ps were 0.02-2.50 microg/l (mean 0.77 microg/l) and 0.03-1.6 microg/l (mean 0.42 microg/l) in men and women, respectively. A weak correlation was found between Log Pb-saliva and Log Pb-B (r=0.277, P<0.008), and between Log Pb-saliva and Log Pb-P (r=0.280, P=0.006). The Pb-saliva/Pb-P ratio ranged from 0.20 to 18.0. Age or gender does not affect Pb-saliva levels or Pb-saliva/Pb-P ratio. Taken together, these results suggest that salivary lead may not be used as a biomarker to diagnose lead exposure nor as a surrogate of plasma lead levels at least for low to moderately lead exposed population.

Integrated circuit cooled turbine blade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ching-Pang; Jiang, Nan; Um, Jae Y.

A turbine rotor blade includes at least two integrated cooling circuits that are formed within the blade that include a leading edge circuit having a first cavity and a second cavity and a trailing edge circuit that includes at least a third cavity located aft of the second cavity. The trailing edge circuit flows aft with at least two substantially 180-degree turns at the tip end and the root end of the blade providing at least a penultimate cavity and a last cavity. The last cavity is located along a trailing edge of the blade. A tip axial cooling channelmore » connects to the first cavity of the leading edge circuit and the penultimate cavity of the trailing edge circuit. At least one crossover hole connects the penultimate cavity to the last cavity substantially near the tip end of the blade.« less

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

PubMed

Lu, Mingjian; Kinchen, Jason M; Rossman, Kent L; Grimsley, Cynthia; Hall, Matthew; Sondek, John; Hengartner, Michael O; Yajnik, Vijay; Ravichandran, Kodi S

2005-02-22

CDM (CED-5, Dock180, Myoblast city) family members have been recently identified as novel, evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases . They regulate multiple processes, including embryonic development, cell migration, apoptotic-cell engulfment, tumor invasion, and HIV-1 infection, in diverse model systems . However, the mechanism(s) of regulation of CDM proteins has not been well understood. Here, our studies on the prototype member Dock180 reveal a steric-inhibition model for regulating the Dock180 family of GEFs. At basal state, the N-terminal SH3 domain of Dock180 binds to the distant catalytic Docker domain and negatively regulates the function of Dock180. Further studies revealed that the SH3:Docker interaction sterically blocks Rac access to the Docker domain. Interestingly, ELMO binding to the SH3 domain of Dock180 disrupted the SH3:Docker interaction, facilitated Rac access to the Docker domain, and contributed to the GEF activity of the Dock180/ELMO complex. Additional genetic rescue studies in C. elegans suggested that the regulation of the Docker-domain-mediated GEF activity by the SH3 domain and its adjoining region is evolutionarily conserved. This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes.

2 CFR 180.360 - What happens if I fail to disclose information required under § 180.355?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What happens if I fail to disclose... With Other Persons Disclosing Information-Lower Tier Participants § 180.360 What happens if I fail to disclose information required under § 180.355? If a Federal agency later determines that you failed to tell...

2 CFR 180.345 - What happens if I fail to disclose information required under § 180.335?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What happens if I fail to disclose... With Other Persons Disclosing Information-Primary Tier Participants § 180.345 What happens if I fail to disclose information required under § 180.335? If a Federal agency later determines that you failed to...

2 CFR 180.360 - What happens if I fail to disclose information required under § 180.355?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false What happens if I fail to disclose... With Other Persons Disclosing Information-Lower Tier Participants § 180.360 What happens if I fail to disclose information required under § 180.355? If a Federal agency later determines that you failed to tell...

2 CFR 180.345 - What happens if I fail to disclose information required under § 180.335?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false What happens if I fail to disclose... With Other Persons Disclosing Information-Primary Tier Participants § 180.345 What happens if I fail to disclose information required under § 180.335? If a Federal agency later determines that you failed to...

41 CFR 102-73.180 - What types of special purpose space may the Department of Defense lease?

Code of Federal Regulations, 2013 CFR

2013-07-01

... purpose space may the Department of Defense lease? 102-73.180 Section 102-73.180 Public Contracts and... § 102-73.180 What types of special purpose space may the Department of Defense lease? The Department of Defense is delegated authority to lease the following types of special purpose space: (a) Air Force—Civil...

41 CFR 102-73.180 - What types of special purpose space may the Department of Defense lease?

Code of Federal Regulations, 2014 CFR

2014-01-01

... purpose space may the Department of Defense lease? 102-73.180 Section 102-73.180 Public Contracts and... § 102-73.180 What types of special purpose space may the Department of Defense lease? The Department of Defense is delegated authority to lease the following types of special purpose space: (a) Air Force—Civil...

41 CFR 102-73.180 - What types of special purpose space may the Department of Defense lease?

Code of Federal Regulations, 2010 CFR

2010-07-01

... purpose space may the Department of Defense lease? 102-73.180 Section 102-73.180 Public Contracts and... § 102-73.180 What types of special purpose space may the Department of Defense lease? The Department of Defense is delegated authority to lease the following types of special purpose space: (a) Air Force—Civil...

41 CFR 102-73.180 - What types of special purpose space may the Department of Defense lease?

Code of Federal Regulations, 2012 CFR

2012-01-01

... purpose space may the Department of Defense lease? 102-73.180 Section 102-73.180 Public Contracts and... § 102-73.180 What types of special purpose space may the Department of Defense lease? The Department of Defense is delegated authority to lease the following types of special purpose space: (a) Air Force—Civil...

41 CFR 102-73.180 - What types of special purpose space may the Department of Defense lease?

Code of Federal Regulations, 2011 CFR

2011-01-01

... purpose space may the Department of Defense lease? 102-73.180 Section 102-73.180 Public Contracts and... § 102-73.180 What types of special purpose space may the Department of Defense lease? The Department of Defense is delegated authority to lease the following types of special purpose space: (a) Air Force—Civil...

40 CFR 180.341 - 2,4-Dinitro-6-octylphenyl crotonate and 2,6-dinitro-4-octylphenyl crotonate; tolerances for...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false 2,4-Dinitro-6-octylphenyl crotonate and 2,6-dinitro-4-octylphenyl crotonate; tolerances for residues. 180.341 Section 180.341 Protection... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.341 2,4-Dinitro-6-octylphenyl...

46 CFR 180.70 - Ring life buoys.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Ring life buoys. 180.70 Section 180.70 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.70 Ring life buoys. (a) A vessel must have one or more ring life buoys as follows: (1) A vessel of not more than 7.9 meters (26 feet) in...

46 CFR 180.70 - Ring life buoys.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Ring life buoys. 180.70 Section 180.70 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.70 Ring life buoys. (a) A vessel must have one or more ring life buoys as follows: (1) A vessel of not more than 7.9 meters (26 feet) in...

76 FR 36316 - Safety Zone; Upper Mississippi River, Mile 180.0 to 179.0

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

...-AA00 Safety Zone; Upper Mississippi River, Mile 180.0 to 179.0 AGENCY: Coast Guard, DHS. ACTION... Upper Mississippi River, from Mile 180.0 to 179.0, extending the entire width of the river. This safety... combat capabilities between Mile 180.0 and 179.0 on the Upper Mississippi River. This event presents...

2 CFR 180.205 - Why is it important if a particular transaction is a covered transaction?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Why is it important if a particular transaction is a covered transaction? 180.205 Section 180.205 Grants and Agreements OFFICE OF MANAGEMENT AND... § 180.415; or (2) A Federal agency official obtains an exception from the agency head or designee to...

40 CFR 180.1167 - Allyl isothiocyanate as a component of food grade oil of mustard; exemption from the requirement...

Code of Federal Regulations, 2011 CFR

2011-07-01

... used as a component of food grade oil of mustard, in or on all raw agricultural commodities, when... food grade oil of mustard; exemption from the requirement of a tolerance. 180.1167 Section 180.1167... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions From Tolerances § 180.1167 Allyl isothiocyanate...

41 CFR 102-3.180 - What does this subpart cover and how does it apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... by the National Academy of Sciences or the National Academy of Public Administration? § 102-3.180... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does this subpart cover and how does it apply? 102-3.180 Section 102-3.180 Public Contracts and Property Management...

49 CFR 180.519 - Periodic retest and inspection of tank cars other than single-unit tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Periodic retest and inspection of tank cars other than single-unit tank car tanks. 180.519 Section 180.519 Transportation Other Regulations Relating to... of Tank Cars § 180.519 Periodic retest and inspection of tank cars other than single-unit tank car...

40 CFR 180.123a - Inorganic bromide residues in peanut hay and peanut hulls; statement of policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Inorganic bromide residues in peanut hay and peanut hulls; statement of policy. 180.123a Section 180.123a Protection of Environment... RESIDUES IN FOOD Specific Tolerances § 180.123a Inorganic bromide residues in peanut hay and peanut hulls...

46 CFR 180.70 - Ring life buoys.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Ring life buoys. 180.70 Section 180.70 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.70 Ring life buoys. (a) A vessel must have one or more ring life buoys as follows: (1) A vessel of not more than 7.9 meters (26 feet) in...

46 CFR 180.70 - Ring life buoys.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Ring life buoys. 180.70 Section 180.70 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.70 Ring life buoys. (a) A vessel must have one or more ring life buoys as follows: (1) A vessel of not more than 7.9 meters (26 feet) in...

46 CFR 180.70 - Ring life buoys.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Ring life buoys. 180.70 Section 180.70 Shipping COAST...) LIFESAVING EQUIPMENT AND ARRANGEMENTS Ring Life Buoys and Life Jackets § 180.70 Ring life buoys. (a) A vessel must have one or more ring life buoys as follows: (1) A vessel of not more than 7.9 meters (26 feet) in...

40 CFR 180.483 - O-[2-(1,1-Dimethylethyl)-5-pyrimidinyl] O-ethyl-O-(1-methyl-ethyl) phosphorothioate; tolerances...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false O-[2-(1,1-Dimethylethyl)-5-pyrimidinyl] O-ethyl-O-(1-methyl-ethyl) phosphorothioate; tolerances for residues. 180.483 Section 180.483... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.483 O-[2-(1,1-Dimethylethyl)-5...

2 CFR 180.320 - Must I verify that principals of my covered transactions are eligible to participate?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Must I verify that principals of my covered transactions are eligible to participate? 180.320 Section 180.320 Grants and Agreements OFFICE OF MANAGEMENT... Doing Business With Other Persons § 180.320 Must I verify that principals of my covered transactions are...

Survival of nature's rarest isotope {sup 180}Ta under stellar conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohr, P.; Kaeppeler, F.; Gallino, R.

2007-01-15

The nucleosynthesis of nature's rarest isotope {sup 180}Ta depends sensitively on the temperature of the astrophysical environment because of depopulation of the long-living isomeric state via intermediate states to the short-living ground state by thermal photons. Reaction rates for this transition have been measured in the laboratory. These ground state rates underestimate the stellar rates dramatically because under stellar conditions intermediate states are mainly populated by excitations from thermally excited states in {sup 180m}Ta. Full thermalization of {sup 180}Ta is already achieved for typical s-process temperatures around kT=25 keV. Consequently, for the survival of {sup 180}Ta in the s-process fastmore » convective mixing is required which has to transport freshly synthesized {sup 180}Ta to cooler regions. In supernova explosions {sup 180}Ta is synthesized by photon- or neutrino-induced reactions at temperatures above T{sub 9}=1 in thermal equilibrium; independent of the production mechanism, freeze-out from thermal equilibrium occurs at kT{approx_equal}40 keV, and only 35{+-}4% of the synthesized {sup 180}Ta survive in the isomeric state.« less

2 CFR 180.345 - What happens if I fail to disclose information required under § 180.335?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What happens if I fail to disclose... happens if I fail to disclose information required under § 180.335? If a Federal agency later determines that you failed to disclose information under § 180.335 that you knew at the time you entered into the...

2 CFR 1400.970 - Nonprocurement transaction (Department of the Interior supplement to the definition at 2 CFR 180...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Nonprocurement transaction (Department of the Interior supplement to the definition at 2 CFR 180.970). 1400.970 Section 1400.970 Grants and... supplement to the definition at 2 CFR 180.970). In addition to those listed in 2 CFR 180.970, the Department...

49 CFR Appendix B to Part 180 - Acceptable Internal Self-closing Stop Valve Leakage Tests for Cargo Tanks Transporting Liquefied...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Leakage Tests for Cargo Tanks Transporting Liquefied Compressed Gases B Appendix B to Part 180... Pt. 180, App. B Appendix B to Part 180—Acceptable Internal Self-closing Stop Valve Leakage Tests for.... (b) Internal Self-Closing Stop Valve Test. An operator of a cargo tank that is not equipped with a...

33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Naval Mine Warfare Test Station, or of U.S. Naval Air Station property. A person in the water or a... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable... REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Naval Mine Warfare Test Station, or of U.S. Naval Air Station property. A person in the water or a... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable... REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Naval Mine Warfare Test Station, or of U.S. Naval Air Station property. A person in the water or a... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable... REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Naval Mine Warfare Test Station, or of U.S. Naval Air Station property. A person in the water or a... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable... REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Naval Mine Warfare Test Station, or of U.S. Naval Air Station property. A person in the water or a... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable... REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

Reversal effect and mechanism of Ginkgo biloba exocarp extracts in multidrug resistance of mice S180 tumor cells

PubMed Central

Hu, Bi-Yuan; Gu, Yun-Hao; Cao, Chen-Jie; Wang, Jun; Han, Dong-Dong; Tang, Ying-Chao; Chen, Hua-Sheng; Xu, Aihua

2016-01-01

The aim of the present study was to investigate the reversal effect and its related mechanism of Ginkgo biloba exocarp extracts (GBEEs) in obtained multidrug resistance (MDR) of mice S180 tumor cells in vitro and in vivo. In order to simulate the clinical PFC [cis-dichlorodiamineplatinum, cisplatin (DDP) + fluorouracil (FU), FU+cyclophosphamide and cyclophosphamide] scheme, a gradually increasing dose was administered in a phased induction in order to induce S180 cells in vivo and to make them obtain multidrug resistance. The results in vitro demonstrated that GBEE could significantly increase the IC50 of DDP on S180 MDR cells, increase the accumulation of Adriamycin (ADR) and rhodamine 123 (Rho 123), and reduce the efflux of Rho 123 of S180 MDR cells. The results from the in vivo treatment with a combination of GBEE and DDP to S180 MDR ascites tumor in mice demonstrated that each dose of GBEE could effectively reverse the drug-resistance of S180 MDR cells to DDP in order to extend the survival time of mice with ascite tumors and inhibit tumor growth in solid tumor mice. In addition, GBEE effectively inhibited the expression of MDR-1 mRNA and multidrug resistance-associated protein-1 mRNA in S180 MDR cells of ascites tumor in mice and improved the expression levels of cytokines, including interleukin (IL)-3, IL-18 and interferon-γ in the blood serum of S180 MDR tumor-bearing mice. The present study showed that the mechanism of GBEE reversal of MDR may be associated with the inhibition of the functional activity of P-glycoprotein, the downregulation of drug resistance related gene expression of S180 MDR cells and the improvement of the production of related serum cytokines of S180 MDR tumor mice. PMID:27698692

Laparoscopic Nissen (total) versus anterior 180° fundoplication for gastro-esophageal reflux disease

PubMed Central

Du, Xing; Wu, Ji-Min; Hu, Zhi-Wei; Wang, Feng; Wang, Zhong-Gao; Zhang, Chao; Yan, Chao; Chen, Mei-Ping

2017-01-01

Abstract Background: Laparoscopic Nissen fundoplication (LNF) has been the gold standard for the surgical management of Gastro-esophageal reflux disease (GERD). Laparoscopic anterior 180° fundoplication (180° LAF) is reported to reduce the incidence of postoperative complications while obtaining similar control of reflux. The present meta-analysis was conducted to confirm the value of the 2 techniques. Methods: PubMed, Medline, Embase, Cochrane Library, Springerlink, and China National Knowledge Infrastructure Platform databases were searched for randomized controlled trials (RCTs) comparing LNF and 180° LAF. Data regarding the benefits and adverse results of 2 techniques were extracted and compared using a meta-analysis. Results: Six eligible RCTs comparing LNF (n = 266) and 180° LAF (n = 265) were identified. There were no significant differences between LNF and 180° LAF with regard to operating time, perioperative complications, length of hospital stay, patient satisfaction, willingness to undergo surgery again, quality of life, postoperative heartburn, proton pump inhibitor (PPI) use, postoperative DeMeester scores, postoperative lower esophageal sphincter (LES) pressure, postoperative gas-bloating, unable to belch, diarrhea, or overall reoperation. LNF was associated with a higher prevalence of postoperative dysphagia compared with 180° LAF, while 180° LAF was followed by more reoperation for recurrent reflux symptoms. Conclusion: LNF and 180° LAF are equally effective in controlling reflux symptoms and obtain a comparable prevalence of patient satisfaction. 180° LAF can reduce the incidence of postoperative dysphagia while this is offset by a higher risk of reoperation for recurrent symptoms. The risk of recurrent symptoms should need to be balanced against the risk of dysphagia when surgeons choose surgical procedures for each individual with GERD. PMID:28906412

Laparoscopic Nissen (total) versus anterior 180° fundoplication for gastro-esophageal reflux disease: A meta-analysis and systematic review.

PubMed

Du, Xing; Wu, Ji-Min; Hu, Zhi-Wei; Wang, Feng; Wang, Zhong-Gao; Zhang, Chao; Yan, Chao; Chen, Mei-Ping

2017-09-01

Laparoscopic Nissen fundoplication (LNF) has been the gold standard for the surgical management of Gastro-esophageal reflux disease (GERD). Laparoscopic anterior 180° fundoplication (180° LAF) is reported to reduce the incidence of postoperative complications while obtaining similar control of reflux. The present meta-analysis was conducted to confirm the value of the 2 techniques. PubMed, Medline, Embase, Cochrane Library, Springerlink, and China National Knowledge Infrastructure Platform databases were searched for randomized controlled trials (RCTs) comparing LNF and 180° LAF. Data regarding the benefits and adverse results of 2 techniques were extracted and compared using a meta-analysis. Six eligible RCTs comparing LNF (n = 266) and 180° LAF (n = 265) were identified. There were no significant differences between LNF and 180° LAF with regard to operating time, perioperative complications, length of hospital stay, patient satisfaction, willingness to undergo surgery again, quality of life, postoperative heartburn, proton pump inhibitor (PPI) use, postoperative DeMeester scores, postoperative lower esophageal sphincter (LES) pressure, postoperative gas-bloating, unable to belch, diarrhea, or overall reoperation. LNF was associated with a higher prevalence of postoperative dysphagia compared with 180° LAF, while 180° LAF was followed by more reoperation for recurrent reflux symptoms. LNF and 180° LAF are equally effective in controlling reflux symptoms and obtain a comparable prevalence of patient satisfaction. 180° LAF can reduce the incidence of postoperative dysphagia while this is offset by a higher risk of reoperation for recurrent symptoms. The risk of recurrent symptoms should need to be balanced against the risk of dysphagia when surgeons choose surgical procedures for each individual with GERD.

Could some procedures commonly used in bioassays with the copepod Acartia tonsa Dana 1849 distort results?

PubMed

Lopes, Laís Fernanda de Palma; Agostini, Vanessa Ochi; Muxagata, Erik

2018-04-15

Many organizations have suggested the use of the Calanoid copepod Acartia tonsa in protocols for acute toxicity tests. Nevertheless, these protocols present some problems, such as using 60-180µm meshes to separate specific stages of A. tonsa or carrying out the tests using small volumes that reflect high densities of A. tonsa that do not occur in nature, which could lead to distorted results. In addition, ecotoxicological studies may use statistical approaches that are inadequate for the type of data being analysed. For these reasons, some methodological approaches for bioassays using A. tonsa need to be clarified and revised. In this study, we present information about (i) the retention of copepodite stages of A. tonsa on 180, 330 and 500µm net meshes; (ii) tested storage volumes of 1 organism per 5, 10 or 20mL in each test container (TC); and (iii) considerations about the statistics employed. The results demonstrated that a net mesh of 180µm is capable of retaining all copepodite stages (CI to CVI), contrasting with the recommendation of using a 180µm mesh to separate out adults only. Coarser meshes (330 and 500µm) can also retain different proportions of all copepodite stages, but cannot separate out one developmental stage only. Twenty-five millilitres of medium in an open TC, commonly employed in bioassays simulating densities of 1 organism 5mL -1 , completely evaporated, and the results showed that the TCs need to be covered (e.g., PVC film) and filled with a minimum of 100mL of culture medium (simulating densities of 1 organism 20mL -1 ) to avoid evaporation and increases in salinity. The current use of ANOVA in ecotoxicological studies with proportions of surviving organisms should also be reconsidered since the data are discrete and have a binomial distribution; general linear models (GLMs) are considered more adequate. The information presented here suggests some adjustments that hopefully will enable the improvement of the procedures and methods employed in studies of acute toxicity using the copepod A. tonsa. Copyright © 2017 Elsevier Inc. All rights reserved.

Incretin effects, gastric emptying and insulin responses to low oral glucose loads in patients after gastric bypass and lean and obese controls.

PubMed

Wölnerhanssen, Bettina K; Meyer-Gerspach, Anne Christin; Peters, Thomas; Beglinger, Christoph; Peterli, Ralph

2016-08-01

After laparoscopic Roux-en-Y gastric bypass (LRYGB), many patients suffer from dumping syndrome. Oral glucose tolerance tests are usually carried out with 50-75 g of glucose. The aim of this study was to examine whether minimal glucose loads of 10 g and 25 g induce a reliable secretion of satiation peptides without dumping symptoms after LRYGB. In addition, lean and obese controls were examined. The objective of this study was to determine the effects of low oral glucose loads on incretin release and gastric emptying. All surgical procedures were performed by the same surgeon (RP) at the St. Claraspital Basel in Switzerland. Oral glucose challenges were carried out at the University Hospital of Basel (Phase 1 Research Unit). Eight patients 10±.4 weeks after LRYGB (PostOP; body mass index [BMI]: 38.6 kg/m 2 ±1.7) as well as 12 lean controls (LC; BMI: 21.8 kg/m 2 ±.6) and 12 obese controls (OC; BMI 38.7 kg/m 2 ±1.3) received 10 g and 25 g of oral glucose. We examined clinical signs of dumping syndrome; plasma glucose, insulin, glucagon-like peptide 1, glucose-dependent insulinotropic peptide, and peptide tyrosine tyrosine concentrations; and gastric emptying with a 13 C-sodium acetate breath test. No signs of dumping were seen in PostOP. Compared with OC, LC showed lower fasting glucose, insulin, and C-peptide, and lower homeostasis model assessment (HOMA) and AUC-180 for insulin and C-peptide. In PostOP, fasting insulin, HOMA and AUC-180 for insulin was lower and no difference was found in fasting C-peptide or AUC-180 for C-peptide compared to OC. There was no significant difference in fasting glucose, insulin, C-peptide, HOMA and AUC-180 for insulin in PostOP compared to LC, but AUC-180 for C-peptide was higher in PostOP. AUC-60 for gut hormones was similar in OC and LC and higher in PostOP compared to OC or LC. gastric emptying was slower in LC and OC compared with PostOP. After LRYGB, 25 g oral glucose is well tolerated and leads to reliable secretion of gut hormones. Fasting glucose, insulin and C-peptide are normalized, while glucagon-like peptide 1, glucose-dependent insulinotropic peptide and peptide tyrosine tyrosine are overcorrected. Pouch emptying is accelerated after LRYGB. Copyright © 2016 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

Lower limb strength in professional soccer players: profile, asymmetry, and training age.

PubMed

Fousekis, Konstantinos; Tsepis, Elias; Vagenas, George

2010-01-01

Kicking and cutting skills in soccer are clearly unilateral, require asymmetrical motor patterns and lead to the development of asymmetrical adaptations in the musculoskeletal function of the lower limbs. Assuming that these adaptations constitute a chronicity-dependent process, this study examined the effects of professional training age (PTA) on the composite strength profile of the knee and ankle joint in soccer players. One hundred soccer players (n=100) with short (5-7 years), intermediate (8-10 years) and long (>11 years) PTA were tested bilaterally for isokinetic concentric and eccentric strength of the knee and ankle muscles. Knee flexion-extension was tested concentrically at 60°, 180° and 300 °/sec and eccentrically at 60° and 180 °/sec. Ankle dorsal and plantar flexions were tested at 60 °/sec for both the concentric and eccentric mode of action. Bilaterally averaged muscle strength [(R+L)/2] increased significantly from short training age to intermediate and stabilized afterwards. These strength adaptations were mainly observed at the concentric function of knee extensors at 60°/sec (p = 0. 023), knee flexors at 60°/sec (p = 0.042) and 180°/sec (p = 0.036), and ankle plantar flexors at 60o/sec (p = 0.044). A linear trend of increase in isokinetic strength with PTA level was observed for the eccentric strength of knee flexors at 60°/sec (p = 0.02) and 180°/sec (p = 0.03). Directional (R/L) asymmetries decreased with PTA, with this being mainly expressed in the concentric function of knee flexors at 180°/sec (p = 0.04) and at 300 °/sec (p = 0.03). These findings confirm the hypothesis of asymmetry in the strength adaptations that take place at the knee and ankle joint of soccer players mainly along with short and intermediate PTA. Players with a longer PTA seem to adopt a more balanced use of their lower extremities to cope with previously developed musculoskeletal asymmetries and possibly reduce injury risk. This has certain implications regarding proper training and injury prevention in relation to professional experience in soccer. Key pointsMuscle strength increased from the low (5-7 years) to the intermediate professional training age (8-10 years) and stabilized thereafter.Soccer practicing and competition at the professional level induces critical strength adaptations (asymmetries) regarding the function of the knee and ankle musculature.Soccer players with long professional training age showed a tendency for lower isokinetic strength asymmetries than players with intermediate and short professional training age.

Usefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous Pemphigoid

PubMed Central

Lee, Eui Hyung; Kim, Yeon Hee; Kim, Sinyoung; Kim, Song-ee

2012-01-01

Background Bullous pemphigoid (BP) is an autoimmune subepidermal bullous disease associated with autoantibodies against BP180 and BP230. Enzyme-linked immunosorbent assay (ELISA) is a sensitive tool for the detection of immunoglobulin G (IgG) anti-BP180 and anti-BP230 autoantibodies. Objective The aim of this study was to evaluate the usefulness of ELISA for diagnosing and monitoring the disease activity of BP. Methods We evaluated serum IgG levels of anti-BP180 and anti-BP230 autoantibodies in 47 BP patients, 16 epidermolysis bullosa aquisita patients, and 15 healthy volunteers using ELISA. Through retrospective review of the medical records, the clinical characteristics of BP including disease activity, duration, pruritus severity and peripheral blood eosinophil counts were assessed. Results The sensitivity of BP180 ELISA was 97.9%, BP230 ELISA 72.3%, and a combination of the two was 100%. The specificity of BP180 ELISA was 90.3%, BP230 ELISA 100%, and a combination of the two was 90.3%. BP180 ELISA scores showed strong associations with disease activity, pruritus severity, peripheral blood eosinophil counts, and disease duration, whereas BP230 ELISA scores did not. Conclusion BP180 and BP230 ELISAs are highly sensitive methods for the diagnosis of BP, and BP180 ELISA, in particular, is a sensitive tool for monitoring the disease activity of BP. PMID:22363155

Studies of lead tungstate crystals for the ALICE electromagnetic calorimeter PHOS

NASA Astrophysics Data System (ADS)

Ippolitov, M.; Beloglovsky, S.; Bogolubsky, M.; Burachas, S.; Erin, S.; Klovning, A.; Kuriakin, A.; Lebedev, V.; Lobanov, M.; Maeland, O.; Manko, V.; Nikulin, S.; Nyanin, A.; Odland, O. H.; Punin, V.; Sadovsky, S.; Samoilenko, V.; Sibiriak, Yu.; Skaali, B.; Tsvetkov, A.; Vinogradov, Yu.; Vasiliev, A.

2002-06-01

Full-size (22×22×180 mm 3) A LICE crystals were delivered by "North Crystals" company, Apatity, Russia. These crystals were tested with test benches, specially built for measurements of the crystals optical transmission and light yield. Beam-test results of different sets of 3×3 matrices with Hamamatsu APD light readout are presented. Data were taken at electron momenta from 600 MeV/ c up to 10 GeV/ c. Energy resolution and linearity curves are measured. The tests were carried out at the C ERN PS and SPS secondary beam-lines.

2 CFR 1125.220 - What contracts and subcontracts, in addition to those listed in 2 CFR 180.220, are covered...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What contracts and subcontracts, in addition to those listed in 2 CFR 180.220, are covered transactions? 1125.220 Section 1125.220 Grants and... those listed in 2 CFR 180.220, are covered transactions? Although the OMB guidance at 2 CFR 180.220(c...

2 CFR 1400.220 - What contracts and subcontracts, in addition to those listed in 2 CFR 180.220, are covered...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false What contracts and subcontracts, in addition to those listed in 2 CFR 180.220, are covered transactions? 1400.220 Section 1400.220 Grants and... those listed in 2 CFR 180.220, are covered transactions? Although the OMB guidance at 2 CFR 180.220(c...

2 CFR 180.310 - What must I do if a Federal agency excludes a person with whom I am already doing business in a...

Code of Federal Regulations, 2010 CFR

2010-01-01

... is proper and appropriate. (b) You may not renew or extend covered transactions (other than no-cost... a person with whom I am already doing business in a covered transaction? 180.310 Section 180.310...) Responsibilities of Participants Regarding Transactions Doing Business With Other Persons § 180.310 What must I do...

Optimizing Nonlinear Beam Coupling in Low-Symmetry Crystals (Postprint)

DTIC Science & Technology

2014-10-02

Phys. Rev. E 55(1), 1035–1047 (1997). 9. Y. M. Vysochanskii and V. Y. Slivka, “ Ferroelectrics of the Sn2P2S6 family. Properties in Vicinity of Lifshitz...Standard on Piezoelectricity (IEEE, 1987), p. 242. 22. C. D. Carpentier and R. Nitsche, “ Ferroelectricity in Sn2P2S6,” Mater. Res. Bull. 9(8), 1097–1100...90 180 Θ , d e g -0.7 0.7 -180 -90 0 90 180 Θ , d e g -180 -90 0 90 180 j,deg -1. 1. Fig. 3. Pseudocolor 2D maps that represent normalized two-beam

Non-LTE radiating acoustic shocks and Ca II K2V bright points

NASA Technical Reports Server (NTRS)

Carlsson, Mats; Stein, Robert F.

1992-01-01

We present, for the first time, a self-consistent solution of the time-dependent 1D equations of non-LTE radiation hydrodynamics in solar chromospheric conditions. The vertical propagation of sinusoidal acoustic waves with periods of 30, 180, and 300 s is calculated. We find that departures from LTE and ionization recombination determine the temperature profiles of the shocks that develop. In LTE almost all the thermal energy goes into ionization, so the temperature rise is very small. In non-LTE, the finite transition rates delay the ionization to behind the shock front. The compression thus goes into thermal energy at the shock front leading to a high temperature amplitude. Further behind the shock front, the delayed ionization removes energy from the thermal pool, which reduces the temperature, producing a temperature spike. The 180 s waves reproduce the observed temporal changes in the calcium K line profiles quite well. The observed wing brightening pattern, the violet/red peak asymmetry and the observed line center behavior are all well reproduced. The short-period waves and the 5 minute period waves fail especially in reproducing the observed behavior of the wings.

PNP PIN bipolar phototransistors for high-speed applications built in a 180 nm CMOS process.

PubMed

Kostov, P; Gaberl, W; Hofbauer, M; Zimmermann, H

2012-08-01

This work reports on three speed optimized pnp bipolar phototransistors build in a standard 180 nm CMOS process using a special starting wafer. The starting wafer consists of a low doped p epitaxial layer on top of the p substrate. This low doped p epitaxial layer leads to a thick space-charge region between base and collector and thus to a high -3 dB bandwidth at low collector-emitter voltages. For a further increase of the bandwidth the presented phototransistors were designed with small emitter areas resulting in a small base-emitter capacitance. The three presented phototransistors were implemented in sizes of 40 × 40 μm 2 and 100 × 100 μm 2 . Optical DC and AC measurements at 410 nm, 675 nm and 850 nm were done for phototransistor characterization. Due to the speed optimized design and the layer structure of the phototransistors, bandwidths up to 76.9 MHz and dynamic responsivities up to 2.89 A/W were achieved. Furthermore simulations of the electric field strength and space-charge regions were done.

ACUTE FLACCID PARALYSIS SURVEILLANCE: A 5 YEARS STUDY OF BANNU, PAKISTAN.

PubMed

Faheem, Muhammad Umer; Haroon, Muhammad Zeeshan; Khan, Aftab Alam; Shaukat, Maryum; Anwar, Sved Abbas

2015-01-01

Acute flaccid paralysis (AFP) is clinical presentation marked by acute onset of weakness and reduced tone. Aetiologies of AFP are diverse including infectious agents, trauma or autoimmune reaction. Currently only three countries in the world that are Nigeria, Pakistan and Afghanistan have endemic poliomyelitis. Pakistan's polio crisis represents one of the last hurdles in a 23-year campaign run by the World Health Organization. Bannu due to its geographical location stands out to be one of highest risk areas for Poliomyelitis. The objective of this study was to determine frequency of AFP and their aetiologies in District of Bannu during time period of four years from 2007 to 2011. It was a cross-sectional descriptive study. Data was collected from EDO office District Bannu and analysed using Microsoft Excel 2007. Results: During this period there were 180 cases of AFP in district Bannu. 15% of cases were diagnosed as Guillian Barre Syndrome, making it the leading aetiology. Only 3 (1.66%) cases were diagnosed with Poliomyelitis. Out of 180 AFP cases 104 cases were male and 76 cases were female. Bannu needs enthusiastic educational and vaccination campaigns to eradicate Polio from the area and henceforth from the Pakistan.

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: Feasible or not?

PubMed Central

Tascilar, Oge; Cakmak, Güldeniz Karadeniz; Tekin, Ishak Ozel; Emre, Ali Ugur; Ucan, Bulent Hamdi; Irkorucu, Oktay; Karakaya, Kemal; Gül, Mesut; Engin, Hüseyin Bülent; Comert, Mustafa

2007-01-01

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up. CONCLUSION: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence. PMID:17907291

Magnetically Controlled Upper Ionosphere of Mars

NASA Astrophysics Data System (ADS)

Majeed, T.; Al Aryani, O.; Al Mutawa, S.; Bougher, S. W.; Haider, S. A.

2017-12-01

The electron density (Ne) profiles measured by the Mars Express spacecraft over regions of strong crustal magnetic fields have shown anomalous characteristics of the topside plasma distribution with variable scale heights. One of such Ne profiles is located at 82oS and 180oE whose topside ionosphere is extended up to an altitude of 700 km. The crustal magnetic field at this southern site is nearly vertical and open to the access of solar wind plasma through magnetic reconnection with the interplanetary magnetic field. This can lead to the acceleration of electrons and ions during the daytime ionosphere. The downward accelerated electrons with energies >200 eV can penetrate deep into the Martian upper ionosphere along vertical magnetic field lines and cause heating, excitation and ionization of the background atmosphere. The upward acceleration of ions resulting from energy input by precipitating electrons can lead to enhance ion escape rate and modify scale heights of the topside ionosphere. We have developed a 1-D chemical diffusive model from 100 km to 400 km to interpret the Martian ionospheric structure at 82oS latitude. The primary source of ionization in the model is due to solar EUV radiation. An extra ionization source due to precipitating electrons of 0.25 keV, peaking near an altitude of 145 km is added in the model to reasonably reproduce the measured ionospheric structure below an altitude of 180 km. The behavior of the topside ionosphere can be interpreted by the vertical plasma transport caused by precipitating electrons. The vertical transport of plasma in our model is simulated by vertical ion velocities, whose values can be interpreted as drift velocities along magnetic field lines. We find that the variation of the topside Ne scale heights is sensitive to the magnitudes of upward and downward drifts with an imposed outward flux boundary condition at the top of the model. The model requires an upward flux of more than 107 ions cm-2 s-1 for both O2+ and O+, and drift speeds of 200 m/s to interpret the measured topside ionospheric structure for altitudes >180 km. The magnitudes of outward ion fluxes and drift velocities are compared with those simulated by existing models. The model results will be presented in comparison with the measured electron density profile. This work is supported by MBRSC, Dubai, UAE.

Dietary lead: effects on hepatic fatty acid composition in chicks.

PubMed

Donaldson, W E; Leeming, T K

1984-03-30

Arbor Acre broiler chicks were fed diets containing 0, 500, 750, 1000, 2000, or 4000 ppm lead (as Pb acetate X 3 H2O) from day-old through 21 days of age. There were 8 groups of 10 male chicks per lead level. Eight chicks from each dietary lead level were killed at 21 days, and hepatic fatty acid composition was determined for each chick by gas-liquid chromatography. Increasing dietary lead levels decreased the concentrations of 16:1 and 18:1 fatty acids (first No. = No. carbons; second No. = No. double bonds) and increased the concentrations of 18:0 and 20:4. The concentration of 18:2 fatty acids did not differ significantly from control values for any level of lead. However, the ratio 18:2/20:4 declined from a control value of 3.3 to approximately 2 for all lead treatments. The ratio of saturated/monoenoic fatty acids increased with dietary lead levels above 1000 ppm. In a second experiment 10 male broiler chicks per treatment were fed either a control diet or the control diet plus 2000 ppm lead, 60 ppm cadmium, 500 ppm mercury, or 10 ppm selenium (as Pb acetate X 3 H2O, CdSO4, HgCl2, or Na2SeO3, respectively) for 21 days. Six chicks from each group were killed at 21 days, and hepatic fatty acid composition was determined for each chick. In comparison to control, the ratio 18:2/20:4 was lowered by lead but unaffected by cadmium, mercury, and selenium. The data suggest that lead may increase tissue peroxidation (as noted by other workers) via a relative increase of 20:4 fatty acid and that a decrease of hepatic ratio 18:2/20:4 may be a specific sign of lead toxicity.

Potential of dosage reduction in cone-beam-computed tomography (CBCT) for radiological diagnostics of the paranasal sinuses.

PubMed

Güldner, C; Ningo, A; Voigt, J; Diogo, I; Heinrichs, J; Weber, R; Wilhelm, T; Fiebich, M

2013-03-01

More than 10 years ago, cone-beam-computed tomography (CBCT) was introduced in ENT radiology. Until now, the focus of research was to evaluate clinical limits of this technique. The aim of this work is the evaluation of specific dosages and the identification of potential optimization in the performance of CBCT of the paranasal sinuses. Based on different tube parameters (tube current, tube voltage, and rotation angles), images of the nose and the paranasal sinuses were taken on a phantom head with the Accu-I-tomo F17 (Morita, Kyoto, Japan). The dosages applied to the lens and parotid gland were measured with OSL dosimetry. The imaging quality was evaluated by independent observers. All datasets were reviewed according to a checklist of surgically important anatomic structures. Even for lowest radiation exposure (4 mA, 76 kV, 180°, computed tomography dosage index (CTDI) = 1.8 mGy), the imaging quality was sufficient. Of course a significant reduction of the imaging quality could be seen, so a reliable mean was set for 4 mA, 84 kV, and 180° rotation angle (CTDI = 2.4 mGy). In this combination, a reduction of 92 % in lens-dose and of 77 % of dosage at the parotid gland was observed in comparison to the maximal possible adjustments (8 mA, 90 kV, 360°, CTDI = 10.9 mGy). There is potential for optimization in CBCT. Changing the rotation angle (180° instead of 360°) leads to a dose reduction of 50 %. Furthermore from clinical point of view in case of chronic rhinosinusitis a relevant reduction of dosage is possible. Therefore, it is necessary to intensify the interdisciplinary discussion about the disease specifics required quality of imaging.

Expression of lactate/H⁺ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses.

PubMed

Kim, Younghye; Choi, Jung-Woo; Lee, Ju-Han; Kim, Young-Sik

2015-01-01

Clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel-Lindau protein, leading to the accumulation of hypoxia-inducible factor-α (HIF-α). HIF-1α induces aerobic glycolysis, the Warburg effect, whereas HIF-2α functions as an oncoprotein. Lactate transport through monocarboxylate transporters (MCTs) and the chaperone CD147 is essential for high glycolytic cancer cell survival. To elucidate the clinical significance of MCT1, MCT4, and CD147 expression, we investigated their expressions by immunohistochemistry in ccRCC specimens and validated the results by an open-access The Cancer Genome Atlas data analysis. Overexpression of MCT1, MCT4, and CD147 was observed in 49.4% (89/180), 39.4% (71/180), and 79.4% (143/180) of ccRCC patients, respectively. High MCT1 expression was associated with older age (P = .017), larger tumor size (P = .015), and advanced TNM stage (P = .012). However, MCT4 overexpression was not related to any variables. CD147 overexpression correlated with high grade (P = .005), tumor necrosis (P = .016), and larger tumor size (P = .038). In univariate analysis, high expression of MCT1 (P < .001), MCT4 (P = .016), and CD147 (P = .02) was linked to short progression-free survival. In multivariate analysis, high MCT1 expression was associated with worse progression-free survival (P = .001). In conclusion, high expression of MCT1 and CD147 is associated with poor prognostic factors. Overexpression of MCT1, MCT4, and CD147 predicts tumor progression. Reversing the Warburg effect by targeting the lactate transporters may be a useful strategy to prevent ccRCC progression. Copyright © 2014 Elsevier Inc. All rights reserved.

Efficient and rapid degradation of Congo red dye with TiO2 based nano-photocatalysts

NASA Astrophysics Data System (ADS)

Narayan, Himanshu; Alemu, Hailemichael

2017-04-01

Degradation of Congo red (CR) dye with TiO2 based nano-photocatalyst (NPC) loaded with Nd3+ and Er3+ ions is reported. The chemical route of synthesis through co-precipitation/hydrolysis (CPH) was employed to produce NPCs with general composition TiO2[R2O3]x, {x = 0.1, 0.2; R □ Nd, Er} and particle size within 12 - 16 nm. Photocatalytic degradation under visible light was measured in terms of the percent degradation of CR in 180 min ({C}180\\prime), time taken to degrade to half of the initial CR concentration (t1/2) and apparent rate constant (kobs). For both doping types, values of {C}180\\prime close to 100% were obtained with x = 0.2 NPCs, indicating complete removal of the dye. For the same NPCs, very high values of kobs were found; 2.91 × 10-2 min-1 and 2.36 × 10-2 min-1, for Nd3+ and Er3+ loaded NPCs, respectively, suggesting very rapid degradation. Other NPCs with x = 0.1, also showed reasonably good and fast degradation of CR. The observations may be attributed to the small particle size of the NPCs. Moreover, from the DRS results it is observed that the addition of Nd3+ and Er3+ ions apparently introduces intermediate energy levels within the band gap of TiO2. Such new levels seem to support photocatalysis because they act as electron traps leading to effective suppression of the undesired e-/h+ recombination. To some meaningful extent they also facilitate the absorption of visible irradiations required in the process.

Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe?

PubMed

Cotter, Gad; Metra, Marco; Davison, Beth A; Jondeau, Guillaume; Cleland, John G F; Bourge, Robert C; Milo, Olga; O'Connor, Christopher M; Parker, John D; Torre-Amione, Guillermo; van Veldhuisen, Dirk J; Kobrin, Isaac; Rainisio, Maurizio; Senger, Stefanie; Edwards, Christopher; McMurray, John J V; Teerlink, John R

2018-02-01

Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes. We analysed associations of SBP decrease during the first 24 h from randomization with serum creatinine changes at the last time-point available (72 h), using linear regression, and with 30- and 180-day outcomes, using Cox regression, in 1257 patients in the VERITAS study. After multivariable adjustment for baseline SBP, greater SBP decrease at 24 h from randomization was associated with greater creatinine increase at 72 h and greater risk for 30-day all-cause death, worsening heart failure (HF) or HF readmission. The hazard ratio (HR) for each 1 mmHg decrease in SBP at 24 h for 30-day death, worsening HF or HF rehospitalization was 1.01 [95% confidence interval (CI) 1.00-1.02; P = 0.021]. Similarly, the HR for each 1 mmHg decrease in SBP at 24 h for 180-day all-cause mortality was 1.01 (95% CI 1.00-1.03; P = 0.038). The associations between SBP decrease and outcomes did not differ by tezosentan treatment group, although tezosentan treatment was associated with a greater SBP decrease at 24 h. In the current post hoc analysis, SBP decrease during the first 24 h was associated with increased renal impairment and adverse outcomes at 30 and 180 days. Caution, with special attention to blood pressure monitoring, should be exercised when vasodilating agents are given to AHF patients. © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.

Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes.

PubMed

Ferrante, Maria C; Amero, Paola; Santoro, Anna; Monnolo, Anna; Simeoli, Raffaele; Di Guida, Francesca; Mattace Raso, Giuseppina; Meli, Rosaria

2014-09-15

Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) are highly lipophilic environmental contaminants that accumulate in lipid-rich tissues, such as adipose tissue. Here, we reported the effects induced by PCBs 101, 153 and 180, three of the six NDL-PCBs defined as indicators, on mature 3T3-L1 adipocytes. We observed an increase in lipid content, in leptin gene expression and a reduction of leptin receptor expression and signaling, when cells were exposed to PCBs, alone or in combination. These modifications were consistent with the occurrence of "leptin-resistance" in adipose tissue, a typical metabolic alteration related to obesity. Therefore, we investigated how PCBs affect the expression of pivotal proteins involved in the signaling of leptin receptor. We evaluated the PCB effect on the intracellular pathway JAK/STAT, determining the phosphorylation of STAT3, a downstream activator of the transcription of leptin gene targets, and the expression of SOCS3 and PTP1B, two important regulators of leptin resistance. In particular, PCBs 153 and 180 or all PCB combinations induced a significant reduction in pSTAT3/STAT3 ratio and an increase in PTP1B and SOCS3, evidencing an additive effect. The impairment of leptin signaling was associated with the reduction of AMPK/ACC pathway activation, leading to the increase in lipid content. These pollutants were also able to increase the transcription of inflammatory cytokines (IL-6 and TNFα). It is worthy to note that the PCB concentrations used are comparable to levels detectable in human adipose tissue. Our data strongly support the hypothesis that NDL-PCBs may interfere with the lipid metabolism contributing to the development of obesity and related diseases. Copyright © 2014 Elsevier Inc. All rights reserved.

Clients' outcomes of home health nursing in Taiwan.

PubMed

Yeh, L; Wen, M J

2001-09-01

The home health nursing movement is expanding rapidly. Home health nursing agencies (HHNAs) are expected to demonstrate that the care provided does make a difference for the client receiving the services. The purpose of this study was to explore client outcomes from home health nursing. Outcome indicators include: Services utilized (emergency services, re-hospitalization), physiological status (catheter indwelling status, consciousness level, wound severity-number and wound stages) and functional status (reflected by Barthel Index). A prospective research design was used to collect the results. Five hospital-based HHNAs were invited to participate in this research. Clients newly admitted to HHNAs and diagnosed as non-cancer patients were recruited, and the researchers gathered outcome indicators over a six-month period. Data were analyzed using SPSS 8.0 computer software. There were 75 clients in this study. Results showed that most of the clients (64.0%) received service for more than 180 days. The client characteristics were dominated by elderly (66.6% age above 70), female (53.3%) and married (74.7%). The three leading care needs were NG tubing service (84.0%), Foley tubing service (45.3%) and wound care (38.7%). The Kruscal Wallis Test revealed that there was no difference in emergency service frequency and re-hospitalization between clients who received service for more than 180 days and those who received service for less than 180 days. The Wilcoxon Sign rank test showed that within one half-year, catheter indwelling status, functional status, and wound severity were not significantly different, with the exception only of conscious level (p = .001). The results of this study can be viewed as preliminary data to assist in shaping home health nursing services in Taiwan.

43 CFR 30.180 - May I give up an inherited interest in trust or restricted property or trust personalty?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false May I give up an inherited interest in trust or restricted property or trust personalty? 30.180 Section 30.180 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE HEARINGS PROCEDURES Renunciation of Interest § 30.180 May I give up an inherited interest in trust or...

2 CFR 180.350 - What must I do if I learn of information required under § 180.335 after entering into a covered...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What must I do if I learn of information...-Primary Tier Participants § 180.350 What must I do if I learn of information required under § 180.335... entered into the transaction if you learn either that— (a) You failed to disclose information earlier, as...

49 CFR Appendix C to Part 180 - Eddy Current Examination With Visual Inspection for DOT 3AL Cylinders Manufactured of Aluminum...

Code of Federal Regulations, 2013 CFR

2013-10-01

... for DOT 3AL Cylinders Manufactured of Aluminum Alloy 6351-T6 C Appendix C to Part 180 Transportation... Pt. 180, App. C Appendix C to Part 180—Eddy Current Examination With Visual Inspection for DOT 3AL... with CGA pamphlet C-6.1 (IBR; see § 171.7 of this subchapter). 3. Eddy Current Equipment. A reference...

The effect of lead exposure on fatty acid composition in mouse brain analyzed using pseudo-catalytic derivatization.

PubMed

Jung, Jong-Min; Lee, Jechan; Kim, Ki-Hyun; Jang, In Geon; Song, Jae Gwang; Kang, Kyeongjin; Tack, Filip M G; Oh, Jeong-Ik; Kwon, Eilhann E; Kim, Hyung-Wook

2017-03-01

We performed toxicological study of mice exposed to lead by quantifying fatty acids in brain of the mice. This study suggests that the introduced analytical method had an extremely high tolerance against impurities such as water and extractives; thus, it led to the enhanced resolution in visualizing the spectrum of fatty acid profiles in animal brain. Furthermore, one of the biggest technical advantages achieved in this study was the quantitation of fatty acid methyl ester profiles of mouse brain using a trace amount of sample (e.g., 100 μL mixture). Methanol was screened as the most effective extraction solvent for mouse brain. The behavioral test of the mice before and after lead exposure was conducted to see the effect of lead exposure on fatty acid composition of the mice' brain. The lead exposure led to changes in disease-related behavior of the mice. Also, the lead exposure induced significant alterations of fatty acid profile (C16:0, C 18:0, and C 18:1) in brain of the mice, implicated in pathology of psychiatric diseases. The alteration of fatty acid profile of brain of the mice suggests that the derivatizing technique can be applicable to most research fields associated with the environmental neurotoxins with better resolution in a short time, as compared to the current protocols for lipid analysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Improvement of fatigue resistance for multilayer lead zirconate titanate (PZT)-based ceramic actuators by external mechanical loads

NASA Astrophysics Data System (ADS)

Yang, Gang; Yue, Zhenxing; Ji, Ye; Chu, Xiangcheng; Li, Longtu

2008-12-01

The influence of external compressive loads, applied along a direction perpendicular to polarization, on fatigue behaviors of multilayer lead zirconate titanate (PZT)-based ceramic actuators was investigated. Under no external mechanical load, a normal fatigue behavior was observed, demonstrating that both switching polarization (Pswitching) and remnant polarization (Pr) progressively decreased with increasing switching cycles due to domain pinning by charge point defects. However, an anomalous enhancement in both switching and remnant polarizations was observed upon application of the external compressive loads. After 5×106 cycles of polarization switching, Pswitching and Pr increase by about 13% and 6% at 40 MPa, respectively, while Pswitching and Pr increase by about 11% and 21% at 60 MPa, respectively. The improvement of fatigue resistance can be attributed to non-180° domain switching and suppression of microcracking, triggered by external mechanical loads.

40 CFR 161.180 - Enforcement analytical method.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Enforcement analytical method. 161.180 Section 161.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements...

40 CFR 161.180 - Enforcement analytical method.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Enforcement analytical method. 161.180 Section 161.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements...

40 CFR 161.180 - Enforcement analytical method.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Enforcement analytical method. 161.180 Section 161.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements...

Conference Proceedings of Energy Absorption of Aircraft Structures as an Aspect Crashworthiness (66th) Held in Luxembourg on 1-6 May 1988

DTIC Science & Technology

1988-12-01

efforts dans les f~murs ou dans la colonne vert~brale. 2.1.3. Jauges 11 peut s’agir de jauges simples, doubles ou de rosettes 3 directions. Les jauges ...34, -acc~l~rombtres mannequin en "classe 180", -efforts en "classe 180", - jauges en "classe 180", -r~sultantes efforts en "classe 180", -sommes des

Description of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with Severe Lead Poisoning in Zamfara, Northern Nigeria: A Retrospective Analysis of Programme Data

PubMed Central

Thurtle, Natalie; Greig, Jane; Cooney, Lauren; Amitai, Yona; Ariti, Cono; Brown, Mary Jean; Kosnett, Michael J.; Moussally, Krystel; Sani-Gwarzo, Nasir; Akpan, Henry; Shanks, Leslie; Dargan, Paul I.

2014-01-01

Background In 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo. The US Centers for Disease Control and Prevention (CDC) confirmed widespread contamination from lead-rich ore being processed for gold, and environmental management was begun. MSF commenced a medical management programme that included treatment with the oral chelating agent 2,3-dimercaptosuccinic acid (DMSA, succimer). Here we describe and evaluate the changes in venous blood lead level (VBLL) associated with DMSA treatment in the largest cohort of children ≤5 y of age with severe paediatric lead intoxication reported to date to our knowledge. Methods and Findings In a retrospective analysis of programme data, we describe change in VBLL after DMSA treatment courses in a cohort of 1,156 children ≤5 y of age who underwent between one and 15 courses of chelation treatment. Courses of DMSA of 19 or 28 d duration administered to children with VBLL ≥ 45 µg/dl were included. Impact of DMSA was calculated as end-course VBLL as a percentage of pre-course VBLL (ECP). Mixed model regression with nested random effects was used to evaluate the relative associations of covariates with ECP. Of 3,180 treatment courses administered, 36% and 6% of courses commenced with VBLL ≥ 80 µg/dl and ≥ 120 µg/dl, respectively. Overall mean ECP was 74.5% (95% CI 69.7%–79.7%); among 159 inpatient courses, ECP was 47.7% (95% CI 39.7%–57.3%). ECP after 19-d courses (n = 2,262) was lower in older children, first-ever courses, courses with a longer interval since a previous course, courses with more directly observed doses, and courses with higher pre-course VBLLs. Low haemoglobin was associated with higher ECP. Twenty children aged ≤5 y who commenced chelation died during the period studied, with lead poisoning a primary factor in six deaths. Monitoring of alanine transaminase (ALT), creatinine, and full blood count revealed moderate ALT elevation in <2.5% of courses. No clinically severe adverse drug effects were observed, and no laboratory findings required discontinuation of treatment. Limitations include that this was a retrospective analysis of clinical data, and unmeasured variables related to environmental exposures could not be accounted for. Conclusions Oral DMSA was a pharmacodynamically effective chelating agent for the treatment of severe childhood lead poisoning in a resource-limited setting. Re-exposure to lead, despite efforts to remediate the environment, and non-adherence may have influenced the impact of outpatient treatment. Please see later in the article for the Editors' Summary PMID:25291378

2 CFR 180.900 - Adequate evidence.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Adequate evidence. 180.900 Section 180.900 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS... belief that a particular act or omission has occurred. ...

Stress Testing of an Artificial Pancreas System With Pizza and Exercise Leads to Improvements in the System's Fuzzy Logic Controller.

PubMed

Mauseth, Richard; Lord, Sandra M; Hirsch, Irl B; Kircher, Robert C; Matheson, Don P; Greenbaum, Carla J

2015-09-14

Under controlled conditions, the Dose Safety artificial pancreas (AP) system controller, which utilizes "fuzzy logic" (FL) methodology to calculate and deliver appropriate insulin dosages based on changes in blood glucose, successfully managed glycemic excursions. The aim of this study was to show whether stressing the system with pizza (high carbohydrate/high fat) meals and exercise would reveal deficits in the performance of the Dose Safety FL controller (FLC) and lead to improvements in the dosing matrix. Ten subjects with type 1 diabetes (T1D) were enrolled and participated in 30 studies (17 meal, 13 exercise) using 2 versions of the FLC. After conducting 13 studies with the first version (FLC v2.0), interim results were evaluated and the FLC insulin-dosing matrix was modified to create a new controller version (FLC v2.1) that was validated through regression testing using v2.0 CGM datasets prior to its use in clinical studies. The subsequent 17 studies were performed using FLC v2.1. Use of FLC v2.1 vs FLC v2.0 in the pizza meal tests showed improvements in mean blood glucose (205 mg/dL vs 232 mg/dL, P = .04). FLC v2.1 versus FLC v2.0 in exercise tests showed improvements in mean blood glucose (146 mg/dL vs 201 mg/dL, P = .004), percentage time spent >180 mg/dL (19.3% vs 46.7%, P = .001), and percentage time spent 70-180 mg/dL (80.0% vs 53.3%, P = .002). Stress testing the AP system revealed deficits in the FLC performance, which led to adjustments to the dosing matrix followed by improved FLC performance when retested. © 2015 Diabetes Technology Society.

Design consideration of a multipinhole collimator with septa for ultra high-resolution silicon drift detector modules

NASA Astrophysics Data System (ADS)

Min, Byung Jun; Choi, Yong; Lee, Nam-Yong; Lee, Kisung; Ahn, Young Bok; Joung, Jinhun

2009-07-01

The aim of this study was to design a multipinhole (MP) collimator with lead vertical septa coupled to a high-resolution detector module containing silicon drift detectors (SDDs) with an intrinsic resolution approaching the sub-millimeter level. Monte Carlo simulations were performed to determine pinhole parameters such as pinhole diameter, focal length, and number of pinholes. Effects of parallax error and collimator penetration were investigated for the new MP collimator design. The MP detector module was evaluated using reconstructed images of resolution and mathematical cardiac torso (MCAT) phantoms. In addition, the reduced angular sampling effect was investigated over 180°. The images were reconstructed using dedicated maximum likelihood expectation maximization (MLEM) algorithm. An MP collimator with 81-pinhole was designed with a 2-mm-diameter pinhole and a focal length of 40 mm . Planar sensitivity and resolution obtained using the devised MP collimator were 3.9 cps/μCi and 6 mm full-width at half-maximum (FWHM) at a 10 cm distance. The parallax error and penetration ratio were significantly improved using the proposed MP collimation design. The simulation results demonstrated that the proposed MP detector provided enlarged imaging field of view (FOV) and improved the angular sampling effect in resolution and MCAT phantom studies. Moreover, the novel design enables tomography images by simultaneously obtaining eight projections with eight-detector modules located along the 180° orbit surrounding a patient, which allows designing of a stationary cardiac SPECT. In conclusion, the MP collimator with lead vertical septa was designed to have comparable system resolution and sensitivity to those of the low-energy high-resolution (LEHR) collimator per detector. The system sensitivity with an eight-detector configuration would be four times higher than that with a standard dual-detector cardiac SPECT.

Unique Proton Transportation Pathway in a Robust Inorganic Coordination Polymer Leading to Intrinsically High and Sustainable Anhydrous Proton Conductivity.

PubMed

Gui, Daxiang; Dai, Xing; Tao, Zetian; Zheng, Tao; Wang, Xiangxiang; Silver, Mark A; Shu, Jie; Chen, Lanhua; Wang, Yanlong; Zhang, Tiantian; Xie, Jian; Zou, Lin; Xia, Yuanhua; Zhang, Jujia; Zhang, Jin; Zhao, Ling; Diwu, Juan; Zhou, Ruhong; Chai, Zhifang; Wang, Shuao

2018-05-16

Although comprehensive progress has been made in the area of coordination polymer (CP)/metal-organic framework (MOF)-based proton-conducting materials over the past decade, searching for a CP/MOF with stable, intrinsic, high anhydrous proton conductivity that can be directly used as a practical electrolyte in an intermediate-temperature proton-exchange membrane fuel cell assembly for durable power generation remains a substantial challenge. Here, we introduce a new proton-conducting CP, (NH 4 ) 3 [Zr(H 2/3 PO 4 ) 3 ] (ZrP), which consists of one-dimensional zirconium phosphate anionic chains and fully ordered charge-balancing NH 4 + cations. X-ray crystallography, neutron powder diffraction, and variable-temperature solid-state NMR spectroscopy suggest that protons are disordered within an inherent hydrogen-bonded infinite chain of acid-base pairs (N-H···O-P), leading to a stable anhydrous proton conductivity of 1.45 × 10 -3 S·cm -1 at 180 °C, one of the highest values among reported intermediate-temperature proton-conducting materials. First-principles and quantum molecular dynamics simulations were used to directly visualize the unique proton transport pathway involving very efficient proton exchange between NH 4 + and phosphate pairs, which is distinct from the common guest encapsulation/dehydration/superprotonic transition mechanisms. ZrP as the electrolyte was further assembled into a H 2 /O 2 fuel cell, which showed a record-high electrical power density of 12 mW·cm -2 at 180 °C among reported cells assembled from crystalline solid electrolytes, as well as a direct methanol fuel cell for the first time to demonstrate real applications. These cells were tested for over 15 h without notable power loss.

Subepidermal Blistering Induced by Human Autoantibodies to BP180 Requires Innate Immune Players in a Humanized Bullous Pemphigoid Mouse Model

PubMed Central

Liu, Zhi; Sui, Wen; Zhao, Minglang; Li, Zhuowei; Li, Ning; Thresher, Randy; Giudice, George J.; Fairley, Janet A.; Sitaru, Cassian; Zillikens, Detlef; Ning, Gang; Marinkovich, Peter; Diaz, Luis A.

2008-01-01

Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and target multiple BP180 epitopes that are highly clustered within a non-collagen linker domain, termed NC16A. Anti-BP180 antibodies induce BP in mice. In this study, we generated a humanized mouse strain, in which the murine BP180NC14A is replaced with the homologous human BP180NC16A epitope cluster region. We show that the humanized NC16A (NC16A+/+) mice injected with anti-BP180NC16A autoantibodies develop BP-like subepidermal blisters. The F(ab′)2 fragments of pathogenic IgG fail to activate complement cascade and are no longer pathogenic. The NC16A+/+ mice pretreated with mast cell activation blocker or depleting of complement or neutrophils become resistant to BP. These findings suggest that the humoral response in BP critically depends on innate immune system players. PMID:18922680

2 CFR 176.180 - Procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Procedure. 176.180 Section 176.180 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved AWARD TERMS FOR ASSISTANCE AGREEMENTS THAT INCLUDE FUNDS UNDER THE AMERICAN RECOVERY AND...

40 CFR 161.180 - Enforcement analytical method.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Enforcement analytical method. 161.180... DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.180 Enforcement analytical method. An analytical method suitable for enforcement purposes must be...

40 CFR 180.1195 - Titanium dioxide.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Titanium dioxide. 180.1195 Section 180.1195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Titanium dioxide. Titanium dioxide is exempted from the requirement of a tolerance for residues in or on...

40 CFR 180.1195 - Titanium dioxide.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Titanium dioxide. 180.1195 Section 180.1195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Titanium dioxide. Titanium dioxide is exempted from the requirement of a tolerance for residues in or on...

40 CFR 180.1195 - Titanium dioxide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Titanium dioxide. 180.1195 Section 180.1195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... Titanium dioxide. Titanium dioxide is exempted from the requirement of a tolerance for residues in or on...

24 CFR 180.310 - Parties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Parties. 180.310 Section 180.310 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT EMPLOYMENT AND BUSINESS...

40 CFR 180.350 - Nitrapyrin; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Nitrapyrin; tolerances for residues. 180.350 Section 180.350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... residues of the soil microbiocide nitrapyrin [2-chloro-6-(trichloromethyl) pyridine] and its metabolite, 6...

The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

PubMed Central

Nielsen, Christoffer Fagernæs; van Putten, Sander Maarten; Lund, Ida Katrine; Melander, Maria Carlsén; Nørregaard, Kirstine Sandal; Jürgensen, Henrik Jessen; Reckzeh, Kristian; Christensen, Kristine Rothaus; Ingvarsen, Signe Ziir; Gårdsvoll, Henrik; Jensen, Kamilla Ellermann; Hamerlik, Petra; Engelholm, Lars Henning; Behrendt, Niels

2017-01-01

A key task in developing the field of personalized cancer therapy is the identification of novel molecular targets that enable treatment of cancers not susceptible to other means of specific therapy. The collagen receptor uPARAP/Endo180 is overexpressed by malignant cells in several non-epithelial cancers, notably including sarcomas, glioblastomas and subsets of acute myeloid leukemia. In contrast, in healthy adult individuals, expression is restricted to minor subsets of mesenchymal cells. Functionally, uPARAP/Endo180 is a rapidly recycling endocytic receptor that delivers its cargo directly into the endosomal-lysosomal system, thus opening a potential route of entry into receptor-positive cells. This combination of specific expression and endocytic function appears well suited for targeting of uPARAP/Endo180-positive cancers by antibody-drug conjugate (ADC) mediated drug delivery. Therefore, we utilized a specific monoclonal antibody against uPARAP/Endo180, raised through immunization of a uPARAP/Endo180 knock-out mouse, which reacts with both the human and the murine receptor, to construct a uPARAP-directed ADC. This antibody was coupled to the highly toxic dolastatin derivative, monomethyl auristatin E, via a cathepsin-labile valine-citrulline linker. With this ADC, we show strong and receptor-dependent cytotoxicity in vitro in uPARAP/Endo180-positive cancer cell lines of sarcoma, glioblastoma and leukemic origin. Furthermore, we demonstrate the potency of the ADC in vivo in a xenograft mouse model with human uPARAP/Endo180-positive leukemic cells, obtaining a complete cure of all tested mice following intravenous ADC treatment with no sign of adverse effects. Our study identifies uPARAP/Endo180 as a promising target for novel therapy against several highly malignant cancer types. PMID:28574834

40 CFR 180.200 - Dicloran; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

....200 Section 180.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.200..., postharvest 10 Celery 15 Cherry, sweet, postharvest 20 Cucumber 5 Endive 10 Garlic 5 Grape 10 Lettuce 10...

40 CFR 180.517 - Fipronil; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Fipronil; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.517 Fipronil; tolerances for residues. (a) General. Therefore, tolerances are established for combined residues...

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Safrole. 189.180 Section 189.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

2 CFR 180.965 - Legal proceedings.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Legal proceedings. 180.965 Section 180.965 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Legal proceedings. Legal proceedings means any criminal proceeding or any civil judicial proceeding...

2 CFR 180.965 - Legal proceedings.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Legal proceedings. 180.965 Section 180.965 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Legal proceedings. Legal proceedings means any criminal proceeding or any civil judicial proceeding...

2 CFR 176.180 - Procedure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Procedure. 176.180 Section 176.180 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS NATIONAL POLICY REQUIREMENTS AWARD TERMS...

46 CFR 180.150 - Survival craft embarkation arrangements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft embarkation arrangements. 180.150 Section... (UNDER 100 GROSS TONS) LIFESAVING EQUIPMENT AND ARRANGEMENTS Survival Craft Arrangements and Equipment § 180.150 Survival craft embarkation arrangements. (a) A launching appliance approved under approval...

49 CFR 180.513 - Repairs, alterations, conversions, and modifications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Repairs, alterations, conversions, and modifications. 180.513 Section 180.513 Transportation Other Regulations Relating to Transportation PIPELINE AND... Repairs, alterations, conversions, and modifications. (a) In order to repair tank cars, the tank car...

49 CFR 180.513 - Repairs, alterations, conversions, and modifications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Repairs, alterations, conversions, and modifications. 180.513 Section 180.513 Transportation Other Regulations Relating to Transportation (Continued..., alterations, conversions, and modifications. (a) In order to repair tank cars, the tank car facility must...

Estimates of genetic parameters, genetic trends, and inbreeding in a crossbred dairy sheep research flock in the United States.

PubMed

Murphy, T W; Berger, Y M; Holman, P W; Baldin, M; Burgett, R L; Thomas, D L

2017-10-01

For the past 2 decades, the Spooner Agriculture Research Station (ARS) of the University of Wisconsin-Madison operated the only dairy sheep research flock in North America. The objectives of the present study were to 1) obtain estimates of genetic parameters for lactation and reproductive traits in dairy ewes, 2) estimate the amount of genetic change in these traits over time, and 3) quantify the level of inbreeding in this flock over the last 20 yr. Multiple-trait repeatability models (MTRM) were used to analyze ewe traits through their first 6 parities. The first MTRM jointly analyzed milk (180-d-adjusted milk yield [180d MY]), fat (180-d-adjusted fat yield [180d FY]), and protein (180-d-adjusted protein yield [180d PY]) yields adjusted to 180 d of lactation; number of lambs born per ewe lambing (NLB); and lactation average test-day somatic cell score (LSCS). A second MTRM analyzed 180d MY, NLB, LSCS, and percentage milk fat (%F) and percentage milk protein (%P). The 3 yield traits were moderately heritable (0.26 to 0.32) and strongly genetically correlated (0.91 to 0.96). Percentage milk fat and %P were highly heritable (0.53 and 0.61, respectively) and moderately genetically correlated (0.61). Milk yield adjusted to 180 d was negatively genetically correlated with %F and %P (-0.31 and -0.34, respectively). Ewe prolificacy was not significantly ( > 0.67) genetically correlated with yield traits, %P, or LSCS but lowly negatively correlated with %F (-0.26). Lactation somatic cell score was unfavorably genetically correlated with yield traits (0.28 to 0.39) but not significantly ( > 0.09) correlated with %F, %P, and NLB. Within-trait multiple-trait models through the first 4 parities revealed that 180d MY, 180d FY, 180d PY, %F, and %P were strongly genetically correlated across parity (0.67 to 1.00). However, the genetic correlations across parity for NLB and LSCS were somewhat lower (0.51 to 0.96). Regressing predicted breeding values for 180d MY, without and with the addition of breed effects, on ewe year of birth revealed a positive genetic gain of 2.30 and 6.24 kg/yr, respectively, over the past 20 yr in this flock. Inbreeding coefficients of ewes with an extended pedigree ranged from 0.0 to 0.29, with an average of 0.07. To optimize genetic gains and avoid excessive inbreeding, the development of a national genetic improvement program should be a top priority for the growing dairy sheep industry.

Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: a single-arm, open-label, phase 1/2 trial.

PubMed

Gettinger, Scott N; Bazhenova, Lyudmila A; Langer, Corey J; Salgia, Ravi; Gold, Kathryn A; Rosell, Rafael; Shaw, Alice T; Weiss, Glen J; Tugnait, Meera; Narasimhan, Narayana I; Dorer, David J; Kerstein, David; Rivera, Victor M; Clackson, Timothy; Haluska, Frank G; Camidge, David Ross

2016-12-01

Anaplastic lymphoma kinase (ALK) gene rearrangements are oncogenic drivers of non-small-cell lung cancer (NSCLC). Brigatinib (AP26113) is an investigational ALK inhibitor with potent preclinical activity against ALK mutants resistant to crizotinib and other ALK inhibitors. We aimed to assess brigatinib in patients with advanced malignancies, particularly ALK-rearranged NSCLC. In this ongoing, single-arm, open-label, phase 1/2 trial, we recruited patients from nine academic hospitals or cancer centres in the USA and Spain. Eligible patients were at least 18 years of age and had advanced malignancies, including ALK-rearranged NSCLC, and disease that was refractory to available therapies or for which no curative treatments existed. In the initial dose-escalation phase 1 stage of the trial, patients received oral brigatinib at total daily doses of 30-300 mg (according to a standard 3 + 3 design). The phase 1 primary endpoint was establishment of the recommended phase 2 dose. In the phase 2 expansion stage, we assessed three oral once-daily regimens: 90 mg, 180 mg, and 180 mg with a 7 day lead-in at 90 mg; one patient received 90 mg twice daily. We enrolled patients in phase 2 into five cohorts: ALK inhibitor-naive ALK-rearranged NSCLC (cohort 1), crizotinib-treated ALK-rearranged NSCLC (cohort 2), EGFR T790M -positive NSCLC and resistance to one previous EGFR tyrosine kinase inhibitor (cohort 3), other cancers with abnormalities in brigatinib targets (cohort 4), and crizotinib-naive or crizotinib-treated ALK-rearranged NSCLC with active, measurable, intracranial CNS metastases (cohort 5). The phase 2 primary endpoint was the proportion of patients with an objective response. Safety and activity of brigatinib were analysed in all patients in both phases of the trial who had received at least one dose of treatment. This trial is registered with ClinicalTrials.gov, number NCT01449461. Between Sept 20, 2011, and July 8, 2014, we enrolled 137 patients (79 [58%] with ALK-rearranged NSCLC), all of whom were treated. Dose-limiting toxicities observed during dose escalation included grade 3 increased alanine aminotransferase (240 mg daily) and grade 4 dyspnoea (300 mg daily). We initially chose a dose of 180 mg once daily as the recommended phase 2 dose; however, we also assessed two additional regimens (90 mg once daily and 180 mg once daily with a 7 day lead-in at 90 mg) in the phase 2 stage. four (100% [95% CI 40-100]) of four patients in cohort 1 had an objective response, 31 (74% [58-86]) of 42 did in cohort 2, none (of one) did in cohort 3, three (17% [4-41]) of 18 did in cohort 4, and five (83% [36-100]) of six did in cohort 5. 51 (72% [60-82]) of 71 patients with ALK-rearranged NSCLC with previous crizotinib treatment had an objective response (44 [62% (50-73)] had a confirmed objective response). All eight crizotinib-naive patients with ALK-rearranged NSCLC had a confirmed objective response (100% [63-100]). Three (50% [95% CI 12-88]) of six patients in cohort 5 had an intracranial response. The most common grade 3-4 treatment-emergent adverse events across all doses were increased lipase concentration (12 [9%] of 137), dyspnoea (eight [6%]), and hypertension (seven [5%]). Serious treatment-emergent adverse events (excluding neoplasm progression) reported in at least 5% of all patients were dyspnoea (ten [7%]), pneumonia (nine [7%]), and hypoxia (seven [5%]). 16 (12%) patients died during treatment or within 31 days of the last dose of brigatinib, including eight patients who died from neoplasm progression. Brigatinib shows promising clinical activity and has an acceptable safety profile in patients with crizotinib-treated and crizotinib-naive ALK-rearranged NSCLC. These results support its further development as a potential new treatment option for patients with advanced ALK-rearranged NSCLC. A randomised phase 2 trial in patients with crizotinib-resistant ALK-rearranged NSCLC is prospectively assessing the safety and efficacy of two regimens assessed in the phase 2 portion of this trial (90 mg once daily and 180 mg once daily with a 7 day lead-in at 90 mg). ARIAD Pharmaceuticals. Copyright © 2016 Elsevier Ltd. All rights reserved.

Physiological Characteristics and Anti-obesity Effect of Lactobacillus plantarum Q180 Isolated from Feces

PubMed Central

Park, Sun-Young; Cho, Seong-A; Kim, Sae-Hun; Lim, Sang-Dong

2014-01-01

Obesity is strongly associated with several metabolic and chronic diseases and has become a major public health problem of worldwide concern. This study aimed to investigate the physiological characteristics and anti-obesity effects of Lactobacillus plantarum Q180. Lactobacillus plantarum Q180 was isolated from the faces of healthy adults and found to have a lipase inhibitory activity of 83.61±2.32% and inhibited adipocyte differentiation of 3T3-L1 cells (14.63±1.37%) at a concentration of 100 μg/mL. The strain was investigated for its physiological characteristics. The optimum growth temperature of L. plantarum Q180 was 37℃. Lactobacillus plantarum Q180 showed higher sensitivity to novobiocin in a comparison of fifteen different antibiotics and showed the highest resistance to rifampicin, polymyxin B and vancomycin. The strain showed higher β-galactosidase and N-acetyl-β-glucosaminidase activities. It also did not produce carcinogenic enzymes such as β-glucuronidase. The survival rate of L. plantarum Q180 in MRS broth containing 0.3% bile was 97.8%. Moreover, the strain showed a 97.2% survival rate after incubation for 3 h in pH 2.0. Lactobacillus plantarum Q180 was displayed resistance to Escherichia coli, Salmonella Typhimurium and Staphylococcus aureus with rates of 55.6%, 38.0% and 47.6%, respectively. These results demonstrate that L. plantarum Q180 has potential as a probiotic with anti-obesity effects. PMID:26761499

Membrane transport mechanisms of choline in human intestinal epithelial LS180 cells.

PubMed

Horie, Asuka; Ishida, Kazuya; Watanabe, Yuri; Shibata, Kaito; Hashimoto, Yukiya

2014-12-01

The aim of the present study was to investigate the membrane transport mechanisms of choline using human intestinal epithelial LS180 cells. The mRNA of choline transporter-like proteins (CTLs) was expressed significantly in LS180 cells, and the rank order was CTL1 > CTL4 > CTL3 > CTL2 > CTL5. In contrast, the mRNA expression of other choline transporters, organic cation transporter (OCT) 1, OCT2 and high-affinity choline transporter 1 (CHT1), was considerably lower in LS180 cells. Five mm unlabelled choline, hemicolinium-3 and guanidine, but not tetraethylammonium, inhibited the cellular uptake of 100 µm choline in LS180 cells. The uptake of choline into LS180 cells was virtually Na(+)-independent. The uptake of choline was significantly decreased by acidification of the extracellular pH; however, it was not increased by alkalization of the extracellular pH. In addition, both acidification and alkalization of intracellular pH decreased the uptake of choline, indicating that the choline uptake in LS180 cells is not stimulated by the outward H(+) gradient. On the other hand, the uptake of choline was decreased by membrane depolarization along with increasing extracellular K(+) concentration. In addition, the Na(+)-independent uptake of choline was saturable, and the Km value was estimated to be 108 µm. These findings suggest that the uptake of choline into LS180 cells is membrane potential-dependent, but not outward H(+) gradient-dependent. Copyright © 2014 John Wiley & Sons, Ltd.

The analysis of QT interval and repolarization morphology of the heart in chronic exposure to lead.

PubMed

Kiełtucki, J; Dobrakowski, M; Pawlas, N; Średniawa, B; Boroń, M; Kasperczyk, S

2017-10-01

There are no common recommendations regarding electrocardiographic monitoring in occupationally exposed workers. Therefore, the present study was designed to investigate whether exposure to lead results in an increase of selected electrocardiography (ECG) pathologies, such as QT interval prolongation and repolarization disorders, in occupationally exposed workers. The study group included 180 workers occupationally exposed to lead compounds. The exposed group was divided according to the median of the mean blood lead level (PbB mean ) calculated based on a series of measurements performed during 5-year observation period (35 µg/dl) into two subgroups: low exposure (LE, PbB mean = 20.0-35.0 µg/dl) and high exposure (HE, PbB mean = 35.1-46.4 µg/dl). The control group consisted of 69 healthy workers without occupational exposure to lead. ECG evaluation included the analysis of heart rate (HR), QT interval and repolarization abnormalities. Mean QT interval was significantly greater in the exposed population than in the control group by 2%. In the HE group, mean QT interval was significantly greater than in the control group by 4% and significantly different from those noted in the LE group. Positive correlations between QT interval and lead exposure indices were also reported. Besides, there was a negative correlation between HR and blood lead level. Increased concentration of lead in the blood above 35 μg/dl is associated with the QT interval prolongation, which may trigger arrhythmias when combined with other abnormalities, such as long QT syndrome. Therefore, electrocardiographic evaluation should be a part of a routine monitoring of occupationally exposed populations.

40 CFR 180.200 - Dicloran; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

....200 Section 180.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.200... None Endive 10 None Garlic 5 None Grape 10 None Lettuce 10 None Nectarine, postharvest 20 None Onion 10...

40 CFR 180.261 - Phosmet; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Phosmet; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.261 Phosmet; tolerances for residues. (a) General. Tolerances are established for residues of the insecticide...

40 CFR 180.503 - Cymoxanil, tolerance for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Cymoxanil, tolerance for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.503 Cymoxanil, tolerance for residues. (a) General. Tolerances are established for residues of the fungicide...

40 CFR 180.567 - Zoxamide; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Zoxamide; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.567 Zoxamide; tolerances for residues. (a) General. (1) Tolerances are established for residues of zoxamide (3...

40 CFR 180.567 - Zoxamide; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Zoxamide; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.567 Zoxamide; tolerances for residues. (a) General. (1) Tolerances are established for residues of zoxamide (3...

2 CFR 180.200 - What is a covered transaction?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What is a covered transaction? 180.200 Section 180.200 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION...

2 CFR 180.210 - Which nonprocurement transactions are covered transactions?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Which nonprocurement transactions are covered transactions? 180.210 Section 180.210 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

2 CFR 180.40 - How are these guidelines maintained?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How are these guidelines maintained? 180.40 Section 180.40 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION...

2 CFR 180.510 - Who maintains the EPLS?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Who maintains the EPLS? 180.510 Section 180.510 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT...

40 CFR 180.2020 - Non-food determinations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Non-food determinations. 180.2020... TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From a Tolerance § 180.2020 Non-food determinations. The following pesticide...

40 CFR 180.2020 - Non-food determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Non-food determinations. 180.2020... TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From a Tolerance § 180.2020 Non-food determinations. The following pesticide...

40 CFR 180.2020 - Non-food determinations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Non-food determinations. 180.2020... TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From a Tolerance § 180.2020 Non-food determinations. The following pesticide...

40 CFR 180.2020 - Non-food determinations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Non-food determinations. 180.2020... TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From a Tolerance § 180.2020 Non-food determinations. The following pesticide...

40 CFR 180.2020 - Non-food determinations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Non-food determinations. 180.2020... TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From a Tolerance § 180.2020 Non-food determinations. The following pesticide...

2 CFR 180.900 - Adequate evidence.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Adequate evidence. 180.900 Section 180.900 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Adequate evidence. Adequate evidence means information sufficient to support the reasonable belief that a...

2 CFR 180.900 - Adequate evidence.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Adequate evidence. 180.900 Section 180.900 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF.... Adequate evidence means information sufficient to support the reasonable belief that a particular act or...

2 CFR 180.900 - Adequate evidence.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Adequate evidence. 180.900 Section 180.900 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF... Adequate evidence. Adequate evidence means information sufficient to support the reasonable belief that a...

2 CFR 180.900 - Adequate evidence.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Adequate evidence. 180.900 Section 180.900 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF.... Adequate evidence means information sufficient to support the reasonable belief that a particular act or...

49 CFR 180.511 - Acceptable results of inspections and tests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Acceptable results of inspections and tests. 180.511 Section 180.511 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE... results of inspections and tests. Provided it conforms to other applicable requirements of this subchapter...

49 CFR 180.511 - Acceptable results of inspections and tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Acceptable results of inspections and tests. 180.511 Section 180.511 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE... results of inspections and tests. Provided it conforms to other applicable requirements of this subchapter...

49 CFR 180.511 - Acceptable results of inspections and tests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Acceptable results of inspections and tests. 180.511 Section 180.511 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... results of inspections and tests. Provided it conforms with other applicable requirements of this...

2 CFR 180.860 - What factors may influence the debarring official's decision?

Code of Federal Regulations, 2010 CFR

2010-01-01

... not necessarily determinative of your present responsibility. In making a debarment decision, the... official's decision? 180.860 Section 180.860 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET...'s decision? This section lists the mitigating and aggravating factors that the debarring official...

7 CFR 28.180 - Issuance of cotton classification memoranda.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Issuance of cotton classification memoranda. 28.180... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.180 Issuance of cotton classification memoranda. As soon as practicable after the classification or...

7 CFR 28.180 - Issuance of cotton classification memoranda.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false Issuance of cotton classification memoranda. 28.180... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.180 Issuance of cotton classification memoranda. As soon as practicable after the classification or...

7 CFR 28.180 - Issuance of cotton classification memoranda.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Issuance of cotton classification memoranda. 28.180... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.180 Issuance of cotton classification memoranda. As soon as practicable after the classification or...

7 CFR 28.180 - Issuance of cotton classification memoranda.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Issuance of cotton classification memoranda. 28.180... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.180 Issuance of cotton classification memoranda. As soon as practicable after the classification or...

7 CFR 28.180 - Issuance of cotton classification memoranda.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Issuance of cotton classification memoranda. 28.180... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.180 Issuance of cotton classification memoranda. As soon as practicable after the classification or...

21 CFR 180.22 - Acrylonitrile copolymers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Acrylonitrile copolymers. 180.22 Section 180.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, or available for inspection at...

21 CFR 180.22 - Acrylonitrile copolymers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Acrylonitrile copolymers. 180.22 Section 180.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, or available for inspection at...

21 CFR 180.22 - Acrylonitrile copolymers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Acrylonitrile copolymers. 180.22 Section 180.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, or available for inspection at...

21 CFR 180.22 - Acrylonitrile copolymers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Acrylonitrile copolymers. 180.22 Section 180.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, or available for inspection at...

2 CFR 180.915 - Civil judgment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Civil judgment. 180.915 Section 180.915... Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction, whether by verdict, decision, settlement, stipulation, other disposition which creates a civil...

2 CFR 180.915 - Civil judgment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Civil judgment. 180.915 Section 180.915... Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction, whether by verdict, decision, settlement, stipulation, other disposition which creates a civil...

Method of controlling switching of a multiphase inductor-converter bridge

DOEpatents

Kustom, Robert L.; Fuja, Raymond E.

1981-01-01

In an inductor-convertor circuit for transferring electrical energy between a storage coil and a load coil using a storage thyristor bridge, a load thyristor bridge, and a set of commutating capacitors, operation is improved by a method of changing the rate of delivery of energy in a given direction. The change in rate corresponds to a predetermined change in phase angle between the load bridge and the storage bridge and comprises changing the phase of the bridge by two steps, each equal to half the predetermined change and occurring 180.degree. apart. The method assures commutation and minimizes imbalances that lead otherwise to overvoltages.

Development of a preprototype vapor compression distillation water recovery subsystem

NASA Technical Reports Server (NTRS)

Johnson, K. L.

1978-01-01

The activities involved in the design, development, and test of a preprototype vapor compression distillation water recovery subsystem are described. This subsystem, part of a larger regenerative life support evaluation system, is designed to recover usable water from urine, urinal rinse water, and concentrated shower and laundry brine collected from three space vehicle crewmen for a period of 180 days without resupply. Details of preliminary design and testing as well as component developments are included. Trade studies, considerations leading to concept selections, problems encountered, and test data are also presented. The rework of existing hardware, subsystem development including computer programs, assembly verification, and comprehensive baseline test results are discussed.

Hypertensive Crisis From the Aquamantys Bipolar Sealing System.

PubMed

Hardy, Brian C; Giordano, Christopher R

2016-12-15

Hypertension is a common occurrence during general anesthesia. Apart from pathological causes of hypertension, it is rarely extreme enough to be classified as a hypertensive crisis (systolic blood pressure >180 mm Hg or diastolic blood pressure >120 mm Hg). There is literature concerning the unintentional electrocauterization of the adrenal gland leading to hypertensive crisis, but to date, no reports have been made of adrenal stimulation from the use of an Aquamantys for hemostasis. Here, we report such a case when a hypertensive crisis (systolic blood pressure >300 mm Hg) occurred while using an Aquamantys during a liver transplant after unintentional stimulation of the adrenal glands.

Read 180®. What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2016

2016-01-01

"READ 180®" is a reading program designed for struggling readers who are reading 2 or more years below grade level. It combines online and direct instruction, student assessment, and teacher professional development. "READ 180®" is delivered in 90-minute sessions that include whole-group instruction, three small-group…

40 CFR 180.303 - Oxamyl; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

....303 Section 180.303 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.303..., undelinted seed 0.2 Cucumber 2.0 Eggplant 2.0 Fruit, citrus, group 10 3 Garlic, bulb 0.2 Melon, honeydew 2.0...

40 CFR 180.303 - Oxamyl; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

....303 Section 180.303 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.303..., undelinted seed 0.2 Cucumber 2.0 Eggplant 2.0 Fruit, citrus, group 10 3 Garlic, bulb 0.2 Melon, honeydew 2.0...

24 CFR 1720.180 - Settlements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Settlements. 1720.180 Section 1720... Proceedings General Provisions § 1720.180 Settlements. Parties may propose in writing, at any time during the course of a proceeding, offers of settlement which shall be submitted to the Secretary. If determined to...

19 CFR 10.180 - Certification.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Certification. 10.180 Section 10.180 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the exporting country and filed with Customs with the entry summary or with the entry when the entry...

19 CFR 10.180 - Certification.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certification. 10.180 Section 10.180 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the exporting country and filed with Customs with the entry summary or with the entry when the entry...

19 CFR 10.180 - Certification.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Certification. 10.180 Section 10.180 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the exporting country and filed with Customs with the entry summary or with the entry when the entry...

19 CFR 10.180 - Certification.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Certification. 10.180 Section 10.180 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the exporting country and filed with Customs with the entry summary or with the entry when the entry...

19 CFR 10.180 - Certification.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Certification. 10.180 Section 10.180 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the exporting country and filed with Customs with the entry summary or with the entry when the entry...

49 CFR 180.603 - Qualification of portable tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Qualification of portable tanks. 180.603 Section... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Portable Tanks § 180.603 Qualification of portable tanks. (a) Each portable tank used for the transportation of hazardous materials must be an authorized...

9 CFR 592.180 - Suspension of plant approval.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Suspension of plant approval. 592.180 Section 592.180 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE..., and all labels, seals, tags, or packaging material bearing official identification shall, under the...

2 CFR 180.10 - How is this part organized?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How is this part organized? 180.10 Section 180.10 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND... nonprocurement debarment and suspension system; (2) The effects of an exclusion under that nonprocurement system...

2 CFR 180.15 - To whom does the guidance apply?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false To whom does the guidance apply? 180.15 Section 180.15 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION...

40 CFR 180.1016 - Ethylene; exemption from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Ethylene; exemption from the requirement of a tolerance. 180.1016 Section 180.1016 Protection of Environment ENVIRONMENTAL PROTECTION..., soybean, squash, tomato, turnip, and watermelon fields as part of the U.S. Department of Agriculture...

49 CFR 572.137 - Test conditions and instrumentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

...—Class 1000 (2) Neck: (i) Forces—Class 1000 (ii) Moments—Class 600 (iii) Pendulum acceleration—Class 180... and pendulum accelerations—Class 180 (iii) Sternum deflection—Class 600 (iv) Forces—Class 1000 (v...—Class 180 (6) Femur forces and knee pendulum—Class 600 (n) Coordinate signs for instrumentation polarity...

49 CFR 572.137 - Test conditions and instrumentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

...—Class 1000 (2) Neck: (i) Forces—Class 1000 (ii) Moments—Class 600 (iii) Pendulum acceleration—Class 180... and pendulum accelerations—Class 180 (iii) Sternum deflection—Class 600 (iv) Forces—Class 1000 (v...—Class 180 (6) Femur forces and knee pendulum—Class 600 (n) Coordinate signs for instrumentation polarity...

49 CFR 572.137 - Test conditions and instrumentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

...—Class 1000 (2) Neck: (i) Forces—Class 1000 (ii) Moments—Class 600 (iii) Pendulum acceleration—Class 180... and pendulum accelerations—Class 180 (iii) Sternum deflection—Class 600 (iv) Forces—Class 1000 (v...—Class 180 (6) Femur forces and knee pendulum—Class 600 (n) Coordinate signs for instrumentation polarity...

49 CFR 572.137 - Test conditions and instrumentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

...—Class 1000 (2) Neck: (i) Forces—Class 1000 (ii) Moments—Class 600 (iii) Pendulum acceleration—Class 180... and pendulum accelerations—Class 180 (iii) Sternum deflection—Class 600 (iv) Forces—Class 1000 (v...—Class 180 (6) Femur forces and knee pendulum—Class 600 (n) Coordinate signs for instrumentation polarity...

49 CFR 572.137 - Test conditions and instrumentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

...—Class 1000 (2) Neck: (i) Forces—Class 1000 (ii) Moments—Class 600 (iii) Pendulum acceleration—Class 180... and pendulum accelerations—Class 180 (iii) Sternum deflection—Class 600 (iv) Forces—Class 1000 (v...—Class 180 (6) Femur forces and knee pendulum—Class 600 (n) Coordinate signs for instrumentation polarity...

2 CFR 180.600 - How do suspension and debarment actions start?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How do suspension and debarment actions start? 180.600 Section 180.600 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND...

2 CFR 180.620 - Do Federal agencies coordinate suspension and debarment actions?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Do Federal agencies coordinate suspension and debarment actions? 180.620 Section 180.620 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT...

2 CFR 180.840 - How is fact-finding conducted?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How is fact-finding conducted? 180.840 Section 180.840 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS... present witnesses and other evidence, and confront any witness presented; and (2) The fact-finder must...

2 CFR 180.720 - How may I contest a suspension?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How may I contest a suspension? 180.720 Section 180.720 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS Reserved OMB GUIDELINES TO AGENCIES ON GOVERNMENTWIDE DEBARMENT AND SUSPENSION...

24 CFR 180.515 - Depositions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Depositions. 180.515 Section 180... Depositions. (a) Notice. Upon written notice to the witness and to all other parties, a party may take the testimony of a witness by deposition and may request the production of specified documents or materials by...

24 CFR 180.515 - Depositions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Depositions. 180.515 Section 180... Depositions. (a) Notice. Upon written notice to the witness and to all other parties, a party may take the testimony of a witness by deposition and may request the production of specified documents or materials by...

21 CFR 225.180 - Labeling.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Labeling. 225.180 Section 225.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... be adequately labeled to assure that the feed can be properly used. [51 FR 7390, Mar. 3, 1986] ...

40 CFR 180.29 - Establishment, modification, and revocation of tolerance on initiative of Administrator.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Establishment, modification, and revocation of tolerance on initiative of Administrator. 180.29 Section 180.29 Protection of Environment... on initiative of Administrator. (a) Upon the Administrator's own initiative, the Administrator may...

45 CFR 148.180 - Prohibition of discrimination based on genetic information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... minimum amount of information necessary to make a decision regarding payment. Because the results of the... making a determination regarding the medical appropriateness of a claim if the genetic information is... information. 148.180 Section 148.180 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS...

49 CFR 180.411 - Acceptable results of tests and inspections.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Acceptable results of tests and inspections. 180.411 Section 180.411 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE... results of tests and inspections. (a) Corroded or abraded areas. The minimum thickness may not be less...

49 CFR 180.411 - Acceptable results of tests and inspections.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Acceptable results of tests and inspections. 180.411 Section 180.411 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE... results of tests and inspections. (a) Corroded or abraded areas. The minimum thickness may not be less...

49 CFR 180.411 - Acceptable results of tests and inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Acceptable results of tests and inspections. 180.411 Section 180.411 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... results of tests and inspections. (a) Corroded or abraded areas. The minimum thickness may not be less...

24 CFR 180.410 - Charges under the Fair Housing Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Charges under the Fair Housing Act. 180.410 Section 180.410 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

24 CFR 180.635 - Written testimony.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Written testimony. 180.635 Section... § 180.635 Written testimony. The ALJ may accept and enter into the record direct testimony of witnesses made by verified written statement rather than by oral presentation at the hearing. Unless the ALJ...

42 CFR 440.180 - Home or community-based services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Home or community-based services. 440.180 Section... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Definitions § 440.180 Home or community-based services. (a) Description and requirements for services. “Home or community-based services...

42 CFR 440.180 - Home or community-based services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 4 2013-10-01 2013-10-01 false Home or community-based services. 440.180 Section... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Definitions § 440.180 Home or community-based services. (a) Description and requirements for services. “Home or community-based services...

42 CFR 440.180 - Home or community-based services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 4 2012-10-01 2012-10-01 false Home or community-based services. 440.180 Section... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Definitions § 440.180 Home or community-based services. (a) Description and requirements for services. “Home or community-based services...

42 CFR 460.180 - Medicare payment to PACE organizations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Medicare payment to PACE organizations. 460.180... FOR THE ELDERLY (PACE) Payment § 460.180 Medicare payment to PACE organizations. (a) Principle of payment. Under a PACE program agreement, CMS makes a prospective monthly payment to the PACE organization...

40 CFR 180.185 - DCPA; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 180.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.185 DCPA...: Commodity Parts per million Basil, dried leaves 20.0 Basil, fresh leaves 5.0 Bean, dry 2.0 Bean, mung, seed...

40 CFR 180.185 - DCPA; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 180.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.185 DCPA...: Commodity Parts per million Basil, dried leaves 20.0 Basil, fresh leaves 5.0 Bean, dry 2.0 Bean, mung, seed...

40 CFR 180.185 - DCPA; tolerances for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 180.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.185 DCPA...: Commodity Parts per million Basil, dried leaves 20.0 Basil, fresh leaves 5.0 Bean, dry 2.0 Bean, mung, seed...

40 CFR 180.185 - DCPA; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 180.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.185 DCPA...: Commodity Parts per million Basil, dried leaves 20.0 Basil, fresh leaves 5.0 Bean, dry 2.0 Bean, mung, seed...

40 CFR 180.185 - DCPA; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 180.185 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.185 DCPA...: Commodity Parts per million Basil, dried leaves 20.0 Basil, fresh leaves 5.0 Bean, dry 2.0 Bean, mung, seed...

21 CFR 131.180 - Half-and-half.

Code of Federal Regulations, 2010 CFR

2010-04-01

...). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The milkfat content is determined... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Half-and-half. 131.180 Section 131.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 131.180 - Half-and-half.

Code of Federal Regulations, 2013 CFR

2013-04-01

...). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The milkfat content is determined... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Half-and-half. 131.180 Section 131.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 131.180 - Half-and-half.

Code of Federal Regulations, 2014 CFR

2014-04-01

...). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The milkfat content is determined... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Half-and-half. 131.180 Section 131.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 160.180 - Egg yolks.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Egg yolks. 160.180 Section 160.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... the method prescribed in “Official Methods of Analysis of the Association of Official Analytical...

21 CFR 180.22 - Acrylonitrile copolymers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... extraction for finished food-contact articles, determined by a method of analysis titled “Gas-Solid... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Acrylonitrile copolymers. 180.22 Section 180.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD...

21 CFR 131.180 - Half-and-half.

Code of Federal Regulations, 2011 CFR

2011-04-01

...). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The milkfat content is determined... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Half-and-half. 131.180 Section 131.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 131.180 - Half-and-half.

Code of Federal Regulations, 2012 CFR

2012-04-01

...). (ii) Natural and artificial food flavoring. (c) Methods of analysis. The milkfat content is determined... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Half-and-half. 131.180 Section 131.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

27 CFR 19.180 - Application for amended registration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Application for amended registration. 19.180 Section 19.180 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... current. Where the change affects only pages or parts of pages of the notice of registration, such...

9 CFR 381.180 - Information and reports required from official establishment operators.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Information and reports required from official establishment operators. 381.180 Section 381.180 Animals and Animal Products FOOD SAFETY AND... concerning sanitation, mandatory microbiological testing, and other aspects of the operations of the...

9 CFR 381.180 - Information and reports required from official establishment operators.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Information and reports required from official establishment operators. 381.180 Section 381.180 Animals and Animal Products FOOD SAFETY AND... concerning sanitation, mandatory microbiological testing, and other aspects of the operations of the...

9 CFR 381.180 - Information and reports required from official establishment operators.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Information and reports required from official establishment operators. 381.180 Section 381.180 Animals and Animal Products FOOD SAFETY AND... concerning sanitation, mandatory microbiological testing, and other aspects of the operations of the...

9 CFR 381.180 - Information and reports required from official establishment operators.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Information and reports required from official establishment operators. 381.180 Section 381.180 Animals and Animal Products FOOD SAFETY AND... concerning sanitation, mandatory microbiological testing, and other aspects of the operations of the...

9 CFR 381.180 - Information and reports required from official establishment operators.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Information and reports required from official establishment operators. 381.180 Section 381.180 Animals and Animal Products FOOD SAFETY AND... concerning sanitation, mandatory microbiological testing, and other aspects of the operations of the...

24 CFR 180.405 - Time computations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time computations. 180.405 Section... Hearing § 180.405 Time computations. (a) In computing time under this part, the time period begins the day... Saturday, Sunday, or legal holiday observed by the Federal Government, in which case the time period...

24 CFR 180.405 - Time computations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time computations. 180.405 Section... Hearing § 180.405 Time computations. (a) In computing time under this part, the time period begins the day... Saturday, Sunday, or legal holiday observed by the Federal Government, in which case the time period...

45 CFR 146.180 - Treatment of non-Federal governmental plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

....180 Section 146.180 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Exclusion of Plans and Enforcement... plan is not provided through health insurance coverage, (that is, it is self-funded), from any or all...

45 CFR 146.180 - Treatment of non-Federal governmental plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

....180 Section 146.180 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Exclusion of Plans and Enforcement... section 2701 of the PHS Act as codified before enactment of the Affordable Care Act. (ii) Special...

42 CFR 440.180 - Home or community-based services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Home or community-based services. 440.180 Section 440.180 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... community-based services. (a) Description and requirements for services. “Home or community-based services...

2 CFR 180.740 - Are suspension proceedings formal?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Are suspension proceedings formal? 180.740 Section 180.740 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS... suspension decision. (b) You as a respondent or your representative must submit any documentary evidence you...

2 CFR 180.835 - Are debarment proceedings formal?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Are debarment proceedings formal? 180.835 Section 180.835 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS... the decision whether to debar. (b) You or your representative must submit any documentary evidence you...

40 CFR 180.209 - Terbacil; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

....209 Section 180.209 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.209..., hay 2.0 Apple 0.3 Asparagus 0.4 Blueberry 0.2 Caneberry subgroup 13A 0.2 Peach 0.2 Peppermint, tops 2...

40 CFR 180.209 - Terbacil; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

....209 Section 180.209 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.209..., hay 2.0 Apple 0.3 Asparagus 0.4 Blueberry 0.2 Caneberry subgroup 13A 0.2 Peach 0.2 Peppermint, tops 2...

21 CFR 180.30 - Brominated vegetable oil.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Brominated vegetable oil. 180.30 Section 180.30 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED IN FOOD OR IN CONTACT WITH FOOD ON AN...

21 CFR 180.25 - Mannitol.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Mannitol. 180.25 Section 180.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED IN FOOD OR IN CONTACT WITH FOOD ON AN INTERIM BASIS PENDING...

40 CFR 180.2010 - Threshold of regulation determinations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Threshold of regulation determinations. 180.2010 Section 180.2010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From...

40 CFR 180.2010 - Threshold of regulation determinations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Threshold of regulation determinations. 180.2010 Section 180.2010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Pesticide Chemicals Not Requiring a Tolerance or an Exemption From...

Miniature MMIC Low Mass/Power Radiometer Modules for the 180 GHz GeoSTAR Array

NASA Technical Reports Server (NTRS)

Kangaslahti, Pekka; Tanner, Alan; Pukala, David; Lambrigtsen, Bjorn; Lim, Boon; Mei, Xiaobing; Lai, Richard

2010-01-01

We have developed and demonstrated miniature 180 GHz Monolithic Microwave Integrated Circuit (MMIC) radiometer modules that have low noise temperature, low mass and low power consumption. These modules will enable the Geostationary Synthetic Thinned Aperture Radiometer (GeoSTAR) of the Precipitation and All-weather Temperature and Humidity (PATH) Mission for atmospheric temperature and humidity profiling. The GeoSTAR instrument has an array of hundreds of receivers. Technology that was developed included Indium Phosphide (InP) MMIC Low Noise Amplifiers (LNAs) and second harmonic MMIC mixers and I-Q mixers, surface mount Multi-Chip Module (MCM) packages at 180 GHz, and interferometric array at 180 GHz. A complete MMIC chip set for the 180 GHz receiver modules (LNAs and I-Q Second harmonic mixer) was developed. The MMIC LNAs had more than 50% lower noise temperature (NT=300K) than previous state-of-art and MMIC I-Q mixers demonstrated low LO power (3 dBm). Two lots of MMIC wafers were processed with very high DC transconductance of up to 2800 mS/mm for the 35 nm gate length devices. Based on these MMICs a 180 GHz Multichip Module was developed that had a factor of 100 lower mass/volume (16x18x4.5 mm3, 3g) than previous generation 180 GHz receivers.