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Sample records for lead 181

  1. 40 CFR 98.181 - Reporting threshold.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) MANDATORY GREENHOUSE GAS REPORTING Lead Production § 98.181 Reporting threshold. You must report GHG emissions under this subpart if your facility contains a lead production process and the facility meets...

  2. 40 CFR 98.181 - Reporting threshold.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) MANDATORY GREENHOUSE GAS REPORTING Lead Production § 98.181 Reporting threshold. You must report GHG emissions under this subpart if your facility contains a lead production process and the facility meets...

  3. Lead

    MedlinePlus

    ... Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home Find a Lead-Safe Certified firm Before you renovate Before you buy or rent a home built before 1978 Test your home's drinking water Test for lead in paint, dust or soil ...

  4. Lead

    MedlinePlus

    ... ATSDR Board of Scientific Counselors Lead in the environment: Agency for Toxic Substances and Disease Registry (ATSDR) Federal partner agencies: Department of Housing and Urban Development (HUD) and U.S. Environmental Protection Agency (EPA) Data, ...

  5. C-Cr-Fe (181)

    NASA Astrophysics Data System (ADS)

    Carow-Watamura, U.; Louzguine, D. V.; Takeuchi, A.

    This document is part of Part 2 http://dx.doi.org/10.1007/97.etType="URL"/> 'Systems from B-Be-Fe to Co-W-Zr' of Subvolume B 'Physical Properties of Ternary Amorphous Alloys' of Volume 37 'Phase Diagrams and Physical Properties of Nonequilibrium Alloys' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains the Chapter 'C-Cr-Fe (181)' with the content:

  6. 24 CFR 18.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Policy. 18.1 Section 18.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development INDEMNIFICATION OF HUD EMPLOYEES § 18.1 Policy. (a) The Department of Housing and Urban Development may...

  7. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  8. 46 CFR 201.181 - General matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false General matters. 201.181 Section 201.181 Shipping... PROCEDURE Judicial Standards of Practice (Rule 19) § 201.181 General matters. (a) In general, the functions... after notice and opportunity for hearing, or in the case of other matters from the time of notice by...

  9. 46 CFR 201.181 - General matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false General matters. 201.181 Section 201.181 Shipping... PROCEDURE Judicial Standards of Practice (Rule 19) § 201.181 General matters. (a) In general, the functions... after notice and opportunity for hearing, or in the case of other matters from the time of notice by...

  10. 46 CFR 201.181 - General matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false General matters. 201.181 Section 201.181 Shipping... PROCEDURE Judicial Standards of Practice (Rule 19) § 201.181 General matters. (a) In general, the functions... after notice and opportunity for hearing, or in the case of other matters from the time of notice by...

  11. 46 CFR 201.181 - General matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false General matters. 201.181 Section 201.181 Shipping... PROCEDURE Judicial Standards of Practice (Rule 19) § 201.181 General matters. (a) In general, the functions... after notice and opportunity for hearing, or in the case of other matters from the time of notice by...

  12. 46 CFR 201.181 - General matters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false General matters. 201.181 Section 201.181 Shipping... PROCEDURE Judicial Standards of Practice (Rule 19) § 201.181 General matters. (a) In general, the functions... after notice and opportunity for hearing, or in the case of other matters from the time of notice by...

  13. 10 CFR 60.181 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Violations. 60.181 Section 60.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Violations § 60.181 Violations. (a) The Commission may obtain an injunction or other court order to prevent...

  14. 10 CFR 60.181 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Violations. 60.181 Section 60.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Violations § 60.181 Violations. (a) The Commission may obtain an injunction or other court order to prevent...

  15. 10 CFR 60.181 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Violations. 60.181 Section 60.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Violations § 60.181 Violations. (a) The Commission may obtain an injunction or other court order to prevent...

  16. 10 CFR 60.181 - Violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Violations. 60.181 Section 60.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Violations § 60.181 Violations. (a) The Commission may obtain an injunction or other court order to prevent...

  17. 10 CFR 60.181 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Violations. 60.181 Section 60.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Violations § 60.181 Violations. (a) The Commission may obtain an injunction or other court order to prevent...

  18. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in...

  19. 46 CFR 181.610 - Fire bucket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire bucket. 181.610 Section 181.610 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.610 Fire bucket. A vessel not required to have a power...

  20. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  1. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in...

  2. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in...

  3. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in...

  4. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  5. 46 CFR 181.610 - Fire bucket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fire bucket. 181.610 Section 181.610 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.610 Fire bucket. A vessel not required to have a power...

  6. 46 CFR 181.610 - Fire bucket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fire bucket. 181.610 Section 181.610 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.610 Fire bucket. A vessel not required to have a power...

  7. 46 CFR 181.610 - Fire bucket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fire bucket. 181.610 Section 181.610 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.610 Fire bucket. A vessel not required to have a power...

  8. 46 CFR 181.610 - Fire bucket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fire bucket. 181.610 Section 181.610 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.610 Fire bucket. A vessel not required to have a power...

  9. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  10. 46 CFR 181.600 - Fire axe.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fire axe. 181.600 Section 181.600 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Additional Equipment § 181.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in...

  11. 38 CFR 18.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Purpose. 18.1 Section 18.1 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... THE CIVIL RIGHTS ACT OF 1964 General § 18.1 Purpose. The purpose of this part is to effectuate...

  12. 28 CFR 18.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Purpose. 18.1 Section 18.1 Judicial Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.1 Purpose. The purpose of this regulation is to implement the hearing and appeal procedures available to State block...

  13. 14 CFR 23.181 - Dynamic stability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Dynamic stability. 23.181 Section 23.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Stability § 23.181 Dynamic stability. (a) Any short...

  14. 14 CFR 23.181 - Dynamic stability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Dynamic stability. 23.181 Section 23.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Stability § 23.181 Dynamic stability. (a) Any short...

  15. 14 CFR 23.181 - Dynamic stability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Dynamic stability. 23.181 Section 23.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Stability § 23.181 Dynamic stability. Link to an...

  16. 5 CFR 550.181 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 550.181 Section 550.181 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.181 Coverage. (a) Each employee meeting the...

  17. 5 CFR 550.181 - Coverage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 550.181 Section 550.181 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.181 Coverage. (a) Each employee meeting the...

  18. 5 CFR 550.181 - Coverage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 550.181 Section 550.181 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.181 Coverage. (a) Each employee meeting the...

  19. 5 CFR 550.181 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 550.181 Section 550.181 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.181 Coverage. (a) Each employee meeting the...

  20. 5 CFR 550.181 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 550.181 Section 550.181 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.181 Coverage. (a) Each employee meeting the...

  1. 50 CFR 300.181 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Definitions. 300.181 Section 300.181... International Trade Documentation and Tracking Programs for Highly Migratory Species § 300.181 Definitions... definition. Entry number, for purposes of this subpart, means the unique number/identifier assigned...

  2. 19 CFR 181.132 - Disassembly.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Disassembly. 181.132 Section 181.132 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Rules of Origin § 181.132 Disassembly. (a) Treated...

  3. 19 CFR 181.132 - Disassembly.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Disassembly. 181.132 Section 181.132 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Rules of Origin § 181.132 Disassembly. (a) Treated...

  4. 19 CFR 181.63 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false 181.63 Section 181.63 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Commercial Samples and Goods Returned After Repair or Alteration § 181.63...

  5. 19 CFR 181.32 - Filing procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Filing procedures. 181.32 Section 181.32 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Post-Importation Duty Refund Claims § 181.32...

  6. 19 CFR 181.132 - Disassembly.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Disassembly. 181.132 Section 181.132 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Rules of Origin § 181.132 Disassembly. (a) Treated...

  7. 19 CFR 181.32 - Filing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Filing procedures. 181.32 Section 181.32 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Post-Importation Duty Refund Claims § 181.32...

  8. 19 CFR 181.132 - Disassembly.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Disassembly. 181.132 Section 181.132 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Rules of Origin § 181.132 Disassembly. (a) Treated...

  9. 49 CFR 37.181 - Applicability dates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Applicability dates. 37.181 Section 37.181 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.181 Applicability dates. This subpart applies to...

  10. 49 CFR 37.181 - Applicability dates.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Applicability dates. 37.181 Section 37.181 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.181 Applicability dates. This subpart applies to...

  11. 49 CFR 37.181 - Applicability dates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Applicability dates. 37.181 Section 37.181 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.181 Applicability dates. This subpart applies to...

  12. 49 CFR 37.181 - Applicability dates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Applicability dates. 37.181 Section 37.181 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.181 Applicability dates. This subpart applies to...

  13. 49 CFR 37.181 - Applicability dates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Applicability dates. 37.181 Section 37.181 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.181 Applicability dates. This subpart applies to...

  14. 20 CFR 655.181 - Revocation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Revocation. 655.181 Section 655.181 Employees... United States (H-2A Workers) Integrity Measures § 655.181 Revocation. (a) Basis for DOL revocation. The.... (b) DOL procedures for revocation. (1) Notice of Revocation. If the OFLC Administrator makes...

  15. 22 CFR 181.8 - Publication.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Publication. 181.8 Section 181.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.8 Publication. (a) The following categories of international agreements will...

  16. 22 CFR 181.8 - Publication.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Publication. 181.8 Section 181.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.8 Publication. (a) The following categories of international agreements will...

  17. 22 CFR 181.8 - Publication.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Publication. 181.8 Section 181.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.8 Publication. (a) The following categories of international agreements will...

  18. 22 CFR 181.8 - Publication.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Publication. 181.8 Section 181.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.8 Publication. (a) The following categories of international agreements will...

  19. 30 CFR 18.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Purpose. 18.1 Section 18.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES General Provisions § 18.1 Purpose....

  20. 21 CFR 181.24 - Antioxidants.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Antioxidants. 181.24 Section 181.24 Food and Drugs... INGREDIENTS Specific Prior-Sanctioned Food Ingredients § 181.24 Antioxidants. Substances classified as antioxidants, when migrating from food-packaging material (limit of addition to food, 0.005 percent)...

  1. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD... EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must be..., the minimum capacity of the fire pump must be 189 liters (50 gallons) per minute at a pressure of...

  2. 27 CFR 44.181 - Packages.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., 2013, § 44.181 was revised, effective Aug. 26, 2013 through Aug. 26, 2016. ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Packages. 44.181 Section 44.181 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT...

  3. 14 CFR 23.181 - Dynamic stability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Dynamic stability. 23.181 Section 23.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Stability § 23.181...

  4. 14 CFR 23.181 - Dynamic stability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Dynamic stability. 23.181 Section 23.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Stability § 23.181...

  5. 27 CFR 479.181 - Penalties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Penalties. 479.181 Section 479.181 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER...

  6. 27 CFR 479.181 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Penalties. 479.181 Section 479.181 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER...

  7. 27 CFR 479.181 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Penalties. 479.181 Section 479.181 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER...

  8. 27 CFR 479.181 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Penalties. 479.181 Section 479.181 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER...

  9. 27 CFR 479.181 - Penalties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Penalties. 479.181 Section 479.181 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN OTHER...

  10. 40 CFR 63.181 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Standards for Organic Hazardous Air Pollutants for Equipment Leaks § 63.181 Recordkeeping requirements. (a...: (1) Identification of the process unit(s) and the organic HAP's they handle. (2) A schematic of the... Section 63.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

  11. 40 CFR 63.181 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Standards for Organic Hazardous Air Pollutants for Equipment Leaks § 63.181 Recordkeeping requirements. (a...: (1) Identification of the process unit(s) and the organic HAP's they handle. (2) A schematic of the... Section 63.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

  12. 40 CFR 436.181 - Specialized definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Specialized definitions. 436.181 Section 436.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Phosphate Rock Subcategory §...

  13. 21 CFR 181.5 - Prior sanctions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... use of the ingredient, in order to prevent the adulteration of food in violation of section 402 of the... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Prior sanctions. 181.5 Section 181.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  14. 21 CFR 181.5 - Prior sanctions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... use of the ingredient, in order to prevent the adulteration of food in violation of section 402 of the... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Prior sanctions. 181.5 Section 181.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  15. 21 CFR 181.5 - Prior sanctions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... use of the ingredient, in order to prevent the adulteration of food in violation of section 402 of the... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Prior sanctions. 181.5 Section 181.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  16. 21 CFR 181.5 - Prior sanctions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... use of the ingredient, in order to prevent the adulteration of food in violation of section 402 of the... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Prior sanctions. 181.5 Section 181.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  17. 40 CFR 96.181 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false General. 96.181 Section 96.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR NOX Opt-in...

  18. 12 CFR 303.181 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Definitions. 303.181 Section 303.181 Banks and...) Comptroller means the Office of the Comptroller of the Currency. (c) Eligible insured branch. An insured branch will be treated as an eligible depository institution within the meaning of § 303.2(r) if...

  19. 40 CFR 421.181 - Specialized definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Specialized definitions. 421.181 Section 421.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary...

  20. 40 CFR 421.181 - Specialized definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Specialized definitions. 421.181 Section 421.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary...

  1. 40 CFR 421.181 - Specialized definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Specialized definitions. 421.181 Section 421.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary...

  2. 40 CFR 421.181 - Specialized definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 421.181 Section 421.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary...

  3. 40 CFR 421.181 - Specialized definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Specialized definitions. 421.181 Section 421.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary and Secondary...

  4. 40 CFR 436.181 - Specialized definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Specialized definitions. 436.181 Section 436.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Phosphate Rock Subcategory §...

  5. 33 CFR 181.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Definitions. 181.3 Section 181.3 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY... accessory or equipment for, or appurtenance to, a boat; and (3) Any marine safety article, accessory,...

  6. 19 CFR 181.61 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Applicability. 181.61 Section 181.61 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Commercial Samples and Goods Returned After Repair...

  7. 19 CFR 181.61 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Applicability. 181.61 Section 181.61 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Commercial Samples and Goods Returned After Repair...

  8. 10 CFR 26.181 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Purpose. 26.181 Section 26.181 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness... FFD policy and for making a determination of fitness....

  9. 10 CFR 26.181 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Purpose. 26.181 Section 26.181 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness... FFD policy and for making a determination of fitness....

  10. 10 CFR 26.181 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Purpose. 26.181 Section 26.181 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness... FFD policy and for making a determination of fitness....

  11. 10 CFR 26.181 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Purpose. 26.181 Section 26.181 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness... FFD policy and for making a determination of fitness....

  12. 10 CFR 26.181 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Purpose. 26.181 Section 26.181 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness... FFD policy and for making a determination of fitness....

  13. 21 CFR 181.24 - Antioxidants.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Antioxidants. 181.24 Section 181.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Antioxidants. Substances classified as antioxidants, when migrating from food-packaging material (limit...

  14. 21 CFR 181.24 - Antioxidants.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Antioxidants. 181.24 Section 181.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Antioxidants. Substances classified as antioxidants, when migrating from food-packaging material (limit...

  15. 21 CFR 181.24 - Antioxidants.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Antioxidants. 181.24 Section 181.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Antioxidants. Substances classified as antioxidants, when migrating from food-packaging material (limit...

  16. 21 CFR 181.24 - Antioxidants.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Antioxidants. 181.24 Section 181.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Antioxidants. Substances classified as antioxidants, when migrating from food-packaging material (limit...

  17. 21 CFR 181.28 - Release agents.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Release agents. 181.28 Section 181.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PRIOR-SANCTIONED....97 at 25 °C, refractive index 1.400 to 1.404 at 25 °C). Linoleamide (linoleic acid amide)....

  18. 33 CFR 181.701 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) BOATING SAFETY MANUFACTURER REQUIREMENTS Instruction Pamphlet for Personal Flotation Devices § 181.701 Applicability. This subpart applies to all personal flotation devices that are sold or offered for sale for...

  19. 33 CFR 181.701 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) BOATING SAFETY MANUFACTURER REQUIREMENTS Instruction Pamphlet for Personal Flotation Devices § 181.701 Applicability. This subpart applies to all personal flotation devices that are sold or offered for sale for...

  20. 15 CFR 922.181 - Boundary.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National Marine Sanctuary § 922.181... Humpback Whale National Marine Sanctuary consists of the submerged lands and waters off the coast of...

  1. 15 CFR 922.181 - Boundary.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National Marine Sanctuary § 922.181... Humpback Whale National Marine Sanctuary consists of the submerged lands and waters off the coast of...

  2. 15 CFR 922.181 - Boundary.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National Marine Sanctuary § 922.181... Humpback Whale National Marine Sanctuary consists of the submerged lands and waters off the coast of...

  3. 15 CFR 922.181 - Boundary.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National Marine Sanctuary § 922.181... Humpback Whale National Marine Sanctuary consists of the submerged lands and waters off the coast of...

  4. 40 CFR 18.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.1 Definitions. As used in this... delegated. An Environmental Protection Research Fellowship is one which requires the performance of...

  5. 40 CFR 18.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.1 Definitions. As used in this... delegated. An Environmental Protection Research Fellowship is one which requires the performance of...

  6. 40 CFR 18.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.1 Definitions. As used in this... delegated. An Environmental Protection Research Fellowship is one which requires the performance of...

  7. 40 CFR 18.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.1 Definitions. As used in this... delegated. An Environmental Protection Research Fellowship is one which requires the performance of...

  8. 40 CFR 18.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL PROTECTION RESEARCH FELLOWSHIPS AND SPECIAL RESEARCH CONSULTANTS FOR ENVIRONMENTAL PROTECTION § 18.1 Definitions. As used in this... delegated. An Environmental Protection Research Fellowship is one which requires the performance of...

  9. 40 CFR 417.181 - Specialized definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.181 Specialized definitions. For the purpose of this subpart: (a) Except...

  10. 40 CFR 417.181 - Specialized definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.181 Specialized definitions. For the purpose of this subpart: (a) Except...

  11. 40 CFR 417.181 - Specialized definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.181 Specialized definitions. For the purpose of this subpart: (a) Except...

  12. 40 CFR 417.181 - Specialized definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.181 Specialized definitions. For the purpose of this subpart: (a) Except...

  13. 40 CFR 417.181 - Specialized definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Drum Dried Detergents Subcategory § 417.181 Specialized definitions. For the purpose of this subpart: (a) Except...

  14. 27 CFR 18.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Scope § 18.1 Scope. The regulations in... for the manufacture of volatile fruit-flavor concentrate (essence). The regulations in this part...

  15. 27 CFR 18.1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Scope § 18.1 Scope. The regulations in... for the manufacture of volatile fruit-flavor concentrate (essence). The regulations in this part...

  16. 14 CFR 61.181 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Instructors With a Sport Pilot Rating § 61.181 Applicability. This subpart prescribes the requirements for the... sport pilot rating), the conditions under which those certificates and ratings are necessary, and...

  17. 15 CFR 922.181 - Boundary.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Hawaiian Islands Humpback Whale National Marine Sanctuary § 922.181... Humpback Whale National Marine Sanctuary consists of the submerged lands and waters off the coast of...

  18. Alpha decay of {sup 181}Pb

    SciTech Connect

    Davids, C.N.; Henderson, D.J.; Hermann, R.

    1995-08-01

    The {alpha}-decay energy of {sup 181}Pb was measured as 7211(10) keV and 7044(15). In the first study the isotope was produced in {sup 90}Zr bombardments of {sup 94}Mo and, after traversing a velocity filter, implanted in a position-sensitive Si detector; no half life for {sup 181}Pb was reported. In the second study the isotope was produced in {sup 40}Ca bombardments of {sup 144}Sm and transported to a position in front of a Si(Au) surface barrier detector with a fast He-gas-jet capillary system; an estimate of 50 ms was determined for the {sup 181}Pb half life. Recently we investigated {sup 181}Pb {alpha} decay at ATLAS as part of a survey experiment in which a l-pnA beam of 400-MeV {sup 92}Mo was used to irradiate targets of {sup 89}Y, {sup 90,92,94}Zr, and {sup 92}Mo to examine yields for one- and two-nucleon evaporation products from symmetric cold-fusion reactions. Recoiling nuclei of interest were passed through the Fragment Mass Analyzer and implanted in a double-sided silicon strip detector for {alpha}-particle assay. With the {sup 90}Zr target we observed a group at 7065(20) keV which was correlated with A = 181 recoils and had a half life of 45(20) ms. Our new results for {sup 181}Pb therefore agreed with those of the second study. There was no indication in the {sup 90}Zr + {sup 92}Mo data of the 7211(10)-keV {alpha} particles seen by Keller et al. The interested reader is referred to the 1993 atomic mass evaluation wherein the input {alpha}-decay energies and resultant masses of the light Pb isotopes (including {sup 181}Pb) are discussed.

  19. MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin

    PubMed Central

    Di Gregoli, Karina; Mohamad Anuar, Nur Najmi; Bianco, Rosaria; White, Stephen J.; Newby, Andrew C.; George, Sarah J.

    2017-01-01

    Rationale: Atherosclerosis and aneurysms are leading causes of mortality worldwide. MicroRNAs (miRs) are key determinants of gene and protein expression, and atypical miR expression has been associated with many cardiovascular diseases; although their contributory role to atherosclerotic plaque and abdominal aortic aneurysm stability are poorly understood. Objective: To investigate whether miR-181b regulates tissue inhibitor of metalloproteinase-3 expression and affects atherosclerosis and aneurysms. Methods and Results: Here, we demonstrate that miR-181b was overexpressed in symptomatic human atherosclerotic plaques and abdominal aortic aneurysms and correlated with decreased expression of predicted miR-181b targets, tissue inhibitor of metalloproteinase-3, and elastin. Using the well-characterized mouse atherosclerosis models of Apoe−/− and Ldlr−/−, we observed that in vivo administration of locked nucleic acid anti-miR-181b retarded both the development and the progression of atherosclerotic plaques. Systemic delivery of anti-miR-181b in angiotensin II–infused Apoe−/− and Ldlr−/− mice attenuated aneurysm formation and progression within the ascending, thoracic, and abdominal aorta. Moreover, miR-181b inhibition greatly increased elastin and collagen expression, promoting a fibrotic response and subsequent stabilization of existing plaques and aneurysms. We determined that miR-181b negatively regulates macrophage tissue inhibitor of metalloproteinase-3 expression and vascular smooth muscle cell elastin production, both important factors in maintaining atherosclerotic plaque and aneurysm stability. Validation studies in Timp3−/− mice confirmed that the beneficial effects afforded by miR-181b inhibition are largely tissue inhibitor of metalloproteinase-3 dependent, while also revealing an additional protective effect through elevating elastin synthesis. Conclusions: Our findings suggest that the management of miR-181b and its target genes

  20. 19 CFR 181.122 - Disclosure to government authorities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Information § 181.122 Disclosure to government authorities. Nothing in § 181.121 of this part shall...

  1. 49 CFR 572.181 - General description.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES 2re Side Impact Crash Test Dummy, 50th Percentile Adult Male § 572.181 General description. (a) The ES-2re Side Impact Crash Test... Pelvis Assembly 175-6000 Leg Assembly, Left 175-7000-1 Leg Assembly, Right 175-7000-2 Neoprene Body...

  2. 40 CFR 61.181 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.181 Definitions. All terms used... section as follows: Arsenic kitchen means a baffled brick chamber where inorganic arsenic vapors...

  3. 40 CFR 61.181 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.181 Definitions. All terms used... section as follows: Arsenic kitchen means a baffled brick chamber where inorganic arsenic vapors...

  4. 40 CFR 61.181 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.181 Definitions. All terms used... section as follows: Arsenic kitchen means a baffled brick chamber where inorganic arsenic vapors...

  5. 40 CFR 61.181 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.181 Definitions. All terms used... section as follows: Arsenic kitchen means a baffled brick chamber where inorganic arsenic vapors...

  6. 40 CFR 61.181 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Arsenic Trioxide and Metallic Arsenic Production Facilities § 61.181 Definitions. All terms used... section as follows: Arsenic kitchen means a baffled brick chamber where inorganic arsenic vapors...

  7. 19 CFR 181.0 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) NORTH AMERICAN FREE TRADE AGREEMENT § 181.0 Scope. This part implements the duty preference and related Customs provisions applicable to imported goods under the North American Free Trade Agreement (the NAFTA) entered into on December 17, 1992, and under the North American Free Trade Agreement Implementation...

  8. 19 CFR 181.0 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) NORTH AMERICAN FREE TRADE AGREEMENT § 181.0 Scope. This part implements the duty preference and related Customs provisions applicable to imported goods under the North American Free Trade Agreement (the NAFTA) entered into on December 17, 1992, and under the North American Free Trade Agreement Implementation...

  9. 19 CFR 181.0 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) NORTH AMERICAN FREE TRADE AGREEMENT § 181.0 Scope. This part implements the duty preference and related Customs provisions applicable to imported goods under the North American Free Trade Agreement (the NAFTA) entered into on December 17, 1992, and under the North American Free Trade Agreement Implementation...

  10. 19 CFR 181.0 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) NORTH AMERICAN FREE TRADE AGREEMENT § 181.0 Scope. This part implements the duty preference and related Customs provisions applicable to imported goods under the North American Free Trade Agreement (the NAFTA) entered into on December 17, 1992, and under the North American Free Trade Agreement Implementation...

  11. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... basis, is a producer of films. X is the owner (within the meaning of § 1.181-1(a)(2)) of film ABC. X incurs production costs in year 1, but does not commence principal photography for film ABC until year 2. In year 1, X reasonably expects, based on all of the facts and circumstances, that film ABC will...

  12. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... basis, is a producer of films. X is the owner (within the meaning of § 1.181-1(a)(2)) of film ABC. X incurs production costs in year 1, but does not commence principal photography for film ABC until year 2. In year 1, X reasonably expects, based on all of the facts and circumstances, that film ABC will...

  13. 26 CFR 1.181-5 - Examples.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... basis, is a producer of films. X is the owner (within the meaning of § 1.181-1(a)(2)) of film ABC. X incurs production costs in year 1, but does not commence principal photography for film ABC until year 2. In year 1, X reasonably expects, based on all of the facts and circumstances, that film ABC will...

  14. 14 CFR 25.181 - Dynamic stability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.181 Dynamic stability. (a) Any short period... allowable speed appropriate to the configuration of the airplane must be heavily damped with the...

  15. 14 CFR 25.181 - Dynamic stability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.181 Dynamic stability. (a) Any short period... allowable speed appropriate to the configuration of the airplane must be heavily damped with the...

  16. 14 CFR 25.181 - Dynamic stability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.181 Dynamic stability. (a) Any short period... allowable speed appropriate to the configuration of the airplane must be heavily damped with the...

  17. 14 CFR 25.181 - Dynamic stability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.181 Dynamic stability. (a) Any short period... allowable speed appropriate to the configuration of the airplane must be heavily damped with the...

  18. 14 CFR 25.181 - Dynamic stability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stability § 25.181 Dynamic stability. (a) Any short period... allowable speed appropriate to the configuration of the airplane must be heavily damped with the...

  19. 26 CFR 1.181-4T - Special rules (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to § 1.181-2T(d). (2) Principal photography not commencing prior to January 1, 2009. If a taxpayer claims a deduction under section 181 with respect to a production for which principal photography...

  20. 26 CFR 1.181-4T - Special rules (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to § 1.181-2T(d). (2) Principal photography not commencing prior to January 1, 2009. If a taxpayer claims a deduction under section 181 with respect to a production for which principal photography...

  1. 10 CFR 52.181 - Duration of renewal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Duration of renewal. 52.181 Section 52.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.181 Duration of renewal. A renewed manufacturing license may be issued for a term...

  2. 10 CFR 52.181 - Duration of renewal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Duration of renewal. 52.181 Section 52.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.181 Duration of renewal. A renewed manufacturing license may be issued for a term...

  3. 10 CFR 52.181 - Duration of renewal.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Duration of renewal. 52.181 Section 52.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.181 Duration of renewal. A renewed manufacturing license may be issued for a term...

  4. 10 CFR 52.181 - Duration of renewal.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Duration of renewal. 52.181 Section 52.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.181 Duration of renewal. A renewed manufacturing license may be issued for a term...

  5. 10 CFR 52.181 - Duration of renewal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Duration of renewal. 52.181 Section 52.181 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.181 Duration of renewal. A renewed manufacturing license may be issued for a term...

  6. 33 CFR 117.181 - Oakland Inner Harbor Tidal Canal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Oakland Inner Harbor Tidal Canal. 117.181 Section 117.181 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.181 Oakland Inner Harbor Tidal Canal. The draws of the...

  7. 14 CFR 91.181 - Course to be flown.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Course to be flown. 91.181 Section 91.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 91.181 Course to be flown. Unless otherwise authorized by ATC, no person may operate an...

  8. 14 CFR 91.181 - Course to be flown.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Course to be flown. 91.181 Section 91.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 91.181 Course to be flown. Unless otherwise authorized by ATC, no person may operate an...

  9. 14 CFR 91.181 - Course to be flown.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Course to be flown. 91.181 Section 91.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 91.181 Course to be flown. Unless otherwise authorized by ATC, no person may operate an...

  10. 14 CFR 91.181 - Course to be flown.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Course to be flown. 91.181 Section 91.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 91.181 Course to be flown. Unless otherwise authorized by ATC, no person may operate an...

  11. 14 CFR 91.181 - Course to be flown.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Course to be flown. 91.181 Section 91.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 91.181 Course to be flown. Unless otherwise authorized by ATC, no person may operate an...

  12. 46 CFR 108.181 - Ventilation for enclosed spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Ventilation for enclosed spaces. 108.181 Section 108.181... AND EQUIPMENT Construction and Arrangement Ventilation § 108.181 Ventilation for enclosed spaces. (a) Each enclosed space must be vented or ventilated. (b) There must be a means to close each vent...

  13. 46 CFR 108.181 - Ventilation for enclosed spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Ventilation for enclosed spaces. 108.181 Section 108.181... AND EQUIPMENT Construction and Arrangement Ventilation § 108.181 Ventilation for enclosed spaces. (a) Each enclosed space must be vented or ventilated. (b) There must be a means to close each vent...

  14. 46 CFR 108.181 - Ventilation for enclosed spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Ventilation for enclosed spaces. 108.181 Section 108.181... AND EQUIPMENT Construction and Arrangement Ventilation § 108.181 Ventilation for enclosed spaces. (a) Each enclosed space must be vented or ventilated. (b) There must be a means to close each vent...

  15. 46 CFR 181.310 - Fire main and hydrants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire main and hydrants. 181.310 Section 181.310 Shipping...) FIRE PROTECTION EQUIPMENT Fire Main System § 181.310 Fire main and hydrants. (a) A vessel that has a power driven fire pump must have a sufficient number of fire hydrants to reach any part of the...

  16. 46 CFR 181.500 - Required number, type, and location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Required number, type, and location. 181.500 Section 181... 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Portable Fire Extinguishers § 181.500 Required number, type, and location. (a) Each portable fire extinguisher on a vessel must be of an approved type. The...

  17. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Defense Commissioner. 0.181 Section 0.181..., Defense and Emergency Preparedness Functions § 0.181 The Defense Commissioner. The Defense Commissioner is designated by the Commission. The Defense Commissioner directs the homeland security, national security...

  18. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Defense Commissioner. 0.181 Section 0.181..., Defense and Emergency Preparedness Functions § 0.181 The Defense Commissioner. The Defense Commissioner is designated by the Commission. The Defense Commissioner directs the homeland security, national security...

  19. 19 CFR 181.43 - Eligible goods subject to drawback.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Eligible goods subject to drawback. 181.43 Section 181.43 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT...-Deferral Programs § 181.43 Eligible goods subject to drawback. Except as otherwise provided in this...

  20. 19 CFR 181.49 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Retention of records. 181.49 Section 181.49 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... Programs § 181.49 Retention of records. All records required to be kept by the exporter,...

  1. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  2. 1 CFR 18.1 - Original and copies required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Original and copies required. 18.1 Section 18.1... PROCESSING OF DOCUMENTS PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.1 Original and copies... two duplicate originals or certified copies. 1 However, if the document is printed or processed...

  3. 49 CFR 192.181 - Distribution line valves.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Distribution line valves. 192.181 Section 192.181... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.181 Distribution line valves. (a) Each high-pressure distribution system must have valves spaced so as to reduce...

  4. 22 CFR 181.7 - Transmittal to the Congress.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Transmittal to the Congress. 181.7 Section 181.7 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.7 Transmittal to the Congress. (a) International agreements other than treaties shall be transmitted by...

  5. 50 CFR 18.1 - Purpose of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Purpose of regulations. 18.1 Section 18.1 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED... PLANTS (CONTINUED) MARINE MAMMALS Introduction § 18.1 Purpose of regulations. The regulations...

  6. 7 CFR 28.181 - Review of cotton classification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Review of cotton classification. 28.181 Section 28.181... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.181 Review of cotton classification. A review of any classification or comparison made pursuant to this...

  7. 7 CFR 28.181 - Review of cotton classification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Review of cotton classification. 28.181 Section 28.181... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.181 Review of cotton classification. A review of any classification or comparison made pursuant to this...

  8. 7 CFR 28.181 - Review of cotton classification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Review of cotton classification. 28.181 Section 28.181... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.181 Review of cotton classification. A review of any classification or comparison made pursuant to this...

  9. 7 CFR 28.181 - Review of cotton classification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Review of cotton classification. 28.181 Section 28.181... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.181 Review of cotton classification. A review of any classification or comparison made pursuant to this...

  10. 7 CFR 28.181 - Review of cotton classification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Review of cotton classification. 28.181 Section 28.181... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Classification for Foreign Growth Cotton § 28.181 Review of cotton classification. A review of any classification or comparison made pursuant to this...

  11. 33 CFR 181.1 - Purpose and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Purpose and applicability. 181.1 Section 181.1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS General § 181.1 Purpose and applicability. This part...

  12. 33 CFR 181.4 - Incorporation by reference.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Incorporation by reference. 181.4 Section 181.4 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS General § 181.4 Incorporation by reference. (a) Certain...

  13. 33 CFR 181.1 - Purpose and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Purpose and applicability. 181.1 Section 181.1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS General § 181.1 Purpose and applicability. This part...

  14. 33 CFR 181.4 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Incorporation by reference. 181.4 Section 181.4 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS General § 181.4 Incorporation by reference. (a) Certain...

  15. 19 CFR 181.82 - Exceptions to application of penalties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Exceptions to application of penalties. 181.82 Section 181.82 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Penalties § 181.82 Exceptions...

  16. 19 CFR 181.82 - Exceptions to application of penalties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Exceptions to application of penalties. 181.82 Section 181.82 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Penalties § 181.82 Exceptions...

  17. 19 CFR 181.95 - Oral discussion of issues.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Oral discussion of issues. 181.95 Section 181.95 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.95 Oral...

  18. 19 CFR 181.101 - Publication of decisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Publication of decisions. 181.101 Section 181.101 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.101 Publication...

  19. 19 CFR 181.95 - Oral discussion of issues.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Oral discussion of issues. 181.95 Section 181.95 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.95 Oral...

  20. 19 CFR 181.95 - Oral discussion of issues.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Oral discussion of issues. 181.95 Section 181.95 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.95 Oral...

  1. 19 CFR 181.101 - Publication of decisions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Publication of decisions. 181.101 Section 181.101 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.101 Publication...

  2. 19 CFR 181.82 - Exceptions to application of penalties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Exceptions to application of penalties. 181.82 Section 181.82 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Penalties § 181.82 Exceptions...

  3. 19 CFR 181.82 - Exceptions to application of penalties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Exceptions to application of penalties. 181.82 Section 181.82 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Penalties § 181.82 Exceptions...

  4. 19 CFR 181.101 - Publication of decisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Publication of decisions. 181.101 Section 181.101 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.101 Publication...

  5. 19 CFR 181.101 - Publication of decisions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Publication of decisions. 181.101 Section 181.101 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.101 Publication...

  6. 19 CFR 181.95 - Oral discussion of issues.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Oral discussion of issues. 181.95 Section 181.95 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.95 Oral...

  7. 19 CFR 122.181 - Definition of Customs security area.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Definition of Customs security area. 122.181 Section 122.181 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Access to Customs Security Areas § 122.181 Definition...

  8. 19 CFR 181.114 - Customs response to request.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Customs response to request. 181.114 Section 181.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... Decisions § 181.114 Customs response to request. (a) Time for response. The port director will issue...

  9. 49 CFR 173.181 - Pyrophoric materials (liquids).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Pyrophoric materials (liquids). 173.181 Section 173.181 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Class 7 § 173.181 Pyrophoric materials (liquids). When the § 172.101 table specifies that a...

  10. 49 CFR 173.181 - Pyrophoric materials (liquids).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Pyrophoric materials (liquids). 173.181 Section 173.181 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Class 7 § 173.181 Pyrophoric materials (liquids). When the § 172.101 table specifies that a...

  11. 19 CFR 181.101 - Publication of decisions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Publication of decisions. 181.101 Section 181.101 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures § 181.101 Publication...

  12. 21 CFR 820.181 - Device master record.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Device master record. 820.181 Section 820.181 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES QUALITY SYSTEM REGULATION Records § 820.181 Device master record. Each manufacturer shall...

  13. 31 CFR 18.1 - Designation of First Assistants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Designation of First Assistants. 18.1 Section 18.1 Money and Finance: Treasury Office of the Secretary of the Treasury OFFICIALS DESIGNATED TO PERFORM THE FUNCTIONS AND DUTIES OF CERTAIN OFFICES IN CASE OF ABSENCE, DISABILITY, OR VACANCY § 18.1 Designation of First Assistants. Except...

  14. 14 CFR 29.181 - Dynamic stability: Category A rotorcraft.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Dynamic stability: Category A rotorcraft. 29.181 Section 29.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....181 Dynamic stability: Category A rotorcraft. Any short-period oscillation occurring at any speed...

  15. 14 CFR 29.181 - Dynamic stability: Category A rotorcraft.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Dynamic stability: Category A rotorcraft. 29.181 Section 29.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....181 Dynamic stability: Category A rotorcraft. Any short-period oscillation occurring at any speed...

  16. 14 CFR 29.181 - Dynamic stability: Category A rotorcraft.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Dynamic stability: Category A rotorcraft. 29.181 Section 29.181 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....181 Dynamic stability: Category A rotorcraft. Any short-period oscillation occurring at any speed...

  17. 46 CFR 108.181 - Ventilation for enclosed spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Ventilation for enclosed spaces. 108.181 Section 108.181... AND EQUIPMENT Construction and Arrangement Ventilation § 108.181 Ventilation for enclosed spaces. (a) Each enclosed space must be vented or ventilated. (b) There must be a means to close each vent...

  18. 46 CFR 108.181 - Ventilation for enclosed spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Ventilation for enclosed spaces. 108.181 Section 108.181... AND EQUIPMENT Construction and Arrangement Ventilation § 108.181 Ventilation for enclosed spaces. (a) Each enclosed space must be vented or ventilated. (b) There must be a means to close each vent...

  19. MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar.

    PubMed

    Kwan, Peter; Ding, Jie; Tredget, Edward E

    2015-01-01

    Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated in hypertrophic scar and normal deep dermal fibroblasts. It was hypothesized that microRNAs in these fibroblasts downregulate decorin and blocking them would increase decorin and may prevent hypertrophic scarring. Lower decorin levels were found in hypertrophic scar as compared to normal skin, and in deep as compared to superficial dermis. A decorin 3' un-translated region reporter assay demonstrated microRNA decreased decorin in deep dermal fibroblasts, and microRNA screening predicted miR- 24, 181b, 421, 526b, or 543 as candidates. After finding increased levels of mir-181b in deep dermal fibroblasts, it was demonstrated that TGF-β1 stimulation decreased miR-24 but increased miR-181b and that hypertrophic scar and deep dermis contained increased levels of miR-181b. By blocking miR-181b with an antagomiR, it was possible to increase decorin protein expression in dermal fibroblasts. This suggests miR-181b is involved in the differential expression of decorin in skin and wound healing. Furthermore, blocking miR-181b reversed TGF-β1 induced decorin downregulation and myofibroblast differentiation in hypertrophic scar fibroblasts, suggesting a potential therapy for hypertrophic scar.

  20. hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells.

    PubMed

    Shi, Lei; Cheng, Zihao; Zhang, Junxia; Li, Rui; Zhao, Peng; Fu, Zhen; You, Yongping

    2008-10-21

    MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by cleaving or repressing the translation of target mRNAs. In mammal animals, their function mainly represses the target mRNAs transcripts via imperfectly complementary to the 3' UTR of target mRNAs. Several miRNAs have been recently reported to be involved in modulation of glioma development, especially some up-regulated miRNA, such as hsa-miR-21 and hsa-miR-221. However, here we reported that the down-regulated hsa-miR-181a and hsa-miR-181b of hsa-miR-181 family were also involved in oncogenesis of glioma. Our studies showed that hsa-miR-181a and hsa-miR-181b functioned as tumor suppressors which triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. Furthermore, the tumor-suppressive effect of hsa-miR-181b in glioma cells was more apparent than the effect of hsa-miR-181a. These findings suggest aberrantly down-regulated hsa-miR-181a and hsa-miR-181b may be critical factors that contribute to malignant appearance in human gliomas.

  1. TGF-β Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth

    PubMed Central

    Carrella, Sabrina; Salierno, Francesco Giuseppe; Manfredi, Anna; Banfi, Sandro; Conte, Ivan

    2015-01-01

    Retinal axon specification and growth are critically sensitive to the dosage of numerous signaling molecules and transcription factors. Subtle variations in the expression levels of key molecules may result in a variety of axonal growth anomalies. miR-181a and miR-181b are two eye-enriched microRNAs whose inactivation in medaka fish leads to alterations of the proper establishment of connectivity and function in the visual system. miR-181a/b are fundamental regulators of MAPK signaling and their role in retinal axon growth and specification is just beginning to be elucidated. Here we demonstrate that miR-181a/b are key nodes in the interplay between TGF-β and MAPK/ERK within the functional pathways that control retinal axon specification and growth. Using a variety of in vivo and in vitro approaches in medaka fish, we demonstrate that TGF-β signaling controls the miR-181/ERK regulatory network, which in turn strengthens the TGF-β-mediated regulation of RhoA degradation. Significantly, these data uncover the role of TGF-β signaling in vivo, for the first time, in defining the correct wiring and assembly of functional retina neural circuits and further highlight miR-181a/b as key factors in axon specification and growth. PMID:26641497

  2. 21 CFR 145.181 - Artificially sweetened canned pineapple.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Artificially sweetened canned pineapple. 145.181... § 145.181 Artificially sweetened canned pineapple. (a) Artificially sweetened canned pineapple is the food that conforms to the definition and standard of identity prescribed for canned pineapple by §...

  3. 21 CFR 145.181 - Artificially sweetened canned pineapple.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Artificially sweetened canned pineapple. 145.181... § 145.181 Artificially sweetened canned pineapple. (a) Artificially sweetened canned pineapple is the food that conforms to the definition and standard of identity prescribed for canned pineapple by §...

  4. 21 CFR 145.181 - Artificially sweetened canned pineapple.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Artificially sweetened canned pineapple. 145.181... § 145.181 Artificially sweetened canned pineapple. (a) Artificially sweetened canned pineapple is the food that conforms to the definition and standard of identity prescribed for canned pineapple by §...

  5. 21 CFR 145.181 - Artificially sweetened canned pineapple.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened canned pineapple. 145.181... § 145.181 Artificially sweetened canned pineapple. (a) Artificially sweetened canned pineapple is the food that conforms to the definition and standard of identity prescribed for canned pineapple by §...

  6. 21 CFR 145.181 - Artificially sweetened canned pineapple.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Artificially sweetened canned pineapple. 145.181... § 145.181 Artificially sweetened canned pineapple. (a) Artificially sweetened canned pineapple is the food that conforms to the definition and standard of identity prescribed for canned pineapple by §...

  7. 19 CFR 10.181-10.182 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false 10.181-10.182 Section 10.181-10.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Watches and Watch...

  8. 19 CFR 10.181-10.182 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false 10.181-10.182 Section 10.181-10.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Watches and Watch...

  9. 19 CFR 10.181-10.182 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false 10.181-10.182 Section 10.181-10.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Watches and Watch...

  10. 19 CFR 10.181-10.182 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false 10.181-10.182 Section 10.181-10.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Watches and Watch...

  11. 19 CFR 10.181-10.182 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false 10.181-10.182 Section 10.181-10.182 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Watches and Watch...

  12. 21 CFR 181.34 - Sodium nitrite and potassium nitrite.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Sodium nitrite and potassium nitrite. 181.34...-Sanctioned Food Ingredients § 181.34 Sodium nitrite and potassium nitrite. Sodium nitrite and potassium... fixatives and preservative agents, with or without sodium or potassium nitrate, in the curing of red...

  13. 21 CFR 181.34 - Sodium nitrite and potassium nitrite.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Sodium nitrite and potassium nitrite. 181.34...-Sanctioned Food Ingredients § 181.34 Sodium nitrite and potassium nitrite. Sodium nitrite and potassium... fixatives and preservative agents, with or without sodium or potassium nitrate, in the curing of red...

  14. 21 CFR 181.34 - Sodium nitrite and potassium nitrite.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Sodium nitrite and potassium nitrite. 181.34...-Sanctioned Food Ingredients § 181.34 Sodium nitrite and potassium nitrite. Sodium nitrite and potassium... fixatives and preservative agents, with or without sodium or potassium nitrate, in the curing of red...

  15. 21 CFR 181.34 - Sodium nitrite and potassium nitrite.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Sodium nitrite and potassium nitrite. 181.34...-Sanctioned Food Ingredients § 181.34 Sodium nitrite and potassium nitrite. Sodium nitrite and potassium... fixatives and preservative agents, with or without sodium or potassium nitrate, in the curing of red...

  16. 19 CFR 181.81 - Applicability to NAFTA transactions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Applicability to NAFTA transactions. 181.81... to NAFTA transactions. Except as otherwise provided in § 181.82 of this part, all criminal, civil or... violations of the laws and regulations relating to the NAFTA....

  17. 19 CFR 181.81 - Applicability to NAFTA transactions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Applicability to NAFTA transactions. 181.81... to NAFTA transactions. Except as otherwise provided in § 181.82 of this part, all criminal, civil or... violations of the laws and regulations relating to the NAFTA....

  18. 19 CFR 181.81 - Applicability to NAFTA transactions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Applicability to NAFTA transactions. 181.81... to NAFTA transactions. Except as otherwise provided in § 181.82 of this part, all criminal, civil or... violations of the laws and regulations relating to the NAFTA....

  19. 19 CFR 181.81 - Applicability to NAFTA transactions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Applicability to NAFTA transactions. 181.81... to NAFTA transactions. Except as otherwise provided in § 181.82 of this part, all criminal, civil or... violations of the laws and regulations relating to the NAFTA....

  20. 19 CFR 181.81 - Applicability to NAFTA transactions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Applicability to NAFTA transactions. 181.81... to NAFTA transactions. Except as otherwise provided in § 181.82 of this part, all criminal, civil or... violations of the laws and regulations relating to the NAFTA....

  1. 21 CFR 169.181 - Vanilla-vanillin flavoring.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Vanilla-vanillin flavoring. 169.181 Section 169... Dressings and Flavorings § 169.181 Vanilla-vanillin flavoring. (a) Vanilla-vanillin flavoring conforms to... ingredients prescribed for vanilla-vanillin extract by § 169.180, except that its content of ethyl alcohol...

  2. 21 CFR 169.181 - Vanilla-vanillin flavoring.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Vanilla-vanillin flavoring. 169.181 Section 169... Dressings and Flavorings § 169.181 Vanilla-vanillin flavoring. (a) Vanilla-vanillin flavoring conforms to... ingredients prescribed for vanilla-vanillin extract by § 169.180, except that its content of ethyl alcohol...

  3. 33 CFR 181.703 - Information pamphlet: Contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Information pamphlet: Contents. 181.703 Section 181.703 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Instruction Pamphlet for Personal Flotation...

  4. 33 CFR 181.703 - Information pamphlet: Contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Information pamphlet: Contents. 181.703 Section 181.703 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Instruction Pamphlet for Personal Flotation...

  5. 19 CFR 181.47 - Completion of claim for drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Completion of claim for drawback. 181.47 Section 181.47 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... advertising brochure from the supplier, the basis for which the order was placed, and copy of a letter...

  6. 27 CFR 41.181 - Records of large cigars.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Records of large cigars. 41.181 Section 41.181 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND...

  7. 14 CFR 125.181 - Induction system ice prevention.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Induction system ice prevention. 125.181... Requirements § 125.181 Induction system ice prevention. A means for preventing the malfunctioning of each engine due to ice accumulation in the engine air induction system must be provided for each airplane....

  8. 14 CFR 125.181 - Induction system ice prevention.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Induction system ice prevention. 125.181... Requirements § 125.181 Induction system ice prevention. A means for preventing the malfunctioning of each engine due to ice accumulation in the engine air induction system must be provided for each airplane....

  9. 19 CFR 181.13 - Failure to comply with requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Failure to comply with requirements. 181.13 Section 181.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Export Requirements §...

  10. 19 CFR 181.122 - Disclosure to government authorities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  11. 19 CFR 181.62 - Commercial samples of negligible value.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Commercial samples of negligible value. 181.62 Section 181.62 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Commercial Samples and...

  12. 19 CFR 181.75 - Issuance of origin determination.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Issuance of origin determination. 181.75 Section 181.75 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications...

  13. 19 CFR 181.121 - Maintenance of confidentiality.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Maintenance of confidentiality. 181.121 Section 181.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  14. 19 CFR 181.75 - Issuance of origin determination.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Issuance of origin determination. 181.75 Section 181.75 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications...

  15. 19 CFR 181.13 - Failure to comply with requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Failure to comply with requirements. 181.13 Section 181.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Export Requirements §...

  16. 19 CFR 181.13 - Failure to comply with requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Failure to comply with requirements. 181.13 Section 181.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Export Requirements §...

  17. 19 CFR 181.75 - Issuance of origin determination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Issuance of origin determination. 181.75 Section 181.75 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications...

  18. 19 CFR 181.94 - Nonconforming requests for advance rulings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Nonconforming requests for advance rulings. 181.94 Section 181.94 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures §...

  19. 19 CFR 181.122 - Disclosure to government authorities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  20. 19 CFR 181.49 - Retention of records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Retention of records. 181.49 Section 181.49 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  1. 19 CFR 181.75 - Issuance of origin determination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Issuance of origin determination. 181.75 Section 181.75 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications...

  2. 19 CFR 181.121 - Maintenance of confidentiality.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Maintenance of confidentiality. 181.121 Section 181.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  3. 19 CFR 181.43 - Eligible goods subject to drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Eligible goods subject to drawback. 181.43 Section 181.43 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  4. 19 CFR 181.49 - Retention of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Retention of records. 181.49 Section 181.49 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  5. 19 CFR 181.121 - Maintenance of confidentiality.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Maintenance of confidentiality. 181.121 Section 181.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  6. 19 CFR 181.122 - Disclosure to government authorities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  7. 19 CFR 181.121 - Maintenance of confidentiality.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Maintenance of confidentiality. 181.121 Section 181.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  8. 19 CFR 181.13 - Failure to comply with requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Failure to comply with requirements. 181.13 Section 181.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Export Requirements §...

  9. 19 CFR 181.122 - Disclosure to government authorities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Disclosure to government authorities. 181.122 Section 181.122 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Confidentiality of...

  10. 19 CFR 181.94 - Nonconforming requests for advance rulings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Nonconforming requests for advance rulings. 181.94 Section 181.94 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures §...

  11. 19 CFR 181.62 - Commercial samples of negligible value.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Commercial samples of negligible value. 181.62 Section 181.62 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Commercial Samples and...

  12. 19 CFR 181.94 - Nonconforming requests for advance rulings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Nonconforming requests for advance rulings. 181.94 Section 181.94 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures §...

  13. 19 CFR 181.94 - Nonconforming requests for advance rulings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Nonconforming requests for advance rulings. 181.94 Section 181.94 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Advance Ruling Procedures §...

  14. 19 CFR 181.43 - Eligible goods subject to drawback.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Eligible goods subject to drawback. 181.43 Section 181.43 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  15. 21 CFR 169.181 - Vanilla-vanillin flavoring.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Vanilla-vanillin flavoring. 169.181 Section 169... Dressings and Flavorings § 169.181 Vanilla-vanillin flavoring. (a) Vanilla-vanillin flavoring conforms to... ingredients prescribed for vanilla-vanillin extract by § 169.180, except that its content of ethyl alcohol...

  16. 21 CFR 169.181 - Vanilla-vanillin flavoring.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Vanilla-vanillin flavoring. 169.181 Section 169... Dressings and Flavorings § 169.181 Vanilla-vanillin flavoring. (a) Vanilla-vanillin flavoring conforms to... ingredients prescribed for vanilla-vanillin extract by § 169.180, except that its content of ethyl alcohol...

  17. 21 CFR 169.181 - Vanilla-vanillin flavoring.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Vanilla-vanillin flavoring. 169.181 Section 169... Dressings and Flavorings § 169.181 Vanilla-vanillin flavoring. (a) Vanilla-vanillin flavoring conforms to... ingredients prescribed for vanilla-vanillin extract by § 169.180, except that its content of ethyl alcohol...

  18. 19 CFR 181.33 - Customs processing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Customs processing procedures. 181.33 Section 181.33 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF....33 Customs processing procedures. (a) Status determination. After receipt of a post-importation...

  19. 26 CFR 1.181-6T - Effective date (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... first day of principal photography for which occurs on or after February 9, 2007, and before January 1...-between animation” in place of “principal photography”. Productions involving both animation and live-action photography may use either standard. (2) The applicability of §§ 1.181-1T through 1.181-5T...

  20. 49 CFR 173.181 - Pyrophoric materials (liquids).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Pyrophoric materials (liquids). 173.181 Section... Class 7 § 173.181 Pyrophoric materials (liquids). When the § 172.101 table specifies that a hazardous... pyrophoric liquids may not exceed two-thirds of the rated capacity of the outer drum. For example, a 220...

  1. 49 CFR 173.181 - Pyrophoric materials (liquids).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Pyrophoric materials (liquids). 173.181 Section... Class 7 § 173.181 Pyrophoric materials (liquids). When the § 172.101 table specifies that a hazardous... pyrophoric liquids may not exceed two-thirds of the rated capacity of the outer drum. For example, a 220...

  2. 9 CFR 319.181 - Cheesefurters and similar products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Cheesefurters and similar products. 319.181 Section 319.181 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND...

  3. 27 CFR 70.181 - Disposition of seized property.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Disposition of seized property. 70.181 Section 70.181 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES PROCEDURE AND ADMINISTRATION Collection of Excise and Special...

  4. 19 CFR 181.11 - Certificate of Origin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certificate of Origin. 181.11 Section 181.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... such other medium or format as approved by the Canadian or Mexican customs administration for...

  5. 19 CFR 181.115 - Intervention in importer's protest.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Intervention in importer's protest. 181.115 Section 181.115 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... employer number assigned by Revenue Canada, Customs and Excise; in the case of a Mexican exporter...

  6. 19 CFR 181.12 - Maintenance and availability of records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 181.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... chapter in the case of U.S. importer records. (2) To the Canadian or Mexican customs administration. If a... the Canadian or Mexican customs administration under Article 506 of the NAFTA (see § 181.74(e) of...

  7. 19 CFR 181.12 - Maintenance and availability of records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 181.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... chapter in the case of U.S. importer records. (2) To the Canadian or Mexican customs administration. If a... the Canadian or Mexican customs administration under Article 506 of the NAFTA (see § 181.74(e) of...

  8. 19 CFR 181.48 - Person entitled to receive drawback.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Person entitled to receive drawback. 181.48 Section 181.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY..., Canadian or Mexican customs manifest, cargo manifest, or certified copies of these documents, shall...

  9. 19 CFR 181.48 - Person entitled to receive drawback.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Person entitled to receive drawback. 181.48 Section 181.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY..., Canadian or Mexican customs manifest, cargo manifest, or certified copies of these documents, shall...

  10. 19 CFR 181.48 - Person entitled to receive drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Person entitled to receive drawback. 181.48 Section 181.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY..., Canadian or Mexican customs manifest, cargo manifest, or certified copies of these documents, shall...

  11. 19 CFR 181.12 - Maintenance and availability of records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Section 181.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... chapter in the case of U.S. importer records. (2) To the Canadian or Mexican customs administration. If a... the Canadian or Mexican customs administration under Article 506 of the NAFTA (see § 181.74(e) of...

  12. 19 CFR 181.11 - Certificate of Origin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Certificate of Origin. 181.11 Section 181.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... such other medium or format as approved by the Canadian or Mexican customs administration for...

  13. 19 CFR 181.11 - Certificate of Origin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Certificate of Origin. 181.11 Section 181.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... such other medium or format as approved by the Canadian or Mexican customs administration for...

  14. 19 CFR 181.48 - Person entitled to receive drawback.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Person entitled to receive drawback. 181.48 Section 181.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY..., Canadian or Mexican customs manifest, cargo manifest, or certified copies of these documents, shall...

  15. 19 CFR 181.12 - Maintenance and availability of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 181.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... chapter in the case of U.S. importer records. (2) To the Canadian or Mexican customs administration. If a... the Canadian or Mexican customs administration under Article 506 of the NAFTA (see § 181.74(e) of...

  16. 19 CFR 181.11 - Certificate of Origin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Certificate of Origin. 181.11 Section 181.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... such other medium or format as approved by the Canadian or Mexican customs administration for...

  17. 19 CFR 181.48 - Person entitled to receive drawback.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Person entitled to receive drawback. 181.48 Section 181.48 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY..., Canadian or Mexican customs manifest, cargo manifest, or certified copies of these documents, shall...

  18. 19 CFR 181.115 - Intervention in importer's protest.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Intervention in importer's protest. 181.115 Section 181.115 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... employer number assigned by Revenue Canada, Customs and Excise; in the case of a Mexican exporter...

  19. 19 CFR 181.12 - Maintenance and availability of records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 181.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... chapter in the case of U.S. importer records. (2) To the Canadian or Mexican customs administration. If a... the Canadian or Mexican customs administration under Article 506 of the NAFTA (see § 181.74(e) of...

  20. 21 CFR 181.32 - Acrylonitrile copolymers and resins.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Acrylonitrile copolymers and resins. 181.32 Section 181.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... acrylonitrile monomer extraction for finished food-contact articles, determined by using the method of...

  1. 21 CFR 181.32 - Acrylonitrile copolymers and resins.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Acrylonitrile copolymers and resins. 181.32 Section 181.32 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... acrylonitrile monomer extraction for finished food-contact articles, determined by using the method of...

  2. 27 CFR 24.181 - Use of sugar.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Use of sugar. 24.181... OF THE TREASURY LIQUORS WINE Production of Wine § 24.181 Use of sugar. Only sugar, as defined in § 24.10, may be used in the production of standard wine. The quantity of sugar used will be...

  3. 27 CFR 24.181 - Use of sugar.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Use of sugar. 24.181... OF THE TREASURY LIQUORS WINE Production of Wine § 24.181 Use of sugar. Only sugar, as defined in § 24.10, may be used in the production of standard wine. The quantity of sugar used will be...

  4. 27 CFR 24.181 - Use of sugar.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Use of sugar. 24.181... OF THE TREASURY ALCOHOL WINE Production of Wine § 24.181 Use of sugar. Only sugar, as defined in § 24.10, may be used in the production of standard wine. The quantity of sugar used will be...

  5. 27 CFR 24.181 - Use of sugar.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Use of sugar. 24.181... OF THE TREASURY ALCOHOL WINE Production of Wine § 24.181 Use of sugar. Only sugar, as defined in § 24.10, may be used in the production of standard wine. The quantity of sugar used will be...

  6. 27 CFR 24.181 - Use of sugar.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Use of sugar. 24.181... OF THE TREASURY LIQUORS WINE Production of Wine § 24.181 Use of sugar. Only sugar, as defined in § 24.10, may be used in the production of standard wine. The quantity of sugar used will be...

  7. 46 CFR 181.115 - Applicability; preemptive effect.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Applicability; preemptive effect. 181.115 Section 181... effect. (a) Except as otherwise required by paragraphs (b) and (c) of this section, an existing vessel... regulations in this part. (d) The regulations in this part have preemptive effect over State or...

  8. 46 CFR 181.115 - Applicability; preemptive effect.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Applicability; preemptive effect. 181.115 Section 181... effect. (a) Except as otherwise required by paragraphs (b) and (c) of this section, an existing vessel... regulations in this part. (d) The regulations in this part have preemptive effect over State or...

  9. 26 CFR 1.181-6 - Effective/applicability date.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....181-1 through 1.181-5 apply to productions the first day of principal photography for which occurs on... principal photography or in-between animation occurs on or after December 7, 2012. (b) Pre-effective date... applies and for which the first day of principal photography (or in-between animation) occurred...

  10. 26 CFR 1.181-6 - Effective/applicability date.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....181-1 through 1.181-5 apply to productions the first day of principal photography for which occurs on... principal photography or in-between animation occurs on or after December 7, 2012. (b) Pre-effective date... applies and for which the first day of principal photography (or in-between animation) occurred...

  11. 26 CFR 1.181-6T - Effective date (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... first day of principal photography for which occurs on or after February 9, 2007, and before January 1...-between animation” in place of “principal photography”. Productions involving both animation and live-action photography may use either standard. (2) The applicability of §§ 1.181-1T through 1.181-5T...

  12. 27 CFR 9.181 - McMinnville.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false McMinnville. 9.181 Section... THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.181 McMinnville. (a) Name. The name of the viticultural area described in this section is “McMinnville.”...

  13. 21 CFR 181.33 - Sodium nitrate and potassium nitrate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Sodium nitrate and potassium nitrate. 181.33...-Sanctioned Food Ingredients § 181.33 Sodium nitrate and potassium nitrate. Sodium nitrate and potassium nitrate are subject to prior sanctions issued by the U.S. Department of Agriculture for use as sources...

  14. 21 CFR 181.33 - Sodium nitrate and potassium nitrate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Sodium nitrate and potassium nitrate. 181.33...-Sanctioned Food Ingredients § 181.33 Sodium nitrate and potassium nitrate. Sodium nitrate and potassium nitrate are subject to prior sanctions issued by the U.S. Department of Agriculture for use as sources...

  15. 21 CFR 181.33 - Sodium nitrate and potassium nitrate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Sodium nitrate and potassium nitrate. 181.33 Section 181.33 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... nitrate and potassium nitrate. Sodium nitrate and potassium nitrate are subject to prior sanctions...

  16. 21 CFR 181.33 - Sodium nitrate and potassium nitrate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Sodium nitrate and potassium nitrate. 181.33...-Sanctioned Food Ingredients § 181.33 Sodium nitrate and potassium nitrate. Sodium nitrate and potassium nitrate are subject to prior sanctions issued by the U.S. Department of Agriculture for use as sources...

  17. 21 CFR 181.33 - Sodium nitrate and potassium nitrate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Sodium nitrate and potassium nitrate. 181.33...-Sanctioned Food Ingredients § 181.33 Sodium nitrate and potassium nitrate. Sodium nitrate and potassium nitrate are subject to prior sanctions issued by the U.S. Department of Agriculture for use as sources...

  18. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  19. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  20. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  1. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  2. 29 CFR 1915.181 - Electrical circuits and distribution boards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Electrical circuits and distribution boards. 1915.181... Electrical Machinery § 1915.181 Electrical circuits and distribution boards. (a) The provisions of this... employee is permitted to work on an electrical circuit, except when the circuit must remain energized...

  3. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Hull identification number display. 181.29 Section 181.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... identification number display. Two identical hull identification numbers are required to be displayed on...

  4. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Hull identification number display. 181.29 Section 181.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... identification number display. Two identical hull identification numbers are required to be displayed on...

  5. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Hull identification number display. 181.29 Section 181.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... identification number display. Two identical hull identification numbers are required to be displayed on...

  6. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Hull identification number display. 181.29 Section 181.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... identification number display. Two identical hull identification numbers are required to be displayed on...

  7. 22 CFR 181.9 - Internet Web site publication.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Internet Web site publication. 181.9 Section... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.9 Internet Web site publication. The Office of the Assistant... responsible for making publicly available on the Internet Web site of the Department of State each treaty...

  8. 22 CFR 181.9 - Internet Web site publication.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Internet Web site publication. 181.9 Section... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.9 Internet Web site publication. The Office of the Assistant... responsible for making publicly available on the Internet Web site of the Department of State each treaty...

  9. 22 CFR 181.9 - Internet Web site publication.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Internet Web site publication. 181.9 Section... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.9 Internet Web site publication. The Office of the Assistant... responsible for making publicly available on the Internet Web site of the Department of State each treaty...

  10. 22 CFR 181.9 - Internet Web site publication.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Internet Web site publication. 181.9 Section... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.9 Internet Web site publication. The Office of the Assistant... responsible for making publicly available on the Internet Web site of the Department of State each treaty...

  11. 22 CFR 181.9 - Internet Web site publication.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Internet Web site publication. 181.9 Section... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.9 Internet Web site publication. The Office of the Assistant... responsible for making publicly available on the Internet Web site of the Department of State each treaty...

  12. The DELTA 181 lithium thionyl chloride battery

    NASA Astrophysics Data System (ADS)

    Sullivan, Ralph M.; Brown, Lawrence E.; Leigh, A. P.

    In 1986, the Johns Hopkins University/Applied Physics Laboratory (JHU/APL) undertook the development of a sensor module for the DELTA 181 spacecraft, a low earth orbit (LEO) mission of less than two months duration. A large lithium thionyl chloride battery was developed as the spacecraft's primary power source, the first known such use for this technology. The exceptionally high energy density of the lithium thionyl chloride cell was the primary driver for its use, resulting in a completed battery with a specific energy density of 120 Wh/lb. Safety requirements became the primary driver shaping all aspects of the power system design and development due to concerns about the potential hazards of this relatively new, high-energy technology. However, the program was completed without incident. The spacecraft was launched on February 8, 1988, from Kennedy Space Center (KSC) with over 60,000 Wh of battery energy. It reentered on April 2, 1988, still operating after 55 days, providing a successful, practical, and visible demonstration of the use of this technology for spacecraft applications.

  13. 40 CFR 60.181 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lead bullion. (g) Electric smelting furnace means any furnace in which the heat necessary for smelting of the lead sulfide ore concentrate charge is generated by passing an electric current through...

  14. 40 CFR 60.181 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... lead bullion. (g) Electric smelting furnace means any furnace in which the heat necessary for smelting of the lead sulfide ore concentrate charge is generated by passing an electric current through...

  15. 40 CFR 60.181 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... lead bullion. (g) Electric smelting furnace means any furnace in which the heat necessary for smelting of the lead sulfide ore concentrate charge is generated by passing an electric current through...

  16. 40 CFR 60.181 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... lead bullion. (g) Electric smelting furnace means any furnace in which the heat necessary for smelting of the lead sulfide ore concentrate charge is generated by passing an electric current through...

  17. 40 CFR 60.181 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... lead bullion. (g) Electric smelting furnace means any furnace in which the heat necessary for smelting of the lead sulfide ore concentrate charge is generated by passing an electric current through...

  18. 14 CFR 29.181 - Dynamic stability: Category A rotorcraft.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Dynamic stability: Category A rotorcraft....181 Dynamic stability: Category A rotorcraft. Any short-period oscillation occurring at any speed from.... Ground and Water Handling Characteristics...

  19. 14 CFR 29.181 - Dynamic stability: Category A rotorcraft.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Dynamic stability: Category A rotorcraft....181 Dynamic stability: Category A rotorcraft. Any short-period oscillation occurring at any speed from.... Ground and Water Handling Characteristics...

  20. 33 CFR 181.702 - Information pamphlet: requirement to furnish.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Flotation Devices § 181.702 Information pamphlet: requirement to furnish. (a) Each manufacturer of a Type I, II, III, IV, or V personal flotation device (PFD) must furnish with each PFD that is sold or...

  1. 33 CFR 181.702 - Information pamphlet: requirement to furnish.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Flotation Devices § 181.702 Information pamphlet: requirement to furnish. (a) Each manufacturer of a Type I, II, III, IV, or V personal flotation device (PFD) must furnish with each PFD that is sold or...

  2. 19 CFR 181.33 - Customs processing procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Post-Importation Duty Refund Claims § 181... or dutiability of the good is filed in the Court of International Trade, the port director...

  3. 7 CFR 1260.181 - Qualified State beef councils.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... furnish the Board with an annual report by a certified public accountant of all funds remitted to such....181 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE...

  4. 50 CFR 18.1 - Purpose of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PLANTS (CONTINUED) MARINE MAMMALS Introduction § 18.1 Purpose of regulations. The regulations contained in this part implement the Marine Mammal Protection Act of 1972 (16 U.S.C. 1361-1407), which among... importing of marine mammals....

  5. 26 CFR 1.181-4 - Special rules.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... before computing gain or loss from the disposition. (2) Principal photography not commencing prior to the... for which principal photography does not commence prior to the date of expiration of section 181,...

  6. 26 CFR 1.181-4 - Special rules.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... before computing gain or loss from the disposition. (2) Principal photography not commencing prior to the... for which principal photography does not commence prior to the date of expiration of section 181,...

  7. 26 CFR 1.181-4 - Special rules.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... before computing gain or loss from the disposition. (2) Principal photography not commencing prior to the... for which principal photography does not commence prior to the date of expiration of section 181,...

  8. miR‐181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth

    PubMed Central

    Carrella, Sabrina; D'Agostino, Ylenia; Barbato, Sara; Huber‐Reggi, Sabina P.; Salierno, Francesco G.; Manfredi, Anna; Neuhauss, Stephan C.F.

    2015-01-01

    ABSTRACT Connectivity and function of neuronal circuitry require the correct specification and growth of axons and dendrites. Here, we identify the microRNAs miR‐181a and miR‐181b as key regulators of retinal axon specification and growth. Loss of miR‐181a/b in medaka fish (Oryzias latipes) failed to consolidate amacrine cell processes into axons and delayed the growth of retinal ganglion cell (RGC) axons. These alterations were accompanied by defects in visual connectivity and function. We demonstrated that miR‐181a/b exert these actions through negative modulation of MAPK/ERK signaling that in turn leads to RhoA reduction and proper neuritogenesis in both amacrine cells and RGCs via local cytoskeletal rearrangement. Our results identify a new pathway for axon specification and growth unraveling a crucial role of miR‐181a/b in the proper establishment of visual system connectivity and function. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1252–1267, 2015 PMID:25728313

  9. miR-181b negatively regulates activation-induced cytidine deaminase in B cells.

    PubMed

    de Yébenes, Virginia G; Belver, Laura; Pisano, David G; González, Susana; Villasante, Aranzazu; Croce, Carlo; He, Lin; Ramiro, Almudena R

    2008-09-29

    Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of chromosome translocations, suggesting that the fine tuning of AID expression may be critical to restrict B cell lymphomagenesis. To determine whether microRNAs (miRNAs) play a role in the regulation of AID expression, we performed a functional screening of an miRNA library and identified miRNAs that regulate CSR. One such miRNA, miR-181b, impairs CSR when expressed in activated B cells, and results in the down-regulation of AID mRNA and protein levels. We found that the AID 3' untranslated region contains multiple putative binding sequences for miR-181b and that these sequences can be directly targeted by miR-181b. Overall, our results provide evidence for a new regulatory mechanism that restricts AID activity and can therefore be relevant to prevent B cell malignant transformation.

  10. Complete sequence of the IncT-type plasmid pT-OXA-181 carrying the blaOXA-181 carbapenemase gene from Citrobacter freundii.

    PubMed

    Villa, Laura; Carattoli, Alessandra; Nordmann, Patrice; Carta, Claudio; Poirel, Laurent

    2013-04-01

    The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and blaOXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene.

  11. Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

    PubMed

    Schmitz, Sabine K; King, Cillian; Kortleven, Christian; Huson, Vincent; Kroon, Tim; Kevenaar, Josta T; Schut, Desiree; Saarloos, Ingrid; Hoetjes, Joost P; de Wit, Heidi; Stiedl, Oliver; Spijker, Sabine; Li, Ka Wan; Mansvelder, Huibert D; Smit, August B; Cornelisse, Lennart Niels; Verhage, Matthijs; Toonen, Ruud F

    2016-06-01

    Presynaptic cannabinoid (CB1R) and metabotropic glutamate receptors (mGluR2/3) regulate synaptic strength by inhibiting secretion. Here, we reveal a presynaptic inhibitory pathway activated by extracellular signal-regulated kinase (ERK) that mediates CB1R- and mGluR2/3-induced secretion inhibition. This pathway is triggered by a variety of events, from foot shock-induced stress to intense neuronal activity, and induces phosphorylation of the presynaptic protein Munc18-1. Mimicking constitutive phosphorylation of Munc18-1 results in a drastic decrease in synaptic transmission. ERK-mediated phosphorylation of Munc18-1 ultimately leads to degradation by the ubiquitin-proteasome system. Conversely, preventing ERK-dependent Munc18-1 phosphorylation increases synaptic strength. CB1R- and mGluR2/3-induced synaptic inhibition and depolarization-induced suppression of excitation (DSE) are reduced upon ERK/MEK pathway inhibition and further reduced when ERK-dependent Munc18-1 phosphorylation is blocked. Thus, ERK-dependent Munc18-1 phosphorylation provides a major negative feedback loop to control synaptic strength upon activation of presynaptic receptors and during intense neuronal activity.

  12. 33 CFR 181.15 - Contents of labels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SKILL REQUIRED MAY EXCEED THE ABILITIES OF SOME OPERATORS. ... labels. (a) Each label required by § 181.7 must contain: (1) The name and address of the manufacturer or... addition to the information required by paragraphs (a) and (b) of this section, display on...

  13. 21 CFR 181.34 - Sodium nitrite and potassium nitrite.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Sodium nitrite and potassium nitrite. 181.34... nitrite and potassium nitrite. Sodium nitrite and potassium nitrite are subject to prior sanctions issued... without sodium or potassium nitrate, in the curing of red meat and poultry products....

  14. 13 CFR 120.181 - Status of Lenders and CDCs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Status of Lenders and CDCs. 120....181 Status of Lenders and CDCs. Lenders, CDCs and their contractors are independent contractors that... wrongful action taken by a Lender, CDC or an employee, agent, or contractor of a Lender or CDC....

  15. 13 CFR 120.181 - Status of Lenders and CDCs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Status of Lenders and CDCs. 120....181 Status of Lenders and CDCs. Lenders, CDCs and their contractors are independent contractors that... wrongful action taken by a Lender, CDC or an employee, agent, or contractor of a Lender or CDC....

  16. 13 CFR 120.181 - Status of Lenders and CDCs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Status of Lenders and CDCs. 120....181 Status of Lenders and CDCs. Lenders, CDCs and their contractors are independent contractors that... wrongful action taken by a Lender, CDC or an employee, agent, or contractor of a Lender or CDC....

  17. 13 CFR 120.181 - Status of Lenders and CDCs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Status of Lenders and CDCs. 120....181 Status of Lenders and CDCs. Lenders, CDCs and their contractors are independent contractors that... wrongful action taken by a Lender, CDC or an employee, agent, or contractor of a Lender or CDC....

  18. 13 CFR 120.181 - Status of Lenders and CDCs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Status of Lenders and CDCs. 120....181 Status of Lenders and CDCs. Lenders, CDCs and their contractors are independent contractors that... wrongful action taken by a Lender, CDC or an employee, agent, or contractor of a Lender or CDC....

  19. 12 CFR 18.1 - Purpose and OMB control number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... statement with narrative information management deems important. The availability of this information is... AND OTHER INFORMATION BY NATIONAL BANKS § 18.1 Purpose and OMB control number. (a) Purpose. The... public confidence in the national banking system. (b) OMB control number. The collection of...

  20. 12 CFR 18.1 - Purpose and OMB control number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... statement with narrative information management deems important. The availability of this information is... AND OTHER INFORMATION BY NATIONAL BANKS § 18.1 Purpose and OMB control number. (a) Purpose. The... public confidence in the national banking system. (b) OMB control number. The collection of...

  1. 12 CFR 18.1 - Purpose and OMB control number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... statement with narrative information management deems important. The availability of this information is... AND OTHER INFORMATION BY NATIONAL BANKS § 18.1 Purpose and OMB control number. (a) Purpose. The... public confidence in the national banking system. (b) OMB control number. The collection of...

  2. 12 CFR 18.1 - Purpose and OMB control number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... statement with narrative information management deems important. The availability of this information is... AND OTHER INFORMATION BY NATIONAL BANKS § 18.1 Purpose and OMB control number. (a) Purpose. The... public confidence in the national banking system. (b) OMB control number. The collection of...

  3. 12 CFR 18.1 - Purpose and OMB control number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... statement with narrative information management deems important. The availability of this information is... AND OTHER INFORMATION BY NATIONAL BANKS § 18.1 Purpose and OMB control number. (a) Purpose. The... public confidence in the national banking system. (b) OMB control number. The collection of...

  4. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United...

  5. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United...

  6. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United...

  7. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United...

  8. 27 CFR 555.181 - Reporting of plastic explosives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Reporting of plastic..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Marking of Plastic Explosives § 555.181 Reporting of plastic explosives. All persons, other than an agency of the United...

  9. 19 CFR 181.73 - Notification of verification visit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... receipt, to the address of the Canadian or Mexican exporter or producer whose premises are to be visited... Canadian or Mexican exporter or producer of the good, or producer of the material, whose premises are to...

  10. 19 CFR 181.47 - Completion of claim for drawback.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 181.47 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... appropriate completed drawback entry form, evidence of exportation (a copy of the Canadian or Mexican customs... the Canadian or Mexican importer as to the amount of duties paid. Each drawback entry form filed...

  11. 19 CFR 181.76 - Application of origin determinations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 181.76 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Aduanera or the applicable provision of Mexican law related to advance rulings under Article 509 of the NAFTA; and (2) “Consistent treatment” means the established application by the Canadian or...

  12. 19 CFR 181.73 - Notification of verification visit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... receipt, to the address of the Canadian or Mexican exporter or producer whose premises are to be visited... Canadian or Mexican exporter or producer of the good, or producer of the material, whose premises are to...

  13. 19 CFR 181.76 - Application of origin determinations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 181.76 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Aduanera or the applicable provision of Mexican law related to advance rulings under Article 509 of the NAFTA; and (2) “Consistent treatment” means the established application by the Canadian or...

  14. 19 CFR 181.47 - Completion of claim for drawback.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 181.47 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... appropriate completed drawback entry form, evidence of exportation (a copy of the Canadian or Mexican customs... the Canadian or Mexican importer as to the amount of duties paid. Each drawback entry form filed...

  15. 19 CFR 181.73 - Notification of verification visit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... receipt, to the address of the Canadian or Mexican exporter or producer whose premises are to be visited... Canadian or Mexican exporter or producer of the good, or producer of the material, whose premises are to...

  16. 19 CFR 181.76 - Application of origin determinations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 181.76 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Aduanera or the applicable provision of Mexican law related to advance rulings under Article 509 of the NAFTA; and (2) “Consistent treatment” means the established application by the Canadian or...

  17. 19 CFR 181.45 - Goods eligible for full drawback.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 181.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Canadian or Mexican originating good that is dutiable and is imported into the United States is eligible... goods will continue to receive full drawback as they cross NAFTA borders for successive stages...

  18. 19 CFR 181.45 - Goods eligible for full drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 181.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Canadian or Mexican originating good that is dutiable and is imported into the United States is eligible... goods will continue to receive full drawback as they cross NAFTA borders for successive stages...

  19. 19 CFR 181.47 - Completion of claim for drawback.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 181.47 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... appropriate completed drawback entry form, evidence of exportation (a copy of the Canadian or Mexican customs... the Canadian or Mexican importer as to the amount of duties paid. Each drawback entry form filed...

  20. 19 CFR 181.45 - Goods eligible for full drawback.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 181.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Canadian or Mexican originating good that is dutiable and is imported into the United States is eligible... goods will continue to receive full drawback as they cross NAFTA borders for successive stages...

  1. 19 CFR 181.73 - Notification of verification visit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... receipt, to the address of the Canadian or Mexican exporter or producer whose premises are to be visited... Canadian or Mexican exporter or producer of the good, or producer of the material, whose premises are to...

  2. 19 CFR 181.45 - Goods eligible for full drawback.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 181.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Canadian or Mexican originating good that is dutiable and is imported into the United States is eligible... goods will continue to receive full drawback as they cross NAFTA borders for successive stages...

  3. 19 CFR 181.73 - Notification of verification visit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 181.73 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... receipt, to the address of the Canadian or Mexican exporter or producer whose premises are to be visited... Canadian or Mexican exporter or producer of the good, or producer of the material, whose premises are to...

  4. 18 CFR 367.1810 - Account 181, Unamortized debt expense.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GAS ACT Balance Sheet Chart of Accounts Deferred Debits § 367.1810 Account 181, Unamortized debt..., Unamortized debt expense. 367.1810 Section 367.1810 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF...

  5. 27 CFR 31.181 - Requirements for retail dealers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Requirements for retail... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS ALCOHOL BEVERAGE DEALERS Records and Reports Retail Dealer's Records § 31.181 Requirements for retail dealers. (a) Records of receipt. All retail dealers must keep...

  6. 19 CFR 181.93 - Submission of advance ruling requests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... English language and in the form of a letter. For any subject matter specified in § 181.92(b)(6)(i), (v... quasi-judicial body in Canada or Mexico; (2) A verification of origin performed in the United States, Canada or Mexico; (3) An administrative appeal in the United States, Canada or Mexico; or (4) A...

  7. 33 CFR 181.31 - Manufacturer identification code assignment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manufacturer identification code... SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.31 Manufacturer... request a manufacturer identification code in writing from the Recreational Boating Product...

  8. 26 CFR 1.181-5T - Examples (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...: Example 1. X, a corporation using a calendar taxable year, is a producer of films. X is the owner (within the meaning of § 1.181-1T(a)(2)) of film ABC. X incurs production costs in year 1, but does not commence principal photography for film ABC until year 2. In year 1, X reasonably expects, based on all...

  9. 46 CFR 181.450 - Independent modular smoke detecting units.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Independent modular smoke detecting units. 181.450... Independent modular smoke detecting units. (a) An independent modular smoke detecting unit must: (1) Meet UL 217 (incorporated by reference, see 46 CFR 175.600) and be listed as a “Single Station Smoke...

  10. 46 CFR 181.450 - Independent modular smoke detecting units.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Independent modular smoke detecting units. 181.450... Independent modular smoke detecting units. (a) An independent modular smoke detecting unit must: (1) Meet UL 217 (incorporated by reference, see 46 CFR 175.600) and be listed as a “Single Station Smoke...

  11. 46 CFR 181.450 - Independent modular smoke detecting units.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Independent modular smoke detecting units. 181.450... Independent modular smoke detecting units. (a) An independent modular smoke detecting unit must: (1) Meet UL 217 (incorporated by reference, see 46 CFR 175.600) and be listed as a “Single Station Smoke...

  12. 46 CFR 181.450 - Independent modular smoke detecting units.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Independent modular smoke detecting units. 181.450... Independent modular smoke detecting units. (a) An independent modular smoke detecting unit must: (1) Meet UL 217 (incorporated by reference, see 46 CFR 175.600) and be listed as a “Single Station Smoke...

  13. 46 CFR 181.450 - Independent modular smoke detecting units.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Independent modular smoke detecting units. 181.450... Independent modular smoke detecting units. (a) An independent modular smoke detecting unit must: (1) Meet UL 217 (incorporated by reference, see 46 CFR 175.600) and be listed as a “Single Station Smoke...

  14. Identification of Cellular Targets of MicroRNA-181a in HepG2 Cells: A New Approach for Functional Analysis of MicroRNAs

    PubMed Central

    Tan, Jane Yi Lin; Habib, Nagy A.; Chuah, York Wieo; Yau, Yin Hoe; Geifman-Shochat, Susana; Chen, Wei Ning

    2015-01-01

    MicroRNAs (miRNAs) are known to play a part in regulating important cellular processes. They generally perform their regulatory function through their binding with mRNAs, ultimately leading to a repression of target protein expression levels. However, their roles in cellular processes are poorly understood due to the limited understanding of their specific cellular targets. Aberrant levels of miRNAs have been found in hepatocellular carcinoma (HCC) including miR-181a. Using bioinformatics analysis, cyclin-dependent kinase inhibitor 1B (CDKN1β) and transcriptional factor E2F7 were identified as potential targets of miR-181a. Validation analysis using surface plasmon resonance (SPR) showed a positive binding between miR-181a and the 3’UTRs of these two potential mRNA targets. In vivo luciferase assay further confirmed the positive miR-181a:mRNA bindings, where a significant decrease in luciferase activity was detected when HepG2 cells were co-transfected with the 3’UTR-containing reporter plasmids and miR-181a. The potential impact of miR-181a binding to its specific targets on the general cellular behavior was further investigated. Results showed that miR-181a significantly activated the MAPK/JNK pathway which regulates cell proliferation, supporting our recently reported findings. Inhibition of miR-181a, on the other hand, abolished the observed activation. Our findings open up a new approach in designing targeted functional analysis of miRNAs in cellular processes, through the identification of their cellular targets. PMID:25901570

  15. Identification of Cellular Targets of MicroRNA-181a in HepG2 Cells: A New Approach for Functional Analysis of MicroRNAs.

    PubMed

    Tan, Jane Yi Lin; Habib, Nagy A; Chuah, York Wieo; Yau, Yin Hoe; Geifman-Shochat, Susana; Chen, Wei Ning

    2015-01-01

    MicroRNAs (miRNAs) are known to play a part in regulating important cellular processes. They generally perform their regulatory function through their binding with mRNAs, ultimately leading to a repression of target protein expression levels. However, their roles in cellular processes are poorly understood due to the limited understanding of their specific cellular targets. Aberrant levels of miRNAs have been found in hepatocellular carcinoma (HCC) including miR-181a. Using bioinformatics analysis, cyclin-dependent kinase inhibitor 1B (CDKN1β) and transcriptional factor E2F7 were identified as potential targets of miR-181a. Validation analysis using surface plasmon resonance (SPR) showed a positive binding between miR-181a and the 3'UTRs of these two potential mRNA targets. In vivo luciferase assay further confirmed the positive miR-181a:mRNA bindings, where a significant decrease in luciferase activity was detected when HepG2 cells were co-transfected with the 3'UTR-containing reporter plasmids and miR-181a. The potential impact of miR-181a binding to its specific targets on the general cellular behavior was further investigated. Results showed that miR-181a significantly activated the MAPK/JNK pathway which regulates cell proliferation, supporting our recently reported findings. Inhibition of miR-181a, on the other hand, abolished the observed activation. Our findings open up a new approach in designing targeted functional analysis of miRNAs in cellular processes, through the identification of their cellular targets.

  16. OXA-181-producing Klebsiella pneumoniae establishing in Singapore

    PubMed Central

    2013-01-01

    Background Carbapenemase producing Enterobacteriaceae are becoming a major public health concern globally, however, relatively little is known about the molecular and clinical epidemiology of these organisms in many parts of the world. Methods As part of a laboratory surveillance programme, 96 carbapenem non-susceptible Enterobacteriaceae isolates from clinical samples from patients in seven hospitals were referred for investigation for carbapenemases. Using polymerase chain reaction (PCR) to screen for a collection of genes encoding carbapenemases, 33 of 96 (34.5%) isolates were confirmed as carbapenemase producers. NDM-1 producers were the most prevalent at 64% (21/33) whilst OXA-181 was the second most common carbapenemase constituting 24.5% (8/33) of the carbapenemase producing isolates. Seven of these eight OXA-181 positive isolates underwent further characterisation with screening for other transmissible antimicrobial resistance determinants using PCR. Clonal relatedness was explored using Multilocus sequence typing (MLST) and Pulsed Field Gel Electrophoresis (PFGE). Plasmid characterisation was performed including restriction analysis and transfer by conjugation or transformation. Results In addition to the OXA-181 gene, all contained other transmissible resistance determinants including extended spectrum β-lactamases, oxacillinases or 16S rRNA methylase genes, but none contained metallo-β-lactamases or serine carbapenemases. All isolates had a multidrug resistant phenotype with two isolates being resistant to every antibiotic tested including colistin. Multilocus sequence typing confirmed five isolates belonged to ST17 and two to ST14, with those belonging to the same sequence type having identical PFGE profiles. The OXA-181 gene was typically carried on large plasmids which were mostly non-conjugative. Conclusions OXA-181 carbapenemase appears to be an important and probably under-recognised cause of carbapenem resistance in Enterobacteriaceae in

  17. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner

    PubMed Central

    Cijsouw, Tony; Weber, Jens P.; Broeke, Jurjen H.; Broek, Jantine A.C.; Schut, Desiree; Kroon, Tim; Saarloos, Ingrid

    2014-01-01

    Munc18-1 is a soluble protein essential for synaptic transmission. To investigate the dynamics of endogenous Munc18-1 in neurons, we created a mouse model expressing fluorescently tagged Munc18-1 from the endogenous munc18-1 locus. We show using fluorescence recovery after photobleaching in hippocampal neurons that the majority of Munc18-1 trafficked through axons and targeted to synapses via lateral diffusion together with syntaxin-1. Munc18-1 was strongly expressed at presynaptic terminals, with individual synapses showing a large variation in expression. Axon–synapse exchange rates of Munc18-1 were high: during stimulation, Munc18-1 rapidly dispersed from synapses and reclustered within minutes. Munc18-1 reclustering was independent of syntaxin-1, but required calcium influx and protein kinase C (PKC) activity. Importantly, a PKC-insensitive Munc18-1 mutant did not recluster. We show that synaptic Munc18-1 levels correlate with synaptic strength, and that synapses that recruit more Munc18-1 after stimulation have a larger releasable vesicle pool. Hence, PKC-dependent dynamic control of Munc18-1 levels enables individual synapses to tune their output during periods of activity. PMID:24590174

  18. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.

    PubMed

    Cijsouw, Tony; Weber, Jens P; Broeke, Jurjen H; Broek, Jantine A C; Schut, Desiree; Kroon, Tim; Saarloos, Ingrid; Verhage, Matthijs; Toonen, Ruud F

    2014-03-03

    Munc18-1 is a soluble protein essential for synaptic transmission. To investigate the dynamics of endogenous Munc18-1 in neurons, we created a mouse model expressing fluorescently tagged Munc18-1 from the endogenous munc18-1 locus. We show using fluorescence recovery after photobleaching in hippocampal neurons that the majority of Munc18-1 trafficked through axons and targeted to synapses via lateral diffusion together with syntaxin-1. Munc18-1 was strongly expressed at presynaptic terminals, with individual synapses showing a large variation in expression. Axon-synapse exchange rates of Munc18-1 were high: during stimulation, Munc18-1 rapidly dispersed from synapses and reclustered within minutes. Munc18-1 reclustering was independent of syntaxin-1, but required calcium influx and protein kinase C (PKC) activity. Importantly, a PKC-insensitive Munc18-1 mutant did not recluster. We show that synaptic Munc18-1 levels correlate with synaptic strength, and that synapses that recruit more Munc18-1 after stimulation have a larger releasable vesicle pool. Hence, PKC-dependent dynamic control of Munc18-1 levels enables individual synapses to tune their output during periods of activity.

  19. 142. North Carolina route 181 grade separation structure. This single ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    142. North Carolina route 181 grade separation structure. This single span, reinforced concrete, elliptical, spandrel arch structure, built in 1959, is on a slight skew as it passes over the parkway accounting for its wide span of 80. It is one of the few structures to pass over the parkway. This view of the elevation is to the north. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  20. 257. North Carolina Route 181 grade separation structure is a ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    257. North Carolina Route 181 grade separation structure is a single-span, reinforced concrete, elliptical spandrel arch structure built in 1959, it is on a slight skew as it passes over the parkway accounting for its wide span of 80. It is one of the few structures to pass over the parkway. This view is to the north. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  1. 19 CFR 181.42 - Duties and fees not subject to drawback.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Duties and fees not subject to drawback. 181.42 Section 181.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.42 Duties and fees not subject to drawback. The following duties or fees which...

  2. 19 CFR 181.50 - Liquidation and payment of drawback claims.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Liquidation and payment of drawback claims. 181.50 Section 181.50 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.50 Liquidation and payment of drawback claims. (a) General. When the drawback...

  3. 19 CFR 181.46 - Time and place for filing drawback claim.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Time and place for filing drawback claim. 181.46 Section 181.46 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.46 Time and place for filing drawback claim. (a) Time of filing. A drawback...

  4. 40 CFR 81.181 - Down East Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Down East Intrastate Air Quality Control Region. 81.181 Section 81.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.181 Down East Intrastate Air Quality Control Region. The Down East...

  5. 40 CFR 81.181 - Down East Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Down East Intrastate Air Quality Control Region. 81.181 Section 81.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.181 Down East Intrastate Air Quality Control Region. The Down East...

  6. 40 CFR 81.181 - Down East Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Down East Intrastate Air Quality Control Region. 81.181 Section 81.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.181 Down East Intrastate Air Quality Control Region. The Down East...

  7. 40 CFR 81.181 - Down East Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Down East Intrastate Air Quality Control Region. 81.181 Section 81.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.181 Down East Intrastate Air Quality Control Region. The Down East...

  8. 40 CFR 81.181 - Down East Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Down East Intrastate Air Quality Control Region. 81.181 Section 81.181 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.181 Down East Intrastate Air Quality Control Region. The Down East...

  9. 33 CFR 181.33 - Conditions for use of manufacturer identification codes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... manufacturer identification codes. 181.33 Section 181.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.33 Conditions for use of manufacturer identification codes. (a) No manufacturer or importer...

  10. 26 CFR 1.181-0T - Table of contents (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-1T through 1.181-6T. § 1.181-1T;Deduction for qualified film and television production costs.... (i) In general. (ii) Significantly incurred. (iii) Animated film and television productions. (iv..., 2006, and before March 12, 2007. (3) Information required. § 1.181-3TQualified film or...

  11. 33 CFR 181.704 - Contents of information pamphlet: Recreational hybrid PFD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...: Recreational hybrid PFD. 181.704 Section 181.704 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Flotation Devices § 181.704 Contents of information pamphlet: Recreational hybrid PFD. Each information pamphlet for a recreational hybrid PFD approved under 46 CFR 160.077 must contain the information...

  12. 33 CFR 181.704 - Contents of information pamphlet: Recreational hybrid PFD.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: Recreational hybrid PFD. 181.704 Section 181.704 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Flotation Devices § 181.704 Contents of information pamphlet: Recreational hybrid PFD. Each information pamphlet for a recreational hybrid PFD approved under 46 CFR 160.077 must contain the information...

  13. 33 CFR 181.704 - Contents of information pamphlet: Recreational hybrid PFD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...: Recreational hybrid PFD. 181.704 Section 181.704 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Flotation Devices § 181.704 Contents of information pamphlet: Recreational hybrid PFD. Each information pamphlet for a recreational hybrid PFD approved under 46 CFR 160.077 must contain the information...

  14. 33 CFR 181.704 - Contents of information pamphlet: Recreational hybrid PFD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...: Recreational hybrid PFD. 181.704 Section 181.704 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Flotation Devices § 181.704 Contents of information pamphlet: Recreational hybrid PFD. Each information pamphlet for a recreational hybrid PFD approved under 46 CFR 160.077 must contain the information...

  15. 33 CFR 181.704 - Contents of information pamphlet: Recreational hybrid PFD.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: Recreational hybrid PFD. 181.704 Section 181.704 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Flotation Devices § 181.704 Contents of information pamphlet: Recreational hybrid PFD. Each information pamphlet for a recreational hybrid PFD approved under 46 CFR 160.077 must contain the information...

  16. 19 CFR 181.51 - Prevention of improper payment of claims.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Prevention of improper payment of claims. 181.51 Section 181.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.51 Prevention of improper payment of claims. (a) Double payment of claim....

  17. 19 CFR 181.51 - Prevention of improper payment of claims.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Prevention of improper payment of claims. 181.51 Section 181.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.51 Prevention of improper payment of claims. (a) Double payment of claim....

  18. 19 CFR 181.51 - Prevention of improper payment of claims.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Prevention of improper payment of claims. 181.51 Section 181.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...-Deferral Programs § 181.51 Prevention of improper payment of claims. (a) Double payment of claim....

  19. 20 CFR 1002.181 - How is “prompt reemployment” defined?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How is âprompt reemploymentâ defined? 1002.181 Section 1002.181 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT... REEMPLOYMENT RIGHTS ACT OF 1994 Reemployment Rights and Benefits Prompt Reemployment § 1002.181 How is...

  20. Investigating the Impact of Asp181 Point Mutations on Interactions between PTP1B and Phosphotyrosine Substrate

    NASA Astrophysics Data System (ADS)

    Liu, Mengyuan; Wang, Lushan; Sun, Xun; Zhao, Xian

    2014-05-01

    Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling, which suggests that it is an attractive therapeutic target in type II diabetes and obesity. The aim of this research is to explore residues which interact with phosphotyrosine substrate can be affected by D181 point mutations and lead to increased substrate binding. To achieve this goal, molecular dynamics simulations were performed on wild type (WT) and two mutated PTP1B/substrate complexes. The cross-correlation and principal component analyses show that point mutations can affect the motions of some residues in the active site of PTP1B. Moreover, the hydrogen bond and energy decomposition analyses indicate that apart from residue 181, point mutations have influence on the interactions of substrate with several residues in the active site of PTP1B.

  1. MicroRNA-181b promotes ovarian cancer cell growth and invasion by targeting LATS2

    SciTech Connect

    Xia, Ying; Gao, Yan

    2014-05-09

    Highlights: • miR-181b is upregulated in human ovarian cancer tissues. • miR-181b promotes ovarian cancer cell proliferation and invasion. • LATS2 is a direct target of miR-181b. • LATS2 is involved in miR-181b-induced ovarian cancer cell growth and invasion. - Abstract: MicroRNAs (miRNAs) are strongly implicated in tumorigenesis and metastasis. In this study, we showed significant upregulation of miR-181b in ovarian cancer tissues, compared with the normal ovarian counterparts. Forced expression of miR-181b led to remarkably enhanced proliferation and invasion of ovarian cancer cells while its knockdown induced significant suppression of these cellular events. The tumor suppressor gene, LATS2 (large tumor suppressor 2), was further identified as a novel direct target of miR-181b. Specifically, miR-181b bound directly to the 3′-untranslated region (UTR) of LATS2 and suppressed its expression. Restoration of LATS2 expression partially reversed the oncogenic effects of miR-181b. Our results indicate that miR-181b promotes proliferation and invasion by targeting LATS2 in ovarian cancer cells. These findings support the utility of miR-181b as a potential diagnostic and therapeutic target for ovarian cancer.

  2. microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition

    NASA Astrophysics Data System (ADS)

    Parikh, Aditya; Lee, Christine; Joseph, Peronne; Marchini, Sergio; Baccarini, Alessia; Kolev, Valentin; Romualdi, Chiara; Fruscio, Robert; Shah, Hardik; Wang, Feng; Mullokandov, Gavriel; Fishman, David; D'Incalci, Maurizio; Rahaman, Jamal; Kalir, Tamara; Redline, Raymond W.; Brown, Brian D.; Narla, Goutham; Difeo, Analisa

    2014-01-01

    Ovarian cancer is a leading cause of cancer deaths among women. Effective targets to treat advanced epithelial ovarian cancer (EOC) and biomarkers to predict treatment response are still lacking because of the complexity of pathways involved in ovarian cancer progression. Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target, Smad7. miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC. Furthermore, ectopic expression of miR-181a results in increased cellular survival, migration, invasion, drug resistance and in vivo tumour burden and dissemination. In contrast, miR-181a inhibition via decoy vector suppression and Smad7 re-expression results in significant reversion of these phenotypes. Combined, our findings highlight an unappreciated role for miR-181a, Smad7, and the TGF-β signalling pathway in high-grade serous ovarian cancer.

  3. Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

    PubMed Central

    Santhanam, Ramasamy; Eisfeld, Ann-Kathrin; Chiang, Chi-ling; Lankenau, Malori; Yu, Bo; Hoellerbauer, Pia; Jin, Yan; Tarighat, Somayeh S.; Khalife, Jihane; Walker, Alison; Perrotti, Danilo; Bloomfield, Clara D.; Wang, Hongyan; Lee, Robert J.; Lee, Ly James; Marcucci, Guido

    2016-01-01

    Deregulation of microRNAs' expression frequently occurs in acute myeloid leukemia (AML). Lower miR-181a expression is associated with worse outcomes, but the exact mechanisms by which miR-181a mediates this effect remain elusive. Aberrant activation of the RAS pathway contributes to myeloid leukemogenesis. Here, we report that miR-181a directly binds to 3′-untranslated regions (UTRs); downregulates KRAS, NRAS and MAPK1; and decreases AML growth. The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles (NP) increased mature miR-181a; downregulated KRAS, NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors. NP-mediated upregulation of miR-181a led to reduced proliferation, impaired colony formation and increased sensitivity to chemotherapy. Ectopic expression of KRAS, NRAS and MAPK1 attenuated the anti-leukemic activity of miR-181a mimics, thereby validating the relevance of the deregulated miR-181a-RAS network in AML. Finally, treatment with miR-181a-NP in a murine AML model resulted in longer survival compared to mice treated with scramble-NP control. These data support that targeting the RAS-MAPK-pathway by miR-181a mimics represents a novel promising therapeutic approach for AML and possibly for other RAS-driven cancers. PMID:27517749

  4. Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK

    SciTech Connect

    Song, Mi-Kyung; Park, Yong-Keun; Ryu, Jae-Chun

    2013-11-15

    Growing evidence indicates that changes in microRNA (miRNA) expression in cancer induced by chemical carcinogens play an important role in cancer development and progression by regulating related genes. However, the mechanisms underlying miRNA involvement in hepatocarcinogenesis induced by polycyclic aromatic hydrocarbons (PAHs) remain unclear. Thus, the identification of aberrant miRNA expression during PAH-induced cancer cell migration will lead to a better understanding of the substantial role of miRNAs in cancer progression. In the present study, miRNA expression profiling showed significant upregulation of miR-181a, -181b, and -181d in human hepatocellular carcinoma cells (HepG2 line) exposed to benzo[a]anthracene (BA) and benzo[k]fluoranthene (BF). MAPK phosphatase-5 (MKP-5), a validated miR-181 target that deactivates MAPKs, was markedly suppressed while phosphorylation of p38 MAPK was increased after BA and BF exposure. The migration of HepG2 cells, observed using the scratch wound-healing assay, also increased in a dose-dependent manner. Depletion of miR-181 family members by miRNA inhibitors enhanced the expression of MKP-5 and suppressed the phosphorylation of p38 MAPK. Furthermore, the depletion of the miR-181 family inhibited cancer cell migration. Based on these results, we conclude that the miR-181 family plays a critical role in PAH-induced hepatocarcinogenesis by targeting MKP-5, resulting in the regulation of p38 MAPK activation. - Highlights: • We found significant upregulation of miR-181 family in HCC exposed to BA and BF. • We identified the MKP-5 as a putative target of miR-181 family. • MKP-5 was suppressed while p-P38 was increased after BA and BF exposure. • The migration of HepG2 cells increased in a dose-dependent manner.

  5. LEADING WITH LEADING INDICATORS

    SciTech Connect

    PREVETTE, S.S.

    2005-01-27

    This paper documents Fluor Hanford's use of Leading Indicators, management leadership, and statistical methodology in order to improve safe performance of work. By applying these methods, Fluor Hanford achieved a significant reduction in injury rates in 2003 and 2004, and the improvement continues today. The integration of data, leadership, and teamwork pays off with improved safety performance and credibility with the customer. The use of Statistical Process Control, Pareto Charts, and Systems Thinking and their effect on management decisions and employee involvement are discussed. Included are practical examples of choosing leading indicators. A statistically based color coded dashboard presentation system methodology is provided. These tools, management theories and methods, coupled with involved leadership and employee efforts, directly led to significant improvements in worker safety and health, and environmental protection and restoration at one of the nation's largest nuclear cleanup sites.

  6. 19 CFR 181.71 - Denial of preferential tariff treatment dependent on origin verification and determination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications and Determinations § 181.71 Denial of preferential...

  7. 19 CFR 181.71 - Denial of preferential tariff treatment dependent on origin verification and determination.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications and Determinations § 181.71 Denial of preferential...

  8. 19 CFR 181.71 - Denial of preferential tariff treatment dependent on origin verification and determination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications and Determinations § 181.71 Denial of preferential...

  9. 19 CFR 181.71 - Denial of preferential tariff treatment dependent on origin verification and determination.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Origin Verifications and Determinations § 181.71 Denial of preferential...

  10. Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons.

    PubMed

    Meijer, Marieke; Cijsouw, Tony; Toonen, Ruud F; Verhage, Matthijs

    2015-01-01

    The munc18-1 gene encodes two splice-variants that vary at the C-terminus of the protein and are expressed at different levels in different regions of the adult mammalian brain. Here, we investigated the expression pattern of these splice variants within the brainstem and tested whether they are functionally different. Munc18-1a is expressed in specific nuclei of the brainstem including the LRN, VII and SOC, while Munc18-1b expression is relatively low/absent in these regions. Furthermore, Munc18-1a is the major splice variant in the Calyx of Held. Synaptic transmission was analyzed in autaptic hippocampal munc18-1 KO neurons re-expressing either Munc18-1a or Munc18-1b. The two splice variants supported synaptic transmission to a similar extent, but Munc18-1b was slightly more potent in sustaining synchronous release during high frequency stimulation. Our data suggest that alternative splicing of Munc18-1 support synaptic transmission to a similar extent, but could modulate presynaptic short-term plasticity.

  11. Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons

    PubMed Central

    Toonen, Ruud F.; Verhage, Matthijs

    2015-01-01

    The munc18-1 gene encodes two splice-variants that vary at the C-terminus of the protein and are expressed at different levels in different regions of the adult mammalian brain. Here, we investigated the expression pattern of these splice variants within the brainstem and tested whether they are functionally different. Munc18-1a is expressed in specific nuclei of the brainstem including the LRN, VII and SOC, while Munc18-1b expression is relatively low/absent in these regions. Furthermore, Munc18-1a is the major splice variant in the Calyx of Held. Synaptic transmission was analyzed in autaptic hippocampal munc18-1 KO neurons re-expressing either Munc18-1a or Munc18-1b. The two splice variants supported synaptic transmission to a similar extent, but Munc18-1b was slightly more potent in sustaining synchronous release during high frequency stimulation. Our data suggest that alternative splicing of Munc18-1 support synaptic transmission to a similar extent, but could modulate presynaptic short-term plasticity. PMID:26407320

  12. Trans-18:1 isomers in rat milk fat as effective biomarkers for the determination of individual isomeric trans-18:1 acids in the dams' diet.

    PubMed

    Wolff, Robert L

    2003-11-01

    Female rats were fed a diet containing by weight 10% partially hydrogenated sunflower oil, 2% sunflower oil, and 1% rapeseed oil during gestation and lactation. The trans-18:1 isomer profile of the fat supplement was (in % of total trans 18:1 acids in the fat supplement): delta4, 0.5; delta5, 1.0; delta6-delta8, 18.0; delta9 (elaidic), 13.5; delta10, 22.2; delta11 (vaccenic), 16.0; delta12, 11.3; delta13-delta14, 12.8; delta15, 2.5; and delta16, 2.2 (total trans 18:1 acids in the fat supplement: 40.6%). The cis 18:1 isomer profile was (in % of total cis-18:1 isomers): delta6-delta8, 2.1; delta9 (oleic), 70.9; delta10, 6.1; delta11, 8.3; delta12, 4.0; delta13, 2.8; delta14, 4.6, and delta15, 1.2 (total cis-18:1 acids in the fat supplement: 32.6%). Suckling rats from four litters were sacrificed at day 17 or 18 after birth, and their stomach content (milk) was analyzed. The trans-18:1 isomer profile of milk was (relative proportions, in % of total): delta4, 0.3; delta5, 1.1; delta6-delta8, 16.8; delta9, 15.3; delta10, 22.0; delta11, 16.7; delta12, 11.8; delta13-14, 11.8; delta15, 2.5, and delta16, 1.9 (total trans 18:1 acids in milk: %). That of cis-18:1 isomers was (proportions in % relative to total cis-18:1 isomers): delta6-delta8, 4.7; delta9, 72.5; delta10, 4.0; delta11, 8.0; delta12, 7.1; delta13, 1.9; delta14, 1.0, and delta15, 0.7 (total cis-18:1 acids in milk: %). These results demonstrate that all isomeric acids, independent of the geometry and the position of the ethylenic bond, are incorporated into milk lipids. With regard to trans-18:1 isomers, the distribution profile in milk is identical to that in the dams' diet, i.e., there is no discrimination against any positional isomer between their ingestion and their deposition into milk lipids. As a consequence, this study indicates that the trans-18:1 isomer profile of milk reflects that in the dams' diet and supports our earlier hypothesis that the profile of trans-18:1 isomers in milk can be used to

  13. MiR-181b promotes chemoresistance in breast cancer by regulating Bim expression.

    PubMed

    Zheng, Yabing; Lv, Xiaoai; Wang, Xiaojia; Wang, Bei; Shao, Xiying; Huang, Yuan; Shi, Lei; Chen, Zhanhong; Huang, Jian; Huang, Ping

    2016-02-01

    MicroRNAs are emerging as critical regulators of the initiation and progression of multiple types of human cancers, including breast cancer. In the present study, the expression of miR-181b in breast cancer patient serum and breast cancer cell lines was evaluated. It was demonstrated that the miR-181b level was significantly upregulated in patient serum and breast cancer cell lines compared with that in normal controls. The results of in vitro 3H thymidine incorporation and Transwell migration assay indicated that miR-181b overexpression markedly promoted the proliferation and metastasis of breast cancer cells. These data suggest that miR-181b is a tumor promoter in breast cancer. Furthermore, miR-181b expression was found to be upregulated in doxorubicin (DOX)-resistant T-47D cells (T-47D-R) compared with that in the parental T-47D cells, and upregulation of miR-181b expression decreased the anticancer effect of DOX in the T-47D cells. Mechanistic studies demonstrated that the Bim gene, an essential initiator of apoptosis, was inhibited by miR-181b overexpression. We observed that knockdown of miR-181b by its specific inhibitors significantly re-sensitized the T-47D-R cells to the cytotoxicity of DOX. Importantly, we demonstrated that miR-181b inhibitors increased the level of Bim in the T-47D-R cells, resulting in the loss of mitochondrial membrane potential (MMP) and the activation of caspases caused by DOX. In summary, the results of the present study suggest that miR-181b functions as an oncogene during breast cancer development, and the miR-181b/Bim pathway may be a novel target used to overcome the chemoresistance in breast cancer.

  14. Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway.

    PubMed

    Zheng, Jianjian; Wu, Cunzao; Xu, Ziqiang; Xia, Peng; Dong, Peihong; Chen, Bicheng; Yu, Fujun

    2015-01-01

    Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and progression of liver fibrosis. MicroRNAs have been shown to play a pivotal role in regulating HSC functions such as cell proliferation, differentiation, and apoptosis. Recently, miR-181b has been reported to promote HSCs proliferation by targeting p27. But whether alpha-smooth muscle actin (α-SMA) or collagens could be promoted by miR-181b in activated HSCs is still not clear. Therefore, the understanding of the role of miR-181b in liver fibrosis remains limited. Our results showed that miR-181b expression was increased much higher than miR-181a expression in vitro in transforming growth factor-β1-induced HSC activation as well as in vivo in carbon tetrachloride-induced rat liver fibrosis. Of note, overexpression of miR-181b significantly increased the expressions level of α-SMA and type I collagen, and further promoted HSCs proliferation. Furthermore, phosphatase and tensin homologs deleted on chromosome 10 (PTEN), a negative regulator of PI3K/Akt pathway, were confirmed as a direct target of miR-181b. We demonstrated that miR-181b could suppress PTEN expression and increase Akt phosphorylation in HSCs. Interestingly, the effects of miR-181b on the activation of HSCs were blocked down by Akt inhibitor LY294002. Our results revealed a profibrotic role of miR-181b in HSC activation and demonstrated that miR-181b could activate HSCs, at least in part, via PTEN/Akt pathway.

  15. Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.

    PubMed

    Wang, Hongjun; Tao, Tao; Yan, Wei; Feng, Yan; Wang, Yongzhi; Cai, Jinquan; You, Yongping; Jiang, Tao; Jiang, Chuanlu

    2015-08-18

    The goal of this work was to explore the most effective miRNAs affecting glioblastoma multiforme (GBM) phenotype transition and malignant progression. We annotated 491 TCGA samples' miRNA expression profiles according to their mRNA-based subtypes and found that the mesenchymal tumors had significantly decreased miR-181 family expression compared with the other three subtypes while the proneural subtype harbored extremely high miR-181 family expression. Patients with high miR-181 family expression had longer overall survival (p = 0.0031). We also confirmed that NF-κB-targeting genes and the EMT (epithelial-mesenchymal transition) pathway were inversely correlated with miR-181 family expression and that the entire miR-181 family inhibited glioma cell invasion and proliferation; of these, miR-181b was the most effective suppressor. Furthermore, miR-181b was validated to suppress EMT by targeting KPNA4 and was associated with survival outcome in the TCGA and CGGA datasets and in another independent cohort. The EMT-inhibitory effect of miR-181b was lost after KPNA4 expression was restored. We also identified the antitumorigenic activity of miR-181b in vitro and in vivo. Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b, a tumor-suppressive miRNA, could be a novel therapeutic candidate for treating gliomas.

  16. 19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Withdrawal of NAFTA advance ruling requests. 181.97 Section 181.97 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the...

  17. 19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Withdrawal of NAFTA advance ruling requests. 181.97 Section 181.97 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the...

  18. 19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Withdrawal of NAFTA advance ruling requests. 181.97 Section 181.97 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the...

  19. 19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Withdrawal of NAFTA advance ruling requests. 181.97 Section 181.97 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the...

  20. 19 CFR 181.97 - Withdrawal of NAFTA advance ruling requests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Withdrawal of NAFTA advance ruling requests. 181.97 Section 181.97 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Withdrawal of NAFTA advance ruling requests. Any request for an advance ruling may be withdrawn by the...

  1. 21 CFR 181.26 - Drying oils as components of finished resins.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) shall include: Chinawood oil (tung oil). Dehydrated castor oil. Linseed oil. Tall oil. ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Drying oils as components of finished resins. 181... Prior-Sanctioned Food Ingredients § 181.26 Drying oils as components of finished resins....

  2. 21 CFR 181.26 - Drying oils as components of finished resins.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) shall include: Chinawood oil (tung oil). Dehydrated castor oil. Linseed oil. Tall oil. ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Drying oils as components of finished resins. 181... Prior-Sanctioned Food Ingredients § 181.26 Drying oils as components of finished resins....

  3. 21 CFR 181.26 - Drying oils as components of finished resins.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) shall include: Chinawood oil (tung oil). Dehydrated castor oil. Linseed oil. Tall oil. ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Drying oils as components of finished resins. 181... Prior-Sanctioned Food Ingredients § 181.26 Drying oils as components of finished resins....

  4. 21 CFR 181.26 - Drying oils as components of finished resins.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) shall include: Chinawood oil (tung oil). Dehydrated castor oil. Linseed oil. Tall oil. ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Drying oils as components of finished resins. 181... Prior-Sanctioned Food Ingredients § 181.26 Drying oils as components of finished resins....

  5. 19 CFR 181.46 - Time and place for filing drawback claim.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Time and place for filing drawback claim. 181.46 Section 181.46 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  6. 19 CFR 181.31 - Right to make post-importation claim and refund duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Right to make post-importation claim and refund duties. 181.31 Section 181.31 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Post-Importation...

  7. 19 CFR 181.51 - Prevention of improper payment of claims.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Prevention of improper payment of claims. 181.51 Section 181.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  8. 19 CFR 181.46 - Time and place for filing drawback claim.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Time and place for filing drawback claim. 181.46 Section 181.46 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  9. 19 CFR 181.23 - Effect of noncompliance; failure to provide documentation regarding transshipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Effect of noncompliance; failure to provide documentation regarding transshipment. 181.23 Section 181.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE...

  10. 19 CFR 181.42 - Duties and fees not subject to drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Duties and fees not subject to drawback. 181.42 Section 181.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  11. 19 CFR 181.23 - Effect of noncompliance; failure to provide documentation regarding transshipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Effect of noncompliance; failure to provide documentation regarding transshipment. 181.23 Section 181.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE...

  12. 19 CFR 181.31 - Right to make post-importation claim and refund duties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Right to make post-importation claim and refund duties. 181.31 Section 181.31 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Post-Importation...

  13. 19 CFR 181.23 - Effect of noncompliance; failure to provide documentation regarding transshipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Effect of noncompliance; failure to provide documentation regarding transshipment. 181.23 Section 181.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE...

  14. 19 CFR 181.42 - Duties and fees not subject to drawback.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Duties and fees not subject to drawback. 181.42 Section 181.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  15. 19 CFR 181.50 - Liquidation and payment of drawback claims.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Liquidation and payment of drawback claims. 181.50 Section 181.50 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  16. 19 CFR 181.50 - Liquidation and payment of drawback claims.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Liquidation and payment of drawback claims. 181.50 Section 181.50 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE AGREEMENT Restrictions on Drawback and...

  17. 19 CFR 181.23 - Effect of noncompliance; failure to provide documentation regarding transshipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Effect of noncompliance; failure to provide documentation regarding transshipment. 181.23 Section 181.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) NORTH AMERICAN FREE TRADE...

  18. 46 CFR 69.181 - Locating the line of the second deck.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Locating the line of the second deck. 69.181 Section 69... VESSELS MEASUREMENT OF VESSELS Dual Measurement System § 69.181 Locating the line of the second deck. (a) If the second deck is not stepped, the line of the second deck is the longitudinal line of...

  19. 46 CFR 69.181 - Locating the line of the second deck.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Locating the line of the second deck. 69.181 Section 69... VESSELS MEASUREMENT OF VESSELS Dual Measurement System § 69.181 Locating the line of the second deck. (a) If the second deck is not stepped, the line of the second deck is the longitudinal line of...

  20. 46 CFR 69.181 - Locating the line of the second deck.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Locating the line of the second deck. 69.181 Section 69... VESSELS MEASUREMENT OF VESSELS Dual Measurement System § 69.181 Locating the line of the second deck. (a) If the second deck is not stepped, the line of the second deck is the longitudinal line of...

  1. 46 CFR 69.181 - Locating the line of the second deck.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Locating the line of the second deck. 69.181 Section 69... VESSELS MEASUREMENT OF VESSELS Dual Measurement System § 69.181 Locating the line of the second deck. (a) If the second deck is not stepped, the line of the second deck is the longitudinal line of...

  2. 46 CFR 69.181 - Locating the line of the second deck.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Locating the line of the second deck. 69.181 Section 69... VESSELS MEASUREMENT OF VESSELS Dual Measurement System § 69.181 Locating the line of the second deck. (a) If the second deck is not stepped, the line of the second deck is the longitudinal line of...

  3. 19 CFR 181.52 - Subsequent claims for preferential tariff treatment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Subsequent claims for preferential tariff treatment. 181.52 Section 181.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... claim for a refund of duties is allowed by the Canadian or Mexican customs administration under...

  4. 19 CFR 181.113 - Request for basis of adverse marking decision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Request for basis of adverse marking decision. 181.113 Section 181.113 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... case of a Mexican exporter or producer, the Federal taxpayer registry number (RFC); and the...

  5. 19 CFR 181.54 - Verification of claim for drawback, waiver or reduction of duties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Verification of claim for drawback, waiver or reduction of duties. 181.54 Section 181.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... this subpart shall be subject to such verification, including verification with the Canadian or...

  6. 19 CFR 181.102 - Administrative and judicial review of advance rulings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... rulings. 181.102 Section 181.102 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND..., Regulations and Rulings, Office of International Trade, U.S. Customs and Border Protection, Washington, DC...) in the case of a Mexican exporter or producer and authorized agent thereof; (iii) The number and...

  7. 19 CFR 181.54 - Verification of claim for drawback, waiver or reduction of duties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Verification of claim for drawback, waiver or reduction of duties. 181.54 Section 181.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... this subpart shall be subject to such verification, including verification with the Canadian or...

  8. 19 CFR 181.54 - Verification of claim for drawback, waiver or reduction of duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Verification of claim for drawback, waiver or reduction of duties. 181.54 Section 181.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... this subpart shall be subject to such verification, including verification with the Canadian or...

  9. 19 CFR 181.54 - Verification of claim for drawback, waiver or reduction of duties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Verification of claim for drawback, waiver or reduction of duties. 181.54 Section 181.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... this subpart shall be subject to such verification, including verification with the Canadian or...

  10. 19 CFR 181.102 - Administrative and judicial review of advance rulings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... rulings. 181.102 Section 181.102 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND..., Regulations and Rulings, Office of International Trade, U.S. Customs and Border Protection, Washington, DC...) in the case of a Mexican exporter or producer and authorized agent thereof; (iii) The number and...

  11. 19 CFR 181.113 - Request for basis of adverse marking decision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Request for basis of adverse marking decision. 181.113 Section 181.113 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... case of a Mexican exporter or producer, the Federal taxpayer registry number (RFC); and the...

  12. 19 CFR 181.52 - Subsequent claims for preferential tariff treatment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Subsequent claims for preferential tariff treatment. 181.52 Section 181.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... claim for a refund of duties is allowed by the Canadian or Mexican customs administration under...

  13. 19 CFR 181.102 - Administrative and judicial review of advance rulings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... rulings. 181.102 Section 181.102 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND..., Regulations and Rulings, Office of International Trade, U.S. Customs and Border Protection, Washington, DC...) in the case of a Mexican exporter or producer and authorized agent thereof; (iii) The number and...

  14. 19 CFR 181.113 - Request for basis of adverse marking decision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Request for basis of adverse marking decision. 181.113 Section 181.113 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... case of a Mexican exporter or producer, the Federal taxpayer registry number (RFC); and the...

  15. 19 CFR 181.54 - Verification of claim for drawback, waiver or reduction of duties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Verification of claim for drawback, waiver or reduction of duties. 181.54 Section 181.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... this subpart shall be subject to such verification, including verification with the Canadian or...

  16. 19 CFR 181.52 - Subsequent claims for preferential tariff treatment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Subsequent claims for preferential tariff treatment. 181.52 Section 181.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... claim for a refund of duties is allowed by the Canadian or Mexican customs administration under...

  17. 19 CFR 181.102 - Administrative and judicial review of advance rulings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... rulings. 181.102 Section 181.102 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND..., Regulations and Rulings, Office of International Trade, U.S. Customs and Border Protection, Washington, DC...) in the case of a Mexican exporter or producer and authorized agent thereof; (iii) The number and...

  18. 19 CFR 181.52 - Subsequent claims for preferential tariff treatment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Subsequent claims for preferential tariff treatment. 181.52 Section 181.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... claim for a refund of duties is allowed by the Canadian or Mexican customs administration under...

  19. 19 CFR 181.52 - Subsequent claims for preferential tariff treatment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Subsequent claims for preferential tariff treatment. 181.52 Section 181.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... claim for a refund of duties is allowed by the Canadian or Mexican customs administration under...

  20. 19 CFR 181.113 - Request for basis of adverse marking decision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Request for basis of adverse marking decision. 181.113 Section 181.113 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... case of a Mexican exporter or producer, the Federal taxpayer registry number (RFC); and the...

  1. 26 CFR 1.181-1T - Deduction for qualified film and television production costs (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Deduction for qualified film and television... Individuals and Corporations (continued) § 1.181-1T Deduction for qualified film and television production... section) of any film or television production (as defined in § 1.181-3T(b)) that the owner...

  2. 26 CFR 1.181-1T - Deduction for qualified film and television production costs (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Deduction for qualified film and television... Individuals and Corporations (continued) § 1.181-1T Deduction for qualified film and television production... concerning qualified film and television productions. Section 1.181-4 provides special rules, including...

  3. 26 CFR 1.181-1 - Deduction for qualified film and television production costs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 3 2013-04-01 2013-04-01 false Deduction for qualified film and television... and Corporations (continued) § 1.181-1 Deduction for qualified film and television production costs... film or television production (production, as defined in § 1.181-3(b)) that the owner...

  4. 26 CFR 1.181-1 - Deduction for qualified film and television production costs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Deduction for qualified film and television... and Corporations (continued) § 1.181-1 Deduction for qualified film and television production costs... film or television production (production, as defined in § 1.181-3(b)) that the owner...

  5. 26 CFR 1.181-1 - Deduction for qualified film and television production costs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 3 2014-04-01 2014-04-01 false Deduction for qualified film and television... and Corporations (continued) § 1.181-1 Deduction for qualified film and television production costs... film or television production (production, as defined in § 1.181-3(b)) that the owner...

  6. 42 CFR 456.181 - Reports of evaluations and plans of care.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Reports of evaluations and plans of care. 456.181 Section 456.181 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental...

  7. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Twenty-day rule for concluded agreements. 181.5... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency... for Treaty Affairs as soon as possible and in no event to arrive at that office later than 20...

  8. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Twenty-day rule for concluded agreements. 181.5... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency... for Treaty Affairs as soon as possible and in no event to arrive at that office later than 20...

  9. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Twenty-day rule for concluded agreements. 181.5... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency... for Treaty Affairs as soon as possible and in no event to arrive at that office later than 20...

  10. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Twenty-day rule for concluded agreements. 181.5... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency... for Treaty Affairs as soon as possible and in no event to arrive at that office later than 20...

  11. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Twenty-day rule for concluded agreements. 181.5... PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency... for Treaty Affairs as soon as possible and in no event to arrive at that office later than 20...

  12. 26 CFR 1.181-6T - Effective/applicability dates (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... paragraph (b) of this section, § 1.181-1T applies to productions, the first day of principal photography for... animation” in place of “principal photography.” Productions involving both animation and live-action photography may use either standard. (2) The applicability of § 1.181-1T expires on October 17, 2014....

  13. 42 CFR 456.181 - Reports of evaluations and plans of care.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Plan of Care § 456.181 Reports of evaluations and plans of care. A written report of each evaluation... 42 Public Health 4 2010-10-01 2010-10-01 false Reports of evaluations and plans of care. 456.181... evaluation or plan. Utilization Review (UR) Plan: General Requirements...

  14. Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

    PubMed

    Meijer, Marieke; Burkhardt, Pawel; de Wit, Heidi; Toonen, Ruud F; Fasshauer, Dirk; Verhage, Matthijs

    2012-05-02

    Synaptic transmission depends critically on the Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion machinery or has a more upstream role in fusion complex assembly. Here, we show that point mutations in Munc18-1 that interfere with binding to the free Syntaxin1a N-terminus and strongly impair binding to assembled SNARE complexes all support normal docking, priming and fusion of synaptic vesicles, and normal synaptic plasticity in munc18-1 null mutant neurons. These data support a prevailing role of Munc18-1 before/during SNARE-complex assembly, while its continued association to assembled SNARE complexes is dispensable for synaptic transmission.

  15. Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

    PubMed Central

    Meijer, Marieke; Burkhardt, Pawel; de Wit, Heidi; Toonen, Ruud F; Fasshauer, Dirk; Verhage, Matthijs

    2012-01-01

    Synaptic transmission depends critically on the Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion machinery or has a more upstream role in fusion complex assembly. Here, we show that point mutations in Munc18-1 that interfere with binding to the free Syntaxin1a N-terminus and strongly impair binding to assembled SNARE complexes all support normal docking, priming and fusion of synaptic vesicles, and normal synaptic plasticity in munc18-1 null mutant neurons. These data support a prevailing role of Munc18-1 before/during SNARE-complex assembly, while its continued association to assembled SNARE complexes is dispensable for synaptic transmission. PMID:22446389

  16. MicroRNA-181b regulates NF-κB-mediated vascular inflammation.

    PubMed

    Sun, Xinghui; Icli, Basak; Wara, Akm Khyrul; Belkin, Nathan; He, Shaolin; Kobzik, Lester; Hunninghake, Gary M; Vera, Miguel Pinilla; Blackwell, Timothy S; Baron, Rebecca M; Feinberg, Mark W

    2012-06-01

    EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC activation and inflammation remains poorly understood. Herein, we report that microRNA-181b (miR-181b) serves as a potent regulator of downstream NF-κB signaling in the vascular endothelium by targeting importin-α3, a protein that is required for nuclear translocation of NF-κB. Overexpression of miR-181b inhibited importin-α3 expression and an enriched set of NF-κB-responsive genes such as adhesion molecules VCAM-1 and E-selectin in ECs in vitro and in vivo. In addition, treatment of mice with proinflammatory stimuli reduced miR-181b expression. Rescue of miR-181b levels by systemic administration of miR-181b "mimics" reduced downstream NF-κB signaling and leukocyte influx in the vascular endothelium and decreased lung injury and mortality in endotoxemic mice. In contrast, miR-181b inhibition exacerbated endotoxin-induced NF-κB activity, leukocyte influx, and lung injury. Finally, we observed that critically ill patients with sepsis had reduced levels of miR-181b compared with control intensive care unit (ICU) subjects. Collectively, these findings demonstrate that miR-181b regulates NF-κB-mediated EC activation and vascular inflammation in response to proinflammatory stimuli and that rescue of miR-181b expression could provide a new target for antiinflammatory therapy and critical illness.

  17. miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

    SciTech Connect

    Shin, Ki-Hyuk; Bae, Susan D.; Hong, Hannah S.; Kim, Reuben H.; Kang, Mo K.; Park, No-Hee

    2011-01-28

    Research highlights: {yields} MicroRNA-181a (miR-181a) was frequently downregulated in oral squamous cell carcinoma (OSCC). {yields} Overexpression of miR-181a suppressed OSCC growth. {yields} K-ras is a novel target of miR-181a. {yields} Decreased miR-181a expression is attributed to its lower promoter activity in OSCC. -- Abstract: MicroRNAs (miRNAs) are epigenetic regulators of gene expression, and their deregulation plays an important role in human cancer, including oral squamous cell carcinoma (OSCC). Recently, we found that miRNA-181a (miR-181a) was upregulated during replicative senescence of normal human oral keratinocytes. Since senescence is considered as a tumor suppressive mechanism, we thus investigated the expression and biological role of miR-181a in OSCC. We found that miR-181a was frequently downregulated in OSCC. Ectopic expression of miR-181a suppressed proliferation and anchorage independent growth ability of OSCC. Moreover, miR-181a dramatically reduces the growth of OSCC on three dimensional organotypic raft culture. We also identified K-ras as a novel target of miR-181a. miR-181a decreased K-ras protein level as well as the luciferase activity of reporter vectors containing the 3'-untranslated region of K-ras gene. Finally, we defined a minimal regulatory region of miR-181a and found a positive correlation between its promoter activity and the level of miR-181a expression. In conclusion, miR-181a may function as an OSCC suppressor by targeting on K-ras oncogene. Thus, miR-181a should be considered for therapeutic application for OSCC.

  18. Lead Poisoning

    MedlinePlus

    ... be exposed to lead by Eating food or drinking water that contains lead. Water pipes in older homes ... herbs or foods that contain lead Breathing air, drinking water, eating food, or swallowing or touching dirt that ...

  19. Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs.

    PubMed

    Presnell, S R; Al-Attar, A; Cichocki, F; Miller, J S; Lutz, C T

    2015-01-01

    Natural killer (NK) and T lymphocytes share many properties, yet only NK cells respond rapidly to infection and cancer without pre-activation. We found that few microRNAs (miRNAs) differed significantly between human NK and T cells. Among those miRNAs, miR-181a and miR-181b levels rose during NK cell differentiation. Prior studies indicate that miR-181a and miR-181b are critical for human NK cell development and are co-transcribed from genes on chromosome 1 (MIR181A1B1) and on chromosome 9 (MIR181A2B2). We mapped human MIR181A1B1 and MIR181A2B2 transcription start sites to 78.3 kb and 34.0 kb upstream of the mature miRNAs, generating predominantly unspliced transcripts of 80-127 kb and ~60 kb, respectively. Unlike mouse thymocytes, human T cells expressed both MIR181A1B1 and MIR181A2B2. We tested the hypothesis that NK cells differentially transcribe the two genes during development and in response to immune regulatory cytokines. During NK-cell differentiation, MIR181A2B2 expression rose markedly and exceeded that of MIR181A1B1. TGF-β treatment increased NK-cell MIR181A2B2 transcription, whereas IL-2, IL-15 and IL-12/IL-18 treatments upregulated MIR181A1B1. The MIR181A2B2 promoter was strongly transactivated by SMAD3 and SMAD4 transcription factors, suggesting that TGF-β signaling upregulates MIR181A2B2 expression, at least in part, through SMAD-dependent promoter activation.

  20. Lead Toxicity

    MedlinePlus

    ... including some imported jewelry. What are the health effects of lead? • More commonly, lower levels of lead in children over time may lead to reduced IQ, slow learning, Attention Deficit Hyperactivity Disorder (ADHD), or behavioral issues. • Lead also affects other ...

  1. Lead poisoning

    SciTech Connect

    Rekus, J.F.

    1992-08-01

    Construction workers who weld, cut or blast structural steel coated with lead-based paint are at significant risk of lead poisoning. Although technology to control these exposures may not have existed when the lead standard was promulgated, it is available today. Employers who do not take steps to protect their employees from lead exposure may be cited and fined severely for their failure.

  2. MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity.

    PubMed

    Song, Jinsoo; Lee, Myeungsu; Kim, Dongkyun; Han, Jiyeon; Chun, Churl-Hong; Jin, Eun-Jung

    2013-02-08

    MicroRNAs are endogenous gene regulators that have been implicated in various developmental and pathological processes. However, the precise identities and functions of the miRNAs involved in cartilage development are not yet well understood. Here, we report that miR-181b regulates chondrocyte differentiation and maintains cartilage integrity, and is thus a potent therapeutic target. MiR-181b was significantly down-regulated during chondrogenic differentiation of TGF-β3-stimulated limb mesenchymal cells, but it was significantly up-regulated in osteoarthritic chondrocytes isolated from the cartilage of osteoarthritis patients. The use of a mimic or an inhibitor to alter miR-181b levels in chondroblasts and articular chondrocytes showed that attenuation of miR-181b reduced MMP-13 expression while inducing type II collagen expression. Furthermore, over-expression of anti-miR-181b significantly reduced the cartilage destruction caused by DMM surgery in mice. In sum, our data suggest that miR-181b is a negative regulator of cartilage development, and that inhibition of miR-181b could be an effective therapeutic strategy for cartilage-related disease.

  3. Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3.

    PubMed

    Heath, Jack M; Fernandez Esmerats, Joan; Khambouneheuang, Lucky; Kumar, Sandeep; Simmons, Rachel; Jo, Hanjoong

    2017-02-24

    Calcific aortic valve disease (CAVD) is a major cause of morbidity in the aging population, but the underlying mechanisms of its progression remain poorly understood. Aortic valve calcification preferentially occurs on the fibrosa, which is subjected to disturbed flow. The side-specific progression of the disease is characterized by inflammation, calcific lesions, and extracellular matrix (ECM) degradation. Here, we explored the role of mechanosensitive microRNA-181b and its downstream targets in human aortic valve endothelial cells (HAVECs). Mechanistically, miR-181b is upregulated in OS and fibrosa, and it targets TIMP3, SIRT1, and GATA6, correlated with increased gelatinase/MMP activity. Overexpression of miR-181b led to decreased TIMP3 and exacerbated MMP activity as shown by gelatinase assay, and miR-181b inhibition decreased gelatinase activity through the repression of TIMP3 levels. Luciferase assay showed specific binding of miR-181b to the TIMP3 gene. Overexpression of miR-181b in HAVECs subjected to either LS or OS increased MMP activity, and miR-181b inhibition abrogated shear-sensitive MMP activity. These studies suggest that targeting this shear-dependent miRNA may provide a novel noninvasive treatment for CAVD.

  4. MicroRNA-181b promotes ovarian cancer cell growth and invasion by targeting LATS2.

    PubMed

    Xia, Ying; Gao, Yan

    2014-05-09

    MicroRNAs (miRNAs) are strongly implicated in tumorigenesis and metastasis. In this study, we showed significant upregulation of miR-181b in ovarian cancer tissues, compared with the normal ovarian counterparts. Forced expression of miR-181b led to remarkably enhanced proliferation and invasion of ovarian cancer cells while its knockdown induced significant suppression of these cellular events. The tumor suppressor gene, LATS2 (large tumor suppressor 2), was further identified as a novel direct target of miR-181b. Specifically, miR-181b bound directly to the 3'-untranslated region (UTR) of LATS2 and suppressed its expression. Restoration of LATS2 expression partially reversed the oncogenic effects of miR-181b. Our results indicate that miR-181b promotes proliferation and invasion by targeting LATS2 in ovarian cancer cells. These findings support the utility of miR-181b as a potential diagnostic and therapeutic target for ovarian cancer.

  5. Glutamic acid 181 is negatively charged in the bathorhodopsin photointermediate of visual rhodopsin

    PubMed Central

    Sandberg, Megan N.; Amora, Tabitha L.; Ramos, Lavoisier S.; Chen, Min-Hsuan; Knox, Barry E.; Birge, Robert R.

    2011-01-01

    Assignment of the protonation state of the residue Glu-181 is important to our understanding of the primary event, activation processes and wavelength selection in rhodopsin. Despite extensive study, there is no general agreement on the protonation state of this residue in the literature. Electronic assignment is complicated by the location of Glu-181 near the nodal point in the electrostatic charge shift that accompanies excitation of the chromophore into the low-lying, strongly allowed ππ* state. Thus, the charge on this residue is effectively hidden from electronic spectroscopy. This situation is resolved in bathorhodopsin, because photoisomerization of the chromophore places Glu-181 well within the region of negative charge shift following excitation. We demonstrate that Glu-181 is negatively charged in bathorhodopsin based on the shift in the batho absorption maxima at 10K [λmax band (native)= 544±2 nm, λmax band (E181Q)= 556±3 nm] and the decrease in the λmax band oscillator strength (0.069±0.004) of E181Q relative to the native protein. Because the primary event in rhodopsin does not include a proton translocation or disruption of the hydrogen-bonding network within the binding pocket, we may conclude that the Glu-181 residue in rhodopsin is also charged. PMID:21319741

  6. 12 CFR 225.181 - Conformance Period for Banking Entities Engaged in Prohibited Proprietary Trading or Private Fund...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Trading and Relationships With Hedge Funds and Private Equity Funds § 225.181 Conformance Period for... or hedge fund if— (i) The fund is an illiquid fund; and (ii) The acquisition or retention of such... in Prohibited Proprietary Trading or Private Fund Activities. 225.181 Section 225.181 Banks...

  7. 12 CFR 225.181 - Conformance Period for Banking Entities Engaged in Prohibited Proprietary Trading or Private Fund...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Trading and Relationships With Hedge Funds and Private Equity Funds § 225.181 Conformance Period for... or hedge fund if— (i) The fund is an illiquid fund; and (ii) The acquisition or retention of such... in Prohibited Proprietary Trading or Private Fund Activities. 225.181 Section 225.181 Banks...

  8. 12 CFR 225.181 - Conformance Period for Banking Entities Engaged in Prohibited Proprietary Trading or Private Fund...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Relationships With Hedge Funds and Private Equity Funds § 225.181 Conformance Period for Banking Entities... interest in, or otherwise provide additional capital to, a private equity fund or hedge fund if— (i) The... in Prohibited Proprietary Trading or Private Fund Activities. 225.181 Section 225.181 Banks...

  9. 19 CFR 181.53 - Collection and waiver or reduction of duty under duty-deferral programs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... duty-deferral programs. 181.53 Section 181.53 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Canada or Mexico as reflected on the applicable Canadian or Mexican entry document (see § 181.47(c) (1... or Mexico or for entry into a Canadian or Mexican duty-deferral program. Such measures...

  10. 19 CFR 181.53 - Collection and waiver or reduction of duty under duty-deferral programs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... duty-deferral programs. 181.53 Section 181.53 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... Canada or Mexico as reflected on the applicable Canadian or Mexican entry document (see § 181.47(c) (1... or Mexico or for entry into a Canadian or Mexican duty-deferral program. Such measures...

  11. Psychiatric epidemiologic study of occupational lead exposure

    SciTech Connect

    Parkinson, D.K.; Ryan, C.; Bromet, E.J.; Connell, M.M.

    1986-02-01

    The association of occupational lead exposure with neuropsychiatric functioning was evaluated using data collected in 1982 in eastern Pennsylvania from 288 lead-exposed workers and 181 nonexposed subjects. Both current and cumulative exposure indices were used. After controlling for age, education, and income, few meaningful differences between exposed and control workers were found on either neuropsychologic or psychosocial variables. Dose-response analyses indicated that among lead-exposed workers, cumulative and current exposure were unrelated to neuropsychologic performance. The only meaningful associations occurred between exposure and level of conflict in interpersonal relationships. The results thus give evidence against hypotheses suggesting adverse neuropsychologic effects.

  12. Low-Temperature Trapping of Photointermediates of the Rhodopsin E181Q Mutant.

    PubMed

    Sandberg, Megan N; Greco, Jordan A; Wagner, Nicole L; Amora, Tabitha L; Ramos, Lavoisier A; Chen, Min-Hsuan; Knox, Barry E; Birge, Robert R

    Three active-site components in rhodopsin play a key role in the stability and function of the protein: 1) the counter-ion residues which stabilize the protonated Schiff base, 2) water molecules, and 3) the hydrogen-bonding network. The ionizable residue Glu-181, which is involved in an extended hydrogen-bonding network with Ser-186, Tyr-268, Tyr-192, and key water molecules within the active site of rhodopsin, has been shown to be involved in a complex counter-ion switch mechanism with Glu-113 during the photobleaching sequence of the protein. Herein, we examine the photobleaching sequence of the E181Q rhodopsin mutant by using cryogenic UV-visible spectroscopy to further elucidate the role of Glu-181 during photoactivation of the protein. We find that lower temperatures are required to trap the early photostationary states of the E181Q mutant compared to native rhodopsin. Additionally, a Blue Shifted Intermediate (BSI, λmax = 498 nm, 100 K) is observed after the formation of E181Q Bathorhodopsin (Batho, λmax = 556 nm, 10 K) but prior to formation of E181Q Lumirhodopsin (Lumi, λmax = 506 nm, 220 K). A potential energy diagram of the observed photointermediates suggests the E181Q Batho intermediate has an enthalpy value 7.99 KJ/mol higher than E181Q BSI, whereas in rhodopsin, the BSI is 10.02 KJ/mol higher in enthalpy than Batho. Thus, the Batho to BSI transition is enthalpically driven in E181Q and entropically driven in native rhodopsin. We conclude that the substitution of Glu-181 with Gln-181 results in a significant perturbation of the hydrogen-bonding network within the active site of rhodopsin. In addition, the removal of a key electrostatic interaction between the chromophore and the protein destabilizes the protein in both the dark state and Batho intermediate conformations while having a stabilizing effect on the BSI conformation. The observed destabilization upon this substitution further supports that Glu-181 is negatively charged in the early

  13. Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

    PubMed Central

    Yue, Sibiao; Chen, Chang-Zheng

    2008-01-01

    Background Mature miRNAs can often be classified into large families, consisting of members with identical seeds (nucleotides 2 through 7 of the mature miRNAs) and highly homologous ∼21-nucleotide (nt) mature miRNA sequences. However, it is unclear whether members of a miRNA gene family, which encode identical or nearly identical mature miRNAs, are functionally interchangeable in vivo. Methods and Findings We show that mir-181a-1, but not mir-181c, can promote CD4 and CD8 double-positive (DP) T cell development when ectopically expressed in thymic progenitor cells. The distinct activities of mir-181a-1 and mir-181c are largely determined by their unique pre-miRNA loop nucleotides—not by the one-nucleotide difference in their mature miRNA sequences. Moreover, the activity of mir-181a-1 on DP cell development can be quantitatively influenced by nucleotide changes in its pre-miRNA loop region. We find that both the strength and the functional specificity of miRNA genes can be controlled by the pre-miRNA loop nucleotides. Intriguingly, we note that mutations in the pre-miRNA loop regions affect pre-miRNA and mature miRNA processing, but find no consistent correlation between the effects of pre-miRNA loop mutations on the levels of mature miRNAs and the activities of the mir-181a-1/c genes. Conclusions These results demonstrate that pre-miRNA loop nucleotides play a critical role in controlling the activity of miRNA genes and that members of the same miRNA gene families could have evolved to achieve different activities via alterations in their pre-miRNA loop sequences, while maintaining identical or nearly identical mature miRNA sequences. PMID:18974849

  14. MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1.

    PubMed

    An, Tian-Hui; He, Quan-Wei; Xia, Yuan-Peng; Chen, Sheng-Cai; Baral, Suraj; Mao, Ling; Jin, Hui-Juan; Li, Ya-Nan; Wang, Meng-Die; Chen, Jian-Guo; Zhu, Ling-Qiang; Hu, Bo

    2016-10-08

    Atherosclerotic plaque vulnerability is the major cause for acute stroke and could be regulated by macrophage polarization. MicroRNA-181b (miR-181b) was involved in macrophage differential. Here, we explore whether miR-181b could regulate atherosclerotic plaque vulnerability by modulating macrophage polarization and the underline mechanisms. In acute stroke patients with atherosclerotic plaque, we found that the serum level of miR-181b was decreased. Eight-week apolipoprotein E knockout (ApoE(-/-)) mice were randomly divided into three groups (N = 10): mice fed with normal saline (Ctrl), mice fed with high-fat diet, and tail vein injection with miRNA agomir negative control (AG-NC)/miR-181b agomir (181b-AG, a synthetic miR-181b agonist). We found that the serum level of miR-181b in AG-NC group was lower than that in Ctrl group. Moreover, 181b-AG could upregulate miR-181b expression, reduce artery burden and attenuate atherosclerotic plaque vulnerability by modulating macrophage polarization. In RAW264.7 cells treated with oxidized low-density lipoprotein (ox-LDL), we found miR-181b could reverse the function of ox-LDL on M1/M2 markers at both mRNA and protein levels. Furthermore, by employing luciferase reporter assay, we found that Notch1 was a direct target of miR-181b and could be regulated by miR-181b in vivo and in vitro. Finally, inhibition of Notch1 could abolish the function of downregulating miR-181b on increasing M2 phenotype macrophages. Our study demonstrates that administration of miR-181b could reduce atherosclerotic plaque vulnerability partially through modulating macrophage phenotype by directly targeting Notch1.

  15. Lead Poisoning

    MedlinePlus

    ... from lead poisoning in New Hampshire and in Alabama. Lead poisoning has also been associated with juvenile ... for decades—after it first enters the blood stream. (The same process can occur with the onset ...

  16. Lead poisoning

    MedlinePlus

    ... Failure at school Hearing problems Kidney damage Reduced IQ Slowed body growth The symptoms of lead poisoning ... can have a permanent impact on attention and IQ. People with higher lead levels have a greater ...

  17. PKC-dependent activation of human K2P18.1 K+ channels

    PubMed Central

    Rahm, Ann-Kathrin; Gierten, Jakob; Kisselbach, Jana; Staudacher, Ingo; Staudacher, Kathrin; Schweizer, Patrick A; Becker, Rüdiger; Katus, Hugo A; Thomas, Dierk

    2012-01-01

    BACKGROUND AND PURPOSE Two-pore-domain K+ channels (K2P) mediate K+ background currents that modulate the membrane potential of excitable cells. K2P18.1 (TWIK-related spinal cord K+ channel) provides hyperpolarizing background currents in neurons. Recently, a dominant-negative loss-of-function mutation in K2P18.1 has been implicated in migraine, and activation of K2P18.1 channels was proposed as a therapeutic strategy. Here we elucidated the molecular mechanisms underlying PKC-dependent activation of K2P18.1 currents. EXPERIMENTAL APPROACH Human K2P18.1 channels were heterologously expressed in Xenopus laevis oocytes, and currents were recorded with the two-electrode voltage clamp technique. KEY RESULTS Stimulation of PKC using phorbol 12-myristate-13-acetate (PMA) activated the hK2P18.1 current by 3.1-fold in a concentration-dependent fashion. The inactive analogue 4α-PMA had no effect on channel activity. The specific PKC inhibitors bisindolylmaleimide I, Ro-32-0432 and chelerythrine reduced PMA-induced channel activation indicating that PKC is involved in this effect of PMA. Selective activation of conventional PKC isoforms with thymeleatoxin (100 nM) did not reproduce K2P18.1 channel activation. Current activation by PMA was not affected by pretreatment with CsA (calcineurin inhibitor) or KT 5720 (PKA inhibitor), ruling out a significant contribution of calcineurin or cross-talk with PKA to the PKC-dependent hK2P18.1 activation. Finally, mutation of putative PKC phosphorylation sites did not prevent PMA-induced K2P18.1 channel activation. CONCLUSIONS AND IMPLICATIONS We demonstrated that activation of hK2P18.1 (TRESK) by PMA is mediated by PKC stimulation. Hence, PKC-mediated activation of K2P18.1 background currents may serve as a novel molecular target for migraine treatment. PMID:22168364

  18. Phase 1 Clinical Trials of DAS181, an Inhaled Sialidase, in Healthy Adults

    PubMed Central

    Zenilman, Jonathan M.; Fuchs, Edward J.; Hendrix, Craig W.; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U.; Hamilton, Robert G.; Griffiss, J. McLeod

    2015-01-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10 microns. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20 mg dose of DAS181, or placebo; the second, 20 mg DAS181 or placebo for 10 days, and the third got 20 mg of DAS181or placebo for 3 days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1 second) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration nos. NCT 00527865 and NCT 01651494.) PMID:26391974

  19. Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.

    PubMed

    Zenilman, Jonathan M; Fuchs, Edward J; Hendrix, Craig W; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U; Hamilton, Robert G; McLeod Griffiss, J

    2015-11-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10μm. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20mg dose of DAS181, or placebo; the second, 20mg DAS181 or placebo for 10days, and the third got 20mg of DAS181 or placebo for 3days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1s) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration Nos. NCT 00527865 and NCT 01651494.).

  20. Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice

    NASA Astrophysics Data System (ADS)

    Bai, Lihua; Guo, Jianxia; Clausen, Dana M.; Eiseman, Julie L.

    2010-02-01

    Objective: In in vitro photodynamic therapy, the LD50 of Pc 181 has been reported to be 7 to 8 times less than that of silicon phthalocyanine 4 (Pc 4). The Optical Pharmacokinetic System (OPS) can measure photosensitizer concentrations in accessible tissues non-invasively. We used OPS to evaluate the tumor pharmacokinetics of Pc 181 and Pc 4 and the tissue drug distribution in SCID mice bearing either human breast cancer MDA-MB-231 or human head and neck squamous cell carcinoma SCC-15 xenografts. Methods: Following iv administration of 2.5 mg/kg Pc 181 or 2 mg/kg Pc 4 to SCID mice, OPS measurements were taken on tumor and normal tissues between 5 and 4320 min in vivo or in situ. Results: Large variations in tumor Pc 181 concentrations were observed among mice. In MDA-MB-231 tumors, the Pc 181 concentration peaked at 240 min, and was retained in the tumor. Tumor Pc 181 concentrations were much less than the tumor Pc 4 concentrations at an equimolar dose. Pc 181 concentrations were the highest in liver, followed by spleen, and kidney. In mice bearing SCC-15 xenografts, skin and underlying tissue Pc 181 concentrations were higher than tumor concentrations at all time points examined. Conclusions: This first Pc 181 pharmacokinetics study described a tissue Pc 181 distribution similar to that of Pc 4. However, tumor Pc 181 concentrations were lower than those of Pc 4 at equimolar doses.