40 CFR 421.135 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N) .000 .000 (b... produced from smelting Antimony 5.038 2.245 Arsenic 3.628 1.488 Lead .731 .339 Zinc 2.662 1.096 Ammonia (as... refining Antimony .087 .039 Arsenic .063 .026 Lead .013 .006 Zinc .046 .019 Ammonia (as N) .000 .000 (d...

40 CFR 421.135 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N) .000 .000 (b... produced from smelting Antimony 5.038 2.245 Arsenic 3.628 1.488 Lead .731 .339 Zinc 2.662 1.096 Ammonia (as... refining Antimony .087 .039 Arsenic .063 .026 Lead .013 .006 Zinc .046 .019 Ammonia (as N) .000 .000 (d...

40 CFR 421.134 - Standards of performance for new sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... lead scrap produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N... Ammonia (as N) 0.000 0.000 Total suspended solids 39.150 31.320 pH (1) (1) 1 Within the range of 7.5 to 10... refining Antimony .000 .000 Arsenic .000 .000 Lead .000 .000 Zinc .000 .000 Ammonia (as N) .000 .000 Total...

40 CFR 421.134 - Standards of performance for new sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... lead scrap produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N... Ammonia (as N) 0.000 0.000 Total suspended solids 39.150 31.320 pH (1) (1) 1 Within the range of 7.5 to 10... refining Antimony .000 .000 Arsenic .000 .000 Lead .000 .000 Zinc .000 .000 Ammonia (as N) .000 .000 Total...

40 CFR 421.134 - Standards of performance for new sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... lead scrap produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N... Ammonia (as N) 0.000 0.000 Total suspended solids 39.150 31.320 pH (1) (1) 1 Within the range of 7.5 to 10... refining Antimony .000 .000 Arsenic .000 .000 Lead .000 .000 Zinc .000 .000 Ammonia (as N) .000 .000 Total...

40 CFR 421.134 - Standards of performance for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... lead scrap produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N... Ammonia (as N) 0.000 0.000 Total suspended solids 39.150 31.320 pH (1) (1) 1 Within the range of 7.5 to 10... refining Antimony .000 .000 Arsenic .000 .000 Lead .000 .000 Zinc .000 .000 Ammonia (as N) .000 .000 Total...

40 CFR 421.134 - Standards of performance for new sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... lead scrap produced Antimony 1.299 .579 Arsenic .936 .384 Lead .189 .087 Zinc .687 .283 Ammonia (as N... Ammonia (as N) 0.000 0.000 Total suspended solids 39.150 31.320 pH (1) (1) 1 Within the range of 7.5 to 10... refining Antimony .000 .000 Arsenic .000 .000 Lead .000 .000 Zinc .000 .000 Ammonia (as N) .000 .000 Total...

Development of km23-Based Diagnostics and Therapeutics

DTIC Science & Technology

2005-05-01

A107km23), instead of the wild-type 96-amino acid form of km23. Furthermore, five missense mutations (T381, S55G, T56S, 189V, and V90A) were detected in...acid form of 1um23. Furthermore, five TPR-I, and T41R-II can lead to disruption of TGF-P3-signaling missense mutations (T381, S55G, T56S, 189V, and V9OA...these alterations, the three other missense mutations detected (CKII) in km23. For these sites, the prediction scores for serine and in three other

Nuclear Data Sheets for A=189

DOE PAGES

Johnson, T. D.; Singh, Balraj

2017-04-26

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which aremore » pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.« less

Nuclear Data Sheets for A=189

NASA Astrophysics Data System (ADS)

Johnson, T. D.; Singh, Balraj

2017-05-01

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which are pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.

Nuclear Data Sheets for A=189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, T. D.; Singh, Balraj

Evaluated experimental data are presented for 13 known mass 189 nuclides (Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Po). Since the 2003Wu02 publication, structure and decay data from 25 new and primary publications have been incorporated in the current work, while adding a new 189Hf nuclide. New data have been added for all nuclides except 189Au and 189Hg. Moreover, several previous datasets were modified for β-decay Q values and conversion coefficients even when no new publications appeared since 2003Wu02. In spite of large amounts of data available for A=189 nuclides, several deficiencies remain, which aremore » pointed out below in the hope that further experimental work may improve our knowledge of structure of these nuclides. For 189Hf and 189Ta, ground-state half-lives, and their decay schemes are unknown. An isomer in 189Ta has recently been established but its decay characteristics are unknown, even though several gamma rays were connected with its decay. No excited states are known in 189W and only one in 189Po. The decay scheme of 189W is known poorly with most gamma rays left as unassigned. The decay schemes of 189Au and 189Pb g.s. suffer from incompleteness, while those for the g.s. and isomer of 189Tl are almost absent. The decay schemes of g.s. and isomer of 189Hg are very complex as apparent from the study by 1996Wo04. Evaluators feel that these two decay schemes could be improved with modern gamma-ray detector arrays. While several isomers are known in many of the A=189 nuclides, there is in general lack of information of level half-lives, thus limiting the knowledge of transition probabilities. High-spin structures, including SD bands in 189Hg and 189Tl, are known in 189Re, 189Ir, 189Pt, 189Au, 189Hg, 189Tl, 189Pb and 189Bi. Single-particle transfer data are available for 189Re, 189Os, and 189Pt; and two-neutron transfer data for 189Ir.« less

Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist

PubMed Central

Bu, Wei; Ren, Huiling; Deng, Yunping; Del Mar, Nobel; Guley, Natalie M.; Moore, Bob M.; Honig, Marcia G.; Reiner, Anton

2016-01-01

We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (CB2) receptors using 2-week daily administration of the CB2 inverse agonist SMM-189. CB2 inverse agonists stabilize the G-protein coupled CB2 receptor in an inactive conformation, leading to increased phosphorylation and nuclear translocation of the cAMP response element binding protein (CREB), and thus bias activated microglia from a pro-inflammatory M1 to a pro-healing M2 state. In the present study, we showed that SMM-189 boosts nuclear pCREB levels in microglia in several brain regions by 3 days after TBI, by using pCREB/CD68 double immunofluorescent labeling. Next, to better understand the basis of motor deficits and increased fearfulness after TBI, we used unbiased stereological methods to characterize neuronal loss in cortex, striatum, and basolateral amygdala (BLA) and assessed how neuronal loss was affected by SMM-189 treatment. Our stereological neuron counts revealed a 20% reduction in cortical and 30% reduction in striatal neurons bilaterally at 2–3 months post blast, with SMM-189 yielding about 50% rescue. Loss of BLA neurons was restricted to the blast side, with 33% of Thy1+ fear-suppressing pyramidal neurons and 47% of fear-suppressing parvalbuminergic (PARV) interneurons lost, and Thy1-negative fear-promoting pyramidal neurons not significantly affected. SMM-189 yielded 50–60% rescue of Thy1+ and PARV neuron loss in BLA. Thus, fearfulness after mild TBI may result from the loss of fear-suppressing neuron types in BLA, and SMM-189 may reduce fearfulness by their rescue. Overall, our findings indicate that SMM-189 rescues damaged neurons and thereby alleviates functional deficits resulting from TBI, apparently by selectively modulating microglia to the beneficial M2 state. CB2 inverse agonists thus represent a promising therapeutic approach for mitigating neuroinflammation and neurodegeneration. PMID:27766068

Proceedings of the Eighth Biennial Southern Silvicultural Research Conference

Treesearch

M. Boyd Edwards

1995-01-01

These proceedings represents the research of 189 investigators studying the patterns and processes of managed southern forests through 104 reported studies. These contributions emanate from scientists located at various universities, forestry industries, and public agencies. Their approaches and findings lead the way to efficient and wise management of our nation’ s...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Trademark Cases §§ 2.188-2.189 [Reserved] ...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.25-30 - Electrical engineering equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Electrical engineering equipment. 189.25-30 Section 189... VESSELS INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-30 Electrical engineering equipment. (a) For inspection procedures of Electrical Engineering equipment and systems, see Subchapter J...

46 CFR 189.60-1 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 189.60-1 Section 189.60-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-1 Application...

46 CFR 189.35-1 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 189.35-1 Section 189.35-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Weight Handling Gear § 189.35-1 Application. (a) The requirements of this subpart shall apply to...

27 CFR 19.189 - Identification of structures, areas, apparatus, and equipment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... structures, areas, apparatus, and equipment. 19.189 Section 19.189 Alcohol, Tobacco Products and Firearms... Construction, Equipment, and Security Requirements Other Plant Requirements § 19.189 Identification of structures, areas, apparatus, and equipment. (a) Buildings. The proprietor must mark each building at a...

Tennessee's timber industry-an assessment of timber product output and use, 2005

Treesearch

James W. Bentley; Doug Schnabel

2007-01-01

In 2005, roundwood output from Tennessee’s forests was 325 million cubic feet. Mill byproducts generated from primary manufacturers totaled 119 million cubic feet. Seventy-three percent of the plant residues were used primarily for fuel and fiber products. Saw logs were the leading roundwood product at 189 million cubic feet; pulpwood ranked second at 121 million cubic...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Master's responsibility. 189.35-13 Section 189.35-13... AND CERTIFICATION Weight Handling Gear § 189.35-13 Master's responsibility. (a) The master of the... permitted to operate the weight handling gear. The master shall designate the operators. (5) A minimum...

46 CFR 189.35-7 - Examinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Examinations. 189.35-7 Section 189.35-7 Shipping COAST... CERTIFICATION Weight Handling Gear § 189.35-7 Examinations. (a) Examination of weight handling gear will normally consist of a visual examination with access covers removed. Suitability of the equipment for the...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.25-47 - Chemical and explosive hazards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Chemical and explosive hazards. 189.25-47 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-47 Chemical and explosive hazards. (a) The marine inspector shall inspect every chemistry laboratory, scientific laboratory, and chemical storeroom...

46 CFR 189.20-25 - Chemical and explosive hazards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Chemical and explosive hazards. 189.20-25 Section 189.20-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-25 Chemical and explosive hazards. (a) If installed...

46 CFR 189.25-25 - Hull equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Hull equipment. 189.25-25 Section 189.25-25 Shipping... CERTIFICATION Inspection for Certification § 189.25-25 Hull equipment. (a) At each inspection for certification and periodic inspection the inspector shall conduct the following tests and inspections of hull...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

46 CFR 189.25-35 - Marine engineering equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Marine engineering equipment. 189.25-35 Section 189.25... INSPECTION AND CERTIFICATION Inspection for Certification § 189.25-35 Marine engineering equipment. (a) For inspection procedures of Marine Engineering equipment and systems, see Subchapter F (Marine Engineering) of...

49 CFR 37.189 - Service requirement for OTRB demand-responsive systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Service requirement for OTRB demand-responsive systems. 37.189 Section 37.189 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.189 Service requirement...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

10 CFR 26.189 - Determination of fitness.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Determination of fitness. 26.189 Section 26.189 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.189 Determination of fitness. (a) A determination of fitness is the process entered...

10 CFR 26.189 - Determination of fitness.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Determination of fitness. 26.189 Section 26.189 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Determining Fitness-for-Duty Policy Violations and Determining Fitness § 26.189 Determination of fitness. (a) A determination of fitness is the process entered...

46 CFR 189.20-10 - Plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Plans. 189.20-10 Section 189.20-10 Shipping COAST GUARD... Initial Inspection § 189.20-10 Plans. (a) Before application for inspection is made, and before construction is started, the owner or builder shall have plans approved by the Commandant indicating the...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

46 CFR 189.25-38 - Pollution prevention.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Pollution prevention. 189.25-38 Section 189.25-38... AND CERTIFICATION Inspection for Certification § 189.25-38 Pollution prevention. At each inspection... meets the vessel design and equipment requirements for pollution prevention in 33 CFR part 155, subpart...

Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure.

PubMed

Pudney, Christopher R; McGrory, Tom; Lafite, Pierre; Pang, Jiayun; Hay, Sam; Leys, David; Sutcliffe, Michael J; Scrutton, Nigel S

2009-05-25

Mutation of an active-site residue in morphinone reductase leads to a conformationally rich landscape that enhances the rate of hydride transfer from NADH to FMN at standard pressure (1 bar). Increasing the pressure causes interconversion between different conformational substates in the mutant enzyme. While high pressure reduces the donor-acceptor distance in the wild-type enzyme, increased conformational freedom "dampens" its effect in the mutant.We show that hydride transfer from NADH to FMN catalysed by the N189A mutant of morphinone reductase occurs along parallel "chemical" pathways in a conformationally rich free-energy landscape. We have developed experimental kinetic and spectroscopic tools by using hydrostatic pressure to explore this free-energy landscape. The crystal structure of the N189A mutant enzyme in complex with the unreactive coenzyme analogue NADH(4) indicates that the nicotinamide moiety of the analogue is conformationally less restrained than the corresponding structure of the wild-type NADH(4) complex. This increased degree of conformational freedom in the N189A enzyme gives rise to the concept of multiple reactive configurations (MRCs), and we show that the relative population of these states across the free-energy landscape can be perturbed experimentally as a function of pressure. Specifically, the amplitudes of individual kinetic phases that were observed in stopped-flow studies of the hydride transfer reaction are sensitive to pressure; this indicates that pressure drives an altered distribution across the energy landscape. We show by absorbance spectroscopy that the loss of charge-transfer character of the enzyme-coenzyme complex is attributed to the altered population of MRCs on the landscape. The existence of a conformationally rich landscape in the N189A mutant is supported by molecular dynamics simulations at low and high pressure. The work provides firm experimental and computational support for the existence of parallel pathways arising from multiple conformational states of the enzyme-coenzyme complex. Hydrostatic pressure is a powerful and general probe of multidimensional energy landscapes that can be used to analyse experimentally parallel pathways for enzyme-catalysed reactions. We suggest that this is especially the case following directed mutation of a protein, which can lead to increased population of reactant states that are essentially inaccessible in the free-energy landscape of wild-type enzyme.

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Certificates § 21.189 Issue of airworthiness certificate for limited category aircraft. (a) An applicant for an...

46 CFR 189.20-20 - Specific tests and inspections.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Specific tests and inspections. 189.20-20 Section 189.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-20 Specific tests and inspections. The applicable tests and inspections as set forth in...

46 CFR 189.20-20 - Specific tests and inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Specific tests and inspections. 189.20-20 Section 189.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 189.20-20 Specific tests and inspections. The applicable tests and inspections as set forth in...

15 CFR 18.9 - Awards against other agencies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Awards against other agencies. 18.9 Section 18.9 Commerce and Foreign Trade Office of the Secretary of Commerce ATTORNEY'S FEES AND OTHER EXPENSES General Provisions § 18.9 Awards against other agencies. If an applicant is entitled to an award...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General Provisions § 189.1 Substances prohibited...

46 CFR 189.55-20 - Number of plans required.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Number of plans required. 189.55-20 Section 189.55-20... AND CERTIFICATION Plan Approval § 189.55-20 Number of plans required. (a) Three copies of each plan... additional approved plans, a suitable number should be submitted to permit the required distribution. [CGFR...

46 CFR 189.55-20 - Number of plans required.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Number of plans required. 189.55-20 Section 189.55-20... AND CERTIFICATION Plan Approval § 189.55-20 Number of plans required. (a) Three copies of each plan... additional approved plans, a suitable number should be submitted to permit the required distribution. [CGFR...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Addition to Human Food Through Food-Contact Surfaces § 189.220 Flectol H. (a) Flectol H is the chemical 1,2...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.30-1 - General or partial survey.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false General or partial survey. 189.30-1 Section 189.30-1... AND CERTIFICATION Inspection After Accident § 189.30-1 General or partial survey. (a) A survey, either... made. The survey shall be such as to insure that the necessary repairs or renewals have been...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10 Section 189.60-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-10 Cargo Ship Safety...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5 Section 189.60-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-5 Cargo Ship Safety...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section 189.60-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Certificates Under International Convention for Safety of Life at Sea, 1974 § 189.60-15 Cargo Ship Safety Radio...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.35-5 - Tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Tests. 189.35-5 Section 189.35-5 Shipping COAST GUARD... Weight Handling Gear § 189.35-5 Tests. (a) An installation load test and safety assessment shall be..., of the time and place of the installation tests when occurring in a port of the United States to...

46 CFR 189.25-45 - Fire hazards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Fire hazards. 189.25-45 Section 189.25-45 Shipping COAST... CERTIFICATION Inspection for Certification § 189.25-45 Fire hazards. At each inspection for certification and... that there is no accumulation of oil which might create a fire hazard. [CGFR 67-83, 33 FR 1118, Jan. 27...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Monochloroacetic acid. 189.155 Section 189.155... Prohibited From Direct Addition or Use as Human Food § 189.155 Monochloroacetic acid. (a) Monochloroacetic acid is the chemical chloroacetic acid, C2H3C1O2. It is a synthetic chemical not found in natural...

40 CFR 421.302 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Chlorination off-gas wet air pollution control. BPT Limitations for the Primary and Secondary Titanium... per million pounds) of TiCl4 produced Chromium (total) 0.412 0.168 Lead 0.393 0.187 Nickel 1.797 1.189... Within the range of 7.5 to 10.0 at all times. (b) Chlorination area-vent wet air pollution control. BPT...

40 CFR 421.302 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Chlorination off-gas wet air pollution control. BPT Limitations for the Primary and Secondary Titanium... per million pounds) of TiCl4 produced Chromium (total) 0.412 0.168 Lead 0.393 0.187 Nickel 1.797 1.189... Within the range of 7.5 to 10.0 at all times. (b) Chlorination area-vent wet air pollution control. BPT...

Generalized environmental control and life support system computer program (G189A) configuration control, phase 2

NASA Technical Reports Server (NTRS)

Mcenulty, R. E.

1977-01-01

The G189A simulation of the Shuttle Orbiter ECLSS was upgraded. All simulation library versions and simulation models were converted from the EXEC2 to the EXEC8 computer system and a new program, G189PL, was added to the combination master program library. The program permits the post-plotting of up to 100 frames of plot data over any time interval of a G189 simulation run. The overlay structure of the G189A simulations were restructured for the purpose of conserving computer core requirements and minimizing run time requirements.

Twitter Social Media is an Effective Tool for Breast Cancer Patient Education and Support: Patient-Reported Outcomes by Survey.

PubMed

Attai, Deanna J; Cowher, Michael S; Al-Hamadani, Mohammed; Schoger, Jody M; Staley, Alicia C; Landercasper, Jeffrey

2015-07-30

Despite reported benefits, many women do not attend breast cancer support groups. Abundant online resources for support exist, but information regarding the effectiveness of participation is lacking. We report the results of a Twitter breast cancer support community participant survey. The aim was to determine the effectiveness of social media as a tool for breast cancer patient education and decreasing anxiety. The Breast Cancer Social Media Twitter support community (#BCSM) began in July 2011. Institutional review board approval with a waiver of informed consent was obtained for a deidentified survey that was posted for 2 weeks on Twitter and on the #BCSM blog and Facebook page. There were 206 respondents to the survey. In all, 92.7% (191/206) were female. Respondents reported increased knowledge about breast cancer in the following domains: overall knowledge (80.9%, 153/189), survivorship (85.7%, 162/189), metastatic breast cancer (79.4%, 150/189), cancer types and biology (70.9%, 134/189), clinical trials and research (66.1%, 125/189), treatment options (55.6%, 105/189), breast imaging (56.6%, 107/189), genetic testing and risk assessment (53.9%, 102/189), and radiotherapy (43.4%, 82/189). Participation led 31.2% (59/189) to seek a second opinion or bring additional information to the attention of their treatment team and 71.9% (136/189) reported plans to increase their outreach and advocacy efforts as a result of participation. Levels of reported anxiety before and after participation were analyzed: 29 of 43 (67%) patients who initially reported "high or extreme" anxiety reported "low or no" anxiety after participation (P<.001). Also, no patients initially reporting low or no anxiety before participation reported an increase to high or extreme anxiety after participation. This study demonstrates that breast cancer patients' perceived knowledge increases and their anxiety decreases by participation in a Twitter social media support group.

Airway clearance techniques in acute exacerbations of COPD: a survey of Australian physiotherapy practice.

PubMed

Osadnik, Christian R; McDonald, Christine F; Holland, Anne E

2013-06-01

To identify airway clearance techniques (ACTs) used to treat patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and identify factors underpinning their utilisation, including therapists' knowledge of the literature. Cross-sectional postal survey using Likert scales and multiple-choice responses. 112 'large' or 'principal referral' Australian public hospitals. 189 physiotherapists from 89 hospitals (response rate 81%). Purpose designed survey measuring self-reported rate of ACT prescription; perception of ACT indications, aims, importance and effectiveness; factors influencing ACT choice; and knowledge of the evidence. Most physiotherapists (123/189, 65%) prescribed ACTs for 60-100% of patients with AECOPDs. The most frequently prescribed ACTs were physical exercise (169/189, 89%), the forced expiratory technique (153/189, 81%) and the active cycle of breathing technique (149/189, 79%). Most were rated highly effective. Physiotherapists who perceived the role of ACTs to be important to patients' overall management (137/189, 73%) and those with less than 5 years cardiorespiratory experience (113/189, 60%) prescribed ACTs significantly more frequently than others. The main factors influencing ACT choice were precautions/contraindications to individual techniques (148/189, 78%) and degree of dyspnoea (136/189, 72%). The primary aim of ACT prescription was to clear sputum (178/189, 94%). Understanding of the evidence for ACTs in AECOPDs was mixed, with 43% citing it as supportive, 30% inconclusive and 19% unsure. Australian physiotherapists frequently prescribe ACTs for patients with AECOPDs and perceive their role to be important. Physical exercise is frequently prescribed for airway clearance and warrants further investigation. Copyright © 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Inactivation of DNA-Binding Response Regulator Sak189 Abrogates β-Antigen Expression and Affects Virulence of Streptococcus agalactiae

PubMed Central

Rozhdestvenskaya, Anastasia S.; Totolian, Artem A.; Dmitriev, Alexander V.

2010-01-01

Background Streptococcus agalactiae is able to colonize numerous tissues employing different mechanisms of gene regulation, particularly via two-component regulatory systems. These systems sense the environmental stimuli and regulate expression of the genes including virulence genes. Recently, the novel two-component regulatory system Sak188/Sak189 was identified. In S. agalactiae genome, it was adjacent to the bac gene encoding for β-antigen, an important virulence factor. Methodology/Principal Findings In this study, the sak188 and sak189 genes were inactivated, and the functional role of Sak188/Sak189 two-component system in regulation of the β-antigen expression was investigated. It was demonstrated that both transcription of bac gene and expression of encoded β-antigen were controlled by Sak189 response regulator, but not Sak188 histidine kinase. It was also found that the regulation occurred at transcriptional level. Finally, insertional inactivation of sak189 gene, but not sak188 gene, significantly affected virulent properties of S. agalactiae. Conclusions/Significance Sak189 response regulator is necessary for activation of bac gene transcription. It also controls the virulent properties of S. agalactiae. Given that the primary functional role of Sak188/Sak189 two-component systems is a control of bac gene transcription, this system can be annotated as BgrR/S (bac gene regulatory system). PMID:20419089

No Evidence from FTIR Difference Spectroscopy that Glutamate-189 of the D1 Polypeptide Ligates a Mn Ion that Undergoes Oxidation During the S0 to S1, S1 to S2, or S2 to S3 Transitions in Photosystem II†

PubMed Central

Strickler, Melodie A.; Hillier, Warwick; Debus, Richard J.

2008-01-01

In the recent X-ray crystallographic structural models of photosystem II, Glu189 of the D1 polypeptide is assigned as a ligand of the oxygen-evolving Mn4 cluster. To determine if D1-Glu189 ligates a Mn ion that undergoes oxidation during one or more of the S0 → S1, S1 → S2, and S2 → S3 transitions, the FTIR difference spectra of the individual S state transitions in D1-E189Q and D1-E189R mutant PSII particles from the cyanobacterium Synechocystis sp. PCC 6803 were compared with those in wild-type PSII particles. Remarkably, the data show that neither mutation significantly alters the mid-frequency regions (1800 − 1200 cm−1) of any of the FTIR difference spectra. Importantly, neither mutation eliminates any specific symmetric or asymmetric carboxylate stretching mode that might have been assigned to D1-Glu189. The small spectral alterations that are observed are similar in amplitude to those that are observed in wild-type PSII particles that have been exchanged into FTIR analysis buffer by different methods or those that are observed in D2-H189Q mutant PSII particles (the residue D2-His189 is located > 25 Å from the Mn4 cluster and accepts a hydrogen bond from Tyr YD). The absence of significant mutation-induced spectral alterations in the D1-Glu189 mutants shows that the oxidation of the Mn4 cluster does not alter the frequencies of the carboxylate stretching modes of D1-Glu189 during the S0 → S1, S1 → S2, or S2 → S3 transitions. One explanation of these data is that D1-Glu189 ligates a Mn ion that does not increase its charge or oxidation state during any of these S state transitions. However, because the same conclusion was reached previously for D1-Asp170, and because the recent X-ray crystallographic structural models assign D1-Asp170 and D1-Glu189 as ligating different Mn ions, this explanation requires that (1) the extra positive charge that develops on the Mn4 cluster during the S1 → S2 transition be localized on the Mn ion that is ligated by the α-COO− group of D1-Ala344 and (2) any increase in positive charge that develops on the Mn4 cluster during the S0 → S1 and S2 → S3 transitions be localized on the one Mn ion that is not ligated by D1-Asp170, D1-Glu189, or D1-Ala344. An alternative explanation of the FTIR data is that D1-Glu189 does not ligate the Mn4 cluster. This conclusion would be consistent with earlier spectroscopic analyses of D1-Glu189 mutants, but would require that the proximity of D1-Glu189 to manganese in the X-ray crystallographic structural models be an artifact of the radiation-induced reduction of the Mn4 cluster that occurred during the collection of the X-ray diffraction data. PMID:16846223

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.138-4288.189 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false [Reserved] 4288.138-4288.189 Section 4288.138-4288.189 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

Design and installation of a subsea multiwell drilling template at Garden Banks Block 189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domangue, R.J.

1991-09-01

This paper describes the economics, design, and installation of a simple drilling template that was used to retain or save subsea exploratory and delineation wells in Garden Banks Block 189 (GB 189) in the Gulf of Mexico.

46 CFR 189.35-13 - Master's responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Master's responsibility. 189.35-13 Section 189.35-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION... appropriate showing such items as inspections, tests, important repairs and casualties experienced. This...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

22 CFR 18.9 - Contents of complaint.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Contents of complaint. 18.9 Section 18.9 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF... against the respondent in the event he/she fails to file an answer. ...

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Safrole. 189.180 Section 189.180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.113 - Cinnamyl anthranilate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cinnamyl anthranilate. 189.113 Section 189.113 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189.165 Nordihydroguaiaretic acid (NDGA...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.190 - Thiourea.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Thiourea. 189.190 Section 189.190 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally...

Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist

PubMed Central

Presley, Chaela; Abidi, Ammaar; Suryawanshi, Satyendra; Mustafa, Suni; Meibohm, Bernd; Moore, Bob M

2015-01-01

Cannabinoid receptor 2 agonists and inverse agonists are emerging as new therapeutic options for a spectrum of autoimmune-related disease. Of particular interest, is the ability of CB2 ligands to regulate microglia function in neurodegenerative diseases and traumatic brain injury. We have previously reported the receptor affinity of 3′,5′-dichloro-2,6-dihydroxy-biphenyl-4-yl)-phenyl-methanone (SMM-189) and the characterization of the beneficial effects of SMM-189 in the mouse model of mild traumatic brain injury. Herein, we report the further characterization of SMM-189 as a potent and selective CB2 inverse agonist, which acts as a noncompetitive inhibitor of CP 55,940. The ability of SMM-189 to regulate microglial activation, in terms of chemokine expression and cell morphology, has been determined. Finally, we have determined that SMM-189 possesses acceptable biopharmaceutical properties indicating that the triaryl class of CB2 inverse agonists are viable compounds for continued preclinical development for the treatment of neurodegenerative disorders and traumatic brain injury. PMID:26196013

Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.

PubMed

Presley, Chaela; Abidi, Ammaar; Suryawanshi, Satyendra; Mustafa, Suni; Meibohm, Bernd; Moore, Bob M

2015-08-01

Cannabinoid receptor 2 agonists and inverse agonists are emerging as new therapeutic options for a spectrum of autoimmune-related disease. Of particular interest, is the ability of CB2 ligands to regulate microglia function in neurodegenerative diseases and traumatic brain injury. We have previously reported the receptor affinity of 3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-phenyl-methanone (SMM-189) and the characterization of the beneficial effects of SMM-189 in the mouse model of mild traumatic brain injury. Herein, we report the further characterization of SMM-189 as a potent and selective CB2 inverse agonist, which acts as a noncompetitive inhibitor of CP 55,940. The ability of SMM-189 to regulate microglial activation, in terms of chemokine expression and cell morphology, has been determined. Finally, we have determined that SMM-189 possesses acceptable biopharmaceutical properties indicating that the triaryl class of CB2 inverse agonists are viable compounds for continued preclinical development for the treatment of neurodegenerative disorders and traumatic brain injury.

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.250 - Mercaptoimidazoline and 2-mercaptoimidazoline.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Mercaptoimidazoline and 2-mercaptoimidazoline. 189.250 Section 189.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight instructor records. 61.189 Section...) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors Other than Flight Instructors With a Sport Pilot Rating § 61.189 Flight instructor records. (a) A flight instructor...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Flight instructor records. 61.189 Section...) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS Flight Instructors Other than Flight Instructors With a Sport Pilot Rating § 61.189 Flight instructor records. (a) A flight instructor...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Flight instructor records. 61.189 Section 61.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... person that instructor has endorsed for a knowledge test or practical test, and the record shall also...

14 CFR 61.189 - Flight instructor records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight instructor records. 61.189 Section 61.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... person that instructor has endorsed for a knowledge test or practical test, and the record shall also...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false P-4000. 189.175 Section 189.175 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

30 CFR 18.9 - Conduct of investigations and tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Conduct of investigations and tests. 18.9 Section 18.9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES General...

46 CFR 189.45-5 - Inspection required.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Inspection required. 189.45-5 Section 189.45-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... partial depending upon the circumstances, shall be made whenever any important repairs or alterations are...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... a condition for safe operation. (b) The Administrator prescribes limitations and conditions...

14 CFR 21.189 - Issue of airworthiness certificate for limited category aircraft.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Issue of airworthiness certificate for limited category aircraft. 21.189 Section 21.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... a condition for safe operation. (b) The Administrator prescribes limitations and conditions...

37 CFR 2.188-2.189 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false [Reserved] 2.188-2.189 Section 2.188-2.189 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES General Information and Correspondence in...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.140 - Diethylpyrocarbonate (DEPC).

Code of Federal Regulations, 2010 CFR

2010-04-01

... alcoholic and nonalcoholic beverages. (b) Food containing any added or detectable level of DEPC is deemed to... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Diethylpyrocarbonate (DEPC). 189.140 Section 189.140 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Skim milk cheese for manufacturing. 133.189... (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.189 Skim milk cheese for manufacturing. (a) Skim milk cheese for...

14 CFR 125.189 - Demonstration of emergency evacuation procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the emergency evacuation procedures for each type and model of airplane with a seating of more than 44... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Demonstration of emergency evacuation procedures. 125.189 Section 125.189 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 2 2011-04-01 2011-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 2 2012-04-01 2012-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

25 CFR 700.189 - Expenditure of replacement home benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Expenditure of replacement home benefits. 700.189 Section... PROCEDURES Replacement Housing Payments § 700.189 Expenditure of replacement home benefits. Replacement home... maximum replacement home benefit. (b) All replacement home benefits shall be expended not later than one...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

21 CFR 189.135 - Cyclamate and its derivatives.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Cyclamate and its derivatives. 189.135 Section 189.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

46 CFR 189.40-1 - Definitions relating to hull examinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Definitions relating to hull examinations. 189.40-1 Section 189.40-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... fuel oil tanks. (c) Underwater survey means the examination, while the vessel is afloat, of all...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2014 CFR

2014-04-01

... component of food packaging adhesives. (b) Food containing any added or detectable level of this substance... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED...

Evaluating predictors of lead exposure for activities disturbing materials painted with or containing lead using historic published data from U.S. workplaces.

PubMed

Locke, Sarah J; Deziel, Nicole C; Koh, Dong-Hee; Graubard, Barry I; Purdue, Mark P; Friesen, Melissa C

2017-02-01

We evaluated predictors of differences in published occupational lead concentrations for activities disturbing material painted with or containing lead in U.S. workplaces to aid historical exposure reconstruction. For the aforementioned tasks, 221 air and 113 blood lead summary results (1960-2010) were extracted from a previously developed database. Differences in the natural log-transformed geometric mean (GM) for year, industry, job, and other ancillary variables were evaluated in meta-regression models that weighted each summary result by its inverse variance and sample size. Air and blood lead GMs declined 5%/year and 6%/year, respectively, in most industries. Exposure contrast in the GMs across the nine jobs and five industries was higher based on air versus blood concentrations. For welding activities, blood lead GMs were 1.7 times higher in worst-case versus non-worst case scenarios. Job, industry, and time-specific exposure differences were identified; other determinants were too sparse or collinear to characterize. Am. J. Ind. Med. 60:189-197, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances...

38 CFR 18.9 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Hearings. 18.9 Section 18... THE CIVIL RIGHTS ACT OF 1964 General § 18.9 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 18.8(c), reasonable notice shall be given by registered or...

21 CFR 189.120 - Cobaltous salts and its derivatives.

Code of Federal Regulations, 2010 CFR

2010-04-01

... malt beverages as a foam stabilizer and to prevent “gushing.” (b) Food containing any added cobaltous... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Cobaltous salts and its derivatives. 189.120 Section 189.120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2011 CFR

2011-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

34 CFR 668.189 - General requirements for adjusting official cohort default rates and for appealing their...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false General requirements for adjusting official cohort default rates and for appealing their consequences. 668.189 Section 668.189 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF...

18 CFR 367.1890 - Account 189, Unamortized loss on reacquired debt.

Code of Federal Regulations, 2010 CFR

2010-04-01

... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Deferred Debits § 367.1890 Account 189... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 189, Unamortized loss on reacquired debt. 367.1890 Section 367.1890 Conservation of Power and Water Resources...

25 CFR 900.189 - Does this coverage extend to subcontractors of self-determination contracts?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Does this coverage extend to subcontractors of self-determination contracts? 900.189 Section 900.189 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... this coverage extend to subcontractors of self-determination contracts? No. Subcontractors or...

38 CFR 18.9 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Hearings. 18.9 Section 18... THE CIVIL RIGHTS ACT OF 1964 General § 18.9 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 18.8(c), reasonable notice shall be given by registered or...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.165 - Nordihydroguaiaretic acid (NDGA).

Code of Federal Regulations, 2014 CFR

2014-04-01

... method used for detecting NDGA in food is in section 20.008(b) of the “Official Methods of Analysis of... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Nordihydroguaiaretic acid (NDGA). 189.165 Section 189.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.155 - Monochloroacetic acid.

Code of Federal Regulations, 2014 CFR

2014-04-01

... monochloroacetic acid in food are in sections 20.067-20.072 of the “Official Methods of Analysis of the Association... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Monochloroacetic acid. 189.155 Section 189.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... detecting coumarin in food are in sections 19.016-19.024 of the “Official Methods of Analysis of the... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Coumarin. 189.130 Section 189.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-5 - Cargo Ship Safety Construction Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Construction Certificate. 189.60-5..., 1974 § 189.60-5 Cargo Ship Safety Construction Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Construction Certificate. This certificate shall be issued by...

46 CFR 189.60-15 - Cargo Ship Safety Radio Certificate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Cargo Ship Safety Radio Certificate. 189.60-15 Section..., 1974 § 189.60-15 Cargo Ship Safety Radio Certificate. Every vessel equipped with a radio installation on an international voyage must have a Cargo Ship Safety Radio Certificate. Each radio installation...

46 CFR 189.60-10 - Cargo Ship Safety Equipment Certificate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Cargo Ship Safety Equipment Certificate. 189.60-10..., 1974 § 189.60-10 Cargo Ship Safety Equipment Certificate. (a) All vessels on an international voyage are required to have a Cargo Ship Safety Equipment Certificate. (b) All such vessels shall meet the...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2014 CFR

2014-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2010 CFR

2010-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2011 CFR

2011-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2013 CFR

2013-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

46 CFR 189.40-3 - Drydock examination, internal structural examination, cargo tank internal examination, and...

Code of Federal Regulations, 2012 CFR

2012-10-01

..., cargo tank internal examination, and underwater survey intervals. 189.40-3 Section 189.40-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND... examination, and underwater survey intervals. (a) Except as provided for in paragraphs (b) through (g) of this...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.1 - Substances prohibited from use in human food.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Substances prohibited from use in human food. 189.1 Section 189.1 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD General...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2012 CFR

2012-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.220 - Flectol H.

Code of Federal Regulations, 2013 CFR

2013-04-01

... products, and has been used as a component of food packaging adhesives. (b) Food containing any added or... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Flectol H. 189.220 Section 189.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

21 CFR 189.120 - Cobaltous salts and its derivatives.

Code of Federal Regulations, 2011 CFR

2011-04-01

... malt beverages as a foam stabilizer and to prevent “gushing.” (b) Food containing any added cobaltous... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Cobaltous salts and its derivatives. 189.120 Section 189.120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

Photosynthetic water oxidation in Synechocystis sp. PCC6803: mutations D1-E189K, R and Q are without influence on electron transfer at the donor side of photosystem II.

PubMed

Clausen, J; Winkler, S; Hays, A M; Hundelt, M; Debus, R J; Junge, W

2001-11-01

The oxygen-evolving manganese cluster (OEC) of photosynthesis is oxidised by the photochemically generated primary oxidant (P(+*)(680)) of photosystem II via a tyrosine residue (Y(Z), Tyr161 on the D1 subunit of Synechocystis sp. PCC6803). The redox span between these components is rather small and probably tuned by protonic equilibria. The very efficient electron transfer from Y(Z) to P(+*)(680) in nanoseconds requires the intactness of a hydrogen bonded network involving Y(Z), D1-His190, and presumably D1-Glu189. We studied photosystem II core particles from photoautotrophic mutants where the residue D1-E189 was replaced by glutamine, arginine and lysine which were expected to electrostatically differ from the glutamate in the wild-type (WT). Surprisingly, the rates of electron transfer from Y(Z) to P(+*)(680) as well as from the OEC to Y(ox)(Z) were the same as in the WT. With the generally assumed proximity between D1-His190 (and thus D1-Glu189) and Y(Z), the lack of any influence on the electron transfer around Y(Z) straightforwardly implies a strongly hydrophobic environment forcing Glu (acid) and Lys, Arg (basic) at position D1-189 into electro-neutrality. As one alternative, D1-Glu189 could be located at such a large distance from the OEC, Y(Z) and P(+*)(680) that a charge on D1-189X does not influence the electron transfer. This seems less likely in the light of the drastic influence of its direct neighbour, D1-His190, on Y(Z) function. Another alternative is that D1-Glu189 is negatively charged, but is located in a cluster of acid/base groups that compensates for an alteration of charge at position 189, leaving the overall net charge unchanged in the Gln, Lys, and Arg mutants.

Generalized environmental control and life support system computer program (G189A) configuration control. [computer subroutine libraries for shuttle orbiter analyses

NASA Technical Reports Server (NTRS)

Blakely, R. L.

1973-01-01

A G189A simulation of the shuttle orbiter EC/lSS was prepared and used to study payload support capabilities. Two master program libraries of the G189A computer program were prepared for the NASA/JSC computer system. Several new component subroutines were added to the G189A program library and many existing subroutines were revised to improve their capabilities. A number of special analyses were performed in support of a NASA/JSC shuttle orbiter EC/LSS payload support capability study.

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2014 CFR

2014-04-01

... manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added or detectable levels of... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

...), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a) and 192(b... further progress or attainment). Design concept means the type of facility identified by the project, e.g... capacity and control, e.g., number of lanes or tracks to be constructed or added, length of project...

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

...(c)(2)(A), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a... project, e.g., freeway, expressway, arterial highway, grade-separated highway, reserved right-of-way rail... person carrying capacity and control, e.g., number of lanes or tracks to be constructed or added, length...

40 CFR 93.101 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

...), 182(c)(2)(B), 187(a)(7), 187(g), 189(a)(1)(B), 189(b)(1)(A), and 189(d); sections 192(a) and 192(b... further progress or attainment). Design concept means the type of facility identified by the project, e.g... capacity and control, e.g., number of lanes or tracks to be constructed or added, length of project...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2011 CFR

2011-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2011-04-01 2011-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2014 CFR

2014-04-01

... natural products and has been used as a polyurethane curing agent and as a component of food packaging... 21 Food and Drugs 3 2014-04-01 2014-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2013 CFR

2013-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2013-04-01 2013-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 189.280 - 4,4′-Methylenebis (2-chloro-analine).

Code of Federal Regulations, 2012 CFR

2012-04-01

... component of food packaging adhesives and polyurethane resins. (b) Food containing any added or detectable... 21 Food and Drugs 3 2012-04-01 2012-04-01 false 4,4â²-Methylenebis (2-chloro-analine). 189.280 Section 189.280 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (d) For the purposes of this section, “skim milk” means cow's milk from which the milk fat has been... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Skim milk cheese for manufacturing. 133.189... Standardized Cheese and Related Products § 133.189 Skim milk cheese for manufacturing. (a) Skim milk cheese for...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2012 CFR

2012-04-01

... resins are used in the manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

21 CFR 189.300 - Hydrogenated 4,4′-isopropyl-idene-diphenol-phosphite ester resins.

Code of Federal Regulations, 2013 CFR

2013-04-01

... resins are used in the manufacture of rigid vinyl chloride polymer bottles. (b) Food containing any added... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Hydrogenated 4,4â²-isopropyl-idene-diphenol-phosphite ester resins. 189.300 Section 189.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

Anti-inflammatory activity of cannabinoid receptor 2 ligands in primary hPDL fibroblasts.

PubMed

Abidi, Ammaar H; Presley, Chaela S; Dabbous, Mustafa; Tipton, David A; Mustafa, Suni M; Moore, Bob M

2018-03-01

Approximately 65 million adults in the US have periodontitis, causing tooth loss and decreased quality of life. Cannabinoids modulate immune responses, and endocannabinoids are prevalent during oral cavity inflammation. Targets for intervention in periodontal inflammation are cannabinoid type 1 and 2 receptors (CB1R, CB2R), particularly CB2R because its levels increase during inflammation. We previously demonstrated that SMM-189 (CB2R inverse agonist) decreased pro-inflammatory cytokine production in primary microglial cells. The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-α, or IL-1β. Cytotoxic effects of cannabinoid compounds (10 -4 -10 -6.5  M), LPS (1-1000 ng/ml), TNFα (10 ng/ml) and IL-1β (1 ng/ml) were assessed by measuring effects on cellular dehydrogenase activity. IL-6 and MCP-1 production were measured using Mesoscale Discovery (MSD) Human Pro-Inflammatory IL-6 and MSD Human Chemokine MCP-1 kits and analyzed using MSD Sector 2400 machine. EC 50 values for AEA, SMM-189, and HU-308 were 16 μM, 13 μM, and 7.3 μM respectively. LPS (1 μg/ml), TNF-α (10 ng/ml), and IL-1β (1 ng/ml) increased IL-6 and MCP-1 production, which were inhibited by AEA, SMM-189, and HU-308. AEA alone significantly increased IL-6, but not MCP-1 levels, but the other cannabinoids alone had no effect. The effective inhibition of LPS, TNF-α, IL-1β stimulated IL-6 and MCP-1 production by CB2R ligands in hPDLFs suggests that targeting the endocannabinoid system may lead to development of novel drugs for periodontal therapy, aiding strategies to improve oral health. Copyright © 2017 Elsevier Ltd. All rights reserved.

Funding Public Higher Education in Colorado: How Has the College Opportunity Funding Model Impacted Educational Funding and Performance?

ERIC Educational Resources Information Center

Middlemist, George Edward

2017-01-01

During the 2004 legislative session, the Colorado General Assembly enacted Senate Bill 189 (SB189), which established the first system of college vouchers in the United States. The supporters of SB189 hoped that the voucher system, called the College Opportunity Fund (COF), would: 1) stabilize the flow of state funding to higher education; 2)…

Regenerative Simulation of Response Times in Networks of Queues.

DTIC Science & Technology

1979-11-01

i jobs at center 1. Nov consider the network of queues in Figure 2.2, formulated (Lewis and Shedler ( 1971 )) as a model of system overhead in...7.2 leading to point estimates and confidence intervals for the quantity r(f) are that the pairs of random variables {( V(fHk) : kall (9.2.3) are...189 Next we show that P’=P. Since P ’m"CIP for all i, we can use the Skorohod representation theorem (see Skorohod (1956) or Billingsley ( 1971 )) to

The developmental costs of high self-esteem for antisocial children.

PubMed

Menon, Madhavi; Tobin, Desiree D; Corby, Brooke C; Menon, Meenakshi; Hodges, Ernest V E; Perry, David G

2007-01-01

Two hypotheses--high self-esteem leads children to act on antisocial cognitions (disposition-activating hypothesis) and high self-esteem leads children to rationalize antisocial conduct (disposition-rationalizing hypothesis)--were investigated in two longitudinal studies. In Study 1 (N= 189; mean age = 11.1 years), antisocial behavior was aggression; in Study 2 (N= 407; mean age = 10.8 years) it was avoidance of the mother. In both studies, there was little evidence for the disposition-activating hypothesis but considerable support for the disposition-rationalizing hypothesis. Over time, aggressive children with high self-esteem increasingly valued the rewards that aggression offers and belittled their victims, and avoidant children with high self-esteem increasingly viewed their mother as harassing and uninvolved. For antisocial children, high self-esteem carries costs.

IGF-I Polymorphism is Associated with Lean Mass, Exercise Economy and Performance Among Premenopausal Women

PubMed Central

López-Alarcón, Mardya; Hunter, Gary R.; Gower, Barba A.; Fernández, José R.

2007-01-01

Background We undertook this study to investigate the association of a genetic polymorphism of the insulin-like growth factor, IGF-I189, on body composition, exercise performance and exercise economy, after controlling for the independent effect of race as assessed by African genetic admixture (AFADM). Methods A total of 114 premenopausal sedentary women were genotyped for IGF-I189, obtaining measures of fat mass, lean body mass, VO2 during cycling and stairclimbing, time on treadmill and leg strength. A quantitative value for AFADM was derived from genotypic information of approximately 40 ancestry informative markers and used as covariate in statistical models. Results After adjusting for AFADM, IGF-I189 was negatively associated with lean body mass (p = 0.029) and lean leg mass (p = 0.050). Leg strength was not associated with the presence/absence of IGF-I189 (p = 0.380), but carriers of the allele demonstrated a longer time on the treadmill (p = 0.015) after adjusting for AFADM. There was also a negative relationship between oxygen uptake during cycling and presence of the IGF-I189 independent of AFADM (p = 0.010). Conclusion Independent of AFADM, individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance. PMID:17174724

Review of Specifications for Zinc-Rich Paints,

DTIC Science & Technology

1979-09-01

inspected in 1976, the repair inorganic zinc was in very poor condition due to extensive " chicken pox " rusting. The original red lead alkyd and basic...Nebraska H-186 New Hampshire H-188 New Jersey H-189 /y’/9 7’ 𔃼 New Mexico H(-216.0 North Carolina H-217 North Dakota l1- 246 Ohio H-247 Oklahoma H-254...8217l.% 2. Olharfing I r A1 1 1e a £I )II d To be separately packaged in multiples of 0 54 pound of pox der per M . Cnpost vehicle. One 2.70 pound

The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization.

PubMed

Goring, Mark E; Leibovitch, Matthew; Gea-Mallorqui, Ester; Karls, Shawn; Richard, Francis; Hanic-Joyce, Pamela J; Joyce, Paul B M

2013-10-01

We report that the temperature-sensitive (ts) phenotype in Saccharomyces cerevisiae associated with a variant tRNA nucleotidyltransferase containing an amino acid substitution at position 189 results from a reduced ability to incorporate AMP and CMP into tRNAs. We show that this defect can be compensated for by a second-site suppressor converting residue arginine 64 to tryptophan. The R64W substitution does not alter the structure or thermal stability of the enzyme dramatically but restores catalytic activity in vitro and suppresses the ts phenotype in vivo. R64 is found in motif A known to be involved in catalysis and nucleotide triphosphate binding while E189 lies within motif C previously thought only to connect the head and neck domains of the protein. Although mutagenesis experiments indicate that residues R64 and E189 do not interact directly, our data suggest a critical role for residue E189 in enzyme structure and function. Both R64 and E189 may contribute to the organization of the catalytic domain of the enzyme. These results, along with overexpression and deletion analyses, show that the ts phenotype of cca1-E189F does not arise from thermal instability of the variant tRNA nucleotidyltransferase but instead from the inability of a partially active enzyme to support growth only at higher temperatures. © 2013.

Effect of Pseudomonas fluorescens RB4 and Bacillus subtilis 189 on the phytoremediation potential of Catharanthus roseus (L.) in Cu and Pb-contaminated soils.

PubMed

Khan, Waheed Ullah; Ahmad, Sajid Rashid; Yasin, Nasim Ahmad; Ali, Aamir; Ahmad, Aqeel

2017-06-03

The remediation of heavy metal-contaminated soils has become a critical issue due to toxic effects of these metals on living organisms. The current research was conducted to study the effect of Pseudomonas fluorescens RB4 and Bacillus subtilis 189 on the growth and phytoremediation potential of Catharanthus roseus in Cu- and Pb-contaminated soils. The bacterial strains exhibited significantly higher level of water-extractable Pb and Cu in Pb, Cu, and Cu+Pb-contaminated. The P. fluorescens RB4 inoculated plants, produced 102%, 48%, and 45% higher fresh weight (FW) in soils contaminated with Cu, Pb, and both elements, respectively, as compared to un-inoculated control plants. Similarly, B. subtilis 189 inoculated plants produced 108%, 43%, and 114% more FW in the presence of Cu, Pb, and both elements. The plants co-cultivated with both bacteria exhibited 121%, 102%, and 177% higher FW, in Cu, Pb, and both elements contaminated soils, as compared to respective un-inoculated control. Co-cultivation of P. fluorescens RB4, B. subtilis 189, and P. fluorescens RB4 + B. subtilis 189 resulted in higher accumulation of Cu and Pb in shoots of the C. roseus grown in contaminated soils as compared to un-inoculated control. Bacterial treatments also improved the translocation and metal bioconcentration factors. The growth and phytoextraction capability of C. roseus was improved by inoculation of P. fluorescens RB4 and B. subtilis 189.

Publications - GMC 189 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 189 Publication Details Title: Apatite and zircon fission track analyses of 9 selected wells analyses of 9 selected wells in the NPRA, Alaska: Alaska Division of Geological & Geophysical Surveys

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.33-1 - When made.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CERTIFICATION Sanitary Inspections § 189.33-1 When made. (a) An inspection of quarters, toilet and washing spaces, serving pantries, galleys, etc., shall be made at least once in every month. If the route of the...

46 CFR 189.35-90 - Weight handling gear manufactured prior to March 1, 1968.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Weight Handling Gear § 189.35-90 Weight handling..., will be accepted on the basis of appropriate tests and examinations should plans or other technical...

Corporations now included under Section 189

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arlinghaus, B.P.; Anderson, D.T.

1983-12-01

This article examines some of the issues, including the ''real property'' question, that corporations may encounter in implementing the provisions of Code Section 189 and its regulations. The extension of 189 to regular corporations represents a significant change in congressional intent, since it was originally enacted as a reform measure and is now primarily a provision to raise revenue at a time when Congress is facing a large dificit. Code Section 189 was conceived and enacted in haste, however, and this expansion will undoubtedly have an adverse impact on capital investment at a time when stimulation is needed for themore » economy as a whole. The workload of the courts and the Internal Revenue Service will certainly increase. Careful drafting of the regulations could anticipate potential issues and clarify them in the drafting stage. The meaning of real property, capitalization rate, capitalization period, and self-constructed assets all need to be carefully addressed. 18 references.« less

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.

PubMed

Moosajee, Mariya; Gregory-Evans, Kevin; Ellis, Charles D; Seabra, Miguel C; Gregory-Evans, Cheryl Y

2008-12-15

The extensive molecular genetic heterogeneity seen with inherited eye disease is a major barrier to the development of gene-based therapeutics. The underlying molecular pathology in a considerable proportion of these diseases however are nonsense mutations leading to premature termination codons. A therapeutic intervention targeted at this abnormality would therefore potentially be relevant to a wide range of inherited eye diseases. We have taken advantage of the ability of aminoglycoside drugs to suppress such nonsense mutations and partially restore full-length, functional protein in a zebrafish model of choroideraemia (chm(ru848); juvenile chorio-retinal degeneration) and in two models of ocular coloboma (noi(tu29a) and gup(m189); congenital optic fissure closure defects). In vitro cell-based assays showed significant readthrough with two drugs, gentamicin and paromomycin, which was confirmed by western blot and in vitro prenylation assays. The presence of either aminoglycoside during zebrafish development in vivo showed remarkable prevention of mutant ocular phenotypes in each model and a reduction in multisystemic defects leading to a 1.5-1.7-fold increase in survival. We also identified a significant reduction in abnormal cell death shown by TUNEL assay. To test the hypothesis that optic fissure closure was apoptosis-dependent, the anti-apoptotic agents, curcumin and zVAD-fmk, were tested in gup(m189) embryos. Both drugs were found to reduce the size of the coloboma, providing molecular evidence that cell death is required for optic fissure remodelling. These findings draw attention to the value of zebrafish models of eye disease as useful preclinical drug screening tools in studies to identify molecular mechanisms amenable to therapeutic intervention.

12. General Arrangement Plan, Building 189D, U.S. Atomic Energy Commission, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. General Arrangement Plan, Building 189-D, U.S. Atomic Energy Commission, General Electric Company, Dwg. No. H-1-11068, 1958. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-Based Nanovaccine

PubMed Central

Agallou, Maria; Margaroni, Maritsa; Athanasiou, Evita; Toubanaki, Dimitra K.; Kontonikola, Katerina; Karidi, Konstantina; Kammona, Olga; Kiparissides, Costas

2017-01-01

Background Through their increased potential to be engaged and processed by dendritic cells (DCs), nanovaccines consisting of Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with both antigenic moieties and adjuvants are attractive candidates for triggering specific defense mechanisms against intracellular pathogens. The aim of the present study was to evaluate the immunogenicity and prophylactic potential of a rationally designed multi-epitope peptide of Leishmania Cysteine Protease A (CPA160-189) co-encapsulated with Monophosphoryl lipid A (MPLA) in PLGA NPs against L. infantum in BALB/c mice and identify immune markers correlated with protective responses. Methodology/Principal Findings The DCs phenotypic and functional features exposed to soluble (CPA160-189, CPA160-189+MPLA) or encapsulated in PLGA NPs forms of peptide and adjuvant (PLGA-MPLA, PLGA-CPA160-189, PLGA-CPA160-189+MPLA) was firstly determined using BALB/c bone marrow-derived DCs. The most potent signatures of DCs maturation were obtained with the PLGA-CPA160-189+MPLA NPs. Subcutaneous administration of PLGA-CPA160-189+MPLA NPs in BALB/c mice induced specific anti-CPA160-189 cellular and humoral immune responses characterized by T cells producing high amounts of IL-2, IFN-γ and TNFα and IgG1/IgG2a antibodies. When these mice were challenged with 2x107 stationary phase L. infantum promastigotes, they displayed significant reduced hepatic (48%) and splenic (90%) parasite load at 1 month post-challenge. This protective phenotype was accompanied by a strong spleen lymphoproliferative response and high levels of IL-2, IFN-γ and TNFα versus low IL-4 and IL-10 secretion. Although, at 4 months post-challenge, the reduced parasite load was preserved in the liver (61%), an increase was detected in the spleen (30%), indicating a partial vaccine-induced protection. Conclusions/Significance This study provide a basis for the development of peptide-based nanovaccines against leishmaniasis, since it reveals that vaccination with well-defined Leishmania MHC-restricted epitopes extracted from various immunogenic proteins co-encapsulated with the proper adjuvant or/and phlebotomine fly saliva multi-epitope peptides into clinically compatible PLGA NPs could be a promising approach for the induction of a strong and sustainable protective immunity. PMID:28114333

1. 185/189D in center, north end west facades (190D front ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. 185/189-D in center, north end west facades (190-D front left and west facade; 195-D rear right). Looking south. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction.

PubMed

Nawroth, Frank; Tandler-Schneider, Andreas; Bilger, Wilma

2015-01-01

This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI) alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles ≥15 mm). Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population). The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%), 50.0 IU (n=1,056 from N=3,189; 33.1%), and 75.0 IU (n=738 from N=3,189; 23.1%) on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%), 50.0 IU (n=922 from N=3,189; 28.9%), and 75.0 IU (n=895 from N=3,189; 28.1%) on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU) of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI.

Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction

PubMed Central

Nawroth, Frank; Tandler-Schneider, Andreas; Bilger, Wilma

2015-01-01

This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic and undergoing ovulation induction (OI) alone or OI with intrauterine insemination. The primary endpoint was the proportion of patients who achieved monofollicular or bifollicular development (defined as one or two follicles ≥15 mm). Secondary endpoints included characteristics of ovulation stimulation treatment, such as mean total and mean daily r-hFSH doses. Data were analyzed for 3,193 patients from 30 German fertility centers. The proportion of patients with monofollicular or bifollicular development was 71.1% (n=2,270 of a total of 3,193 patients; intent-to-treat population). The mean±standard deviation total and daily doses of r-hFSH were 696.9±542.5 IU and 61.7±29.4 IU, respectively. The three doses prescribed most frequently were: 37.5 IU (n=703 from N=3,189; 22.0%), 50.0 IU (n=1,056 from N=3,189; 33.1%), and 75.0 IU (n=738 from N=3,189; 23.1%) on the first day of stimulation; and 37.5 IU (n=465 from N=3,189; 14.6%), 50.0 IU (n=922 from N=3,189; 28.9%), and 75.0 IU (n=895 from N=3,189; 28.1%) on the last day of stimulation. This noninterventional, post-marketing surveillance study found that monofollicular or bifollicular development was achieved in 71% of patients studied and the small dose increment (12.5 IU) of the redesigned follitropin alfa pen allowed individualized treatment of women undergoing OI. PMID:25926755

Increased expression of VEGF121/VEGF165-189 ratio results in a significant enhancement of human prostate tumor angiogenesis.

PubMed

Catena, Raul; Muniz-Medina, Vanessa; Moralejo, Beatriz; Javierre, Biola; Best, Carolyn J M; Emmert-Buck, Michael R; Green, Jeffrey E; Baker, Carl C; Calvo, Alfonso

2007-05-15

Vascular endothelial growth factor (VEGF) is a proangiogenic factor upregulated in many tumors. The alternative splicing of VEGF mRNA renders 3 major isoforms of 121, 165 and 189 amino-acids in humans (1 less amino-acid for each mouse VEGF isoform). We have designed isoform specific real time QRT-PCR assays to quantitate VEGF transcripts in mouse and human normal and malignant prostates. In the human normal prostate, VEGF(165) was the predominant isoform (62.8% +/- 5.2%), followed by VEGF(121) (22.5% +/- 6.3%) and VEGF(189) (p < 0.001) (14.6% +/- 2.1%). Prostate tumors showed a significant increase in the percentage of VEGF(121) and decreases in VEGF(165) (p < 0.01) and VEGF(189) (p < 0.05). However, the amount of total VEGF mRNA was similar between normal and malignant prostates. VEGF(164) was the transcript with the highest expression in the mouse normal prostate. Unlike human prostate cancer, tumors from TRAMP mice demonstrated a significant increase in total VEGF mRNA levels and in each of the VEGF isoforms, without changes in the relative isoform ratios. Morpholino phosphorodiamide antisense oligonucleotide technology was used to increase the relative amount of VEGF(121) while proportionally decreasing VEGF(165) and VEGF(189) levels in human prostate cell lines, through the modification of alternative splicing, without changing transcription levels and total amount of VEGF. The increase in the VEGF(121)/VEGF(165-189) ratio in PC3 cells resulted in a dramatic increase in prostate tumor angiogenesis in vivo. Our results underscore the importance of VEGF(121) in human prostate carcinoma and demonstrate that the relative expression of the different VEGF isoforms has an impact on prostate carcinogenesis. (c) 2007 Wiley-Liss, Inc.

Ecology of Harmful Algae

NASA Astrophysics Data System (ADS)

Roelke, Daniel L.

2007-07-01

Edna Graneli and Jefferson T. Turner, Editors;Ecological Studies Series, Vol. 189; Springer; ISBN 3540322094; 413 pp.; 2006; $195 Harmful algal blooms (HABs) affect commercially and recreationally important species, human health, and ecosystem functioning. Hallmark events are the visually stunning blooms where waters are discolored and filled with ichthyotoxin-producing algae that lead to large fish kills. Of most concern, however, are HABs that pose a threat to human health. For example, some phycotoxins bioaccumulate in the guts and tissues of commercially and recreationally important species that when consumed by humans, may result in nausea, paralysis, memory loss, and even death. In addition to the deleterious impacts of phycotoxins, HABs can be problematic in other ways. For example, the decay of blooms often leads to low dissolved oxygen in subsurface waters. Blooms also reduce light penetration into the water column. Both processes disrupt ecosystems and in some cases have completely destroyed benthic communities.

DISSPLA plotting routines for the G-189A EC/LS computer program

NASA Technical Reports Server (NTRS)

Simpson, C. D.

1982-01-01

Data from a G-189A execution is formatted and plotted. The plotting may be done at the time of execution of the program. DISSPLA plot packages are used. The user has the choice of FR80 or TEKTRONIX output.

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2011 CFR

2011-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189.180 Safrole. (a) Safrole is the chemical 4-allyl-1,2...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airplanes: Turbine engine powered: Takeoff... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a...

Y-STR INRA189 polymorphisms in Chinese yak breeds.

PubMed

Ma, Z J; Chen, S M; Sun, Y G; Xi, Y L; Li, R Z; Xu, J T; Lei, C Z

2015-12-29

To further explore Y-STR INRA189 polymorphisms in the yak, and to determine the genetic differences among yak breeds, genotyping analysis of INRA189 in 102 male yak individuals from three yak breeds in Qinghai Province of China was performed. Genotyping revealed the presence of four alleles, with sizes of 149, 155, 157, and 159 bp, respectively. Of these, the 157-bp allele, which was found with the highest frequency in the three yak breeds, was the dominant allele. Interestingly, the 149-bp allele was only detected in the Gaoyuan breed, and the 159-bp allele was only found in the Huanhu and Datong breeds. Only the 157- and 155-bp alleles were found in all three yak breeds. Taking the three yak breeds as a single population, the frequency of these four alleles was 0.0294, 0.0686, 0.8628, and 0.0392, respectively. The average polymorphism information content in the three yak breeds was 0.2379, indicating that the INRA189 was a low polymorphic Y-STR marker in yak.

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire extinguishing equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire-extinguishing equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

46 CFR 189.25-20 - Fire-extinguishing equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... each inspection for certification, periodic inspection, and at such other times as considered necessary... conducted. At each inspection for certification and periodic inspection the inspector shall conduct the... and semiportable fire-extinguishing systems shall be checked as noted in Table 189.25-20(a)(1). In...

189. Photographic copy of original construction drawing dated December 10, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

189. Photographic copy of original construction drawing dated December 10, 1932 (from Record Group 115, Denver Branch of the National Archives, Denver). TUNNEL NO.1 CONTROLLING WORKS; WATER TIGHT DOOR; CHANNEL VENT INLETS-PIER NOSE ANGLES. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

46 CFR 189.55-5 - Plans and specifications required for new construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Plan Approval § 189.55-5 Plans and specifications..., carbon dioxide, foam and sprinkling systems. (e) Marine engineering. For plans required for marine engineering equipment and systems. See Subchapter F (Marine Engineering) of this chapter. (f) Electrical...

46 CFR 189.55-5 - Plans and specifications required for new construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) OCEANOGRAPHIC RESEARCH VESSELS INSPECTION AND CERTIFICATION Plan Approval § 189.55-5 Plans and specifications..., carbon dioxide, foam and sprinkling systems. (e) Marine engineering. For plans required for marine engineering equipment and systems. See Subchapter F (Marine Engineering) of this chapter. (f) Electrical...

Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.

PubMed

Seidman, M M; Bredberg, A; Seetharam, S; Kraemer, K H

1987-07-01

Mutagenesis was studied at the DNA-sequence level in human fibroblast and lymphoid cells by use of a shuttle vector plasmid, pZ189, containing a suppressor tRNA marker gene. In a series of experiments, 62 plasmids were recovered that had two to six base substitutions in the 160-base-pair marker gene. Approximately 20-30% of the mutant plasmids that were recovered after passing ultraviolet-treated pZ189 through a repair-proficient human fibroblast line contained these multiple mutations. In contrast, passage of ultraviolet-treated pZ189 through an excision-repair-deficient (xeroderma pigmentosum) line yielded only 2% multiple base substitution mutants. Introducing a single-strand nick in otherwise unmodified pZ189 adjacent to the marker, followed by passage through the xeroderma pigmentosum cells, resulted in about 66% multiple base substitution mutants. The multiple mutations were found in a 160-base-pair region containing the marker gene but were rarely found in an adjacent 170-base-pair region. Passing ultraviolet-treated or nicked pZ189 through a repair-proficient human B-cell line also yielded multiple base substitution mutations in 20-33% of the mutant plasmids. An explanation for these multiple mutations is that they were generated by an error-prone polymerase while filling gaps. These mutations share many of the properties displayed by mutations in the immunoglobulin hypervariable regions.

Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

PubMed Central

Reiner, Anton; Heldt, Scott A.; Presley, Chaela S.; Guley, Natalie H.; Elberger, Andrea J.; Deng, Yunping; D’Surney, Lauren; Rogers, Joshua T.; Ferrell, Jessica; Bu, Wei; Del Mar, Nobel; Honig, Marcia G.; Gurley, Steven N.; Moore, Bob M.

2014-01-01

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50–60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (CB2), we evaluated the effectiveness of the novel CB2 receptor inverse agonist SMM-189 in altering microglial activation and mitigating deficits after mild TBI. In vitro analysis indicated that SMM-189 converted human microglia from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype. Studies in mice showed that daily administration of SMM-189 for two weeks beginning shortly after blast greatly reduced the motor, visual, and emotional deficits otherwise evident after 50–60 psi blasts, and prevented brain injury that may contribute to these deficits. Our results suggest that treatment with the CB2 inverse agonist SMM-189 after a mild TBI event can reduce its adverse consequences by beneficially modulating microglial activation. These findings recommend further evaluation of CB2 inverse agonists as a novel therapeutic approach for treating mild TBI. PMID:25561230

Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

PubMed

Reiner, Anton; Heldt, Scott A; Presley, Chaela S; Guley, Natalie H; Elberger, Andrea J; Deng, Yunping; D'Surney, Lauren; Rogers, Joshua T; Ferrell, Jessica; Bu, Wei; Del Mar, Nobel; Honig, Marcia G; Gurley, Steven N; Moore, Bob M

2014-12-31

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50-60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (CB2), we evaluated the effectiveness of the novel CB2 receptor inverse agonist SMM-189 in altering microglial activation and mitigating deficits after mild TBI. In vitro analysis indicated that SMM-189 converted human microglia from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype. Studies in mice showed that daily administration of SMM-189 for two weeks beginning shortly after blast greatly reduced the motor, visual, and emotional deficits otherwise evident after 50-60 psi blasts, and prevented brain injury that may contribute to these deficits. Our results suggest that treatment with the CB2 inverse agonist SMM-189 after a mild TBI event can reduce its adverse consequences by beneficially modulating microglial activation. These findings recommend further evaluation of CB2 inverse agonists as a novel therapeutic approach for treating mild TBI.

50 CFR 216.189 - Renewal of Letters of Authorization.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.189 Renewal of Letters of... each SURTASS LFA sonar operation; (3) Timely receipt of the monitoring reports required under § 216.185... comment on the proposed modification. Amending the areas for upcoming SURTASS LFA sonar operations is not...

50 CFR 216.189 - Renewal of Letters of Authorization.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Array Sensor System Low Frequency Active (SURTASS LFA sonar) Sonar § 216.189 Renewal of Letters of... each SURTASS LFA sonar operation; (3) Timely receipt of the monitoring reports required under § 216.185... comment on the proposed modification. Amending the areas for upcoming SURTASS LFA sonar operations is not...

78 FR 38922 - Foreign-Trade Zone 189-Kent/Ottawa/Muskegon Counties, Michigan; Authorization of Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-19-2013] Foreign-Trade Zone 189--Kent/Ottawa/Muskegon Counties, Michigan; Authorization of Production Activity; Southern Lithoplate, Inc. (Aluminum Printing Plates); Grand Rapids, Michigan On February 22, 2013, Southern Lithoplate, Inc. submitted a...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

14 CFR 91.189 - Category II and III operations: General operating rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... pilot who is controlling the aircraft has appropriate instrumentation for the type of flight control... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Flight Rules Instrument Flight Rules § 91.189 Category II and III operations: General operating rules. (a) No...

189. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

189. Photocopy of drawing, Twin Falls Canal Company, date unknown. ROCK CREEK CROSSING, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; BLUEPRINT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

28 CFR 115.189 - Data storage, publication, and destruction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Data storage, publication, and... ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Data Collection and Review § 115.189 Data storage, publication, and destruction. (a) The agency shall ensure that data collected pursuant to § 115.187 are...

PHOTOGRAPH NUMBERS 40, 39, 38 FORM A 189 DEGREE PANORAMA ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PHOTOGRAPH NUMBERS 40, 39, 38 FORM A 189 DEGREE PANORAMA FROM LEFT TO RIGHT. PHOTOGRAPH NUMBER 38 LOOKING NORTHEAST TO SKYLINE FROM ROOF OF POLSON BUILDING; PHOTOGRAPH NUMBER 39 VIEW NORTH; PHOTOGRAPH NUMBER 40 VIEW NORTHWEST. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

Blood lead is a predictor of homocysteine levels in a population-based study of older adults.

PubMed

Schafer, Jyme H; Glass, Thomas A; Bressler, Joseph; Todd, Andrew C; Schwartz, Brian S

2005-01-01

Lead and homocysteine are both associated with cardiovascular disease and cognitive dysfunction. We evaluated the relations among blood lead, tibia lead, and homocysteine levels by cross-sectional analysis of data among subjects in the Baltimore Memory Study, a longitudinal study of 1,140 randomly selected residents in Baltimore, Maryland, who were 50-70 years of age. Tibia lead was measured by (superscript)109(/superscript)Cd K-shell X-ray fluorescence. The subject population had a mean +/- SD age of 59.3 +/- 5.9 years and was 66.0% female, 53.9% white, and 41.4% black or African American. Mean +/- SD blood lead, tibia lead, and homocysteine levels were 3.5 +/- 2.4 microg/dL, 18.9 +/- 12.5 microg/g, and 10.0 +/- 4.1 micromol/L, respectively. In unadjusted analysis, blood lead and homocysteine were moderately correlated (Pearson's r = 0.27, p < 0.01). After adjustment for age, sex, race/ethnicity, educational level, tobacco and alcohol consumption, and body mass index using multiple linear regression, results revealed that homocysteine levels increased 0.35 micromol/L per 1.0 microg/dL increase in blood lead (p < 0.01). The relations of blood lead with homocysteine levels did not differ in subgroups distinguished by age, sex, or race/ethnicity. Tibia lead was modestly correlated with blood lead (Pearson's r = 0.12, p < 0.01) but was not associated with homocysteine levels. To our knowledge, these are the first data to reveal an association between blood lead and homocysteine. These results suggest that homocysteine could be a mechanism that underlies the effects of lead on the cardiovascular and central nervous systems, possibly offering new targets for intervention to prevent the long-term consequences of lead exposure.

Dietary and inhalation intake of lead and estimation of blood lead levels in adults and children in Kanpur, India.

PubMed

Sharma, Mukesh; Maheshwari, Mayank; Morisawa, S

2005-12-01

This research was initiated to study lead levels in various food items in the city of Kanpur, India, to assess the dietary intake of lead and to estimate blood lead (PbB) levels, a biomarker of lead toxicity. For this purpose, sampling of food products, laboratory analysis, and computational exercises were undertaken. Specifically, six food groups (leafy vegetables, nonleafy vegetables, fruits, pulses, cereals, and milk), drinking water, and lead air concentration were considered for estimating lead intake. Results indicated highest lead content in leafy vegetables followed by pulses. Fruits showed low lead content and drinking water lead levels were always within tolerable limits. It was estimated that average daily lead intake through diet was about 114 microg/day for adults and 50 microg/day in children; tolerable limit is 250 microg/day for adults and 90 microg/day for children. The estimated lead intakes were translated into the resultant PbB concentrations for children and adults using a physiologically-based pharmacokinetic (PBPK) model. Monte Carlo simulation of PbB level variations for adults showed that probability of exceeding the tolerable limit of PbB (i.e.,10 microg/dL) was 0.062 for the pre-unleaded and 0.000328 for the post-unleaded gasoline period. The probability of exceeding tolerable limits in PbB level was reduced by a factor of 189 in the post-unleaded scenario. The study also suggested that in spite of the introduction of unleaded gasoline, children continue to be at a high risk (probability of exceeding 10 microg/dL = 0.39) because of a high intake of lead per unit body weight.

First detection of lead in black paper from intraoral film: an environmental concern.

PubMed

Guedes, Débora F C; Silva, Reginaldo S; da Veiga, Márcia A M S; Pecora, Jesus D

2009-10-30

Lead (Pb) contamination in the black paper that recovers intraoral films (BKP) has been investigated. BKP samples were collected from the Radiology Clinics of the Dental School of Ribeirão Preto, University of São Paulo, Brazil. For sake of comparison, four different methods were used. The results revealed the presence of high lead levels, well above the maximum limit allowed by the legislation. Pb contamination levels achieved after the following treatments: paper digestion in nitric acid, microwave treatment, DIN38414-54 method and TCLP method were 997 microg g(-1), 189 microg g(-1), 20.8 microg g(-1), and 54.0 microg g(-1), respectively. Flame atomic absorption spectrometry (FAAS) and inductively coupled plasma mass spectrometry (ICP-MS) were employed for lead determination according to the protocols of the applied methods. Lead contamination in used BKP was confirmed by scanning electron microscopy coupled with energy dispersive X-ray microanalysis (SEM-EDS). All the SEM imaging was carried out in the secondary electron mode (SE) and backscattered-electron mode (QBSD) following punctual X-ray fluorescence spectra. Soil contamination derived from this product revealed the urgent need of addressing this problem. These elevated Pb levels, show that a preliminary treatment of BKP is mandatory before it is disposed into the common trash. The high lead content of this material makes its direct dumping into the environment unwise.

49 CFR 192.189 - Vaults: Drainage and waterproofing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Design of Pipeline Components § 192.189 Vaults: Drainage and waterproofing. (a) Each vault must be designed so as to minimize... applicable requirements of Class 1, Group D, of the National Electrical Code, ANSI/NFPA 70. [35 FR 13257, Aug...

Department of Agriculture Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... Import Restrictions on Certain 0579-AC74 Live Fish 189 Scrapie in Sheep and Goats 0579-AC92 190 Plant..., Farming Experience as an Eligibility Requirement; 5201, Eligibility of Equine Farmers and Ranchers for... Phone: 301 734-8695 RIN: 0579-AC74 189. SCRAPIE IN SHEEP AND GOATS Legal Authority: 7 USC 8301 to 8317...

Simultaneous LOFAR and AMI-LA observations of MAXI J1820+070

NASA Astrophysics Data System (ADS)

Broderick, Jess; Bright, Joe; Russell, Thomas; Rowlinson, Antonia; Fender, Rob; Done, Chris

2018-05-01

We report on the detection of MAXI J1820+070 (e.g. ATel #11399, #11418, #11420) with the Low-Frequency Array (LOFAR). Observations in the high band (115-189 MHz) were carried out from 2018 April 27 02:32:33.0-04:32:33.0 UTC (MJD 58235.106-58235.189).

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

47 CFR 73.189 - Minimum antenna heights or field strength requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Minimum antenna heights or field strength... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.189 Minimum antenna heights or field..., frequency, or transmitter location must also request authority to install a new antenna system or to make...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airplanes: Turbine engine powered: Takeoff... Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a turbine engine powered airplane may take off that airplane at a weight greater than that listed in the...

14 CFR 121.189 - Airplanes: Turbine engine powered: Takeoff limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplanes: Turbine engine powered: Takeoff... Limitations § 121.189 Airplanes: Turbine engine powered: Takeoff limitations. (a) No person operating a turbine engine powered airplane may take off that airplane at a weight greater than that listed in the...

47 CFR 87.189 - Requirements for public correspondence equipment and operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AVIATION SERVICES Aircraft Stations § 87.189 Requirements for... continuous watch must be maintained on the frequencies used for safety and regularity of flight while public... interfere with message pertaining to safety of life and property or regularity of flight, or when ordered by...

Kinase activity of OsBRI1 is essential for brassinosteroids to regulate rice growth and development.

PubMed

Zhao, Jinfeng; Wu, Chenxi; Yuan, Shoujiang; Yin, Liang; Sun, Wei; Zhao, Qinglei; Zhao, Baohua; Li, Xueyong

2013-02-01

Brassinosteroids (BRs) are steroid hormones that participate in multiple biological processes. In this paper, we characterized a classic rice mutant Fn189 (dwarf54, d54) showing semi-dwarf stature and erect leaves. The coleoptile elongation and root growth was less affected in Fn189 than wild-type plant by the exogenous application of eBL, the most active form of BRs. Lamina joint inclination assay and morphological analysis in darkness further showed that Fn189 mutant plant was insensitive to exogenous eBL. Through map-based cloning, Fn189 was found to be a novel allelic mutant of the DWARF 61 (D61) gene, which encodes the putative BRs receptor OsBRI1. A single base mutation caused the I834F substitution in the OsBRI1 kinase domain. Consequently, kinase activity of OsBRI1 was found to decrease dramatically. Taken together, the kinase activity of OsBRI1 is essential for brassinosteroids to regulate normal plant growth and development in rice. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Shape-Coexistence in ^191Tl and ^189Tl.

NASA Astrophysics Data System (ADS)

Reviol, W.; Riedinger, L. L.; Carpenter, M. P.; Fischer, S. M.; Janssens, R. V. F.; Nisius, D.; Moore, E. F.

1997-10-01

The Tl isotopes at A ~ 190 are, like the neighboring Hg and Pb nuclei, recognized for a multiplicity of shapes. These shapes reach from spherical or weakly deformed oblate to well-deformed and superdeformed prolate, as mainly inferred from γ -ray spectroscopic studies. We have previously reported on shape-coexistence phenomena in ^191Tl and ^189Tl(W. Reviol et al., Phys. Scr. T56, 167 (1995), and references therein.). Here, we will focus on new results on the ``normally" deformed states in both nuclei obtained from a recent and an upcoming experiment at GAMMASPHERE. The states in ^191Tl and ^189Tl are populated by the reactions ^159Tb(^36S,4n)^191Tl at E_lab = 165 MeV and ^156Gd(^37Cl,4n)^189Tl at E_lab = 171 MeV, respectively. One of the questions to be addressed is about the main level structure in the positive-parity branch of ^191Tl^2. Whether this structure is oblate-collective in nature, like the [505]9/2^- yrast band, we will try to answer on the basis of the available lifetime data.

Improved Power Conversion Efficiency of Inverted Organic Solar Cells by Incorporating Au Nanorods into Active Layer.

PubMed

He, Yeyuan; Liu, Chunyu; Li, Jinfeng; Zhang, Xinyuan; Li, Zhiqi; Shen, Liang; Guo, Wenbin; Ruan, Shengping

2015-07-29

This Research Article describes a cooperative plasmonic effect on improving the performance of organic solar cells. When Au nanorods(NRs) are incorporated into the active layers, the designed project shows superior enhanced light absorption behavior comparing with control devices, which leads to the realization of organic solar cell with power conversion efficiency of 6.83%, accounting for 18.9% improvement. Further investigations unravel the influence of plasmonic nanostructures on light trapping, exciton generation, dissociation, and charge recombination and transport inside the thin films devices. Moreover, the introduction of high-conductivity Au NRs improves electrical conductivity of the whole device, which contributes to the enhanced fill factor.

Overview: Homogeneous nucleation from the vapor phase-The experimental science.

PubMed

Wyslouzil, Barbara E; Wölk, Judith

2016-12-07

Homogeneous nucleation from the vapor phase has been a well-defined area of research for ∼120 yr. In this paper, we present an overview of the key experimental and theoretical developments that have made it possible to address some of the fundamental questions first delineated and investigated in C. T. R. Wilson's pioneering paper of 1897 [C. T. R. Wilson, Philos. Trans. R. Soc., A 189, 265-307 (1897)]. We review the principles behind the standard experimental techniques currently used to measure isothermal nucleation rates, and discuss the molecular level information that can be extracted from these measurements. We then highlight recent approaches that interrogate the vapor and intermediate clusters leading to particle formation, more directly.

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

33 CFR 110.189a - Key West Harbor, Key West, Fla., naval explosives anchorage area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Key West Harbor, Key West, Fla..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.189a Key West Harbor, Key West, Fla., naval explosives anchorage area. (a) The anchorage ground. A circular area with its...

49 CFR 572.186 - Abdomen assembly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... part of the dummy assembly shown in drawing 175-0000 including load sensors specified in § 572.189(e... measuring sensor in the abdomen as shown in Figure U5; (5) The impactor impacts the dummy's abdomen at 4.0 m... of the forces of the three abdominal load sensors, specified in 572.189(e), shall be not less than...

R-189 (C-620) air compressor control logic software documentation. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, K.E.

1995-06-08

This relates to FFTF plant air compressors. Purpose of this document is to provide an updated Computer Software Description for the software to be used on R-189 (C-620-C) air compressor programmable controllers. Logic software design changes were required to allow automatic starting of a compressor that had not been previously started.

21 CFR 1303.22 - Procedure for applying for individual manufacturing quotas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... manufacturing quotas. Any person who is registered to manufacture any basic class of controlled substance listed in Schedule I or II and who desires to manufacture a quantity of such class shall apply on DEA Form 189 for a manufacturing quota for such quantity of such class. Copies of DEA Form 189 may be obtained...

Estimation of Δ R/ R values by benchmark study of the Mössbauer Isomer shifts for Ru, Os complexes using relativistic DFT calculations

NASA Astrophysics Data System (ADS)

Kaneko, Masashi; Yasuhara, Hiroki; Miyashita, Sunao; Nakashima, Satoru

2017-11-01

The present study applies all-electron relativistic DFT calculation with Douglas-Kroll-Hess (DKH) Hamiltonian to each ten sets of Ru and Os compounds. We perform the benchmark investigation of three density functionals (BP86, B3LYP and B2PLYP) using segmented all-electron relativistically contracted (SARC) basis set with the experimental Mössbauer isomer shifts for 99Ru and 189Os nuclides. Geometry optimizations at BP86 theory of level locate the structure in a local minimum. We calculate the contact density to the wavefunction obtained by a single point calculation. All functionals show the good linear correlation with experimental isomer shifts for both 99Ru and 189Os. Especially, B3LYP functional gives a stronger correlation compared to BP86 and B2PLYP functionals. The comparison of contact density between SARC and well-tempered basis set (WTBS) indicated that the numerical convergence of contact density cannot be obtained, but the reproducibility is less sensitive to the choice of basis set. We also estimate the values of Δ R/ R, which is an important nuclear constant, for 99Ru and 189Os nuclides by using the benchmark results. The sign of the calculated Δ R/ R values is consistent with the predicted data for 99Ru and 189Os. We obtain computationally the Δ R/ R values of 99Ru and 189Os (36.2 keV) as 2.35×10-4 and -0.20×10-4, respectively, at B3LYP level for SARC basis set.

Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics.

PubMed

Zhou, Mingliang; Xie, Longxiang; Yang, Zhaozhen; Zhou, Jiahai; Xie, Jianping

2017-04-01

Lysine succinylation (Ksucc) is a newly identified protein posttranslational modification (PTM), which may play an important role in cellular physiology. However, the role of lysine succinylation in antibiotic resistance remains elusive. Isocitrate lyase (ICL) is crucial for broad-spectrum antibiotics tolerance in Mycobacterium tuberculosis (Mtb). We previously found that MtbICL (Rv0467) has at least three succinylated lysine residues, namely K189, K322, and K334.To explore the effect of succinylation on the activity of MtbICL, mutants' mimicry of the lysine succinylation were generated by site-directed mutagenesis. ICL-K189E mutant strain is more sensitive than the wild-type to rifampicin and streptomycin, but not isoniazid. For the in vitro activity of the purified isocitrate lyase, only K189E mutant showed significantly decreased activity. Crystal structure analysis showed that Lys189 Glu dramatically increased the pKa of Glu188 and decreased the pKa of Lys190, whereas had negligible effect on other residues within 5 Å as well as disruption of the electrostatic interaction between Lys189 and Glu182, which might prevent the closure of the active site loop and cause severe reduction of the enzyme activity. Considering the genetic, biochemical, and crystallographical evidences together, the succinylation of specific ICL residue can fine-tune the bacterial resistance to selected antibiotics. The decreased enzymatic activity resulting from the succinylation-changed electrostatic interaction might underlie this phenotype. This study provided the first insight into the link between lysine succinylation and antibiotic resistance.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batcheller, Thomas Aquinas; Taylor, Dean Dalton

Idaho Nuclear Technology and Engineering Center 300,000-gallon vessel WM-189 was filled in late 2001 with concentrated sodium bearing waste (SBW). Three airlifted liquid samples and a steam jetted slurry sample were obtained for quantitative analysis and characterization of WM-189 liquid phase SBW and tank heel sludge. Estimates were provided for most of the reported data values, based on the greater of (a) analytical uncertainty, and (b) variation of analytical results between nominally similar samples. A consistency check on the data was performed by comparing the total mass of dissolved solids in the liquid, as measured gravimetrically from a dried sample,more » with the corresponding value obtained by summing the masses of cations and anions in the liquid, based on the reported analytical data. After reasonable adjustments to the nitrate and oxygen concentrations, satisfactory consistency between the two results was obtained. A similar consistency check was performed on the reported compositional data for sludge solids from the steam jetted sample. In addition to the compositional data, various other analyses were performed: particle size distribution was measured for the sludge solids, sludge settling tests were performed, and viscosity measurements were made. WM-189 characterization results were compared with those for WM-180, and other Tank Farm Facility tank characterization data. A 2-liter batch of WM-189 simulant was prepared and a clear, stable solution was obtained, based on a general procedure for mixing SBW simulant that was develop by Dr. Jerry Christian. This WM-189 SBW simulant is considered suitable for laboratory testing for process development.« less

Baseline Serum Clinical Chemistry Values in African Green Monkeys Before and After Sulfur Mustard

DTIC Science & Technology

2007-05-01

aspartate transaminase (189 %), blood urea nitrogen (75 %), creatine kinase (721 %), and lactate dehydrogenase (114 %) one day after HD exposure...ALT, 93 %), aspartate transaminase (AST, 189 %), blood urea nitrogen (BUN, 75 %), creatine kinase (CK, 721 %), and lactate dehydrogenase (LDH, 114...alkaline phosphate (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), calcium (Ca2+), creatine kinase (CK

What Are Extraordinary Gifted Children like (Equal to or above 189 IQ)? A Study of 10 Cases

ERIC Educational Resources Information Center

Mate, Yolanda Benito

2009-01-01

After a short introduction about previous studies on extraordinarily gifted children with an IQ of over 170, this article refers to the descriptive characteristics of ten children with IQ of over 189. After this, the developmental and learning characteristics of these children are described and finally empirical research about aspects that…

Corrigendum to ;Numerical dissipation control in high order shock-capturing schemes for LES of low speed flows; [J. Comput. Phys. 307 (2016) 189-202

NASA Astrophysics Data System (ADS)

Kotov, D. V.; Yee, H. C.; Wray, A. A.; Sjögreen, Björn; Kritsuk, A. G.

2018-01-01

The authors regret for the typographic errors that were made in equation (4) and missing phrase after equation (4) in the article "Numerical dissipation control in high order shock-capturing schemes for LES of low speed flows" [J. Comput. Phys. 307 (2016) 189-202].

20 CFR 661.400 - What is the purpose of the General Statutory and Regulatory Waiver Authority provided at section...

Code of Federal Regulations, 2010 CFR

2010-04-01

... and Regulatory Waiver Authority provided at section 189(i)(4) of the Workforce Investment Act? 661.400... AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT... Authority provided at section 189(i)(4) of the Workforce Investment Act? (a) The purpose of the general...

21 CFR 1303.22 - Procedure for applying for individual manufacturing quotas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... in Schedule I or II and who desires to manufacture a quantity of such class shall apply on DEA Form 189 for a manufacturing quota for such quantity of such class. Copies of DEA Form 189 may be obtained... Administration. See the Table of DEA Mailing Addresses in § 1321.01 of this chapter for the current mailing...

Generalized EC&LSS computer program configuration control

NASA Technical Reports Server (NTRS)

Blakely, R. L.

1976-01-01

The generalized environmental control and life support system (ECLSS) computer program (G189A) simulation of the shuttle orbiter ECLSS was upgraded. The G189A component model configuration was changed to represent the current PV102 and subsequent vehicle ECLSS configurations as defined by baseline ARS and ATCS schematics. The diagrammatic output schematics of the gas, water, and freon loops were also revised to agree with the new ECLSS configuration. The accuracy of the transient analysis was enhanced by incorporating the thermal mass effects of the equipment, structure, and fluid in the ARS gas and water loops and in the ATCS freon loops. The sources of the data used to upgrade the simulation are: (1) ATCS freon loop line sizes and lengths; (2) ARS water loop line sizes and lengths; (3) ARS water loop and ATCS freon loop component and equipment weights; and (4) ARS cabin and avionics bay thermal capacitance and conductance values. A single G189A combination master program library tape was generated which contains all of the master program library versions which were previously maintained on separate tapes. A new component subroutine, PIPETL, was developed and incorporated into the G189A master program library.

Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations.

PubMed

Roxas, Mario; Jurenka, Julie

2007-03-01

The common cold is the leading cause of doctor visits in the United States and annually results in 189 million lost school days. In the course of one year the U.S. population contracts approximately 1 billion colds. Influenza infection is still a leading cause of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year in the United States. Conventional therapies for colds and flu focus primarily on temporary symptom relief and include over-the-counter antipyretics, anti-inflammatories, and decongestants. Treatment for influenza also includes prescription antiviral agents and vaccines for prevention. This article reviews the common cold and influenza viruses, presents the conventional treatment options, and highlights select botanicals (Echinacea spp., Sambucus nigra, larch arabinogalactan, Astragalus membranaceous, Baptisia tinctoria, Allium sativa, Panax quinquefolium, Eleutherococcus senticosus, Andrographis paniculata, olive leaf extract, and Isatis tinctoria) and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) that may help in the prevention and treatment of these conditions.

Using Monoclonal Antibody to Determine Lead Ions with a Localized Surface Plasmon Resonance Fiber-optic Biosensor

PubMed Central

Lin, Tsao-Jen; Chung, Mon-Fu

2008-01-01

A novel reflection-based localized surface plasmon resonance (LSPR) fiber­optic probe has been developed to determine the heavy metal lead ion concentration. Monoclonal antibody as the detecting probe containing massive amino groups to capture Pb(II)-chelate complexes was immobilized onto gold nanoparticle-modified optical fiber (NMAuOF). The optimal immobilizing conditions of monoclonal antibody on to the NMAuOF are 189 μg/mL in pH7.4 PBS for 2 h at 25°C. The absorbability of the functionalized NMAuOF sensor increases to 12.2 % upon changing the Pb(II)-EDTA level from 10 to 100 ppb with a detection limit of 0.27 ppb. The sensor retains 92.7 % of its original activity and gives reproducible results after storage in 5% D-(+)-Trehalose dehydrate solution at 4°C for 35 days. In conclusion, the monoclonal antibody-functionalized NMAuOF sensor shows a promising result for determining the concentration of Pb(II) with high sensitivity. PMID:27879723

Synergistic effect of chelators and Herbaspirillum sp. GW103 on lead phytoextraction and its induced oxidative stress in Zea mays.

PubMed

Govarthanan, Muthusamy; Kamala-Kannan, Seralathan; Kim, Seol Ah; Seo, Young-Seok; Park, Jung-Hee; Oh, Byung-Taek

2016-10-01

Phytoremediation is an in situ, low-cost strategy for cleanup of the sites contaminated with heavy metals. Experiments were conducted to assess the impact of synthetic chelators and plant growth-promoting rhizosphere bacteria (Herbaspirillum sp. GW103) on heavy metal lead (Pb) uptake in Z. mays cultivated in Pb-contaminated soil. The present study investigated the Pb phytoaccumulation rate and plant antioxidant enzyme activities in Z. mays exposed to 100 mg/kg of PbNO3. The combination of gluconic acid (GA) with Herbaspirillum sp. GW103 treatment showed higher Pb solubility (18.9 mg/kg) compared with other chelators. The chemical chelators showed the significant difference in phytoaccumulation as well as antioxidant enzyme activities. The antioxidant enzymes such as catalase, peroxidase and superoxide dismutase activities changed under Pb stress. The study indicated that increased activity of antioxidant enzymes may play as signal inducers to fight against Pb.

In vitro susceptibility of spiroplasmas to heavy-metal salts.

PubMed

Whitmore, S C; Rissler, J F; Davis, R E

1983-01-01

The susceptibility of six spiroplasma strains to heavy-metal salt was characterized in terms of minimal inhibitory concentrations and minimal biocidal concentrations in broth tube dilution tests. The strains were most susceptible to mercuric chloride and silver nitrate; less susceptible to copper sulfate, cobalt chloride, lead nitrate, and cadmium sulfate; and least susceptible to nickel chloride and zinc sulfate. Spiroplasma citri strains Maroc R8A2 and C189 were the most susceptible to five of eight heavy-metal salts, and honeybee spiroplasma strain AS576 and Spiroplasma floricola strain 23-6 were generally the least susceptible. The difference between the minimal biocidal concentrations and the minimal inhibitory concentrations was greater for certain heavy-metal salts than for others.

PTSD symptoms and sexual harassment: the role of attributions and perceived control.

PubMed

Larsen, Sadie E; Fitzgerald, Louise F

2011-09-01

Researchers have compiled significant evidence demonstrating that sexual harassment leads to psychological harm, including the full symptom picture of PTSD, but few have examined the psychological processes involved. Research on attributions among trauma victims would suggest that causal attributions and perceptions of control may be important predictors of outcomes. The authors discuss a study involving a path model that used data from 189 women involved in sexual harassment litigation. Results indicate that both self-blame and harasser blame were positively related to PTSD symptoms. Control over recovery and the perception that future harassment is unlikely were both related to fewer PTSD symptoms. Unexpectedly, perceived control over future harassment is related to higher levels of PTSD symptoms. Implications for research and practice are discussed.

Effect of Back Massage Intervention on Anxiety, Comfort, and Physiologic Responses in Patients with Congestive Heart Failure

PubMed Central

Chen, Wei-Ling; Liu, Gin-Jen; Chiang, Ming-Chu; Fu, Mao-Young; Hsieh, Yuan-Kai

2013-01-01

Abstract Background Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. Objectives The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were also analyzed. Design The study used a quasi-experimental design with one group pretest and posttest. Participants Sixty-four participants were recruited in southern Taiwan. Outcome measures The modified State Anxiety Inventory, the discomfort Visual Analogue Scale, electronic blood pressure (BP) gauges, stethoscopes and the pulse oximetry were used in this study. Results The participants' systolic BP (F (3, 189)=18.91, p<0.01), diastolic BP (F (3, 189)=13.40, p<0.01), heart rate (F (3, 189)=26.28, p<0.01), and respiratory rates (F (3, 189)=5.77, p<0.01) were significantly decreased after back massage. Oxygen saturation levels showed significant increases (F (3, 189)=42.82, p<0.01). Male participants revealed a more significant reduction in anxiety than the female participants (F (1, 50)=7.27, p=0.01). Those with more severe heart failure and greater levels of anxiety (F (2, 61)=4.31, p=0.02) and systolic BP (F (2, 61)=3.86, p=0.03) demonstrated significantly greater responses to back massage. Conclusions Back massage significantly reduced anxiety in the study population. Systolic BP decreased to a greater degree in the male participants, particularly in those with severe heart failure and greater levels of anxiety and higher systolic BP. This study was conducted without a control group. Randomized clinical trials are needed to validate the effectiveness of back massage on patients with CHF. PMID:23186129

Effect of back massage intervention on anxiety, comfort, and physiologic responses in patients with congestive heart failure.

PubMed

Chen, Wei-Ling; Liu, Gin-Jen; Yeh, Shu-Hui; Chiang, Ming-Chu; Fu, Mao-Young; Hsieh, Yuan-Kai

2013-05-01

Patients suffering from congestive heart failure (CHF) frequently feel physical suffering and anxiety. The researchers investigated whether back massage could reduce anxiety, discomfort, and physical suffering in patients with CHF. The effects of gender and severity-dependent response of back massage on anxiety and discomfort in patients were also analyzed. The study used a quasi-experimental design with one group pretest and posttest. Sixty-four participants were recruited in southern Taiwan. The modified State Anxiety Inventory, the discomfort Visual Analogue Scale, electronic blood pressure (BP) gauges, stethoscopes and the pulse oximetry were used in this study. The participants' systolic BP (F (3, 189)=18.91, p<0.01), diastolic BP (F (3, 189)=13.40, p<0.01), heart rate (F (3, 189)=26.28, p<0.01), and respiratory rates (F (3, 189)=5.77, p<0.01) were significantly decreased after back massage. Oxygen saturation levels showed significant increases (F (3, 189)=42.82, p<0.01). Male participants revealed a more significant reduction in anxiety than the female participants (F (1, 50)=7.27, p=0.01). Those with more severe heart failure and greater levels of anxiety (F (2, 61)=4.31, p=0.02) and systolic BP (F (2, 61)=3.86, p=0.03) demonstrated significantly greater responses to back massage. Back massage significantly reduced anxiety in the study population. Systolic BP decreased to a greater degree in the male participants, particularly in those with severe heart failure and greater levels of anxiety and higher systolic BP. This study was conducted without a control group. Randomized clinical trials are needed to validate the effectiveness of back massage on patients with CHF.

Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189

PubMed Central

McAfee, Samuel S.; Guley, Natalie M.; Del Mar, Nobel; Bu, Wei; Heldt, Scott A.; Honig, Marcia G.; Moore, Bob M.

2017-01-01

Abstract Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. We evaluated mPFC, hippocampus CA1, and primary somatosensory/visual cortical areas (S1/V1). Although mTBI did not alter the power of oscillations, it did cause increased coherence of θ (4-10 Hz) and β (10-30 Hz) oscillations within mPFC and S1/V1, reduced CA1 sharp-wave ripple (SWR)-evoked LFP activity in mPFC, downshifted SWR frequencies in CA1, and enhanced θ-γ phase-amplitude coupling (PAC) within mPFC. These abnormalities might be linked to the impaired memory, depression, and persevering fear seen after mTBI. Treatment with the cannabinoid type-2 (CB2) receptor inverse agonist SMM-189 has been shown to mitigate functional deficits and neuronal injury after mTBI in mice. We found that SMM-189 also reversed most of the observed neurophysiological abnormalities. This neurophysiological rescue is likely to stem from the previously reported reduction in neuron loss and/or the preservation of neuronal function and connectivity resulting from SMM-189 treatment, which appears to stem from the biasing of microglia from the proinflammatory M1 state to the prohealing M2 state by SMM-189. PMID:28828401

Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189.

PubMed

Liu, Yu; McAfee, Samuel S; Guley, Natalie M; Del Mar, Nobel; Bu, Wei; Heldt, Scott A; Honig, Marcia G; Moore, Bob M; Reiner, Anton; Heck, Detlef H

2017-01-01

Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. We evaluated mPFC, hippocampus CA1, and primary somatosensory/visual cortical areas (S1/V1). Although mTBI did not alter the power of oscillations, it did cause increased coherence of θ (4-10 Hz) and β (10-30 Hz) oscillations within mPFC and S1/V1, reduced CA1 sharp-wave ripple (SWR)-evoked LFP activity in mPFC, downshifted SWR frequencies in CA1, and enhanced θ-γ phase-amplitude coupling (PAC) within mPFC. These abnormalities might be linked to the impaired memory, depression, and persevering fear seen after mTBI. Treatment with the cannabinoid type-2 (CB2) receptor inverse agonist SMM-189 has been shown to mitigate functional deficits and neuronal injury after mTBI in mice. We found that SMM-189 also reversed most of the observed neurophysiological abnormalities. This neurophysiological rescue is likely to stem from the previously reported reduction in neuron loss and/or the preservation of neuronal function and connectivity resulting from SMM-189 treatment, which appears to stem from the biasing of microglia from the proinflammatory M1 state to the prohealing M2 state by SMM-189.

Chronic pain in the newborn: toward a definition.

PubMed

van Ganzewinkel, Christ-jan; Anand, Kanwaljeet J S; Kramer, Boris W; Andriessen, Peter

2014-11-01

Chronic pain is poorly addressed in neonatal pain research. We aimed at contributing to define the concept of chronic pain in the newborn. We designed a Web-based, 3-round Delphi survey. We invited an international panel of experts (health care providers and parents) in the fields of neonatology and neonatal pain to participate. In the first round, participants (n=189) answered 3 open-ended questions: (1) define chronic pain in your own words, (2) what are the possible causes, and (3) which signs and symptoms are used to diagnose chronic pain? The answers were categorized and summarized into 437 statements, which were valued by the participants (n=189) on a 5-point Likert scale. In the second round, the remaining participants (n=72) were asked to reflect on 65 selected statements with a mode or median ≥4 or mean ≥3.75. These threshold values provided the opportunity to reach consensus in the following round. In the third round, the remaining participants (n=33) were provided with the group and individual responses. This process resulted in 23 statements with mode, mean, and median of ≥4, on which the participants reached consensus. Although several etiologic factors were defined, no useful diagnostic criterion could be identified. The survey resulted in a description of chronic pain in the newborn. Identifying chronic pain is clinically relevant because it interferes with growth, prolongs hospitalization, leads to altered pain perception, and impairs cognitive and behavioral development.

CaNa2EDTA chelation attenuates cell damage in workers exposed to lead--a pilot study.

PubMed

Čabarkapa, A; Borozan, S; Živković, L; Stojanović, S; Milanović-Čabarkapa, M; Bajić, V; Spremo-Potparević, B

2015-12-05

Lead induced oxidative cellular damage and long-term persistence of associated adverse effects increases risk of late-onset diseases. CaNa2EDTA chelation is known to remove contaminating metals and to reduce free radical production. The objective was to investigate the impact of chelation therapy on modulation of lead induced cellular damage, restoration of altered enzyme activities and lipid homeostasis in peripheral blood of workers exposed to lead, by comparing the selected biomarkers obtained prior and after five-day CaNa2EDTA chelation intervention. The group of smelting factory workers diagnosed with lead intoxication and current lead exposure 5.8 ± 1.2 years were administered five-day CaNa2EDTA chelation. Elevated baseline activity of antioxidant enzymes Cu, Zn-SOD and CAT as well as depleted thiols and increased protein degradation products-carbonyl groups and nitrites, pointing to Pb induced oxidative damage, were restored toward normal values following the treatment. Lead showed inhibitor potency on both RBC AChE and BChE in exposed workers, and chelation re-established the activity of BChE, while RBC AChE remained unaffected. Also, genotoxic effect of lead detected in peripheral blood lymphocytes was significantly decreased after therapy, exhibiting 18.9% DNA damage reduction. Administration of chelation reversed the depressed activity of serum PON 1 and significantly decreased lipid peroxidation detected by the post-chelation reduction of MDA levels. Lactate dehydrogenase LDH1-5 isoenzymes levels showed evident but no significant trend of restoring toward normal control values following chelation. CaNa2EDTA chelation ameliorates the alterations linked with Pb mediated oxidative stress, indicating possible benefits in reducing health risks associated with increased oxidative damage in lead exposed populations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Behavior of Sn-0.7Cu-xZn lead free solder on physical properties and micro structure

NASA Astrophysics Data System (ADS)

Siahaan, Erwin

2017-09-01

The issues to substitute Tin-Lead Solders is concerning the health and environmental hazards that is caused by lead, and also legislative actions around the world regarding lead toxicity, which has prompted the research community to attempt to replace solder alloys for the traditional Sn-Pb alloys lead which has been used by industrial worker throughout history because it is easily extracted and refined at a relatively low energy cost and also has a range of useful properties. Traditional industry lead has been used in soldering materials for electronic applications because it has low melting point and a soft, malleable nature, when combined with tin at the eutectic composition which causes the alloy to flow easily in the liquid state and solidifies over a very small range of temperature. One of the potential candidate to replace tin-lead solder is Sn-Cu-Zn eutectic alloy as it has a lower melting temperature. Consequently, it is of interest to determine what reactions can occur in ternary systems derived from the Sn-Cu-Zn eutectic. One such system is Sn-0.7Cu-xZn. The specimen was elaborated on physical properties. The chemical content was analyzed by using Shimadzu XRD and melting point was analyzed by using Differential Scanning Calorimeter ( DSC ). The results has shown that the highest addition of Zinc content (15%Zn) will decrease the melting temperatur to 189°C compared to Sn-Pb at 183°C Increasing the amount of Zn on Sn0.7Cu-xZn alloys will decrease Cu3Sn intermetallic coumpound.

75 FR 54806 - Approval and Promulgation of Implementation Plans-Maricopa County (Phoenix) PM-10 Nonattainment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... program is codified in ARS 49-457 and Arizona Administrative Code (AsAC) R18-2-610 and R18-2-611. ARS 49... proposing to fully approve the amendment to ARS-457 which was submitted with the 189(d) plan, we do not... registered with the control officer. These measures are implemented through ARS 49-474.05. See 189(d) plan...

Women in surgery: a survey in Switzerland.

PubMed

Kaderli, Reto; Guller, Ulrich; Muff, Brigitte; Stefenelli, Ulrich; Businger, Adrian

2010-11-01

An increasing proportion of women work in medicine; however, only few choose surgical specialties. The objective of this study was to analyze the current situation of female surgeons and surgical residents in Switzerland concerning their personal and professional fulfillment. Of 318 female surgeons and surgical residents included in our study, 189 (59.4%) returned the anonymous questionnaire. Mentor-mentee relationships were mentioned by 110 (58.2%) of the 189 respondents. On the basis of a 7-point Likert scale, these women responded that they were moderately satisfied with their professional (mean score [SD], 2.7 [1.3]) and personal (mean score [SD], 3.0 [1.7]) lives. Of the 189 respondents, 113 (59.8%) mentioned that they felt underappreciated. The most important ways suggested for increasing the attractiveness of a surgical career for women were a reduction in workload (49 respondents [25.9%]), more flexible working hours (38 respondents [20.1%]), and better structured residency programs (23 respondents [12.2%]).

A Comparison of Psychotomimetic Drug Effects on Rat Brain Norepinephrine Metabolism

DTIC Science & Technology

1973-02-19

189, No. I Copyright a 1974 by The Williams & Wilkins Co. inted in U.S.A. 7:’... .. .A K. (PA COMPARISON OF PSYCHOTOMIMETIC,_RUG EFFECTS ON...GOLDSTEIN, WILLIAM BOGGAN AND DANIEL X. FREEDMAN: A comparison of psychotomimetic drug effects on rat brain norepinephrine metabolism. J. Pharmacol. Exp...Thor. 189: 42-50,1974. V The effects of LSD, psilocybin, mescaline, amphetamine and cold water swimming stress on the metabolism of ’H-norepinephrine

Measurement of WZ and ZZ production in pp collisions at [Formula: see text] in final states with b-tagged jets.

PubMed

Chatrchyan, S; Khachatryan, V; Sirunyan, A M; Tumasyan, A; Adam, W; Bergauer, T; Dragicevic, M; Erö, J; Fabjan, C; Friedl, M; Frühwirth, R; Ghete, V M; Hartl, C; Hörmann, N; Hrubec, J; Jeitler, M; Kiesenhofer, W; Knünz, V; Krammer, M; Krätschmer, I; Liko, D; Mikulec, I; Rabady, D; Rahbaran, B; Rohringer, H; Schöfbeck, R; Strauss, J; Taurok, A; Treberer-Treberspurg, W; Waltenberger, W; Wulz, C-E; Mossolov, V; Shumeiko, N; Suarez Gonzalez, J; Alderweireldt, S; Bansal, M; Bansal, S; Cornelis, T; De Wolf, E A; Janssen, X; Knutsson, A; Luyckx, S; Ochesanu, S; Roland, B; Rougny, R; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Van Spilbeeck, A; Blekman, F; Blyweert, S; D'Hondt, J; Heracleous, N; Kalogeropoulos, A; Keaveney, J; Kim, T J; Lowette, S; Maes, M; Olbrechts, A; Strom, D; Tavernier, S; Van Doninck, W; Van Mulders, P; Van Onsem, G P; Villella, I; Caillol, C; Clerbaux, B; De Lentdecker, G; Favart, L; Gay, A P R; Léonard, A; Marage, P E; Mohammadi, A; Perniè, L; Reis, T; Seva, T; Thomas, L; Vander Velde, C; Vanlaer, P; Wang, J; Adler, V; Beernaert, K; Benucci, L; Cimmino, A; Costantini, S; Crucy, S; Dildick, S; Garcia, G; Klein, B; Lellouch, J; Mccartin, J; Ocampo Rios, A A; Ryckbosch, D; Salva Diblen, S; Sigamani, M; Strobbe, N; Thyssen, F; Tytgat, M; Walsh, S; Yazgan, E; Zaganidis, N; Basegmez, S; Beluffi, C; Bruno, G; Castello, R; Caudron, A; Ceard, L; Da Silveira, G G; Delaere, C; du Pree, T; Favart, D; Forthomme, L; Giammanco, A; Hollar, J; Jez, P; Komm, M; Lemaitre, V; Liao, J; Militaru, O; Nuttens, C; Pagano, D; Pin, A; Piotrzkowski, K; Popov, A; Quertenmont, L; Selvaggi, M; Vidal Marono, M; Vizan Garcia, J M; Beliy, N; Caebergs, T; Daubie, E; Hammad, G H; Alves, G A; Correa Martins Junior, M; Martins, T; Pol, M E; Souza, M H G; Aldá Júnior, W L; Carvalho, W; Chinellato, J; Custódio, A; Da Costa, E M; De Jesus Damiao, D; De Oliveira Martins, C; Fonseca De Souza, S; Malbouisson, H; Malek, M; Matos Figueiredo, D; Mundim, L; Nogima, H; Prado Da Silva, W L; Santaolalla, J; Santoro, A; Sznajder, A; Tonelli Manganote, E J; Vilela Pereira, A; Dias, F A; Fernandez Perez Tomei, T R; Novaes, S F; Padula, Sandra S; Bernardes, C A; Gregores, E M; Mercadante, P G; Genchev, V; Iaydjiev, P; Marinov, A; Piperov, S; Rodozov, M; Sultanov, G; Vutova, M; Dimitrov, A; Glushkov, I; Hadjiiska, R; Kozhuharov, V; Litov, L; Pavlov, B; Petkov, P; Bian, J G; Chen, G M; Chen, H S; Chen, M; Du, R; Jiang, C H; Liang, D; Liang, S; Meng, X; Plestina, R; Tao, J; Wang, X; Wang, Z; Asawatangtrakuldee, C; Ban, Y; Guo, Y; Li, Q; Li, W; Liu, S; Mao, Y; Qian, S J; Wang, D; Zhang, L; Zou, W; Avila, C; Chaparro Sierra, L F; Florez, C; Gomez, J P; Gomez Moreno, B; Sanabria, J C; Godinovic, N; Lelas, D; Polic, D; Puljak, I; Antunovic, Z; Kovac, M; Brigljevic, V; Kadija, K; Luetic, J; Mekterovic, D; Morovic, S; Tikvica, L; Attikis, A; Mavromanolakis, G; Mousa, J; Nicolaou, C; Ptochos, F; Razis, P A; Finger, M; Finger, M; Assran, Y; Elgammal, S; Ellithi Kamel, A; Mahmoud, M A; Mahrous, A; Radi, A; Kadastik, M; Müntel, M; Murumaa, M; Raidal, M; Tiko, A; Eerola, P; Fedi, G; Voutilainen, M; Härkönen, J; Karimäki, V; Kinnunen, R; Kortelainen, M J; Lampén, T; Lassila-Perini, K; Lehti, S; Lindén, T; Luukka, P; Mäenpää, T; Peltola, T; Tuominen, E; Tuominiemi, J; Tuovinen, E; Wendland, L; Tuuva, T; Besancon, M; Couderc, F; Dejardin, M; Denegri, D; Fabbro, B; Faure, J L; Ferri, F; Ganjour, S; Givernaud, A; Gras, P; Hamel de Monchenault, G; Jarry, P; Locci, E; Malcles, J; Nayak, A; Rander, J; Rosowsky, A; Titov, M; Baffioni, S; Beaudette, F; Busson, P; Charlot, C; Daci, N; Dahms, T; Dalchenko, M; Dobrzynski, L; Filipovic, N; Florent, A; Granier de Cassagnac, R; Mastrolorenzo, L; Miné, P; Mironov, C; Naranjo, I N; Nguyen, M; Ochando, C; Paganini, P; Sabes, D; Salerno, R; Sauvan, J B; Sirois, Y; Veelken, C; Yilmaz, Y; Zabi, A; Agram, J-L; Andrea, J; Bloch, D; Brom, J-M; Chabert, E C; Collard, C; Conte, E; Drouhin, F; Fontaine, J-C; Gelé, D; Goerlach, U; Goetzmann, C; Juillot, P; Le Bihan, A-C; Van Hove, P; Gadrat, S; Beauceron, S; Beaupere, N; Boudoul, G; Brochet, S; Carrillo Montoya, C A; Chasserat, J; Chierici, R; Contardo, D; Depasse, P; El Mamouni, H; Fan, J; Fay, J; Gascon, S; Gouzevitch, M; Ille, B; Kurca, T; Lethuillier, M; Mirabito, L; Perries, S; Ruiz Alvarez, J D; Sgandurra, L; Sordini, V; Vander Donckt, M; Verdier, P; Viret, S; Xiao, H; Tsamalaidze, Z; Autermann, C; Beranek, S; Bontenackels, M; Calpas, B; Edelhoff, M; Feld, L; Hindrichs, O; Klein, K; Ostapchuk, A; Perieanu, A; Raupach, F; Sammet, J; Schael, S; Sprenger, D; Weber, H; Wittmer, B; Zhukov, V; Ata, M; Caudron, J; Dietz-Laursonn, E; Duchardt, D; Erdmann, M; Fischer, R; Güth, A; Hebbeker, T; Heidemann, C; Hoepfner, K; Klingebiel, D; Knutzen, S; Kreuzer, P; Merschmeyer, M; Meyer, A; Olschewski, M; Padeken, K; Papacz, P; Reithler, H; Schmitz, S A; Sonnenschein, L; Teyssier, D; Thüer, S; Weber, M; Cherepanov, V; Erdogan, Y; Flügge, G; Geenen, H; Geisler, M; Haj Ahmad, W; Hoehle, F; Kargoll, B; Kress, T; Kuessel, Y; Lingemann, J; Nowack, A; Nugent, I M; Perchalla, L; Pooth, O; Stahl, A; Asin, I; Bartosik, N; Behr, J; Behrenhoff, W; Behrens, U; Bell, A J; Bergholz, M; Bethani, A; Borras, K; Burgmeier, A; Cakir, A; Calligaris, L; Campbell, A; Choudhury, S; Costanza, F; Diez Pardos, C; Dooling, S; Dorland, T; Eckerlin, G; Eckstein, D; Eichhorn, T; Flucke, G; Geiser, A; Grebenyuk, A; Gunnellini, P; Habib, S; Hauk, J; Hellwig, G; Hempel, M; Horton, D; Jung, H; Kasemann, M; Katsas, P; Kieseler, J; Kleinwort, C; Krämer, M; Krücker, D; Lange, W; Leonard, J; Lipka, K; Lohmann, W; Lutz, B; Mankel, R; Marfin, I; Melzer-Pellmann, I-A; Meyer, A B; Mnich, J; Mussgiller, A; Naumann-Emme, S; Novgorodova, O; Nowak, F; Ntomari, E; Perrey, H; Petrukhin, A; Pitzl, D; Placakyte, R; Raspereza, A; Ribeiro Cipriano, P M; Riedl, C; Ron, E; Sahin, M Ö; Salfeld-Nebgen, J; Saxena, P; Schmidt, R; Schoerner-Sadenius, T; Schröder, M; Stein, M; Vargas Trevino, A D R; Walsh, R; Wissing, C; Aldaya Martin, M; Blobel, V; Enderle, H; Erfle, J; Garutti, E; Goebel, K; Görner, M; Gosselink, M; Haller, J; Höing, R S; Kirschenmann, H; Klanner, R; Kogler, R; Lange, J; Lapsien, T; Lenz, T; Marchesini, I; Ott, J; Peiffer, T; Pietsch, N; Rathjens, D; Sander, C; Schettler, H; Schleper, P; Schlieckau, E; Schmidt, A; Seidel, M; Sibille, J; Sola, V; Stadie, H; Steinbrück, G; Troendle, D; Usai, E; Vanelderen, L; Barth, C; Baus, C; Berger, J; Böser, C; Butz, E; Chwalek, T; De Boer, W; Descroix, A; Dierlamm, A; Feindt, M; Guthoff, M; Hartmann, F; Hauth, T; Held, H; Hoffmann, K H; Husemann, U; Katkov, I; Kornmayer, A; Kuznetsova, E; Lobelle Pardo, P; Martschei, D; Mozer, M U; Müller, Th; Niegel, M; Nürnberg, A; Oberst, O; Quast, G; Rabbertz, K; Ratnikov, F; Röcker, S; Schilling, F-P; Schott, G; Simonis, H J; Stober, F M; Ulrich, R; Wagner-Kuhr, J; Wayand, S; Weiler, T; Wolf, R; Zeise, M; Anagnostou, G; Daskalakis, G; Geralis, T; Kesisoglou, S; Kyriakis, A; Loukas, D; Markou, A; Markou, C; Psallidas, A; Topsis-Giotis, I; Gouskos, L; Panagiotou, A; Saoulidou, N; Stiliaris, E; Aslanoglou, X; Evangelou, I; Flouris, G; Foudas, C; Jones, J; Kokkas, P; Manthos, N; Papadopoulos, I; Paradas, E; Bencze, G; Hajdu, C; Hidas, P; Horvath, D; Sikler, F; Veszpremi, V; Vesztergombi, G; Zsigmond, A J; Beni, N; Czellar, S; Molnar, J; Palinkas, J; Szillasi, Z; Karancsi, J; Raics, P; Trocsanyi, Z L; Ujvari, B; Swain, S K; Beri, S B; Bhatnagar, V; Dhingra, N; Gupta, R; Kaur, M; Mittal, M; Nishu, N; Sharma, A; Singh, J B; Kumar, Ashok; Kumar, Arun; Ahuja, S; Bhardwaj, A; Choudhary, B C; Kumar, A; Malhotra, S; Naimuddin, M; Ranjan, K; Sharma, V; Shivpuri, R K; Banerjee, S; Bhattacharya, S; Chatterjee, K; Dutta, S; Gomber, B; Jain, Sa; Jain, Sh; Khurana, R; Modak, A; Mukherjee, S; Roy, D; Sarkar, S; Sharan, M; Singh, A P; Abdulsalam, A; Dutta, D; Kailas, S; Kumar, V; Mohanty, A K; Pant, L M; Shukla, P; Topkar, A; Aziz, T; Chatterjee, R M; Ganguly, S; Ghosh, S; Guchait, M; Gurtu, A; Kole, G; Kumar, S; Maity, M; Majumder, G; Mazumdar, K; Mohanty, G B; 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Hughes, R; Kotov, K; Ling, T Y; Puigh, D; Rodenburg, M; Smith, G; Vuosalo, C; Winer, B L; Wolfe, H; Wulsin, H W; Berry, E; Elmer, P; Halyo, V; Hebda, P; Hunt, A; Jindal, P; Koay, S A; Lujan, P; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Piroué, P; Quan, X; Raval, A; Saka, H; Stickland, D; Tully, C; Werner, J S; Zenz, S C; Zuranski, A; Brownson, E; Lopez, A; Mendez, H; Ramirez Vargas, J E; Alagoz, E; Benedetti, D; Bolla, G; Bortoletto, D; De Mattia, M; Everett, A; Hu, Z; Jha, M K; Jones, M; Jung, K; Kress, M; Leonardo, N; Lopes Pegna, D; Maroussov, V; Merkel, P; Miller, D H; Neumeister, N; Radburn-Smith, B C; Shipsey, I; Silvers, D; Svyatkovskiy, A; Wang, F; Xie, W; Xu, L; Yoo, H D; Zablocki, J; Zheng, Y; Parashar, N; Adair, A; Akgun, B; Ecklund, K M; Geurts, F J M; Li, W; Michlin, B; Padley, B P; Redjimi, R; Roberts, J; Zabel, J; Betchart, B; Bodek, A; Covarelli, R; de Barbaro, P; Demina, R; Eshaq, Y; Ferbel, T; Garcia-Bellido, A; Goldenzweig, P; Han, J; Harel, A; Miner, D C; Petrillo, G; Vishnevskiy, D; Zielinski, M; Bhatti, A; Ciesielski, R; Demortier, L; Goulianos, K; Lungu, G; Mesropian, C; Arora, S; Barker, A; Chou, J P; Contreras-Campana, C; Contreras-Campana, E; Duggan, D; Ferencek, D; Gershtein, Y; Gray, R; Halkiadakis, E; Hidas, D; Lath, A; Panwalkar, S; Park, M; Patel, R; Rekovic, V; Robles, J; Salur, S; Schnetzer, S; Seitz, C; Somalwar, S; Stone, R; Thomas, S; Thomassen, P; Walker, M; Rose, K; Spanier, S; Yang, Z C; York, A; Bouhali, O; Eusebi, R; Flanagan, W; Gilmore, J; Kamon, T; Khotilovich, V; Krutelyov, V; Montalvo, R; Osipenkov, I; Pakhotin, Y; Perloff, A; Roe, J; Safonov, A; Sakuma, T; Suarez, I; Tatarinov, A; Toback, D; Akchurin, N; Cowden, C; Damgov, J; Dragoiu, C; Dudero, P R; Faulkner, J; Kovitanggoon, K; Kunori, S; Lee, S W; Libeiro, T; Volobouev, I; Appelt, E; Delannoy, A G; Greene, S; Gurrola, A; Johns, W; Maguire, C; Melo, A; Sharma, M; Sheldon, P; Snook, B; Tuo, S; Velkovska, J; Arenton, M W; Boutle, S; Cox, B; Francis, B; Goodell, J; Hirosky, R; Ledovskoy, A; Li, H; Lin, C; Neu, C; Wood, J; Gollapinni, S; Harr, R; Karchin, P E; Kottachchi Kankanamge Don, C; Lamichhane, P; Belknap, D A; Borrello, L; Carlsmith, D; Cepeda, M; Dasu, S; Duric, S; Friis, E; Grothe, M; Hall-Wilton, R; Herndon, M; Hervé, A; Klabbers, P; Klukas, J; Lanaro, A; Lazaridis, C; Levine, A; Loveless, R; Mohapatra, A; Ojalvo, I; Perry, T; Pierro, G A; Polese, G; Ross, I; Sarangi, T; Savin, A; Smith, W H; Woods, N

Measurements are reported of the WZ and ZZ production cross sections in proton-proton collisions at [Formula: see text][Formula: see text] in final states where one Z boson decays to b-tagged jets. The other gauge boson, either W or Z, is detected through its leptonic decay (either [Formula: see text], [Formula: see text] or [Formula: see text], [Formula: see text], or [Formula: see text]). The results are based on data corresponding to an integrated luminosity of 18.9 fb[Formula: see text] collected with the CMS detector at the Large Hadron Collider. The measured cross sections, [Formula: see text] and [Formula: see text], are consistent with next-to-leading order quantum chromodynamics calculations.

Modified ring stretch tensile testing of Zr-1Nb cladding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, A.B.; Majumdar, S.; Ruther, W.E.

1998-03-01

In a round robin effort between the US Nuclear Regulatory Commission, Institut de Protection et de Surete Nucleaire in France, and the Russian Research Centre-Kurchatov Institute, Argonne National Laboratory conducted 16 modified ring stretch tensile tests on unirradiated samples of zr-1Nb cladding, which is used in Russian VVER reactors. Test were conducted at two temperatures (25 and 400 C) and two strain rates (0.001 and 1 s{sup {minus}1}). At 25 C and 0.001 s{sup {minus}1}, the yield strength (YS), ultimate tensile strength (UTS), uniform elongation (UE), and total elongation (TE) were 201 MPa, 331 MPa, 18.2%, and 57.6%, respectively. Atmore » 400 C and 0.001 s{sup {minus}1}, the YS, UTS, UE, and TE were 109 MPa, 185 MPa, 15.4%, and 67.7%, respectively. Finally, at 400 C and 1 s{sup {minus}1}, the YS, UTS, UE, and TE were 134 MPa, 189 MPa, 18.9%, and 53.4%, respectively. The high strain rate tests at room temperature were not successful. Test results proved to be very sensitive to the amount of lubrication used on the inserts; because of the large contact area between the inserts and specimen, too little lubrication leads to significantly higher strengths and lower elongations being reported. It is also important to note that only 70 to 80% of the elongation takes place in the gauge section, depending on specimen geometry. The appropriate percentage can be estimated from a simple model or can be calculated from finite-element analysis.« less

Lead Poisoning and Anemia Associated with Use of Ayurvedic Medications Purchased on the Internet--Wisconsin, 2015.

PubMed

Meiman, Jon; Thiboldeaux, Robert; Anderson, Henry

2015-08-21

On April 30, 2015, the Wisconsin Division of Public Health (WDPH) was notified by a local health department of an elevated blood lead level (BLL) in a female patient aged 64 years. All Wisconsin laboratories are required to provide BLL testing results performed on any state resident to WDPH, and WDPH and local health departments are statutorily mandated to investigate any single BLL ≥20 µg/dL or BLLs that are persistently ≥15 µg/dL. Review of medical records revealed that the patient had developed progressive fatigue and shortness of breath during a period of multiple weeks that prompted inpatient medical evaluation. Hemoglobin level was 8.3 g/dL (normal range for age and sex of patient = 12.5-15.0 g/dL), and peripheral blood smear showed normochromic, normocytic red blood cells with basophilic stippling. A BLL was obtained and found to be 85.8 µg/dL. Urine toxic metals tests revealed mercury and aluminum levels in the normal range. Combined methylated and inorganic urine arsenic levels were slightly elevated at 53.3 µg/L (normal = <18.9 µg/L). The patient was discharged for outpatient lead chelation therapy with oral meso-2,3-dimercaptosuccinic acid.

Determining the Sensitivity of CAT-ASVAB (Computerized Adaptive Testing- Armed Services Vocational Aptitude Battery) Scores to Changes in Item Response Curves with the Medium of Administration

DTIC Science & Technology

1986-08-01

most examinees. Therefore it appears psychometrically ac - ceptable for the CAT -ASVAB project to proceed without item recalibration based on...MEMORANDUM DETERMINING THE SENSITIVITY OF CAT -ASVAB SCORES TO CHANGES IN ITEM RESPONSE CURVES WITH THE MEDIUM OF ADMINISTRATION D. R. Divgi...Subj: Center for Naval Analyses Research Memorandum 86-189 End: (1) CNA Research Memorandum 86-189, "Determining the Sensitivity of CAT -ASVAB

SU-F-I-56: High-Precision Gamma-Ray Analysis of Medical Isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chopra, N; Chillery, T; Chowdhury, P

2016-06-15

Purpose: Advanced, time-resolved, Compton-suppressed gamma-ray spectroscopy with germanium detectors is implemented for assaying medical isotopes to study the radioactive decay process leading to a more accurate appraisal of the received dose and treatment planning. Lowell’s Array for Radiological Assay (LARA), a detector array that is comprised of six Compton-suppressed high-purity germanium detectors, is currently under development at UMass-Lowell which combines Compton-suppression and time-and-angle correlations to allow for highly efficient and highly sensitive measurements. Methods: Two isotopes produced Brookhaven Linac Isotope Producer (BLIP) were investigated. {sup 82}Sr which is the parent isotope for producing {sup 82}Rb is often used in cardiacmore » PET. {sup 82}Sr gamma-ray spectrum is dominated by the 511keV photons from positron annihilation which prevent precise measurement of co-produced contaminant isotopes. A second project was to investigate the production of platinum isotopes. Natural platinum was bombarded with protons from 53MeV to 200MeV. The resulting spectrum was complicated due to the large number of stable platinum isotopes in the target, the variety of open reaction channels (p,xn), (p,pxn), (p,axn). Results: By using face-to-face NaI(Tl) counters 90-degrees to the Compton-suppressed germaniums to detect the 511keV photons, a much cleaner and more sensitive measurement of {sup 85}Sr and other contaminants was obtained. For the platinum target, we identified the production of {sup 188–189–191–195}Pt, {sup 191–192–193–194–195–196}Au and {sup 186–188–189–190–192–194–189–190–192–194}Ir. For example, at the lower energies (53 and 65MeV), we measured {sup 191}Pt production cross-sections of 144mb and 157mb. Considerable care was needed in following the process of dissolving and diluting the samples to get consistent results. The new LARA array will help us better ascertain the absolute efficiency of the counting system and more reliable production cross-sections. Conclusion: Modern HPGe spectroscopic techniques provide enhanced sensitivity, promising precise quantification of the quality of radioisotopes used in medical physics. Using new decay information may have non-trivial impact on treatment planning and dose-assessment.« less

[Analysis of surgical treatment with pectoralis major muscle flap for deep sternal infection after cardiac surgery: a case series of 189 patients].

PubMed

Liu, Dong; Wang, Wenzhang; Cai, Aibing; Han, Zhiyi; Li, Xiyuan; Ma, Jiagui

2015-03-01

To analyze and summarize the clinical features and experience in surgical treatment of deep sternal infection (DSWI). This was a retrospective study. From January 2008 to December 2013, 189 patients with secondary DSWI after cardiac surgery underwent the pectoralis major muscle flap transposition in our department. There were 116 male and 73 female patients. The mean age was (54 ± 21) years, the body mass index was (26. 1 ± 1. 3) kg/m2. The incidence of postoperation DSWI were after isolated coronary artery bypass grafting (CABG) in 93 patients, after other heart surgery plus CABG in 13 patients, after valve surgery in 47 patients, after thoracic aortic surgery in 16 patients, after congenital heart disease in 18 patients, and after cardiac injury in 2 patients. Clean patients' wound and extract secretions, clear the infection thoroughly by surgery and select antibiotics based on susceptibility results, and then repair the wound with appropriate muscle flap, place drain tube with negative pressure. Of all the 189 patients, 184 used isolate pectoralis, 1 used isolate rectus, and 4 used pectoralis plus rectus. The operative wounds of 179 patients were primary healing (94. 7%). Hospital discharge was postponed by 1 week for 7 patients, due to subcutaneous wound infection. Subcutaneous wound infection occurred again in 8 patients 1 week after hospital discharge, and their wounds healed after wound dressing. Nine patients (4. 7%) did not recover, due to residue of the sequestrum and costal chondritis, whom were later cured by undergoing a second treatment of debridement and pectoralis major muscle flap transposition. Eight patients died, in which 2 died of respiratory failure, 2 died of bacterial endocarditis with septicemia, 2 died of renal failure, 1 died of intraoperative bleeding leading to brain death and the 1 died of heart failure. The mortality rate was 4. 2% . The average length of postoperative hospital stay was (14 ± 5) days. The longest postoperative follow-up period was 40 months, the median time was 26 months, the follow-up rate was 83. 9% . Totally 179 patients were no-reinfected, 2 patients were reinfected because of artificial vascular rejection. To perform surgical debridement and then reconstruct the sternal defect with pectoralis major muscle flap actively for the patient is an effective measure to improve patient's survival rate.

Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.

PubMed Central

Kinsella, B T; Erdman, R A; Maltese, W A

1991-01-01

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-carbon geranylgeranyl groups within a Cys-Ali-Ali-Leu motif. We changed the terminal Ser-189 of Ha-ras p21 to Leu-189 by site-directed mutagenesis and found that the protein was modified by [3H]geranylgeranyl instead of [3H]farnesyl in an in vitro assay. Gel-permeation chromatography of [3H]mevalonate-labeled hydrocarbons released from immunoprecipitated ras proteins overexpressed in COS cells indicated that Ha-ras p21(Leu-189) was also a substrate for 20-carbon isoprenyl modification in vivo. Additional steps in Ha-ras p21 processing, normally initiated by farnesylation, appear to be supported by geranylgeranylation, based on metabolic labeling of Ha-ras p21(Leu-189) with [3H]palmitate and its subcellular localization in a particulate fraction from COS cells. These observations indicate that the amino acid occupying the terminal position (Xaa) in the Cys-Ali-Ali-Xaa motif constitutes a key structural feature by which Ha-ras p21 and other proteins with ras-like COOH-terminal isoprenylation sites are distinguished as substrates for farnesyl- or geranylgeranyltransferases. Images PMID:1924354

Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kinsella, B.T.; Erdman, R.A.; Maltese, W.A.

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-carbon geranylgeranyl groups within a Cys-Ali-Ali-Leu motif. The authors changed the terminal Ser-189 of Ha-ras p21 to Leu-189 by site-directed mutagenesis and found that the protein was modified by ({sup 3}H)geranylgeranyl instead of ({sup 3}H)farnesyl in an in vitro assay. Gel-permeation chromatography of ({sup 3}H)mevalonate-labeled hydrocarbons released from immunoprecipitated ras proteins overexpressed in COS cells indicated that Ha-ras p21 (Leu-189) wasmore » also a substrate for 20-carbon isoprenyl modification in vivo. Additional steps in Ha-ras p21 processing, normally initiated by farnesylation, appear to be supported by geranylgeranylation, based on metabolic labeling of Ha-ras p21 (Leu-189) with ({sup 3}H) palmitate and its subcellular localization in a particulate fraction from COS cells. These observations indicate that the amino acid occupying the terminal position (Xaa) in the Cys-Ali-Ali-Xaa motif constitutes a key structural feature by which Ha-ras p21 and other proteins with ras-like COOH-terminal isoprenylation sites are distinguished as substrates for farnesyl- or geranylgeranyltransferases.« less

Lead and cadmium in some cereal products on the Finnish market 1990-91.

PubMed

Tahvonen, R; Kumpulainen, J

1993-01-01

Lead and cadmium contents were determined in representatively collected (commercial mills, wholesalers) samples of rye flour, breakfast cereals, porridge flakes, muesli cereals and pasta products. The samples were digested by heating them overnight in concentrated HNO3. Lead and cadmium concentrations were determined by GFAAS using a platform and (NH4)H2PO4 as a matrix modifier. ARC/CL coded wheat flour and other reference materials (NBS 1567a, BCR no. 189, BCR no. 191) were employed for the analytical quality control. Lead and cadmium contents found in the above samples were generally much lower than the present tolerance limits in Finland (300 micrograms/kg and 100 micrograms/kg respectively). The mean cadmium and lead contents of rye flours studied were very low, being 9 micrograms/kg and 16 micrograms/kg respectively. The mean contents of lead and cadmium in wheat-based breakfast cereals were 22 and 42, in rye products 19 and 26, in oats 17 and 2, in maize products 11 and 18 and in rice products 31 and 10 micrograms/kg, respectively. The mean contents of lead and cadmium in muesli cereals were 34 and 27 micrograms/kg. Remarkably high cadmium contents were found in some pastas made from imported durum wheat. The mean cadmium content of all past products was 79 micrograms/kg with a range of 26-182 micrograms/kg. Lead contents were low, with a mean of 18 micrograms/kg, and a range of 8 to 66 micrograms/kg. Cereals contribute about 59% of the average total dietary cadmium intake in Finland. Nearly 60% of the total cereal consumption is wheat and 27% rye. Since rye has a lower cadmium content than wheat, rye is preferable to wheat. About 15% of lead is derived from cereals. As the total intake of heavy metals is very low in Finland, there is no need to alter cereal consumption.

Working smarter on cold cases: identifying factors associated with successful cold case investigations.

PubMed

Davis, Robert C; Jensen, Carl J; Burgette, Lane; Burnett, Kathryn

2014-03-01

Cold case squads have garnered much attention; however, they have yet to undergo significant empirical scrutiny. In the present study, the authors interviewed investigators and reviewed 189 solved and unsolved cold cases in Washington, D.C., to determine whether there are factors that can predict cold case solvability. In the interviews, new information from witnesses or information from new witnesses was cited as the most prevalent reason for case clearance. The case reviews determined that there were factors in each of the following domains that predicted whether cases would be solved during cold case investigations: Crime Context, Initial Investigation Results, Basis for Opening Cold Case, and Cold Case Investigator Actions. The results suggest that it is possible to prioritize cold case work based on the likelihood of investigations leading to clearances. © 2014 American Academy of Forensic Sciences.

Cyclotron production of Ga-68 for human use from liquid targets: From theory to practice

NASA Astrophysics Data System (ADS)

Alves, F.; Alves, V. H.; Neves, A. C. B.; do Carmo, S. J. C.; Nactergal, B.; Hellas, V.; Kral, E.; Gonçalves-Gameiro, C.; Abrunhosa, A. J.

2017-05-01

A fully automated system for the production of 68Ga based on commercially available cyclotron liquid target and synthesis modules is described. A solution containing enriched 68Zn dissolved in a nitric solution is irradiated in a Cyclone 18/9 IBA cyclotron leading to the production of up to about 25 GBq of 68Ga. The irradiated solution is transferred to a Synthera synthesis module in which 68Ga is separated and purified with a yield superior to 85 % and where further labelling is achieved with yields no inferior to 70 %. The developed and implemented method presents an improved approach for the production of 68Ga-radiopharmaceuticals suitable for human use, in a process that takes less than 2 hours. This technique represents an economically viable alternative to 68Ge/68Ga generators with improved characteristics.

The Good Appraisal Toolkit for Primary Care Chambers Ruth et al The Good Appraisal Toolkit for Primary Care 189pp Radcliffe Publishing 9781857756029 1857756029.

PubMed

2005-03-02

The principles and frameworks demonstrated in this book could be used in many other healthcare settings. The text is divided neatly into nine chapters and addresses practical issues such as being an effective appraiser, developing and demonstrating competence, linking appraisal with career development, and evaluation of the appraisal process. The comprehensive approach to all aspects of appraisal makes this a must-have book for all health professionals and managers undertaking appraisals. It should also appeal to clinical governance leads and individuals being appraised. There are excellent tips on how to prepare for appraisals and how to link this with reflection, lifelong learning, career direction, and so on. The book is well referenced and contains an appendix with useful examples for the appraiser.

Changes in the mean square charge radii and electromagnetic moments of neutron-deficient Bi isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barzakh, A. E., E-mail: barzakh@mail.ru; Batist, L. Kh.; Fedorov, D. V.

In-source laser spectroscopy experiments for neutron deficient bismuth isotopes at the 306.77 nm atomic transition were carried out at the IRIS (Investigation of Radioactive Isotopes on Synchrocyclotron) facility of Petersburg Nuclear Physics Institute (PNPI). New data on isotope shifts and hyperfine structure for {sup 189–198,} {sup 211}Bi isotopes and isomers were obtained. The changes in the mean-square charge radii and the magnetic moment values were deduced. Marked deviation from the nearly spherical behavior for ground states of bismuth isotopes at N < 109 is demonstrated, in contrast to the lead and thallium isotopic chains. The big isomer shift between Imore » = 1/2 (intruder) and I = 9/2 (normal) states for odd Bi isotopes (A = 193, 195, 197) was found.« less

Remedial Investigation for Base Closure, Remedial Investigation/Feasibility Study, Army Materials Technology Laboratory, Watertown, Massachusetts, Phase 2. Volume 2. Tables

DTIC Science & Technology

1994-05-01

g & 4) 2O 0) oo CK 0 ca * Co to ; o > -3 0pq ~ ~ .a) 0 0 -Wj ý*4 S a))C 4- sI a) a T-2 II, - + . iU+ • I ! -,_ .i ~£ . $ , .. + ! *1+ e * U S 8 a...T-37 I m beq Si °,i 0 4 0 0* 0 .55C - II T-38I U I T-3I~ 00 - e 011.4~ 0 CI * I] * ( -C iC oc m -4 I T-39 w mINI G) .2 ) ( T-40 pm...4440 -416- 14800 Chromium 11.1 22.7 26.8 337 Cobalt 4.69 7. 14 6.87 Copper 14.7 322 18.9 154 3928Iron 12800 194000 60 38100 26600 Lead 10.1 259 11.9 3

BARNARD 59: NO EVIDENCE FOR FURTHER FRAGMENTATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roman-Zuniga, C. G.; Frau, P.; Girart, J. M.

2012-03-10

The dense molecular clump at the center of the Barnard 59 (B59) complex is the only region in the Pipe Nebula that has formed a small, stellar cluster. The previous analysis of a high-resolution near-IR dust extinction map revealed that the nuclear region in B59 is a massive, mostly quiescent clump of 18.9 M{sub Sun }. The clump shows a monolithic profile, possibly indicating that the clump is on the way to collapse, with no evident fragmentation that could lead to another group of star systems. In this paper, we present new analysis that compares the dust extinction map withmore » a new dust emission radio-continuum map of higher spatial resolution. We confirm that the clump does not show any significant evidence for prestellar fragmentation at scales smaller than those probed previously.« less

1976 annual summary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-03-01

Abstracts of papers published during the previous calendar year, arranged in accordance with the project titles used in the USDOE Schedule 189 Budget Proposals, are presented. The collection of abstracts supplements the listing of papers published in the Schedule 189. The following subject areas are represented: high-energy physics; nuclear physics; basic energy sciences (nuclear science, materials sciences, solid state physics, materials chemistry); molecular, mathematical, and earth sciences (fundamental interactions, processes and techniques, mathematical and computer sciences); environmental research and development; physical and technological studies (characterization, measurement and monitoring); and nuclear research and applications.

Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk

PubMed Central

Rohmah, Rista Nikmatu; Hardiyanti, Ferlany; Fatchiyah, Fatchiyah

2015-01-01

Background: RA is a systemic inflammatory disease that causes developing comorbidity conditions. This condition can cause by overproduction of pro-inflammatory cytokine. In a previous study, we have found bioactive peptide CSN1S2 from Ethawah goat milk for anti-inflammatory for repair the ileum destruction. However, the signaling transduction cascade of bioactive peptides inhibits inflammation still not clear yet. Therefore, we analyzed the signaling transduction cascade via JAK-STAT3 pathway by in vivo and in silico. Methods: The ileum was isolated DNA and amplification with specific primer. The sequence was analyzed using the Sanger sequencing method. Modeling 3D-structure was predicted by SWISS-MODEL and virtual interaction was analyzed by docking system using Pymol and Discovery Studio 4.0 software. Results: This study showed that STAT3 has target gene 480bp. The normal group and normal treating- CSN1S2 of goat milk have similarity from gene bank. Whereas, RA group had transversion mutation that the purine change into pyrimidine even cause frameshift mutation. Interestingly, after treating with the CSN1S2 protein of goat milk shows reverse to the normal acid sequence group. Based on in silico study, from eight peptides, only three peptides of CSN1S2 protein, which carried by PePT1 to enter the small intestine. The fragments are PepT1-41-NMAIHPR-47; PepT1-182-KISQYYQK-189 and PepT1-214-TNAIPYVR-221. We have found just one bioactive peptide of f182-KISQYYQK-189 is able bind to STAT3. The energy binding of f182-KISQYYQK-189 and RA-STAT3 amino acid, it was Σ = -402.43 kJ/mol and the energy binding of f182-KISQYYQK-189 and RAS-STAT3 amino acid is decreasing into Σ = -407.09 kJ/mol. Conclusion: This study suggested that the fragment 182-KISQYYQK-189 peptides from Ethawah goat milk may act as an anti-inflammatory agent via JAK-STAT3 signal transduction cascade at the cellular level. PMID:26483598

Comparison of PCR primer-based strategies for characterization of ammonia oxidizer communities in environmental samples.

PubMed

Mahmood, Shahid; Freitag, Thomas E; Prosser, James I

2006-06-01

PCR-based techniques are commonly used to characterize microbial communities, but are subject to bias that is difficult to assess. This study aimed to evaluate bias of several PCR primer-based strategies used to study diversity of autotrophic ammonia oxidizers. 16S rRNA genes from soil- or sediment-DNA were amplified using primers considered either selective or specific for betaproteobacterial ammonia oxidizers. Five approaches were assessed: (a) amplification with primers betaAMO143f-betaAMO1315r; (b) amplification with primers CTO189f-CTO654r; (c) nested amplification with betaAMO143f-betaAMO1315r followed by CTO189f-CTO654r primers; (d) nested amplification with betaAMO143f-betaAMO1315r and CTO189f-Pf1053r primers; (e) nested amplification with 27f-1492r and CTO189f-CTO654r primers. Amplification products were characterized by denaturing gradient gel electrophoresis (DGGE) analysis after further amplification with 357f-GC-518r primers. DGGE profiles of soil communities were heterogeneous and depended on the approach followed. Ammonia oxidizer diversity was higher using approaches (b), (c) and (e) than using (a) and (d), where sequences of the most prominent bands showed similarities to nonammonia oxidizers. Profiles from marine sediments were more consistent, regardless of the approach adopted, and sequence analysis of excised bands indicated that these consisted of ammonia oxidizers only. The study demonstrates the importance of choice of primer, of screening for sequences of nontarget organisms and use of several approaches when characterizing microbial communities in natural environments.

A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.

PubMed

Kaya, Ali I; Lokits, Alyssa D; Gilbert, James A; Iverson, T M; Meiler, Jens; Hamm, Heidi E

2016-09-09

G protein-coupled receptor-mediated heterotrimeric G protein activation is a major mode of signal transduction in the cell. Previously, we and other groups reported that the α5 helix of Gαi1, especially the hydrophobic interactions in this region, plays a key role during nucleotide release and G protein activation. To further investigate the effect of this hydrophobic core, we disrupted it in Gαi1 by inserting 4 alanine amino acids into the α5 helix between residues Gln(333) and Phe(334) (Ins4A). This extends the length of the α5 helix without disturbing the β6-α5 loop interactions. This mutant has high basal nucleotide exchange activity yet no receptor-mediated activation of nucleotide exchange. By using structural approaches, we show that this mutant loses critical hydrophobic interactions, leading to significant rearrangements of side chain residues His(57), Phe(189), Phe(191), and Phe(336); it also disturbs the rotation of the α5 helix and the π-π interaction between His(57) and Phe(189) In addition, the insertion mutant abolishes G protein release from the activated receptor after nucleotide binding. Our biochemical and computational data indicate that the interactions between α5, α1, and β2-β3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (or GDP rebinding). Thus, our studies suggest that this hydrophobic interface is critical for accurate rearrangement of the α5 helix for G protein release from the receptor after GTP binding. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Safety of a condom uterine balloon tamponade (ESM-UBT) device for uncontrolled primary postpartum hemorrhage among facilities in Kenya and Sierra Leone.

PubMed

Ramanathan, Aparna; Eckardt, Melody J; Nelson, Brett D; Guha, Moytrayee; Oguttu, Monica; Altawil, Zaid; Burke, Thomas

2018-05-15

Postpartum hemorrhage is the leading cause of maternal mortality in low- and middle-income countries. While evidence on uterine balloon tamponade efficacy for severe hemorrhage is encouraging, little is known about safety of this intervention. The objective of this study was to evaluate the safety of an ultra-low-cost uterine balloon tamponade package (named ESM-UBT) for facility-based management of uncontrolled postpartum hemorrhage (PPH) in Kenya and Sierra Leone. Data were collected on complications/adverse events in all women who had an ESM-UBT device placed among 92 facilities in Sierra Leone and Kenya, between September 2012 and December 2015, as part of a multi-country study. Three expert maternal health investigator physicians analyzed each complication/adverse event and developed consensus on whether there was a potential causal relationship associated with use of the ESM-UBT device. Adverse events/complications specifically investigated included death, hysterectomy, uterine rupture, perineal or cervical injury, serious or minor infection, and latex allergy/anaphylaxis. Of the 201 women treated with an ESM-UBT device in Kenya and Sierra Leone, 189 (94.0%) survived. Six-week or longer follow-up was recorded in 156 of the 189 (82.5%). A causal relationship between use of an ESM-UBT device and one death, three perineal injuries and one case of mild endometritis could not be completely excluded. Three experts found a potential association between these injuries and an ESM-UBT device highly unlikely. The ESM-UBT device appears safe for use in women with uncontrolled PPH. Trial registration was not completed as data was collected as a quality assurance measure for the ESM-UBT kit.

Demonstration of helicase activity in the nonstructural protein, NSs, of the negative-sense RNA virus, groundnut bud necrosis virus.

PubMed

Bhushan, Lokesh; Abraham, Ambily; Choudhury, Nirupam Roy; Rana, Vipin Singh; Mukherjee, Sunil Kumar; Savithri, Handanahal Subbarao

2015-04-01

The nonstructural protein NSs, encoded by the S RNA of groundnut bud necrosis virus (GBNV) (genus Tospovirus, family Bunyaviridae) has earlier been shown to possess nucleic-acid-stimulated NTPase and 5' α phosphatase activity. ATP hydrolysis is an essential function of a true helicase. Therefore, NSs was tested for DNA helicase activity. The results demonstrated that GBNV NSs possesses bidirectional DNA helicase activity. An alanine mutation in the Walker A motif (K189A rNSs) decreased DNA helicase activity substantially, whereas a mutation in the Walker B motif resulted in a marginal decrease in this activity. The parallel loss of the helicase and ATPase activity in the K189A mutant confirms that NSs acts as a non-canonical DNA helicase. Furthermore, both the wild-type and K189A NSs could function as RNA silencing suppressors, demonstrating that the suppressor activity of NSs is independent of its helicase or ATPase activity. This is the first report of a true helicase from a negative-sense RNA virus.

Pentahydroxyscirpene—Producing Strains, Formation In Planta, and Natural Occurrence

PubMed Central

Varga, Elisabeth; Wiesenberger, Gerlinde; Fruhmann, Philipp; Malachová, Alexandra; Svoboda, Thomas; Lemmens, Marc; Adam, Gerhard; Berthiller, Franz

2016-01-01

Trichothecenes are a class of structurally diverse mycotoxins with more than 200 naturally occurring compounds. Previously, a new compound, pentahydroxyscirpene (PHS), was reported as a byproduct of a nivalenol producing Fusarium strain, IFA189. PHS contains a hydroxy group at C-8 instead of the keto group of type B trichothecenes. In this work, we demonstrate that IFA189 belongs to the species Fusarium kyushuense using molecular tools. Production of PHS in vitro was also observed for several isolates of other Fusarium species producing nivalenol. Furthermore, we report the formation of 4-acetyl-PHS by F. kyushuense on inoculated rice. Wheat ears of the variety Remus were infected with IFA189 and the in planta production of PHS was confirmed. Natural occurrence of PHS was verified in barley samples from the Czech Republic using a liquid chromatographic-tandem mass spectrometric method validated for this purpose. Toxicity of PHS to wheat ribosomes was evaluated with a coupled in vitro transcription and translation assay, which showed that PHS inhibits protein biosynthesis slightly less than nivalenol and deoxynivalenol. PMID:27754401

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing.

PubMed

Lord, Megan S; Ellis, April L; Farrugia, Brooke L; Whitelock, John M; Grenett, Hernan; Li, Chuanyu; O'Grady, Robert L; DeCarlo, Arthur A

2017-03-28

The repair of dermal wounds, particularly in the diabetic population, poses a significant healthcare burden. The impaired wound healing of diabetic wounds is attributed to low levels of endogenous growth factors, including vascular endothelial growth factor (VEGF), that normally stimulate multiple phases of wound healing. In this study, chitosan scaffolds were prepared via freeze drying and loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed in vivo for their ability to promote dermal wound healing. The plasmid DNA encoding perlecan domain I and VEGF189 loaded scaffolds promoted dermal wound healing in normal and diabetic rats. This treatment resulted in an increase in the number of blood vessels and sub-epithelial connective tissue matrix components within the wound beds compared to wounds treated with chitosan scaffolds containing control DNA or wounded controls. These results suggest that chitosan scaffolds containing plasmid DNA encoding VEGF189 and perlecan domain I have the potential to induce angiogenesis and wound healing. Copyright © 2017 Elsevier B.V. All rights reserved.

Tobacco training in clinical social work graduate programs.

PubMed

Kleinfelder, JoAnn; Price, James H; Dake, Joseph A; Jordan, Timothy R; Price, Joy A

2013-08-01

The leading cause of preventable death, in the most vulnerable segments of society, whom social workers often counsel, is cigarette smoking. The purpose of this study was to assess tobacco smoking cessation training in clinical social work programs. A valid 21-item questionnaire was sent to the entire population of 189 clinical graduate social work programs identified by the Council on Social Work Education. A three-wave mailing process was used to maximize the return rate. Directors from 112 clinical social work programs returned completed questionnaires (61 percent). The majority (91 percent) of directors reported having never thought about offering formal smoking cessation training, and only nine of the programs (8 percent) currently provided formal smoking cessation education. The three leading barriers to offering smoking cessation education were as follows: not a priority (60 percent), not enough time (55 percent), and not required by the accrediting body (41 percent). These findings indicate that clinical social work students are not receiving standardized smoking cessation education to assist in improving the well-being of their clients. The national accrediting body for graduate clinical social work programs should consider implementing guidelines for smoking cessation training in the curriculums.

Characterization of the proton beam from an IBA Cyclone 18/9 with radiochromic film EBT2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sansaloni, F.; Lagares, J. I.; Arce, P.

2012-12-19

The use of radiochromic films is widespread in different areas of medical physics like radiotherapy and hadrontherapy; however, radiochromic films have been scarcely used in the characterization of proton or deuteron beams generated in biomedical cyclotrons. In this paper the radiochromic film EBT2 was used to study the beam size and the proton beam energy of an IBA Cyclone 18/9 cyclotron. The results indicate that the beam size can be easily measured at a very low expense; however, an accurate determination of the beam energy might require the implementation of certain experimental improvements.

Fatigue Strength of Welded Joints and Fatigue Strength of Welded Joints: A Review of the Literature to July 1, 1936

DTIC Science & Technology

1936-12-02

a1loying. The first part of this statement Is simple to under- - td and is along the lines suggested by our studies of beet effeet am " union 189"t pwpestie...38, Feb. 1931. 189. Hodge, J. C., Amer. Weld. Soc. Jnl. 9, 93-116, Oct. 1930. 190. Hawkins, H. W., Proc. Rugby Engg. Soc., 27, 41-65 (1), (1932-1933...Construction, Gosstroyizdat, Moscow, 1933, 43-46; All- Union Scientific Engg. Soc. Welders, Research Works on Welding, 1934, 163-171. 262. Iller, R. W. Autog

150 {mu}A 18F{sup -} target and beam port upgrade for the IBA 18/9 cyclotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stokely, M. H.; Peeples, J. L.; Poorman, M. C.

2012-12-19

A high power ({approx}3 kW) target platform has been developed for the IBA 18/9 cyclotron. New designs for the airlock, collimator and target subsystems have been fabricated and deployed. The primary project goal is reliable commercial production of 18F{sup -} at 150 {mu}A or greater, while secondary goals include improving serviceability and extending service intervals relative to OEM systems. Reliable operation in a production environment has been observed at beam currents up to 140 {mu}A. Challenges include ion source lifetime and localized peaking in the beam intensity distribution.

MEASUREMENT OF THE CROSS-SECTION FOR THE γ γ -> p/line{p} PROCESS AT √ {s} = 183 - 189\\ GeV AT LEP

NASA Astrophysics Data System (ADS)

Barillari, T.

2002-07-01

The OPAL detector at LEP has been used to study the exclusive production of proton antiproton pairs in the collisions of two quasi-real photons using data taken at √ {s} = 183\\ GeV and 189 GeV. The results here presented are for γγ invariant masses, W, in the range 2.15 GeV < W < 3.95 GeV. The cross-section measurements are compared with previous data and with recent analytic calculations based on the quark-diquark model predictions.

Thermochemistry and Kinetics of the Cl+O2 Association Reaction

NASA Technical Reports Server (NTRS)

Nicovich, J. M.; Kreutter, K. D.; Shackelford, C. J.; Wine, P. H.

1997-01-01

Laser flash photolysis of Cl2/O2 mixtures has been employed in conjunction with Cl((sup 2)P(sub 3/2)) detection by time-resolved fluorescence spectroscopy to investigate equilibration kinetics for the reactions Cl + O2 + O is in equilibrium with ClOO + O2 at temperatures of 181-200 K and O2 pressures of 15-40 Torr. The third-order rate coefficient for the association reaction at 186.5 +/- 5.5 K is (8.9 +/- 2.9) x 10(exp -33) cm(exp 6) molecule(exp -2) s(exp -1) and the equilibrium constant (K(p)) at 185.4 K is 18.9 atm(exp -1) (factor of 1.7 uncertainty). A third law analysis of our data leads to a value for the Cl-OO bond dissociation energy of 4.76 +/- 0.49 kcal mol(exp -1).

F-15 Avionics Test Station and Component Specialist Career Ladder. Occupational Survey Report

DTIC Science & Technology

1990-02-01

Or ko m qdl U(. NL ) ULU 0Z M-: 0 C) Z: -3 F M C- OC>mC I - oL D, V) C)L )C- O C) o Or- F ) j CRd jMm i CDd L.L CD C) .0 C) V)= .00 U~00 LUU off0.0...LO C CO UJ LI(4 .00 r" r r"~i ell ko 1 C I" C) 4 -4 C’J C3 C CD V) 𔃾A ~ C) CC F-4 LU< Q-C =D F-( Ln J(I -4C Cr- 1-d C C C C C) C> C C d >- LL EL-C...CONSOLIDATED TOOL KITS (CTK) AND TOOL ROOM CHITS 68 H291 ISOLATE MALFUNCTIONS WITHIN LEAD COMPUTING GYRO (LCG) LRUs 66 F189 INTERPRET SYSTEM DIAGRAMS OR

The Interaction of CuS and Halothiobacillus HT1 Biofilm in Microscale Using Synchrotron Radiation-Based Techniques

PubMed Central

Lin, Huirong; Chen, Guangcun; Zhu, Shenhai; Chen, Yingxu; Chen, Dongliang; Xu, Wei; Yu, Xiaohan; Shi, Jiyan

2013-01-01

In order to investigate the microbe-mineral interaction in the micro scale, spatial distribution and speciation of Cu and S in Halothiobacillus HT1 biofilm formed on a CuS surface was examined using synchrotron-based X-ray techniques. Confocal laser scanning microscope (CLSM) results indicated that Halothiobacillus HT1 biofilm formation gave rise to distinct chemical and redox gradients, leading to diverse niches in the biofilm. Live cells were distributed at the air-biofilm and membrane-biofilm interface. CuS was oxidized by Halothiobacillus HT1 biofilm, and copper penetrated into the biofilm. Sulfide was oxidized to cysteine (77.3%), sulfite (3.8%) and sulfonate (18.9%). Cu-cysteine-like species were involved in the copper homeostasis. These results significantly improve our understanding of the interfacial properties of the biofilm-mineral interface. PMID:23708108

Status of the OPERA experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, A.

2011-11-23

The OPERA experiment in the underground Gran Sasso Laboratory (LNGS) has been designed to perform the first detection of neutrino oscillations in direct appearance mode in the muon to tau neutrino channel. The detector is hybrid, being made of an emulsion/lead target and of electronic detectors. It is placed in the CNGS neutrino beam 733 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out from 2008 and the following years. The analysis of a sample of events corresponding to 1.89x10{sup 19} p.o.t. in the CERN CNGS {nu}{sub {mu}} beam yielded the observation of a firstmore » candidate {nu}{sub {tau}} CC interaction. The topology and kinematics of this candidate event is described in detail. The background sources are explained and the significance of the observation of the first {nu}{sub {tau}} event candidate is assessed.« less

Implant and clinical characteristics for pediatric and congenital heart patients in the national cardiovascular data registry implantable cardioverter defibrillator registry.

PubMed

Jordan, Christopher P; Freedenberg, Vicki; Wang, Yongfei; Curtis, Jeptha P; Gleva, Marye J; Berul, Charles I

2014-12-01

In 2010, the National Cardiovascular Data Registry enhanced pediatric, nonatherosclerotic structural heart disease and congenital heart disease (CHD) data collection. This report characterizes CHD and pediatric patients undergoing implantable cardioverter defibrillator implantation. In this article, we report implantable cardioverter defibrillator procedures (April 2010 to December 2012) in the registry for 2 cohorts: (1) all patients with CHD (atrial septal defect, ventricular septal defect, tetralogy of Fallot, Ebstein anomaly, transposition of the great vessels, and common ventricle) and (2) patients <21 years. We evaluated indications and characteristics to include transvenous and nontransvenous lead implants, CHD type, and New York Heart Association class. There were 3139 CHD procedures, 1601 for patients <21 years and 126 for CHD <21 years. Implantable cardioverter defibrillator indications for patients with CHD were primary prevention in 1943 (61.9%) and secondary prevention in 1107 (35.2%). Pediatric patients had 935 (58.4%) primary prevention and 588 (36.7%) secondary prevention devices. Primary prevention had higher New York Heart Association class. Nontransvenous age (35.9 ± 23.2 versus 40.1 ± 24.6 years; P=0.05) and nontransvenous height (167.1 ± 18.9 cm; range, 53-193 cm versus 170.4 ± 13.1 cm; range, 61-203 cm; P<0.01) were lower than for transvenous patients. CHD and pediatrics had similar rates of transvenous (97%) and nontransvenous (3%) leads and did not differ from the overall registry. Transposition of the great vessels and common ventricle had higher rates of nontransvenous leads. Primary prevention exceeds secondary prevention for CHD and pediatrics. Nontransvenous lead patients were younger, with higher rates of transposition of the great vessels and common ventricle patients compared with transvenous lead patients. © 2014 American Heart Association, Inc.

Emergence and Kinetics of Simian Immunodeficiency Virus-Specific CD8+ T Cells in the Intestines of Macaques during Primary Infection

PubMed Central

Veazey, Ronald S.; Gauduin, Marie-Claire; Mansfield, Keith G.; Tham, Irene C.; Altman, John D.; Lifson, Jeffrey D.; Lackner, Andrew A.; Johnson, R. Paul

2001-01-01

In this report, three Mamu-A*01+ rhesus macaques were examined to compare the emergence of simian immunodeficiency virus (SIV)-specific CD8+ T cells in the intestines and blood in early SIV infection using a major histocompatibility complex class I tetramer complexed with the Gag181–189 peptide. Fourteen days after intravenous inoculation with SIVmac251, large numbers of SIV Gag181–189-specific CD8+ T cells were detected in the intestinal mucosa (3.1 to 11.5% of CD3+ CD8+ lymphocytes) as well as in the blood (3.1 to 13.4%) of all three macaques. By 21 days postinoculation, levels of tetramer-binding cells had dropped in both the intestines and blood. At day 63, however, levels of SIV Gag181–189-specific CD8+ T cells in the intestines had rebounded in all three macaques to levels that were higher (8.6 to 18.7%) than those at day 21. In contrast, percentages of tetramer-binding cells in the peripheral blood remained comparatively stable (2.5 to 4.5%) at this time point. In summary, SIV Gag181–189-specific CD8+ T cells appeared in both the intestinal mucosa and peripheral blood at a comparable rate and magnitude in primary SIV infection. Given that the intestine is a major site of early viral replication as well as the site where most of the total body lymphocyte pool resides, these data indicate that it is also an early and important site of development of antiviral immune responses. PMID:11581423

HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.

PubMed

Cantonwine, David; Hu, Howard; Téllez-Rojo, Martha Maria; Sánchez, Brisa N; Lamadrid-Figueroa, Héctor; Ettinger, Adrienne S; Mercado-García, Adriana; Hernández-Avila, Mauricio; Wright, Robert O

2010-07-26

Neonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight. We investigated the role of HFE C282Y, HFE H63 D, and transferrin (TF) P570 S gene variants in modifying the association of lead and infant birthweight in a cohort of Mexican mother-infant pairs. Subjects were initially recruited between 1994-1995 from three maternity hospitals in Mexico City and 411 infants/565 mothers had archived blood available for genotyping. Multiple linear regression models, stratified by either maternal/infant HFE or TF genotype and then combined with interaction terms, were constructed examining the association of lead and birthweight after controlling for covariates. 3.1%, 16.8% and 17.5% of infants (N=390) and 1.9%, 14.5% and 18.9% of mothers (N=533) carried the HFE C282Y, HFE H63D, and TF P570 S variants, respectively. The presence of infant HFE H63 D variants predicted 110.3 g (95% CI -216.1, -4.6) decreases in birthweight while maternal HFE H63 D variants predicted reductions of 52.0 g (95% CI -147.3 to 43.2). Interaction models suggest that both maternal and infant HFE H63 D genotype may modify tibia lead's effect on infant birthweight in opposing ways. In our interaction models, maternal HFE H63 D variant carriers had a negative association between tibia lead and birthweight. These results suggest that the HFE H63 D genotype modifies lead's effects on infant birthweight in a complex fashion that may reflect maternal-fetal interactions with respect to the metabolism and transport of metals.

The toxicity of different lead salts to Enchytraeus crypticus in relation to bioavailability in soil.

PubMed

Zhang, Lulu; Van Gestel, Cornelis A M

2017-08-01

The present study aimed to assess the bioavailability and toxicity of lead nitrate and lead chloride to Enchytraeus crypticus in a natural standard soil. Worms were exposed to Pb-spiked soil for 21 d, and survival and reproduction were related to total, 0.01 M CaCl 2 -extractable, and porewater Pb concentrations in the soil and internal concentrations in the surviving animals. The Pb availability for Pb(NO 3 ) 2 and PbCl 2 was similar, as confirmed by Langmuir and Freundlich isotherms. The Pb concentrations in surviving worms increased with increasing Pb concentrations in the soil and did not differ for the 2 Pb salts. Lead was toxic to E. crypticus at median lethal concentrations (LC50s) of 543 and 779 mg Pb/kg dry soil and median effect concentrations (EC50s) of 189 and 134 mg Pb/kg dry soil, for Pb(NO 3 ) 2 and PbCl 2 , respectively. Mortality of E. crypticus was related to internal Pb concentrations in the worms rather than to total or available Pb concentrations in the soil, whereas reproduction toxicity was better explained from Pb concentrations in 0.01 M CaCl 2 extracts or porewater of the test soil than from total Pb concentrations in the soil or Pb concentrations in the worms. Overall, the bioavailability and toxicity of Pb(NO 3 ) 2 and PbCl 2 to E. crypticus in LUFA 2.2 soil did not differ. Environ Toxicol Chem 2017;36:2083-2091. © 2017 SETAC. © 2017 SETAC.

Crew appliance computer program manual, volume 1

NASA Technical Reports Server (NTRS)

Russell, D. J.

1975-01-01

Trade studies of numerous appliance concepts for advanced spacecraft galley, personal hygiene, housekeeping, and other areas were made to determine which best satisfy the space shuttle orbiter and modular space station mission requirements. Analytical models of selected appliance concepts not currently included in the G-189A Generalized Environmental/Thermal Control and Life Support Systems (ETCLSS) Computer Program subroutine library were developed. The new appliance subroutines are given along with complete analytical model descriptions, solution methods, user's input instructions, and validation run results. The appliance components modeled were integrated with G-189A ETCLSS models for shuttle orbiter and modular space station, and results from computer runs of these systems are presented.

Superdeformed shapes and configurations in thallium nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reviol, W.; Mueller, W.F.; Riedinger, L.L.

1997-09-01

Superdeformation studies in {sup 189,191,192}Tl at Gammasphere are discussed. New results on {sup 191}Tl are the observation of interband transitions between the signature partner E2 bands and the measurement of an average quadrupole moment (Q{sub 0} = 18 {+-} 1 eb) for these superdeformed structures. These data enable them to derive absolute M1 strengths and confirm that the 81st proton occupies the [642]5/2 orbital. Tentative data for one superdeformed sequence in {sup 189}Tl are consistent with the prediction of a decrease in quadrupole deformation for the lightest nuclei at the limit of this island of superdeformation.

Sulfated polysaccharide from the leaves of Artemisia Princeps activates heparin cofactor II independently of the Lys173 and Arg189 residues of heparin cofactor II.

PubMed

Hayashi, T; Hayakawa, Y; Hayashi, T; Sasaki, H; Sakuragawa, N

1997-07-01

A sulfated polysaccharide (AFE-HCD) purified from the leaves of Artemisia princeps Pamp selectively accelerated the rate of thrombin inhibition by heparin cofactor II (HCII). By using plasma derived HCII and bacterial expressed recombinant HCII molecules, the interaction between each HCII molecule and AFE-HCD was analyzed. AFE-HCD accelerated thrombin inhibition by plasma derived HCII or bacterial expressed wild type HCII to the same extent (IC50: 0.056 micrograms/ml for plasma derived HCII and 0.066 micrograms/ml for recombinant HCII under the experimental condition). The recombinant HCII (rHCII) molecule with Lys173-->Leu or Arg189-->His substitution, which is defective in interactions with heparin and dermatan sulfate, respectively, is activated by AFE-HCD to inhibit thrombin in a manner similar to wild type rHCII. These results suggested that activation of HCII was independent of its Lys173 or Arg189 residue. Although AFE-HCD is a selective activator of HCII like dermatan sulfate, the amino acid residue required for the activation of HCII was distinct form that of dermatan sulfate as well as heparin.

Major thermal springs of Utah

USGS Publications Warehouse

Mundorff, J.C.

1970-01-01

As part of a study of the springs of Utah, reconnaissance data were obtained on the thermal, chemical, and geologic characteristics of the major thermal springs or Utah. Only three of the springs have temperatures near the boiling point of water; the maximum recorded temperatures of these springs range from 185° to 189° F. All three springs are in or near areas of late Tertiary or Quaternary volcanism.Temperatures of the thermal springs studied ranged from 68° to 189° F. Nearly all thermal springs in Utah are in or near fault zones. Very few of these springs issue from volcanic rocks, but several springs are close to areas of late Tertiary or Quaternary volcanic rocks.

Mobilization and Defense Management Technical Reports Series. Mobilization Studies Program Report. Selective Service Boards. Will They Be Ready?

DTIC Science & Technology

1983-05-01

Element (W)I (W2)2 Factors Male 87.5 81.1 +6.4 Sex Female 12.5 18.9 -6.4 Married to.@ 81.7 +18.3 Marital Status Single 6.0 18.3 -18.3 ( 30 0.8 6.9 -6.9...March 1982. i0 ~16l Table 2.1 Demographic Data on Local Boards. (33:12) Number of Local Boards 2,113 Board Positions 16,560 Sex of Board membe s...Effort and ~Reward (n - 175) Actual Expected Effort Response Response Reward Element (%)I (,) 2 Factor3 Male 83.9 81.1 +2.8 Sex Female 16.1 18.9 -2.8

Initial clinical experience with cardiac resynchronization therapy utilizing a magnetic navigation system.

PubMed

Gallagher, Peter; Martin, Laura; Angel, Lori; Tomassoni, Gery

2007-02-01

The placement of left ventricular (LV) leads during cardiac resynchronization therapy (CRT) involves many technical difficulties. These difficulties increase procedural times and decrease procedural success rates. A total of 50 patients with severe cardiomyopathy (mean LV ejection fraction was 21 +/- 6%) and a wide QRS underwent CRT implantation. Magnetic navigation (Stereotaxis, Inc.) was used to position a magnet-tipped 0.014'' guidewire (Cronus guidewire) within the coronary sinus (CS) vasculature. LV leads were placed in a lateral CS branch, either using a standard CS delivery sheath or using a "bare-wire" approach without a CS delivery sheath. The mean total procedure time was 98.1 +/- 29.1 minutes with a mean fluoroscopy time of 22.7 +/- 15.1 minutes. The mean LV lead positioning time was 10.4 +/- 7.6 minutes. The use of a delivery sheath was associated with longer procedure times 98 +/- 32 minutes vs 80 +/- 18 minutes (P = 0.029), fluoroscopy times 23 +/- 15 minutes vs 13 +/- 4 minutes (P = 0.0007) and LV lead positioning times 10 +/- 6 minutes vs 4 +/- 2 minutes (P = 0.015) when compared to a "bare-wire" approach. When compared with 52 nonmagnetic-assisted control CRT cases, magnetic navigation reduced total LV lead positioning times (10.4 +/- 7.6 minutes vs 18.6 +/- 18.9 minutes; P = 0.005). If more than one CS branch vessel was tested, magnetic navigation was associated with significantly shorter times for LV lead placement (16.2 +/- 7.7 minutes vs 36.4 +/- 23.4 minutes; P = 0.004). Magnetic navigation is a safe, feasible, and efficient tool for lateral LV lead placement during CRT. Magnetic navigation during CRT allows for control of the tip direction of the Cronus 0.014'' guidewire using either a standard CS delivery sheath or "bare-wire" approach. Although there are some important limitations to the 0.014'' Cronus magnetic navigation can decrease LV lead placement times compared with nonmagnetic-assisted control CRT cases, particularly if multiple CS branches are to be tested.

Abrasive-assisted Nickel Electroforming Process with Moving Cathode

NASA Astrophysics Data System (ADS)

REN, Jianhua; ZHU, Zengwei; XIA, Chunqiu; QU, Ningsong; ZHU, Di

2017-03-01

In traditional electroforming process for revolving parts with complex profiles, the drawbacks on surface of deposits, such as pinholes and nodules, will lead to varying physical and mechanical properties on different parts of electroformed components. To solve the problem, compositely moving cathode is employed in abrasive-assisted electroforming of revolving parts with complicated profiles. The cathode translates and rotates simultaneously to achieve uniform friction effect on deposits without drawbacks. The influences of current density and translation speed on the microstructure and properties of the electroformed nickel layers are investigated. It is found that abrasive-assisted electroforming with compound cathode motion can effectively remove the pinholes and nodules, positively affect the crystal nucleation, and refine the grains of layer. The increase of current density will lead to coarse microstructure and lower micro hardness, from 325 HV down to 189 HV. While, faster translational linear speed produces better surface quality and higher micro hardness, from 236 HV up to 283 HV. The weld-ability of the electroformed layers are also studied through the metallurgical analysis of welded joints between nickel layer and 304 stainless steel. The electrodeposited nickel layer shows fine performance in welding. The novel compound motion of cathode promotes the mechanical properties and refines the microstructure of deposited layer.

Trace metals health risk appraisal in fish species of Arabian Sea.

PubMed

Yasmeen, Kousar; Mirza, Muhammad Aslam; Khan, Namra A; Kausar, Nazish; Rehman, Atta-Ur; Hanif, Muddasir

2016-01-01

Fish is a vital food for humans and many animals. We report an environmental monitoring study to assess the trace metals in fish species caught from Arabian Sea and commercially available in the coastal city Karachi, Pakistan. Heavy metals such as copper, iron, lead and cadmium were determined in the skin, fillet and heart of the fish species Pampus argenteus, Epinephelus chlorostigma, Rachycentron canadum, Scomberomorus commerson, Johnius belangerii, Labeo rohita, Lutjanus argentimaculatus, Trachinotus blochii, Pomadsys olivaceum and Acanthopagrus berda by the atomic absorption spectrophotometer. The concentration (mg kg(-1), dry weight) range was: Cd (0.00-0.041), Cu (0.006-0.189), Fe (0.413-4.952) and Pb (0.00-0.569). Cadmium, copper and iron levels were below the tolerable limits whereas concentration of lead in the skins of S. commerson, E. chlorostigma, J. belangerii, A. berda; L. argentimaculatus, fillets of J. belangerii, E. chlorostigma and in the heart of J. belangerii exceeded the recommended limits. Therefore fish skin should be discouraged as food for humans or animals. The results indicate that a number of fish species have higher concentration of heavy metals dangerous for human health. Since the fish P. olivaceum (Dhotar) has the lowest level of trace metals therefore we recommend it for breeding and human consumption.

The budget impact of oral nutritional supplements for disease related malnutrition in elderly in the community setting.

PubMed

Freijer, Karen; Nuijten, Mark J C; Schols, Jos M G A

2012-01-01

A health economic analysis was performed to assess the economic impact on the national health care budget of using oral nutritional supplements (ONS), being a food for special medical purposes also known as medical nutrition, for the treatment of disease related malnutrition (DRM) in the community in the Netherlands. An economic model was developed to calculate the budget impact of using ONS in community dwelling elderly (>5 years) with DRM in the Netherlands. The model reflects the costs of DRM and the cost reductions resulting from improvement in DRM due to treatment with ONS. Using ONS for the treatment of DRM in community dwelling elderly, leads to a total annual cost savings of € 13 million (18.9% savings), when all eligible patients are treated. The additional costs of ONS (€ 57 million) are more than balanced by a reduction of other health care costs, e.g., re-/hospitalization (€ 70 million). Sensitivity analyses were performed on all parameters, including duration of treatment with ONS and the prevalence of DRM. This budget impact analysis shows that the use of ONS for treatment of DRM in elderly patients in the community may lead to cost savings in the Netherlands.

Legionella pollution in cooling tower water of air-conditioning systems in Shanghai, China.

PubMed

Lin, H; Xu, B; Chen, Y; Wang, W

2009-02-01

To determine Legionella pollution prevalence, describe the amount of Legionellae with respect to temperature in Shanghai cooling tower water (CTWs) in various types of public sites. Six urban districts were selected as the study fields, adopting multiple-phase sampling methods. Routine culture was used to identify Legionellae. Of the samples, 58.9% (189/321) were observed to be positive, 19.9% were isolated over 100 CFU ml(-1). Legionella pneumophila serogroup 1 was the most frequently isolated species (155/189, 82.0%), followed by Leg. micdadei that was at the second place (44/189, 23.3%). The mean CFU ml(-1) of Legionellae in CTWs reached its peak from July to September. Over all 15.4% of the samples exceeding 100 CFU ml(-1) were observed in a hospital setting. The prevalence of Legionella pollution in CTWs, especially in CTWs of subway stations and hospitals, is worrying, and the positive rate and CFU ml(-1) of Legionellae in CTWs have a close relationship with air temperature. The study demonstrates pollution prevalence rates in different types of sites and various seasons, and provides a proportion of different serogroups of Legionellae. It illuminates an urgent need for dealing with the potential risk of legionellosis in Shanghai, through improved control and prevention strategies.

Generation of gas-phase sodiated arenes such as [(Na3(C6H4)+] from benzene dicarboxylate salts.

PubMed

Attygalle, Athula B; Chan, Chang-Ching; Axe, Frank U; Bolgar, Mark

2010-01-01

Upon collision-induced activation, gaseous sodium adducts generated by electrospray ionization of disodium salts of 1,2- 1,3-, and 1,4-benzene dicarboxylic acids (m/z 233) undergo an unprecedented expulsion of CO(2) by a rearrangement process to produce an ion of m/z 189 in which all three sodium atoms are retained. When isolated in a collision cell of a tandem-in-space mass spectrometer, and subjected to collision-induced dissociation (CID), only the m/z 189 ions derived from the meta and para isomers underwent a further CO(2) loss to produce a peak at m/z 145 for a sodiated arene of formula (Na(3)C(6)H(4))(+). This previously unreported m/z 145 ion, which is useful to differentiate meta and para benzene dicarboxylates from their ortho isomer, is in fact the sodium adduct of phenelenedisodium. Moreover, the m/z 189 ion from all three isomers readily expelled a sodium radical to produce a peak at m/z 166 for a radical cation [(*C(6)H(4)CO(2)Na(2))(+)], which then eliminated CO(2) to produce a peak at m/z 122 for the distonic cation (*C(6)H(4)Na(2))(+). Copyright 2009 John Wiley & Sons, Ltd.

Induction of cell death by tospoviral protein NSs and the motif critical for cell death does not control RNA silencing suppression activity.

PubMed

Singh, Ajeet; Permar, Vipin; Jain, R K; Goswami, Suneha; Kumar, Ranjeet Ranjan; Canto, Tomas; Palukaitis, Peter; Praveen, Shelly

2017-08-01

Groundnut bud necrosis virus induces necrotic symptoms in different hosts. Previous studies showed reactive oxygen species-mediated programmed cell death (PCD) resulted in necrotic symptoms. Transgenic expression of viral protein NSs mimics viral symptoms. Here, we showed a role for NSs in influencing oxidative burst in the cell, by analyzing H 2 O 2 accumulation, activities of antioxidant enzymes and expression levels of vacuolar processing enzymes, H 2 O 2 -responsive microRNA 319a.2 plus its possible target metacaspase-8. The role of NSs in PCD, was shown using two NSs mutants: one in the Trp/GH3 motif (a homologue of pro-apototic domain) (NSs S189R ) and the other in a non-Trp/GH3 motif (NSs L172R ). Tobacco rattle virus (TRV) expressing NSs S189R enhanced the PCD response, but not TRV-NSs L172R , while RNA silencing suppression activity was lost in TRV-NSs L172R , but not in TRV-NSs S189R . Therefore, we propose dual roles of NSs in RNA silencing suppression and induction of cell death, controlled by different motifs. Copyright © 2017 Elsevier Inc. All rights reserved.

Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children.

PubMed

Kim, Stephani; Arora, Monica; Fernandez, Cristina; Landero, Julio; Caruso, Joseph; Chen, Aimin

2013-10-01

There is limited research examining the relationship between lead (Pb) exposure and medically diagnosed attention deficit hyperactivity disorder (ADHD) in children. The role of mercury (Hg) and cadmium (Cd) exposures in ADHD development is even less clear. To examine the relationship between Pb, Hg, and Cd and ADHD in children living inside and outside a Lead Investigation Area (LIA) of a former lead refinery in Omaha, NE. We carried out a case-control study with 71 currently medically diagnosed ADHD cases and 58 controls from a psychiatric clinic and a pediatric clinic inside and outside of the LIA. The participants were matched on age group (5-8, 9-12 years), sex, race (African American or Caucasians and others), and location (inside or outside LIA). We measured whole blood Pb, total Hg, and Cd using inductively coupled plasma mass spectrometry. Inside the LIA, the 27 cases had blood Pb geometric mean (GM) 1.89 µg/dL and the 41 controls had 1.51 µg/dL. Outside the LIA, the 44 cases had blood Pb GM 1.02 µg/dL while the 17 controls had 0.97 µg/dL. After adjustment for matching variables and maternal smoking, socioeconomic status, and environmental tobacco exposure, each natural log unit blood Pb had an odds ratio of 2.52 with 95% confidence interval of 1.07-5.92. Stratification by the LIA indicated similar point estimate but wider CIs. No associations were observed for Hg or Cd. Postnatal Pb exposure may be associated with higher risk of clinical ADHD, but not the postnatal exposure to Hg or Cd. © 2013 Published by Elsevier Inc.

Lead, Mercury, and Cadmium Exposure and Attention Deficit Hyperactivity Disorder in Children

PubMed Central

Kim, Stephani; Arora, Monica; Fernandez, Cristina; Caruso, Joseph; Landero, Julio; Chen, Aimin

2013-01-01

Background There is limited research examining the relationship between lead (Pb) exposure and medically diagnosed Attention Deficit Hyperactivity Disorder (ADHD) in children. The role of mercury (Hg) and cadmium (Cd) exposures in ADHD development is even less clear. Objectives To examine the relationship between Pb, Hg, and Cd and ADHD in children living inside and outside a Lead Investigation Area (LIA) of a former lead refinery in Omaha, NE. Methods We carried out a case-control study with 71 currently medically diagnosed ADHD cases and 58 controls from a psychiatric clinic and a pediatric clinic inside and outside of the LIA. The participants were matched on age group (5–8, 9–12 years), sex, race (African American or Caucasians and Others), and location (inside or outside LIA). We measured whole blood Pb, total Hg, and Cd using Inductively Coupled Plasma Mass Spectrometry. Results Inside the LIA, the 27 cases had blood Pb Geometric Mean (GM) 1.89 µg/dL and the 41 controls had 1.51 µg/dL. Outside the LIA, the 44 cases had blood Pb GM 1.02 µg/dL while the 17 controls had 0.97 µg/dL. After adjustment for matching variables and maternal smoking, socioeconomic status, and environmental tobacco exposure, each natural log unit blood Pb had an odds ratio of 2.52 with 95% confidence interval of 1.07–5.92. Stratification by the LIA indicated similar point estimate but wider CIs. No associations were observed for Hg or Cd. Conclusions Postnatal Pb exposure may be associated with higher risk of clinical ADHD, but not the postnatal exposure to Hg or Cd. PMID:24034783

The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries.

PubMed

Costa, A C C; Coelho, E B; Lanchote, V L; Correia, B V; Abumansur, J T; Lauretti, G R; de Moraes, N V

2017-08-01

Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA). Rocuronium pharmacokinetic parameters were estimated by non-compartmental analysis. None of the patients had heterozygous or homozygous variant of 404A>T, 382A>T, 502C>T, 833delA, 830C>A, 41A>G, and -715T>C. A linkage disequilibrium was found between -1105G>A and -1032G>A genotypes. Patients genotyped as -A or AA (n = 17) for SLCO1A2 -189_-188InsA showed reduced total clearance of ROC compared to patients genotyped as -/- (n = 13) (151.6 vs 207.1 mL/min, p ≤ 0.05). The pharmacokinetics parameters of ROC were not significantly different between other SLCO1A2 genotypes. SLCO1A2 -189_-188InsA polymorphism is related to the reduced clearance of rocuronium in patients submitted to elective surgeries under general anesthesia. NCT 02399397 ( ClinicalTrials.gov ).

Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis.

PubMed

Santos, Ana M; Peña, Paola; Avila, Mabel; Briceño, Ignacio; Jaramillo, Carlos; Vargas-Alarcon, Gilberto; Rueda, Juan C; Saldarriaga, Eugenia-Lucia; Angarita, Jose-Ignacio; Martinez-Rodriguez, Nancy; Londono, John

2017-04-01

There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.

Incidence and Outcomes of Inferior Vena Cava Filter Thrombus during Catheter-directed Thrombolysis for Proximal Deep Venous Thrombosis.

PubMed

Jiang, Jianguang; Tu, Jianfei; Jia, Zhongzhi; Chen, Jiezhong; Cao, Haitao; Meng, Qingli; Fuller, Tyler A; Tian, Feng

2017-01-01

The aim of the study was to retrospectively evaluate the incidence and outcomes of inferior vena cava (IVC) filter thrombus during catheter-directed thrombolysis (CDT) for acute proximal deep venous thrombosis (DVT). From October 2006 to June 2015, patients diagnosed with acute proximal DVT and received CDT after a retrievable IVC filter was placed were included. The incidence, treatment, and outcomes of IVC filter thrombus during CDT were recorded and analyzed. A total of 189 patients (91 women, 98 men; mean age, 57.6 ± 9.8 years; range, 24-85 years) were included in this study. Among the 189 cases, the DVTs involved popliteal iliofemoral veins in 54 patients, iliofemoral veins in 113 patients, and iliac veins in 22 patients, of which 18 patients had thrombus extended into the IVC. Of the 189 patients, a total of 8 (4.2%, 8 of 189) patients were identified with IVC filter thrombus during CDT. The IVC filter thrombus was detected on a median of 2 days (range, 2-4 days) of CDT therapy, including small-size (n = 6) and large-size (n = 2) filter thrombus. Of the 8 patients, CDTs were performed with a mean 7.6 ± 1.1 days (range, 6-11 days) after the presence of symptoms for the treatment of proximal DVT, and all the IVC filter thrombi were lysed during CDT for the proximal DVT. All the IVC filters were removed successfully with a mean of 12.8 ± 0.93 days from placement. There were no procedure- or thrombolysis-related major complications, and no symptomatic pulmonary embolism breakthrough was seen in any of the patients after the filter placement. IVC filter thrombus during CDT for the acute proximal DVT is uncommon, and all of them did not need any additional treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kB-dependent signaling

PubMed Central

Castri, Paola; Lee, Yang-ja; Ponzio, Todd; Maric, Dragan; Spatz, Maria; Bembry, Joliet; Hallenbeck, John

2014-01-01

Poly(ADP-ribose) polymerase-1 (PARP-1) and its cleavage products regulate cell viability and NF-kB activity when expressed in neurons. PARP-1 cleavage generates a 24kDa (PARP-124) and an 89kDa fragment (PARP-189). Compared to WT (PARP-1WT), the expression of an uncleavable PARP-1 (PARP-1UNCL) or of PARP-124 conferred protection from oxygen/glucose deprivation (OGD) or OGD/restoration of oxygen and glucose (ROG) damage in vitro, whereas expression of PARP-189 was cytotoxic. Viability experiments were performed in SH-SY5Y, a human neuroblastoma cell line, as well as in rat primary cortical neurons. Following OGD, the higher viability in the presence of PARP-1UNCL or PARP-124 was not accompanied with decreased formation of poly(ADP-riboses) or higher NAD levels. PARP-1 is a known cofactor for NF-kB, hence we investigated whether PARP-1 cleavage influences the inflammatory response. All PARP-1 constructs mimicked PARP-1WT in regards to induction of NF-kB translocation into the nucleus and its increased activation during ischemic challenge. However, expression of PARP-189 construct induced significantly higher NF-kB activity than PARP-1WT; and the same was true for NF-kB-dependent iNOS promoter binding activity. At a protein level, PARP-1UNCL and PARP-124 decreased iNOS (and lower levels of iNOS transcript) and COX-2, and increased Bcl-xL. The increased levels of NF-kB and iNOS transcriptional activities, seen with cytotoxic PARP-189, were accompanied by higher protein expression of COX-2 and iNOS (and higher levels of iNOS transcript) and lower protein expression of Bcl-xL. Taken together, these findings suggest that PARP-1 cleavage products may regulate cellular viability and inflammatory responses in opposing ways during in vitro models of “ischemia”. PMID:24333653

Prevalence of hepatitis B and hepatitis C virus co-infection in India: A systematic review and meta-analysis.

PubMed

Desikan, Prabha; Khan, Zeba

2017-01-01

Hepatitis B virus (HBV) and hepatitis C virus (HCV) have several important similarities including worldwide distribution, hepato-tropism, similar modes of transmission and the ability to induce chronic infection that may lead to liver cirrhosis and hepatocellular carcinoma. Since both viruses are individually known to cause the pathologies mentioned above, co-infection with both HBV and HCV would be expected to be linked with higher morbidity as well as mortality and impact healthcare resource utilisation. Precise estimate of the prevalence of HBV/HCV co-infection would be needed to formulate policy decisions and plan communal health interventions. This systematic review and meta-analysis, therefore, aims to understand the prevalence of HBV and HCV co-infection in India based on the available literature. Following PRISMA guidelines, primary studies reporting the prevalence of HBV/HCV co-infection in India were retrieved through searches conducted in PubMed, Google SCHOLAR, Medline, Cochrane Library, WHO reports, Indian and International journals online. All online searches were conducted between December 2016 and February 2017. Meta-analysis was carried out using StatsDirect statistical software. Thirty studies published between 2000 and 2016 conducted across six regions of India were included in this review. The pooled HBV/HCV co-infection prevalence rate across the thirty studies was 1.89% (95% confidence intervals [CI] = 1.2%-2.4%). A high heterogeneity was observed between prevalence estimates. The HBV/HCV co-infection prevalence in different subgroups varied from 0.02% (95% CI = 0.0019%-0.090%) to 3.2% (95% CI = 1.3%-5.9%). The pooled prevalence of HBV/HCV co-infection in India was found to be 1.89%. This systematic review and meta-analysis revealed high prevalence of HBV/HCV co-infection in chronic liver patients, followed by HIV-positive patients, and then followed by persons who inject drugs and kidney disease patients.

Admission hyperglycemia predicts poorer short- and long-term outcomes after primary percutaneous coronary intervention for ST-elevation myocardial infarction.

PubMed

Chen, Pei-Chi; Chua, Su-Kiat; Hung, Huei-Fong; Huang, Chung-Yen; Lin, Chiu-Mei; Lai, Shih-Ming; Chen, Yen-Ling; Cheng, Jun-Jack; Chiu, Chiung-Zuan; Lee, Shih-Huang; Lo, Huey-Ming; Shyu, Kou-Gi

2014-02-12

Admission hyperglycemia is associated with poor outcome in patients with myocardial infarction. The present study evaluated the relationship between admission glucose level and other clinical variables in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The 959 consecutive STEMI patients undergoing primary PCI were divided into five groups based on admission glucose levels of <100, 100-139, 140-189, 190-249 and ≥250 mg/dL. Their short- and long-term outcomes were compared. Higher admission glucose levels were associated with significantly higher in-hospital morbidity and mortality, the overall mortality rate at follow up, and the incidence of reinfarction or heart failure requiring admission or leading to mortality at follow up. The odds ratios (95% confidence interval) for in-hospital morbidity, in-hospital mortality, mortality at follow up and re-infarction or heart failure or mortality at follow up of patients with admission glucose levels ≥190 mg/dL, compared with those with admission glucose levels <190 mg/dL, were 2.12 (1.3-3.4, P = 0.001), 2.74 (1.4-5.5, P = 0.004), 2.52 (1.2-5.1, P = 0.01) and 1.70 (1.03-2.8, P = 0.04), respectively. Previously non-diabetic patients with admission glucose levels ≥250 mg/dL had significantly higher in-hospital morbidity or mortality (44 vs 70%, P = 0.03). Known diabetic patients had higher rates of reinfarction, heart failure or mortality at follow up in the 100-139 mg/dL (8 vs 27%, P = 0.04) and 140-189 mg/dL (11 vs 26%, P = 0.02) groups. Admission hyperglycemia, especially at glucose levels ≥190 mg/dL, is a predictor of poor prognosis in STEMI patients undergoing primary PCI.

Acute Toxicity Grade 3 and 4 After Irradiation in Children and Adolescents: Results From the IPPARCA Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pixberg, Caroline; Koch, Raphael; Eich, Hans Theodor, E-mail: Hans.Eich@ukmuenster.de

Purpose: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae. Materials and Methods: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Adolescence (RiSK) database in Germany and since 2008 in the registry for radiation therapy toxicity (RADTOX) in Sweden. Data were collected using standardized, published forms. Toxicity classification was based on Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: Asmore » of June 2013, 1500 children have been recruited into the RiSK database and 485 into the RADTOX registry leading to an analysis population of 1359 patients (age range 0-18). A total of 18.9% (n=257) of all investigated patients developed high-grade acute toxicity (grades 3/4). High-grade toxicity of the bone marrow was documented for 63.8% (n=201) of those patients, oral mucositis for 7.6% (n=24), and dermatitis for 7.6% (n=24). Patients with high-grade acute toxicity received concomitant chemotherapy more frequently (56%) than patients with no or lower acute toxicity (31.5%). In multivariate analyses, concomitant chemotherapy, diagnosis of Ewing sarcoma, and total radiation dose showed a statistically noticeable effect (P≤.05) on acute toxicity, whereas age, concomitant chemotherapy, Hodgkin lymphoma, Ewing sarcoma, total radiation dose, and acute toxicity influenced the time until maximal late toxicity. Conclusions: Generally, high-grade acute toxicity after irradiation in children and adolescence occurs in a moderate proportion of patients (18.9%). As anticipated, the probability of acute toxicity appeared to depend on the prescribed dose as well as concomitant chemotherapy. The occurrence of chronic toxicity correlates with the prior acute toxicity grade. Age seems to influence the time until maximal late toxicity but not the development of acute toxicity.« less

Cannabis use amongst patients with inflammatory bowel disease.

PubMed

Lal, Simon; Prasad, Neeraj; Ryan, Manijeh; Tangri, Sabrena; Silverberg, Mark S; Gordon, Allan; Steinhart, Hillary

2011-10-01

Experimental evidence suggests the endogenous cannabinoid system may protect against colonic inflammation, leading to the possibility that activation of this system may have a therapeutic role in inflammatory bowel disease (IBD). Medicinal use of cannabis for chronic pain and other symptoms has been reported in a number of medical conditions. We aimed to evaluate cannabis use in patients with IBD. One hundred patients with ulcerative colitis (UC) and 191 patients with Crohn's disease (CD) attending a tertiary-care outpatient clinic completed a questionnaire regarding current and previous cannabis use, socioeconomic factors, disease history and medication use, including complimentary alternative medicines. Quality of life was assessed using the short-inflammatory bowel disease questionnaire. A comparable proportion of UC and CD patients reported lifetime [48/95 (51%) UC vs. 91/189 (48%) CD] or current [11/95 (12%) UC vs. 30/189 (16%) CD] cannabis use. Of lifetime users, 14/43 (33%) UC and 40/80 (50%) CD patients have used it to relieve IBD-related symptoms, including abdominal pain, diarrhoea and reduced appetite. Patients were more likely to use cannabis for symptom relief if they had a history of abdominal surgery [29/48 (60%) vs. 24/74 (32%); P=0.002], chronic analgesic use [29/41 (71%) vs. 25/81 (31%); P<0.001], complimentary alternative medicine use [36/66 (55%) vs. 18/56 (32%); P=0.01] and a lower short inflammatory bowel disease questionnaire score (45.1±2.1 vs. 50.3±1.5; P=0.03). Patients who had used cannabis [60/139 (43%)] were more likely than nonusers [13/133 (10%); P<0.001 vs. users] to express an interest in participating in a hypothetical therapeutic trial of cannabis for IBD. Cannabis use is common amongst patients with IBD for symptom relief, particularly amongst those with a history of abdominal surgery, chronic abdominal pain and/or a low quality of life index. The therapeutic benefits of cannabinoid derivatives in IBD may warrant further exploration.

The third molar as an age marker in adolescents: new approach to age evaluation.

PubMed

Rozkovcova, Eva; Dostalova, Tatjana; Markova, Marie; Broukal, Zdenek

2012-09-01

Adolescence is a relatively short period between childhood and adulthood. It is very difficult to determine adulthood based on biological indicators. The third molar may be considered a potential age marker for the period between the ages of 16-21. Our study evaluated a set of 1700 panoramic radiographs of individuals aged between 5 and 21 years. Results confirmed the statistically significant difference in the course of third molars development. The mean deviation for individuals with one third molar agenesis is -0.98 years, for individuals with two third molars agenesis -1.89 years, and with three molars agenesis -3.28 years. Thus, the extent of the deviation is directly proportional to the number of unformed third molars. The calculation of age according to the mean of stages of all third molars could lead to the underestimation of age. No intergender differences were found. Age determination using third molars could be used for forensic purposes. © 2012 American Academy of Forensic Sciences.

Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease.

PubMed

Farid Hosseini, Reza; Jabbari Azad, Farahzad; Yousefzadeh, Hadis; Rafatpanah, Houshang; Hafizi, Saeed; Tehrani, Homan; Khani, Masoud

2014-01-01

Chronic obstructive pulmonary disease (COPD) is a third leading cause of death. In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups. We found that concentration of VEGF in blood serum of patients with COPD (189.9±16pg/ml) was significantly higher than the control group (16.4±3.48pg/ml) (p<0.001). While VEGF serum level in emphysematous patients wasn't significantly different with control group (p=0.07). Furthermore VEGF serum level in COPD patients was proportionally increased with severity of disease (p<0.001). Besides all COPD patients, regardless of their smoking status, were experienced significantly higher levels of VEGF than healthy ones (p=0.001; z=4.3). Our results suggest VEGF serum concentration as the sensitive index for severity and activity of COPD and its prognosis.

Causes of sudden death in young female military recruits.

PubMed

Eckart, Robert E; Scoville, Stephanie L; Shry, Eric A; Potter, Robert N; Tedrow, Usha

2006-06-15

This study sought to examine the incidence of sudden death in a large, multiethnic cohort of young women. Approximately 852,300 women entered basic military training from 1977 to 2001. During this period, there were 15 sudden deaths in female recruits (median age 19 years, 73% African-American), occurring at a median of 25 days after arrival for training. Of the sudden deaths, 13 (81%) were due to reasons that may have been cardiac in origin. Presumed arrhythmic sudden death in the setting of a structurally normal heart was seen in 8 recruits (53%), and anomalous coronary origins were found in 2 recruits (13%). The mortality rate was 11.4 deaths per 100,000 recruit-years (95% confidence interval 6.9 to 18.9). The rate was significantly higher for African-American female recruits (risk ratio 10.2, p <0.001). Sudden death with a structurally normal heart was the leading cause of death in female recruits during military training.

Effect of different drying methods on moisture ratio and rehydration of pumpkin slices.

PubMed

Seremet Ceclu, Liliana; Botez, Elisabeta; Nistor, Oana-Viorela; Andronoiu, Doina Georgeta; Mocanu, Gabriel-Danut

2016-03-15

This study was carried to determine the influence of hot air drying process and combined methods on physicochemical properties of pumpkin (Cucurbita moschata) samples. The experiments in hot air chamber were lead at 50, 60 and 70 °C. The combined method consists of a triple combination of the main drying techniques. Thus, in first stage the samples were dried in hot air convection at 60 °C followed by hot air ventilation at 40 °C simultaneous with microwave. The time required to reduce the moisture content to any given level was highly dependent on the drying conditions. So, the highest value of drying time in hot air has been 540 min at 50 °C, while the lowest time has been 189 min in hot air combined by microwave at 40 °C and a power of 315 W. The samples dried by hot air shows a higher rehydration capacity than samples dried by combined method. Copyright © 2015 Elsevier Ltd. All rights reserved.

Copy number variation in subjects with major depressive disorder who attempted suicide.

PubMed

Perlis, Roy H; Ruderfer, Douglas; Hamilton, Steven P; Ernst, Carl

2012-01-01

Suicide is one of the top ten leading causes of death in North America and represents a major public health burden, particularly for people with Major Depressive disorder (MD). Many studies have suggested that suicidal behavior runs in families, however, identification of genomic loci that drive this efffect remain to be identified. Using subjects collected as part of STAR D, we genotyped 189 subjects with MD with history of a suicide attempt and 1073 subjects with Major Depressive disorder that had never attempted suicide. Copy Number Variants (CNVs) were called in Birdsuite and analyzed in PLINK. We found a set of CNVs present in the suicide attempter group that were not present in in the non-attempter group including in SNTG2 and MACROD2 - two brain expressed genes previously linked to psychopathology; however, these results failed to reach genome-wide signifigance. These data suggest potential CNVs to be investigated further in relation to suicide attempts in MD using large sample sizes.

Sedimentation Survey of Lago El Guineo, Puerto Rico, October 2001

USGS Publications Warehouse

Soler-López, Luis R.

2003-01-01

Lago El Guineo has lost about 17.5 percent of its original storage capacity in 70 years because of sediment accumulation. The water volume has been reduced from 2.29 million cubic meters in 1931, to 2.03 million cubic meters in 1986, and to 1.89 million cubic meters in 2001. The average annual storage-capacity loss (equal to the sedimentation rate) of Lago El Guineo was 4,727 cubic meters for the period of 1931 to July 1986 (or 0.21 percent per year), increasing to 5,714 cubic meters for the period of 1931 to October 2001 (or 0.25 percent per year). Discrepancies that could lead to substantial errors in volume calculations in a small reservoir like Lago El Guineo, were found when transferring the field-collected data into the geographic information system data base 1:20,000 U.S. Geological Survey Jayuya, Puerto Rico quadrangle. After verification and validation of field data, the Lago El Guineo shoreline was rectified using digital aerial photographs and differential global positioning data.

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

PubMed Central

Allman, Erik L.; Painter, Heather J.; Samra, Jasmeet; Carrasquilla, Manuela

2016-01-01

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency for identifying inexpensive chemotherapeutic compounds that are effective against Plasmodium falciparum, the parasite species responsible for the greatest number of malaria-related deaths worldwide. To aid in the fight against malaria, a recent extensive screening campaign has generated thousands of lead compounds with low micromolar activity against blood stage parasites. A subset of these leads has been compiled by the Medicines for Malaria Venture (MMV) into a collection of structurally diverse compounds known as the MMV Malaria Box. Currently, little is known regarding the activity of these Malaria Box compounds on parasite metabolism during intraerythrocytic development, and a majority of the targets for these drugs have yet to be defined. Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 of the drug-like compounds from the Malaria Box) using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention and offer a critical blueprint for selecting and advancing lead compounds as next-generation antimalarial drugs. Our results reveal several major classes of metabolic disruption, which allow us to predict the mode of action (MoA) for many of the Malaria Box compounds. We anticipate that future combination therapies will be greatly informed by these results, allowing for the selection of appropriate drug combinations that simultaneously target multiple metabolic pathways, with the aim of eliminating malaria and forestalling the expansion of drug-resistant parasites in the field. PMID:27572391

Of risks and regulations: how leading U.S. nanoscientists form policy stances about nanotechnology

PubMed Central

Scheufele, Dietram A.; Hu, Qian

2009-01-01

Even though there is a high degree of scientific uncertainty about the risks of nanotechnology, many scholars have argued that policy-making cannot be placed on hold until risk assessments are complete (Faunce, Med J Aust 186(4):189–191, 2007; Kuzma, J Nanopart Res 9(1):165–182, 2007; O’Brien and Cummins, Hum Ecol Risk Assess 14(3):568–592, 2008; Powell et al., Environ Manag 42(3):426–443, 2008). In the absence of risk assessment data, decision makers often rely on scientists’ input about risks and regulation to make policy decisions. The research we present here goes beyond the earlier descriptive studies about nanotechnology regulation to explore the heuristics that the leading U.S. nanoscientists use when they make policy decisions about regulating nanotechnology. In particular, we explore the relationship between nanoscientists’ risk and benefit perceptions and their support for nanotech regulation. We conclude that nanoscientists are more supportive of regulating nanotechnology when they perceive higher levels of risks; yet, their perceived benefits about nanotechnology do not significantly impact their support for nanotech regulation. We also find some gender and disciplinary differences among the nanoscientists. Males are less supportive of nanotech regulation than their female peers and materials scientists are more supportive of nanotechnology regulation than scientists in other fields. Lastly, our findings illustrate that the leading U.S. nanoscientists see the areas of surveillance/privacy, human enhancement, medicine, and environment as the nanotech application areas that are most in need of new regulations. PMID:21170136

46 CFR 189.20-15 - Scope of inspection.

Code of Federal Regulations, 2014 CFR

2014-10-01

... appliances, fire detecting and extinguishing equipment, pilot boarding equipment, pollution prevention... accordance with approved plans, and determine that the vessel is in possession of a valid certificate issued...

46 CFR 189.20-15 - Scope of inspection.

Code of Federal Regulations, 2012 CFR

2012-10-01

... appliances, fire detecting and extinguishing equipment, pilot boarding equipment, pollution prevention... accordance with approved plans, and determine that the vessel is in possession of a valid certificate issued...

46 CFR 189.20-15 - Scope of inspection.

Code of Federal Regulations, 2013 CFR

2013-10-01

... appliances, fire detecting and extinguishing equipment, pilot boarding equipment, pollution prevention... accordance with approved plans, and determine that the vessel is in possession of a valid certificate issued...

46 CFR 189.20-15 - Scope of inspection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... appliances, fire detecting and extinguishing equipment, pilot boarding equipment, pollution prevention... accordance with approved plans, and determine that the vessel is in possession of a valid certificate issued...

46 CFR 189.20-15 - Scope of inspection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... appliances, fire detecting and extinguishing equipment, pilot boarding equipment, pollution prevention... accordance with approved plans, and determine that the vessel is in possession of a valid certificate issued...

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2014 CFR

2014-04-01

... constituent of the sassafras plant. Oil of sassafras is about 80 percent safrole. Isosafrole and dihydrosafrole are derivatives of safrole, and have been used as flavoring compounds. (b) Food containing any...

Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.

PubMed

Pozzi, Nicola; Zerbetto, Mirco; Acquasaliente, Laura; Tescari, Simone; Frezzato, Diego; Polimeno, Antonino; Gohara, David W; Di Cera, Enrico; De Filippis, Vincenzo

2016-07-19

Thrombin exists as an ensemble of active (E) and inactive (E*) conformations that differ in their accessibility to the active site. Here we show that redistribution of the E*-E equilibrium can be achieved by perturbing the electrostatic properties of the enzyme. Removal of the negative charge of the catalytic Asp102 or Asp189 in the primary specificity site destabilizes the E form and causes a shift in the 215-217 segment that compromises substrate entrance. Solution studies and existing structures of D102N document stabilization of the E* form. A new high-resolution structure of D189A also reveals the mutant in the collapsed E* form. These findings establish a new paradigm for the control of the E*-E equilibrium in the trypsin fold.

Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.

PubMed

Hameed, Abdul; Zehra, Syeda T; Shah, Syed J A; Khan, Khalid M; Alharthy, Rima D; Furtmann, Norbert; Bajorath, Jürgen; Tahir, Muhammad N; Iqbal, Jamshed

2015-11-01

Cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), have a role in cholinergic deficit which evidently leads to Alzheimer's disease (AD). Inhibition of cholinesterases with small molecules is an attractive strategy in AD therapy. This study demonstrates synthesis of pyrido[2,3-b]pyrazines (6a-6q) series, their inhibitory activities against both cholinesterases, AChE and BChE, and molecular docking studies. The bioactivities data of pyrido[2,3-b]pyrazines showed 3-(3'-nitrophenyl)pyrido[2,3-b]pyrazine 6n a potent dual inhibitor among the series against both AChE and BChE with IC50 values of 0.466 ± 0.121 and 1.89 ± 0.05 μm, respectively. The analogues 3-(3'-methylphenyl)pyrido[2,3-b]pyrazine 6c and 3-(3'-fluorophenyl)pyrido[2,3-b]pyrazine 6f were found to be selective inhibition for BChE with IC50 values of 0.583 ± 0.052 μm and AChE with IC50 value of 0.899 ± 0.10 μm, respectively. Molecular docking studies of the active compounds suggested the putative binding modes with cholinesterases. The potent compounds among the series could potentially serves as good leads for the development of new cholinesterase inhibitors. © 2015 John Wiley & Sons A/S.

Fatal occupational injuries in the North Carolina construction industry, 1978-1994.

PubMed

Jackson, Seronda A; Loomis, Dana

2002-01-01

Occupational injury is a major public health problem and the cause of high rates of fatalities. The construction industry is one of the leading industries for on-the-job fatalities. The North Carolina Medical Examiner's system was used to identify all fatal unintentional injuries that occurred on the job in the state's construction industry between 1978 and 1994. The populations at risk were estimated from the 1980 and 1990 U.S. censuses. There were 525 identified deaths. All except two decedents were male, and the majority were Caucasian (79.2%). The mean age of decedents was 39 years. Death rates were higher among older workers. The crude fatality rate for the overall study period was 15.4 per 100,000 worker-years, with higher rates found among African-Americans (22.9) than among Caucasians (14.5). Occupations within the industry with the highest rates were laborers (49.5), truck drivers (43.2), operating engineers (37.2), roofers (32.8), and electricians (29.0). Falls (26.7%), electrocutions (20.4%), and motor vehicle accidents (18.9%) were found to be the leading causes of death. These findings suggest a need for continued attention to the hazards of heights and electric currents and a need for occupational safety standards for motor vehicles. This study also suggests that the hazards facing construction laborers require further investigation.

A Microprocessor Project for Non-Electrical Engineering Students.

ERIC Educational Resources Information Center

Swingler, D. N.

1981-01-01

Offers rationale for and a description of a microprocessor-based control system project for mechanical engineering students. Includes reasons for selecting a Texas Instruments TM990/189 microprocessor system. (SK)

Sexually Abused Boys.

ERIC Educational Resources Information Center

Reinhart, Michael A.

1987-01-01

Reports of male victims (N=189) of child sexual abuse were retrospectively reviewed. Comparison to an age- and race-matched group of female victims revealed similarities in patterns of disclosure and perpetrator characteristics. (Author/DB)

Criticality Safety Basics for INL FMHs and CSOs

DOE Office of Scientific and Technical Information (OSTI.GOV)

V. L. Putman

2012-04-01

Nuclear power is a valuable and efficient energy alternative in our energy-intensive society. However, material that can generate nuclear power has properties that require this material be handled with caution. If improperly handled, a criticality accident could result, which could severely harm workers. This document is a modular self-study guide about Criticality Safety Principles. This guide's purpose it to help you work safely in areas where fissionable nuclear materials may be present, avoiding the severe radiological and programmatic impacts of a criticality accident. It is designed to stress the fundamental physical concepts behind criticality controls and the importance of criticalitymore » safety when handling fissionable materials outside nuclear reactors. This study guide was developed for fissionable-material-handler and criticality-safety-officer candidates to use with related web-based course 00INL189, BEA Criticality Safety Principles, and to help prepare for the course exams. These individuals must understand basic information presented here. This guide may also be useful to other Idaho National Laboratory personnel who must know criticality safety basics to perform their assignments safely or to design critically safe equipment or operations. This guide also includes additional information that will not be included in 00INL189 tests. The additional information is in appendices and paragraphs with headings that begin with 'Did you know,' or with, 'Been there Done that'. Fissionable-material-handler and criticality-safety-officer candidates may review additional information at their own discretion. This guide is revised as needed to reflect program changes, user requests, and better information. Issued in 2006, Revision 0 established the basic text and integrated various programs from former contractors. Revision 1 incorporates operation and program changes implemented since 2006. It also incorporates suggestions, clarifications, and additional information from readers and from personnel who took course 00INL189. Revision 1 also completely reorganized the training to better emphasize physical concepts behind the criticality controls that fissionable material handlers and criticality safety officers must understand. The reorganization is based on and consistent with changes made to course 00INL189 due to a review of course exam results and to discussions with personnel who conduct area-specific training.« less

Long-term Surveillance Following Intralesional Steroid Injection for Benign Vocal Fold Lesions.

PubMed

Wang, Chi-Te; Lai, Mei-Shu; Cheng, Po-Wen

2017-06-01

The short-term outcomes of vocal fold steroid injection (VFSI) are well documented. However, few studies have reported the long-term outcomes following VFSI. To investigate the incidence rates of symptom recurrence and secondary interventions following VFSI for benign vocal fold lesions. This prospective cohort study was conducted at a tertiary referral medical center in Taipei, Taiwan. The cohort included 189 patients with vocal fold lesions who had received VFSI as the primary treatment between August 2011 and September 2013. All participants underwent VFSI. Long-term surveillance was conducted through structured telephonic interviews and by reviewing medical charts every 6 months over a 2-year period. We assessed the 10-item voice handicap index, dysphonic symptoms, and whether the patients had received any additional interventions after the initial VFSI. The 189 participants (32 men and 157 women; mean [SD] age, 39 [10] years [range, 20-74 years] included patients who had undergone VFSI for vocal fold nodules (n = 72), polyps (n = 72), or mucus-retention cysts (n = 45). Following VFSI, 141 patients (74.6%; 23 men and 118 women; mean age, 39 years [range, 20-70 years]) showed positive response (ie, clinically significant symptom resolution without the need for additional procedures) and received long-term surveillance. The median follow-up period was 19.4 months, and 2 patients were lost to follow-up postoperatively within 1 year. The cumulative failure rates (subjective symptom recurrence plus secondary treatments) at 6, 12, 18, and 24 months after VFSI were 12%, 17%, 24%, and 32%, respectively. When the initial response rate to VFSI (141 of 189, 74.6%) was considered altogether, VFSI remained effective after 2 years in 50% of the initially recruited 189 patients. The highest rate of long-term effectiveness of VFSI occurred in vocal polyps (54%), followed by nodules (49%) and cysts (43%). This study demonstrates that VFSI can be beneficial in managing benign vocal lesions, especially when first-line treatments are unsuitable. However, the long-term results of this study clarify that a substantial number of patients experience symptom recurrence or receive subsequent interventions within 2 years after VFSI; this should be considered in medical decision making.

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

PubMed

Dai, D; Tang, J; Rose, R; Hodgson, E; Bienstock, R J; Mohrenweiser, H W; Goldstein, J A

2001-12-01

CYP3A4 is the most abundant isoform of cytochrome P450 (CYP) in adult human liver. It metabolizes numerous clinically, physiologically, and toxicologically important compounds. The expression of CYP3A4 varies 40-fold in individual human livers, and metabolism of CYP3A4 substrates varies at least 10-fold in vivo. Single nucleotide polymorphisms (SNPs) in CYP3A4 were identified by direct sequencing of genomic DNA in 72 individuals from three different ethnic groups, including Caucasians, Blacks (African-Americans and African pygmies), and Asians. A total of 28 SNPs were identified, including five which produced coding changes M445T (CYP3A4*3), R162Q (CYP3A4*15), F189S (CYP3A4*17), L293P (CYP3A4*18), and P467S (CYP3A4*19). The latter four represent new alleic variants. Racial variability was observed for the frequency of individual SNPs. CYP3A R162Q was identified only in Black populations with an allelic frequency of 4%. CYP3A4 F189S and CYP3A4 M445T were identified in Caucasians with allelic frequencies 2% and 4%, respectively. L293P and P467S were only observed in Asians at allelic frequencies of 2%. The cDNAs for the F189S, L293P, M445T, and P467S mutant alleles were constructed by site-directed mutagenesis and expressed in an Escherichia coli expression system. Testosterone and the insecticide chlorpyrifos were used to assess the catalytic activities of the most common CYP3A4 allele (CYP3A4*1) and its allelic variants. CYP3A4 F189S exhibited lower turnover numbers for testosterone and chlorpyrifos, while CYP3A4 L293P had higher turnover numbers for both substrates. The turnover numbers of the CYP3A4 M445T and P467S alleles to metabolize these compounds were not significantly different from those of wild-type CYP3A4.

14 CFR 189.3 - Kinds of messages accepted or relayed.

Code of Federal Regulations, 2012 CFR

2012-01-01

... address: (1) Distress messages and distress traffic. (2) Messages concerning the safety of human life. (3) Flight safety messages concerning— (i) Air traffic control, including— (A) Messages concerning aircraft...

36 CFR 223.189 - Prohibitions against substitution.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL... export and substitution regulations of the Secretary of Agriculture at 36 CFR part 223, subpart D, in...

77 FR 3840 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

...-1353. Regulation Project Number: FI-189-84. Abstract: These regulations provide definitions, reporting... issue discount and the imputation of, and accounting for, interest on certain sales or exchanges of...

Polymorphous light eruption

MedlinePlus

... eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies . 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 189. ... agents. In: Patterson JW, ed. Weedon's Skin Pathology. 4th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2016:chap ...

77 FR 2947 - Notice of Intent To Grant Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... State University of Corvallis, Oregon, an exclusive license to the variety of blackberry described in U.S. Plant Patent Application Serial No. 12/660,189, ``Blackberry Plant Named `Onyx','' filed on...

2009 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2009-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2009 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

2005 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2005-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2005 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

2004 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2004-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2004 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

2008 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2008-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2008 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

49 CFR 173.189 - Batteries containing sodium or cells containing sodium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the heat insulation fitted in battery casings must be provided with thermal insulation sufficient to... preventing external short circuits, such as by providing complete electrical insulation of battery terminals...

78 FR 13257 - Pyraflufen-ethyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... relatively low acute toxicity from oral, dermal, and inhalation exposure. It produces moderate eye [[Page.... However, default processing factors were used for dry potatoes (6.5X), peanut butter (1.89X), dried beef...

1995 Kentucky traffic accident facts

DOT National Transportation Integrated Search

1995-01-01

KENTUCKYS TRAFFIC ACCIDENT FACTS report for 1995 is based on accident reports submitted to the Accident Unit housed : in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised statutes 189.635, : ...

2002 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2002-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2002 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised statutes 189.635, every law enforcement agency whose officers investigate :...

2003 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2003-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2003 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

2001 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2001-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2001 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

1996 Kentucky traffic accident facts

DOT National Transportation Integrated Search

1996-01-01

KENTUCKYS TRAFFIC ACCIDENT FACTS report for 1996 is based on accident reports submitted to the Accident Unit housed : in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised statutes 189.635, : ...

2007 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2007-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2007 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

1998 Kentucky traffic accident facts

DOT National Transportation Integrated Search

1998-01-01

KENTUCKYS TRAFFIC ACCIDENT FACTS report for 1998 is based on accident reports submitted to the Accident Unit housed : in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised statutes 189.635, : ...

2006 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2006-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2006 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate :...

1997 Kentucky traffic accident facts

DOT National Transportation Integrated Search

1997-01-01

KENTUCKYS TRAFFIC ACCIDENT FACTS report for 1997 is based on accident reports submitted to the Accident Unit housed : in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised statutes 189.635, : ...

Kentucky Traffic Collision Facts 2016

DOT National Transportation Integrated Search

2016-09-26

KENTUCKYS TRAFFIC COLLISION FACTS report is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate a vehicle ac...

2000 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2000-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2000 is based on collision reports submitted to the Kentucky State Police : Records Branch. As required by Kentucky Revised statutes 189.635, every law enforcement agency whose officers investigate :...

34 CFR 85.970 - Nonprocurement transaction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... transaction, regardless of type (except procurement contracts), including, but not limited to the following... of Federal funds. (Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p...

34 CFR 85.970 - Nonprocurement transaction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... transaction, regardless of type (except procurement contracts), including, but not limited to the following... of Federal funds. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p...

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2012 CFR

2012-04-01

...-methylenedioxy-benzene, C10H10O2. It is a natural constituent of the sassafras plant. Oil of sassafras is about... flavoring compounds. (b) Food containing any added safrole, oil of sassafras, isosafrole, or dihydrosafrole...

21 CFR 189.180 - Safrole.

Code of Federal Regulations, 2013 CFR

2013-04-01

...-methylenedioxy-benzene, C10H10O2. It is a natural constituent of the sassafras plant. Oil of sassafras is about... flavoring compounds. (b) Food containing any added safrole, oil of sassafras, isosafrole, or dihydrosafrole...

Extension of activation cross section data of long lived products in deuteron induced nuclear reactions on platinum up to 50 MeV

NASA Astrophysics Data System (ADS)

Ditrói, F.; Tárkányi, F.; Takács, S.; Hermanne, A.

2017-06-01

In the frame of a systematical study of light ion induced nuclear reactions on platinum, activation cross sections for deuteron induced reactions were investigated. Excitation functions were measured in the 20.8-49.2 MeV energy range for the natPt(d,xn)191,192,193,194,195,196m2,196g,198g,199Au, natPt(d,x)188,189,191,195m,197m,197gPt and natPt(d,x)189,190,192,194m2Ir reactions by using the stacked foil irradiation technique. The experimental results are compared with previous results from the literature and with the theoretical predictions in the TENDL-2014 and TENDL-2015 libraries. The applicability of the produced radio-tracers for wear measurements has been presented.

Ultraviolet mutagenesis in a plasmid vector replicated in lymphoid cells from patient with the melanoma-prone disorder dysplastic nevus syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seetharam, S.; Waters, H.L.; Seidman, M.M.

The hereditary dysplastic nevus syndrome (DNS) is an autosomal dominant disorder in which affected individuals have increased numbers of dysplastic (premalignant) nevi and a greater than 100-fold increased risk of developing cutaneous melanoma. Epstein-Barr virus-transformed lymphoblastoid cell lines from patients with hereditary DNS have been shown to be hypermutable to UV radiation. To examine the mechanism involved in this UV hypermutability, we used a shuttle vector plasmid, pZ189, which carries a 160-base pair marker gene, supF, and can replicate in human cells. pZ189 was treated with UV radiation and transfected into DNS6BE, a lymphoblastoid cell line from a patient withmore » hereditary DNS. Plasmid survival after UV was similar with the DNS6BE line and with a lymphoblastoid cell line from a normal donor. Plasmid mutation frequency was greater with the DNS line in accord with the DNS cellular hypermutability. Base sequence analysis was performed on 69 mutated plasmids recovered from the DNS line. There were significantly more plasmids with single base substitution mutations (P less than 0.01) in comparison to UV-treated plasmids passed through normal fibroblasts. pZ189 hypermutability and an increased frequency of single base substitutions was previously found with a cell line from a melanoma-prone xeroderma pigmentosum patient. These differences may be related to the increased melanoma susceptibility in both DNS and xeroderma pigmentosum.« less

Factors Contributing to the Preference of Korean Patients with Crohn’s Disease When Selecting an Anti-Tumor Necrosis Factor Agent (CHOICE Study)

PubMed Central

Kim, Eun Soo; Kim, Kyeong Ok; Jang, Byung Ik; Lee, Chang Kyun; Kim, Hyo Jong; Lee, Kang-Moon; Kim, You Sun; Eun, Chang Soo; Jung, Sung-Ae; Yang, Suk-Kyun; Lee, Jun; Kim, Tae-Oh; Jung, Yunho; Seo, Geom Seog; Yoon, Soon Man

2016-01-01

Background/Aims Two comparable anti-tumor necrosis factor (TNF) agents with different routes of administration (intravenous [iv] infliximab [IFX] vs subcutaneous [sc] adalimumab [ADA]) are available for patients with Crohn’s disease (CD) in Korea. This study aimed to identify the preferences of Korean CD patients for a specific anti-TNF agent and the factors contributing to the decision. Methods A prospective survey was performed among anti-TNF-naive CD patients in 10 tertiary referral hospitals. A 16-item questionnaire addressed patient preferences and the factors contributing to the decision in favor of a particular anti-TNF agent. A logistic regression was conducted to assess predictive factors for ADA preference. Results Overall, 189 patients (139 males; mean age, 32.47±11.71 years) completed the questionnaire. IFX and ADA were preferred by 63.5% (120/189) and 36.5% (69/189) of patients, respectively. The most influential reason for choosing IFX was ‘doctor’s presence’ (68.3%, 82/120), and ADA was “easy to use” (34.8%, 24/69). Amid various clinicodemographic data, having a >60-minute travel time to the hospital was a significant independent predictive factor for ADA preference. Conclusions A large number of anti-TNF-naive Korean patients with CD preferred anti-TNFs with an iv route of administration. The reassuring effect of a doctor’s presence might be the main contributing factor for this decision. PMID:26347512

Three-year outcome of a nonthoracotomy approach to cardioverter-defibrillator implantation in 189 consecutive patients.

PubMed

Brooks, R; Garan, H; Torchiana, D; Vlahakes, G J; Dziuban, S; Newell, J; McGovern, B A; Ruskin, J N

1994-11-15

To date, no long-term clinical data have been published in patients undergoing a nonthoracotomy approach to cardioverter-defibrillator system implantation. In the present report, 189 consecutive patients prospectively underwent a standardized approach to cardioverter-defibrillator system implantation in which the nonthoracotomy configurations were tested first. If satisfactory defibrillation thresholds were not obtained, thoracotomy was performed during the same intraoperative session. A nonthoracotomy system was successfully implanted in 149 of 189 patients (79%), with a higher success rate (90%) observed in patients who had more recent implantations. The overall rate of complications associated with these systems was low (11%). Over a mean follow-up of 12.5 +/- 9.3 months, 17 patients (9%) died. Three-year total, cardiac, and sudden death-free actuarial survival for all patients was 83 +/- 11%, 88 +/- 7%, and 94 +/- 2%, respectively. Three-year sudden death-free actuarial survival was higher in the nonthoracotomy than in the thoracotomy patients (97 +/- 2% vs 87 +/- 6%, p = 0.047), although total survival was similar (77 +/- 11% vs 83 +/- 7%, p = 0.77). These data suggest that a majority of patients (> 80%) requiring a cardioverter-defibrillator system can undergo implantation using a nonthoracotomy approach. Patients receiving nonthoracotomy systems have 3-year outcomes comparable to those implanted via thoracotomy. If these results are maintained, a nonthoracotomy approach will supplant thoracotomy-implanted systems as the preferred method because of the simpler implant procedure and lower overall cost involved.

Kentucky traffic collision facts 2015.

DOT National Transportation Integrated Search

2016-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2015 is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate a v...

Materials Data on CaAs (SG:189) by Materials Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kristin Persson

2016-02-10

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

46 CFR 196.35-5 - Actions required to be logged.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Onboard training, musters, and drills: held in accordance with subchapter W (Lifesaving Appliances and...(e) of this subchapter. (k) Weight handling gear, prior to departure. See § 189.35-13(b) of this...

2010 Kentucky traffic collision facts

DOT National Transportation Integrated Search

2010-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 2010 is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, every law enforcement agency whose officers investigate a v...

Materials Data on RbS (SG:189) by Materials Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kristin Persson

2014-07-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

46 CFR 189.01-5 - Posting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... framed under glass or other transparent material and posted in a conspicuous place where it will be most likely to be observed. On other vessels such as barges, where the framing of the certificate under glass...

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... harmless lactic-acid-producing bacteria, present in such milk or added thereto. Harmless artificial.... (d) For the purposes of this section, “skim milk” means cow's milk from which the milk fat has been...

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... harmless lactic-acid-producing bacteria, present in such milk or added thereto. Harmless artificial.... (d) For the purposes of this section, “skim milk” means cow's milk from which the milk fat has been...

21 CFR 133.189 - Skim milk cheese for manufacturing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... harmless lactic-acid-producing bacteria, present in such milk or added thereto. Harmless artificial.... (d) For the purposes of this section, “skim milk” means cow's milk from which the milk fat has been...

Credit Card Rate Freeze Act of 2009

THOMAS, 111th Congress

Sen. Dodd, Christopher J. [D-CT

2009-10-26

Senate - 10/27/2009 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 189. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

1999 Kentucky traffic accident facts

DOT National Transportation Integrated Search

1999-01-01

KENTUCKYS TRAFFIC COLLISION FACTS report for 1999 is based on accident reports submitted to the Accident Unit housed in the Kentucky State Police Information Services Branch, Records Section. As required by Kentucky Revised statutes 189.635, ev...

Application of the WFD cost proportionality principle to diffuse pollution mitigation: a case study for Scottish Lochs.

PubMed

Vinten, A J A; Martin-Ortega, J; Glenk, K; Booth, P; Balana, B B; MacLeod, M; Lago, M; Moran, D; Jones, M

2012-04-30

The Water Framework Directive (WFD) aims to deliver good ecological status (GES) for Europe's waters. It prescribes the use of economic principles, such as derogation from GES on grounds of disproportionate costs of mitigation. This paper proposes an application of the proportionality principle to mitigation of phosphorus (P) pollution of 544 Scottish lochs at national and local water body scales. P loading estimates were derived from a national diffuse pollution screening tool. For 293 of these lochs (31% of the loch area), GES already occurred. Mitigation cost-effectiveness was assessed using combined mitigation cost curves for managed grassland, rough grazing, arable land, sewage and septic tank sources. These provided sufficient mitigation (92% of national P load) for GES to be achieved on another 31% of loch area at annualised cost of £2.09 m/y. Mitigation of the residual P loading preventing other lochs achieving GES was considered by using a "mop-up" cost of £200/kg P (assumed cost effectiveness of removal of P directly from lochs), leading to a total cost of £189 m/y. Lochs were ranked by mitigation costs per loch area to give a national scale marginal mitigation cost curve. A published choice experiment valuation of WFD targets for Scottish lochs was used to estimate marginal benefits at national scale and combined with the marginal cost curve. This gave proportionate costs of £5.7 m/y leading to GES in 72% of loch area. Using national mean marginal benefits with a scheme to estimate changes in individual loch value with P loading gave proportionate costs of £25.6 m/y leading to GES in 77% of loch area (491 lochs). Copyright © 2011 Elsevier Ltd. All rights reserved.

Elevated Serum Polybrominated Diphenyl Ethers and Alteration of Thyroid Hormones in Children from Guiyu, China

PubMed Central

Xu, Xijin; Liu, Junxiao; Zeng, Xiang; Lu, Fangfang; Chen, Aimin; Huo, Xia

2014-01-01

Informal electronic waste (e-waste) recycling results in serious environmental pollution of polybrominated diphenyl ethers (PBDEs) and heavy metals. This study explored whether there is an association between PBDEs, heavy metal and key growth- and development-related hormones in children from Guiyu, an e-waste area in southern China. We quantified eight PBDE congeners using gas chromatographic mass spectrometry, lead and cadmium utilizing graphite furnace atomic absorption spectrometry, three thyroids with radioimmunoassay and two types of growth hormones by an enzyme-linked immune-sorbent assay (ELISA) in 162 children, 4 to 6 years old, from Guiyu. In blood, median total PBDE was 189.99 ng/g lipid. Lead and cadmium concentrations in blood averaged 14.53±4.85 µg dL−1 and 0.77±0.35 µg L−1, respectively. Spearman partial correlation analysis illustrated that lead was positively correlated with BDE153 and BDE183. Thyroid-stimulating hormone (TSH) was positively correlated with almost all PBDE congeners and negatively correlated with insulin-like growth factor binding protein-3 (IGFBP-3), whereas free triiodothyronine (FT3) and free thyroxine (FT4) were negatively correlated with BDE154. However, no correlation between the hormones and blood lead or cadmium levels was found in this study. Adjusted multiple linear regression analysis showed that total PBDEs was negatively associated with FT3 and positively associated with TSH. Notably, FT4 was positively correlated with FT3, house functions as a workshop, and father's work involved in e-waste recycling and negatively correlated with vitamin consumptions. TSH was negatively related with FT4, paternal residence time in Guiyu, working hours of mother, and child bean products intake. IGFBP-3 was positively correlated with IGF-1 and house close to an e-waste dump. These results suggest that elevated PBDEs and heavy metals related to e-waste in Guiyu may be important risk factors for hormone alterations in children. PMID:25415336

The journey from traffic offender to severe road trauma victim: destiny or preventive opportunity?

PubMed

Ho, Kwok M; Rao, Sudhakar; Burrell, Maxine; Weeramanthri, Tarun S

2015-01-01

Road trauma is a leading cause of death and injury in young people. Traffic offences are common, but their importance as a risk indicator for subsequent road trauma is unknown. This cohort study assessed whether severe road trauma could be predicted by a history of prior traffic offences. Clinical data of all adult road trauma patients admitted to the Western Australia (WA) State Trauma Centre between 1998 and 2013 were linked to traffic offences records at the WA Department of Transport. The primary outcomes were alcohol exposure prior to road trauma, severe trauma (defined by Injury Severity Score >15), and intensive care admission (ICU) or death, analyzed by logistic regression. Traffic offences directly leading to the road trauma admissions were excluded. Of the 10,330 patients included (median age 34 years-old, 78% male), 1955 (18.9%) had alcohol-exposure before road trauma, 2415 (23.4%) had severe trauma, 1360 (13.2%) required ICU admission, and 267 (2.6%) died. Prior traffic offences were recorded in 6269 (60.7%) patients. The number of prior traffic offences was significantly associated with alcohol-related road trauma (odds ratio [OR] per offence 1.03, 95% confidence interval [CI] 1.02-1.05), severe trauma (OR 1.13, 95%CI 1.14-1.15), and ICU admission or death (OR 1.10, 95%CI 1.08-1.11). Drink-drinking, seat-belt, and use of handheld electronic device offences were specific offences strongly associated with road trauma leading to ICU admission or death--all in a 'dose-related' fashion. For those who recovered from road trauma after an ICU admission, there was a significant reduction in subsequent traffic offences (mean difference 1.8, 95%CI 1.5 to 2.0) and demerit points (mean difference 7.0, 95%CI 6.5 to 7.6) compared to before the trauma event. Previous traffic offences were a significant risk factor for alcohol-related road trauma and severe road trauma leading to ICU admission or death.

Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Stephani; Arora, Monica; Fernandez, Cristina

Background: There is limited research examining the relationship between lead (Pb) exposure and medically diagnosed attention deficit hyperactivity disorder (ADHD) in children. The role of mercury (Hg) and cadmium (Cd) exposures in ADHD development is even less clear. Objectives: To examine the relationship between Pb, Hg, and Cd and ADHD in children living inside and outside a Lead Investigation Area (LIA) of a former lead refinery in Omaha, NE. Methods: We carried out a case-control study with 71 currently medically diagnosed ADHD cases and 58 controls from a psychiatric clinic and a pediatric clinic inside and outside of the LIA.more » The participants were matched on age group (5–8, 9–12 years), sex, race (African American or Caucasians and others), and location (inside or outside LIA). We measured whole blood Pb, total Hg, and Cd using inductively coupled plasma mass spectrometry. Results: Inside the LIA, the 27 cases had blood Pb geometric mean (GM) 1.89 µg/dL and the 41 controls had 1.51 µg/dL. Outside the LIA, the 44 cases had blood Pb GM 1.02 µg/dL while the 17 controls had 0.97 µg/dL. After adjustment for matching variables and maternal smoking, socioeconomic status, and environmental tobacco exposure, each natural log unit blood Pb had an odds ratio of 2.52 with 95% confidence interval of 1.07–5.92. Stratification by the LIA indicated similar point estimate but wider CIs. No associations were observed for Hg or Cd. Conclusions: Postnatal Pb exposure may be associated with higher risk of clinical ADHD, but not the postnatal exposure to Hg or Cd. -- Highlights: • Blood Pb levels are associated with ADHD diagnosis in children. • No association was found between blood Cd or Hg levels and ADHD. • Children living close to hazardous waste site need to reduce metal exposure.« less

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

PubMed Central

Nogales, Aitor; Martinez-Sobrido, Luis

2016-01-01

ABSTRACT Influenza virus NS1 protein is a nonstructural, multifunctional protein that counteracts host innate immune responses, modulating virus pathogenesis. NS1 protein variability in subjects infected with H3N2 influenza A viruses (IAVs) during the 2010/2011 season was analyzed, and amino acid changes in residues 86, 189, and 194 were found. The consequences of these mutations for the NS1-mediated inhibition of IFN responses and the pathogenesis of the virus were evaluated, showing that NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, most probably because these mutations decreased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF30). A recombinant A/Puerto Rico/8/34 (PR8) H1N1 virus encoding the H3N2 NS1-D189N protein was slightly attenuated, whereas the virus encoding the H3N2 NS1-V194I protein was further attenuated in mice. The higher attenuation of this virus could not be explained by differences in the ability of the two NS1 proteins to counteract host innate immune responses, indicating that another factor must be responsible. In fact, we showed that the virus encoding the H3N2 NS1-V194I protein demonstrated a temperature-sensitive (ts) phenotype, providing a most likely explanation for the stronger attenuation observed. As far as we know, this is the first description of a mutation in NS1 residue 194 conferring a ts phenotype. These studies are relevant in order to identify new residues important for NS1 functions and in human influenza virus surveillance to assess mutations affecting the pathogenicity of circulating viruses. IMPORTANCE Influenza viral infections represent a serious public health problem, with influenza virus causing a contagious respiratory disease that is most effectively prevented through vaccination. The multifunctional nonstructural protein 1 (NS1) is the main viral factor counteracting the host antiviral response. Therefore, influenza virus surveillance to identify new mutations in the NS1 protein affecting the pathogenicity of the circulating viruses is highly important. In this work, we evaluated amino acid variability in the NS1 proteins from H3N2 human seasonal viruses and the effect of the mutations on innate immune responses and virus pathogenesis. NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. Interestingly, a virus encoding the H3N2 NS1-V194I protein demonstrated a temperature-sensitive phenotype, further attenuating the virus in vivo. PMID:28003482

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.

PubMed

Nogales, Aitor; Martinez-Sobrido, Luis; Topham, David J; DeDiego, Marta L

2017-03-01

Influenza virus NS1 protein is a nonstructural, multifunctional protein that counteracts host innate immune responses, modulating virus pathogenesis. NS1 protein variability in subjects infected with H3N2 influenza A viruses (IAVs) during the 2010/2011 season was analyzed, and amino acid changes in residues 86, 189, and 194 were found. The consequences of these mutations for the NS1-mediated inhibition of IFN responses and the pathogenesis of the virus were evaluated, showing that NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, most probably because these mutations decreased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF30). A recombinant A/Puerto Rico/8/34 (PR8) H1N1 virus encoding the H3N2 NS1-D189N protein was slightly attenuated, whereas the virus encoding the H3N2 NS1-V194I protein was further attenuated in mice. The higher attenuation of this virus could not be explained by differences in the ability of the two NS1 proteins to counteract host innate immune responses, indicating that another factor must be responsible. In fact, we showed that the virus encoding the H3N2 NS1-V194I protein demonstrated a temperature-sensitive (ts) phenotype, providing a most likely explanation for the stronger attenuation observed. As far as we know, this is the first description of a mutation in NS1 residue 194 conferring a ts phenotype. These studies are relevant in order to identify new residues important for NS1 functions and in human influenza virus surveillance to assess mutations affecting the pathogenicity of circulating viruses. IMPORTANCE Influenza viral infections represent a serious public health problem, with influenza virus causing a contagious respiratory disease that is most effectively prevented through vaccination. The multifunctional nonstructural protein 1 (NS1) is the main viral factor counteracting the host antiviral response. Therefore, influenza virus surveillance to identify new mutations in the NS1 protein affecting the pathogenicity of the circulating viruses is highly important. In this work, we evaluated amino acid variability in the NS1 proteins from H3N2 human seasonal viruses and the effect of the mutations on innate immune responses and virus pathogenesis. NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. Interestingly, a virus encoding the H3N2 NS1-V194I protein demonstrated a temperature-sensitive phenotype, further attenuating the virus in vivo . Copyright © 2017 American Society for Microbiology.

Self-sustained reduction of multiple metals in a microbial fuel cell-microbial electrolysis cell hybrid system.

PubMed

Li, Yan; Wu, Yining; Liu, Bingchuan; Luan, Hongwei; Vadas, Timothy; Guo, Wanqian; Ding, Jie; Li, Baikun

2015-09-01

A self-sustained hybrid bioelectrochemical system consisting of microbial fuel cell (MFC) and microbial electrolysis cell (MEC) was developed to reduce multiple metals simultaneously by utilizing different reaction potentials. Three heavy metals representing spontaneous reaction (chromium, Cr) and unspontaneous reaction (lead, Pb and nickel, Ni) were selected in this batch-mode study. The maximum power density of the MFC achieved 189.4 mW m(-2), and the energy recovery relative to the energy storage circuit (ESC) was ∼ 450%. At the initial concentration of 100 mg L(-1), the average reduction rate of Cr(VI) was 30.0 mg L(-1) d(-1), Pb(II) 32.7 mg L(-1) d(-1), and Ni(II) 8.9 mg L(-1) d(-1). An electrochemical model was developed to predict the change of metal concentration over time. The power output of the MFC was sufficient to meet the requirement of the ESC and MEC, and the "self-sustained metal reduction" was achieved in this hybrid system. Published by Elsevier Ltd.

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.

PubMed

Wang, Zhi-Hao; Gong, Ke; Liu, Xia; Zhang, Zhentao; Sun, Xiaoou; Wei, Zheng Zachory; Yu, Shan Ping; Manfredsson, Fredric P; Sandoval, Ivette M; Johnson, Peter F; Jia, Jianping; Wang, Jian-Zhi; Ye, Keqiang

2018-05-03

Delta-secretase cleaves both APP and Tau to mediate the formation of amyloid plaques and neurofibrillary tangle in Alzheimer's disease (AD). However, how aging contributes to an increase in delta-secretase expression and AD pathologies remains unclear. Here we show that a CCAAT-enhancer-binding protein (C/EBPβ), an inflammation-regulated transcription factor, acts as a key age-dependent effector elevating both delta-secretase (AEP) and inflammatory cytokines expression in mediating pathogenesis in AD mouse models. We find that C/EBPβ regulates delta-secretase transcription and protein levels in an age-dependent manner. Overexpression of C/EBPβ in young 3xTg mice increases delta-secretase and accelerates the pathological features including cognitive dysfunctions, which is abolished by inactive AEP C189S. Conversely, depletion of C/EBPβ from old 3xTg or 5XFAD mice diminishes delta-secretase and reduces AD pathologies, leading to amelioration of cognitive impairment in these AD mouse models. Thus, our findings support that C/EBPβ plays a pivotal role in AD pathogenesis via increasing delta-secretase expression.

75 FR 27551 - Duke Energy Carolinas, LLC; Notice of Availability of Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

... floating, cluster docks accommodating a total of 30 watercraft, one concrete boat ramp, and 189 linear feet... of the project boundary. The EA contains Commission staff's analysis of the probable environmental...

Materials Data on CeInIr (SG:189) by Materials Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kristin Persson

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

11. Building Layout, 185189 D, U.S. Atomic Energy Commission, Richland ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Building Layout, 185-189 D, U.S. Atomic Energy Commission, Richland Operations Office, Dwg. No. H-1-14844, 1957. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

Materials Data on Pu2Co (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2014-11-02

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Ni2P (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2014-11-02

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Na2O2 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2014-11-02

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on ZrMoP (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2014-11-02

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on K(WO3)9 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2016-04-22

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

An original resolution authorizing expenditures by the Committee on Rules and Administration.

THOMAS, 113th Congress

Sen. Schumer, Charles E. [D-NY

2013-09-17

Senate - 09/17/2013 Placed on Senate Legislative Calendar under General Orders. Calendar No. 189. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Michigan's Fourth Forest Inventory: Area.

Treesearch

John S. Jr. Spencer

1983-01-01

The fourth inventory of Michigan's forest resources found 17.5 million acres of commercial forest, down 7% from the 18.9 million found in 1966. This bulletin analyzes findings from the inventory and presents detailed tables of forest area.

Materials Data on TbAlNi (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on TbAgGe (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Measurement of e+e-→K K ¯J /ψ cross sections at center-of-mass energies from 4.189 to 4.600 GeV

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, P. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, S.; Gu, Y. T.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y. P.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Khan, T.; Kiese, P.; Kliemt, R.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuhlmann, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Lavezzi, L.; Leiber, S.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, J. Q.; Li, Jin; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Morello, G.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, J. J.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, Meng; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, X.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Y. J.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. H.; Yang, Y. X.; Yang, Yifan; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhou, Y. X.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2018-04-01

We investigate the process e+e-→K K ¯J /ψ at center-of-mass energies from 4.189 to 4.600 GeV using 4.7 fb-1 of data collected by the BESIII detector at the BEPCII collider. The Born cross sections for the reactions e+e-→K+K-J /ψ and KS0KS0J /ψ are measured as a function of center-of-mass energy. The energy dependence of the cross section for e+e-→K+K-J /ψ is shown to differ from that for π+π-J /ψ in the region around the Y (4260 ). In addition, there is evidence for a structure around 4.5 GeV in the e+e-→K+K-J /ψ cross section that is not present in π+π-J /ψ .

Measurement of e + e − → K K ¯ J / ψ cross sections at center-of-mass energies from 4.189 to 4.600 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

2018-04-01

We investigate the process e+e ! K K J= at center-of-mass energies from 4.189 to 4.600 GeV using 4.7 fb1 of data collected by the BESIII detector at the BEPCII collider. The Born cross sections for the reactions e+e ! K+KJ= and K0S K0S J= are measured as a function of center- of-mass energy. The energy dependence of the cross section for e+e ! K+KJ= is shown to di er from that for +J= in the region around the Y (4260). In addition, there is evidence for a structure around 4.5 GeV in the e+e ! K+KJ= cross section thatmore » is not present in +J= .« less

Travel Times for Screening Mammography: Impact of Geographic Expansion by a Large Academic Health System.

PubMed

Rosenkrantz, Andrew B; Liang, Yu; Duszak, Richard; Recht, Michael P

2017-09-01

This study aims to assess the impact of off-campus facility expansion by a large academic health system on patient travel times for screening mammography. Screening mammograms performed from 2013 to 2015 and associated patient demographics were identified using the NYU Langone Medical Center Enterprise Data Warehouse. During this time, the system's number of mammography facilities increased from 6 to 19, reflecting expansion beyond Manhattan throughout the New York metropolitan region. Geocoding software was used to estimate driving times from patients' homes to imaging facilities. For 147,566 screening mammograms, the mean estimated patient travel time was 19.9 ± 15.2 minutes. With facility expansion, travel times declined significantly (P < 0.001) from 26.8 ± 18.9 to 18.5 ± 13.3 minutes (non-Manhattan residents: from 31.4 ± 20.3 to 18.7 ± 13.6). This decline occurred consistently across subgroups of patient age, race, ethnicity, payer status, and rurality, leading to decreased variation in travel times between such subgroups. However, travel times to pre-expansion facilities remained stable (initial: 26.8 ± 18.9 minutes, final: 26.7 ± 18.6 minutes). Among women undergoing mammography before and after expansion, travel times were shorter for the postexpansion mammogram in only 6.3%, but this rate varied significantly (all P < 0.05) by certain demographic factors (higher in younger and non-Hispanic patients) and was as high as 18.2%-18.9% of patients residing in regions with the most active expansion. Health system mammography facility geographic expansion can improve average patient travel burden and reduce travel time variation among sociodemographic populations. Nonetheless, existing patients strongly tend to return to established facilities despite potentially shorter travel time locations, suggesting strong site loyalty. Variation in travel times likely relates to various factors other than facility proximity. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure.

PubMed

Jirak, Peter; Fejzic, Dzeneta; Paar, Vera; Wernly, Bernhard; Pistulli, Rudin; Rohm, Ilonka; Jung, Christian; Hoppe, Uta C; Schulze, P Christian; Lichtenauer, Michael; Yilmaz, Atilla; Kretzschmar, Daniel

2017-12-14

Chronic heart failure (CHF) represents a major cause of hospitalization and death. Recent evidence shows that novel biomarkers such as soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR) and heart-type fatty acid binding protein (H-FABP) are correlated with inflammatory and ischemic responses in CHF patients. In this study we examined the effects of Ivabradine that inhibited the hyperpolarization-activated cyclic nucleotide-gated channel (HCN channel, also called funny current I f ), thereby leading to selective heart rate reduction and improved myocardial oxygen supply on the cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in 50 CHF patients at the University Hospital of Jena. Patients were divided into three groups based on the etiology of CHF: dilated cardiomyopathy (DCM, n=20), ischemic cardiomyopathy (ICM, n=20) and hypertensive cardiomyopathy (HCM, n=10). The patients were administered Ivabradine (5 mg, bid for 3 months, and 7.5 mg bid for further 3 months). Analyses of cardiovascular biomarkers were performed at baseline as well as at 3- and 6-month follow-ups. At 6-month follow-up, GDF-15 levels were significantly reduced compared to baseline levels (P=0.0215), indicating a reduction in the progress of cardiac remodeling. H-FABP concentration was significantly lower in DCM patients compared to ICM (1.89 vs 3.24 μg/mL) and HCM patients (1.89 vs 3.80 μg/mL), and decreased over the 6-month follow-up (P=0.0151). suPAR median levels remained elevated, implying major ongoing inflammatory processes. As shown by significant decreases in GDF-15 and H-FABP levels, a reduction in ventricular remodeling and sub-clinical ischemia could be assumed. However, markers of hemodynamic stress (sST2) and inflammation (suPAR) showed no change or progression after 6 months of Ivabradine treatment in CHF patients. Further studies are necessary to validate the clinical applicability of these novel cardiovascular biomarkers.

Outcome Analyses of 15,189 Screenings Via Colonoscopy.

PubMed

Liu, Lan; Gao, Hongwei; Yu, Weihua; Zhang, Shanyan; Guo, Jianqiang; Zhu, Kongxi

2017-10-01

This study investigated the detection rates of common colorectal diseases during colonoscopy procedures to provide reference for clinical diagnoses in China. A total of 15,189 participants, who underwent total colonoscopy, were studied. We analyzed the detection rates of common colorectal diseases in different sex, age, and decade groups. The most common indication for colonoscopy is abdominal pain followed by change in bowel habits. Among the 15,189 participants, 5658 cases (37.25%) were normal. The most common positive finding was colorectal polyp (27.32%) followed by nonspecific colitis (12.06%), colorectal cancer (CRC) (7.71%), and ulcerative colitis (4.64%). The frequencies of polyp (31.56% vs. 21.99%; P=0.000) and CRC (8.28% vs. 7.00%; P=0.004) were higher in males than in females. By contrast, ischemic colitis (0.08% vs. 0.31%; P=0.001) and melanosis coli (1.15% vs. 1.87%; P=0.000) were more seen in females than in males. In addition, the detection rates for CRC (2.42% vs. 7.18% vs. 16.67%; P=0.000), colorectal polyp (17.65% vs. 32.27% vs. 34.73%; P=0.000), ischemic colitis (0.09% vs. 0.19% vs. 0.32%; P=0.033), and melanosis coli (0.71% vs. 1.09% vs. 3.21%; P=0.000) increased with age. The frequent positive findings were colorectal polyp, nonspecific colitis, and CRC. Patients showing alarming symptoms definitely require colonoscopy. The detection rates for colorectal polyp and melanosis coli were significantly higher in the later decade, so we should focus on these deseases.

Cause of death and predictors of mortality in a community-based cohort of people with epilepsy.

PubMed

Keezer, Mark R; Bell, Gail S; Neligan, Aidan; Novy, Jan; Sander, Josemir W

2016-02-23

The risk of premature mortality is increased in people with epilepsy. The reasons for this and how it may relate to epilepsy etiology remain unclear. The National General Practice Study of Epilepsy is a prospective, community-based cohort that includes 558 people with recurrent unprovoked seizures of whom 34% died during almost 25 years of follow-up. We assessed the underlying and immediate causes of death and their relationship to epilepsy etiology. Psychiatric and somatic comorbidities of epilepsy as predictors of mortality were scrutinized using adjusted Cox proportional hazards models. The 3 most common underlying causes of death were noncerebral neoplasm, cardiovascular, and cerebrovascular disease, accounting for 59% (111/189) of deaths, while epilepsy-related causes (e.g., sudden unexplained death in epilepsy) accounted for 3% (6/189) of deaths. In 23% (43/189) of individuals, the underlying cause of death was directly related to the epilepsy etiology; this was significantly more likely if death occurred within 2 years of the index seizure (percent ratio 4.28 [95% confidence interval 2.63-6.97]). Specific comorbidities independently associated with increased risk of mortality were neoplasms (primary cerebral and noncerebral neoplasm), certain neurologic diseases, and substance abuse. Comorbid diseases are important causes of death, as well as predictors of premature mortality in epilepsy. There is an especially strong relationship between cause of death and epilepsy etiology in the first 2 years after the index seizure. Addressing these issues may help stem the tide of premature mortality in epilepsy. © 2016 American Academy of Neurology.

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bredberg, A.; Kraemer, K.H.; Seidman, M.M.

1986-11-01

A shuttle vector plasmid, pZ189, carrying a bacterial suppressor tRNA marker gene, was treated with ultraviolet radiation and propagated in cultured skin cells from a patient with the skin-cancer-prone, DNA repair-deficient disease xeroderma pigmentosum and in repair-proficient cells. After replication in the human cells, progeny plasmids were purified. Plasmid survival and mutations inactivating the marker gene were scored by transforming an indicator strain of Escherichia coli carrying a suppressible amber mutation in the beta-galactosidase gene. Plasmid survival in the xeroderma pigmentosum cells was less than that of pZ189 harvested from repair-proficient human cells. The point-mutation frequency in the 150-base-pair tRNAmore » marker gene increased up to 100-fold with ultraviolet dose. Sequence analysis of 150 mutant plasmids revealed that mutations were infrequent at potential thymine-thymine dimer sites. Ninety-three percent of the mutant plasmids from the xeroderma pigmentosum cells showed G X C----A X T transitions, compared to 73% in the normal cells (P less than 0.002). There were significantly fewer transversions (P less than 0.002) (especially G X C----T X A) and multiple base substitutions (P less than 0.00001) than when pZ189 was passaged in repair-proficient cells. The subset of mutational changes that are common to ultraviolet-treated plasmids propagated in both repair-proficient and xeroderma pigmentosum skin cells may be associated with the development of ultraviolet-induced skin cancer in humans.« less

29 CFR 18.9 - Consent order or settlement; settlement judge procedure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... shall not be appointed when— (i) A party objects to referral of the matter to a settlement judge; (ii... as the Black Lung Benefits Act. (3) Selection of settlement judge. (i) The selection of a settlement...

29 CFR 18.9 - Consent order or settlement; settlement judge procedure.

Code of Federal Regulations, 2014 CFR

2014-07-01

... shall not be appointed when— (i) A party objects to referral of the matter to a settlement judge; (ii... as the Black Lung Benefits Act. (3) Selection of settlement judge. (i) The selection of a settlement...

29 CFR 18.9 - Consent order or settlement; settlement judge procedure.

Code of Federal Regulations, 2013 CFR

2013-07-01

... shall not be appointed when— (i) A party objects to referral of the matter to a settlement judge; (ii... as the Black Lung Benefits Act. (3) Selection of settlement judge. (i) The selection of a settlement...

29 CFR 18.9 - Consent order or settlement; settlement judge procedure.

Code of Federal Regulations, 2012 CFR

2012-07-01

... shall not be appointed when— (i) A party objects to referral of the matter to a settlement judge; (ii... as the Black Lung Benefits Act. (3) Selection of settlement judge. (i) The selection of a settlement...

29 CFR 18.9 - Consent order or settlement; settlement judge procedure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... shall not be appointed when— (i) A party objects to referral of the matter to a settlement judge; (ii... as the Black Lung Benefits Act. (3) Selection of settlement judge. (i) The selection of a settlement...

View of the mission control center during STS 51-I

NASA Image and Video Library

1985-08-27

51I-S-189 (27 Aug 1985) --- View of the mission control center (MCC) during STS 51-I as flight controllers watch monitors at consoles to follow the extravehicular activity of two of the Discovery's astronauts.

Materials Data on Nd2(Zn2Ge)3 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Ce2(Zn2Ge)3 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Sm2(Zn2Ge)3 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Pr2(Zn2Ge)3 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2015-02-09

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Materials Data on Ca5P12Rh19 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2014-11-02

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

Mixing and Transport.

ERIC Educational Resources Information Center

Ditmars, John D.

1978-01-01

Presents a literature review of longitudinal dispersion, mixing and transport in streams, rivers, lakes, reservoirs, estuaries, and oceans. This review covers also: (1) fluid-solid mixtures and (2) oil spill behavior. A list of 189 references published in 1976 and 1977 is presented. (HM)

Ocean Drilling Program: Public Information: Life Onboard JOIDES Resolution

Science.gov Websites

2002) Leg 200 (Dec 2001-Jan 2002) Legs 190-199 Legs 176-189 Life Onboard JOIDES Resolution The reports hope that they provide a better understanding of the research activities and lifestyle of the

Deer Creek Dam, Hydroelectric Powerplant, 868 feet/291 degrees from intersection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Deer Creek Dam, Hydroelectric Powerplant, 868 feet/291 degrees from intersection of dam complex access road with U.S. Highway 189, 1,340 feet/352 degrees from the dam spillway overpass, Charleston, Wasatch County, UT

Electro-mechanical characterization of structural supercapacitors

NASA Astrophysics Data System (ADS)

Gallagher, T.; LaMaster, D.; Ciocanel, C.; Browder, C.

2012-04-01

The paper presents electrical and mechanical properties of structural supercapacitors and discusses limitations associated with the approach taken for the electrical properties evaluation. The structural supercapacitors characterized in this work had the electrodes made of carbon fiber weave, separator made of several cellulose based products, and the solid electrolyte made as PEGDGE based polymer blend. The reported electrical properties include capacitance and leakage resistance; the former was measured using cyclic voltammetry. Mechanical properties have been evaluated thorough tensile and three point bending tests performed on structural supercapacitor coupons. The results indicate that the separator material plays an important role on the electrical as well as mechanical properties of the structural capacitor, and that Celgard 3501 used as separator leads to most benefits for both mechanical and electrical properties. Specific capacitance and leakage resistance as high as 1.4kF/m3 and 380kΩ, respectively, were achieved. Two types of solid polymer electrolytes were used in fabrication, with one leading to higher and more consistent leakage resistance values at the expense of a slight decrease in specific capacitance when compared to the other SPE formulation. The ultimate tensile strength and modulus of elasticity of the developed power storage composite were evaluated at 466MPa and 18.9MPa, respectively. These values are 58% and 69% of the tensile strength and modulus of elasticity values measured for a single layer composite material made with the same type of carbon fiber and with a West System 105 epoxy instead of solid polymer electrolyte.

Pulsed direct flame deposition and thermal annealing of transparent amorphous indium zinc oxide films as active layers in field effect transistors.

PubMed

Kilian, Daniel; Polster, Sebastian; Vogeler, Isabell; Jank, Michael P M; Frey, Lothar; Peukert, Wolfgang

2014-08-13

Indium-zinc oxide (IZO) films were deposited via flame spray pyrolysis (FSP) by pulsewise shooting a Si/SiO2 substrate directly into the combustion area of the flame. Based on UV-vis measurements of thin-films deposited on glass substrates, the optimal deposition parameters with respect to low haze values and film thicknesses of around 100 nm were determined. Thermal annealing of the deposited films at temperatures between 300 and 700 °C was carried out and staggered bottom gate thin-film transistors (TFT) were fabricated. The thin films were investigated by scanning electron microscopy, atomic force microscopy, X-ray diffraction, Fourier transformed infrared spectroscopy, and room-temperature photoluminescence measurements. The outcome of these investigations lead to two major requirements in order to implement a working TFT: (i) organic residues from the deposition process need to be removed and (ii) the net free charge carrier concentration has to be minimized by controlling the trap states in the semiconductor. The optimal annealing temperature was 300 °C as both requirements are fulfilled best in this case. This leads to field effect transistors with a low hysteresis, a saturation mobility of μSat = 0.1 cm(2)/(V s), a threshold voltage of Vth = -18.9 V, and an Ion/Ioff ratio on the order of 10(7). Depending on thermal treatment, the defect density changes significantly strongly influencing the transfer characteristics of the device.

Your P.A.D. Checklist

MedlinePlus

... TOTAL CHOLESTEROL Desirable : less than 200 mg/dL Borderline High: 200 – 239 mg/dL High : 240 mg/ ... mg/dL Near Optimal : 100 –129 mg/dL Borderline High : 130 –159 mg/dL High : 160 –189 ...

13. Architectural First Floor Plan Buildings 185189 D, U.S. Atomic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Architectural First Floor Plan Buildings 185-189 D, U.S. Atomic Energy Commission, General Electric Company, Dwg. NO. H-1-11825, 1959. - D-Reactor Complex, Deaeration Plant-Refrigeration Buildings, Area 100-D, Richland, Benton County, WA

7 CFR 51.1176 - U.S. Grade AA Juice (Double A).

Code of Federal Regulations, 2013 CFR

2013-01-01

... less than 5 gallons (18.9 liters) of juice per standard packed box of 13/5 bushels. (b) The average... less than one-half of 1 percent anhydrous citric acid, or more than the permissible maximum acid...

5. Photocopy of a drawing (original in the Collection of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy of a drawing (original in the Collection of the PL&C, Shelf 118, Drawing 189) PLAN OF DAM FROM MERRIMACK CANAL NEAR THE MERRIMACK MILLS, MAY, 10, 1836 - Merrimack Canal, Merrimack Dam, Lowell, Middlesex County, MA

21 CFR 189.175 - P-4000.

Code of Federal Regulations, 2011 CFR

2011-04-01

...-propoxyaniline, C9H12N2O3. It is a synthetic chemical having a sweet taste about 4000 times that of sucrose, is... for use as an artificial sweetener. (b) Food containing any added or detectable level of P-4000 is...

21 CFR 189.145 - Dulcin.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., C9H12N2O2. It is a synthetic chemical having a sweet taste about 250 times that of sucrose, is not found in... artificial sweetener. (b) Food containing any added or detectable level of dulcin is deemed to be adulterated...

21 CFR 189.130 - Coumarin.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., C9H6O2. It is found in tonka beans and extract of tonka beans, among other natural sources, and is also... constituent of tonka beans or tonka extract is deemed to be adulterated under the act, based upon an order...

76 FR 189 - Final Regulatory Guide: Issuance, Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

.../reading-rm/doc-collections/ . In addition, regulatory guides are available for inspection at the NRC's... NUCLEAR REGULATORY COMMISSION [NRC-2010-0265] Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 3...

Materials Data on K14(Tl7Cd3)3 (SG:189) by Materials Project

DOE Data Explorer

Kristin Persson

2016-04-23

Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

46 CFR 189.01-10 - Period of validity for a Certificate of Inspection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... inspection at any time during the period of validity of the current certificate. (b) Certificates of... be issued for a specific period of time to cover a described situation or for one voyage only but not...

Data Quality -- A Key to Successfully Implementing ECSS

DTIC Science & Technology

2009-03-01

Inventory inaccuracy and supply chain performance: A simulation study of a retail supply chain. International Journal of Production Economics , 95...Planning (ERP) System Implementations Based on Critical Success Factors (CSFs). International Journal of Production Economics , 98(2), 189- 203. Tersine

The national trend of blood lead levels among Chinese children aged 0-18 years old, 1990-2012.

PubMed

Li, Min-ming; Cao, Jia; Xu, Jian; Cai, Shi-zhong; Shen, Xiao-ming; Yan, Chong-huai

2014-10-01

We analyzed the epidemiological data during 1990-2012 that investigated the blood lead level (BLL) in the population aged 0-18 years old in China mainland and provided evidence of the benefits of implementing policies to prevent lead pollution based on the dynamic changes of BLL. Data were collected through databases including China Knowledge Resource Integrated Database (CNKI), CBM disc, Wanfang Data, Pubmed and Medline. The inclusion criteria were: 1. Epidemiological study in healthy population not included studies limited to specific patient; 2. Study subject was not the specific lead exposure population; 3. Sample size should be no less than 100 (for neonatal, no less than 50); 4. BLL detection was under strict quality control; and 5. Results should be presented as BLL (arithmetic mean level or geometric mean level). 62 articles were included in this study. All the surveys in these articles contained 189,352 subjects in 19 provinces, autonomous regions and municipalities. Linear regression analysis showed a significant decrease between 1990 and 2012 with an estimated regression coefficient of 3.05/year (SE=0.01, p<0.001). BLL gradually declined since early 21st century. Median levels of BLL among the three economic zones were 51.4 μg/L in the eastern zone, 52.72 μg/L in the central zone and 46.2 μg/L in the western zone respectively. Median BLLs in male and female population aged 0-18 years old of China were 48.8 μg/L and 46.1μg/L. Median levels of BLL among the different age ranges were 74.9 μg/L in newborn, 46.4 μg/L in 0 to 3 years old, 57.6 μg/L in 3 to 7 years old and 55.6 μg/L in above 7 years old respectively. In conclusion, the BLL in the Chinese population of 0-18 years old has gradually dropped in the past 10 years. The decline in temporal trend still remains under potential impacts of several factors such as economical level, gender and age difference. Although, China has made significant achievements in the control prevention of lead pollution, concerted efforts are still warranted to reduce children lead poisoning. Copyright © 2014 Elsevier Ltd. All rights reserved.